locus-tag	class	description
D1823_RS00005	COG2046	Belongs to the sulfate adenylyltransferase family
D1823_RS00005	COG0529	Catalyzes the synthesis of activated sulfate
D1823_RS00015	COG0492	ferredoxin-NADP+ reductase activity
D1823_RS00020	COG1522	sequence-specific DNA binding
D1823_RS00035	COG1496	oxidoreductase activity
D1823_RS00045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1823_RS00065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1823_RS00075	COG1435	thymidine kinase activity
D1823_RS00095	COG1846	Transcriptional regulator
D1823_RS00110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1823_RS00115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1823_RS00115	COG0512	Glutamine amidotransferase of anthranilate synthase
D1823_RS00130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1823_RS00140	COG0346	lactoylglutathione lyase activity
D1823_RS00155	COG0778	Nitroreductase
D1823_RS00160	COG1872	DUF167
D1823_RS00175	COG1739	Uncharacterized protein family UPF0029
D1823_RS00210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1823_RS00225	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D1823_RS00250	COG0625	glutathione transferase activity
D1823_RS00270	COG0583	DNA-binding transcription factor activity
D1823_RS00275	COG0483	inositol monophosphate 1-phosphatase activity
D1823_RS00290	COG1522	sequence-specific DNA binding
D1823_RS00300	COG2186	Transcriptional regulator
D1823_RS00305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1823_RS00320	COG0277	FAD linked oxidase domain protein
D1823_RS00340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1823_RS00345	COG2084	Dehydrogenase
D1823_RS00360	COG0300	oxidoreductase activity
D1823_RS00365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1823_RS00370	COG0385	Bile acid
D1823_RS00375	COG2072	flavoprotein involved in K transport
D1823_RS00400	COG1309	transcriptional regulator
D1823_RS00405	COG1960	acyl-CoA dehydrogenase activity
D1823_RS00415	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS00420	COG0583	DNA-binding transcription factor activity
D1823_RS00425	COG0583	DNA-binding transcription factor activity
D1823_RS00490	COG0010	Belongs to the arginase family
D1823_RS00505	COG1166	arginine decarboxylase activity
D1823_RS00560	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS00565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS00580	COG5598	trimethylamine methyltransferase
D1823_RS00585	COG2072	flavoprotein involved in K transport
D1823_RS00590	COG2267	carboxylic ester hydrolase activity
D1823_RS00615	COG0582	viral genome integration into host DNA
D1823_RS00660	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1823_RS00665	COG1129	ABC transporter
D1823_RS00685	COG1129	ABC transporter
D1823_RS00690	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1823_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS00705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1823_RS00715	COG3734	2-keto-3-deoxy-galactonokinase
D1823_RS00720	COG0800	Aldolase
D1823_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS00745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1823_RS00745	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1823_RS00755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1823_RS00775	COG1349	DNA-binding transcription factor activity
D1823_RS00780	COG3842	ATPase activity
D1823_RS00790	COG1175	transmembrane transport
D1823_RS00795	COG0395	ABC-type sugar transport system, permease component
D1823_RS00800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1823_RS00815	COG0514	ATP-dependent DNA helicase (RecQ)
D1823_RS00830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1823_RS00845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1823_RS00850	COG5328	Belongs to the UPF0262 family
D1823_RS00875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1823_RS00880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1823_RS00895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1823_RS00915	COG3321	synthase
D1823_RS00915	COG0604	alcohol dehydrogenase
D1823_RS00915	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS00935	COG0405	Gamma-glutamyltransferase
D1823_RS00940	COG0277	FAD linked oxidase domain protein
D1823_RS00955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1823_RS00985	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS01015	COG1737	Transcriptional regulator
D1823_RS01025	COG1132	(ABC) transporter
D1823_RS01030	COG0318	PFAM AMP-dependent synthetase and ligase
D1823_RS01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1823_RS01060	COG0601	transmembrane transport
D1823_RS01070	COG2379	hydroxypyruvate reductase
D1823_RS01075	COG1490	D-aminoacyl-tRNA deacylase activity
D1823_RS01105	COG3853	Toxic anion resistance protein (TelA)
D1823_RS01120	COG0590	tRNA wobble adenosine to inosine editing
D1823_RS01125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1823_RS01140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1823_RS01145	COG0154	amidase activity
D1823_RS01185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1823_RS01195	COG0670	Belongs to the BI1 family
D1823_RS01205	COG0583	DNA-binding transcription factor activity
D1823_RS01215	COG1396	sequence-specific DNA binding
D1823_RS01220	COG0483	inositol monophosphate 1-phosphatase activity
D1823_RS01230	COG0402	S-adenosylhomocysteine deaminase activity
D1823_RS01235	COG2239	Acts as a magnesium transporter
D1823_RS01240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1823_RS01250	COG1692	metallophosphoesterase
D1823_RS01255	COG0471	metal ion transport
D1823_RS01255	COG3273	potassium ion transport
D1823_RS01275	COG0519	Catalyzes the synthesis of GMP from XMP
D1823_RS01275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1823_RS01280	COG0471	metal ion transport
D1823_RS01280	COG3273	potassium ion transport
D1823_RS01285	COG0217	transcriptional regulatory protein
D1823_RS01320	COG3119	arylsulfatase activity
D1823_RS01340	COG1396	sequence-specific DNA binding
D1823_RS01340	COG3800	Transcriptional regulator
D1823_RS01345	COG2814	Major facilitator Superfamily
D1823_RS01350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1823_RS01375	COG4770	biotin carboxylase activity
D1823_RS01385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1823_RS01385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1823_RS01400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1823_RS01415	COG0248	Ppx GppA phosphatase
D1823_RS01425	COG0628	permease
D1823_RS01440	COG0442	prolyl-tRNA aminoacylation
D1823_RS01460	COG1136	(ABC) transporter
D1823_RS01490	COG2113	Glycine betaine
D1823_RS01495	COG4175	Glycine betaine
D1823_RS01495	COG0517	IMP dehydrogenase activity
D1823_RS01500	COG4176	ABC-type proline glycine betaine transport system permease component
D1823_RS01520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1823_RS01535	COG1832	CoA-binding protein
D1823_RS01545	COG0140	phosphoribosyl-ATP diphosphatase activity
D1823_RS01550	COG0107	imidazoleglycerol-phosphate synthase activity
D1823_RS01570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1823_RS01580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1823_RS01585	COG0131	Imidazoleglycerol-phosphate dehydratase
D1823_RS01615	COG3788	relative of glutathione S-transferase, MAPEG superfamily
D1823_RS01620	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D1823_RS01655	COG2001	Belongs to the MraZ family
D1823_RS01660	COG0275	rRNA processing
D1823_RS01675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1823_RS01680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1823_RS01685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1823_RS01695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1823_RS01705	COG2081	HI0933 family
D1823_RS01710	COG1396	sequence-specific DNA binding
D1823_RS01710	COG1917	Cupin 2, conserved barrel domain protein
D1823_RS01720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1823_RS01725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1823_RS01745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1823_RS01750	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1823_RS01755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1823_RS01760	COG0849	cell division
D1823_RS01770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1823_RS01780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1823_RS01810	COG0006	proline dipeptidase activity
D1823_RS01855	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1823_RS01860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1823_RS01875	COG0308	aminopeptidase N
D1823_RS01880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1823_RS01890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1823_RS01900	COG2010	Cytochrome c
D1823_RS01900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1823_RS01910	COG1309	transcriptional regulator
D1823_RS01930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1823_RS01945	COG0738	Major facilitator superfamily
D1823_RS01950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1823_RS01955	COG0601	transmembrane transport
D1823_RS01965	COG4172	Belongs to the ABC transporter superfamily
D1823_RS01970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1823_RS01975	COG1473	amidohydrolase
D1823_RS01980	COG1473	amidohydrolase
D1823_RS01985	COG1473	amidohydrolase
D1823_RS01990	COG1519	Transferase
D1823_RS01995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1823_RS02015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1823_RS02020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1823_RS02025	COG0546	phosphoglycolate phosphatase activity
D1823_RS02030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1823_RS02035	COG1960	acyl-CoA dehydrogenase activity
D1823_RS02040	COG3047	cAMP biosynthetic process
D1823_RS02045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1823_RS02055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1823_RS02065	COG4770	biotin carboxylase activity
D1823_RS02075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1823_RS02085	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1823_RS02090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1823_RS02095	COG0649	NAD binding
D1823_RS02140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1823_RS02145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1823_RS02160	COG0713	ATP synthesis coupled electron transport
D1823_RS02175	COG1007	ATP synthesis coupled electron transport
D1823_RS02185	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1823_RS02210	COG1595	DNA-templated transcription, initiation
D1823_RS02235	COG0546	phosphoglycolate phosphatase activity
D1823_RS02250	COG5001	Diguanylate cyclase
D1823_RS02250	COG3447	MASE1 domain protein
D1823_RS02250	COG5002	protein histidine kinase activity
D1823_RS02265	COG1234	tRNA 3'-trailer cleavage
D1823_RS02270	COG0084	hydrolase, TatD family'
D1823_RS02280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1823_RS02285	COG1686	Belongs to the peptidase S11 family
D1823_RS02310	COG0582	viral genome integration into host DNA
D1823_RS02420	COG3119	arylsulfatase activity
D1823_RS02520	COG1535	isochorismatase
D1823_RS02520	COG3433	isochorismatase activity
D1823_RS02535	COG0174	glutamine synthetase
D1823_RS02560	COG3064	Membrane
D1823_RS02615	COG0531	amino acid
D1823_RS02635	COG0589	response to stress
D1823_RS02655	COG1175	transmembrane transport
D1823_RS02660	COG0395	ABC-type sugar transport system, permease component
D1823_RS02675	COG3842	ATPase activity
D1823_RS02685	COG1609	Transcriptional regulator
D1823_RS02695	COG0673	inositol 2-dehydrogenase activity
D1823_RS02720	COG4175	Glycine betaine
D1823_RS02720	COG3448	diguanylate cyclase activity
D1823_RS02725	COG4176	ABC-type proline glycine betaine transport system permease component
D1823_RS02745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1823_RS02750	COG0583	DNA-binding transcription factor activity
D1823_RS02760	COG2326	polyphosphate kinase activity
D1823_RS02765	COG0534	Mate efflux family protein
D1823_RS02805	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D1823_RS02810	COG1278	Cold shock
D1823_RS02815	COG1393	Belongs to the ArsC family
D1823_RS02835	COG3220	belongs to the UPF0276 family
D1823_RS02845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1823_RS02880	COG3243	poly(R)-hydroxyalkanoic acid synthase
D1823_RS02895	COG0583	DNA-binding transcription factor activity
D1823_RS02925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1823_RS02930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS02935	COG0174	glutamine synthetase
D1823_RS02940	COG0519	Catalyzes the synthesis of GMP from XMP
D1823_RS02955	COG2080	2 iron, 2 sulfur cluster binding
D1823_RS02960	COG1309	transcriptional regulator
D1823_RS02965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1823_RS02970	COG0730	response to heat
D1823_RS02995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1823_RS03005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS03015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1823_RS03015	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1823_RS03040	COG1408	metallophosphoesterase
D1823_RS03060	COG5265	(ABC) transporter
