locus-tag	class	description
AD2_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AD2_RS00010	COG0592	DNA-directed DNA polymerase activity
AD2_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AD2_RS00030	COG0187	DNA topoisomerase II activity
AD2_RS00035	COG1192	Involved in chromosome partitioning
AD2_RS00040	COG1475	DNA binding
AD2_RS00055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AD2_RS00070	COG2814	Major facilitator Superfamily
AD2_RS00080	COG2373	Large extracellular alpha-helical protein
AD2_RS00090	COG2720	vancomycin resistance protein
AD2_RS00110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AD2_RS00120	COG0674	pyruvate-flavodoxin oxidoreductase activity
AD2_RS00125	COG1013	pyruvate-flavodoxin oxidoreductase activity
AD2_RS00155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AD2_RS00175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AD2_RS00180	COG1802	Transcriptional regulator
AD2_RS00185	COG2608	mercury ion transmembrane transporter activity
AD2_RS00195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AD2_RS00220	COG4717	serine-type aminopeptidase activity
AD2_RS00225	COG0791	NLP P60 protein
AD2_RS00230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AD2_RS00245	COG2959	enzyme of heme biosynthesis
AD2_RS00270	COG1078	dGTPase activity
AD2_RS00305	COG3872	metal-dependent enzyme
AD2_RS00310	COG2890	protein-(glutamine-N5) methyltransferase activity
AD2_RS00320	COG4656	Part of a membrane complex involved in electron transport
AD2_RS00325	COG4658	electron transport chain
AD2_RS00330	COG4659	FMN binding
AD2_RS00335	COG4660	Part of a membrane complex involved in electron transport
AD2_RS00340	COG4657	Part of a membrane complex involved in electron transport
AD2_RS00345	COG2878	Part of a membrane complex involved in electron transport
AD2_RS00370	COG1349	DNA-binding transcription factor activity
AD2_RS00375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AD2_RS00380	COG3959	Transketolase, thiamine diphosphate binding domain
AD2_RS00385	COG3958	Transketolase
AD2_RS00390	COG1063	alcohol dehydrogenase
AD2_RS00395	COG1879	ABC-type sugar transport system periplasmic component
AD2_RS00400	COG1129	ABC transporter
AD2_RS00410	COG0406	alpha-ribazole phosphatase activity
AD2_RS00420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AD2_RS00425	COG1164	Oligoendopeptidase f
AD2_RS00435	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS00445	COG0590	tRNA wobble adenosine to inosine editing
AD2_RS00460	COG0662	Cupin 2, conserved barrel domain protein
AD2_RS00465	COG3584	3D domain protein
AD2_RS00470	COG1609	Transcriptional regulator
AD2_RS00495	COG0668	transmembrane transport
AD2_RS00505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AD2_RS00515	COG0590	tRNA wobble adenosine to inosine editing
AD2_RS00520	COG0028	Belongs to the TPP enzyme family
AD2_RS00525	COG0440	acetolactate synthase activity
AD2_RS00530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AD2_RS00535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AD2_RS00545	COG1191	sigma factor activity
AD2_RS00560	COG1959	2 iron, 2 sulfur cluster binding
AD2_RS00565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AD2_RS00575	COG0181	hydroxymethylbilane synthase activity
AD2_RS00585	COG0113	porphobilinogen synthase activity
AD2_RS00590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AD2_RS00595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AD2_RS00600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AD2_RS00605	COG4208	sulfate ABC transporter
AD2_RS00615	COG0175	sulfate reduction
AD2_RS00620	COG0175	sulfate reduction
AD2_RS00635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AD2_RS00660	COG1595	DNA-templated transcription, initiation
AD2_RS00690	COG3534	alpha-L-arabinofuranosidase
AD2_RS00695	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_RS00705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AD2_RS00715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AD2_RS00730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AD2_RS00735	COG1216	Glycosyl transferase, family 2
AD2_RS00740	COG1088	dTDP-glucose 4,6-dehydratase activity
AD2_RS00750	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AD2_RS00770	COG3328	transposase activity
AD2_RS00780	COG1032	radical SAM domain protein
AD2_RS00820	COG1116	anion transmembrane transporter activity
AD2_RS00825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_RS00830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AD2_RS00840	COG2954	triphosphatase activity
AD2_RS00860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AD2_RS00865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AD2_RS00870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AD2_RS00880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AD2_RS00880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AD2_RS00895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AD2_RS00905	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS00920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AD2_RS00925	COG0428	transporter
AD2_RS00930	COG0009	L-threonylcarbamoyladenylate synthase
AD2_RS00940	COG0698	ribose 5-phosphate isomerase
AD2_RS00945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AD2_RS00950	COG2131	deaminase
AD2_RS00955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AD2_RS00960	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AD2_RS00965	COG0356	it plays a direct role in the translocation of protons across the membrane
AD2_RS00970	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AD2_RS00975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AD2_RS00980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AD2_RS00985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AD2_RS00990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AD2_RS00995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AD2_RS01000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AD2_RS01020	COG3266	domain, Protein
AD2_RS01020	COG2911	Protein conserved in bacteria
AD2_RS01020	COG1361	Conserved repeat domain
AD2_RS01030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AD2_RS01035	COG2385	sporulation resulting in formation of a cellular spore
AD2_RS01045	COG1609	Transcriptional regulator
AD2_RS01055	COG4786	Flagellar basal body rod
AD2_RS01075	COG1136	(ABC) transporter
AD2_RS01075	COG0577	efflux transmembrane transporter activity
AD2_RS01080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AD2_RS01085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AD2_RS01090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AD2_RS01095	COG2088	sporulation resulting in formation of a cellular spore
AD2_RS01100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AD2_RS01110	COG0193	aminoacyl-tRNA hydrolase activity
AD2_RS01115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AD2_RS01120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AD2_RS01125	COG1917	Cupin 2, conserved barrel domain protein
AD2_RS01125	COG2207	Transcriptional regulator
AD2_RS01130	COG0259	pyridoxamine-phosphate oxidase activity
AD2_RS01135	COG0728	peptidoglycan biosynthetic process
AD2_RS01155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AD2_RS01160	COG2089	acid synthase
AD2_RS01170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AD2_RS01175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AD2_RS01180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AD2_RS01190	COG1181	Belongs to the D-alanine--D-alanine ligase family
AD2_RS01195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AD2_RS01225	COG4464	protein tyrosine phosphatase activity
AD2_RS01230	COG2002	toxin-antitoxin pair type II binding
AD2_RS01235	COG3956	TIGRFAM MazG family protein
AD2_RS01245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AD2_RS01265	COG1098	S1 RNA binding domain
AD2_RS01285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AD2_RS01360	COG3852	Histidine kinase
AD2_RS01375	COG0793	Belongs to the peptidase S41A family
AD2_RS01420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AD2_RS01425	COG0849	cell division
AD2_RS01430	COG1607	acyl-coa hydrolase
AD2_RS01435	COG2244	polysaccharide biosynthetic process
AD2_RS01440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AD2_RS01450	COG0110	maltose O-acetyltransferase activity
AD2_RS01475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AD2_RS01475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AD2_RS01480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AD2_RS01485	COG0864	Transcriptional regulator
AD2_RS01490	COG2337	Toxic component of a toxin-antitoxin (TA) module
AD2_RS01505	COG0438	transferase activity, transferring glycosyl groups
AD2_RS01510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AD2_RS01515	COG3959	Transketolase, thiamine diphosphate binding domain
AD2_RS01520	COG3958	Transketolase
AD2_RS01525	COG1131	(ABC) transporter
AD2_RS01545	COG3949	Membrane
AD2_RS01560	COG0129	dihydroxy-acid dehydratase activity
AD2_RS01565	COG0028	Belongs to the TPP enzyme family
AD2_RS01580	COG0250	Participates in transcription elongation, termination and antitermination
AD2_RS01585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AD2_RS01590	COG0081	regulation of translation
AD2_RS01595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AD2_RS01605	COG0085	RNA polymerase activity
AD2_RS01610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AD2_RS01615	COG1358	cellular component organization or biogenesis
AD2_RS01620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AD2_RS01625	COG0049	tRNA binding
AD2_RS01630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AD2_RS01635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AD2_RS01655	COG2720	vancomycin resistance protein
AD2_RS01665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AD2_RS01670	COG0322	excinuclease ABC activity
AD2_RS01680	COG0544	peptidyl-prolyl cis-trans isomerase activity
AD2_RS01685	COG0740	serine-type endopeptidase activity
AD2_RS01690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AD2_RS01695	COG1067	ATP-dependent peptidase activity
AD2_RS01695	COG0470	DNA polymerase III
AD2_RS01700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AD2_RS01705	COG0741	lytic transglycosylase activity
AD2_RS01720	COG0613	PHP domain protein
AD2_RS01725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AD2_RS01745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AD2_RS01765	COG3263	regulation of cellular component size
