locus-tag	class	description
GKP14_RS00125	COG1481	regulation of sporulation
GKP14_RS00130	COG1660	Displays ATPase and GTPase activities
GKP14_RS00135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GKP14_RS00140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GKP14_RS00145	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GKP14_RS00160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GKP14_RS00165	COG0497	DNA recombination
GKP14_RS00170	COG1438	arginine binding
GKP14_RS00175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GKP14_RS00180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GKP14_RS00185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GKP14_RS00190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GKP14_RS00195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GKP14_RS00200	COG0612	Peptidase, M16
GKP14_RS00210	COG0697	spore germination
GKP14_RS00215	COG0295	cytidine deaminase activity
GKP14_RS00230	COG1477	protein flavinylation
GKP14_RS00250	COG4656	Part of a membrane complex involved in electron transport
GKP14_RS00255	COG4658	electron transport chain
GKP14_RS00260	COG4659	FMN binding
GKP14_RS00265	COG4660	Part of a membrane complex involved in electron transport
GKP14_RS00270	COG4657	Part of a membrane complex involved in electron transport
GKP14_RS00275	COG2878	Part of a membrane complex involved in electron transport
GKP14_RS00280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GKP14_RS00290	COG0525	valine-tRNA ligase activity
GKP14_RS00295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKP14_RS00300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKP14_RS00305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GKP14_RS00320	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GKP14_RS00325	COG2723	6-phospho-beta-galactosidase activity
GKP14_RS00340	COG1686	Belongs to the peptidase S11 family
GKP14_RS00345	COG1132	(ABC) transporter
GKP14_RS00350	COG4684	Psort location CytoplasmicMembrane, score
GKP14_RS00355	COG0107	imidazoleglycerol-phosphate synthase activity
GKP14_RS00360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GKP14_RS00375	COG0427	acetyl-CoA hydrolase
GKP14_RS00385	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKP14_RS00390	COG1024	Enoyl-CoA hydratase
GKP14_RS00395	COG0183	Belongs to the thiolase family
GKP14_RS00400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKP14_RS00420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKP14_RS00420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKP14_RS00435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GKP14_RS00440	COG0726	polysaccharide deacetylase
GKP14_RS00440	COG1649	PFAM Uncharacterised BCR, COG1649
GKP14_RS00480	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GKP14_RS00490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GKP14_RS00500	COG0629	single-stranded DNA binding
GKP14_RS00505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GKP14_RS00510	COG2323	membrane
GKP14_RS00520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GKP14_RS00530	COG0252	asparaginase activity
GKP14_RS00540	COG0488	(ABC) transporter
GKP14_RS00545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKP14_RS00555	COG1115	amino acid carrier protein
GKP14_RS00575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GKP14_RS00580	COG3853	Toxic anion resistance protein (TelA)
GKP14_RS00650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GKP14_RS00655	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GKP14_RS00660	COG0697	spore germination
GKP14_RS00665	COG1295	ribonuclease BN
GKP14_RS00690	COG0745	RESPONSE REGULATOR receiver
GKP14_RS00690	COG3292	Two component regulator propeller
GKP14_RS00690	COG2205	protein histidine kinase activity
GKP14_RS00710	COG0432	Pfam Uncharacterised protein family UPF0047
GKP14_RS00725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GKP14_RS00735	COG0561	phosphatase activity
GKP14_RS00745	COG1879	ABC-type sugar transport system periplasmic component
GKP14_RS00750	COG1172	Belongs to the binding-protein-dependent transport system permease family
GKP14_RS00755	COG1129	ABC transporter
GKP14_RS00760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKP14_RS00770	COG1869	D-ribose catabolic process
GKP14_RS00775	COG0584	glycerophosphoryl diester phosphodiesterase
GKP14_RS00780	COG0071	Belongs to the small heat shock protein (HSP20) family
GKP14_RS00785	COG0778	Nitroreductase
GKP14_RS00800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKP14_RS00825	COG2059	Chromate
GKP14_RS00830	COG0242	peptide deformylase activity
GKP14_RS00840	COG2246	polysaccharide biosynthetic process
GKP14_RS00850	COG0326	Molecular chaperone. Has ATPase activity
GKP14_RS00895	COG2972	Histidine kinase
GKP14_RS00910	COG4209	transmembrane transport
GKP14_RS00915	COG0395	ABC-type sugar transport system, permease component
GKP14_RS00920	COG0366	Alpha amylase catalytic
GKP14_RS00950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GKP14_RS00955	COG1940	carbohydrate kinase activity
GKP14_RS00965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKP14_RS00970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKP14_RS00975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKP14_RS00980	COG0017	Asparaginyl-tRNA synthetase
GKP14_RS01040	COG1342	Belongs to the UPF0251 family
GKP14_RS01050	COG2801	Transposase and inactivated derivatives
GKP14_RS01070	COG2801	Transposase and inactivated derivatives
GKP14_RS01095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKP14_RS01105	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GKP14_RS01110	COG0205	6-phosphofructokinase activity
GKP14_RS01120	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GKP14_RS01125	COG1518	maintenance of DNA repeat elements
GKP14_RS01135	COG1203	CRISPR-associated helicase, Cas3
GKP14_RS01180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GKP14_RS01185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GKP14_RS01190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKP14_RS01195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GKP14_RS01200	COG0772	Belongs to the SEDS family
GKP14_RS01205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKP14_RS01215	COG0768	penicillin binding
GKP14_RS01235	COG0459	protein refolding
GKP14_RS01240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GKP14_RS01245	COG0116	Belongs to the methyltransferase superfamily
GKP14_RS01250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GKP14_RS01265	COG1098	S1 RNA binding domain