D1823_RS03085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1823_RS03090	COG1160	GTP binding
D1823_RS03105	COG3239	Fatty acid desaturase
D1823_RS03115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1823_RS03120	COG0668	transmembrane transport
D1823_RS03130	COG1862	Preprotein translocase
D1823_RS03135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1823_RS03140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1823_RS03150	COG3737	Protein of unknown function (DUF498/DUF598)
D1823_RS03155	COG4133	protoheme IX ABC transporter activity
D1823_RS03160	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1823_RS03165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1823_RS03175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1823_RS03180	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS03190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1823_RS03215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1823_RS03245	COG0006	proline dipeptidase activity
D1823_RS03280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1823_RS03290	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1823_RS03300	COG2197	response regulator
D1823_RS03310	COG0359	binds to the 23S rRNA
D1823_RS03315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1823_RS03320	COG0360	Binds together with S18 to 16S ribosomal RNA
D1823_RS03330	COG2353	YceI-like domain
D1823_RS03335	COG3038	cytochrome b561
D1823_RS03340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1823_RS03350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1823_RS03360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1823_RS03365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1823_RS03370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1823_RS03375	COG0513	Belongs to the DEAD box helicase family
D1823_RS03405	COG4695	Portal protein
D1823_RS03505	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1823_RS03510	COG0022	dehydrogenase e1 component
D1823_RS03510	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1823_RS03515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1823_RS03520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D1823_RS03530	COG0126	phosphoglycerate kinase activity
D1823_RS03550	COG3228	Belongs to the MtfA family
D1823_RS03560	COG0739	heme binding
D1823_RS03565	COG2833	Protein of unknown function (DUF455)
D1823_RS03570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1823_RS03580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1823_RS03600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1823_RS03610	COG0156	8-amino-7-oxononanoate synthase activity
D1823_RS03620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1823_RS03640	COG0436	Aminotransferase
D1823_RS03645	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1823_RS03650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1823_RS03660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1823_RS03690	COG0028	Belongs to the TPP enzyme family
D1823_RS03735	COG0346	lactoylglutathione lyase activity
D1823_RS03740	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D1823_RS03770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1823_RS03785	COG0306	phosphate transporter
D1823_RS03815	COG0542	response to heat
D1823_RS03825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1823_RS03835	COG0316	Belongs to the HesB IscA family
D1823_RS03840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1823_RS03850	COG0018	arginyl-trna synthetase
D1823_RS03865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D1823_RS03870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1823_RS03880	COG0717	Belongs to the dCTP deaminase family
D1823_RS03895	COG0776	regulation of translation
D1823_RS03900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1823_RS03905	COG0416	fatty acid biosynthetic process
D1823_RS03910	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1823_RS03930	COG0488	(ABC) transporter
D1823_RS03955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1823_RS03960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1823_RS03985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D1823_RS04005	COG0697	spore germination
D1823_RS04010	COG0148	phosphopyruvate hydratase activity
D1823_RS04025	COG3956	TIGRFAM MazG family protein
D1823_RS04030	COG1473	amidohydrolase
D1823_RS04035	COG0010	Belongs to the arginase family
D1823_RS04060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1823_RS04065	COG2890	protein-(glutamine-N5) methyltransferase activity
D1823_RS04075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1823_RS04080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D1823_RS04090	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1823_RS04100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1823_RS04110	COG0667	Aldo Keto reductase
D1823_RS04115	COG4977	sequence-specific DNA binding
D1823_RS04120	COG3246	L-lysine catabolic process to acetate
D1823_RS04130	COG0824	Thioesterase
D1823_RS04130	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1823_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS04165	COG0513	Belongs to the DEAD box helicase family
D1823_RS04180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D1823_RS04190	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS04195	COG4335	DNA alkylation repair
D1823_RS04200	COG2226	methyltransferase
D1823_RS04205	COG3842	ATPase activity
D1823_RS04210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D1823_RS04215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1823_RS04220	COG1388	LysM domain
D1823_RS04220	COG0739	heme binding
D1823_RS04225	COG2378	regulation of single-species biofilm formation
D1823_RS04235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1823_RS04240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1823_RS04245	COG0805	protein transport
D1823_RS04255	COG4221	oxidoreductase activity
D1823_RS04265	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1823_RS04300	COG1127	ABC transporter
D1823_RS04305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1823_RS04310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1823_RS04325	COG0305	Participates in initiation and elongation during chromosome replication
D1823_RS04330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1823_RS04335	COG0004	ammonium transporteR
D1823_RS04340	COG1546	Belongs to the CinA family
D1823_RS04350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D1823_RS04350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1823_RS04355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1823_RS04360	COG3852	Histidine kinase
D1823_RS04365	COG2204	response regulator
D1823_RS04370	COG5000	phosphorelay sensor kinase activity
D1823_RS04375	COG2204	response regulator
D1823_RS04385	COG0569	domain protein
D1823_RS04390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1823_RS04395	COG1923	regulation of RNA biosynthetic process
D1823_RS04400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1823_RS04415	COG2366	antibiotic biosynthetic process
D1823_RS04435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1823_RS04445	COG2814	Major facilitator Superfamily
D1823_RS04455	COG0318	PFAM AMP-dependent synthetase and ligase
D1823_RS04470	COG4166	transmembrane transport
D1823_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS04490	COG2313	pseudouridylate synthase activity
D1823_RS04505	COG0352	thiamine-phosphate diphosphorylase activity
D1823_RS04515	COG1612	heme a metabolic process
D1823_RS04520	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D1823_RS04535	COG1272	protein, Hemolysin III
D1823_RS04540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1823_RS04545	COG5425	PFAM Usg family protein
D1823_RS04560	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1823_RS04570	COG0166	Belongs to the GPI family
D1823_RS04575	COG0318	PFAM AMP-dependent synthetase and ligase
D1823_RS04610	COG1715	Restriction endonuclease
D1823_RS04660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1823_RS04665	COG2205	protein histidine kinase activity
D1823_RS04680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1823_RS04685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1823_RS04690	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1823_RS04700	COG2166	iron-sulfur cluster assembly
D1823_RS04715	COG5012	cobalamin binding
D1823_RS04725	COG0372	Belongs to the citrate synthase family
D1823_RS04730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1823_RS04735	COG2333	competence protein COMEC
D1823_RS04735	COG0658	competence protein
D1823_RS04740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1823_RS04745	COG0303	'Molybdopterin
D1823_RS04755	COG0134	indole-3-glycerol-phosphate synthase activity
D1823_RS04760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1823_RS04775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1823_RS04790	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1823_RS04795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1823_RS04800	COG0259	pyridoxamine-phosphate oxidase activity
D1823_RS04805	COG1278	Cold shock
D1823_RS04825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1823_RS04835	COG5598	trimethylamine methyltransferase
D1823_RS04860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1823_RS04870	COG2814	Major facilitator Superfamily
D1823_RS04905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1823_RS04910	COG1238	metal cluster binding
D1823_RS04925	COG2358	TRAP transporter, solute receptor (TAXI family
D1823_RS04945	COG0577	efflux transmembrane transporter activity
D1823_RS04960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1823_RS04970	COG3119	arylsulfatase activity
D1823_RS05005	COG0714	Associated with various cellular activities
D1823_RS05010	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1823_RS05015	COG0628	permease
D1823_RS05030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1823_RS05035	COG0248	Ppx GppA phosphatase
D1823_RS05050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1823_RS05060	COG2326	polyphosphate kinase activity
D1823_RS05070	COG1609	Transcriptional regulator
D1823_RS05085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1823_RS05090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1823_RS05090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1823_RS05095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1823_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS05105	COG1063	alcohol dehydrogenase
D1823_RS05120	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
D1823_RS05120	COG0028	Belongs to the TPP enzyme family
D1823_RS05140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1823_RS05140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1823_RS05155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1823_RS05165	COG3119	arylsulfatase activity
D1823_RS05180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1823_RS05200	COG1217	gtp-binding protein TYPA
D1823_RS05220	COG2945	thiolester hydrolase activity
D1823_RS05225	COG1959	2 iron, 2 sulfur cluster binding
D1823_RS05235	COG0719	Fe-S assembly protein
D1823_RS05245	COG0396	ATPase activity
D1823_RS05250	COG0719	Fe-S assembly protein
D1823_RS05265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1823_RS05275	COG0583	DNA-binding transcription factor activity
D1823_RS05280	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1823_RS05280	COG1902	pentaerythritol trinitrate reductase activity
D1823_RS05295	COG3108	Peptidase M15
D1823_RS05305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1823_RS05310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1823_RS05325	COG0433	COG0433 Predicted ATPase
D1823_RS05365	COG0683	leucine binding
D1823_RS05370	COG2133	pyrroloquinoline quinone binding
D1823_RS05385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1823_RS05395	COG1561	YicC-like family, N-terminal region
D1823_RS05400	COG0194	GDP metabolic process
D1823_RS05410	COG5002	protein histidine kinase activity
D1823_RS05420	COG0573	inorganic phosphate transmembrane transporter activity
D1823_RS05430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1823_RS05440	COG0745	RESPONSE REGULATOR receiver
D1823_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS05450	COG1946	Acyl-CoA thioesterase
D1823_RS05455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1823_RS05475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1823_RS05480	COG2771	luxR family
D1823_RS05485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1823_RS05490	COG0052	Belongs to the universal ribosomal protein uS2 family
D1823_RS05515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1823_RS05520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1823_RS05525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1823_RS05540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1823_RS05545	COG3743	rRNA binding
D1823_RS05545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1823_RS05595	COG1022	Amp-dependent synthetase and ligase
D1823_RS05610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1823_RS05620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1823_RS05635	COG1024	Enoyl-CoA hydratase
