locus-tag	class	description
IOD16_RS00100	COG1672	PFAM Archaeal ATPase
IOD16_RS00100	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IOD16_RS00105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD16_RS00120	COG2124	cytochrome p450
IOD16_RS00185	COG2197	response regulator
IOD16_RS00215	COG0778	Nitroreductase
IOD16_RS00230	COG0588	phosphoglycerate mutase activity
IOD16_RS00240	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD16_RS00250	COG2860	membrane
IOD16_RS00255	COG0745	RESPONSE REGULATOR receiver
IOD16_RS00265	COG0395	ABC-type sugar transport system, permease component
IOD16_RS00270	COG1175	transmembrane transport
IOD16_RS00275	COG1653	transport
IOD16_RS00285	COG1349	DNA-binding transcription factor activity
IOD16_RS00295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD16_RS00305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IOD16_RS00325	COG0745	RESPONSE REGULATOR receiver
IOD16_RS00330	COG5002	protein histidine kinase activity
IOD16_RS00335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOD16_RS00340	COG0315	cyclic pyranopterin monophosphate synthase activity
IOD16_RS00340	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD16_RS00350	COG1970	mechanosensitive ion channel activity
IOD16_RS00375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOD16_RS00380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD16_RS00390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD16_RS00430	COG1309	transcriptional regulator
IOD16_RS00435	COG0515	serine threonine protein kinase
IOD16_RS00450	COG1522	sequence-specific DNA binding
IOD16_RS00470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD16_RS00475	COG0084	hydrolase, TatD family'
IOD16_RS00480	COG3583	domain protein
IOD16_RS00485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD16_RS00490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD16_RS00495	COG2011	ABC-type metal ion transport system permease component
IOD16_RS00505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IOD16_RS00510	COG0488	(ABC) transporter
IOD16_RS00515	COG3599	regulation of cell shape
IOD16_RS00530	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS00535	COG0193	aminoacyl-tRNA hydrolase activity
IOD16_RS00545	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IOD16_RS00555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IOD16_RS00585	COG2133	pyrroloquinoline quinone binding
IOD16_RS00605	COG3956	TIGRFAM MazG family protein
IOD16_RS00615	COG0793	Belongs to the peptidase S41A family
IOD16_RS00615	COG4946	Tricorn protease homolog
IOD16_RS00625	COG2837	iron assimilation
IOD16_RS00635	COG0672	)-iron permease
IOD16_RS00660	COG0148	phosphopyruvate hydratase activity
IOD16_RS00695	COG0601	transmembrane transport
IOD16_RS00700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD16_RS00710	COG4608	Belongs to the ABC transporter superfamily
IOD16_RS00735	COG0714	Associated with various cellular activities
IOD16_RS00775	COG2197	response regulator
IOD16_RS00785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IOD16_RS00800	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IOD16_RS00835	COG0183	Belongs to the thiolase family
IOD16_RS00840	COG2755	lipolytic protein G-D-S-L family
IOD16_RS00870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IOD16_RS00880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD16_RS00890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD16_RS00900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOD16_RS00905	COG1331	Highly conserved protein containing a thioredoxin domain
IOD16_RS00940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IOD16_RS00960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS00970	COG0114	fumarate hydratase activity
IOD16_RS00975	COG0492	ferredoxin-NADP+ reductase activity
IOD16_RS01000	COG1722	exodeoxyribonuclease VII activity
IOD16_RS01010	COG1570	exodeoxyribonuclease VII activity
IOD16_RS01020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IOD16_RS01030	COG1132	(ABC) transporter
IOD16_RS01035	COG3629	intracellular signal transduction
IOD16_RS01035	COG3903	Transcriptional regulator
