locus-tag	class	description
DW349_RS00010	COG0592	DNA-directed DNA polymerase activity
DW349_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DW349_RS00030	COG0678	peroxiredoxin activity
DW349_RS00035	COG0784	Response regulator, receiver
DW349_RS00035	COG5002	protein histidine kinase activity
DW349_RS00050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DW349_RS00060	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DW349_RS00085	COG0534	Mate efflux family protein
DW349_RS00090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DW349_RS00095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DW349_RS00120	COG1612	heme a metabolic process
DW349_RS00125	COG0109	protoheme IX farnesyltransferase activity
DW349_RS00135	COG2311	Membrane
DW349_RS00140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DW349_RS00150	COG1490	D-aminoacyl-tRNA deacylase activity
DW349_RS00165	COG0519	Catalyzes the synthesis of GMP from XMP
DW349_RS00165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DW349_RS00170	COG0583	DNA-binding transcription factor activity
DW349_RS00175	COG3085	chromosome segregation
DW349_RS00180	COG2885	chlorophyll binding
DW349_RS00180	COG3047	cAMP biosynthetic process
DW349_RS00210	COG3290	protein histidine kinase activity
DW349_RS00240	COG1272	protein, Hemolysin III
DW349_RS00250	COG1609	Transcriptional regulator
DW349_RS00255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DW349_RS00265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DW349_RS00280	COG0745	RESPONSE REGULATOR receiver
DW349_RS00285	COG2205	protein histidine kinase activity
DW349_RS00295	COG0737	Belongs to the 5'-nucleotidase family
DW349_RS00310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DW349_RS00315	COG2003	Belongs to the UPF0758 family
DW349_RS00320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DW349_RS00330	COG2226	methyltransferase
DW349_RS00335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DW349_RS00340	COG0259	pyridoxamine-phosphate oxidase activity
DW349_RS00355	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DW349_RS00360	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DW349_RS00365	COG0709	Synthesizes selenophosphate from selenide and ATP
DW349_RS00370	COG2183	response to ionizing radiation
DW349_RS00415	COG0488	(ABC) transporter
DW349_RS00420	COG0740	serine-type endopeptidase activity
DW349_RS00450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DW349_RS00455	COG0140	phosphoribosyl-ATP diphosphatase activity
DW349_RS00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DW349_RS00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DW349_RS00485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DW349_RS00495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DW349_RS00495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DW349_RS00500	COG3265	gluconokinase activity
DW349_RS00505	COG1609	Transcriptional regulator
DW349_RS00545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DW349_RS00550	COG2764	glyoxalase bleomycin resistance protein dioxygenase
DW349_RS00560	COG3795	YCII-related domain
DW349_RS00565	COG4941	Belongs to the sigma-70 factor family
DW349_RS00575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DW349_RS00590	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DW349_RS00595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DW349_RS00605	COG0450	alkyl hydroperoxide reductase
DW349_RS00615	COG0840	transmembrane signaling receptor activity
DW349_RS00625	COG0745	RESPONSE REGULATOR receiver
DW349_RS00630	COG0745	RESPONSE REGULATOR receiver
DW349_RS00635	COG0643	Histidine kinase
DW349_RS00635	COG2198	Histidine kinase
DW349_RS00640	COG0835	chemotaxis
DW349_RS00645	COG0840	transmembrane signaling receptor activity
DW349_RS00655	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DW349_RS00660	COG2201	protein-glutamate methylesterase activity
DW349_RS00670	COG0006	proline dipeptidase activity
DW349_RS00675	COG3079	Belongs to the UPF0149 family
DW349_RS00695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DW349_RS00705	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DW349_RS00710	COG1119	ATPase activity
DW349_RS00715	COG0456	acetyltransferase
DW349_RS00720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DW349_RS00725	COG0784	Response regulator, receiver
DW349_RS00725	COG5002	protein histidine kinase activity
DW349_RS00740	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DW349_RS00745	COG1214	PFAM Peptidase M22, glycoprotease
DW349_RS00745	COG0456	acetyltransferase
DW349_RS00755	COG0456	acetyltransferase
DW349_RS00780	COG0210	DNA helicase
DW349_RS00790	COG3423	Transcriptional regulator
DW349_RS00830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DW349_RS00835	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DW349_RS00845	COG0789	Transcriptional regulator
DW349_RS00855	COG1192	Involved in chromosome partitioning
DW349_RS00875	COG0643	Histidine kinase
DW349_RS00875	COG2198	Histidine kinase
DW349_RS00880	COG0840	transmembrane signaling receptor activity
DW349_RS00885	COG0835	chemotaxis
DW349_RS00895	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DW349_RS00900	COG2201	protein-glutamate methylesterase activity
DW349_RS00915	COG1132	(ABC) transporter
DW349_RS00935	COG0667	Aldo Keto reductase
DW349_RS00940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DW349_RS00950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DW349_RS00955	COG0778	Nitroreductase
DW349_RS00960	COG0596	Alpha beta hydrolase
DW349_RS00965	COG0251	oxidation-reduction process
DW349_RS00970	COG1335	isochorismatase
DW349_RS00980	COG1309	transcriptional regulator
DW349_RS00995	COG0006	proline dipeptidase activity
DW349_RS01000	COG3842	ATPase activity
DW349_RS01010	COG1840	ABC-type Fe3 transport system, periplasmic component
DW349_RS01020	COG1280	lysine exporter protein (LysE YggA)
DW349_RS01025	COG0583	DNA-binding transcription factor activity
DW349_RS01050	COG4597	amino acid ABC transporter
DW349_RS01055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DW349_RS01060	COG2204	response regulator
DW349_RS01065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DW349_RS01065	COG4191	Histidine kinase
DW349_RS01085	COG2239	Acts as a magnesium transporter
DW349_RS01095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DW349_RS01115	COG0398	Pfam SNARE associated Golgi protein
DW349_RS01135	COG1073	alpha beta
DW349_RS01140	COG0606	chelatase, subunit chli
DW349_RS01145	COG0028	Belongs to the TPP enzyme family
DW349_RS01170	COG0702	epimerase
DW349_RS01175	COG2200	EAL domain
DW349_RS01175	COG2199	diguanylate cyclase activity
DW349_RS01175	COG3287	FIST C domain
DW349_RS01180	COG2827	Endonuclease containing a URI domain
DW349_RS01185	COG0737	Belongs to the 5'-nucleotidase family
DW349_RS01190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DW349_RS01200	COG0179	Fumarylacetoacetate (FAA) hydrolase
DW349_RS01210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DW349_RS01220	COG0640	Transcriptional regulator
DW349_RS01230	COG0791	NLP P60 protein
DW349_RS01240	COG0445	tRNA wobble uridine modification
DW349_RS01245	COG0357	Ribosomal RNA small subunit methyltransferase G
DW349_RS01250	COG1192	Involved in chromosome partitioning
DW349_RS01255	COG1475	DNA binding
DW349_RS01275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DW349_RS01285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DW349_RS01295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DW349_RS01300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DW349_RS01305	COG0583	DNA-binding transcription factor activity
DW349_RS01315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DW349_RS01320	COG4106	trans-aconitate 2-methyltransferase activity
DW349_RS01325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DW349_RS01335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DW349_RS01345	COG0723	plastoquinol--plastocyanin reductase activity
DW349_RS01350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DW349_RS01355	COG2857	Cytochrome c1
DW349_RS01360	COG0625	glutathione transferase activity
DW349_RS01365	COG2969	positive regulation of protein catabolic process
DW349_RS01405	COG0435	Glutathione S-transferase
DW349_RS01410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DW349_RS01415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DW349_RS01420	COG1067	ATP-dependent peptidase activity
DW349_RS01425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DW349_RS01440	COG2198	Histidine kinase
DW349_RS01440	COG2205	protein histidine kinase activity
DW349_RS01440	COG0784	Response regulator, receiver
DW349_RS01445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DW349_RS01465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DW349_RS01470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DW349_RS01490	COG0494	nUDIX hydrolase
DW349_RS01500	COG5001	Diguanylate cyclase
DW349_RS01500	COG3706	GGDEF domain
DW349_RS01500	COG2203	Gaf domain
DW349_RS01500	COG4251	negative regulation of phosphorylation
DW349_RS01510	COG0210	DNA helicase
DW349_RS01565	COG0714	Associated with various cellular activities
DW349_RS01585	COG2304	oxidoreductase activity
DW349_RS01600	COG1217	gtp-binding protein TYPA
DW349_RS01610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DW349_RS01615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DW349_RS01630	COG0640	Transcriptional regulator
DW349_RS01665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DW349_RS01670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DW349_RS01675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DW349_RS01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW349_RS01705	COG2207	Transcriptional regulator
DW349_RS01710	COG0456	acetyltransferase
DW349_RS01715	COG2205	protein histidine kinase activity
DW349_RS01720	COG0745	RESPONSE REGULATOR receiver
DW349_RS01725	COG2840	Smr protein MutS2
DW349_RS01740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DW349_RS01745	COG1981	membrane
DW349_RS01775	COG0739	heme binding
DW349_RS01780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DW349_RS01810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DW349_RS01820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DW349_RS01820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DW349_RS01825	COG4221	oxidoreductase activity
DW349_RS01895	COG1733	regulation of RNA biosynthetic process
DW349_RS01900	COG0702	epimerase
DW349_RS01930	COG2329	Antibiotic biosynthesis monooxygenase
DW349_RS01935	COG2375	cellular response to nickel ion
DW349_RS01970	COG2226	methyltransferase
DW349_RS01980	COG1666	GTP binding
DW349_RS02030	COG0411	ABC transporter
DW349_RS02040	COG1012	belongs to the aldehyde dehydrogenase family
DW349_RS02045	COG2268	Band 7 protein
DW349_RS02075	COG1234	tRNA 3'-trailer cleavage
DW349_RS02110	COG0596	Alpha beta hydrolase
DW349_RS02130	COG1741	Belongs to the pirin family
DW349_RS02155	COG2308	Evidence 4 Homologs of previously reported genes of
DW349_RS02190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DW349_RS02210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DW349_RS02215	COG0246	Mannitol dehydrogenase
DW349_RS02220	COG4948	Mandelate Racemase Muconate Lactonizing
DW349_RS02225	COG1904	glucuronate isomerase
DW349_RS02230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DW349_RS02240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DW349_RS02245	COG1802	Transcriptional regulator
DW349_RS02250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DW349_RS02275	COG0402	S-adenosylhomocysteine deaminase activity