D1823_RS05640	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D1823_RS05645	COG2264	protein methyltransferase activity
D1823_RS05650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1823_RS05655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1823_RS05665	COG2095	MarC family integral membrane protein
D1823_RS05675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1823_RS05690	COG0482	sulfurtransferase activity
D1823_RS05705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1823_RS05715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1823_RS05720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1823_RS05730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1823_RS05735	COG0750	zinc metalloprotease
D1823_RS05740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D1823_RS05750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1823_RS05755	COG0233	cytoplasmic translational termination
D1823_RS05760	COG0604	alcohol dehydrogenase
D1823_RS05765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1823_RS05785	COG2186	Transcriptional regulator
D1823_RS05840	COG0114	fumarate hydratase activity
D1823_RS05855	COG2818	Glycosylase
D1823_RS05860	COG3588	fructose-bisphosphate aldolase
D1823_RS05865	COG2124	cytochrome p450
D1823_RS05875	COG0785	Cytochrome C biogenesis protein
D1823_RS05880	COG0425	Belongs to the sulfur carrier protein TusA family
D1823_RS05885	COG1530	ribonuclease E activity
D1823_RS05885	COG1530	ribonuclease E activity
D1823_RS05890	COG2204	response regulator
D1823_RS05900	COG0047	phosphoribosylformylglycinamidine synthase activity
D1823_RS05910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1823_RS05915	COG2095	MarC family integral membrane protein
D1823_RS05920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1823_RS05930	COG0646	methionine synthase
D1823_RS05930	COG1410	methionine synthase
D1823_RS05935	COG1024	Enoyl-CoA hydratase
D1823_RS05940	COG3088	subunit of a heme lyase
D1823_RS05945	COG1138	Cytochrome C-type biogenesis protein
D1823_RS05960	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D1823_RS05965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1823_RS05970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1823_RS05990	COG0668	transmembrane transport
D1823_RS05995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1823_RS06010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1823_RS06030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1823_RS06040	COG2354	Protein conserved in bacteria
D1823_RS06055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1823_RS06060	COG0517	IMP dehydrogenase activity
D1823_RS06060	COG0617	tRNA 3'-terminal CCA addition
D1823_RS06060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1823_RS06080	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1823_RS06090	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1823_RS06115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1823_RS06135	COG0531	amino acid
D1823_RS06140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1823_RS06150	COG0343	queuine tRNA-ribosyltransferase activity
D1823_RS06160	COG0330	HflC and HflK could
D1823_RS06170	COG2151	metal-sulfur cluster biosynthetic enzyme
D1823_RS06180	COG0316	Belongs to the HesB IscA family
D1823_RS06185	COG0149	triose-phosphate isomerase activity
D1823_RS06195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1823_RS06200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1823_RS06205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1823_RS06210	COG2204	response regulator
D1823_RS06225	COG1522	sequence-specific DNA binding
D1823_RS06230	COG1648	precorrin-2 dehydrogenase activity
D1823_RS06230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1823_RS06240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1823_RS06245	COG0175	sulfate reduction
D1823_RS06260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1823_RS06270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1823_RS06290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1823_RS06305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1823_RS06310	COG0418	dihydroorotase activity
D1823_RS06320	COG2867	negative regulation of translational initiation
D1823_RS06325	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1823_RS06335	COG1473	amidohydrolase
D1823_RS06340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1823_RS06360	COG5598	trimethylamine methyltransferase
D1823_RS06370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1823_RS06370	COG0519	Catalyzes the synthesis of GMP from XMP
D1823_RS06375	COG0697	spore germination
D1823_RS06395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D1823_RS06405	COG2326	polyphosphate kinase activity
D1823_RS06410	COG1309	transcriptional regulator
D1823_RS06425	COG0010	Belongs to the arginase family
D1823_RS06435	COG1177	transmembrane transport
D1823_RS06440	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1823_RS06450	COG3842	ATPase activity
D1823_RS06460	COG0006	proline dipeptidase activity
D1823_RS06465	COG0006	proline dipeptidase activity
D1823_RS06470	COG0583	DNA-binding transcription factor activity
D1823_RS06480	COG2267	carboxylic ester hydrolase activity
D1823_RS06490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1823_RS06495	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS06510	COG1063	alcohol dehydrogenase
D1823_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS06525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1823_RS06530	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1823_RS06535	COG0129	dihydroxy-acid dehydratase activity
D1823_RS06540	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS06550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1823_RS06565	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS06585	COG2721	sulfolactate sulfo-lyase activity
D1823_RS06595	COG2084	Dehydrogenase
D1823_RS06600	COG0697	spore germination
D1823_RS06605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1823_RS06610	COG0246	Mannitol dehydrogenase
D1823_RS06615	COG1904	glucuronate isomerase
D1823_RS06620	COG0673	inositol 2-dehydrogenase activity
D1823_RS06635	COG1312	Catalyzes the dehydration of D-mannonate
D1823_RS06650	COG0432	Pfam Uncharacterised protein family UPF0047
D1823_RS06655	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS06660	COG1063	alcohol dehydrogenase
D1823_RS06665	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS06675	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS06700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1823_RS06725	COG3264	Mechanosensitive ion channel
D1823_RS06725	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1823_RS06735	COG0494	nUDIX hydrolase
D1823_RS06745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1823_RS06750	COG0415	Belongs to the DNA photolyase family
D1823_RS06755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1823_RS06760	COG0528	UMP kinase activity
D1823_RS06765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1823_RS06775	COG0601	transmembrane transport
D1823_RS06780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1823_RS06785	COG4172	Belongs to the ABC transporter superfamily
D1823_RS06800	COG0741	lytic transglycosylase activity
D1823_RS06805	COG0629	single-stranded DNA binding
D1823_RS06810	COG0517	IMP dehydrogenase activity
D1823_RS06810	COG1994	Peptidase M50
D1823_RS06815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1823_RS06820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1823_RS06830	COG4974	Belongs to the 'phage' integrase family
D1823_RS06835	COG4536	flavin adenine dinucleotide binding
D1823_RS06850	COG0746	molybdenum cofactor guanylyltransferase activity
D1823_RS06855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1823_RS06860	COG0745	RESPONSE REGULATOR receiver
D1823_RS06865	COG0642	Histidine kinase
D1823_RS06870	COG2954	triphosphatase activity
D1823_RS06875	COG1192	Involved in chromosome partitioning
D1823_RS06890	COG0105	UTP biosynthetic process
D1823_RS06900	COG0488	(ABC) transporter
D1823_RS06910	COG2095	MarC family integral membrane protein
D1823_RS06925	COG2271	Major facilitator Superfamily
D1823_RS06945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1823_RS06965	COG1349	DNA-binding transcription factor activity
D1823_RS06970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1823_RS06980	COG1566	PFAM secretion protein HlyD family protein
D1823_RS06990	COG0392	lysyltransferase activity
D1823_RS06990	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D1823_RS07000	COG0010	Belongs to the arginase family
D1823_RS07030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1823_RS07045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1823_RS07060	COG5002	protein histidine kinase activity
D1823_RS07060	COG2176	DNA-directed DNA polymerase activity
D1823_RS07080	COG0489	protein tyrosine kinase activity
D1823_RS07115	COG3383	formate dehydrogenase (NAD+) activity
D1823_RS07115	COG0243	molybdopterin cofactor binding
D1823_RS07120	COG0437	4 iron, 4 sulfur cluster binding
D1823_RS07135	COG3474	cytochrome
D1823_RS07165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1823_RS07170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1823_RS07195	COG1309	transcriptional regulator
D1823_RS07205	COG2226	methyltransferase
D1823_RS07210	COG0493	'glutamate synthase
D1823_RS07220	COG2873	o-acetylhomoserine
D1823_RS07230	COG2968	Membrane
D1823_RS07255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1823_RS07260	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1823_RS07265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1823_RS07270	COG1329	Transcriptional regulator
D1823_RS07275	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D1823_RS07350	COG0564	pseudouridine synthase activity
D1823_RS07415	COG0321	lipoyl(octanoyl) transferase activity
D1823_RS07425	COG0789	Transcriptional regulator
D1823_RS07430	COG0537	adenosine 5'-monophosphoramidase activity
D1823_RS07455	COG0505	Belongs to the CarA family
D1823_RS07465	COG1802	Transcriptional regulator
D1823_RS07480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1823_RS07495	COG1522	sequence-specific DNA binding
D1823_RS07505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1823_RS07515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1823_RS07520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1823_RS07525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1823_RS07530	COG2132	Multicopper oxidase
D1823_RS07540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1823_RS07540	COG0574	Belongs to the PEP-utilizing enzyme family
D1823_RS07545	COG0751	glycine-tRNA ligase activity
D1823_RS07550	COG0786	glutamate:sodium symporter activity
D1823_RS07560	COG2095	MarC family integral membrane protein
D1823_RS07565	COG0752	glycyl-tRNA synthetase alpha subunit
D1823_RS07580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1823_RS07590	COG1469	GTP cyclohydrolase I activity
D1823_RS07600	COG0625	glutathione transferase activity
D1823_RS07610	COG0587	DNA-directed DNA polymerase activity
D1823_RS07645	COG0559	Belongs to the binding-protein-dependent transport system permease family
D1823_RS07675	COG2072	flavoprotein involved in K transport
D1823_RS07680	COG3284	Transcriptional regulator
D1823_RS07685	COG0318	PFAM AMP-dependent synthetase and ligase
D1823_RS07690	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS07710	COG1609	Transcriptional regulator
D1823_RS07720	COG1570	exodeoxyribonuclease VII activity
D1823_RS07740	COG0552	protein localization to endoplasmic reticulum
D1823_RS07750	COG2917	probably involved in intracellular septation
D1823_RS07770	COG0330	HflC and HflK could
D1823_RS07785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1823_RS07795	COG1760	l-serine dehydratase
D1823_RS07830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1823_RS07855	COG0504	CTP synthase activity
D1823_RS07865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1823_RS07900	COG4215	(ABC) transporter
D1823_RS07930	COG0640	Transcriptional regulator
D1823_RS07945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1823_RS07950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1823_RS07970	COG1596	polysaccharide export
D1823_RS07980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1823_RS07980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1823_RS07985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1823_RS07990	COG0432	Pfam Uncharacterised protein family UPF0047
D1823_RS08015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1823_RS08020	COG0358	DNA primase activity
D1823_RS08030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1823_RS08055	COG1741	Belongs to the pirin family
D1823_RS08060	COG1309	transcriptional regulator
D1823_RS08080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1823_RS08095	COG1349	DNA-binding transcription factor activity
D1823_RS08100	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
D1823_RS08105	COG1394	ATPase activity, coupled to movement of substances
D1823_RS08120	COG3842	ATPase activity
D1823_RS08125	COG3842	ATPase activity
D1823_RS08130	COG1175	transmembrane transport
D1823_RS08135	COG0395	ABC-type sugar transport system, permease component
