locus-tag	class	description
RxyAA322_RS00005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RxyAA322_RS00015	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RxyAA322_RS00020	COG2815	serine threonine protein kinase
RxyAA322_RS00020	COG0515	serine threonine protein kinase
RxyAA322_RS00025	COG2815	serine threonine protein kinase
RxyAA322_RS00025	COG0515	serine threonine protein kinase
RxyAA322_RS00035	COG1278	Cold shock
RxyAA322_RS00040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RxyAA322_RS00050	COG0671	phosphoesterase, PA-phosphatase related
RxyAA322_RS00060	COG1363	Peptidase, m42
RxyAA322_RS00070	COG0537	adenosine 5'-monophosphoramidase activity
RxyAA322_RS00095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RxyAA322_RS00105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RxyAA322_RS00110	COG3253	May function as heme-dependent peroxidase
RxyAA322_RS00115	COG0667	Aldo Keto reductase
RxyAA322_RS00120	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RxyAA322_RS00125	COG2045	Belongs to the ComB family
RxyAA322_RS00140	COG1295	ribonuclease BN
RxyAA322_RS00145	COG0551	DNA topoisomerase type I activity
RxyAA322_RS00145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RxyAA322_RS00155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RxyAA322_RS00155	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RxyAA322_RS00160	COG1131	(ABC) transporter
RxyAA322_RS00165	COG0842	Transport permease protein
RxyAA322_RS00180	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS00190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RxyAA322_RS00205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RxyAA322_RS00215	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RxyAA322_RS00220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RxyAA322_RS00235	COG3119	arylsulfatase activity
RxyAA322_RS00260	COG0423	glycine-tRNA ligase activity
RxyAA322_RS00295	COG5002	protein histidine kinase activity
RxyAA322_RS00300	COG0745	RESPONSE REGULATOR receiver
RxyAA322_RS00305	COG0443	Heat shock 70 kDa protein
RxyAA322_RS00310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RxyAA322_RS00315	COG0484	heat shock protein binding
RxyAA322_RS00320	COG0789	Transcriptional regulator
RxyAA322_RS00355	COG1254	Belongs to the acylphosphatase family
RxyAA322_RS00360	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RxyAA322_RS00370	COG0456	acetyltransferase
RxyAA322_RS00375	COG0456	acetyltransferase
RxyAA322_RS00380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RxyAA322_RS00385	COG1597	lipid kinase activity
RxyAA322_RS00390	COG0736	holo-[acyl-carrier-protein] synthase activity
RxyAA322_RS00395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RxyAA322_RS00395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RxyAA322_RS00400	COG0517	IMP dehydrogenase activity
RxyAA322_RS00400	COG0617	tRNA 3'-terminal CCA addition
RxyAA322_RS00400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RxyAA322_RS00405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RxyAA322_RS00410	COG0617	tRNA 3'-terminal CCA addition
RxyAA322_RS00410	COG1353	crispr-associated protein
RxyAA322_RS00420	COG1573	uracil-dna glycosylase
RxyAA322_RS00425	COG0802	atpase or kinase
RxyAA322_RS00445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RxyAA322_RS00460	COG0459	protein refolding
RxyAA322_RS00465	COG0516	GMP reductase activity
RxyAA322_RS00470	COG0519	Catalyzes the synthesis of GMP from XMP
RxyAA322_RS00470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RxyAA322_RS00485	COG0573	inorganic phosphate transmembrane transporter activity
RxyAA322_RS00495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RxyAA322_RS00505	COG1959	2 iron, 2 sulfur cluster binding
RxyAA322_RS00525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RxyAA322_RS00530	COG5640	endopeptidase activity
RxyAA322_RS00535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RxyAA322_RS00540	COG0154	amidase activity
RxyAA322_RS00545	COG1609	Transcriptional regulator
RxyAA322_RS00555	COG1070	Carbohydrate kinase
RxyAA322_RS00560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RxyAA322_RS00570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RxyAA322_RS00575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RxyAA322_RS00605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RxyAA322_RS00615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RxyAA322_RS00615	COG0646	methionine synthase
RxyAA322_RS00620	COG1562	ergosterol biosynthetic process
RxyAA322_RS00630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RxyAA322_RS00645	COG0577	efflux transmembrane transporter activity
RxyAA322_RS00645	COG1136	(ABC) transporter
RxyAA322_RS00650	COG0360	Binds together with S18 to 16S ribosomal RNA
RxyAA322_RS00655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RxyAA322_RS00660	COG0359	binds to the 23S rRNA
RxyAA322_RS00665	COG0305	Participates in initiation and elongation during chromosome replication
RxyAA322_RS00685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RxyAA322_RS00695	COG2738	Putative neutral zinc metallopeptidase
RxyAA322_RS00705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RxyAA322_RS00720	COG1595	DNA-templated transcription, initiation
RxyAA322_RS00740	COG0747	negative chemotaxis
RxyAA322_RS00745	COG0601	transmembrane transport
RxyAA322_RS00750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RxyAA322_RS00755	COG0444	Belongs to the ABC transporter superfamily
RxyAA322_RS00760	COG4608	Belongs to the ABC transporter superfamily
RxyAA322_RS00780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RxyAA322_RS00790	COG1846	Transcriptional regulator
RxyAA322_RS00805	COG0723	plastoquinol--plastocyanin reductase activity
RxyAA322_RS00830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RxyAA322_RS00835	COG0084	hydrolase, TatD family'
RxyAA322_RS00840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RxyAA322_RS00845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RxyAA322_RS00855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RxyAA322_RS00860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RxyAA322_RS00865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RxyAA322_RS00870	COG0193	aminoacyl-tRNA hydrolase activity
RxyAA322_RS00875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RxyAA322_RS00890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RxyAA322_RS00900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RxyAA322_RS00915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RxyAA322_RS00920	COG1733	regulation of RNA biosynthetic process
RxyAA322_RS00925	COG2259	Doxx family
RxyAA322_RS00930	COG2050	protein possibly involved in aromatic compounds catabolism
RxyAA322_RS00940	COG1683	Conserved Protein
RxyAA322_RS00945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RxyAA322_RS00950	COG0148	phosphopyruvate hydratase activity
RxyAA322_RS00995	COG0674	pyruvate-flavodoxin oxidoreductase activity
RxyAA322_RS01000	COG1013	pyruvate-flavodoxin oxidoreductase activity
RxyAA322_RS01010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RxyAA322_RS01025	COG0861	Integral membrane protein TerC family
RxyAA322_RS01085	COG0517	IMP dehydrogenase activity
RxyAA322_RS01115	COG2815	serine threonine protein kinase
RxyAA322_RS01115	COG0515	serine threonine protein kinase
RxyAA322_RS01130	COG1609	Transcriptional regulator
RxyAA322_RS01135	COG1129	ABC transporter
RxyAA322_RS01140	COG1172	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS01145	COG1879	ABC-type sugar transport system periplasmic component
RxyAA322_RS01155	COG1869	D-ribose catabolic process
RxyAA322_RS01160	COG2391	methyltransferase activity
RxyAA322_RS01180	COG2095	MarC family integral membrane protein
RxyAA322_RS01185	COG0823	Involved in the tonB-independent uptake of proteins
RxyAA322_RS01185	COG1506	peptidase
RxyAA322_RS01190	COG0095	Lipoate-protein ligase
RxyAA322_RS01195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RxyAA322_RS01200	COG1920	GTP binding
RxyAA322_RS01205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RxyAA322_RS01215	COG0175	sulfate reduction
RxyAA322_RS01220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RxyAA322_RS01235	COG2046	Belongs to the sulfate adenylyltransferase family
RxyAA322_RS01240	COG0529	Catalyzes the synthesis of activated sulfate
RxyAA322_RS01245	COG0730	response to heat
RxyAA322_RS01250	COG0346	lactoylglutathione lyase activity
RxyAA322_RS01265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RxyAA322_RS01280	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RxyAA322_RS01285	COG2897	thiosulfate sulfurtransferase activity
RxyAA322_RS01295	COG1309	transcriptional regulator
RxyAA322_RS01300	COG2409	Drug exporters of the RND superfamily
RxyAA322_RS01305	COG0165	Argininosuccinate lyase
RxyAA322_RS01325	COG1174	glycine betaine transport
RxyAA322_RS01330	COG1174	glycine betaine transport
RxyAA322_RS01365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RxyAA322_RS01375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RxyAA322_RS01390	COG0047	phosphoribosylformylglycinamidine synthase activity
RxyAA322_RS01395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RxyAA322_RS01400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RxyAA322_RS01405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RxyAA322_RS01410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RxyAA322_RS01415	COG0138	bifunctional purine biosynthesis protein purh
RxyAA322_RS01445	COG3118	belongs to the thioredoxin family
RxyAA322_RS01455	COG0582	viral genome integration into host DNA
RxyAA322_RS01485	COG3328	transposase activity
RxyAA322_RS01540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RxyAA322_RS01550	COG0071	Belongs to the small heat shock protein (HSP20) family
RxyAA322_RS01555	COG0697	spore germination
RxyAA322_RS01565	COG0517	IMP dehydrogenase activity
RxyAA322_RS01570	COG0123	including yeast histone deacetylase and acetoin utilization protein
RxyAA322_RS01575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RxyAA322_RS01590	COG0784	Response regulator, receiver
RxyAA322_RS01590	COG3437	response regulator, receiver
RxyAA322_RS01595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RxyAA322_RS01640	COG1802	Transcriptional regulator
RxyAA322_RS01645	COG0179	Fumarylacetoacetate (FAA) hydrolase
RxyAA322_RS01650	COG0519	Catalyzes the synthesis of GMP from XMP
RxyAA322_RS01650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RxyAA322_RS01655	COG0174	glutamine synthetase
RxyAA322_RS01680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RxyAA322_RS01745	COG1846	Transcriptional regulator
RxyAA322_RS01745	COG0456	acetyltransferase
RxyAA322_RS01795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RxyAA322_RS01805	COG1979	alcohol dehydrogenase
RxyAA322_RS01825	COG0400	carboxylic ester hydrolase activity
RxyAA322_RS01830	COG0346	lactoylglutathione lyase activity
RxyAA322_RS01840	COG0346	lactoylglutathione lyase activity
RxyAA322_RS01850	COG1846	Transcriptional regulator
RxyAA322_RS01855	COG3706	GGDEF domain
