locus-tag	class	description
JR346_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JR346_RS00010	COG0592	DNA-directed DNA polymerase activity
JR346_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JR346_RS00025	COG0187	DNA topoisomerase II activity
JR346_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JR346_RS00055	COG1129	ABC transporter
JR346_RS00070	COG0577	efflux transmembrane transporter activity
JR346_RS00070	COG1136	(ABC) transporter
JR346_RS00075	COG0577	efflux transmembrane transporter activity
JR346_RS00075	COG1136	(ABC) transporter
JR346_RS00115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JR346_RS00130	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
JR346_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JR346_RS00140	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JR346_RS00155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JR346_RS00205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JR346_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR346_RS00240	COG3265	gluconokinase activity
JR346_RS00245	COG2610	gluconate transmembrane transporter activity
JR346_RS00275	COG0463	Glycosyl transferase, family 2
JR346_RS00305	COG0477	Major facilitator Superfamily
JR346_RS00320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JR346_RS00325	COG2902	Dehydrogenase
JR346_RS00380	COG1061	Type III restriction enzyme res subunit
JR346_RS00400	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JR346_RS00405	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JR346_RS00410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR346_RS00455	COG1937	Protein conserved in bacteria
JR346_RS00460	COG3387	PFAM Glycoside hydrolase 15-related
JR346_RS00470	COG1595	DNA-templated transcription, initiation
JR346_RS00490	COG3842	ATPase activity
JR346_RS00495	COG0501	Belongs to the peptidase M48B family
JR346_RS00505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JR346_RS00510	COG0280	phosphate acetyltransferase
JR346_RS00510	COG0857	belongs to the CobB CobQ family
JR346_RS00515	COG2132	Multicopper oxidase
JR346_RS00535	COG3012	SEC-C Motif Domain Protein
JR346_RS00545	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
JR346_RS00560	COG2197	response regulator
JR346_RS00565	COG2252	PERMEase
JR346_RS00580	COG0277	FAD linked oxidase domain protein
JR346_RS00610	COG3655	Transcriptional regulator
JR346_RS00625	COG1024	Enoyl-CoA hydratase
JR346_RS00630	COG1024	Enoyl-CoA hydratase
JR346_RS00640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JR346_RS00670	COG0561	phosphatase activity
JR346_RS00680	COG2233	PERMEase
JR346_RS00685	COG2111	Na H antiporter
JR346_RS00685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JR346_RS00690	COG1006	Multisubunit Na H antiporter MnhC subunit
JR346_RS00695	COG0651	ATP synthesis coupled electron transport
JR346_RS00705	COG2212	antiporter activity
JR346_RS00710	COG1320	monovalent cation:proton antiporter activity
JR346_RS00715	COG3104	oligopeptide transport
JR346_RS00730	COG0512	Glutamine amidotransferase of anthranilate synthase
JR346_RS00730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JR346_RS00735	COG1136	(ABC) transporter
JR346_RS00760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JR346_RS00765	COG0357	Ribosomal RNA small subunit methyltransferase G
JR346_RS00765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JR346_RS00840	COG0471	metal ion transport
JR346_RS00845	COG0191	fructose-bisphosphate aldolase activity
JR346_RS00855	COG0686	Belongs to the AlaDH PNT family
JR346_RS00885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JR346_RS00890	COG0069	glutamate synthase activity
JR346_RS00900	COG1121	(ABC) transporter
JR346_RS00905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR346_RS00965	COG2027	D-alanyl-D-alanine carboxypeptidase
JR346_RS00975	COG0037	tRNA processing
JR346_RS00985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JR346_RS00990	COG0302	gtp cyclohydrolase
JR346_RS01000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JR346_RS01005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JR346_RS01030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JR346_RS01035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JR346_RS01070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JR346_RS01095	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JR346_RS01100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JR346_RS01105	COG4129	membrane
JR346_RS01125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JR346_RS01180	COG0739	heme binding
JR346_RS01180	COG0741	lytic transglycosylase activity
JR346_RS01180	COG1196	nuclear chromosome segregation
JR346_RS01240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JR346_RS01275	COG1404	Belongs to the peptidase S8 family
JR346_RS01290	COG0629	single-stranded DNA binding
JR346_RS01300	COG1192	Involved in chromosome partitioning
JR346_RS01370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JR346_RS01390	COG0252	asparaginase activity
JR346_RS01405	COG0477	Major facilitator Superfamily
JR346_RS01410	COG0514	ATP-dependent DNA helicase (RecQ)
JR346_RS01415	COG0590	tRNA wobble adenosine to inosine editing
JR346_RS01430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JR346_RS01435	COG0745	RESPONSE REGULATOR receiver
JR346_RS01440	COG0596	Alpha beta hydrolase
JR346_RS01445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JR346_RS01470	COG2390	Transcriptional regulator
JR346_RS01475	COG1063	alcohol dehydrogenase
JR346_RS01480	COG2376	Dihydroxyacetone kinase
JR346_RS01485	COG0698	ribose 5-phosphate isomerase
JR346_RS01490	COG0246	Mannitol dehydrogenase
JR346_RS01495	COG1070	Carbohydrate kinase
JR346_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
JR346_RS01505	COG1070	Carbohydrate kinase
JR346_RS01520	COG0604	alcohol dehydrogenase
JR346_RS01525	COG1966	Carbon starvation protein
JR346_RS01540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JR346_RS01540	COG2755	lipolytic protein G-D-S-L family
JR346_RS01545	COG2197	response regulator
JR346_RS01550	COG4585	Histidine kinase
JR346_RS01560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JR346_RS01595	COG1254	Belongs to the acylphosphatase family
JR346_RS01625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JR346_RS01640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JR346_RS01650	COG0022	dehydrogenase e1 component
JR346_RS01655	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR346_RS01670	COG2197	response regulator
JR346_RS01680	COG0110	maltose O-acetyltransferase activity
JR346_RS01690	COG0318	PFAM AMP-dependent synthetase and ligase
JR346_RS01695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JR346_RS01700	COG2188	Transcriptional regulator