DW349_RS02280	COG0778	Nitroreductase
DW349_RS02300	COG3485	protocatechuate 3,4-dioxygenase
DW349_RS02330	COG2205	protein histidine kinase activity
DW349_RS02330	COG5002	protein histidine kinase activity
DW349_RS02330	COG0784	Response regulator, receiver
DW349_RS02350	COG0655	NAD(P)H dehydrogenase (quinone) activity
DW349_RS02360	COG0457	Tetratricopeptide repeat
DW349_RS02370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DW349_RS02375	COG1012	belongs to the aldehyde dehydrogenase family
DW349_RS02380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DW349_RS02390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DW349_RS02440	COG0174	glutamine synthetase
DW349_RS02445	COG1012	belongs to the aldehyde dehydrogenase family
DW349_RS02450	COG0174	glutamine synthetase
DW349_RS02465	COG3842	ATPase activity
DW349_RS02470	COG1176	ABC-type spermidine putrescine transport system, permease component I
DW349_RS02475	COG1177	transmembrane transport
DW349_RS02480	COG0840	transmembrane signaling receptor activity
DW349_RS02485	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DW349_RS02485	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DW349_RS02490	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DW349_RS02515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DW349_RS02535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DW349_RS02540	COG0081	regulation of translation
DW349_RS02545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DW349_RS02550	COG0222	ribosome binding
DW349_RS02555	COG0085	RNA polymerase activity
DW349_RS02565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DW349_RS02570	COG0049	tRNA binding
DW349_RS02575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DW349_RS02580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DW349_RS02590	COG0051	transcription antitermination factor activity, RNA binding
DW349_RS02595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DW349_RS02600	COG0088	Forms part of the polypeptide exit tunnel
DW349_RS02605	COG0089	rRNA binding
DW349_RS02610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DW349_RS02615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DW349_RS02620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DW349_RS02625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DW349_RS02630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DW349_RS02640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DW349_RS02645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DW349_RS02650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DW349_RS02655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DW349_RS02660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DW349_RS02665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DW349_RS02670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DW349_RS02675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DW349_RS02680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DW349_RS02685	COG1841	ribosomal large subunit assembly
DW349_RS02690	COG0200	Binds to the 23S rRNA
DW349_RS02700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DW349_RS02710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DW349_RS02715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DW349_RS02720	COG0202	RNA polymerase activity
DW349_RS02735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DW349_RS02740	COG0501	Belongs to the peptidase M48B family
DW349_RS02745	COG2204	response regulator
DW349_RS02755	COG2205	protein histidine kinase activity
DW349_RS02770	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DW349_RS02790	COG3384	dioxygenase
DW349_RS02805	COG1175	transmembrane transport
DW349_RS02815	COG0246	Mannitol dehydrogenase
DW349_RS02855	COG0840	transmembrane signaling receptor activity
DW349_RS02870	COG1230	cation diffusion facilitator family transporter
DW349_RS02875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DW349_RS02880	COG0306	phosphate transporter
DW349_RS02885	COG1392	Phosphate transport regulator
DW349_RS02890	COG1607	acyl-coa hydrolase
DW349_RS02900	COG0573	inorganic phosphate transmembrane transporter activity
DW349_RS02910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DW349_RS02915	COG0704	Plays a role in the regulation of phosphate uptake
DW349_RS02955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DW349_RS02960	COG1773	rubredoxin
DW349_RS02980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DW349_RS02990	COG1166	arginine decarboxylase activity
DW349_RS03000	COG1560	Kdo2-lipid A biosynthetic process
DW349_RS03005	COG1252	NADH dehydrogenase
DW349_RS03015	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DW349_RS03020	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DW349_RS03065	COG0641	radical SAM
DW349_RS03170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DW349_RS03175	COG3151	Protein conserved in bacteria
DW349_RS03180	COG0494	nUDIX hydrolase
DW349_RS03185	COG1538	Outer membrane efflux protein
DW349_RS03200	COG0004	ammonium transporteR
DW349_RS03205	COG2115	Belongs to the xylose isomerase family
DW349_RS03215	COG0477	Major facilitator Superfamily
DW349_RS03220	COG1309	transcriptional regulator
DW349_RS03225	COG1846	Transcriptional regulator
DW349_RS03225	COG1940	carbohydrate kinase activity
DW349_RS03240	COG0395	ABC-type sugar transport system, permease component
DW349_RS03245	COG3507	Belongs to the glycosyl hydrolase 43 family
DW349_RS03250	COG4213	ABC transporter substrate-binding protein
DW349_RS03255	COG4214	carbohydrate transport
DW349_RS03265	COG0248	Ppx GppA phosphatase
DW349_RS03270	COG3386	PFAM SMP-30 Gluconolaconase
DW349_RS03275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DW349_RS03290	COG1304	FMN binding
DW349_RS03320	COG2199	diguanylate cyclase activity
DW349_RS03330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DW349_RS03340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DW349_RS03355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DW349_RS03360	COG2205	protein histidine kinase activity
DW349_RS03370	COG1162	GTPase activity
DW349_RS03385	COG1519	Transferase
DW349_RS03390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DW349_RS03405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DW349_RS03405	COG2813	Specifically methylates the guanine in position
DW349_RS03410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DW349_RS03435	COG3437	response regulator, receiver
DW349_RS03435	COG0784	Response regulator, receiver
DW349_RS03445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DW349_RS03450	COG2186	Transcriptional regulator
DW349_RS03495	COG0071	Belongs to the small heat shock protein (HSP20) family
DW349_RS03515	COG1129	ABC transporter
DW349_RS03520	COG1172	Belongs to the binding-protein-dependent transport system permease family
DW349_RS03530	COG0667	Aldo Keto reductase
DW349_RS03535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DW349_RS03545	COG1070	Carbohydrate kinase
DW349_RS03550	COG1454	alcohol dehydrogenase
DW349_RS03560	COG1942	4-Oxalocrotonate Tautomerase
DW349_RS03565	COG1414	Transcriptional regulator
DW349_RS03585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DW349_RS03590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW349_RS03595	COG4558	Periplasmic binding protein
DW349_RS03600	COG3720	iron ion transport
DW349_RS03605	COG4206	TonB-dependent receptor
DW349_RS03615	COG1120	ATPase activity
DW349_RS03620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW349_RS03625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW349_RS03675	COG2814	Major facilitator Superfamily
DW349_RS03680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW349_RS03685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW349_RS03690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DW349_RS03710	COG0477	Major facilitator Superfamily
DW349_RS03720	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DW349_RS03750	COG2205	protein histidine kinase activity
DW349_RS03755	COG3217	Mosc domain protein beta barrel domain protein
DW349_RS03755	COG0633	Ferredoxin
DW349_RS03760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DW349_RS03765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DW349_RS03785	COG2119	membrane
DW349_RS03800	COG2358	TRAP transporter, solute receptor (TAXI family
DW349_RS03805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DW349_RS03810	COG0358	DNA primase activity
DW349_RS03820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DW349_RS03825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DW349_RS03830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DW349_RS03840	COG0110	maltose O-acetyltransferase activity
DW349_RS03850	COG4181	ATPase activity
DW349_RS03855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DW349_RS03860	COG0450	alkyl hydroperoxide reductase
DW349_RS03875	COG1162	GTPase activity
DW349_RS03880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DW349_RS03890	COG3118	belongs to the thioredoxin family
DW349_RS03895	COG1960	acyl-CoA dehydrogenase activity
DW349_RS03905	COG0011	TIGRFAM Protein of
DW349_RS03910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DW349_RS03925	COG2133	pyrroloquinoline quinone binding
DW349_RS03925	COG5183	chlorophyll binding
DW349_RS03950	COG2165	general secretion pathway protein
DW349_RS03955	COG0166	Belongs to the GPI family
DW349_RS03960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DW349_RS03970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DW349_RS03980	COG0617	tRNA 3'-terminal CCA addition
DW349_RS03985	COG2204	response regulator
DW349_RS03990	COG5002	protein histidine kinase activity
DW349_RS03995	COG0784	Response regulator, receiver
DW349_RS03995	COG3437	response regulator, receiver
DW349_RS04015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DW349_RS04020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DW349_RS04025	COG0436	Aminotransferase
DW349_RS04035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DW349_RS04040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW349_RS04055	COG1509	lysine 2,3-aminomutase activity
DW349_RS04060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DW349_RS04070	COG4597	amino acid ABC transporter
DW349_RS04075	COG0765	amino acid transport
DW349_RS04080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DW349_RS04090	COG1126	abc transporter atp-binding protein
DW349_RS04095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DW349_RS04100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DW349_RS04110	COG0688	phosphatidylethanolamine metabolic process
DW349_RS04125	COG2351	hydroxyisourate hydrolase activity
DW349_RS04140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DW349_RS04150	COG0477	Major facilitator Superfamily
DW349_RS04170	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DW349_RS04180	COG0492	ferredoxin-NADP+ reductase activity
DW349_RS04190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DW349_RS04195	COG4149	molybdate abc transporter
DW349_RS04205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DW349_RS04215	COG1183	phosphatidylcholine synthase activity
DW349_RS04220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DW349_RS04245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DW349_RS04250	COG2363	Small membrane protein
DW349_RS04260	COG2177	Part of the ABC transporter FtsEX involved in
DW349_RS04265	COG2884	Cell division ATP-binding protein ftsE
DW349_RS04270	COG0552	protein localization to endoplasmic reticulum
DW349_RS04280	COG0742	ribosomal rna small subunit methyltransferase
