locus-tag	class	description
H2866_RS00070	COG2814	Major facilitator Superfamily
H2866_RS00080	COG3384	dioxygenase
H2866_RS00090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H2866_RS00115	COG2244	polysaccharide biosynthetic process
H2866_RS00155	COG0583	DNA-binding transcription factor activity
H2866_RS00160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2866_RS00165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2866_RS00170	COG2828	Protein conserved in bacteria
H2866_RS00180	COG4608	Belongs to the ABC transporter superfamily
H2866_RS00185	COG0444	Belongs to the ABC transporter superfamily
H2866_RS00190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS00195	COG0601	transmembrane transport
H2866_RS00200	COG0747	negative chemotaxis
H2866_RS00205	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H2866_RS00215	COG1473	amidohydrolase
H2866_RS00220	COG1473	amidohydrolase
H2866_RS00235	COG0582	viral genome integration into host DNA
H2866_RS00240	COG0583	DNA-binding transcription factor activity
H2866_RS00275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2866_RS00310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2866_RS00315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2866_RS00320	COG5002	protein histidine kinase activity
H2866_RS00325	COG0745	RESPONSE REGULATOR receiver
H2866_RS00355	COG1917	Cupin 2, conserved barrel domain protein
H2866_RS00380	COG0667	Aldo Keto reductase
H2866_RS00475	COG4771	TonB-dependent receptor
H2866_RS00480	COG2819	hydrolase of the alpha beta superfamily
H2866_RS00495	COG2382	esterase
H2866_RS00505	COG3122	Protein conserved in bacteria
H2866_RS00520	COG0583	DNA-binding transcription factor activity
H2866_RS00525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H2866_RS00535	COG2706	6-phosphogluconolactonase activity
H2866_RS00540	COG2814	Major facilitator Superfamily
H2866_RS00545	COG1082	Xylose isomerase domain protein TIM barrel
H2866_RS00555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2866_RS00585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2866_RS00600	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2866_RS00630	COG2977	Belongs to the P-Pant transferase superfamily
H2866_RS00640	COG2011	ABC-type metal ion transport system permease component
H2866_RS00655	COG3391	amine dehydrogenase activity
H2866_RS00670	COG1175	transmembrane transport
H2866_RS00675	COG3842	ATPase activity
H2866_RS00695	COG1388	LysM domain
H2866_RS00695	COG1470	cell adhesion involved in biofilm formation
H2866_RS00700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2866_RS00705	COG0436	Aminotransferase
H2866_RS00710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2866_RS00730	COG0765	amino acid transport
H2866_RS00745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2866_RS00750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H2866_RS00755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H2866_RS00760	COG1984	allophanate hydrolase subunit 2
H2866_RS00770	COG2207	Transcriptional regulator
H2866_RS00775	COG2926	Belongs to the UPF0265 family
H2866_RS00780	COG1289	transmembrane transporter activity
H2866_RS00815	COG1733	regulation of RNA biosynthetic process
H2866_RS00820	COG0702	epimerase
H2866_RS00865	COG0583	DNA-binding transcription factor activity
H2866_RS00880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2866_RS00880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2866_RS00895	COG1609	Transcriptional regulator
H2866_RS00920	COG0583	DNA-binding transcription factor activity
H2866_RS00925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2866_RS00935	COG1811	Na channel or pump
H2866_RS00960	COG2925	Exonuclease
H2866_RS00965	COG0531	amino acid
H2866_RS00970	COG0174	glutamine synthetase
H2866_RS00975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H2866_RS00980	COG1129	ABC transporter
H2866_RS00985	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS00990	COG1120	ATPase activity
H2866_RS00995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2866_RS01000	COG0833	amino acid
H2866_RS01005	COG0583	DNA-binding transcription factor activity
H2866_RS01010	COG2855	membrane
H2866_RS01025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2866_RS01025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2866_RS01025	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H2866_RS01030	COG1105	Belongs to the carbohydrate kinase PfkB family
H2866_RS01050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2866_RS01055	COG0246	Mannitol dehydrogenase
H2866_RS01060	COG2186	Transcriptional regulator
H2866_RS01065	COG0583	DNA-binding transcription factor activity
H2866_RS01075	COG0523	cobalamin synthesis protein
H2866_RS01080	COG0671	phosphoesterase, PA-phosphatase related
H2866_RS01085	COG0791	NLP P60 protein
H2866_RS01090	COG4166	transmembrane transport
H2866_RS01095	COG4174	ABC transporter (Permease)
H2866_RS01100	COG4239	(ABC) transporter, permease
H2866_RS01105	COG4172	Belongs to the ABC transporter superfamily
H2866_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS01140	COG1609	Transcriptional regulator
H2866_RS01150	COG2814	Major facilitator Superfamily
H2866_RS01155	COG1187	pseudouridine synthase activity
H2866_RS01160	COG1061	Type III restriction enzyme res subunit
H2866_RS01165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H2866_RS01170	COG3081	Nucleoid-associated protein
H2866_RS01175	COG3082	Protein of unknown function (DUF1414)
H2866_RS01205	COG0306	phosphate transporter
H2866_RS01215	COG0076	glutamate decarboxylase activity
H2866_RS01220	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H2866_RS01235	COG4774	siderophore transport
H2866_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS01265	COG0823	Involved in the tonB-independent uptake of proteins
H2866_RS01275	COG3093	addiction module antidote protein HigA
H2866_RS01285	COG0300	oxidoreductase activity
H2866_RS01290	COG2207	Transcriptional regulator
H2866_RS01295	COG0740	serine-type endopeptidase activity
H2866_RS01305	COG2814	Major facilitator Superfamily
H2866_RS01310	COG1349	DNA-binding transcription factor activity
H2866_RS01325	COG0671	phosphoesterase, PA-phosphatase related
H2866_RS01340	COG3038	cytochrome b561
H2866_RS01345	COG0401	homolog of Blt101
H2866_RS01360	COG0768	penicillin binding
H2866_RS01365	COG2207	Transcriptional regulator
H2866_RS01390	COG2223	nitrite transmembrane transporter activity
H2866_RS01400	COG2197	response regulator
H2866_RS01405	COG2205	protein histidine kinase activity
H2866_RS01405	COG0784	Response regulator, receiver
H2866_RS01415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2866_RS01420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2866_RS01425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2866_RS01430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2866_RS01450	COG4575	ribosome binding
H2866_RS01455	COG1007	ATP synthesis coupled electron transport
H2866_RS01460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2866_RS01465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2866_RS01470	COG0713	ATP synthesis coupled electron transport
H2866_RS01475	COG0839	Belongs to the complex I subunit 6 family
H2866_RS01485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H2866_RS01490	COG1034	ATP synthesis coupled electron transport
H2866_RS01495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H2866_RS01505	COG0649	NAD binding
H2866_RS01505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2866_RS01515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2866_RS01520	COG0583	DNA-binding transcription factor activity
H2866_RS01525	COG0436	Aminotransferase
H2866_RS01530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H2866_RS01535	COG3013	Belongs to the UPF0304 family
H2866_RS01540	COG3092	negative regulation of chromosome organization
H2866_RS01545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2866_RS01550	COG0857	belongs to the CobB CobQ family
H2866_RS01550	COG0280	phosphate acetyltransferase
H2866_RS01565	COG1609	Transcriptional regulator
H2866_RS01570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H2866_RS01575	COG0625	glutathione transferase activity
H2866_RS01580	COG1090	epimerase
H2866_RS01585	COG0747	negative chemotaxis
H2866_RS01590	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2866_RS01600	COG1063	alcohol dehydrogenase
H2866_RS01605	COG1070	Carbohydrate kinase
H2866_RS01610	COG4598	ABC transporter
H2866_RS01615	COG4160	amino acid transport
H2866_RS01620	COG4215	(ABC) transporter
H2866_RS01625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS01630	COG0163	prenyltransferase activity
H2866_RS01635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H2866_RS01640	COG1286	toxin biosynthetic process
H2866_RS01645	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H2866_RS01650	COG0285	dihydrofolate synthase activity
H2866_RS01655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H2866_RS01660	COG0586	Pfam SNARE associated Golgi protein
H2866_RS01670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H2866_RS01675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2866_RS01705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H2866_RS01720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2866_RS01725	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H2866_RS01725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2866_RS01735	COG3101	peptidyl-lysine hydroxylation
H2866_RS01750	COG2890	protein-(glutamine-N5) methyltransferase activity
H2866_RS01755	COG2840	Smr protein MutS2
H2866_RS01760	COG2062	phosphohistidine phosphatase, SixA
H2866_RS01765	COG1024	Enoyl-CoA hydratase
H2866_RS01765	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2866_RS01770	COG0183	Belongs to the thiolase family
H2866_RS01775	COG3691	Protein conserved in bacteria
H2866_RS01790	COG3088	subunit of a heme lyase
H2866_RS01790	COG4235	cytochrome complex assembly
H2866_RS01800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2866_RS01805	COG1138	Cytochrome C-type biogenesis protein
H2866_RS01810	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H2866_RS01815	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2866_RS01820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2866_RS01825	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2866_RS01835	COG2116	formate transmembrane transporter activity
H2866_RS01855	COG3093	addiction module antidote protein HigA
H2866_RS01895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS01900	COG1082	Xylose isomerase domain protein TIM barrel
H2866_RS01910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H2866_RS01915	COG1737	Transcriptional regulator
H2866_RS01915	COG0837	glucose binding
H2866_RS01920	COG3038	cytochrome b561
H2866_RS01925	COG0436	Aminotransferase
H2866_RS01935	COG3275	phosphorelay sensor kinase activity
H2866_RS01955	COG1794	racemase activity, acting on amino acids and derivatives
H2866_RS01970	COG3961	Belongs to the TPP enzyme family
H2866_RS01975	COG0667	Aldo Keto reductase
H2866_RS01985	COG2365	Tyrosine phosphatase family
H2866_RS01990	COG1914	H( )-stimulated, divalent metal cation uptake system
H2866_RS01995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H2866_RS02010	COG2116	formate transmembrane transporter activity
H2866_RS02055	COG4302	ethanolamine ammonia-lyase activity
H2866_RS02060	COG4303	Ethanolamine ammonia lyase large subunit
H2866_RS02065	COG0531	amino acid
H2866_RS02075	COG0583	DNA-binding transcription factor activity
H2866_RS02080	COG0385	Bile acid
H2866_RS02085	COG3530	Putative quorum-sensing-regulated virulence factor
H2866_RS02090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H2866_RS02100	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H2866_RS02115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2866_RS02125	COG2205	protein histidine kinase activity
H2866_RS02130	COG0745	RESPONSE REGULATOR receiver
H2866_RS02135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2866_RS02145	COG4208	sulfate ABC transporter
H2866_RS02150	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H2866_RS02155	COG4150	thiosulfate binding
H2866_RS02160	COG2837	iron assimilation
H2866_RS02175	COG3111	PFAM Bacterial OB fold (BOF) protein
H2866_RS02195	COG0408	coproporphyrinogen oxidase activity
H2866_RS02200	COG1671	Belongs to the UPF0178 family
H2866_RS02210	COG2390	Transcriptional regulator
H2866_RS02215	COG2084	Dehydrogenase
H2866_RS02220	COG1082	Xylose isomerase domain protein TIM barrel
H2866_RS02225	COG0149	triose-phosphate isomerase activity
H2866_RS02230	COG2376	Dihydroxyacetone kinase
H2866_RS02240	COG0698	ribose 5-phosphate isomerase
H2866_RS02245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2866_RS02250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2866_RS02255	COG5342	invasion associated locus B
H2866_RS02265	COG0494	nUDIX hydrolase
H2866_RS02270	COG2197	response regulator
H2866_RS02280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2866_RS02295	COG1393	Belongs to the ArsC family
H2866_RS02300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2866_RS02305	COG1876	peptidase activity
H2866_RS02315	COG0400	carboxylic ester hydrolase activity
H2866_RS02320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H2866_RS02330	COG2707	UPF0756 membrane protein
H2866_RS02335	COG2321	neutral zinc metallopeptidase
H2866_RS02340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H2866_RS02345	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H2866_RS02350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2866_RS02355	COG2716	regulation of RNA biosynthetic process
H2866_RS02360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2866_RS02365	COG0628	permease
H2866_RS02370	COG4783	chaperone-mediated protein folding
H2866_RS02375	COG1393	Belongs to the ArsC family
H2866_RS02380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2866_RS02385	COG2233	PERMEase
H2866_RS02400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2866_RS02405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2866_RS02410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H2866_RS02420	COG2200	EAL domain
H2866_RS02430	COG2239	Acts as a magnesium transporter
H2866_RS02440	COG1294	oxidase, subunit
H2866_RS02445	COG1271	oxidase subunit
H2866_RS02455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H2866_RS02460	COG0443	Heat shock 70 kDa protein
H2866_RS02465	COG0667	Aldo Keto reductase
H2866_RS02470	COG2814	Major facilitator Superfamily
H2866_RS02475	COG2205	protein histidine kinase activity
H2866_RS02480	COG0745	RESPONSE REGULATOR receiver
H2866_RS02485	COG3422	double-strand break repair
H2866_RS02490	COG0826	peptidase U32
H2866_RS02495	COG1597	lipid kinase activity
H2866_RS02500	COG4948	Mandelate Racemase Muconate Lactonizing
H2866_RS02505	COG1063	alcohol dehydrogenase
H2866_RS02510	COG2271	Major facilitator Superfamily
H2866_RS02520	COG1802	Transcriptional regulator
H2866_RS02530	COG0351	phosphomethylpyrimidine kinase
H2866_RS02535	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H2866_RS02575	COG0583	DNA-binding transcription factor activity
H2866_RS02585	COG0402	S-adenosylhomocysteine deaminase activity
H2866_RS02590	COG0251	oxidation-reduction process
H2866_RS02610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2866_RS02615	COG0277	FAD linked oxidase domain protein
H2866_RS02640	COG0583	DNA-binding transcription factor activity
H2866_RS02645	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2866_RS02655	COG0517	IMP dehydrogenase activity
H2866_RS02655	COG0516	GMP reductase activity
H2866_RS02670	COG2271	Major facilitator Superfamily
H2866_RS02680	COG0753	catalase activity
H2866_RS02685	COG1160	GTP binding
H2866_RS02690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2866_RS02695	COG2976	Protein conserved in bacteria
H2866_RS02700	COG0124	histidyl-tRNA synthetase
H2866_RS02705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H2866_RS02720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H2866_RS02725	COG0105	UTP biosynthetic process
H2866_RS02730	COG4953	penicillin-binding protein 1C
H2866_RS02735	COG2373	Large extracellular alpha-helical protein
H2866_RS02750	COG2423	ornithine cyclodeaminase activity
H2866_RS02765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H2866_RS02770	COG1104	cysteine desulfurase activity
H2866_RS02775	COG1959	2 iron, 2 sulfur cluster binding
H2866_RS02780	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H2866_RS02795	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H2866_RS02800	COG3683	transport system, periplasmic component
H2866_RS02805	COG3711	transcriptional antiterminator
H2866_RS02810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H2866_RS02815	COG1017	nitric oxide dioxygenase activity
H2866_RS02815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2866_RS02820	COG0347	Belongs to the P(II) protein family
H2866_RS02825	COG2204	response regulator
H2866_RS02830	COG3170	Tfp pilus assembly protein FimV
H2866_RS02835	COG2205	protein histidine kinase activity
H2866_RS02865	COG0583	DNA-binding transcription factor activity
H2866_RS02870	COG1280	lysine exporter protein (LysE YggA)
H2866_RS02880	COG2223	nitrite transmembrane transporter activity
H2866_RS02890	COG0814	amino acid
H2866_RS02895	COG1760	l-serine dehydratase
H2866_RS02960	COG0745	RESPONSE REGULATOR receiver
H2866_RS02970	COG1278	Cold shock
H2866_RS02990	COG2197	response regulator
H2866_RS02995	COG2205	protein histidine kinase activity
H2866_RS02995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS03000	COG2814	Major facilitator Superfamily
H2866_RS03010	COG0583	DNA-binding transcription factor activity
H2866_RS03030	COG0534	Mate efflux family protein
H2866_RS03035	COG3011	Protein conserved in bacteria
H2866_RS03040	COG1764	response to oxidative stress
H2866_RS03050	COG3781	membrane
H2866_RS03055	COG2814	Major facilitator Superfamily
H2866_RS03060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2866_RS03075	COG3718	enzyme involved in inositol metabolism
H2866_RS03100	COG2814	Major facilitator Superfamily
H2866_RS03105	COG1082	Xylose isomerase domain protein TIM barrel