GKP14_RS01285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GKP14_RS01295	COG0776	regulation of translation
GKP14_RS01300	COG3956	TIGRFAM MazG family protein
GKP14_RS01315	COG0572	uridine kinase
GKP14_RS01320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GKP14_RS01325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKP14_RS01330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GKP14_RS01335	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GKP14_RS01335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GKP14_RS01345	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GKP14_RS01360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GKP14_RS01365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GKP14_RS01380	COG1392	Phosphate transport regulator
GKP14_RS01385	COG0306	phosphate transporter
GKP14_RS01390	COG0726	polysaccharide deacetylase
GKP14_RS01410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GKP14_RS01415	COG1120	ATPase activity
GKP14_RS01420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKP14_RS01435	COG0492	ferredoxin-NADP+ reductase activity
GKP14_RS01460	COG0681	Belongs to the peptidase S26 family
GKP14_RS01470	COG1131	(ABC) transporter
GKP14_RS01485	COG1131	(ABC) transporter
GKP14_RS01490	COG1725	Transcriptional regulator
GKP14_RS01505	COG1131	(ABC) transporter
GKP14_RS01545	COG0367	asparagine synthase
GKP14_RS01565	COG2873	o-acetylhomoserine
GKP14_RS01590	COG0557	exoribonuclease II activity
GKP14_RS01595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GKP14_RS01600	COG1126	abc transporter atp-binding protein
GKP14_RS01605	COG0765	amino acid transport
GKP14_RS01610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GKP14_RS01620	COG0187	DNA topoisomerase II activity
GKP14_RS01625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GKP14_RS01635	COG0037	tRNA processing
GKP14_RS01640	COG0305	Participates in initiation and elongation during chromosome replication
GKP14_RS01645	COG0359	binds to the 23S rRNA
GKP14_RS01650	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GKP14_RS01655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GKP14_RS01660	COG0328	RNA-DNA hybrid ribonuclease activity
GKP14_RS01670	COG1376	ErfK ybiS ycfS ynhG family protein
GKP14_RS01690	COG0406	alpha-ribazole phosphatase activity
GKP14_RS01695	COG0058	SHG alpha-glucan phosphorylase activity
GKP14_RS01725	COG0280	phosphate acetyltransferase
GKP14_RS01730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GKP14_RS01740	COG1131	(ABC) transporter
GKP14_RS01750	COG1966	Carbon starvation protein
GKP14_RS01755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GKP14_RS01760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GKP14_RS01810	COG1609	Transcriptional regulator
GKP14_RS01820	COG1132	(ABC) transporter
GKP14_RS01830	COG1846	Transcriptional regulator
GKP14_RS01850	COG0569	domain protein
GKP14_RS01865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GKP14_RS01880	COG0803	Belongs to the bacterial solute-binding protein 9 family
GKP14_RS01890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GKP14_RS01895	COG2226	methyltransferase
GKP14_RS01900	COG4667	esterase of the alpha-beta hydrolase superfamily
GKP14_RS01925	COG0363	glucosamine-6-phosphate deaminase activity
GKP14_RS01930	COG2190	(PTS) system
GKP14_RS01950	COG1737	Transcriptional regulator
GKP14_RS01955	COG0561	phosphatase activity
GKP14_RS01970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GKP14_RS01975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GKP14_RS01980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GKP14_RS01985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GKP14_RS01995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKP14_RS02005	COG4221	oxidoreductase activity
GKP14_RS02050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GKP14_RS02060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GKP14_RS02065	COG1316	TRANSCRIPTIONal
GKP14_RS02070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKP14_RS02070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKP14_RS02080	COG0084	hydrolase, TatD family'
GKP14_RS02085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GKP14_RS02090	COG1177	transmembrane transport
GKP14_RS02095	COG1176	ABC-type spermidine putrescine transport system, permease component I
GKP14_RS02100	COG3842	ATPase activity
GKP14_RS02110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GKP14_RS02115	COG2011	ABC-type metal ion transport system permease component
GKP14_RS02120	COG1464	Belongs to the NlpA lipoprotein family
GKP14_RS02130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKP14_RS02140	COG1307	EDD domain protein, DegV family
GKP14_RS02145	COG2337	Toxic component of a toxin-antitoxin (TA) module
GKP14_RS02150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GKP14_RS02150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GKP14_RS02155	COG0736	holo-[acyl-carrier-protein] synthase activity
GKP14_RS02165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GKP14_RS02170	COG0072	phenylalanine-tRNA ligase activity
GKP14_RS02170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKP14_RS02175	COG4472	Bacterial protein of unknown function (DUF965)
GKP14_RS02185	COG0151	Belongs to the GarS family
GKP14_RS02200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GKP14_RS02205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GKP14_RS02210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GKP14_RS02235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GKP14_RS02240	COG0742	ribosomal rna small subunit methyltransferase
GKP14_RS02245	COG0322	excinuclease ABC activity
GKP14_RS02250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKP14_RS02255	COG0336	Belongs to the RNA methyltransferase TrmD family
GKP14_RS02260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GKP14_RS02265	COG1837	Belongs to the UPF0109 family
GKP14_RS02270	COG0228	four-way junction DNA binding
GKP14_RS02275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GKP14_RS02280	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GKP14_RS02295	COG1115	amino acid carrier protein
GKP14_RS02305	COG2252	PERMEase
GKP14_RS02315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GKP14_RS02325	COG0546	phosphoglycolate phosphatase activity
GKP14_RS02330	COG0561	phosphatase activity
GKP14_RS02340	COG0697	spore germination
GKP14_RS02345	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GKP14_RS02350	COG1827	regulation of RNA biosynthetic process
GKP14_RS02360	COG0352	thiamine-phosphate diphosphorylase activity