DW349_RS04290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DW349_RS04300	COG0516	GMP reductase activity
DW349_RS04320	COG0189	ligase activity
DW349_RS04325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DW349_RS04330	COG4136	ATPase activity
DW349_RS04335	COG4135	transport system, permease component
DW349_RS04340	COG4134	Bacterial extracellular solute-binding protein
DW349_RS04345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DW349_RS04360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DW349_RS04370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DW349_RS04375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DW349_RS04380	COG0149	triose-phosphate isomerase activity
DW349_RS04400	COG0779	Required for maturation of 30S ribosomal subunits
DW349_RS04405	COG2251	uridine kinase activity
DW349_RS04405	COG0195	Participates in both transcription termination and antitermination
DW349_RS04410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DW349_RS04415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DW349_RS04420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DW349_RS04425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DW349_RS04430	COG1185	polyribonucleotide nucleotidyltransferase activity
DW349_RS04450	COG1131	(ABC) transporter
DW349_RS04465	COG0385	Bile acid
DW349_RS04480	COG1459	type II secretion system
DW349_RS04485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DW349_RS04500	COG3409	Peptidoglycan-binding domain 1 protein
DW349_RS04500	COG3267	Type II secretory pathway component ExeA
DW349_RS04530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DW349_RS04535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DW349_RS04540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DW349_RS04550	COG0395	ABC-type sugar transport system, permease component
DW349_RS04555	COG1175	transmembrane transport
DW349_RS04560	COG1653	transport
DW349_RS04565	COG1653	transport
DW349_RS04580	COG0590	tRNA wobble adenosine to inosine editing
DW349_RS04600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DW349_RS04605	COG0142	geranyltranstransferase activity
DW349_RS04610	COG1722	exodeoxyribonuclease VII activity
DW349_RS04615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DW349_RS04620	COG1360	Flagellar Motor Protein
DW349_RS04630	COG2823	Periplasmic or secreted lipoprotein
DW349_RS04635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DW349_RS04640	COG0792	nuclease activity
DW349_RS04645	COG3107	peptidoglycan biosynthetic process
DW349_RS04665	COG0275	rRNA processing
DW349_RS04670	COG3116	cell division
DW349_RS04680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DW349_RS04685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DW349_RS04690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DW349_RS04695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DW349_RS04700	COG0772	Belongs to the SEDS family
DW349_RS04705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DW349_RS04710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DW349_RS04715	COG1181	Belongs to the D-alanine--D-alanine ligase family
DW349_RS04720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DW349_RS04730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DW349_RS04740	COG0739	heme binding
DW349_RS04745	COG0653	protein targeting
DW349_RS04750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DW349_RS04755	COG0494	nUDIX hydrolase
DW349_RS04770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DW349_RS04785	COG4969	Belongs to the N-Me-Phe pilin family
DW349_RS04800	COG0492	ferredoxin-NADP+ reductase activity
DW349_RS04805	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DW349_RS04810	COG2894	cell division
DW349_RS04815	COG0850	regulation of cytokinetic process
DW349_RS04835	COG0586	Pfam SNARE associated Golgi protein
DW349_RS04840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DW349_RS04845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DW349_RS04855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DW349_RS04860	COG0768	penicillin binding
DW349_RS04865	COG0772	Belongs to the SEDS family
DW349_RS04870	COG2951	lytic endotransglycosylase activity
DW349_RS04875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DW349_RS04880	COG1686	Belongs to the peptidase S11 family
DW349_RS04890	COG0321	lipoyl(octanoyl) transferase activity
DW349_RS04895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DW349_RS04905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DW349_RS04910	COG1309	transcriptional regulator
DW349_RS04925	COG0788	formyltetrahydrofolate deformylase activity
DW349_RS04935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DW349_RS04940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DW349_RS04940	COG0047	phosphoribosylformylglycinamidine synthase activity
DW349_RS04950	COG0596	Alpha beta hydrolase
DW349_RS04965	COG0354	folic acid binding
DW349_RS04970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DW349_RS05005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DW349_RS05010	COG0481	GTPase activity
DW349_RS05015	COG0681	Belongs to the peptidase S26 family
DW349_RS05025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DW349_RS05035	COG0736	holo-[acyl-carrier-protein] synthase activity
DW349_RS05050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DW349_RS05055	COG3956	TIGRFAM MazG family protein
DW349_RS05065	COG2814	Major facilitator Superfamily
DW349_RS05090	COG0142	geranyltranstransferase activity
DW349_RS05095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DW349_RS05100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DW349_RS05105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DW349_RS05110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DW349_RS05115	COG2818	Glycosylase
DW349_RS05130	COG0114	fumarate hydratase activity
DW349_RS05135	COG4535	Mg2 and Co2 transporter CorC
DW349_RS05140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DW349_RS05145	COG1702	phosphate starvation-inducible protein PhoH
DW349_RS05150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DW349_RS05160	COG2814	Major facilitator Superfamily
DW349_RS05170	COG0307	riboflavin synthase, alpha
DW349_RS05180	COG0277	FAD linked oxidase domain protein
DW349_RS05185	COG3806	Anti-sigma factor
DW349_RS05190	COG1595	DNA-templated transcription, initiation
DW349_RS05195	COG3028	Belongs to the UPF0307 family
DW349_RS05200	COG2239	Acts as a magnesium transporter
DW349_RS05205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DW349_RS05210	COG1660	Displays ATPase and GTPase activities
DW349_RS05225	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DW349_RS05230	COG1137	ATPase activity
DW349_RS05260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DW349_RS05265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DW349_RS05275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DW349_RS05280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DW349_RS05285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DW349_RS05295	COG0175	sulfate reduction
DW349_RS05305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DW349_RS05315	COG1215	transferase activity, transferring glycosyl groups
DW349_RS05345	COG3250	beta-galactosidase activity
DW349_RS05360	COG0395	ABC-type sugar transport system, permease component
DW349_RS05365	COG1175	transmembrane transport
DW349_RS05375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DW349_RS05390	COG1131	(ABC) transporter
DW349_RS05395	COG0842	Transport permease protein
DW349_RS05400	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DW349_RS05400	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DW349_RS05415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DW349_RS05420	COG0390	transport system, permease component
DW349_RS05430	COG1733	regulation of RNA biosynthetic process
DW349_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS05455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DW349_RS05465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DW349_RS05505	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DW349_RS05510	COG0372	Belongs to the citrate synthase family
DW349_RS05515	COG2079	MmgE PrpD family protein
DW349_RS05535	COG0577	efflux transmembrane transporter activity
DW349_RS05540	COG1136	(ABC) transporter
DW349_RS05545	COG0730	response to heat
DW349_RS05550	COG1122	ATPase activity
DW349_RS05560	COG1268	BioY protein
DW349_RS05565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DW349_RS05565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DW349_RS05570	COG0509	glycine decarboxylation via glycine cleavage system
DW349_RS05580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DW349_RS05595	COG2171	N-acyltransferase activity
DW349_RS05600	COG1393	Belongs to the ArsC family
DW349_RS05605	COG0436	Aminotransferase
DW349_RS05610	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DW349_RS05615	COG0024	Methionine aminopeptidase
DW349_RS05620	COG0052	Belongs to the universal ribosomal protein uS2 family
DW349_RS05625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DW349_RS05630	COG0528	UMP kinase activity
DW349_RS05635	COG0233	cytoplasmic translational termination
DW349_RS05640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DW349_RS05660	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DW349_RS05670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW349_RS05675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DW349_RS05680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW349_RS05685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW349_RS05710	COG0037	tRNA processing
DW349_RS05720	COG0148	phosphopyruvate hydratase activity
DW349_RS05725	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DW349_RS05730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DW349_RS05735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DW349_RS05740	COG0585	pseudouridine synthase activity
DW349_RS05745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DW349_RS05765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DW349_RS05770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DW349_RS05775	COG1058	Belongs to the CinA family
DW349_RS05775	COG1546	Belongs to the CinA family
DW349_RS05780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DW349_RS05785	COG2137	regulation of response to DNA damage stimulus
DW349_RS05790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DW349_RS05795	COG0527	aspartate kinase activity
DW349_RS05800	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DW349_RS05835	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DW349_RS05870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DW349_RS05870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DW349_RS05900	COG1902	pentaerythritol trinitrate reductase activity
DW349_RS05900	COG0446	pyridine nucleotide-disulphide oxidoreductase
DW349_RS05905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DW349_RS05915	COG0300	oxidoreductase activity
DW349_RS05920	COG0123	including yeast histone deacetylase and acetoin utilization protein
DW349_RS05925	COG0045	succinate-CoA ligase (ADP-forming) activity
DW349_RS05925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DW349_RS05925	COG1042	CoA-binding domain protein
DW349_RS05930	COG2816	NAD+ diphosphatase activity
DW349_RS05940	COG0037	tRNA processing
DW349_RS05965	COG2217	Heavy metal translocating P-type atpase
DW349_RS05975	COG0348	domain, Protein
DW349_RS05980	COG2010	Cytochrome c
DW349_RS05995	COG3278	Belongs to the heme-copper respiratory oxidase family
DW349_RS06000	COG1254	Belongs to the acylphosphatase family
DW349_RS06005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DW349_RS06010	COG0217	transcriptional regulatory protein
DW349_RS06015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DW349_RS06025	COG2255	four-way junction helicase activity
DW349_RS06045	COG0823	Involved in the tonB-independent uptake of proteins
DW349_RS06050	COG2885	chlorophyll binding
DW349_RS06055	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DW349_RS06060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DW349_RS06075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DW349_RS06095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DW349_RS06110	COG1234	tRNA 3'-trailer cleavage
DW349_RS06115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DW349_RS06125	COG1309	transcriptional regulator
DW349_RS06130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DW349_RS06130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DW349_RS06150	COG0545	Peptidyl-prolyl cis-trans isomerase
DW349_RS06175	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DW349_RS06180	COG0425	Belongs to the sulfur carrier protein TusA family
DW349_RS06185	COG0534	Mate efflux family protein
DW349_RS06190	COG3101	peptidyl-lysine hydroxylation
DW349_RS06195	COG3300	MHYT domain
DW349_RS06195	COG5001	Diguanylate cyclase
DW349_RS06215	COG0346	lactoylglutathione lyase activity
DW349_RS06230	COG1335	isochorismatase
DW349_RS06255	COG0494	nUDIX hydrolase
DW349_RS06260	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DW349_RS06270	COG0625	glutathione transferase activity
DW349_RS06290	COG0583	DNA-binding transcription factor activity
DW349_RS06300	COG0500	methyltransferase
DW349_RS06310	COG1942	4-Oxalocrotonate Tautomerase
DW349_RS06350	COG0436	Aminotransferase
DW349_RS06355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DW349_RS06380	COG1012	belongs to the aldehyde dehydrogenase family
DW349_RS06400	COG4175	Glycine betaine
DW349_RS06405	COG1846	Transcriptional regulator
DW349_RS06430	COG0840	transmembrane signaling receptor activity
DW349_RS06435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DW349_RS06445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DW349_RS06450	COG1077	Cell shape determining protein MreB Mrl
DW349_RS06455	COG1792	Involved in formation and maintenance of cell shape
DW349_RS06460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DW349_RS06470	COG1530	ribonuclease E activity
DW349_RS06480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DW349_RS06495	COG1280	lysine exporter protein (LysE YggA)
DW349_RS06500	COG2962	Rard protein
DW349_RS06505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DW349_RS06510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DW349_RS06535	COG4208	sulfate ABC transporter
DW349_RS06540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DW349_RS06545	COG0366	Alpha amylase catalytic
DW349_RS06555	COG0454	-acetyltransferase
DW349_RS06595	COG3634	alkyl hydroperoxide reductase activity
DW349_RS06615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DW349_RS06660	COG0402	S-adenosylhomocysteine deaminase activity
DW349_RS06665	COG1309	transcriptional regulator
DW349_RS06680	COG1619	proteins homologs of microcin C7 resistance protein MccF
DW349_RS06700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DW349_RS06715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DW349_RS06725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DW349_RS06730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DW349_RS06735	COG2890	protein-(glutamine-N5) methyltransferase activity
DW349_RS06745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DW349_RS06750	COG0840	transmembrane signaling receptor activity
DW349_RS06760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DW349_RS06770	COG0683	leucine binding
DW349_RS06820	COG1136	(ABC) transporter
DW349_RS06820	COG0577	efflux transmembrane transporter activity
DW349_RS06830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DW349_RS06840	COG0372	Belongs to the citrate synthase family
DW349_RS06875	COG0668	transmembrane transport
DW349_RS06895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DW349_RS06925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DW349_RS06930	COG0288	reversible hydration of carbon dioxide
DW349_RS07015	COG0525	valine-tRNA ligase activity
DW349_RS07040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DW349_RS07050	COG0640	Transcriptional regulator
DW349_RS07060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DW349_RS07065	COG1643	Atp-dependent helicase
DW349_RS07075	COG0252	asparaginase activity
DW349_RS07080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DW349_RS07090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DW349_RS07110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DW349_RS07115	COG0745	RESPONSE REGULATOR receiver
DW349_RS07140	COG1214	PFAM Peptidase M22, glycoprotease
DW349_RS07145	COG1968	undecaprenyl-diphosphatase activity
DW349_RS07150	COG0742	ribosomal rna small subunit methyltransferase
DW349_RS07160	COG2900	Belongs to the SlyX family
DW349_RS07180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DW349_RS07200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DW349_RS07205	COG0277	FAD linked oxidase domain protein
DW349_RS07205	COG0247	lactate metabolic process
DW349_RS07210	COG0517	IMP dehydrogenase activity
DW349_RS07210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DW349_RS07210	COG0617	tRNA 3'-terminal CCA addition
DW349_RS07220	COG0442	prolyl-tRNA aminoacylation
DW349_RS07225	COG0346	lactoylglutathione lyase activity
DW349_RS07255	COG0625	glutathione transferase activity
DW349_RS07265	COG4536	flavin adenine dinucleotide binding
DW349_RS07275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DW349_RS07280	COG0228	four-way junction DNA binding
DW349_RS07285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DW349_RS07295	COG0335	large ribosomal subunit rRNA binding
DW349_RS07320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DW349_RS07330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DW349_RS07365	COG3530	Putative quorum-sensing-regulated virulence factor
DW349_RS07380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DW349_RS07395	COG0564	pseudouridine synthase activity
DW349_RS07400	COG1448	Aminotransferase
DW349_RS07405	COG0556	nucleotide-excision repair
DW349_RS07475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DW349_RS07480	COG0835	chemotaxis
DW349_RS07480	COG0784	Response regulator, receiver
DW349_RS07485	COG0840	transmembrane signaling receptor activity
DW349_RS07520	COG1132	(ABC) transporter
DW349_RS07535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DW349_RS07545	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DW349_RS07550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DW349_RS07575	COG0667	Aldo Keto reductase
DW349_RS07585	COG4106	trans-aconitate 2-methyltransferase activity
DW349_RS07590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DW349_RS07600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DW349_RS07605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DW349_RS07615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DW349_RS07635	COG5265	(ABC) transporter
DW349_RS07650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DW349_RS07655	COG4221	oxidoreductase activity
DW349_RS07665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DW349_RS07670	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DW349_RS07675	COG4597	amino acid ABC transporter
DW349_RS07680	COG0765	amino acid transport
DW349_RS07700	COG4176	ABC-type proline glycine betaine transport system permease component
DW349_RS07715	COG0183	Belongs to the thiolase family
DW349_RS07725	COG0583	DNA-binding transcription factor activity
DW349_RS07775	COG0784	Response regulator, receiver
DW349_RS07775	COG0835	chemotaxis
DW349_RS07785	COG1815	bacterial-type flagellum-dependent cell motility
DW349_RS07800	COG1749	Flagellar hook protein flgE
DW349_RS07815	COG4786	Flagellar basal body rod
DW349_RS07820	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DW349_RS07825	COG1706	bacterial-type flagellum-dependent cell motility
DW349_RS07850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DW349_RS07855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DW349_RS07865	COG2089	acid synthase
DW349_RS07885	COG1083	cytidylyl-transferase
DW349_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS07915	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DW349_RS07920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DW349_RS07950	COG1677	Flagellar hook-basal body complex protein FliE
DW349_RS07960	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DW349_RS08025	COG1987	bacterial-type flagellum assembly
DW349_RS08070	COG0643	Histidine kinase
DW349_RS08070	COG2198	Histidine kinase
DW349_RS08070	COG0784	Response regulator, receiver
DW349_RS08075	COG2201	protein-glutamate methylesterase activity
DW349_RS08080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DW349_RS08090	COG1192	Involved in chromosome partitioning
DW349_RS08100	COG0835	chemotaxis
DW349_RS08110	COG2853	Lipoprotein
DW349_RS08120	COG0745	RESPONSE REGULATOR receiver
DW349_RS08130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DW349_RS08160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DW349_RS08175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DW349_RS08200	COG1393	Belongs to the ArsC family
DW349_RS08215	COG4232	protein-disulfide reductase activity
DW349_RS08225	COG0271	Belongs to the BolA IbaG family
DW349_RS08250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DW349_RS08255	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DW349_RS08260	COG1805	sodium ion transport
DW349_RS08270	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DW349_RS08275	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DW349_RS08280	COG2871	sodium ion transport
DW349_RS08285	COG1477	protein flavinylation
DW349_RS08295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DW349_RS08305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DW349_RS08310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DW349_RS08315	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DW349_RS08330	COG0616	signal peptide processing
DW349_RS08335	COG0741	lytic transglycosylase activity
DW349_RS08335	COG1388	LysM domain
DW349_RS08340	COG2226	methyltransferase
DW349_RS08345	COG0328	RNA-DNA hybrid ribonuclease activity
DW349_RS08350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DW349_RS08355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DW349_RS08365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DW349_RS08375	COG0730	response to heat
DW349_RS08390	COG0560	Phosphoserine phosphatase
DW349_RS08400	COG1716	ATPase activity
DW349_RS08405	COG0515	serine threonine protein kinase
DW349_RS08405	COG2815	serine threonine protein kinase
DW349_RS08410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DW349_RS08445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DW349_RS08470	COG2902	Dehydrogenase
DW349_RS08480	COG0167	dihydroorotate dehydrogenase activity
DW349_RS08485	COG3130	regulation of translation
DW349_RS08490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DW349_RS08490	COG0116	Belongs to the methyltransferase superfamily
DW349_RS08495	COG2813	Specifically methylates the guanine in position
DW349_RS08505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DW349_RS08515	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW349_RS08525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DW349_RS08545	COG0544	peptidyl-prolyl cis-trans isomerase activity