D1823_RS08160	COG2115	Belongs to the xylose isomerase family
D1823_RS08170	COG4214	carbohydrate transport
D1823_RS08175	COG4213	ABC transporter substrate-binding protein
D1823_RS08180	COG1940	carbohydrate kinase activity
D1823_RS08190	COG1858	cytochrome C peroxidase
D1823_RS08200	COG1070	Carbohydrate kinase
D1823_RS08205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1823_RS08210	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D1823_RS08225	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1823_RS08245	COG0039	L-malate dehydrogenase activity
D1823_RS08250	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D1823_RS08255	COG1454	alcohol dehydrogenase
D1823_RS08255	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS08270	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
D1823_RS08295	COG0069	glutamate synthase activity
D1823_RS08305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1823_RS08325	COG0644	oxidoreductase
D1823_RS08330	COG0142	geranyltranstransferase activity
D1823_RS08340	COG1404	Belongs to the peptidase S8 family
D1823_RS08355	COG0187	DNA topoisomerase II activity
D1823_RS08365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1823_RS08395	COG0463	Glycosyl transferase, family 2
D1823_RS08400	COG0354	folic acid binding
D1823_RS08410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1823_RS08425	COG1492	cobalamin metabolic process
D1823_RS08440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1823_RS08485	COG0471	metal ion transport
D1823_RS08485	COG3273	potassium ion transport
D1823_RS08525	COG2099	Precorrin-6x reductase
D1823_RS08540	COG2875	Belongs to the precorrin methyltransferase family
D1823_RS08545	COG1797	cobyrinic acid a,c-diamide synthase activity
D1823_RS08550	COG1648	precorrin-2 dehydrogenase activity
D1823_RS08550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1823_RS08570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1823_RS08585	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D1823_RS08605	COG2111	Na H antiporter
D1823_RS08605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1823_RS08610	COG1006	Multisubunit Na H antiporter MnhC subunit
D1823_RS08615	COG0651	ATP synthesis coupled electron transport
D1823_RS08625	COG2212	antiporter activity
D1823_RS08630	COG1320	monovalent cation:proton antiporter activity
D1823_RS08635	COG0709	Synthesizes selenophosphate from selenide and ATP
D1823_RS08640	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D1823_RS08645	COG2135	peptidase activity
D1823_RS08650	COG0737	Belongs to the 5'-nucleotidase family
D1823_RS08665	COG0167	dihydroorotate dehydrogenase activity
D1823_RS08675	COG0534	Mate efflux family protein
D1823_RS08695	COG0789	Transcriptional regulator
D1823_RS08700	COG1960	acyl-CoA dehydrogenase activity
D1823_RS08710	COG0435	Glutathione S-transferase
D1823_RS08715	COG0183	Belongs to the thiolase family
D1823_RS08725	COG1024	Enoyl-CoA hydratase
D1823_RS08725	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1823_RS08735	COG0697	spore germination
D1823_RS08745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1823_RS08750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1823_RS08755	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D1823_RS08760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D1823_RS08765	COG0295	cytidine deaminase activity
D1823_RS08780	COG0280	phosphate acetyltransferase
D1823_RS08780	COG0281	malic enzyme
D1823_RS08795	COG0154	amidase activity
D1823_RS08805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1823_RS08840	COG1054	Belongs to the UPF0176 family
D1823_RS08865	COG2197	response regulator
D1823_RS08910	COG2985	domain, Protein
D1823_RS08930	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1823_RS08935	COG0559	Belongs to the binding-protein-dependent transport system permease family
D1823_RS08945	COG0829	nickel cation binding
D1823_RS08950	COG0831	urea catabolic process
D1823_RS08955	COG0832	Belongs to the urease beta subunit family
D1823_RS08960	COG0804	urea catabolic process
D1823_RS08970	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D1823_RS08975	COG0830	nickel cation binding
D1823_RS08980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1823_RS08990	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1823_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS09015	COG3119	arylsulfatase activity
D1823_RS09020	COG4638	Rieske (2fe-2S)
D1823_RS09025	COG0028	Belongs to the TPP enzyme family
D1823_RS09055	COG2391	methyltransferase activity
D1823_RS09060	COG0156	8-amino-7-oxononanoate synthase activity
D1823_RS09070	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1823_RS09075	COG3474	cytochrome
D1823_RS09085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1823_RS09090	COG0737	Belongs to the 5'-nucleotidase family
D1823_RS09095	COG3258	Cytochrome c
D1823_RS09120	COG0785	Cytochrome C biogenesis protein
D1823_RS09130	COG0640	Transcriptional regulator
D1823_RS09135	COG2391	methyltransferase activity
D1823_RS09140	COG3750	Belongs to the UPF0335 family
D1823_RS09195	COG0745	RESPONSE REGULATOR receiver
D1823_RS09200	COG1396	sequence-specific DNA binding
D1823_RS09200	COG3800	Transcriptional regulator
D1823_RS09215	COG0439	Biotin carboxylase
D1823_RS09220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D1823_RS09245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1823_RS09250	COG0740	serine-type endopeptidase activity
D1823_RS09285	COG0481	GTPase activity
D1823_RS09300	COG0583	DNA-binding transcription factor activity
D1823_RS09310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1823_RS09330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1823_RS09335	COG1703	isobutyryl-CoA mutase activity
D1823_RS09340	COG1643	Atp-dependent helicase
D1823_RS09350	COG0306	phosphate transporter
D1823_RS09355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1823_RS09360	COG1741	Belongs to the pirin family
D1823_RS09380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1823_RS09385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1823_RS09395	COG0842	Transport permease protein
D1823_RS09425	COG0525	valine-tRNA ligase activity
D1823_RS09430	COG3135	benzoate transporter
D1823_RS09440	COG1024	Enoyl-CoA hydratase
D1823_RS09450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1823_RS09455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1823_RS09460	COG0800	Aldolase
D1823_RS09465	COG0129	dihydroxy-acid dehydratase activity
D1823_RS09470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1823_RS09475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1823_RS09480	COG0527	aspartate kinase activity
D1823_RS09525	COG0659	secondary active sulfate transmembrane transporter activity
D1823_RS09535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1823_RS09545	COG1280	lysine exporter protein (LysE YggA)
D1823_RS09555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1823_RS09560	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1823_RS09590	COG3346	SURF1 family
D1823_RS09600	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D1823_RS09605	COG0109	protoheme IX farnesyltransferase activity
D1823_RS09615	COG0312	modulator of DNA gyrase
D1823_RS09620	COG0758	DNA mediated transformation
D1823_RS09625	COG1754	DNA topoisomerase type I activity
D1823_RS09625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1823_RS09635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D1823_RS09660	COG4964	Belongs to the GSP D family
D1823_RS09710	COG1201	RNA secondary structure unwinding
D1823_RS09725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1823_RS09735	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D1823_RS09745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1823_RS09750	COG0037	tRNA processing
D1823_RS09760	COG2885	chlorophyll binding
D1823_RS09765	COG0823	Involved in the tonB-independent uptake of proteins
D1823_RS09785	COG0824	Thioesterase
D1823_RS09795	COG2255	four-way junction helicase activity
D1823_RS09800	COG0632	four-way junction helicase activity
D1823_RS09805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1823_RS09835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1823_RS09850	COG1183	phosphatidylcholine synthase activity
D1823_RS09860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1823_RS09870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1823_RS09895	COG3768	UPF0283 membrane protein
D1823_RS09905	COG3106	COG3106 Predicted ATPase
D1823_RS09910	COG0101	tRNA pseudouridine synthase activity
D1823_RS09935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1823_RS09950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1823_RS09965	COG3383	formate dehydrogenase (NAD+) activity
D1823_RS09975	COG0583	DNA-binding transcription factor activity
D1823_RS09985	COG0012	GTP binding
D1823_RS09995	COG0159	tryptophan synthase activity
D1823_RS10005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1823_RS10010	COG0193	aminoacyl-tRNA hydrolase activity
D1823_RS10030	COG0133	tryptophan synthase activity
D1823_RS10035	COG0135	phosphoribosylanthranilate isomerase activity
D1823_RS10045	COG0776	regulation of translation
D1823_RS10050	COG0539	negative regulation of cytoplasmic translation
D1823_RS10080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1823_RS10085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1823_RS10090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1823_RS10095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1823_RS10100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1823_RS10110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1823_RS10115	COG1702	phosphate starvation-inducible protein PhoH
D1823_RS10125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1823_RS10140	COG0583	DNA-binding transcription factor activity
D1823_RS10150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1823_RS10155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1823_RS10160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1823_RS10170	COG1047	Peptidyl-prolyl cis-trans
D1823_RS10190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1823_RS10210	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS10220	COG1132	(ABC) transporter
D1823_RS10270	COG0747	negative chemotaxis
D1823_RS10275	COG0601	transmembrane transport
D1823_RS10280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1823_RS10285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1823_RS10290	COG0668	transmembrane transport
D1823_RS10305	COG0438	transferase activity, transferring glycosyl groups
D1823_RS10310	COG0588	phosphoglycerate mutase activity
D1823_RS10330	COG3454	Phosphonate metabolism
D1823_RS10345	COG4778	phosphonate C-P lyase system protein PhnL
D1823_RS10365	COG3624	Phosphonate C-P lyase system protein PhnG
D1823_RS10380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1823_RS10390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1823_RS10400	COG0300	oxidoreductase activity
D1823_RS10410	COG2096	Adenosyltransferase
D1823_RS10430	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1823_RS10440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1823_RS10450	COG1660	Displays ATPase and GTPase activities
D1823_RS10460	COG2205	protein histidine kinase activity
D1823_RS10465	COG0745	RESPONSE REGULATOR receiver
D1823_RS10470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D1823_RS10505	COG1381	Involved in DNA repair and RecF pathway recombination
D1823_RS10530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1823_RS10535	COG2132	Multicopper oxidase
D1823_RS10545	COG0571	ribonuclease III activity
D1823_RS10550	COG0681	Belongs to the peptidase S26 family
D1823_RS10555	COG0736	holo-[acyl-carrier-protein] synthase activity
D1823_RS10560	COG1280	lysine exporter protein (LysE YggA)
D1823_RS10565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D1823_RS10575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1823_RS10580	COG1758	RNA polymerase activity
D1823_RS10585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1823_RS10595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1823_RS10610	COG0328	RNA-DNA hybrid ribonuclease activity
D1823_RS10640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1823_RS10645	COG0242	peptide deformylase activity
D1823_RS10650	COG0242	peptide deformylase activity
D1823_RS10655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D1823_RS10665	COG0435	Glutathione S-transferase
D1823_RS10680	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1823_RS10710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1823_RS10725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1823_RS10730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1823_RS10735	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1823_RS10740	COG0356	it plays a direct role in the translocation of protons across the membrane
D1823_RS10755	COG0589	response to stress
D1823_RS10770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1823_RS10800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1823_RS10825	COG0228	four-way junction DNA binding
D1823_RS10830	COG0778	Nitroreductase
D1823_RS10835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1823_RS10845	COG0336	Belongs to the RNA methyltransferase TrmD family
