locus-tag	class	description
E5Z56_RS00020	COG1758	RNA polymerase activity
E5Z56_RS00030	COG2052	Domain of unknown function (DUF370)
E5Z56_RS00050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Z56_RS00085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5Z56_RS00105	COG0484	heat shock protein binding
E5Z56_RS00115	COG0004	ammonium transporteR
E5Z56_RS00125	COG0347	Belongs to the P(II) protein family
E5Z56_RS00155	COG1959	2 iron, 2 sulfur cluster binding
E5Z56_RS00160	COG0626	cystathionine gamma-synthase activity
E5Z56_RS00175	COG1408	metallophosphoesterase
E5Z56_RS00180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5Z56_RS00205	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
E5Z56_RS00210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E5Z56_RS00220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5Z56_RS00230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5Z56_RS00265	COG1523	belongs to the glycosyl hydrolase 13 family
E5Z56_RS00270	COG1523	belongs to the glycosyl hydrolase 13 family
E5Z56_RS00275	COG0148	phosphopyruvate hydratase activity
E5Z56_RS00280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5Z56_RS00285	COG0358	DNA primase activity
E5Z56_RS00290	COG1739	Uncharacterized protein family UPF0029
E5Z56_RS00295	COG0254	rRNA binding
E5Z56_RS00305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5Z56_RS00315	COG1686	Belongs to the peptidase S11 family
E5Z56_RS00325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5Z56_RS00330	COG1461	Dihydroxyacetone kinase
E5Z56_RS00335	COG2359	stage V sporulation protein S
E5Z56_RS00340	COG1692	metallophosphoesterase
E5Z56_RS00360	COG0367	asparagine synthase
E5Z56_RS00375	COG1349	DNA-binding transcription factor activity
E5Z56_RS00380	COG1105	Belongs to the carbohydrate kinase PfkB family
E5Z56_RS00385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Z56_RS00385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5Z56_RS00385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5Z56_RS00395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5Z56_RS00425	COG4509	Sortase family
E5Z56_RS00435	COG0131	Imidazoleglycerol-phosphate dehydratase
E5Z56_RS00440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5Z56_RS00445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5Z56_RS00460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5Z56_RS00465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5Z56_RS00470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5Z56_RS00475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5Z56_RS00480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5Z56_RS00485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5Z56_RS00490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5Z56_RS00510	COG0356	it plays a direct role in the translocation of protons across the membrane
E5Z56_RS00515	COG0667	Aldo Keto reductase
E5Z56_RS00520	COG0668	transmembrane transport
E5Z56_RS00540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E5Z56_RS00550	COG2252	PERMEase
E5Z56_RS00560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5Z56_RS00565	COG0251	oxidation-reduction process
E5Z56_RS00595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5Z56_RS00610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5Z56_RS00615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5Z56_RS00615	COG0574	Belongs to the PEP-utilizing enzyme family
E5Z56_RS00645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5Z56_RS00660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5Z56_RS00680	COG1401	restriction endodeoxyribonuclease activity
E5Z56_RS00700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5Z56_RS00705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5Z56_RS00725	COG0440	acetolactate synthase activity
E5Z56_RS00730	COG0028	Belongs to the TPP enzyme family
E5Z56_RS00740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5Z56_RS00745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5Z56_RS00750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5Z56_RS00755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5Z56_RS00800	COG1396	sequence-specific DNA binding
E5Z56_RS00845	COG1475	DNA binding
E5Z56_RS00905	COG0733	neurotransmitter:sodium symporter activity
E5Z56_RS00915	COG0242	peptide deformylase activity
E5Z56_RS00925	COG0534	Mate efflux family protein
E5Z56_RS00930	COG0640	Transcriptional regulator
E5Z56_RS00935	COG2217	Heavy metal translocating P-type atpase
E5Z56_RS00940	COG0598	Magnesium transport protein CorA
E5Z56_RS00945	COG1454	alcohol dehydrogenase
E5Z56_RS00965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5Z56_RS00965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5Z56_RS00970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5Z56_RS00970	COG1328	CTP reductase activity
E5Z56_RS00985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5Z56_RS01005	COG3546	catalase activity
E5Z56_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
E5Z56_RS01010	COG1454	alcohol dehydrogenase
E5Z56_RS01015	COG1971	Probably functions as a manganese efflux pump
E5Z56_RS01020	COG0824	Thioesterase
E5Z56_RS01025	COG0318	PFAM AMP-dependent synthetase and ligase
E5Z56_RS01030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5Z56_RS01035	COG0583	DNA-binding transcription factor activity
E5Z56_RS01040	COG1122	ATPase activity
E5Z56_RS01045	COG4120	Belongs to the binding-protein-dependent transport system permease family
E5Z56_RS01060	COG0463	Glycosyl transferase, family 2
E5Z56_RS01065	COG0517	IMP dehydrogenase activity
E5Z56_RS01080	COG0366	Alpha amylase catalytic
E5Z56_RS01100	COG1733	regulation of RNA biosynthetic process
E5Z56_RS01115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5Z56_RS01170	COG0542	response to heat
E5Z56_RS01175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5Z56_RS01190	COG0101	tRNA pseudouridine synthase activity
E5Z56_RS01195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5Z56_RS01200	COG1122	ATPase activity
E5Z56_RS01205	COG1122	ATPase activity
E5Z56_RS01210	COG0116	Belongs to the methyltransferase superfamily
E5Z56_RS01210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5Z56_RS01220	COG2255	four-way junction helicase activity
E5Z56_RS01225	COG0632	four-way junction helicase activity
E5Z56_RS01230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5Z56_RS01250	COG1316	TRANSCRIPTIONal
E5Z56_RS01255	COG1316	TRANSCRIPTIONal
E5Z56_RS01260	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E5Z56_RS01270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5Z56_RS01285	COG3475	LICD family
E5Z56_RS01295	COG1063	alcohol dehydrogenase
E5Z56_RS01315	COG0366	Alpha amylase catalytic
E5Z56_RS01340	COG3118	belongs to the thioredoxin family