IOD16_RS01040	COG0419	ATPase involved in DNA repair
IOD16_RS01045	COG0420	3'-5' exonuclease activity
IOD16_RS01070	COG0012	GTP binding
IOD16_RS01075	COG2161	toxin-antitoxin pair type II binding
IOD16_RS01080	COG4115	mRNA cleavage
IOD16_RS01085	COG1051	belongs to the nudix hydrolase family
IOD16_RS01090	COG2154	pterin-4-alpha-carbinolamine dehydratase
IOD16_RS01100	COG4149	molybdate abc transporter
IOD16_RS01105	COG3842	ATPase activity
IOD16_RS01120	COG1131	(ABC) transporter
IOD16_RS01130	COG0745	RESPONSE REGULATOR receiver
IOD16_RS01135	COG2205	protein histidine kinase activity
IOD16_RS01145	COG0180	Tryptophanyl-tRNA synthetase
IOD16_RS01160	COG1217	gtp-binding protein TYPA
IOD16_RS01165	COG0747	negative chemotaxis
IOD16_RS01175	COG0601	transmembrane transport
IOD16_RS01190	COG4608	Belongs to the ABC transporter superfamily
IOD16_RS01195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD16_RS01225	COG2171	N-acyltransferase activity
IOD16_RS01230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD16_RS01235	COG1611	Belongs to the LOG family
IOD16_RS01255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOD16_RS01260	COG0463	Glycosyl transferase, family 2
IOD16_RS01270	COG4988	ABC transporter
IOD16_RS01280	COG1271	oxidase subunit
IOD16_RS01305	COG0519	Catalyzes the synthesis of GMP from XMP
IOD16_RS01310	COG1024	Enoyl-CoA hydratase
IOD16_RS01325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IOD16_RS01335	COG2814	Major facilitator Superfamily
IOD16_RS01340	COG0297	glycogen (starch) synthase activity
IOD16_RS01345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IOD16_RS01350	COG4122	O-methyltransferase activity
IOD16_RS01365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD16_RS01370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD16_RS01375	COG4733	cellulase activity
IOD16_RS01375	COG5297	Belongs to the glycosyl hydrolase family 6
IOD16_RS01395	COG2239	Acts as a magnesium transporter
IOD16_RS01410	COG2301	Belongs to the HpcH HpaI aldolase family
IOD16_RS01460	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS01485	COG0598	Magnesium transport protein CorA
IOD16_RS01540	COG0513	Belongs to the DEAD box helicase family
IOD16_RS01580	COG2267	carboxylic ester hydrolase activity
IOD16_RS01605	COG0243	molybdopterin cofactor binding
IOD16_RS01610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD16_RS01615	COG2223	nitrite transmembrane transporter activity
IOD16_RS01620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD16_RS01620	COG2146	nitrite reductase [NAD(P)H] activity
IOD16_RS01625	COG2146	nitrite reductase [NAD(P)H] activity
IOD16_RS01625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD16_RS01640	COG1741	Belongs to the pirin family
IOD16_RS01675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD16_RS01680	COG0475	glutathione-regulated potassium exporter activity
IOD16_RS01680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD16_RS01690	COG0745	RESPONSE REGULATOR receiver
IOD16_RS01720	COG0612	Peptidase, M16
IOD16_RS01735	COG1846	Transcriptional regulator
IOD16_RS01740	COG1940	carbohydrate kinase activity
IOD16_RS01770	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IOD16_RS01830	COG0431	NADPH-dependent FMN reductase
IOD16_RS01890	COG0557	exoribonuclease II activity
IOD16_RS01925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD16_RS01950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IOD16_RS01960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IOD16_RS01960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IOD16_RS01970	COG1309	transcriptional regulator
IOD16_RS01975	COG4221	oxidoreductase activity
IOD16_RS02010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IOD16_RS02010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD16_RS02030	COG1309	transcriptional regulator
IOD16_RS02035	COG0477	Major facilitator Superfamily
IOD16_RS02045	COG0174	glutamine synthetase
IOD16_RS02075	COG3655	Transcriptional regulator
IOD16_RS02090	COG1522	sequence-specific DNA binding
IOD16_RS02100	COG0519	Catalyzes the synthesis of GMP from XMP
