locus-tag	class	description
RGI145_RS00010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RGI145_RS00015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGI145_RS00020	COG0037	tRNA processing
RGI145_RS00020	COG0590	tRNA wobble adenosine to inosine editing
RGI145_RS00040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RGI145_RS00050	COG2326	polyphosphate kinase activity
RGI145_RS00060	COG3585	molybdate ion transport
RGI145_RS00080	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
RGI145_RS00085	COG3781	membrane
RGI145_RS00090	COG1120	ATPase activity
RGI145_RS00105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RGI145_RS00135	COG0438	transferase activity, transferring glycosyl groups
RGI145_RS00155	COG0438	transferase activity, transferring glycosyl groups
RGI145_RS00165	COG0438	transferase activity, transferring glycosyl groups
RGI145_RS00170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RGI145_RS00185	COG0489	protein tyrosine kinase activity
RGI145_RS00185	COG3206	protein involved in exopolysaccharide biosynthesis
RGI145_RS00190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS00195	COG1970	mechanosensitive ion channel activity
RGI145_RS00200	COG1960	acyl-CoA dehydrogenase activity
RGI145_RS00210	COG2086	electron transfer activity
RGI145_RS00215	COG1960	acyl-CoA dehydrogenase activity
RGI145_RS00220	COG1960	acyl-CoA dehydrogenase activity
RGI145_RS00225	COG0183	Belongs to the thiolase family
RGI145_RS00230	COG0318	PFAM AMP-dependent synthetase and ligase
RGI145_RS00235	COG1024	Enoyl-CoA hydratase
RGI145_RS00235	COG1250	3-hydroxyacyl-CoA dehydrogenase
RGI145_RS00270	COG1024	Enoyl-CoA hydratase
RGI145_RS00285	COG1760	l-serine dehydratase
RGI145_RS00290	COG0583	DNA-binding transcription factor activity
RGI145_RS00300	COG3842	ATPase activity
RGI145_RS00305	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGI145_RS00310	COG1177	transmembrane transport
RGI145_RS00335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS00350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RGI145_RS00355	COG0135	phosphoribosylanthranilate isomerase activity
RGI145_RS00360	COG0284	orotidine-5'-phosphate decarboxylase activity
RGI145_RS00370	COG0776	regulation of translation
RGI145_RS00375	COG0616	signal peptide processing
RGI145_RS00380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RGI145_RS00395	COG2271	Major facilitator Superfamily
RGI145_RS00405	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RGI145_RS00420	COG2261	transglycosylase associated protein
RGI145_RS00435	COG1522	sequence-specific DNA binding
RGI145_RS00440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RGI145_RS00445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RGI145_RS00455	COG1522	sequence-specific DNA binding
RGI145_RS00465	COG0656	L-ascorbic acid biosynthetic process
RGI145_RS00500	COG0588	phosphoglycerate mutase activity
RGI145_RS00510	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RGI145_RS00515	COG2050	protein possibly involved in aromatic compounds catabolism
RGI145_RS00520	COG3327	negative regulation of DNA-templated transcription, initiation
RGI145_RS00525	COG3396	Phenylacetate-CoA oxygenase
RGI145_RS00530	COG3460	Phenylacetate-CoA oxygenase
RGI145_RS00535	COG3396	Phenylacetate-CoA oxygenase
RGI145_RS00540	COG2151	metal-sulfur cluster biosynthetic enzyme
RGI145_RS00545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RGI145_RS00560	COG1024	Enoyl-CoA hydratase
RGI145_RS00565	COG2030	dehydratase
RGI145_RS00565	COG1012	belongs to the aldehyde dehydrogenase family
RGI145_RS00580	COG1802	Transcriptional regulator
RGI145_RS00585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RGI145_RS00605	COG2084	Dehydrogenase
RGI145_RS00630	COG2205	protein histidine kinase activity
RGI145_RS00635	COG0745	RESPONSE REGULATOR receiver
RGI145_RS00655	COG0583	DNA-binding transcription factor activity
RGI145_RS00670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RGI145_RS00675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RGI145_RS00680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RGI145_RS00695	COG2226	methyltransferase
RGI145_RS00710	COG1741	Belongs to the pirin family
RGI145_RS00715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RGI145_RS00735	COG2072	flavoprotein involved in K transport
RGI145_RS00745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS00755	COG0747	negative chemotaxis
RGI145_RS00770	COG0583	DNA-binding transcription factor activity
RGI145_RS00810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RGI145_RS00840	COG3246	L-lysine catabolic process to acetate
RGI145_RS00845	COG1250	3-hydroxyacyl-CoA dehydrogenase
RGI145_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS00875	COG0154	amidase activity
RGI145_RS00885	COG3038	cytochrome b561
RGI145_RS00905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RGI145_RS00920	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGI145_RS00930	COG3842	ATPase activity
RGI145_RS00945	COG1228	amidohydrolase
RGI145_RS00950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RGI145_RS00955	COG1960	acyl-CoA dehydrogenase activity
RGI145_RS00960	COG1024	Enoyl-CoA hydratase
RGI145_RS00960	COG1250	3-hydroxyacyl-CoA dehydrogenase
RGI145_RS00965	COG0183	Belongs to the thiolase family
RGI145_RS00975	COG0318	PFAM AMP-dependent synthetase and ligase
RGI145_RS00995	COG1981	membrane
RGI145_RS01005	COG1515	deoxyribonuclease V activity
RGI145_RS01010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RGI145_RS01020	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RGI145_RS01045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGI145_RS01050	COG0747	negative chemotaxis
RGI145_RS01065	COG0583	DNA-binding transcription factor activity
RGI145_RS01090	COG4774	siderophore transport
RGI145_RS01100	COG4774	siderophore transport
RGI145_RS01110	COG1802	Transcriptional regulator
RGI145_RS01115	COG0246	Mannitol dehydrogenase
RGI145_RS01125	COG0765	amino acid transport
RGI145_RS01135	COG1063	alcohol dehydrogenase
RGI145_RS01155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RGI145_RS01160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RGI145_RS01175	COG1169	isochorismate synthase
RGI145_RS01180	COG1021	2,3-dihydroxybenzoate-AMP ligase
RGI145_RS01185	COG1535	isochorismatase
RGI145_RS01185	COG3433	isochorismatase activity
RGI145_RS01190	COG3433	isochorismatase activity
RGI145_RS01190	COG1535	isochorismatase
RGI145_RS01195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RGI145_RS01195	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RGI145_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS01205	COG2819	hydrolase of the alpha beta superfamily
RGI145_RS01215	COG1414	Transcriptional regulator
RGI145_RS01225	COG2084	Dehydrogenase
RGI145_RS01230	COG3395	kinase activity
RGI145_RS01235	COG3622	Belongs to the hyi family
RGI145_RS01240	COG1349	DNA-binding transcription factor activity
RGI145_RS01245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGI145_RS01250	COG0235	Class ii aldolase
RGI145_RS01255	COG2271	Major facilitator Superfamily
RGI145_RS01275	COG0745	RESPONSE REGULATOR receiver
RGI145_RS01295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RGI145_RS01300	COG0287	Prephenate dehydrogenase
RGI145_RS01310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RGI145_RS01310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RGI145_RS01315	COG5002	protein histidine kinase activity
RGI145_RS01315	COG2205	protein histidine kinase activity
RGI145_RS01315	COG0784	Response regulator, receiver
RGI145_RS01320	COG1024	Enoyl-CoA hydratase
RGI145_RS01330	COG4310	Domain of unknown function (DUF2172)
RGI145_RS01340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RGI145_RS01355	COG0004	ammonium transporteR
RGI145_RS01360	COG0347	Belongs to the P(II) protein family
RGI145_RS01365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RGI145_RS01370	COG2271	Major facilitator Superfamily
RGI145_RS01380	COG1414	Transcriptional regulator
RGI145_RS01390	COG0747	negative chemotaxis
RGI145_RS01395	COG0601	transmembrane transport
RGI145_RS01400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS01405	COG0444	Belongs to the ABC transporter superfamily
RGI145_RS01420	COG1473	amidohydrolase
RGI145_RS01450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RGI145_RS01460	COG4172	Belongs to the ABC transporter superfamily
RGI145_RS01465	COG4239	(ABC) transporter, permease
RGI145_RS01470	COG4174	ABC transporter (Permease)
RGI145_RS01475	COG4166	transmembrane transport
RGI145_RS01490	COG3474	cytochrome
RGI145_RS01495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RGI145_RS01500	COG0077	Prephenate dehydratase
RGI145_RS01540	COG3158	transport of potassium into the cell
RGI145_RS01545	COG1126	abc transporter atp-binding protein
RGI145_RS01550	COG0765	amino acid transport
RGI145_RS01555	COG4597	amino acid ABC transporter
RGI145_RS01560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS01565	COG2423	ornithine cyclodeaminase activity
RGI145_RS01575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RGI145_RS01590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RGI145_RS01605	COG0789	Transcriptional regulator
RGI145_RS01610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RGI145_RS01615	COG0386	Belongs to the glutathione peroxidase family
RGI145_RS01660	COG0137	argininosuccinate synthase activity
RGI145_RS01675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RGI145_RS01680	COG1872	DUF167
RGI145_RS01695	COG0477	Major facilitator Superfamily
RGI145_RS01700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RGI145_RS01705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RGI145_RS01710	COG1845	cytochrome c oxidase, subunit III
RGI145_RS01715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RGI145_RS01725	COG2205	protein histidine kinase activity
RGI145_RS01730	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RGI145_RS01740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RGI145_RS01745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RGI145_RS01765	COG0583	DNA-binding transcription factor activity
RGI145_RS01770	COG0667	Aldo Keto reductase
RGI145_RS01785	COG0237	dephospho-CoA kinase activity
RGI145_RS01790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RGI145_RS01795	COG0189	ligase activity
RGI145_RS01800	COG4533	DNA binding
RGI145_RS01805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RGI145_RS01835	COG0156	8-amino-7-oxononanoate synthase activity
RGI145_RS01900	COG1473	amidohydrolase
RGI145_RS01905	COG2363	Small membrane protein
RGI145_RS01930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RGI145_RS01950	COG2860	membrane
RGI145_RS01960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RGI145_RS01975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RGI145_RS01990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS02010	COG4608	Belongs to the ABC transporter superfamily
RGI145_RS02020	COG0625	glutathione transferase activity
RGI145_RS02045	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RGI145_RS02050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RGI145_RS02055	COG0747	negative chemotaxis
RGI145_RS02060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RGI145_RS02065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RGI145_RS02070	COG2080	2 iron, 2 sulfur cluster binding
RGI145_RS02080	COG2159	amidohydrolase
RGI145_RS02085	COG0583	DNA-binding transcription factor activity
RGI145_RS02140	COG0697	spore germination
RGI145_RS02150	COG2378	regulation of single-species biofilm formation
RGI145_RS02165	COG4974	Belongs to the 'phage' integrase family
RGI145_RS02175	COG0116	Belongs to the methyltransferase superfamily
RGI145_RS02205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RGI145_RS02220	COG0745	RESPONSE REGULATOR receiver
RGI145_RS02245	COG0277	FAD linked oxidase domain protein
RGI145_RS02250	COG2376	Dihydroxyacetone kinase
RGI145_RS02255	COG0625	glutathione transferase activity
RGI145_RS02265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RGI145_RS02270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RGI145_RS02275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RGI145_RS02290	COG0443	Heat shock 70 kDa protein
RGI145_RS02320	COG0297	glycogen (starch) synthase activity
RGI145_RS02325	COG0312	modulator of DNA gyrase
RGI145_RS02330	COG0612	Peptidase, M16
RGI145_RS02350	COG0490	domain, Protein
RGI145_RS02350	COG0471	metal ion transport
RGI145_RS02355	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
RGI145_RS02360	COG3479	Phenolic acid decarboxylase
RGI145_RS02400	COG3181	Tripartite tricarboxylate transporter family receptor
RGI145_RS02415	COG5265	(ABC) transporter
RGI145_RS02425	COG2816	NAD+ diphosphatase activity
RGI145_RS02440	COG3293	Transposase
RGI145_RS02445	COG0138	bifunctional purine biosynthesis protein purh
RGI145_RS02480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RGI145_RS02490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RGI145_RS02495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RGI145_RS02505	COG1660	Displays ATPase and GTPase activities
RGI145_RS02520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RGI145_RS02525	COG2116	formate transmembrane transporter activity
RGI145_RS02530	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RGI145_RS02535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS02545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RGI145_RS02550	COG1802	Transcriptional regulator
RGI145_RS02555	COG4166	transmembrane transport