E5Z56_RS01350	COG2843	Capsule synthesis protein
E5Z56_RS01385	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E5Z56_RS01390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Z56_RS01445	COG1418	mRNA catabolic process
E5Z56_RS01460	COG0346	lactoylglutathione lyase activity
E5Z56_RS01465	COG1592	Rubrerythrin
E5Z56_RS01480	COG0733	neurotransmitter:sodium symporter activity
E5Z56_RS01495	COG1785	Belongs to the alkaline phosphatase family
E5Z56_RS01500	COG1136	(ABC) transporter
E5Z56_RS01505	COG2217	Heavy metal translocating P-type atpase
E5Z56_RS01515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5Z56_RS01530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5Z56_RS01545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5Z56_RS01545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5Z56_RS01565	COG1408	metallophosphoesterase
E5Z56_RS01570	COG2309	aminopeptidase activity
E5Z56_RS01575	COG0561	phosphatase activity
E5Z56_RS01580	COG1476	TRANSCRIPTIONal
E5Z56_RS01595	COG1115	amino acid carrier protein
E5Z56_RS01625	COG0529	Catalyzes the synthesis of activated sulfate
E5Z56_RS01630	COG0745	RESPONSE REGULATOR receiver
E5Z56_RS01640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5Z56_RS01650	COG1408	metallophosphoesterase
E5Z56_RS01660	COG1595	DNA-templated transcription, initiation
E5Z56_RS01670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5Z56_RS01685	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5Z56_RS01690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5Z56_RS01710	COG1216	Glycosyl transferase, family 2
E5Z56_RS01715	COG1442	glycosyl transferase family 8
E5Z56_RS01715	COG1216	Glycosyl transferase, family 2
E5Z56_RS01720	COG1216	Glycosyl transferase, family 2
E5Z56_RS01720	COG1442	glycosyl transferase family 8
E5Z56_RS01745	COG0438	transferase activity, transferring glycosyl groups
E5Z56_RS01755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5Z56_RS01775	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E5Z56_RS01780	COG3880	PFAM UvrB UvrC protein
E5Z56_RS01785	COG4463	regulation of RNA biosynthetic process
E5Z56_RS01810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5Z56_RS01815	COG1191	sigma factor activity
E5Z56_RS01850	COG0577	efflux transmembrane transporter activity
E5Z56_RS01850	COG1136	(ABC) transporter
E5Z56_RS01855	COG5002	protein histidine kinase activity
E5Z56_RS01855	COG3850	Histidine kinase
E5Z56_RS01860	COG0745	RESPONSE REGULATOR receiver
E5Z56_RS01895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Z56_RS01905	COG4472	Bacterial protein of unknown function (DUF965)
E5Z56_RS01910	COG0072	phenylalanine-tRNA ligase activity
E5Z56_RS01910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Z56_RS01930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5Z56_RS01930	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5Z56_RS01940	COG2337	Toxic component of a toxin-antitoxin (TA) module
E5Z56_RS02035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Z56_RS02055	COG4372	Transposase
E5Z56_RS02215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5Z56_RS02220	COG2226	methyltransferase
E5Z56_RS02225	COG4496	protein, YerC YecD
E5Z56_RS02230	COG1191	sigma factor activity
E5Z56_RS02245	COG0539	negative regulation of cytoplasmic translation
E5Z56_RS02290	COG1475	DNA binding
E5Z56_RS02320	COG2826	transposase and inactivated derivatives, IS30 family
E5Z56_RS02360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5Z56_RS02365	COG0732	type I restriction modification DNA specificity domain
E5Z56_RS02435	COG1012	belongs to the aldehyde dehydrogenase family
E5Z56_RS02435	COG1454	alcohol dehydrogenase
E5Z56_RS02440	COG0583	DNA-binding transcription factor activity
E5Z56_RS02445	COG0488	(ABC) transporter
E5Z56_RS02480	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z56_RS02490	COG3475	LICD family
E5Z56_RS02515	COG0366	Alpha amylase catalytic
E5Z56_RS02535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5Z56_RS02540	COG4224	UPF0291 protein
E5Z56_RS02545	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5Z56_RS02550	COG0704	Plays a role in the regulation of phosphate uptake
E5Z56_RS02560	COG0581	inorganic phosphate transmembrane transporter activity
E5Z56_RS02565	COG0573	inorganic phosphate transmembrane transporter activity
E5Z56_RS02575	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5Z56_RS02580	COG1489	DNA binding
E5Z56_RS02595	COG2826	transposase and inactivated derivatives, IS30 family
E5Z56_RS02635	COG1696	Membrane protein involved in D-alanine export
E5Z56_RS02640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5Z56_RS02645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5Z56_RS02705	COG0822	iron-sulfur transferase activity
E5Z56_RS02715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5Z56_RS02720	COG1959	2 iron, 2 sulfur cluster binding
E5Z56_RS02770	COG1131	(ABC) transporter
E5Z56_RS02780	COG1126	abc transporter atp-binding protein
E5Z56_RS02785	COG0765	amino acid transport
E5Z56_RS02790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5Z56_RS02795	COG1272	protein, Hemolysin III
E5Z56_RS02800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5Z56_RS02810	COG1132	(ABC) transporter
E5Z56_RS02820	COG0426	domain, Protein
E5Z56_RS02840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5Z56_RS02845	COG1882	Formate acetyltransferase
E5Z56_RS02865	COG3299	homolog of phage Mu protein gp47
E5Z56_RS02940	COG0697	spore germination
E5Z56_RS02960	COG0700	Nucleoside recognition
E5Z56_RS02965	COG2715	membrane protein required for spore maturation
E5Z56_RS02985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Z56_RS02990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5Z56_RS02995	COG1671	Belongs to the UPF0178 family
E5Z56_RS03000	COG1982	Orn Lys Arg decarboxylase major
E5Z56_RS03010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5Z56_RS03025	COG2186	Transcriptional regulator
E5Z56_RS03050	COG0523	cobalamin synthesis protein
E5Z56_RS03070	COG2827	Endonuclease containing a URI domain
E5Z56_RS03080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5Z56_RS03095	COG2323	membrane
E5Z56_RS03100	COG0167	dihydroorotate dehydrogenase activity
E5Z56_RS03105	COG0543	2 iron, 2 sulfur cluster binding
E5Z56_RS03170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5Z56_RS03210	COG2207	Transcriptional regulator
E5Z56_RS03240	COG2017	converts alpha-aldose to the beta-anomer
E5Z56_RS03245	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E5Z56_RS03250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Z56_RS03255	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5Z56_RS03260	COG2211	Major facilitator Superfamily
E5Z56_RS03265	COG1609	Transcriptional regulator