JR346_RS01720	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JR346_RS01725	COG1940	carbohydrate kinase activity
JR346_RS01730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JR346_RS01735	COG4608	Belongs to the ABC transporter superfamily
JR346_RS01740	COG0444	Belongs to the ABC transporter superfamily
JR346_RS01745	COG0601	transmembrane transport
JR346_RS01750	COG4166	transmembrane transport
JR346_RS01760	COG1464	Belongs to the NlpA lipoprotein family
JR346_RS01765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JR346_RS01770	COG2011	ABC-type metal ion transport system permease component
JR346_RS01780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JR346_RS01785	COG0406	alpha-ribazole phosphatase activity
JR346_RS01790	COG0588	phosphoglycerate mutase activity
JR346_RS01800	COG1349	DNA-binding transcription factor activity
JR346_RS01810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR346_RS01810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR346_RS01815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JR346_RS01840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JR346_RS01855	COG0459	protein refolding
JR346_RS01865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JR346_RS01870	COG1169	isochorismate synthase
JR346_RS01880	COG0328	RNA-DNA hybrid ribonuclease activity
JR346_RS01890	COG2205	protein histidine kinase activity
JR346_RS01895	COG0745	RESPONSE REGULATOR receiver
JR346_RS01920	COG3883	PFAM NLP P60 protein
JR346_RS01920	COG0791	NLP P60 protein
JR346_RS01955	COG0045	succinate-CoA ligase (ADP-forming) activity
JR346_RS01975	COG0783	Belongs to the Dps family
JR346_RS01995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JR346_RS02005	COG1136	(ABC) transporter
JR346_RS02020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JR346_RS02050	COG2409	Drug exporters of the RND superfamily
JR346_RS02060	COG0151	Belongs to the GarS family
JR346_RS02065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JR346_RS02070	COG2188	Transcriptional regulator
JR346_RS02075	COG1620	l-lactate permease
JR346_RS02080	COG0247	lactate metabolic process
JR346_RS02090	COG1556	Lactate utilization protein
JR346_RS02105	COG2409	Drug exporters of the RND superfamily
JR346_RS02110	COG0798	PFAM Bile acid sodium symporter
JR346_RS02120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JR346_RS02135	COG1132	(ABC) transporter
JR346_RS02140	COG1132	(ABC) transporter
JR346_RS02150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR346_RS02175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR346_RS02180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JR346_RS02185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JR346_RS02190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JR346_RS02195	COG0494	nUDIX hydrolase
JR346_RS02240	COG1205	dead DEAH box helicase
JR346_RS02240	COG1111	helicase
JR346_RS02255	COG1054	Belongs to the UPF0176 family
JR346_RS02275	COG1754	DNA topoisomerase type I activity
JR346_RS02275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JR346_RS02280	COG1082	Xylose isomerase domain protein TIM barrel
JR346_RS02285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR346_RS02290	COG0569	domain protein
JR346_RS02295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JR346_RS02300	COG0123	including yeast histone deacetylase and acetoin utilization protein
JR346_RS02305	COG0640	Transcriptional regulator
JR346_RS02325	COG0406	alpha-ribazole phosphatase activity
JR346_RS02330	COG3118	belongs to the thioredoxin family
JR346_RS02335	COG0785	Cytochrome C biogenesis protein
JR346_RS02345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JR346_RS02385	COG5646	InterPro IPR014922
JR346_RS02410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JR346_RS02415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JR346_RS02420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR346_RS02430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JR346_RS02445	COG4948	Mandelate Racemase Muconate Lactonizing
JR346_RS02455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JR346_RS02470	COG0765	amino acid transport
JR346_RS02475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR346_RS02480	COG2226	methyltransferase
JR346_RS02485	COG0142	geranyltranstransferase activity
JR346_RS02490	COG0733	neurotransmitter:sodium symporter activity
JR346_RS02515	COG2409	Drug exporters of the RND superfamily
JR346_RS02535	COG0501	Belongs to the peptidase M48B family
JR346_RS02540	COG1666	GTP binding
JR346_RS02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR346_RS02585	COG2030	dehydratase
JR346_RS02595	COG0738	Major facilitator superfamily
JR346_RS02600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JR346_RS02610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JR346_RS02615	COG1396	sequence-specific DNA binding
JR346_RS02630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JR346_RS02635	COG2755	lipolytic protein G-D-S-L family
JR346_RS02635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JR346_RS02640	COG0406	alpha-ribazole phosphatase activity
JR346_RS02640	COG0494	nUDIX hydrolase
JR346_RS02645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JR346_RS02650	COG0456	acetyltransferase
JR346_RS02655	COG0745	RESPONSE REGULATOR receiver
JR346_RS02665	COG3485	protocatechuate 3,4-dioxygenase
JR346_RS02680	COG0436	Aminotransferase
JR346_RS02700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JR346_RS02705	COG0081	regulation of translation
JR346_RS02710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JR346_RS02715	COG0222	ribosome binding
JR346_RS02720	COG1621	beta-fructofuranosidase activity
JR346_RS02725	COG2190	(PTS) system
JR346_RS02725	COG1263	PTS System
JR346_RS02725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR346_RS02740	COG0303	'Molybdopterin
JR346_RS02745	COG0746	molybdenum cofactor guanylyltransferase activity
JR346_RS02775	COG0315	cyclic pyranopterin monophosphate synthase activity
JR346_RS02800	COG1140	nitrate reductase beta subunit
JR346_RS02805	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
JR346_RS02820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JR346_RS02820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JR346_RS02825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JR346_RS02830	COG1760	l-serine dehydratase
JR346_RS02835	COG0085	RNA polymerase activity
JR346_RS02840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JR346_RS02850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JR346_RS02855	COG0049	tRNA binding
JR346_RS02860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JR346_RS02865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JR346_RS02870	COG1114	Component of the transport system for branched-chain amino acids
JR346_RS02885	COG0051	transcription antitermination factor activity, RNA binding
JR346_RS02890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JR346_RS02895	COG0088	Forms part of the polypeptide exit tunnel
JR346_RS02900	COG0089	rRNA binding
JR346_RS02905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JR346_RS02910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JR346_RS02915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JR346_RS02920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JR346_RS02925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JR346_RS02935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JR346_RS02940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JR346_RS02945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JR346_RS02950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JR346_RS02955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JR346_RS02960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JR346_RS02970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JR346_RS02975	COG1841	ribosomal large subunit assembly
JR346_RS02980	COG0200	Binds to the 23S rRNA
JR346_RS02990	COG0563	adenylate kinase activity
JR346_RS02995	COG0024	Methionine aminopeptidase
JR346_RS03000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JR346_RS03005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JR346_RS03010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JR346_RS03015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JR346_RS03020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JR346_RS03025	COG0202	RNA polymerase activity
JR346_RS03030	COG0203	ribosomal protein L17
JR346_RS03035	COG0101	tRNA pseudouridine synthase activity
JR346_RS03040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JR346_RS03045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JR346_RS03050	COG2326	polyphosphate kinase activity
JR346_RS03055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JR346_RS03060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR346_RS03060	COG2213	PTS system mannitol-specific
JR346_RS03065	COG0246	Mannitol dehydrogenase
JR346_RS03070	COG1970	mechanosensitive ion channel activity
JR346_RS03075	COG1072	(Pantothenic acid kinase))
JR346_RS03085	COG0736	holo-[acyl-carrier-protein] synthase activity
JR346_RS03105	COG0438	transferase activity, transferring glycosyl groups
JR346_RS03110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JR346_RS03115	COG0802	atpase or kinase
JR346_RS03125	COG0456	acetyltransferase
JR346_RS03130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JR346_RS03135	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JR346_RS03145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JR346_RS03150	COG0459	protein refolding
JR346_RS03155	COG2755	lipolytic protein G-D-S-L family
JR346_RS03155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JR346_RS03165	COG0516	GMP reductase activity
JR346_RS03180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JR346_RS03180	COG0519	Catalyzes the synthesis of GMP from XMP
JR346_RS03185	COG0366	Alpha amylase catalytic
JR346_RS03190	COG0366	Alpha amylase catalytic
JR346_RS03200	COG1263	PTS System
JR346_RS03200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR346_RS03230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JR346_RS03235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JR346_RS03255	COG0668	transmembrane transport
JR346_RS03260	COG0494	nUDIX hydrolase
JR346_RS03275	COG1722	exodeoxyribonuclease VII activity
JR346_RS03280	COG1570	exodeoxyribonuclease VII activity
JR346_RS03290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JR346_RS03295	COG0814	amino acid
JR346_RS03305	COG2197	response regulator
JR346_RS03310	COG4585	Histidine kinase
JR346_RS03320	COG1131	(ABC) transporter
JR346_RS03325	COG0012	GTP binding
JR346_RS03345	COG2824	Alkylphosphonate utilization operon protein PhnA
JR346_RS03355	COG4667	esterase of the alpha-beta hydrolase superfamily
JR346_RS03360	COG2223	nitrite transmembrane transporter activity
JR346_RS03365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JR346_RS03375	COG0833	amino acid
JR346_RS03420	COG2838	Isocitrate dehydrogenase
JR346_RS03435	COG0823	Involved in the tonB-independent uptake of proteins
JR346_RS03435	COG1506	peptidase
JR346_RS03445	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JR346_RS03455	COG0166	Belongs to the GPI family
JR346_RS03465	COG1217	gtp-binding protein TYPA
JR346_RS03470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR346_RS03495	COG2161	toxin-antitoxin pair type II binding
JR346_RS03500	COG4115	mRNA cleavage
JR346_RS03505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JR346_RS03510	COG2171	N-acyltransferase activity
JR346_RS03515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR346_RS03520	COG0765	amino acid transport
JR346_RS03525	COG0765	amino acid transport
JR346_RS03535	COG1126	abc transporter atp-binding protein
JR346_RS03540	COG3599	regulation of cell shape
JR346_RS03550	COG4122	O-methyltransferase activity
JR346_RS03555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JR346_RS03570	COG2239	Acts as a magnesium transporter
JR346_RS03585	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JR346_RS03590	COG3421	Type III restriction
JR346_RS03610	COG0006	proline dipeptidase activity
JR346_RS03615	COG0613	PHP domain protein
JR346_RS03625	COG0513	Belongs to the DEAD box helicase family
JR346_RS03640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JR346_RS03645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JR346_RS03650	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JR346_RS03655	COG3253	May function as heme-dependent peroxidase
JR346_RS03660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JR346_RS03665	COG0181	hydroxymethylbilane synthase activity
JR346_RS03680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JR346_RS03700	COG0210	DNA helicase
JR346_RS03715	COG0210	DNA helicase
JR346_RS03730	COG3480	Lon protease (S16) C-terminal proteolytic domain
JR346_RS03735	COG1615	UPF0182 protein
JR346_RS03780	COG0483	inositol monophosphate 1-phosphatase activity
JR346_RS03790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JR346_RS03800	COG1595	DNA-templated transcription, initiation
JR346_RS03815	COG0567	Dehydrogenase, E1 component
JR346_RS03815	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR346_RS03820	COG1253	flavin adenine dinucleotide binding
JR346_RS03835	COG1121	(ABC) transporter
JR346_RS03840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR346_RS03850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JR346_RS03860	COG1643	Atp-dependent helicase
JR346_RS03910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JR346_RS03915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JR346_RS03945	COG0018	arginyl-trna synthetase
JR346_RS03950	COG0019	diaminopimelate decarboxylase activity
JR346_RS03955	COG0460	homoserine dehydrogenase
JR346_RS03960	COG0083	homoserine kinase activity
JR346_RS03970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JR346_RS03975	COG2890	protein-(glutamine-N5) methyltransferase activity
JR346_RS04010	COG0356	it plays a direct role in the translocation of protons across the membrane
JR346_RS04015	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JR346_RS04020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JR346_RS04025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JR346_RS04030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JR346_RS04035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JR346_RS04040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JR346_RS04045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JR346_RS04050	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
JR346_RS04090	COG2340	Cysteine-rich secretory protein family
JR346_RS04095	COG1335	isochorismatase
JR346_RS04105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JR346_RS04115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JR346_RS04125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JR346_RS04130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JR346_RS04135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR346_RS04145	COG0420	3'-5' exonuclease activity
JR346_RS04150	COG0419	ATPase involved in DNA repair
JR346_RS04175	COG1295	ribonuclease BN
JR346_RS04180	COG0579	oxidoreductase
JR346_RS04185	COG0747	negative chemotaxis
JR346_RS04225	COG0440	acetolactate synthase activity
JR346_RS04230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JR346_RS04235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JR346_RS04255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JR346_RS04260	COG0473	3-isopropylmalate dehydrogenase activity
JR346_RS04265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR346_RS04270	COG0179	Fumarylacetoacetate (FAA) hydrolase
JR346_RS04275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JR346_RS04305	COG1414	Transcriptional regulator
JR346_RS04310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JR346_RS04315	COG0066	3-isopropylmalate dehydratase activity
JR346_RS04320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JR346_RS04330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JR346_RS04335	COG1181	Belongs to the D-alanine--D-alanine ligase family
JR346_RS04355	COG1461	Dihydroxyacetone kinase
JR346_RS04360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JR346_RS04375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JR346_RS04385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JR346_RS04390	COG0571	ribonuclease III activity
JR346_RS04395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JR346_RS04400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR346_RS04405	COG0318	PFAM AMP-dependent synthetase and ligase
JR346_RS04410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JR346_RS04415	COG1196	nuclear chromosome segregation
JR346_RS04435	COG0708	Exodeoxyribonuclease III
JR346_RS04455	COG0228	four-way junction DNA binding
JR346_RS04460	COG1837	Belongs to the UPF0109 family
JR346_RS04465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JR346_RS04470	COG0336	Belongs to the RNA methyltransferase TrmD family
JR346_RS04480	COG0335	large ribosomal subunit rRNA binding
JR346_RS04485	COG0681	Belongs to the peptidase S26 family
JR346_RS04495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JR346_RS04505	COG0792	nuclease activity
JR346_RS04515	COG0758	DNA mediated transformation
JR346_RS04520	COG4974	Belongs to the 'phage' integrase family
JR346_RS04530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JR346_RS04535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR346_RS04540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JR346_RS04550	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JR346_RS04575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JR346_RS04580	COG1045	serine acetyltransferase
JR346_RS04590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JR346_RS04595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JR346_RS04600	COG3022	response to hydroperoxide
JR346_RS04610	COG0242	peptide deformylase activity
JR346_RS04645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JR346_RS04645	COG5479	isomerase activity
JR346_RS04670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR346_RS04675	COG1946	Acyl-CoA thioesterase
JR346_RS04710	COG0525	valine-tRNA ligase activity
JR346_RS04715	COG4221	oxidoreductase activity
JR346_RS04730	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JR346_RS04765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JR346_RS04790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JR346_RS04800	COG3153	acetyltransferase
JR346_RS04800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JR346_RS04805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JR346_RS04805	COG1648	precorrin-2 dehydrogenase activity
JR346_RS04810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JR346_RS04815	COG0285	dihydrofolate synthase activity
JR346_RS04835	COG1530	ribonuclease E activity
JR346_RS04840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JR346_RS04845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JR346_RS04850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JR346_RS04855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JR346_RS04860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JR346_RS04870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JR346_RS04880	COG0799	negative regulation of ribosome biogenesis
JR346_RS04895	COG2813	Specifically methylates the guanine in position
JR346_RS04930	COG1780	Probably involved in ribonucleotide reductase function
JR346_RS04935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JR346_RS04945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JR346_RS04960	COG2135	peptidase activity
JR346_RS04970	COG0179	Fumarylacetoacetate (FAA) hydrolase
JR346_RS04990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JR346_RS05015	COG2161	toxin-antitoxin pair type II binding
JR346_RS05020	COG4115	mRNA cleavage
JR346_RS05025	COG2272	Belongs to the type-B carboxylesterase lipase family
JR346_RS05035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JR346_RS05050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JR346_RS05060	COG0217	transcriptional regulatory protein
JR346_RS05065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JR346_RS05070	COG0632	four-way junction helicase activity
JR346_RS05075	COG2255	four-way junction helicase activity
JR346_RS05085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JR346_RS05090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JR346_RS05095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JR346_RS05105	COG1196	nuclear chromosome segregation
JR346_RS05110	COG0124	histidyl-tRNA synthetase
JR346_RS05115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JR346_RS05135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JR346_RS05150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JR346_RS05165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JR346_RS05170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JR346_RS05180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JR346_RS05185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JR346_RS05190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JR346_RS05195	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JR346_RS05200	COG0540	Belongs to the ATCase OTCase family
JR346_RS05205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JR346_RS05215	COG0505	Belongs to the CarA family
JR346_RS05220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JR346_RS05225	COG0284	orotidine-5'-phosphate decarboxylase activity
JR346_RS05230	COG0194	GDP metabolic process
JR346_RS05235	COG0194	GDP metabolic process
JR346_RS05240	COG1758	RNA polymerase activity
JR346_RS05250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JR346_RS05260	COG0438	transferase activity, transferring glycosyl groups
JR346_RS05270	COG0495	leucyl-tRNA aminoacylation
JR346_RS05275	COG1307	EDD domain protein, DegV family
JR346_RS05290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR346_RS05300	COG0268	Binds directly to 16S ribosomal RNA
JR346_RS05310	COG0481	GTPase activity
JR346_RS05330	COG1420	regulation of RNA biosynthetic process
JR346_RS05335	COG0484	heat shock protein binding
JR346_RS05340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JR346_RS05350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JR346_RS05360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JR346_RS05365	COG1316	TRANSCRIPTIONal
JR346_RS05370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JR346_RS05375	COG1381	Involved in DNA repair and RecF pathway recombination
JR346_RS05380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JR346_RS05385	COG0167	dihydroorotate dehydrogenase activity
JR346_RS05405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JR346_RS05410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JR346_RS05420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JR346_RS05425	COG0723	plastoquinol--plastocyanin reductase activity
JR346_RS05435	COG1845	cytochrome c oxidase, subunit III
JR346_RS05440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JR346_RS05455	COG1216	Glycosyl transferase, family 2
JR346_RS05470	COG0805	protein transport
JR346_RS05475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JR346_RS05500	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JR346_RS05510	COG4122	O-methyltransferase activity
JR346_RS05515	COG1222	aaa ATPase
JR346_RS05530	COG1994	Peptidase M50
JR346_RS05540	COG0215	cysteine-tRNA ligase activity
JR346_RS05545	COG1968	undecaprenyl-diphosphatase activity
JR346_RS05560	COG0039	L-malate dehydrogenase activity
JR346_RS05580	COG1316	TRANSCRIPTIONal
JR346_RS05585	COG0254	rRNA binding
JR346_RS05595	COG1119	ATPase activity
JR346_RS05605	COG1028	Short-chain dehydrogenase reductase Sdr
JR346_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
JR346_RS05650	COG0488	(ABC) transporter
JR346_RS05655	COG1268	BioY protein
JR346_RS05660	COG1122	ATPase activity
JR346_RS05695	COG2151	metal-sulfur cluster biosynthetic enzyme
JR346_RS05700	COG0396	ATPase activity
JR346_RS05705	COG0719	Fe-S assembly protein
JR346_RS05740	COG0109	protoheme IX farnesyltransferase activity
JR346_RS05750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JR346_RS05770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JR346_RS05780	COG0126	phosphoglycerate kinase activity
JR346_RS05785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JR346_RS05790	COG1481	regulation of sporulation
JR346_RS05800	COG1660	Displays ATPase and GTPase activities
JR346_RS05805	COG0322	excinuclease ABC activity
JR346_RS05810	COG0318	PFAM AMP-dependent synthetase and ligase
JR346_RS05810	COG0204	Acyl-transferase
JR346_RS05840	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JR346_RS05850	COG2274	protein secretion by the type I secretion system
JR346_RS05885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JR346_RS05890	COG0747	negative chemotaxis
JR346_RS05895	COG1136	(ABC) transporter
JR346_RS05900	COG1136	(ABC) transporter
JR346_RS05900	COG0577	efflux transmembrane transporter activity
JR346_RS05930	COG0556	nucleotide-excision repair
JR346_RS05935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JR346_RS05940	COG0237	dephospho-CoA kinase activity
JR346_RS05940	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JR346_RS05945	COG1739	Uncharacterized protein family UPF0029
JR346_RS05950	COG0539	negative regulation of cytoplasmic translation
JR346_RS05965	COG2050	protein possibly involved in aromatic compounds catabolism
JR346_RS05990	COG0469	pyruvate kinase activity
JR346_RS06010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JR346_RS06015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JR346_RS06020	COG0740	serine-type endopeptidase activity
JR346_RS06050	COG0544	peptidyl-prolyl cis-trans isomerase activity
JR346_RS06070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JR346_RS06075	COG0159	tryptophan synthase activity
JR346_RS06110	COG0107	imidazoleglycerol-phosphate synthase activity
JR346_RS06115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JR346_RS06120	COG0140	phosphoribosyl-ATP diphosphatase activity
JR346_RS06125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JR346_RS06130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JR346_RS06130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JR346_RS06135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JR346_RS06135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JR346_RS06165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JR346_RS06175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JR346_RS06180	COG0242	peptide deformylase activity
JR346_RS06240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JR346_RS06255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JR346_RS06265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JR346_RS06270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JR346_RS06275	COG0531	amino acid
JR346_RS06280	COG0569	domain protein
JR346_RS06305	COG0756	dUTP diphosphatase activity
JR346_RS06355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JR346_RS06380	COG0039	L-malate dehydrogenase activity
JR346_RS06385	COG0187	DNA topoisomerase II activity
JR346_RS06395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JR346_RS06410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JR346_RS06415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JR346_RS06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR346_RS06435	COG0321	lipoyl(octanoyl) transferase activity
JR346_RS06440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JR346_RS06455	COG0174	glutamine synthetase
JR346_RS06465	COG3527	Alpha-acetolactate decarboxylase
JR346_RS06470	COG5006	permease, DMT superfamily
JR346_RS06480	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JR346_RS06485	COG0174	glutamine synthetase
JR346_RS06490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JR346_RS06510	COG0058	SHG alpha-glucan phosphorylase activity
JR346_RS06515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JR346_RS06525	COG0297	glycogen (starch) synthase activity
JR346_RS06535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JR346_RS06540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JR346_RS06545	COG0587	DNA-directed DNA polymerase activity
JR346_RS06555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JR346_RS06560	COG3599	regulation of cell shape
JR346_RS06570	COG1799	cell septum assembly
JR346_RS06580	COG1496	oxidoreductase activity
JR346_RS06585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JR346_RS06590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JR346_RS06595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JR346_RS06600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JR346_RS06605	COG0772	Belongs to the SEDS family
JR346_RS06610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JR346_RS06615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JR346_RS06620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JR346_RS06625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JR346_RS06630	COG0768	penicillin binding
JR346_RS06640	COG0275	rRNA processing
JR346_RS06645	COG2001	Belongs to the MraZ family
JR346_RS06655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JR346_RS06660	COG0142	geranyltranstransferase activity
JR346_RS06670	COG0515	serine threonine protein kinase
JR346_RS06675	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JR346_RS06705	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JR346_RS06720	COG1716	ATPase activity
JR346_RS06725	COG0509	glycine decarboxylation via glycine cleavage system
JR346_RS06735	COG0583	DNA-binding transcription factor activity
JR346_RS06755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JR346_RS06760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JR346_RS06765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JR346_RS06790	COG2818	Glycosylase
JR346_RS06860	COG0500	methyltransferase
JR346_RS06885	COG1160	GTP binding
JR346_RS06890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JR346_RS06905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JR346_RS06910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JR346_RS06935	COG2079	MmgE PrpD family protein
JR346_RS06940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JR346_RS06955	COG1051	belongs to the nudix hydrolase family
JR346_RS06965	COG0497	DNA recombination
JR346_RS06970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JR346_RS06985	COG0647	UMP catabolic process
JR346_RS07005	COG1216	Glycosyl transferase, family 2
JR346_RS07015	COG1674	ftsk spoiiie
JR346_RS07015	COG0433	COG0433 Predicted ATPase
JR346_RS07065	COG0653	protein targeting
JR346_RS07070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JR346_RS07075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JR346_RS07080	COG5401	PFAM Sporulation and spore germination
JR346_RS07085	COG5002	protein histidine kinase activity
JR346_RS07090	COG0745	RESPONSE REGULATOR receiver
JR346_RS07105	COG0482	sulfurtransferase activity
JR346_RS07115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JR346_RS07120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JR346_RS07125	COG2086	electron transfer activity
JR346_RS07130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR346_RS07140	COG1842	Phage shock protein A
JR346_RS07165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JR346_RS07180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JR346_RS07190	COG0165	Argininosuccinate lyase
JR346_RS07195	COG0137	argininosuccinate synthase activity
JR346_RS07205	COG5002	protein histidine kinase activity
JR346_RS07205	COG3850	Histidine kinase
JR346_RS07210	COG0745	RESPONSE REGULATOR receiver
JR346_RS07220	COG1929	Belongs to the glycerate kinase type-1 family
JR346_RS07225	COG0318	PFAM AMP-dependent synthetase and ligase
JR346_RS07235	COG1438	arginine binding
JR346_RS07240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JR346_RS07245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JR346_RS07250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JR346_RS07255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JR346_RS07260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JR346_RS07265	COG0813	purine-nucleoside phosphorylase activity
JR346_RS07275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR346_RS07275	COG0072	phenylalanine-tRNA ligase activity
JR346_RS07280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JR346_RS07300	COG0494	nUDIX hydrolase
JR346_RS07320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JR346_RS07325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JR346_RS07330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JR346_RS07345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JR346_RS07355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JR346_RS07360	COG0131	Imidazoleglycerol-phosphate dehydratase
JR346_RS07365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JR346_RS07375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JR346_RS07385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JR346_RS07390	COG2813	Specifically methylates the guanine in position
JR346_RS07395	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JR346_RS07400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JR346_RS07405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JR346_RS07415	COG2137	regulation of response to DNA damage stimulus
JR346_RS07420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JR346_RS07430	COG1396	sequence-specific DNA binding
JR346_RS07435	COG1546	Belongs to the CinA family
JR346_RS07435	COG1058	Belongs to the CinA family
JR346_RS07445	COG1674	ftsk spoiiie
JR346_RS07455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JR346_RS07465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JR346_RS07475	COG0612	Peptidase, M16
JR346_RS07480	COG1185	polyribonucleotide nucleotidyltransferase activity
JR346_RS07485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JR346_RS07500	COG1854	S-ribosylhomocysteine lyase activity
JR346_RS07505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JR346_RS07515	COG0196	riboflavin kinase activity
JR346_RS07530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JR346_RS07535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JR346_RS07540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JR346_RS07555	COG0779	Required for maturation of 30S ribosomal subunits
JR346_RS07570	COG0442	prolyl-tRNA aminoacylation
JR346_RS07580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JR346_RS07585	COG0750	zinc metalloprotease
JR346_RS07590	COG1882	Formate acetyltransferase
JR346_RS07600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JR346_RS07605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JR346_RS07615	COG1132	(ABC) transporter
JR346_RS07620	COG2261	transglycosylase associated protein
JR346_RS07625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR346_RS07645	COG0233	cytoplasmic translational termination
JR346_RS07650	COG0528	UMP kinase activity
JR346_RS07655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JR346_RS07660	COG0052	Belongs to the universal ribosomal protein uS2 family
JR346_RS07710	COG0582	viral genome integration into host DNA
JR346_RS07740	COG0358	DNA primase activity
JR346_RS07780	COG0423	glycine-tRNA ligase activity
JR346_RS07785	COG2501	S4 domain
JR346_RS07795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JR346_RS07800	COG2873	o-acetylhomoserine
JR346_RS07810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JR346_RS07815	COG0154	amidase activity
JR346_RS07820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JR346_RS07830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JR346_RS07835	COG0631	protein serine/threonine phosphatase activity
JR346_RS07850	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JR346_RS07850	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JR346_RS07860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JR346_RS07875	COG0673	inositol 2-dehydrogenase activity
JR346_RS07880	COG1301	dicarboxylic acid transport
JR346_RS07885	COG2902	Dehydrogenase
JR346_RS07890	COG0424	maF-like protein
JR346_RS07895	COG4770	biotin carboxylase activity
JR346_RS07910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JR346_RS07915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JR346_RS08005	COG0193	aminoacyl-tRNA hydrolase activity
JR346_RS08010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JR346_RS08020	COG1088	dTDP-glucose 4,6-dehydratase activity
JR346_RS08025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JR346_RS08030	COG0489	protein tyrosine kinase activity
JR346_RS08045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JR346_RS08045	COG0438	transferase activity, transferring glycosyl groups
JR346_RS08050	COG0463	Glycosyl transferase, family 2
JR346_RS08090	COG2089	acid synthase
JR346_RS08095	COG1083	cytidylyl-transferase
JR346_RS08125	COG1132	(ABC) transporter
JR346_RS08130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JR346_RS08135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JR346_RS08145	COG0488	(ABC) transporter
JR346_RS08155	COG0438	transferase activity, transferring glycosyl groups
JR346_RS08170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JR346_RS08175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JR346_RS08185	COG0084	hydrolase, TatD family'
JR346_RS08235	COG1316	TRANSCRIPTIONal
JR346_RS08255	COG0288	reversible hydration of carbon dioxide
JR346_RS08260	COG0114	fumarate hydratase activity
JR346_RS08275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JR346_RS08290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR346_RS08300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JR346_RS08305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JR346_RS08320	COG0561	phosphatase activity
JR346_RS08350	COG0148	phosphopyruvate hydratase activity
JR346_RS08355	COG3956	TIGRFAM MazG family protein
JR346_RS08360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JR346_RS08380	COG1079	Belongs to the binding-protein-dependent transport system permease family
JR346_RS08385	COG4603	Belongs to the binding-protein-dependent transport system permease family
JR346_RS08390	COG3845	ABC transporter
JR346_RS08400	COG1473	amidohydrolase
JR346_RS08400	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JR346_RS08405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JR346_RS08410	COG1053	succinate dehydrogenase
JR346_RS08420	COG2009	succinate dehydrogenase
JR346_RS08435	COG0180	Tryptophanyl-tRNA synthetase
JR346_RS08445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JR346_RS08450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JR346_RS08480	COG0300	oxidoreductase activity
JR346_RS08500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JR346_RS08515	COG0738	Major facilitator superfamily
JR346_RS08525	COG2354	Protein conserved in bacteria
JR346_RS08530	COG0656	L-ascorbic acid biosynthetic process
JR346_RS08555	COG2814	Major facilitator Superfamily
JR346_RS08560	COG1113	amino acid transport
JR346_RS08570	COG1115	amino acid carrier protein
JR346_RS08575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JR346_RS08580	COG1115	amino acid carrier protein
JR346_RS08585	COG0789	Transcriptional regulator
JR346_RS08590	COG0484	heat shock protein binding
JR346_RS08600	COG0443	Heat shock 70 kDa protein
JR346_RS08605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JR346_RS08615	COG2814	Major facilitator Superfamily
JR346_RS08625	COG1064	alcohol dehydrogenase
JR346_RS08635	COG1122	ATPase activity
JR346_RS08640	COG4721	ABC-type cobalt transport system, permease component
JR346_RS08665	COG0717	Belongs to the dCTP deaminase family
JR346_RS08700	COG3336	cytochrome c oxidase
JR346_RS08720	COG0776	regulation of translation
JR346_RS08725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JR346_RS08730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JR346_RS08735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JR346_RS08745	COG1120	ATPase activity
JR346_RS08750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR346_RS08755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR346_RS08760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR346_RS08765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JR346_RS08765	COG2755	lipolytic protein G-D-S-L family
JR346_RS08825	COG0215	cysteine-tRNA ligase activity
JR346_RS08830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JR346_RS08835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JR346_RS08850	COG0366	Alpha amylase catalytic
JR346_RS08870	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
JR346_RS08880	COG2197	response regulator
JR346_RS08890	COG1063	alcohol dehydrogenase
JR346_RS08895	COG0745	RESPONSE REGULATOR receiver
JR346_RS08900	COG5002	protein histidine kinase activity
JR346_RS08920	COG0588	phosphoglycerate mutase activity
JR346_RS08930	COG0626	cystathionine gamma-synthase activity
JR346_RS08935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JR346_RS08950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JR346_RS08955	COG0488	(ABC) transporter
JR346_RS08965	COG1959	2 iron, 2 sulfur cluster binding
JR346_RS08975	COG1129	ABC transporter
JR346_RS08980	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
JR346_RS09005	COG1201	RNA secondary structure unwinding
JR346_RS09015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JR346_RS09035	COG0659	secondary active sulfate transmembrane transporter activity
JR346_RS09085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JR346_RS09130	COG1002	Type II restriction enzyme, methylase subunits
JR346_RS09160	COG1113	amino acid transport
JR346_RS09165	COG1113	amino acid transport
JR346_RS09175	COG1309	transcriptional regulator
JR346_RS09200	COG3201	nicotinamide mononucleotide transporter
JR346_RS09220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JR346_RS09260	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JR346_RS09265	COG0047	phosphoribosylformylglycinamidine synthase activity
JR346_RS09270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JR346_RS09290	COG2153	protein acetylation
JR346_RS09305	COG0601	transmembrane transport
JR346_RS09320	COG4172	Belongs to the ABC transporter superfamily
JR346_RS09340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JR346_RS09345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JR346_RS09355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JR346_RS09370	COG0561	phosphatase activity
JR346_RS09375	COG1126	abc transporter atp-binding protein
JR346_RS09380	COG0765	amino acid transport
JR346_RS09385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR346_RS09390	COG0626	cystathionine gamma-synthase activity
JR346_RS09405	COG1832	CoA-binding protein
JR346_RS09415	COG0586	Pfam SNARE associated Golgi protein
JR346_RS09430	COG0129	dihydroxy-acid dehydratase activity
JR346_RS09465	COG1518	maintenance of DNA repeat elements
JR346_RS09470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JR346_RS09475	COG2197	response regulator
JR346_RS09480	COG4585	Histidine kinase
JR346_RS09485	COG2188	Transcriptional regulator
JR346_RS09490	COG0366	Alpha amylase catalytic
JR346_RS09540	COG1012	belongs to the aldehyde dehydrogenase family
JR346_RS09550	COG2357	RelA SpoT domain protein
JR346_RS09595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JR346_RS09600	COG1404	Belongs to the peptidase S8 family
JR346_RS09620	COG1362	aminopeptidase activity
JR346_RS09630	COG1266	CAAX protease self-immunity
JR346_RS09645	COG5650	phosphatidylinositol metabolic process
JR346_RS09665	COG0741	lytic transglycosylase activity
JR346_RS09670	COG0584	glycerophosphoryl diester phosphodiesterase
JR346_RS09680	COG2188	Transcriptional regulator
JR346_RS09685	COG3718	enzyme involved in inositol metabolism
JR346_RS09700	COG0673	inositol 2-dehydrogenase activity
JR346_RS09705	COG1082	Xylose isomerase domain protein TIM barrel
JR346_RS09710	COG1609	Transcriptional regulator
JR346_RS09715	COG2814	Major facilitator Superfamily
JR346_RS09720	COG1082	Xylose isomerase domain protein TIM barrel
JR346_RS09725	COG0673	inositol 2-dehydrogenase activity
JR346_RS09740	COG3962	Belongs to the TPP enzyme family
JR346_RS09750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR346_RS09770	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR346_RS09800	COG0667	Aldo Keto reductase
JR346_RS09810	COG2814	Major facilitator Superfamily
JR346_RS09815	COG3590	peptidase
JR346_RS09820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JR346_RS09825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JR346_RS09830	COG4770	biotin carboxylase activity
JR346_RS09840	COG1914	H( )-stimulated, divalent metal cation uptake system
JR346_RS09850	COG0803	Belongs to the bacterial solute-binding protein 9 family
JR346_RS09860	COG1121	(ABC) transporter
JR346_RS09865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR346_RS09880	COG1476	TRANSCRIPTIONal
JR346_RS09885	COG0693	protein deglycase activity
JR346_RS09910	COG2040	homocysteine
JR346_RS09915	COG0833	amino acid
JR346_RS09930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JR346_RS09935	COG0702	epimerase
JR346_RS09940	COG3961	Belongs to the TPP enzyme family
JR346_RS09945	COG1115	amino acid carrier protein
JR346_RS09950	COG1525	nuclease
JR346_RS09950	COG4085	toxin activity
JR346_RS09950	COG0737	Belongs to the 5'-nucleotidase family
JR346_RS09960	COG0415	Belongs to the DNA photolyase family
JR346_RS09975	COG1716	ATPase activity
JR346_RS09995	COG0515	serine threonine protein kinase
JR346_RS10015	COG3764	Sortase (surface protein transpeptidase)
JR346_RS10030	COG2353	YceI-like domain
JR346_RS10040	COG0583	DNA-binding transcription factor activity
JR346_RS10055	COG3250	beta-galactosidase activity
JR346_RS10060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JR346_RS10095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR346_RS10105	COG1902	pentaerythritol trinitrate reductase activity
JR346_RS10160	COG1929	Belongs to the glycerate kinase type-1 family
JR346_RS10165	COG2860	membrane
JR346_RS10170	COG2076	Multidrug Resistance protein
JR346_RS10180	COG0359	binds to the 23S rRNA
JR346_RS10185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JR346_RS10195	COG0360	Binds together with S18 to 16S ribosomal RNA
JR346_RS10210	COG2197	response regulator
JR346_RS10215	COG4585	Histidine kinase
JR346_RS10225	COG1131	(ABC) transporter
JR346_RS10250	COG0492	ferredoxin-NADP+ reductase activity
JR346_RS10255	COG3118	belongs to the thioredoxin family
JR346_RS10260	COG2116	formate transmembrane transporter activity
JR346_RS10275	COG1192	Involved in chromosome partitioning
JR346_RS10280	COG0357	Ribosomal RNA small subunit methyltransferase G
JR346_RS10290	COG0706	membrane insertase activity
JR346_RS10295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JR346_RS10300	COG0594	ribonuclease P activity
JR346_RS10305	COG0230	Belongs to the bacterial ribosomal protein bL34 family