locus-tag	class	description
RRADSPS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RRADSPS_RS00010	COG0592	DNA-directed DNA polymerase activity
RRADSPS_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RRADSPS_RS00025	COG0187	DNA topoisomerase II activity
RRADSPS_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RRADSPS_RS00065	COG1053	succinate dehydrogenase
RRADSPS_RS00095	COG1714	RDD family
RRADSPS_RS00100	COG4221	oxidoreductase activity
RRADSPS_RS00110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RRADSPS_RS00125	COG0515	serine threonine protein kinase
RRADSPS_RS00125	COG2815	serine threonine protein kinase
RRADSPS_RS00130	COG0768	penicillin binding
RRADSPS_RS00175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RRADSPS_RS00195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RRADSPS_RS00200	COG0511	ligase activity, forming carbon-carbon bonds
RRADSPS_RS00205	COG0439	Biotin carboxylase
RRADSPS_RS00235	COG4176	ABC-type proline glycine betaine transport system permease component
RRADSPS_RS00250	COG2308	Evidence 4 Homologs of previously reported genes of
RRADSPS_RS00270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RRADSPS_RS00285	COG0629	single-stranded DNA binding
RRADSPS_RS00295	COG4297	protein containing double-stranded beta helix domain
RRADSPS_RS00300	COG3959	Transketolase, thiamine diphosphate binding domain
RRADSPS_RS00310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RRADSPS_RS00315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RRADSPS_RS00320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RRADSPS_RS00330	COG0363	glucosamine-6-phosphate deaminase activity
RRADSPS_RS00340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RRADSPS_RS00350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RRADSPS_RS00360	COG1953	Uracil, thiamine, allantoin
RRADSPS_RS00390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RRADSPS_RS00390	COG1796	DNA polymerase
RRADSPS_RS00395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RRADSPS_RS00410	COG0625	glutathione transferase activity
RRADSPS_RS00415	COG1024	Enoyl-CoA hydratase
RRADSPS_RS00430	COG0730	response to heat
RRADSPS_RS00450	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RRADSPS_RS00465	COG1104	cysteine desulfurase activity
RRADSPS_RS00470	COG4974	Belongs to the 'phage' integrase family
RRADSPS_RS00515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RRADSPS_RS00520	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RRADSPS_RS00555	COG1079	Belongs to the binding-protein-dependent transport system permease family
RRADSPS_RS00560	COG4603	Belongs to the binding-protein-dependent transport system permease family
RRADSPS_RS00565	COG3845	ABC transporter
RRADSPS_RS00570	COG1744	ABC transporter substrate-binding protein PnrA-like
RRADSPS_RS00585	COG1316	TRANSCRIPTIONal
RRADSPS_RS00600	COG0471	metal ion transport
RRADSPS_RS00605	COG0471	metal ion transport
RRADSPS_RS00625	COG1704	LemA family
RRADSPS_RS00630	COG0501	Belongs to the peptidase M48B family
RRADSPS_RS00660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RRADSPS_RS00695	COG0180	Tryptophanyl-tRNA synthetase
RRADSPS_RS00700	COG1414	Transcriptional regulator
RRADSPS_RS00705	COG4106	trans-aconitate 2-methyltransferase activity
RRADSPS_RS00710	COG2226	methyltransferase
RRADSPS_RS00715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RRADSPS_RS00720	COG0066	3-isopropylmalate dehydratase activity
RRADSPS_RS00730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RRADSPS_RS00755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RRADSPS_RS00760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RRADSPS_RS00775	COG0688	phosphatidylethanolamine metabolic process
RRADSPS_RS00805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RRADSPS_RS00810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RRADSPS_RS00845	COG0542	response to heat
RRADSPS_RS00865	COG0625	glutathione transferase activity
RRADSPS_RS00905	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
RRADSPS_RS00920	COG1940	carbohydrate kinase activity
RRADSPS_RS00945	COG1505	serine-type exopeptidase activity
RRADSPS_RS00950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RRADSPS_RS00965	COG0366	Alpha amylase catalytic
RRADSPS_RS00970	COG0366	Alpha amylase catalytic
RRADSPS_RS00975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RRADSPS_RS00985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RRADSPS_RS01000	COG0366	Alpha amylase catalytic
RRADSPS_RS01005	COG2814	Major facilitator Superfamily
RRADSPS_RS01010	COG0702	epimerase
RRADSPS_RS01020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RRADSPS_RS01070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RRADSPS_RS01085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RRADSPS_RS01095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RRADSPS_RS01100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RRADSPS_RS01115	COG0028	Belongs to the TPP enzyme family
RRADSPS_RS01135	COG0083	homoserine kinase activity
RRADSPS_RS01140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RRADSPS_RS01180	COG1091	dTDP-4-dehydrorhamnose reductase activity
RRADSPS_RS01190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RRADSPS_RS01205	COG4656	Part of a membrane complex involved in electron transport
RRADSPS_RS01215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RRADSPS_RS01220	COG1597	lipid kinase activity
RRADSPS_RS01230	COG1691	(AIR) carboxylase
RRADSPS_RS01235	COG0861	Integral membrane protein TerC family
RRADSPS_RS01245	COG5002	protein histidine kinase activity
RRADSPS_RS01245	COG3850	Histidine kinase
RRADSPS_RS01250	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS01255	COG3442	glutamine amidotransferase
RRADSPS_RS01260	COG0303	'Molybdopterin
RRADSPS_RS01275	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS01280	COG5002	protein histidine kinase activity
RRADSPS_RS01285	COG1994	Peptidase M50
RRADSPS_RS01295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RRADSPS_RS01310	COG0330	HflC and HflK could
RRADSPS_RS01320	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RRADSPS_RS01325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RRADSPS_RS01325	COG0561	phosphatase activity
RRADSPS_RS01370	COG1595	DNA-templated transcription, initiation
RRADSPS_RS01390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RRADSPS_RS01395	COG2252	PERMEase
RRADSPS_RS01445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RRADSPS_RS01455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RRADSPS_RS01465	COG1181	Belongs to the D-alanine--D-alanine ligase family
RRADSPS_RS01480	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
RRADSPS_RS01495	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RRADSPS_RS01500	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RRADSPS_RS01520	COG0248	Ppx GppA phosphatase
RRADSPS_RS01525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RRADSPS_RS01555	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS01560	COG0640	Transcriptional regulator
RRADSPS_RS01575	COG0733	neurotransmitter:sodium symporter activity
RRADSPS_RS01580	COG1802	Transcriptional regulator
RRADSPS_RS01585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RRADSPS_RS01590	COG0506	proline dehydrogenase activity
RRADSPS_RS01595	COG1012	belongs to the aldehyde dehydrogenase family
RRADSPS_RS01605	COG1072	(Pantothenic acid kinase))
RRADSPS_RS01610	COG0446	pyridine nucleotide-disulphide oxidoreductase
RRADSPS_RS01630	COG2202	Pas domain
RRADSPS_RS01630	COG1366	Belongs to the anti-sigma-factor antagonist family
RRADSPS_RS01635	COG2770	Histidine kinase
RRADSPS_RS01635	COG2208	phosphoserine phosphatase activity
RRADSPS_RS01675	COG1002	Type II restriction enzyme, methylase subunits
RRADSPS_RS01680	COG0589	response to stress
RRADSPS_RS01685	COG0531	amino acid
RRADSPS_RS01695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RRADSPS_RS01715	COG3835	regulator
RRADSPS_RS01725	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RRADSPS_RS01745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RRADSPS_RS01760	COG3711	transcriptional antiterminator
RRADSPS_RS01765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RRADSPS_RS01770	COG0246	Mannitol dehydrogenase
RRADSPS_RS01810	COG0604	alcohol dehydrogenase
RRADSPS_RS01835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RRADSPS_RS01860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RRADSPS_RS01875	COG0586	Pfam SNARE associated Golgi protein
RRADSPS_RS01890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RRADSPS_RS01895	COG0756	dUTP diphosphatase activity
RRADSPS_RS01900	COG0438	transferase activity, transferring glycosyl groups
RRADSPS_RS01920	COG1546	Belongs to the CinA family
RRADSPS_RS01920	COG1058	Belongs to the CinA family
RRADSPS_RS01935	COG5001	Diguanylate cyclase
RRADSPS_RS01940	COG0314	molybdopterin synthase activity
RRADSPS_RS01965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RRADSPS_RS01970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RRADSPS_RS01985	COG0071	Belongs to the small heat shock protein (HSP20) family
RRADSPS_RS01990	COG0542	response to heat
RRADSPS_RS02000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RRADSPS_RS02005	COG2070	2-Nitropropane dioxygenase
RRADSPS_RS02010	COG0321	lipoyl(octanoyl) transferase activity
RRADSPS_RS02015	COG2261	transglycosylase associated protein
RRADSPS_RS02040	COG1297	OPT oligopeptide transporter protein
RRADSPS_RS02045	COG3588	fructose-bisphosphate aldolase
RRADSPS_RS02050	COG1331	Highly conserved protein containing a thioredoxin domain
RRADSPS_RS02060	COG0626	cystathionine gamma-synthase activity
RRADSPS_RS02070	COG0567	Dehydrogenase, E1 component
RRADSPS_RS02075	COG0508	dehydrogenase complex catalyzes the overall conversion of
RRADSPS_RS02080	COG1703	isobutyryl-CoA mutase activity
RRADSPS_RS02105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RRADSPS_RS02110	COG0183	Belongs to the thiolase family
RRADSPS_RS02115	COG2902	Dehydrogenase
RRADSPS_RS02120	COG1960	acyl-CoA dehydrogenase activity
RRADSPS_RS02130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RRADSPS_RS02135	COG0022	dehydrogenase e1 component
RRADSPS_RS02140	COG0508	dehydrogenase complex catalyzes the overall conversion of
RRADSPS_RS02190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RRADSPS_RS02195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RRADSPS_RS02205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RRADSPS_RS02220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RRADSPS_RS02250	COG4770	biotin carboxylase activity
RRADSPS_RS02285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RRADSPS_RS02290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RRADSPS_RS02300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RRADSPS_RS02305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RRADSPS_RS02310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RRADSPS_RS02315	COG1205	dead DEAH box helicase
RRADSPS_RS02315	COG1111	helicase
RRADSPS_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS02340	COG0247	lactate metabolic process
RRADSPS_RS02345	COG1139	Iron-sulfur cluster binding protein
RRADSPS_RS02350	COG1556	Lactate utilization protein
RRADSPS_RS02355	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RRADSPS_RS02365	COG1181	Belongs to the D-alanine--D-alanine ligase family
RRADSPS_RS02370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RRADSPS_RS02375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RRADSPS_RS02380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RRADSPS_RS02385	COG0022	dehydrogenase e1 component
RRADSPS_RS02390	COG0508	dehydrogenase complex catalyzes the overall conversion of
RRADSPS_RS02395	COG2837	iron assimilation
RRADSPS_RS02400	COG2822	iron ion transport
RRADSPS_RS02405	COG0672	)-iron permease
RRADSPS_RS02440	COG0463	Glycosyl transferase, family 2
RRADSPS_RS02450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RRADSPS_RS02460	COG0706	membrane insertase activity
RRADSPS_RS02475	COG1215	transferase activity, transferring glycosyl groups
RRADSPS_RS02480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RRADSPS_RS02485	COG0546	phosphoglycolate phosphatase activity
RRADSPS_RS02495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RRADSPS_RS02510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RRADSPS_RS02515	COG1937	Protein conserved in bacteria
RRADSPS_RS02530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RRADSPS_RS02540	COG0284	orotidine-5'-phosphate decarboxylase activity
RRADSPS_RS02565	COG3118	belongs to the thioredoxin family
RRADSPS_RS02570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RRADSPS_RS02575	COG0860	N-Acetylmuramoyl-L-alanine amidase
RRADSPS_RS02590	COG0488	(ABC) transporter
RRADSPS_RS02600	COG1490	D-aminoacyl-tRNA deacylase activity
RRADSPS_RS02625	COG0728	peptidoglycan biosynthetic process
RRADSPS_RS02635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RRADSPS_RS02640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RRADSPS_RS02650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RRADSPS_RS02655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RRADSPS_RS02665	COG0561	phosphatase activity
RRADSPS_RS02670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RRADSPS_RS02710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RRADSPS_RS02715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RRADSPS_RS02720	COG1515	deoxyribonuclease V activity
RRADSPS_RS02830	COG2223	nitrite transmembrane transporter activity
RRADSPS_RS02840	COG1140	nitrate reductase beta subunit
RRADSPS_RS02845	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RRADSPS_RS02850	COG2181	nitrate reductase activity
RRADSPS_RS02855	COG3199	ATP-NAD kinase
RRADSPS_RS02865	COG0022	dehydrogenase e1 component
RRADSPS_RS02870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RRADSPS_RS02895	COG2022	thiamine diphosphate biosynthetic process
RRADSPS_RS02900	COG0352	thiamine-phosphate diphosphorylase activity
RRADSPS_RS02915	COG1063	alcohol dehydrogenase
RRADSPS_RS02930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RRADSPS_RS02945	COG1733	regulation of RNA biosynthetic process
RRADSPS_RS02950	COG2259	Doxx family
RRADSPS_RS02955	COG2514	catechol 2,3-dioxygenase activity
RRADSPS_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS02985	COG0183	Belongs to the thiolase family
RRADSPS_RS03030	COG0730	response to heat
RRADSPS_RS03050	COG0477	Major facilitator Superfamily
RRADSPS_RS03055	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS03060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RRADSPS_RS03075	COG1024	Enoyl-CoA hydratase
RRADSPS_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS03115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RRADSPS_RS03125	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RRADSPS_RS03135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RRADSPS_RS03140	COG1414	Transcriptional regulator
RRADSPS_RS03145	COG1012	belongs to the aldehyde dehydrogenase family
RRADSPS_RS03150	COG1454	alcohol dehydrogenase
RRADSPS_RS03155	COG3119	arylsulfatase activity
RRADSPS_RS03160	COG2199	diguanylate cyclase activity
RRADSPS_RS03160	COG2203	Gaf domain
RRADSPS_RS03160	COG2200	EAL domain
RRADSPS_RS03170	COG0318	PFAM AMP-dependent synthetase and ligase
RRADSPS_RS03175	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS03190	COG0328	RNA-DNA hybrid ribonuclease activity
RRADSPS_RS03215	COG0423	glycine-tRNA ligase activity
RRADSPS_RS03260	COG0443	Heat shock 70 kDa protein
RRADSPS_RS03265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RRADSPS_RS03270	COG0484	heat shock protein binding
RRADSPS_RS03275	COG0789	Transcriptional regulator
RRADSPS_RS03315	COG1254	Belongs to the acylphosphatase family
RRADSPS_RS03320	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RRADSPS_RS03345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RRADSPS_RS03350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RRADSPS_RS03355	COG1597	lipid kinase activity
RRADSPS_RS03365	COG0736	holo-[acyl-carrier-protein] synthase activity
RRADSPS_RS03370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RRADSPS_RS03370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RRADSPS_RS03380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RRADSPS_RS03405	COG0802	atpase or kinase
RRADSPS_RS03410	COG1214	PFAM Peptidase M22, glycoprotease
RRADSPS_RS03410	COG0456	acetyltransferase
RRADSPS_RS03415	COG0456	acetyltransferase
RRADSPS_RS03445	COG0459	protein refolding
RRADSPS_RS03450	COG0516	GMP reductase activity
RRADSPS_RS03455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RRADSPS_RS03455	COG0519	Catalyzes the synthesis of GMP from XMP
RRADSPS_RS03465	COG0589	response to stress
RRADSPS_RS03480	COG0573	inorganic phosphate transmembrane transporter activity
RRADSPS_RS03485	COG0581	inorganic phosphate transmembrane transporter activity
RRADSPS_RS03490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RRADSPS_RS03515	COG0318	PFAM AMP-dependent synthetase and ligase
RRADSPS_RS03540	COG0210	DNA helicase
RRADSPS_RS03545	COG1227	inorganic diphosphatase activity
RRADSPS_RS03545	COG0517	IMP dehydrogenase activity
RRADSPS_RS03550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RRADSPS_RS03555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RRADSPS_RS03560	COG0154	amidase activity
RRADSPS_RS03565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RRADSPS_RS03570	COG0129	dihydroxy-acid dehydratase activity
RRADSPS_RS03575	COG5001	Diguanylate cyclase
RRADSPS_RS03580	COG3217	Mosc domain protein beta barrel domain protein
RRADSPS_RS03580	COG0633	Ferredoxin
RRADSPS_RS03585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RRADSPS_RS03590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RRADSPS_RS03615	COG0646	methionine synthase
RRADSPS_RS03615	COG1410	methionine synthase
RRADSPS_RS03620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RRADSPS_RS03620	COG0646	methionine synthase
RRADSPS_RS03635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RRADSPS_RS03640	COG1136	(ABC) transporter
RRADSPS_RS03640	COG0577	efflux transmembrane transporter activity
RRADSPS_RS03645	COG1136	(ABC) transporter
RRADSPS_RS03650	COG0360	Binds together with S18 to 16S ribosomal RNA
RRADSPS_RS03655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RRADSPS_RS03660	COG0359	binds to the 23S rRNA
RRADSPS_RS03665	COG0305	Participates in initiation and elongation during chromosome replication
RRADSPS_RS03675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RRADSPS_RS03700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RRADSPS_RS03715	COG2738	Putative neutral zinc metallopeptidase
RRADSPS_RS03725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RRADSPS_RS03735	COG0297	glycogen (starch) synthase activity
RRADSPS_RS03740	COG0463	Glycosyl transferase, family 2
RRADSPS_RS03760	COG1595	DNA-templated transcription, initiation
RRADSPS_RS03800	COG4166	transmembrane transport
RRADSPS_RS03805	COG0601	transmembrane transport
RRADSPS_RS03810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RRADSPS_RS03815	COG0444	Belongs to the ABC transporter superfamily
RRADSPS_RS03820	COG4608	Belongs to the ABC transporter superfamily
RRADSPS_RS03830	COG2308	Evidence 4 Homologs of previously reported genes of
RRADSPS_RS03835	COG4533	DNA binding
RRADSPS_RS03840	COG0793	Belongs to the peptidase S41A family
RRADSPS_RS03840	COG3409	Peptidoglycan-binding domain 1 protein
RRADSPS_RS03845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RRADSPS_RS03860	COG3794	PFAM blue (type 1) copper domain protein
RRADSPS_RS03865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RRADSPS_RS03865	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RRADSPS_RS03870	COG1940	carbohydrate kinase activity
RRADSPS_RS03875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RRADSPS_RS03880	COG0084	hydrolase, TatD family'
RRADSPS_RS03885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RRADSPS_RS03890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RRADSPS_RS03900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RRADSPS_RS03905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RRADSPS_RS03910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RRADSPS_RS03915	COG0193	aminoacyl-tRNA hydrolase activity
RRADSPS_RS03920	COG2186	Transcriptional regulator
RRADSPS_RS03940	COG0697	spore germination
RRADSPS_RS03965	COG0148	phosphopyruvate hydratase activity
RRADSPS_RS04025	COG1492	cobalamin metabolic process
RRADSPS_RS04050	COG1797	cobyrinic acid a,c-diamide synthase activity
RRADSPS_RS04065	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
RRADSPS_RS04095	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RRADSPS_RS04100	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RRADSPS_RS04105	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RRADSPS_RS04110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RRADSPS_RS04120	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
RRADSPS_RS04155	COG0517	IMP dehydrogenase activity
RRADSPS_RS04190	COG1609	Transcriptional regulator
RRADSPS_RS04195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RRADSPS_RS04225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RRADSPS_RS04230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RRADSPS_RS04270	COG1191	sigma factor activity
RRADSPS_RS04285	COG1459	type II secretion system
RRADSPS_RS04295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RRADSPS_RS04305	COG0095	Lipoate-protein ligase
RRADSPS_RS04310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RRADSPS_RS04320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RRADSPS_RS04325	COG0778	Nitroreductase
RRADSPS_RS04325	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
RRADSPS_RS04335	COG0175	sulfate reduction
RRADSPS_RS04340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RRADSPS_RS04355	COG2046	Belongs to the sulfate adenylyltransferase family
RRADSPS_RS04360	COG0529	Catalyzes the synthesis of activated sulfate
RRADSPS_RS04390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RRADSPS_RS04395	COG2897	thiosulfate sulfurtransferase activity
RRADSPS_RS04405	COG0165	Argininosuccinate lyase
RRADSPS_RS04410	COG1115	amino acid carrier protein
RRADSPS_RS04425	COG2066	Belongs to the glutaminase family
RRADSPS_RS04450	COG0517	IMP dehydrogenase activity
RRADSPS_RS04450	COG1125	glycine betaine transport
RRADSPS_RS04480	COG1653	transport
RRADSPS_RS04485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RRADSPS_RS04500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RRADSPS_RS04505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RRADSPS_RS04510	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RRADSPS_RS04515	COG0047	phosphoribosylformylglycinamidine synthase activity
RRADSPS_RS04520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RRADSPS_RS04530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RRADSPS_RS04540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RRADSPS_RS04545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RRADSPS_RS04550	COG0138	bifunctional purine biosynthesis protein purh
RRADSPS_RS04560	COG0439	Biotin carboxylase
RRADSPS_RS04570	COG1984	allophanate hydrolase subunit 2
RRADSPS_RS04575	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RRADSPS_RS04590	COG4572	Cation transport regulator
RRADSPS_RS04600	COG0297	glycogen (starch) synthase activity
RRADSPS_RS04615	COG1216	Glycosyl transferase, family 2
RRADSPS_RS04635	COG0463	Glycosyl transferase, family 2
RRADSPS_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS04680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RRADSPS_RS04695	COG4191	Histidine kinase
RRADSPS_RS04710	COG1755	Isoprenylcysteine carboxyl methyltransferase
RRADSPS_RS04715	COG3424	synthase
RRADSPS_RS04745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RRADSPS_RS04765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RRADSPS_RS04775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RRADSPS_RS04780	COG1234	tRNA 3'-trailer cleavage
RRADSPS_RS04800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RRADSPS_RS04805	COG0697	spore germination
RRADSPS_RS04815	COG0123	including yeast histone deacetylase and acetoin utilization protein
RRADSPS_RS04820	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RRADSPS_RS04840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RRADSPS_RS04845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RRADSPS_RS04845	COG2111	Na H antiporter
RRADSPS_RS04855	COG1006	Multisubunit Na H antiporter MnhC subunit
RRADSPS_RS04860	COG0651	ATP synthesis coupled electron transport
RRADSPS_RS04870	COG2212	antiporter activity
RRADSPS_RS04875	COG1320	monovalent cation:proton antiporter activity
RRADSPS_RS04880	COG0651	ATP synthesis coupled electron transport
RRADSPS_RS04885	COG0651	ATP synthesis coupled electron transport
RRADSPS_RS04890	COG0651	ATP synthesis coupled electron transport
RRADSPS_RS04895	COG1006	Multisubunit Na H antiporter MnhC subunit
RRADSPS_RS04905	COG1320	monovalent cation:proton antiporter activity
RRADSPS_RS04910	COG2212	antiporter activity
RRADSPS_RS04935	COG0598	Magnesium transport protein CorA
RRADSPS_RS04965	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS05000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RRADSPS_RS05015	COG1619	proteins homologs of microcin C7 resistance protein MccF
RRADSPS_RS05025	COG0400	carboxylic ester hydrolase activity
RRADSPS_RS05030	COG0346	lactoylglutathione lyase activity
RRADSPS_RS05045	COG3293	Transposase
RRADSPS_RS05070	COG2311	Membrane
RRADSPS_RS05080	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RRADSPS_RS05090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RRADSPS_RS05090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RRADSPS_RS05100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RRADSPS_RS05105	COG2376	Dihydroxyacetone kinase
RRADSPS_RS05120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RRADSPS_RS05120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RRADSPS_RS05120	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RRADSPS_RS05165	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RRADSPS_RS05180	COG1606	tRNA processing
RRADSPS_RS05185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RRADSPS_RS05190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RRADSPS_RS05205	COG0385	Bile acid
RRADSPS_RS05210	COG0442	prolyl-tRNA aminoacylation
RRADSPS_RS05215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RRADSPS_RS05225	COG0460	homoserine dehydrogenase
RRADSPS_RS05225	COG0527	aspartate kinase activity
RRADSPS_RS05230	COG0460	homoserine dehydrogenase
RRADSPS_RS05230	COG0527	aspartate kinase activity
RRADSPS_RS05235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RRADSPS_RS05280	COG0861	Integral membrane protein TerC family
RRADSPS_RS05285	COG0583	DNA-binding transcription factor activity
RRADSPS_RS05290	COG3485	protocatechuate 3,4-dioxygenase
RRADSPS_RS05295	COG3485	protocatechuate 3,4-dioxygenase
RRADSPS_RS05300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RRADSPS_RS05305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RRADSPS_RS05310	COG2814	Major facilitator Superfamily
RRADSPS_RS05320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RRADSPS_RS05325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RRADSPS_RS05360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RRADSPS_RS05395	COG1518	maintenance of DNA repeat elements
RRADSPS_RS05400	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RRADSPS_RS05405	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RRADSPS_RS05410	COG0446	pyridine nucleotide-disulphide oxidoreductase
RRADSPS_RS05425	COG0788	formyltetrahydrofolate deformylase activity
RRADSPS_RS05430	COG0124	histidyl-tRNA synthetase
RRADSPS_RS05435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RRADSPS_RS05440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RRADSPS_RS05450	COG0131	Imidazoleglycerol-phosphate dehydratase
RRADSPS_RS05455	COG1011	Hydrolase
RRADSPS_RS05460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RRADSPS_RS05465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RRADSPS_RS05475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RRADSPS_RS05500	COG1252	NADH dehydrogenase
RRADSPS_RS05545	COG0191	fructose-bisphosphate aldolase activity
RRADSPS_RS05555	COG1397	ADP-ribosylglycohydrolase
RRADSPS_RS05585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RRADSPS_RS05600	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RRADSPS_RS05630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RRADSPS_RS05645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RRADSPS_RS05650	COG0735	belongs to the Fur family
RRADSPS_RS05660	COG1121	(ABC) transporter
RRADSPS_RS05665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RRADSPS_RS05670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RRADSPS_RS05690	COG0523	cobalamin synthesis protein
RRADSPS_RS05700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RRADSPS_RS05710	COG0705	Rhomboid family
RRADSPS_RS05710	COG0457	Tetratricopeptide repeat
RRADSPS_RS05720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RRADSPS_RS05750	COG1231	oxidoreductase activity
RRADSPS_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS05760	COG0123	including yeast histone deacetylase and acetoin utilization protein
RRADSPS_RS05780	COG2309	aminopeptidase activity
RRADSPS_RS05790	COG0302	gtp cyclohydrolase
RRADSPS_RS05800	COG3842	ATPase activity
RRADSPS_RS05805	COG1178	ABC-type Fe3 transport system permease component
RRADSPS_RS05820	COG0494	nUDIX hydrolase
RRADSPS_RS05890	COG0432	Pfam Uncharacterised protein family UPF0047
RRADSPS_RS05900	COG1252	NADH dehydrogenase
RRADSPS_RS05905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RRADSPS_RS05915	COG0514	ATP-dependent DNA helicase (RecQ)
RRADSPS_RS05920	COG0693	protein deglycase activity
RRADSPS_RS05940	COG0616	signal peptide processing
RRADSPS_RS05945	COG2223	nitrite transmembrane transporter activity
RRADSPS_RS05950	COG2409	Drug exporters of the RND superfamily
RRADSPS_RS05955	COG0735	belongs to the Fur family
RRADSPS_RS05990	COG2197	response regulator
RRADSPS_RS06005	COG2372	response to copper ion
RRADSPS_RS06005	COG1276	copper resistance
RRADSPS_RS06020	COG0681	Belongs to the peptidase S26 family
RRADSPS_RS06060	COG0668	transmembrane transport
RRADSPS_RS06080	COG0671	phosphoesterase, PA-phosphatase related
RRADSPS_RS06085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RRADSPS_RS06100	COG1968	undecaprenyl-diphosphatase activity
RRADSPS_RS06105	COG1605	Chorismate mutase
RRADSPS_RS06105	COG0077	Prephenate dehydratase
RRADSPS_RS06120	COG1278	Cold shock
RRADSPS_RS06130	COG0588	phosphoglycerate mutase activity
RRADSPS_RS06145	COG2720	vancomycin resistance protein
RRADSPS_RS06155	COG1773	rubredoxin
RRADSPS_RS06155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RRADSPS_RS06180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RRADSPS_RS06190	COG3387	PFAM Glycoside hydrolase 15-related
RRADSPS_RS06205	COG1396	sequence-specific DNA binding
RRADSPS_RS06250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RRADSPS_RS06255	COG0045	succinate-CoA ligase (ADP-forming) activity
RRADSPS_RS06280	COG0346	lactoylglutathione lyase activity
RRADSPS_RS06295	COG0489	protein tyrosine kinase activity
RRADSPS_RS06295	COG2151	metal-sulfur cluster biosynthetic enzyme
RRADSPS_RS06300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RRADSPS_RS06305	COG0039	L-malate dehydrogenase activity
RRADSPS_RS06310	COG2816	NAD+ diphosphatase activity
RRADSPS_RS06315	COG0778	Nitroreductase
RRADSPS_RS06350	COG0473	3-isopropylmalate dehydrogenase activity
RRADSPS_RS06385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RRADSPS_RS06390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RRADSPS_RS06400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RRADSPS_RS06405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RRADSPS_RS06410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RRADSPS_RS06415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RRADSPS_RS06420	COG0072	phenylalanine-tRNA ligase activity
RRADSPS_RS06435	COG2094	Belongs to the DNA glycosylase MPG family
RRADSPS_RS06440	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RRADSPS_RS06445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RRADSPS_RS06465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RRADSPS_RS06470	COG0003	Pfam Anion-transporting ATPase
RRADSPS_RS06485	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
RRADSPS_RS06490	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RRADSPS_RS06495	COG0217	transcriptional regulatory protein
RRADSPS_RS06505	COG1278	Cold shock
RRADSPS_RS06510	COG0037	tRNA processing
RRADSPS_RS06510	COG0590	tRNA wobble adenosine to inosine editing
RRADSPS_RS06530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RRADSPS_RS06555	COG2351	hydroxyisourate hydrolase activity
RRADSPS_RS06565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RRADSPS_RS06575	COG1414	Transcriptional regulator
RRADSPS_RS06580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RRADSPS_RS06585	COG3622	Belongs to the hyi family
RRADSPS_RS06590	COG2084	Dehydrogenase
RRADSPS_RS06595	COG3960	tartronate-semialdehyde synthase activity
RRADSPS_RS06600	COG1272	protein, Hemolysin III
RRADSPS_RS06605	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RRADSPS_RS06610	COG0632	four-way junction helicase activity
RRADSPS_RS06615	COG2255	four-way junction helicase activity
RRADSPS_RS06645	COG0129	dihydroxy-acid dehydratase activity
RRADSPS_RS06655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RRADSPS_RS06660	COG0343	queuine tRNA-ribosyltransferase activity
RRADSPS_RS06665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RRADSPS_RS06670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RRADSPS_RS06685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RRADSPS_RS06695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RRADSPS_RS06700	COG0124	histidyl-tRNA synthetase
RRADSPS_RS06705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RRADSPS_RS06730	COG2226	methyltransferase
RRADSPS_RS06755	COG1271	oxidase subunit
RRADSPS_RS06770	COG4988	ABC transporter
RRADSPS_RS06775	COG1132	(ABC) transporter
RRADSPS_RS06780	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS06785	COG5002	protein histidine kinase activity
RRADSPS_RS06800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RRADSPS_RS06815	COG0482	sulfurtransferase activity
RRADSPS_RS06815	COG0822	iron-sulfur transferase activity
RRADSPS_RS06840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RRADSPS_RS06845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RRADSPS_RS06850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RRADSPS_RS06855	COG1459	type II secretion system
RRADSPS_RS06870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RRADSPS_RS06875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RRADSPS_RS06875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RRADSPS_RS06885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RRADSPS_RS06885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RRADSPS_RS06890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RRADSPS_RS06905	COG1307	EDD domain protein, DegV family
RRADSPS_RS06910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RRADSPS_RS06920	COG0742	ribosomal rna small subunit methyltransferase
RRADSPS_RS06925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RRADSPS_RS06940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RRADSPS_RS06945	COG0416	fatty acid biosynthetic process
RRADSPS_RS06950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RRADSPS_RS06955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RRADSPS_RS06960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RRADSPS_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS06970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RRADSPS_RS06975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RRADSPS_RS06980	COG0571	ribonuclease III activity
RRADSPS_RS06985	COG1196	nuclear chromosome segregation
RRADSPS_RS06990	COG0552	protein localization to endoplasmic reticulum
RRADSPS_RS07000	COG0228	four-way junction DNA binding
RRADSPS_RS07005	COG1837	Belongs to the UPF0109 family
RRADSPS_RS07010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RRADSPS_RS07015	COG0336	Belongs to the RNA methyltransferase TrmD family
RRADSPS_RS07020	COG0335	large ribosomal subunit rRNA binding
RRADSPS_RS07025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RRADSPS_RS07030	COG0792	nuclease activity
RRADSPS_RS07040	COG0758	DNA mediated transformation
RRADSPS_RS07045	COG1191	sigma factor activity
RRADSPS_RS07050	COG0052	Belongs to the universal ribosomal protein uS2 family
RRADSPS_RS07055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RRADSPS_RS07060	COG0528	UMP kinase activity
RRADSPS_RS07065	COG0233	cytoplasmic translational termination
RRADSPS_RS07070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RRADSPS_RS07080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RRADSPS_RS07085	COG0750	zinc metalloprotease
RRADSPS_RS07090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RRADSPS_RS07100	COG0779	Required for maturation of 30S ribosomal subunits
RRADSPS_RS07105	COG0195	Participates in both transcription termination and antitermination
RRADSPS_RS07110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RRADSPS_RS07120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RRADSPS_RS07125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RRADSPS_RS07130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RRADSPS_RS07135	COG0196	riboflavin kinase activity
RRADSPS_RS07140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RRADSPS_RS07145	COG1185	polyribonucleotide nucleotidyltransferase activity
RRADSPS_RS07150	COG0612	Peptidase, M16
RRADSPS_RS07155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RRADSPS_RS07170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RRADSPS_RS07180	COG1418	mRNA catabolic process
RRADSPS_RS07195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RRADSPS_RS07200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RRADSPS_RS07205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RRADSPS_RS07210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RRADSPS_RS07220	COG4974	Belongs to the 'phage' integrase family
RRADSPS_RS07225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RRADSPS_RS07245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RRADSPS_RS07250	COG1160	GTP binding
RRADSPS_RS07260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RRADSPS_RS07265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RRADSPS_RS07270	COG1187	pseudouridine synthase activity
RRADSPS_RS07275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RRADSPS_RS07285	COG0686	Belongs to the AlaDH PNT family
RRADSPS_RS07295	COG0504	CTP synthase activity
RRADSPS_RS07305	COG0463	Glycosyl transferase, family 2
RRADSPS_RS07320	COG0497	DNA recombination
RRADSPS_RS07325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RRADSPS_RS07340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RRADSPS_RS07345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RRADSPS_RS07350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RRADSPS_RS07355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RRADSPS_RS07360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RRADSPS_RS07365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RRADSPS_RS07395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RRADSPS_RS07400	COG0242	peptide deformylase activity
RRADSPS_RS07405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RRADSPS_RS07410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RRADSPS_RS07420	COG1758	RNA polymerase activity
RRADSPS_RS07425	COG0194	GDP metabolic process
RRADSPS_RS07435	COG0167	dihydroorotate dehydrogenase activity
RRADSPS_RS07440	COG0543	2 iron, 2 sulfur cluster binding
RRADSPS_RS07445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RRADSPS_RS07450	COG0505	Belongs to the CarA family
RRADSPS_RS07455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RRADSPS_RS07460	COG0540	Belongs to the ATCase OTCase family
RRADSPS_RS07465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RRADSPS_RS07470	COG0564	pseudouridine synthase activity
RRADSPS_RS07475	COG3599	regulation of cell shape
RRADSPS_RS07485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RRADSPS_RS07490	COG1799	cell septum assembly
RRADSPS_RS07495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RRADSPS_RS07505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RRADSPS_RS07520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RRADSPS_RS07525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RRADSPS_RS07530	COG0772	Belongs to the SEDS family
RRADSPS_RS07535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RRADSPS_RS07540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RRADSPS_RS07545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RRADSPS_RS07550	COG0768	penicillin binding
RRADSPS_RS07560	COG0275	rRNA processing
RRADSPS_RS07565	COG2001	Belongs to the MraZ family
RRADSPS_RS07580	COG0358	DNA primase activity
RRADSPS_RS07585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RRADSPS_RS07590	COG1381	Involved in DNA repair and RecF pathway recombination
RRADSPS_RS07595	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RRADSPS_RS07600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RRADSPS_RS07605	COG0295	cytidine deaminase activity
RRADSPS_RS07610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RRADSPS_RS07615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RRADSPS_RS07620	COG1480	7TM receptor with intracellular HD hydrolase
RRADSPS_RS07635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RRADSPS_RS07640	COG0484	heat shock protein binding
RRADSPS_RS07645	COG1420	regulation of RNA biosynthetic process
RRADSPS_RS07650	COG0481	GTPase activity
RRADSPS_RS07655	COG0268	Binds directly to 16S ribosomal RNA
RRADSPS_RS07665	COG0658	competence protein
RRADSPS_RS07665	COG2333	competence protein COMEC
RRADSPS_RS07685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RRADSPS_RS07690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RRADSPS_RS07695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RRADSPS_RS07700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RRADSPS_RS07710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RRADSPS_RS07710	COG2146	nitrite reductase [NAD(P)H] activity
RRADSPS_RS07715	COG0772	Belongs to the SEDS family
RRADSPS_RS07730	COG1077	Cell shape determining protein MreB Mrl
RRADSPS_RS07735	COG2003	Belongs to the UPF0758 family
RRADSPS_RS07740	COG0424	maF-like protein
RRADSPS_RS07745	COG0105	UTP biosynthetic process
RRADSPS_RS07755	COG0285	dihydrofolate synthase activity
RRADSPS_RS07765	COG0525	valine-tRNA ligase activity
RRADSPS_RS07770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RRADSPS_RS07775	COG0740	serine-type endopeptidase activity
RRADSPS_RS07780	COG0544	peptidyl-prolyl cis-trans isomerase activity
RRADSPS_RS07795	COG4651	solute:proton antiporter activity
RRADSPS_RS07795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RRADSPS_RS07800	COG1316	TRANSCRIPTIONal
RRADSPS_RS07835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RRADSPS_RS07840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RRADSPS_RS07845	COG0557	exoribonuclease II activity
RRADSPS_RS07850	COG2177	Part of the ABC transporter FtsEX involved in
RRADSPS_RS07855	COG2884	Cell division ATP-binding protein ftsE
RRADSPS_RS07865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RRADSPS_RS07870	COG0653	protein targeting
RRADSPS_RS07875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RRADSPS_RS07880	COG1040	competence protein
RRADSPS_RS07890	COG1007	ATP synthesis coupled electron transport
RRADSPS_RS07900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RRADSPS_RS07905	COG0713	ATP synthesis coupled electron transport
RRADSPS_RS07910	COG0839	Belongs to the complex I subunit 6 family
RRADSPS_RS07915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RRADSPS_RS07920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RRADSPS_RS07925	COG0649	NAD binding
RRADSPS_RS07935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RRADSPS_RS07940	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RRADSPS_RS07945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RRADSPS_RS07950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RRADSPS_RS07955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RRADSPS_RS07960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RRADSPS_RS07965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RRADSPS_RS07970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RRADSPS_RS07975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RRADSPS_RS07980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RRADSPS_RS07990	COG0356	it plays a direct role in the translocation of protons across the membrane
RRADSPS_RS08005	COG2131	deaminase
RRADSPS_RS08010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RRADSPS_RS08015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RRADSPS_RS08025	COG0009	L-threonylcarbamoyladenylate synthase
RRADSPS_RS08030	COG2890	protein-(glutamine-N5) methyltransferase activity
RRADSPS_RS08035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RRADSPS_RS08040	COG3872	metal-dependent enzyme
RRADSPS_RS08045	COG0254	rRNA binding
RRADSPS_RS08055	COG1494	fructose-1,6-bisphosphatase
RRADSPS_RS08060	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
RRADSPS_RS08085	COG0018	arginyl-trna synthetase
RRADSPS_RS08095	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RRADSPS_RS08100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RRADSPS_RS08120	COG1595	DNA-templated transcription, initiation
RRADSPS_RS08130	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RRADSPS_RS08135	COG1832	CoA-binding protein
RRADSPS_RS08145	COG1070	Carbohydrate kinase
RRADSPS_RS08150	COG0372	Belongs to the citrate synthase family
RRADSPS_RS08155	COG1335	isochorismatase
RRADSPS_RS08160	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RRADSPS_RS08170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RRADSPS_RS08175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RRADSPS_RS08180	COG1802	Transcriptional regulator
RRADSPS_RS08185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RRADSPS_RS08195	COG1366	Belongs to the anti-sigma-factor antagonist family
RRADSPS_RS08210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RRADSPS_RS08225	COG0205	6-phosphofructokinase activity
RRADSPS_RS08235	COG1960	acyl-CoA dehydrogenase activity
RRADSPS_RS08245	COG0791	NLP P60 protein
RRADSPS_RS08250	COG0318	PFAM AMP-dependent synthetase and ligase
RRADSPS_RS08260	COG1597	lipid kinase activity
RRADSPS_RS08265	COG2084	Dehydrogenase
RRADSPS_RS08275	COG3730	PTS system glucitol sorbitol-specific
RRADSPS_RS08280	COG3732	PTS system glucitol sorbitol-specific
RRADSPS_RS08300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RRADSPS_RS08305	COG0022	dehydrogenase e1 component
RRADSPS_RS08310	COG0508	dehydrogenase complex catalyzes the overall conversion of
RRADSPS_RS08320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RRADSPS_RS08335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RRADSPS_RS08335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RRADSPS_RS08335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RRADSPS_RS08340	COG1105	Belongs to the carbohydrate kinase PfkB family
RRADSPS_RS08345	COG1349	DNA-binding transcription factor activity
RRADSPS_RS08355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RRADSPS_RS08360	COG1960	acyl-CoA dehydrogenase activity
RRADSPS_RS08370	COG1024	Enoyl-CoA hydratase
RRADSPS_RS08380	COG1012	belongs to the aldehyde dehydrogenase family
RRADSPS_RS08440	COG2195	Cleaves the N-terminal amino acid of tripeptides
RRADSPS_RS08445	COG0477	Major facilitator Superfamily
RRADSPS_RS08450	COG0154	amidase activity
RRADSPS_RS08455	COG1012	belongs to the aldehyde dehydrogenase family
RRADSPS_RS08465	COG1024	Enoyl-CoA hydratase
RRADSPS_RS08480	COG1217	gtp-binding protein TYPA
RRADSPS_RS08495	COG0436	Aminotransferase
RRADSPS_RS08510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RRADSPS_RS08515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RRADSPS_RS08520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RRADSPS_RS08525	COG2080	2 iron, 2 sulfur cluster binding
RRADSPS_RS08535	COG0596	Alpha beta hydrolase
RRADSPS_RS08550	COG1937	Protein conserved in bacteria
RRADSPS_RS08605	COG0604	alcohol dehydrogenase
RRADSPS_RS08610	COG0402	S-adenosylhomocysteine deaminase activity
RRADSPS_RS08615	COG3485	protocatechuate 3,4-dioxygenase
RRADSPS_RS08620	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RRADSPS_RS08640	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RRADSPS_RS08645	COG0583	DNA-binding transcription factor activity
RRADSPS_RS08680	COG0726	polysaccharide deacetylase
RRADSPS_RS08695	COG0438	transferase activity, transferring glycosyl groups
RRADSPS_RS08710	COG0438	transferase activity, transferring glycosyl groups
RRADSPS_RS08715	COG0489	protein tyrosine kinase activity
RRADSPS_RS08720	COG3944	biosynthesis protein
RRADSPS_RS08730	COG2197	response regulator
RRADSPS_RS08740	COG0371	Dehydrogenase
RRADSPS_RS08755	COG1063	alcohol dehydrogenase
RRADSPS_RS08765	COG3191	aminopeptidase activity
RRADSPS_RS08780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RRADSPS_RS08785	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RRADSPS_RS08790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RRADSPS_RS08805	COG1575	Belongs to the MenA family. Type 1 subfamily
RRADSPS_RS08810	COG0805	protein transport
RRADSPS_RS08840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RRADSPS_RS08845	COG0113	porphobilinogen synthase activity
RRADSPS_RS08850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RRADSPS_RS08850	COG1587	Uroporphyrinogen-III synthase
RRADSPS_RS08855	COG0181	hydroxymethylbilane synthase activity
RRADSPS_RS08860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RRADSPS_RS08865	COG1648	precorrin-2 dehydrogenase activity
RRADSPS_RS08865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RRADSPS_RS08870	COG0521	Mo-molybdopterin cofactor biosynthetic process
RRADSPS_RS08870	COG0315	cyclic pyranopterin monophosphate synthase activity
RRADSPS_RS08905	COG3481	metal-dependent phosphohydrolase, HD sub domain
RRADSPS_RS08920	COG1653	transport
RRADSPS_RS08930	COG1472	Belongs to the glycosyl hydrolase 3 family
RRADSPS_RS08960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RRADSPS_RS08985	COG0149	triose-phosphate isomerase activity
RRADSPS_RS08990	COG0126	phosphoglycerate kinase activity
RRADSPS_RS08995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RRADSPS_RS09000	COG1481	regulation of sporulation
RRADSPS_RS09005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RRADSPS_RS09010	COG0435	Glutathione S-transferase
RRADSPS_RS09015	COG1660	Displays ATPase and GTPase activities
RRADSPS_RS09020	COG0322	excinuclease ABC activity
RRADSPS_RS09035	COG0531	amino acid
RRADSPS_RS09050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RRADSPS_RS09055	COG3835	regulator
RRADSPS_RS09060	COG0004	ammonium transporteR
RRADSPS_RS09070	COG1309	transcriptional regulator
RRADSPS_RS09075	COG0556	nucleotide-excision repair
RRADSPS_RS09085	COG0237	dephospho-CoA kinase activity
RRADSPS_RS09090	COG0539	negative regulation of cytoplasmic translation
RRADSPS_RS09095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RRADSPS_RS09095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RRADSPS_RS09130	COG0559	Belongs to the binding-protein-dependent transport system permease family
RRADSPS_RS09160	COG2154	pterin-4-alpha-carbinolamine dehydratase
RRADSPS_RS09170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RRADSPS_RS09175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RRADSPS_RS09180	COG1085	galactose-1-phosphate uridylyltransferase
RRADSPS_RS09185	COG2723	6-phospho-beta-galactosidase activity
RRADSPS_RS09190	COG1486	melibiose metabolic process
RRADSPS_RS09195	COG0395	ABC-type sugar transport system, permease component
RRADSPS_RS09200	COG1175	transmembrane transport
RRADSPS_RS09210	COG5578	integral membrane protein
RRADSPS_RS09220	COG0366	Alpha amylase catalytic
RRADSPS_RS09225	COG0667	Aldo Keto reductase
RRADSPS_RS09230	COG0318	PFAM AMP-dependent synthetase and ligase
RRADSPS_RS09250	COG5001	Diguanylate cyclase
RRADSPS_RS09255	COG2133	pyrroloquinoline quinone binding
RRADSPS_RS09260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RRADSPS_RS09265	COG0183	Belongs to the thiolase family
RRADSPS_RS09270	COG1024	Enoyl-CoA hydratase
RRADSPS_RS09270	COG1250	3-hydroxyacyl-CoA dehydrogenase
RRADSPS_RS09280	COG1695	Transcriptional regulator
RRADSPS_RS09285	COG1022	Amp-dependent synthetase and ligase
RRADSPS_RS09290	COG1960	acyl-CoA dehydrogenase activity
RRADSPS_RS09305	COG0596	Alpha beta hydrolase
RRADSPS_RS09310	COG0604	alcohol dehydrogenase
RRADSPS_RS09315	COG0523	cobalamin synthesis protein
RRADSPS_RS09330	COG0252	asparaginase activity
RRADSPS_RS09335	COG0346	lactoylglutathione lyase activity
RRADSPS_RS09340	COG2720	vancomycin resistance protein
RRADSPS_RS09345	COG2224	Isocitrate lyase
RRADSPS_RS09350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RRADSPS_RS09360	COG0583	DNA-binding transcription factor activity
RRADSPS_RS09370	COG0473	3-isopropylmalate dehydrogenase activity
RRADSPS_RS09380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
RRADSPS_RS09395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RRADSPS_RS09410	COG1115	amino acid carrier protein
RRADSPS_RS09430	COG0825	malonyl-CoA metabolic process
RRADSPS_RS09435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RRADSPS_RS09440	COG0159	tryptophan synthase activity
RRADSPS_RS09445	COG0133	tryptophan synthase activity
RRADSPS_RS09450	COG0135	phosphoribosylanthranilate isomerase activity
RRADSPS_RS09475	COG0134	indole-3-glycerol-phosphate synthase activity
RRADSPS_RS09480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RRADSPS_RS09500	COG1609	Transcriptional regulator
RRADSPS_RS09545	COG0747	negative chemotaxis
RRADSPS_RS09575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RRADSPS_RS09585	COG0784	Response regulator, receiver
RRADSPS_RS09595	COG0140	phosphoribosyl-ATP diphosphatase activity
RRADSPS_RS09595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RRADSPS_RS09600	COG0107	imidazoleglycerol-phosphate synthase activity
RRADSPS_RS09610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RRADSPS_RS09615	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RRADSPS_RS09620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RRADSPS_RS09625	COG4122	O-methyltransferase activity
RRADSPS_RS09630	COG0101	tRNA pseudouridine synthase activity
RRADSPS_RS09635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RRADSPS_RS09640	COG1122	ATPase activity
RRADSPS_RS09645	COG1122	ATPase activity
RRADSPS_RS09650	COG0203	ribosomal protein L17
RRADSPS_RS09655	COG0202	RNA polymerase activity
RRADSPS_RS09660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RRADSPS_RS09665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RRADSPS_RS09670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RRADSPS_RS09675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RRADSPS_RS09680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RRADSPS_RS09685	COG0024	Methionine aminopeptidase
RRADSPS_RS09690	COG0563	adenylate kinase activity
RRADSPS_RS09700	COG0200	Binds to the 23S rRNA
RRADSPS_RS09705	COG1841	ribosomal large subunit assembly
RRADSPS_RS09710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RRADSPS_RS09715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RRADSPS_RS09720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RRADSPS_RS09725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RRADSPS_RS09730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RRADSPS_RS09735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RRADSPS_RS09740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RRADSPS_RS09745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RRADSPS_RS09750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RRADSPS_RS09755	COG0255	Belongs to the universal ribosomal protein uL29 family
RRADSPS_RS09760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RRADSPS_RS09765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RRADSPS_RS09770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RRADSPS_RS09775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RRADSPS_RS09780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RRADSPS_RS09785	COG0089	rRNA binding
RRADSPS_RS09790	COG0088	Forms part of the polypeptide exit tunnel
RRADSPS_RS09795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RRADSPS_RS09800	COG0051	transcription antitermination factor activity, RNA binding
RRADSPS_RS09805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RRADSPS_RS09810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RRADSPS_RS09815	COG0049	tRNA binding
RRADSPS_RS09820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RRADSPS_RS09825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RRADSPS_RS09835	COG0222	ribosome binding
RRADSPS_RS09840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RRADSPS_RS09845	COG0081	regulation of translation
RRADSPS_RS09850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RRADSPS_RS09870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RRADSPS_RS09900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RRADSPS_RS09905	COG0215	cysteine-tRNA ligase activity
RRADSPS_RS09910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RRADSPS_RS09915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RRADSPS_RS09920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RRADSPS_RS09925	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RRADSPS_RS09930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RRADSPS_RS09950	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
RRADSPS_RS09955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RRADSPS_RS09965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RRADSPS_RS09970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RRADSPS_RS09980	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RRADSPS_RS09985	COG0037	tRNA processing
RRADSPS_RS09995	COG4129	membrane
RRADSPS_RS10000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RRADSPS_RS10005	COG1653	transport
RRADSPS_RS10025	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RRADSPS_RS10030	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RRADSPS_RS10065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RRADSPS_RS10080	COG0012	GTP binding
RRADSPS_RS10125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RRADSPS_RS10130	COG4968	Prepilin-type N-terminal cleavage methylation domain
RRADSPS_RS10155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RRADSPS_RS10160	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS10165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RRADSPS_RS10170	COG0655	NAD(P)H dehydrogenase (quinone) activity
RRADSPS_RS10175	COG0346	lactoylglutathione lyase activity
RRADSPS_RS10180	COG1846	Transcriptional regulator
RRADSPS_RS10220	COG0582	viral genome integration into host DNA
RRADSPS_RS10235	COG0583	DNA-binding transcription factor activity
RRADSPS_RS10255	COG2897	thiosulfate sulfurtransferase activity
RRADSPS_RS10265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RRADSPS_RS10270	COG0475	glutathione-regulated potassium exporter activity
RRADSPS_RS10280	COG3842	ATPase activity
RRADSPS_RS10285	COG0398	Pfam SNARE associated Golgi protein
RRADSPS_RS10290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RRADSPS_RS10295	COG0395	ABC-type sugar transport system, permease component
RRADSPS_RS10305	COG4134	Bacterial extracellular solute-binding protein
RRADSPS_RS10340	COG1252	NADH dehydrogenase
RRADSPS_RS10375	COG0318	PFAM AMP-dependent synthetase and ligase
RRADSPS_RS10380	COG0318	PFAM AMP-dependent synthetase and ligase
RRADSPS_RS10390	COG1764	response to oxidative stress
RRADSPS_RS10410	COG1024	Enoyl-CoA hydratase
RRADSPS_RS10415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RRADSPS_RS10415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RRADSPS_RS10425	COG0446	pyridine nucleotide-disulphide oxidoreductase
RRADSPS_RS10430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RRADSPS_RS10440	COG0726	polysaccharide deacetylase
RRADSPS_RS10445	COG0259	pyridoxamine-phosphate oxidase activity
RRADSPS_RS10455	COG0251	oxidation-reduction process
RRADSPS_RS10465	COG0247	lactate metabolic process
RRADSPS_RS10465	COG0277	FAD linked oxidase domain protein
RRADSPS_RS10470	COG0367	asparagine synthase
RRADSPS_RS10485	COG1012	belongs to the aldehyde dehydrogenase family
RRADSPS_RS10490	COG4948	Mandelate Racemase Muconate Lactonizing
RRADSPS_RS10500	COG1174	glycine betaine transport
RRADSPS_RS10505	COG1125	glycine betaine transport
RRADSPS_RS10505	COG0517	IMP dehydrogenase activity
RRADSPS_RS10510	COG1174	glycine betaine transport
RRADSPS_RS10520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RRADSPS_RS10530	COG0318	PFAM AMP-dependent synthetase and ligase
RRADSPS_RS10540	COG3243	poly(R)-hydroxyalkanoic acid synthase
RRADSPS_RS10545	COG3119	arylsulfatase activity
RRADSPS_RS10555	COG3243	poly(R)-hydroxyalkanoic acid synthase
RRADSPS_RS10560	COG1960	acyl-CoA dehydrogenase activity
RRADSPS_RS10575	COG2409	Drug exporters of the RND superfamily
RRADSPS_RS10590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RRADSPS_RS10630	COG2197	response regulator
RRADSPS_RS10635	COG1960	acyl-CoA dehydrogenase activity
RRADSPS_RS10650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RRADSPS_RS10655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RRADSPS_RS10695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RRADSPS_RS10710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RRADSPS_RS10720	COG0720	synthase
RRADSPS_RS10725	COG1063	alcohol dehydrogenase
RRADSPS_RS10730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RRADSPS_RS10730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RRADSPS_RS10735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RRADSPS_RS10765	COG0842	Transport permease protein
RRADSPS_RS10770	COG1131	(ABC) transporter
RRADSPS_RS10780	COG0551	DNA topoisomerase type I activity
RRADSPS_RS10780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RRADSPS_RS10790	COG1295	ribonuclease BN
RRADSPS_RS10805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RRADSPS_RS10810	COG0667	Aldo Keto reductase
RRADSPS_RS10815	COG3253	May function as heme-dependent peroxidase
RRADSPS_RS10820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RRADSPS_RS10830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RRADSPS_RS10855	COG0537	adenosine 5'-monophosphoramidase activity
RRADSPS_RS10860	COG1363	Peptidase, m42
RRADSPS_RS10885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RRADSPS_RS10895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RRADSPS_RS10910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RRADSPS_RS10915	COG0287	Prephenate dehydrogenase
RRADSPS_RS10940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RRADSPS_RS10945	COG1090	epimerase
RRADSPS_RS10970	COG0616	signal peptide processing
RRADSPS_RS10985	COG0730	response to heat
RRADSPS_RS11000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RRADSPS_RS11005	COG0121	glutamine amidotransferase
RRADSPS_RS11015	COG1132	(ABC) transporter
RRADSPS_RS11020	COG1132	(ABC) transporter
RRADSPS_RS11025	COG1090	epimerase
RRADSPS_RS11035	COG3546	catalase activity
RRADSPS_RS11040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RRADSPS_RS11050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RRADSPS_RS11055	COG0656	L-ascorbic acid biosynthetic process
RRADSPS_RS11060	COG1070	Carbohydrate kinase
RRADSPS_RS11110	COG1192	Involved in chromosome partitioning
RRADSPS_RS11150	COG0508	dehydrogenase complex catalyzes the overall conversion of
RRADSPS_RS11165	COG0484	heat shock protein binding
RRADSPS_RS11190	COG1595	DNA-templated transcription, initiation
RRADSPS_RS11205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RRADSPS_RS11210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RRADSPS_RS11230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RRADSPS_RS11235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RRADSPS_RS11235	COG1321	iron dependent repressor
RRADSPS_RS11240	COG1121	(ABC) transporter
RRADSPS_RS11245	COG0803	Belongs to the bacterial solute-binding protein 9 family
RRADSPS_RS11250	COG1321	iron dependent repressor
RRADSPS_RS11260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RRADSPS_RS11265	COG4221	oxidoreductase activity
RRADSPS_RS11295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RRADSPS_RS11305	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS11315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RRADSPS_RS11320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RRADSPS_RS11335	COG0813	purine-nucleoside phosphorylase activity
RRADSPS_RS11340	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RRADSPS_RS11345	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RRADSPS_RS11355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RRADSPS_RS11365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RRADSPS_RS11370	COG1435	thymidine kinase activity
RRADSPS_RS11375	COG0398	Pfam SNARE associated Golgi protein
RRADSPS_RS11380	COG2301	Belongs to the HpcH HpaI aldolase family
RRADSPS_RS11395	COG1725	Transcriptional regulator
RRADSPS_RS11400	COG1131	(ABC) transporter
RRADSPS_RS11425	COG0247	lactate metabolic process
RRADSPS_RS11430	COG0277	FAD linked oxidase domain protein
RRADSPS_RS11435	COG0277	FAD linked oxidase domain protein
RRADSPS_RS11440	COG2379	hydroxypyruvate reductase
RRADSPS_RS11445	COG1620	l-lactate permease
RRADSPS_RS11450	COG1620	l-lactate permease
RRADSPS_RS11455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RRADSPS_RS11485	COG0405	Gamma-glutamyltransferase
RRADSPS_RS11525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RRADSPS_RS11540	COG0114	fumarate hydratase activity
RRADSPS_RS11570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RRADSPS_RS11585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RRADSPS_RS11595	COG0137	argininosuccinate synthase activity
RRADSPS_RS11610	COG1438	arginine binding
RRADSPS_RS11615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RRADSPS_RS11620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RRADSPS_RS11625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RRADSPS_RS11630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RRADSPS_RS11635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RRADSPS_RS11645	COG0110	maltose O-acetyltransferase activity
RRADSPS_RS11660	COG1653	transport
RRADSPS_RS11680	COG1441	menaquinone biosynthetic process
RRADSPS_RS11685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RRADSPS_RS11690	COG0596	Alpha beta hydrolase
RRADSPS_RS11705	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RRADSPS_RS11720	COG1268	BioY protein
RRADSPS_RS11735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RRADSPS_RS11760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RRADSPS_RS11795	COG3153	acetyltransferase
RRADSPS_RS11860	COG2340	Cysteine-rich secretory protein family
RRADSPS_RS11880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RRADSPS_RS11905	COG0420	3'-5' exonuclease activity
RRADSPS_RS11920	COG3402	PFAM membrane-flanked domain
RRADSPS_RS11925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RRADSPS_RS11960	COG0243	molybdopterin cofactor binding
RRADSPS_RS11985	COG2124	cytochrome p450
RRADSPS_RS11990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RRADSPS_RS11995	COG3387	PFAM Glycoside hydrolase 15-related
RRADSPS_RS12000	COG1012	belongs to the aldehyde dehydrogenase family
RRADSPS_RS12005	COG0071	Belongs to the small heat shock protein (HSP20) family
RRADSPS_RS12030	COG1131	(ABC) transporter
RRADSPS_RS12050	COG1966	Carbon starvation protein
RRADSPS_RS12065	COG0003	Pfam Anion-transporting ATPase
RRADSPS_RS12080	COG1120	ATPase activity
RRADSPS_RS12085	COG4636	protein conserved in cyanobacteria
RRADSPS_RS12090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RRADSPS_RS12095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RRADSPS_RS12100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RRADSPS_RS12115	COG0438	transferase activity, transferring glycosyl groups
RRADSPS_RS12150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RRADSPS_RS12155	COG1234	tRNA 3'-trailer cleavage
RRADSPS_RS12170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RRADSPS_RS12170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RRADSPS_RS12190	COG1253	flavin adenine dinucleotide binding
RRADSPS_RS12195	COG1132	(ABC) transporter
RRADSPS_RS12205	COG1051	belongs to the nudix hydrolase family
RRADSPS_RS12215	COG0316	Belongs to the HesB IscA family
RRADSPS_RS12230	COG0714	Associated with various cellular activities
RRADSPS_RS12240	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS12260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RRADSPS_RS12275	COG0352	thiamine-phosphate diphosphorylase activity
RRADSPS_RS12280	COG3361	conserved protein (COG2071)
RRADSPS_RS12290	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RRADSPS_RS12295	COG0352	thiamine-phosphate diphosphorylase activity
RRADSPS_RS12295	COG0351	phosphomethylpyrimidine kinase
RRADSPS_RS12305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RRADSPS_RS12310	COG1116	anion transmembrane transporter activity
RRADSPS_RS12315	COG3859	Proton-coupled thiamine transporter YuaJ
RRADSPS_RS12335	COG2814	Major facilitator Superfamily
RRADSPS_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS12350	COG2897	thiosulfate sulfurtransferase activity
RRADSPS_RS12355	COG0617	tRNA 3'-terminal CCA addition
RRADSPS_RS12360	COG1366	Belongs to the anti-sigma-factor antagonist family
RRADSPS_RS12375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RRADSPS_RS12380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RRADSPS_RS12385	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS12400	COG2271	Major facilitator Superfamily
RRADSPS_RS12410	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RRADSPS_RS12420	COG0191	fructose-bisphosphate aldolase activity
RRADSPS_RS12425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RRADSPS_RS12430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RRADSPS_RS12435	COG1172	Belongs to the binding-protein-dependent transport system permease family
RRADSPS_RS12455	COG0022	dehydrogenase e1 component
RRADSPS_RS12460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RRADSPS_RS12465	COG1063	alcohol dehydrogenase
RRADSPS_RS12470	COG2195	Cleaves the N-terminal amino acid of tripeptides
RRADSPS_RS12475	COG3246	L-lysine catabolic process to acetate
RRADSPS_RS12480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RRADSPS_RS12490	COG1070	Carbohydrate kinase
RRADSPS_RS12510	COG0022	dehydrogenase e1 component
RRADSPS_RS12515	COG0508	dehydrogenase complex catalyzes the overall conversion of
RRADSPS_RS12520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RRADSPS_RS12525	COG1070	Carbohydrate kinase
RRADSPS_RS12530	COG0071	Belongs to the small heat shock protein (HSP20) family
RRADSPS_RS12545	COG0405	Gamma-glutamyltransferase
RRADSPS_RS12575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RRADSPS_RS12660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RRADSPS_RS12675	COG0586	Pfam SNARE associated Golgi protein
RRADSPS_RS12685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RRADSPS_RS12690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RRADSPS_RS12700	COG2814	Major facilitator Superfamily
RRADSPS_RS12710	COG1522	sequence-specific DNA binding
RRADSPS_RS12715	COG1573	uracil-dna glycosylase
RRADSPS_RS12725	COG2358	TRAP transporter, solute receptor (TAXI family
RRADSPS_RS12740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RRADSPS_RS12745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RRADSPS_RS12750	COG0765	amino acid transport
RRADSPS_RS12760	COG1595	DNA-templated transcription, initiation
RRADSPS_RS12790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RRADSPS_RS12835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RRADSPS_RS12855	COG1401	restriction endodeoxyribonuclease activity
RRADSPS_RS12865	COG0210	DNA helicase
RRADSPS_RS12875	COG2378	regulation of single-species biofilm formation
RRADSPS_RS12885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RRADSPS_RS12890	COG2755	lipolytic protein G-D-S-L family
RRADSPS_RS12890	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RRADSPS_RS12905	COG0069	glutamate synthase activity
RRADSPS_RS12905	COG0070	glutamate synthase
RRADSPS_RS12905	COG0067	glutamate synthase
RRADSPS_RS12915	COG1250	3-hydroxyacyl-CoA dehydrogenase
RRADSPS_RS12940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RRADSPS_RS12945	COG1993	acr, cog1993
RRADSPS_RS12965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RRADSPS_RS12980	COG0437	4 iron, 4 sulfur cluster binding
RRADSPS_RS12990	COG3383	formate dehydrogenase (NAD+) activity
RRADSPS_RS12990	COG0243	molybdopterin cofactor binding
RRADSPS_RS13000	COG1063	alcohol dehydrogenase
RRADSPS_RS13005	COG0667	Aldo Keto reductase
RRADSPS_RS13015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RRADSPS_RS13025	COG2223	nitrite transmembrane transporter activity
RRADSPS_RS13030	COG3383	formate dehydrogenase (NAD+) activity
RRADSPS_RS13035	COG3383	formate dehydrogenase (NAD+) activity
RRADSPS_RS13040	COG3162	membrane
RRADSPS_RS13045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RRADSPS_RS13050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RRADSPS_RS13050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RRADSPS_RS13060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RRADSPS_RS13065	COG1764	response to oxidative stress
RRADSPS_RS13080	COG1929	Belongs to the glycerate kinase type-1 family
RRADSPS_RS13085	COG1335	isochorismatase
RRADSPS_RS13115	COG2217	Heavy metal translocating P-type atpase
RRADSPS_RS13130	COG0628	permease
RRADSPS_RS13135	COG3243	poly(R)-hydroxyalkanoic acid synthase
RRADSPS_RS13185	COG1764	response to oxidative stress
RRADSPS_RS13195	COG0028	Belongs to the TPP enzyme family
RRADSPS_RS13205	COG0596	Alpha beta hydrolase
RRADSPS_RS13230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RRADSPS_RS13330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RRADSPS_RS13340	COG0735	belongs to the Fur family
RRADSPS_RS13365	COG1122	ATPase activity
RRADSPS_RS13380	COG4251	negative regulation of phosphorylation
RRADSPS_RS13415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RRADSPS_RS13420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RRADSPS_RS13425	COG2076	Multidrug Resistance protein
RRADSPS_RS13435	COG2197	response regulator
RRADSPS_RS13455	COG1131	(ABC) transporter
RRADSPS_RS13485	COG0019	diaminopimelate decarboxylase activity
RRADSPS_RS13490	COG0436	Aminotransferase
RRADSPS_RS13495	COG2171	N-acyltransferase activity
RRADSPS_RS13500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RRADSPS_RS13505	COG1653	transport
RRADSPS_RS13515	COG1131	(ABC) transporter
RRADSPS_RS13530	COG0598	Magnesium transport protein CorA
RRADSPS_RS13550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RRADSPS_RS13595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RRADSPS_RS13605	COG0745	RESPONSE REGULATOR receiver
RRADSPS_RS13615	COG1132	(ABC) transporter
RRADSPS_RS13620	COG0515	serine threonine protein kinase
RRADSPS_RS13635	COG1132	(ABC) transporter
RRADSPS_RS13645	COG0438	transferase activity, transferring glycosyl groups
RRADSPS_RS13680	COG1473	amidohydrolase
RRADSPS_RS13685	COG1725	Transcriptional regulator
RRADSPS_RS13690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RRADSPS_RS13705	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
RRADSPS_RS13710	COG1278	Cold shock
RRADSPS_RS13730	COG0396	ATPase activity
RRADSPS_RS13735	COG0719	Fe-S assembly protein
RRADSPS_RS13740	COG0719	Fe-S assembly protein
RRADSPS_RS13750	COG3791	Glutathione-dependent formaldehyde-activating
RRADSPS_RS13755	COG0822	iron-sulfur transferase activity
RRADSPS_RS13760	COG0402	S-adenosylhomocysteine deaminase activity
RRADSPS_RS13785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RRADSPS_RS13790	COG0484	heat shock protein binding
RRADSPS_RS13810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
RRADSPS_RS13815	COG0789	Transcriptional regulator
RRADSPS_RS13820	COG0509	glycine decarboxylation via glycine cleavage system
RRADSPS_RS13825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RRADSPS_RS13830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RRADSPS_RS13835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RRADSPS_RS13855	COG1028	Short-chain dehydrogenase reductase Sdr
RRADSPS_RS13860	COG1012	belongs to the aldehyde dehydrogenase family
RRADSPS_RS13865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RRADSPS_RS13875	COG0531	amino acid
RRADSPS_RS13885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RRADSPS_RS13890	COG2200	EAL domain
RRADSPS_RS13900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RRADSPS_RS13905	COG2197	response regulator
RRADSPS_RS13910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RRADSPS_RS13915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RRADSPS_RS13920	COG0495	leucyl-tRNA aminoacylation
RRADSPS_RS13925	COG1836	PFAM Integral membrane protein DUF92
RRADSPS_RS13950	COG1475	DNA binding
RRADSPS_RS13955	COG1192	Involved in chromosome partitioning
RRADSPS_RS13960	COG0357	Ribosomal RNA small subunit methyltransferase G
RRADSPS_RS13965	COG1847	R3H domain protein
RRADSPS_RS13970	COG0706	membrane insertase activity
RRADSPS_RS13980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RRADSPS_RS14010	COG0592	DNA-directed DNA polymerase activity
RRADSPS_RS14180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RRADSPS_RS14590	COG3845	ABC transporter
RRADSPS_RS14830	COG0542	response to heat
RRADSPS_RS15395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RRADSPS_RS15795	COG0517	IMP dehydrogenase activity
RRADSPS_RS15795	COG4175	Glycine betaine
RRADSPS_RS15805	COG0631	protein serine/threonine phosphatase activity
RRADSPS_RS15815	COG2815	serine threonine protein kinase
RRADSPS_RS15815	COG0515	serine threonine protein kinase
RRADSPS_RS15820	COG0628	permease
RRADSPS_RS15830	COG0823	Involved in the tonB-independent uptake of proteins
RRADSPS_RS15835	COG0671	phosphoesterase, PA-phosphatase related
RRADSPS_RS15855	COG4251	negative regulation of phosphorylation
RRADSPS_RS15860	COG5001	Diguanylate cyclase
RRADSPS_RS15865	COG0791	NLP P60 protein
RRADSPS_RS15865	COG1388	LysM domain
RRADSPS_RS15870	COG1876	peptidase activity
RRADSPS_RS15885	COG0668	transmembrane transport
RRADSPS_RS15930	COG1597	lipid kinase activity
RRADSPS_RS15945	COG2045	Belongs to the ComB family
RRADSPS_RS15950	COG2226	methyltransferase
RRADSPS_RS15955	COG1686	Belongs to the peptidase S11 family
RRADSPS_RS15985	COG0586	Pfam SNARE associated Golgi protein
RRADSPS_RS15995	COG2045	Belongs to the ComB family
RRADSPS_RS16010	COG5002	protein histidine kinase activity
RRADSPS_RS16060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RRADSPS_RS16085	COG5001	Diguanylate cyclase
RRADSPS_RS16090	COG0778	Nitroreductase
RRADSPS_RS16100	COG0789	Transcriptional regulator
RRADSPS_RS16105	COG5002	protein histidine kinase activity
RRADSPS_RS16105	COG3447	MASE1 domain protein
RRADSPS_RS16105	COG5001	Diguanylate cyclase
RRADSPS_RS16165	COG2226	methyltransferase
RRADSPS_RS16170	COG1216	Glycosyl transferase, family 2
RRADSPS_RS16230	COG1674	ftsk spoiiie
RRADSPS_RS16240	COG2137	regulation of response to DNA damage stimulus
RRADSPS_RS16275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RRADSPS_RS16305	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
RRADSPS_RS16310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RRADSPS_RS16320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RRADSPS_RS16325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RRADSPS_RS16330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RRADSPS_RS16365	COG4585	Histidine kinase
RRADSPS_RS16395	COG0515	serine threonine protein kinase
RRADSPS_RS16495	COG5002	protein histidine kinase activity
RRADSPS_RS16500	COG5002	protein histidine kinase activity
RRADSPS_RS16500	COG2205	protein histidine kinase activity
RRADSPS_RS16500	COG0784	Response regulator, receiver
RRADSPS_RS16530	COG0515	serine threonine protein kinase
RRADSPS_RS16545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RRADSPS_RS16550	COG2508	Transcriptional regulator
RRADSPS_RS16555	COG0494	nUDIX hydrolase
RRADSPS_RS16565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RRADSPS_RS16565	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RRADSPS_RS16580	COG1695	Transcriptional regulator
RRADSPS_RS16585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RRADSPS_RS16590	COG5002	protein histidine kinase activity
RRADSPS_RS16595	COG1215	transferase activity, transferring glycosyl groups
RRADSPS_RS16605	COG2188	Transcriptional regulator