E5Z56_RS03320	COG2826	transposase and inactivated derivatives, IS30 family
E5Z56_RS03325	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E5Z56_RS03330	COG1518	maintenance of DNA repeat elements
E5Z56_RS03390	COG2002	toxin-antitoxin pair type II binding
E5Z56_RS03395	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5Z56_RS03400	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E5Z56_RS03405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5Z56_RS03420	COG0606	chelatase, subunit chli
E5Z56_RS03440	COG2384	SAM-dependent methyltransferase
E5Z56_RS03450	COG0726	polysaccharide deacetylase
E5Z56_RS03455	COG0215	cysteine-tRNA ligase activity
E5Z56_RS03460	COG1045	serine acetyltransferase
E5Z56_RS03470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5Z56_RS03475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5Z56_RS03480	COG2137	regulation of response to DNA damage stimulus
E5Z56_RS03485	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5Z56_RS03490	COG2890	protein-(glutamine-N5) methyltransferase activity
E5Z56_RS03495	COG3872	metal-dependent enzyme
E5Z56_RS03500	COG5002	protein histidine kinase activity
E5Z56_RS03515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5Z56_RS03535	COG1854	S-ribosylhomocysteine lyase activity
E5Z56_RS03540	COG0741	lytic transglycosylase activity
E5Z56_RS03540	COG1196	nuclear chromosome segregation
E5Z56_RS03540	COG0739	heme binding
E5Z56_RS03550	COG1175	transmembrane transport
E5Z56_RS03580	COG0126	phosphoglycerate kinase activity
E5Z56_RS03585	COG0149	triose-phosphate isomerase activity
E5Z56_RS03590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5Z56_RS03605	COG0129	dihydroxy-acid dehydratase activity
E5Z56_RS03615	COG0110	maltose O-acetyltransferase activity
E5Z56_RS03620	COG4106	trans-aconitate 2-methyltransferase activity
E5Z56_RS03630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5Z56_RS03630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5Z56_RS03635	COG0519	Catalyzes the synthesis of GMP from XMP
E5Z56_RS03640	COG1959	2 iron, 2 sulfur cluster binding
E5Z56_RS03650	COG1811	Na channel or pump
E5Z56_RS03710	COG4372	Transposase
E5Z56_RS03730	COG2177	Part of the ABC transporter FtsEX involved in
E5Z56_RS03735	COG2884	Cell division ATP-binding protein ftsE
E5Z56_RS03740	COG2508	Transcriptional regulator
E5Z56_RS03745	COG3842	ATPase activity
E5Z56_RS03750	COG1187	pseudouridine synthase activity
E5Z56_RS03770	COG0012	GTP binding
E5Z56_RS03790	COG0482	sulfurtransferase activity
E5Z56_RS03795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5Z56_RS03800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5Z56_RS03805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5Z56_RS03815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5Z56_RS03820	COG1943	Transposase
E5Z56_RS03825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5Z56_RS03830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5Z56_RS03835	COG0165	Argininosuccinate lyase
E5Z56_RS03875	COG0745	RESPONSE REGULATOR receiver
E5Z56_RS03880	COG5002	protein histidine kinase activity
E5Z56_RS03900	COG1592	Rubrerythrin
E5Z56_RS03900	COG1773	rubredoxin
E5Z56_RS03915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5Z56_RS03915	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5Z56_RS03920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5Z56_RS03930	COG0653	protein targeting
E5Z56_RS03940	COG0772	Belongs to the SEDS family
E5Z56_RS03945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5Z56_RS03965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5Z56_RS03975	COG1408	metallophosphoesterase
E5Z56_RS03980	COG1609	Transcriptional regulator
E5Z56_RS03985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5Z56_RS03990	COG0745	RESPONSE REGULATOR receiver
E5Z56_RS03995	COG5002	protein histidine kinase activity
E5Z56_RS04000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Z56_RS04020	COG1185	polyribonucleotide nucleotidyltransferase activity
E5Z56_RS04035	COG3655	Transcriptional regulator
E5Z56_RS04040	COG1596	polysaccharide export
E5Z56_RS04040	COG1555	photosystem II stabilization
E5Z56_RS04060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5Z56_RS04065	COG0180	Tryptophanyl-tRNA synthetase
E5Z56_RS04070	COG1307	EDD domain protein, DegV family
E5Z56_RS04085	COG1136	(ABC) transporter
E5Z56_RS04095	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5Z56_RS04095	COG1918	ferrous iron import across plasma membrane
E5Z56_RS04110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5Z56_RS04120	COG2226	methyltransferase
E5Z56_RS04125	COG0326	Molecular chaperone. Has ATPase activity
E5Z56_RS04145	COG0512	Glutamine amidotransferase of anthranilate synthase
E5Z56_RS04145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5Z56_RS04155	COG0134	indole-3-glycerol-phosphate synthase activity
E5Z56_RS04160	COG0133	tryptophan synthase activity
E5Z56_RS04165	COG0159	tryptophan synthase activity
E5Z56_RS04170	COG0561	phosphatase activity
E5Z56_RS04175	COG0366	Alpha amylase catalytic
E5Z56_RS04175	COG1874	Beta-galactosidase
E5Z56_RS04195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5Z56_RS04250	COG2239	Acts as a magnesium transporter
E5Z56_RS04300	COG0084	hydrolase, TatD family'
E5Z56_RS04305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Z56_RS04305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Z56_RS04325	COG0484	heat shock protein binding
E5Z56_RS04330	COG0443	Heat shock 70 kDa protein
E5Z56_RS04335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5Z56_RS04340	COG1420	regulation of RNA biosynthetic process
E5Z56_RS04350	COG0268	Binds directly to 16S ribosomal RNA
E5Z56_RS04375	COG0525	valine-tRNA ligase activity
E5Z56_RS04415	COG0066	3-isopropylmalate dehydratase activity
E5Z56_RS04420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5Z56_RS04430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Z56_RS04460	COG1131	(ABC) transporter
E5Z56_RS04470	COG0779	Required for maturation of 30S ribosomal subunits
E5Z56_RS04475	COG0195	Participates in both transcription termination and antitermination
E5Z56_RS04480	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E5Z56_RS04490	COG3064	Membrane
E5Z56_RS04490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5Z56_RS04495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5Z56_RS04500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5Z56_RS04515	COG0205	6-phosphofructokinase activity
E5Z56_RS04520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5Z56_RS04535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5Z56_RS04535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5Z56_RS04535	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5Z56_RS04535	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5Z56_RS04545	COG0688	phosphatidylethanolamine metabolic process
