locus-tag	class	description
RGna_RS00015	COG1674	ftsk spoiiie
RGna_RS00045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RGna_RS00055	COG1316	TRANSCRIPTIONal
RGna_RS00060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RGna_RS00065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RGna_RS00075	COG1215	transferase activity, transferring glycosyl groups
RGna_RS00085	COG0438	transferase activity, transferring glycosyl groups
RGna_RS00090	COG1216	Glycosyl transferase, family 2
RGna_RS00095	COG1216	Glycosyl transferase, family 2
RGna_RS00095	COG1442	glycosyl transferase family 8
RGna_RS00120	COG0438	transferase activity, transferring glycosyl groups
RGna_RS00145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RGna_RS00170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RGna_RS00175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RGna_RS00180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RGna_RS00190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RGna_RS00195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RGna_RS00200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RGna_RS00210	COG1596	polysaccharide export
RGna_RS00210	COG1555	photosystem II stabilization
RGna_RS00215	COG0745	RESPONSE REGULATOR receiver
RGna_RS00220	COG5002	protein histidine kinase activity
RGna_RS00230	COG2333	competence protein COMEC
RGna_RS00230	COG0658	competence protein
RGna_RS00265	COG1401	restriction endodeoxyribonuclease activity
RGna_RS00355	COG2337	Toxic component of a toxin-antitoxin (TA) module
RGna_RS00380	COG0270	DNA (cytosine-5-)-methyltransferase activity
RGna_RS00415	COG4626	Terminase
RGna_RS00415	COG1802	Transcriptional regulator
RGna_RS00425	COG4695	Portal protein
RGna_RS00430	COG0740	serine-type endopeptidase activity
RGna_RS00475	COG2801	Transposase and inactivated derivatives
RGna_RS00510	COG0358	DNA primase activity
RGna_RS00635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RGna_RS00685	COG2721	sulfolactate sulfo-lyase activity
RGna_RS00690	COG1904	glucuronate isomerase
RGna_RS00710	COG1609	Transcriptional regulator
RGna_RS00730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGna_RS00740	COG0745	RESPONSE REGULATOR receiver
RGna_RS00745	COG5002	protein histidine kinase activity
RGna_RS00745	COG3850	Histidine kinase
RGna_RS00755	COG1420	regulation of RNA biosynthetic process
RGna_RS00760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RGna_RS00765	COG0443	Heat shock 70 kDa protein
RGna_RS00770	COG0484	heat shock protein binding
RGna_RS00785	COG0534	Mate efflux family protein
RGna_RS00790	COG1733	regulation of RNA biosynthetic process
RGna_RS00795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RGna_RS00800	COG4605	iron ion homeostasis
RGna_RS00805	COG4604	ABC transporter, ATP-binding protein
RGna_RS00820	COG0539	negative regulation of cytoplasmic translation
RGna_RS00840	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RGna_RS00850	COG0726	polysaccharide deacetylase
RGna_RS00855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RGna_RS00860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RGna_RS00870	COG1242	4 iron, 4 sulfur cluster binding
RGna_RS00875	COG0281	malic enzyme
RGna_RS00890	COG0254	rRNA binding
RGna_RS00895	COG3872	metal-dependent enzyme
RGna_RS00900	COG2890	protein-(glutamine-N5) methyltransferase activity
RGna_RS00905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RGna_RS00940	COG0436	Aminotransferase
RGna_RS00955	COG1396	sequence-specific DNA binding
RGna_RS00985	COG1959	2 iron, 2 sulfur cluster binding
RGna_RS00990	COG1959	2 iron, 2 sulfur cluster binding
RGna_RS01005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RGna_RS01030	COG1199	ATP-dependent helicase activity
RGna_RS01035	COG0583	DNA-binding transcription factor activity
RGna_RS01045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RGna_RS01065	COG2309	aminopeptidase activity
RGna_RS01085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RGna_RS01095	COG1045	serine acetyltransferase
RGna_RS01100	COG0215	cysteine-tRNA ligase activity
RGna_RS01110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGna_RS01135	COG1490	D-aminoacyl-tRNA deacylase activity
RGna_RS01150	COG3681	Belongs to the UPF0597 family
RGna_RS01155	COG1595	DNA-templated transcription, initiation
RGna_RS01170	COG0733	neurotransmitter:sodium symporter activity
RGna_RS01180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGna_RS01190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RGna_RS01195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RGna_RS01205	COG0653	protein targeting
RGna_RS01215	COG0656	L-ascorbic acid biosynthetic process
RGna_RS01230	COG0628	permease
RGna_RS01235	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RGna_RS01245	COG0436	Aminotransferase
RGna_RS01255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RGna_RS01255	COG1328	CTP reductase activity
RGna_RS01260	COG0602	queuosine metabolic process
RGna_RS01265	COG0756	dUTP diphosphatase activity
RGna_RS01270	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RGna_RS01275	COG0697	spore germination
RGna_RS01285	COG0733	neurotransmitter:sodium symporter activity
RGna_RS01300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RGna_RS01325	COG0534	Mate efflux family protein
RGna_RS01335	COG0358	DNA primase activity
RGna_RS01340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RGna_RS01345	COG2384	SAM-dependent methyltransferase
RGna_RS01355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RGna_RS01360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RGna_RS01365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RGna_RS01370	COG1176	ABC-type spermidine putrescine transport system, permease component I
RGna_RS01390	COG0343	queuine tRNA-ribosyltransferase activity
RGna_RS01400	COG0473	3-isopropylmalate dehydrogenase activity
RGna_RS01405	COG0129	dihydroxy-acid dehydratase activity
RGna_RS01410	COG0028	Belongs to the TPP enzyme family
RGna_RS01415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RGna_RS01420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RGna_RS01425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RGna_RS01430	COG1802	Transcriptional regulator
RGna_RS01435	COG0538	isocitrate dehydrogenase activity
RGna_RS01440	COG1595	DNA-templated transcription, initiation
RGna_RS01450	COG0488	(ABC) transporter
RGna_RS01455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
RGna_RS01460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RGna_RS01460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RGna_RS01470	COG2337	Toxic component of a toxin-antitoxin (TA) module
RGna_RS01475	COG0217	transcriptional regulatory protein
RGna_RS01485	COG2873	o-acetylhomoserine
RGna_RS01490	COG0740	serine-type endopeptidase activity
RGna_RS01505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RGna_RS01525	COG0493	'glutamate synthase
RGna_RS01535	COG1114	Component of the transport system for branched-chain amino acids
RGna_RS01550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RGna_RS01630	COG1309	transcriptional regulator
RGna_RS01640	COG1132	(ABC) transporter
RGna_RS01650	COG0534	Mate efflux family protein
RGna_RS01690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RGna_RS01705	COG0237	dephospho-CoA kinase activity
RGna_RS01710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RGna_RS01720	COG2848	UPF0210 protein
RGna_RS01725	COG1307	EDD domain protein, DegV family
RGna_RS01735	COG5002	protein histidine kinase activity
RGna_RS01740	COG0577	efflux transmembrane transporter activity
RGna_RS01745	COG0577	efflux transmembrane transporter activity
RGna_RS01750	COG1136	(ABC) transporter
RGna_RS01815	COG4509	Sortase family
RGna_RS01835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RGna_RS01885	COG0791	NLP P60 protein
RGna_RS01885	COG0741	lytic transglycosylase activity
RGna_RS01890	COG2315	Protein conserved in bacteria
RGna_RS01905	COG5002	protein histidine kinase activity
RGna_RS01910	COG0745	RESPONSE REGULATOR receiver
RGna_RS01945	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
RGna_RS01970	COG2239	Acts as a magnesium transporter
RGna_RS01990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RGna_RS01995	COG0416	fatty acid biosynthetic process
RGna_RS02000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RGna_RS02005	COG0571	ribonuclease III activity
RGna_RS02010	COG1196	nuclear chromosome segregation
RGna_RS02015	COG0552	protein localization to endoplasmic reticulum
RGna_RS02020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RGna_RS02075	COG1160	GTP binding
RGna_RS02080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RGna_RS02100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RGna_RS02110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RGna_RS02115	COG4989	oxidoreductase activity
RGna_RS02125	COG0540	Belongs to the ATCase OTCase family
RGna_RS02150	COG1605	Chorismate mutase
RGna_RS02150	COG0077	Prephenate dehydratase
RGna_RS02170	COG1561	YicC-like family, N-terminal region
RGna_RS02175	COG0194	GDP metabolic process
RGna_RS02180	COG1758	RNA polymerase activity
RGna_RS02185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RGna_RS02345	COG0582	viral genome integration into host DNA
RGna_RS02355	COG0776	regulation of translation
RGna_RS02400	COG0210	DNA helicase
RGna_RS02415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RGna_RS02545	COG4974	Belongs to the 'phage' integrase family