RGI145_RS02565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS02580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS02585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RGI145_RS02605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RGI145_RS02610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RGI145_RS02615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RGI145_RS02620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RGI145_RS02625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RGI145_RS02640	COG1051	belongs to the nudix hydrolase family
RGI145_RS02650	COG0793	Belongs to the peptidase S41A family
RGI145_RS02655	COG4942	peptidase
RGI145_RS02660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RGI145_RS02665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RGI145_RS02670	COG1234	tRNA 3'-trailer cleavage
RGI145_RS02675	COG0398	Pfam SNARE associated Golgi protein
RGI145_RS02680	COG1595	DNA-templated transcription, initiation
RGI145_RS02700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGI145_RS02715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS02735	COG1278	Cold shock
RGI145_RS02750	COG3181	Tripartite tricarboxylate transporter family receptor
RGI145_RS02755	COG1414	Transcriptional regulator
RGI145_RS02760	COG1082	Xylose isomerase domain protein TIM barrel
RGI145_RS02765	COG2113	Glycine betaine
RGI145_RS02785	COG1064	alcohol dehydrogenase
RGI145_RS02805	COG3639	organic phosphonate transmembrane transporter activity
RGI145_RS02810	COG3639	organic phosphonate transmembrane transporter activity
RGI145_RS02820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RGI145_RS02860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RGI145_RS02865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RGI145_RS02900	COG2354	Protein conserved in bacteria
RGI145_RS02905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGI145_RS02910	COG0747	negative chemotaxis
RGI145_RS02925	COG1573	uracil-dna glycosylase
RGI145_RS02940	COG2902	Dehydrogenase
RGI145_RS02955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RGI145_RS02975	COG0492	ferredoxin-NADP+ reductase activity
RGI145_RS02980	COG1278	Cold shock
RGI145_RS02985	COG1846	Transcriptional regulator
RGI145_RS02990	COG1764	response to oxidative stress
RGI145_RS03000	COG3178	'Phosphotransferase
RGI145_RS03005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RGI145_RS03010	COG0737	Belongs to the 5'-nucleotidase family
RGI145_RS03015	COG1744	ABC transporter substrate-binding protein PnrA-like
RGI145_RS03020	COG3845	ABC transporter
RGI145_RS03025	COG4603	Belongs to the binding-protein-dependent transport system permease family
RGI145_RS03030	COG1079	Belongs to the binding-protein-dependent transport system permease family
RGI145_RS03035	COG0295	cytidine deaminase activity
RGI145_RS03055	COG0625	glutathione transferase activity
RGI145_RS03085	COG1733	regulation of RNA biosynthetic process
RGI145_RS03090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RGI145_RS03105	COG3387	PFAM Glycoside hydrolase 15-related
RGI145_RS03110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RGI145_RS03140	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RGI145_RS03145	COG0156	8-amino-7-oxononanoate synthase activity
RGI145_RS03170	COG0408	coproporphyrinogen oxidase activity
RGI145_RS03185	COG2857	Cytochrome c1
RGI145_RS03185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RGI145_RS03190	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RGI145_RS03200	COG0412	Dienelactone hydrolase
RGI145_RS03235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGI145_RS03240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RGI145_RS03250	COG1496	oxidoreductase activity
RGI145_RS03290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RGI145_RS03295	COG0328	RNA-DNA hybrid ribonuclease activity
RGI145_RS03305	COG3617	BRO family, N-terminal domain
RGI145_RS03335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RGI145_RS03345	COG1126	abc transporter atp-binding protein
RGI145_RS03355	COG0047	phosphoribosylformylglycinamidine synthase activity
RGI145_RS03370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RGI145_RS03385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RGI145_RS03395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RGI145_RS03400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS03405	COG0840	transmembrane signaling receptor activity
RGI145_RS03410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGI145_RS03420	COG0384	phenazine biosynthesis protein PhzF
RGI145_RS03425	COG0861	Integral membrane protein TerC family
RGI145_RS03430	COG0861	Integral membrane protein TerC family
RGI145_RS03440	COG2003	Belongs to the UPF0758 family
RGI145_RS03445	COG2271	Major facilitator Superfamily
RGI145_RS03455	COG1538	Outer membrane efflux protein
RGI145_RS03465	COG2814	Major facilitator Superfamily
RGI145_RS03470	COG1566	PFAM secretion protein HlyD family protein
RGI145_RS03480	COG0288	reversible hydration of carbon dioxide
RGI145_RS03485	COG0024	Methionine aminopeptidase
RGI145_RS03490	COG0477	Major facilitator Superfamily
RGI145_RS03495	COG5001	Diguanylate cyclase
RGI145_RS03500	COG0366	Alpha amylase catalytic
RGI145_RS03515	COG1902	pentaerythritol trinitrate reductase activity
RGI145_RS03520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RGI145_RS03540	COG0625	glutathione transferase activity
RGI145_RS03545	COG0588	phosphoglycerate mutase activity
RGI145_RS03550	COG2818	Glycosylase
RGI145_RS03560	COG1764	response to oxidative stress
RGI145_RS03565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RGI145_RS03570	COG0193	aminoacyl-tRNA hydrolase activity
RGI145_RS03580	COG1393	Belongs to the ArsC family
RGI145_RS03585	COG0436	Aminotransferase
RGI145_RS03590	COG0405	Gamma-glutamyltransferase
RGI145_RS03610	COG1058	Belongs to the CinA family
RGI145_RS03610	COG1546	Belongs to the CinA family
RGI145_RS03615	COG0494	nUDIX hydrolase
RGI145_RS03620	COG1530	ribonuclease E activity
RGI145_RS03620	COG1530	ribonuclease E activity
RGI145_RS03625	COG2814	Major facilitator Superfamily
RGI145_RS03635	COG1295	ribonuclease BN
RGI145_RS03645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RGI145_RS03655	COG2309	aminopeptidase activity
RGI145_RS03660	COG2766	serine protein kinase
RGI145_RS03665	COG2718	Belongs to the UPF0229 family
RGI145_RS03670	COG2719	SpoVR family
RGI145_RS03675	COG1942	4-Oxalocrotonate Tautomerase
RGI145_RS03680	COG0488	(ABC) transporter
RGI145_RS03740	COG0297	glycogen (starch) synthase activity
RGI145_RS03785	COG3706	GGDEF domain
RGI145_RS03805	COG3135	benzoate transporter
RGI145_RS03815	COG1053	succinate dehydrogenase
RGI145_RS03825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RGI145_RS03840	COG2003	Belongs to the UPF0758 family
RGI145_RS03850	COG0488	(ABC) transporter
RGI145_RS03855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RGI145_RS03860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RGI145_RS03865	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RGI145_RS03880	COG0277	FAD linked oxidase domain protein
RGI145_RS03900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RGI145_RS03905	COG0747	negative chemotaxis
RGI145_RS03915	COG0747	negative chemotaxis
RGI145_RS03920	COG0601	transmembrane transport
RGI145_RS03925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS03940	COG1132	(ABC) transporter
RGI145_RS03945	COG0444	Belongs to the ABC transporter superfamily
RGI145_RS03965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RGI145_RS03980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RGI145_RS03985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RGI145_RS03995	COG4208	sulfate ABC transporter
RGI145_RS04000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RGI145_RS04010	COG0484	heat shock protein binding
RGI145_RS04015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RGI145_RS04020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGI145_RS04060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS04060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RGI145_RS04070	COG1294	oxidase, subunit
RGI145_RS04075	COG1271	oxidase subunit
RGI145_RS04085	COG2226	methyltransferase
RGI145_RS04095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RGI145_RS04105	COG0668	transmembrane transport
RGI145_RS04115	COG2086	electron transfer activity
RGI145_RS04125	COG1250	3-hydroxyacyl-CoA dehydrogenase
RGI145_RS04145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RGI145_RS04150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RGI145_RS04150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RGI145_RS04155	COG0454	-acetyltransferase
RGI145_RS04165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RGI145_RS04175	COG0438	transferase activity, transferring glycosyl groups
RGI145_RS04185	COG1131	(ABC) transporter
RGI145_RS04200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RGI145_RS04200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RGI145_RS04205	COG1442	glycosyl transferase family 8
RGI145_RS04225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RGI145_RS04240	COG0778	Nitroreductase
RGI145_RS04245	COG1289	transmembrane transporter activity
RGI145_RS04250	COG3162	membrane
RGI145_RS04285	COG0477	Major facilitator Superfamily
RGI145_RS04300	COG1410	methionine synthase
RGI145_RS04300	COG0646	methionine synthase
RGI145_RS04305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RGI145_RS04315	COG2096	Adenosyltransferase
RGI145_RS04320	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RGI145_RS04330	COG5001	Diguanylate cyclase
RGI145_RS04340	COG0720	synthase
RGI145_RS04350	COG0602	queuosine metabolic process
RGI145_RS04370	COG2070	2-Nitropropane dioxygenase
RGI145_RS04375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RGI145_RS04385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RGI145_RS04400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RGI145_RS04405	COG2204	response regulator
RGI145_RS04410	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RGI145_RS04420	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RGI145_RS04425	COG1766	The M ring may be actively involved in energy transduction
RGI145_RS04440	COG1749	Flagellar hook protein flgE
RGI145_RS04480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RGI145_RS04515	COG0688	phosphatidylethanolamine metabolic process
RGI145_RS04520	COG1183	phosphatidylcholine synthase activity
RGI145_RS04545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RGI145_RS04560	COG0753	catalase activity
RGI145_RS04590	COG0009	L-threonylcarbamoyladenylate synthase
RGI145_RS04600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RGI145_RS04605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RGI145_RS04630	COG0488	(ABC) transporter
RGI145_RS04645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RGI145_RS04660	COG1686	Belongs to the peptidase S11 family
RGI145_RS04665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RGI145_RS04675	COG0105	UTP biosynthetic process
RGI145_RS04685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RGI145_RS04690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RGI145_RS04700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RGI145_RS04705	COG0628	permease
RGI145_RS04715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RGI145_RS04720	COG0248	Ppx GppA phosphatase
RGI145_RS04730	COG0477	Major facilitator Superfamily
RGI145_RS04735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RGI145_RS04735	COG1648	precorrin-2 dehydrogenase activity
RGI145_RS04740	COG0243	molybdopterin cofactor binding
RGI145_RS04750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RGI145_RS04755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RGI145_RS04760	COG1116	anion transmembrane transporter activity
RGI145_RS04765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGI145_RS04770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGI145_RS04775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGI145_RS04775	COG1116	anion transmembrane transporter activity
RGI145_RS04810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RGI145_RS04815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RGI145_RS04830	COG3128	pkhd-type hydroxylase
RGI145_RS04865	COG0302	gtp cyclohydrolase
RGI145_RS04870	COG2967	ApaG domain
RGI145_RS04880	COG1605	Chorismate mutase
RGI145_RS04880	COG0287	Prephenate dehydrogenase
RGI145_RS04895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGI145_RS04905	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGI145_RS04910	COG1177	transmembrane transport
RGI145_RS04915	COG4191	Histidine kinase
RGI145_RS04915	COG0784	Response regulator, receiver
RGI145_RS04930	COG0277	FAD linked oxidase domain protein
RGI145_RS04935	COG0277	FAD linked oxidase domain protein
RGI145_RS04940	COG0247	lactate metabolic process
RGI145_RS04945	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RGI145_RS04960	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS04965	COG2983	Belongs to the UPF0260 family
RGI145_RS04990	COG0167	dihydroorotate dehydrogenase activity
RGI145_RS05015	COG1902	pentaerythritol trinitrate reductase activity
RGI145_RS05025	COG2081	HI0933 family
RGI145_RS05035	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS05055	COG1566	PFAM secretion protein HlyD family protein
RGI145_RS05065	COG1185	polyribonucleotide nucleotidyltransferase activity
RGI145_RS05085	COG1175	transmembrane transport
RGI145_RS05095	COG3842	ATPase activity