E5Z56_RS04550	COG1183	phosphatidylcholine synthase activity
E5Z56_RS04575	COG0463	Glycosyl transferase, family 2
E5Z56_RS04600	COG0196	riboflavin kinase activity
E5Z56_RS04615	COG0367	asparagine synthase
E5Z56_RS04620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5Z56_RS04640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5Z56_RS04645	COG0124	histidyl-tRNA synthetase
E5Z56_RS04650	COG1803	Methylglyoxal synthase
E5Z56_RS04655	COG2894	cell division
E5Z56_RS04660	COG0768	penicillin binding
E5Z56_RS04675	COG1077	Cell shape determining protein MreB Mrl
E5Z56_RS04690	COG0826	peptidase U32
E5Z56_RS04705	COG3103	Sh3 type 3 domain protein
E5Z56_RS04705	COG0366	Alpha amylase catalytic
E5Z56_RS04710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5Z56_RS04715	COG0187	DNA topoisomerase II activity
E5Z56_RS04735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5Z56_RS04745	COG0592	DNA-directed DNA polymerase activity
E5Z56_RS04750	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5Z56_RS04755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5Z56_RS04760	COG0594	ribonuclease P activity
E5Z56_RS04765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5Z56_RS04770	COG0706	membrane insertase activity
E5Z56_RS04775	COG1847	R3H domain protein
E5Z56_RS04780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5Z56_RS04785	COG0445	tRNA wobble uridine modification
E5Z56_RS04795	COG0357	Ribosomal RNA small subunit methyltransferase G
E5Z56_RS04805	COG1192	Involved in chromosome partitioning
E5Z56_RS04810	COG1475	DNA binding
E5Z56_RS04815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5Z56_RS04825	COG0516	GMP reductase activity
E5Z56_RS04825	COG0517	IMP dehydrogenase activity
E5Z56_RS04870	COG1940	carbohydrate kinase activity
E5Z56_RS04875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5Z56_RS04880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5Z56_RS04885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Z56_RS04915	COG0475	glutathione-regulated potassium exporter activity
E5Z56_RS04920	COG3584	3D domain protein
E5Z56_RS04920	COG3583	domain protein
E5Z56_RS04935	COG0037	tRNA processing
E5Z56_RS04995	COG0058	SHG alpha-glucan phosphorylase activity
E5Z56_RS05010	COG1546	Belongs to the CinA family
E5Z56_RS05010	COG1058	Belongs to the CinA family
E5Z56_RS05015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5Z56_RS05020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5Z56_RS05035	COG0028	Belongs to the TPP enzyme family
E5Z56_RS05050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5Z56_RS05055	COG0583	DNA-binding transcription factor activity
E5Z56_RS05060	COG0656	L-ascorbic acid biosynthetic process
E5Z56_RS05065	COG2239	Acts as a magnesium transporter
E5Z56_RS05075	COG3859	Proton-coupled thiamine transporter YuaJ
E5Z56_RS05080	COG0481	GTPase activity
E5Z56_RS05085	COG1316	TRANSCRIPTIONal
E5Z56_RS05090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5Z56_RS05095	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5Z56_RS05100	COG1063	alcohol dehydrogenase
E5Z56_RS05105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5Z56_RS05110	COG2271	Major facilitator Superfamily
E5Z56_RS05115	COG1063	alcohol dehydrogenase
E5Z56_RS05120	COG0191	fructose-bisphosphate aldolase activity
E5Z56_RS05125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5Z56_RS05130	COG0667	Aldo Keto reductase
E5Z56_RS05135	COG1349	DNA-binding transcription factor activity
E5Z56_RS05145	COG0534	Mate efflux family protein
E5Z56_RS05150	COG0733	neurotransmitter:sodium symporter activity
E5Z56_RS05185	COG0745	RESPONSE REGULATOR receiver
E5Z56_RS05185	COG2972	Histidine kinase
E5Z56_RS05215	COG1061	Type III restriction enzyme res subunit
E5Z56_RS05220	COG0494	nUDIX hydrolase
E5Z56_RS05245	COG4372	Transposase
E5Z56_RS05290	COG4372	Transposase
E5Z56_RS05355	COG4475	Protein of unknown function (DUF436)
E5Z56_RS05360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5Z56_RS05435	COG5433	transposase activity
E5Z56_RS05440	COG0071	Belongs to the small heat shock protein (HSP20) family
E5Z56_RS05455	COG1192	Involved in chromosome partitioning
E5Z56_RS05460	COG1475	DNA binding
E5Z56_RS05495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5Z56_RS05575	COG4509	Sortase family
E5Z56_RS05615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5Z56_RS05625	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5Z56_RS05670	COG1846	Transcriptional regulator
E5Z56_RS05685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5Z56_RS05725	COG0582	viral genome integration into host DNA
E5Z56_RS05755	COG1175	transmembrane transport
E5Z56_RS05760	COG3833	ABC-type maltose transport systems, permease component
E5Z56_RS05775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5Z56_RS05780	COG2720	vancomycin resistance protein
E5Z56_RS05795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5Z56_RS05810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Z56_RS05820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5Z56_RS05830	COG0366	Alpha amylase catalytic
E5Z56_RS05840	COG0640	Transcriptional regulator
E5Z56_RS05860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E5Z56_RS05865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5Z56_RS05875	COG3958	Transketolase
E5Z56_RS05880	COG0252	asparaginase activity
E5Z56_RS05890	COG0658	competence protein
E5Z56_RS05890	COG2333	competence protein COMEC
E5Z56_RS05895	COG1136	(ABC) transporter
E5Z56_RS05900	COG0577	efflux transmembrane transporter activity
E5Z56_RS05905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5Z56_RS05915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5Z56_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z56_RS05925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5Z56_RS05935	COG4120	Belongs to the binding-protein-dependent transport system permease family
E5Z56_RS05940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5Z56_RS05950	COG1511	domain protein
E5Z56_RS05950	COG1511	domain protein
E5Z56_RS05955	COG5492	domain, Protein
E5Z56_RS05975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5Z56_RS05985	COG0039	L-malate dehydrogenase activity
E5Z56_RS06010	COG0569	domain protein
E5Z56_RS06040	COG1088	dTDP-glucose 4,6-dehydratase activity
E5Z56_RS06045	COG1091	dTDP-4-dehydrorhamnose reductase activity
E5Z56_RS06060	COG0438	transferase activity, transferring glycosyl groups
E5Z56_RS06065	COG1216	Glycosyl transferase, family 2
E5Z56_RS06065	COG1442	glycosyl transferase family 8
E5Z56_RS06070	COG0438	transferase activity, transferring glycosyl groups
E5Z56_RS06080	COG1216	Glycosyl transferase, family 2