AD2_RS01770	COG2207	Transcriptional regulator
AD2_RS01770	COG3708	Transcriptional regulator
AD2_RS01775	COG4447	cellulose binding
AD2_RS01775	COG4733	cellulase activity
AD2_RS01780	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_RS01815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AD2_RS01820	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AD2_RS01830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AD2_RS01875	COG3266	domain, Protein
AD2_RS01875	COG1361	Conserved repeat domain
AD2_RS01875	COG2911	Protein conserved in bacteria
AD2_RS01880	COG5012	cobalamin binding
AD2_RS01885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AD2_RS01910	COG1116	anion transmembrane transporter activity
AD2_RS01915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_RS01920	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AD2_RS01925	COG0436	Aminotransferase
AD2_RS01930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AD2_RS01940	COG0674	pyruvate-flavodoxin oxidoreductase activity
AD2_RS01945	COG1013	pyruvate-flavodoxin oxidoreductase activity
AD2_RS01955	COG0251	oxidation-reduction process
AD2_RS01960	COG0626	cystathionine gamma-synthase activity
AD2_RS01965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AD2_RS01970	COG1151	hydroxylamine reductase activity
AD2_RS01980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_RS01985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AD2_RS01995	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_RS02000	COG1609	Transcriptional regulator
AD2_RS02015	COG4124	Belongs to the glycosyl hydrolase 26 family
AD2_RS02020	COG4447	cellulose binding
AD2_RS02020	COG4733	cellulase activity
AD2_RS02030	COG2205	protein histidine kinase activity
AD2_RS02040	COG0835	chemotaxis
AD2_RS02045	COG2198	Histidine kinase
AD2_RS02045	COG0784	Response regulator, receiver
AD2_RS02045	COG0643	Histidine kinase
AD2_RS02055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AD2_RS02060	COG2201	protein-glutamate methylesterase activity
AD2_RS02070	COG1253	flavin adenine dinucleotide binding
AD2_RS02080	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_RS02090	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AD2_RS02120	COG0124	histidyl-tRNA synthetase
AD2_RS02125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AD2_RS02130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AD2_RS02135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AD2_RS02140	COG0131	Imidazoleglycerol-phosphate dehydratase
AD2_RS02145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AD2_RS02150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AD2_RS02155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AD2_RS02160	COG0107	imidazoleglycerol-phosphate synthase activity
AD2_RS02175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AD2_RS02180	COG0459	protein refolding
AD2_RS02195	COG3858	chitin binding
AD2_RS02205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AD2_RS02210	COG1366	Belongs to the anti-sigma-factor antagonist family
AD2_RS02220	COG1191	sigma factor activity
AD2_RS02250	COG0051	transcription antitermination factor activity, RNA binding
AD2_RS02255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AD2_RS02260	COG0088	Forms part of the polypeptide exit tunnel
AD2_RS02265	COG0089	rRNA binding
AD2_RS02270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AD2_RS02275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AD2_RS02280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AD2_RS02285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AD2_RS02290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AD2_RS02295	COG0255	Belongs to the universal ribosomal protein uL29 family
AD2_RS02300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AD2_RS02305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AD2_RS02310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AD2_RS02315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AD2_RS02320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AD2_RS02325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AD2_RS02330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AD2_RS02335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AD2_RS02340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AD2_RS02345	COG1841	ribosomal large subunit assembly
AD2_RS02350	COG0200	Binds to the 23S rRNA
AD2_RS02355	COG0201	protein transport
AD2_RS02360	COG0563	adenylate kinase activity
AD2_RS02375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AD2_RS02380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AD2_RS02385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AD2_RS02390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AD2_RS02395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AD2_RS02400	COG0202	RNA polymerase activity
AD2_RS02405	COG0203	ribosomal protein L17
AD2_RS02410	COG1122	ATPase activity
AD2_RS02415	COG2813	Specifically methylates the guanine in position
AD2_RS02460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AD2_RS02465	COG1122	ATPase activity
AD2_RS02470	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AD2_RS02475	COG1940	carbohydrate kinase activity
AD2_RS02480	COG0101	tRNA pseudouridine synthase activity
AD2_RS02485	COG1329	Transcriptional regulator
AD2_RS02490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AD2_RS02495	COG4555	ABC transporter
AD2_RS02500	COG1668	transmembrane transport
AD2_RS02505	COG4191	Histidine kinase
AD2_RS02505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AD2_RS02510	COG3290	protein histidine kinase activity
AD2_RS02515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AD2_RS02520	COG0442	prolyl-tRNA aminoacylation
AD2_RS02525	COG2340	Cysteine-rich secretory protein family
AD2_RS02530	COG2273	Hydrolase Family 16
AD2_RS02535	COG3250	beta-galactosidase activity
AD2_RS02605	COG4166	transmembrane transport
AD2_RS02610	COG4608	Belongs to the ABC transporter superfamily
AD2_RS02615	COG0444	Belongs to the ABC transporter superfamily
AD2_RS02620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AD2_RS02625	COG0601	transmembrane transport
AD2_RS02650	COG1725	Transcriptional regulator
AD2_RS02655	COG1131	(ABC) transporter
AD2_RS02675	COG1489	DNA binding
AD2_RS02680	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AD2_RS02685	COG1191	sigma factor activity
AD2_RS02725	COG0840	transmembrane signaling receptor activity
AD2_RS02775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AD2_RS02805	COG0693	protein deglycase activity
AD2_RS02815	COG1132	(ABC) transporter
AD2_RS02825	COG0306	phosphate transporter
AD2_RS02845	COG1388	LysM domain
AD2_RS02850	COG1376	ErfK ybiS ycfS ynhG family protein
AD2_RS02880	COG5520	Belongs to the glycosyl hydrolase 30 family
AD2_RS02890	COG0409	Hydrogenase expression formation protein
AD2_RS02900	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AD2_RS02915	COG3261	NADH dehydrogenase
AD2_RS02915	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AD2_RS02925	COG3260	NADH ubiquinone oxidoreductase 20
AD2_RS02935	COG2111	Na H antiporter
AD2_RS02935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AD2_RS02940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AD2_RS02945	COG0372	Belongs to the citrate synthase family
AD2_RS02950	COG0076	glutamate decarboxylase activity
AD2_RS02955	COG0835	chemotaxis
AD2_RS02960	COG0840	transmembrane signaling receptor activity
AD2_RS02985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AD2_RS02990	COG0840	transmembrane signaling receptor activity
AD2_RS03025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AD2_RS03045	COG0768	penicillin binding
AD2_RS03050	COG2003	Belongs to the UPF0758 family
AD2_RS03065	COG3328	transposase activity
AD2_RS03110	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AD2_RS03130	COG3458	cephalosporin-C deacetylase activity
AD2_RS03160	COG1131	(ABC) transporter
AD2_RS03170	COG5002	protein histidine kinase activity
AD2_RS03175	COG0745	RESPONSE REGULATOR receiver
AD2_RS03190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AD2_RS03195	COG0561	phosphatase activity
AD2_RS03200	COG2304	oxidoreductase activity
AD2_RS03210	COG2911	Protein conserved in bacteria
AD2_RS03215	COG2911	Protein conserved in bacteria
AD2_RS03215	COG3266	domain, Protein
AD2_RS03215	COG1361	Conserved repeat domain
AD2_RS03220	COG1361	Conserved repeat domain
AD2_RS03225	COG1361	Conserved repeat domain
AD2_RS03245	COG0116	Belongs to the methyltransferase superfamily
AD2_RS03255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AD2_RS03275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AD2_RS03290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AD2_RS03325	COG0463	Glycosyl transferase, family 2
AD2_RS03340	COG0463	Glycosyl transferase, family 2
AD2_RS03350	COG1216	Glycosyl transferase, family 2
AD2_RS03355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AD2_RS03360	COG0436	Aminotransferase
AD2_RS03365	COG1316	TRANSCRIPTIONal
AD2_RS03380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AD2_RS03385	COG0720	synthase
AD2_RS03390	COG0602	queuosine metabolic process
AD2_RS03395	COG1573	uracil-dna glycosylase
AD2_RS03400	COG1573	uracil-dna glycosylase
AD2_RS03430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AD2_RS03445	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AD2_RS03450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AD2_RS03465	COG1482	cell wall glycoprotein biosynthetic process
AD2_RS03475	COG2703	oxygen carrier activity
AD2_RS03480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AD2_RS03480	COG1773	rubredoxin
AD2_RS03495	COG1361	Conserved repeat domain
AD2_RS03505	COG0318	PFAM AMP-dependent synthetase and ligase
AD2_RS03515	COG1056	cytidyltransferase-related domain
AD2_RS03515	COG1051	belongs to the nudix hydrolase family
AD2_RS03530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AD2_RS03545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_RS03550	COG2267	carboxylic ester hydrolase activity
AD2_RS03565	COG1404	Belongs to the peptidase S8 family
AD2_RS03585	COG3401	FG-GAP repeat protein
AD2_RS03585	COG2755	lipolytic protein G-D-S-L family
AD2_RS03600	COG2207	Transcriptional regulator
AD2_RS03600	COG3708	Transcriptional regulator
AD2_RS03615	COG1132	(ABC) transporter
AD2_RS03620	COG1132	(ABC) transporter
AD2_RS03625	COG2195	Cleaves the N-terminal amino acid of tripeptides