DW349_RS08550	COG0740	serine-type endopeptidase activity
DW349_RS08555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DW349_RS08560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DW349_RS08570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DW349_RS08580	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DW349_RS08585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DW349_RS08590	COG1199	ATP-dependent helicase activity
DW349_RS08595	COG2957	Belongs to the agmatine deiminase family
DW349_RS08605	COG4591	ABC-type transport system involved in lipoprotein release permease component
DW349_RS08615	COG0658	competence protein
DW349_RS08615	COG2333	competence protein COMEC
DW349_RS08620	COG0811	peptide transport
DW349_RS08625	COG0848	biopolymer transport protein
DW349_RS08630	COG1663	tetraacyldisaccharide 4'-kinase activity
DW349_RS08635	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DW349_RS08640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DW349_RS08655	COG1530	ribonuclease E activity
DW349_RS08670	COG0424	maF-like protein
DW349_RS08675	COG1399	metal-binding, possibly nucleic acid-binding protein
DW349_RS08680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DW349_RS08700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DW349_RS08705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DW349_RS08715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DW349_RS08720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DW349_RS08760	COG0784	Response regulator, receiver
DW349_RS08760	COG5002	protein histidine kinase activity
DW349_RS08760	COG2205	protein histidine kinase activity
DW349_RS08770	COG1459	type II secretion system
DW349_RS08825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DW349_RS08830	COG4585	Histidine kinase
DW349_RS08835	COG2197	response regulator
DW349_RS08855	COG0798	PFAM Bile acid sodium symporter
DW349_RS08860	COG0431	NADPH-dependent FMN reductase
DW349_RS08870	COG0640	Transcriptional regulator
DW349_RS08890	COG0587	DNA-directed DNA polymerase activity
DW349_RS08905	COG1477	protein flavinylation
DW349_RS08920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DW349_RS08950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DW349_RS08985	COG0708	Exodeoxyribonuclease III
DW349_RS09015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DW349_RS09020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DW349_RS09030	COG0670	Belongs to the BI1 family
DW349_RS09035	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DW349_RS09050	COG2920	part of a sulfur-relay system
DW349_RS09055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DW349_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS09070	COG1648	precorrin-2 dehydrogenase activity
DW349_RS09070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DW349_RS09075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DW349_RS09080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DW349_RS09085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DW349_RS09095	COG1674	ftsk spoiiie
DW349_RS09100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DW349_RS09105	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DW349_RS09110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DW349_RS09115	COG0542	response to heat
DW349_RS09120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DW349_RS09125	COG1278	Cold shock
DW349_RS09135	COG1187	pseudouridine synthase activity
DW349_RS09140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DW349_RS09150	COG0482	sulfurtransferase activity
DW349_RS09155	COG2915	High frequency lysogenization protein hflD homolog
DW349_RS09165	COG2850	peptidyl-arginine hydroxylation
DW349_RS09185	COG0326	Molecular chaperone. Has ATPase activity
DW349_RS09220	COG0045	succinate-CoA ligase (ADP-forming) activity
DW349_RS09240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DW349_RS09245	COG1053	succinate dehydrogenase
DW349_RS09255	COG2009	succinate dehydrogenase
DW349_RS09285	COG0024	Methionine aminopeptidase
DW349_RS09320	COG3739	integral membrane protein
DW349_RS09325	COG0456	acetyltransferase
DW349_RS09330	COG0183	Belongs to the thiolase family
DW349_RS09335	COG1250	3-hydroxyacyl-CoA dehydrogenase
DW349_RS09335	COG1024	Enoyl-CoA hydratase
DW349_RS09345	COG0488	(ABC) transporter
DW349_RS09350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW349_RS09360	COG0741	lytic transglycosylase activity
DW349_RS09370	COG0835	chemotaxis
DW349_RS09370	COG0784	Response regulator, receiver
DW349_RS09390	COG0583	DNA-binding transcription factor activity
DW349_RS09400	COG3022	response to hydroperoxide
DW349_RS09405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DW349_RS09410	COG0667	Aldo Keto reductase
DW349_RS09430	COG1752	Esterase of the alpha-beta hydrolase superfamily
DW349_RS09455	COG0308	aminopeptidase N
DW349_RS09465	COG3139	Protein of unknown function (DUF1315)
DW349_RS09470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DW349_RS09480	COG0676	glucose-6-phosphate 1-epimerase activity
DW349_RS09500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DW349_RS09500	COG0316	Belongs to the HesB IscA family
DW349_RS09520	COG1294	oxidase, subunit
DW349_RS09525	COG4890	Cyd operon protein YbgT
DW349_RS09535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DW349_RS09540	COG1295	ribonuclease BN
DW349_RS09560	COG0300	oxidoreductase activity
DW349_RS09580	COG3639	organic phosphonate transmembrane transporter activity
DW349_RS09615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DW349_RS09620	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS09625	COG2199	diguanylate cyclase activity
DW349_RS09625	COG2203	Gaf domain
DW349_RS09630	COG1335	isochorismatase
DW349_RS09660	COG1286	toxin biosynthetic process
DW349_RS09670	COG0285	dihydrofolate synthase activity
DW349_RS09675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DW349_RS09680	COG0159	tryptophan synthase activity
DW349_RS09690	COG0135	phosphoribosylanthranilate isomerase activity
DW349_RS09710	COG0473	3-isopropylmalate dehydrogenase activity
DW349_RS09715	COG0066	3-isopropylmalate dehydratase activity
DW349_RS09720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DW349_RS09735	COG2974	May be involved in recombination
DW349_RS09755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DW349_RS09760	COG3115	cell septum assembly
DW349_RS09760	COG3115	cell septum assembly
DW349_RS09780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DW349_RS09790	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DW349_RS09830	COG1643	Atp-dependent helicase
DW349_RS09835	COG0318	PFAM AMP-dependent synthetase and ligase
DW349_RS09855	COG2983	Belongs to the UPF0260 family
DW349_RS09860	COG3100	YcgL domain-containing protein
DW349_RS09875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DW349_RS09880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DW349_RS09915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DW349_RS09940	COG0602	queuosine metabolic process
DW349_RS09950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DW349_RS09980	COG0477	Major facilitator Superfamily
DW349_RS09985	COG1309	transcriptional regulator
DW349_RS10000	COG0776	regulation of translation
DW349_RS10005	COG0072	phenylalanine-tRNA ligase activity
DW349_RS10010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DW349_RS10015	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DW349_RS10020	COG0540	Belongs to the ATCase OTCase family
DW349_RS10025	COG1555	photosystem II stabilization
DW349_RS10040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DW349_RS10060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DW349_RS10065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DW349_RS10070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DW349_RS10080	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DW349_RS10090	COG0402	S-adenosylhomocysteine deaminase activity
DW349_RS10095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DW349_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS10110	COG3706	GGDEF domain
DW349_RS10120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DW349_RS10130	COG0009	L-threonylcarbamoyladenylate synthase
DW349_RS10140	COG2350	Protein conserved in bacteria
DW349_RS10150	COG0006	proline dipeptidase activity
DW349_RS10160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DW349_RS10160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DW349_RS10175	COG0215	cysteine-tRNA ligase activity
DW349_RS10180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DW349_RS10185	COG2835	tetraacyldisaccharide 4'-kinase activity
DW349_RS10190	COG0668	transmembrane transport
DW349_RS10215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DW349_RS10240	COG1132	(ABC) transporter
DW349_RS10265	COG3562	capsule polysaccharide
DW349_RS10275	COG0438	transferase activity, transferring glycosyl groups
DW349_RS10290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DW349_RS10315	COG0438	transferase activity, transferring glycosyl groups
DW349_RS10320	COG2801	Transposase and inactivated derivatives
DW349_RS10325	COG5039	Polysaccharide pyruvyl transferase
DW349_RS10330	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DW349_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS10355	COG1218	3'(2'),5'-bisphosphate nucleotidase
DW349_RS10360	COG3273	potassium ion transport
DW349_RS10360	COG0471	metal ion transport
DW349_RS10365	COG0529	Catalyzes the synthesis of activated sulfate
DW349_RS10375	COG0489	protein tyrosine kinase activity
DW349_RS10385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DW349_RS10385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DW349_RS10395	COG4657	Part of a membrane complex involved in electron transport
DW349_RS10400	COG2878	Part of a membrane complex involved in electron transport
DW349_RS10410	COG4658	electron transport chain
DW349_RS10420	COG4660	Part of a membrane complex involved in electron transport
DW349_RS10425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DW349_RS10435	COG2932	Transcriptional regulator
DW349_RS10460	COG1012	belongs to the aldehyde dehydrogenase family
DW349_RS10465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DW349_RS10470	COG0563	adenylate kinase activity
DW349_RS10485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DW349_RS10505	COG0625	glutathione transferase activity
DW349_RS10515	COG3031	protein transport across the cell outer membrane
DW349_RS10525	COG0459	protein refolding
DW349_RS10530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DW349_RS10540	COG0517	IMP dehydrogenase activity
DW349_RS10545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DW349_RS10550	COG5002	protein histidine kinase activity
DW349_RS10555	COG2096	Adenosyltransferase
DW349_RS10565	COG0509	glycine decarboxylation via glycine cleavage system
DW349_RS10570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DW349_RS10570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DW349_RS10585	COG1176	ABC-type spermidine putrescine transport system, permease component I
DW349_RS10595	COG3842	ATPase activity
DW349_RS10600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DW349_RS10605	COG1132	(ABC) transporter
DW349_RS10615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DW349_RS10620	COG0686	Belongs to the AlaDH PNT family
DW349_RS10625	COG1609	Transcriptional regulator
DW349_RS10635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DW349_RS10640	COG2017	converts alpha-aldose to the beta-anomer
DW349_RS10645	COG1054	Belongs to the UPF0176 family
DW349_RS10660	COG1160	GTP binding
DW349_RS10670	COG2169	Transcriptional regulator
DW349_RS10670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DW349_RS10675	COG1011	Hydrolase
DW349_RS10690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DW349_RS10695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DW349_RS10700	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DW349_RS10705	COG0679	Auxin Efflux Carrier
DW349_RS10715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DW349_RS10720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DW349_RS10740	COG2146	nitrite reductase [NAD(P)H] activity
DW349_RS10740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DW349_RS10745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DW349_RS10745	COG2146	nitrite reductase [NAD(P)H] activity
DW349_RS10755	COG1012	belongs to the aldehyde dehydrogenase family
DW349_RS10760	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DW349_RS10765	COG1473	amidohydrolase
DW349_RS10770	COG0730	response to heat
DW349_RS10820	COG0673	inositol 2-dehydrogenase activity
DW349_RS10830	COG2723	6-phospho-beta-galactosidase activity
DW349_RS10840	COG1609	Transcriptional regulator
DW349_RS10860	COG1803	Methylglyoxal synthase
DW349_RS10875	COG1794	racemase activity, acting on amino acids and derivatives
DW349_RS10880	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DW349_RS10895	COG0384	phenazine biosynthesis protein PhzF
DW349_RS10905	COG0583	DNA-binding transcription factor activity
DW349_RS10920	COG1764	response to oxidative stress
DW349_RS10945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DW349_RS10950	COG0826	peptidase U32
DW349_RS10955	COG2204	response regulator
DW349_RS10960	COG4191	Histidine kinase
DW349_RS10975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DW349_RS10980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DW349_RS10985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DW349_RS10990	COG0193	aminoacyl-tRNA hydrolase activity
DW349_RS11020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DW349_RS11035	COG2186	Transcriptional regulator
DW349_RS11040	COG4608	Belongs to the ABC transporter superfamily
DW349_RS11045	COG0444	Belongs to the ABC transporter superfamily
DW349_RS11055	COG0747	negative chemotaxis
DW349_RS11070	COG1363	Peptidase, m42
DW349_RS11085	COG1902	pentaerythritol trinitrate reductase activity
DW349_RS11095	COG1741	Belongs to the pirin family
DW349_RS11115	COG1120	ATPase activity
DW349_RS11120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW349_RS11125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DW349_RS11130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DW349_RS11140	COG1309	transcriptional regulator
DW349_RS11145	COG1609	Transcriptional regulator
DW349_RS11150	COG0584	glycerophosphoryl diester phosphodiesterase
DW349_RS11160	COG3833	ABC-type maltose transport systems, permease component
DW349_RS11190	COG2925	Exonuclease
DW349_RS11195	COG1396	sequence-specific DNA binding
DW349_RS11200	COG3135	benzoate transporter
DW349_RS11205	COG1024	Enoyl-CoA hydratase
DW349_RS11230	COG0537	adenosine 5'-monophosphoramidase activity
DW349_RS11235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DW349_RS11255	COG1360	Flagellar Motor Protein
DW349_RS11260	COG0204	Acyl-transferase
DW349_RS11270	COG0314	molybdopterin synthase activity
DW349_RS11275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DW349_RS11280	COG0315	cyclic pyranopterin monophosphate synthase activity
DW349_RS11285	COG0521	Mo-molybdopterin cofactor biosynthetic process
DW349_RS11290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DW349_RS11295	COG2719	SpoVR family
DW349_RS11300	COG2718	Belongs to the UPF0229 family
DW349_RS11305	COG2766	serine protein kinase
DW349_RS11310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DW349_RS11315	COG0604	alcohol dehydrogenase
DW349_RS11320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DW349_RS11325	COG2252	PERMEase
DW349_RS11330	COG0579	oxidoreductase
DW349_RS11335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DW349_RS11340	COG0305	Participates in initiation and elongation during chromosome replication
DW349_RS11355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DW349_RS11360	COG0360	Binds together with S18 to 16S ribosomal RNA
DW349_RS11380	COG0488	(ABC) transporter
DW349_RS11415	COG1215	transferase activity, transferring glycosyl groups
DW349_RS11420	COG3769	mannosylglycerate metabolic process
DW349_RS11435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DW349_RS11460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DW349_RS11465	COG0297	glycogen (starch) synthase activity
DW349_RS11475	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
DW349_RS11535	COG0625	glutathione transferase activity
DW349_RS11555	COG0840	transmembrane signaling receptor activity
DW349_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS11575	COG0625	glutathione transferase activity
DW349_RS11580	COG0583	DNA-binding transcription factor activity
DW349_RS11605	COG1160	GTP binding
DW349_RS11615	COG2976	Protein conserved in bacteria
DW349_RS11620	COG0124	histidyl-tRNA synthetase
DW349_RS11625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DW349_RS11645	COG2166	iron-sulfur cluster assembly
DW349_RS11650	COG2151	metal-sulfur cluster biosynthetic enzyme
DW349_RS11655	COG0316	Belongs to the HesB IscA family
DW349_RS11660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DW349_RS11665	COG0719	Fe-S assembly protein
DW349_RS11670	COG0396	ATPase activity
DW349_RS11675	COG0719	Fe-S assembly protein
DW349_RS11720	COG0300	oxidoreductase activity
DW349_RS11725	COG1309	transcriptional regulator
DW349_RS11750	COG2193	ferroxidase activity
DW349_RS11755	COG2193	ferroxidase activity
DW349_RS11760	COG2072	flavoprotein involved in K transport
DW349_RS11770	COG2144	transferase activity, transferring acyl groups
DW349_RS11795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DW349_RS11820	COG0583	DNA-binding transcription factor activity
DW349_RS11835	COG1620	l-lactate permease
DW349_RS11840	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DW349_RS11855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DW349_RS11860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DW349_RS11885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DW349_RS11885	COG0316	Belongs to the HesB IscA family
DW349_RS11890	COG1573	uracil-dna glycosylase
DW349_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS11905	COG3012	SEC-C Motif Domain Protein
DW349_RS11915	COG3098	single-species biofilm formation
DW349_RS11920	COG0784	Response regulator, receiver
DW349_RS11920	COG3437	response regulator, receiver
DW349_RS11925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DW349_RS11930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DW349_RS11940	COG1472	Belongs to the glycosyl hydrolase 3 family
DW349_RS11945	COG0625	glutathione transferase activity
DW349_RS11975	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DW349_RS11980	COG1178	ABC-type Fe3 transport system permease component
DW349_RS11985	COG4143	(ABC) transporter
DW349_RS12000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DW349_RS12010	COG1047	Peptidyl-prolyl cis-trans
DW349_RS12025	COG4172	Belongs to the ABC transporter superfamily
DW349_RS12030	COG4239	(ABC) transporter, permease
DW349_RS12035	COG4174	ABC transporter (Permease)
DW349_RS12040	COG4166	transmembrane transport
DW349_RS12045	COG2832	Protein of unknown function (DUF454)
DW349_RS12090	COG2207	Transcriptional regulator
DW349_RS12110	COG0450	alkyl hydroperoxide reductase
DW349_RS12120	COG3842	ATPase activity
DW349_RS12130	COG0800	Aldolase
DW349_RS12145	COG0363	glucosamine-6-phosphate deaminase activity
DW349_RS12155	COG1737	Transcriptional regulator
DW349_RS12160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DW349_RS12165	COG0469	pyruvate kinase activity
DW349_RS12175	COG0508	dehydrogenase complex catalyzes the overall conversion of
DW349_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS12190	COG2226	methyltransferase
DW349_RS12205	COG0589	response to stress
DW349_RS12210	COG0659	secondary active sulfate transmembrane transporter activity
DW349_RS12215	COG0393	Putative heavy-metal-binding
DW349_RS12230	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DW349_RS12235	COG1045	serine acetyltransferase
DW349_RS12240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DW349_RS12255	COG0604	alcohol dehydrogenase
DW349_RS12285	COG2204	response regulator
DW349_RS12295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW349_RS12300	COG1131	(ABC) transporter
DW349_RS12305	COG0842	Transport permease protein
DW349_RS12310	COG0842	Transport permease protein
DW349_RS12325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DW349_RS12340	COG0625	glutathione transferase activity
DW349_RS12380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DW349_RS12385	COG1280	lysine exporter protein (LysE YggA)
DW349_RS12390	COG0628	permease
DW349_RS12400	COG0446	pyridine nucleotide-disulphide oxidoreductase
DW349_RS12410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DW349_RS12425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DW349_RS12435	COG2224	Isocitrate lyase
DW349_RS12450	COG0765	amino acid transport
DW349_RS12455	COG0765	amino acid transport
DW349_RS12460	COG1126	abc transporter atp-binding protein
DW349_RS12465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DW349_RS12470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DW349_RS12475	COG1278	Cold shock
DW349_RS12480	COG2081	HI0933 family
DW349_RS12495	COG2207	Transcriptional regulator
DW349_RS12495	COG3708	Transcriptional regulator
DW349_RS12505	COG2814	Major facilitator Superfamily
DW349_RS12510	COG1104	cysteine desulfurase activity
DW349_RS12515	COG1522	sequence-specific DNA binding
DW349_RS12525	COG0840	transmembrane signaling receptor activity
DW349_RS12535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DW349_RS12560	COG2095	MarC family integral membrane protein
DW349_RS12565	COG1063	alcohol dehydrogenase
DW349_RS12570	COG0156	8-amino-7-oxononanoate synthase activity
DW349_RS12590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DW349_RS12600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DW349_RS12605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DW349_RS12615	COG3962	Belongs to the TPP enzyme family
DW349_RS12620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DW349_RS12625	COG0673	inositol 2-dehydrogenase activity
DW349_RS12635	COG1172	Belongs to the binding-protein-dependent transport system permease family
DW349_RS12650	COG0673	inositol 2-dehydrogenase activity
DW349_RS12655	COG3718	enzyme involved in inositol metabolism
DW349_RS12660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DW349_RS12660	COG4651	solute:proton antiporter activity
DW349_RS12680	COG3118	belongs to the thioredoxin family
DW349_RS12685	COG1025	Belongs to the peptidase M16 family
DW349_RS12700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DW349_RS12705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DW349_RS12715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DW349_RS12720	COG0557	exoribonuclease II activity
DW349_RS12725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DW349_RS12730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DW349_RS12735	COG0330	HflC and HflK could
DW349_RS12740	COG0330	HflC and HflK could
DW349_RS12745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DW349_RS12750	COG1923	regulation of RNA biosynthetic process
DW349_RS12755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DW349_RS12760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DW349_RS12765	COG0860	N-Acetylmuramoyl-L-alanine amidase
DW349_RS12770	COG0802	atpase or kinase
DW349_RS12780	COG1739	Uncharacterized protein family UPF0029
DW349_RS12790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DW349_RS12800	COG1902	pentaerythritol trinitrate reductase activity
DW349_RS12800	COG0446	pyridine nucleotide-disulphide oxidoreductase
DW349_RS12805	COG2169	Transcriptional regulator
DW349_RS12805	COG1917	Cupin 2, conserved barrel domain protein
DW349_RS12815	COG1522	sequence-specific DNA binding
DW349_RS12820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DW349_RS12830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DW349_RS12835	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DW349_RS12860	COG2197	response regulator
DW349_RS12890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DW349_RS12925	COG0418	dihydroorotase activity
DW349_RS12930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DW349_RS12935	COG0343	queuine tRNA-ribosyltransferase activity
DW349_RS12940	COG1862	Preprotein translocase
DW349_RS12985	COG0783	Belongs to the Dps family
DW349_RS12990	COG4206	TonB-dependent receptor
DW349_RS12995	COG4206	TonB-dependent receptor
DW349_RS13020	COG2205	protein histidine kinase activity
DW349_RS13020	COG4999	Histidine kinase
DW349_RS13020	COG3437	response regulator, receiver
DW349_RS13020	COG3850	Histidine kinase
DW349_RS13035	COG0137	argininosuccinate synthase activity
DW349_RS13040	COG2204	response regulator
DW349_RS13060	COG0131	Imidazoleglycerol-phosphate dehydratase
DW349_RS13065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DW349_RS13070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DW349_RS13075	COG0107	imidazoleglycerol-phosphate synthase activity
DW349_RS13105	COG2814	Major facilitator Superfamily
DW349_RS13110	COG1070	Carbohydrate kinase
DW349_RS13130	COG2909	trisaccharide binding
DW349_RS13135	COG1192	Involved in chromosome partitioning
DW349_RS13140	COG0205	6-phosphofructokinase activity
DW349_RS13145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DW349_RS13180	COG2264	protein methyltransferase activity
DW349_RS13200	COG0138	bifunctional purine biosynthesis protein purh
DW349_RS13205	COG0151	Belongs to the GarS family
DW349_RS13220	COG3025	triphosphatase activity
DW349_RS13225	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DW349_RS13230	COG1765	OsmC-like protein
DW349_RS13240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DW349_RS13240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DW349_RS13245	COG0284	orotidine-5'-phosphate decarboxylase activity
DW349_RS13260	COG4166	transmembrane transport
DW349_RS13265	COG0601	transmembrane transport
DW349_RS13270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DW349_RS13295	COG0129	dihydroxy-acid dehydratase activity
DW349_RS13300	COG1194	a g-specific adenine glycosylase
DW349_RS13305	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DW349_RS13320	COG1477	protein flavinylation
DW349_RS13345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DW349_RS13350	COG2259	Doxx family
DW349_RS13355	COG0084	hydrolase, TatD family'
DW349_RS13370	COG0793	Belongs to the peptidase S41A family
DW349_RS13375	COG4942	peptidase
DW349_RS13385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DW349_RS13395	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DW349_RS13405	COG1737	Transcriptional regulator
DW349_RS13415	COG0730	response to heat
DW349_RS13420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DW349_RS13435	COG0174	glutamine synthetase
DW349_RS13450	COG0028	Belongs to the TPP enzyme family
DW349_RS13465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DW349_RS13470	COG0583	DNA-binding transcription factor activity
DW349_RS13480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DW349_RS13485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DW349_RS13490	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DW349_RS13495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DW349_RS13500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DW349_RS13505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DW349_RS13540	COG0617	tRNA 3'-terminal CCA addition
DW349_RS13550	COG3304	Inner membrane component domain
DW349_RS13580	COG0163	prenyltransferase activity
DW349_RS13585	COG1946	Acyl-CoA thioesterase
DW349_RS13615	COG0395	ABC-type sugar transport system, permease component
DW349_RS13620	COG3842	ATPase activity
DW349_RS13630	COG1283	sodium-dependent phosphate transmembrane transporter activity
DW349_RS13635	COG0656	L-ascorbic acid biosynthetic process
DW349_RS13640	COG4213	ABC transporter substrate-binding protein
DW349_RS13645	COG1172	Belongs to the binding-protein-dependent transport system permease family
DW349_RS13650	COG1129	ABC transporter
DW349_RS13655	COG0673	inositol 2-dehydrogenase activity
DW349_RS13665	COG1609	Transcriptional regulator
DW349_RS13680	COG3122	Protein conserved in bacteria
DW349_RS13700	COG3254	rhamnose metabolic process
DW349_RS13705	COG1172	Belongs to the binding-protein-dependent transport system permease family
DW349_RS13710	COG1172	Belongs to the binding-protein-dependent transport system permease family
DW349_RS13715	COG1129	ABC transporter
DW349_RS13720	COG1879	ABC-type sugar transport system periplasmic component
DW349_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS13730	COG3347	Dehydrogenase
DW349_RS13735	COG4952	isomerase
DW349_RS13740	COG1304	FMN binding
DW349_RS13785	COG0438	transferase activity, transferring glycosyl groups
DW349_RS13795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DW349_RS13795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DW349_RS13820	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DW349_RS13825	COG2943	transferase activity, transferring hexosyl groups
DW349_RS13855	COG1944	ATP diphosphatase activity
DW349_RS13870	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DW349_RS13880	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DW349_RS13890	COG0165	Argininosuccinate lyase
DW349_RS13900	COG3842	ATPase activity
DW349_RS13905	COG0395	ABC-type sugar transport system, permease component
DW349_RS13910	COG1175	transmembrane transport
DW349_RS13920	COG1956	GAF domain-containing protein
DW349_RS13945	COG0431	NADPH-dependent FMN reductase
DW349_RS13980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DW349_RS13985	COG3383	formate dehydrogenase (NAD+) activity
DW349_RS14000	COG2267	carboxylic ester hydrolase activity
DW349_RS14015	COG2181	nitrate reductase activity
DW349_RS14015	COG0247	lactate metabolic process
DW349_RS14020	COG1902	pentaerythritol trinitrate reductase activity
DW349_RS14020	COG0446	pyridine nucleotide-disulphide oxidoreductase
DW349_RS14070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DW349_RS14075	COG1760	l-serine dehydratase
DW349_RS14110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DW349_RS14120	COG0493	'glutamate synthase
DW349_RS14125	COG0070	glutamate synthase
DW349_RS14125	COG0067	glutamate synthase
DW349_RS14125	COG0069	glutamate synthase activity
DW349_RS14135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DW349_RS14140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DW349_RS14175	COG0281	malic enzyme
DW349_RS14180	COG0254	rRNA binding
DW349_RS14185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DW349_RS14190	COG0018	arginyl-trna synthetase
DW349_RS14200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DW349_RS14205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DW349_RS14215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DW349_RS14235	COG0840	transmembrane signaling receptor activity
DW349_RS14245	COG3119	arylsulfatase activity
DW349_RS14265	COG0513	Belongs to the DEAD box helicase family
DW349_RS14270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DW349_RS14275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DW349_RS14290	COG1012	belongs to the aldehyde dehydrogenase family
DW349_RS14295	COG3724	N-succinylarginine dihydrolase activity
DW349_RS14320	COG0583	DNA-binding transcription factor activity
DW349_RS14330	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DW349_RS14335	COG0395	ABC-type sugar transport system, permease component
DW349_RS14340	COG1175	transmembrane transport
DW349_RS14350	COG1609	Transcriptional regulator
DW349_RS14355	COG0542	response to heat
DW349_RS14375	COG0546	phosphoglycolate phosphatase activity
DW349_RS14380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DW349_RS14380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DW349_RS14410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DW349_RS14415	COG1047	Peptidyl-prolyl cis-trans
DW349_RS14425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DW349_RS14430	COG0196	riboflavin kinase activity
DW349_RS14435	COG0728	peptidoglycan biosynthetic process
DW349_RS14440	COG0268	Binds directly to 16S ribosomal RNA
DW349_RS14450	COG0583	DNA-binding transcription factor activity
DW349_RS14460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DW349_RS14465	COG0484	heat shock protein binding
DW349_RS14475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DW349_RS14480	COG0497	DNA recombination
DW349_RS14485	COG0735	belongs to the Fur family
DW349_RS14490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DW349_RS14495	COG2914	Belongs to the UPF0125 (RnfH) family
DW349_RS14500	COG2867	negative regulation of translational initiation
DW349_RS14510	COG2133	pyrroloquinoline quinone binding
DW349_RS14545	COG0069	glutamate synthase activity
DW349_RS14560	COG2814	Major facilitator Superfamily
DW349_RS14620	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
DW349_RS14625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DW349_RS14695	COG2003	Belongs to the UPF0758 family
DW349_RS14730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DW349_RS14745	COG2988	succinylglutamate desuccinylase activity
DW349_RS14750	COG4160	amino acid transport
DW349_RS14755	COG4215	(ABC) transporter
DW349_RS14760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DW349_RS14770	COG0747	negative chemotaxis
DW349_RS14775	COG0601	transmembrane transport
DW349_RS14780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DW349_RS14785	COG0444	Belongs to the ABC transporter superfamily
DW349_RS14790	COG4608	Belongs to the ABC transporter superfamily
DW349_RS14800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DW349_RS14830	COG1216	Glycosyl transferase, family 2
DW349_RS14835	COG0417	DNA replication proofreading
DW349_RS14840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DW349_RS14845	COG0840	transmembrane signaling receptor activity
DW349_RS14850	COG1960	acyl-CoA dehydrogenase activity
DW349_RS14855	COG1960	acyl-CoA dehydrogenase activity
DW349_RS14860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DW349_RS14865	COG0363	glucosamine-6-phosphate deaminase activity
DW349_RS14870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DW349_RS14875	COG2188	Transcriptional regulator
DW349_RS14880	COG2971	BadF BadG BcrA BcrD
DW349_RS14910	COG0456	acetyltransferase
DW349_RS14915	COG1609	Transcriptional regulator
DW349_RS14925	COG4608	Belongs to the ABC transporter superfamily
DW349_RS14935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DW349_RS14945	COG4166	transmembrane transport
DW349_RS14975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DW349_RS14980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DW349_RS14985	COG1494	fructose-1,6-bisphosphatase
DW349_RS14995	COG0813	purine-nucleoside phosphorylase activity
DW349_RS15020	COG0784	Response regulator, receiver
DW349_RS15020	COG0643	Histidine kinase
DW349_RS15020	COG2198	Histidine kinase
DW349_RS15040	COG0840	transmembrane signaling receptor activity
DW349_RS15055	COG0189	ligase activity
DW349_RS15065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DW349_RS15085	COG3706	GGDEF domain
DW349_RS15095	COG4565	transcriptional regulatory protein
DW349_RS15135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DW349_RS15140	COG1611	Belongs to the LOG family
DW349_RS15145	COG3706	GGDEF domain
DW349_RS15165	COG0583	DNA-binding transcription factor activity
DW349_RS15170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DW349_RS15180	COG2195	Cleaves the N-terminal amino acid of tripeptides
DW349_RS15195	COG0513	Belongs to the DEAD box helicase family
DW349_RS15205	COG0134	indole-3-glycerol-phosphate synthase activity
DW349_RS15210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DW349_RS15215	COG0512	Glutamine amidotransferase of anthranilate synthase
DW349_RS15220	COG2198	Histidine kinase
DW349_RS15220	COG0784	Response regulator, receiver
DW349_RS15220	COG5002	protein histidine kinase activity
DW349_RS15225	COG0745	RESPONSE REGULATOR receiver
DW349_RS15245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DW349_RS15260	COG0784	Response regulator, receiver
DW349_RS15260	COG2205	protein histidine kinase activity
DW349_RS15335	COG0829	nickel cation binding
DW349_RS15340	COG0831	urea catabolic process
DW349_RS15345	COG0832	Belongs to the urease beta subunit family
DW349_RS15350	COG0804	urea catabolic process
DW349_RS15355	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DW349_RS15360	COG0830	nickel cation binding
DW349_RS15365	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DW349_RS15395	COG1902	pentaerythritol trinitrate reductase activity
DW349_RS15395	COG0446	pyridine nucleotide-disulphide oxidoreductase
DW349_RS15400	COG4302	ethanolamine ammonia-lyase activity
DW349_RS15405	COG4303	Ethanolamine ammonia lyase large subunit
DW349_RS15410	COG0004	ammonium transporteR
DW349_RS15415	COG2111	Na H antiporter
DW349_RS15415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DW349_RS15420	COG1006	Multisubunit Na H antiporter MnhC subunit
DW349_RS15425	COG0651	ATP synthesis coupled electron transport
DW349_RS15430	COG1863	multisubunit Na H antiporter MnhE subunit
DW349_RS15435	COG2212	antiporter activity
DW349_RS15440	COG1320	monovalent cation:proton antiporter activity
DW349_RS15450	COG2824	Alkylphosphonate utilization operon protein PhnA
DW349_RS15455	COG2814	Major facilitator Superfamily
DW349_RS15470	COG1335	isochorismatase
DW349_RS15475	COG1079	Belongs to the binding-protein-dependent transport system permease family
DW349_RS15485	COG1129	ABC transporter
DW349_RS15535	COG0237	dephospho-CoA kinase activity
DW349_RS15535	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DW349_RS15540	COG1280	lysine exporter protein (LysE YggA)
DW349_RS15545	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS15550	COG1063	alcohol dehydrogenase
DW349_RS15555	COG1172	Belongs to the binding-protein-dependent transport system permease family
DW349_RS15560	COG1129	ABC transporter
DW349_RS15565	COG1879	ABC-type sugar transport system periplasmic component
DW349_RS15570	COG1609	Transcriptional regulator
DW349_RS15575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DW349_RS15580	COG0318	PFAM AMP-dependent synthetase and ligase
DW349_RS15585	COG0183	Belongs to the thiolase family
DW349_RS15660	COG2313	pseudouridylate synthase activity
DW349_RS15665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DW349_RS15665	COG1522	sequence-specific DNA binding
DW349_RS15680	COG0488	(ABC) transporter
DW349_RS15685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DW349_RS15690	COG0697	spore germination
DW349_RS15700	COG0583	DNA-binding transcription factor activity
DW349_RS15705	COG1760	l-serine dehydratase
DW349_RS15715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DW349_RS15720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DW349_RS15720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DW349_RS15730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DW349_RS15785	COG0505	Belongs to the CarA family
DW349_RS15790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DW349_RS15805	COG0330	HflC and HflK could
DW349_RS15845	COG1132	(ABC) transporter
DW349_RS15850	COG1132	(ABC) transporter
DW349_RS15860	COG1271	oxidase subunit
DW349_RS15865	COG1294	oxidase, subunit
DW349_RS15870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DW349_RS15880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DW349_RS15885	COG0561	phosphatase activity
DW349_RS15890	COG0546	phosphoglycolate phosphatase activity
DW349_RS15895	COG0513	Belongs to the DEAD box helicase family
DW349_RS15900	COG0697	spore germination
DW349_RS15905	COG1846	Transcriptional regulator
DW349_RS15915	COG0583	DNA-binding transcription factor activity
DW349_RS15920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DW349_RS15930	COG0183	Belongs to the thiolase family
DW349_RS15935	COG2031	fatty acid transporter
DW349_RS15980	COG3153	acetyltransferase
DW349_RS15980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DW349_RS15995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DW349_RS16010	COG4251	negative regulation of phosphorylation
DW349_RS16015	COG0745	RESPONSE REGULATOR receiver
DW349_RS16040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DW349_RS16045	COG1082	Xylose isomerase domain protein TIM barrel
DW349_RS16045	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DW349_RS16055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DW349_RS16085	COG0488	(ABC) transporter
DW349_RS16095	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DW349_RS16110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DW349_RS16155	COG2208	phosphoserine phosphatase activity
DW349_RS16155	COG2770	Histidine kinase
DW349_RS16185	COG0583	DNA-binding transcription factor activity
DW349_RS16200	COG2159	amidohydrolase
DW349_RS16205	COG0179	Fumarylacetoacetate (FAA) hydrolase
DW349_RS16215	COG0667	Aldo Keto reductase
DW349_RS16240	COG1322	Protein conserved in bacteria
DW349_RS16255	COG3263	regulation of cellular component size
DW349_RS16285	COG0840	transmembrane signaling receptor activity
DW349_RS16295	COG1653	transport
DW349_RS16300	COG1175	transmembrane transport
DW349_RS16305	COG0395	ABC-type sugar transport system, permease component
DW349_RS16310	COG0366	Alpha amylase catalytic
DW349_RS16315	COG1609	Transcriptional regulator
DW349_RS16320	COG0456	acetyltransferase
DW349_RS16345	COG2154	pterin-4-alpha-carbinolamine dehydratase
DW349_RS16365	COG0842	Transport permease protein
DW349_RS16370	COG1131	(ABC) transporter
DW349_RS16380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DW349_RS16395	COG2814	Major facilitator Superfamily
DW349_RS16400	COG4989	oxidoreductase activity
DW349_RS16405	COG2855	membrane
DW349_RS16420	COG0589	response to stress
DW349_RS16455	COG0705	Rhomboid family
DW349_RS16465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DW349_RS16480	COG3220	belongs to the UPF0276 family
DW349_RS16495	COG0840	transmembrane signaling receptor activity
DW349_RS16510	COG1960	acyl-CoA dehydrogenase activity
DW349_RS16515	COG0583	DNA-binding transcription factor activity
DW349_RS16520	COG0366	Alpha amylase catalytic
DW349_RS16525	COG0366	Alpha amylase catalytic
DW349_RS16540	COG1983	PspC domain protein
DW349_RS16550	COG1842	Phage shock protein A
DW349_RS16560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DW349_RS16570	COG0347	Belongs to the P(II) protein family
DW349_RS16575	COG0004	ammonium transporteR
DW349_RS16595	COG3608	succinylglutamate desuccinylase aspartoacylase
DW349_RS16615	COG1079	Belongs to the binding-protein-dependent transport system permease family
DW349_RS16620	COG4603	Belongs to the binding-protein-dependent transport system permease family
DW349_RS16625	COG3845	ABC transporter
DW349_RS16630	COG1744	ABC transporter substrate-binding protein PnrA-like
DW349_RS16645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DW349_RS16650	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DW349_RS16655	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DW349_RS16665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DW349_RS16670	COG3180	Ammonia monooxygenase
DW349_RS16675	COG0084	hydrolase, TatD family'
DW349_RS16690	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DW349_RS16705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DW349_RS16730	COG1074	ATP-dependent DNA helicase activity
DW349_RS16735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DW349_RS16775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DW349_RS16795	COG0824	Thioesterase
DW349_RS16805	COG0492	ferredoxin-NADP+ reductase activity
DW349_RS16815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DW349_RS16820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DW349_RS16855	COG0572	uridine kinase
DW349_RS16860	COG1177	transmembrane transport
DW349_RS16875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DW349_RS16910	COG0751	glycine-tRNA ligase activity
DW349_RS16915	COG0752	glycyl-tRNA synthetase alpha subunit
DW349_RS16920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DW349_RS16925	COG0569	domain protein
DW349_RS16930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DW349_RS16940	COG0242	peptide deformylase activity
DW349_RS16945	COG0758	DNA mediated transformation
DW349_RS16950	COG0009	L-threonylcarbamoyladenylate synthase
DW349_RS16965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DW349_RS16970	COG1309	transcriptional regulator
DW349_RS16985	COG0527	aspartate kinase activity
DW349_RS16990	COG1917	Cupin 2, conserved barrel domain protein
DW349_RS16995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DW349_RS17010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DW349_RS17030	COG1741	Belongs to the pirin family
DW349_RS17040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DW349_RS17045	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DW349_RS17055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DW349_RS17060	COG1758	RNA polymerase activity
DW349_RS17085	COG3842	ATPase activity
DW349_RS17090	COG2011	ABC-type metal ion transport system permease component
DW349_RS17105	COG1280	lysine exporter protein (LysE YggA)
DW349_RS17115	COG0596	Alpha beta hydrolase
DW349_RS17125	COG2116	formate transmembrane transporter activity
DW349_RS17130	COG3707	response regulator
DW349_RS17140	COG1028	Short-chain dehydrogenase reductase Sdr
DW349_RS17145	COG0583	DNA-binding transcription factor activity
DW349_RS17150	COG1715	Restriction endonuclease
DW349_RS17155	COG3645	SOS response
DW349_RS17160	COG1561	YicC-like family, N-terminal region
DW349_RS17165	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DW349_RS17175	COG0339	signal peptide processing
DW349_RS17185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DW349_RS17195	COG1280	lysine exporter protein (LysE YggA)
DW349_RS17200	COG2814	Major facilitator Superfamily
DW349_RS17205	COG0667	Aldo Keto reductase
DW349_RS17210	COG0667	Aldo Keto reductase
DW349_RS17230	COG0023	Translation Initiation Factor
DW349_RS17240	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DW349_RS17250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DW349_RS17255	COG2267	carboxylic ester hydrolase activity
DW349_RS17265	COG0706	membrane insertase activity
DW349_RS17270	COG0594	ribonuclease P activity