H2866_RS03110	COG0673	inositol 2-dehydrogenase activity
H2866_RS03135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H2866_RS03140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2866_RS03140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2866_RS03140	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H2866_RS03165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2866_RS03185	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2866_RS03190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2866_RS03195	COG3034	peptidoglycan biosynthetic process
H2866_RS03200	COG0121	glutamine amidotransferase
H2866_RS03210	COG1960	acyl-CoA dehydrogenase activity
H2866_RS03215	COG4807	Protein conserved in bacteria
H2866_RS03220	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H2866_RS03225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H2866_RS03230	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H2866_RS03235	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H2866_RS03240	COG0235	Class ii aldolase
H2866_RS03245	COG0436	Aminotransferase
H2866_RS03255	COG0504	CTP synthase activity
H2866_RS03260	COG2233	PERMEase
H2866_RS03265	COG2351	hydroxyisourate hydrolase activity
H2866_RS03280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H2866_RS03290	COG0765	amino acid transport
H2866_RS03340	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2866_RS03345	COG1486	melibiose metabolic process
H2866_RS03350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2866_RS03370	COG1953	Uracil, thiamine, allantoin
H2866_RS03390	COG2226	methyltransferase
H2866_RS03395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2866_RS03400	COG0741	lytic transglycosylase activity
H2866_RS03400	COG1388	LysM domain
H2866_RS03405	COG4974	Belongs to the 'phage' integrase family
H2866_RS03430	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H2866_RS03445	COG0210	DNA helicase
H2866_RS03455	COG4695	Portal protein
H2866_RS03600	COG2814	Major facilitator Superfamily
H2866_RS03605	COG3021	interspecies interaction between organisms
H2866_RS03610	COG0583	DNA-binding transcription factor activity
H2866_RS03615	COG0656	L-ascorbic acid biosynthetic process
H2866_RS03625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2866_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS03640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2866_RS03665	COG0463	Glycosyl transferase, family 2
H2866_RS03685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2866_RS03735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H2866_RS03740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2866_RS03745	COG2011	ABC-type metal ion transport system permease component
H2866_RS03760	COG1720	tRNA m6t6A37 methyltransferase activity
H2866_RS03765	COG0442	prolyl-tRNA aminoacylation
H2866_RS03770	COG3015	lipoprotein NlpE involved in copper resistance
H2866_RS03775	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H2866_RS03790	COG4568	rho-dependent transcription termination
H2866_RS03800	COG0037	tRNA processing
H2866_RS03805	COG0346	lactoylglutathione lyase activity
H2866_RS03810	COG1982	Orn Lys Arg decarboxylase major
H2866_RS03815	COG0825	malonyl-CoA metabolic process
H2866_RS03825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2866_RS03835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2866_RS03840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H2866_RS03845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2866_RS03850	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H2866_RS03855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2866_RS03860	COG0750	zinc metalloprotease
H2866_RS03865	COG0575	Belongs to the CDS family
H2866_RS03870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2866_RS03880	COG0233	cytoplasmic translational termination
H2866_RS03885	COG0528	UMP kinase activity
H2866_RS03890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H2866_RS03895	COG0052	Belongs to the universal ribosomal protein uS2 family
H2866_RS03905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H2866_RS03925	COG0564	pseudouridine synthase activity
H2866_RS03930	COG3098	single-species biofilm formation
H2866_RS03935	COG2814	Major facilitator Superfamily
H2866_RS03950	COG1611	Belongs to the LOG family
H2866_RS03965	COG2363	Small membrane protein
H2866_RS03970	COG0583	DNA-binding transcription factor activity
H2866_RS03980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2866_RS03985	COG2166	iron-sulfur cluster assembly
H2866_RS03990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2866_RS03995	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H2866_RS04015	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2866_RS04020	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2866_RS04020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2866_RS04025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2866_RS04030	COG1074	ATP-dependent DNA helicase activity
H2866_RS04035	COG1025	Belongs to the peptidase M16 family
H2866_RS04040	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H2866_RS04045	COG4967	type IV pilus modification protein PilV
H2866_RS04055	COG4795	General secretion pathway protein
H2866_RS04065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H2866_RS04070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H2866_RS04080	COG0494	nUDIX hydrolase
H2866_RS04085	COG3066	DNA modification
H2866_RS04095	COG0667	Aldo Keto reductase
H2866_RS04115	COG1609	Transcriptional regulator
H2866_RS04125	COG2186	Transcriptional regulator
H2866_RS04130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2866_RS04135	COG2723	6-phospho-beta-galactosidase activity
H2866_RS04140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2866_RS04145	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2866_RS04155	COG0583	DNA-binding transcription factor activity
H2866_RS04175	COG4178	(ABC) transporter
H2866_RS04195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2866_RS04195	COG1263	PTS System
H2866_RS04225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2866_RS04230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2866_RS04235	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS04250	COG1725	Transcriptional regulator
H2866_RS04260	COG0601	transmembrane transport
H2866_RS04265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS04275	COG4608	Belongs to the ABC transporter superfamily
H2866_RS04285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H2866_RS04310	COG4774	siderophore transport
H2866_RS04315	COG0700	Nucleoside recognition
H2866_RS04320	COG3366	ferrous iron transmembrane transporter activity
H2866_RS04325	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2866_RS04330	COG0583	DNA-binding transcription factor activity
H2866_RS04335	COG3037	sugar-specific permease SgaT UlaA
H2866_RS04345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2866_RS04350	COG1609	Transcriptional regulator
H2866_RS04360	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H2866_RS04365	COG0625	glutathione transferase activity
H2866_RS04400	COG2353	YceI-like domain
H2866_RS04440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H2866_RS04450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2866_RS04455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2866_RS04460	COG4974	Belongs to the 'phage' integrase family
H2866_RS04465	COG0716	FMN binding
H2866_RS04475	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H2866_RS04490	COG1272	protein, Hemolysin III
H2866_RS04510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2866_RS04515	COG0395	ABC-type sugar transport system, permease component
H2866_RS04520	COG1175	transmembrane transport
H2866_RS04525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2866_RS04530	COG1940	carbohydrate kinase activity
H2866_RS04535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2866_RS04540	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS04545	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS04550	COG1129	ABC transporter
H2866_RS04560	COG1349	DNA-binding transcription factor activity
H2866_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS04595	COG1605	Chorismate mutase
H2866_RS04605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2866_RS04605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2866_RS04610	COG0509	glycine decarboxylation via glycine cleavage system
H2866_RS04615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H2866_RS04620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2866_RS04625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2866_RS04630	COG0006	proline dipeptidase activity
H2866_RS04640	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H2866_RS04650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2866_RS04660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2866_RS04665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H2866_RS04670	COG0583	DNA-binding transcription factor activity
H2866_RS04680	COG1279	arginine transmembrane transporter activity
H2866_RS04685	COG0668	transmembrane transport
H2866_RS04690	COG2223	nitrite transmembrane transporter activity
H2866_RS04700	COG1609	Transcriptional regulator
H2866_RS04705	COG1113	amino acid transport
H2866_RS04715	COG0191	fructose-bisphosphate aldolase activity
H2866_RS04720	COG0126	phosphoglycerate kinase activity
H2866_RS04725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2866_RS04730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2866_RS04735	COG0010	Belongs to the arginase family
H2866_RS04740	COG1166	arginine decarboxylase activity
H2866_RS04745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H2866_RS04750	COG2814	Major facilitator Superfamily
H2866_RS04755	COG3091	SprT-like family
H2866_RS04760	COG2356	endonuclease I
H2866_RS04765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2866_RS04770	COG0189	ligase activity
H2866_RS04775	COG1678	Uncharacterized ACR, COG1678
H2866_RS04780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2866_RS04785	COG2805	Type II/IV secretion system protein
H2866_RS04790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H2866_RS04795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H2866_RS04800	COG0762	integral membrane protein
H2866_RS04805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H2866_RS04810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2866_RS04820	COG2066	Belongs to the glutaminase family
H2866_RS04825	COG3171	Protein conserved in bacteria
H2866_RS04830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2866_RS04835	COG1194	a g-specific adenine glycosylase
H2866_RS04840	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H2866_RS04855	COG1982	Orn Lys Arg decarboxylase major
H2866_RS04865	COG4221	oxidoreductase activity
H2866_RS04880	COG1902	pentaerythritol trinitrate reductase activity
H2866_RS04885	COG1942	4-Oxalocrotonate Tautomerase
H2866_RS04890	COG1609	Transcriptional regulator
H2866_RS04910	COG2211	Major facilitator Superfamily
H2866_RS04925	COG4993	Dehydrogenase
H2866_RS04930	COG1414	Transcriptional regulator
H2866_RS04935	COG1129	ABC transporter
H2866_RS04940	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS04960	COG1879	ABC-type sugar transport system periplasmic component
H2866_RS04965	COG1129	ABC transporter
H2866_RS04970	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS04975	COG1737	Transcriptional regulator
H2866_RS04980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2866_RS04985	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2866_RS04995	COG1653	transport
H2866_RS05005	COG0395	ABC-type sugar transport system, permease component
H2866_RS05010	COG3842	ATPase activity
H2866_RS05025	COG1349	DNA-binding transcription factor activity
H2866_RS05035	COG2222	sugar isomerase
H2866_RS05045	COG0322	excinuclease ABC activity
H2866_RS05050	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS05060	COG1396	sequence-specific DNA binding
H2866_RS05080	COG0583	DNA-binding transcription factor activity
H2866_RS05100	COG2207	Transcriptional regulator
H2866_RS05100	COG3708	Transcriptional regulator
H2866_RS05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2866_RS05120	COG2252	PERMEase
H2866_RS05140	COG0583	DNA-binding transcription factor activity
H2866_RS05145	COG0477	Major facilitator Superfamily
H2866_RS05165	COG0583	DNA-binding transcription factor activity
H2866_RS05170	COG2851	Citrate transporter
H2866_RS05180	COG3145	DNA-N1-methyladenine dioxygenase activity
H2866_RS05185	COG0848	biopolymer transport protein
H2866_RS05205	COG2207	Transcriptional regulator
H2866_RS05210	COG0656	L-ascorbic acid biosynthetic process
H2866_RS05215	COG2132	Multicopper oxidase
H2866_RS05220	COG0204	Acyl-transferase
H2866_RS05230	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2866_RS05235	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2866_RS05240	COG0187	DNA topoisomerase II activity
H2866_RS05245	COG3150	esterase
H2866_RS05250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2866_RS05255	COG3151	Protein conserved in bacteria
H2866_RS05260	COG0494	nUDIX hydrolase
H2866_RS05265	COG1538	Outer membrane efflux protein
H2866_RS05270	COG5463	Belongs to the UPF0441 family
H2866_RS05275	COG0754	glutathionylspermidine amidase activity
H2866_RS05280	COG3384	dioxygenase
H2866_RS05285	COG2194	sulfuric ester hydrolase activity
H2866_RS05290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H2866_RS05295	COG2960	long-chain fatty acid transporting porin activity
H2866_RS05300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H2866_RS05300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H2866_RS05310	COG3025	triphosphatase activity
H2866_RS05315	COG4991	sh3 domain protein
H2866_RS05325	COG1968	undecaprenyl-diphosphatase activity
H2866_RS05330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H2866_RS05335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H2866_RS05340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H2866_RS05345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H2866_RS05350	COG0358	DNA primase activity
H2866_RS05360	COG3663	DNA glycosylase
H2866_RS05460	COG3318	Belongs to the UPF0149 family
H2866_RS05460	COG3012	SEC-C Motif Domain Protein
H2866_RS05495	COG0463	Glycosyl transferase, family 2
H2866_RS05500	COG1215	transferase activity, transferring glycosyl groups
H2866_RS05505	COG1216	Glycosyl transferase, family 2
H2866_RS05520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2866_RS05545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2866_RS05555	COG4566	intracellular signal transduction
H2866_RS05570	COG1902	pentaerythritol trinitrate reductase activity
H2866_RS05570	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2866_RS05575	COG2813	Specifically methylates the guanine in position
H2866_RS05580	COG1451	nucleotide metabolic process
H2866_RS05585	COG0673	inositol 2-dehydrogenase activity
H2866_RS05590	COG0519	Catalyzes the synthesis of GMP from XMP
H2866_RS05590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2866_RS05595	COG0861	Integral membrane protein TerC family
H2866_RS05625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2866_RS05630	COG1328	CTP reductase activity
H2866_RS05635	COG0602	queuosine metabolic process
H2866_RS05640	COG2188	Transcriptional regulator
H2866_RS05645	COG3624	Phosphonate C-P lyase system protein PhnG
H2866_RS05650	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H2866_RS05655	COG3626	phosphonate metabolism
H2866_RS05660	COG3627	carbon phosphorus lyase activity
H2866_RS05665	COG4107	phosphonate C-P lyase system protein PhnK
H2866_RS05670	COG4778	phosphonate C-P lyase system protein PhnL
H2866_RS05675	COG3454	Phosphonate metabolism
H2866_RS05680	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H2866_RS05695	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2866_RS05705	COG0583	DNA-binding transcription factor activity
H2866_RS05710	COG3787	Belongs to the UPF0306 family
H2866_RS05715	COG2827	Endonuclease containing a URI domain
H2866_RS05725	COG3153	acetyltransferase
H2866_RS05730	COG3154	lipid carrier protein
H2866_RS05735	COG0826	peptidase U32
H2866_RS05740	COG0826	peptidase U32
H2866_RS05750	COG0842	Transport permease protein
H2866_RS05760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS05765	COG0513	Belongs to the DEAD box helicase family
H2866_RS05780	COG1185	polyribonucleotide nucleotidyltransferase activity
H2866_RS05785	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H2866_RS05790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2866_RS05795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H2866_RS05800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H2866_RS05805	COG0195	Participates in both transcription termination and antitermination
H2866_RS05810	COG0779	Required for maturation of 30S ribosomal subunits
H2866_RS05825	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H2866_RS05830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2866_RS05835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2866_RS05845	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H2866_RS05850	COG1534	Rna-binding protein
H2866_RS05860	COG2027	D-alanyl-D-alanine carboxypeptidase
H2866_RS05865	COG0745	RESPONSE REGULATOR receiver
H2866_RS05870	COG0642	Histidine kinase
H2866_RS05875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H2866_RS05880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H2866_RS05885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H2866_RS05890	COG0142	geranyltranstransferase activity
H2866_RS05905	COG3423	Transcriptional regulator
H2866_RS05910	COG0039	L-malate dehydrogenase activity
H2866_RS05915	COG1438	arginine binding
H2866_RS05925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2866_RS05930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H2866_RS05940	COG2105	PFAM AIG2 family protein
H2866_RS05945	COG2911	Protein conserved in bacteria
H2866_RS05950	COG0729	surface antigen
H2866_RS05955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2866_RS05960	COG1253	flavin adenine dinucleotide binding
H2866_RS05970	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H2866_RS05980	COG0737	Belongs to the 5'-nucleotidase family