D1823_RS10860	COG0335	large ribosomal subunit rRNA binding
D1823_RS10865	COG0254	rRNA binding
D1823_RS10875	COG0477	Major facilitator Superfamily
D1823_RS10885	COG2151	metal-sulfur cluster biosynthetic enzyme
D1823_RS10885	COG0489	protein tyrosine kinase activity
D1823_RS10895	COG2226	methyltransferase
D1823_RS10910	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1823_RS10915	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1823_RS10935	COG0625	glutathione transferase activity
D1823_RS10945	COG0318	PFAM AMP-dependent synthetase and ligase
D1823_RS10950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1823_RS10965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1823_RS10970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1823_RS10975	COG1115	amino acid carrier protein
D1823_RS10985	COG1522	sequence-specific DNA binding
D1823_RS10990	COG0469	pyruvate kinase activity
D1823_RS11015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1823_RS11020	COG0842	Transport permease protein
D1823_RS11020	COG1129	ABC transporter
D1823_RS11025	COG0842	Transport permease protein
D1823_RS11035	COG3243	poly(R)-hydroxyalkanoic acid synthase
D1823_RS11065	COG0543	2 iron, 2 sulfur cluster binding
D1823_RS11065	COG0633	Ferredoxin
D1823_RS11090	COG2989	Protein conserved in bacteria
D1823_RS11105	COG2197	response regulator
D1823_RS11130	COG1215	transferase activity, transferring glycosyl groups
D1823_RS11155	COG2204	response regulator
D1823_RS11160	COG4191	Histidine kinase
D1823_RS11185	COG0583	DNA-binding transcription factor activity
D1823_RS11190	COG0583	DNA-binding transcription factor activity
D1823_RS11195	COG0625	glutathione transferase activity
D1823_RS11205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1823_RS11205	COG1017	nitric oxide dioxygenase activity
D1823_RS11235	COG2828	Protein conserved in bacteria
D1823_RS11255	COG1802	Transcriptional regulator
D1823_RS11260	COG1053	succinate dehydrogenase
D1823_RS11280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1823_RS11345	COG1858	cytochrome C peroxidase
D1823_RS11360	COG3485	protocatechuate 3,4-dioxygenase
D1823_RS11385	COG0778	Nitroreductase
D1823_RS11390	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1823_RS11400	COG1802	Transcriptional regulator
D1823_RS11410	COG0318	PFAM AMP-dependent synthetase and ligase
D1823_RS11425	COG3246	L-lysine catabolic process to acetate
D1823_RS11430	COG4177	L-phenylalanine transmembrane transporter activity
D1823_RS11445	COG1137	ATPase activity
D1823_RS11455	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1823_RS11485	COG1840	ABC-type Fe3 transport system, periplasmic component
D1823_RS11495	COG3842	ATPase activity
D1823_RS11615	COG4191	Histidine kinase
D1823_RS11625	COG0398	Pfam SNARE associated Golgi protein
D1823_RS11630	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1823_RS11635	COG0594	ribonuclease P activity
D1823_RS11640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1823_RS11645	COG1960	acyl-CoA dehydrogenase activity
D1823_RS11650	COG0037	tRNA processing
D1823_RS11655	COG4251	negative regulation of phosphorylation
D1823_RS11655	COG5001	Diguanylate cyclase
D1823_RS11655	COG3706	GGDEF domain
D1823_RS11655	COG2203	Gaf domain
D1823_RS11660	COG0706	membrane insertase activity
D1823_RS11670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1823_RS11675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1823_RS11690	COG1126	abc transporter atp-binding protein
D1823_RS11695	COG0765	amino acid transport
D1823_RS11700	COG4597	amino acid ABC transporter
D1823_RS11705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1823_RS11715	COG0546	phosphoglycolate phosphatase activity
D1823_RS11720	COG0564	pseudouridine synthase activity
D1823_RS11725	COG1024	Enoyl-CoA hydratase
D1823_RS11730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1823_RS11735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1823_RS11740	COG0203	ribosomal protein L17
D1823_RS11745	COG0202	RNA polymerase activity
D1823_RS11750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1823_RS11755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1823_RS11760	COG0563	adenylate kinase activity
D1823_RS11765	COG0201	protein transport
D1823_RS11770	COG0200	Binds to the 23S rRNA
D1823_RS11775	COG3239	Fatty acid desaturase
D1823_RS11780	COG3119	arylsulfatase activity
D1823_RS11790	COG1278	Cold shock
D1823_RS11795	COG1376	ErfK ybiS ycfS ynhG family protein
D1823_RS11805	COG4181	ATPase activity
D1823_RS11815	COG1959	2 iron, 2 sulfur cluster binding
D1823_RS11825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1823_RS11835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1823_RS11840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS11860	COG0300	oxidoreductase activity
D1823_RS11865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1823_RS11870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1823_RS11890	COG0768	penicillin binding
D1823_RS11895	COG0772	Belongs to the SEDS family
D1823_RS11900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1823_RS11905	COG0339	signal peptide processing
D1823_RS11910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1823_RS11915	COG0756	dUTP diphosphatase activity
D1823_RS11920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1823_RS11950	COG0606	chelatase, subunit chli
D1823_RS11960	COG0792	nuclease activity
D1823_RS11965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1823_RS11975	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D1823_RS11990	COG0180	Tryptophanyl-tRNA synthetase
D1823_RS12010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D1823_RS12015	COG1214	PFAM Peptidase M22, glycoprotease
D1823_RS12020	COG0456	acetyltransferase
D1823_RS12025	COG1744	ABC transporter substrate-binding protein PnrA-like
D1823_RS12030	COG3845	ABC transporter
D1823_RS12035	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1823_RS12040	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1823_RS12045	COG0730	response to heat
D1823_RS12050	COG0730	response to heat
D1823_RS12060	COG4221	oxidoreductase activity
D1823_RS12065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1823_RS12085	COG0604	alcohol dehydrogenase
D1823_RS12090	COG2937	Belongs to the GPAT DAPAT family
D1823_RS12095	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1823_RS12095	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1823_RS12105	COG0813	purine-nucleoside phosphorylase activity
D1823_RS12155	COG2030	dehydratase
D1823_RS12185	COG0039	L-malate dehydrogenase activity
D1823_RS12195	COG0045	succinate-CoA ligase (ADP-forming) activity
D1823_RS12215	COG3152	Membrane
D1823_RS12220	COG0567	Dehydrogenase, E1 component
D1823_RS12240	COG1309	transcriptional regulator
D1823_RS12265	COG2884	Cell division ATP-binding protein ftsE
D1823_RS12280	COG0019	diaminopimelate decarboxylase activity
D1823_RS12290	COG0165	Argininosuccinate lyase
D1823_RS12295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1823_RS12335	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS12340	COG0583	DNA-binding transcription factor activity
D1823_RS12365	COG0142	geranyltranstransferase activity
D1823_RS12370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1823_RS12385	COG0789	Transcriptional regulator
D1823_RS12395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1823_RS12420	COG0746	molybdenum cofactor guanylyltransferase activity
D1823_RS12430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1823_RS12475	COG1960	acyl-CoA dehydrogenase activity
D1823_RS12480	COG0009	L-threonylcarbamoyladenylate synthase
D1823_RS12485	COG1678	Uncharacterized ACR, COG1678
D1823_RS12500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1823_RS12510	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1823_RS12520	COG1573	uracil-dna glycosylase
D1823_RS12530	COG0540	Belongs to the ATCase OTCase family
D1823_RS12550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1823_RS12580	COG1063	alcohol dehydrogenase
D1823_RS12590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1823_RS12600	COG2326	polyphosphate kinase activity
D1823_RS12610	COG1522	sequence-specific DNA binding
D1823_RS12615	COG0686	Belongs to the AlaDH PNT family
D1823_RS12620	COG0668	transmembrane transport
D1823_RS12625	COG0625	glutathione transferase activity
D1823_RS12635	COG0072	phenylalanine-tRNA ligase activity
D1823_RS12635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1823_RS12650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1823_RS12680	COG3047	cAMP biosynthetic process
D1823_RS12680	COG2885	chlorophyll binding
D1823_RS12695	COG0314	molybdopterin synthase activity
D1823_RS12705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1823_RS12715	COG0322	excinuclease ABC activity
D1823_RS12735	COG0842	Transport permease protein
D1823_RS12740	COG1131	(ABC) transporter
D1823_RS12745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1823_RS12750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1823_RS12755	COG0181	hydroxymethylbilane synthase activity
D1823_RS12760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1823_RS12765	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS12770	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS12775	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS12780	COG1917	Cupin 2, conserved barrel domain protein
D1823_RS12785	COG0604	alcohol dehydrogenase
D1823_RS12885	COG2801	Transposase and inactivated derivatives
D1823_RS12890	COG2423	ornithine cyclodeaminase activity
D1823_RS12900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1823_RS12905	COG0436	Aminotransferase
D1823_RS12915	COG0579	oxidoreductase
D1823_RS12960	COG1566	PFAM secretion protein HlyD family protein
D1823_RS12965	COG0577	efflux transmembrane transporter activity
D1823_RS12965	COG1136	(ABC) transporter
D1823_RS12995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1823_RS13000	COG0628	permease
D1823_RS13025	COG1305	Transglutaminase-like
D1823_RS13035	COG2308	Evidence 4 Homologs of previously reported genes of
D1823_RS13040	COG4566	intracellular signal transduction
D1823_RS13045	COG3842	ATPase activity
D1823_RS13055	COG1177	transmembrane transport
D1823_RS13060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1823_RS13080	COG3119	arylsulfatase activity
D1823_RS13130	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D1823_RS13135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1823_RS13165	COG0284	orotidine-5'-phosphate decarboxylase activity
D1823_RS13170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1823_RS13185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1823_RS13195	COG1840	ABC-type Fe3 transport system, periplasmic component
D1823_RS13200	COG1396	sequence-specific DNA binding
D1823_RS13205	COG0456	acetyltransferase
D1823_RS13225	COG0583	DNA-binding transcription factor activity
D1823_RS13230	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D1823_RS13235	COG1794	racemase activity, acting on amino acids and derivatives
D1823_RS13240	COG0583	DNA-binding transcription factor activity
D1823_RS13250	COG3448	diguanylate cyclase activity
D1823_RS13250	COG4175	Glycine betaine
D1823_RS13255	COG4176	ABC-type proline glycine betaine transport system permease component
D1823_RS13260	COG2267	carboxylic ester hydrolase activity
D1823_RS13280	COG0546	phosphoglycolate phosphatase activity
D1823_RS13370	COG0235	Class ii aldolase
D1823_RS13375	COG3395	kinase activity
D1823_RS13405	COG0473	3-isopropylmalate dehydrogenase activity
D1823_RS13435	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D1823_RS13465	COG0583	DNA-binding transcription factor activity
D1823_RS13495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1823_RS13510	COG2423	ornithine cyclodeaminase activity
D1823_RS13555	COG0668	transmembrane transport
D1823_RS13560	COG0668	transmembrane transport
D1823_RS13685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1823_RS13710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1823_RS13720	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1823_RS13725	COG0268	Binds directly to 16S ribosomal RNA
D1823_RS13735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1823_RS13740	COG2226	methyltransferase
D1823_RS13750	COG0183	Belongs to the thiolase family
D1823_RS13755	COG1396	sequence-specific DNA binding
D1823_RS13760	COG0156	8-amino-7-oxononanoate synthase activity
D1823_RS13770	COG1063	alcohol dehydrogenase
D1823_RS13775	COG3483	tryptophan 2,3-dioxygenase activity
D1823_RS13780	COG0657	acetylesterase activity
D1823_RS13785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1823_RS13800	COG0779	Required for maturation of 30S ribosomal subunits
D1823_RS13805	COG0747	negative chemotaxis
D1823_RS13815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1823_RS13830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1823_RS13840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1823_RS13870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1823_RS13875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1823_RS13880	COG1137	ATPase activity
D1823_RS13895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1823_RS13895	COG0517	IMP dehydrogenase activity