IOD16_RS02100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD16_RS02115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IOD16_RS02140	COG0174	glutamine synthetase
IOD16_RS02180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOD16_RS02215	COG1615	UPF0182 protein
IOD16_RS02240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IOD16_RS02245	COG2884	Cell division ATP-binding protein ftsE
IOD16_RS02250	COG2177	Part of the ABC transporter FtsEX involved in
IOD16_RS02255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IOD16_RS02265	COG2197	response regulator
IOD16_RS02270	COG4585	Histidine kinase
IOD16_RS02310	COG1643	Atp-dependent helicase
IOD16_RS02315	COG0463	Glycosyl transferase, family 2
IOD16_RS02320	COG0456	acetyltransferase
IOD16_RS02320	COG0454	-acetyltransferase
IOD16_RS02375	COG1051	belongs to the nudix hydrolase family
IOD16_RS02380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD16_RS02380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD16_RS02415	COG4585	Histidine kinase
IOD16_RS02420	COG2197	response regulator
IOD16_RS02525	COG4941	Belongs to the sigma-70 factor family
IOD16_RS02535	COG1609	Transcriptional regulator
IOD16_RS02560	COG1175	transmembrane transport
IOD16_RS02565	COG0395	ABC-type sugar transport system, permease component
IOD16_RS02585	COG2197	response regulator
IOD16_RS02600	COG1136	(ABC) transporter
IOD16_RS02610	COG4585	Histidine kinase
IOD16_RS02615	COG0596	Alpha beta hydrolase
IOD16_RS02630	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS02670	COG4585	Histidine kinase
IOD16_RS02675	COG2197	response regulator
IOD16_RS02695	COG0124	histidyl-tRNA synthetase
IOD16_RS02710	COG1120	ATPase activity
IOD16_RS02740	COG0431	NADPH-dependent FMN reductase
IOD16_RS02745	COG0604	alcohol dehydrogenase
IOD16_RS02755	COG2197	response regulator
IOD16_RS02780	COG3903	Transcriptional regulator
IOD16_RS02780	COG3629	intracellular signal transduction
IOD16_RS02795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IOD16_RS02800	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IOD16_RS02805	COG0235	Class ii aldolase
IOD16_RS02810	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IOD16_RS02820	COG5002	protein histidine kinase activity
IOD16_RS02825	COG0745	RESPONSE REGULATOR receiver
IOD16_RS02835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD16_RS02850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD16_RS02875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD16_RS02885	COG1335	isochorismatase
IOD16_RS02890	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IOD16_RS02930	COG3509	depolymerase
IOD16_RS02940	COG1234	tRNA 3'-trailer cleavage
IOD16_RS02945	COG3386	PFAM SMP-30 Gluconolaconase
IOD16_RS02960	COG1234	tRNA 3'-trailer cleavage
IOD16_RS02980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IOD16_RS02985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IOD16_RS03000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS03015	COG4585	Histidine kinase
IOD16_RS03020	COG2201	protein-glutamate methylesterase activity
IOD16_RS03025	COG0586	Pfam SNARE associated Golgi protein
IOD16_RS03095	COG2949	membrane
IOD16_RS03100	COG1316	TRANSCRIPTIONal
IOD16_RS03115	COG4213	ABC transporter substrate-binding protein
IOD16_RS03145	COG1278	Cold shock
IOD16_RS03170	COG4279	zinc finger
IOD16_RS03175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD16_RS03225	COG3629	intracellular signal transduction
IOD16_RS03225	COG3903	Transcriptional regulator
IOD16_RS03235	COG1376	ErfK ybiS ycfS ynhG family protein
IOD16_RS03240	COG0488	(ABC) transporter
IOD16_RS03250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IOD16_RS03255	COG0433	COG0433 Predicted ATPase
IOD16_RS03290	COG4221	oxidoreductase activity
IOD16_RS03300	COG1846	Transcriptional regulator
IOD16_RS03305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IOD16_RS03320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD16_RS03360	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS03360	COG3693	PFAM glycoside hydrolase, family 10
IOD16_RS03360	COG2382	esterase
IOD16_RS03375	COG0506	proline dehydrogenase activity
IOD16_RS03380	COG1012	belongs to the aldehyde dehydrogenase family
IOD16_RS03395	COG0706	membrane insertase activity