GKP14_RS02365	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GKP14_RS02385	COG4166	transmembrane transport
GKP14_RS02390	COG0488	(ABC) transporter
GKP14_RS02395	COG3546	catalase activity
GKP14_RS02400	COG0662	Cupin 2, conserved barrel domain protein
GKP14_RS02440	COG2340	Cysteine-rich secretory protein family
GKP14_RS02460	COG0463	Glycosyl transferase, family 2
GKP14_RS02505	COG3279	Response regulator of the LytR AlgR family
GKP14_RS02510	COG1132	(ABC) transporter
GKP14_RS02520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GKP14_RS02525	COG4948	Mandelate Racemase Muconate Lactonizing
GKP14_RS02530	COG0203	ribosomal protein L17
GKP14_RS02535	COG0202	RNA polymerase activity
GKP14_RS02540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GKP14_RS02545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GKP14_RS02550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GKP14_RS02555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GKP14_RS02560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GKP14_RS02575	COG0563	adenylate kinase activity
GKP14_RS02580	COG0201	protein transport
GKP14_RS02585	COG0200	Binds to the 23S rRNA
GKP14_RS02595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GKP14_RS02600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GKP14_RS02605	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GKP14_RS02610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GKP14_RS02615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GKP14_RS02620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GKP14_RS02625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GKP14_RS02630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GKP14_RS02635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GKP14_RS02640	COG0255	Belongs to the universal ribosomal protein uL29 family
GKP14_RS02645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GKP14_RS02655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GKP14_RS02660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GKP14_RS02665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GKP14_RS02670	COG0089	rRNA binding
GKP14_RS02675	COG0088	Forms part of the polypeptide exit tunnel
GKP14_RS02680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GKP14_RS02685	COG0051	transcription antitermination factor activity, RNA binding
GKP14_RS02690	COG1442	glycosyl transferase family 8
GKP14_RS02700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GKP14_RS02705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKP14_RS02710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GKP14_RS02715	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GKP14_RS02720	COG0287	Prephenate dehydrogenase
GKP14_RS02725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GKP14_RS02730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GKP14_RS02735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GKP14_RS02740	COG0077	Prephenate dehydratase
GKP14_RS02740	COG1605	Chorismate mutase
GKP14_RS02745	COG0251	oxidation-reduction process
GKP14_RS02755	COG0310	cobalt ion transport
GKP14_RS02765	COG1122	ATPase activity
GKP14_RS02775	COG0419	ATPase involved in DNA repair
GKP14_RS02780	COG0420	3'-5' exonuclease activity
GKP14_RS02785	COG1686	Belongs to the peptidase S11 family
GKP14_RS02790	COG0222	ribosome binding
GKP14_RS02795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GKP14_RS02800	COG0081	regulation of translation
GKP14_RS02805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GKP14_RS02810	COG0250	Participates in transcription elongation, termination and antitermination
GKP14_RS02820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GKP14_RS02830	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKP14_RS02835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GKP14_RS02845	COG0018	arginyl-trna synthetase
GKP14_RS02855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GKP14_RS02870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GKP14_RS02880	COG1396	sequence-specific DNA binding
GKP14_RS02880	COG3800	Transcriptional regulator
GKP14_RS02890	COG0297	glycogen (starch) synthase activity
GKP14_RS02895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GKP14_RS02905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GKP14_RS02920	COG0372	Belongs to the citrate synthase family
GKP14_RS02930	COG4166	transmembrane transport
GKP14_RS02960	COG0126	phosphoglycerate kinase activity
GKP14_RS02965	COG0149	triose-phosphate isomerase activity
GKP14_RS02990	COG1253	flavin adenine dinucleotide binding
GKP14_RS02995	COG1013	pyruvate-flavodoxin oxidoreductase activity
GKP14_RS02995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GKP14_RS02995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GKP14_RS02995	COG0674	pyruvate-flavodoxin oxidoreductase activity
GKP14_RS03000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKP14_RS03015	COG1546	Belongs to the CinA family
GKP14_RS03015	COG1058	Belongs to the CinA family
GKP14_RS03020	COG0301	tRNA thio-modification
GKP14_RS03025	COG1104	cysteine desulfurase activity
GKP14_RS03030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GKP14_RS03040	COG1216	Glycosyl transferase, family 2
GKP14_RS03055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKP14_RS03070	COG1234	tRNA 3'-trailer cleavage
GKP14_RS03080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GKP14_RS03090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKP14_RS03090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKP14_RS03095	COG2226	methyltransferase
GKP14_RS03105	COG1396	sequence-specific DNA binding
GKP14_RS03110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GKP14_RS03120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GKP14_RS03130	COG4166	transmembrane transport
GKP14_RS03135	COG1304	FMN binding
GKP14_RS03140	COG2190	(PTS) system
GKP14_RS03140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GKP14_RS03140	COG1263	PTS System
GKP14_RS03145	COG3711	transcriptional antiterminator
GKP14_RS03150	COG2801	Transposase and inactivated derivatives
GKP14_RS03160	COG0740	serine-type endopeptidase activity
GKP14_RS03240	COG4221	oxidoreductase activity
GKP14_RS03250	COG0010	Belongs to the arginase family
GKP14_RS03260	COG2177	Part of the ABC transporter FtsEX involved in
GKP14_RS03265	COG2884	Cell division ATP-binding protein ftsE
GKP14_RS03270	COG3835	regulator
GKP14_RS03275	COG3842	ATPase activity
GKP14_RS03280	COG1187	pseudouridine synthase activity
GKP14_RS03290	COG1876	peptidase activity
GKP14_RS03300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GKP14_RS03305	COG0165	Argininosuccinate lyase