D1823_RS13900	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1823_RS13910	COG2814	Major facilitator Superfamily
D1823_RS13915	COG1522	sequence-specific DNA binding
D1823_RS13925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D1823_RS13935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D1823_RS13950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D1823_RS13960	COG4786	Flagellar basal body rod
D1823_RS13965	COG4786	Flagellar basal body rod
D1823_RS13970	COG1987	bacterial-type flagellum assembly
D1823_RS13975	COG1677	Flagellar hook-basal body complex protein FliE
D1823_RS13980	COG1558	bacterial-type flagellum-dependent cell motility
D1823_RS13985	COG1815	bacterial-type flagellum-dependent cell motility
D1823_RS13995	COG1360	Flagellar Motor Protein
D1823_RS14015	COG1706	bacterial-type flagellum-dependent cell motility
D1823_RS14070	COG0071	Belongs to the small heat shock protein (HSP20) family
D1823_RS14085	COG0247	lactate metabolic process
D1823_RS14090	COG0277	FAD linked oxidase domain protein
D1823_RS14095	COG0277	FAD linked oxidase domain protein
D1823_RS14110	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1823_RS14115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1823_RS14120	COG0799	negative regulation of ribosome biogenesis
D1823_RS14125	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1823_RS14125	COG3264	Mechanosensitive ion channel
D1823_RS14135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1823_RS14145	COG0066	3-isopropylmalate dehydratase activity
D1823_RS14175	COG0473	3-isopropylmalate dehydrogenase activity
D1823_RS14180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1823_RS14185	COG0347	Belongs to the P(II) protein family
D1823_RS14190	COG0004	ammonium transporteR
D1823_RS14205	COG2897	thiosulfate sulfurtransferase activity
D1823_RS14215	COG1396	sequence-specific DNA binding
D1823_RS14220	COG0129	dihydroxy-acid dehydratase activity
D1823_RS14240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1823_RS14260	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS14280	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D1823_RS14290	COG2963	transposase activity
D1823_RS14340	COG0235	Class ii aldolase
D1823_RS14350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1823_RS14355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1823_RS14375	COG0697	spore germination
D1823_RS14390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1823_RS14400	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1823_RS14410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1823_RS14435	COG1968	undecaprenyl-diphosphatase activity
D1823_RS14490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D1823_RS14510	COG3119	arylsulfatase activity
D1823_RS14550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1823_RS14555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1823_RS14585	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1823_RS14595	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D1823_RS14610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D1823_RS14615	COG1999	signal sequence binding
D1823_RS14635	COG3178	'Phosphotransferase
D1823_RS14640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1823_RS14650	COG1074	ATP-dependent DNA helicase activity
D1823_RS14675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D1823_RS14685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D1823_RS14715	COG3030	protein affecting phage T7 exclusion by the F plasmid
D1823_RS14720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D1823_RS14725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1823_RS14730	COG0237	dephospho-CoA kinase activity
D1823_RS14735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1823_RS14740	COG0424	maF-like protein
D1823_RS14745	COG1981	membrane
D1823_RS14750	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1823_RS14755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D1823_RS14760	COG0445	tRNA wobble uridine modification
D1823_RS14765	COG0357	Ribosomal RNA small subunit methyltransferase G
D1823_RS14780	COG2832	Protein of unknown function (DUF454)
D1823_RS14785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1823_RS14790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1823_RS14795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1823_RS14800	COG1420	regulation of RNA biosynthetic process
D1823_RS14805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1823_RS14810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1823_RS14815	COG0281	malic enzyme
D1823_RS14815	COG0280	phosphate acetyltransferase
D1823_RS14825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1823_RS14840	COG0137	argininosuccinate synthase activity
D1823_RS14850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1823_RS14860	COG0745	RESPONSE REGULATOR receiver
D1823_RS14880	COG0617	tRNA 3'-terminal CCA addition
D1823_RS14885	COG1132	(ABC) transporter
D1823_RS14890	COG1132	(ABC) transporter
D1823_RS14930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1823_RS14935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D1823_RS14940	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1823_RS14955	COG0443	Heat shock 70 kDa protein
D1823_RS14965	COG0484	heat shock protein binding
D1823_RS14970	COG0351	phosphomethylpyrimidine kinase
D1823_RS14985	COG2022	thiamine diphosphate biosynthetic process
D1823_RS14995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1823_RS15000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1823_RS15005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1823_RS15010	COG1116	anion transmembrane transporter activity
D1823_RS15015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1823_RS15020	COG2003	Belongs to the UPF0758 family
D1823_RS15025	COG2885	chlorophyll binding
D1823_RS15035	COG0653	protein targeting
D1823_RS15040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1823_RS15045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1823_RS15050	COG0494	nUDIX hydrolase
D1823_RS15060	COG1022	Amp-dependent synthetase and ligase
D1823_RS15070	COG0559	Belongs to the binding-protein-dependent transport system permease family
D1823_RS15100	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1823_RS15105	COG1178	ABC-type Fe3 transport system permease component
D1823_RS15115	COG0791	NLP P60 protein
D1823_RS15120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1823_RS15130	COG0288	reversible hydration of carbon dioxide
D1823_RS15150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1823_RS15190	COG1609	Transcriptional regulator
D1823_RS15195	COG3214	Protein conserved in bacteria
D1823_RS15220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1823_RS15225	COG1846	Transcriptional regulator
D1823_RS15230	COG0745	RESPONSE REGULATOR receiver
D1823_RS15235	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1823_RS15240	COG1722	exodeoxyribonuclease VII activity
D1823_RS15245	COG0142	geranyltranstransferase activity
D1823_RS15250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1823_RS15265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1823_RS15275	COG0798	PFAM Bile acid sodium symporter
D1823_RS15290	COG1418	mRNA catabolic process
D1823_RS15295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1823_RS15305	COG2808	Putative FMN-binding domain
D1823_RS15310	COG3474	cytochrome
D1823_RS15335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1823_RS15340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1823_RS15385	COG4974	Belongs to the 'phage' integrase family
D1823_RS15445	COG1024	Enoyl-CoA hydratase
D1823_RS15455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1823_RS15470	COG1609	Transcriptional regulator
D1823_RS15480	COG1175	transmembrane transport
D1823_RS15490	COG3842	ATPase activity
D1823_RS15495	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D1823_RS15505	COG1902	pentaerythritol trinitrate reductase activity
D1823_RS15525	COG1228	amidohydrolase
D1823_RS15560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1823_RS15570	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D1823_RS15585	COG3046	protein related to deoxyribodipyrimidine photolyase
D1823_RS15590	COG0415	Belongs to the DNA photolyase family
D1823_RS15600	COG0415	Belongs to the DNA photolyase family
D1823_RS15610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1823_RS15630	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS15640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1823_RS15645	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1823_RS15645	COG3608	succinylglutamate desuccinylase aspartoacylase
D1823_RS15710	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1823_RS15715	COG4221	oxidoreductase activity
D1823_RS15730	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1823_RS15735	COG0697	spore germination
D1823_RS15745	COG0587	DNA-directed DNA polymerase activity
D1823_RS15755	COG1131	(ABC) transporter
D1823_RS15770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1823_RS15770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1823_RS15780	COG3622	Belongs to the hyi family
D1823_RS15800	COG0714	Associated with various cellular activities
D1823_RS15820	COG4953	penicillin-binding protein 1C
D1823_RS15825	COG2373	Large extracellular alpha-helical protein
D1823_RS15830	COG5002	protein histidine kinase activity
D1823_RS15830	COG0784	Response regulator, receiver
D1823_RS15830	COG2205	protein histidine kinase activity
D1823_RS15835	COG3022	response to hydroperoxide
D1823_RS15840	COG0514	ATP-dependent DNA helicase (RecQ)
D1823_RS15855	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D1823_RS15880	COG3191	aminopeptidase activity
D1823_RS15885	COG3474	cytochrome
D1823_RS15890	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1823_RS15895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1823_RS15900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1823_RS15905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1823_RS15910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1823_RS15915	COG0747	negative chemotaxis
D1823_RS15930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1823_RS15950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D1823_RS15960	COG1335	isochorismatase
D1823_RS15965	COG1054	Belongs to the UPF0176 family
D1823_RS15995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D1823_RS16015	COG1766	The M ring may be actively involved in energy transduction
D1823_RS16030	COG1338	Plays a role in the flagellum-specific transport system
D1823_RS16050	COG0584	glycerophosphoryl diester phosphodiesterase
D1823_RS16060	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1823_RS16080	COG0678	peroxiredoxin activity
D1823_RS16090	COG0742	ribosomal rna small subunit methyltransferase
D1823_RS16095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1823_RS16105	COG0024	Methionine aminopeptidase
D1823_RS16120	COG1489	DNA binding
D1823_RS16125	COG1546	Belongs to the CinA family
D1823_RS16125	COG1058	Belongs to the CinA family
D1823_RS16155	COG0583	DNA-binding transcription factor activity
D1823_RS16175	COG1902	pentaerythritol trinitrate reductase activity
D1823_RS16175	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1823_RS16180	COG1051	belongs to the nudix hydrolase family
D1823_RS16190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1823_RS16195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1823_RS16200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1823_RS16215	COG0450	alkyl hydroperoxide reductase
D1823_RS16250	COG1185	polyribonucleotide nucleotidyltransferase activity
D1823_RS16255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1823_RS16265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1823_RS16280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1823_RS16290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1823_RS16295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1823_RS16315	COG2175	clavaminate synthase activity
D1823_RS16340	COG0138	bifunctional purine biosynthesis protein purh
D1823_RS16345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1823_RS16355	COG0612	Peptidase, M16
D1823_RS16360	COG0612	Peptidase, M16
D1823_RS16365	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS16370	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS16375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D1823_RS16380	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1823_RS16385	COG1121	(ABC) transporter
D1823_RS16390	COG1321	iron dependent repressor
D1823_RS16390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1823_RS16395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1823_RS16420	COG3806	Anti-sigma factor
D1823_RS16425	COG1595	DNA-templated transcription, initiation
D1823_RS16470	COG0625	glutathione transferase activity
D1823_RS16485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1823_RS16490	COG0509	glycine decarboxylation via glycine cleavage system
D1823_RS16495	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1823_RS16495	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1823_RS16505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1823_RS16510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1823_RS16515	COG0560	Phosphoserine phosphatase