AD2_RS03640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AD2_RS03660	COG0840	transmembrane signaling receptor activity
AD2_RS03665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AD2_RS03670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AD2_RS03675	COG1802	Transcriptional regulator
AD2_RS03680	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AD2_RS03680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AD2_RS03685	COG1187	pseudouridine synthase activity
AD2_RS03710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AD2_RS03715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AD2_RS03720	COG1597	lipid kinase activity
AD2_RS03730	COG1136	(ABC) transporter
AD2_RS03740	COG0577	efflux transmembrane transporter activity
AD2_RS03740	COG1136	(ABC) transporter
AD2_RS03760	COG2323	membrane
AD2_RS03780	COG1686	Belongs to the peptidase S11 family
AD2_RS03790	COG0569	domain protein
AD2_RS03825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AD2_RS03870	COG0628	permease
AD2_RS03875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AD2_RS03960	COG3328	transposase activity
AD2_RS04040	COG3328	transposase activity
AD2_RS04065	COG3328	transposase activity
AD2_RS04070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AD2_RS04070	COG0723	plastoquinol--plastocyanin reductase activity
AD2_RS04090	COG1126	abc transporter atp-binding protein
AD2_RS04140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AD2_RS04180	COG1595	DNA-templated transcription, initiation
AD2_RS04205	COG1028	Short-chain dehydrogenase reductase Sdr
AD2_RS04240	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AD2_RS04245	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AD2_RS04255	COG0628	permease
AD2_RS04265	COG1714	RDD family
AD2_RS04270	COG0616	signal peptide processing
AD2_RS04275	COG1971	Probably functions as a manganese efflux pump
AD2_RS04290	COG1131	(ABC) transporter
AD2_RS04305	COG0133	tryptophan synthase activity
AD2_RS04310	COG0159	tryptophan synthase activity
AD2_RS04315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AD2_RS04320	COG5002	protein histidine kinase activity
AD2_RS04325	COG0745	RESPONSE REGULATOR receiver
AD2_RS04340	COG5337	Spore coat protein CotH
AD2_RS04345	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AD2_RS04355	COG1321	iron dependent repressor
AD2_RS04375	COG4447	cellulose binding
AD2_RS04380	COG1442	glycosyl transferase family 8
AD2_RS04385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AD2_RS04390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AD2_RS04395	COG0745	RESPONSE REGULATOR receiver
AD2_RS04400	COG5002	protein histidine kinase activity
AD2_RS04405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AD2_RS04410	COG2267	carboxylic ester hydrolase activity
AD2_RS04415	COG0617	tRNA 3'-terminal CCA addition
AD2_RS04425	COG4496	protein, YerC YecD
AD2_RS04440	COG0653	protein targeting
AD2_RS04445	COG0285	dihydrofolate synthase activity
AD2_RS04455	COG1752	Esterase of the alpha-beta hydrolase superfamily
AD2_RS04465	COG2201	protein-glutamate methylesterase activity
AD2_RS04470	COG0673	inositol 2-dehydrogenase activity
AD2_RS04475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_RS04475	COG2199	diguanylate cyclase activity
AD2_RS04480	COG4492	Belongs to the UPF0735 family
AD2_RS04485	COG0460	homoserine dehydrogenase
AD2_RS04490	COG0527	aspartate kinase activity
AD2_RS04535	COG0537	adenosine 5'-monophosphoramidase activity
AD2_RS04540	COG1361	Conserved repeat domain
AD2_RS04550	COG4464	protein tyrosine phosphatase activity
AD2_RS04570	COG0489	protein tyrosine kinase activity
AD2_RS04610	COG1216	Glycosyl transferase, family 2
AD2_RS04625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AD2_RS04635	COG0629	single-stranded DNA binding
AD2_RS04640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AD2_RS04645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AD2_RS04655	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AD2_RS04655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AD2_RS04660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AD2_RS04665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AD2_RS04670	COG1490	D-aminoacyl-tRNA deacylase activity
AD2_RS04675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AD2_RS04680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AD2_RS04730	COG0124	histidyl-tRNA synthetase
AD2_RS04735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AD2_RS04765	COG0481	GTPase activity
AD2_RS04770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AD2_RS04775	COG1420	regulation of RNA biosynthetic process
AD2_RS04780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AD2_RS04785	COG0443	Heat shock 70 kDa protein
AD2_RS04790	COG0484	heat shock protein binding
AD2_RS04795	COG2264	protein methyltransferase activity
AD2_RS04800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AD2_RS04805	COG2201	protein-glutamate methylesterase activity
AD2_RS04815	COG1561	YicC-like family, N-terminal region
AD2_RS04820	COG2052	Domain of unknown function (DUF370)
AD2_RS04825	COG0194	GDP metabolic process
AD2_RS04830	COG1758	RNA polymerase activity
AD2_RS04835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AD2_RS04840	COG0423	glycine-tRNA ligase activity
AD2_RS04845	COG3290	protein histidine kinase activity
AD2_RS04855	COG0535	radical SAM domain protein
AD2_RS04860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AD2_RS04860	COG0574	Belongs to the PEP-utilizing enzyme family
AD2_RS04865	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS04880	COG0662	Cupin 2, conserved barrel domain protein
AD2_RS04885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AD2_RS04895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AD2_RS04900	COG1323	Belongs to the UPF0348 family
AD2_RS04920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AD2_RS04930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AD2_RS04945	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AD2_RS04965	COG0745	RESPONSE REGULATOR receiver
AD2_RS04970	COG5002	protein histidine kinase activity
AD2_RS04970	COG3850	Histidine kinase
AD2_RS04975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AD2_RS04980	COG2199	diguanylate cyclase activity
AD2_RS04980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_RS04985	COG0297	glycogen (starch) synthase activity
AD2_RS04990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AD2_RS05010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AD2_RS05015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AD2_RS05020	COG0742	ribosomal rna small subunit methyltransferase
AD2_RS05025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AD2_RS05035	COG3314	Sporulation integral membrane protein YlbJ
AD2_RS05040	COG2755	lipolytic protein G-D-S-L family
AD2_RS05045	COG1191	sigma factor activity
AD2_RS05050	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS05070	COG2197	response regulator
AD2_RS05075	COG0840	transmembrane signaling receptor activity
AD2_RS05080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AD2_RS05100	COG0205	6-phosphofructokinase activity
AD2_RS05125	COG1472	Belongs to the glycosyl hydrolase 3 family
AD2_RS05145	COG2252	PERMEase
AD2_RS05150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AD2_RS05155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AD2_RS05160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AD2_RS05165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AD2_RS05170	COG0138	bifunctional purine biosynthesis protein purh
AD2_RS05175	COG0151	Belongs to the GarS family
AD2_RS05180	COG1216	Glycosyl transferase, family 2
AD2_RS05190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AD2_RS05195	COG1713	HD superfamily hydrolase involved in NAD metabolism
AD2_RS05205	COG0799	negative regulation of ribosome biogenesis
AD2_RS05210	COG0495	leucyl-tRNA aminoacylation
AD2_RS05220	COG0840	transmembrane signaling receptor activity
AD2_RS05230	COG1022	Amp-dependent synthetase and ligase
AD2_RS05235	COG1686	Belongs to the peptidase S11 family
AD2_RS05240	COG1596	polysaccharide export
AD2_RS05240	COG1555	photosystem II stabilization
AD2_RS05250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AD2_RS05265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AD2_RS05270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AD2_RS05275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AD2_RS05280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AD2_RS05285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AD2_RS05290	COG3459	Glycosyltransferase 36 associated
AD2_RS05305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AD2_RS05310	COG0542	response to heat
AD2_RS05315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AD2_RS05320	COG0730	response to heat
AD2_RS05340	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AD2_RS05365	COG2766	serine protein kinase
AD2_RS05370	COG2718	Belongs to the UPF0229 family
AD2_RS05375	COG2719	SpoVR family
AD2_RS05390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AD2_RS05395	COG0402	S-adenosylhomocysteine deaminase activity
AD2_RS05435	COG3328	transposase activity
AD2_RS05445	COG0546	phosphoglycolate phosphatase activity
AD2_RS05455	COG4555	ABC transporter
AD2_RS05470	COG0657	acetylesterase activity
AD2_RS05485	COG0714	Associated with various cellular activities
AD2_RS05495	COG1305	Transglutaminase-like
AD2_RS05515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AD2_RS05520	COG1406	Chemotaxis phosphatase CheX
AD2_RS05550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AD2_RS05560	COG3885	ferrous iron binding
AD2_RS05560	COG2078	PFAM AMMECR1 domain protein
AD2_RS05570	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AD2_RS05580	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AD2_RS05585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AD2_RS05590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AD2_RS05595	COG0640	Transcriptional regulator
AD2_RS05600	COG0798	PFAM Bile acid sodium symporter
AD2_RS05630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AD2_RS05640	COG1459	type II secretion system
AD2_RS05680	COG0740	serine-type endopeptidase activity
AD2_RS05690	COG1674	ftsk spoiiie
AD2_RS05700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AD2_RS05710	COG1418	mRNA catabolic process
AD2_RS05715	COG1692	metallophosphoesterase
AD2_RS05720	COG2359	stage V sporulation protein S
AD2_RS05740	COG0438	transferase activity, transferring glycosyl groups