RGna_RS02565	COG3550	peptidyl-serine autophosphorylation
RGna_RS02610	COG2337	Toxic component of a toxin-antitoxin (TA) module
RGna_RS02655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RGna_RS02675	COG0194	GDP metabolic process
RGna_RS02715	COG0756	dUTP diphosphatase activity
RGna_RS02740	COG1435	thymidine kinase activity
RGna_RS02755	COG2226	methyltransferase
RGna_RS02760	COG3973	AAA domain
RGna_RS02780	COG3279	Response regulator of the LytR AlgR family
RGna_RS02790	COG4377	Putative membrane peptidase family (DUF2324)
RGna_RS02830	COG2252	PERMEase
RGna_RS02845	COG1297	OPT oligopeptide transporter protein
RGna_RS02850	COG2195	Cleaves the N-terminal amino acid of tripeptides
RGna_RS02865	COG1702	phosphate starvation-inducible protein PhoH
RGna_RS02875	COG2244	polysaccharide biosynthetic process
RGna_RS02885	COG4224	UPF0291 protein
RGna_RS02900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RGna_RS02905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RGna_RS02910	COG1120	ATPase activity
RGna_RS02915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RGna_RS02925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RGna_RS02935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RGna_RS02940	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
RGna_RS02945	COG2081	HI0933 family
RGna_RS02950	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RGna_RS02975	COG0768	penicillin binding
RGna_RS02985	COG2894	cell division
RGna_RS02995	COG0772	Belongs to the SEDS family
RGna_RS03000	COG1803	Methylglyoxal synthase
RGna_RS03005	COG1686	Belongs to the peptidase S11 family
RGna_RS03010	COG2155	Conserved Protein
RGna_RS03020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RGna_RS03025	COG1799	cell septum assembly
RGna_RS03040	COG0564	pseudouridine synthase activity
RGna_RS03050	COG0328	RNA-DNA hybrid ribonuclease activity
RGna_RS03065	COG0037	tRNA processing
RGna_RS03075	COG0667	Aldo Keto reductase
RGna_RS03090	COG1388	LysM domain
RGna_RS03095	COG1132	(ABC) transporter
RGna_RS03105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RGna_RS03110	COG0799	negative regulation of ribosome biogenesis
RGna_RS03115	COG1713	HD superfamily hydrolase involved in NAD metabolism
RGna_RS03120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RGna_RS03125	COG1534	Rna-binding protein
RGna_RS03130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RGna_RS03135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RGna_RS03150	COG0517	IMP dehydrogenase activity
RGna_RS03150	COG1125	glycine betaine transport
RGna_RS03155	COG0527	aspartate kinase activity
RGna_RS03160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RGna_RS03165	COG1530	ribonuclease E activity
RGna_RS03195	COG0534	Mate efflux family protein
RGna_RS03200	COG2268	Band 7 protein
RGna_RS03205	COG3835	regulator
RGna_RS03210	COG2610	gluconate transmembrane transporter activity
RGna_RS03215	COG1929	Belongs to the glycerate kinase type-1 family
RGna_RS03255	COG1674	ftsk spoiiie
RGna_RS03265	COG2946	Replication initiation factor
RGna_RS03315	COG0741	lytic transglycosylase activity
RGna_RS03315	COG0791	NLP P60 protein
RGna_RS03340	COG2205	protein histidine kinase activity
RGna_RS03355	COG0745	RESPONSE REGULATOR receiver
RGna_RS03390	COG1966	Carbon starvation protein
RGna_RS03395	COG1454	alcohol dehydrogenase
RGna_RS03410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS03410	COG2190	(PTS) system
RGna_RS03410	COG1263	PTS System
RGna_RS03435	COG4716	Myosin-crossreactive antigen
RGna_RS03440	COG1309	transcriptional regulator
RGna_RS03460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RGna_RS03480	COG0131	Imidazoleglycerol-phosphate dehydratase
RGna_RS03485	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RGna_RS03490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RGna_RS03500	COG3331	DNA recombination
RGna_RS03505	COG0564	pseudouridine synthase activity
RGna_RS03530	COG1187	pseudouridine synthase activity
RGna_RS03535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RGna_RS03535	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
RGna_RS03555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RGna_RS03560	COG0742	ribosomal rna small subunit methyltransferase
RGna_RS03570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RGna_RS03575	COG1461	Dihydroxyacetone kinase
RGna_RS03590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RGna_RS03610	COG0768	penicillin binding
RGna_RS03615	COG0772	Belongs to the SEDS family
RGna_RS03620	COG0826	peptidase U32
RGna_RS03630	COG2255	four-way junction helicase activity
RGna_RS03635	COG0632	four-way junction helicase activity
RGna_RS03650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RGna_RS03720	COG4978	Transcriptional regulator
RGna_RS03720	COG0789	Transcriptional regulator
RGna_RS03725	COG1245	4Fe-4S binding domain
RGna_RS03725	COG2878	Part of a membrane complex involved in electron transport
RGna_RS03730	COG4657	Part of a membrane complex involved in electron transport
RGna_RS03735	COG4660	Part of a membrane complex involved in electron transport
RGna_RS03745	COG4658	electron transport chain
RGna_RS03750	COG4656	Part of a membrane complex involved in electron transport
RGna_RS03755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RGna_RS03755	COG0539	negative regulation of cytoplasmic translation
RGna_RS03760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RGna_RS03765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RGna_RS03770	COG2081	HI0933 family
RGna_RS03775	COG1737	Transcriptional regulator
RGna_RS03780	COG0006	proline dipeptidase activity
RGna_RS03790	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
RGna_RS03805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RGna_RS03810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RGna_RS03815	COG1686	Belongs to the peptidase S11 family
RGna_RS03820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RGna_RS03830	COG1408	metallophosphoesterase
RGna_RS03835	COG1686	Belongs to the peptidase S11 family
RGna_RS03850	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RGna_RS03855	COG1379	DNA repair
RGna_RS03860	COG0484	heat shock protein binding
RGna_RS03900	COG4974	Belongs to the 'phage' integrase family
RGna_RS03915	COG0433	COG0433 Predicted ATPase
RGna_RS03950	COG0494	nUDIX hydrolase
RGna_RS03960	COG1126	abc transporter atp-binding protein
RGna_RS03965	COG0765	amino acid transport
RGna_RS03970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGna_RS03975	COG4810	utilization protein
RGna_RS03980	COG4810	utilization protein
RGna_RS03990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RGna_RS04005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RGna_RS04010	COG1760	l-serine dehydratase
RGna_RS04015	COG1760	l-serine dehydratase
RGna_RS04030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RGna_RS04040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RGna_RS04050	COG1410	methionine synthase
RGna_RS04050	COG0646	methionine synthase
RGna_RS04060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RGna_RS04065	COG0297	glycogen (starch) synthase activity
RGna_RS04070	COG0745	RESPONSE REGULATOR receiver
RGna_RS04075	COG0750	zinc metalloprotease
RGna_RS04080	COG0497	DNA recombination
RGna_RS04085	COG1438	arginine binding
RGna_RS04090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RGna_RS04095	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RGna_RS04100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RGna_RS04110	COG1722	exodeoxyribonuclease VII activity
RGna_RS04115	COG1570	exodeoxyribonuclease VII activity
RGna_RS04125	COG1302	Protein conserved in bacteria
RGna_RS04130	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RGna_RS04170	COG3854	ATPases associated with a variety of cellular activities
RGna_RS04180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RGna_RS04190	COG1131	(ABC) transporter
RGna_RS04195	COG2205	protein histidine kinase activity
RGna_RS04200	COG0745	RESPONSE REGULATOR receiver
RGna_RS04205	COG0148	phosphopyruvate hydratase activity
RGna_RS04215	COG1136	(ABC) transporter
RGna_RS04220	COG0577	efflux transmembrane transporter activity
RGna_RS04255	COG0688	phosphatidylethanolamine metabolic process
RGna_RS04260	COG1183	phosphatidylcholine synthase activity
RGna_RS04280	COG1185	polyribonucleotide nucleotidyltransferase activity
RGna_RS04285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RGna_RS04305	COG1175	transmembrane transport
RGna_RS04320	COG2207	Transcriptional regulator
RGna_RS04320	COG4753	response regulator
RGna_RS04325	COG2972	Histidine kinase
RGna_RS04330	COG0196	riboflavin kinase activity
RGna_RS04335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RGna_RS04340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RGna_RS04345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RGna_RS04350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RGna_RS04350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RGna_RS04360	COG2740	Nucleic-acid-binding protein implicated in transcription termination
RGna_RS04365	COG0195	Participates in both transcription termination and antitermination
RGna_RS04370	COG0779	Required for maturation of 30S ribosomal subunits
RGna_RS04375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RGna_RS04380	COG0187	DNA topoisomerase II activity
RGna_RS04390	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RGna_RS04395	COG0268	Binds directly to 16S ribosomal RNA