D1823_RS16545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1823_RS16555	COG0826	peptidase U32
D1823_RS16565	COG0484	heat shock protein binding
D1823_RS16575	COG0626	cystathionine gamma-synthase activity
D1823_RS16595	COG2171	N-acyltransferase activity
D1823_RS16610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1823_RS16615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1823_RS16625	COG0557	exoribonuclease II activity
D1823_RS16645	COG2951	lytic endotransglycosylase activity
D1823_RS16655	COG1802	Transcriptional regulator
D1823_RS16665	COG3842	ATPase activity
D1823_RS16670	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1823_RS16675	COG1177	transmembrane transport
D1823_RS16680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS16690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D1823_RS16750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1823_RS16765	COG3239	Fatty acid desaturase
D1823_RS16770	COG1194	a g-specific adenine glycosylase
D1823_RS16785	COG1663	tetraacyldisaccharide 4'-kinase activity
D1823_RS16795	COG0483	inositol monophosphate 1-phosphatase activity
D1823_RS16800	COG0312	modulator of DNA gyrase
D1823_RS16830	COG2081	HI0933 family
D1823_RS16845	COG0495	leucyl-tRNA aminoacylation
D1823_RS16860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1823_RS16875	COG0745	RESPONSE REGULATOR receiver
D1823_RS16900	COG2835	tetraacyldisaccharide 4'-kinase activity
D1823_RS16905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1823_RS16915	COG0436	Aminotransferase
D1823_RS16920	COG1674	ftsk spoiiie
D1823_RS16945	COG0405	Gamma-glutamyltransferase
D1823_RS16950	COG2172	sigma factor antagonist activity
D1823_RS17000	COG1063	alcohol dehydrogenase
D1823_RS17005	COG2040	homocysteine
D1823_RS17035	COG0564	pseudouridine synthase activity
D1823_RS17050	COG2885	chlorophyll binding
D1823_RS17055	COG0431	NADPH-dependent FMN reductase
D1823_RS17060	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D1823_RS17070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1823_RS17070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS17080	COG0741	lytic transglycosylase activity
D1823_RS17085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1823_RS17095	COG0437	4 iron, 4 sulfur cluster binding
D1823_RS17100	COG0243	molybdopterin cofactor binding
D1823_RS17105	COG0280	phosphate acetyltransferase
D1823_RS17110	COG0028	Belongs to the TPP enzyme family
D1823_RS17115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1823_RS17150	COG0406	alpha-ribazole phosphatase activity
D1823_RS17155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1823_RS17160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1823_RS17200	COG1162	GTPase activity
D1823_RS17210	COG0737	Belongs to the 5'-nucleotidase family
D1823_RS17215	COG2816	NAD+ diphosphatase activity
D1823_RS17230	COG0077	Prephenate dehydratase
D1823_RS17230	COG1605	Chorismate mutase
D1823_RS17240	COG4166	transmembrane transport
D1823_RS17245	COG4174	ABC transporter (Permease)
D1823_RS17250	COG4239	(ABC) transporter, permease
D1823_RS17255	COG4172	Belongs to the ABC transporter superfamily
D1823_RS17265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1823_RS17270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1823_RS17300	COG2010	Cytochrome c
D1823_RS17310	COG0348	domain, Protein
D1823_RS17330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1823_RS17335	COG0250	Participates in transcription elongation, termination and antitermination
D1823_RS17345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1823_RS17350	COG0081	regulation of translation
D1823_RS17360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1823_RS17365	COG0222	ribosome binding
D1823_RS17370	COG0085	RNA polymerase activity
D1823_RS17375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1823_RS17385	COG0697	spore germination
D1823_RS17400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1823_RS17405	COG0049	tRNA binding
D1823_RS17410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1823_RS17415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1823_RS17430	COG0051	transcription antitermination factor activity, RNA binding
D1823_RS17435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1823_RS17440	COG0088	Forms part of the polypeptide exit tunnel
D1823_RS17445	COG0089	rRNA binding
D1823_RS17475	COG1841	ribosomal large subunit assembly
D1823_RS17480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1823_RS17485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1823_RS17490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1823_RS17495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1823_RS17500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1823_RS17505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1823_RS17510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1823_RS17515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1823_RS17520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1823_RS17525	COG0255	Belongs to the universal ribosomal protein uL29 family
D1823_RS17535	COG1278	Cold shock
D1823_RS17545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1823_RS17550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1823_RS17555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1823_RS17560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1823_RS17565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1823_RS17575	COG0488	(ABC) transporter
D1823_RS17585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1823_RS17600	COG2076	Multidrug Resistance protein
D1823_RS17605	COG2226	methyltransferase
D1823_RS17610	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D1823_RS17665	COG0556	nucleotide-excision repair
D1823_RS17690	COG0673	inositol 2-dehydrogenase activity
D1823_RS17700	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1823_RS17710	COG3962	Belongs to the TPP enzyme family
D1823_RS17725	COG3718	enzyme involved in inositol metabolism
D1823_RS17735	COG3622	Belongs to the hyi family
D1823_RS17740	COG0191	fructose-bisphosphate aldolase activity
D1823_RS17750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1823_RS17755	COG0673	inositol 2-dehydrogenase activity
D1823_RS17760	COG0673	inositol 2-dehydrogenase activity
D1823_RS17765	COG1609	Transcriptional regulator
D1823_RS17775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1823_RS17815	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1823_RS17820	COG4149	molybdate abc transporter
D1823_RS17825	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1823_RS17845	COG0408	coproporphyrinogen oxidase activity
D1823_RS17855	COG2813	Specifically methylates the guanine in position
D1823_RS17860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1823_RS17870	COG1686	Belongs to the peptidase S11 family
D1823_RS17880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D1823_RS17885	COG1984	allophanate hydrolase subunit 2
D1823_RS17955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1823_RS17970	COG0410	ABC transporter
D1823_RS17980	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1823_RS18045	COG2207	Transcriptional regulator
D1823_RS18045	COG3708	Transcriptional regulator
D1823_RS18060	COG1309	transcriptional regulator
D1823_RS18065	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1823_RS18070	COG1177	transmembrane transport
D1823_RS18075	COG3842	ATPase activity
D1823_RS18080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1823_RS18100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1823_RS18120	COG0582	viral genome integration into host DNA
D1823_RS18145	COG2951	lytic endotransglycosylase activity
D1823_RS18150	COG0825	malonyl-CoA metabolic process
D1823_RS18170	COG2301	Belongs to the HpcH HpaI aldolase family
D1823_RS18180	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS18195	COG1653	transport
D1823_RS18205	COG0395	ABC-type sugar transport system, permease component
D1823_RS18210	COG3842	ATPase activity
D1823_RS18225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1823_RS18230	COG1522	sequence-specific DNA binding
D1823_RS18240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1823_RS18245	COG0287	Prephenate dehydrogenase
D1823_RS18260	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D1823_RS18285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1823_RS18295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1823_RS18300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1823_RS18305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1823_RS18310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1823_RS18315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1823_RS18325	COG0698	ribose 5-phosphate isomerase
D1823_RS18340	COG2267	carboxylic ester hydrolase activity
D1823_RS18350	COG2983	Belongs to the UPF0260 family
D1823_RS18355	COG0196	riboflavin kinase activity
D1823_RS18370	COG2030	dehydratase
D1823_RS18400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1823_RS18405	COG0459	protein refolding
D1823_RS18420	COG3454	Phosphonate metabolism
D1823_RS18425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1823_RS18435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1823_RS18445	COG0071	Belongs to the small heat shock protein (HSP20) family
D1823_RS18455	COG0384	phenazine biosynthesis protein PhzF
D1823_RS18460	COG0747	negative chemotaxis
D1823_RS18465	COG0601	transmembrane transport
D1823_RS18470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1823_RS18475	COG0444	Belongs to the ABC transporter superfamily
D1823_RS18480	COG4608	Belongs to the ABC transporter superfamily
D1823_RS18500	COG0714	Associated with various cellular activities
D1823_RS18545	COG5002	protein histidine kinase activity
D1823_RS18580	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1823_RS18585	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D1823_RS18660	COG1116	anion transmembrane transporter activity
D1823_RS18665	COG0535	radical SAM domain protein
D1823_RS18670	COG0535	radical SAM domain protein
D1823_RS18675	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D1823_RS18680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D1823_RS18695	COG5002	protein histidine kinase activity
D1823_RS18710	COG0583	DNA-binding transcription factor activity
D1823_RS18720	COG1349	DNA-binding transcription factor activity
D1823_RS18735	COG1840	ABC-type Fe3 transport system, periplasmic component
D1823_RS18740	COG3842	ATPase activity
D1823_RS18755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1823_RS18765	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS18780	COG1522	sequence-specific DNA binding
D1823_RS18795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1823_RS18805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1823_RS18820	COG1609	Transcriptional regulator
D1823_RS18825	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS18835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1823_RS18885	COG1960	acyl-CoA dehydrogenase activity
D1823_RS18890	COG0436	Aminotransferase
D1823_RS18895	COG0583	DNA-binding transcription factor activity
D1823_RS18900	COG0583	DNA-binding transcription factor activity
D1823_RS18920	COG3327	negative regulation of DNA-templated transcription, initiation
D1823_RS18930	COG3396	Phenylacetate-CoA oxygenase
D1823_RS18935	COG3460	Phenylacetate-CoA oxygenase
D1823_RS18940	COG3396	Phenylacetate-CoA oxygenase
D1823_RS18945	COG2151	metal-sulfur cluster biosynthetic enzyme
D1823_RS18950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1823_RS18970	COG0735	belongs to the Fur family
D1823_RS18975	COG1121	(ABC) transporter
D1823_RS18980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1823_RS18990	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1823_RS18995	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1823_RS19000	COG3845	ABC transporter
D1823_RS19010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1823_RS19015	COG2080	2 iron, 2 sulfur cluster binding
D1823_RS19040	COG0124	histidyl-tRNA synthetase
D1823_RS19045	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D1823_RS19050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1823_RS19080	COG4989	oxidoreductase activity
D1823_RS19100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1823_RS19110	COG1858	cytochrome C peroxidase
D1823_RS19120	COG4717	serine-type aminopeptidase activity
D1823_RS19125	COG0420	3'-5' exonuclease activity
D1823_RS19140	COG0583	DNA-binding transcription factor activity
D1823_RS19145	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1823_RS19150	COG0697	spore germination
D1823_RS19165	COG0116	Belongs to the methyltransferase superfamily
D1823_RS19175	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1823_RS19180	COG1805	sodium ion transport
D1823_RS19190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1823_RS19200	COG2871	sodium ion transport
D1823_RS19205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1823_RS19210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1823_RS19215	COG0517	IMP dehydrogenase activity
D1823_RS19225	COG1477	protein flavinylation
D1823_RS19235	COG3119	arylsulfatase activity