IOD16_RS03420	COG1012	belongs to the aldehyde dehydrogenase family
IOD16_RS03475	COG1609	Transcriptional regulator
IOD16_RS03490	COG3336	cytochrome c oxidase
IOD16_RS03505	COG1309	transcriptional regulator
IOD16_RS03510	COG0629	single-stranded DNA binding
IOD16_RS03525	COG2902	Dehydrogenase
IOD16_RS03545	COG0366	Alpha amylase catalytic
IOD16_RS03570	COG0366	Alpha amylase catalytic
IOD16_RS03585	COG0668	transmembrane transport
IOD16_RS03590	COG1505	serine-type exopeptidase activity
IOD16_RS03610	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IOD16_RS03630	COG2337	Toxic component of a toxin-antitoxin (TA) module
IOD16_RS03645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOD16_RS03675	COG4552	Acetyltransferase involved in intracellular survival and related
IOD16_RS03705	COG0583	DNA-binding transcription factor activity
IOD16_RS03710	COG0544	peptidyl-prolyl cis-trans isomerase activity
IOD16_RS03715	COG0740	serine-type endopeptidase activity
IOD16_RS03720	COG0740	serine-type endopeptidase activity
IOD16_RS03725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IOD16_RS03745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOD16_RS03780	COG0525	valine-tRNA ligase activity
IOD16_RS03785	COG0285	dihydrofolate synthase activity
IOD16_RS03825	COG0105	UTP biosynthetic process
IOD16_RS03840	COG1131	(ABC) transporter
IOD16_RS03875	COG1530	ribonuclease E activity
IOD16_RS03880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IOD16_RS03885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IOD16_RS03890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IOD16_RS03915	COG0477	Major facilitator Superfamily
IOD16_RS03930	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IOD16_RS03960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IOD16_RS03965	COG0799	negative regulation of ribosome biogenesis
IOD16_RS03970	COG0406	alpha-ribazole phosphatase activity
IOD16_RS03975	COG2755	lipolytic protein G-D-S-L family
IOD16_RS03980	COG1307	EDD domain protein, DegV family
IOD16_RS04010	COG0268	Binds directly to 16S ribosomal RNA
IOD16_RS04015	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS04065	COG0481	GTPase activity
IOD16_RS04080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD16_RS04095	COG2070	2-Nitropropane dioxygenase
IOD16_RS04105	COG0531	amino acid
IOD16_RS04110	COG0604	alcohol dehydrogenase
IOD16_RS04135	COG0693	protein deglycase activity
IOD16_RS04150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD16_RS04155	COG1116	anion transmembrane transporter activity
IOD16_RS04200	COG1420	regulation of RNA biosynthetic process
IOD16_RS04205	COG0484	heat shock protein binding
IOD16_RS04215	COG0596	Alpha beta hydrolase
IOD16_RS04220	COG0537	adenosine 5'-monophosphoramidase activity
IOD16_RS04235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IOD16_RS04255	COG3415	Transposase
IOD16_RS04255	COG2801	Transposase and inactivated derivatives
IOD16_RS04260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOD16_RS04265	COG1381	Involved in DNA repair and RecF pathway recombination
IOD16_RS04270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOD16_RS04295	COG0701	Predicted permease
IOD16_RS04325	COG0423	glycine-tRNA ligase activity
IOD16_RS04370	COG3340	Belongs to the peptidase S51 family
IOD16_RS04380	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IOD16_RS04395	COG1595	DNA-templated transcription, initiation
IOD16_RS04410	COG4106	trans-aconitate 2-methyltransferase activity
IOD16_RS04440	COG0477	Major facilitator Superfamily
IOD16_RS04450	COG2337	Toxic component of a toxin-antitoxin (TA) module
IOD16_RS04465	COG1131	(ABC) transporter
IOD16_RS04475	COG1476	TRANSCRIPTIONal
IOD16_RS04495	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
IOD16_RS04500	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IOD16_RS04515	COG3300	MHYT domain
IOD16_RS04515	COG5001	Diguanylate cyclase
IOD16_RS04525	COG2814	Major facilitator Superfamily
IOD16_RS04535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOD16_RS04540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOD16_RS04550	COG2755	lipolytic protein G-D-S-L family