GKP14_RS03310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKP14_RS03310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKP14_RS03310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKP14_RS03340	COG0028	Belongs to the TPP enzyme family
GKP14_RS03345	COG0440	acetolactate synthase activity
GKP14_RS03350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GKP14_RS03375	COG0438	transferase activity, transferring glycosyl groups
GKP14_RS03415	COG2314	TM2 domain
GKP14_RS03420	COG0012	GTP binding
GKP14_RS03425	COG1592	Rubrerythrin
GKP14_RS03445	COG0534	Mate efflux family protein
GKP14_RS03455	COG0039	L-malate dehydrogenase activity
GKP14_RS03460	COG1193	negative regulation of DNA recombination
GKP14_RS03465	COG1381	Involved in DNA repair and RecF pathway recombination
GKP14_RS03470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GKP14_RS03520	COG0436	Aminotransferase
GKP14_RS03530	COG0159	tryptophan synthase activity
GKP14_RS03535	COG0133	tryptophan synthase activity
GKP14_RS03560	COG0482	sulfurtransferase activity
GKP14_RS03565	COG0038	chloride channel
GKP14_RS03575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKP14_RS03600	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GKP14_RS03610	COG2155	Conserved Protein
GKP14_RS03615	COG1185	polyribonucleotide nucleotidyltransferase activity
GKP14_RS03630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GKP14_RS03640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GKP14_RS03645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GKP14_RS03655	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GKP14_RS03660	COG0195	Participates in both transcription termination and antitermination
GKP14_RS03670	COG2002	toxin-antitoxin pair type II binding
GKP14_RS03690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GKP14_RS03695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GKP14_RS03705	COG1268	BioY protein
GKP14_RS03715	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GKP14_RS03755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKP14_RS03815	COG2188	Transcriptional regulator
GKP14_RS03820	COG0366	Alpha amylase catalytic
GKP14_RS03825	COG1263	PTS System
GKP14_RS03825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GKP14_RS03825	COG2190	(PTS) system
GKP14_RS03835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GKP14_RS03845	COG0740	serine-type endopeptidase activity
GKP14_RS03890	COG1104	cysteine desulfurase activity
GKP14_RS03925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GKP14_RS03930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GKP14_RS03935	COG0546	phosphoglycolate phosphatase activity
GKP14_RS03955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GKP14_RS03960	COG2186	Transcriptional regulator
GKP14_RS03965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKP14_RS03970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKP14_RS03970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKP14_RS03970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKP14_RS03980	COG3711	transcriptional antiterminator
GKP14_RS03985	COG0671	phosphoesterase, PA-phosphatase related
GKP14_RS04015	COG1151	hydroxylamine reductase activity
GKP14_RS04040	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GKP14_RS04055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GKP14_RS04065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GKP14_RS04070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKP14_RS04075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GKP14_RS04080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GKP14_RS04085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GKP14_RS04105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GKP14_RS04185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKP14_RS04190	COG5002	protein histidine kinase activity
GKP14_RS04195	COG0745	RESPONSE REGULATOR receiver
GKP14_RS04220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GKP14_RS04225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKP14_RS04230	COG0484	heat shock protein binding
GKP14_RS04235	COG0443	Heat shock 70 kDa protein
GKP14_RS04245	COG1420	regulation of RNA biosynthetic process
GKP14_RS04250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GKP14_RS04255	COG0481	GTPase activity
GKP14_RS04280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GKP14_RS04285	COG0268	Binds directly to 16S ribosomal RNA
GKP14_RS04300	COG0534	Mate efflux family protein
GKP14_RS04320	COG0617	tRNA 3'-terminal CCA addition
GKP14_RS04325	COG1191	sigma factor activity
GKP14_RS04340	COG2195	Cleaves the N-terminal amino acid of tripeptides
GKP14_RS04350	COG2011	ABC-type metal ion transport system permease component
GKP14_RS04355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GKP14_RS04360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GKP14_RS04370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKP14_RS04380	COG0191	fructose-bisphosphate aldolase activity
GKP14_RS04390	COG0653	protein targeting
GKP14_RS04395	COG1063	alcohol dehydrogenase
GKP14_RS04400	COG1105	Belongs to the carbohydrate kinase PfkB family
GKP14_RS04415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKP14_RS04420	COG3711	transcriptional antiterminator
GKP14_RS04425	COG2213	PTS system mannitol-specific
GKP14_RS04445	COG5002	protein histidine kinase activity
GKP14_RS04450	COG0745	RESPONSE REGULATOR receiver
GKP14_RS04455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKP14_RS04485	COG3103	Sh3 type 3 domain protein
GKP14_RS04485	COG0366	Alpha amylase catalytic
GKP14_RS04490	COG0058	SHG alpha-glucan phosphorylase activity
GKP14_RS04500	COG0826	peptidase U32
GKP14_RS04505	COG0756	dUTP diphosphatase activity
GKP14_RS04510	COG1077	Cell shape determining protein MreB Mrl
GKP14_RS04530	COG2894	cell division
GKP14_RS04535	COG1803	Methylglyoxal synthase
GKP14_RS04540	COG0124	histidyl-tRNA synthetase
GKP14_RS04545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GKP14_RS04555	COG1733	regulation of RNA biosynthetic process
GKP14_RS04570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GKP14_RS04575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GKP14_RS04580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GKP14_RS04590	COG1774	PSP1 C-terminal conserved region
GKP14_RS04600	COG3870	Protein conserved in bacteria
GKP14_RS04605	COG1982	Orn Lys Arg decarboxylase major
GKP14_RS04610	COG1316	TRANSCRIPTIONal
GKP14_RS04615	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GKP14_RS04625	COG1136	(ABC) transporter
GKP14_RS04625	COG0577	efflux transmembrane transporter activity
GKP14_RS04630	COG1136	(ABC) transporter
GKP14_RS04650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GKP14_RS04655	COG0733	neurotransmitter:sodium symporter activity
GKP14_RS04665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GKP14_RS04675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKP14_RS04675	COG0574	Belongs to the PEP-utilizing enzyme family
GKP14_RS04690	COG1349	DNA-binding transcription factor activity
GKP14_RS04695	COG1105	Belongs to the carbohydrate kinase PfkB family
GKP14_RS04700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKP14_RS04700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKP14_RS04700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKP14_RS04705	COG1331	Highly conserved protein containing a thioredoxin domain
GKP14_RS04710	COG0445	tRNA wobble uridine modification
GKP14_RS04730	COG0579	oxidoreductase
GKP14_RS04740	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GKP14_RS04750	COG0187	DNA topoisomerase II activity
GKP14_RS04770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKP14_RS04780	COG0592	DNA-directed DNA polymerase activity
GKP14_RS04790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GKP14_RS04795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GKP14_RS04800	COG0594	ribonuclease P activity
GKP14_RS04805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GKP14_RS04810	COG0706	membrane insertase activity
GKP14_RS04815	COG1847	R3H domain protein
GKP14_RS04820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GKP14_RS04825	COG0445	tRNA wobble uridine modification
GKP14_RS04830	COG0357	Ribosomal RNA small subunit methyltransferase G
GKP14_RS04835	COG1475	DNA binding
GKP14_RS04840	COG1192	Involved in chromosome partitioning
GKP14_RS04845	COG1475	DNA binding
GKP14_RS04850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GKP14_RS04860	COG0517	IMP dehydrogenase activity
GKP14_RS04860	COG0516	GMP reductase activity
GKP14_RS04930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GKP14_RS04940	COG1609	Transcriptional regulator
GKP14_RS04950	COG0739	heme binding
GKP14_RS04955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GKP14_RS04960	COG0352	thiamine-phosphate diphosphorylase activity
GKP14_RS04960	COG0351	phosphomethylpyrimidine kinase
GKP14_RS04975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GKP14_RS04980	COG1461	Dihydroxyacetone kinase
GKP14_RS04985	COG1692	metallophosphoesterase
GKP14_RS04990	COG1418	mRNA catabolic process
GKP14_RS04995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GKP14_RS05000	COG0028	Belongs to the TPP enzyme family
GKP14_RS05010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GKP14_RS05025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GKP14_RS05035	COG0426	domain, Protein
GKP14_RS05055	COG5002	protein histidine kinase activity
GKP14_RS05060	COG3872	metal-dependent enzyme
GKP14_RS05065	COG2890	protein-(glutamine-N5) methyltransferase activity
GKP14_RS05070	COG0215	cysteine-tRNA ligase activity
GKP14_RS05075	COG1045	serine acetyltransferase
GKP14_RS05080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GKP14_RS05085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKP14_RS05090	COG2137	regulation of response to DNA damage stimulus
GKP14_RS05095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GKP14_RS05100	COG2217	Heavy metal translocating P-type atpase
GKP14_RS05110	COG2217	Heavy metal translocating P-type atpase
GKP14_RS05115	COG1937	Protein conserved in bacteria
GKP14_RS05140	COG1968	undecaprenyl-diphosphatase activity
GKP14_RS05145	COG1620	l-lactate permease
GKP14_RS05150	COG3875	lactate racemase activity
GKP14_RS05155	COG0277	FAD linked oxidase domain protein
GKP14_RS05165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GKP14_RS05170	COG1960	acyl-CoA dehydrogenase activity
GKP14_RS05175	COG0717	Belongs to the dCTP deaminase family
GKP14_RS05190	COG1269	ATP hydrolysis coupled proton transport
GKP14_RS05195	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKP14_RS05210	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
GKP14_RS05215	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GKP14_RS05220	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
GKP14_RS05225	COG1394	ATPase activity, coupled to movement of substances
GKP14_RS05230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GKP14_RS05235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GKP14_RS05245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GKP14_RS05250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GKP14_RS05255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GKP14_RS05265	COG0409	Hydrogenase expression formation protein
GKP14_RS05275	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GKP14_RS05285	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GKP14_RS05290	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GKP14_RS05295	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GKP14_RS05305	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GKP14_RS05315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GKP14_RS05320	COG0396	ATPase activity
GKP14_RS05325	COG0719	Fe-S assembly protein
GKP14_RS05330	COG0719	Fe-S assembly protein
GKP14_RS05335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GKP14_RS05340	COG0822	iron-sulfur transferase activity
GKP14_RS05350	COG0572	uridine kinase
GKP14_RS05360	COG1940	carbohydrate kinase activity
GKP14_RS05365	COG1482	cell wall glycoprotein biosynthetic process
GKP14_RS05370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKP14_RS05375	COG0366	Alpha amylase catalytic
GKP14_RS05395	COG1609	Transcriptional regulator
GKP14_RS05405	COG1554	hydrolase, family 65, central catalytic
GKP14_RS05415	COG1175	transmembrane transport
GKP14_RS05420	COG0395	ABC-type sugar transport system, permease component
GKP14_RS05425	COG1501	Belongs to the glycosyl hydrolase 31 family
GKP14_RS05430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKP14_RS05460	COG2801	Transposase and inactivated derivatives
GKP14_RS05470	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GKP14_RS05470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKP14_RS05470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKP14_RS05475	COG1461	Dihydroxyacetone kinase
GKP14_RS05480	COG2376	Dihydroxyacetone kinase
GKP14_RS05490	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GKP14_RS05505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GKP14_RS05510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKP14_RS05515	COG0446	pyridine nucleotide-disulphide oxidoreductase
GKP14_RS05530	COG3906	Belongs to the UPF0473 family
GKP14_RS05535	COG0281	malic enzyme
GKP14_RS05550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKP14_RS05555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKP14_RS05560	COG0284	orotidine-5'-phosphate decarboxylase activity
GKP14_RS05565	COG0543	2 iron, 2 sulfur cluster binding
GKP14_RS05570	COG0167	dihydroorotate dehydrogenase activity
GKP14_RS05575	COG0588	phosphoglycerate mutase activity
GKP14_RS05580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GKP14_RS05595	COG0768	penicillin binding
GKP14_RS05605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GKP14_RS05615	COG1116	anion transmembrane transporter activity
GKP14_RS05625	COG1725	Transcriptional regulator
GKP14_RS05630	COG1131	(ABC) transporter
GKP14_RS05640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GKP14_RS05660	COG4120	Belongs to the binding-protein-dependent transport system permease family
GKP14_RS05665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GKP14_RS05675	COG4475	Protein of unknown function (DUF436)
GKP14_RS05700	COG1126	abc transporter atp-binding protein
GKP14_RS05720	COG0254	rRNA binding
GKP14_RS05725	COG1739	Uncharacterized protein family UPF0029
GKP14_RS05730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GKP14_RS05735	COG0358	DNA primase activity
GKP14_RS05740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKP14_RS05745	COG1959	2 iron, 2 sulfur cluster binding
GKP14_RS05750	COG0085	RNA polymerase activity
GKP14_RS05755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GKP14_RS05760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GKP14_RS05765	COG0049	tRNA binding
GKP14_RS05770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GKP14_RS05775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GKP14_RS05790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GKP14_RS05800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GKP14_RS05815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKP14_RS05830	COG0052	Belongs to the universal ribosomal protein uS2 family
GKP14_RS05835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GKP14_RS05850	COG1278	Cold shock
GKP14_RS05880	COG1695	Transcriptional regulator
GKP14_RS05915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GKP14_RS05920	COG0482	sulfurtransferase activity
GKP14_RS05925	COG1691	(AIR) carboxylase
GKP14_RS05940	COG1959	2 iron, 2 sulfur cluster binding
GKP14_RS05950	COG1573	uracil-dna glycosylase
GKP14_RS05955	COG0426	domain, Protein
GKP14_RS05960	COG1960	acyl-CoA dehydrogenase activity
GKP14_RS05975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GKP14_RS05980	COG4684	Psort location CytoplasmicMembrane, score
GKP14_RS05985	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GKP14_RS05990	COG0577	efflux transmembrane transporter activity
GKP14_RS05995	COG1136	(ABC) transporter
GKP14_RS06000	COG5002	protein histidine kinase activity
GKP14_RS06005	COG0745	RESPONSE REGULATOR receiver
GKP14_RS06010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GKP14_RS06015	COG4608	Belongs to the ABC transporter superfamily
GKP14_RS06020	COG0444	Belongs to the ABC transporter superfamily
GKP14_RS06025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKP14_RS06030	COG0601	transmembrane transport
GKP14_RS06035	COG4166	transmembrane transport
GKP14_RS06040	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GKP14_RS06075	COG0513	Belongs to the DEAD box helicase family
GKP14_RS06110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GKP14_RS06115	COG0632	four-way junction helicase activity
GKP14_RS06120	COG2255	four-way junction helicase activity
GKP14_RS06125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKP14_RS06130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GKP14_RS06130	COG0116	Belongs to the methyltransferase superfamily
GKP14_RS06140	COG1122	ATPase activity
GKP14_RS06145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GKP14_RS06150	COG0101	tRNA pseudouridine synthase activity
GKP14_RS06165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GKP14_RS06210	COG2207	Transcriptional regulator
GKP14_RS06215	COG0210	DNA helicase
GKP14_RS06230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GKP14_RS06240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GKP14_RS06245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GKP14_RS06255	COG0768	penicillin binding
GKP14_RS06260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GKP14_RS06265	COG0537	adenosine 5'-monophosphoramidase activity
GKP14_RS06270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GKP14_RS06285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GKP14_RS06295	COG1522	sequence-specific DNA binding
GKP14_RS06300	COG3579	cysteine-type endopeptidase activity
GKP14_RS06315	COG0393	Putative heavy-metal-binding
GKP14_RS06335	COG1191	sigma factor activity
GKP14_RS06340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKP14_RS06355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GKP14_RS06360	COG0006	proline dipeptidase activity
GKP14_RS06365	COG0700	Nucleoside recognition
GKP14_RS06370	COG2715	membrane protein required for spore maturation
GKP14_RS06375	COG2002	toxin-antitoxin pair type II binding
GKP14_RS06390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GKP14_RS06395	COG0668	transmembrane transport
GKP14_RS06405	COG4481	Protein conserved in bacteria
GKP14_RS06410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GKP14_RS06415	COG0009	L-threonylcarbamoyladenylate synthase
GKP14_RS06420	COG0237	dephospho-CoA kinase activity
GKP14_RS06425	COG0741	lytic transglycosylase activity
GKP14_RS06430	COG1362	aminopeptidase activity
GKP14_RS06435	COG1979	alcohol dehydrogenase
GKP14_RS06445	COG1959	2 iron, 2 sulfur cluster binding
GKP14_RS06450	COG0745	RESPONSE REGULATOR receiver
GKP14_RS06455	COG5002	protein histidine kinase activity
GKP14_RS06460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GKP14_RS06470	COG1686	Belongs to the peptidase S11 family
GKP14_RS06475	COG2205	protein histidine kinase activity
GKP14_RS06480	COG0745	RESPONSE REGULATOR receiver
GKP14_RS06485	COG2409	Drug exporters of the RND superfamily
GKP14_RS06500	COG2172	sigma factor antagonist activity
GKP14_RS06505	COG1191	sigma factor activity
GKP14_RS06685	COG1175	transmembrane transport
GKP14_RS06690	COG3833	ABC-type maltose transport systems, permease component
GKP14_RS06695	COG2182	Extracellular solute-binding protein
GKP14_RS06710	COG0372	Belongs to the citrate synthase family
GKP14_RS06720	COG0540	Belongs to the ATCase OTCase family
GKP14_RS06730	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GKP14_RS06735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GKP14_RS06740	COG0573	inorganic phosphate transmembrane transporter activity
GKP14_RS06745	COG0581	inorganic phosphate transmembrane transporter activity
GKP14_RS06750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GKP14_RS06755	COG0704	Plays a role in the regulation of phosphate uptake
GKP14_RS06760	COG0745	RESPONSE REGULATOR receiver
GKP14_RS06765	COG5002	protein histidine kinase activity
GKP14_RS06775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GKP14_RS06780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GKP14_RS06785	COG1323	Belongs to the UPF0348 family
GKP14_RS06795	COG2848	UPF0210 protein
GKP14_RS06805	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GKP14_RS06810	COG1522	sequence-specific DNA binding
GKP14_RS06815	COG0436	Aminotransferase
GKP14_RS06820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GKP14_RS06835	COG0697	spore germination
GKP14_RS06840	COG0772	Belongs to the SEDS family
GKP14_RS06845	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GKP14_RS06855	COG1214	PFAM Peptidase M22, glycoprotease
GKP14_RS06860	COG0698	ribose 5-phosphate isomerase
GKP14_RS06870	COG0646	methionine synthase
GKP14_RS06870	COG1410	methionine synthase
GKP14_RS06880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GKP14_RS06890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GKP14_RS06890	COG0644	oxidoreductase
GKP14_RS06915	COG3854	ATPases associated with a variety of cellular activities
GKP14_RS06955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKP14_RS06960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GKP14_RS06965	COG1570	exodeoxyribonuclease VII activity
GKP14_RS06970	COG1722	exodeoxyribonuclease VII activity
GKP14_RS06975	COG2226	methyltransferase
GKP14_RS06985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GKP14_RS07000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GKP14_RS07005	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GKP14_RS07010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GKP14_RS07020	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GKP14_RS07020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GKP14_RS07025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GKP14_RS07030	COG0564	pseudouridine synthase activity
GKP14_RS07040	COG1854	S-ribosylhomocysteine lyase activity
GKP14_RS07050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKP14_RS07055	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GKP14_RS07065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GKP14_RS07070	COG0436	Aminotransferase
GKP14_RS07080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GKP14_RS07085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GKP14_RS07090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GKP14_RS07095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GKP14_RS07100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GKP14_RS07105	COG0519	Catalyzes the synthesis of GMP from XMP
GKP14_RS07135	COG1131	(ABC) transporter
GKP14_RS07165	COG0583	DNA-binding transcription factor activity
GKP14_RS07195	COG0110	maltose O-acetyltransferase activity
GKP14_RS07215	COG0561	phosphatase activity
GKP14_RS07225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GKP14_RS07235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GKP14_RS07245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GKP14_RS07250	COG3958	Transketolase
GKP14_RS07260	COG4536	flavin adenine dinucleotide binding
GKP14_RS07270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GKP14_RS07280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GKP14_RS07285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GKP14_RS07320	COG0460	homoserine dehydrogenase
GKP14_RS07325	COG0083	homoserine kinase activity
GKP14_RS07335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKP14_RS07345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GKP14_RS07355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKP14_RS07365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GKP14_RS07370	COG1799	cell septum assembly
GKP14_RS07385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GKP14_RS07390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GKP14_RS07395	COG0564	pseudouridine synthase activity
GKP14_RS07440	COG0798	PFAM Bile acid sodium symporter
GKP14_RS07445	COG0640	Transcriptional regulator
GKP14_RS07450	COG0446	pyridine nucleotide-disulphide oxidoreductase
GKP14_RS07470	COG2226	methyltransferase
GKP14_RS07480	COG0789	Transcriptional regulator
GKP14_RS07485	COG0390	transport system, permease component
GKP14_RS07490	COG4619	ABC transporter
GKP14_RS07505	COG0586	Pfam SNARE associated Golgi protein
GKP14_RS07510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GKP14_RS07535	COG2217	Heavy metal translocating P-type atpase
GKP14_RS07600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GKP14_RS07625	COG0270	DNA (cytosine-5-)-methyltransferase activity
GKP14_RS07710	COG2088	sporulation resulting in formation of a cellular spore
GKP14_RS07785	COG1773	rubredoxin
GKP14_RS07785	COG1592	Rubrerythrin
GKP14_RS07795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GKP14_RS07800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GKP14_RS07810	COG1216	Glycosyl transferase, family 2
GKP14_RS07815	COG2081	HI0933 family
GKP14_RS07820	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GKP14_RS07840	COG1686	Belongs to the peptidase S11 family
GKP14_RS07860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GKP14_RS07865	COG1160	GTP binding
GKP14_RS07870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GKP14_RS07875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GKP14_RS07880	COG1994	Peptidase M50
GKP14_RS07885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GKP14_RS07890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GKP14_RS07900	COG3874	Sporulation protein YtfJ
GKP14_RS07905	COG1686	Belongs to the peptidase S11 family
GKP14_RS07910	COG1187	pseudouridine synthase activity
GKP14_RS07915	COG1561	YicC-like family, N-terminal region
GKP14_RS07920	COG2052	Domain of unknown function (DUF370)
GKP14_RS07925	COG0194	GDP metabolic process
GKP14_RS07930	COG1758	RNA polymerase activity
GKP14_RS07935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GKP14_RS07940	COG0242	peptide deformylase activity
GKP14_RS07945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GKP14_RS07950	COG2738	Putative neutral zinc metallopeptidase
GKP14_RS07955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKP14_RS07955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GKP14_RS07960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GKP14_RS07965	COG0631	protein serine/threonine phosphatase activity
GKP14_RS07970	COG2815	serine threonine protein kinase
GKP14_RS07970	COG0515	serine threonine protein kinase
GKP14_RS07975	COG1162	GTPase activity
GKP14_RS07995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GKP14_RS08005	COG0493	'glutamate synthase
GKP14_RS08015	COG0517	IMP dehydrogenase activity
GKP14_RS08015	COG1994	Peptidase M50
GKP14_RS08030	COG0740	serine-type endopeptidase activity
GKP14_RS08035	COG1674	ftsk spoiiie
GKP14_RS08050	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GKP14_RS08055	COG1074	ATP-dependent DNA helicase activity
GKP14_RS08060	COG0335	large ribosomal subunit rRNA binding
GKP14_RS08075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GKP14_RS08080	COG0792	nuclease activity
GKP14_RS08085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GKP14_RS08095	COG0544	peptidyl-prolyl cis-trans isomerase activity
GKP14_RS08100	COG0740	serine-type endopeptidase activity
GKP14_RS08105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GKP14_RS08115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GKP14_RS08120	COG0019	diaminopimelate decarboxylase activity
GKP14_RS08125	COG4496	protein, YerC YecD
GKP14_RS08130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GKP14_RS08165	COG0534	Mate efflux family protein
GKP14_RS08170	COG0860	N-Acetylmuramoyl-L-alanine amidase
GKP14_RS08175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GKP14_RS08185	COG4974	Belongs to the 'phage' integrase family
GKP14_RS08195	COG4974	Belongs to the 'phage' integrase family
GKP14_RS08205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GKP14_RS08250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GKP14_RS08255	COG0527	aspartate kinase activity
GKP14_RS08275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GKP14_RS08325	COG1760	l-serine dehydratase
GKP14_RS08330	COG1760	l-serine dehydratase
GKP14_RS08340	COG0556	nucleotide-excision repair
GKP14_RS08345	COG2003	Belongs to the UPF0758 family
GKP14_RS08350	COG0564	pseudouridine synthase activity
GKP14_RS08360	COG0140	phosphoribosyl-ATP diphosphatase activity
GKP14_RS08365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GKP14_RS08370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GKP14_RS08375	COG0131	Imidazoleglycerol-phosphate dehydratase
GKP14_RS08380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GKP14_RS08385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GKP14_RS08390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GKP14_RS08395	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GKP14_RS08405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GKP14_RS08410	COG0750	zinc metalloprotease
GKP14_RS08420	COG4589	Belongs to the CDS family
GKP14_RS08430	COG0233	cytoplasmic translational termination
GKP14_RS08435	COG0528	UMP kinase activity
GKP14_RS08440	COG0385	Bile acid
GKP14_RS08455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKP14_RS08460	COG0217	transcriptional regulatory protein
GKP14_RS08470	COG0708	Exodeoxyribonuclease III
GKP14_RS08475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GKP14_RS08480	COG0515	serine threonine protein kinase
GKP14_RS08480	COG2815	serine threonine protein kinase
GKP14_RS08490	COG2195	Cleaves the N-terminal amino acid of tripeptides
GKP14_RS08515	COG4667	esterase of the alpha-beta hydrolase superfamily
GKP14_RS08525	COG0129	dihydroxy-acid dehydratase activity
GKP14_RS08530	COG0745	RESPONSE REGULATOR receiver
GKP14_RS08535	COG0750	zinc metalloprotease
GKP14_RS08550	COG1307	EDD domain protein, DegV family
GKP14_RS08555	COG0825	malonyl-CoA metabolic process
GKP14_RS08560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GKP14_RS08565	COG0439	Biotin carboxylase
GKP14_RS08575	COG0511	ligase activity, forming carbon-carbon bonds
GKP14_RS08580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GKP14_RS08590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GKP14_RS08595	COG2070	2-Nitropropane dioxygenase
GKP14_RS08600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKP14_RS08625	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GKP14_RS08640	COG0495	leucyl-tRNA aminoacylation
GKP14_RS08645	COG0799	negative regulation of ribosome biogenesis
GKP14_RS08650	COG1713	HD superfamily hydrolase involved in NAD metabolism
GKP14_RS08655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GKP14_RS08665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GKP14_RS08675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GKP14_RS08675	COG0539	negative regulation of cytoplasmic translation
GKP14_RS08685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GKP14_RS08690	COG2081	HI0933 family
GKP14_RS08705	COG0484	heat shock protein binding
GKP14_RS08715	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GKP14_RS08740	COG1683	Conserved Protein
GKP14_RS08745	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GKP14_RS08760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GKP14_RS08765	COG0552	protein localization to endoplasmic reticulum
GKP14_RS08770	COG1196	nuclear chromosome segregation
GKP14_RS08780	COG0571	ribonuclease III activity
GKP14_RS08785	COG0416	fatty acid biosynthetic process
GKP14_RS08795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKP14_RS08800	COG0758	DNA mediated transformation
GKP14_RS08800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GKP14_RS08805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKP14_RS08815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GKP14_RS08820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GKP14_RS08825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GKP14_RS08835	COG0538	isocitrate dehydrogenase activity
GKP14_RS08845	COG0504	CTP synthase activity
GKP14_RS08860	COG0539	negative regulation of cytoplasmic translation
GKP14_RS08865	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GKP14_RS08885	COG0613	PHP domain protein
GKP14_RS08890	COG0154	amidase activity
GKP14_RS08895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKP14_RS08900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GKP14_RS08905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKP14_RS08910	COG0813	purine-nucleoside phosphorylase activity
GKP14_RS08940	COG2124	cytochrome p450
GKP14_RS08955	COG1192	Involved in chromosome partitioning
GKP14_RS08985	COG1518	maintenance of DNA repeat elements