D1823_RS19240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D1823_RS19250	COG0793	Belongs to the peptidase S41A family
D1823_RS19255	COG0477	Major facilitator Superfamily
D1823_RS19275	COG1266	CAAX protease self-immunity
D1823_RS19280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1823_RS19285	COG0285	dihydrofolate synthase activity
D1823_RS19290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1823_RS19300	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS19300	COG3347	Dehydrogenase
D1823_RS19305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1823_RS19310	COG1671	Belongs to the UPF0178 family
D1823_RS19320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D1823_RS19325	COG0679	Auxin Efflux Carrier
D1823_RS19350	COG1228	amidohydrolase
D1823_RS19355	COG2986	histidine ammonia-lyase
D1823_RS19365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1823_RS19370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1823_RS19375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1823_RS19385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1823_RS19395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1823_RS19410	COG2226	methyltransferase
D1823_RS19415	COG1349	DNA-binding transcription factor activity
D1823_RS19425	COG4175	Glycine betaine
D1823_RS19425	COG3448	diguanylate cyclase activity
D1823_RS19450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1823_RS19455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1823_RS19460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D1823_RS19480	COG2723	6-phospho-beta-galactosidase activity
D1823_RS19485	COG1609	Transcriptional regulator
D1823_RS19490	COG1653	transport
D1823_RS19495	COG1175	transmembrane transport
D1823_RS19500	COG0395	ABC-type sugar transport system, permease component
D1823_RS19505	COG0366	Alpha amylase catalytic
D1823_RS19510	COG3842	ATPase activity
D1823_RS19530	COG0765	amino acid transport
D1823_RS19545	COG3842	ATPase activity
D1823_RS19570	COG0800	Aldolase
D1823_RS19575	COG3734	2-keto-3-deoxy-galactonokinase
D1823_RS19580	COG1028	Short-chain dehydrogenase reductase Sdr
D1823_RS19585	COG0129	dihydroxy-acid dehydratase activity
D1823_RS19590	COG1486	melibiose metabolic process
D1823_RS19595	COG0395	ABC-type sugar transport system, permease component
D1823_RS19600	COG1175	transmembrane transport
D1823_RS19610	COG1414	Transcriptional regulator
D1823_RS19730	COG0582	viral genome integration into host DNA
D1823_RS19735	COG0402	S-adenosylhomocysteine deaminase activity
D1823_RS19750	COG3845	ABC transporter
D1823_RS19755	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1823_RS19760	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1823_RS19770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D1823_RS19775	COG2010	Cytochrome c
D1823_RS19780	COG3909	cytochrome
D1823_RS19790	COG0583	DNA-binding transcription factor activity
D1823_RS19800	COG0596	Alpha beta hydrolase
D1823_RS19805	COG0384	phenazine biosynthesis protein PhzF
D1823_RS19820	COG1609	Transcriptional regulator
D1823_RS19830	COG1175	transmembrane transport
D1823_RS19865	COG1802	Transcriptional regulator
D1823_RS19880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1823_RS19915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1823_RS19925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1823_RS19935	COG2183	response to ionizing radiation
D1823_RS19955	COG2358	TRAP transporter, solute receptor (TAXI family
D1823_RS19960	COG0583	DNA-binding transcription factor activity
D1823_RS19965	COG2205	protein histidine kinase activity
D1823_RS19965	COG0784	Response regulator, receiver
D1823_RS20055	COG3901	Regulator of nitric oxide reductase transcription
D1823_RS20055	COG0348	domain, Protein
D1823_RS20060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1823_RS20090	COG2207	Transcriptional regulator
D1823_RS20100	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1823_RS20100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1823_RS20105	COG4311	Sarcosine oxidase, delta subunit
D1823_RS20110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS20115	COG0303	'Molybdopterin
D1823_RS20135	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D1823_RS20145	COG1917	Cupin 2, conserved barrel domain protein
D1823_RS20150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1823_RS20160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1823_RS20175	COG1672	PFAM Archaeal ATPase
D1823_RS20175	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1823_RS20180	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D1823_RS20190	COG0156	8-amino-7-oxononanoate synthase activity
D1823_RS20200	COG1845	cytochrome c oxidase, subunit III
D1823_RS20210	COG0714	Associated with various cellular activities
D1823_RS20235	COG2010	Cytochrome c
D1823_RS20250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1823_RS20255	COG2010	Cytochrome c
D1823_RS20260	COG3391	amine dehydrogenase activity
D1823_RS20280	COG0535	radical SAM domain protein
D1823_RS20320	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D1823_RS20335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1823_RS20345	COG0243	molybdopterin cofactor binding
D1823_RS20350	COG0437	4 iron, 4 sulfur cluster binding
D1823_RS20355	COG0348	domain, Protein
D1823_RS20365	COG3005	denitrification pathway
D1823_RS20375	COG1349	DNA-binding transcription factor activity
D1823_RS20390	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1823_RS20390	COG1672	PFAM Archaeal ATPase
D1823_RS20410	COG0142	geranyltranstransferase activity
D1823_RS20430	COG1960	acyl-CoA dehydrogenase activity
D1823_RS20460	COG1115	amino acid carrier protein
D1823_RS20470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1823_RS20475	COG0509	glycine decarboxylation via glycine cleavage system
D1823_RS20480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1823_RS20480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1823_RS20495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1823_RS20505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D1823_RS20510	COG0045	succinate-CoA ligase (ADP-forming) activity
D1823_RS20520	COG2197	response regulator
D1823_RS20560	COG0310	cobalt ion transport
D1823_RS20570	COG1940	carbohydrate kinase activity
D1823_RS20590	COG1072	(Pantothenic acid kinase))
D1823_RS20605	COG0028	Belongs to the TPP enzyme family
D1823_RS20615	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS20625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1823_RS20635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1823_RS20635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1823_RS20650	COG1309	transcriptional regulator
D1823_RS20660	COG4638	Rieske (2fe-2S)
D1823_RS20665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1823_RS20675	COG2855	membrane
D1823_RS20680	COG0028	Belongs to the TPP enzyme family
D1823_RS20685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS20700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1823_RS20700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1823_RS20705	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1823_RS20705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1823_RS20710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1823_RS20725	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1823_RS20725	COG1902	pentaerythritol trinitrate reductase activity
D1823_RS20735	COG1522	sequence-specific DNA binding
D1823_RS20740	COG1473	amidohydrolase
D1823_RS20745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1823_RS20755	COG0826	peptidase U32
D1823_RS20760	COG0826	peptidase U32
D1823_RS20770	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1823_RS20775	COG0163	prenyltransferase activity
D1823_RS20790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1823_RS20800	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS20805	COG4242	Belongs to the peptidase S51 family
D1823_RS20810	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1823_RS20810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1823_RS20815	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1823_RS20815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1823_RS20820	COG1414	Transcriptional regulator
D1823_RS20860	COG3754	Rhamnan synthesis protein F
D1823_RS20865	COG3754	Rhamnan synthesis protein F
D1823_RS20885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D1823_RS20890	COG1091	dTDP-4-dehydrorhamnose reductase activity
D1823_RS20900	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D1823_RS20925	COG2274	protein secretion by the type I secretion system
D1823_RS20930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1823_RS20950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1823_RS20955	COG1127	ABC transporter
D1823_RS20970	COG0069	glutamate synthase activity
D1823_RS20975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1823_RS20980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1823_RS20985	COG2814	Major facilitator Superfamily
D1823_RS20990	COG1566	PFAM secretion protein HlyD family protein
D1823_RS21005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1823_RS21050	COG3119	arylsulfatase activity
D1823_RS21095	COG0811	peptide transport
D1823_RS21125	COG0673	inositol 2-dehydrogenase activity
D1823_RS21130	COG0395	ABC-type sugar transport system, permease component
D1823_RS21135	COG1175	transmembrane transport
D1823_RS21145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1823_RS21155	COG2188	Transcriptional regulator
D1823_RS21160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1823_RS21165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1823_RS21170	COG3257	ureidoglycine aminohydrolase activity
D1823_RS21175	COG1414	Transcriptional regulator
D1823_RS21180	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1823_RS21185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1823_RS21190	COG3616	Alanine racemase, N-terminal domain
D1823_RS21195	COG2423	ornithine cyclodeaminase activity
D1823_RS21205	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
D1823_RS21215	COG2351	hydroxyisourate hydrolase activity
D1823_RS21220	COG0583	DNA-binding transcription factor activity
D1823_RS21240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1823_RS21260	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
D1823_RS21265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1823_RS21280	COG0583	DNA-binding transcription factor activity
D1823_RS21285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1823_RS21295	COG0583	DNA-binding transcription factor activity
D1823_RS21320	COG1132	(ABC) transporter
D1823_RS21325	COG4608	Belongs to the ABC transporter superfamily
D1823_RS21330	COG0444	Belongs to the ABC transporter superfamily
D1823_RS21335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1823_RS21340	COG0601	transmembrane transport
D1823_RS21350	COG0747	negative chemotaxis
D1823_RS21355	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1823_RS21380	COG2030	dehydratase
D1823_RS21380	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS21405	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1823_RS21405	COG1024	Enoyl-CoA hydratase
D1823_RS21410	COG1024	Enoyl-CoA hydratase
D1823_RS21415	COG2050	protein possibly involved in aromatic compounds catabolism
D1823_RS21435	COG3971	2-oxopent-4-enoate hydratase activity
D1823_RS21440	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1823_RS21450	COG3384	dioxygenase
D1823_RS21455	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS21465	COG1846	Transcriptional regulator
D1823_RS21470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1823_RS21495	COG1012	belongs to the aldehyde dehydrogenase family
D1823_RS21500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1823_RS21505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D1823_RS21510	COG5441	Belongs to the UPF0261 family
D1823_RS21520	COG0640	Transcriptional regulator
D1823_RS21525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1823_RS21530	COG0765	amino acid transport
D1823_RS21535	COG0765	amino acid transport
D1823_RS21545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1823_RS21550	COG3938	Belongs to the proline racemase family
D1823_RS21555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1823_RS21560	COG4948	Mandelate Racemase Muconate Lactonizing
D1823_RS21565	COG3938	Belongs to the proline racemase family
D1823_RS21585	COG0318	PFAM AMP-dependent synthetase and ligase
D1823_RS21590	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D1823_RS21615	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1823_RS21620	COG0765	amino acid transport
D1823_RS21625	COG1126	abc transporter atp-binding protein
D1823_RS21685	COG1335	isochorismatase
D1823_RS21700	COG1349	DNA-binding transcription factor activity
D1823_RS21710	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D1823_RS21715	COG3639	organic phosphonate transmembrane transporter activity
D1823_RS21725	COG1011	Hydrolase
D1823_RS21740	COG0583	DNA-binding transcription factor activity
D1823_RS21745	COG0604	alcohol dehydrogenase
D1823_RS21745	COG3321	synthase
D1823_RS21755	COG4319	ketosteroid isomerase
D1823_RS21765	COG0583	DNA-binding transcription factor activity