RxyAA322_RS01865	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RxyAA322_RS01870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RxyAA322_RS01875	COG2376	Dihydroxyacetone kinase
RxyAA322_RS01880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RxyAA322_RS01895	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RxyAA322_RS01900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RxyAA322_RS01915	COG1253	flavin adenine dinucleotide binding
RxyAA322_RS01935	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RxyAA322_RS01950	COG1606	tRNA processing
RxyAA322_RS01960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RxyAA322_RS01970	COG0778	Nitroreductase
RxyAA322_RS01975	COG3424	synthase
RxyAA322_RS01980	COG1755	Isoprenylcysteine carboxyl methyltransferase
RxyAA322_RS01985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RxyAA322_RS01990	COG0442	prolyl-tRNA aminoacylation
RxyAA322_RS02000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RxyAA322_RS02005	COG0460	homoserine dehydrogenase
RxyAA322_RS02005	COG0527	aspartate kinase activity
RxyAA322_RS02010	COG0527	aspartate kinase activity
RxyAA322_RS02010	COG0460	homoserine dehydrogenase
RxyAA322_RS02015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RxyAA322_RS02040	COG0531	amino acid
RxyAA322_RS02050	COG1252	NADH dehydrogenase
RxyAA322_RS02055	COG0124	histidyl-tRNA synthetase
RxyAA322_RS02060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RxyAA322_RS02065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RxyAA322_RS02075	COG0131	Imidazoleglycerol-phosphate dehydratase
RxyAA322_RS02080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RxyAA322_RS02085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RxyAA322_RS02095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RxyAA322_RS02130	COG2267	carboxylic ester hydrolase activity
RxyAA322_RS02150	COG1131	(ABC) transporter
RxyAA322_RS02165	COG0521	Mo-molybdopterin cofactor biosynthetic process
RxyAA322_RS02170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS02175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RxyAA322_RS02180	COG0174	glutamine synthetase
RxyAA322_RS02190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RxyAA322_RS02225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RxyAA322_RS02245	COG0768	penicillin binding
RxyAA322_RS02250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RxyAA322_RS02255	COG0735	belongs to the Fur family
RxyAA322_RS02260	COG0803	Belongs to the bacterial solute-binding protein 9 family
RxyAA322_RS02265	COG1121	(ABC) transporter
RxyAA322_RS02270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RxyAA322_RS02280	COG0705	Rhomboid family
RxyAA322_RS02290	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RxyAA322_RS02310	COG0123	including yeast histone deacetylase and acetoin utilization protein
RxyAA322_RS02320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RxyAA322_RS02365	COG1191	sigma factor activity
RxyAA322_RS02370	COG1459	type II secretion system
RxyAA322_RS02380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RxyAA322_RS02390	COG2309	aminopeptidase activity
RxyAA322_RS02405	COG0302	gtp cyclohydrolase
RxyAA322_RS02415	COG3842	ATPase activity
RxyAA322_RS02425	COG1840	ABC-type Fe3 transport system, periplasmic component
RxyAA322_RS02430	COG2837	iron assimilation
RxyAA322_RS02435	COG2822	iron ion transport
RxyAA322_RS02440	COG0672	)-iron permease
RxyAA322_RS02445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RxyAA322_RS02465	COG0463	Glycosyl transferase, family 2
RxyAA322_RS02470	COG0473	3-isopropylmalate dehydrogenase activity
RxyAA322_RS02480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RxyAA322_RS02490	COG2226	methyltransferase
RxyAA322_RS02520	COG1764	response to oxidative stress
RxyAA322_RS02525	COG0633	Ferredoxin
RxyAA322_RS02530	COG4656	Part of a membrane complex involved in electron transport
RxyAA322_RS02575	COG2223	nitrite transmembrane transporter activity
RxyAA322_RS02585	COG1140	nitrate reductase beta subunit
RxyAA322_RS02590	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RxyAA322_RS02595	COG2181	nitrate reductase activity
RxyAA322_RS02600	COG4221	oxidoreductase activity
RxyAA322_RS02605	COG0668	transmembrane transport
RxyAA322_RS02610	COG0494	nUDIX hydrolase
RxyAA322_RS02615	COG1213	nucleotidyl transferase
RxyAA322_RS02615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RxyAA322_RS02635	COG0432	Pfam Uncharacterised protein family UPF0047
RxyAA322_RS02640	COG1115	amino acid carrier protein
RxyAA322_RS02650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RxyAA322_RS02660	COG0693	protein deglycase activity
RxyAA322_RS02685	COG0616	signal peptide processing
RxyAA322_RS02690	COG2223	nitrite transmembrane transporter activity
RxyAA322_RS02695	COG2409	Drug exporters of the RND superfamily
RxyAA322_RS02700	COG0735	belongs to the Fur family
RxyAA322_RS02705	COG1234	tRNA 3'-trailer cleavage
RxyAA322_RS02730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RxyAA322_RS02770	COG1968	undecaprenyl-diphosphatase activity
RxyAA322_RS02775	COG1605	Chorismate mutase
RxyAA322_RS02775	COG0077	Prephenate dehydratase
RxyAA322_RS02790	COG1278	Cold shock
RxyAA322_RS02795	COG0588	phosphoglycerate mutase activity
RxyAA322_RS02810	COG2720	vancomycin resistance protein
RxyAA322_RS02840	COG0697	spore germination
RxyAA322_RS02850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RxyAA322_RS02855	COG3387	PFAM Glycoside hydrolase 15-related
RxyAA322_RS02885	COG0405	Gamma-glutamyltransferase
RxyAA322_RS02905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RxyAA322_RS02910	COG0045	succinate-CoA ligase (ADP-forming) activity
RxyAA322_RS02935	COG1811	Na channel or pump
RxyAA322_RS02960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RxyAA322_RS02960	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RxyAA322_RS02970	COG0039	L-malate dehydrogenase activity
RxyAA322_RS02975	COG0778	Nitroreductase
RxyAA322_RS02980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS03015	COG0473	3-isopropylmalate dehydrogenase activity
RxyAA322_RS03020	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS03020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RxyAA322_RS03050	COG1598	PFAM Uncharacterised protein family UPF0150
RxyAA322_RS03055	COG0582	viral genome integration into host DNA
RxyAA322_RS03100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RxyAA322_RS03105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RxyAA322_RS03110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RxyAA322_RS03115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RxyAA322_RS03120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RxyAA322_RS03125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RxyAA322_RS03130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RxyAA322_RS03130	COG0072	phenylalanine-tRNA ligase activity
RxyAA322_RS03145	COG2094	Belongs to the DNA glycosylase MPG family
RxyAA322_RS03150	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RxyAA322_RS03155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RxyAA322_RS03185	COG0003	Pfam Anion-transporting ATPase
RxyAA322_RS03195	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
RxyAA322_RS03200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RxyAA322_RS03205	COG0217	transcriptional regulatory protein
RxyAA322_RS03210	COG2076	Multidrug Resistance protein
RxyAA322_RS03220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RxyAA322_RS03225	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RxyAA322_RS03230	COG0632	four-way junction helicase activity
RxyAA322_RS03235	COG2255	four-way junction helicase activity
RxyAA322_RS03245	COG0129	dihydroxy-acid dehydratase activity
RxyAA322_RS03250	COG2514	catechol 2,3-dioxygenase activity
RxyAA322_RS03260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RxyAA322_RS03265	COG0343	queuine tRNA-ribosyltransferase activity
RxyAA322_RS03275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RxyAA322_RS03285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RxyAA322_RS03290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RxyAA322_RS03300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RxyAA322_RS03305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RxyAA322_RS03310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS03315	COG0124	histidyl-tRNA synthetase
RxyAA322_RS03320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RxyAA322_RS03335	COG1053	succinate dehydrogenase
RxyAA322_RS03340	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RxyAA322_RS03345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RxyAA322_RS03360	COG0482	sulfurtransferase activity
RxyAA322_RS03360	COG0822	iron-sulfur transferase activity
RxyAA322_RS03385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RxyAA322_RS03390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RxyAA322_RS03395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RxyAA322_RS03400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RxyAA322_RS03405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RxyAA322_RS03410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RxyAA322_RS03410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RxyAA322_RS03420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RxyAA322_RS03420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RxyAA322_RS03430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RxyAA322_RS03435	COG1461	Dihydroxyacetone kinase
RxyAA322_RS03440	COG1307	EDD domain protein, DegV family
RxyAA322_RS03445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RxyAA322_RS03450	COG0742	ribosomal rna small subunit methyltransferase
RxyAA322_RS03455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RxyAA322_RS03470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RxyAA322_RS03475	COG0416	fatty acid biosynthetic process
RxyAA322_RS03480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RxyAA322_RS03485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RxyAA322_RS03490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RxyAA322_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS03500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RxyAA322_RS03505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RxyAA322_RS03510	COG0571	ribonuclease III activity
RxyAA322_RS03520	COG0552	protein localization to endoplasmic reticulum
RxyAA322_RS03530	COG0228	four-way junction DNA binding
RxyAA322_RS03535	COG1837	Belongs to the UPF0109 family
RxyAA322_RS03540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RxyAA322_RS03545	COG0336	Belongs to the RNA methyltransferase TrmD family
RxyAA322_RS03550	COG0335	large ribosomal subunit rRNA binding
RxyAA322_RS03555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RxyAA322_RS03560	COG0792	nuclease activity
RxyAA322_RS03570	COG0758	DNA mediated transformation
RxyAA322_RS03575	COG1191	sigma factor activity
RxyAA322_RS03580	COG0052	Belongs to the universal ribosomal protein uS2 family
RxyAA322_RS03585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RxyAA322_RS03590	COG0528	UMP kinase activity