H2866_RS05985	COG0545	Peptidyl-prolyl cis-trans isomerase
H2866_RS05990	COG3061	Opacity-associated protein A
H2866_RS05995	COG0359	binds to the 23S rRNA
H2866_RS06000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H2866_RS06010	COG0360	Binds together with S18 to 16S ribosomal RNA
H2866_RS06015	COG1073	alpha beta
H2866_RS06025	COG1960	acyl-CoA dehydrogenase activity
H2866_RS06030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2866_RS06035	COG0557	exoribonuclease II activity
H2866_RS06045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2866_RS06050	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H2866_RS06055	COG0330	HflC and HflK could
H2866_RS06060	COG0330	HflC and HflK could
H2866_RS06065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2866_RS06075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H2866_RS06080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2866_RS06085	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2866_RS06090	COG0802	atpase or kinase
H2866_RS06095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2866_RS06095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H2866_RS06100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2866_RS06120	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H2866_RS06125	COG1162	GTPase activity
H2866_RS06135	COG1511	domain protein
H2866_RS06135	COG3264	Mechanosensitive ion channel
H2866_RS06145	COG2233	PERMEase
H2866_RS06150	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H2866_RS06155	COG3040	lipid binding
H2866_RS06160	COG5510	response to toxic substance
H2866_RS06170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2866_RS06190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H2866_RS06205	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H2866_RS06210	COG4232	protein-disulfide reductase activity
H2866_RS06215	COG1309	transcriptional regulator
H2866_RS06230	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS06235	COG1535	isochorismatase
H2866_RS06235	COG3433	isochorismatase activity
H2866_RS06240	COG1021	2,3-dihydroxybenzoate-AMP ligase
H2866_RS06245	COG1169	isochorismate synthase
H2866_RS06250	COG4592	Periplasmic binding protein
H2866_RS06260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2866_RS06265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2866_RS06270	COG1120	ATPase activity
H2866_RS06275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2866_RS06275	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H2866_RS06285	COG2382	esterase
H2866_RS06295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H2866_RS06300	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H2866_RS06305	COG0745	RESPONSE REGULATOR receiver
H2866_RS06310	COG5002	protein histidine kinase activity
H2866_RS06320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2866_RS06325	COG3162	membrane
H2866_RS06330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2866_RS06365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H2866_RS06370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H2866_RS06375	COG0009	L-threonylcarbamoyladenylate synthase
H2866_RS06380	COG0551	DNA topoisomerase type I activity
H2866_RS06385	COG2922	Belongs to the Smg family
H2866_RS06390	COG0758	DNA mediated transformation
H2866_RS06395	COG0242	peptide deformylase activity
H2866_RS06400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H2866_RS06405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H2866_RS06405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H2866_RS06420	COG3036	rescue of stalled ribosome
H2866_RS06425	COG0789	Transcriptional regulator
H2866_RS06435	COG0203	ribosomal protein L17
H2866_RS06440	COG0202	RNA polymerase activity
H2866_RS06450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H2866_RS06455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H2866_RS06460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H2866_RS06465	COG0201	protein transport
H2866_RS06475	COG1841	ribosomal large subunit assembly
H2866_RS06485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H2866_RS06490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H2866_RS06495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H2866_RS06500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H2866_RS06505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H2866_RS06515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H2866_RS06530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H2866_RS06535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H2866_RS06540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H2866_RS06545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H2866_RS06555	COG0089	rRNA binding
H2866_RS06560	COG0088	Forms part of the polypeptide exit tunnel
H2866_RS06565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H2866_RS06570	COG0051	transcription antitermination factor activity, RNA binding
H2866_RS06575	COG2193	ferroxidase activity
H2866_RS06585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2866_RS06590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H2866_RS06595	COG0049	tRNA binding
H2866_RS06600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H2866_RS06605	COG2168	tRNA wobble position uridine thiolation
H2866_RS06610	COG2923	Belongs to the DsrF TusC family
H2866_RS06615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H2866_RS06620	COG2964	Protein conserved in bacteria
H2866_RS06625	COG0545	Peptidyl-prolyl cis-trans isomerase
H2866_RS06635	COG1047	Peptidyl-prolyl cis-trans
H2866_RS06640	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H2866_RS06650	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2866_RS06655	COG0488	(ABC) transporter
H2866_RS06660	COG2175	clavaminate synthase activity
H2866_RS06665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2866_RS06675	COG4521	taurine ABC transporter
H2866_RS06685	COG0429	hydrolase of the alpha beta-hydrolase fold
H2866_RS06690	COG3089	Belongs to the UPF0270 family
H2866_RS06695	COG3954	Phosphoribulokinase
H2866_RS06710	COG0583	DNA-binding transcription factor activity
H2866_RS06715	COG1765	OsmC-like protein
H2866_RS06720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2866_RS06725	COG1289	transmembrane transporter activity
H2866_RS06750	COG0433	COG0433 Predicted ATPase
H2866_RS06755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2866_RS06760	COG0402	S-adenosylhomocysteine deaminase activity
H2866_RS06765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2866_RS06780	COG0180	Tryptophanyl-tRNA synthetase
H2866_RS06785	COG0546	phosphoglycolate phosphatase activity
H2866_RS06790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2866_RS06805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H2866_RS06810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H2866_RS06815	COG4796	Type ii and iii secretion system protein
H2866_RS06835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H2866_RS06840	COG0494	nUDIX hydrolase
H2866_RS06850	COG1011	Hydrolase
H2866_RS06855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2866_RS06860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H2866_RS06890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2866_RS06895	COG2183	response to ionizing radiation
H2866_RS06900	COG1918	ferrous iron import across plasma membrane
H2866_RS06905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H2866_RS06915	COG2267	carboxylic ester hydrolase activity
H2866_RS06925	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H2866_RS06925	COG0316	Belongs to the HesB IscA family
H2866_RS06930	COG1640	4-alpha-glucanotransferase
H2866_RS06935	COG0058	SHG alpha-glucan phosphorylase activity
H2866_RS06940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2866_RS06945	COG2271	Major facilitator Superfamily
H2866_RS06950	COG2731	YhcH YjgK YiaL family protein
H2866_RS06955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2866_RS06965	COG0705	Rhomboid family
H2866_RS06970	COG1349	DNA-binding transcription factor activity
H2866_RS06975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H2866_RS06980	COG0058	SHG alpha-glucan phosphorylase activity
H2866_RS06985	COG0297	glycogen (starch) synthase activity
H2866_RS06990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H2866_RS06995	COG1523	belongs to the glycosyl hydrolase 13 family
H2866_RS07000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H2866_RS07005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H2866_RS07010	COG2095	MarC family integral membrane protein
H2866_RS07020	COG0235	Class ii aldolase
H2866_RS07050	COG1012	belongs to the aldehyde dehydrogenase family
H2866_RS07060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H2866_RS07065	COG2610	gluconate transmembrane transporter activity
H2866_RS07070	COG3265	gluconokinase activity
H2866_RS07075	COG1609	Transcriptional regulator
H2866_RS07080	COG1741	Belongs to the pirin family
H2866_RS07085	COG1247	-acetyltransferase
H2866_RS07105	COG0583	DNA-binding transcription factor activity
H2866_RS07115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2866_RS07120	COG2423	ornithine cyclodeaminase activity
H2866_RS07140	COG0583	DNA-binding transcription factor activity
H2866_RS07150	COG0561	phosphatase activity
H2866_RS07160	COG3037	sugar-specific permease SgaT UlaA
H2866_RS07170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2866_RS07185	COG2390	Transcriptional regulator
H2866_RS07190	COG2081	HI0933 family
H2866_RS07195	COG0306	phosphate transporter
H2866_RS07205	COG0589	response to stress
H2866_RS07215	COG0742	ribosomal rna small subunit methyltransferase
H2866_RS07225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H2866_RS07230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2866_RS07250	COG0583	DNA-binding transcription factor activity
H2866_RS07255	COG1741	Belongs to the pirin family
H2866_RS07285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H2866_RS07290	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H2866_RS07310	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2866_RS07315	COG2271	Major facilitator Superfamily
H2866_RS07325	COG1132	(ABC) transporter
H2866_RS07330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H2866_RS07340	COG1953	Uracil, thiamine, allantoin
H2866_RS07345	COG2186	Transcriptional regulator
H2866_RS07355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H2866_RS07360	COG0579	oxidoreductase
H2866_RS07390	COG3038	cytochrome b561
H2866_RS07405	COG0583	DNA-binding transcription factor activity
H2866_RS07410	COG1295	ribonuclease BN
H2866_RS07415	COG0477	Major facilitator Superfamily
H2866_RS07425	COG2982	Protein involved in outer membrane biogenesis
H2866_RS07430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2866_RS07435	COG0612	Peptidase, M16
H2866_RS07440	COG1301	dicarboxylic acid transport
H2866_RS07445	COG2200	EAL domain
H2866_RS07445	COG2199	diguanylate cyclase activity
H2866_RS07450	COG4608	Belongs to the ABC transporter superfamily
H2866_RS07455	COG0444	Belongs to the ABC transporter superfamily
H2866_RS07460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS07465	COG0601	transmembrane transport
H2866_RS07470	COG0747	negative chemotaxis
H2866_RS07475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2866_RS07480	COG0583	DNA-binding transcription factor activity
H2866_RS07495	COG2194	sulfuric ester hydrolase activity
H2866_RS07500	COG1764	response to oxidative stress
H2866_RS07505	COG1846	Transcriptional regulator
H2866_RS07525	COG1802	Transcriptional regulator
H2866_RS07545	COG1129	ABC transporter
H2866_RS07555	COG2261	transglycosylase associated protein
H2866_RS07565	COG1280	lysine exporter protein (LysE YggA)
H2866_RS07575	COG0625	glutathione transferase activity
H2866_RS07590	COG3135	benzoate transporter
H2866_RS07595	COG1063	alcohol dehydrogenase
H2866_RS07600	COG1335	isochorismatase
H2866_RS07610	COG3274	enterobacterial common antigen metabolic process
H2866_RS07620	COG0625	glutathione transferase activity
H2866_RS07640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2866_RS07655	COG3722	fumarate hydratase activity
H2866_RS07660	COG0246	Mannitol dehydrogenase
H2866_RS07665	COG2213	PTS system mannitol-specific
H2866_RS07665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2866_RS07680	COG0710	3-dehydroquinate dehydratase activity
H2866_RS07685	COG2807	transmembrane transport
H2866_RS07695	COG0583	DNA-binding transcription factor activity
H2866_RS07725	COG1116	anion transmembrane transporter activity
H2866_RS07740	COG0439	Biotin carboxylase
H2866_RS07755	COG4977	sequence-specific DNA binding
H2866_RS07760	COG0626	cystathionine gamma-synthase activity
H2866_RS07765	COG0751	glycine-tRNA ligase activity
H2866_RS07780	COG2271	Major facilitator Superfamily
H2866_RS07785	COG2818	Glycosylase
H2866_RS07795	COG2885	chlorophyll binding
H2866_RS07800	COG1609	Transcriptional regulator
H2866_RS07810	COG2271	Major facilitator Superfamily
H2866_RS07815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2866_RS07820	COG3977	Valine--pyruvate aminotransferase
H2866_RS07825	COG0071	Belongs to the small heat shock protein (HSP20) family
H2866_RS07835	COG5645	(Lipo)protein
H2866_RS07840	COG0823	Involved in the tonB-independent uptake of proteins
H2866_RS07845	COG0561	phosphatase activity
H2866_RS07855	COG0187	DNA topoisomerase II activity
H2866_RS07860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H2866_RS07865	COG0592	DNA-directed DNA polymerase activity
H2866_RS07875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H2866_RS07890	COG0706	membrane insertase activity
H2866_RS07905	COG2091	lysine biosynthetic process via aminoadipic acid
H2866_RS07910	COG0431	NADPH-dependent FMN reductase
H2866_RS07915	COG2252	PERMEase
H2866_RS07920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2866_RS07930	COG0704	Plays a role in the regulation of phosphate uptake
H2866_RS07940	COG0581	inorganic phosphate transmembrane transporter activity
H2866_RS07945	COG0573	inorganic phosphate transmembrane transporter activity
H2866_RS07950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2866_RS07955	COG1187	pseudouridine synthase activity
H2866_RS07970	COG1595	DNA-templated transcription, initiation
H2866_RS07980	COG0438	transferase activity, transferring glycosyl groups
H2866_RS07980	COG4641	Protein conserved in bacteria
H2866_RS07995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H2866_RS08000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H2866_RS08005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H2866_RS08010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H2866_RS08015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2866_RS08030	COG0356	it plays a direct role in the translocation of protons across the membrane
H2866_RS08035	COG3312	ion transport
H2866_RS08040	COG0357	Ribosomal RNA small subunit methyltransferase G
H2866_RS08045	COG0445	tRNA wobble uridine modification
H2866_RS08050	COG0716	FMN binding
H2866_RS08055	COG1522	sequence-specific DNA binding
H2866_RS08060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H2866_RS08075	COG1869	D-ribose catabolic process
H2866_RS08080	COG1129	ABC transporter
H2866_RS08085	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS08095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2866_RS08100	COG1609	Transcriptional regulator
H2866_RS08105	COG2186	Transcriptional regulator
H2866_RS08130	COG1763	Mo-molybdopterin cofactor biosynthetic process
H2866_RS08135	COG0746	molybdenum cofactor guanylyltransferase activity
H2866_RS08140	COG3084	Protein conserved in bacteria
H2866_RS08145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2866_RS08160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H2866_RS08165	COG3078	GTPase activator activity
H2866_RS08195	COG1459	type II secretion system
H2866_RS08200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2866_RS08225	COG4796	Type ii and iii secretion system protein
H2866_RS08250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2866_RS08260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2866_RS08265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2866_RS08270	COG0583	DNA-binding transcription factor activity
H2866_RS08275	COG2259	Doxx family
H2866_RS08290	COG0861	Integral membrane protein TerC family
H2866_RS08295	COG2851	Citrate transporter
H2866_RS08305	COG3852	Histidine kinase
H2866_RS08310	COG0174	glutamine synthetase
H2866_RS08320	COG1011	Hydrolase
H2866_RS08325	COG1295	ribonuclease BN
H2866_RS08330	COG1490	D-aminoacyl-tRNA deacylase activity
H2866_RS08335	COG0456	acetyltransferase
H2866_RS08340	COG2982	Protein involved in outer membrane biogenesis
H2866_RS08345	COG2233	PERMEase
H2866_RS08350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H2866_RS08355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2866_RS08360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2866_RS08365	COG1758	RNA polymerase activity
H2866_RS08370	COG0194	GDP metabolic process
H2866_RS08380	COG2860	membrane
H2866_RS08390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2866_RS08400	COG1561	YicC-like family, N-terminal region
H2866_RS08405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H2866_RS08410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H2866_RS08415	COG1309	transcriptional regulator
H2866_RS08420	COG0756	dUTP diphosphatase activity
H2866_RS08425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2866_RS08430	COG2003	Belongs to the UPF0758 family
H2866_RS08435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H2866_RS08440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H2866_RS08445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2866_RS08450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H2866_RS08460	COG1519	Transferase
H2866_RS08465	COG0438	transferase activity, transferring glycosyl groups
H2866_RS08475	COG0859	PFAM glycosyl transferase family 9
H2866_RS08485	COG0859	PFAM glycosyl transferase family 9
H2866_RS08495	COG0859	PFAM glycosyl transferase family 9
H2866_RS08500	COG0859	PFAM glycosyl transferase family 9