IOD16_RS04585	COG1132	(ABC) transporter
IOD16_RS04590	COG1132	(ABC) transporter
IOD16_RS04600	COG0515	serine threonine protein kinase
IOD16_RS04620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD16_RS04625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD16_RS04655	COG3201	nicotinamide mononucleotide transporter
IOD16_RS04660	COG1653	transport
IOD16_RS04670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IOD16_RS04705	COG0563	adenylate kinase activity
IOD16_RS04730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOD16_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS04765	COG0321	lipoyl(octanoyl) transferase activity
IOD16_RS04780	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD16_RS04785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD16_RS04795	COG1309	transcriptional regulator
IOD16_RS04805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IOD16_RS04815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD16_RS04820	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IOD16_RS04845	COG0667	Aldo Keto reductase
IOD16_RS04875	COG2814	Major facilitator Superfamily
IOD16_RS04880	COG0789	Transcriptional regulator
IOD16_RS04890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IOD16_RS04910	COG0583	DNA-binding transcription factor activity
IOD16_RS04915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD16_RS04930	COG1845	cytochrome c oxidase, subunit III
IOD16_RS04935	COG2010	Cytochrome c
IOD16_RS04945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IOD16_RS04985	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS04990	COG3903	Transcriptional regulator
IOD16_RS04990	COG3629	intracellular signal transduction
IOD16_RS05015	COG0003	Pfam Anion-transporting ATPase
IOD16_RS05025	COG1940	carbohydrate kinase activity
IOD16_RS05075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IOD16_RS05080	COG2815	serine threonine protein kinase
IOD16_RS05080	COG0515	serine threonine protein kinase
IOD16_RS05100	COG0142	geranyltranstransferase activity
IOD16_RS05155	COG1595	DNA-templated transcription, initiation
IOD16_RS05175	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IOD16_RS05180	COG1201	RNA secondary structure unwinding
IOD16_RS05185	COG0443	Heat shock 70 kDa protein
IOD16_RS05190	COG2814	Major facilitator Superfamily
IOD16_RS05215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IOD16_RS05220	COG2137	regulation of response to DNA damage stimulus
IOD16_RS05235	COG0800	Aldolase
IOD16_RS05280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD16_RS05285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IOD16_RS05295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD16_RS05305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOD16_RS05330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IOD16_RS05340	COG1196	nuclear chromosome segregation
IOD16_RS05360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD16_RS05375	COG2205	protein histidine kinase activity
IOD16_RS05380	COG0745	RESPONSE REGULATOR receiver
IOD16_RS05385	COG1126	abc transporter atp-binding protein
IOD16_RS05395	COG0765	amino acid transport
IOD16_RS05400	COG0765	amino acid transport
IOD16_RS05465	COG1515	deoxyribonuclease V activity
IOD16_RS05470	COG1486	melibiose metabolic process
IOD16_RS05475	COG0583	DNA-binding transcription factor activity
IOD16_RS05480	COG0657	acetylesterase activity
IOD16_RS05485	COG2814	Major facilitator Superfamily
IOD16_RS05490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD16_RS05495	COG2936	dipeptidyl-peptidase activity
IOD16_RS05500	COG1196	nuclear chromosome segregation
IOD16_RS05500	COG0739	heme binding
IOD16_RS05500	COG0741	lytic transglycosylase activity
IOD16_RS05505	COG4991	sh3 domain protein
IOD16_RS05515	COG0823	Involved in the tonB-independent uptake of proteins
IOD16_RS05515	COG1506	peptidase
IOD16_RS05515	COG4946	Tricorn protease homolog
IOD16_RS05520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOD16_RS05525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IOD16_RS05545	COG0123	including yeast histone deacetylase and acetoin utilization protein