E5Z56_RS06080	COG1442	glycosyl transferase family 8
E5Z56_RS06110	COG1193	negative regulation of DNA recombination
E5Z56_RS06115	COG1381	Involved in DNA repair and RecF pathway recombination
E5Z56_RS06120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5Z56_RS06125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5Z56_RS06140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5Z56_RS06145	COG0228	four-way junction DNA binding
E5Z56_RS06150	COG1837	Belongs to the UPF0109 family
E5Z56_RS06165	COG0336	Belongs to the RNA methyltransferase TrmD family
E5Z56_RS06175	COG0322	excinuclease ABC activity
E5Z56_RS06180	COG0742	ribosomal rna small subunit methyltransferase
E5Z56_RS06185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5Z56_RS06195	COG2001	Belongs to the MraZ family
E5Z56_RS06200	COG0275	rRNA processing
E5Z56_RS06210	COG0768	penicillin binding
E5Z56_RS06220	COG0772	Belongs to the SEDS family
E5Z56_RS06225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5Z56_RS06240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5Z56_RS06250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5Z56_RS06255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5Z56_RS06285	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5Z56_RS06290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5Z56_RS06295	COG0284	orotidine-5'-phosphate decarboxylase activity
E5Z56_RS06305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5Z56_RS06315	COG1472	Belongs to the glycosyl hydrolase 3 family
E5Z56_RS06320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5Z56_RS06325	COG2340	Cysteine-rich secretory protein family
E5Z56_RS06340	COG0148	phosphopyruvate hydratase activity
E5Z56_RS06390	COG3118	belongs to the thioredoxin family
E5Z56_RS06410	COG1611	Belongs to the LOG family
E5Z56_RS06420	COG1523	belongs to the glycosyl hydrolase 13 family
E5Z56_RS06460	COG1104	cysteine desulfurase activity
E5Z56_RS06465	COG0301	tRNA thio-modification
E5Z56_RS06470	COG4509	Sortase family
E5Z56_RS06485	COG0038	chloride channel
E5Z56_RS06490	COG0085	RNA polymerase activity
E5Z56_RS06495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5Z56_RS06500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5Z56_RS06505	COG0049	tRNA binding
E5Z56_RS06510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5Z56_RS06515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5Z56_RS06530	COG3906	Belongs to the UPF0473 family
E5Z56_RS06540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Z56_RS06545	COG0456	acetyltransferase
E5Z56_RS06550	COG1396	sequence-specific DNA binding
E5Z56_RS06555	COG1605	Chorismate mutase
E5Z56_RS06555	COG0077	Prephenate dehydratase
E5Z56_RS06560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5Z56_RS06565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5Z56_RS06570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5Z56_RS06580	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E5Z56_RS06590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5Z56_RS06595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5Z56_RS06600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5Z56_RS06605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5Z56_RS06610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E5Z56_RS06625	COG1366	Belongs to the anti-sigma-factor antagonist family
E5Z56_RS06635	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5Z56_RS06640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5Z56_RS06650	COG1774	PSP1 C-terminal conserved region
E5Z56_RS06655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5Z56_RS06680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5Z56_RS06710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5Z56_RS06735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5Z56_RS06765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5Z56_RS06780	COG1362	aminopeptidase activity
E5Z56_RS06795	COG2826	transposase and inactivated derivatives, IS30 family
E5Z56_RS06805	COG0726	polysaccharide deacetylase
E5Z56_RS06820	COG2852	Protein conserved in bacteria
E5Z56_RS06825	COG2826	transposase and inactivated derivatives, IS30 family
E5Z56_RS06830	COG2826	transposase and inactivated derivatives, IS30 family
E5Z56_RS06840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Z56_RS06910	COG0671	phosphoesterase, PA-phosphatase related
E5Z56_RS06925	COG0051	transcription antitermination factor activity, RNA binding
E5Z56_RS06930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5Z56_RS06940	COG0089	rRNA binding
E5Z56_RS06950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5Z56_RS06960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5Z56_RS06965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5Z56_RS06970	COG0255	Belongs to the universal ribosomal protein uL29 family
E5Z56_RS06975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5Z56_RS06980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5Z56_RS06990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5Z56_RS06995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5Z56_RS07000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5Z56_RS07005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5Z56_RS07010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5Z56_RS07015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5Z56_RS07030	COG0201	protein transport
E5Z56_RS07035	COG0563	adenylate kinase activity
E5Z56_RS07050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5Z56_RS07060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5Z56_RS07070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5Z56_RS07075	COG0202	RNA polymerase activity
E5Z56_RS07080	COG0203	ribosomal protein L17
E5Z56_RS07095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5Z56_RS07105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5Z56_RS07110	COG0297	glycogen (starch) synthase activity
E5Z56_RS07120	COG1573	uracil-dna glycosylase
E5Z56_RS07125	COG4869	propanediol catabolic process
E5Z56_RS07140	COG0250	Participates in transcription elongation, termination and antitermination
E5Z56_RS07145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5Z56_RS07155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5Z56_RS07175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5Z56_RS07185	COG0018	arginyl-trna synthetase
E5Z56_RS07200	COG1131	(ABC) transporter
E5Z56_RS07215	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E5Z56_RS07230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5Z56_RS07240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5Z56_RS07250	COG1874	Beta-galactosidase
E5Z56_RS07250	COG0366	Alpha amylase catalytic
E5Z56_RS07280	COG0154	amidase activity