RGI145_RS05100	COG1070	Carbohydrate kinase
RGI145_RS05105	COG0246	Mannitol dehydrogenase
RGI145_RS05110	COG2271	Major facilitator Superfamily
RGI145_RS05115	COG1063	alcohol dehydrogenase
RGI145_RS05120	COG1312	Catalyzes the dehydration of D-mannonate
RGI145_RS05125	COG0246	Mannitol dehydrogenase
RGI145_RS05130	COG1802	Transcriptional regulator
RGI145_RS05135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RGI145_RS05145	COG1201	RNA secondary structure unwinding
RGI145_RS05155	COG1414	Transcriptional regulator
RGI145_RS05160	COG3734	2-keto-3-deoxy-galactonokinase
RGI145_RS05165	COG0800	Aldolase
RGI145_RS05170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RGI145_RS05200	COG0765	amino acid transport
RGI145_RS05205	COG0765	amino acid transport
RGI145_RS05210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS05220	COG2945	thiolester hydrolase activity
RGI145_RS05235	COG1104	cysteine desulfurase activity
RGI145_RS05245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RGI145_RS05250	COG0482	sulfurtransferase activity
RGI145_RS05260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RGI145_RS05285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RGI145_RS05290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RGI145_RS05320	COG4191	Histidine kinase
RGI145_RS05320	COG0784	Response regulator, receiver
RGI145_RS05340	COG2059	Chromate
RGI145_RS05345	COG1620	l-lactate permease
RGI145_RS05360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS05365	COG0590	tRNA wobble adenosine to inosine editing
RGI145_RS05370	COG0028	Belongs to the TPP enzyme family
RGI145_RS05380	COG1121	(ABC) transporter
RGI145_RS05385	COG2733	membrane
RGI145_RS05425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RGI145_RS05430	COG0251	oxidation-reduction process
RGI145_RS05435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGI145_RS05455	COG0560	Phosphoserine phosphatase
RGI145_RS05455	COG3830	Belongs to the UPF0237 family
RGI145_RS05460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RGI145_RS05465	COG0028	Belongs to the TPP enzyme family
RGI145_RS05475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RGI145_RS05505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RGI145_RS05535	COG2326	polyphosphate kinase activity
RGI145_RS05550	COG2010	Cytochrome c
RGI145_RS05550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RGI145_RS05555	COG0747	negative chemotaxis
RGI145_RS05565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RGI145_RS05575	COG1686	Belongs to the peptidase S11 family
RGI145_RS05595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RGI145_RS05615	COG0280	phosphate acetyltransferase
RGI145_RS05615	COG0281	malic enzyme
RGI145_RS05625	COG0321	lipoyl(octanoyl) transferase activity
RGI145_RS05640	COG0444	Belongs to the ABC transporter superfamily
RGI145_RS05650	COG0778	Nitroreductase
RGI145_RS05655	COG0673	inositol 2-dehydrogenase activity
RGI145_RS05665	COG0513	Belongs to the DEAD box helicase family
RGI145_RS05680	COG1254	Belongs to the acylphosphatase family
RGI145_RS05695	COG0564	pseudouridine synthase activity
RGI145_RS05705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RGI145_RS05715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RGI145_RS05740	COG0745	RESPONSE REGULATOR receiver
RGI145_RS05745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RGI145_RS05765	COG0643	Histidine kinase
RGI145_RS05765	COG2198	Histidine kinase
RGI145_RS05765	COG0784	Response regulator, receiver
RGI145_RS05780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RGI145_RS05785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RGI145_RS05790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RGI145_RS05795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RGI145_RS05810	COG1125	glycine betaine transport
RGI145_RS05815	COG1174	glycine betaine transport
RGI145_RS05820	COG1732	Glycine betaine
RGI145_RS05850	COG0400	carboxylic ester hydrolase activity
RGI145_RS05855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RGI145_RS05875	COG1573	uracil-dna glycosylase
RGI145_RS05880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RGI145_RS05890	COG2755	lipolytic protein G-D-S-L family
RGI145_RS05895	COG4181	ATPase activity
RGI145_RS05900	COG0577	efflux transmembrane transporter activity
RGI145_RS05900	COG1136	(ABC) transporter
RGI145_RS05910	COG4106	trans-aconitate 2-methyltransferase activity
RGI145_RS05915	COG2814	Major facilitator Superfamily
RGI145_RS05925	COG0670	Belongs to the BI1 family
RGI145_RS05930	COG1329	Transcriptional regulator
RGI145_RS05940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RGI145_RS05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS05960	COG0765	amino acid transport
RGI145_RS05965	COG1126	abc transporter atp-binding protein
RGI145_RS06000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RGI145_RS06015	COG4774	siderophore transport
RGI145_RS06020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RGI145_RS06025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RGI145_RS06030	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RGI145_RS06040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RGI145_RS06045	COG0181	hydroxymethylbilane synthase activity
RGI145_RS06080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGI145_RS06090	COG0596	Alpha beta hydrolase
RGI145_RS06110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGI145_RS06120	COG0784	Response regulator, receiver
RGI145_RS06120	COG4191	Histidine kinase
RGI145_RS06125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGI145_RS06135	COG0306	phosphate transporter
RGI145_RS06145	COG2824	Alkylphosphonate utilization operon protein PhnA
RGI145_RS06155	COG0450	alkyl hydroperoxide reductase
RGI145_RS06160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RGI145_RS06170	COG3781	membrane
RGI145_RS06180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RGI145_RS06195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS06205	COG0154	amidase activity
RGI145_RS06250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RGI145_RS06260	COG3395	kinase activity
RGI145_RS06270	COG0438	transferase activity, transferring glycosyl groups
RGI145_RS06300	COG1706	bacterial-type flagellum-dependent cell motility
RGI145_RS06315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RGI145_RS06340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RGI145_RS06345	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RGI145_RS06350	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS06355	COG3474	cytochrome
RGI145_RS06360	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RGI145_RS06370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RGI145_RS06375	COG0343	queuine tRNA-ribosyltransferase activity
RGI145_RS06380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RGI145_RS06390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RGI145_RS06400	COG2894	cell division
RGI145_RS06405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RGI145_RS06410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RGI145_RS06425	COG0494	nUDIX hydrolase
RGI145_RS06430	COG2169	Transcriptional regulator
RGI145_RS06430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RGI145_RS06440	COG0469	pyruvate kinase activity
RGI145_RS06505	COG0563	adenylate kinase activity
RGI145_RS06520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RGI145_RS06540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RGI145_RS06545	COG0242	peptide deformylase activity
RGI145_RS06560	COG2885	chlorophyll binding
RGI145_RS06560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RGI145_RS06565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RGI145_RS06595	COG0071	Belongs to the small heat shock protein (HSP20) family
RGI145_RS06600	COG0254	rRNA binding
RGI145_RS06605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RGI145_RS06615	COG3591	Belongs to the peptidase S1B family
RGI145_RS06615	COG1864	DNA RNA non-specific endonuclease
RGI145_RS06640	COG0463	Glycosyl transferase, family 2
RGI145_RS06650	COG2226	methyltransferase
RGI145_RS06670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGI145_RS06680	COG0436	Aminotransferase
RGI145_RS06690	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RGI145_RS06695	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RGI145_RS06715	COG0719	Fe-S assembly protein
RGI145_RS06720	COG0396	ATPase activity
RGI145_RS06725	COG0719	Fe-S assembly protein
RGI145_RS06730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RGI145_RS06735	COG0822	iron-sulfur transferase activity
RGI145_RS06740	COG2151	metal-sulfur cluster biosynthetic enzyme
RGI145_RS06745	COG0316	Belongs to the HesB IscA family
RGI145_RS06755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RGI145_RS06765	COG0513	Belongs to the DEAD box helicase family
RGI145_RS06775	COG1803	Methylglyoxal synthase
RGI145_RS06780	COG0583	DNA-binding transcription factor activity
RGI145_RS06790	COG0187	DNA topoisomerase II activity
RGI145_RS06795	COG0783	Belongs to the Dps family
RGI145_RS06800	COG2814	Major facilitator Superfamily
RGI145_RS06810	COG2252	PERMEase
RGI145_RS06815	COG4251	negative regulation of phosphorylation
RGI145_RS06825	COG0174	glutamine synthetase
RGI145_RS06835	COG0436	Aminotransferase
RGI145_RS06855	COG3181	Tripartite tricarboxylate transporter family receptor
RGI145_RS06865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RGI145_RS06870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RGI145_RS06875	COG1797	cobyrinic acid a,c-diamide synthase activity
RGI145_RS06880	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
RGI145_RS06950	COG1492	cobalamin metabolic process
RGI145_RS06955	COG1305	Transglutaminase-like
RGI145_RS06975	COG1473	amidohydrolase
RGI145_RS06990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RGI145_RS06995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RGI145_RS07000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RGI145_RS07005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RGI145_RS07020	COG3243	poly(R)-hydroxyalkanoic acid synthase
RGI145_RS07030	COG0436	Aminotransferase
RGI145_RS07040	COG1494	fructose-1,6-bisphosphatase
RGI145_RS07045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RGI145_RS07045	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RGI145_RS07050	COG1064	alcohol dehydrogenase
RGI145_RS07055	COG0655	NAD(P)H dehydrogenase (quinone) activity
RGI145_RS07060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RGI145_RS07065	COG0126	phosphoglycerate kinase activity
RGI145_RS07090	COG0235	Class ii aldolase
RGI145_RS07095	COG1285	pathogenesis
RGI145_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS07135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RGI145_RS07140	COG0594	ribonuclease P activity
RGI145_RS07145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RGI145_RS07150	COG0706	membrane insertase activity
RGI145_RS07155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RGI145_RS07160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RGI145_RS07165	COG0596	Alpha beta hydrolase
RGI145_RS07170	COG2171	N-acyltransferase activity
RGI145_RS07175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RGI145_RS07190	COG0101	tRNA pseudouridine synthase activity
RGI145_RS07195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RGI145_RS07200	COG0242	peptide deformylase activity
RGI145_RS07220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RGI145_RS07225	COG1137	ATPase activity
RGI145_RS07240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RGI145_RS07240	COG0517	IMP dehydrogenase activity
RGI145_RS07305	COG0297	glycogen (starch) synthase activity
RGI145_RS07310	COG0859	PFAM glycosyl transferase family 9
RGI145_RS07315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RGI145_RS07320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RGI145_RS07325	COG1132	(ABC) transporter
RGI145_RS07335	COG1940	carbohydrate kinase activity
RGI145_RS07340	COG0425	Belongs to the sulfur carrier protein TusA family
RGI145_RS07355	COG0142	geranyltranstransferase activity
RGI145_RS07360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RGI145_RS07365	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RGI145_RS07375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RGI145_RS07380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RGI145_RS07385	COG0259	pyridoxamine-phosphate oxidase activity
RGI145_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS07405	COG0747	negative chemotaxis
RGI145_RS07410	COG1473	amidohydrolase
RGI145_RS07415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RGI145_RS07420	COG2204	response regulator
RGI145_RS07425	COG4191	Histidine kinase
RGI145_RS07430	COG1301	dicarboxylic acid transport
RGI145_RS07435	COG2130	NADP-dependent
RGI145_RS07440	COG1763	Mo-molybdopterin cofactor biosynthetic process
RGI145_RS07445	COG0303	'Molybdopterin
RGI145_RS07450	COG0746	molybdenum cofactor guanylyltransferase activity
RGI145_RS07455	COG2252	PERMEase
RGI145_RS07460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RGI145_RS07465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RGI145_RS07475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RGI145_RS07495	COG1192	Involved in chromosome partitioning
RGI145_RS07510	COG2226	methyltransferase
RGI145_RS07515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RGI145_RS07520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RGI145_RS07530	COG0784	Response regulator, receiver
RGI145_RS07530	COG4191	Histidine kinase