IOD16_RS05605	COG1595	DNA-templated transcription, initiation
IOD16_RS05620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD16_RS05630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD16_RS05635	COG4948	Mandelate Racemase Muconate Lactonizing
IOD16_RS05680	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD16_RS05680	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD16_RS05695	COG1490	D-aminoacyl-tRNA deacylase activity
IOD16_RS05715	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IOD16_RS05715	COG2508	Transcriptional regulator
IOD16_RS05715	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IOD16_RS05715	COG2508	Transcriptional regulator
IOD16_RS05730	COG2313	pseudouridylate synthase activity
IOD16_RS05750	COG4213	ABC transporter substrate-binding protein
IOD16_RS05760	COG4214	carbohydrate transport
IOD16_RS05765	COG1940	carbohydrate kinase activity
IOD16_RS05800	COG0483	inositol monophosphate 1-phosphatase activity
IOD16_RS05820	COG0756	dUTP diphosphatase activity
IOD16_RS05855	COG0569	domain protein
IOD16_RS05860	COG0531	amino acid
IOD16_RS05865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD16_RS05870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IOD16_RS05885	COG0745	RESPONSE REGULATOR receiver
IOD16_RS05890	COG2205	protein histidine kinase activity
IOD16_RS05980	COG1201	RNA secondary structure unwinding
IOD16_RS06075	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD16_RS06075	COG1024	Enoyl-CoA hydratase
IOD16_RS06080	COG0183	Belongs to the thiolase family
IOD16_RS06105	COG2197	response regulator
IOD16_RS06120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IOD16_RS06130	COG3253	May function as heme-dependent peroxidase
IOD16_RS06155	COG1404	Belongs to the peptidase S8 family
IOD16_RS06175	COG3220	belongs to the UPF0276 family
IOD16_RS06195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD16_RS06220	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS06225	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS06280	COG3647	Membrane
IOD16_RS06295	COG5006	permease, DMT superfamily
IOD16_RS06305	COG1793	dna ligase
IOD16_RS06355	COG0488	(ABC) transporter
IOD16_RS06370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IOD16_RS06385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD16_RS06390	COG2326	polyphosphate kinase activity
IOD16_RS06395	COG2706	6-phosphogluconolactonase activity
IOD16_RS06400	COG2755	lipolytic protein G-D-S-L family
IOD16_RS06415	COG1316	TRANSCRIPTIONal
IOD16_RS06430	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS06455	COG0653	protein targeting
IOD16_RS06460	COG0477	Major facilitator Superfamily
IOD16_RS06465	COG4770	biotin carboxylase activity
IOD16_RS06480	COG0596	Alpha beta hydrolase
IOD16_RS06500	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS06505	COG0183	Belongs to the thiolase family
IOD16_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS06530	COG1309	transcriptional regulator
IOD16_RS06535	COG2318	DinB family
IOD16_RS06570	COG0668	transmembrane transport
IOD16_RS06585	COG0475	glutathione-regulated potassium exporter activity
IOD16_RS06610	COG1160	GTP binding
IOD16_RS06615	COG2197	response regulator
IOD16_RS06620	COG4585	Histidine kinase
IOD16_RS06705	COG1418	mRNA catabolic process
IOD16_RS06715	COG1819	glycosyl
IOD16_RS06765	COG0515	serine threonine protein kinase
IOD16_RS06850	COG0443	Heat shock 70 kDa protein
IOD16_RS06865	COG0494	nUDIX hydrolase
IOD16_RS06875	COG1056	cytidyltransferase-related domain
IOD16_RS06875	COG1051	belongs to the nudix hydrolase family
IOD16_RS06880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD16_RS06915	COG4935	Belongs to the peptidase S8 family
IOD16_RS06915	COG2234	aminopeptidase activity
IOD16_RS06920	COG3629	intracellular signal transduction
IOD16_RS06920	COG3903	Transcriptional regulator
IOD16_RS06930	COG3693	PFAM glycoside hydrolase, family 10
IOD16_RS06935	COG4715	Zinc finger, swim domain protein
IOD16_RS06940	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IOD16_RS06945	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IOD16_RS06950	COG0714	Associated with various cellular activities
IOD16_RS06955	COG3831	ATPase activity