RGna_RS04405	COG3711	transcriptional antiterminator
RGna_RS04410	COG1263	PTS System
RGna_RS04410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS04410	COG2190	(PTS) system
RGna_RS04415	COG0534	Mate efflux family protein
RGna_RS04425	COG0440	acetolactate synthase activity
RGna_RS04435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGna_RS04445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RGna_RS04460	COG0488	(ABC) transporter
RGna_RS04465	COG2205	protein histidine kinase activity
RGna_RS04470	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RGna_RS04475	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RGna_RS04495	COG1028	Short-chain dehydrogenase reductase Sdr
RGna_RS04515	COG0745	RESPONSE REGULATOR receiver
RGna_RS04520	COG2205	protein histidine kinase activity
RGna_RS04525	COG1312	Catalyzes the dehydration of D-mannonate
RGna_RS04555	COG1609	Transcriptional regulator
RGna_RS04575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGna_RS04580	COG1126	abc transporter atp-binding protein
RGna_RS04590	COG1686	Belongs to the peptidase S11 family
RGna_RS04600	COG1309	transcriptional regulator
RGna_RS04605	COG1307	EDD domain protein, DegV family
RGna_RS04630	COG2610	gluconate transmembrane transporter activity
RGna_RS04660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RGna_RS04665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RGna_RS04675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RGna_RS04680	COG0745	RESPONSE REGULATOR receiver
RGna_RS04685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RGna_RS04690	COG0149	triose-phosphate isomerase activity
RGna_RS04705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RGna_RS04710	COG0482	sulfurtransferase activity
RGna_RS04715	COG0822	iron-sulfur transferase activity
RGna_RS04725	COG1959	2 iron, 2 sulfur cluster binding
RGna_RS04745	COG1418	mRNA catabolic process
RGna_RS04750	COG2137	regulation of response to DNA damage stimulus
RGna_RS04785	COG1803	Methylglyoxal synthase
RGna_RS04800	COG2084	Dehydrogenase
RGna_RS04805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RGna_RS04810	COG0551	DNA topoisomerase type I activity
RGna_RS04810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RGna_RS04825	COG0488	(ABC) transporter
RGna_RS04830	COG0406	alpha-ribazole phosphatase activity
RGna_RS04835	COG1854	S-ribosylhomocysteine lyase activity
RGna_RS04840	COG2364	Membrane
RGna_RS04850	COG1523	belongs to the glycosyl hydrolase 13 family
RGna_RS04855	COG1879	ABC-type sugar transport system periplasmic component
RGna_RS04860	COG3906	Belongs to the UPF0473 family
RGna_RS04865	COG0210	DNA helicase
RGna_RS04870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RGna_RS04880	COG2966	Psort location CytoplasmicMembrane, score
RGna_RS04895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RGna_RS04900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RGna_RS04910	COG1105	Belongs to the carbohydrate kinase PfkB family
RGna_RS04915	COG1349	DNA-binding transcription factor activity
RGna_RS04955	COG0714	Associated with various cellular activities
RGna_RS04975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RGna_RS04980	COG0193	aminoacyl-tRNA hydrolase activity
RGna_RS04995	COG0546	phosphoglycolate phosphatase activity
RGna_RS05000	COG1191	sigma factor activity
RGna_RS05010	COG1191	sigma factor activity
RGna_RS05020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RGna_RS05030	COG0772	Belongs to the SEDS family
RGna_RS05035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RGna_RS05045	COG0768	penicillin binding
RGna_RS05050	COG0768	penicillin binding
RGna_RS05075	COG1307	EDD domain protein, DegV family
RGna_RS05080	COG0772	Belongs to the SEDS family
RGna_RS05085	COG0367	asparagine synthase
RGna_RS05135	COG1674	ftsk spoiiie
RGna_RS05140	COG2946	Replication initiation factor
RGna_RS05225	COG0488	(ABC) transporter
RGna_RS05275	COG3706	GGDEF domain
RGna_RS05275	COG0745	RESPONSE REGULATOR receiver
RGna_RS05290	COG2205	protein histidine kinase activity
RGna_RS05305	COG0745	RESPONSE REGULATOR receiver
RGna_RS05320	COG2226	methyltransferase
RGna_RS05350	COG0495	leucyl-tRNA aminoacylation
RGna_RS05355	COG1115	amino acid carrier protein
RGna_RS05390	COG0569	domain protein
RGna_RS05395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RGna_RS05400	COG0287	Prephenate dehydrogenase
RGna_RS05405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RGna_RS05410	COG2188	Transcriptional regulator
RGna_RS05415	COG2233	PERMEase
RGna_RS05430	COG1937	Protein conserved in bacteria
RGna_RS05440	COG1966	Carbon starvation protein
RGna_RS05470	COG1648	precorrin-2 dehydrogenase activity
RGna_RS05470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RGna_RS05495	COG4172	Belongs to the ABC transporter superfamily
RGna_RS05500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGna_RS05505	COG0601	transmembrane transport
RGna_RS05525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RGna_RS05540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RGna_RS05545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RGna_RS05550	COG1797	cobyrinic acid a,c-diamide synthase activity
RGna_RS05555	COG2242	protein methyltransferase activity
RGna_RS05565	COG2875	Belongs to the precorrin methyltransferase family
RGna_RS05580	COG4822	anaerobic cobalamin biosynthetic process
RGna_RS05600	COG0310	cobalt ion transport
RGna_RS05605	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RGna_RS05620	COG0004	ammonium transporteR
RGna_RS05625	COG0347	Belongs to the P(II) protein family
RGna_RS05630	COG3858	chitin binding
RGna_RS05630	COG1388	LysM domain
RGna_RS05640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGna_RS05640	COG0072	phenylalanine-tRNA ligase activity
RGna_RS05645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RGna_RS05650	COG1295	ribonuclease BN
RGna_RS05695	COG0165	Argininosuccinate lyase
RGna_RS05705	COG1116	anion transmembrane transporter activity
RGna_RS05710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RGna_RS05715	COG0733	neurotransmitter:sodium symporter activity
RGna_RS05720	COG1309	transcriptional regulator
RGna_RS05725	COG0534	Mate efflux family protein
RGna_RS05735	COG1940	carbohydrate kinase activity
RGna_RS05740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RGna_RS05745	COG0322	excinuclease ABC activity
RGna_RS05750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGna_RS05755	COG4868	Belongs to the UPF0371 family
RGna_RS05765	COG0671	phosphoesterase, PA-phosphatase related
RGna_RS05785	COG0534	Mate efflux family protein
RGna_RS05790	COG1132	(ABC) transporter
RGna_RS05795	COG1592	Rubrerythrin
RGna_RS05805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RGna_RS05810	COG0440	acetolactate synthase activity
RGna_RS05815	COG0028	Belongs to the TPP enzyme family
RGna_RS05820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RGna_RS05825	COG1121	(ABC) transporter
RGna_RS05830	COG0803	Belongs to the bacterial solute-binding protein 9 family
RGna_RS05845	COG0460	homoserine dehydrogenase
RGna_RS05860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RGna_RS05865	COG0124	histidyl-tRNA synthetase
RGna_RS05870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGna_RS05875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGna_RS05880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RGna_RS05895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGna_RS05895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGna_RS05900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RGna_RS05910	COG2002	toxin-antitoxin pair type II binding
RGna_RS05930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RGna_RS05935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RGna_RS05950	COG4978	Transcriptional regulator
RGna_RS05950	COG0789	Transcriptional regulator
RGna_RS05960	COG1392	Phosphate transport regulator
RGna_RS05965	COG0306	phosphate transporter
RGna_RS05970	COG0569	domain protein
RGna_RS05975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RGna_RS05980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGna_RS05980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGna_RS05990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RGna_RS05995	COG0574	Belongs to the PEP-utilizing enzyme family
RGna_RS05995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RGna_RS06000	COG1362	aminopeptidase activity
RGna_RS06010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RGna_RS06015	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RGna_RS06020	COG0423	glycine-tRNA ligase activity
RGna_RS06025	COG1381	Involved in DNA repair and RecF pathway recombination
RGna_RS06070	COG3833	ABC-type maltose transport systems, permease component
RGna_RS06075	COG1175	transmembrane transport
RGna_RS06090	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RGna_RS06095	COG1472	Belongs to the glycosyl hydrolase 3 family
RGna_RS06140	COG4608	Belongs to the ABC transporter superfamily
RGna_RS06145	COG0444	Belongs to the ABC transporter superfamily
RGna_RS06165	COG0601	transmembrane transport
RGna_RS06180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RGna_RS06185	COG0012	GTP binding
RGna_RS06190	COG0582	viral genome integration into host DNA
RGna_RS06200	COG1484	DNA-dependent DNA replication
RGna_RS06215	COG1136	(ABC) transporter
RGna_RS06215	COG0577	efflux transmembrane transporter activity
RGna_RS06220	COG5002	protein histidine kinase activity
RGna_RS06220	COG5000	phosphorelay sensor kinase activity
RGna_RS06225	COG0745	RESPONSE REGULATOR receiver
RGna_RS06240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RGna_RS06250	COG0515	serine threonine protein kinase
RGna_RS06250	COG2815	serine threonine protein kinase
RGna_RS06255	COG0631	protein serine/threonine phosphatase activity
RGna_RS06260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RGna_RS06265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RGna_RS06265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RGna_RS06270	COG2738	Putative neutral zinc metallopeptidase
RGna_RS06285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RGna_RS06300	COG0668	transmembrane transport
RGna_RS06310	COG0792	nuclease activity
RGna_RS06315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RGna_RS06320	COG0681	Belongs to the peptidase S26 family
RGna_RS06335	COG0335	large ribosomal subunit rRNA binding
RGna_RS06340	COG0336	Belongs to the RNA methyltransferase TrmD family
RGna_RS06345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RGna_RS06355	COG0228	four-way junction DNA binding
RGna_RS06360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RGna_RS06370	COG1404	Belongs to the peptidase S8 family
RGna_RS06615	COG0101	tRNA pseudouridine synthase activity
RGna_RS06680	COG1757	Na H antiporter
RGna_RS06685	COG0352	thiamine-phosphate diphosphorylase activity
RGna_RS06685	COG0351	phosphomethylpyrimidine kinase
RGna_RS06700	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RGna_RS06705	COG0367	asparagine synthase
RGna_RS06710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RGna_RS06720	COG0673	inositol 2-dehydrogenase activity
RGna_RS06730	COG2059	Chromate
RGna_RS06745	COG0395	ABC-type sugar transport system, permease component
RGna_RS06750	COG4209	transmembrane transport
RGna_RS06755	COG1609	Transcriptional regulator
RGna_RS06770	COG2169	Transcriptional regulator
RGna_RS06775	COG5426	von Willebrand factor, type A
RGna_RS06780	COG5002	protein histidine kinase activity
RGna_RS06785	COG0745	RESPONSE REGULATOR receiver
RGna_RS06790	COG1695	Transcriptional regulator
RGna_RS06805	COG0434	BtpA family
RGna_RS06825	COG1082	Xylose isomerase domain protein TIM barrel
RGna_RS06835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGna_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
RGna_RS06855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGna_RS06860	COG0363	glucosamine-6-phosphate deaminase activity
RGna_RS06875	COG0531	amino acid
RGna_RS06880	COG1070	Carbohydrate kinase
RGna_RS06890	COG2188	Transcriptional regulator
RGna_RS06895	COG0534	Mate efflux family protein
RGna_RS06900	COG1082	Xylose isomerase domain protein TIM barrel
RGna_RS06905	COG1082	Xylose isomerase domain protein TIM barrel
RGna_RS06910	COG0561	phosphatase activity
RGna_RS06915	COG1757	Na H antiporter
RGna_RS06920	COG0488	(ABC) transporter
RGna_RS06925	COG1393	Belongs to the ArsC family
RGna_RS06975	COG0577	efflux transmembrane transporter activity
RGna_RS07185	COG1475	DNA binding
RGna_RS07200	COG1192	Involved in chromosome partitioning
RGna_RS07320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RGna_RS07325	COG0542	response to heat
RGna_RS07335	COG1309	transcriptional regulator
RGna_RS07340	COG2195	Cleaves the N-terminal amino acid of tripeptides
RGna_RS07350	COG2816	NAD+ diphosphatase activity
RGna_RS07355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RGna_RS07370	COG0475	glutathione-regulated potassium exporter activity
RGna_RS07375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RGna_RS07385	COG1187	pseudouridine synthase activity
RGna_RS07410	COG2357	RelA SpoT domain protein
RGna_RS07440	COG0793	Belongs to the peptidase S41A family
RGna_RS07445	COG1196	nuclear chromosome segregation
RGna_RS07445	COG0741	lytic transglycosylase activity
RGna_RS07445	COG0739	heme binding
RGna_RS07450	COG2177	Part of the ABC transporter FtsEX involved in
RGna_RS07455	COG2884	Cell division ATP-binding protein ftsE
RGna_RS07460	COG3835	regulator
RGna_RS07505	COG1074	ATP-dependent DNA helicase activity
RGna_RS07510	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
RGna_RS07525	COG0657	acetylesterase activity
RGna_RS07525	COG2755	lipolytic protein G-D-S-L family
RGna_RS07535	COG0583	DNA-binding transcription factor activity
RGna_RS07560	COG3118	belongs to the thioredoxin family
RGna_RS07570	COG0768	penicillin binding
RGna_RS07600	COG1349	DNA-binding transcription factor activity
RGna_RS07625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RGna_RS07630	COG0295	cytidine deaminase activity
RGna_RS07640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGna_RS07675	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RGna_RS07680	COG0151	Belongs to the GarS family
RGna_RS07685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RGna_RS07690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RGna_RS07695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RGna_RS07720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RGna_RS07735	COG0583	DNA-binding transcription factor activity
RGna_RS07740	COG0167	dihydroorotate dehydrogenase activity
RGna_RS07745	COG0543	2 iron, 2 sulfur cluster binding
RGna_RS07750	COG0284	orotidine-5'-phosphate decarboxylase activity
RGna_RS07755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RGna_RS07770	COG2723	6-phospho-beta-galactosidase activity
RGna_RS07775	COG1263	PTS System
RGna_RS07775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS07775	COG2190	(PTS) system
RGna_RS07780	COG1737	Transcriptional regulator
RGna_RS07785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGna_RS07790	COG1115	amino acid carrier protein
RGna_RS07800	COG0484	heat shock protein binding
RGna_RS07815	COG0037	tRNA processing
RGna_RS07820	COG0300	oxidoreductase activity
RGna_RS07825	COG0582	viral genome integration into host DNA
RGna_RS07875	COG0577	efflux transmembrane transporter activity
RGna_RS07875	COG1136	(ABC) transporter
RGna_RS07940	COG2211	Major facilitator Superfamily
RGna_RS07945	COG2190	(PTS) system
RGna_RS07945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS07945	COG1263	PTS System
RGna_RS07950	COG3711	transcriptional antiterminator
RGna_RS07965	COG0116	Belongs to the methyltransferase superfamily
RGna_RS07990	COG0562	UDP-galactopyranose mutase
RGna_RS08000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RGna_RS08005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RGna_RS08035	COG5002	protein histidine kinase activity
RGna_RS08045	COG0242	peptide deformylase activity
RGna_RS08075	COG1597	lipid kinase activity
RGna_RS08085	COG1489	DNA binding
RGna_RS08095	COG1126	abc transporter atp-binding protein
RGna_RS08100	COG0765	amino acid transport
RGna_RS08105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGna_RS08115	COG0561	phosphatase activity
RGna_RS08120	COG3773	Cell wall hydrolase
RGna_RS08120	COG3409	Peptidoglycan-binding domain 1 protein
RGna_RS08130	COG1012	belongs to the aldehyde dehydrogenase family
RGna_RS08130	COG1454	alcohol dehydrogenase
RGna_RS08140	COG0203	ribosomal protein L17
RGna_RS08155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RGna_RS08165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RGna_RS08170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RGna_RS08180	COG0563	adenylate kinase activity
RGna_RS08185	COG0201	protein transport
RGna_RS08195	COG1841	ribosomal large subunit assembly
RGna_RS08200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RGna_RS08210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RGna_RS08215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RGna_RS08220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RGna_RS08235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RGna_RS08240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RGna_RS08245	COG0255	Belongs to the universal ribosomal protein uL29 family
RGna_RS08250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RGna_RS08260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RGna_RS08270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RGna_RS08275	COG0089	rRNA binding
RGna_RS08295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RGna_RS08295	COG0116	Belongs to the methyltransferase superfamily
RGna_RS08300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RGna_RS08315	COG0789	Transcriptional regulator
RGna_RS08325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGna_RS08330	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RGna_RS08335	COG4409	exo-alpha-(2->6)-sialidase activity
RGna_RS08340	COG0673	inositol 2-dehydrogenase activity
RGna_RS08355	COG1653	transport
RGna_RS08360	COG2207	Transcriptional regulator
RGna_RS08360	COG0662	Cupin 2, conserved barrel domain protein
RGna_RS08365	COG2731	YhcH YjgK YiaL family protein
RGna_RS08400	COG0534	Mate efflux family protein
RGna_RS08410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RGna_RS08415	COG3401	FG-GAP repeat protein
RGna_RS08420	COG1653	transport
RGna_RS08425	COG0395	ABC-type sugar transport system, permease component
RGna_RS08430	COG4209	transmembrane transport
RGna_RS08435	COG2207	Transcriptional regulator
RGna_RS08435	COG1917	Cupin 2, conserved barrel domain protein
RGna_RS08460	COG1609	Transcriptional regulator
RGna_RS08500	COG0058	SHG alpha-glucan phosphorylase activity