E5Z56_RS07285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5Z56_RS07305	COG0504	CTP synthase activity
E5Z56_RS07310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5Z56_RS07330	COG0004	ammonium transporteR
E5Z56_RS07335	COG2826	transposase and inactivated derivatives, IS30 family
E5Z56_RS07355	COG0460	homoserine dehydrogenase
E5Z56_RS07370	COG2070	2-Nitropropane dioxygenase
E5Z56_RS07375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5Z56_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
E5Z56_RS07385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5Z56_RS07390	COG0511	ligase activity, forming carbon-carbon bonds
E5Z56_RS07395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5Z56_RS07400	COG0439	Biotin carboxylase
E5Z56_RS07405	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5Z56_RS07410	COG0825	malonyl-CoA metabolic process
E5Z56_RS07415	COG5002	protein histidine kinase activity
E5Z56_RS07420	COG0745	RESPONSE REGULATOR receiver
E5Z56_RS07445	COG1690	Belongs to the RtcB family
E5Z56_RS07490	COG1595	DNA-templated transcription, initiation
E5Z56_RS07515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5Z56_RS07545	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E5Z56_RS07595	COG0513	Belongs to the DEAD box helicase family
E5Z56_RS07660	COG4974	Belongs to the 'phage' integrase family
E5Z56_RS07695	COG0582	viral genome integration into host DNA
E5Z56_RS07720	COG4372	Transposase
E5Z56_RS07815	COG1475	DNA binding
E5Z56_RS07920	COG1131	(ABC) transporter
E5Z56_RS07965	COG4716	Myosin-crossreactive antigen
E5Z56_RS08000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5Z56_RS08005	COG0655	NAD(P)H dehydrogenase (quinone) activity
E5Z56_RS08045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E5Z56_RS08060	COG0351	phosphomethylpyrimidine kinase
E5Z56_RS08060	COG0352	thiamine-phosphate diphosphorylase activity
E5Z56_RS08075	COG0583	DNA-binding transcription factor activity
E5Z56_RS08080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5Z56_RS08090	COG0708	Exodeoxyribonuclease III
E5Z56_RS08115	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5Z56_RS08120	COG0546	phosphoglycolate phosphatase activity
E5Z56_RS08130	COG1077	Cell shape determining protein MreB Mrl
E5Z56_RS08140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Z56_RS08160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5Z56_RS08170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5Z56_RS08180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5Z56_RS08190	COG1686	Belongs to the peptidase S11 family
E5Z56_RS08195	COG0166	Belongs to the GPI family
E5Z56_RS08220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5Z56_RS08225	COG1160	GTP binding
E5Z56_RS08230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5Z56_RS08235	COG0537	adenosine 5'-monophosphoramidase activity
E5Z56_RS08240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Z56_RS08270	COG1253	flavin adenine dinucleotide binding
E5Z56_RS08275	COG0740	serine-type endopeptidase activity
E5Z56_RS08280	COG1968	undecaprenyl-diphosphatase activity
E5Z56_RS08295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5Z56_RS08305	COG0534	Mate efflux family protein
E5Z56_RS08340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5Z56_RS08345	COG0328	RNA-DNA hybrid ribonuclease activity
E5Z56_RS08350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5Z56_RS08355	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E5Z56_RS08360	COG0359	binds to the 23S rRNA
E5Z56_RS08365	COG0305	Participates in initiation and elongation during chromosome replication
E5Z56_RS08395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5Z56_RS08415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5Z56_RS08420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5Z56_RS08425	COG0826	peptidase U32
E5Z56_RS08430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5Z56_RS08445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5Z56_RS08450	COG1994	Peptidase M50
E5Z56_RS08455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5Z56_RS08460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5Z56_RS08470	COG3874	Sporulation protein YtfJ
E5Z56_RS08475	COG1686	Belongs to the peptidase S11 family
E5Z56_RS08480	COG1187	pseudouridine synthase activity
E5Z56_RS08485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5Z56_RS08490	COG0511	ligase activity, forming carbon-carbon bonds
E5Z56_RS08495	COG5016	pyruvate
E5Z56_RS08495	COG0511	ligase activity, forming carbon-carbon bonds
E5Z56_RS08505	COG1323	Belongs to the UPF0348 family
E5Z56_RS08510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5Z56_RS08585	COG4372	Transposase
E5Z56_RS08650	COG4372	Transposase
E5Z56_RS08665	COG2155	Conserved Protein
E5Z56_RS08700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5Z56_RS08705	COG1132	(ABC) transporter
E5Z56_RS08710	COG1132	(ABC) transporter
E5Z56_RS08735	COG2032	superoxide dismutase activity
E5Z56_RS08770	COG0582	viral genome integration into host DNA
E5Z56_RS08785	COG1373	ATPase (AAA superfamily
E5Z56_RS08795	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5Z56_RS08805	COG0732	type I restriction modification DNA specificity domain
E5Z56_RS08815	COG0732	type I restriction modification DNA specificity domain
E5Z56_RS08825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5Z56_RS08860	COG0612	Peptidase, M16
E5Z56_RS08865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5Z56_RS08870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5Z56_RS08875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5Z56_RS08885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5Z56_RS08895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5Z56_RS08915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5Z56_RS08955	COG1132	(ABC) transporter
E5Z56_RS08965	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E5Z56_RS08985	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E5Z56_RS08995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5Z56_RS09000	COG1217	gtp-binding protein TYPA
E5Z56_RS09010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5Z56_RS09015	COG0765	amino acid transport
E5Z56_RS09040	COG1496	oxidoreductase activity
E5Z56_RS09045	COG0564	pseudouridine synthase activity
E5Z56_RS09060	COG2184	nucleotidyltransferase activity
E5Z56_RS09070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5Z56_RS09080	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E5Z56_RS09090	COG0489	protein tyrosine kinase activity
E5Z56_RS09095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5Z56_RS09100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5Z56_RS09105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5Z56_RS09110	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5Z56_RS09115	COG1121	(ABC) transporter