IOD16_RS06975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS06990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IOD16_RS06995	COG0456	acetyltransferase
IOD16_RS07000	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOD16_RS07005	COG1846	Transcriptional regulator
IOD16_RS07025	COG0142	geranyltranstransferase activity
IOD16_RS07050	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IOD16_RS07105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS07130	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS07180	COG1595	DNA-templated transcription, initiation
IOD16_RS07320	COG3409	Peptidoglycan-binding domain 1 protein
IOD16_RS07335	COG5297	Belongs to the glycosyl hydrolase family 6
IOD16_RS07345	COG0671	phosphoesterase, PA-phosphatase related
IOD16_RS07350	COG3629	intracellular signal transduction
IOD16_RS07350	COG3903	Transcriptional regulator
IOD16_RS07380	COG3655	Transcriptional regulator
IOD16_RS07385	COG1131	(ABC) transporter
IOD16_RS07410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IOD16_RS07435	COG2814	Major facilitator Superfamily
IOD16_RS07455	COG1725	Transcriptional regulator
IOD16_RS07460	COG1131	(ABC) transporter
IOD16_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS07505	COG4585	Histidine kinase
IOD16_RS07510	COG2197	response regulator
IOD16_RS07515	COG4152	abc transporter atp-binding protein
IOD16_RS07520	COG1668	transmembrane transport
IOD16_RS07525	COG1595	DNA-templated transcription, initiation
IOD16_RS07565	COG4172	Belongs to the ABC transporter superfamily
IOD16_RS07570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD16_RS07595	COG4948	Mandelate Racemase Muconate Lactonizing
IOD16_RS07600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD16_RS07610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IOD16_RS07665	COG2197	response regulator
IOD16_RS07680	COG4585	Histidine kinase
IOD16_RS07685	COG2197	response regulator
IOD16_RS07710	COG1131	(ABC) transporter
IOD16_RS07720	COG2197	response regulator
IOD16_RS07725	COG1609	Transcriptional regulator
IOD16_RS07740	COG0395	ABC-type sugar transport system, permease component
IOD16_RS07750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOD16_RS07780	COG2814	Major facilitator Superfamily
IOD16_RS07800	COG5297	Belongs to the glycosyl hydrolase family 6
IOD16_RS07805	COG2197	response regulator
IOD16_RS07820	COG3537	Alpha-1,2-mannosidase
IOD16_RS07835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD16_RS07840	COG4585	Histidine kinase
IOD16_RS07880	COG0154	amidase activity
IOD16_RS07920	COG0640	Transcriptional regulator
IOD16_RS07945	COG1136	(ABC) transporter
IOD16_RS07945	COG0577	efflux transmembrane transporter activity
IOD16_RS07950	COG0577	efflux transmembrane transporter activity
IOD16_RS07950	COG1136	(ABC) transporter
IOD16_RS07990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS07995	COG4585	Histidine kinase
IOD16_RS08090	COG1940	carbohydrate kinase activity
IOD16_RS08095	COG4166	transmembrane transport
IOD16_RS08105	COG0601	transmembrane transport
IOD16_RS08110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD16_RS08115	COG0444	Belongs to the ABC transporter superfamily
IOD16_RS08160	COG2378	regulation of single-species biofilm formation
IOD16_RS08165	COG1793	dna ligase
IOD16_RS08170	COG2318	DinB family
IOD16_RS08180	COG5002	protein histidine kinase activity
IOD16_RS08180	COG5001	Diguanylate cyclase
IOD16_RS08180	COG3447	MASE1 domain protein
IOD16_RS08190	COG0632	four-way junction helicase activity
IOD16_RS08195	COG2255	four-way junction helicase activity
IOD16_RS08210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD16_RS08215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOD16_RS08220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IOD16_RS08225	COG3903	Transcriptional regulator
IOD16_RS08225	COG3629	intracellular signal transduction
IOD16_RS08240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD16_RS08260	COG0124	histidyl-tRNA synthetase
IOD16_RS08265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD16_RS08285	COG3759	membrane
IOD16_RS08320	COG0277	FAD linked oxidase domain protein