RGna_RS08510	COG1523	belongs to the glycosyl hydrolase 13 family
RGna_RS08515	COG3833	ABC-type maltose transport systems, permease component
RGna_RS08520	COG1175	transmembrane transport
RGna_RS08530	COG1609	Transcriptional regulator
RGna_RS08560	COG0439	Biotin carboxylase
RGna_RS08565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RGna_RS08575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RGna_RS08585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RGna_RS08590	COG2070	2-Nitropropane dioxygenase
RGna_RS08595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RGna_RS08600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RGna_RS08615	COG0534	Mate efflux family protein
RGna_RS08635	COG0484	heat shock protein binding
RGna_RS08670	COG0419	ATPase involved in DNA repair
RGna_RS08675	COG0420	3'-5' exonuclease activity
RGna_RS08705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RGna_RS08710	COG1481	regulation of sporulation
RGna_RS08720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RGna_RS08725	COG1253	flavin adenine dinucleotide binding
RGna_RS08740	COG0745	RESPONSE REGULATOR receiver
RGna_RS08750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RGna_RS08755	COG0561	phosphatase activity
RGna_RS08760	COG0698	ribose 5-phosphate isomerase
RGna_RS08770	COG1175	transmembrane transport
RGna_RS08785	COG1132	(ABC) transporter
RGna_RS08795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RGna_RS08815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RGna_RS08820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RGna_RS08825	COG0049	tRNA binding
RGna_RS08830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RGna_RS08845	COG3853	Toxic anion resistance protein (TelA)
RGna_RS08855	COG0564	pseudouridine synthase activity
RGna_RS08860	COG3263	regulation of cellular component size
RGna_RS08870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RGna_RS08875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RGna_RS08890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RGna_RS08895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RGna_RS08905	COG2205	protein histidine kinase activity
RGna_RS08910	COG0745	RESPONSE REGULATOR receiver
RGna_RS08920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RGna_RS08930	COG0222	ribosome binding
RGna_RS08940	COG0081	regulation of translation
RGna_RS08950	COG0250	Participates in transcription elongation, termination and antitermination
RGna_RS08960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RGna_RS08975	COG0493	'glutamate synthase
RGna_RS08975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RGna_RS08980	COG0375	protein maturation
RGna_RS08990	COG3620	sequence-specific DNA binding
RGna_RS09005	COG3335	DDE superfamily endonuclease
RGna_RS09015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RGna_RS09040	COG3716	PTS system mannose fructose sorbose family IID component
RGna_RS09045	COG3715	PTS system
RGna_RS09080	COG0583	DNA-binding transcription factor activity
RGna_RS09085	COG0076	glutamate decarboxylase activity
RGna_RS09090	COG0367	asparagine synthase
RGna_RS09100	COG0653	protein targeting
RGna_RS09140	COG0556	nucleotide-excision repair
RGna_RS09145	COG0745	RESPONSE REGULATOR receiver
RGna_RS09150	COG0642	Histidine kinase
RGna_RS09150	COG5002	protein histidine kinase activity
RGna_RS09165	COG1012	belongs to the aldehyde dehydrogenase family
RGna_RS09175	COG1151	hydroxylamine reductase activity
RGna_RS09275	COG4974	Belongs to the 'phage' integrase family
RGna_RS09320	COG2801	Transposase and inactivated derivatives
RGna_RS09370	COG1136	(ABC) transporter
RGna_RS09380	COG0793	Belongs to the peptidase S41A family
RGna_RS09405	COG0741	lytic transglycosylase activity
RGna_RS09405	COG0791	NLP P60 protein
RGna_RS09515	COG2135	peptidase activity
RGna_RS09525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RGna_RS09600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RGna_RS09605	COG1396	sequence-specific DNA binding
RGna_RS09625	COG0535	radical SAM domain protein
RGna_RS09640	COG1404	Belongs to the peptidase S8 family
RGna_RS09645	COG1132	(ABC) transporter
RGna_RS09685	COG3279	Response regulator of the LytR AlgR family
RGna_RS09735	COG4509	Sortase family
RGna_RS09750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RGna_RS09775	COG0582	viral genome integration into host DNA
RGna_RS09780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RGna_RS09780	COG0519	Catalyzes the synthesis of GMP from XMP
RGna_RS09790	COG1595	DNA-templated transcription, initiation
RGna_RS09800	COG3279	Response regulator of the LytR AlgR family
RGna_RS09805	COG2972	Histidine kinase
RGna_RS09810	COG1609	Transcriptional regulator
RGna_RS09835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RGna_RS09850	COG0544	peptidyl-prolyl cis-trans isomerase activity
RGna_RS09855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RGna_RS09870	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RGna_RS09890	COG2996	Protein conserved in bacteria
RGna_RS09910	COG1802	Transcriptional regulator
RGna_RS09915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RGna_RS09935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RGna_RS09940	COG1181	Belongs to the D-alanine--D-alanine ligase family
RGna_RS09945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RGna_RS09950	COG0561	phosphatase activity
RGna_RS09955	COG2431	L-lysine efflux transmembrane transporter activity
RGna_RS09980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RGna_RS10005	COG1131	(ABC) transporter
RGna_RS10015	COG2205	protein histidine kinase activity
RGna_RS10030	COG0745	RESPONSE REGULATOR receiver
RGna_RS10035	COG0159	tryptophan synthase activity
RGna_RS10040	COG0133	tryptophan synthase activity
RGna_RS10060	COG0512	Glutamine amidotransferase of anthranilate synthase
RGna_RS10120	COG3481	metal-dependent phosphohydrolase, HD sub domain
RGna_RS10125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGna_RS10130	COG1193	negative regulation of DNA recombination
RGna_RS10135	COG0745	RESPONSE REGULATOR receiver
RGna_RS10140	COG5002	protein histidine kinase activity
RGna_RS10155	COG0701	Predicted permease
RGna_RS10180	COG0789	Transcriptional regulator
RGna_RS10185	COG0305	Participates in initiation and elongation during chromosome replication
RGna_RS10190	COG0359	binds to the 23S rRNA
RGna_RS10195	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
RGna_RS10200	COG0628	permease
RGna_RS10205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RGna_RS10210	COG0629	single-stranded DNA binding
RGna_RS10215	COG0360	Binds together with S18 to 16S ribosomal RNA
RGna_RS10225	COG4509	Sortase family
RGna_RS10235	COG0561	phosphatase activity
RGna_RS10275	COG0395	ABC-type sugar transport system, permease component
RGna_RS10280	COG1175	transmembrane transport
RGna_RS10290	COG2972	Histidine kinase
RGna_RS10295	COG4753	response regulator
RGna_RS10295	COG2207	Transcriptional regulator
RGna_RS10310	COG1501	Belongs to the glycosyl hydrolase 31 family
RGna_RS10330	COG1705	Flagellar rod assembly protein muramidase FlgJ
RGna_RS10335	COG4824	toxin secretion phage lysis holin
RGna_RS10390	COG3209	COG3209 Rhs family protein
RGna_RS10395	COG1396	sequence-specific DNA binding
RGna_RS10445	COG3958	Transketolase
RGna_RS10450	COG3959	Transketolase, thiamine diphosphate binding domain
RGna_RS10465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RGna_RS10470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RGna_RS10475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RGna_RS10480	COG0205	6-phosphofructokinase activity
RGna_RS10500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGna_RS10510	COG0037	tRNA processing
RGna_RS10535	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RGna_RS10540	COG0776	regulation of translation
RGna_RS10545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RGna_RS10555	COG0617	tRNA 3'-terminal CCA addition
RGna_RS10565	COG0420	3'-5' exonuclease activity
RGna_RS10595	COG0583	DNA-binding transcription factor activity
RGna_RS10605	COG3142	Participates in the control of copper homeostasis
RGna_RS10610	COG1263	PTS System
RGna_RS10610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS10615	COG1263	PTS System
RGna_RS10615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS10615	COG2190	(PTS) system
RGna_RS10620	COG3711	transcriptional antiterminator
RGna_RS10625	COG0363	glucosamine-6-phosphate deaminase activity
RGna_RS10630	COG0101	tRNA pseudouridine synthase activity
RGna_RS10635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RGna_RS10640	COG1122	ATPase activity
RGna_RS10645	COG1122	ATPase activity
RGna_RS10655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RGna_RS10670	COG3842	ATPase activity
RGna_RS10675	COG2508	Transcriptional regulator
RGna_RS10690	COG1609	Transcriptional regulator
RGna_RS10720	COG2205	protein histidine kinase activity
RGna_RS10735	COG1136	(ABC) transporter
RGna_RS10740	COG1132	(ABC) transporter
RGna_RS10745	COG1132	(ABC) transporter
RGna_RS10760	COG3842	ATPase activity
RGna_RS10765	COG4120	Belongs to the binding-protein-dependent transport system permease family
RGna_RS10785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGna_RS10790	COG1979	alcohol dehydrogenase
RGna_RS10795	COG0546	phosphoglycolate phosphatase activity
RGna_RS10805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGna_RS10810	COG0135	phosphoribosylanthranilate isomerase activity
RGna_RS10820	COG1122	ATPase activity