E5Z56_RS09120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5Z56_RS09130	COG2323	membrane
E5Z56_RS09135	COG0697	spore germination
E5Z56_RS09150	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5Z56_RS09155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5Z56_RS09160	COG1660	Displays ATPase and GTPase activities
E5Z56_RS09165	COG1481	regulation of sporulation
E5Z56_RS09170	COG1722	exodeoxyribonuclease VII activity
E5Z56_RS09175	COG0142	geranyltranstransferase activity
E5Z56_RS09180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5Z56_RS09185	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E5Z56_RS09195	COG1438	arginine binding
E5Z56_RS09200	COG0497	DNA recombination
E5Z56_RS09205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E5Z56_RS09205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5Z56_RS09210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5Z56_RS09215	COG1490	D-aminoacyl-tRNA deacylase activity
E5Z56_RS09220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Z56_RS09225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Z56_RS09240	COG3956	TIGRFAM MazG family protein
E5Z56_RS09245	COG0776	regulation of translation
E5Z56_RS09250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5Z56_RS09270	COG1098	S1 RNA binding domain
E5Z56_RS09280	COG0116	Belongs to the methyltransferase superfamily
E5Z56_RS09285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5Z56_RS09290	COG0459	protein refolding
E5Z56_RS09300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5Z56_RS09310	COG3906	Belongs to the UPF0473 family
E5Z56_RS09330	COG1522	sequence-specific DNA binding
E5Z56_RS09335	COG0436	Aminotransferase
E5Z56_RS09340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5Z56_RS09350	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E5Z56_RS09355	COG1074	ATP-dependent DNA helicase activity
E5Z56_RS09360	COG0300	oxidoreductase activity
E5Z56_RS09375	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E5Z56_RS09380	COG2081	HI0933 family
E5Z56_RS09420	COG1242	4 iron, 4 sulfur cluster binding
E5Z56_RS09425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5Z56_RS09435	COG4208	sulfate ABC transporter
E5Z56_RS09440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5Z56_RS09445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5Z56_RS09450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5Z56_RS09450	COG1648	precorrin-2 dehydrogenase activity
E5Z56_RS09465	COG0113	porphobilinogen synthase activity
E5Z56_RS09470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5Z56_RS09480	COG2873	o-acetylhomoserine
E5Z56_RS09495	COG3118	belongs to the thioredoxin family
E5Z56_RS09505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5Z56_RS09515	COG0492	ferredoxin-NADP+ reductase activity
E5Z56_RS09520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5Z56_RS09525	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
E5Z56_RS09530	COG0175	sulfate reduction
E5Z56_RS09535	COG2895	sulfate adenylyltransferase (ATP) activity
E5Z56_RS09560	COG0697	spore germination
E5Z56_RS09570	COG0772	Belongs to the SEDS family
E5Z56_RS09575	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5Z56_RS09585	COG1214	PFAM Peptidase M22, glycoprotease
E5Z56_RS09590	COG0698	ribose 5-phosphate isomerase
E5Z56_RS09595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5Z56_RS09605	COG2855	membrane
E5Z56_RS09610	COG0540	Belongs to the ATCase OTCase family
E5Z56_RS09620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5Z56_RS09625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5Z56_RS09630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5Z56_RS09635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5Z56_RS09640	COG0519	Catalyzes the synthesis of GMP from XMP
E5Z56_RS09655	COG0582	viral genome integration into host DNA
E5Z56_RS09700	COG5002	protein histidine kinase activity
E5Z56_RS09770	COG4372	Transposase
E5Z56_RS09800	COG0517	IMP dehydrogenase activity
E5Z56_RS09800	COG1125	glycine betaine transport
E5Z56_RS09805	COG1732	Glycine betaine
E5Z56_RS09820	COG1733	regulation of RNA biosynthetic process
E5Z56_RS09825	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
E5Z56_RS09830	COG1518	maintenance of DNA repeat elements
E5Z56_RS09835	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E5Z56_RS09850	COG2801	Transposase and inactivated derivatives
E5Z56_RS09860	COG4509	Sortase family
E5Z56_RS09875	COG4509	Sortase family
E5Z56_RS09930	COG1475	DNA binding
E5Z56_RS09960	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E5Z56_RS09965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5Z56_RS09965	COG1918	ferrous iron import across plasma membrane
E5Z56_RS09980	COG0534	Mate efflux family protein
E5Z56_RS09985	COG0667	Aldo Keto reductase
E5Z56_RS09990	COG2183	response to ionizing radiation
E5Z56_RS10005	COG2003	Belongs to the UPF0758 family
E5Z56_RS10010	COG0556	nucleotide-excision repair
E5Z56_RS10015	COG0187	DNA topoisomerase II activity
E5Z56_RS10020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5Z56_RS10025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5Z56_RS10055	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5Z56_RS10060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5Z56_RS10065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5Z56_RS10070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5Z56_RS10080	COG0138	bifunctional purine biosynthesis protein purh
E5Z56_RS10085	COG0151	Belongs to the GarS family
E5Z56_RS10090	COG0534	Mate efflux family protein
E5Z56_RS10095	COG0656	L-ascorbic acid biosynthetic process
E5Z56_RS10110	COG0667	Aldo Keto reductase
E5Z56_RS10115	COG1979	alcohol dehydrogenase
E5Z56_RS10125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5Z56_RS10135	COG2826	transposase and inactivated derivatives, IS30 family
E5Z56_RS10140	COG1649	PFAM Uncharacterised BCR, COG1649
E5Z56_RS10150	COG0564	pseudouridine synthase activity
E5Z56_RS10155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5Z56_RS10165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5Z56_RS10180	COG1862	Preprotein translocase
E5Z56_RS10190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5Z56_RS10200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5Z56_RS10205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5Z56_RS10220	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E5Z56_RS10230	COG0069	glutamate synthase activity
E5Z56_RS10230	COG0067	glutamate synthase
E5Z56_RS10230	COG0070	glutamate synthase
E5Z56_RS10235	COG0493	'glutamate synthase
E5Z56_RS10245	COG3773	Cell wall hydrolase