AD2_RS05750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AD2_RS05770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AD2_RS05790	COG3879	Bacterial protein of unknown function (DUF881)
AD2_RS05810	COG1702	phosphate starvation-inducible protein PhoH
AD2_RS05815	COG1480	7TM receptor with intracellular HD hydrolase
AD2_RS05820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AD2_RS05825	COG0295	cytidine deaminase activity
AD2_RS05830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AD2_RS05835	COG1381	Involved in DNA repair and RecF pathway recombination
AD2_RS05845	COG1104	cysteine desulfurase activity
AD2_RS05850	COG0301	tRNA thio-modification
AD2_RS05855	COG2720	vancomycin resistance protein
AD2_RS05870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AD2_RS05875	COG1983	PspC domain protein
AD2_RS05880	COG1305	Transglutaminase-like
AD2_RS05890	COG0714	Associated with various cellular activities
AD2_RS05895	COG0039	L-malate dehydrogenase activity
AD2_RS05900	COG1058	Belongs to the CinA family
AD2_RS05900	COG1546	Belongs to the CinA family
AD2_RS05905	COG0728	peptidoglycan biosynthetic process
AD2_RS05910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AD2_RS05920	COG0705	Rhomboid family
AD2_RS05920	COG0457	Tetratricopeptide repeat
AD2_RS05965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AD2_RS05985	COG1466	dna polymerase III delta subunit
AD2_RS05990	COG0268	Binds directly to 16S ribosomal RNA
AD2_RS06010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AD2_RS06020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AD2_RS06025	COG0154	amidase activity
AD2_RS06030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AD2_RS06040	COG0280	phosphate acetyltransferase
AD2_RS06045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AD2_RS06055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AD2_RS06065	COG1160	GTP binding
AD2_RS06075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AD2_RS06080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AD2_RS06090	COG1175	transmembrane transport
AD2_RS06095	COG0395	ABC-type sugar transport system, permease component
AD2_RS06105	COG2247	cell wall binding repeat
AD2_RS06105	COG0860	N-Acetylmuramoyl-L-alanine amidase
AD2_RS06120	COG1193	negative regulation of DNA recombination
AD2_RS06125	COG0628	permease
AD2_RS06135	COG0768	penicillin binding
AD2_RS06140	COG0826	peptidase U32
AD2_RS06145	COG4122	O-methyltransferase activity
AD2_RS06150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AD2_RS06155	COG1217	gtp-binding protein TYPA
AD2_RS06160	COG0052	Belongs to the universal ribosomal protein uS2 family
AD2_RS06165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AD2_RS06170	COG0528	UMP kinase activity
AD2_RS06175	COG0233	cytoplasmic translational termination
AD2_RS06185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AD2_RS06190	COG0575	Belongs to the CDS family
AD2_RS06195	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AD2_RS06205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AD2_RS06215	COG0779	Required for maturation of 30S ribosomal subunits
AD2_RS06220	COG0195	Participates in both transcription termination and antitermination
AD2_RS06225	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AD2_RS06235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AD2_RS06240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AD2_RS06245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AD2_RS06250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AD2_RS06255	COG0196	riboflavin kinase activity
AD2_RS06260	COG0612	Peptidase, M16
AD2_RS06265	COG0612	Peptidase, M16
AD2_RS06270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AD2_RS06275	COG0772	Belongs to the SEDS family
AD2_RS06280	COG2001	Belongs to the MraZ family
AD2_RS06285	COG0275	rRNA processing
AD2_RS06295	COG0768	penicillin binding
AD2_RS06300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AD2_RS06305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AD2_RS06310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AD2_RS06315	COG0772	Belongs to the SEDS family
AD2_RS06320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AD2_RS06325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AD2_RS06340	COG3328	transposase activity
AD2_RS06365	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AD2_RS06375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AD2_RS06380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AD2_RS06385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AD2_RS06390	COG2385	sporulation resulting in formation of a cellular spore
AD2_RS06390	COG2247	cell wall binding repeat
AD2_RS06395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AD2_RS06400	COG0343	queuine tRNA-ribosyltransferase activity
AD2_RS06405	COG1862	Preprotein translocase
AD2_RS06420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AD2_RS06430	COG0540	Belongs to the ATCase OTCase family
AD2_RS06435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AD2_RS06450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AD2_RS06455	COG0543	2 iron, 2 sulfur cluster binding
AD2_RS06460	COG0167	dihydroorotate dehydrogenase activity
AD2_RS06465	COG0588	phosphoglycerate mutase activity
AD2_RS06485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AD2_RS06490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AD2_RS06505	COG2030	dehydratase
AD2_RS06510	COG0416	fatty acid biosynthetic process
AD2_RS06515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AD2_RS06520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AD2_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
AD2_RS06530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AD2_RS06535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AD2_RS06540	COG0571	ribonuclease III activity
AD2_RS06550	COG2359	stage V sporulation protein S
AD2_RS06565	COG0552	protein localization to endoplasmic reticulum
AD2_RS06585	COG1748	Saccharopine dehydrogenase
AD2_RS06620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AD2_RS06645	COG1496	oxidoreductase activity
AD2_RS06655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AD2_RS06660	COG0564	pseudouridine synthase activity
AD2_RS06675	COG1418	mRNA catabolic process
AD2_RS06680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AD2_RS06685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AD2_RS06690	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AD2_RS06695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AD2_RS06700	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AD2_RS06715	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AD2_RS06720	COG0358	DNA primase activity
AD2_RS06725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AD2_RS06745	COG2384	SAM-dependent methyltransferase
AD2_RS06750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AD2_RS06760	COG3437	response regulator, receiver
AD2_RS06765	COG1595	DNA-templated transcription, initiation
AD2_RS06785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AD2_RS06785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AD2_RS06790	COG0237	dephospho-CoA kinase activity
AD2_RS06805	COG0697	spore germination
AD2_RS06815	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AD2_RS06820	COG0835	chemotaxis
AD2_RS06825	COG0012	GTP binding
AD2_RS06840	COG0512	Glutamine amidotransferase of anthranilate synthase
AD2_RS06840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AD2_RS06845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AD2_RS06850	COG0134	indole-3-glycerol-phosphate synthase activity
AD2_RS06855	COG0135	phosphoribosylanthranilate isomerase activity
AD2_RS06905	COG1316	TRANSCRIPTIONal
AD2_RS06910	COG1592	Rubrerythrin
AD2_RS06920	COG4864	UPF0365 protein
AD2_RS06925	COG1030	water channel activity
AD2_RS06930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AD2_RS06935	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AD2_RS06940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AD2_RS06945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AD2_RS06950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AD2_RS06960	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AD2_RS06965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AD2_RS06970	COG0006	proline dipeptidase activity
AD2_RS06975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AD2_RS06990	COG3854	ATPases associated with a variety of cellular activities
AD2_RS07030	COG1302	Protein conserved in bacteria
AD2_RS07045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AD2_RS07050	COG1570	exodeoxyribonuclease VII activity
AD2_RS07055	COG1722	exodeoxyribonuclease VII activity
AD2_RS07065	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AD2_RS07075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AD2_RS07080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AD2_RS07090	COG3291	Pkd domain containing protein
AD2_RS07115	COG1131	(ABC) transporter
AD2_RS07125	COG3706	GGDEF domain
AD2_RS07130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AD2_RS07135	COG1438	arginine binding
AD2_RS07140	COG0497	DNA recombination
AD2_RS07145	COG0750	zinc metalloprotease
AD2_RS07150	COG0745	RESPONSE REGULATOR receiver
AD2_RS07155	COG2201	protein-glutamate methylesterase activity
AD2_RS07160	COG0643	Histidine kinase
AD2_RS07160	COG2198	Histidine kinase
AD2_RS07165	COG0835	chemotaxis
AD2_RS07175	COG2201	protein-glutamate methylesterase activity
AD2_RS07185	COG0745	RESPONSE REGULATOR receiver
AD2_RS07195	COG0564	pseudouridine synthase activity
AD2_RS07205	COG3328	transposase activity
AD2_RS07210	COG5002	protein histidine kinase activity
AD2_RS07215	COG0745	RESPONSE REGULATOR receiver
AD2_RS07225	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_RS07225	COG2755	lipolytic protein G-D-S-L family
AD2_RS07235	COG0366	Alpha amylase catalytic
AD2_RS07240	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AD2_RS07250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AD2_RS07255	COG1799	cell septum assembly
AD2_RS07265	COG2302	S4 RNA-binding domain
AD2_RS07270	COG3599	regulation of cell shape
AD2_RS07280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AD2_RS07295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AD2_RS07305	COG0840	transmembrane signaling receptor activity
AD2_RS07315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AD2_RS07320	COG2340	Cysteine-rich secretory protein family
AD2_RS07330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AD2_RS07335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AD2_RS07340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AD2_RS07345	COG1923	regulation of RNA biosynthetic process
AD2_RS07350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AD2_RS07360	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AD2_RS07365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AD2_RS07370	COG0228	four-way junction DNA binding
AD2_RS07375	COG1837	Belongs to the UPF0109 family
AD2_RS07380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AD2_RS07385	COG0336	Belongs to the RNA methyltransferase TrmD family
AD2_RS07390	COG0335	large ribosomal subunit rRNA binding
AD2_RS07410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AD2_RS07425	COG0792	nuclease activity
AD2_RS07430	COG2003	Belongs to the UPF0758 family
AD2_RS07465	COG3842	ATPase activity
AD2_RS07470	COG1176	ABC-type spermidine putrescine transport system, permease component I
AD2_RS07490	COG4733	cellulase activity
AD2_RS07495	COG3409	Peptidoglycan-binding domain 1 protein
AD2_RS07495	COG0793	Belongs to the peptidase S41A family
AD2_RS07500	COG0534	Mate efflux family protein
AD2_RS07510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AD2_RS07515	COG2188	Transcriptional regulator
AD2_RS07535	COG1361	Conserved repeat domain
AD2_RS07535	COG3266	domain, Protein
AD2_RS07535	COG2911	Protein conserved in bacteria
AD2_RS07540	COG2911	Protein conserved in bacteria
AD2_RS07540	COG3266	domain, Protein
AD2_RS07540	COG1361	Conserved repeat domain
AD2_RS07555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AD2_RS07570	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_RS07575	COG4974	Belongs to the 'phage' integrase family
AD2_RS07585	COG1362	aminopeptidase activity
AD2_RS07590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_RS07590	COG2199	diguanylate cyclase activity
AD2_RS07595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AD2_RS07600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AD2_RS07605	COG0482	sulfurtransferase activity
AD2_RS07610	COG0822	iron-sulfur transferase activity
AD2_RS07620	COG1959	2 iron, 2 sulfur cluster binding
AD2_RS07630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AD2_RS07635	COG0105	UTP biosynthetic process
AD2_RS07640	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AD2_RS07645	COG0539	negative regulation of cytoplasmic translation
AD2_RS07645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AD2_RS07650	COG0204	Acyl-transferase
AD2_RS07675	COG2081	HI0933 family
AD2_RS07680	COG0406	alpha-ribazole phosphatase activity
AD2_RS07685	COG1737	Transcriptional regulator
AD2_RS07710	COG0511	ligase activity, forming carbon-carbon bonds
AD2_RS07720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AD2_RS07730	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AD2_RS07735	COG0010	Belongs to the arginase family
AD2_RS07740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AD2_RS07745	COG1187	pseudouridine synthase activity
AD2_RS07750	COG3874	Sporulation protein YtfJ
AD2_RS07765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AD2_RS07770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AD2_RS07775	COG0180	Tryptophanyl-tRNA synthetase
AD2_RS07780	COG1994	Peptidase M50
AD2_RS07785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AD2_RS07785	COG0617	tRNA 3'-terminal CCA addition
AD2_RS07785	COG3620	sequence-specific DNA binding
AD2_RS07800	COG0517	IMP dehydrogenase activity
AD2_RS07800	COG0516	GMP reductase activity
AD2_RS07810	COG1686	Belongs to the peptidase S11 family
AD2_RS07820	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AD2_RS07825	COG4974	Belongs to the 'phage' integrase family
AD2_RS07830	COG1300	Membrane
AD2_RS07840	COG0328	RNA-DNA hybrid ribonuclease activity
AD2_RS07845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AD2_RS07875	COG0697	spore germination
AD2_RS07880	COG0330	HflC and HflK could
AD2_RS07890	COG3583	domain protein
AD2_RS07890	COG3584	3D domain protein
AD2_RS07910	COG2273	Hydrolase Family 16
AD2_RS07915	COG4447	cellulose binding
AD2_RS07940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AD2_RS07955	COG1942	4-Oxalocrotonate Tautomerase
AD2_RS07985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AD2_RS08010	COG3949	Membrane
AD2_RS08030	COG2273	Hydrolase Family 16
AD2_RS08035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AD2_RS08055	COG0631	protein serine/threonine phosphatase activity
AD2_RS08060	COG2815	serine threonine protein kinase
AD2_RS08060	COG0515	serine threonine protein kinase
AD2_RS08110	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_RS08120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AD2_RS08125	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AD2_RS08130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AD2_RS08135	COG1321	iron dependent repressor
AD2_RS08145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AD2_RS08145	COG1918	ferrous iron import across plasma membrane
AD2_RS08150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AD2_RS08170	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AD2_RS08180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AD2_RS08185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AD2_RS08210	COG0791	NLP P60 protein
AD2_RS08225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AD2_RS08230	COG0352	thiamine-phosphate diphosphorylase activity
AD2_RS08240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AD2_RS08245	COG2022	thiamine diphosphate biosynthetic process
AD2_RS08250	COG2104	thiamine diphosphate biosynthetic process
AD2_RS08250	COG2022	thiamine diphosphate biosynthetic process
AD2_RS08255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AD2_RS08275	COG2226	methyltransferase
AD2_RS08310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AD2_RS08320	COG1201	RNA secondary structure unwinding
AD2_RS08375	COG2204	response regulator
AD2_RS08385	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AD2_RS08390	COG0436	Aminotransferase
AD2_RS08395	COG0778	Nitroreductase
AD2_RS08410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AD2_RS08415	COG1162	GTPase activity
AD2_RS08420	COG0515	serine threonine protein kinase
AD2_RS08420	COG2815	serine threonine protein kinase
AD2_RS08425	COG0631	protein serine/threonine phosphatase activity
AD2_RS08430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AD2_RS08435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AD2_RS08435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AD2_RS08440	COG2738	Putative neutral zinc metallopeptidase
AD2_RS08450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AD2_RS08455	COG0242	peptide deformylase activity
AD2_RS08460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AD2_RS08485	COG1477	protein flavinylation
AD2_RS08490	COG1252	NADH dehydrogenase
AD2_RS08505	COG0726	polysaccharide deacetylase
AD2_RS08510	COG0367	asparagine synthase
AD2_RS08515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AD2_RS08520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AD2_RS08525	COG0583	DNA-binding transcription factor activity
AD2_RS08535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AD2_RS08545	COG0326	Molecular chaperone. Has ATPase activity
AD2_RS08550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AD2_RS08555	COG1121	(ABC) transporter
AD2_RS08560	COG0803	Belongs to the bacterial solute-binding protein 9 family
AD2_RS08565	COG0735	belongs to the Fur family
AD2_RS08575	COG0631	protein serine/threonine phosphatase activity
AD2_RS08580	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_RS08595	COG1136	(ABC) transporter
AD2_RS08595	COG0577	efflux transmembrane transporter activity
AD2_RS08600	COG1136	(ABC) transporter
AD2_RS08605	COG5002	protein histidine kinase activity
AD2_RS08605	COG3850	Histidine kinase
AD2_RS08610	COG0745	RESPONSE REGULATOR receiver
AD2_RS08615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_RS08615	COG4447	cellulose binding
AD2_RS08625	COG2274	protein secretion by the type I secretion system
AD2_RS08680	COG5002	protein histidine kinase activity
AD2_RS08685	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AD2_RS08700	COG2176	DNA-directed DNA polymerase activity
AD2_RS08705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AD2_RS08715	COG2843	Capsule synthesis protein
AD2_RS08750	COG1191	sigma factor activity
AD2_RS08760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AD2_RS08765	COG1776	CheC inhibitor of MCP methylation
AD2_RS08770	COG0835	chemotaxis
AD2_RS08775	COG2198	Histidine kinase
AD2_RS08775	COG0643	Histidine kinase
AD2_RS08780	COG2201	protein-glutamate methylesterase activity
AD2_RS08795	COG1419	protein localization to endoplasmic reticulum
AD2_RS08800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AD2_RS08805	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AD2_RS08810	COG1684	flagellar biosynthetic protein fliR
AD2_RS08815	COG1987	bacterial-type flagellum assembly
AD2_RS08820	COG1338	Plays a role in the flagellum-specific transport system
AD2_RS08830	COG2201	protein-glutamate methylesterase activity
AD2_RS08840	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AD2_RS08850	COG1582	Flagellar protein (FlbD)
AD2_RS08865	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AD2_RS08885	COG1157	protein secretion by the type III secretion system
AD2_RS08890	COG1317	bacterial-type flagellum organization
AD2_RS08895	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AD2_RS08905	COG1677	Flagellar hook-basal body complex protein FliE
AD2_RS08910	COG1558	bacterial-type flagellum-dependent cell motility
AD2_RS08915	COG1815	bacterial-type flagellum-dependent cell motility
AD2_RS08920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AD2_RS08925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AD2_RS08930	COG0758	DNA mediated transformation
AD2_RS08930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AD2_RS08935	COG0708	Exodeoxyribonuclease III
AD2_RS08940	COG3304	Inner membrane component domain
AD2_RS08950	COG0606	chelatase, subunit chli
AD2_RS08975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AD2_RS08980	COG1873	PFAM PRC-barrel domain
AD2_RS08985	COG1191	sigma factor activity
AD2_RS08990	COG1191	sigma factor activity
AD2_RS09000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AD2_RS09005	COG0849	cell division
AD2_RS09010	COG3856	small basic protein
AD2_RS09015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AD2_RS09020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AD2_RS09025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AD2_RS09030	COG3442	glutamine amidotransferase
AD2_RS09040	COG3328	transposase activity
AD2_RS09045	COG4447	cellulose binding
AD2_RS09080	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AD2_RS09120	COG1012	belongs to the aldehyde dehydrogenase family
AD2_RS09120	COG1454	alcohol dehydrogenase
AD2_RS09125	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AD2_RS09130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AD2_RS09140	COG0612	Peptidase, M16
AD2_RS09145	COG1185	polyribonucleotide nucleotidyltransferase activity
AD2_RS09150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AD2_RS09165	COG3546	catalase activity
AD2_RS09175	COG2273	Hydrolase Family 16
AD2_RS09175	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_RS09190	COG2848	UPF0210 protein
AD2_RS09195	COG3830	Belongs to the UPF0237 family
AD2_RS09220	COG4447	cellulose binding
AD2_RS09225	COG1191	sigma factor activity
AD2_RS09250	COG0393	Putative heavy-metal-binding
AD2_RS09255	COG1132	(ABC) transporter
AD2_RS09260	COG1132	(ABC) transporter
AD2_RS09265	COG1869	D-ribose catabolic process
AD2_RS09280	COG1172	Belongs to the binding-protein-dependent transport system permease family
AD2_RS09285	COG1129	ABC transporter
AD2_RS09290	COG1940	carbohydrate kinase activity
AD2_RS09295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AD2_RS09300	COG1063	alcohol dehydrogenase
AD2_RS09310	COG1136	(ABC) transporter
AD2_RS09310	COG0577	efflux transmembrane transporter activity
AD2_RS09360	COG0519	Catalyzes the synthesis of GMP from XMP
AD2_RS09365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AD2_RS09380	COG3328	transposase activity
AD2_RS09390	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AD2_RS09395	COG1691	(AIR) carboxylase
AD2_RS09400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AD2_RS09415	COG3620	sequence-specific DNA binding
AD2_RS09425	COG0436	Aminotransferase
AD2_RS09430	COG1522	sequence-specific DNA binding
AD2_RS09440	COG3118	belongs to the thioredoxin family
AD2_RS09450	COG3328	transposase activity
AD2_RS09475	COG3328	transposase activity
AD2_RS09480	COG1379	DNA repair
AD2_RS09485	COG1924	4 iron, 4 sulfur cluster binding
AD2_RS09500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AD2_RS09505	COG0681	Belongs to the peptidase S26 family
AD2_RS09510	COG0191	fructose-bisphosphate aldolase activity
AD2_RS09515	COG0205	6-phosphofructokinase activity
AD2_RS09525	COG0039	L-malate dehydrogenase activity
AD2_RS09530	COG0281	malic enzyme
AD2_RS09555	COG0784	Response regulator, receiver
AD2_RS09555	COG2205	protein histidine kinase activity
AD2_RS09590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AD2_RS09600	COG2226	methyltransferase
AD2_RS09615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AD2_RS09620	COG2911	Protein conserved in bacteria
AD2_RS09620	COG3266	domain, Protein
AD2_RS09620	COG1361	Conserved repeat domain
AD2_RS09650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AD2_RS09650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AD2_RS09655	COG0525	valine-tRNA ligase activity
AD2_RS09665	COG1472	Belongs to the glycosyl hydrolase 3 family
AD2_RS09685	COG1376	ErfK ybiS ycfS ynhG family protein
AD2_RS09695	COG5183	chlorophyll binding
AD2_RS09695	COG2133	pyrroloquinoline quinone binding
AD2_RS09700	COG1191	sigma factor activity
AD2_RS09715	COG0542	response to heat
AD2_RS09730	COG3584	3D domain protein
AD2_RS09730	COG3583	domain protein
AD2_RS09735	COG0556	nucleotide-excision repair
AD2_RS09750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AD2_RS09755	COG0187	DNA topoisomerase II activity
AD2_RS09775	COG2966	Psort location CytoplasmicMembrane, score
AD2_RS09780	COG2340	Cysteine-rich secretory protein family
AD2_RS09785	COG0534	Mate efflux family protein
AD2_RS09790	COG0840	transmembrane signaling receptor activity
AD2_RS09845	COG1331	Highly conserved protein containing a thioredoxin domain
AD2_RS09850	COG0460	homoserine dehydrogenase
AD2_RS09855	COG1199	ATP-dependent helicase activity
AD2_RS09860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AD2_RS09865	COG2205	protein histidine kinase activity
AD2_RS09865	COG0784	Response regulator, receiver
AD2_RS09870	COG2205	protein histidine kinase activity
AD2_RS09875	COG0538	isocitrate dehydrogenase activity
AD2_RS09885	COG0667	Aldo Keto reductase
AD2_RS09890	COG0297	glycogen (starch) synthase activity
AD2_RS09905	COG0564	pseudouridine synthase activity
AD2_RS09910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AD2_RS09910	COG0116	Belongs to the methyltransferase superfamily
AD2_RS09915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AD2_RS09920	COG3459	Glycosyltransferase 36 associated
AD2_RS09925	COG4733	cellulase activity
AD2_RS09925	COG4447	cellulose binding
AD2_RS09930	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_RS09930	COG2199	diguanylate cyclase activity
AD2_RS09935	COG1686	Belongs to the peptidase S11 family
AD2_RS09940	COG4447	cellulose binding
AD2_RS09940	COG4733	cellulase activity
AD2_RS09950	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_RS09955	COG1191	sigma factor activity
AD2_RS09960	COG4447	cellulose binding
AD2_RS09965	COG0840	transmembrane signaling receptor activity
AD2_RS09970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AD2_RS09985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AD2_RS09995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AD2_RS10005	COG4447	cellulose binding
AD2_RS10015	COG1609	Transcriptional regulator
AD2_RS10030	COG0714	Associated with various cellular activities
AD2_RS10045	COG1690	Belongs to the RtcB family
AD2_RS10060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AD2_RS10065	COG3401	FG-GAP repeat protein
AD2_RS10075	COG2217	Heavy metal translocating P-type atpase
AD2_RS10080	COG3409	Peptidoglycan-binding domain 1 protein
AD2_RS10080	COG3773	Cell wall hydrolase
AD2_RS10100	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_RS10110	COG0667	Aldo Keto reductase
AD2_RS10120	COG0318	PFAM AMP-dependent synthetase and ligase
AD2_RS10125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AD2_RS10135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AD2_RS10185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AD2_RS10200	COG3328	transposase activity
AD2_RS10235	COG1408	metallophosphoesterase
AD2_RS10240	COG0166	Belongs to the GPI family
AD2_RS10250	COG0072	phenylalanine-tRNA ligase activity
AD2_RS10250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AD2_RS10255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AD2_RS10265	COG2723	6-phospho-beta-galactosidase activity
AD2_RS10275	COG2273	Hydrolase Family 16
AD2_RS10280	COG1609	Transcriptional regulator
AD2_RS10285	COG1215	transferase activity, transferring glycosyl groups
AD2_RS10295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AD2_RS10295	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AD2_RS10335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AD2_RS10340	COG0493	'glutamate synthase
AD2_RS10340	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AD2_RS10345	COG0069	glutamate synthase activity
AD2_RS10350	COG0067	glutamate synthase
AD2_RS10370	COG0475	glutathione-regulated potassium exporter activity
AD2_RS10385	COG2273	Hydrolase Family 16
AD2_RS10390	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_RS10395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AD2_RS10400	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AD2_RS10405	COG5401	PFAM Sporulation and spore germination
AD2_RS10410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AD2_RS10415	COG0860	N-Acetylmuramoyl-L-alanine amidase
AD2_RS10425	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AD2_RS10430	COG2255	four-way junction helicase activity
AD2_RS10435	COG0632	four-way junction helicase activity
AD2_RS10440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AD2_RS10445	COG0137	argininosuccinate synthase activity
AD2_RS10450	COG0165	Argininosuccinate lyase
AD2_RS10470	COG1368	sulfuric ester hydrolase activity
AD2_RS10475	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AD2_RS10475	COG0493	'glutamate synthase
AD2_RS10505	COG2201	protein-glutamate methylesterase activity
AD2_RS10510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AD2_RS10520	COG1534	Rna-binding protein
AD2_RS10530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AD2_RS10535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AD2_RS10545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AD2_RS10565	COG1470	cell adhesion involved in biofilm formation
AD2_RS10570	COG3906	Belongs to the UPF0473 family
AD2_RS10575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AD2_RS10580	COG0667	Aldo Keto reductase
AD2_RS10585	COG4472	Bacterial protein of unknown function (DUF965)
AD2_RS10590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AD2_RS10605	COG0557	exoribonuclease II activity
AD2_RS10625	COG0148	phosphopyruvate hydratase activity
AD2_RS10630	COG2199	diguanylate cyclase activity
AD2_RS10630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_RS10640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AD2_RS10645	COG0149	triose-phosphate isomerase activity
AD2_RS10650	COG0126	phosphoglycerate kinase activity
AD2_RS10675	COG0318	PFAM AMP-dependent synthetase and ligase
AD2_RS10680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AD2_RS10685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AD2_RS10690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AD2_RS10745	COG1366	Belongs to the anti-sigma-factor antagonist family
AD2_RS10750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AD2_RS10755	COG1481	regulation of sporulation
AD2_RS10765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AD2_RS10770	COG1660	Displays ATPase and GTPase activities
AD2_RS10775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AD2_RS10780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AD2_RS10785	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AD2_RS10810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AD2_RS10830	COG0432	Pfam Uncharacterised protein family UPF0047
AD2_RS10835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AD2_RS10840	COG1979	alcohol dehydrogenase
AD2_RS10850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AD2_RS10855	COG0517	IMP dehydrogenase activity
AD2_RS10855	COG1994	Peptidase M50
AD2_RS10860	COG0739	heme binding
AD2_RS10870	COG1803	Methylglyoxal synthase
AD2_RS10875	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AD2_RS10880	COG2894	cell division
AD2_RS10885	COG0850	regulation of cytokinetic process
AD2_RS10890	COG0768	penicillin binding
AD2_RS10905	COG1077	Cell shape determining protein MreB Mrl
AD2_RS10910	COG0424	maF-like protein
AD2_RS10935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AD2_RS10940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AD2_RS10945	COG0835	chemotaxis
AD2_RS10990	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_RS10990	COG4447	cellulose binding
AD2_RS10995	COG0017	Asparaginyl-tRNA synthetase
AD2_RS11000	COG2502	aspartate--ammonia ligase
AD2_RS11005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AD2_RS11025	COG1283	sodium-dependent phosphate transmembrane transporter activity
AD2_RS11035	COG1368	sulfuric ester hydrolase activity
AD2_RS11040	COG1268	BioY protein
AD2_RS11045	COG0653	protein targeting
AD2_RS11050	COG4447	cellulose binding
AD2_RS11055	COG1191	sigma factor activity
AD2_RS11075	COG1649	PFAM Uncharacterised BCR, COG1649
AD2_RS11080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AD2_RS11125	COG2382	esterase
AD2_RS11125	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS11125	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS11130	COG4733	cellulase activity
AD2_RS11130	COG4447	cellulose binding
AD2_RS11135	COG1160	GTP binding
AD2_RS11145	COG4733	cellulase activity
AD2_RS11145	COG4447	cellulose binding
AD2_RS11150	COG0840	transmembrane signaling receptor activity
AD2_RS11155	COG0835	chemotaxis
AD2_RS11160	COG0840	transmembrane signaling receptor activity
AD2_RS11165	COG0835	chemotaxis
AD2_RS11175	COG1151	hydroxylamine reductase activity
AD2_RS11195	COG4124	Belongs to the glycosyl hydrolase 26 family
AD2_RS11215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AD2_RS11220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AD2_RS11225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AD2_RS11230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AD2_RS11240	COG4106	trans-aconitate 2-methyltransferase activity
AD2_RS11245	COG2267	carboxylic ester hydrolase activity
AD2_RS11250	COG0156	8-amino-7-oxononanoate synthase activity
AD2_RS11255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AD2_RS11260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AD2_RS11285	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS11340	COG3328	transposase activity
AD2_RS11360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AD2_RS11380	COG1595	DNA-templated transcription, initiation
AD2_RS11390	COG4124	Belongs to the glycosyl hydrolase 26 family
AD2_RS11390	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_RS11410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AD2_RS11420	COG0717	Belongs to the dCTP deaminase family
AD2_RS11435	COG2409	Drug exporters of the RND superfamily
AD2_RS11445	COG0561	phosphatase activity
AD2_RS11460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AD2_RS11460	COG0426	domain, Protein
AD2_RS11465	COG0494	nUDIX hydrolase
AD2_RS11475	COG0840	transmembrane signaling receptor activity
AD2_RS11500	COG1695	Transcriptional regulator
AD2_RS11520	COG0840	transmembrane signaling receptor activity
AD2_RS11525	COG0004	ammonium transporteR
AD2_RS11530	COG1132	(ABC) transporter
AD2_RS11535	COG1132	(ABC) transporter
AD2_RS11555	COG1361	Conserved repeat domain
AD2_RS11570	COG1393	Belongs to the ArsC family
AD2_RS11675	COG0577	efflux transmembrane transporter activity
AD2_RS11680	COG1136	(ABC) transporter
AD2_RS11685	COG2205	protein histidine kinase activity
AD2_RS11690	COG0745	RESPONSE REGULATOR receiver
AD2_RS11725	COG1131	(ABC) transporter
AD2_RS11735	COG3620	sequence-specific DNA binding
AD2_RS11745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AD2_RS11750	COG0154	amidase activity
AD2_RS11760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AD2_RS11780	COG1024	Enoyl-CoA hydratase
AD2_RS11785	COG4106	trans-aconitate 2-methyltransferase activity
AD2_RS11790	COG2140	Oxalate decarboxylase
AD2_RS11795	COG2140	Oxalate decarboxylase
AD2_RS11815	COG1464	Belongs to the NlpA lipoprotein family
AD2_RS11820	COG2011	ABC-type metal ion transport system permease component
AD2_RS11825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AD2_RS11835	COG0626	cystathionine gamma-synthase activity
AD2_RS11840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AD2_RS11880	COG0535	radical SAM domain protein
AD2_RS11885	COG2873	o-acetylhomoserine
AD2_RS11890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AD2_RS11895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_RS11905	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AD2_RS11915	COG0813	purine-nucleoside phosphorylase activity
AD2_RS11920	COG1744	ABC transporter substrate-binding protein PnrA-like
AD2_RS11925	COG1328	CTP reductase activity
AD2_RS11930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AD2_RS11935	COG3845	ABC transporter
AD2_RS11940	COG4603	Belongs to the binding-protein-dependent transport system permease family
AD2_RS11945	COG1079	Belongs to the binding-protein-dependent transport system permease family
AD2_RS11950	COG0295	cytidine deaminase activity
AD2_RS11960	COG4753	response regulator
AD2_RS11960	COG2207	Transcriptional regulator
AD2_RS11975	COG3842	ATPase activity
AD2_RS12025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AD2_RS12080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AD2_RS12100	COG3409	Peptidoglycan-binding domain 1 protein
AD2_RS12100	COG5632	N-Acetylmuramoyl-L-alanine amidase
AD2_RS12180	COG0740	serine-type endopeptidase activity
AD2_RS12185	COG4695	Portal protein
AD2_RS12190	COG1802	Transcriptional regulator
AD2_RS12190	COG4626	Terminase
AD2_RS12265	COG1136	(ABC) transporter
AD2_RS12275	COG2205	protein histidine kinase activity
AD2_RS12280	COG0745	RESPONSE REGULATOR receiver
AD2_RS12325	COG1120	ATPase activity
AD2_RS12330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AD2_RS12335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AD2_RS12345	COG0739	heme binding
AD2_RS12365	COG0577	efflux transmembrane transporter activity
AD2_RS12375	COG1136	(ABC) transporter
AD2_RS12415	COG1592	Rubrerythrin
AD2_RS12425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AD2_RS12430	COG1067	ATP-dependent peptidase activity
AD2_RS12435	COG0456	acetyltransferase
AD2_RS12440	COG1214	PFAM Peptidase M22, glycoprotease
AD2_RS12445	COG0802	atpase or kinase
AD2_RS12450	COG1228	amidohydrolase
AD2_RS12475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AD2_RS12480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AD2_RS12490	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AD2_RS12495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AD2_RS12505	COG1215	transferase activity, transferring glycosyl groups
AD2_RS12510	COG0542	response to heat
AD2_RS12515	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AD2_RS12520	COG3880	PFAM UvrB UvrC protein
AD2_RS12545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AD2_RS12550	COG0287	Prephenate dehydrogenase
AD2_RS12555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AD2_RS12560	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AD2_RS12565	COG0488	(ABC) transporter
AD2_RS12575	COG1122	ATPase activity
AD2_RS12585	COG0310	cobalt ion transport
AD2_RS12590	COG0860	N-Acetylmuramoyl-L-alanine amidase
AD2_RS12595	COG0745	RESPONSE REGULATOR receiver
AD2_RS12620	COG1595	DNA-templated transcription, initiation
AD2_RS12635	COG0829	nickel cation binding
AD2_RS12640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AD2_RS12650	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AD2_RS12655	COG0804	urea catabolic process
AD2_RS12660	COG0832	Belongs to the urease beta subunit family
AD2_RS12665	COG0831	urea catabolic process
AD2_RS12695	COG2207	Transcriptional regulator
AD2_RS12695	COG4753	response regulator
AD2_RS12705	COG4251	negative regulation of phosphorylation
AD2_RS12780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AD2_RS12790	COG1606	tRNA processing
AD2_RS12800	COG1959	2 iron, 2 sulfur cluster binding
AD2_RS12805	COG1959	2 iron, 2 sulfur cluster binding
AD2_RS12810	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AD2_RS12815	COG5002	protein histidine kinase activity
AD2_RS12820	COG0745	RESPONSE REGULATOR receiver
AD2_RS12825	COG2217	Heavy metal translocating P-type atpase
AD2_RS12870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AD2_RS12875	COG1278	Cold shock
AD2_RS12880	COG3695	enzyme binding
AD2_RS12895	COG3409	Peptidoglycan-binding domain 1 protein
AD2_RS12895	COG0793	Belongs to the peptidase S41A family
AD2_RS12905	COG2177	Part of the ABC transporter FtsEX involved in
AD2_RS12910	COG2884	Cell division ATP-binding protein ftsE
AD2_RS12915	COG3835	regulator
AD2_RS12920	COG3842	ATPase activity
AD2_RS12925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AD2_RS12930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AD2_RS12940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AD2_RS12945	COG0505	Belongs to the CarA family
AD2_RS12950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AD2_RS12955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AD2_RS12970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_RS12990	COG1695	Transcriptional regulator
AD2_RS12995	COG1408	metallophosphoesterase
AD2_RS13010	COG1876	peptidase activity
AD2_RS13020	COG3328	transposase activity
AD2_RS13030	COG0726	polysaccharide deacetylase
AD2_RS13050	COG1028	Short-chain dehydrogenase reductase Sdr
AD2_RS13050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AD2_RS13050	COG3321	synthase
AD2_RS13050	COG0318	PFAM AMP-dependent synthetase and ligase
AD2_RS13050	COG0300	oxidoreductase activity
AD2_RS13095	COG5002	protein histidine kinase activity
AD2_RS13100	COG0745	RESPONSE REGULATOR receiver
AD2_RS13105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AD2_RS13110	COG1982	Orn Lys Arg decarboxylase major
AD2_RS13115	COG1285	pathogenesis
AD2_RS13125	COG1695	Transcriptional regulator
AD2_RS13135	COG0504	CTP synthase activity
AD2_RS13140	COG3328	transposase activity
AD2_RS13160	COG0793	Belongs to the peptidase S41A family
AD2_RS13160	COG3409	Peptidoglycan-binding domain 1 protein
AD2_RS13175	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AD2_RS13185	COG0018	arginyl-trna synthetase
AD2_RS13195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AD2_RS13200	COG1181	Belongs to the D-alanine--D-alanine ligase family
AD2_RS13205	COG2239	Acts as a magnesium transporter
AD2_RS13225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AD2_RS13230	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AD2_RS13235	COG0492	ferredoxin-NADP+ reductase activity
AD2_RS13245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AD2_RS13250	COG0785	Cytochrome C biogenesis protein
AD2_RS13280	COG2183	response to ionizing radiation
AD2_RS13305	COG2226	methyltransferase
AD2_RS13315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AD2_RS13325	COG2382	esterase
AD2_RS13325	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS13325	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS13330	COG3634	alkyl hydroperoxide reductase activity
AD2_RS13335	COG0450	alkyl hydroperoxide reductase
AD2_RS13345	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AD2_RS13505	COG3328	transposase activity
AD2_RS13540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AD2_RS13665	COG0457	Tetratricopeptide repeat
AD2_RS13665	COG0515	serine threonine protein kinase
AD2_RS13675	COG2226	methyltransferase
AD2_RS13690	COG3328	transposase activity
AD2_RS13700	COG1074	ATP-dependent DNA helicase activity
AD2_RS13705	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AD2_RS13820	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AD2_RS13840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AD2_RS13850	COG0697	spore germination
AD2_RS13865	COG0215	cysteine-tRNA ligase activity
AD2_RS13870	COG1045	serine acetyltransferase
AD2_RS13910	COG1473	amidohydrolase
AD2_RS13915	COG2155	Conserved Protein
AD2_RS13920	COG0217	transcriptional regulatory protein
AD2_RS13935	COG1739	Uncharacterized protein family UPF0029
AD2_RS13940	COG0681	Belongs to the peptidase S26 family
AD2_RS13945	COG0494	nUDIX hydrolase
AD2_RS13950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AD2_RS13960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AD2_RS13970	COG0756	dUTP diphosphatase activity
AD2_RS13975	COG0826	peptidase U32
AD2_RS13980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AD2_RS13990	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_RS14010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AD2_RS14015	COG3584	3D domain protein
AD2_RS14015	COG3583	domain protein
AD2_RS14025	COG0084	hydrolase, TatD family'
AD2_RS14030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AD2_RS14030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AD2_RS14040	COG0700	Nucleoside recognition
AD2_RS14045	COG2715	membrane protein required for spore maturation
AD2_RS14050	COG2002	toxin-antitoxin pair type II binding
AD2_RS14055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AD2_RS14060	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AD2_RS14070	COG1774	PSP1 C-terminal conserved region
AD2_RS14075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AD2_RS14080	COG1728	Protein conserved in bacteria
AD2_RS14090	COG1982	Orn Lys Arg decarboxylase major
AD2_RS14105	COG1136	(ABC) transporter
AD2_RS14120	COG5002	protein histidine kinase activity
AD2_RS14130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_RS14135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AD2_RS14145	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS14150	COG1191	sigma factor activity
AD2_RS14175	COG0395	ABC-type sugar transport system, permease component
AD2_RS14180	COG1175	transmembrane transport
AD2_RS14185	COG0714	Associated with various cellular activities
AD2_RS14230	COG3940	Belongs to the glycosyl hydrolase 43 family
AD2_RS14235	COG3940	Belongs to the glycosyl hydrolase 43 family
AD2_RS14250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AD2_RS14255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AD2_RS14260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AD2_RS14265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AD2_RS14330	COG1361	Conserved repeat domain
AD2_RS14365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AD2_RS14375	COG1773	rubredoxin
AD2_RS14400	COG1408	metallophosphoesterase
AD2_RS14415	COG0254	rRNA binding
AD2_RS14420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AD2_RS14485	COG0038	chloride channel
AD2_RS14495	COG0037	tRNA processing
AD2_RS14505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AD2_RS14510	COG1295	ribonuclease BN
AD2_RS14515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AD2_RS14520	COG0629	single-stranded DNA binding
AD2_RS14525	COG0360	Binds together with S18 to 16S ribosomal RNA
AD2_RS14535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AD2_RS14540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AD2_RS14555	COG2382	esterase
AD2_RS14555	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS14555	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS14560	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS14565	COG2382	esterase
AD2_RS14565	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS14565	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS14570	COG2382	esterase
AD2_RS14570	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS14570	COG3693	PFAM glycoside hydrolase, family 10
AD2_RS14575	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_RS14580	COG3250	beta-galactosidase activity
AD2_RS14595	COG0789	Transcriptional regulator
AD2_RS14595	COG4978	Transcriptional regulator
AD2_RS14600	COG0577	efflux transmembrane transporter activity
AD2_RS14605	COG1136	(ABC) transporter
AD2_RS14610	COG5002	protein histidine kinase activity
AD2_RS14615	COG0745	RESPONSE REGULATOR receiver
AD2_RS14660	COG0302	gtp cyclohydrolase
AD2_RS14665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AD2_RS14665	COG1181	Belongs to the D-alanine--D-alanine ligase family
AD2_RS14670	COG4242	Belongs to the peptidase S51 family
AD2_RS14680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AD2_RS14690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AD2_RS14695	COG0473	3-isopropylmalate dehydrogenase activity
AD2_RS14700	COG0066	3-isopropylmalate dehydratase activity
AD2_RS14705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AD2_RS14710	COG2207	Transcriptional regulator
AD2_RS14715	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AD2_RS14740	COG1516	flagellar protein fliS
AD2_RS14745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AD2_RS14755	COG1088	dTDP-glucose 4,6-dehydratase activity
AD2_RS14760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AD2_RS14775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AD2_RS14790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AD2_RS14800	COG2089	acid synthase
AD2_RS14805	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AD2_RS14810	COG2226	methyltransferase
AD2_RS14815	COG1086	Polysaccharide biosynthesis protein
AD2_RS14835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AD2_RS14840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AD2_RS14850	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AD2_RS14855	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AD2_RS14865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AD2_RS14870	COG1256	bacterial-type flagellum assembly
AD2_RS14870	COG4786	Flagellar basal body rod
AD2_RS14895	COG1040	competence protein
AD2_RS14900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AD2_RS14910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AD2_RS14920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AD2_RS14925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AD2_RS14930	COG0037	tRNA processing
AD2_RS14935	COG0305	Participates in initiation and elongation during chromosome replication
AD2_RS14940	COG0359	binds to the 23S rRNA
AD2_RS14945	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AD2_RS14955	COG1605	Chorismate mutase
AD2_RS14955	COG0077	Prephenate dehydratase
AD2_RS14965	COG1269	ATP hydrolysis coupled proton transport
AD2_RS14970	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AD2_RS14975	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
AD2_RS14990	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AD2_RS14995	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AD2_RS15000	COG1394	ATPase activity, coupled to movement of substances
AD2_RS15005	COG0488	(ABC) transporter
AD2_RS15040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AD2_RS15055	COG0765	amino acid transport
AD2_RS15065	COG2201	protein-glutamate methylesterase activity
AD2_RS15070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AD2_RS15080	COG0643	Histidine kinase
AD2_RS15080	COG2198	Histidine kinase
AD2_RS15085	COG0835	chemotaxis
AD2_RS15090	COG0582	viral genome integration into host DNA
AD2_RS15095	COG3708	Transcriptional regulator
AD2_RS15095	COG2207	Transcriptional regulator
AD2_RS15110	COG1131	(ABC) transporter
AD2_RS15130	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AD2_RS15135	COG1518	maintenance of DNA repeat elements
AD2_RS15175	COG1968	undecaprenyl-diphosphatase activity
AD2_RS15180	COG0534	Mate efflux family protein
AD2_RS15230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AD2_RS15235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AD2_RS15240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AD2_RS15260	COG5002	protein histidine kinase activity
AD2_RS15265	COG0745	RESPONSE REGULATOR receiver
AD2_RS15290	COG0438	transferase activity, transferring glycosyl groups
AD2_RS15300	COG0438	transferase activity, transferring glycosyl groups
AD2_RS15330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AD2_RS15335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AD2_RS15350	COG1361	Conserved repeat domain
AD2_RS15360	COG3773	Cell wall hydrolase
AD2_RS15370	COG0517	IMP dehydrogenase activity
AD2_RS15385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AD2_RS15390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AD2_RS15425	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AD2_RS15430	COG4447	cellulose binding
AD2_RS15430	COG4733	cellulase activity
AD2_RS15435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AD2_RS15440	COG1475	DNA binding
AD2_RS15445	COG0357	Ribosomal RNA small subunit methyltransferase G
AD2_RS15450	COG0445	tRNA wobble uridine modification
AD2_RS15455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AD2_RS15460	COG1847	R3H domain protein
AD2_RS15465	COG0706	membrane insertase activity
AD2_RS15470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AD2_RS15480	COG0230	Belongs to the bacterial ribosomal protein bL34 family