RGna_RS10865	COG0305	Participates in initiation and elongation during chromosome replication
RGna_RS10885	COG2205	protein histidine kinase activity
RGna_RS10900	COG0582	viral genome integration into host DNA
RGna_RS10910	COG2946	Replication initiation factor
RGna_RS10990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RGna_RS10995	COG0084	hydrolase, TatD family'
RGna_RS11015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RGna_RS11035	COG2211	Major facilitator Superfamily
RGna_RS11045	COG0166	Belongs to the GPI family
RGna_RS11070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RGna_RS11080	COG0537	adenosine 5'-monophosphoramidase activity
RGna_RS11085	COG3852	Histidine kinase
RGna_RS11090	COG0705	Rhomboid family
RGna_RS11090	COG0457	Tetratricopeptide repeat
RGna_RS11160	COG0009	L-threonylcarbamoyladenylate synthase
RGna_RS11165	COG0860	N-Acetylmuramoyl-L-alanine amidase
RGna_RS11170	COG0446	pyridine nucleotide-disulphide oxidoreductase
RGna_RS11170	COG1902	pentaerythritol trinitrate reductase activity
RGna_RS11180	COG2207	Transcriptional regulator
RGna_RS11185	COG2211	Major facilitator Superfamily
RGna_RS11195	COG3858	chitin binding
RGna_RS11205	COG4862	establishment of competence for transformation
RGna_RS11215	COG0791	NLP P60 protein
RGna_RS11220	COG0735	belongs to the Fur family
RGna_RS11225	COG1592	Rubrerythrin
RGna_RS11225	COG1773	rubredoxin
RGna_RS11235	COG0739	heme binding
RGna_RS11240	COG2385	sporulation resulting in formation of a cellular spore
RGna_RS11250	COG0058	SHG alpha-glucan phosphorylase activity
RGna_RS11255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RGna_RS11290	COG0484	heat shock protein binding
RGna_RS11295	COG0071	Belongs to the small heat shock protein (HSP20) family
RGna_RS11315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RGna_RS11320	COG1053	succinate dehydrogenase
RGna_RS11335	COG2217	Heavy metal translocating P-type atpase
RGna_RS11390	COG1971	Probably functions as a manganese efflux pump
RGna_RS11395	COG1918	ferrous iron import across plasma membrane
RGna_RS11395	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RGna_RS11400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RGna_RS11425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RGna_RS11445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RGna_RS11455	COG1475	DNA binding
RGna_RS11460	COG1192	Involved in chromosome partitioning
RGna_RS11470	COG0357	Ribosomal RNA small subunit methyltransferase G
RGna_RS11475	COG0445	tRNA wobble uridine modification
RGna_RS11480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RGna_RS11485	COG1847	R3H domain protein
RGna_RS11490	COG0706	membrane insertase activity
RGna_RS11495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RGna_RS11500	COG0594	ribonuclease P activity
RGna_RS11505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RGna_RS11510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RGna_RS11515	COG0592	DNA-directed DNA polymerase activity
RGna_RS11530	COG0187	DNA topoisomerase II activity
RGna_RS11535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RGna_RS11545	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RGna_RS11560	COG0583	DNA-binding transcription factor activity
RGna_RS11565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RGna_RS11570	COG2011	ABC-type metal ion transport system permease component
RGna_RS11575	COG1464	Belongs to the NlpA lipoprotein family
RGna_RS11645	COG1982	Orn Lys Arg decarboxylase major
RGna_RS11650	COG0194	GDP metabolic process
RGna_RS11660	COG1175	transmembrane transport
RGna_RS11680	COG0546	phosphoglycolate phosphatase activity
RGna_RS11685	COG3842	ATPase activity
RGna_RS11690	COG0470	DNA polymerase III
RGna_RS11695	COG1774	PSP1 C-terminal conserved region
RGna_RS11700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RGna_RS11705	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RGna_RS11710	COG3842	ATPase activity
RGna_RS11725	COG2715	membrane protein required for spore maturation
RGna_RS11740	COG3279	Response regulator of the LytR AlgR family
RGna_RS11750	COG3250	beta-galactosidase activity
RGna_RS11780	COG0622	Phosphoesterase
RGna_RS11800	COG1725	Transcriptional regulator
RGna_RS11805	COG1131	(ABC) transporter
RGna_RS11815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RGna_RS11825	COG0157	Belongs to the NadC ModD family
RGna_RS11830	COG1827	regulation of RNA biosynthetic process
RGna_RS11835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGna_RS11835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGna_RS11845	COG4786	Flagellar basal body rod
RGna_RS11865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RGna_RS11870	COG0297	glycogen (starch) synthase activity
RGna_RS11875	COG0463	Glycosyl transferase, family 2
RGna_RS11885	COG0726	polysaccharide deacetylase
RGna_RS11885	COG1649	PFAM Uncharacterised BCR, COG1649
RGna_RS11890	COG0438	transferase activity, transferring glycosyl groups
RGna_RS11900	COG0438	transferase activity, transferring glycosyl groups
RGna_RS11920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RGna_RS11940	COG2089	acid synthase
RGna_RS11970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RGna_RS11990	COG4509	Sortase family
RGna_RS12010	COG4464	protein tyrosine phosphatase activity
RGna_RS12035	COG3250	beta-galactosidase activity
RGna_RS12050	COG1472	Belongs to the glycosyl hydrolase 3 family
RGna_RS12080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RGna_RS12085	COG1473	amidohydrolase
RGna_RS12095	COG3022	response to hydroperoxide
RGna_RS12105	COG0424	maF-like protein
RGna_RS12130	COG0356	it plays a direct role in the translocation of protons across the membrane
RGna_RS12135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RGna_RS12140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RGna_RS12145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RGna_RS12150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RGna_RS12155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RGna_RS12160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RGna_RS12180	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RGna_RS12195	COG0446	pyridine nucleotide-disulphide oxidoreductase
RGna_RS12205	COG1151	hydroxylamine reductase activity
RGna_RS12215	COG1609	Transcriptional regulator
RGna_RS12220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGna_RS12235	COG1172	Belongs to the binding-protein-dependent transport system permease family
RGna_RS12240	COG1879	ABC-type sugar transport system periplasmic component
RGna_RS12260	COG1132	(ABC) transporter
RGna_RS12285	COG0514	ATP-dependent DNA helicase (RecQ)
RGna_RS12295	COG2832	Protein of unknown function (DUF454)
RGna_RS12305	COG4988	ABC transporter
RGna_RS12310	COG1132	(ABC) transporter
RGna_RS12325	COG1695	Transcriptional regulator
RGna_RS12340	COG1982	Orn Lys Arg decarboxylase major
RGna_RS12345	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RGna_RS12350	COG0010	Belongs to the arginase family
RGna_RS12365	COG0493	'glutamate synthase
RGna_RS12375	COG1012	belongs to the aldehyde dehydrogenase family
RGna_RS12400	COG2176	DNA-directed DNA polymerase activity
RGna_RS12435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RGna_RS12440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RGna_RS12445	COG0586	Pfam SNARE associated Golgi protein
RGna_RS12450	COG0438	transferase activity, transferring glycosyl groups
RGna_RS12465	COG5002	protein histidine kinase activity
RGna_RS12485	COG1917	Cupin 2, conserved barrel domain protein
RGna_RS12485	COG2207	Transcriptional regulator
RGna_RS12495	COG1132	(ABC) transporter
RGna_RS12510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RGna_RS12520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RGna_RS12525	COG1254	Belongs to the acylphosphatase family
RGna_RS12530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RGna_RS12535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RGna_RS12560	COG2972	Histidine kinase
RGna_RS12570	COG1328	CTP reductase activity
RGna_RS12570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RGna_RS12575	COG0492	ferredoxin-NADP+ reductase activity
RGna_RS12590	COG1876	peptidase activity
RGna_RS12600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RGna_RS12610	COG0590	tRNA wobble adenosine to inosine editing
RGna_RS12625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RGna_RS12635	COG1522	sequence-specific DNA binding
RGna_RS12640	COG0436	Aminotransferase
RGna_RS12650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGna_RS12660	COG1269	ATP hydrolysis coupled proton transport
RGna_RS12665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RGna_RS12730	COG1120	ATPase activity
RGna_RS12740	COG0673	inositol 2-dehydrogenase activity
RGna_RS12745	COG2207	Transcriptional regulator
RGna_RS12760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RGna_RS12765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RGna_RS12775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RGna_RS12780	COG5002	protein histidine kinase activity
RGna_RS12785	COG0745	RESPONSE REGULATOR receiver
RGna_RS12790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RGna_RS12795	COG0569	domain protein
RGna_RS12800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGna_RS12805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RGna_RS12810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RGna_RS12810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RGna_RS12820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RGna_RS12825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RGna_RS12830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RGna_RS12845	COG1192	Involved in chromosome partitioning
RGna_RS12860	COG3715	PTS system
RGna_RS12865	COG3716	PTS system mannose fructose sorbose family IID component
RGna_RS12870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RGna_RS12875	COG0371	Dehydrogenase
RGna_RS12890	COG0655	NAD(P)H dehydrogenase (quinone) activity
RGna_RS12920	COG2508	Transcriptional regulator
RGna_RS12920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
RGna_RS12925	COG0681	Belongs to the peptidase S26 family
RGna_RS12935	COG4509	Sortase family
RGna_RS12960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RGna_RS12990	COG0582	viral genome integration into host DNA
RGna_RS13075	COG0205	6-phosphofructokinase activity
RGna_RS13080	COG1215	transferase activity, transferring glycosyl groups
RGna_RS13085	COG1592	Rubrerythrin
RGna_RS13090	COG1404	Belongs to the peptidase S8 family
RGna_RS13125	COG1394	ATPase activity, coupled to movement of substances
RGna_RS13155	COG1269	ATP hydrolysis coupled proton transport
RGna_RS13175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RGna_RS13180	COG3118	belongs to the thioredoxin family
RGna_RS13190	COG2207	Transcriptional regulator
RGna_RS13190	COG4753	response regulator
RGna_RS13205	COG1609	Transcriptional regulator
RGna_RS13215	COG3959	Transketolase, thiamine diphosphate binding domain
RGna_RS13220	COG3958	Transketolase
RGna_RS13225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RGna_RS13235	COG0534	Mate efflux family protein
RGna_RS13395	COG0629	single-stranded DNA binding
RGna_RS13475	COG2270	Major facilitator Superfamily
RGna_RS13480	COG1362	aminopeptidase activity
RGna_RS13485	COG0745	RESPONSE REGULATOR receiver
RGna_RS13500	COG1051	belongs to the nudix hydrolase family
RGna_RS13510	COG0513	Belongs to the DEAD box helicase family
RGna_RS13540	COG0517	IMP dehydrogenase activity
RGna_RS13560	COG0549	Belongs to the carbamate kinase family
RGna_RS13575	COG1132	(ABC) transporter
RGna_RS13585	COG4555	ABC transporter
RGna_RS13590	COG1668	transmembrane transport
RGna_RS13610	COG0708	Exodeoxyribonuclease III
RGna_RS13615	COG0523	cobalamin synthesis protein
RGna_RS13645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RGna_RS13660	COG1192	Involved in chromosome partitioning
RGna_RS13665	COG1475	DNA binding
RGna_RS13685	COG3617	BRO family, N-terminal domain
RGna_RS13775	COG0358	DNA primase activity
RGna_RS13855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RGna_RS13855	COG0551	DNA topoisomerase type I activity
RGna_RS13865	COG0358	DNA primase activity
RGna_RS13945	COG1396	sequence-specific DNA binding
RGna_RS13950	COG0745	RESPONSE REGULATOR receiver
RGna_RS13955	COG5002	protein histidine kinase activity
RGna_RS13975	COG1136	(ABC) transporter
RGna_RS14005	COG0745	RESPONSE REGULATOR receiver
RGna_RS14010	COG2205	protein histidine kinase activity
RGna_RS14015	COG1136	(ABC) transporter
RGna_RS14060	COG4804	nuclease activity
RGna_RS14080	COG0583	DNA-binding transcription factor activity
RGna_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
RGna_RS14120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RGna_RS14130	COG0252	asparaginase activity
RGna_RS14150	COG1253	flavin adenine dinucleotide binding
RGna_RS14160	COG0138	bifunctional purine biosynthesis protein purh
RGna_RS14165	COG0802	atpase or kinase
RGna_RS14170	COG1214	PFAM Peptidase M22, glycoprotease
RGna_RS14180	COG1234	tRNA 3'-trailer cleavage
RGna_RS14190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RGna_RS14295	COG0564	pseudouridine synthase activity
RGna_RS14300	COG2183	response to ionizing radiation
RGna_RS14305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RGna_RS14310	COG4684	Psort location CytoplasmicMembrane, score
RGna_RS14315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RGna_RS14320	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
RGna_RS14325	COG0534	Mate efflux family protein
RGna_RS14345	COG3409	Peptidoglycan-binding domain 1 protein
RGna_RS14345	COG3773	Cell wall hydrolase
RGna_RS14350	COG0551	DNA topoisomerase type I activity
RGna_RS14350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RGna_RS14360	COG0148	phosphopyruvate hydratase activity
RGna_RS14380	COG3711	transcriptional antiterminator
RGna_RS14385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS14385	COG2190	(PTS) system
RGna_RS14385	COG1263	PTS System
RGna_RS14390	COG2723	6-phospho-beta-galactosidase activity
RGna_RS14400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RGna_RS14405	COG0557	exoribonuclease II activity
RGna_RS14410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RGna_RS14440	COG1070	Carbohydrate kinase
RGna_RS14445	COG1874	Beta-galactosidase
RGna_RS14450	COG1621	beta-fructofuranosidase activity
RGna_RS14470	COG0561	phosphatase activity
RGna_RS14510	COG0582	viral genome integration into host DNA
RGna_RS14515	COG0517	IMP dehydrogenase activity
RGna_RS14525	COG1732	Glycine betaine
RGna_RS14560	COG0745	RESPONSE REGULATOR receiver
RGna_RS14565	COG5002	protein histidine kinase activity
RGna_RS14570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RGna_RS14575	COG0107	imidazoleglycerol-phosphate synthase activity
RGna_RS14590	COG1136	(ABC) transporter
RGna_RS14600	COG0577	efflux transmembrane transporter activity
RGna_RS14615	COG2197	response regulator
RGna_RS14620	COG4585	Histidine kinase
RGna_RS14625	COG1131	(ABC) transporter
RGna_RS14640	COG0367	asparagine synthase
RGna_RS14645	COG0070	glutamate synthase
RGna_RS14645	COG0069	glutamate synthase activity
RGna_RS14645	COG0067	glutamate synthase
RGna_RS14650	COG0493	'glutamate synthase
RGna_RS14665	COG0436	Aminotransferase
RGna_RS14670	COG2357	RelA SpoT domain protein
RGna_RS14680	COG1917	Cupin 2, conserved barrel domain protein
RGna_RS14680	COG2207	Transcriptional regulator
RGna_RS14690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RGna_RS14695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS14700	COG3715	PTS system
RGna_RS14705	COG3716	PTS system mannose fructose sorbose family IID component
RGna_RS14715	COG1609	Transcriptional regulator
RGna_RS14730	COG2207	Transcriptional regulator
RGna_RS14735	COG3250	beta-galactosidase activity
RGna_RS14750	COG5002	protein histidine kinase activity
RGna_RS14755	COG2217	Heavy metal translocating P-type atpase
RGna_RS14760	COG0640	Transcriptional regulator
RGna_RS14765	COG2217	Heavy metal translocating P-type atpase
RGna_RS14775	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RGna_RS14780	COG0785	Cytochrome C biogenesis protein
RGna_RS14785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RGna_RS14790	COG1733	regulation of RNA biosynthetic process
RGna_RS14800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RGna_RS14810	COG1028	Short-chain dehydrogenase reductase Sdr
RGna_RS14835	COG3620	sequence-specific DNA binding
RGna_RS14850	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
RGna_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
RGna_RS14870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RGna_RS14880	COG1609	Transcriptional regulator
RGna_RS14880	COG2207	Transcriptional regulator
RGna_RS14885	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RGna_RS14890	COG1070	Carbohydrate kinase
RGna_RS14895	COG4806	L-rhamnose isomerase
RGna_RS14900	COG2207	Transcriptional regulator
RGna_RS14900	COG1917	Cupin 2, conserved barrel domain protein
RGna_RS14905	COG1501	Belongs to the glycosyl hydrolase 31 family
RGna_RS14910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RGna_RS14915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RGna_RS14935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RGna_RS14945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RGna_RS14965	COG1063	alcohol dehydrogenase
RGna_RS14975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RGna_RS14985	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RGna_RS14990	COG4869	propanediol catabolic process
RGna_RS14995	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
RGna_RS15000	COG4656	Part of a membrane complex involved in electron transport
RGna_RS15010	COG1349	DNA-binding transcription factor activity
RGna_RS15025	COG1609	Transcriptional regulator
RGna_RS15025	COG2207	Transcriptional regulator
RGna_RS15030	COG1129	ABC transporter
RGna_RS15035	COG1172	Belongs to the binding-protein-dependent transport system permease family
RGna_RS15040	COG1172	Belongs to the binding-protein-dependent transport system permease family
RGna_RS15050	COG1070	Carbohydrate kinase
RGna_RS15055	COG3254	rhamnose metabolic process
RGna_RS15060	COG1609	Transcriptional regulator
RGna_RS15060	COG2207	Transcriptional regulator
RGna_RS15065	COG1312	Catalyzes the dehydration of D-mannonate
RGna_RS15075	COG1904	glucuronate isomerase
RGna_RS15080	COG1414	Transcriptional regulator
RGna_RS15085	COG0800	Aldolase
RGna_RS15100	COG1609	Transcriptional regulator
RGna_RS15105	COG1070	Carbohydrate kinase
RGna_RS15110	COG1063	alcohol dehydrogenase
RGna_RS15115	COG1105	Belongs to the carbohydrate kinase PfkB family
RGna_RS15120	COG0656	L-ascorbic acid biosynthetic process
RGna_RS15135	COG2190	(PTS) system
RGna_RS15135	COG1263	PTS System
RGna_RS15135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RGna_RS15145	COG2972	Histidine kinase
RGna_RS15155	COG4214	carbohydrate transport
RGna_RS15160	COG1129	ABC transporter
RGna_RS15165	COG4211	Belongs to the binding-protein-dependent transport system permease family
RGna_RS15185	COG1070	Carbohydrate kinase
RGna_RS15190	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
RGna_RS15195	COG4154	Belongs to the RbsD FucU family
RGna_RS15215	COG0285	dihydrofolate synthase activity
RGna_RS15225	COG1366	Belongs to the anti-sigma-factor antagonist family
RGna_RS15285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RGna_RS15290	COG0573	inorganic phosphate transmembrane transporter activity
RGna_RS15295	COG0581	inorganic phosphate transmembrane transporter activity
RGna_RS15310	COG0745	RESPONSE REGULATOR receiver
RGna_RS15315	COG5002	protein histidine kinase activity
RGna_RS15325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RGna_RS15330	COG1725	Transcriptional regulator
RGna_RS15335	COG0542	response to heat
RGna_RS15345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RGna_RS15400	COG2080	2 iron, 2 sulfur cluster binding
RGna_RS15400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RGna_RS15440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RGna_RS15455	COG1846	Transcriptional regulator
RGna_RS15465	COG1132	(ABC) transporter
RGna_RS15475	COG0521	Mo-molybdopterin cofactor biosynthetic process
RGna_RS15495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RGna_RS15500	COG1104	cysteine desulfurase activity
RGna_RS15505	COG0301	tRNA thio-modification
RGna_RS15515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RGna_RS15520	COG4472	Bacterial protein of unknown function (DUF965)
RGna_RS15535	COG0735	belongs to the Fur family
RGna_RS15540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RGna_RS15555	COG1191	sigma factor activity
RGna_RS15565	COG0758	DNA mediated transformation
RGna_RS15570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RGna_RS15655	COG0455	bacterial-type flagellum organization
RGna_RS15680	COG0629	single-stranded DNA binding
RGna_RS15705	COG4626	Terminase
RGna_RS15705	COG1802	Transcriptional regulator
RGna_RS15850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RGna_RS15855	COG0459	protein refolding
RGna_RS15860	COG0516	GMP reductase activity
RGna_RS15860	COG0517	IMP dehydrogenase activity
RGna_RS15870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RGna_RS15875	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RGna_RS15900	COG1131	(ABC) transporter
RGna_RS15905	COG1725	Transcriptional regulator
RGna_RS15910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RGna_RS15920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RGna_RS15925	COG1266	CAAX protease self-immunity
RGna_RS15955	COG1388	LysM domain
RGna_RS15955	COG0791	NLP P60 protein
RGna_RS15965	COG0052	Belongs to the universal ribosomal protein uS2 family
RGna_RS15970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RGna_RS15985	COG1028	Short-chain dehydrogenase reductase Sdr
RGna_RS15990	COG3201	nicotinamide mononucleotide transporter
RGna_RS15995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGna_RS16000	COG1397	ADP-ribosylglycohydrolase
RGna_RS16005	COG2188	Transcriptional regulator
RGna_RS16010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RGna_RS16025	COG0572	uridine kinase
RGna_RS16030	COG0598	Magnesium transport protein CorA
RGna_RS16045	COG1609	Transcriptional regulator
RGna_RS16055	COG1621	beta-fructofuranosidase activity
RGna_RS16065	COG0549	Belongs to the carbamate kinase family
RGna_RS16070	COG0251	oxidation-reduction process
RGna_RS16075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RGna_RS16080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RGna_RS16095	COG0402	S-adenosylhomocysteine deaminase activity
RGna_RS16100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RGna_RS16100	COG0493	'glutamate synthase
RGna_RS16105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RGna_RS16110	COG3608	succinylglutamate desuccinylase aspartoacylase
RGna_RS16110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RGna_RS16120	COG0725	ABC transporter, periplasmic molybdate-binding protein
RGna_RS16125	COG4149	molybdate abc transporter
RGna_RS16150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGna_RS16170	COG3620	sequence-specific DNA binding
RGna_RS16240	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
RGna_RS16430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGna_RS16445	COG4496	protein, YerC YecD
RGna_RS16460	COG0210	DNA helicase
RGna_RS16490	COG1132	(ABC) transporter
RGna_RS16515	COG1131	(ABC) transporter
RGna_RS16615	COG1131	(ABC) transporter
RGna_RS16680	COG1518	maintenance of DNA repeat elements
RGna_RS16685	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RGna_RS16695	COG3300	MHYT domain
RGna_RS16695	COG5001	Diguanylate cyclase
RGna_RS16705	COG5002	protein histidine kinase activity
RGna_RS16705	COG5000	phosphorelay sensor kinase activity
RGna_RS16710	COG1136	(ABC) transporter
RGna_RS16740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RGna_RS16750	COG3901	Regulator of nitric oxide reductase transcription
RGna_RS16750	COG0348	domain, Protein
RGna_RS16770	COG2239	Acts as a magnesium transporter
RGna_RS16775	COG2226	methyltransferase
RGna_RS16780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RGna_RS16785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RGna_RS16785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RGna_RS16795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RGna_RS16795	COG3608	succinylglutamate desuccinylase aspartoacylase
RGna_RS16800	COG0402	S-adenosylhomocysteine deaminase activity
RGna_RS16805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RGna_RS16810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RGna_RS16815	COG2080	2 iron, 2 sulfur cluster binding
RGna_RS16830	COG0735	belongs to the Fur family
RGna_RS16875	COG4443	Transcriptional Coactivator p15 (PC4)
RGna_RS16880	COG1475	DNA binding
RGna_RS16950	COG0534	Mate efflux family protein
RGna_RS16980	COG0745	RESPONSE REGULATOR receiver
RGna_RS16995	COG0726	polysaccharide deacetylase
RGna_RS17010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RGna_RS17015	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RGna_RS17020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RGna_RS17025	COG0038	chloride channel
RGna_RS17035	COG0233	cytoplasmic translational termination
RGna_RS17045	COG4589	Belongs to the CDS family
RGna_RS17055	COG0750	zinc metalloprotease
RGna_RS17060	COG5632	N-Acetylmuramoyl-L-alanine amidase
RGna_RS17060	COG3409	Peptidoglycan-binding domain 1 protein
RGna_RS17070	COG1346	cytolysis
RGna_RS17080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGna_RS17100	COG1653	transport
RGna_RS17105	COG1175	transmembrane transport
RGna_RS17115	COG0395	ABC-type sugar transport system, permease component
RGna_RS17130	COG2207	Transcriptional regulator
RGna_RS17135	COG1134	teichoic acid transport
RGna_RS17150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RGna_RS17155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RGna_RS17165	COG0709	Synthesizes selenophosphate from selenide and ATP
RGna_RS17175	COG1104	cysteine desulfurase activity
RGna_RS17190	COG1739	Uncharacterized protein family UPF0029
RGna_RS17195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RGna_RS17215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGna_RS17220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RGna_RS17225	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
RGna_RS17230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RGna_RS17245	COG0653	protein targeting
RGna_RS17255	COG0460	homoserine dehydrogenase
RGna_RS17260	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
RGna_RS17285	COG0544	peptidyl-prolyl cis-trans isomerase activity
RGna_RS17295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RGna_RS17300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RGna_RS17305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RGna_RS17315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RGna_RS17325	COG0745	RESPONSE REGULATOR receiver
RGna_RS17330	COG5002	protein histidine kinase activity
RGna_RS17335	COG1136	(ABC) transporter
RGna_RS17335	COG0577	efflux transmembrane transporter activity
RGna_RS17365	COG1131	(ABC) transporter
RGna_RS17380	COG0745	RESPONSE REGULATOR receiver
RGna_RS17385	COG5002	protein histidine kinase activity
RGna_RS17385	COG0642	Histidine kinase
RGna_RS17390	COG1979	alcohol dehydrogenase
RGna_RS17395	COG0426	domain, Protein
RGna_RS17400	COG1151	hydroxylamine reductase activity
RGna_RS17410	COG4804	nuclease activity
RGna_RS17430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RGna_RS17435	COG1040	competence protein
RGna_RS17475	COG0463	Glycosyl transferase, family 2
RGna_RS17515	COG0438	transferase activity, transferring glycosyl groups
RGna_RS17515	COG1216	Glycosyl transferase, family 2
RGna_RS17540	COG0438	transferase activity, transferring glycosyl groups
RGna_RS17545	COG1216	Glycosyl transferase, family 2
RGna_RS17570	COG1316	TRANSCRIPTIONal
RGna_RS17580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RGna_RS17585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGna_RS17615	COG0745	RESPONSE REGULATOR receiver
RGna_RS17630	COG2205	protein histidine kinase activity
RGna_RS17655	COG0791	NLP P60 protein
RGna_RS17655	COG0741	lytic transglycosylase activity