H2866_RS08505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2866_RS08515	COG1063	alcohol dehydrogenase
H2866_RS08520	COG2861	carbohydrate metabolic process
H2866_RS08525	COG4942	peptidase
H2866_RS08530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2866_RS08535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2866_RS08540	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H2866_RS08545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H2866_RS08550	COG1045	serine acetyltransferase
H2866_RS08555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2866_RS08560	COG2205	protein histidine kinase activity
H2866_RS08565	COG0745	RESPONSE REGULATOR receiver
H2866_RS08570	COG3678	ATP-independent chaperone mediated protein folding
H2866_RS08580	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H2866_RS08585	COG0149	triose-phosphate isomerase activity
H2866_RS08600	COG1494	fructose-1,6-bisphosphatase
H2866_RS08610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2866_RS08615	COG3074	FtsZ-dependent cytokinesis
H2866_RS08620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2866_RS08625	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H2866_RS08630	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H2866_RS08635	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H2866_RS08640	COG1609	Transcriptional regulator
H2866_RS08645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2866_RS08650	COG0254	rRNA binding
H2866_RS08655	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
H2866_RS08660	COG0626	cystathionine gamma-synthase activity
H2866_RS08665	COG0460	homoserine dehydrogenase
H2866_RS08665	COG0527	aspartate kinase activity
H2866_RS08670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H2866_RS08680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2866_RS08685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H2866_RS08690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2866_RS08695	COG0137	argininosuccinate synthase activity
H2866_RS08700	COG0165	Argininosuccinate lyase
H2866_RS08705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2866_RS08705	COG0678	peroxiredoxin activity
H2866_RS08715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2866_RS08730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2866_RS08735	COG4206	TonB-dependent receptor
H2866_RS08740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2866_RS08780	COG1879	ABC-type sugar transport system periplasmic component
H2866_RS08785	COG1129	ABC transporter
H2866_RS08790	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS08795	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS08800	COG0583	DNA-binding transcription factor activity
H2866_RS08805	COG3085	chromosome segregation
H2866_RS08810	COG0606	chelatase, subunit chli
H2866_RS08815	COG2814	Major facilitator Superfamily
H2866_RS08830	COG3978	acetolactate synthase activity
H2866_RS08835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2866_RS08840	COG0129	dihydroxy-acid dehydratase activity
H2866_RS08845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2866_RS08860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H2866_RS08865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2866_RS08875	COG0248	Ppx GppA phosphatase
H2866_RS08885	COG3118	belongs to the thioredoxin family
H2866_RS08890	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H2866_RS08895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2866_RS08900	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H2866_RS08905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H2866_RS08910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H2866_RS08915	COG0456	acetyltransferase
H2866_RS08920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2866_RS08925	COG2244	polysaccharide biosynthetic process
H2866_RS08930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2866_RS08940	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H2866_RS08970	COG1472	Belongs to the glycosyl hydrolase 3 family
H2866_RS08975	COG3071	HemY protein
H2866_RS08980	COG2959	enzyme of heme biosynthesis
H2866_RS08985	COG1587	Uroporphyrinogen-III synthase
H2866_RS08990	COG0181	hydroxymethylbilane synthase activity
H2866_RS08995	COG3072	Adenylate cyclase
H2866_RS09000	COG5567	small periplasmic lipoprotein
H2866_RS09005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H2866_RS09020	COG1011	Hydrolase
H2866_RS09025	COG0210	DNA helicase
H2866_RS09040	COG3180	Ammonia monooxygenase
H2866_RS09050	COG2050	protein possibly involved in aromatic compounds catabolism
H2866_RS09060	COG0514	ATP-dependent DNA helicase (RecQ)
H2866_RS09065	COG1280	lysine exporter protein (LysE YggA)
H2866_RS09070	COG1280	lysine exporter protein (LysE YggA)
H2866_RS09075	COG2267	carboxylic ester hydrolase activity
H2866_RS09080	COG0561	phosphatase activity
H2866_RS09090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H2866_RS09095	COG0425	Belongs to the sulfur carrier protein TusA family
H2866_RS09100	COG2217	Heavy metal translocating P-type atpase
H2866_RS09105	COG3714	YhhN family
H2866_RS09110	COG3776	membrane
H2866_RS09115	COG0742	ribosomal rna small subunit methyltransferase
H2866_RS09120	COG0552	protein localization to endoplasmic reticulum
H2866_RS09125	COG2884	Cell division ATP-binding protein ftsE
H2866_RS09130	COG2177	Part of the ABC transporter FtsEX involved in
H2866_RS09155	COG4177	L-phenylalanine transmembrane transporter activity
H2866_RS09170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2866_RS09175	COG1653	transport
H2866_RS09180	COG1175	transmembrane transport
H2866_RS09185	COG0395	ABC-type sugar transport system, permease component
H2866_RS09195	COG0584	glycerophosphoryl diester phosphodiesterase
H2866_RS09215	COG0583	DNA-binding transcription factor activity
H2866_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS09230	COG0412	Dienelactone hydrolase
H2866_RS09245	COG0586	Pfam SNARE associated Golgi protein
H2866_RS09250	COG1322	Protein conserved in bacteria
H2866_RS09260	COG3165	ubiquinone biosynthetic process from chorismate
H2866_RS09265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H2866_RS09280	COG0805	protein transport
H2866_RS09285	COG0084	hydrolase, TatD family'
H2866_RS09300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2866_RS09310	COG0183	Belongs to the thiolase family
H2866_RS09315	COG1024	Enoyl-CoA hydratase
H2866_RS09315	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2866_RS09320	COG0006	proline dipeptidase activity
H2866_RS09325	COG1739	Uncharacterized protein family UPF0029
H2866_RS09330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2866_RS09360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H2866_RS09370	COG1072	(Pantothenic acid kinase))
H2866_RS09400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2866_RS09410	COG0250	Participates in transcription elongation, termination and antitermination
H2866_RS09425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H2866_RS09430	COG0222	ribosome binding
H2866_RS09435	COG0085	RNA polymerase activity
H2866_RS09440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H2866_RS09450	COG2022	thiamine diphosphate biosynthetic process
H2866_RS09455	COG2104	thiamine diphosphate biosynthetic process
H2866_RS09460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2866_RS09465	COG0352	thiamine-phosphate diphosphorylase activity
H2866_RS09470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H2866_RS09475	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H2866_RS09485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H2866_RS09490	COG1515	deoxyribonuclease V activity
H2866_RS09510	COG0151	Belongs to the GarS family
H2866_RS09545	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H2866_RS09550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H2866_RS09560	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H2866_RS09570	COG0646	methionine synthase
H2866_RS09570	COG1410	methionine synthase
H2866_RS09590	COG0395	ABC-type sugar transport system, permease component
H2866_RS09600	COG3842	ATPase activity
H2866_RS09620	COG0527	aspartate kinase activity
H2866_RS09625	COG0166	Belongs to the GPI family
H2866_RS09630	COG3223	Belongs to the PsiE family
H2866_RS09645	COG2937	Belongs to the GPAT DAPAT family
H2866_RS09650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H2866_RS09655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2866_RS09660	COG0534	Mate efflux family protein
H2866_RS09665	COG3237	CsbD-like
H2866_RS09675	COG0735	belongs to the Fur family
H2866_RS09680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2866_RS09725	COG0604	alcohol dehydrogenase
H2866_RS09730	COG1309	transcriptional regulator
H2866_RS09740	COG2315	Protein conserved in bacteria
H2866_RS09750	COG0625	glutathione transferase activity
H2866_RS09755	COG0583	DNA-binding transcription factor activity
H2866_RS09760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H2866_RS09770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H2866_RS09800	COG0583	DNA-binding transcription factor activity
H2866_RS09805	COG0697	spore germination
H2866_RS09815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2866_RS09820	COG0625	glutathione transferase activity
H2866_RS09845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2866_RS09855	COG0584	glycerophosphoryl diester phosphodiesterase
H2866_RS09860	COG0483	inositol monophosphate 1-phosphatase activity
H2866_RS09875	COG2252	PERMEase
H2866_RS09880	COG0025	NhaP-type Na H and K H
H2866_RS09885	COG0583	DNA-binding transcription factor activity
H2866_RS09890	COG1380	Effector of murein hydrolase LrgA
H2866_RS09900	COG1126	abc transporter atp-binding protein
H2866_RS09905	COG0765	amino acid transport
H2866_RS09910	COG4597	amino acid ABC transporter
H2866_RS09915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS09920	COG0504	CTP synthase activity
H2866_RS09925	COG1560	Kdo2-lipid A biosynthetic process
H2866_RS09945	COG2264	protein methyltransferase activity
H2866_RS09950	COG4145	pantothenate transmembrane transporter activity
H2866_RS09955	COG3924	membrane
H2866_RS09960	COG0439	Biotin carboxylase
H2866_RS09965	COG0511	ligase activity, forming carbon-carbon bonds
H2866_RS09970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H2866_RS09975	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H2866_RS09980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H2866_RS09985	COG2200	EAL domain
H2866_RS09985	COG2199	diguanylate cyclase activity
H2866_RS09990	COG1077	Cell shape determining protein MreB Mrl
H2866_RS09995	COG1792	Involved in formation and maintenance of cell shape
H2866_RS10000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H2866_RS10005	COG0424	maF-like protein
H2866_RS10010	COG1530	ribonuclease E activity
H2866_RS10015	COG3164	Protein of unknown function
H2866_RS10020	COG0312	modulator of DNA gyrase
H2866_RS10025	COG0583	DNA-binding transcription factor activity
H2866_RS10035	COG1566	PFAM secretion protein HlyD family protein
H2866_RS10040	COG1289	transmembrane transporter activity
H2866_RS10045	COG0531	amino acid
H2866_RS10060	COG2732	(Barnase) inhibitor
H2866_RS10065	COG3028	Belongs to the UPF0307 family
H2866_RS10070	COG0312	modulator of DNA gyrase
H2866_RS10075	COG3783	Cytochrome b(562)
H2866_RS10105	COG3964	amidohydrolase
H2866_RS10120	COG2706	6-phosphogluconolactonase activity
H2866_RS10125	COG3711	transcriptional antiterminator
H2866_RS10125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2866_RS10130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2866_RS10135	COG1660	Displays ATPase and GTPase activities
H2866_RS10145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H2866_RS10150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H2866_RS10155	COG1137	ATPase activity
H2866_RS10160	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H2866_RS10165	COG3117	lipopolysaccharide transmembrane transporter activity
H2866_RS10170	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H2866_RS10175	COG0517	IMP dehydrogenase activity
H2866_RS10175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H2866_RS10180	COG0530	calcium, potassium:sodium antiporter activity
H2866_RS10185	COG1127	ABC transporter
H2866_RS10190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2866_RS10195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H2866_RS10200	COG2854	intermembrane phospholipid transfer
H2866_RS10205	COG3113	response to antibiotic
H2866_RS10210	COG5007	Belongs to the BolA IbaG family
H2866_RS10215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2866_RS10220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2866_RS10225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2866_RS10230	COG3105	Protein conserved in bacteria
H2866_RS10235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H2866_RS10240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H2866_RS10245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2866_RS10250	COG0625	glutathione transferase activity
H2866_RS10255	COG2969	positive regulation of protein catabolic process
H2866_RS10260	COG0493	'glutamate synthase
H2866_RS10265	COG0069	glutamate synthase activity
H2866_RS10265	COG0070	glutamate synthase
H2866_RS10265	COG0067	glutamate synthase
H2866_RS10270	COG5002	protein histidine kinase activity
H2866_RS10270	COG2198	Histidine kinase
H2866_RS10270	COG0784	Response regulator, receiver
H2866_RS10280	COG2823	Periplasmic or secreted lipoprotein
H2866_RS10290	COG0792	nuclease activity
H2866_RS10295	COG3107	peptidoglycan biosynthetic process
H2866_RS10300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H2866_RS10310	COG1741	Belongs to the pirin family
H2866_RS10315	COG0583	DNA-binding transcription factor activity
H2866_RS10320	COG0435	Glutathione S-transferase
H2866_RS10325	COG2259	Doxx family
H2866_RS10335	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
H2866_RS10340	COG4575	ribosome binding
H2866_RS10355	COG0586	Pfam SNARE associated Golgi protein
H2866_RS10365	COG2271	Major facilitator Superfamily
H2866_RS10370	COG1904	glucuronate isomerase
H2866_RS10375	COG2721	sulfolactate sulfo-lyase activity
H2866_RS10400	COG2308	Evidence 4 Homologs of previously reported genes of
H2866_RS10415	COG0540	Belongs to the ATCase OTCase family
H2866_RS10420	COG0366	Alpha amylase catalytic
H2866_RS10425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2866_RS10435	COG0456	acetyltransferase
H2866_RS10445	COG2927	DNA polymerase III (CHI subunit)
H2866_RS10450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H2866_RS10455	COG0795	lipopolysaccharide-transporting ATPase activity
H2866_RS10460	COG0795	lipopolysaccharide-transporting ATPase activity
H2866_RS10465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2866_RS10480	COG0582	viral genome integration into host DNA
H2866_RS10485	COG1002	Type II restriction enzyme, methylase subunits
H2866_RS10490	COG1061	Type III restriction enzyme res subunit
H2866_RS10495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2866_RS10535	COG2003	Belongs to the UPF0758 family
H2866_RS10610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2866_RS10635	COG0659	secondary active sulfate transmembrane transporter activity
H2866_RS10640	COG0288	reversible hydration of carbon dioxide
H2866_RS10665	COG0583	DNA-binding transcription factor activity
H2866_RS10670	COG0667	Aldo Keto reductase
H2866_RS10680	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
H2866_RS10685	COG0456	acetyltransferase
H2866_RS10690	COG0738	Major facilitator superfamily
H2866_RS10695	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H2866_RS10700	COG2823	Periplasmic or secreted lipoprotein
H2866_RS10710	COG4667	esterase of the alpha-beta hydrolase superfamily
H2866_RS10715	COG0084	hydrolase, TatD family'
H2866_RS10720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H2866_RS10735	COG0813	purine-nucleoside phosphorylase activity
H2866_RS10740	COG3726	membrane protein affecting hemolysin expression
H2866_RS10745	COG0560	Phosphoserine phosphatase
H2866_RS10760	COG3397	chitin binding
H2866_RS10765	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H2866_RS10770	COG0604	alcohol dehydrogenase
H2866_RS10780	COG0488	(ABC) transporter
H2866_RS10795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2866_RS10800	COG0741	lytic transglycosylase activity
H2866_RS10805	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H2866_RS10815	COG0406	alpha-ribazole phosphatase activity
H2866_RS10820	COG2207	Transcriptional regulator
H2866_RS10820	COG3708	Transcriptional regulator
H2866_RS10825	COG3045	CreA protein
H2866_RS10830	COG0745	RESPONSE REGULATOR receiver
H2866_RS10835	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H2866_RS10860	COG3022	response to hydroperoxide
H2866_RS10865	COG1115	amino acid carrier protein
H2866_RS10875	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2866_RS10880	COG0477	Major facilitator Superfamily
H2866_RS10885	COG1584	GPR1 FUN34 yaaH family protein
H2866_RS10890	COG0443	Heat shock 70 kDa protein
H2866_RS10895	COG0484	heat shock protein binding
H2866_RS10900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2866_RS10905	COG0268	Binds directly to 16S ribosomal RNA
H2866_RS10910	COG0196	riboflavin kinase activity
H2866_RS10920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H2866_RS10925	COG1047	Peptidyl-prolyl cis-trans
H2866_RS10930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H2866_RS10945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H2866_RS10955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H2866_RS10965	COG0475	glutathione-regulated potassium exporter activity
H2866_RS10965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2866_RS10970	COG1280	lysine exporter protein (LysE YggA)
H2866_RS10980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2866_RS10985	COG2967	ApaG domain
H2866_RS10995	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H2866_RS11000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2866_RS11005	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H2866_RS11020	COG0564	pseudouridine synthase activity
H2866_RS11025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2866_RS11030	COG0417	DNA replication proofreading
H2866_RS11035	COG0586	Pfam SNARE associated Golgi protein
H2866_RS11045	COG1178	ABC-type Fe3 transport system permease component
H2866_RS11060	COG2814	Major facilitator Superfamily
H2866_RS11070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H2866_RS11075	COG0473	3-isopropylmalate dehydrogenase activity
H2866_RS11080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2866_RS11095	COG0028	Belongs to the TPP enzyme family
H2866_RS11105	COG1609	Transcriptional regulator
H2866_RS11110	COG2001	Belongs to the MraZ family
H2866_RS11115	COG0275	rRNA processing
H2866_RS11120	COG3116	cell division
H2866_RS11125	COG0768	penicillin binding
H2866_RS11130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2866_RS11135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2866_RS11140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2866_RS11150	COG0772	Belongs to the SEDS family
H2866_RS11155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2866_RS11160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2866_RS11165	COG1181	Belongs to the D-alanine--D-alanine ligase family
H2866_RS11170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H2866_RS11175	COG0849	cell division
H2866_RS11180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2866_RS11200	COG0653	protein targeting
H2866_RS11205	COG0494	nUDIX hydrolase
H2866_RS11210	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H2866_RS11215	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H2866_RS11225	COG0516	GMP reductase activity
H2866_RS11230	COG1459	type II secretion system
H2866_RS11235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2866_RS11240	COG4969	Belongs to the N-Me-Phe pilin family
H2866_RS11250	COG3023	N-Acetylmuramoyl-L-alanine amidase
H2866_RS11255	COG3725	Membrane protein required for beta-lactamase induction
H2866_RS11260	COG3940	Belongs to the glycosyl hydrolase 43 family
H2866_RS11265	COG2211	Major facilitator Superfamily
H2866_RS11270	COG1113	amino acid transport
H2866_RS11275	COG2186	Transcriptional regulator
H2866_RS11280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H2866_RS11285	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2866_RS11290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2866_RS11295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS11305	COG3112	Uncharacterised protein family (UPF0231)
H2866_RS11310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H2866_RS11325	COG2132	Multicopper oxidase
H2866_RS11335	COG0288	reversible hydration of carbon dioxide
H2866_RS11340	COG1131	(ABC) transporter
H2866_RS11345	COG0842	Transport permease protein
H2866_RS11355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS11375	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H2866_RS11380	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H2866_RS11390	COG0745	RESPONSE REGULATOR receiver
H2866_RS11395	COG0642	Histidine kinase
H2866_RS11400	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H2866_RS11405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2866_RS11410	COG0617	tRNA 3'-terminal CCA addition
H2866_RS11415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2866_RS11425	COG1489	DNA binding
H2866_RS11430	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H2866_RS11435	COG1643	Atp-dependent helicase
H2866_RS11440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2866_RS11445	COG4774	siderophore transport
H2866_RS11450	COG1120	ATPase activity
H2866_RS11455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2866_RS11460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2866_RS11465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H2866_RS11475	COG0316	Belongs to the HesB IscA family
H2866_RS11485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H2866_RS11490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H2866_RS11495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2866_RS11500	COG3835	regulator
H2866_RS11505	COG2271	Major facilitator Superfamily
H2866_RS11510	COG4948	Mandelate Racemase Muconate Lactonizing
H2866_RS11515	COG4948	Mandelate Racemase Muconate Lactonizing
H2866_RS11520	COG2721	sulfolactate sulfo-lyase activity
H2866_RS11530	COG2084	Dehydrogenase
H2866_RS11535	COG1929	Belongs to the glycerate kinase type-1 family
H2866_RS11545	COG2205	protein histidine kinase activity
H2866_RS11545	COG3437	response regulator, receiver
H2866_RS11545	COG4999	Histidine kinase
H2866_RS11545	COG3850	Histidine kinase
H2866_RS11550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2866_RS11555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2866_RS11560	COG3956	TIGRFAM MazG family protein
H2866_RS11565	COG0504	CTP synthase activity
H2866_RS11570	COG0148	phosphopyruvate hydratase activity
H2866_RS11575	COG0602	queuosine metabolic process
H2866_RS11580	COG0720	synthase
H2866_RS11585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2866_RS11585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2866_RS11590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2866_RS11595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2866_RS11600	COG0175	sulfate reduction
H2866_RS11610	COG1648	precorrin-2 dehydrogenase activity
H2866_RS11610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2866_RS11620	COG2895	sulfate adenylyltransferase (ATP) activity
H2866_RS11625	COG0529	Catalyzes the synthesis of activated sulfate
H2866_RS11635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2866_RS11640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H2866_RS11650	COG0585	pseudouridine synthase activity
H2866_RS11655	COG3469	chitinase activity
H2866_RS11660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H2866_RS11665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H2866_RS11670	COG4942	peptidase
H2866_RS11670	COG1388	LysM domain
H2866_RS11680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H2866_RS11685	COG0583	DNA-binding transcription factor activity
H2866_RS11695	COG2824	Alkylphosphonate utilization operon protein PhnA
H2866_RS11700	COG2951	lytic endotransglycosylase activity
H2866_RS11710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H2866_RS11715	COG2137	regulation of response to DNA damage stimulus
H2866_RS11720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H2866_RS11725	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H2866_RS11750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2866_RS11755	COG2918	glutathione biosynthetic process
H2866_RS11760	COG1854	S-ribosylhomocysteine lyase activity
H2866_RS11765	COG4536	flavin adenine dinucleotide binding
H2866_RS11770	COG4137	Cytochrome C assembly protein
H2866_RS11775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2866_RS11780	COG0228	four-way junction DNA binding
H2866_RS11785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H2866_RS11795	COG0335	large ribosomal subunit rRNA binding
H2866_RS11800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H2866_RS11805	COG1605	Chorismate mutase
H2866_RS11805	COG0287	Prephenate dehydrogenase
H2866_RS11810	COG1605	Chorismate mutase
H2866_RS11810	COG0077	Prephenate dehydratase
H2866_RS11815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H2866_RS11820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2866_RS11825	COG0564	pseudouridine synthase activity
H2866_RS11830	COG1496	oxidoreductase activity
H2866_RS11835	COG0542	response to heat
H2866_RS11860	COG0477	Major facilitator Superfamily
H2866_RS11865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2866_RS11870	COG0045	succinate-CoA ligase (ADP-forming) activity
H2866_RS11870	COG1042	CoA-binding domain protein
H2866_RS11870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2866_RS11875	COG3148	PFAM DTW domain containing protein
H2866_RS11880	COG3118	belongs to the thioredoxin family
H2866_RS11885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2866_RS11890	COG2207	Transcriptional regulator
H2866_RS11900	COG2814	Major facilitator Superfamily
H2866_RS11905	COG1566	PFAM secretion protein HlyD family protein
H2866_RS11910	COG1538	Outer membrane efflux protein
H2866_RS11915	COG1846	Transcriptional regulator
H2866_RS11925	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H2866_RS11930	COG2814	Major facilitator Superfamily
H2866_RS11940	COG2113	Glycine betaine
H2866_RS11945	COG2113	Glycine betaine
H2866_RS11950	COG4176	ABC-type proline glycine betaine transport system permease component
H2866_RS11960	COG4565	transcriptional regulatory protein
H2866_RS11970	COG3493	citrate carrier protein
H2866_RS11985	COG1780	Probably involved in ribonucleotide reductase function
H2866_RS11990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2866_RS11995	COG4575	ribosome binding
H2866_RS12000	COG0477	Major facilitator Superfamily
H2866_RS12020	COG0384	phenazine biosynthesis protein PhzF
H2866_RS12030	COG0583	DNA-binding transcription factor activity
H2866_RS12035	COG1473	amidohydrolase
H2866_RS12085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS12125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H2866_RS12130	COG2867	negative regulation of translational initiation
H2866_RS12135	COG2914	Belongs to the UPF0125 (RnfH) family
H2866_RS12145	COG0497	DNA recombination
H2866_RS12150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2866_RS12155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H2866_RS12160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H2866_RS12165	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H2866_RS12170	COG0513	Belongs to the DEAD box helicase family
H2866_RS12180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H2866_RS12200	COG3086	response to oxidative stress
H2866_RS12220	COG0481	GTPase activity
H2866_RS12230	COG0571	ribonuclease III activity
H2866_RS12235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2866_RS12240	COG1381	Involved in DNA repair and RecF pathway recombination
H2866_RS12245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H2866_RS12255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2866_RS12260	COG1737	Transcriptional regulator
H2866_RS12265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H2866_RS12270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2866_RS12270	COG1263	PTS System
H2866_RS12275	COG0560	Phosphoserine phosphatase
H2866_RS12280	COG0590	tRNA wobble adenosine to inosine editing
H2866_RS12285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H2866_RS12315	COG2897	thiosulfate sulfurtransferase activity
H2866_RS12330	COG2226	methyltransferase
H2866_RS12335	COG2354	Protein conserved in bacteria
H2866_RS12350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H2866_RS12375	COG4126	flavin adenine dinucleotide binding
H2866_RS12380	COG3123	guanosine phosphorylase activity
H2866_RS12385	COG2974	May be involved in recombination
H2866_RS12390	COG1940	carbohydrate kinase activity
H2866_RS12400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2866_RS12420	COG0419	ATPase involved in DNA repair
H2866_RS12425	COG0420	3'-5' exonuclease activity
H2866_RS12430	COG0745	RESPONSE REGULATOR receiver
H2866_RS12435	COG5002	protein histidine kinase activity
H2866_RS12440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H2866_RS12450	COG1113	amino acid transport
H2866_RS12460	COG0450	alkyl hydroperoxide reductase
H2866_RS12465	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H2866_RS12475	COG0343	queuine tRNA-ribosyltransferase activity
H2866_RS12480	COG1862	Preprotein translocase
H2866_RS12485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2866_RS12490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2866_RS12500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2866_RS12505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2866_RS12505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2866_RS12510	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H2866_RS12520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H2866_RS12525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2866_RS12530	COG0667	Aldo Keto reductase
H2866_RS12535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H2866_RS12540	COG0142	geranyltranstransferase activity
H2866_RS12565	COG0693	protein deglycase activity
H2866_RS12570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H2866_RS12580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H2866_RS12590	COG1666	GTP binding
H2866_RS12595	COG2814	Major facilitator Superfamily
H2866_RS12600	COG0109	protoheme IX farnesyltransferase activity
H2866_RS12605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H2866_RS12610	COG1845	cytochrome c oxidase, subunit III
H2866_RS12615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2866_RS12620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2866_RS12625	COG2223	nitrite transmembrane transporter activity
H2866_RS12630	COG3056	Lipoprotein
H2866_RS12635	COG0271	Belongs to the BolA IbaG family
H2866_RS12645	COG0740	serine-type endopeptidase activity
H2866_RS12650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H2866_RS12655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H2866_RS12665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2866_RS12670	COG1555	photosystem II stabilization
H2866_RS12675	COG0824	Thioesterase
H2866_RS12680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H2866_RS12685	COG4533	DNA binding
H2866_RS12690	COG0561	phosphatase activity
H2866_RS12700	COG1522	sequence-specific DNA binding
H2866_RS12705	COG1132	(ABC) transporter
H2866_RS12710	COG1132	(ABC) transporter
H2866_RS12715	COG0347	Belongs to the P(II) protein family
H2866_RS12720	COG0004	ammonium transporteR
H2866_RS12725	COG1946	Acyl-CoA thioesterase
H2866_RS12730	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H2866_RS12735	COG3695	enzyme binding
H2866_RS12745	COG2252	PERMEase
H2866_RS12750	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H2866_RS12755	COG0583	DNA-binding transcription factor activity
H2866_RS12775	COG1121	(ABC) transporter
H2866_RS12780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2866_RS12785	COG0803	Belongs to the bacterial solute-binding protein 9 family
H2866_RS12790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H2866_RS12800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2866_RS12805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2866_RS12815	COG3264	Mechanosensitive ion channel
H2866_RS12815	COG1196	nuclear chromosome segregation
H2866_RS12830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2866_RS12835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2866_RS12840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H2866_RS12845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2866_RS12880	COG0563	adenylate kinase activity
H2866_RS12885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H2866_RS12890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2866_RS12895	COG4651	solute:proton antiporter activity
H2866_RS12895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2866_RS12900	COG2223	nitrite transmembrane transporter activity
H2866_RS12905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2866_RS12910	COG3735	TraB family
H2866_RS12915	COG2217	Heavy metal translocating P-type atpase
H2866_RS12925	COG1585	Membrane protein implicated in regulation of membrane protease activity
H2866_RS12930	COG0330	HflC and HflK could
H2866_RS12935	COG3118	belongs to the thioredoxin family
H2866_RS12940	COG0300	oxidoreductase activity
H2866_RS12945	COG2755	lipolytic protein G-D-S-L family
H2866_RS12950	COG4181	ATPase activity
H2866_RS12955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H2866_RS12965	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2866_RS12970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H2866_RS12980	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2866_RS12985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2866_RS12990	COG0215	cysteine-tRNA ligase activity
H2866_RS12995	COG2501	S4 domain
H2866_RS13000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H2866_RS13040	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS13045	COG1129	ABC transporter
H2866_RS13085	COG0477	Major facilitator Superfamily
H2866_RS13095	COG4772	TonB-dependent receptor
H2866_RS13100	COG4993	Dehydrogenase
H2866_RS13120	COG1505	serine-type exopeptidase activity
H2866_RS13130	COG3416	Protein conserved in bacteria
H2866_RS13140	COG2814	Major facilitator Superfamily
H2866_RS13150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2866_RS13160	COG0436	Aminotransferase
H2866_RS13170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2866_RS13180	COG0765	amino acid transport
H2866_RS13185	COG1126	abc transporter atp-binding protein
H2866_RS13190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2866_RS13195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2866_RS13205	COG2921	Belongs to the UPF0250 family
H2866_RS13210	COG1686	Belongs to the peptidase S11 family
H2866_RS13215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H2866_RS13220	COG0772	Belongs to the SEDS family
H2866_RS13225	COG0768	penicillin binding
H2866_RS13230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H2866_RS13235	COG0799	negative regulation of ribosome biogenesis
H2866_RS13245	COG1466	dna polymerase III delta subunit
H2866_RS13250	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H2866_RS13255	COG0495	leucyl-tRNA aminoacylation
H2866_RS13260	COG2888	peptidyl-tyrosine sulfation
H2866_RS13265	COG1126	abc transporter atp-binding protein
H2866_RS13270	COG0765	amino acid transport
H2866_RS13275	COG0765	amino acid transport
H2866_RS13285	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H2866_RS13290	COG4535	Mg2 and Co2 transporter CorC
H2866_RS13295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H2866_RS13300	COG1702	phosphate starvation-inducible protein PhoH
H2866_RS13305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2866_RS13310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2866_RS13345	COG0367	asparagine synthase
H2866_RS13350	COG0647	UMP catabolic process
H2866_RS13355	COG1940	carbohydrate kinase activity
H2866_RS13355	COG1846	Transcriptional regulator