E5Z56_RS10255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Z56_RS10260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5Z56_RS10265	COG1151	hydroxylamine reductase activity
E5Z56_RS10290	COG0583	DNA-binding transcription factor activity
E5Z56_RS10315	COG1132	(ABC) transporter
E5Z56_RS10320	COG1132	(ABC) transporter
E5Z56_RS10325	COG0534	Mate efflux family protein
E5Z56_RS10330	COG2508	Transcriptional regulator
E5Z56_RS10335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5Z56_RS10340	COG0833	amino acid
E5Z56_RS10345	COG1454	alcohol dehydrogenase
E5Z56_RS10365	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5Z56_RS10395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5Z56_RS10400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5Z56_RS10445	COG0778	Nitroreductase
E5Z56_RS10450	COG1523	belongs to the glycosyl hydrolase 13 family
E5Z56_RS10455	COG3177	Filamentation induced by cAMP protein fic
E5Z56_RS10465	COG3279	Response regulator of the LytR AlgR family
E5Z56_RS10500	COG1136	(ABC) transporter
E5Z56_RS10500	COG0577	efflux transmembrane transporter activity
E5Z56_RS10520	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5Z56_RS10525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E5Z56_RS10535	COG4974	Belongs to the 'phage' integrase family
E5Z56_RS10575	COG1131	(ABC) transporter
E5Z56_RS10620	COG1215	transferase activity, transferring glycosyl groups
E5Z56_RS10635	COG2208	phosphoserine phosphatase activity
E5Z56_RS10635	COG2770	Histidine kinase
E5Z56_RS10670	COG0583	DNA-binding transcription factor activity
E5Z56_RS10680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5Z56_RS10685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5Z56_RS10700	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5Z56_RS10725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5Z56_RS10740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5Z56_RS10760	COG0786	glutamate:sodium symporter activity
E5Z56_RS10770	COG1177	transmembrane transport
E5Z56_RS10775	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5Z56_RS10780	COG3842	ATPase activity
E5Z56_RS10785	COG2116	formate transmembrane transporter activity
E5Z56_RS10855	COG4372	Transposase
E5Z56_RS10885	COG0681	Belongs to the peptidase S26 family
E5Z56_RS10895	COG0335	large ribosomal subunit rRNA binding
E5Z56_RS10900	COG0564	pseudouridine synthase activity
E5Z56_RS10905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5Z56_RS10910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5Z56_RS10925	COG1799	cell septum assembly
E5Z56_RS10930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5Z56_RS10945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5Z56_RS10950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5Z56_RS10960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5Z56_RS10975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5Z56_RS10980	COG0006	proline dipeptidase activity
E5Z56_RS10985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5Z56_RS10995	COG0495	leucyl-tRNA aminoacylation
E5Z56_RS11000	COG0799	negative regulation of ribosome biogenesis
E5Z56_RS11005	COG1713	HD superfamily hydrolase involved in NAD metabolism
E5Z56_RS11020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5Z56_RS11025	COG0552	protein localization to endoplasmic reticulum
E5Z56_RS11030	COG1196	nuclear chromosome segregation
E5Z56_RS11045	COG0416	fatty acid biosynthetic process
E5Z56_RS11050	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E5Z56_RS11055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5Z56_RS11060	COG0758	DNA mediated transformation
E5Z56_RS11065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Z56_RS11070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5Z56_RS11075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5Z56_RS11090	COG0590	tRNA wobble adenosine to inosine editing
E5Z56_RS11095	COG2315	Protein conserved in bacteria
E5Z56_RS11100	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E5Z56_RS11110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5Z56_RS11125	COG0281	malic enzyme
E5Z56_RS11135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5Z56_RS11140	COG0750	zinc metalloprotease
E5Z56_RS11145	COG0745	RESPONSE REGULATOR receiver
E5Z56_RS11150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5Z56_RS11155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5Z56_RS11160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5Z56_RS11165	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E5Z56_RS11170	COG0628	permease
E5Z56_RS11185	COG0750	zinc metalloprotease
E5Z56_RS11190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5Z56_RS11195	COG4589	Belongs to the CDS family
E5Z56_RS11205	COG0233	cytoplasmic translational termination
E5Z56_RS11210	COG0528	UMP kinase activity
E5Z56_RS11215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5Z56_RS11220	COG0052	Belongs to the universal ribosomal protein uS2 family
E5Z56_RS11240	COG1873	PFAM PRC-barrel domain
E5Z56_RS11260	COG1191	sigma factor activity
E5Z56_RS11285	COG1570	exodeoxyribonuclease VII activity
E5Z56_RS11290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5Z56_RS11295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5Z56_RS11335	COG3854	ATPases associated with a variety of cellular activities
E5Z56_RS11340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5Z56_RS11350	COG4475	Protein of unknown function (DUF436)
E5Z56_RS11355	COG0539	negative regulation of cytoplasmic translation
E5Z56_RS11355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5Z56_RS11360	COG0204	Acyl-transferase
E5Z56_RS11365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5Z56_RS11380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5Z56_RS11385	COG0107	imidazoleglycerol-phosphate synthase activity
E5Z56_RS11415	COG0352	thiamine-phosphate diphosphorylase activity
E5Z56_RS11425	COG2022	thiamine diphosphate biosynthetic process
E5Z56_RS11440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5Z56_RS11455	COG1162	GTPase activity
E5Z56_RS11460	COG0515	serine threonine protein kinase
E5Z56_RS11460	COG2815	serine threonine protein kinase
E5Z56_RS11470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5Z56_RS11475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5Z56_RS11475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5Z56_RS11485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5Z56_RS11490	COG0242	peptide deformylase activity
E5Z56_RS11500	COG1758	RNA polymerase activity
E5Z56_RS11505	COG0194	GDP metabolic process
E5Z56_RS11510	COG2052	Domain of unknown function (DUF370)
E5Z56_RS11520	COG0217	transcriptional regulatory protein
E5Z56_RS11535	COG0534	Mate efflux family protein
E5Z56_RS11540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII