locus-tag	class	description
RGE_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RGE_RS00020	COG0592	DNA-directed DNA polymerase activity
RGE_RS00055	COG3550	peptidyl-serine autophosphorylation
RGE_RS00060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RGE_RS00075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS00100	COG3046	protein related to deoxyribodipyrimidine photolyase
RGE_RS00110	COG0612	Peptidase, M16
RGE_RS00160	COG2030	dehydratase
RGE_RS00175	COG0653	protein targeting
RGE_RS00185	COG3045	CreA protein
RGE_RS00195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RGE_RS00200	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RGE_RS00230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RGE_RS00240	COG4555	ABC transporter
RGE_RS00245	COG1668	transmembrane transport
RGE_RS00270	COG0445	tRNA wobble uridine modification
RGE_RS00275	COG0357	Ribosomal RNA small subunit methyltransferase G
RGE_RS00280	COG1192	Involved in chromosome partitioning
RGE_RS00290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RGE_RS00300	COG1475	DNA binding
RGE_RS00305	COG2766	serine protein kinase
RGE_RS00310	COG2718	Belongs to the UPF0229 family
RGE_RS00315	COG2719	SpoVR family
RGE_RS00320	COG0277	FAD linked oxidase domain protein
RGE_RS00330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RGE_RS00335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RGE_RS00340	COG0312	modulator of DNA gyrase
RGE_RS00355	COG0792	nuclease activity
RGE_RS00360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RGE_RS00370	COG2084	Dehydrogenase
RGE_RS00380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGE_RS00410	COG3118	belongs to the thioredoxin family
RGE_RS00415	COG3181	Tripartite tricarboxylate transporter family receptor
RGE_RS00425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RGE_RS00435	COG0840	transmembrane signaling receptor activity
RGE_RS00440	COG0783	Belongs to the Dps family
RGE_RS00445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RGE_RS00455	COG1573	uracil-dna glycosylase
RGE_RS00465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RGE_RS00475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RGE_RS00485	COG0343	queuine tRNA-ribosyltransferase activity
RGE_RS00495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RGE_RS00500	COG1902	pentaerythritol trinitrate reductase activity
RGE_RS00510	COG2258	MOSC domain
RGE_RS00515	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RGE_RS00540	COG0443	Heat shock 70 kDa protein
RGE_RS00560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGE_RS00565	COG1116	anion transmembrane transporter activity
RGE_RS00565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGE_RS00575	COG1272	protein, Hemolysin III
RGE_RS00590	COG2233	PERMEase
RGE_RS00605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RGE_RS00610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RGE_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS00630	COG3246	L-lysine catabolic process to acetate
RGE_RS00655	COG0583	DNA-binding transcription factor activity
RGE_RS00660	COG2851	Citrate transporter
RGE_RS00675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RGE_RS00680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RGE_RS00690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RGE_RS00695	COG0183	Belongs to the thiolase family
RGE_RS00705	COG2814	Major facilitator Superfamily
RGE_RS00710	COG1607	acyl-coa hydrolase
RGE_RS00725	COG1250	3-hydroxyacyl-CoA dehydrogenase
RGE_RS00735	COG2271	Major facilitator Superfamily
RGE_RS00750	COG3245	cytochrome
RGE_RS00775	COG0784	Response regulator, receiver
RGE_RS00775	COG2205	protein histidine kinase activity
RGE_RS00775	COG5002	protein histidine kinase activity
RGE_RS00790	COG2205	protein histidine kinase activity
RGE_RS00790	COG2202	Pas domain
RGE_RS00825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RGE_RS00830	COG0477	Major facilitator Superfamily
RGE_RS00840	COG0745	RESPONSE REGULATOR receiver
RGE_RS00845	COG0386	Belongs to the glutathione peroxidase family
RGE_RS00855	COG0583	DNA-binding transcription factor activity
RGE_RS00870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGE_RS00885	COG0444	Belongs to the ABC transporter superfamily
RGE_RS00890	COG4608	Belongs to the ABC transporter superfamily
RGE_RS00895	COG0747	negative chemotaxis
RGE_RS00900	COG0154	amidase activity
RGE_RS00920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RGE_RS00930	COG1595	DNA-templated transcription, initiation
RGE_RS00940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RGE_RS00945	COG4977	sequence-specific DNA binding
RGE_RS00955	COG0697	spore germination
RGE_RS00960	COG0247	lactate metabolic process
RGE_RS00970	COG0277	FAD linked oxidase domain protein
RGE_RS00975	COG0277	FAD linked oxidase domain protein
RGE_RS01020	COG0616	signal peptide processing
RGE_RS01030	COG0586	Pfam SNARE associated Golgi protein
RGE_RS01040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RGE_RS01045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RGE_RS01075	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RGE_RS01075	COG3608	succinylglutamate desuccinylase aspartoacylase
RGE_RS01085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RGE_RS01090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RGE_RS01095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RGE_RS01100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RGE_RS01105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RGE_RS01110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RGE_RS01120	COG0356	it plays a direct role in the translocation of protons across the membrane
RGE_RS01135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RGE_RS01165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RGE_RS01170	COG0384	phenazine biosynthesis protein PhzF
RGE_RS01175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGE_RS01185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGE_RS01195	COG0488	(ABC) transporter
RGE_RS01200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RGE_RS01205	COG0189	ligase activity
RGE_RS01210	COG3135	benzoate transporter
RGE_RS01215	COG3158	transport of potassium into the cell
RGE_RS01225	COG0004	ammonium transporteR
RGE_RS01230	COG0347	Belongs to the P(II) protein family
RGE_RS01235	COG0606	chelatase, subunit chli
RGE_RS01240	COG1410	methionine synthase
RGE_RS01240	COG0646	methionine synthase
RGE_RS01265	COG0366	Alpha amylase catalytic
RGE_RS01270	COG3833	ABC-type maltose transport systems, permease component
RGE_RS01275	COG1175	transmembrane transport
RGE_RS01285	COG3842	ATPase activity
RGE_RS01295	COG0366	Alpha amylase catalytic
RGE_RS01305	COG0210	DNA helicase
RGE_RS01315	COG3279	Response regulator of the LytR AlgR family
RGE_RS01320	COG2972	Histidine kinase
RGE_RS01325	COG0583	DNA-binding transcription factor activity
RGE_RS01345	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RGE_RS01375	COG1522	sequence-specific DNA binding
RGE_RS01395	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RGE_RS01405	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RGE_RS01420	COG2967	ApaG domain
RGE_RS01425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RGE_RS01480	COG0546	phosphoglycolate phosphatase activity
RGE_RS01495	COG0512	Glutamine amidotransferase of anthranilate synthase
RGE_RS01500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RGE_RS01505	COG0134	indole-3-glycerol-phosphate synthase activity
RGE_RS01510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RGE_RS01550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RGE_RS01555	COG0081	regulation of translation
RGE_RS01560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RGE_RS01565	COG0222	ribosome binding
RGE_RS01570	COG0085	RNA polymerase activity
RGE_RS01575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RGE_RS01585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RGE_RS01590	COG0049	tRNA binding
RGE_RS01595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RGE_RS01605	COG0051	transcription antitermination factor activity, RNA binding
RGE_RS01610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RGE_RS01615	COG0088	Forms part of the polypeptide exit tunnel
RGE_RS01620	COG0089	rRNA binding
RGE_RS01625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RGE_RS01630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RGE_RS01635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RGE_RS01640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RGE_RS01645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RGE_RS01650	COG0255	Belongs to the universal ribosomal protein uL29 family
RGE_RS01655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RGE_RS01660	COG0678	peroxiredoxin activity
RGE_RS01665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RGE_RS01670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RGE_RS01675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RGE_RS01680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RGE_RS01685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RGE_RS01690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RGE_RS01695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RGE_RS01700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RGE_RS01705	COG1841	ribosomal large subunit assembly
RGE_RS01710	COG0200	Binds to the 23S rRNA
RGE_RS01715	COG0201	protein transport
RGE_RS01720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RGE_RS01725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RGE_RS01730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RGE_RS01735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RGE_RS01740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RGE_RS01745	COG0202	RNA polymerase activity
RGE_RS01750	COG0203	ribosomal protein L17
RGE_RS01765	COG1022	Amp-dependent synthetase and ligase
RGE_RS01780	COG0577	efflux transmembrane transporter activity
RGE_RS01785	COG1136	(ABC) transporter
RGE_RS01790	COG1819	glycosyl
RGE_RS01820	COG1404	Belongs to the peptidase S8 family
RGE_RS01830	COG2199	diguanylate cyclase activity
RGE_RS01830	COG2200	EAL domain
RGE_RS01830	COG2203	Gaf domain
RGE_RS01835	COG1858	cytochrome C peroxidase
RGE_RS01840	COG0392	lysyltransferase activity
RGE_RS01845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RGE_RS01850	COG3568	Endonuclease Exonuclease Phosphatase
RGE_RS01855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RGE_RS01855	COG5322	oxidoreductase activity
RGE_RS01860	COG1454	alcohol dehydrogenase
RGE_RS01875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RGE_RS01875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RGE_RS01880	COG0826	peptidase U32
RGE_RS01885	COG0826	peptidase U32
RGE_RS01890	COG3154	lipid carrier protein
RGE_RS01905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RGE_RS01910	COG3243	poly(R)-hydroxyalkanoic acid synthase
RGE_RS01920	COG0709	Synthesizes selenophosphate from selenide and ATP
RGE_RS01925	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RGE_RS01930	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RGE_RS01940	COG3639	organic phosphonate transmembrane transporter activity
RGE_RS01950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGE_RS01985	COG2204	response regulator
RGE_RS01995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RGE_RS02010	COG0489	protein tyrosine kinase activity
RGE_RS02020	COG3409	Peptidoglycan-binding domain 1 protein
RGE_RS02020	COG3267	Type II secretory pathway component ExeA
RGE_RS02040	COG0438	transferase activity, transferring glycosyl groups
RGE_RS02055	COG0438	transferase activity, transferring glycosyl groups
RGE_RS02060	COG0367	asparagine synthase
RGE_RS02065	COG0297	glycogen (starch) synthase activity
RGE_RS02070	COG0438	transferase activity, transferring glycosyl groups
RGE_RS02105	COG0438	transferase activity, transferring glycosyl groups
RGE_RS02115	COG1216	Glycosyl transferase, family 2
RGE_RS02120	COG1215	transferase activity, transferring glycosyl groups
RGE_RS02125	COG1215	transferase activity, transferring glycosyl groups
RGE_RS02145	COG0438	transferase activity, transferring glycosyl groups
RGE_RS02160	COG1216	Glycosyl transferase, family 2
RGE_RS02215	COG1862	Preprotein translocase
RGE_RS02220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGE_RS02225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGE_RS02235	COG2922	Belongs to the Smg family
RGE_RS02240	COG0758	DNA mediated transformation
RGE_RS02250	COG0242	peptide deformylase activity
RGE_RS02255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RGE_RS02280	COG0126	phosphoglycerate kinase activity
RGE_RS02290	COG0469	pyruvate kinase activity
RGE_RS02300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RGE_RS02310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RGE_RS02315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RGE_RS02320	COG0009	L-threonylcarbamoyladenylate synthase
RGE_RS02345	COG2027	D-alanyl-D-alanine carboxypeptidase
RGE_RS02350	COG1214	PFAM Peptidase M22, glycoprotease
RGE_RS02360	COG1573	uracil-dna glycosylase
RGE_RS02365	COG2205	protein histidine kinase activity
RGE_RS02370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RGE_RS02385	COG0037	tRNA processing
RGE_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS02410	COG0617	tRNA 3'-terminal CCA addition
RGE_RS02420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGE_RS02430	COG0583	DNA-binding transcription factor activity
RGE_RS02450	COG1404	Belongs to the peptidase S8 family
RGE_RS02455	COG3047	cAMP biosynthetic process
RGE_RS02460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RGE_RS02465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RGE_RS02485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RGE_RS02495	COG0745	RESPONSE REGULATOR receiver
RGE_RS02515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RGE_RS02525	COG1560	Kdo2-lipid A biosynthetic process
RGE_RS02530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RGE_RS02540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RGE_RS02555	COG1522	sequence-specific DNA binding
RGE_RS02570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RGE_RS02595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGE_RS02605	COG0477	Major facilitator Superfamily
RGE_RS02615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RGE_RS02625	COG2116	formate transmembrane transporter activity
RGE_RS02635	COG0179	Fumarylacetoacetate (FAA) hydrolase
RGE_RS02645	COG0737	Belongs to the 5'-nucleotidase family
RGE_RS02670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RGE_RS02675	COG4452	Inner membrane protein CreD
RGE_RS02680	COG2205	protein histidine kinase activity
RGE_RS02685	COG0745	RESPONSE REGULATOR receiver
RGE_RS02695	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS02705	COG2731	YhcH YjgK YiaL family protein
RGE_RS02715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGE_RS02720	COG1802	Transcriptional regulator
RGE_RS02765	COG1215	transferase activity, transferring glycosyl groups
RGE_RS02870	COG0583	DNA-binding transcription factor activity
RGE_RS02875	COG1380	Effector of murein hydrolase LrgA
RGE_RS02885	COG0803	Belongs to the bacterial solute-binding protein 9 family
RGE_RS02895	COG1121	(ABC) transporter
RGE_RS02905	COG1785	Belongs to the alkaline phosphatase family
RGE_RS02925	COG4771	TonB-dependent receptor
RGE_RS02935	COG2375	cellular response to nickel ion
RGE_RS02935	COG1132	(ABC) transporter
RGE_RS02940	COG1132	(ABC) transporter
RGE_RS02945	COG4774	siderophore transport
RGE_RS02950	COG2900	Belongs to the SlyX family
RGE_RS02965	COG0318	PFAM AMP-dependent synthetase and ligase
RGE_RS02990	COG4771	TonB-dependent receptor
RGE_RS02995	COG1429	ligase activity, forming nitrogen-metal bonds
RGE_RS03055	COG0500	methyltransferase
RGE_RS03065	COG0789	Transcriptional regulator
RGE_RS03135	COG0789	Transcriptional regulator
RGE_RS03205	COG1024	Enoyl-CoA hydratase
RGE_RS03215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGE_RS03230	COG0583	DNA-binding transcription factor activity
RGE_RS03240	COG2151	metal-sulfur cluster biosynthetic enzyme
RGE_RS03245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RGE_RS03245	COG1648	precorrin-2 dehydrogenase activity
RGE_RS03265	COG3391	amine dehydrogenase activity
RGE_RS03270	COG1522	sequence-specific DNA binding
RGE_RS03285	COG0535	radical SAM domain protein
RGE_RS03300	COG0024	Methionine aminopeptidase
RGE_RS03315	COG0596	Alpha beta hydrolase
RGE_RS03320	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RGE_RS03340	COG2205	protein histidine kinase activity
RGE_RS03345	COG0840	transmembrane signaling receptor activity
RGE_RS03370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RGE_RS03375	COG1518	maintenance of DNA repeat elements
RGE_RS03390	COG1857	crispr-associated protein
RGE_RS03410	COG1595	DNA-templated transcription, initiation
RGE_RS03420	COG4206	TonB-dependent receptor
RGE_RS03445	COG0154	amidase activity
RGE_RS03450	COG0840	transmembrane signaling receptor activity
RGE_RS03455	COG0835	chemotaxis
RGE_RS03460	COG0840	transmembrane signaling receptor activity
RGE_RS03480	COG0814	amino acid
RGE_RS03485	COG1760	l-serine dehydratase
RGE_RS03500	COG1569	PIN domain
RGE_RS03505	COG3311	Transcriptional regulator
RGE_RS03525	COG0714	Associated with various cellular activities
RGE_RS03530	COG3256	nitric oxide reductase
RGE_RS03535	COG2010	Cytochrome c
RGE_RS03570	COG1012	belongs to the aldehyde dehydrogenase family
RGE_RS03580	COG1072	(Pantothenic acid kinase))
RGE_RS03610	COG4999	Histidine kinase
RGE_RS03610	COG3850	Histidine kinase
RGE_RS03610	COG3437	response regulator, receiver
RGE_RS03610	COG2205	protein histidine kinase activity
RGE_RS03615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGE_RS03620	COG0642	Histidine kinase
RGE_RS03635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RGE_RS03650	COG0205	6-phosphofructokinase activity
RGE_RS03665	COG0583	DNA-binding transcription factor activity
RGE_RS03695	COG0326	Molecular chaperone. Has ATPase activity
RGE_RS03720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RGE_RS03725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RGE_RS03730	COG0316	Belongs to the HesB IscA family
RGE_RS03735	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RGE_RS03740	COG0739	heme binding
RGE_RS03745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RGE_RS03750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RGE_RS03755	COG1490	D-aminoacyl-tRNA deacylase activity
RGE_RS03805	COG1022	Amp-dependent synthetase and ligase
RGE_RS03810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGE_RS03815	COG0612	Peptidase, M16
RGE_RS03820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RGE_RS03835	COG1136	(ABC) transporter
RGE_RS03850	COG0628	permease
RGE_RS03855	COG1752	Esterase of the alpha-beta hydrolase superfamily
RGE_RS03860	COG5001	Diguanylate cyclase
RGE_RS03865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RGE_RS03875	COG0840	transmembrane signaling receptor activity
RGE_RS03880	COG0840	transmembrane signaling receptor activity
RGE_RS03885	COG0840	transmembrane signaling receptor activity
RGE_RS03890	COG1459	type II secretion system
RGE_RS03925	COG4795	General secretion pathway protein
RGE_RS03935	COG1053	succinate dehydrogenase
RGE_RS03950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RGE_RS03955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RGE_RS03965	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RGE_RS03970	COG0601	transmembrane transport
RGE_RS03975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGE_RS03985	COG4608	Belongs to the ABC transporter superfamily
RGE_RS03995	COG1965	Belongs to the frataxin family
RGE_RS04035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RGE_RS04040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RGE_RS04045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RGE_RS04055	COG0067	glutamate synthase
RGE_RS04055	COG0070	glutamate synthase
RGE_RS04055	COG0069	glutamate synthase activity
RGE_RS04065	COG1127	ABC transporter
RGE_RS04070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RGE_RS04075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RGE_RS04080	COG2853	Lipoprotein
RGE_RS04100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RGE_RS04110	COG3409	Peptidoglycan-binding domain 1 protein
RGE_RS04110	COG3267	Type II secretory pathway component ExeA
RGE_RS04115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RGE_RS04120	COG0166	Belongs to the GPI family
RGE_RS04140	COG1473	amidohydrolase
RGE_RS04145	COG0243	molybdopterin cofactor binding
RGE_RS04180	COG1131	(ABC) transporter
RGE_RS04185	COG0842	Transport permease protein
RGE_RS04190	COG0740	serine-type endopeptidase activity
RGE_RS04200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RGE_RS04205	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RGE_RS04210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RGE_RS04215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RGE_RS04220	COG0131	Imidazoleglycerol-phosphate dehydratase
RGE_RS04225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RGE_RS04230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RGE_RS04235	COG0107	imidazoleglycerol-phosphate synthase activity
RGE_RS04240	COG0742	ribosomal rna small subunit methyltransferase
RGE_RS04245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RGE_RS04250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RGE_RS04260	COG0193	aminoacyl-tRNA hydrolase activity
RGE_RS04265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RGE_RS04270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RGE_RS04280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RGE_RS04285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RGE_RS04295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RGE_RS04315	COG1660	Displays ATPase and GTPase activities
RGE_RS04320	COG0497	DNA recombination
RGE_RS04325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RGE_RS04330	COG1420	regulation of RNA biosynthetic process
RGE_RS04360	COG0549	Belongs to the carbamate kinase family
RGE_RS04365	COG0477	Major facilitator Superfamily
RGE_RS04370	COG2271	Major facilitator Superfamily
RGE_RS04375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RGE_RS04380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RGE_RS04390	COG0583	DNA-binding transcription factor activity
RGE_RS04425	COG3275	phosphorelay sensor kinase activity
RGE_RS04445	COG2205	protein histidine kinase activity
RGE_RS04450	COG0745	RESPONSE REGULATOR receiver
RGE_RS04455	COG1695	Transcriptional regulator
RGE_RS04495	COG1960	acyl-CoA dehydrogenase activity
RGE_RS04505	COG1024	Enoyl-CoA hydratase
RGE_RS04505	COG1250	3-hydroxyacyl-CoA dehydrogenase
RGE_RS04510	COG0183	Belongs to the thiolase family
RGE_RS04515	COG1024	Enoyl-CoA hydratase
RGE_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS04530	COG2119	membrane
RGE_RS04560	COG1607	acyl-coa hydrolase
RGE_RS04565	COG5265	(ABC) transporter
RGE_RS04570	COG0583	DNA-binding transcription factor activity
RGE_RS04575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGE_RS04580	COG0765	amino acid transport
RGE_RS04585	COG0765	amino acid transport
RGE_RS04590	COG1126	abc transporter atp-binding protein
RGE_RS04605	COG0418	dihydroorotase activity
RGE_RS04615	COG0501	Belongs to the peptidase M48B family
RGE_RS04625	COG2814	Major facilitator Superfamily
RGE_RS04640	COG2001	Belongs to the MraZ family
RGE_RS04645	COG0275	rRNA processing
RGE_RS04660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RGE_RS04665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RGE_RS04670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RGE_RS04675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RGE_RS04685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RGE_RS04690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RGE_RS04695	COG1181	Belongs to the D-alanine--D-alanine ligase family
RGE_RS04700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RGE_RS04710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RGE_RS04715	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RGE_RS04715	COG1672	PFAM Archaeal ATPase
RGE_RS04740	COG2885	chlorophyll binding
RGE_RS04750	COG3181	Tripartite tricarboxylate transporter family receptor
RGE_RS04790	COG5507	3-demethylubiquinone-9 3-methyltransferase
RGE_RS04795	COG0667	Aldo Keto reductase
RGE_RS04805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RGE_RS04840	COG2204	response regulator
RGE_RS04845	COG3852	Histidine kinase
RGE_RS04850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RGE_RS04860	COG2031	fatty acid transporter
RGE_RS04865	COG0183	Belongs to the thiolase family
RGE_RS04870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RGE_RS04875	COG0280	phosphate acetyltransferase
RGE_RS04875	COG0857	belongs to the CobB CobQ family
RGE_RS04895	COG1473	amidohydrolase
RGE_RS04900	COG1522	sequence-specific DNA binding
RGE_RS04935	COG0840	transmembrane signaling receptor activity
RGE_RS04940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RGE_RS04950	COG3267	Type II secretory pathway component ExeA
RGE_RS04950	COG3409	Peptidoglycan-binding domain 1 protein
RGE_RS04955	COG0412	Dienelactone hydrolase
RGE_RS04960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RGE_RS04975	COG2197	response regulator
RGE_RS04995	COG0138	bifunctional purine biosynthesis protein purh
RGE_RS05010	COG1238	metal cluster binding
RGE_RS05015	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RGE_RS05030	COG1230	cation diffusion facilitator family transporter
RGE_RS05035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RGE_RS05065	COG0494	nUDIX hydrolase
RGE_RS05070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RGE_RS05075	COG0140	phosphoribosyl-ATP diphosphatase activity
RGE_RS05090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RGE_RS05095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RGE_RS05100	COG0805	protein transport
RGE_RS05105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGE_RS05110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RGE_RS05115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RGE_RS05125	COG1970	mechanosensitive ion channel activity
RGE_RS05130	COG0723	plastoquinol--plastocyanin reductase activity
RGE_RS05135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RGE_RS05140	COG2857	Cytochrome c1
RGE_RS05145	COG0625	glutathione transferase activity
RGE_RS05150	COG2969	positive regulation of protein catabolic process
RGE_RS05165	COG0653	protein targeting
RGE_RS05170	COG1404	Belongs to the peptidase S8 family
RGE_RS05175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RGE_RS05185	COG0584	glycerophosphoryl diester phosphodiesterase
RGE_RS05195	COG0395	ABC-type sugar transport system, permease component
RGE_RS05200	COG1175	transmembrane transport
RGE_RS05205	COG1653	transport
RGE_RS05225	COG2226	methyltransferase
RGE_RS05240	COG1596	polysaccharide export
RGE_RS05245	COG3944	biosynthesis protein
RGE_RS05250	COG0489	protein tyrosine kinase activity
RGE_RS05250	COG3206	protein involved in exopolysaccharide biosynthesis
RGE_RS05290	COG0438	transferase activity, transferring glycosyl groups
RGE_RS05325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RGE_RS05335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RGE_RS05345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RGE_RS05360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RGE_RS05370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RGE_RS05375	COG0494	nUDIX hydrolase
RGE_RS05385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RGE_RS05390	COG0747	negative chemotaxis
RGE_RS05395	COG0601	transmembrane transport
RGE_RS05400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGE_RS05405	COG0444	Belongs to the ABC transporter superfamily
RGE_RS05410	COG4608	Belongs to the ABC transporter superfamily
RGE_RS05420	COG1793	dna ligase
RGE_RS05420	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RGE_RS05425	COG1042	CoA-binding domain protein
RGE_RS05425	COG0045	succinate-CoA ligase (ADP-forming) activity
RGE_RS05425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RGE_RS05435	COG1793	dna ligase
RGE_RS05445	COG0823	Involved in the tonB-independent uptake of proteins
RGE_RS05460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RGE_RS05485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RGE_RS05495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RGE_RS05540	COG0657	acetylesterase activity
RGE_RS05560	COG0583	DNA-binding transcription factor activity
RGE_RS05565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RGE_RS05580	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RGE_RS05610	COG2864	formate dehydrogenase
RGE_RS05615	COG0437	4 iron, 4 sulfur cluster binding
RGE_RS05620	COG0243	molybdopterin cofactor binding
RGE_RS05620	COG3383	formate dehydrogenase (NAD+) activity
RGE_RS05625	COG0243	molybdopterin cofactor binding
RGE_RS05625	COG3383	formate dehydrogenase (NAD+) activity
RGE_RS05630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RGE_RS05635	COG1525	nuclease
RGE_RS05655	COG2040	homocysteine
RGE_RS05665	COG2832	Protein of unknown function (DUF454)
RGE_RS05680	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
RGE_RS05715	COG4771	TonB-dependent receptor
RGE_RS05725	COG0583	DNA-binding transcription factor activity
RGE_RS05765	COG1393	Belongs to the ArsC family
RGE_RS05770	COG4335	DNA alkylation repair
RGE_RS05775	COG0307	riboflavin synthase, alpha
RGE_RS05800	COG3284	Transcriptional regulator
RGE_RS05810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RGE_RS05835	COG3547	Transposase (IS116 IS110 IS902 family)
RGE_RS05850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RGE_RS05890	COG2200	EAL domain
RGE_RS05925	COG0625	glutathione transferase activity
RGE_RS05940	COG2925	Exonuclease
RGE_RS05945	COG2272	Belongs to the type-B carboxylesterase lipase family
RGE_RS05985	COG0039	L-malate dehydrogenase activity
RGE_RS06000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RGE_RS06005	COG1053	succinate dehydrogenase
RGE_RS06010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RGE_RS06015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RGE_RS06020	COG0372	Belongs to the citrate synthase family
RGE_RS06030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RGE_RS06035	COG0045	succinate-CoA ligase (ADP-forming) activity
RGE_RS06040	COG1802	Transcriptional regulator
RGE_RS06050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RGE_RS06050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RGE_RS06055	COG1703	isobutyryl-CoA mutase activity
RGE_RS06060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RGE_RS06065	COG4770	biotin carboxylase activity
RGE_RS06070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RGE_RS06090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RGE_RS06100	COG0066	3-isopropylmalate dehydratase activity
RGE_RS06105	COG0473	3-isopropylmalate dehydrogenase activity
RGE_RS06110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RGE_RS06120	COG0101	tRNA pseudouridine synthase activity
RGE_RS06125	COG0135	phosphoribosylanthranilate isomerase activity
RGE_RS06130	COG0133	tryptophan synthase activity
RGE_RS06135	COG0159	tryptophan synthase activity
RGE_RS06140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RGE_RS06145	COG0285	dihydrofolate synthase activity
RGE_RS06155	COG1286	toxin biosynthetic process
RGE_RS06160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RGE_RS06170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RGE_RS06215	COG1132	(ABC) transporter
RGE_RS06275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RGE_RS06310	COG1051	belongs to the nudix hydrolase family
RGE_RS06355	COG0346	lactoylglutathione lyase activity
RGE_RS06370	COG0454	-acetyltransferase
RGE_RS06370	COG0456	acetyltransferase
RGE_RS06380	COG1742	UPF0060 membrane protein
RGE_RS06390	COG0454	-acetyltransferase
RGE_RS06410	COG0765	amino acid transport
RGE_RS06415	COG0765	amino acid transport
RGE_RS06420	COG1968	undecaprenyl-diphosphatase activity
RGE_RS06435	COG0587	DNA-directed DNA polymerase activity
RGE_RS06440	COG0400	carboxylic ester hydrolase activity
RGE_RS06445	COG3022	response to hydroperoxide
RGE_RS06465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RGE_RS06490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RGE_RS06500	COG0515	serine threonine protein kinase
RGE_RS06500	COG2815	serine threonine protein kinase
RGE_RS06515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RGE_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS06535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RGE_RS06540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RGE_RS06550	COG0268	Binds directly to 16S ribosomal RNA
RGE_RS06555	COG0728	peptidoglycan biosynthetic process
RGE_RS06560	COG2912	Transglutaminase-like superfamily
RGE_RS06565	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RGE_RS06575	COG0617	tRNA 3'-terminal CCA addition
RGE_RS06590	COG1392	Phosphate transport regulator
RGE_RS06595	COG0306	phosphate transporter
RGE_RS06610	COG0228	four-way junction DNA binding
RGE_RS06615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RGE_RS06620	COG0336	Belongs to the RNA methyltransferase TrmD family
RGE_RS06625	COG0335	large ribosomal subunit rRNA binding
RGE_RS06630	COG0494	nUDIX hydrolase
RGE_RS06635	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RGE_RS06640	COG1162	GTPase activity
RGE_RS06645	COG0501	Belongs to the peptidase M48B family
RGE_RS06650	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RGE_RS06665	COG0513	Belongs to the DEAD box helicase family
RGE_RS06675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RGE_RS06680	COG0583	DNA-binding transcription factor activity
RGE_RS06685	COG1741	Belongs to the pirin family
RGE_RS06695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RGE_RS06700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RGE_RS06735	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RGE_RS06740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RGE_RS06745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RGE_RS06785	COG1132	(ABC) transporter
RGE_RS06790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RGE_RS06810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RGE_RS06815	COG0287	Prephenate dehydrogenase
RGE_RS06840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RGE_RS06850	COG0697	spore germination
RGE_RS06870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RGE_RS06880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RGE_RS06890	COG0196	riboflavin kinase activity
RGE_RS06895	COG1187	pseudouridine synthase activity
RGE_RS06900	COG3191	aminopeptidase activity
RGE_RS06910	COG1960	acyl-CoA dehydrogenase activity
RGE_RS06915	COG3577	Aspartyl protease
RGE_RS06920	COG1666	GTP binding
RGE_RS06925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RGE_RS06950	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
RGE_RS06975	COG0205	6-phosphofructokinase activity
RGE_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS06995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RGE_RS07000	COG0564	pseudouridine synthase activity
RGE_RS07005	COG1162	GTPase activity
RGE_RS07025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RGE_RS07030	COG2918	glutathione biosynthetic process
RGE_RS07035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RGE_RS07055	COG0174	glutamine synthetase
RGE_RS07065	COG3852	Histidine kinase
RGE_RS07080	COG0626	cystathionine gamma-synthase activity
RGE_RS07110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RGE_RS07120	COG3437	response regulator, receiver
RGE_RS07125	COG1132	(ABC) transporter
RGE_RS07130	COG0427	acetyl-CoA hydrolase
RGE_RS07135	COG3706	GGDEF domain
RGE_RS07150	COG1136	(ABC) transporter
RGE_RS07155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RGE_RS07160	COG2814	Major facilitator Superfamily
RGE_RS07165	COG1187	pseudouridine synthase activity
RGE_RS07205	COG2186	Transcriptional regulator
RGE_RS07210	COG2610	gluconate transmembrane transporter activity
RGE_RS07215	COG2084	Dehydrogenase
RGE_RS07220	COG3395	kinase activity
RGE_RS07225	COG0235	Class ii aldolase
RGE_RS07230	COG3622	Belongs to the hyi family
RGE_RS07240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RGE_RS07260	COG0586	Pfam SNARE associated Golgi protein
RGE_RS07265	COG0860	N-Acetylmuramoyl-L-alanine amidase
RGE_RS07270	COG0802	atpase or kinase
RGE_RS07275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RGE_RS07295	COG4974	Belongs to the 'phage' integrase family
RGE_RS07305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RGE_RS07315	COG2095	MarC family integral membrane protein
RGE_RS07320	COG0765	amino acid transport
RGE_RS07335	COG2833	Protein of unknown function (DUF455)
RGE_RS07345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RGE_RS07360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RGE_RS07365	COG0148	phosphopyruvate hydratase activity
RGE_RS07375	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RGE_RS07380	COG0504	CTP synthase activity
RGE_RS07385	COG4206	TonB-dependent receptor
RGE_RS07395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RGE_RS07400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RGE_RS07410	COG1492	cobalamin metabolic process
RGE_RS07415	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RGE_RS07420	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RGE_RS07445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RGE_RS07450	COG0483	inositol monophosphate 1-phosphatase activity
RGE_RS07460	COG1045	serine acetyltransferase
RGE_RS07465	COG0521	Mo-molybdopterin cofactor biosynthetic process
RGE_RS07470	COG3028	Belongs to the UPF0307 family
RGE_RS07475	COG0312	modulator of DNA gyrase
RGE_RS07480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RGE_RS07485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RGE_RS07500	COG1610	YqeY-like protein
RGE_RS07505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RGE_RS07510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RGE_RS07520	COG0730	response to heat
RGE_RS07540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RGE_RS07545	COG2878	Part of a membrane complex involved in electron transport
RGE_RS07560	COG0556	nucleotide-excision repair
RGE_RS07565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RGE_RS07570	COG1959	2 iron, 2 sulfur cluster binding
RGE_RS07575	COG1104	cysteine desulfurase activity
RGE_RS07580	COG0822	iron-sulfur transferase activity
RGE_RS07595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RGE_RS07600	COG0443	Heat shock 70 kDa protein
RGE_RS07605	COG0633	Ferredoxin
RGE_RS07610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RGE_RS07615	COG0683	leucine binding
RGE_RS07625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RGE_RS07630	COG1185	polyribonucleotide nucleotidyltransferase activity
RGE_RS07635	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS07635	COG0604	alcohol dehydrogenase
RGE_RS07635	COG3321	synthase
RGE_RS07640	COG0149	triose-phosphate isomerase activity
RGE_RS07655	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGE_RS07660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGE_RS07665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGE_RS07670	COG0649	NAD binding
RGE_RS07675	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RGE_RS07680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RGE_RS07685	COG1034	ATP synthesis coupled electron transport
RGE_RS07690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RGE_RS07695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGE_RS07705	COG0713	ATP synthesis coupled electron transport
RGE_RS07720	COG1007	ATP synthesis coupled electron transport
RGE_RS07725	COG0494	nUDIX hydrolase
RGE_RS07735	COG0277	FAD linked oxidase domain protein
RGE_RS07745	COG1295	ribonuclease BN
RGE_RS07760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RGE_RS07765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RGE_RS07765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RGE_RS07775	COG2267	carboxylic ester hydrolase activity
RGE_RS07790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RGE_RS07795	COG2814	Major facilitator Superfamily
RGE_RS07815	COG3842	ATPase activity
RGE_RS07820	COG0395	ABC-type sugar transport system, permease component
RGE_RS07830	COG1653	transport
RGE_RS07835	COG1760	l-serine dehydratase
RGE_RS07840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RGE_RS07840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RGE_RS07845	COG0509	glycine decarboxylation via glycine cleavage system
RGE_RS07850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RGE_RS07855	COG0318	PFAM AMP-dependent synthetase and ligase
RGE_RS07860	COG1024	Enoyl-CoA hydratase
RGE_RS07875	COG0579	oxidoreductase
RGE_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS07885	COG3132	Protein of unknown function, DUF480
RGE_RS07920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RGE_RS07920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RGE_RS07925	COG1105	Belongs to the carbohydrate kinase PfkB family
RGE_RS07930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RGE_RS07930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RGE_RS07940	COG0167	dihydroorotate dehydrogenase activity
RGE_RS07945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RGE_RS07955	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RGE_RS07955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGE_RS07965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RGE_RS07975	COG0322	excinuclease ABC activity
RGE_RS08000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RGE_RS08070	COG4227	nucleotidyltransferase activity
RGE_RS08090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RGE_RS08135	COG0023	Translation Initiation Factor
RGE_RS08150	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
RGE_RS08160	COG0318	PFAM AMP-dependent synthetase and ligase
RGE_RS08165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RGE_RS08190	COG1722	exodeoxyribonuclease VII activity
RGE_RS08195	COG0142	geranyltranstransferase activity
RGE_RS08200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RGE_RS08205	COG1469	GTP cyclohydrolase I activity
RGE_RS08230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RGE_RS08255	COG1157	protein secretion by the type III secretion system
RGE_RS08270	COG1766	The M ring may be actively involved in energy transduction
RGE_RS08280	COG5001	Diguanylate cyclase
RGE_RS08280	COG3300	MHYT domain
RGE_RS08295	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RGE_RS08310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RGE_RS08315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RGE_RS08320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RGE_RS08325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RGE_RS08370	COG0562	UDP-galactopyranose mutase
RGE_RS08395	COG1360	Flagellar Motor Protein
RGE_RS08400	COG0745	RESPONSE REGULATOR receiver
RGE_RS08410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RGE_RS08415	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RGE_RS08430	COG1191	sigma factor activity
RGE_RS08440	COG4191	Histidine kinase
RGE_RS08460	COG1815	bacterial-type flagellum-dependent cell motility
RGE_RS08465	COG1558	bacterial-type flagellum-dependent cell motility
RGE_RS08470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RGE_RS08520	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RGE_RS08525	COG1706	bacterial-type flagellum-dependent cell motility
RGE_RS08530	COG1705	Flagellar rod assembly protein muramidase FlgJ
RGE_RS08530	COG3951	Flagellar rod assembly protein muramidase FlgJ
RGE_RS08535	COG1256	bacterial-type flagellum assembly
RGE_RS08540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RGE_RS08545	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RGE_RS08585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RGE_RS08590	COG1280	lysine exporter protein (LysE YggA)
RGE_RS08605	COG1966	Carbon starvation protein
RGE_RS08610	COG1882	Formate acetyltransferase
RGE_RS08615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RGE_RS08625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RGE_RS08630	COG2116	formate transmembrane transporter activity
RGE_RS08645	COG3279	Response regulator of the LytR AlgR family
RGE_RS08650	COG3275	phosphorelay sensor kinase activity
RGE_RS08660	COG0840	transmembrane signaling receptor activity
RGE_RS08665	COG0840	transmembrane signaling receptor activity
RGE_RS08670	COG0840	transmembrane signaling receptor activity
RGE_RS08675	COG0840	transmembrane signaling receptor activity
RGE_RS08680	COG0129	dihydroxy-acid dehydratase activity
RGE_RS08695	COG1869	D-ribose catabolic process
RGE_RS08700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGE_RS08705	COG1609	Transcriptional regulator
RGE_RS08710	COG1172	Belongs to the binding-protein-dependent transport system permease family
RGE_RS08715	COG1129	ABC transporter
RGE_RS08720	COG1879	ABC-type sugar transport system periplasmic component
RGE_RS08725	COG2801	Transposase and inactivated derivatives
RGE_RS08725	COG3415	Transposase
RGE_RS08830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RGE_RS08845	COG0587	DNA-directed DNA polymerase activity
RGE_RS08905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RGE_RS08910	COG1253	flavin adenine dinucleotide binding
RGE_RS08925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RGE_RS08990	COG0842	Transport permease protein
RGE_RS08995	COG0842	Transport permease protein
RGE_RS08995	COG1129	ABC transporter
RGE_RS09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS09015	COG3290	protein histidine kinase activity
RGE_RS09025	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RGE_RS09030	COG0308	aminopeptidase N
RGE_RS09035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RGE_RS09040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RGE_RS09070	COG0667	Aldo Keto reductase
RGE_RS09085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RGE_RS09090	COG0251	oxidation-reduction process
RGE_RS09100	COG0009	L-threonylcarbamoyladenylate synthase
RGE_RS09115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RGE_RS09125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RGE_RS09130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RGE_RS09150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RGE_RS09150	COG1648	precorrin-2 dehydrogenase activity
RGE_RS09175	COG2099	Precorrin-6x reductase
RGE_RS09190	COG2875	Belongs to the precorrin methyltransferase family
RGE_RS09195	COG1797	cobyrinic acid a,c-diamide synthase activity
RGE_RS09200	COG0784	Response regulator, receiver
RGE_RS09200	COG2198	Histidine kinase
RGE_RS09200	COG2205	protein histidine kinase activity
RGE_RS09205	COG0583	DNA-binding transcription factor activity
RGE_RS09270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RGE_RS09275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RGE_RS09320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RGE_RS09370	COG4263	nitrous-oxide reductase activity
RGE_RS09375	COG3245	cytochrome
RGE_RS09415	COG1131	(ABC) transporter
RGE_RS09420	COG0842	Transport permease protein
RGE_RS09425	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RGE_RS09430	COG4585	Histidine kinase
RGE_RS09435	COG2197	response regulator
RGE_RS09460	COG0569	domain protein
RGE_RS09460	COG2985	domain, Protein
RGE_RS09465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RGE_RS09470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RGE_RS09475	COG1584	GPR1 FUN34 yaaH family protein
RGE_RS09480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RGE_RS09485	COG1607	acyl-coa hydrolase
RGE_RS09490	COG0583	DNA-binding transcription factor activity
RGE_RS09495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RGE_RS09530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RGE_RS09535	COG1684	flagellar biosynthetic protein fliR
RGE_RS09540	COG1987	bacterial-type flagellum assembly
RGE_RS09550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RGE_RS09615	COG1191	sigma factor activity
RGE_RS09620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RGE_RS09625	COG1360	Flagellar Motor Protein
RGE_RS09650	COG1815	bacterial-type flagellum-dependent cell motility
RGE_RS09655	COG1558	bacterial-type flagellum-dependent cell motility
RGE_RS09675	COG4786	Flagellar basal body rod
RGE_RS09685	COG1706	bacterial-type flagellum-dependent cell motility
RGE_RS09700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RGE_RS09715	COG3181	Tripartite tricarboxylate transporter family receptor
RGE_RS09725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RGE_RS09730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGE_RS09745	COG1739	Uncharacterized protein family UPF0029
RGE_RS09755	COG2843	Capsule synthesis protein
RGE_RS09765	COG1271	oxidase subunit
RGE_RS09770	COG1294	oxidase, subunit
RGE_RS09785	COG0626	cystathionine gamma-synthase activity
RGE_RS09800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RGE_RS09805	COG1045	serine acetyltransferase
RGE_RS09815	COG2205	protein histidine kinase activity
RGE_RS09815	COG0784	Response regulator, receiver
RGE_RS09875	COG0446	pyridine nucleotide-disulphide oxidoreductase
RGE_RS09900	COG3381	protein complex oligomerization
RGE_RS09905	COG3302	dmso reductase anchor subunit
RGE_RS09910	COG0437	4 iron, 4 sulfur cluster binding
RGE_RS09915	COG0243	molybdopterin cofactor binding
RGE_RS09920	COG0840	transmembrane signaling receptor activity
RGE_RS09975	COG0733	neurotransmitter:sodium symporter activity
RGE_RS10005	COG4191	Histidine kinase
RGE_RS10005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGE_RS10050	COG2205	protein histidine kinase activity
RGE_RS10060	COG3002	Belongs to the UPF0753 family
RGE_RS10065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RGE_RS10070	COG0583	DNA-binding transcription factor activity
RGE_RS10080	COG0745	RESPONSE REGULATOR receiver
RGE_RS10085	COG2205	protein histidine kinase activity
RGE_RS10090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RGE_RS10095	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RGE_RS10100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RGE_RS10110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RGE_RS10120	COG1733	regulation of RNA biosynthetic process
RGE_RS10125	COG0798	PFAM Bile acid sodium symporter
RGE_RS10135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RGE_RS10145	COG2226	methyltransferase
RGE_RS10165	COG4771	TonB-dependent receptor
RGE_RS10180	COG0693	protein deglycase activity
RGE_RS10185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RGE_RS10190	COG2011	ABC-type metal ion transport system permease component
RGE_RS10195	COG1464	Belongs to the NlpA lipoprotein family
RGE_RS10200	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
RGE_RS10215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RGE_RS10220	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
RGE_RS10220	COG2878	Part of a membrane complex involved in electron transport
RGE_RS10225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RGE_RS10225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RGE_RS10225	COG0674	pyruvate-flavodoxin oxidoreductase activity
RGE_RS10225	COG1013	pyruvate-flavodoxin oxidoreductase activity
RGE_RS10230	COG4656	Part of a membrane complex involved in electron transport
RGE_RS10235	COG4658	electron transport chain
RGE_RS10240	COG4659	FMN binding
RGE_RS10245	COG4660	Part of a membrane complex involved in electron transport
RGE_RS10250	COG4657	Part of a membrane complex involved in electron transport
RGE_RS10270	COG3108	Peptidase M15
RGE_RS10280	COG0183	Belongs to the thiolase family
RGE_RS10285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RGE_RS10290	COG1960	acyl-CoA dehydrogenase activity
RGE_RS10295	COG3550	peptidyl-serine autophosphorylation
RGE_RS10300	COG1960	acyl-CoA dehydrogenase activity
RGE_RS10310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RGE_RS10320	COG2205	protein histidine kinase activity
RGE_RS10320	COG0784	Response regulator, receiver
RGE_RS10330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RGE_RS10330	COG0574	Belongs to the PEP-utilizing enzyme family
RGE_RS10355	COG4977	sequence-specific DNA binding
RGE_RS10360	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RGE_RS10375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RGE_RS10380	COG1053	succinate dehydrogenase
RGE_RS10385	COG2204	response regulator
RGE_RS10400	COG2226	methyltransferase
RGE_RS10420	COG1959	2 iron, 2 sulfur cluster binding
RGE_RS10435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RGE_RS10445	COG0723	plastoquinol--plastocyanin reductase activity
RGE_RS10465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RGE_RS10470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RGE_RS10475	COG1505	serine-type exopeptidase activity
RGE_RS10490	COG0339	signal peptide processing
RGE_RS10495	COG2202	Pas domain
RGE_RS10495	COG2205	protein histidine kinase activity
RGE_RS10505	COG2972	Histidine kinase
RGE_RS10515	COG0613	PHP domain protein
RGE_RS10520	COG1136	(ABC) transporter
RGE_RS10535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RGE_RS10545	COG2304	oxidoreductase activity
RGE_RS10555	COG0714	Associated with various cellular activities
RGE_RS10560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGE_RS10565	COG0084	hydrolase, TatD family'
RGE_RS10585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RGE_RS10600	COG2814	Major facilitator Superfamily
RGE_RS10625	COG3864	Putative metallopeptidase domain
RGE_RS10660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS10670	COG1183	phosphatidylcholine synthase activity
RGE_RS10705	COG0071	Belongs to the small heat shock protein (HSP20) family
RGE_RS10740	COG4133	protoheme IX ABC transporter activity
RGE_RS10770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RGE_RS10780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RGE_RS10785	COG3088	subunit of a heme lyase
RGE_RS10810	COG0583	DNA-binding transcription factor activity
RGE_RS10815	COG2814	Major facilitator Superfamily
RGE_RS10830	COG1011	Hydrolase
RGE_RS10865	COG0729	surface antigen
RGE_RS10870	COG0668	transmembrane transport
RGE_RS10880	COG1404	Belongs to the peptidase S8 family
RGE_RS10885	COG0514	ATP-dependent DNA helicase (RecQ)
RGE_RS10905	COG0033	Phosphoglucomutase
RGE_RS10930	COG1301	dicarboxylic acid transport
RGE_RS11025	COG0469	pyruvate kinase activity
RGE_RS11030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RGE_RS11080	COG2124	cytochrome p450
RGE_RS11085	COG5002	protein histidine kinase activity
RGE_RS11085	COG0784	Response regulator, receiver
RGE_RS11090	COG0745	RESPONSE REGULATOR receiver
RGE_RS11095	COG4191	Histidine kinase
RGE_RS11120	COG0840	transmembrane signaling receptor activity
RGE_RS11135	COG0840	transmembrane signaling receptor activity
RGE_RS11150	COG1408	metallophosphoesterase
RGE_RS11205	COG0840	transmembrane signaling receptor activity
RGE_RS11210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RGE_RS11220	COG3040	lipid binding
RGE_RS11230	COG1064	alcohol dehydrogenase
RGE_RS11245	COG2205	protein histidine kinase activity
RGE_RS11250	COG2194	sulfuric ester hydrolase activity
RGE_RS11260	COG3493	citrate carrier protein
RGE_RS11270	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RGE_RS11275	COG3052	prosthetic group binding
RGE_RS11295	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
RGE_RS11340	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
RGE_RS11345	COG0784	Response regulator, receiver
RGE_RS11345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGE_RS11345	COG2198	Histidine kinase
RGE_RS11345	COG2205	protein histidine kinase activity
RGE_RS11375	COG0714	Associated with various cellular activities
RGE_RS11385	COG3851	Histidine kinase
RGE_RS11405	COG0492	ferredoxin-NADP+ reductase activity
RGE_RS11415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RGE_RS11420	COG0175	sulfate reduction
RGE_RS11435	COG1752	Esterase of the alpha-beta hydrolase superfamily
RGE_RS11450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RGE_RS11460	COG0123	including yeast histone deacetylase and acetoin utilization protein
RGE_RS11465	COG1250	3-hydroxyacyl-CoA dehydrogenase
RGE_RS11465	COG0824	Thioesterase
RGE_RS11480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RGE_RS11480	COG1877	trehalose-phosphatase activity
RGE_RS11510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RGE_RS11515	COG4566	intracellular signal transduction
RGE_RS11520	COG4191	Histidine kinase
RGE_RS11530	COG0508	dehydrogenase complex catalyzes the overall conversion of
RGE_RS11535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RGE_RS11545	COG3300	MHYT domain
RGE_RS11545	COG5001	Diguanylate cyclase
RGE_RS11560	COG0625	glutathione transferase activity
RGE_RS11570	COG3243	poly(R)-hydroxyalkanoic acid synthase
RGE_RS11575	COG0183	Belongs to the thiolase family
RGE_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS11600	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
RGE_RS11610	COG0024	Methionine aminopeptidase
RGE_RS11615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RGE_RS11615	COG0047	phosphoribosylformylglycinamidine synthase activity
RGE_RS11620	COG0488	(ABC) transporter
RGE_RS11635	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RGE_RS11645	COG0583	DNA-binding transcription factor activity
RGE_RS11655	COG1960	acyl-CoA dehydrogenase activity
RGE_RS11660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RGE_RS11680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RGE_RS11690	COG1764	response to oxidative stress
RGE_RS11695	COG1846	Transcriptional regulator
RGE_RS11700	COG0488	(ABC) transporter
RGE_RS11705	COG2890	protein-(glutamine-N5) methyltransferase activity
RGE_RS11710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RGE_RS11720	COG2171	N-acyltransferase activity
RGE_RS11730	COG0183	Belongs to the thiolase family
RGE_RS11740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RGE_RS11745	COG1196	nuclear chromosome segregation
RGE_RS11755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RGE_RS11760	COG0242	peptide deformylase activity
RGE_RS11775	COG4181	ATPase activity
RGE_RS11790	COG0842	Transport permease protein
RGE_RS11795	COG1131	(ABC) transporter
RGE_RS11810	COG0488	(ABC) transporter
RGE_RS11815	COG0513	Belongs to the DEAD box helicase family
RGE_RS11825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RGE_RS11830	COG0271	Belongs to the BolA IbaG family
RGE_RS11835	COG2917	probably involved in intracellular septation
RGE_RS11840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RGE_RS11845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RGE_RS11880	COG0183	Belongs to the thiolase family
RGE_RS11885	COG1960	acyl-CoA dehydrogenase activity
RGE_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS11900	COG2130	NADP-dependent
RGE_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS11925	COG2183	response to ionizing radiation
RGE_RS11930	COG3416	Protein conserved in bacteria
RGE_RS11930	COG2943	transferase activity, transferring hexosyl groups
RGE_RS11935	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RGE_RS11945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RGE_RS11950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RGE_RS11955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RGE_RS11960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RGE_RS11965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RGE_RS11970	COG0072	phenylalanine-tRNA ligase activity
RGE_RS11970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGE_RS11975	COG0776	regulation of translation
RGE_RS11990	COG2197	response regulator
RGE_RS12055	COG2204	response regulator
RGE_RS12060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGE_RS12070	COG0438	transferase activity, transferring glycosyl groups
RGE_RS12090	COG0859	PFAM glycosyl transferase family 9
RGE_RS12100	COG2192	nodulation
RGE_RS12105	COG0859	PFAM glycosyl transferase family 9
RGE_RS12110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RGE_RS12115	COG0438	transferase activity, transferring glycosyl groups
RGE_RS12120	COG1335	isochorismatase
RGE_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS12185	COG2261	transglycosylase associated protein
RGE_RS12205	COG2323	membrane
RGE_RS12225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RGE_RS12240	COG2823	Periplasmic or secreted lipoprotein
RGE_RS12255	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RGE_RS12270	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RGE_RS12275	COG2721	sulfolactate sulfo-lyase activity
RGE_RS12280	COG2721	sulfolactate sulfo-lyase activity
RGE_RS12285	COG4771	TonB-dependent receptor
RGE_RS12290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGE_RS12295	COG0641	radical SAM
RGE_RS12310	COG2391	methyltransferase activity
RGE_RS12325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RGE_RS12330	COG4521	taurine ABC transporter
RGE_RS12335	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RGE_RS12340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGE_RS12350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGE_RS12365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGE_RS12370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGE_RS12375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGE_RS12385	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RGE_RS12405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGE_RS12410	COG0765	amino acid transport
RGE_RS12415	COG0765	amino acid transport
RGE_RS12435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RGE_RS12440	COG0435	Glutathione S-transferase
RGE_RS12445	COG4771	TonB-dependent receptor
RGE_RS12450	COG2814	Major facilitator Superfamily
RGE_RS12470	COG5632	N-Acetylmuramoyl-L-alanine amidase
RGE_RS12470	COG3409	Peptidoglycan-binding domain 1 protein
RGE_RS12480	COG3039	Transposase
RGE_RS12670	COG0084	hydrolase, TatD family'
RGE_RS12685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RGE_RS12690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RGE_RS12695	COG0354	folic acid binding
RGE_RS12710	COG0657	acetylesterase activity
RGE_RS12720	COG0039	L-malate dehydrogenase activity
RGE_RS12725	COG2224	Isocitrate lyase
RGE_RS12735	COG0010	Belongs to the arginase family
RGE_RS12750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RGE_RS12755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGE_RS12760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RGE_RS12765	COG0174	glutamine synthetase
RGE_RS12775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RGE_RS12780	COG3842	ATPase activity
RGE_RS12785	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGE_RS12790	COG1177	transmembrane transport
RGE_RS12800	COG1012	belongs to the aldehyde dehydrogenase family
RGE_RS12810	COG0697	spore germination
RGE_RS12820	COG0235	Class ii aldolase
RGE_RS12825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RGE_RS12830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RGE_RS12835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RGE_RS12840	COG0596	Alpha beta hydrolase
RGE_RS12845	COG2267	carboxylic ester hydrolase activity
RGE_RS12910	COG0517	IMP dehydrogenase activity
RGE_RS12935	COG0583	DNA-binding transcription factor activity
RGE_RS12975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGE_RS12985	COG1960	acyl-CoA dehydrogenase activity
RGE_RS12995	COG1349	DNA-binding transcription factor activity
RGE_RS13005	COG0741	lytic transglycosylase activity
RGE_RS13020	COG4948	Mandelate Racemase Muconate Lactonizing
RGE_RS13030	COG0840	transmembrane signaling receptor activity
RGE_RS13050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RGE_RS13060	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS13080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RGE_RS13080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RGE_RS13085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RGE_RS13085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RGE_RS13090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RGE_RS13095	COG0560	Phosphoserine phosphatase
RGE_RS13100	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
RGE_RS13110	COG1643	Atp-dependent helicase
RGE_RS13120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RGE_RS13120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RGE_RS13125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RGE_RS13130	COG1840	ABC-type Fe3 transport system, periplasmic component
RGE_RS13140	COG3300	MHYT domain
RGE_RS13140	COG5001	Diguanylate cyclase
RGE_RS13165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RGE_RS13175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RGE_RS13180	COG0443	Heat shock 70 kDa protein
RGE_RS13185	COG0484	heat shock protein binding
RGE_RS13205	COG0359	binds to the 23S rRNA
RGE_RS13210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RGE_RS13215	COG2965	DNA replication, synthesis of RNA primer
RGE_RS13220	COG0360	Binds together with S18 to 16S ribosomal RNA
RGE_RS13225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RGE_RS13235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RGE_RS13240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGE_RS13245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RGE_RS13250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGE_RS13255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGE_RS13260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RGE_RS13265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGE_RS13280	COG0750	zinc metalloprotease
RGE_RS13285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RGE_RS13300	COG0233	cytoplasmic translational termination
RGE_RS13305	COG0528	UMP kinase activity
RGE_RS13310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RGE_RS13315	COG0052	Belongs to the universal ribosomal protein uS2 family
RGE_RS13325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGE_RS13330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RGE_RS13330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RGE_RS13335	COG0557	exoribonuclease II activity
RGE_RS13350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RGE_RS13355	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RGE_RS13365	COG0330	HflC and HflK could
RGE_RS13370	COG0330	HflC and HflK could
RGE_RS13375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RGE_RS13380	COG1923	regulation of RNA biosynthetic process
RGE_RS13385	COG1160	GTP binding
RGE_RS13390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RGE_RS13400	COG0124	histidyl-tRNA synthetase
RGE_RS13405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RGE_RS13420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RGE_RS13425	COG0105	UTP biosynthetic process
RGE_RS13430	COG1187	pseudouridine synthase activity
RGE_RS13435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RGE_RS13440	COG0564	pseudouridine synthase activity
RGE_RS13450	COG1199	ATP-dependent helicase activity
RGE_RS13470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RGE_RS13485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RGE_RS13495	COG0508	dehydrogenase complex catalyzes the overall conversion of
RGE_RS13500	COG0567	Dehydrogenase, E1 component
RGE_RS13515	COG1960	acyl-CoA dehydrogenase activity
RGE_RS13535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGE_RS13540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS13545	COG0577	efflux transmembrane transporter activity
RGE_RS13545	COG1136	(ABC) transporter
RGE_RS13550	COG1538	Outer membrane efflux protein
RGE_RS13555	COG2823	Periplasmic or secreted lipoprotein
RGE_RS13595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RGE_RS13600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RGE_RS13605	COG0740	serine-type endopeptidase activity
RGE_RS13610	COG0544	peptidyl-prolyl cis-trans isomerase activity
RGE_RS13625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS13635	COG1562	ergosterol biosynthetic process
RGE_RS13640	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RGE_RS13645	COG1414	Transcriptional regulator
RGE_RS13655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RGE_RS13660	COG1183	phosphatidylcholine synthase activity
RGE_RS13665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RGE_RS13670	COG0440	acetolactate synthase activity
RGE_RS13675	COG0028	Belongs to the TPP enzyme family
RGE_RS13710	COG0347	Belongs to the P(II) protein family
RGE_RS13715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RGE_RS13715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RGE_RS13725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RGE_RS13740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RGE_RS13750	COG1217	gtp-binding protein TYPA
RGE_RS13755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RGE_RS13760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RGE_RS13765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RGE_RS13770	COG2251	uridine kinase activity
RGE_RS13770	COG0195	Participates in both transcription termination and antitermination
RGE_RS13775	COG0779	Required for maturation of 30S ribosomal subunits
RGE_RS13830	COG0438	transferase activity, transferring glycosyl groups
RGE_RS13845	COG2207	Transcriptional regulator
RGE_RS13860	COG1242	4 iron, 4 sulfur cluster binding
RGE_RS13865	COG3001	Fructosamine kinase
RGE_RS13880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RGE_RS13890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RGE_RS13890	COG3008	intermembrane lipid transfer
RGE_RS13910	COG5487	UPF0391 membrane protein
RGE_RS13915	COG0114	fumarate hydratase activity
RGE_RS13925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RGE_RS13970	COG0674	pyruvate-flavodoxin oxidoreductase activity
RGE_RS13975	COG1013	pyruvate-flavodoxin oxidoreductase activity
RGE_RS14010	COG2814	Major facilitator Superfamily
RGE_RS14020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RGE_RS14025	COG3447	MASE1 domain protein
RGE_RS14025	COG5002	protein histidine kinase activity
RGE_RS14025	COG5001	Diguanylate cyclase
RGE_RS14035	COG3546	catalase activity
RGE_RS14045	COG0625	glutathione transferase activity
RGE_RS14050	COG4566	intracellular signal transduction
RGE_RS14065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RGE_RS14070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RGE_RS14085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RGE_RS14090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RGE_RS14100	COG0446	pyridine nucleotide-disulphide oxidoreductase
RGE_RS14120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RGE_RS14130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RGE_RS14150	COG0297	glycogen (starch) synthase activity
RGE_RS14155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RGE_RS14160	COG0058	SHG alpha-glucan phosphorylase activity
RGE_RS14165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RGE_RS14190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RGE_RS14195	COG0795	lipopolysaccharide-transporting ATPase activity
RGE_RS14210	COG0583	DNA-binding transcription factor activity
RGE_RS14215	COG0436	Aminotransferase
RGE_RS14245	COG0625	glutathione transferase activity
RGE_RS14265	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RGE_RS14290	COG1278	Cold shock
RGE_RS14310	COG4941	Belongs to the sigma-70 factor family
RGE_RS14325	COG3795	YCII-related domain
RGE_RS14345	COG0583	DNA-binding transcription factor activity
RGE_RS14380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RGE_RS14385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS14390	COG0745	RESPONSE REGULATOR receiver
RGE_RS14395	COG2205	protein histidine kinase activity
RGE_RS14400	COG0004	ammonium transporteR
RGE_RS14435	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS14440	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS14445	COG0583	DNA-binding transcription factor activity
RGE_RS14450	COG0025	NhaP-type Na H and K H
RGE_RS14460	COG3795	YCII-related domain
RGE_RS14465	COG4941	Belongs to the sigma-70 factor family
RGE_RS14510	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS14515	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS14525	COG0318	PFAM AMP-dependent synthetase and ligase
RGE_RS14560	COG2885	chlorophyll binding
RGE_RS14560	COG3047	cAMP biosynthetic process
RGE_RS14595	COG1475	DNA binding
RGE_RS14610	COG0582	viral genome integration into host DNA
RGE_RS14620	COG1522	sequence-specific DNA binding
RGE_RS14625	COG1794	racemase activity, acting on amino acids and derivatives
RGE_RS14650	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
RGE_RS14710	COG1022	Amp-dependent synthetase and ligase
RGE_RS14725	COG0840	transmembrane signaling receptor activity
RGE_RS14820	COG3712	iron ion homeostasis
RGE_RS14830	COG4774	siderophore transport
RGE_RS14840	COG1595	DNA-templated transcription, initiation
RGE_RS14850	COG3712	iron ion homeostasis
RGE_RS14855	COG1595	DNA-templated transcription, initiation
RGE_RS14860	COG4774	siderophore transport
RGE_RS14865	COG3712	iron ion homeostasis
RGE_RS14870	COG1595	DNA-templated transcription, initiation
RGE_RS14920	COG3712	iron ion homeostasis
RGE_RS14925	COG4774	siderophore transport
RGE_RS14960	COG0628	permease
RGE_RS14980	COG3135	benzoate transporter
RGE_RS14990	COG0840	transmembrane signaling receptor activity
RGE_RS14995	COG1733	regulation of RNA biosynthetic process
RGE_RS15005	COG0436	Aminotransferase
RGE_RS15010	COG0277	FAD linked oxidase domain protein
RGE_RS15015	COG1464	Belongs to the NlpA lipoprotein family
RGE_RS15020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RGE_RS15025	COG2011	ABC-type metal ion transport system permease component
RGE_RS15060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RGE_RS15060	COG0519	Catalyzes the synthesis of GMP from XMP
RGE_RS15080	COG2914	Belongs to the UPF0125 (RnfH) family
RGE_RS15085	COG2867	negative regulation of translational initiation
RGE_RS15090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RGE_RS15095	COG0346	lactoylglutathione lyase activity
RGE_RS15105	COG0626	cystathionine gamma-synthase activity
RGE_RS15110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RGE_RS15115	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RGE_RS15130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RGE_RS15180	COG1538	Outer membrane efflux protein
RGE_RS15205	COG1218	3'(2'),5'-bisphosphate nucleotidase
RGE_RS15210	COG0175	sulfate reduction
RGE_RS15220	COG0450	alkyl hydroperoxide reductase
RGE_RS15235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RGE_RS15260	COG2814	Major facilitator Superfamily
RGE_RS15300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RGE_RS15310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RGE_RS15315	COG1178	ABC-type Fe3 transport system permease component
RGE_RS15320	COG3842	ATPase activity
RGE_RS15325	COG1840	ABC-type Fe3 transport system, periplasmic component
RGE_RS15330	COG1802	Transcriptional regulator
RGE_RS15335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RGE_RS15385	COG0527	aspartate kinase activity
RGE_RS15390	COG0037	tRNA processing
RGE_RS15405	COG0215	cysteine-tRNA ligase activity
RGE_RS15425	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGE_RS15435	COG0542	response to heat
RGE_RS15440	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RGE_RS15445	COG1278	Cold shock
RGE_RS15455	COG0463	Glycosyl transferase, family 2
RGE_RS15480	COG0745	RESPONSE REGULATOR receiver
RGE_RS15500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGE_RS15505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGE_RS15540	COG3278	Belongs to the heme-copper respiratory oxidase family
RGE_RS15550	COG2217	Heavy metal translocating P-type atpase
RGE_RS15560	COG1570	exodeoxyribonuclease VII activity
RGE_RS15565	COG0811	peptide transport
RGE_RS15570	COG0848	biopolymer transport protein
RGE_RS15575	COG1663	tetraacyldisaccharide 4'-kinase activity
RGE_RS15580	COG2835	tetraacyldisaccharide 4'-kinase activity
RGE_RS15585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RGE_RS15590	COG0563	adenylate kinase activity
RGE_RS15605	COG4206	TonB-dependent receptor
RGE_RS15610	COG4172	Belongs to the ABC transporter superfamily
RGE_RS15615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGE_RS15620	COG0601	transmembrane transport
RGE_RS15630	COG1619	proteins homologs of microcin C7 resistance protein MccF
RGE_RS15675	COG2885	chlorophyll binding
RGE_RS15690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RGE_RS15695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS15705	COG4651	solute:proton antiporter activity
RGE_RS15705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RGE_RS15710	COG0657	acetylesterase activity
RGE_RS15715	COG0438	transferase activity, transferring glycosyl groups
RGE_RS15750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RGE_RS15755	COG1522	sequence-specific DNA binding
RGE_RS15760	COG0697	spore germination
RGE_RS15765	COG0028	Belongs to the TPP enzyme family
RGE_RS15780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RGE_RS15795	COG0840	transmembrane signaling receptor activity
RGE_RS15800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RGE_RS15805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RGE_RS15810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RGE_RS15815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RGE_RS15820	COG3265	gluconokinase activity
RGE_RS15825	COG1609	Transcriptional regulator
RGE_RS15835	COG0542	response to heat
RGE_RS15840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RGE_RS15845	COG0314	molybdopterin synthase activity
RGE_RS15850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RGE_RS15855	COG0303	'Molybdopterin
RGE_RS15870	COG0436	Aminotransferase
RGE_RS15880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RGE_RS15885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RGE_RS15890	COG1793	dna ligase
RGE_RS15900	COG0604	alcohol dehydrogenase
RGE_RS15905	COG0791	NLP P60 protein
RGE_RS15910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RGE_RS15915	COG0746	molybdenum cofactor guanylyltransferase activity
RGE_RS15925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RGE_RS15930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS15935	COG0328	RNA-DNA hybrid ribonuclease activity
RGE_RS15940	COG2226	methyltransferase
RGE_RS15945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGE_RS15950	COG0741	lytic transglycosylase activity
RGE_RS15950	COG1388	LysM domain
RGE_RS15955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RGE_RS15960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RGE_RS15965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGE_RS15990	COG0789	Transcriptional regulator
RGE_RS16005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RGE_RS16010	COG1960	acyl-CoA dehydrogenase activity
RGE_RS16015	COG1024	Enoyl-CoA hydratase
RGE_RS16025	COG3246	L-lysine catabolic process to acetate
RGE_RS16050	COG0826	peptidase U32
RGE_RS16060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RGE_RS16065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RGE_RS16075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RGE_RS16085	COG3279	Response regulator of the LytR AlgR family
RGE_RS16100	COG2815	serine threonine protein kinase
RGE_RS16100	COG0515	serine threonine protein kinase
RGE_RS16115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RGE_RS16120	COG0254	rRNA binding
RGE_RS16130	COG5002	protein histidine kinase activity
RGE_RS16145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RGE_RS16150	COG0581	inorganic phosphate transmembrane transporter activity
RGE_RS16155	COG0573	inorganic phosphate transmembrane transporter activity
RGE_RS16160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RGE_RS16165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RGE_RS16170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RGE_RS16180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGE_RS16185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RGE_RS16190	COG1534	Rna-binding protein
RGE_RS16200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RGE_RS16205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RGE_RS16210	COG0505	Belongs to the CarA family
RGE_RS16220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RGE_RS16235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RGE_RS16240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RGE_RS16265	COG0644	oxidoreductase
RGE_RS16270	COG2211	Major facilitator Superfamily
RGE_RS16275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RGE_RS16280	COG1233	COG1233 Phytoene dehydrogenase and related
RGE_RS16300	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGE_RS16305	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGE_RS16310	COG1429	ligase activity, forming nitrogen-metal bonds
RGE_RS16315	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RGE_RS16325	COG2814	Major facilitator Superfamily
RGE_RS16345	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
RGE_RS16355	COG1562	ergosterol biosynthetic process
RGE_RS16410	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGE_RS16415	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGE_RS16420	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RGE_RS16425	COG1063	alcohol dehydrogenase
RGE_RS16430	COG0500	methyltransferase
RGE_RS16435	COG0142	geranyltranstransferase activity
RGE_RS16450	COG0437	4 iron, 4 sulfur cluster binding
RGE_RS16460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGE_RS16465	COG2226	methyltransferase
RGE_RS16475	COG2867	negative regulation of translational initiation
RGE_RS16480	COG0412	Dienelactone hydrolase
RGE_RS16485	COG0248	Ppx GppA phosphatase
RGE_RS16510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RGE_RS16520	COG0210	DNA helicase
RGE_RS16530	COG0516	GMP reductase activity
RGE_RS16535	COG2199	diguanylate cyclase activity
RGE_RS16545	COG0525	valine-tRNA ligase activity
RGE_RS16560	COG0425	Belongs to the sulfur carrier protein TusA family
RGE_RS16565	COG2816	NAD+ diphosphatase activity
RGE_RS16620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RGE_RS16625	COG0835	chemotaxis
RGE_RS16630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RGE_RS16635	COG1674	ftsk spoiiie
RGE_RS16640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGE_RS16645	COG0492	ferredoxin-NADP+ reductase activity
RGE_RS16650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RGE_RS16655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RGE_RS16665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RGE_RS16665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RGE_RS16670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RGE_RS16675	COG0180	Tryptophanyl-tRNA synthetase
RGE_RS16680	COG0400	carboxylic ester hydrolase activity
RGE_RS16685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RGE_RS16710	COG0657	acetylesterase activity
RGE_RS16715	COG3012	SEC-C Motif Domain Protein
RGE_RS16730	COG4989	oxidoreductase activity
RGE_RS16745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RGE_RS16785	COG0840	transmembrane signaling receptor activity
RGE_RS16790	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS16795	COG0346	lactoylglutathione lyase activity
RGE_RS16800	COG0800	Aldolase
RGE_RS16815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RGE_RS16820	COG0259	pyridoxamine-phosphate oxidase activity
RGE_RS16840	COG2197	response regulator
RGE_RS16850	COG3264	Mechanosensitive ion channel
RGE_RS16850	COG1196	nuclear chromosome segregation
RGE_RS16855	COG0123	including yeast histone deacetylase and acetoin utilization protein
RGE_RS16860	COG0714	Associated with various cellular activities
RGE_RS16875	COG2951	lytic endotransglycosylase activity
RGE_RS16885	COG2308	Evidence 4 Homologs of previously reported genes of
RGE_RS16895	COG2308	Evidence 4 Homologs of previously reported genes of
RGE_RS16895	COG2307	Protein conserved in bacteria
RGE_RS16920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RGE_RS16950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGE_RS16965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGE_RS16970	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RGE_RS16985	COG2850	peptidyl-arginine hydroxylation
RGE_RS16990	COG1047	Peptidyl-prolyl cis-trans
RGE_RS16995	COG0756	dUTP diphosphatase activity
RGE_RS17000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RGE_RS17005	COG3318	Belongs to the UPF0149 family
RGE_RS17005	COG3012	SEC-C Motif Domain Protein
RGE_RS17010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RGE_RS17015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RGE_RS17025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGE_RS17035	COG3842	ATPase activity
RGE_RS17045	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGE_RS17050	COG1177	transmembrane transport
RGE_RS17075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RGE_RS17080	COG1968	undecaprenyl-diphosphatase activity
RGE_RS17090	COG1309	transcriptional regulator
RGE_RS17095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RGE_RS17100	COG1538	Outer membrane efflux protein
RGE_RS17115	COG0490	domain, Protein
RGE_RS17115	COG0471	metal ion transport
RGE_RS17210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RGE_RS17215	COG3781	membrane
RGE_RS17225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RGE_RS17230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RGE_RS17235	COG1047	Peptidyl-prolyl cis-trans
RGE_RS17240	COG2003	Belongs to the UPF0758 family
RGE_RS17245	COG1193	negative regulation of DNA recombination
RGE_RS17275	COG3706	GGDEF domain
RGE_RS17280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RGE_RS17285	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RGE_RS17290	COG2201	protein-glutamate methylesterase activity
RGE_RS17295	COG0730	response to heat
RGE_RS17300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGE_RS17305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RGE_RS17310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RGE_RS17315	COG0631	protein serine/threonine phosphatase activity
RGE_RS17325	COG1561	YicC-like family, N-terminal region
RGE_RS17335	COG0277	FAD linked oxidase domain protein
RGE_RS17340	COG1304	FMN binding
RGE_RS17345	COG2186	Transcriptional regulator
RGE_RS17350	COG1620	l-lactate permease
RGE_RS17355	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RGE_RS17380	COG1012	belongs to the aldehyde dehydrogenase family
RGE_RS17385	COG3284	Transcriptional regulator
RGE_RS17390	COG0194	GDP metabolic process
RGE_RS17395	COG1758	RNA polymerase activity
RGE_RS17410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RGE_RS17420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RGE_RS17430	COG3647	Membrane
RGE_RS17450	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RGE_RS17460	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RGE_RS17465	COG0298	carbon dioxide binding
RGE_RS17470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RGE_RS17475	COG1773	rubredoxin
RGE_RS17480	COG1773	rubredoxin
RGE_RS17485	COG1773	rubredoxin
RGE_RS17490	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RGE_RS17495	COG0375	protein maturation
RGE_RS17500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RGE_RS17505	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RGE_RS17510	COG0298	carbon dioxide binding
RGE_RS17515	COG0409	Hydrogenase expression formation protein
RGE_RS17520	COG0309	Hydrogenase expression formation protein (HypE)
RGE_RS17530	COG2204	response regulator
RGE_RS17545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RGE_RS17550	COG0191	fructose-bisphosphate aldolase activity
RGE_RS17555	COG0546	phosphoglycolate phosphatase activity
RGE_RS17560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RGE_RS17565	COG3954	Phosphoribulokinase
RGE_RS17570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RGE_RS17575	COG0464	growth
RGE_RS17580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RGE_RS17590	COG1850	ribulose-bisphosphate carboxylase activity
RGE_RS17595	COG0583	DNA-binding transcription factor activity
RGE_RS17615	COG0204	Acyl-transferase
RGE_RS17625	COG0300	oxidoreductase activity
RGE_RS17660	COG2217	Heavy metal translocating P-type atpase
RGE_RS17690	COG4993	Dehydrogenase
RGE_RS17700	COG0673	inositol 2-dehydrogenase activity
RGE_RS17710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RGE_RS17795	COG2205	protein histidine kinase activity
RGE_RS17795	COG0784	Response regulator, receiver
RGE_RS17820	COG0181	hydroxymethylbilane synthase activity
RGE_RS17825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RGE_RS17835	COG3275	phosphorelay sensor kinase activity
RGE_RS17840	COG0165	Argininosuccinate lyase
RGE_RS17845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RGE_RS17865	COG0717	Belongs to the dCTP deaminase family
RGE_RS17890	COG0840	transmembrane signaling receptor activity
RGE_RS17905	COG3383	formate dehydrogenase (NAD+) activity
RGE_RS17920	COG0583	DNA-binding transcription factor activity
RGE_RS17925	COG2223	nitrite transmembrane transporter activity
RGE_RS17930	COG0489	protein tyrosine kinase activity
RGE_RS17935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGE_RS17935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGE_RS17940	COG4251	negative regulation of phosphorylation
RGE_RS17955	COG0659	secondary active sulfate transmembrane transporter activity
RGE_RS17980	COG2205	protein histidine kinase activity
RGE_RS17980	COG0784	Response regulator, receiver
RGE_RS17985	COG2197	response regulator
RGE_RS17990	COG0489	protein tyrosine kinase activity
RGE_RS18030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGE_RS18050	COG0729	surface antigen
RGE_RS18080	COG3573	Dehydrogenase
RGE_RS18085	COG0028	Belongs to the TPP enzyme family
RGE_RS18105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RGE_RS18110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RGE_RS18120	COG1598	PFAM Uncharacterised protein family UPF0150
RGE_RS18185	COG0318	PFAM AMP-dependent synthetase and ligase
RGE_RS18200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RGE_RS18200	COG2111	Na H antiporter
RGE_RS18205	COG1006	Multisubunit Na H antiporter MnhC subunit
RGE_RS18210	COG0651	ATP synthesis coupled electron transport
RGE_RS18220	COG2212	antiporter activity
RGE_RS18225	COG1320	monovalent cation:proton antiporter activity
RGE_RS18230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RGE_RS18240	COG0850	regulation of cytokinetic process
RGE_RS18245	COG0840	transmembrane signaling receptor activity
RGE_RS18275	COG4251	negative regulation of phosphorylation
RGE_RS18275	COG5001	Diguanylate cyclase
RGE_RS18275	COG2203	Gaf domain
RGE_RS18275	COG3706	GGDEF domain
RGE_RS18280	COG0835	chemotaxis
RGE_RS18290	COG0643	Histidine kinase
RGE_RS18290	COG2198	Histidine kinase
RGE_RS18315	COG0405	Gamma-glutamyltransferase
RGE_RS18320	COG0840	transmembrane signaling receptor activity
RGE_RS18325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RGE_RS18330	COG1074	ATP-dependent DNA helicase activity
RGE_RS18335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RGE_RS18360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RGE_RS18370	COG3842	ATPase activity
RGE_RS18380	COG0793	Belongs to the peptidase S41A family
RGE_RS18390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RGE_RS18400	COG0010	Belongs to the arginase family
RGE_RS18410	COG1360	Flagellar Motor Protein
RGE_RS18415	COG3459	Glycosyltransferase 36 associated
RGE_RS18470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RGE_RS18485	COG1201	RNA secondary structure unwinding
RGE_RS18500	COG1653	transport
RGE_RS18520	COG2223	nitrite transmembrane transporter activity
RGE_RS18530	COG2814	Major facilitator Superfamily
RGE_RS18550	COG0583	DNA-binding transcription factor activity
RGE_RS18555	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS18560	COG5001	Diguanylate cyclase
RGE_RS18560	COG3300	MHYT domain
RGE_RS18570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RGE_RS18605	COG2986	histidine ammonia-lyase
RGE_RS18610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RGE_RS18615	COG2188	Transcriptional regulator
RGE_RS18625	COG1228	amidohydrolase
RGE_RS18635	COG0402	S-adenosylhomocysteine deaminase activity
RGE_RS18720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RGE_RS18740	COG2831	hemolysin activation secretion protein
RGE_RS18750	COG0513	Belongs to the DEAD box helicase family
RGE_RS18755	COG0513	Belongs to the DEAD box helicase family
RGE_RS18760	COG1451	nucleotide metabolic process
RGE_RS18770	COG1454	alcohol dehydrogenase
RGE_RS18775	COG0583	DNA-binding transcription factor activity
RGE_RS18780	COG0300	oxidoreductase activity
RGE_RS18800	COG1530	ribonuclease E activity
RGE_RS18805	COG0424	maF-like protein
RGE_RS18810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RGE_RS18815	COG0799	negative regulation of ribosome biogenesis
RGE_RS18820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RGE_RS18825	COG0408	coproporphyrinogen oxidase activity
RGE_RS18830	COG0151	Belongs to the GarS family
RGE_RS18835	COG0217	transcriptional regulatory protein
RGE_RS18840	COG0433	COG0433 Predicted ATPase
RGE_RS18860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RGE_RS18870	COG0545	Peptidyl-prolyl cis-trans isomerase
RGE_RS18875	COG2354	Protein conserved in bacteria
RGE_RS18890	COG1192	Involved in chromosome partitioning
RGE_RS18895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGE_RS18905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RGE_RS18930	COG0572	uridine kinase
RGE_RS18960	COG3547	Transposase (IS116 IS110 IS902 family)
RGE_RS18975	COG1132	(ABC) transporter
RGE_RS18985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RGE_RS19010	COG0741	lytic transglycosylase activity
RGE_RS19015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RGE_RS19020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RGE_RS19055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RGE_RS19055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RGE_RS19070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RGE_RS19075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RGE_RS19080	COG0436	Aminotransferase
RGE_RS19085	COG0824	Thioesterase
RGE_RS19105	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RGE_RS19110	COG2194	sulfuric ester hydrolase activity
RGE_RS19125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RGE_RS19130	COG1131	(ABC) transporter
RGE_RS19150	COG4772	TonB-dependent receptor
RGE_RS19190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RGE_RS19195	COG2197	response regulator
RGE_RS19210	COG0745	RESPONSE REGULATOR receiver
RGE_RS19225	COG0840	transmembrane signaling receptor activity
RGE_RS19230	COG0840	transmembrane signaling receptor activity
RGE_RS19235	COG0835	chemotaxis
RGE_RS19240	COG0840	transmembrane signaling receptor activity
RGE_RS19245	COG2205	protein histidine kinase activity
RGE_RS19250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RGE_RS19255	COG3384	dioxygenase
RGE_RS19310	COG2814	Major facilitator Superfamily
RGE_RS19320	COG1785	Belongs to the alkaline phosphatase family
RGE_RS19330	COG1136	(ABC) transporter
RGE_RS19340	COG1063	alcohol dehydrogenase
RGE_RS19345	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
RGE_RS19350	COG4251	negative regulation of phosphorylation
RGE_RS19405	COG0829	nickel cation binding
RGE_RS19410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGE_RS19430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGE_RS19435	COG1116	anion transmembrane transporter activity
RGE_RS19465	COG2351	hydroxyisourate hydrolase activity
RGE_RS19475	COG3479	Phenolic acid decarboxylase
RGE_RS19495	COG0318	PFAM AMP-dependent synthetase and ligase
RGE_RS19510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RGE_RS19520	COG0402	S-adenosylhomocysteine deaminase activity
RGE_RS19525	COG3845	ABC transporter
RGE_RS19530	COG4603	Belongs to the binding-protein-dependent transport system permease family
RGE_RS19545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RGE_RS19550	COG1164	Oligoendopeptidase f
RGE_RS19560	COG2198	Histidine kinase
RGE_RS19560	COG0784	Response regulator, receiver
RGE_RS19560	COG5002	protein histidine kinase activity
RGE_RS19565	COG0831	urea catabolic process
RGE_RS19570	COG0832	Belongs to the urease beta subunit family
RGE_RS19575	COG0804	urea catabolic process
RGE_RS19585	COG0189	ligase activity
RGE_RS19585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RGE_RS19590	COG0189	ligase activity
RGE_RS19590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RGE_RS19595	COG1132	(ABC) transporter
RGE_RS19610	COG0473	3-isopropylmalate dehydrogenase activity
RGE_RS19625	COG5441	Belongs to the UPF0261 family
RGE_RS19630	COG5564	TIM-barrel signal transduction protein
RGE_RS19635	COG2154	pterin-4-alpha-carbinolamine dehydratase
RGE_RS19645	COG0702	epimerase
RGE_RS19655	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
RGE_RS19670	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
RGE_RS19680	COG3284	Transcriptional regulator
RGE_RS19720	COG1029	Formylmethanofuran dehydrogenase, subunit B
RGE_RS19725	COG1229	Formylmethanofuran dehydrogenase subunit A
RGE_RS19730	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
RGE_RS19755	COG0840	transmembrane signaling receptor activity
RGE_RS19790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RGE_RS19805	COG0535	radical SAM domain protein
RGE_RS19885	COG2197	response regulator
RGE_RS19895	COG4251	negative regulation of phosphorylation
RGE_RS19900	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RGE_RS19905	COG0830	nickel cation binding
RGE_RS19910	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RGE_RS19920	COG1918	ferrous iron import across plasma membrane
RGE_RS19920	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RGE_RS19930	COG0598	Magnesium transport protein CorA
RGE_RS19940	COG2814	Major facilitator Superfamily
RGE_RS19945	COG1566	PFAM secretion protein HlyD family protein
RGE_RS19950	COG1538	Outer membrane efflux protein
RGE_RS19960	COG0688	phosphatidylethanolamine metabolic process
RGE_RS19975	COG0546	phosphoglycolate phosphatase activity
RGE_RS19985	COG1530	ribonuclease E activity
RGE_RS20000	COG0736	holo-[acyl-carrier-protein] synthase activity
RGE_RS20005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RGE_RS20010	COG1381	Involved in DNA repair and RecF pathway recombination
RGE_RS20015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RGE_RS20020	COG0571	ribonuclease III activity
RGE_RS20030	COG0681	Belongs to the peptidase S26 family
RGE_RS20035	COG0481	GTPase activity
RGE_RS20040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGE_RS20065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RGE_RS20070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RGE_RS20075	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS20080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RGE_RS20085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RGE_RS20090	COG0416	fatty acid biosynthetic process
RGE_RS20095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RGE_RS20100	COG1399	metal-binding, possibly nucleic acid-binding protein
RGE_RS20105	COG0424	maF-like protein
RGE_RS20115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RGE_RS20120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGE_RS20125	COG0513	Belongs to the DEAD box helicase family
RGE_RS20145	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RGE_RS20180	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RGE_RS20185	COG1091	dTDP-4-dehydrorhamnose reductase activity
RGE_RS20200	COG1086	Polysaccharide biosynthesis protein
RGE_RS20205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RGE_RS20210	COG4636	protein conserved in cyanobacteria
RGE_RS20215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RGE_RS20230	COG0438	transferase activity, transferring glycosyl groups
RGE_RS20255	COG0673	inositol 2-dehydrogenase activity
RGE_RS20260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RGE_RS20270	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RGE_RS20275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGE_RS20280	COG1024	Enoyl-CoA hydratase
RGE_RS20305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RGE_RS20310	COG0352	thiamine-phosphate diphosphorylase activity
RGE_RS20310	COG0351	phosphomethylpyrimidine kinase
RGE_RS20315	COG0352	thiamine-phosphate diphosphorylase activity
RGE_RS20320	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RGE_RS20330	COG0012	GTP binding
RGE_RS20355	COG1999	signal sequence binding
RGE_RS20360	COG0109	protoheme IX farnesyltransferase activity
RGE_RS20395	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RGE_RS20400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RGE_RS20410	COG2226	methyltransferase
RGE_RS20415	COG1040	competence protein
RGE_RS20420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RGE_RS20425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RGE_RS20430	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RGE_RS20435	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RGE_RS20440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RGE_RS20445	COG0588	phosphoglycerate mutase activity
RGE_RS20455	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RGE_RS20465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RGE_RS20470	COG0540	Belongs to the ATCase OTCase family
RGE_RS20475	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RGE_RS20480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RGE_RS20485	COG1678	Uncharacterized ACR, COG1678
RGE_RS20490	COG0415	Belongs to the DNA photolyase family
RGE_RS20510	COG0840	transmembrane signaling receptor activity
RGE_RS20535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RGE_RS20545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RGE_RS20550	COG3150	esterase
RGE_RS20555	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS20560	COG0557	exoribonuclease II activity
RGE_RS20570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RGE_RS20575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RGE_RS20590	COG0511	ligase activity, forming carbon-carbon bonds
RGE_RS20595	COG0439	Biotin carboxylase
RGE_RS20600	COG2264	protein methyltransferase activity
RGE_RS20610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGE_RS20650	COG4137	Cytochrome C assembly protein
RGE_RS20655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RGE_RS20675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RGE_RS20685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RGE_RS20690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RGE_RS20695	COG2890	protein-(glutamine-N5) methyltransferase activity
RGE_RS20705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RGE_RS20715	COG0741	lytic transglycosylase activity
RGE_RS20720	COG0442	prolyl-tRNA aminoacylation
RGE_RS20725	COG0494	nUDIX hydrolase
RGE_RS20730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RGE_RS20735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RGE_RS20740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RGE_RS20745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RGE_RS20750	COG0142	geranyltranstransferase activity
RGE_RS20765	COG0840	transmembrane signaling receptor activity
RGE_RS20790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RGE_RS20795	COG0237	dephospho-CoA kinase activity
RGE_RS20800	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RGE_RS20805	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RGE_RS20815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RGE_RS20820	COG0316	Belongs to the HesB IscA family
RGE_RS20835	COG5554	nitrogen fixation
RGE_RS20855	COG5554	nitrogen fixation
RGE_RS20900	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RGE_RS20910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGE_RS20930	COG2205	protein histidine kinase activity
RGE_RS20930	COG5002	protein histidine kinase activity
RGE_RS20930	COG0784	Response regulator, receiver
RGE_RS20935	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGE_RS20940	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGE_RS20955	COG5420	small protein containing a coiled-coil domain
RGE_RS20960	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
RGE_RS20980	COG1104	cysteine desulfurase activity
RGE_RS20985	COG0822	iron-sulfur transferase activity
RGE_RS20990	COG0316	Belongs to the HesB IscA family
RGE_RS20995	COG0316	Belongs to the HesB IscA family
RGE_RS21000	COG0443	Heat shock 70 kDa protein
RGE_RS21005	COG0633	Ferredoxin
RGE_RS21025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RGE_RS21050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RGE_RS21055	COG0459	protein refolding
RGE_RS21065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RGE_RS21075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RGE_RS21080	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RGE_RS21085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RGE_RS21105	COG0318	PFAM AMP-dependent synthetase and ligase
RGE_RS21120	COG5002	protein histidine kinase activity
RGE_RS21120	COG2176	DNA-directed DNA polymerase activity
RGE_RS21125	COG0745	RESPONSE REGULATOR receiver
RGE_RS21175	COG1024	Enoyl-CoA hydratase
RGE_RS21185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RGE_RS21195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RGE_RS21200	COG0569	domain protein
RGE_RS21220	COG0183	Belongs to the thiolase family
RGE_RS21225	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RGE_RS21230	COG0288	reversible hydration of carbon dioxide
RGE_RS21235	COG1960	acyl-CoA dehydrogenase activity
RGE_RS21250	COG2186	Transcriptional regulator
RGE_RS21260	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGE_RS21270	COG3842	ATPase activity
RGE_RS21285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RGE_RS21290	COG0751	glycine-tRNA ligase activity
RGE_RS21295	COG0752	glycyl-tRNA synthetase alpha subunit
RGE_RS21300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RGE_RS21305	COG4535	Mg2 and Co2 transporter CorC
RGE_RS21310	COG0523	cobalamin synthesis protein
RGE_RS21325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RGE_RS21330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RGE_RS21335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RGE_RS21340	COG1703	isobutyryl-CoA mutase activity
RGE_RS21340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RGE_RS21340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RGE_RS21360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RGE_RS21370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS21375	COG1136	(ABC) transporter
RGE_RS21375	COG0577	efflux transmembrane transporter activity
RGE_RS21380	COG0577	efflux transmembrane transporter activity
RGE_RS21380	COG1136	(ABC) transporter
RGE_RS21395	COG0861	Integral membrane protein TerC family
RGE_RS21410	COG3128	pkhd-type hydroxylase
RGE_RS21435	COG1522	sequence-specific DNA binding
RGE_RS21440	COG3186	Phenylalanine-4-hydroxylase
RGE_RS21485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RGE_RS21490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RGE_RS21500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RGE_RS21510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RGE_RS21515	COG0321	lipoyl(octanoyl) transferase activity
RGE_RS21520	COG2921	Belongs to the UPF0250 family
RGE_RS21530	COG1686	Belongs to the peptidase S11 family
RGE_RS21535	COG2945	thiolester hydrolase activity
RGE_RS21540	COG3411	Ferredoxin
RGE_RS21550	COG1981	membrane
RGE_RS21560	COG0598	Magnesium transport protein CorA
RGE_RS21565	COG0697	spore germination
RGE_RS21570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RGE_RS21575	COG1702	phosphate starvation-inducible protein PhoH
RGE_RS21580	COG4585	Histidine kinase
RGE_RS21585	COG2197	response regulator
RGE_RS21590	COG0632	four-way junction helicase activity
RGE_RS21600	COG2255	four-way junction helicase activity
RGE_RS21650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RGE_RS21675	COG2974	May be involved in recombination
RGE_RS21680	COG1492	cobalamin metabolic process
RGE_RS21685	COG1492	cobalamin metabolic process
RGE_RS21700	COG3610	response to peptide
RGE_RS21705	COG2966	Psort location CytoplasmicMembrane, score
RGE_RS21715	COG0840	transmembrane signaling receptor activity
RGE_RS21760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RGE_RS21765	COG4206	TonB-dependent receptor
RGE_RS21780	COG1120	ATPase activity
RGE_RS21795	COG2204	response regulator
RGE_RS21800	COG5000	phosphorelay sensor kinase activity
RGE_RS21810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RGE_RS21830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RGE_RS21835	COG1522	sequence-specific DNA binding
RGE_RS21845	COG1872	DUF167
RGE_RS21850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RGE_RS21850	COG0551	DNA topoisomerase type I activity
RGE_RS21860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RGE_RS21860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RGE_RS21870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RGE_RS21875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RGE_RS21880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RGE_RS21885	COG0667	Aldo Keto reductase
RGE_RS21895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RGE_RS21905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RGE_RS21915	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RGE_RS21920	COG0463	Glycosyl transferase, family 2
RGE_RS21950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RGE_RS21995	COG0745	RESPONSE REGULATOR receiver
RGE_RS22005	COG1505	serine-type exopeptidase activity
RGE_RS22010	COG0745	RESPONSE REGULATOR receiver
RGE_RS22015	COG2201	protein-glutamate methylesterase activity
RGE_RS22020	COG3437	response regulator, receiver
RGE_RS22020	COG0784	Response regulator, receiver
RGE_RS22025	COG2205	protein histidine kinase activity
RGE_RS22030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RGE_RS22040	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RGE_RS22045	COG0735	belongs to the Fur family
RGE_RS22050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RGE_RS22055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RGE_RS22070	COG0495	leucyl-tRNA aminoacylation
RGE_RS22090	COG1058	Belongs to the CinA family
RGE_RS22090	COG1546	Belongs to the CinA family
RGE_RS22105	COG4566	intracellular signal transduction
RGE_RS22115	COG0281	malic enzyme
RGE_RS22115	COG0280	phosphate acetyltransferase
RGE_RS22130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RGE_RS22135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RGE_RS22140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RGE_RS22160	COG1024	Enoyl-CoA hydratase
RGE_RS22165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RGE_RS22170	COG2813	Specifically methylates the guanine in position
RGE_RS22170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RGE_RS22175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RGE_RS22185	COG0531	amino acid
RGE_RS22190	COG4303	Ethanolamine ammonia lyase large subunit
RGE_RS22195	COG4302	ethanolamine ammonia-lyase activity
RGE_RS22200	COG0625	glutathione transferase activity
RGE_RS22205	COG0402	S-adenosylhomocysteine deaminase activity
RGE_RS22210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RGE_RS22225	COG4771	TonB-dependent receptor
RGE_RS22230	COG1744	ABC transporter substrate-binding protein PnrA-like
RGE_RS22245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RGE_RS22250	COG1744	ABC transporter substrate-binding protein PnrA-like
RGE_RS22255	COG3845	ABC transporter
RGE_RS22260	COG4603	Belongs to the binding-protein-dependent transport system permease family
RGE_RS22265	COG1079	Belongs to the binding-protein-dependent transport system permease family
RGE_RS22270	COG0295	cytidine deaminase activity
RGE_RS22315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RGE_RS22320	COG4085	toxin activity
RGE_RS22320	COG0737	Belongs to the 5'-nucleotidase family
RGE_RS22320	COG1525	nuclease
RGE_RS22325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RGE_RS22330	COG0135	phosphoribosylanthranilate isomerase activity
RGE_RS22335	COG1079	Belongs to the binding-protein-dependent transport system permease family
RGE_RS22340	COG4603	Belongs to the binding-protein-dependent transport system permease family
RGE_RS22345	COG3845	ABC transporter
RGE_RS22360	COG1744	ABC transporter substrate-binding protein PnrA-like
RGE_RS22370	COG1719	4-vinyl reductase, 4VR
RGE_RS22380	COG0284	orotidine-5'-phosphate decarboxylase activity
RGE_RS22395	COG0121	glutamine amidotransferase
RGE_RS22400	COG0644	oxidoreductase
RGE_RS22410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RGE_RS22430	COG1191	sigma factor activity
RGE_RS22435	COG2815	serine threonine protein kinase
RGE_RS22435	COG0515	serine threonine protein kinase
RGE_RS22440	COG0018	arginyl-trna synthetase
RGE_RS22455	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RGE_RS22460	COG1137	ATPase activity
RGE_RS22465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RGE_RS22480	COG0154	amidase activity
RGE_RS22485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RGE_RS22495	COG0318	PFAM AMP-dependent synthetase and ligase
RGE_RS22520	COG0840	transmembrane signaling receptor activity
RGE_RS22525	COG0583	DNA-binding transcription factor activity
RGE_RS22540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RGE_RS22545	COG4208	sulfate ABC transporter
RGE_RS22550	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RGE_RS22555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RGE_RS22560	COG2267	carboxylic ester hydrolase activity
RGE_RS22565	COG0406	alpha-ribazole phosphatase activity
RGE_RS22580	COG1937	Protein conserved in bacteria
RGE_RS22615	COG0514	ATP-dependent DNA helicase (RecQ)
RGE_RS22625	COG5002	protein histidine kinase activity
RGE_RS22625	COG2205	protein histidine kinase activity
RGE_RS22625	COG0784	Response regulator, receiver
RGE_RS22645	COG1950	PFAM Membrane protein of
RGE_RS22650	COG4783	chaperone-mediated protein folding
RGE_RS22655	COG0315	cyclic pyranopterin monophosphate synthase activity
RGE_RS22660	COG3307	-O-antigen
RGE_RS22665	COG3307	-O-antigen
RGE_RS22670	COG4969	Belongs to the N-Me-Phe pilin family
RGE_RS22680	COG1716	ATPase activity
RGE_RS22685	COG0631	protein serine/threonine phosphatase activity
RGE_RS22700	COG0861	Integral membrane protein TerC family
RGE_RS22705	COG0861	Integral membrane protein TerC family
RGE_RS22715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RGE_RS22720	COG0045	succinate-CoA ligase (ADP-forming) activity
RGE_RS22730	COG2137	regulation of response to DNA damage stimulus
RGE_RS22735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RGE_RS22745	COG0642	Histidine kinase
RGE_RS22750	COG0772	Belongs to the SEDS family
RGE_RS22755	COG0768	penicillin binding
RGE_RS22770	COG1077	Cell shape determining protein MreB Mrl
RGE_RS22775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RGE_RS22780	COG0154	amidase activity
RGE_RS22785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RGE_RS22795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RGE_RS22815	COG2223	nitrite transmembrane transporter activity
RGE_RS22820	COG3118	belongs to the thioredoxin family
RGE_RS22840	COG0601	transmembrane transport
RGE_RS22860	COG0482	sulfurtransferase activity
RGE_RS22865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RGE_RS22870	COG0577	efflux transmembrane transporter activity
RGE_RS22870	COG1136	(ABC) transporter
RGE_RS22875	COG0577	efflux transmembrane transporter activity
RGE_RS22875	COG1136	(ABC) transporter
RGE_RS22880	COG1136	(ABC) transporter
RGE_RS22880	COG0577	efflux transmembrane transporter activity
RGE_RS22885	COG1022	Amp-dependent synthetase and ligase
RGE_RS22900	COG2095	MarC family integral membrane protein
RGE_RS22910	COG4221	oxidoreductase activity
RGE_RS22920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RGE_RS22935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RGE_RS22940	COG1770	oligopeptidase
RGE_RS22945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RGE_RS22950	COG0706	membrane insertase activity
RGE_RS22955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RGE_RS22965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RGE_RS23005	COG5001	Diguanylate cyclase
RGE_RS23005	COG4251	negative regulation of phosphorylation
RGE_RS23005	COG3706	GGDEF domain
RGE_RS23005	COG2203	Gaf domain
RGE_RS23030	COG3621	Patatin-like phospholipase
RGE_RS23110	COG1216	Glycosyl transferase, family 2
RGE_RS23125	COG4251	negative regulation of phosphorylation
RGE_RS23140	COG2885	chlorophyll binding
RGE_RS23170	COG3437	response regulator, receiver
RGE_RS23170	COG0784	Response regulator, receiver
RGE_RS23190	COG5002	protein histidine kinase activity
RGE_RS23190	COG0784	Response regulator, receiver
RGE_RS23190	COG2205	protein histidine kinase activity
RGE_RS23200	COG2205	protein histidine kinase activity
RGE_RS23205	COG0745	RESPONSE REGULATOR receiver
RGE_RS23220	COG0784	Response regulator, receiver
RGE_RS23220	COG4191	Histidine kinase
RGE_RS23270	COG0582	viral genome integration into host DNA
RGE_RS23285	COG5002	protein histidine kinase activity
RGE_RS23285	COG2198	Histidine kinase
RGE_RS23285	COG0784	Response regulator, receiver
RGE_RS23290	COG3706	GGDEF domain
RGE_RS23330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGE_RS23360	COG0739	heme binding
RGE_RS23360	COG0741	lytic transglycosylase activity
RGE_RS23360	COG1196	nuclear chromosome segregation
RGE_RS23370	COG3025	triphosphatase activity
RGE_RS23395	COG0778	Nitroreductase
RGE_RS23415	COG1028	Short-chain dehydrogenase reductase Sdr
RGE_RS23435	COG0724	RNA recognition motif