H2866_RS13360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H2866_RS13365	COG0363	glucosamine-6-phosphate deaminase activity
H2866_RS13370	COG2190	(PTS) system
H2866_RS13370	COG1263	PTS System
H2866_RS13370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2866_RS13380	COG0735	belongs to the Fur family
H2866_RS13395	COG0596	Alpha beta hydrolase
H2866_RS13400	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H2866_RS13405	COG0033	Phosphoglucomutase
H2866_RS13410	COG1695	Transcriptional regulator
H2866_RS13415	COG0745	RESPONSE REGULATOR receiver
H2866_RS13420	COG2205	protein histidine kinase activity
H2866_RS13425	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H2866_RS13430	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H2866_RS13435	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H2866_RS13450	COG3272	Protein of unknown function (DUF1722)
H2866_RS13455	COG0415	Belongs to the DNA photolyase family
H2866_RS13460	COG5212	phosphodiesterase
H2866_RS13465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2866_RS13475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H2866_RS13480	COG1984	allophanate hydrolase subunit 2
H2866_RS13485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H2866_RS13505	COG0372	Belongs to the citrate synthase family
H2866_RS13510	COG2009	succinate dehydrogenase
H2866_RS13515	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H2866_RS13520	COG1053	succinate dehydrogenase
H2866_RS13525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2866_RS13530	COG0567	Dehydrogenase, E1 component
H2866_RS13535	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2866_RS13545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H2866_RS13550	COG1271	oxidase subunit
H2866_RS13555	COG1294	oxidase, subunit
H2866_RS13560	COG4890	Cyd operon protein YbgT
H2866_RS13565	COG0824	Thioesterase
H2866_RS13570	COG0811	peptide transport
H2866_RS13575	COG0848	biopolymer transport protein
H2866_RS13580	COG3064	Membrane
H2866_RS13580	COG3064	Membrane
H2866_RS13585	COG0823	Involved in the tonB-independent uptake of proteins
H2866_RS13590	COG2885	chlorophyll binding
H2866_RS13595	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H2866_RS13635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2866_RS13650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H2866_RS13655	COG0588	phosphoglycerate mutase activity
H2866_RS13670	COG2017	converts alpha-aldose to the beta-anomer
H2866_RS13675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H2866_RS13680	COG1085	galactose-1-phosphate uridylyltransferase
H2866_RS13685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2866_RS13690	COG1119	ATPase activity
H2866_RS13695	COG3585	molybdate ion transport
H2866_RS13695	COG2005	Transcriptional regulator
H2866_RS13705	COG0725	ABC transporter, periplasmic molybdate-binding protein
H2866_RS13710	COG4149	molybdate abc transporter
H2866_RS13720	COG0561	phosphatase activity
H2866_RS13730	COG4677	pectinesterase activity
H2866_RS13735	COG1881	PFAM PEBP family protein
H2866_RS13745	COG2130	NADP-dependent
H2866_RS13755	COG0436	Aminotransferase
H2866_RS13770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H2866_RS13775	COG0156	8-amino-7-oxononanoate synthase activity
H2866_RS13780	COG2226	methyltransferase
H2866_RS13785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H2866_RS13795	COG0556	nucleotide-excision repair
H2866_RS13800	COG4628	conserved protein (DUF2132)
H2866_RS13805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H2866_RS13810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2866_RS13815	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2866_RS13825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H2866_RS13830	COG0314	molybdopterin synthase activity
H2866_RS13835	COG0670	Belongs to the BI1 family
H2866_RS13845	COG0513	Belongs to the DEAD box helicase family
H2866_RS13860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2866_RS13865	COG4771	TonB-dependent receptor
H2866_RS13870	COG0477	Major facilitator Superfamily
H2866_RS13875	COG1228	amidohydrolase
H2866_RS13885	COG0583	DNA-binding transcription factor activity
H2866_RS13890	COG1686	Belongs to the peptidase S11 family
H2866_RS13920	COG0277	FAD linked oxidase domain protein
H2866_RS13930	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H2866_RS13945	COG1012	belongs to the aldehyde dehydrogenase family
H2866_RS13955	COG1181	Belongs to the D-alanine--D-alanine ligase family
H2866_RS14015	COG1309	transcriptional regulator
H2866_RS14025	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H2866_RS14030	COG1473	amidohydrolase
H2866_RS14035	COG1473	amidohydrolase
H2866_RS14040	COG0583	DNA-binding transcription factor activity
H2866_RS14050	COG0477	Major facilitator Superfamily
H2866_RS14060	COG1732	Glycine betaine
H2866_RS14065	COG1174	glycine betaine transport
H2866_RS14070	COG1125	glycine betaine transport
H2866_RS14075	COG1174	glycine betaine transport
H2866_RS14090	COG0697	spore germination
H2866_RS14110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2866_RS14125	COG0300	oxidoreductase activity
H2866_RS14135	COG0789	Transcriptional regulator
H2866_RS14150	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H2866_RS14165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2866_RS14180	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H2866_RS14185	COG1126	abc transporter atp-binding protein
H2866_RS14190	COG0765	amino acid transport
H2866_RS14195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS14200	COG0783	Belongs to the Dps family
H2866_RS14215	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H2866_RS14220	COG5006	permease, DMT superfamily
H2866_RS14225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H2866_RS14230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H2866_RS14235	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H2866_RS14265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2866_RS14275	COG1012	belongs to the aldehyde dehydrogenase family
H2866_RS14280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H2866_RS14300	COG0488	(ABC) transporter
H2866_RS14305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2866_RS14310	COG0303	'Molybdopterin
H2866_RS14315	COG1349	DNA-binding transcription factor activity
H2866_RS14325	COG4172	Belongs to the ABC transporter superfamily
H2866_RS14330	COG0747	negative chemotaxis
H2866_RS14335	COG0601	transmembrane transport
H2866_RS14340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS14350	COG0583	DNA-binding transcription factor activity
H2866_RS14360	COG0302	gtp cyclohydrolase
H2866_RS14365	COG2311	Membrane
H2866_RS14370	COG1609	Transcriptional regulator
H2866_RS14390	COG2949	membrane
H2866_RS14395	COG0281	malic enzyme
H2866_RS14400	COG0295	cytidine deaminase activity
H2866_RS14410	COG4160	amino acid transport
H2866_RS14415	COG4215	(ABC) transporter
H2866_RS14420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS14425	COG1126	abc transporter atp-binding protein
H2866_RS14430	COG3023	N-Acetylmuramoyl-L-alanine amidase
H2866_RS14435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2866_RS14440	COG0702	epimerase
H2866_RS14445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H2866_RS14450	COG0028	Belongs to the TPP enzyme family
H2866_RS14455	COG2431	L-lysine efflux transmembrane transporter activity
H2866_RS14460	COG3593	DNA synthesis involved in DNA repair
H2866_RS14465	COG2990	Protein conserved in bacteria
H2866_RS14470	COG1278	Cold shock
H2866_RS14475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2866_RS14480	COG0542	response to heat
H2866_RS14485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H2866_RS14490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H2866_RS14495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H2866_RS14500	COG4988	ABC transporter
H2866_RS14505	COG0492	ferredoxin-NADP+ reductase activity
H2866_RS14515	COG3107	peptidoglycan biosynthetic process
H2866_RS14515	COG1674	ftsk spoiiie
H2866_RS14520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2866_RS14525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2866_RS14530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H2866_RS14535	COG2814	Major facilitator Superfamily
H2866_RS14540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H2866_RS14545	COG1882	Formate acetyltransferase
H2866_RS14550	COG2116	formate transmembrane transporter activity
H2866_RS14555	COG1944	ATP diphosphatase activity
H2866_RS14560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H2866_RS14565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2866_RS14570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H2866_RS14575	COG0539	negative regulation of cytoplasmic translation
H2866_RS14580	COG0776	regulation of translation
H2866_RS14585	COG2333	competence protein COMEC
H2866_RS14585	COG0658	competence protein
H2866_RS14590	COG1132	(ABC) transporter
H2866_RS14595	COG1663	tetraacyldisaccharide 4'-kinase activity
H2866_RS14600	COG1278	Cold shock
H2866_RS14605	COG3214	Protein conserved in bacteria
H2866_RS14610	COG2835	tetraacyldisaccharide 4'-kinase activity
H2866_RS14620	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H2866_RS14625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2866_RS14630	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H2866_RS14640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H2866_RS14645	COG2989	Protein conserved in bacteria
H2866_RS14650	COG3108	Peptidase M15
H2866_RS14655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2866_RS14660	COG1448	Aminotransferase
H2866_RS14670	COG0017	Asparaginyl-tRNA synthetase
H2866_RS14675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H2866_RS14680	COG0308	aminopeptidase N
H2866_RS14690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2866_RS14695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS14700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2866_RS14705	COG0431	NADPH-dependent FMN reductase
H2866_RS14720	COG0633	Ferredoxin
H2866_RS14720	COG3217	Mosc domain protein beta barrel domain protein
H2866_RS14725	COG0116	Belongs to the methyltransferase superfamily
H2866_RS14725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H2866_RS14730	COG0488	(ABC) transporter
H2866_RS14735	COG2995	paraquat-inducible protein a
H2866_RS14740	COG3008	intermembrane lipid transfer
H2866_RS14740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H2866_RS14745	COG3009	Protein conserved in bacteria
H2866_RS14755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H2866_RS14760	COG1067	ATP-dependent peptidase activity
H2866_RS14780	COG3070	regulator of competence-specific genes
H2866_RS14785	COG1289	transmembrane transporter activity
H2866_RS14790	COG3304	Inner membrane component domain
H2866_RS14795	COG0210	DNA helicase
H2866_RS14800	COG1803	Methylglyoxal synthase
H2866_RS14810	COG1832	CoA-binding protein
H2866_RS14815	COG3785	DNA binding
H2866_RS14820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H2866_RS14825	COG1254	Belongs to the acylphosphatase family
H2866_RS14830	COG2920	part of a sulfur-relay system
H2866_RS14835	COG0670	Belongs to the BI1 family
H2866_RS14850	COG1309	transcriptional regulator
H2866_RS14870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2866_RS14875	COG3263	regulation of cellular component size
H2866_RS14885	COG2233	PERMEase
H2866_RS14890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2866_RS14895	COG0778	Nitroreductase
H2866_RS14900	COG2267	carboxylic ester hydrolase activity
H2866_RS14905	COG0251	oxidation-reduction process
H2866_RS14910	COG1335	isochorismatase
H2866_RS14915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS14920	COG1309	transcriptional regulator
H2866_RS14925	COG1113	amino acid transport
H2866_RS14930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2866_RS14950	COG2197	response regulator
H2866_RS14955	COG0322	excinuclease ABC activity
H2866_RS14960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2866_RS15010	COG3772	lysozyme
H2866_RS15030	COG0477	Major facilitator Superfamily
H2866_RS15040	COG0477	Major facilitator Superfamily
H2866_RS15055	COG4297	protein containing double-stranded beta helix domain
H2866_RS15070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2866_RS15075	COG1349	DNA-binding transcription factor activity
H2866_RS15080	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H2866_RS15140	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H2866_RS15145	COG2943	transferase activity, transferring hexosyl groups
H2866_RS15155	COG5645	(Lipo)protein
H2866_RS15165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2866_RS15180	COG2814	Major facilitator Superfamily
H2866_RS15190	COG1560	Kdo2-lipid A biosynthetic process
H2866_RS15195	COG1902	pentaerythritol trinitrate reductase activity
H2866_RS15200	COG1054	Belongs to the UPF0176 family
H2866_RS15205	COG0477	Major facilitator Superfamily
H2866_RS15230	COG0418	dihydroorotase activity
H2866_RS15240	COG1530	ribonuclease E activity
H2866_RS15240	COG1530	ribonuclease E activity
H2866_RS15245	COG0564	pseudouridine synthase activity
H2866_RS15250	COG0424	maF-like protein
H2866_RS15255	COG1399	metal-binding, possibly nucleic acid-binding protein
H2866_RS15260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H2866_RS15265	COG0416	fatty acid biosynthetic process
H2866_RS15285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2866_RS15290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2866_RS15295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2866_RS15300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2866_RS15315	COG0084	hydrolase, TatD family'
H2866_RS15320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2866_RS15320	COG1263	PTS System
H2866_RS15325	COG0537	adenosine 5'-monophosphoramidase activity
H2866_RS15330	COG5633	Lipoprotein
H2866_RS15335	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
H2866_RS15350	COG3150	esterase
H2866_RS15355	COG1252	NADH dehydrogenase
H2866_RS15360	COG3134	Outer membrane lipoprotein
H2866_RS15365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2866_RS15370	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2866_RS15375	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2866_RS15385	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2866_RS15400	COG2850	peptidyl-arginine hydroxylation
H2866_RS15410	COG0745	RESPONSE REGULATOR receiver
H2866_RS15415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2866_RS15420	COG2915	High frequency lysogenization protein hflD homolog
H2866_RS15445	COG0538	isocitrate dehydrogenase activity
H2866_RS15525	COG2226	methyltransferase
H2866_RS15530	COG4811	Protein of unknown function (DUF986)
H2866_RS15535	COG3716	PTS system mannose fructose sorbose family IID component
H2866_RS15540	COG3715	PTS system
H2866_RS15545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2866_RS15545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2866_RS15550	COG1253	flavin adenine dinucleotide binding
H2866_RS15555	COG1760	l-serine dehydratase
H2866_RS15560	COG0494	nUDIX hydrolase
H2866_RS15565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H2866_RS15570	COG3140	Belongs to the UPF0181 family
H2866_RS15575	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H2866_RS15585	COG0513	Belongs to the DEAD box helicase family
H2866_RS15590	COG1770	oligopeptidase
H2866_RS15595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2866_RS15615	COG1528	Iron-storage protein
H2866_RS15620	COG2372	response to copper ion
H2866_RS15625	COG1276	copper resistance
H2866_RS15660	COG2801	Transposase and inactivated derivatives
H2866_RS15665	COG1051	belongs to the nudix hydrolase family
H2866_RS15685	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H2866_RS15690	COG3340	Belongs to the peptidase S51 family
H2866_RS15700	COG1473	amidohydrolase
H2866_RS15730	COG3008	intermembrane lipid transfer
H2866_RS15735	COG2995	paraquat-inducible protein a
H2866_RS15740	COG1956	GAF domain-containing protein
H2866_RS15755	COG0501	Belongs to the peptidase M48B family
H2866_RS15760	COG2814	Major facilitator Superfamily
H2866_RS15770	COG1823	symporter activity
H2866_RS15775	COG1988	membrane-bound metal-dependent
H2866_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS15790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2866_RS15800	COG3001	Fructosamine kinase
H2866_RS15810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H2866_RS15825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H2866_RS15835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H2866_RS15845	COG0776	regulation of translation
H2866_RS15860	COG4139	cobalamin transport
H2866_RS15865	COG0386	Belongs to the glutathione peroxidase family
H2866_RS15870	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H2866_RS15880	COG1215	transferase activity, transferring glycosyl groups
H2866_RS15885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H2866_RS15885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2866_RS15900	COG2076	Multidrug Resistance protein
H2866_RS15905	COG2076	Multidrug Resistance protein
H2866_RS15910	COG0791	NLP P60 protein
H2866_RS15915	COG0095	Lipoate-protein ligase
H2866_RS15940	COG1309	transcriptional regulator
H2866_RS15955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2866_RS15960	COG4558	Periplasmic binding protein
H2866_RS15965	COG3720	iron ion transport
H2866_RS15970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H2866_RS15980	COG0574	Belongs to the PEP-utilizing enzyme family
H2866_RS15980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2866_RS15985	COG0628	permease
H2866_RS15990	COG0277	FAD linked oxidase domain protein
H2866_RS15990	COG0247	lactate metabolic process
H2866_RS15995	COG2050	protein possibly involved in aromatic compounds catabolism
H2866_RS16005	COG0316	Belongs to the HesB IscA family
H2866_RS16010	COG0719	Fe-S assembly protein
H2866_RS16015	COG0396	ATPase activity
H2866_RS16020	COG0719	Fe-S assembly protein
H2866_RS16025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2866_RS16030	COG2166	iron-sulfur cluster assembly
H2866_RS16035	COG1388	LysM domain
H2866_RS16035	COG1376	ErfK ybiS ycfS ynhG family protein
H2866_RS16060	COG0534	Mate efflux family protein
H2866_RS16065	COG0307	riboflavin synthase, alpha
H2866_RS16070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2866_RS16075	COG2814	Major facilitator Superfamily
H2866_RS16080	COG0583	DNA-binding transcription factor activity
H2866_RS16085	COG1609	Transcriptional regulator
H2866_RS16095	COG0791	NLP P60 protein
H2866_RS16100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H2866_RS16105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2866_RS16115	COG1902	pentaerythritol trinitrate reductase activity
H2866_RS16120	COG3313	Fe-S protein
H2866_RS16125	COG4989	oxidoreductase activity
H2866_RS16135	COG1566	PFAM secretion protein HlyD family protein
H2866_RS16145	COG1846	Transcriptional regulator
H2866_RS16155	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H2866_RS16160	COG3895	Periplasmic Protein
H2866_RS16170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2866_RS16180	COG0625	glutathione transferase activity
H2866_RS16185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2866_RS16195	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H2866_RS16200	COG3104	oligopeptide transport
H2866_RS16205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2866_RS16205	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2866_RS16215	COG4172	Belongs to the ABC transporter superfamily
H2866_RS16225	COG4168	peptide transport system, permease
H2866_RS16230	COG4166	transmembrane transport
H2866_RS16235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H2866_RS16240	COG1842	Phage shock protein A
H2866_RS16250	COG1983	PspC domain protein
H2866_RS16260	COG3106	COG3106 Predicted ATPase
H2866_RS16265	COG3768	UPF0283 membrane protein
H2866_RS16275	COG0788	formyltetrahydrofolate deformylase activity
H2866_RS16280	COG3012	SEC-C Motif Domain Protein
H2866_RS16285	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2866_RS16290	COG0745	RESPONSE REGULATOR receiver
H2866_RS16305	COG2916	Histone family protein nucleoid-structuring protein H-NS
H2866_RS16315	COG1454	alcohol dehydrogenase
H2866_RS16315	COG1012	belongs to the aldehyde dehydrogenase family
H2866_RS16320	COG2095	MarC family integral membrane protein
H2866_RS16325	COG0542	response to heat
H2866_RS16335	COG0601	transmembrane transport
H2866_RS16340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS16345	COG0444	Belongs to the ABC transporter superfamily
H2866_RS16355	COG3099	Belongs to the UPF0263 family
H2866_RS16375	COG2350	Protein conserved in bacteria
H2866_RS16390	COG1607	acyl-coa hydrolase
H2866_RS16395	COG2917	probably involved in intracellular septation
H2866_RS16410	COG0727	PFAM Uncharacterised protein family (UPF0153)
H2866_RS16415	COG3047	cAMP biosynthetic process
H2866_RS16425	COG0159	tryptophan synthase activity
H2866_RS16430	COG0133	tryptophan synthase activity
H2866_RS16435	COG0134	indole-3-glycerol-phosphate synthase activity
H2866_RS16435	COG0135	phosphoribosylanthranilate isomerase activity
H2866_RS16450	COG0613	PHP domain protein
H2866_RS16455	COG0009	L-threonylcarbamoyladenylate synthase
H2866_RS16460	COG1187	pseudouridine synthase activity
H2866_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS16475	COG0616	signal peptide processing
H2866_RS16490	COG0583	DNA-binding transcription factor activity
H2866_RS16495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2866_RS16505	COG0671	phosphoesterase, PA-phosphatase related
H2866_RS16510	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H2866_RS16515	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H2866_RS16530	COG0023	Translation Initiation Factor
H2866_RS16540	COG0235	Class ii aldolase
H2866_RS16560	COG1966	Carbon starvation protein
H2866_RS16565	COG3678	ATP-independent chaperone mediated protein folding
H2866_RS16570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2866_RS16715	COG1012	belongs to the aldehyde dehydrogenase family
H2866_RS16720	COG3724	N-succinylarginine dihydrolase activity
H2866_RS16730	COG0038	chloride channel
H2866_RS16735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H2866_RS16740	COG1140	nitrate reductase beta subunit
H2866_RS16745	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H2866_RS16750	COG2181	nitrate reductase activity
H2866_RS16765	COG4948	Mandelate Racemase Muconate Lactonizing
H2866_RS16775	COG0747	negative chemotaxis
H2866_RS16780	COG0601	transmembrane transport
H2866_RS16785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS16805	COG0583	DNA-binding transcription factor activity
H2866_RS16810	COG4932	domain protein
H2866_RS16815	COG2197	response regulator
H2866_RS16820	COG3850	Histidine kinase
H2866_RS16825	COG2223	nitrite transmembrane transporter activity
H2866_RS16830	COG0371	Dehydrogenase
H2866_RS16835	COG0477	Major facilitator Superfamily
H2866_RS16850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2866_RS16885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS16895	COG0667	Aldo Keto reductase
H2866_RS16905	COG1309	transcriptional regulator
H2866_RS16910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2866_RS16925	COG1070	Carbohydrate kinase
H2866_RS16935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H2866_RS16940	COG1309	transcriptional regulator
H2866_RS16965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2866_RS16990	COG0477	Major facilitator Superfamily
H2866_RS17015	COG1349	DNA-binding transcription factor activity
H2866_RS17025	COG0583	DNA-binding transcription factor activity
H2866_RS17040	COG1522	sequence-specific DNA binding
H2866_RS17050	COG4565	transcriptional regulatory protein
H2866_RS17055	COG3290	protein histidine kinase activity
H2866_RS17070	COG2814	Major facilitator Superfamily
H2866_RS17080	COG2423	ornithine cyclodeaminase activity
H2866_RS17090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2866_RS17100	COG2837	iron assimilation
H2866_RS17105	COG2822	iron ion transport
H2866_RS17115	COG0667	Aldo Keto reductase
H2866_RS17125	COG0473	3-isopropylmalate dehydrogenase activity
H2866_RS17135	COG2186	Transcriptional regulator
H2866_RS17140	COG2130	NADP-dependent
H2866_RS17145	COG0156	8-amino-7-oxononanoate synthase activity
H2866_RS17170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H2866_RS17175	COG2814	Major facilitator Superfamily
H2866_RS17190	COG0436	Aminotransferase
H2866_RS17195	COG0747	negative chemotaxis
H2866_RS17200	COG3141	response to X-ray
H2866_RS17205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2866_RS17215	COG0583	DNA-binding transcription factor activity
H2866_RS17240	COG2837	iron assimilation
H2866_RS17245	COG2259	Doxx family
H2866_RS17250	COG0583	DNA-binding transcription factor activity
H2866_RS17275	COG0012	GTP binding
H2866_RS17280	COG0659	secondary active sulfate transmembrane transporter activity
H2866_RS17285	COG0193	aminoacyl-tRNA hydrolase activity
H2866_RS17295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2866_RS17300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H2866_RS17310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H2866_RS17315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H2866_RS17320	COG2890	protein-(glutamine-N5) methyltransferase activity
H2866_RS17335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H2866_RS17360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2866_RS17365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H2866_RS17370	COG3381	protein complex oligomerization
H2866_RS17380	COG2999	glutathione oxidoreductase activity
H2866_RS17390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2866_RS17395	COG3132	Protein of unknown function, DUF480
H2866_RS17400	COG0673	inositol 2-dehydrogenase activity
H2866_RS17410	COG0018	arginyl-trna synthetase
H2866_RS17415	COG3102	Protein conserved in bacteria
H2866_RS17420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2866_RS17425	COG3142	Participates in the control of copper homeostasis
H2866_RS17440	COG0386	Belongs to the glutathione peroxidase family
H2866_RS17445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H2866_RS17455	COG2860	membrane
H2866_RS17460	COG2207	Transcriptional regulator
H2866_RS17460	COG3708	Transcriptional regulator
H2866_RS17470	COG3708	Transcriptional regulator
H2866_RS17470	COG2207	Transcriptional regulator
H2866_RS17480	COG1396	sequence-specific DNA binding
H2866_RS17490	COG2200	EAL domain
H2866_RS17580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2866_RS17590	COG1819	glycosyl
H2866_RS17605	COG0534	Mate efflux family protein
H2866_RS17635	COG0531	amino acid
H2866_RS17655	COG2226	methyltransferase
H2866_RS17660	COG1801	Protein of unknown function DUF72
H2866_RS17665	COG1335	isochorismatase
H2866_RS17670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H2866_RS17675	COG0494	nUDIX hydrolase
H2866_RS17680	COG0217	transcriptional regulatory protein
H2866_RS17690	COG0632	four-way junction helicase activity
H2866_RS17695	COG2255	four-way junction helicase activity
H2866_RS17700	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H2866_RS17705	COG0739	heme binding
H2866_RS17710	COG1560	Kdo2-lipid A biosynthetic process
H2866_RS17715	COG0469	pyruvate kinase activity
H2866_RS17720	COG1737	Transcriptional regulator
H2866_RS17725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H2866_RS17735	COG0800	Aldolase
H2866_RS17740	COG0251	oxidation-reduction process
H2866_RS17745	COG1199	ATP-dependent helicase activity
H2866_RS17755	COG3065	identical protein binding
H2866_RS17765	COG0318	PFAM AMP-dependent synthetase and ligase
H2866_RS17770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H2866_RS17780	COG1309	transcriptional regulator
H2866_RS17795	COG0583	DNA-binding transcription factor activity
H2866_RS17805	COG1653	transport
H2866_RS17825	COG3842	ATPase activity
H2866_RS17835	COG0366	Alpha amylase catalytic
H2866_RS17870	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H2866_RS17875	COG2894	cell division
H2866_RS17880	COG0850	regulation of cytokinetic process
H2866_RS17885	COG3100	YcgL domain-containing protein
H2866_RS17890	COG2951	lytic endotransglycosylase activity
H2866_RS17895	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2866_RS17900	COG2983	Belongs to the UPF0260 family
H2866_RS17905	COG1278	Cold shock
H2866_RS18080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H2866_RS18085	COG2186	Transcriptional regulator
H2866_RS18090	COG2719	SpoVR family
H2866_RS18105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2866_RS18110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2866_RS18120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H2866_RS18125	COG3137	Salt-induced outer membrane protein
H2866_RS18140	COG2718	Belongs to the UPF0229 family
H2866_RS18145	COG2766	serine protein kinase
H2866_RS18150	COG3713	MltA-interacting MipA family protein
H2866_RS18155	COG0656	L-ascorbic acid biosynthetic process
H2866_RS18170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2866_RS18175	COG3139	Protein of unknown function (DUF1315)
H2866_RS18190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2866_RS18205	COG1335	isochorismatase
H2866_RS18210	COG0252	asparaginase activity
H2866_RS18215	COG0616	signal peptide processing
H2866_RS18220	COG0778	Nitroreductase
H2866_RS18225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2866_RS18230	COG0494	nUDIX hydrolase
H2866_RS18235	COG0708	Exodeoxyribonuclease III
H2866_RS18245	COG0583	DNA-binding transcription factor activity
H2866_RS18250	COG0129	dihydroxy-acid dehydratase activity
H2866_RS18255	COG0626	cystathionine gamma-synthase activity
H2866_RS18260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS18265	COG3135	benzoate transporter
H2866_RS18270	COG4948	Mandelate Racemase Muconate Lactonizing
H2866_RS18275	COG0625	glutathione transferase activity
H2866_RS18300	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H2866_RS18305	COG4948	Mandelate Racemase Muconate Lactonizing
H2866_RS18330	COG0601	transmembrane transport
H2866_RS18335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS18345	COG0037	tRNA processing
H2866_RS18360	COG0640	Transcriptional regulator
H2866_RS18380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2866_RS18385	COG0747	negative chemotaxis
H2866_RS18390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS18395	COG1126	abc transporter atp-binding protein
H2866_RS18400	COG0765	amino acid transport
H2866_RS18405	COG1285	pathogenesis
H2866_RS18410	COG3042	response to heat
H2866_RS18420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2866_RS18425	COG2911	Protein conserved in bacteria
H2866_RS18435	COG3784	Protein of unknown function (DUF1318)
H2866_RS18445	COG1643	Atp-dependent helicase
H2866_RS18450	COG3591	Belongs to the peptidase S1B family
H2866_RS18460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H2866_RS18465	COG2205	protein histidine kinase activity
H2866_RS18470	COG0745	RESPONSE REGULATOR receiver
H2866_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS18490	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H2866_RS18495	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H2866_RS18500	COG0589	response to stress
H2866_RS18510	COG1215	transferase activity, transferring glycosyl groups
H2866_RS18520	COG2840	Smr protein MutS2
H2866_RS18525	COG1477	protein flavinylation
H2866_RS18540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2866_RS18555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS18560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2866_RS18575	COG0583	DNA-binding transcription factor activity
H2866_RS18585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2866_RS18590	COG4774	siderophore transport
H2866_RS18610	COG3842	ATPase activity
H2866_RS18615	COG1840	ABC-type Fe3 transport system, periplasmic component
H2866_RS18640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2866_RS18645	COG0583	DNA-binding transcription factor activity
H2866_RS18655	COG2814	Major facilitator Superfamily
H2866_RS18660	COG2188	Transcriptional regulator
H2866_RS18680	COG0583	DNA-binding transcription factor activity
H2866_RS18685	COG2072	flavoprotein involved in K transport
H2866_RS18700	COG1126	abc transporter atp-binding protein
H2866_RS18705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS18710	COG0765	amino acid transport
H2866_RS18715	COG0765	amino acid transport
H2866_RS18730	COG0436	Aminotransferase
H2866_RS18735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H2866_RS18740	COG1984	allophanate hydrolase subunit 2
H2866_RS18750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H2866_RS18755	COG4221	oxidoreductase activity
H2866_RS18760	COG0765	amino acid transport
H2866_RS18765	COG0765	amino acid transport
H2866_RS18775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS18780	COG3708	Transcriptional regulator
H2866_RS18780	COG2207	Transcriptional regulator
H2866_RS18785	COG2207	Transcriptional regulator
H2866_RS18800	COG0673	inositol 2-dehydrogenase activity
H2866_RS18810	COG2755	lipolytic protein G-D-S-L family
H2866_RS18810	COG0657	acetylesterase activity
H2866_RS18825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2866_RS18830	COG2011	ABC-type metal ion transport system permease component
H2866_RS18850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2866_RS18855	COG1121	(ABC) transporter
H2866_RS18865	COG0583	DNA-binding transcription factor activity
H2866_RS18870	COG1012	belongs to the aldehyde dehydrogenase family
H2866_RS18880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2866_RS18900	COG3842	ATPase activity
H2866_RS18905	COG1653	transport
H2866_RS18910	COG1175	transmembrane transport
H2866_RS18955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS18965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS18975	COG1609	Transcriptional regulator
H2866_RS18985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2866_RS18990	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2866_RS18995	COG2723	6-phospho-beta-galactosidase activity
H2866_RS19000	COG2723	6-phospho-beta-galactosidase activity
H2866_RS19010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H2866_RS19015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS19025	COG1126	abc transporter atp-binding protein
H2866_RS19035	COG2079	MmgE PrpD family protein
H2866_RS19040	COG1473	amidohydrolase
H2866_RS19045	COG0456	acetyltransferase
H2866_RS19050	COG0371	Dehydrogenase
H2866_RS19055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS19060	COG1942	4-Oxalocrotonate Tautomerase
H2866_RS19065	COG0038	chloride channel
H2866_RS19070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2866_RS19075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2866_RS19080	COG0306	phosphate transporter
H2866_RS19085	COG2814	Major facilitator Superfamily
H2866_RS19095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2866_RS19100	COG3424	synthase
H2866_RS19105	COG1024	Enoyl-CoA hydratase
H2866_RS19110	COG1024	Enoyl-CoA hydratase
H2866_RS19115	COG1024	Enoyl-CoA hydratase
H2866_RS19130	COG0583	DNA-binding transcription factor activity
H2866_RS19145	COG1538	Outer membrane efflux protein
H2866_RS19165	COG0561	phosphatase activity
H2866_RS19170	COG0277	FAD linked oxidase domain protein
H2866_RS19180	COG1321	iron dependent repressor
H2866_RS19200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2866_RS19205	COG0477	Major facilitator Superfamily
H2866_RS19220	COG4221	oxidoreductase activity
H2866_RS19235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2866_RS19240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS19245	COG3459	Glycosyltransferase 36 associated
H2866_RS19250	COG0697	spore germination
H2866_RS19255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2866_RS19270	COG2807	transmembrane transport
H2866_RS19280	COG4172	Belongs to the ABC transporter superfamily
H2866_RS19285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS19295	COG0747	negative chemotaxis
H2866_RS19310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2866_RS19320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS19325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS19330	COG0765	amino acid transport
H2866_RS19335	COG1126	abc transporter atp-binding protein
H2866_RS19340	COG0243	molybdopterin cofactor binding
H2866_RS19360	COG1968	undecaprenyl-diphosphatase activity
H2866_RS19365	COG3443	Belongs to the bacterial solute-binding protein 9 family
H2866_RS19370	COG3291	Pkd domain containing protein
H2866_RS19395	COG3284	Transcriptional regulator
H2866_RS19400	COG1116	anion transmembrane transporter activity
H2866_RS19410	COG3158	transport of potassium into the cell
H2866_RS19435	COG0371	Dehydrogenase
H2866_RS19450	COG3097	Belongs to the UPF0267 family
H2866_RS19475	COG2818	Glycosylase
H2866_RS19480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2866_RS19490	COG1840	ABC-type Fe3 transport system, periplasmic component
H2866_RS19495	COG4149	molybdate abc transporter
H2866_RS19515	COG0583	DNA-binding transcription factor activity
H2866_RS19530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H2866_RS19545	COG0402	S-adenosylhomocysteine deaminase activity
H2866_RS19565	COG0477	Major facilitator Superfamily
H2866_RS19570	COG0667	Aldo Keto reductase
H2866_RS19575	COG4221	oxidoreductase activity
H2866_RS19580	COG1742	UPF0060 membrane protein
H2866_RS19595	COG0477	Major facilitator Superfamily
H2866_RS19605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H2866_RS19615	COG1940	carbohydrate kinase activity
H2866_RS19620	COG0583	DNA-binding transcription factor activity
H2866_RS19625	COG2814	Major facilitator Superfamily
H2866_RS19635	COG0114	fumarate hydratase activity
H2866_RS19640	COG1733	regulation of RNA biosynthetic process
H2866_RS19645	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2866_RS19655	COG5339	Protein conserved in bacteria
H2866_RS19660	COG1609	Transcriptional regulator
H2866_RS19665	COG1263	PTS System
H2866_RS19665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2866_RS19670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2866_RS19675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2866_RS19680	COG0673	inositol 2-dehydrogenase activity
H2866_RS19685	COG1414	Transcriptional regulator
H2866_RS19690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2866_RS19695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2866_RS19700	COG0183	Belongs to the thiolase family
H2866_RS19705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2866_RS19710	COG4948	Mandelate Racemase Muconate Lactonizing
H2866_RS19730	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H2866_RS19755	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS19760	COG1129	ABC transporter
H2866_RS19765	COG1879	ABC-type sugar transport system periplasmic component
H2866_RS19785	COG4657	Part of a membrane complex involved in electron transport
H2866_RS19790	COG2878	Part of a membrane complex involved in electron transport
H2866_RS19795	COG4656	Part of a membrane complex involved in electron transport
H2866_RS19800	COG4658	electron transport chain
H2866_RS19805	COG4659	FMN binding
H2866_RS19815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2866_RS19845	COG0243	molybdopterin cofactor binding
H2866_RS19855	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H2866_RS19860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2866_RS19865	COG4619	ABC transporter
H2866_RS19870	COG0390	transport system, permease component
H2866_RS19875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2866_RS19890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2866_RS19905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H2866_RS19905	COG2010	Cytochrome c
H2866_RS19920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H2866_RS19920	COG3608	succinylglutamate desuccinylase aspartoacylase
H2866_RS19925	COG0667	Aldo Keto reductase
H2866_RS19930	COG2079	MmgE PrpD family protein
H2866_RS19955	COG0765	amino acid transport
H2866_RS19960	COG0165	Argininosuccinate lyase
H2866_RS19975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H2866_RS19980	COG2986	histidine ammonia-lyase
H2866_RS20005	COG0402	S-adenosylhomocysteine deaminase activity
H2866_RS20015	COG1228	amidohydrolase
H2866_RS20025	COG2186	Transcriptional regulator
H2866_RS20030	COG2271	Major facilitator Superfamily
H2866_RS20035	COG1312	Catalyzes the dehydration of D-mannonate
H2866_RS20045	COG1486	melibiose metabolic process
H2866_RS20050	COG2223	nitrite transmembrane transporter activity
H2866_RS20060	COG0747	negative chemotaxis
H2866_RS20065	COG0601	transmembrane transport
H2866_RS20070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS20075	COG0444	Belongs to the ABC transporter superfamily
H2866_RS20100	COG1105	Belongs to the carbohydrate kinase PfkB family
H2866_RS20120	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS20130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2866_RS20160	COG4608	Belongs to the ABC transporter superfamily
H2866_RS20165	COG0444	Belongs to the ABC transporter superfamily
H2866_RS20170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS20175	COG0601	transmembrane transport
H2866_RS20215	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H2866_RS20220	COG1522	sequence-specific DNA binding
H2866_RS20230	COG1473	amidohydrolase
H2866_RS20235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2866_RS20240	COG0454	-acetyltransferase
H2866_RS20245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2866_RS20250	COG4172	Belongs to the ABC transporter superfamily
H2866_RS20255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS20260	COG0601	transmembrane transport
H2866_RS20270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2866_RS20325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2866_RS20355	COG4572	Cation transport regulator
H2866_RS20360	COG0387	Pfam Sodium calcium exchanger
H2866_RS20365	COG1702	phosphate starvation-inducible protein PhoH
H2866_RS20385	COG0583	DNA-binding transcription factor activity
H2866_RS20400	COG0601	transmembrane transport
H2866_RS20405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS20420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2866_RS20425	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2866_RS20425	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2866_RS20425	COG0506	proline dehydrogenase activity
H2866_RS20435	COG1126	abc transporter atp-binding protein
H2866_RS20440	COG0765	amino acid transport
H2866_RS20445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS20455	COG2723	6-phospho-beta-galactosidase activity
H2866_RS20460	COG1263	PTS System
H2866_RS20460	COG2190	(PTS) system
H2866_RS20460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2866_RS20465	COG1914	H( )-stimulated, divalent metal cation uptake system
H2866_RS20470	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H2866_RS20485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2866_RS20490	COG1177	transmembrane transport
H2866_RS20495	COG1176	ABC-type spermidine putrescine transport system, permease component I
H2866_RS20500	COG3842	ATPase activity
H2866_RS20505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H2866_RS20515	COG0189	ligase activity
H2866_RS20520	COG0778	Nitroreductase
H2866_RS20540	COG0569	domain protein
H2866_RS20540	COG2985	domain, Protein
H2866_RS20575	COG2197	response regulator
H2866_RS20580	COG5002	protein histidine kinase activity
H2866_RS20580	COG0784	Response regulator, receiver
H2866_RS20580	COG2205	protein histidine kinase activity
H2866_RS20635	COG0741	lytic transglycosylase activity
H2866_RS20745	COG0625	glutathione transferase activity
H2866_RS20760	COG0671	phosphoesterase, PA-phosphatase related
H2866_RS20765	COG1686	Belongs to the peptidase S11 family
H2866_RS20790	COG2133	pyrroloquinoline quinone binding
H2866_RS20800	COG1380	Effector of murein hydrolase LrgA
H2866_RS20805	COG1346	cytolysis
H2866_RS20810	COG1473	amidohydrolase
H2866_RS20830	COG0791	NLP P60 protein
H2866_RS20835	COG1609	Transcriptional regulator
H2866_RS20845	COG0765	amino acid transport
H2866_RS20850	COG1126	abc transporter atp-binding protein
H2866_RS20865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2866_RS20870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2866_RS20875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2866_RS20880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2866_RS20885	COG0131	Imidazoleglycerol-phosphate dehydratase
H2866_RS20885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H2866_RS20905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2866_RS20905	COG0140	phosphoribosyl-ATP diphosphatase activity
H2866_RS20910	COG1215	transferase activity, transferring glycosyl groups
H2866_RS20915	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H2866_RS20920	COG0438	transferase activity, transferring glycosyl groups
H2866_RS20935	COG1442	glycosyl transferase family 8
H2866_RS20950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2866_RS20955	COG1253	flavin adenine dinucleotide binding
H2866_RS20960	COG2982	Protein involved in outer membrane biogenesis
H2866_RS20965	COG0717	Belongs to the dCTP deaminase family
H2866_RS20970	COG0572	uridine kinase
H2866_RS20975	COG0489	protein tyrosine kinase activity
H2866_RS20980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2866_RS20980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2866_RS20985	COG1979	alcohol dehydrogenase
H2866_RS21000	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H2866_RS21005	COG0765	amino acid transport
H2866_RS21010	COG0765	amino acid transport
H2866_RS21025	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS21030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2866_RS21035	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2866_RS21040	COG1129	ABC transporter
H2866_RS21050	COG1879	ABC-type sugar transport system periplasmic component
H2866_RS21055	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS21060	COG3958	Transketolase
H2866_RS21065	COG3959	Transketolase, thiamine diphosphate binding domain
H2866_RS21080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2866_RS21090	COG4221	oxidoreductase activity
H2866_RS21110	COG3708	Transcriptional regulator
H2866_RS21110	COG2207	Transcriptional regulator
H2866_RS21125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2866_RS21130	COG2814	Major facilitator Superfamily
H2866_RS21150	COG1088	dTDP-glucose 4,6-dehydratase activity
H2866_RS21155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H2866_RS21170	COG1215	transferase activity, transferring glycosyl groups
H2866_RS21220	COG0076	glutamate decarboxylase activity
H2866_RS21225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2866_RS21240	COG1309	transcriptional regulator
H2866_RS21250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H2866_RS21255	COG0640	Transcriptional regulator
H2866_RS21260	COG0583	DNA-binding transcription factor activity
H2866_RS21265	COG2059	Chromate
H2866_RS21285	COG2814	Major facilitator Superfamily
H2866_RS21300	COG3842	ATPase activity
H2866_RS21305	COG1376	ErfK ybiS ycfS ynhG family protein
H2866_RS21310	COG0436	Aminotransferase
H2866_RS21335	COG1309	transcriptional regulator
H2866_RS21350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS21360	COG0601	transmembrane transport
H2866_RS21365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS21375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS21385	COG0747	negative chemotaxis
H2866_RS21390	COG0601	transmembrane transport
H2866_RS21405	COG1464	Belongs to the NlpA lipoprotein family
H2866_RS21410	COG0778	Nitroreductase
H2866_RS21415	COG0765	amino acid transport
H2866_RS21420	COG0765	amino acid transport
H2866_RS21430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS21445	COG3387	PFAM Glycoside hydrolase 15-related
H2866_RS21490	COG1609	Transcriptional regulator
H2866_RS21495	COG1472	Belongs to the glycosyl hydrolase 3 family
H2866_RS21500	COG0667	Aldo Keto reductase
H2866_RS21525	COG0583	DNA-binding transcription factor activity
H2866_RS21530	COG1113	amino acid transport
H2866_RS21535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2866_RS21585	COG0625	glutathione transferase activity
H2866_RS21590	COG0583	DNA-binding transcription factor activity
H2866_RS21605	COG1309	transcriptional regulator
H2866_RS21635	COG2140	Oxalate decarboxylase
H2866_RS21650	COG0697	spore germination
H2866_RS21660	COG0523	cobalamin synthesis protein
H2866_RS21665	COG4702	Belongs to the UPF0303 family
H2866_RS21670	COG1082	Xylose isomerase domain protein TIM barrel
H2866_RS21675	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2866_RS21710	COG2814	Major facilitator Superfamily
H2866_RS21720	COG2011	ABC-type metal ion transport system permease component
H2866_RS21745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS21755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2866_RS21765	COG1116	anion transmembrane transporter activity
H2866_RS21790	COG1733	regulation of RNA biosynthetic process
H2866_RS21795	COG0583	DNA-binding transcription factor activity
H2866_RS21800	COG1028	Short-chain dehydrogenase reductase Sdr
H2866_RS21805	COG1971	Probably functions as a manganese efflux pump
H2866_RS21815	COG1309	transcriptional regulator
H2866_RS21830	COG0477	Major facilitator Superfamily
H2866_RS21835	COG1917	Cupin 2, conserved barrel domain protein
H2866_RS21835	COG2207	Transcriptional regulator
H2866_RS21860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2866_RS21865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2866_RS21870	COG0583	DNA-binding transcription factor activity
H2866_RS21875	COG2814	Major facilitator Superfamily
H2866_RS21880	COG1309	transcriptional regulator
H2866_RS21885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2866_RS21895	COG1566	PFAM secretion protein HlyD family protein
H2866_RS21900	COG2814	Major facilitator Superfamily
H2866_RS21910	COG0598	Magnesium transport protein CorA
H2866_RS21915	COG1196	nuclear chromosome segregation
H2866_RS21915	COG3264	Mechanosensitive ion channel
H2866_RS21925	COG2733	membrane
H2866_RS21945	COG0076	glutamate decarboxylase activity
H2866_RS21970	COG1064	alcohol dehydrogenase
H2866_RS21980	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2866_RS22015	COG3479	Phenolic acid decarboxylase
H2866_RS22020	COG0596	Alpha beta hydrolase
H2866_RS22025	COG3228	Belongs to the MtfA family
H2866_RS22045	COG0488	(ABC) transporter
H2866_RS22050	COG5383	Protein conserved in bacteria
H2866_RS22055	COG4221	oxidoreductase activity
H2866_RS22065	COG1122	ATPase activity
H2866_RS22070	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H2866_RS22075	COG1268	BioY protein
H2866_RS22090	COG0318	PFAM AMP-dependent synthetase and ligase
H2866_RS22095	COG0183	Belongs to the thiolase family
H2866_RS22100	COG1024	Enoyl-CoA hydratase
H2866_RS22110	COG0583	DNA-binding transcription factor activity
H2866_RS22130	COG0601	transmembrane transport
H2866_RS22155	COG4172	Belongs to the ABC transporter superfamily
H2866_RS22160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS22165	COG0601	transmembrane transport
H2866_RS22175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2866_RS22180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS22190	COG0765	amino acid transport
H2866_RS22195	COG1126	abc transporter atp-binding protein
H2866_RS22215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2866_RS22220	COG1070	Carbohydrate kinase
H2866_RS22235	COG1802	Transcriptional regulator
H2866_RS22240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2866_RS22245	COG0765	amino acid transport
H2866_RS22255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2866_RS22265	COG0006	proline dipeptidase activity
H2866_RS22270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2866_RS22275	COG0504	CTP synthase activity
H2866_RS22280	COG0436	Aminotransferase
H2866_RS22330	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H2866_RS22335	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H2866_RS22355	COG0246	Mannitol dehydrogenase
H2866_RS22360	COG1070	Carbohydrate kinase
H2866_RS22380	COG0113	porphobilinogen synthase activity
H2866_RS22385	COG4172	Belongs to the ABC transporter superfamily
H2866_RS22395	COG1940	carbohydrate kinase activity
H2866_RS22400	COG0747	negative chemotaxis
H2866_RS22405	COG0601	transmembrane transport
H2866_RS22410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2866_RS22420	COG0789	Transcriptional regulator
H2866_RS22425	COG0300	oxidoreductase activity
H2866_RS22430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H2866_RS22435	COG0583	DNA-binding transcription factor activity
H2866_RS22445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2866_RS22445	COG0473	3-isopropylmalate dehydrogenase activity
H2866_RS22455	COG2814	Major facilitator Superfamily
H2866_RS22510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2866_RS22520	COG0640	Transcriptional regulator
H2866_RS22550	COG0693	protein deglycase activity
H2866_RS22575	COG2814	Major facilitator Superfamily
H2866_RS22750	COG2211	Major facilitator Superfamily
H2866_RS22755	COG3250	beta-galactosidase activity
H2866_RS22785	COG2944	sequence-specific DNA binding
H2866_RS22905	COG0625	glutathione transferase activity
H2866_RS22910	COG0583	DNA-binding transcription factor activity
H2866_RS22920	COG1902	pentaerythritol trinitrate reductase activity
H2866_RS22940	COG1522	sequence-specific DNA binding
H2866_RS22945	COG0583	DNA-binding transcription factor activity
H2866_RS22950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2866_RS22955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2866_RS22955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2866_RS22995	COG0583	DNA-binding transcription factor activity
H2866_RS23055	COG0640	Transcriptional regulator
H2866_RS23060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2866_RS23070	COG0640	Transcriptional regulator
H2866_RS23100	COG0693	protein deglycase activity
H2866_RS23130	COG2814	Major facilitator Superfamily
H2866_RS23185	COG0640	Transcriptional regulator
H2866_RS23295	COG3549	Plasmid maintenance system killer
H2866_RS23300	COG3093	addiction module antidote protein HigA
H2866_RS23425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2866_RS23490	COG0640	Transcriptional regulator
H2866_RS23495	COG0431	NADPH-dependent FMN reductase