RGI145_RS07545	COG0527	aspartate kinase activity
RGI145_RS07560	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RGI145_RS07570	COG0124	histidyl-tRNA synthetase
RGI145_RS07575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RGI145_RS07580	COG2890	protein-(glutamine-N5) methyltransferase activity
RGI145_RS07595	COG0438	transferase activity, transferring glycosyl groups
RGI145_RS07605	COG0542	response to heat
RGI145_RS07640	COG4178	(ABC) transporter
RGI145_RS07655	COG0784	Response regulator, receiver
RGI145_RS07665	COG1595	DNA-templated transcription, initiation
RGI145_RS07700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RGI145_RS07705	COG0228	four-way junction DNA binding
RGI145_RS07710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RGI145_RS07715	COG0336	Belongs to the RNA methyltransferase TrmD family
RGI145_RS07720	COG0335	large ribosomal subunit rRNA binding
RGI145_RS07725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RGI145_RS07730	COG0066	3-isopropylmalate dehydratase activity
RGI145_RS07750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RGI145_RS07780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RGI145_RS07805	COG4988	ABC transporter
RGI145_RS07810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RGI145_RS07820	COG0514	ATP-dependent DNA helicase (RecQ)
RGI145_RS07825	COG2906	2 iron, 2 sulfur cluster binding
RGI145_RS07835	COG4178	(ABC) transporter
RGI145_RS07850	COG2885	chlorophyll binding
RGI145_RS07850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RGI145_RS07855	COG2226	methyltransferase
RGI145_RS07865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RGI145_RS07870	COG0793	Belongs to the peptidase S41A family
RGI145_RS07875	COG0557	exoribonuclease II activity
RGI145_RS07880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RGI145_RS07885	COG0758	DNA mediated transformation
RGI145_RS07890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RGI145_RS07895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RGI145_RS07900	COG0540	Belongs to the ATCase OTCase family
RGI145_RS07905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RGI145_RS07910	COG0668	transmembrane transport
RGI145_RS07915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RGI145_RS07920	COG0154	amidase activity
RGI145_RS07925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RGI145_RS07930	COG2314	TM2 domain
RGI145_RS07935	COG0625	glutathione transferase activity
RGI145_RS07970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RGI145_RS07975	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RGI145_RS07990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RGI145_RS08010	COG0667	Aldo Keto reductase
RGI145_RS08030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RGI145_RS08050	COG1473	amidohydrolase
RGI145_RS08055	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RGI145_RS08075	COG0628	permease
RGI145_RS08080	COG3045	CreA protein
RGI145_RS08085	COG4533	DNA binding
RGI145_RS08095	COG0405	Gamma-glutamyltransferase
RGI145_RS08100	COG0792	nuclease activity
RGI145_RS08110	COG0606	chelatase, subunit chli
RGI145_RS08125	COG4608	Belongs to the ABC transporter superfamily
RGI145_RS08130	COG0747	negative chemotaxis
RGI145_RS08135	COG0601	transmembrane transport
RGI145_RS08140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS08210	COG1253	flavin adenine dinucleotide binding
RGI145_RS08215	COG1215	transferase activity, transferring glycosyl groups
RGI145_RS08220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RGI145_RS08225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGI145_RS08230	COG0405	Gamma-glutamyltransferase
RGI145_RS08240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RGI145_RS08265	COG0402	S-adenosylhomocysteine deaminase activity
RGI145_RS08270	COG0405	Gamma-glutamyltransferase
RGI145_RS08275	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RGI145_RS08280	COG3454	Phosphonate metabolism
RGI145_RS08300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RGI145_RS08315	COG0525	valine-tRNA ligase activity
RGI145_RS08320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RGI145_RS08330	COG0129	dihydroxy-acid dehydratase activity
RGI145_RS08335	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RGI145_RS08340	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RGI145_RS08360	COG0708	Exodeoxyribonuclease III
RGI145_RS08365	COG0316	Belongs to the HesB IscA family
RGI145_RS08370	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RGI145_RS08375	COG0018	arginyl-trna synthetase
RGI145_RS08385	COG1472	Belongs to the glycosyl hydrolase 3 family
RGI145_RS08390	COG1994	Peptidase M50
RGI145_RS08395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RGI145_RS08400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RGI145_RS08405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RGI145_RS08410	COG0805	protein transport
RGI145_RS08415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RGI145_RS08435	COG0123	including yeast histone deacetylase and acetoin utilization protein
RGI145_RS08440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RGI145_RS08440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RGI145_RS08465	COG2204	response regulator
RGI145_RS08470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RGI145_RS08480	COG1923	regulation of RNA biosynthetic process
RGI145_RS08485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RGI145_RS08490	COG0483	inositol monophosphate 1-phosphatase activity
RGI145_RS08495	COG3956	TIGRFAM MazG family protein
RGI145_RS08500	COG1234	tRNA 3'-trailer cleavage
RGI145_RS08505	COG0084	hydrolase, TatD family'
RGI145_RS08515	COG0470	DNA polymerase III
RGI145_RS08520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RGI145_RS08525	COG1686	Belongs to the peptidase S11 family
RGI145_RS08535	COG2951	lytic endotransglycosylase activity
RGI145_RS08550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RGI145_RS08560	COG0477	Major facilitator Superfamily
RGI145_RS08565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RGI145_RS08570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RGI145_RS08575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RGI145_RS08590	COG1131	(ABC) transporter
RGI145_RS08620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RGI145_RS08645	COG0395	ABC-type sugar transport system, permease component
RGI145_RS08650	COG3842	ATPase activity
RGI145_RS08700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RGI145_RS08705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RGI145_RS08710	COG0629	single-stranded DNA binding
RGI145_RS08715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RGI145_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS08735	COG1862	Preprotein translocase
RGI145_RS08775	COG3608	succinylglutamate desuccinylase aspartoacylase
RGI145_RS08775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RGI145_RS08780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RGI145_RS08795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RGI145_RS08815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RGI145_RS08820	COG0416	fatty acid biosynthetic process
RGI145_RS08825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RGI145_RS08840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RGI145_RS08845	COG2814	Major facilitator Superfamily
RGI145_RS08850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RGI145_RS08855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RGI145_RS08860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RGI145_RS08865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RGI145_RS08865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RGI145_RS08875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RGI145_RS08875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RGI145_RS08880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RGI145_RS08885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RGI145_RS08890	COG0698	ribose 5-phosphate isomerase
RGI145_RS08900	COG0113	porphobilinogen synthase activity
RGI145_RS08905	COG0657	acetylesterase activity
RGI145_RS08920	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RGI145_RS08930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RGI145_RS08935	COG1381	Involved in DNA repair and RecF pathway recombination
RGI145_RS08940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RGI145_RS08945	COG0571	ribonuclease III activity
RGI145_RS08950	COG0681	Belongs to the peptidase S26 family
RGI145_RS08955	COG0736	holo-[acyl-carrier-protein] synthase activity
RGI145_RS08960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RGI145_RS08965	COG1758	RNA polymerase activity
RGI145_RS08975	COG0747	negative chemotaxis
RGI145_RS08985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RGI145_RS08995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RGI145_RS09000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGI145_RS09015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RGI145_RS09020	COG1546	Belongs to the CinA family
RGI145_RS09020	COG1058	Belongs to the CinA family
RGI145_RS09030	COG0583	DNA-binding transcription factor activity
RGI145_RS09035	COG1380	Effector of murein hydrolase LrgA
RGI145_RS09045	COG0625	glutathione transferase activity
RGI145_RS09050	COG2867	negative regulation of translational initiation
RGI145_RS09055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RGI145_RS09060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RGI145_RS09075	COG0508	dehydrogenase complex catalyzes the overall conversion of
RGI145_RS09080	COG0022	dehydrogenase e1 component
RGI145_RS09080	COG0508	dehydrogenase complex catalyzes the overall conversion of
RGI145_RS09085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RGI145_RS09095	COG0148	phosphopyruvate hydratase activity
RGI145_RS09110	COG0504	CTP synthase activity
RGI145_RS09115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RGI145_RS09120	COG0149	triose-phosphate isomerase activity
RGI145_RS09125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RGI145_RS09130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RGI145_RS09135	COG0134	indole-3-glycerol-phosphate synthase activity
RGI145_RS09140	COG0315	cyclic pyranopterin monophosphate synthase activity
RGI145_RS09145	COG0303	'Molybdopterin
RGI145_RS09150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RGI145_RS09155	COG2333	competence protein COMEC
RGI145_RS09155	COG0658	competence protein
RGI145_RS09160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RGI145_RS09165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGI145_RS09175	COG0583	DNA-binding transcription factor activity
RGI145_RS09185	COG3384	dioxygenase
RGI145_RS09200	COG3106	COG3106 Predicted ATPase
RGI145_RS09205	COG0346	lactoylglutathione lyase activity
RGI145_RS09210	COG0667	Aldo Keto reductase
RGI145_RS09220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RGI145_RS09230	COG1126	abc transporter atp-binding protein
RGI145_RS09235	COG0765	amino acid transport
RGI145_RS09240	COG0765	amino acid transport
RGI145_RS09255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RGI145_RS09260	COG2986	histidine ammonia-lyase
RGI145_RS09265	COG3300	MHYT domain
RGI145_RS09265	COG5001	Diguanylate cyclase
RGI145_RS09290	COG4608	Belongs to the ABC transporter superfamily
RGI145_RS09295	COG0444	Belongs to the ABC transporter superfamily
RGI145_RS09300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS09305	COG0601	transmembrane transport
RGI145_RS09310	COG0747	negative chemotaxis
RGI145_RS09315	COG0747	negative chemotaxis
RGI145_RS09335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGI145_RS09345	COG0584	glycerophosphoryl diester phosphodiesterase
RGI145_RS09360	COG1473	amidohydrolase
RGI145_RS09380	COG1011	Hydrolase
RGI145_RS09400	COG0142	geranyltranstransferase activity
RGI145_RS09410	COG2264	protein methyltransferase activity
RGI145_RS09420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RGI145_RS09430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS09435	COG0519	Catalyzes the synthesis of GMP from XMP
RGI145_RS09435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RGI145_RS09445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RGI145_RS09445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RGI145_RS09455	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RGI145_RS09495	COG0018	arginyl-trna synthetase
RGI145_RS09535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGI145_RS09565	COG3621	Patatin-like phospholipase
RGI145_RS09615	COG1230	cation diffusion facilitator family transporter
RGI145_RS09625	COG0785	Cytochrome C biogenesis protein
RGI145_RS09630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RGI145_RS09655	COG0431	NADPH-dependent FMN reductase
RGI145_RS09660	COG2072	flavoprotein involved in K transport
RGI145_RS09665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RGI145_RS09685	COG2132	Multicopper oxidase
RGI145_RS09780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RGI145_RS09785	COG3617	BRO family, N-terminal domain
RGI145_RS09805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGI145_RS09815	COG1562	ergosterol biosynthetic process
RGI145_RS09820	COG1562	ergosterol biosynthetic process
RGI145_RS09825	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RGI145_RS09830	COG1657	PFAM Prenyltransferase squalene oxidase
RGI145_RS09885	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
RGI145_RS09885	COG0028	Belongs to the TPP enzyme family
RGI145_RS09935	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RGI145_RS09940	COG0583	DNA-binding transcription factor activity
RGI145_RS09975	COG2989	Protein conserved in bacteria
RGI145_RS09995	COG0583	DNA-binding transcription factor activity
RGI145_RS10000	COG0450	alkyl hydroperoxide reductase
RGI145_RS10005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RGI145_RS10010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RGI145_RS10030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RGI145_RS10040	COG0693	protein deglycase activity
RGI145_RS10065	COG0747	negative chemotaxis
RGI145_RS10070	COG1473	amidohydrolase
RGI145_RS10080	COG1671	Belongs to the UPF0178 family
RGI145_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS10115	COG0564	pseudouridine synthase activity
RGI145_RS10130	COG0673	inositol 2-dehydrogenase activity
RGI145_RS10140	COG3842	ATPase activity
RGI145_RS10145	COG0235	Class ii aldolase
RGI145_RS10165	COG1794	racemase activity, acting on amino acids and derivatives
RGI145_RS10175	COG0473	3-isopropylmalate dehydrogenase activity
RGI145_RS10180	COG1252	NADH dehydrogenase
RGI145_RS10205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RGI145_RS10220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS10225	COG0121	glutamine amidotransferase
RGI145_RS10240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RGI145_RS10255	COG4251	negative regulation of phosphorylation
RGI145_RS10255	COG5001	Diguanylate cyclase
RGI145_RS10255	COG2203	Gaf domain
RGI145_RS10255	COG3706	GGDEF domain
RGI145_RS10275	COG1012	belongs to the aldehyde dehydrogenase family
RGI145_RS10280	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS10315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RGI145_RS10320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RGI145_RS10335	COG1988	membrane-bound metal-dependent
RGI145_RS10345	COG0492	ferredoxin-NADP+ reductase activity
RGI145_RS10355	COG3494	Protein of unknown function (DUF1009)
RGI145_RS10360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGI145_RS10365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RGI145_RS10370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGI145_RS10380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RGI145_RS10385	COG0750	zinc metalloprotease
RGI145_RS10390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RGI145_RS10400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RGI145_RS10405	COG0233	cytoplasmic translational termination
RGI145_RS10410	COG0528	UMP kinase activity
RGI145_RS10415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RGI145_RS10420	COG0052	Belongs to the universal ribosomal protein uS2 family
RGI145_RS10450	COG1136	(ABC) transporter
RGI145_RS10460	COG0442	prolyl-tRNA aminoacylation
RGI145_RS10475	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RGI145_RS10485	COG1007	ATP synthesis coupled electron transport
RGI145_RS10500	COG0713	ATP synthesis coupled electron transport
RGI145_RS10510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGI145_RS10515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RGI145_RS10520	COG1034	ATP synthesis coupled electron transport
RGI145_RS10535	COG0649	NAD binding
RGI145_RS10545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGI145_RS10550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGI145_RS10580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RGI145_RS10585	COG0740	serine-type endopeptidase activity
RGI145_RS10590	COG0544	peptidyl-prolyl cis-trans isomerase activity
RGI145_RS10610	COG0412	Dienelactone hydrolase
RGI145_RS10630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RGI145_RS10635	COG0517	IMP dehydrogenase activity
RGI145_RS10640	COG0697	spore germination
RGI145_RS10645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RGI145_RS10650	COG2897	thiosulfate sulfurtransferase activity
RGI145_RS10655	COG0626	cystathionine gamma-synthase activity
RGI145_RS10665	COG0471	metal ion transport
RGI145_RS10670	COG0735	belongs to the Fur family
RGI145_RS10675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RGI145_RS10690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RGI145_RS10695	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGI145_RS10710	COG2814	Major facilitator Superfamily
RGI145_RS10715	COG0673	inositol 2-dehydrogenase activity
RGI145_RS10720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGI145_RS10725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGI145_RS10750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RGI145_RS10770	COG0628	permease
RGI145_RS10785	COG0351	phosphomethylpyrimidine kinase
RGI145_RS10785	COG0352	thiamine-phosphate diphosphorylase activity
RGI145_RS10790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RGI145_RS10795	COG2814	Major facilitator Superfamily
RGI145_RS10800	COG1942	4-Oxalocrotonate Tautomerase
RGI145_RS10805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RGI145_RS10810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGI145_RS10815	COG0037	tRNA processing
RGI145_RS10825	COG2885	chlorophyll binding
RGI145_RS10850	COG0824	Thioesterase
RGI145_RS10855	COG2255	four-way junction helicase activity
RGI145_RS10865	COG2814	Major facilitator Superfamily
RGI145_RS10875	COG0632	four-way junction helicase activity
RGI145_RS10880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RGI145_RS10885	COG0217	transcriptional regulatory protein
RGI145_RS10895	COG1692	metallophosphoesterase
RGI145_RS10900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RGI145_RS10925	COG1830	Aldolase
RGI145_RS10930	COG0352	thiamine-phosphate diphosphorylase activity
RGI145_RS10935	COG1253	flavin adenine dinucleotide binding
RGI145_RS10955	COG1509	lysine 2,3-aminomutase activity
RGI145_RS10960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RGI145_RS10965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RGI145_RS10970	COG0483	inositol monophosphate 1-phosphatase activity
RGI145_RS11005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RGI145_RS11010	COG1473	amidohydrolase
RGI145_RS11025	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RGI145_RS11025	COG0662	Cupin 2, conserved barrel domain protein
RGI145_RS11030	COG2235	arginine
RGI145_RS11035	COG0277	FAD linked oxidase domain protein
RGI145_RS11085	COG2814	Major facilitator Superfamily
RGI145_RS11095	COG0628	permease
RGI145_RS11105	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RGI145_RS11120	COG0772	Belongs to the SEDS family
RGI145_RS11125	COG0768	penicillin binding
RGI145_RS11150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RGI145_RS11155	COG0392	lysyltransferase activity
RGI145_RS11155	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RGI145_RS11175	COG4608	Belongs to the ABC transporter superfamily
RGI145_RS11180	COG0444	Belongs to the ABC transporter superfamily
RGI145_RS11185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS11190	COG0601	transmembrane transport
RGI145_RS11195	COG0747	negative chemotaxis
RGI145_RS11220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RGI145_RS11225	COG0511	ligase activity, forming carbon-carbon bonds
RGI145_RS11230	COG0439	Biotin carboxylase
RGI145_RS11235	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RGI145_RS11240	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RGI145_RS11245	COG1877	trehalose-phosphatase activity
RGI145_RS11270	COG1177	transmembrane transport
RGI145_RS11275	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGI145_RS11280	COG3842	ATPase activity
RGI145_RS11320	COG3706	GGDEF domain
RGI145_RS11325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RGI145_RS11330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RGI145_RS11335	COG0799	negative regulation of ribosome biogenesis
RGI145_RS11340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RGI145_RS11355	COG2982	Protein involved in outer membrane biogenesis
RGI145_RS11365	COG2813	Specifically methylates the guanine in position
RGI145_RS11370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RGI145_RS11380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RGI145_RS11385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RGI145_RS11390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RGI145_RS11395	COG1253	flavin adenine dinucleotide binding
RGI145_RS11400	COG0300	oxidoreductase activity
RGI145_RS11405	COG1561	YicC-like family, N-terminal region
RGI145_RS11410	COG0194	GDP metabolic process
RGI145_RS11425	COG3387	PFAM Glycoside hydrolase 15-related
RGI145_RS11430	COG3387	PFAM Glycoside hydrolase 15-related
RGI145_RS11435	COG5425	PFAM Usg family protein
RGI145_RS11440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RGI145_RS11445	COG0459	protein refolding
RGI145_RS11470	COG1199	ATP-dependent helicase activity
RGI145_RS11480	COG2910	NAD(P)H-binding
RGI145_RS11580	COG3507	Belongs to the glycosyl hydrolase 43 family
RGI145_RS11580	COG3693	PFAM glycoside hydrolase, family 10
RGI145_RS11580	COG2382	esterase
RGI145_RS11600	COG1643	Atp-dependent helicase
RGI145_RS11610	COG0025	NhaP-type Na H and K H
RGI145_RS11620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS11630	COG4139	cobalamin transport
RGI145_RS11635	COG1120	ATPase activity
RGI145_RS11640	COG2239	Acts as a magnesium transporter
RGI145_RS11650	COG2205	protein histidine kinase activity
RGI145_RS11690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RGI145_RS11695	COG0235	Class ii aldolase
RGI145_RS11700	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
RGI145_RS11705	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
RGI145_RS11720	COG2814	Major facilitator Superfamily
RGI145_RS11725	COG1286	toxin biosynthetic process
RGI145_RS11730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RGI145_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS11760	COG2995	paraquat-inducible protein a
RGI145_RS11765	COG3008	intermembrane lipid transfer
RGI145_RS11765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RGI145_RS11785	COG0288	reversible hydration of carbon dioxide
RGI145_RS11790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RGI145_RS11800	COG2076	Multidrug Resistance protein
RGI145_RS11810	COG0438	transferase activity, transferring glycosyl groups
RGI145_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS11840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RGI145_RS11840	COG0574	Belongs to the PEP-utilizing enzyme family
RGI145_RS11850	COG0752	glycyl-tRNA synthetase alpha subunit
RGI145_RS11865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RGI145_RS11865	COG0616	signal peptide processing
RGI145_RS11875	COG0747	negative chemotaxis
RGI145_RS11885	COG1832	CoA-binding protein
RGI145_RS11890	COG3416	Protein conserved in bacteria
RGI145_RS11900	COG3300	MHYT domain
RGI145_RS11900	COG5001	Diguanylate cyclase
RGI145_RS11930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RGI145_RS11940	COG3706	GGDEF domain
RGI145_RS11940	COG4251	negative regulation of phosphorylation
RGI145_RS11940	COG2203	Gaf domain
RGI145_RS11940	COG5001	Diguanylate cyclase
RGI145_RS11945	COG1473	amidohydrolase
RGI145_RS11950	COG0306	phosphate transporter
RGI145_RS11955	COG1392	Phosphate transport regulator
RGI145_RS12000	COG1840	ABC-type Fe3 transport system, periplasmic component
RGI145_RS12020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RGI145_RS12025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RGI145_RS12030	COG0196	riboflavin kinase activity
RGI145_RS12065	COG0531	amino acid
RGI145_RS12085	COG0215	cysteine-tRNA ligase activity
RGI145_RS12090	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
RGI145_RS12090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RGI145_RS12130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RGI145_RS12140	COG0366	Alpha amylase catalytic
RGI145_RS12150	COG2233	PERMEase
RGI145_RS12155	COG1024	Enoyl-CoA hydratase
RGI145_RS12160	COG0268	Binds directly to 16S ribosomal RNA
RGI145_RS12165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RGI145_RS12175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RGI145_RS12225	COG0745	RESPONSE REGULATOR receiver
RGI145_RS12225	COG4566	intracellular signal transduction
RGI145_RS12230	COG1960	acyl-CoA dehydrogenase activity
RGI145_RS12235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RGI145_RS12240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RGI145_RS12245	COG2271	Major facilitator Superfamily
RGI145_RS12255	COG0583	DNA-binding transcription factor activity
RGI145_RS12270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RGI145_RS12275	COG2362	D-Aminopeptidase
RGI145_RS12310	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RGI145_RS12315	COG1530	ribonuclease E activity
RGI145_RS12320	COG0424	maF-like protein
RGI145_RS12325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RGI145_RS12330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RGI145_RS12340	COG0717	Belongs to the dCTP deaminase family
RGI145_RS12345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RGI145_RS12355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RGI145_RS12510	COG1061	Type III restriction enzyme res subunit
RGI145_RS12565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RGI145_RS12590	COG4974	Belongs to the 'phage' integrase family
RGI145_RS12595	COG5001	Diguanylate cyclase
RGI145_RS12595	COG3300	MHYT domain
RGI145_RS12605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RGI145_RS12610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RGI145_RS12630	COG0653	protein targeting
RGI145_RS12660	COG0671	phosphoesterase, PA-phosphatase related
RGI145_RS12665	COG4974	Belongs to the 'phage' integrase family
RGI145_RS12670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RGI145_RS12690	COG0484	heat shock protein binding
RGI145_RS12715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RGI145_RS12725	COG5265	(ABC) transporter
RGI145_RS12735	COG4221	oxidoreductase activity
RGI145_RS12775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RGI145_RS12785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RGI145_RS12790	COG0756	dUTP diphosphatase activity
RGI145_RS12795	COG0747	negative chemotaxis
RGI145_RS12800	COG2814	Major facilitator Superfamily
RGI145_RS12805	COG2226	methyltransferase
RGI145_RS12810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RGI145_RS12815	COG1335	isochorismatase
RGI145_RS12835	COG0778	Nitroreductase
RGI145_RS12840	COG3180	Ammonia monooxygenase
RGI145_RS12845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RGI145_RS12850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RGI145_RS12860	COG0546	phosphoglycolate phosphatase activity
RGI145_RS12880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RGI145_RS12880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RGI145_RS12910	COG1999	signal sequence binding
RGI145_RS12915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RGI145_RS12925	COG0330	HflC and HflK could
RGI145_RS12935	COG0489	protein tyrosine kinase activity
RGI145_RS12950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
RGI145_RS12970	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RGI145_RS12970	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RGI145_RS12975	COG1063	alcohol dehydrogenase
RGI145_RS12990	COG0114	fumarate hydratase activity
RGI145_RS13035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
RGI145_RS13055	COG0745	RESPONSE REGULATOR receiver
RGI145_RS13080	COG4786	Flagellar basal body rod
RGI145_RS13085	COG4786	Flagellar basal body rod
RGI145_RS13095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RGI145_RS13105	COG2135	peptidase activity
RGI145_RS13110	COG2351	hydroxyisourate hydrolase activity
RGI145_RS13115	COG2072	flavoprotein involved in K transport
RGI145_RS13120	COG5001	Diguanylate cyclase
RGI145_RS13145	COG2321	neutral zinc metallopeptidase
RGI145_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS13180	COG1408	metallophosphoesterase
RGI145_RS13185	COG0596	Alpha beta hydrolase
RGI145_RS13190	COG0604	alcohol dehydrogenase
RGI145_RS13195	COG0683	leucine binding
RGI145_RS13215	COG5328	Belongs to the UPF0262 family
RGI145_RS13220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RGI145_RS13230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RGI145_RS13235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RGI145_RS13250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RGI145_RS13255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RGI145_RS13270	COG2205	protein histidine kinase activity
RGI145_RS13285	COG0436	Aminotransferase
RGI145_RS13290	COG4993	Dehydrogenase
RGI145_RS13300	COG4651	solute:proton antiporter activity
RGI145_RS13300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RGI145_RS13310	COG2308	Evidence 4 Homologs of previously reported genes of
RGI145_RS13340	COG1793	dna ligase
RGI145_RS13350	COG0538	isocitrate dehydrogenase activity
RGI145_RS13355	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS13360	COG0747	negative chemotaxis
RGI145_RS13375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS13400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RGI145_RS13405	COG3023	N-Acetylmuramoyl-L-alanine amidase
RGI145_RS13415	COG2001	Belongs to the MraZ family
RGI145_RS13420	COG0275	rRNA processing
RGI145_RS13435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RGI145_RS13440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RGI145_RS13445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RGI145_RS13450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RGI145_RS13460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RGI145_RS13465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RGI145_RS13470	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RGI145_RS13475	COG1181	Belongs to the D-alanine--D-alanine ligase family
RGI145_RS13480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RGI145_RS13485	COG0849	cell division
RGI145_RS13490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RGI145_RS13500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RGI145_RS13505	COG0497	DNA recombination
RGI145_RS13515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RGI145_RS13520	COG1473	amidohydrolase
RGI145_RS13535	COG0477	Major facilitator Superfamily
RGI145_RS13540	COG1280	lysine exporter protein (LysE YggA)
RGI145_RS13545	COG0659	secondary active sulfate transmembrane transporter activity
RGI145_RS13560	COG2264	protein methyltransferase activity
RGI145_RS13565	COG0210	DNA helicase
RGI145_RS13575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RGI145_RS13585	COG2853	Lipoprotein
RGI145_RS13620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RGI145_RS13625	COG1177	transmembrane transport
RGI145_RS13635	COG3842	ATPase activity
RGI145_RS13655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RGI145_RS13660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RGI145_RS13695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RGI145_RS13700	COG0358	DNA primase activity
RGI145_RS13710	COG1610	YqeY-like protein
RGI145_RS13715	COG0505	Belongs to the CarA family
RGI145_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS13730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RGI145_RS13735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RGI145_RS13740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RGI145_RS13745	COG1522	sequence-specific DNA binding
RGI145_RS13750	COG0492	ferredoxin-NADP+ reductase activity
RGI145_RS13755	COG0583	DNA-binding transcription factor activity
RGI145_RS13765	COG0203	ribosomal protein L17
RGI145_RS13770	COG0202	RNA polymerase activity
RGI145_RS13775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RGI145_RS13780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RGI145_RS13785	COG0563	adenylate kinase activity
RGI145_RS13790	COG0201	protein transport
RGI145_RS13795	COG0200	Binds to the 23S rRNA
RGI145_RS13800	COG1841	ribosomal large subunit assembly
RGI145_RS13805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RGI145_RS13810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RGI145_RS13815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RGI145_RS13820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RGI145_RS13825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RGI145_RS13830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RGI145_RS13835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RGI145_RS13840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RGI145_RS13845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RGI145_RS13850	COG0255	Belongs to the universal ribosomal protein uL29 family
RGI145_RS13855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RGI145_RS13860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RGI145_RS13865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RGI145_RS13870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RGI145_RS13875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RGI145_RS13880	COG0089	rRNA binding
RGI145_RS13885	COG0088	Forms part of the polypeptide exit tunnel
RGI145_RS13890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RGI145_RS13895	COG0051	transcription antitermination factor activity, RNA binding
RGI145_RS13900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RGI145_RS13905	COG0049	tRNA binding
RGI145_RS13910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RGI145_RS13915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RGI145_RS13920	COG0085	RNA polymerase activity
RGI145_RS13925	COG0222	ribosome binding
RGI145_RS13930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RGI145_RS13935	COG0081	regulation of translation
RGI145_RS13940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RGI145_RS13950	COG1132	(ABC) transporter
RGI145_RS13955	COG0438	transferase activity, transferring glycosyl groups
RGI145_RS13960	COG2885	chlorophyll binding
RGI145_RS13960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RGI145_RS13980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RGI145_RS13995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGI145_RS14060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGI145_RS14065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS14075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGI145_RS14080	COG1116	anion transmembrane transporter activity
RGI145_RS14085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGI145_RS14090	COG1522	sequence-specific DNA binding
RGI145_RS14095	COG0784	Response regulator, receiver
RGI145_RS14095	COG2205	protein histidine kinase activity
RGI145_RS14100	COG1914	H( )-stimulated, divalent metal cation uptake system
RGI145_RS14125	COG0789	Transcriptional regulator
RGI145_RS14135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS14140	COG4191	Histidine kinase
RGI145_RS14140	COG0784	Response regulator, receiver
RGI145_RS14145	COG0556	nucleotide-excision repair
RGI145_RS14175	COG0322	excinuclease ABC activity
RGI145_RS14180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RGI145_RS14190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RGI145_RS14195	COG0314	molybdopterin synthase activity
RGI145_RS14210	COG2271	Major facilitator Superfamily
RGI145_RS14215	COG1473	amidohydrolase
RGI145_RS14220	COG0745	RESPONSE REGULATOR receiver
RGI145_RS14225	COG1846	Transcriptional regulator
RGI145_RS14230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RGI145_RS14260	COG0501	Belongs to the peptidase M48B family
RGI145_RS14270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS14275	COG0012	GTP binding
RGI145_RS14295	COG0714	Associated with various cellular activities
RGI145_RS14315	COG0617	tRNA 3'-terminal CCA addition
RGI145_RS14320	COG2259	Doxx family
RGI145_RS14325	COG1132	(ABC) transporter
RGI145_RS14345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RGI145_RS14350	COG1127	ABC transporter
RGI145_RS14355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RGI145_RS14355	COG3008	intermembrane lipid transfer
RGI145_RS14375	COG0573	inorganic phosphate transmembrane transporter activity
RGI145_RS14380	COG0581	inorganic phosphate transmembrane transporter activity
RGI145_RS14385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RGI145_RS14395	COG0745	RESPONSE REGULATOR receiver
RGI145_RS14400	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS14405	COG0747	negative chemotaxis
RGI145_RS14410	COG2814	Major facilitator Superfamily
RGI145_RS14420	COG5001	Diguanylate cyclase
RGI145_RS14420	COG3706	GGDEF domain
RGI145_RS14420	COG2203	Gaf domain
RGI145_RS14420	COG4251	negative regulation of phosphorylation
RGI145_RS14425	COG1742	UPF0060 membrane protein
RGI145_RS14430	COG3181	Tripartite tricarboxylate transporter family receptor
RGI145_RS14435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGI145_RS14440	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RGI145_RS14445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RGI145_RS14450	COG0564	pseudouridine synthase activity
RGI145_RS14455	COG3920	Histidine kinase
RGI145_RS14475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RGI145_RS14480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RGI145_RS14485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RGI145_RS14490	COG0356	it plays a direct role in the translocation of protons across the membrane
RGI145_RS14500	COG1132	(ABC) transporter
RGI145_RS14505	COG1196	nuclear chromosome segregation
RGI145_RS14510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RGI145_RS14525	COG1268	BioY protein
RGI145_RS14530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RGI145_RS14535	COG0318	PFAM AMP-dependent synthetase and ligase
RGI145_RS14550	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RGI145_RS14560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RGI145_RS14570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RGI145_RS14580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RGI145_RS14580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RGI145_RS14585	COG0509	glycine decarboxylation via glycine cleavage system
RGI145_RS14590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RGI145_RS14620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RGI145_RS14625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RGI145_RS14630	COG0328	RNA-DNA hybrid ribonuclease activity
RGI145_RS14640	COG0521	Mo-molybdopterin cofactor biosynthetic process
RGI145_RS14655	COG0583	DNA-binding transcription factor activity
RGI145_RS14660	COG0741	lytic transglycosylase activity
RGI145_RS14665	COG1573	uracil-dna glycosylase
RGI145_RS14680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RGI145_RS14680	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RGI145_RS14680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RGI145_RS14695	COG0747	negative chemotaxis
RGI145_RS14725	COG0678	peroxiredoxin activity
RGI145_RS14730	COG1678	Uncharacterized ACR, COG1678
RGI145_RS14740	COG0747	negative chemotaxis
RGI145_RS14745	COG2721	sulfolactate sulfo-lyase activity
RGI145_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS14785	COG1335	isochorismatase
RGI145_RS14790	COG4221	oxidoreductase activity
RGI145_RS14810	COG0411	ABC transporter
RGI145_RS14820	COG0179	Fumarylacetoacetate (FAA) hydrolase
RGI145_RS14830	COG0346	lactoylglutathione lyase activity
RGI145_RS14840	COG2223	nitrite transmembrane transporter activity
RGI145_RS14845	COG1127	ABC transporter
RGI145_RS14850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RGI145_RS14865	COG0305	Participates in initiation and elongation during chromosome replication
RGI145_RS14875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RGI145_RS14880	COG0359	binds to the 23S rRNA
RGI145_RS14890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RGI145_RS14895	COG0360	Binds together with S18 to 16S ribosomal RNA
RGI145_RS14910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RGI145_RS14930	COG1959	2 iron, 2 sulfur cluster binding
RGI145_RS14935	COG1017	nitric oxide dioxygenase activity
RGI145_RS14935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RGI145_RS14940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS14960	COG0747	negative chemotaxis
RGI145_RS14975	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RGI145_RS14985	COG1987	bacterial-type flagellum assembly
RGI145_RS14990	COG1677	Flagellar hook-basal body complex protein FliE
RGI145_RS14995	COG1558	bacterial-type flagellum-dependent cell motility
RGI145_RS15010	COG1338	Plays a role in the flagellum-specific transport system
RGI145_RS15025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RGI145_RS15030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RGI145_RS15035	COG3237	CsbD-like
RGI145_RS15045	COG4948	Mandelate Racemase Muconate Lactonizing
RGI145_RS15060	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RGI145_RS15065	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RGI145_RS15080	COG0131	Imidazoleglycerol-phosphate dehydratase
RGI145_RS15090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RGI145_RS15100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RGI145_RS15105	COG0546	phosphoglycolate phosphatase activity
RGI145_RS15125	COG3616	Alanine racemase, N-terminal domain
RGI145_RS15130	COG0837	glucose binding
RGI145_RS15135	COG0747	negative chemotaxis
RGI145_RS15140	COG0107	imidazoleglycerol-phosphate synthase activity
RGI145_RS15145	COG0140	phosphoribosyl-ATP diphosphatase activity
RGI145_RS15175	COG1217	gtp-binding protein TYPA
RGI145_RS15200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGI145_RS15210	COG0366	Alpha amylase catalytic
RGI145_RS15230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RGI145_RS15235	COG1640	4-alpha-glucanotransferase
RGI145_RS15255	COG0058	SHG alpha-glucan phosphorylase activity
RGI145_RS15260	COG0297	glycogen (starch) synthase activity
RGI145_RS15280	COG2884	Cell division ATP-binding protein ftsE
RGI145_RS15325	COG0523	cobalamin synthesis protein
RGI145_RS15365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS15385	COG4221	oxidoreductase activity
RGI145_RS15405	COG0673	inositol 2-dehydrogenase activity
RGI145_RS15415	COG0395	ABC-type sugar transport system, permease component
RGI145_RS15420	COG1175	transmembrane transport
RGI145_RS15425	COG1309	transcriptional regulator
RGI145_RS15430	COG0673	inositol 2-dehydrogenase activity
RGI145_RS15450	COG4774	siderophore transport
RGI145_RS15455	COG1595	DNA-templated transcription, initiation
RGI145_RS15465	COG4774	siderophore transport
RGI145_RS15540	COG3181	Tripartite tricarboxylate transporter family receptor
RGI145_RS15550	COG1177	transmembrane transport
RGI145_RS15555	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGI145_RS15565	COG3485	protocatechuate 3,4-dioxygenase
RGI145_RS15570	COG3485	protocatechuate 3,4-dioxygenase
RGI145_RS15575	COG0583	DNA-binding transcription factor activity
RGI145_RS15590	COG0583	DNA-binding transcription factor activity
RGI145_RS15600	COG0432	Pfam Uncharacterised protein family UPF0047
RGI145_RS15615	COG1473	amidohydrolase
RGI145_RS15620	COG0471	metal ion transport
RGI145_RS15625	COG0039	L-malate dehydrogenase activity
RGI145_RS15630	COG0747	negative chemotaxis
RGI145_RS15635	COG3047	cAMP biosynthetic process
RGI145_RS15640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGI145_RS15650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGI145_RS15660	COG1294	oxidase, subunit
RGI145_RS15670	COG4988	ABC transporter
RGI145_RS15675	COG1132	(ABC) transporter
RGI145_RS15680	COG4774	siderophore transport
RGI145_RS15695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RGI145_RS15700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS15705	COG0747	negative chemotaxis
RGI145_RS15715	COG0242	peptide deformylase activity
RGI145_RS15725	COG2186	Transcriptional regulator
RGI145_RS15745	COG3052	prosthetic group binding
RGI145_RS15765	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
RGI145_RS15790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS15795	COG0601	transmembrane transport
RGI145_RS15800	COG0747	negative chemotaxis
RGI145_RS15805	COG1312	Catalyzes the dehydration of D-mannonate
RGI145_RS15810	COG4948	Mandelate Racemase Muconate Lactonizing
RGI145_RS15840	COG0028	Belongs to the TPP enzyme family
RGI145_RS15845	COG4952	isomerase
RGI145_RS15850	COG3347	Dehydrogenase
RGI145_RS15850	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS15860	COG3254	rhamnose metabolic process
RGI145_RS15885	COG2814	Major facilitator Superfamily
RGI145_RS15890	COG1053	succinate dehydrogenase
RGI145_RS15895	COG1902	pentaerythritol trinitrate reductase activity
RGI145_RS15905	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS15975	COG0583	DNA-binding transcription factor activity
RGI145_RS15990	COG2205	protein histidine kinase activity
RGI145_RS15995	COG0745	RESPONSE REGULATOR receiver
RGI145_RS16000	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RGI145_RS16005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGI145_RS16050	COG0803	Belongs to the bacterial solute-binding protein 9 family
RGI145_RS16055	COG0477	Major facilitator Superfamily
RGI145_RS16060	COG0747	negative chemotaxis
RGI145_RS16065	COG0601	transmembrane transport
RGI145_RS16070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS16085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS16090	COG0508	dehydrogenase complex catalyzes the overall conversion of
RGI145_RS16105	COG0045	succinate-CoA ligase (ADP-forming) activity
RGI145_RS16110	COG0039	L-malate dehydrogenase activity
RGI145_RS16120	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RGI145_RS16125	COG3964	amidohydrolase
RGI145_RS16130	COG1971	Probably functions as a manganese efflux pump
RGI145_RS16135	COG0673	inositol 2-dehydrogenase activity
RGI145_RS16140	COG0166	Belongs to the GPI family
RGI145_RS16150	COG0612	Peptidase, M16
RGI145_RS16155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RGI145_RS16165	COG2009	succinate dehydrogenase
RGI145_RS16170	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RGI145_RS16195	COG1672	PFAM Archaeal ATPase
RGI145_RS16195	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RGI145_RS16220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGI145_RS16230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RGI145_RS16235	COG0830	nickel cation binding
RGI145_RS16240	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RGI145_RS16245	COG0804	urea catabolic process
RGI145_RS16250	COG0832	Belongs to the urease beta subunit family
RGI145_RS16255	COG0831	urea catabolic process
RGI145_RS16265	COG0829	nickel cation binding
RGI145_RS16275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RGI145_RS16285	COG0747	negative chemotaxis
RGI145_RS16295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RGI145_RS16300	COG0747	negative chemotaxis
RGI145_RS16315	COG5001	Diguanylate cyclase
RGI145_RS16325	COG2985	domain, Protein
RGI145_RS16330	COG1420	regulation of RNA biosynthetic process
RGI145_RS16335	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS16345	COG0179	Fumarylacetoacetate (FAA) hydrolase
RGI145_RS16350	COG1802	Transcriptional regulator
RGI145_RS16355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RGI145_RS16360	COG0129	dihydroxy-acid dehydratase activity
RGI145_RS16365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGI145_RS16370	COG2205	protein histidine kinase activity
RGI145_RS16380	COG0745	RESPONSE REGULATOR receiver
RGI145_RS16405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RGI145_RS16415	COG0129	dihydroxy-acid dehydratase activity
RGI145_RS16420	COG4303	Ethanolamine ammonia lyase large subunit
RGI145_RS16425	COG4302	ethanolamine ammonia-lyase activity
RGI145_RS16440	COG0235	Class ii aldolase
RGI145_RS16460	COG1960	acyl-CoA dehydrogenase activity
RGI145_RS16465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RGI145_RS16485	COG0318	PFAM AMP-dependent synthetase and ligase
RGI145_RS16520	COG2814	Major facilitator Superfamily
RGI145_RS16525	COG1335	isochorismatase
RGI145_RS16530	COG0281	malic enzyme
RGI145_RS16530	COG0280	phosphate acetyltransferase
RGI145_RS16535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RGI145_RS16545	COG0165	Argininosuccinate lyase
RGI145_RS16550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RGI145_RS16570	COG0028	Belongs to the TPP enzyme family
RGI145_RS16590	COG0019	diaminopimelate decarboxylase activity
RGI145_RS16595	COG1196	nuclear chromosome segregation
RGI145_RS16595	COG0741	lytic transglycosylase activity
RGI145_RS16595	COG0739	heme binding
RGI145_RS16605	COG2223	nitrite transmembrane transporter activity
RGI145_RS16610	COG2267	carboxylic ester hydrolase activity
RGI145_RS16615	COG0251	oxidation-reduction process
RGI145_RS16620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RGI145_RS16620	COG0475	glutathione-regulated potassium exporter activity
RGI145_RS16630	COG1136	(ABC) transporter
RGI145_RS16665	COG2271	Major facilitator Superfamily
RGI145_RS16680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGI145_RS16685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGI145_RS16710	COG0583	DNA-binding transcription factor activity
RGI145_RS16720	COG2271	Major facilitator Superfamily
RGI145_RS16745	COG0747	negative chemotaxis
RGI145_RS16775	COG1566	PFAM secretion protein HlyD family protein
RGI145_RS16790	COG2771	luxR family
RGI145_RS16825	COG2943	transferase activity, transferring hexosyl groups
RGI145_RS16830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RGI145_RS16835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RGI145_RS16840	COG2706	6-phosphogluconolactonase activity
RGI145_RS16860	COG2159	amidohydrolase
RGI145_RS16865	COG3618	amidohydrolase
RGI145_RS16870	COG1620	l-lactate permease
RGI145_RS16875	COG2186	Transcriptional regulator
RGI145_RS16880	COG1304	FMN binding
RGI145_RS16905	COG1301	dicarboxylic acid transport
RGI145_RS16910	COG1454	alcohol dehydrogenase
RGI145_RS16915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGI145_RS16920	COG1454	alcohol dehydrogenase
RGI145_RS16925	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
RGI145_RS16930	COG2375	cellular response to nickel ion
RGI145_RS16940	COG1570	exodeoxyribonuclease VII activity
RGI145_RS16945	COG0739	heme binding
RGI145_RS16955	COG3119	arylsulfatase activity
RGI145_RS16965	COG2072	flavoprotein involved in K transport
RGI145_RS16970	COG0747	negative chemotaxis
RGI145_RS16995	COG4774	siderophore transport
RGI145_RS17015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RGI145_RS17025	COG2079	MmgE PrpD family protein
RGI145_RS17030	COG1473	amidohydrolase
RGI145_RS17035	COG0180	Tryptophanyl-tRNA synthetase
RGI145_RS17040	COG0728	peptidoglycan biosynthetic process
RGI145_RS17045	COG2814	Major facilitator Superfamily
RGI145_RS17065	COG1295	ribonuclease BN
RGI145_RS17070	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
RGI145_RS17140	COG2201	protein-glutamate methylesterase activity
RGI145_RS17155	COG2186	Transcriptional regulator
RGI145_RS17165	COG0402	S-adenosylhomocysteine deaminase activity
RGI145_RS17170	COG1228	amidohydrolase
RGI145_RS17175	COG0583	DNA-binding transcription factor activity
RGI145_RS17180	COG1522	sequence-specific DNA binding
RGI145_RS17200	COG0252	asparaginase activity
RGI145_RS17205	COG1335	isochorismatase
RGI145_RS17210	COG1335	isochorismatase
RGI145_RS17215	COG0444	Belongs to the ABC transporter superfamily
RGI145_RS17220	COG4608	Belongs to the ABC transporter superfamily
RGI145_RS17225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS17235	COG0747	negative chemotaxis
RGI145_RS17245	COG0154	amidase activity
RGI145_RS17250	COG0154	amidase activity
RGI145_RS17260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RGI145_RS17270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RGI145_RS17280	COG3639	organic phosphonate transmembrane transporter activity
RGI145_RS17290	COG2188	Transcriptional regulator
RGI145_RS17295	COG3624	Phosphonate C-P lyase system protein PhnG
RGI145_RS17300	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RGI145_RS17305	COG3626	phosphonate metabolism
RGI145_RS17310	COG3627	carbon phosphorus lyase activity
RGI145_RS17315	COG4107	phosphonate C-P lyase system protein PhnK
RGI145_RS17320	COG4778	phosphonate C-P lyase system protein PhnL
RGI145_RS17325	COG3454	Phosphonate metabolism
RGI145_RS17330	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RGI145_RS17340	COG1522	sequence-specific DNA binding
RGI145_RS17345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RGI145_RS17350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS17365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGI145_RS17390	COG0747	negative chemotaxis
RGI145_RS17400	COG4608	Belongs to the ABC transporter superfamily
RGI145_RS17410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS17425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RGI145_RS17435	COG0747	negative chemotaxis
RGI145_RS17440	COG4191	Histidine kinase
RGI145_RS17440	COG0784	Response regulator, receiver
RGI145_RS17455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RGI145_RS17465	COG0601	transmembrane transport
RGI145_RS17470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS17475	COG0444	Belongs to the ABC transporter superfamily
RGI145_RS17485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGI145_RS17490	COG1349	DNA-binding transcription factor activity
RGI145_RS17500	COG4149	molybdate abc transporter
RGI145_RS17505	COG0725	ABC transporter, periplasmic molybdate-binding protein
RGI145_RS17510	COG0779	Required for maturation of 30S ribosomal subunits
RGI145_RS17525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RGI145_RS17530	COG5373	membrane
RGI145_RS17530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RGI145_RS17535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RGI145_RS17540	COG1607	acyl-coa hydrolase
RGI145_RS17555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RGI145_RS17560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RGI145_RS17580	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RGI145_RS17585	COG0583	DNA-binding transcription factor activity
RGI145_RS17590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS17595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGI145_RS17605	COG1126	abc transporter atp-binding protein
RGI145_RS17610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RGI145_RS17635	COG0765	amino acid transport
RGI145_RS17660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RGI145_RS17670	COG2079	MmgE PrpD family protein
RGI145_RS17675	COG1396	sequence-specific DNA binding
RGI145_RS17675	COG3800	Transcriptional regulator
RGI145_RS17680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RGI145_RS17690	COG0656	L-ascorbic acid biosynthetic process
RGI145_RS17700	COG1414	Transcriptional regulator
RGI145_RS17715	COG4214	carbohydrate transport
RGI145_RS17720	COG1129	ABC transporter
RGI145_RS17725	COG4213	ABC transporter substrate-binding protein
RGI145_RS17740	COG0129	dihydroxy-acid dehydratase activity
RGI145_RS17750	COG2375	cellular response to nickel ion
RGI145_RS17760	COG0481	GTPase activity
RGI145_RS17775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RGI145_RS17780	COG0181	hydroxymethylbilane synthase activity
RGI145_RS17785	COG0753	catalase activity
RGI145_RS17805	COG0649	NAD binding
RGI145_RS17805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGI145_RS17810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGI145_RS17815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RGI145_RS17825	COG1396	sequence-specific DNA binding
RGI145_RS17830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RGI145_RS17840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RGI145_RS17845	COG1702	phosphate starvation-inducible protein PhoH
RGI145_RS17850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RGI145_RS17870	COG3483	tryptophan 2,3-dioxygenase activity
RGI145_RS17875	COG2140	Oxalate decarboxylase
RGI145_RS17885	COG1845	cytochrome c oxidase, subunit III
RGI145_RS17930	COG0437	4 iron, 4 sulfur cluster binding
RGI145_RS17960	COG0484	heat shock protein binding
RGI145_RS17965	COG0443	Heat shock 70 kDa protein
RGI145_RS17975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RGI145_RS17985	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RGI145_RS18020	COG1546	Belongs to the CinA family
RGI145_RS18020	COG1058	Belongs to the CinA family
RGI145_RS18030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RGI145_RS18035	COG0326	Molecular chaperone. Has ATPase activity
RGI145_RS18075	COG1178	ABC-type Fe3 transport system permease component
RGI145_RS18095	COG3842	ATPase activity
RGI145_RS18100	COG2217	Heavy metal translocating P-type atpase
RGI145_RS18110	COG2608	mercury ion transmembrane transporter activity
RGI145_RS18115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RGI145_RS18120	COG0552	protein localization to endoplasmic reticulum
RGI145_RS18155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RGI145_RS18160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RGI145_RS18165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RGI145_RS18170	COG0072	phenylalanine-tRNA ligase activity
RGI145_RS18170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGI145_RS18175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RGI145_RS18175	COG0551	DNA topoisomerase type I activity
RGI145_RS18180	COG4957	zinc ion binding
RGI145_RS18195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RGI145_RS18210	COG2367	Beta-lactamase
RGI145_RS18215	COG0154	amidase activity
RGI145_RS18220	COG0747	negative chemotaxis
RGI145_RS18255	COG0741	lytic transglycosylase activity
RGI145_RS18290	COG2223	nitrite transmembrane transporter activity
RGI145_RS18305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RGI145_RS18305	COG0546	phosphoglycolate phosphatase activity
RGI145_RS18330	COG0784	Response regulator, receiver
RGI145_RS18330	COG5002	protein histidine kinase activity
RGI145_RS18330	COG2205	protein histidine kinase activity
RGI145_RS18340	COG0400	carboxylic ester hydrolase activity
RGI145_RS18345	COG0346	lactoylglutathione lyase activity
RGI145_RS18350	COG0583	DNA-binding transcription factor activity
RGI145_RS18355	COG1309	transcriptional regulator
RGI145_RS18360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RGI145_RS18360	COG2111	Na H antiporter
RGI145_RS18365	COG1006	Multisubunit Na H antiporter MnhC subunit
RGI145_RS18370	COG0651	ATP synthesis coupled electron transport
RGI145_RS18385	COG1320	monovalent cation:proton antiporter activity
RGI145_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS18415	COG1053	succinate dehydrogenase
RGI145_RS18430	COG0010	Belongs to the arginase family
RGI145_RS18440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RGI145_RS18460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RGI145_RS18465	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RGI145_RS18470	COG2080	2 iron, 2 sulfur cluster binding
RGI145_RS18475	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RGI145_RS18500	COG0154	amidase activity
RGI145_RS18525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RGI145_RS18530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RGI145_RS18540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RGI145_RS18545	COG1331	Highly conserved protein containing a thioredoxin domain
RGI145_RS18550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RGI145_RS18565	COG0747	negative chemotaxis
RGI145_RS18570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGI145_RS18575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGI145_RS18580	COG0737	Belongs to the 5'-nucleotidase family
RGI145_RS18585	COG0730	response to heat
RGI145_RS18595	COG0445	tRNA wobble uridine modification
RGI145_RS18600	COG0357	Ribosomal RNA small subunit methyltransferase G
RGI145_RS18630	COG0495	leucyl-tRNA aminoacylation
RGI145_RS18635	COG5001	Diguanylate cyclase
RGI145_RS18635	COG3300	MHYT domain
RGI145_RS18645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RGI145_RS18650	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RGI145_RS18670	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS18675	COG0183	Belongs to the thiolase family
RGI145_RS18680	COG2226	methyltransferase
RGI145_RS18700	COG1950	PFAM Membrane protein of
RGI145_RS18725	COG2264	protein methyltransferase activity
RGI145_RS18735	COG0424	maF-like protein
RGI145_RS18740	COG1283	sodium-dependent phosphate transmembrane transporter activity
RGI145_RS18750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RGI145_RS18755	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RGI145_RS18760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RGI145_RS18770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGI145_RS18790	COG0672	)-iron permease
RGI145_RS18835	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RGI145_RS18840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RGI145_RS18860	COG0442	prolyl-tRNA aminoacylation
RGI145_RS18865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGI145_RS18875	COG4235	cytochrome complex assembly
RGI145_RS18880	COG3088	subunit of a heme lyase
RGI145_RS18885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RGI145_RS18890	COG1138	Cytochrome C-type biogenesis protein
RGI145_RS18895	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RGI145_RS18900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RGI145_RS18920	COG1879	ABC-type sugar transport system periplasmic component
RGI145_RS18925	COG1172	Belongs to the binding-protein-dependent transport system permease family
RGI145_RS18940	COG4172	Belongs to the ABC transporter superfamily
RGI145_RS18945	COG0747	negative chemotaxis
RGI145_RS18950	COG0601	transmembrane transport
RGI145_RS18955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGI145_RS18965	COG1132	(ABC) transporter
RGI145_RS18975	COG0716	FMN binding
RGI145_RS18990	COG1012	belongs to the aldehyde dehydrogenase family
RGI145_RS19000	COG0028	Belongs to the TPP enzyme family
RGI145_RS19015	COG1414	Transcriptional regulator
RGI145_RS19025	COG1028	Short-chain dehydrogenase reductase Sdr
RGI145_RS19035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGI145_RS19060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RGI145_RS19075	COG2011	ABC-type metal ion transport system permease component
RGI145_RS19080	COG1464	Belongs to the NlpA lipoprotein family
RGI145_RS19085	COG1464	Belongs to the NlpA lipoprotein family
RGI145_RS19090	COG1464	Belongs to the NlpA lipoprotein family
RGI145_RS19095	COG5508	conserved small protein
RGI145_RS19100	COG0501	Belongs to the peptidase M48B family
RGI145_RS19105	COG4166	transmembrane transport
RGI145_RS19110	COG0601	transmembrane transport
RGI145_RS19115	COG0444	Belongs to the ABC transporter superfamily
RGI145_RS19140	COG1012	belongs to the aldehyde dehydrogenase family
RGI145_RS19155	COG1696	Membrane protein involved in D-alanine export
RGI145_RS19185	COG4957	zinc ion binding
RGI145_RS19195	COG0159	tryptophan synthase activity
RGI145_RS19200	COG0133	tryptophan synthase activity
RGI145_RS19210	COG0463	Glycosyl transferase, family 2
RGI145_RS19215	COG1612	heme a metabolic process
RGI145_RS19220	COG2205	protein histidine kinase activity
RGI145_RS19220	COG2202	Pas domain
RGI145_RS19225	COG0312	modulator of DNA gyrase
RGI145_RS19230	COG0243	molybdopterin cofactor binding
RGI145_RS19250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RGI145_RS19255	COG0285	dihydrofolate synthase activity
RGI145_RS19270	COG0640	Transcriptional regulator
RGI145_RS19275	COG1565	acr, cog1565
RGI145_RS19275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RGI145_RS19280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RGI145_RS19285	COG0109	protoheme IX farnesyltransferase activity
RGI145_RS19330	COG1663	tetraacyldisaccharide 4'-kinase activity
RGI145_RS19335	COG1519	Transferase
RGI145_RS19340	COG2121	Domain of unknown function (DUF374)
RGI145_RS19355	COG1505	serine-type exopeptidase activity
RGI145_RS19360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RGI145_RS19365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RGI145_RS19370	COG0523	cobalamin synthesis protein
RGI145_RS19390	COG3246	L-lysine catabolic process to acetate
RGI145_RS19400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RGI145_RS19415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RGI145_RS19420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RGI145_RS19425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RGI145_RS19440	COG1473	amidohydrolase
RGI145_RS19445	COG0747	negative chemotaxis
RGI145_RS19485	COG0539	negative regulation of cytoplasmic translation
RGI145_RS19490	COG1335	isochorismatase
RGI145_RS19495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RGI145_RS19500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RGI145_RS19520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGI145_RS19525	COG0742	ribosomal rna small subunit methyltransferase
RGI145_RS19570	COG1523	belongs to the glycosyl hydrolase 13 family
RGI145_RS19610	COG2326	polyphosphate kinase activity
RGI145_RS19650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RGI145_RS19920	COG3842	ATPase activity
RGI145_RS20470	COG3842	ATPase activity
RGI145_RS20525	COG0318	PFAM AMP-dependent synthetase and ligase
RGI145_RS20615	COG0583	DNA-binding transcription factor activity
RGI145_RS20640	COG4774	siderophore transport
RGI145_RS20885	COG2198	Histidine kinase
RGI145_RS20885	COG0784	Response regulator, receiver
RGI145_RS20885	COG2205	protein histidine kinase activity
RGI145_RS21065	COG4174	ABC transporter (Permease)
RGI145_RS21130	COG0765	amino acid transport
RGI145_RS21325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RGI145_RS21605	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RGI145_RS22210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RGI145_RS23160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RGI145_RS23405	COG0745	RESPONSE REGULATOR receiver
RGI145_RS23590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RGI145_RS23940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RGI145_RS24030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RGI145_RS24380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RGI145_RS24475	COG0438	transferase activity, transferring glycosyl groups