RxyAA322_RS03595	COG0233	cytoplasmic translational termination
RxyAA322_RS03610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RxyAA322_RS03615	COG0750	zinc metalloprotease
RxyAA322_RS03620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RxyAA322_RS03625	COG1295	ribonuclease BN
RxyAA322_RS03630	COG0779	Required for maturation of 30S ribosomal subunits
RxyAA322_RS03635	COG0195	Participates in both transcription termination and antitermination
RxyAA322_RS03640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RxyAA322_RS03650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RxyAA322_RS03655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RxyAA322_RS03660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RxyAA322_RS03665	COG0196	riboflavin kinase activity
RxyAA322_RS03670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RxyAA322_RS03675	COG1185	polyribonucleotide nucleotidyltransferase activity
RxyAA322_RS03680	COG0612	Peptidase, M16
RxyAA322_RS03685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RxyAA322_RS03690	COG1674	ftsk spoiiie
RxyAA322_RS03700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RxyAA322_RS03705	COG2137	regulation of response to DNA damage stimulus
RxyAA322_RS03710	COG1418	mRNA catabolic process
RxyAA322_RS03720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RxyAA322_RS03725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RxyAA322_RS03730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RxyAA322_RS03740	COG4974	Belongs to the 'phage' integrase family
RxyAA322_RS03745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RxyAA322_RS03765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RxyAA322_RS03775	COG1160	GTP binding
RxyAA322_RS03785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RxyAA322_RS03790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RxyAA322_RS03795	COG1187	pseudouridine synthase activity
RxyAA322_RS03810	COG0686	Belongs to the AlaDH PNT family
RxyAA322_RS03825	COG0504	CTP synthase activity
RxyAA322_RS03850	COG0497	DNA recombination
RxyAA322_RS03855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RxyAA322_RS03865	COG0142	geranyltranstransferase activity
RxyAA322_RS03870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RxyAA322_RS03875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RxyAA322_RS03880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RxyAA322_RS03885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RxyAA322_RS03890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RxyAA322_RS03915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RxyAA322_RS03920	COG0242	peptide deformylase activity
RxyAA322_RS03925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RxyAA322_RS03930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RxyAA322_RS03940	COG1758	RNA polymerase activity
RxyAA322_RS03945	COG0194	GDP metabolic process
RxyAA322_RS03960	COG0543	2 iron, 2 sulfur cluster binding
RxyAA322_RS03965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RxyAA322_RS03970	COG0505	Belongs to the CarA family
RxyAA322_RS03975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RxyAA322_RS03980	COG0540	Belongs to the ATCase OTCase family
RxyAA322_RS03985	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RxyAA322_RS03990	COG0564	pseudouridine synthase activity
RxyAA322_RS03995	COG3599	regulation of cell shape
RxyAA322_RS04005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RxyAA322_RS04010	COG1799	cell septum assembly
RxyAA322_RS04015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RxyAA322_RS04020	COG1496	oxidoreductase activity
RxyAA322_RS04025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RxyAA322_RS04040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RxyAA322_RS04045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RxyAA322_RS04050	COG0772	Belongs to the SEDS family
RxyAA322_RS04055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RxyAA322_RS04060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RxyAA322_RS04065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RxyAA322_RS04070	COG0768	penicillin binding
RxyAA322_RS04080	COG0275	rRNA processing
RxyAA322_RS04085	COG2001	Belongs to the MraZ family
RxyAA322_RS04100	COG0358	DNA primase activity
RxyAA322_RS04105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RxyAA322_RS04110	COG1381	Involved in DNA repair and RecF pathway recombination
RxyAA322_RS04115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RxyAA322_RS04125	COG0295	cytidine deaminase activity
RxyAA322_RS04130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RxyAA322_RS04135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RxyAA322_RS04140	COG1480	7TM receptor with intracellular HD hydrolase
RxyAA322_RS04145	COG1702	phosphate starvation-inducible protein PhoH
RxyAA322_RS04150	COG1610	YqeY-like protein
RxyAA322_RS04155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RxyAA322_RS04160	COG0484	heat shock protein binding
RxyAA322_RS04170	COG0481	GTPase activity
RxyAA322_RS04175	COG0268	Binds directly to 16S ribosomal RNA
RxyAA322_RS04190	COG1555	photosystem II stabilization
RxyAA322_RS04190	COG1596	polysaccharide export
RxyAA322_RS04205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RxyAA322_RS04210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RxyAA322_RS04215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RxyAA322_RS04220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RxyAA322_RS04225	COG0772	Belongs to the SEDS family
RxyAA322_RS04240	COG1077	Cell shape determining protein MreB Mrl
RxyAA322_RS04245	COG2003	Belongs to the UPF0758 family
RxyAA322_RS04250	COG0424	maF-like protein
RxyAA322_RS04255	COG0105	UTP biosynthetic process
RxyAA322_RS04265	COG0285	dihydrofolate synthase activity
RxyAA322_RS04270	COG0525	valine-tRNA ligase activity
RxyAA322_RS04275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RxyAA322_RS04280	COG0740	serine-type endopeptidase activity
RxyAA322_RS04285	COG0544	peptidyl-prolyl cis-trans isomerase activity
RxyAA322_RS04295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RxyAA322_RS04295	COG4651	solute:proton antiporter activity
RxyAA322_RS04330	COG1131	(ABC) transporter
RxyAA322_RS04335	COG2197	response regulator
RxyAA322_RS04340	COG4585	Histidine kinase
RxyAA322_RS04350	COG2807	transmembrane transport
RxyAA322_RS04360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RxyAA322_RS04365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RxyAA322_RS04375	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RxyAA322_RS04380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RxyAA322_RS04390	COG5016	pyruvate
RxyAA322_RS04390	COG0511	ligase activity, forming carbon-carbon bonds
RxyAA322_RS04395	COG0439	Biotin carboxylase
RxyAA322_RS04400	COG0511	ligase activity, forming carbon-carbon bonds
RxyAA322_RS04425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RxyAA322_RS04430	COG3485	protocatechuate 3,4-dioxygenase
RxyAA322_RS04435	COG3485	protocatechuate 3,4-dioxygenase
RxyAA322_RS04445	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RxyAA322_RS04450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RxyAA322_RS04455	COG0583	DNA-binding transcription factor activity
RxyAA322_RS04460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RxyAA322_RS04465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RxyAA322_RS04470	COG1063	alcohol dehydrogenase
RxyAA322_RS04520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RxyAA322_RS04560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RxyAA322_RS04560	COG2226	methyltransferase
RxyAA322_RS04560	COG0596	Alpha beta hydrolase
RxyAA322_RS04580	COG0640	Transcriptional regulator
RxyAA322_RS04610	COG3872	metal-dependent enzyme
RxyAA322_RS04655	COG0640	Transcriptional regulator
RxyAA322_RS04675	COG1525	nuclease
RxyAA322_RS04700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RxyAA322_RS04710	COG0582	viral genome integration into host DNA
RxyAA322_RS04730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RxyAA322_RS04740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RxyAA322_RS04745	COG0557	exoribonuclease II activity
RxyAA322_RS04750	COG2177	Part of the ABC transporter FtsEX involved in
RxyAA322_RS04755	COG2884	Cell division ATP-binding protein ftsE
RxyAA322_RS04770	COG1393	Belongs to the ArsC family
RxyAA322_RS04775	COG2149	membrane
RxyAA322_RS04800	COG0583	DNA-binding transcription factor activity
RxyAA322_RS04820	COG2391	methyltransferase activity
RxyAA322_RS04825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS04835	COG0653	protein targeting
RxyAA322_RS04840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RxyAA322_RS04855	COG1007	ATP synthesis coupled electron transport
RxyAA322_RS04860	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RxyAA322_RS04865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RxyAA322_RS04870	COG0713	ATP synthesis coupled electron transport
RxyAA322_RS04880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RxyAA322_RS04885	COG0649	NAD binding
RxyAA322_RS04895	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RxyAA322_RS04900	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RxyAA322_RS04905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RxyAA322_RS04910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RxyAA322_RS04915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RxyAA322_RS04920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RxyAA322_RS04925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RxyAA322_RS04930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RxyAA322_RS04935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RxyAA322_RS04940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RxyAA322_RS04950	COG0356	it plays a direct role in the translocation of protons across the membrane
RxyAA322_RS04965	COG2131	deaminase
RxyAA322_RS04980	COG0009	L-threonylcarbamoyladenylate synthase
RxyAA322_RS04985	COG2890	protein-(glutamine-N5) methyltransferase activity
RxyAA322_RS04990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RxyAA322_RS04995	COG3872	metal-dependent enzyme
RxyAA322_RS05000	COG0254	rRNA binding
RxyAA322_RS05010	COG1494	fructose-1,6-bisphosphatase
RxyAA322_RS05015	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
RxyAA322_RS05025	COG0018	arginyl-trna synthetase
RxyAA322_RS05035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RxyAA322_RS05040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RxyAA322_RS05060	COG1595	DNA-templated transcription, initiation
RxyAA322_RS05080	COG1832	CoA-binding protein
RxyAA322_RS05095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RxyAA322_RS05100	COG0372	Belongs to the citrate synthase family
RxyAA322_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS05115	COG3347	Dehydrogenase
RxyAA322_RS05120	COG4952	isomerase
RxyAA322_RS05125	COG1879	ABC-type sugar transport system periplasmic component
RxyAA322_RS05130	COG1172	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS05135	COG1172	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS05140	COG1129	ABC transporter
RxyAA322_RS05145	COG1070	Carbohydrate kinase
RxyAA322_RS05160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RxyAA322_RS05170	COG1366	Belongs to the anti-sigma-factor antagonist family
RxyAA322_RS05175	COG1335	isochorismatase
RxyAA322_RS05180	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RxyAA322_RS05190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RxyAA322_RS05195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RxyAA322_RS05210	COG4770	biotin carboxylase activity
RxyAA322_RS05215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RxyAA322_RS05220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RxyAA322_RS05245	COG1960	acyl-CoA dehydrogenase activity
RxyAA322_RS05260	COG1595	DNA-templated transcription, initiation
RxyAA322_RS05265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RxyAA322_RS05275	COG1597	lipid kinase activity
RxyAA322_RS05280	COG2084	Dehydrogenase
RxyAA322_RS05290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RxyAA322_RS05295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RxyAA322_RS05305	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS05310	COG3718	enzyme involved in inositol metabolism
RxyAA322_RS05315	COG3962	Belongs to the TPP enzyme family
RxyAA322_RS05335	COG1082	Xylose isomerase domain protein TIM barrel
RxyAA322_RS05340	COG0673	inositol 2-dehydrogenase activity
RxyAA322_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS05370	COG0673	inositol 2-dehydrogenase activity
RxyAA322_RS05375	COG2188	Transcriptional regulator
RxyAA322_RS05400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RxyAA322_RS05415	COG0183	Belongs to the thiolase family
RxyAA322_RS05420	COG0318	PFAM AMP-dependent synthetase and ligase
RxyAA322_RS05425	COG2986	histidine ammonia-lyase
RxyAA322_RS05450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RxyAA322_RS05455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS05465	COG1309	transcriptional regulator
RxyAA322_RS05470	COG1024	Enoyl-CoA hydratase
RxyAA322_RS05475	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS05525	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS05530	COG1250	3-hydroxyacyl-CoA dehydrogenase
RxyAA322_RS05535	COG1024	Enoyl-CoA hydratase
RxyAA322_RS05550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RxyAA322_RS05590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RxyAA322_RS05605	COG1573	uracil-dna glycosylase
RxyAA322_RS05630	COG0371	Dehydrogenase
RxyAA322_RS05650	COG1960	acyl-CoA dehydrogenase activity
RxyAA322_RS05660	COG0318	PFAM AMP-dependent synthetase and ligase
RxyAA322_RS05685	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS05700	COG1024	Enoyl-CoA hydratase
RxyAA322_RS05715	COG3328	transposase activity
RxyAA322_RS05720	COG3328	transposase activity
RxyAA322_RS05765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RxyAA322_RS05785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RxyAA322_RS05835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RxyAA322_RS05845	COG3311	Transcriptional regulator
RxyAA322_RS05865	COG1895	HEPN domain
RxyAA322_RS05895	COG0582	viral genome integration into host DNA
RxyAA322_RS05915	COG1067	ATP-dependent peptidase activity
RxyAA322_RS05930	COG0726	polysaccharide deacetylase
RxyAA322_RS05955	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS05985	COG0489	protein tyrosine kinase activity
RxyAA322_RS05990	COG3944	biosynthesis protein
RxyAA322_RS06025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RxyAA322_RS06035	COG2197	response regulator
RxyAA322_RS06060	COG1063	alcohol dehydrogenase
RxyAA322_RS06065	COG3191	aminopeptidase activity
RxyAA322_RS06080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RxyAA322_RS06085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RxyAA322_RS06090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RxyAA322_RS06100	COG0109	protoheme IX farnesyltransferase activity
RxyAA322_RS06105	COG1575	Belongs to the MenA family. Type 1 subfamily
RxyAA322_RS06110	COG0805	protein transport
RxyAA322_RS06115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RxyAA322_RS06125	COG0402	S-adenosylhomocysteine deaminase activity
RxyAA322_RS06135	COG2226	methyltransferase
RxyAA322_RS06145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RxyAA322_RS06150	COG0113	porphobilinogen synthase activity
RxyAA322_RS06160	COG0181	hydroxymethylbilane synthase activity
RxyAA322_RS06165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RxyAA322_RS06170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RxyAA322_RS06170	COG1648	precorrin-2 dehydrogenase activity
RxyAA322_RS06175	COG0315	cyclic pyranopterin monophosphate synthase activity
RxyAA322_RS06205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RxyAA322_RS06225	COG1653	transport
RxyAA322_RS06230	COG3842	ATPase activity
RxyAA322_RS06260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RxyAA322_RS06265	COG0584	glycerophosphoryl diester phosphodiesterase
RxyAA322_RS06290	COG0149	triose-phosphate isomerase activity
RxyAA322_RS06295	COG0126	phosphoglycerate kinase activity
RxyAA322_RS06300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RxyAA322_RS06305	COG1481	regulation of sporulation
RxyAA322_RS06310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RxyAA322_RS06315	COG0435	Glutathione S-transferase
RxyAA322_RS06320	COG1660	Displays ATPase and GTPase activities
RxyAA322_RS06325	COG0322	excinuclease ABC activity
RxyAA322_RS06340	COG0531	amino acid
RxyAA322_RS06355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RxyAA322_RS06360	COG3835	regulator
RxyAA322_RS06365	COG0004	ammonium transporteR
RxyAA322_RS06375	COG0556	nucleotide-excision repair
RxyAA322_RS06385	COG0237	dephospho-CoA kinase activity
RxyAA322_RS06390	COG0539	negative regulation of cytoplasmic translation
RxyAA322_RS06400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RxyAA322_RS06415	COG0582	viral genome integration into host DNA
RxyAA322_RS06440	COG1132	(ABC) transporter
RxyAA322_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS06495	COG0604	alcohol dehydrogenase
RxyAA322_RS06495	COG3321	synthase
RxyAA322_RS06505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RxyAA322_RS06535	COG2197	response regulator
RxyAA322_RS06540	COG2205	protein histidine kinase activity
RxyAA322_RS06545	COG0745	RESPONSE REGULATOR receiver
RxyAA322_RS06565	COG1525	nuclease
RxyAA322_RS06630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RxyAA322_RS06640	COG2154	pterin-4-alpha-carbinolamine dehydratase
RxyAA322_RS06645	COG1525	nuclease
RxyAA322_RS06650	COG0693	protein deglycase activity
RxyAA322_RS06655	COG2723	6-phospho-beta-galactosidase activity
RxyAA322_RS06660	COG0667	Aldo Keto reductase
RxyAA322_RS06670	COG0318	PFAM AMP-dependent synthetase and ligase
RxyAA322_RS06695	COG0183	Belongs to the thiolase family
RxyAA322_RS06700	COG1024	Enoyl-CoA hydratase
RxyAA322_RS06700	COG1250	3-hydroxyacyl-CoA dehydrogenase
RxyAA322_RS06710	COG1695	Transcriptional regulator
RxyAA322_RS06720	COG1960	acyl-CoA dehydrogenase activity
RxyAA322_RS06735	COG0604	alcohol dehydrogenase
RxyAA322_RS06740	COG2224	Isocitrate lyase
RxyAA322_RS06745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RxyAA322_RS06755	COG0583	DNA-binding transcription factor activity
RxyAA322_RS06760	COG2755	lipolytic protein G-D-S-L family
RxyAA322_RS06760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RxyAA322_RS06770	COG0473	3-isopropylmalate dehydrogenase activity
RxyAA322_RS06790	COG3001	Fructosamine kinase
RxyAA322_RS06795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RxyAA322_RS06810	COG1115	amino acid carrier protein
RxyAA322_RS06830	COG0825	malonyl-CoA metabolic process
RxyAA322_RS06835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RxyAA322_RS06840	COG0159	tryptophan synthase activity
RxyAA322_RS06845	COG0133	tryptophan synthase activity
RxyAA322_RS06850	COG0135	phosphoribosylanthranilate isomerase activity
RxyAA322_RS06860	COG2200	EAL domain
RxyAA322_RS06860	COG2199	diguanylate cyclase activity
RxyAA322_RS06860	COG2202	Pas domain
RxyAA322_RS06865	COG0134	indole-3-glycerol-phosphate synthase activity
RxyAA322_RS06870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RxyAA322_RS06885	COG2223	nitrite transmembrane transporter activity
RxyAA322_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS06900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RxyAA322_RS06945	COG1063	alcohol dehydrogenase
RxyAA322_RS06955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RxyAA322_RS06965	COG0655	NAD(P)H dehydrogenase (quinone) activity
RxyAA322_RS06970	COG1309	transcriptional regulator
RxyAA322_RS06980	COG0140	phosphoribosyl-ATP diphosphatase activity
RxyAA322_RS06980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RxyAA322_RS06985	COG0107	imidazoleglycerol-phosphate synthase activity
RxyAA322_RS06995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RxyAA322_RS07000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RxyAA322_RS07005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RxyAA322_RS07010	COG4122	O-methyltransferase activity
RxyAA322_RS07015	COG0101	tRNA pseudouridine synthase activity
RxyAA322_RS07020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RxyAA322_RS07025	COG1122	ATPase activity
RxyAA322_RS07030	COG1122	ATPase activity
RxyAA322_RS07035	COG0203	ribosomal protein L17
RxyAA322_RS07040	COG0202	RNA polymerase activity
RxyAA322_RS07045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RxyAA322_RS07050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RxyAA322_RS07055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RxyAA322_RS07060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RxyAA322_RS07065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RxyAA322_RS07070	COG0024	Methionine aminopeptidase
RxyAA322_RS07075	COG0563	adenylate kinase activity
RxyAA322_RS07085	COG0200	Binds to the 23S rRNA
RxyAA322_RS07090	COG1841	ribosomal large subunit assembly
RxyAA322_RS07095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RxyAA322_RS07100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RxyAA322_RS07105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RxyAA322_RS07110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RxyAA322_RS07115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RxyAA322_RS07120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RxyAA322_RS07125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RxyAA322_RS07130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RxyAA322_RS07135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RxyAA322_RS07140	COG0255	Belongs to the universal ribosomal protein uL29 family
RxyAA322_RS07145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RxyAA322_RS07150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RxyAA322_RS07155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RxyAA322_RS07160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RxyAA322_RS07165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RxyAA322_RS07170	COG0089	rRNA binding
RxyAA322_RS07175	COG0088	Forms part of the polypeptide exit tunnel
RxyAA322_RS07180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RxyAA322_RS07185	COG0051	transcription antitermination factor activity, RNA binding
RxyAA322_RS07190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RxyAA322_RS07195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RxyAA322_RS07200	COG0049	tRNA binding
RxyAA322_RS07205	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RxyAA322_RS07210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RxyAA322_RS07215	COG0085	RNA polymerase activity
RxyAA322_RS07220	COG0222	ribosome binding
RxyAA322_RS07225	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RxyAA322_RS07230	COG0081	regulation of translation
RxyAA322_RS07235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RxyAA322_RS07240	COG0250	Participates in transcription elongation, termination and antitermination
RxyAA322_RS07255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RxyAA322_RS07260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RxyAA322_RS07290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RxyAA322_RS07295	COG0215	cysteine-tRNA ligase activity
RxyAA322_RS07300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RxyAA322_RS07305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RxyAA322_RS07310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RxyAA322_RS07315	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RxyAA322_RS07320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RxyAA322_RS07330	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
RxyAA322_RS07335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RxyAA322_RS07340	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RxyAA322_RS07350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RxyAA322_RS07355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RxyAA322_RS07365	COG0037	tRNA processing
RxyAA322_RS07410	COG0012	GTP binding
RxyAA322_RS07415	COG0822	iron-sulfur transferase activity
RxyAA322_RS07420	COG0346	lactoylglutathione lyase activity
RxyAA322_RS07470	COG1233	COG1233 Phytoene dehydrogenase and related
RxyAA322_RS07475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RxyAA322_RS07485	COG0477	Major facilitator Superfamily
RxyAA322_RS07490	COG0745	RESPONSE REGULATOR receiver
RxyAA322_RS07495	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RxyAA322_RS07510	COG1611	Belongs to the LOG family
RxyAA322_RS07545	COG1490	D-aminoacyl-tRNA deacylase activity
RxyAA322_RS07555	COG0488	(ABC) transporter
RxyAA322_RS07565	COG0860	N-Acetylmuramoyl-L-alanine amidase
RxyAA322_RS07570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RxyAA322_RS07575	COG3118	belongs to the thioredoxin family
RxyAA322_RS07580	COG1105	Belongs to the carbohydrate kinase PfkB family
RxyAA322_RS07585	COG1686	Belongs to the peptidase S11 family
RxyAA322_RS07595	COG0284	orotidine-5'-phosphate decarboxylase activity
RxyAA322_RS07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RxyAA322_RS07625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RxyAA322_RS07635	COG0483	inositol monophosphate 1-phosphatase activity
RxyAA322_RS07640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RxyAA322_RS07650	COG0546	phosphoglycolate phosphatase activity
RxyAA322_RS07655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RxyAA322_RS07660	COG1215	transferase activity, transferring glycosyl groups
RxyAA322_RS07675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RxyAA322_RS07680	COG2738	Putative neutral zinc metallopeptidase
RxyAA322_RS07685	COG0071	Belongs to the small heat shock protein (HSP20) family
RxyAA322_RS07695	COG0706	membrane insertase activity
RxyAA322_RS07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
RxyAA322_RS07705	COG0022	dehydrogenase e1 component
RxyAA322_RS07710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RxyAA322_RS07715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RxyAA322_RS07725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RxyAA322_RS07730	COG1181	Belongs to the D-alanine--D-alanine ligase family
RxyAA322_RS07735	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RxyAA322_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS07770	COG1250	3-hydroxyacyl-CoA dehydrogenase
RxyAA322_RS07780	COG2045	Belongs to the ComB family
RxyAA322_RS07790	COG1024	Enoyl-CoA hydratase
RxyAA322_RS07800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RxyAA322_RS07805	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS07830	COG0730	response to heat
RxyAA322_RS07835	COG2897	thiosulfate sulfurtransferase activity
RxyAA322_RS07850	COG0529	Catalyzes the synthesis of activated sulfate
RxyAA322_RS07860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RxyAA322_RS07865	COG0318	PFAM AMP-dependent synthetase and ligase
RxyAA322_RS07875	COG0183	Belongs to the thiolase family
RxyAA322_RS07890	COG1595	DNA-templated transcription, initiation
RxyAA322_RS07905	COG1024	Enoyl-CoA hydratase
RxyAA322_RS07910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RxyAA322_RS07910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RxyAA322_RS07925	COG0259	pyridoxamine-phosphate oxidase activity
RxyAA322_RS07930	COG4129	membrane
RxyAA322_RS07935	COG0247	lactate metabolic process
RxyAA322_RS07935	COG0277	FAD linked oxidase domain protein
RxyAA322_RS07940	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RxyAA322_RS07955	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS07960	COG1454	alcohol dehydrogenase
RxyAA322_RS07965	COG0318	PFAM AMP-dependent synthetase and ligase
RxyAA322_RS07975	COG3243	poly(R)-hydroxyalkanoic acid synthase
RxyAA322_RS07980	COG3243	poly(R)-hydroxyalkanoic acid synthase
RxyAA322_RS07985	COG1960	acyl-CoA dehydrogenase activity
RxyAA322_RS07995	COG0183	Belongs to the thiolase family
RxyAA322_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS08025	COG0352	thiamine-phosphate diphosphorylase activity
RxyAA322_RS08030	COG2022	thiamine diphosphate biosynthetic process
RxyAA322_RS08045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RxyAA322_RS08050	COG0372	Belongs to the citrate synthase family
RxyAA322_RS08055	COG2079	MmgE PrpD family protein
RxyAA322_RS08060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RxyAA322_RS08065	COG0022	dehydrogenase e1 component
RxyAA322_RS08075	COG3199	ATP-NAD kinase
RxyAA322_RS08090	COG2814	Major facilitator Superfamily
RxyAA322_RS08095	COG4336	lyase activity
RxyAA322_RS08145	COG0477	Major facilitator Superfamily
RxyAA322_RS08150	COG2186	Transcriptional regulator
RxyAA322_RS08155	COG1960	acyl-CoA dehydrogenase activity
RxyAA322_RS08170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RxyAA322_RS08175	COG0601	transmembrane transport
RxyAA322_RS08180	COG0747	negative chemotaxis
RxyAA322_RS08195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RxyAA322_RS08220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RxyAA322_RS08225	COG0561	phosphatase activity
RxyAA322_RS08235	COG3546	catalase activity
RxyAA322_RS08240	COG1414	Transcriptional regulator
RxyAA322_RS08245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RxyAA322_RS08305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RxyAA322_RS08350	COG1250	3-hydroxyacyl-CoA dehydrogenase
RxyAA322_RS08350	COG1024	Enoyl-CoA hydratase
RxyAA322_RS08355	COG0183	Belongs to the thiolase family
RxyAA322_RS08365	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS08370	COG0300	oxidoreductase activity
RxyAA322_RS08395	COG0589	response to stress
RxyAA322_RS08400	COG2197	response regulator
RxyAA322_RS08405	COG1294	oxidase, subunit
RxyAA322_RS08410	COG1271	oxidase subunit
RxyAA322_RS08415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RxyAA322_RS08420	COG4988	ABC transporter
RxyAA322_RS08480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RxyAA322_RS08490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RxyAA322_RS08495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RxyAA322_RS08505	COG1122	ATPase activity
RxyAA322_RS08510	COG1122	ATPase activity
RxyAA322_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS08525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RxyAA322_RS08535	COG0028	Belongs to the TPP enzyme family
RxyAA322_RS08540	COG0508	dehydrogenase complex catalyzes the overall conversion of
RxyAA322_RS08545	COG0022	dehydrogenase e1 component
RxyAA322_RS08550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RxyAA322_RS08555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RxyAA322_RS08555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RxyAA322_RS08560	COG1960	acyl-CoA dehydrogenase activity
RxyAA322_RS08575	COG1203	CRISPR-associated helicase, Cas3
RxyAA322_RS08605	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RxyAA322_RS08620	COG2902	Dehydrogenase
RxyAA322_RS08625	COG0183	Belongs to the thiolase family
RxyAA322_RS08630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RxyAA322_RS08640	COG1703	isobutyryl-CoA mutase activity
RxyAA322_RS08645	COG0508	dehydrogenase complex catalyzes the overall conversion of
RxyAA322_RS08650	COG0567	Dehydrogenase, E1 component
RxyAA322_RS08655	COG0626	cystathionine gamma-synthase activity
RxyAA322_RS08665	COG1331	Highly conserved protein containing a thioredoxin domain
RxyAA322_RS08675	COG3588	fructose-bisphosphate aldolase
RxyAA322_RS08705	COG0321	lipoyl(octanoyl) transferase activity
RxyAA322_RS08710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RxyAA322_RS08715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RxyAA322_RS08720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RxyAA322_RS08735	COG0314	molybdopterin synthase activity
RxyAA322_RS08755	COG0372	Belongs to the citrate synthase family
RxyAA322_RS08760	COG1546	Belongs to the CinA family
RxyAA322_RS08760	COG1058	Belongs to the CinA family
RxyAA322_RS08765	COG1713	HD superfamily hydrolase involved in NAD metabolism
RxyAA322_RS08770	COG1988	membrane-bound metal-dependent
RxyAA322_RS08790	COG2079	MmgE PrpD family protein
RxyAA322_RS08830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RxyAA322_RS08835	COG2226	methyltransferase
RxyAA322_RS08840	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS08845	COG0720	synthase
RxyAA322_RS08855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RxyAA322_RS08855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RxyAA322_RS08860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RxyAA322_RS08900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RxyAA322_RS08905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RxyAA322_RS08915	COG3537	Alpha-1,2-mannosidase
RxyAA322_RS08920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RxyAA322_RS08925	COG3537	Alpha-1,2-mannosidase
RxyAA322_RS08930	COG1609	Transcriptional regulator
RxyAA322_RS08950	COG0728	peptidoglycan biosynthetic process
RxyAA322_RS08970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RxyAA322_RS08970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RxyAA322_RS08980	COG0589	response to stress
RxyAA322_RS08995	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS09005	COG0756	dUTP diphosphatase activity
RxyAA322_RS09020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RxyAA322_RS09035	COG2197	response regulator
RxyAA322_RS09040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RxyAA322_RS09055	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
RxyAA322_RS09060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RxyAA322_RS09090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RxyAA322_RS09105	COG0725	ABC transporter, periplasmic molybdate-binding protein
RxyAA322_RS09120	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RxyAA322_RS09125	COG2860	membrane
RxyAA322_RS09130	COG4977	sequence-specific DNA binding
RxyAA322_RS09160	COG0667	Aldo Keto reductase
RxyAA322_RS09170	COG1131	(ABC) transporter
RxyAA322_RS09175	COG0842	Transport permease protein
RxyAA322_RS09185	COG4297	protein containing double-stranded beta helix domain
RxyAA322_RS09240	COG2172	sigma factor antagonist activity
RxyAA322_RS09245	COG1366	Belongs to the anti-sigma-factor antagonist family
RxyAA322_RS09260	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS09275	COG1366	Belongs to the anti-sigma-factor antagonist family
RxyAA322_RS09285	COG0745	RESPONSE REGULATOR receiver
RxyAA322_RS09300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RxyAA322_RS09305	COG0166	Belongs to the GPI family
RxyAA322_RS09310	COG0530	calcium, potassium:sodium antiporter activity
RxyAA322_RS09325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RxyAA322_RS09345	COG3119	arylsulfatase activity
RxyAA322_RS09350	COG1695	Transcriptional regulator
RxyAA322_RS09365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RxyAA322_RS09380	COG3551	Protein conserved in bacteria
RxyAA322_RS09435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RxyAA322_RS09440	COG0723	plastoquinol--plastocyanin reductase activity
RxyAA322_RS09455	COG2271	Major facilitator Superfamily
RxyAA322_RS09460	COG0589	response to stress
RxyAA322_RS09470	COG0028	Belongs to the TPP enzyme family
RxyAA322_RS09475	COG4948	Mandelate Racemase Muconate Lactonizing
RxyAA322_RS09480	COG0247	lactate metabolic process
RxyAA322_RS09480	COG0277	FAD linked oxidase domain protein
RxyAA322_RS09495	COG3383	formate dehydrogenase (NAD+) activity
RxyAA322_RS09495	COG0243	molybdopterin cofactor binding
RxyAA322_RS09500	COG3383	formate dehydrogenase (NAD+) activity
RxyAA322_RS09500	COG0243	molybdopterin cofactor binding
RxyAA322_RS09505	COG0437	4 iron, 4 sulfur cluster binding
RxyAA322_RS09520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RxyAA322_RS09525	COG1960	acyl-CoA dehydrogenase activity
RxyAA322_RS09530	COG0252	asparaginase activity
RxyAA322_RS09545	COG0523	cobalamin synthesis protein
RxyAA322_RS09560	COG1335	isochorismatase
RxyAA322_RS09570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RxyAA322_RS09575	COG0628	permease
RxyAA322_RS09580	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS09595	COG3387	PFAM Glycoside hydrolase 15-related
RxyAA322_RS09605	COG0667	Aldo Keto reductase
RxyAA322_RS09625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RxyAA322_RS09625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RxyAA322_RS09650	COG1132	(ABC) transporter
RxyAA322_RS09655	COG0494	nUDIX hydrolase
RxyAA322_RS09660	COG0316	Belongs to the HesB IscA family
RxyAA322_RS09675	COG0714	Associated with various cellular activities
RxyAA322_RS09690	COG1528	Iron-storage protein
RxyAA322_RS09700	COG4948	Mandelate Racemase Muconate Lactonizing
RxyAA322_RS09705	COG0745	RESPONSE REGULATOR receiver
RxyAA322_RS09715	COG5001	Diguanylate cyclase
RxyAA322_RS09720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RxyAA322_RS09725	COG4572	Cation transport regulator
RxyAA322_RS09730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RxyAA322_RS09740	COG0352	thiamine-phosphate diphosphorylase activity
RxyAA322_RS09750	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RxyAA322_RS09755	COG0351	phosphomethylpyrimidine kinase
RxyAA322_RS09755	COG0352	thiamine-phosphate diphosphorylase activity
RxyAA322_RS09780	COG2814	Major facilitator Superfamily
RxyAA322_RS09795	COG2897	thiosulfate sulfurtransferase activity
RxyAA322_RS09805	COG1366	Belongs to the anti-sigma-factor antagonist family
RxyAA322_RS09820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RxyAA322_RS09825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RxyAA322_RS09830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RxyAA322_RS09840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RxyAA322_RS09865	COG1435	thymidine kinase activity
RxyAA322_RS09870	COG0398	Pfam SNARE associated Golgi protein
RxyAA322_RS09875	COG2301	Belongs to the HpcH HpaI aldolase family
RxyAA322_RS09895	COG4152	abc transporter atp-binding protein
RxyAA322_RS09900	COG1668	transmembrane transport
RxyAA322_RS09905	COG0247	lactate metabolic process
RxyAA322_RS09910	COG0277	FAD linked oxidase domain protein
RxyAA322_RS09915	COG0277	FAD linked oxidase domain protein
RxyAA322_RS09920	COG1953	Uracil, thiamine, allantoin
RxyAA322_RS09945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RxyAA322_RS09975	COG2351	hydroxyisourate hydrolase activity
RxyAA322_RS09980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RxyAA322_RS09990	COG0540	Belongs to the ATCase OTCase family
RxyAA322_RS09995	COG0549	Belongs to the carbamate kinase family
RxyAA322_RS10000	COG0252	asparaginase activity
RxyAA322_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS10015	COG3622	Belongs to the hyi family
RxyAA322_RS10020	COG2084	Dehydrogenase
RxyAA322_RS10025	COG3960	tartronate-semialdehyde synthase activity
RxyAA322_RS10030	COG2379	hydroxypyruvate reductase
RxyAA322_RS10035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RxyAA322_RS10080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RxyAA322_RS10090	COG0114	fumarate hydratase activity
RxyAA322_RS10130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RxyAA322_RS10140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RxyAA322_RS10155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RxyAA322_RS10165	COG2226	methyltransferase
RxyAA322_RS10170	COG1914	H( )-stimulated, divalent metal cation uptake system
RxyAA322_RS10175	COG0137	argininosuccinate synthase activity
RxyAA322_RS10185	COG1438	arginine binding
RxyAA322_RS10190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RxyAA322_RS10195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RxyAA322_RS10200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RxyAA322_RS10205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RxyAA322_RS10210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RxyAA322_RS10220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RxyAA322_RS10225	COG0318	PFAM AMP-dependent synthetase and ligase
RxyAA322_RS10240	COG2267	carboxylic ester hydrolase activity
RxyAA322_RS10245	COG3548	integral membrane protein
RxyAA322_RS10250	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RxyAA322_RS10255	COG1169	isochorismate synthase
RxyAA322_RS10275	COG1268	BioY protein
RxyAA322_RS10290	COG0833	amino acid
RxyAA322_RS10295	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS10300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RxyAA322_RS10310	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RxyAA322_RS10320	COG3835	regulator
RxyAA322_RS10330	COG0789	Transcriptional regulator
RxyAA322_RS10340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RxyAA322_RS10345	COG3842	ATPase activity
RxyAA322_RS10350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RxyAA322_RS10360	COG1177	transmembrane transport
RxyAA322_RS10365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS10400	COG3321	synthase
RxyAA322_RS10400	COG0604	alcohol dehydrogenase
RxyAA322_RS10405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RxyAA322_RS10410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RxyAA322_RS10415	COG1363	Peptidase, m42
RxyAA322_RS10435	COG0730	response to heat
RxyAA322_RS10450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RxyAA322_RS10455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RxyAA322_RS10470	COG3181	Tripartite tricarboxylate transporter family receptor
RxyAA322_RS10475	COG1802	Transcriptional regulator
RxyAA322_RS10480	COG0625	glutathione transferase activity
RxyAA322_RS10485	COG0154	amidase activity
RxyAA322_RS10490	COG2031	fatty acid transporter
RxyAA322_RS10495	COG0825	malonyl-CoA metabolic process
RxyAA322_RS10495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RxyAA322_RS10500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RxyAA322_RS10515	COG1802	Transcriptional regulator
RxyAA322_RS10520	COG0586	Pfam SNARE associated Golgi protein
RxyAA322_RS10525	COG0671	phosphoesterase, PA-phosphatase related
RxyAA322_RS10530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RxyAA322_RS10530	COG1796	DNA polymerase
RxyAA322_RS10540	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RxyAA322_RS10555	COG1122	ATPase activity
RxyAA322_RS10565	COG1953	Uracil, thiamine, allantoin
RxyAA322_RS10575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RxyAA322_RS10590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RxyAA322_RS10610	COG1653	transport
RxyAA322_RS10635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RxyAA322_RS10640	COG1802	Transcriptional regulator
RxyAA322_RS10645	COG0604	alcohol dehydrogenase
RxyAA322_RS10650	COG0402	S-adenosylhomocysteine deaminase activity
RxyAA322_RS10660	COG0179	Fumarylacetoacetate (FAA) hydrolase
RxyAA322_RS10675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RxyAA322_RS10680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RxyAA322_RS10720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RxyAA322_RS10735	COG0697	spore germination
RxyAA322_RS10740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RxyAA322_RS10750	COG2815	serine threonine protein kinase
RxyAA322_RS10750	COG0515	serine threonine protein kinase
RxyAA322_RS10755	COG4214	carbohydrate transport
RxyAA322_RS10765	COG4213	ABC transporter substrate-binding protein
RxyAA322_RS10770	COG1940	carbohydrate kinase activity
RxyAA322_RS10785	COG1473	amidohydrolase
RxyAA322_RS10805	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
RxyAA322_RS10810	COG1278	Cold shock
RxyAA322_RS10815	COG0546	phosphoglycolate phosphatase activity
RxyAA322_RS10820	COG0354	folic acid binding
RxyAA322_RS10830	COG0396	ATPase activity
RxyAA322_RS10835	COG0719	Fe-S assembly protein
RxyAA322_RS10845	COG0719	Fe-S assembly protein
RxyAA322_RS10855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RxyAA322_RS10860	COG0822	iron-sulfur transferase activity
RxyAA322_RS10890	COG4585	Histidine kinase
RxyAA322_RS10895	COG1079	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS10900	COG4603	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS10905	COG3845	ABC transporter
RxyAA322_RS10910	COG1744	ABC transporter substrate-binding protein PnrA-like
RxyAA322_RS10920	COG1316	TRANSCRIPTIONal
RxyAA322_RS10930	COG0471	metal ion transport
RxyAA322_RS10950	COG0243	molybdopterin cofactor binding
RxyAA322_RS10955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RxyAA322_RS10965	COG3162	membrane
RxyAA322_RS10970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RxyAA322_RS10975	COG1764	response to oxidative stress
RxyAA322_RS10980	COG1335	isochorismatase
RxyAA322_RS10985	COG3540	Alkaline phosphatase
RxyAA322_RS11020	COG2217	Heavy metal translocating P-type atpase
RxyAA322_RS11025	COG1937	Protein conserved in bacteria
RxyAA322_RS11040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RxyAA322_RS11045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RxyAA322_RS11060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RxyAA322_RS11070	COG0713	ATP synthesis coupled electron transport
RxyAA322_RS11075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RxyAA322_RS11085	COG1007	ATP synthesis coupled electron transport
RxyAA322_RS11090	COG1054	Belongs to the UPF0176 family
RxyAA322_RS11100	COG2132	Multicopper oxidase
RxyAA322_RS11105	COG2226	methyltransferase
RxyAA322_RS11160	COG1104	cysteine desulfurase activity
RxyAA322_RS11180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RxyAA322_RS11185	COG0589	response to stress
RxyAA322_RS11190	COG4251	negative regulation of phosphorylation
RxyAA322_RS11215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RxyAA322_RS11220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RxyAA322_RS11230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RxyAA322_RS11240	COG4585	Histidine kinase
RxyAA322_RS11245	COG0784	Response regulator, receiver
RxyAA322_RS11260	COG1131	(ABC) transporter
RxyAA322_RS11280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RxyAA322_RS11285	COG3118	belongs to the thioredoxin family
RxyAA322_RS11305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS11315	COG2720	vancomycin resistance protein
RxyAA322_RS11330	COG1609	Transcriptional regulator
RxyAA322_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS11340	COG0800	Aldolase
RxyAA322_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS11355	COG0477	Major facilitator Superfamily
RxyAA322_RS11360	COG0019	diaminopimelate decarboxylase activity
RxyAA322_RS11365	COG0436	Aminotransferase
RxyAA322_RS11495	COG2197	response regulator
RxyAA322_RS11500	COG2205	protein histidine kinase activity
RxyAA322_RS11510	COG0383	alpha-mannosidase activity
RxyAA322_RS11515	COG2182	Extracellular solute-binding protein
RxyAA322_RS11520	COG1175	transmembrane transport
RxyAA322_RS11525	COG0395	ABC-type sugar transport system, permease component
RxyAA322_RS11530	COG1653	transport
RxyAA322_RS11535	COG0628	permease
RxyAA322_RS11540	COG1131	(ABC) transporter
RxyAA322_RS11555	COG0598	Magnesium transport protein CorA
RxyAA322_RS11565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RxyAA322_RS11570	COG0363	glucosamine-6-phosphate deaminase activity
RxyAA322_RS11580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RxyAA322_RS11585	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RxyAA322_RS11590	COG3959	Transketolase, thiamine diphosphate binding domain
RxyAA322_RS11595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RxyAA322_RS11600	COG0789	Transcriptional regulator
RxyAA322_RS11610	COG0629	single-stranded DNA binding
RxyAA322_RS11615	COG2333	competence protein COMEC
RxyAA322_RS11615	COG0658	competence protein
RxyAA322_RS11620	COG2217	Heavy metal translocating P-type atpase
RxyAA322_RS11630	COG3118	belongs to the thioredoxin family
RxyAA322_RS11665	COG3119	arylsulfatase activity
RxyAA322_RS11680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RxyAA322_RS11690	COG2308	Evidence 4 Homologs of previously reported genes of
RxyAA322_RS11705	COG0439	Biotin carboxylase
RxyAA322_RS11710	COG0511	ligase activity, forming carbon-carbon bonds
RxyAA322_RS11715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RxyAA322_RS11720	COG2267	carboxylic ester hydrolase activity
RxyAA322_RS11730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RxyAA322_RS11735	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RxyAA322_RS11755	COG2815	serine threonine protein kinase
RxyAA322_RS11755	COG0515	serine threonine protein kinase
RxyAA322_RS11760	COG5001	Diguanylate cyclase
RxyAA322_RS11760	COG1716	ATPase activity
RxyAA322_RS11765	COG1716	ATPase activity
RxyAA322_RS11770	COG0631	protein serine/threonine phosphatase activity
RxyAA322_RS11780	COG0768	penicillin binding
RxyAA322_RS11785	COG0515	serine threonine protein kinase
RxyAA322_RS11785	COG2815	serine threonine protein kinase
RxyAA322_RS11795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RxyAA322_RS11810	COG4221	oxidoreductase activity
RxyAA322_RS11825	COG1051	belongs to the nudix hydrolase family
RxyAA322_RS11875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RxyAA322_RS11880	COG0187	DNA topoisomerase II activity
RxyAA322_RS11885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RxyAA322_RS11890	COG2501	S4 domain
RxyAA322_RS11895	COG0592	DNA-directed DNA polymerase activity
RxyAA322_RS11900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RxyAA322_RS11910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RxyAA322_RS11915	COG0594	ribonuclease P activity
RxyAA322_RS11920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RxyAA322_RS11925	COG0706	membrane insertase activity
RxyAA322_RS11930	COG1847	R3H domain protein
RxyAA322_RS11935	COG0357	Ribosomal RNA small subunit methyltransferase G
RxyAA322_RS11940	COG1192	Involved in chromosome partitioning
RxyAA322_RS11945	COG1475	DNA binding
RxyAA322_RS11960	COG2508	Transcriptional regulator
RxyAA322_RS11975	COG1836	PFAM Integral membrane protein DUF92
RxyAA322_RS11980	COG0495	leucyl-tRNA aminoacylation
RxyAA322_RS11985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RxyAA322_RS11995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RxyAA322_RS12005	COG0531	amino acid
RxyAA322_RS12015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RxyAA322_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS12045	COG4566	intracellular signal transduction
RxyAA322_RS12055	COG2197	response regulator
RxyAA322_RS12060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RxyAA322_RS12065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RxyAA322_RS12070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RxyAA322_RS12075	COG0509	glycine decarboxylation via glycine cleavage system
RxyAA322_RS12080	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
RxyAA322_RS12135	COG0366	Alpha amylase catalytic
RxyAA322_RS12150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RxyAA322_RS12150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RxyAA322_RS12155	COG0517	IMP dehydrogenase activity
RxyAA322_RS12155	COG1994	Peptidase M50
RxyAA322_RS12185	COG3328	transposase activity
RxyAA322_RS12195	COG3328	transposase activity
RxyAA322_RS12215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RxyAA322_RS12235	COG0535	radical SAM domain protein
RxyAA322_RS12250	COG0714	Associated with various cellular activities
RxyAA322_RS12270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RxyAA322_RS12270	COG2111	Na H antiporter
RxyAA322_RS12280	COG1006	Multisubunit Na H antiporter MnhC subunit
RxyAA322_RS12285	COG0651	ATP synthesis coupled electron transport
RxyAA322_RS12295	COG2212	antiporter activity
RxyAA322_RS12300	COG1320	monovalent cation:proton antiporter activity
RxyAA322_RS12330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RxyAA322_RS12335	COG0473	3-isopropylmalate dehydrogenase activity
RxyAA322_RS12340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RxyAA322_RS12345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RxyAA322_RS12350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RxyAA322_RS12360	COG0028	Belongs to the TPP enzyme family
RxyAA322_RS12365	COG0083	homoserine kinase activity
RxyAA322_RS12370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RxyAA322_RS12410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RxyAA322_RS12455	COG0463	Glycosyl transferase, family 2
RxyAA322_RS12465	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
RxyAA322_RS12475	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS12480	COG1091	dTDP-4-dehydrorhamnose reductase activity
RxyAA322_RS12535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RxyAA322_RS12555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RxyAA322_RS12560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RxyAA322_RS12580	COG4656	Part of a membrane complex involved in electron transport
RxyAA322_RS12585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RxyAA322_RS12600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RxyAA322_RS12605	COG1691	(AIR) carboxylase
RxyAA322_RS12615	COG0861	Integral membrane protein TerC family
RxyAA322_RS12625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RxyAA322_RS12630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RxyAA322_RS12635	COG3442	glutamine amidotransferase
RxyAA322_RS12645	COG0300	oxidoreductase activity
RxyAA322_RS12650	COG4948	Mandelate Racemase Muconate Lactonizing
RxyAA322_RS12655	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS12675	COG4948	Mandelate Racemase Muconate Lactonizing
RxyAA322_RS12680	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS12695	COG2186	Transcriptional regulator
RxyAA322_RS12700	COG1129	ABC transporter
RxyAA322_RS12705	COG1172	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS12725	COG1139	Iron-sulfur cluster binding protein
RxyAA322_RS12730	COG1556	Lactate utilization protein
RxyAA322_RS12745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RxyAA322_RS12750	COG3246	L-lysine catabolic process to acetate
RxyAA322_RS12760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RxyAA322_RS12770	COG0303	'Molybdopterin
RxyAA322_RS12785	COG0745	RESPONSE REGULATOR receiver
RxyAA322_RS12790	COG5002	protein histidine kinase activity
RxyAA322_RS12795	COG1994	Peptidase M50
RxyAA322_RS12805	COG0628	permease
RxyAA322_RS12810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RxyAA322_RS12820	COG0791	NLP P60 protein
RxyAA322_RS12825	COG0330	HflC and HflK could
RxyAA322_RS12830	COG2172	sigma factor antagonist activity
RxyAA322_RS12835	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS12885	COG2261	transglycosylase associated protein
RxyAA322_RS12890	COG2252	PERMEase
RxyAA322_RS12910	COG0723	plastoquinol--plastocyanin reductase activity
RxyAA322_RS12935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RxyAA322_RS12940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RxyAA322_RS12945	COG1116	anion transmembrane transporter activity
RxyAA322_RS12965	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
RxyAA322_RS13000	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS13010	COG0668	transmembrane transport
RxyAA322_RS13015	COG1181	Belongs to the D-alanine--D-alanine ligase family
RxyAA322_RS13035	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
RxyAA322_RS13045	COG2814	Major facilitator Superfamily
RxyAA322_RS13055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RxyAA322_RS13065	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RxyAA322_RS13070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RxyAA322_RS13085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RxyAA322_RS13090	COG1285	pathogenesis
RxyAA322_RS13115	COG0640	Transcriptional regulator
RxyAA322_RS13120	COG2423	ornithine cyclodeaminase activity
RxyAA322_RS13125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RxyAA322_RS13130	COG0733	neurotransmitter:sodium symporter activity
RxyAA322_RS13135	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS13140	COG0506	proline dehydrogenase activity
RxyAA322_RS13145	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS13150	COG0446	pyridine nucleotide-disulphide oxidoreductase
RxyAA322_RS13160	COG4191	Histidine kinase
RxyAA322_RS13160	COG0784	Response regulator, receiver
RxyAA322_RS13180	COG0559	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS13200	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RxyAA322_RS13205	COG1518	maintenance of DNA repeat elements
RxyAA322_RS13280	COG1183	phosphatidylcholine synthase activity
RxyAA322_RS13285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RxyAA322_RS13295	COG0180	Tryptophanyl-tRNA synthetase
RxyAA322_RS13310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RxyAA322_RS13315	COG0066	3-isopropylmalate dehydratase activity
RxyAA322_RS13355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RxyAA322_RS13365	COG0688	phosphatidylethanolamine metabolic process
RxyAA322_RS13370	COG1183	phosphatidylcholine synthase activity
RxyAA322_RS13375	COG1278	Cold shock
RxyAA322_RS13385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RxyAA322_RS13390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RxyAA322_RS13420	COG0542	response to heat
RxyAA322_RS13425	COG0625	glutathione transferase activity
RxyAA322_RS13450	COG0297	glycogen (starch) synthase activity
RxyAA322_RS13460	COG3540	Alkaline phosphatase
RxyAA322_RS13465	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
RxyAA322_RS13470	COG4085	toxin activity
RxyAA322_RS13470	COG1525	nuclease
RxyAA322_RS13470	COG0737	Belongs to the 5'-nucleotidase family
RxyAA322_RS13475	COG0584	glycerophosphoryl diester phosphodiesterase
RxyAA322_RS13490	COG3540	Alkaline phosphatase
RxyAA322_RS13500	COG1505	serine-type exopeptidase activity
RxyAA322_RS13505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RxyAA322_RS13510	COG0366	Alpha amylase catalytic
RxyAA322_RS13515	COG0366	Alpha amylase catalytic
RxyAA322_RS13520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RxyAA322_RS13530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RxyAA322_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS13560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RxyAA322_RS13565	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RxyAA322_RS13570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RxyAA322_RS13640	COG0070	glutamate synthase
RxyAA322_RS13640	COG0069	glutamate synthase activity
RxyAA322_RS13640	COG0067	glutamate synthase
RxyAA322_RS13650	COG2226	methyltransferase
RxyAA322_RS13655	COG1704	LemA family
RxyAA322_RS13660	COG0501	Belongs to the peptidase M48B family
RxyAA322_RS13675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS13680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RxyAA322_RS13695	COG3848	Pyruvate phosphate dikinase
RxyAA322_RS13695	COG0574	Belongs to the PEP-utilizing enzyme family
RxyAA322_RS13710	COG3848	Pyruvate phosphate dikinase
RxyAA322_RS13710	COG0574	Belongs to the PEP-utilizing enzyme family
RxyAA322_RS13720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RxyAA322_RS13730	COG0179	Fumarylacetoacetate (FAA) hydrolase
RxyAA322_RS13750	COG1309	transcriptional regulator
RxyAA322_RS13755	COG0318	PFAM AMP-dependent synthetase and ligase
RxyAA322_RS13760	COG1024	Enoyl-CoA hydratase
RxyAA322_RS13770	COG0477	Major facilitator Superfamily
RxyAA322_RS13775	COG1960	acyl-CoA dehydrogenase activity
RxyAA322_RS13790	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RxyAA322_RS13795	COG0745	RESPONSE REGULATOR receiver
RxyAA322_RS13800	COG5002	protein histidine kinase activity
RxyAA322_RS13815	COG1082	Xylose isomerase domain protein TIM barrel
RxyAA322_RS13825	COG1172	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS13835	COG1129	ABC transporter
RxyAA322_RS13840	COG1879	ABC-type sugar transport system periplasmic component
RxyAA322_RS13845	COG1940	carbohydrate kinase activity
RxyAA322_RS13850	COG1304	FMN binding
RxyAA322_RS13855	COG1940	carbohydrate kinase activity
RxyAA322_RS13865	COG1175	transmembrane transport
RxyAA322_RS13870	COG0395	ABC-type sugar transport system, permease component
RxyAA322_RS13875	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
RxyAA322_RS13885	COG1082	Xylose isomerase domain protein TIM barrel
RxyAA322_RS13890	COG1070	Carbohydrate kinase
RxyAA322_RS13895	COG0730	response to heat
RxyAA322_RS13905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RxyAA322_RS13915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RxyAA322_RS13925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RxyAA322_RS13940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RxyAA322_RS13970	COG4555	ABC transporter
RxyAA322_RS14015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RxyAA322_RS14020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RxyAA322_RS14025	COG1120	ATPase activity
RxyAA322_RS14050	COG0003	Pfam Anion-transporting ATPase
RxyAA322_RS14065	COG1966	Carbon starvation protein
RxyAA322_RS14080	COG1131	(ABC) transporter
RxyAA322_RS14085	COG1122	ATPase activity
RxyAA322_RS14090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RxyAA322_RS14110	COG2084	Dehydrogenase
RxyAA322_RS14175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RxyAA322_RS14190	COG1131	(ABC) transporter
RxyAA322_RS14215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RxyAA322_RS14225	COG3428	Bacterial PH domain
RxyAA322_RS14235	COG0419	ATPase involved in DNA repair
RxyAA322_RS14335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RxyAA322_RS14345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RxyAA322_RS14345	COG1796	DNA polymerase
RxyAA322_RS14360	COG2135	peptidase activity
RxyAA322_RS14365	COG2313	pseudouridylate synthase activity
RxyAA322_RS14380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RxyAA322_RS14420	COG0765	amino acid transport
RxyAA322_RS14425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RxyAA322_RS14435	COG1573	uracil-dna glycosylase
RxyAA322_RS14445	COG1522	sequence-specific DNA binding
RxyAA322_RS14460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RxyAA322_RS14465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RxyAA322_RS14470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RxyAA322_RS14475	COG1111	helicase
RxyAA322_RS14475	COG1205	dead DEAH box helicase
RxyAA322_RS14490	COG0586	Pfam SNARE associated Golgi protein
RxyAA322_RS14495	COG2267	carboxylic ester hydrolase activity
RxyAA322_RS14500	COG1692	metallophosphoesterase
RxyAA322_RS14515	COG1993	acr, cog1993
RxyAA322_RS14520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RxyAA322_RS14525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RxyAA322_RS14545	COG2188	Transcriptional regulator
RxyAA322_RS14555	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS14580	COG2721	sulfolactate sulfo-lyase activity
RxyAA322_RS14585	COG1012	belongs to the aldehyde dehydrogenase family
RxyAA322_RS14595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RxyAA322_RS14600	COG4948	Mandelate Racemase Muconate Lactonizing
RxyAA322_RS14615	COG1172	Belongs to the binding-protein-dependent transport system permease family
RxyAA322_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS14630	COG4948	Mandelate Racemase Muconate Lactonizing
RxyAA322_RS14640	COG2186	Transcriptional regulator
RxyAA322_RS14665	COG3314	Sporulation integral membrane protein YlbJ
RxyAA322_RS14670	COG2986	histidine ammonia-lyase
RxyAA322_RS14675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RxyAA322_RS14680	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RxyAA322_RS14690	COG1228	amidohydrolase
RxyAA322_RS14720	COG1742	UPF0060 membrane protein
RxyAA322_RS14735	COG0640	Transcriptional regulator
RxyAA322_RS14750	COG0519	Catalyzes the synthesis of GMP from XMP
RxyAA322_RS14755	COG0640	Transcriptional regulator
RxyAA322_RS14760	COG2226	methyltransferase
RxyAA322_RS14780	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RxyAA322_RS14785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RxyAA322_RS14810	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RxyAA322_RS14825	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RxyAA322_RS14835	COG0477	Major facilitator Superfamily
RxyAA322_RS14855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RxyAA322_RS14865	COG2188	Transcriptional regulator
RxyAA322_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS14885	COG1492	cobalamin metabolic process
RxyAA322_RS14905	COG1797	cobyrinic acid a,c-diamide synthase activity
RxyAA322_RS14920	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
RxyAA322_RS14950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RxyAA322_RS14955	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RxyAA322_RS14960	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RxyAA322_RS14965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RxyAA322_RS14975	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
RxyAA322_RS14980	COG1321	iron dependent repressor
RxyAA322_RS14985	COG1914	H( )-stimulated, divalent metal cation uptake system
RxyAA322_RS15005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RxyAA322_RS15010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RxyAA322_RS15015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RxyAA322_RS15020	COG3119	arylsulfatase activity
RxyAA322_RS15025	COG3119	arylsulfatase activity
RxyAA322_RS15050	COG0071	Belongs to the small heat shock protein (HSP20) family
RxyAA322_RS15065	COG0071	Belongs to the small heat shock protein (HSP20) family
RxyAA322_RS15070	COG0542	response to heat
RxyAA322_RS15090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RxyAA322_RS15095	COG3546	catalase activity
RxyAA322_RS15105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RxyAA322_RS15110	COG0121	glutamine amidotransferase
RxyAA322_RS15115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RxyAA322_RS15125	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS15155	COG0791	NLP P60 protein
RxyAA322_RS15160	COG0616	signal peptide processing
RxyAA322_RS15200	COG1501	Belongs to the glycosyl hydrolase 31 family
RxyAA322_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
RxyAA322_RS15210	COG2323	membrane
RxyAA322_RS15235	COG0859	PFAM glycosyl transferase family 9
RxyAA322_RS15240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RxyAA322_RS15240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RxyAA322_RS15245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RxyAA322_RS15250	COG0438	transferase activity, transferring glycosyl groups
RxyAA322_RS15260	COG0859	PFAM glycosyl transferase family 9
RxyAA322_RS15270	COG2192	nodulation
RxyAA322_RS15285	COG1063	alcohol dehydrogenase
RxyAA322_RS15310	COG1090	epimerase
RxyAA322_RS15315	COG0287	Prephenate dehydrogenase