IOD16_RS08330	COG1309	transcriptional regulator
IOD16_RS08355	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS08360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD16_RS08405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IOD16_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS08435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IOD16_RS08465	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IOD16_RS08470	COG2205	protein histidine kinase activity
IOD16_RS08475	COG0745	RESPONSE REGULATOR receiver
IOD16_RS08490	COG0737	Belongs to the 5'-nucleotidase family
IOD16_RS08495	COG3663	DNA glycosylase
IOD16_RS08510	COG4552	Acetyltransferase involved in intracellular survival and related
IOD16_RS08550	COG2244	polysaccharide biosynthetic process
IOD16_RS08580	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IOD16_RS08610	COG1672	PFAM Archaeal ATPase
IOD16_RS08610	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IOD16_RS08695	COG1660	Displays ATPase and GTPase activities
IOD16_RS08730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD16_RS08730	COG0596	Alpha beta hydrolase
IOD16_RS08730	COG2226	methyltransferase
IOD16_RS08735	COG0765	amino acid transport
IOD16_RS08740	COG1126	abc transporter atp-binding protein
IOD16_RS08745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD16_RS08755	COG0765	amino acid transport
IOD16_RS08760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS08785	COG1024	Enoyl-CoA hydratase
IOD16_RS08810	COG1295	ribonuclease BN
IOD16_RS08815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD16_RS08825	COG0765	amino acid transport
IOD16_RS08875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD16_RS08895	COG0395	ABC-type sugar transport system, permease component
IOD16_RS08900	COG2723	6-phospho-beta-galactosidase activity
IOD16_RS08915	COG5416	Lipopolysaccharide assembly protein A domain
IOD16_RS08920	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD16_RS08920	COG2319	Wd-40 repeat
IOD16_RS08930	COG1940	carbohydrate kinase activity
IOD16_RS08935	COG2115	Belongs to the xylose isomerase family
IOD16_RS08940	COG1070	Carbohydrate kinase
IOD16_RS09010	COG0859	PFAM glycosyl transferase family 9
IOD16_RS09020	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS09025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IOD16_RS09030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IOD16_RS09030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IOD16_RS09035	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS09070	COG1012	belongs to the aldehyde dehydrogenase family
IOD16_RS09075	COG2197	response regulator
IOD16_RS09085	COG1131	(ABC) transporter
IOD16_RS09095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IOD16_RS09110	COG2192	nodulation
IOD16_RS09115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD16_RS09120	COG0745	RESPONSE REGULATOR receiver
IOD16_RS09125	COG0656	L-ascorbic acid biosynthetic process
IOD16_RS09200	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD16_RS09225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IOD16_RS09225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IOD16_RS09240	COG1609	Transcriptional regulator
IOD16_RS09255	COG1175	transmembrane transport
IOD16_RS09260	COG1653	transport
IOD16_RS09265	COG1609	Transcriptional regulator
IOD16_RS09280	COG3458	cephalosporin-C deacetylase activity
IOD16_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS09325	COG4677	pectinesterase activity
IOD16_RS09335	COG0395	ABC-type sugar transport system, permease component
IOD16_RS09345	COG4948	Mandelate Racemase Muconate Lactonizing
IOD16_RS09365	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS09370	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS09380	COG1879	ABC-type sugar transport system periplasmic component
IOD16_RS09395	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD16_RS09400	COG1609	Transcriptional regulator
IOD16_RS09415	COG2160	L-arabinose isomerase activity
IOD16_RS09420	COG4213	ABC transporter substrate-binding protein
IOD16_RS09430	COG4214	carbohydrate transport
IOD16_RS09450	COG1846	Transcriptional regulator
IOD16_RS09450	COG1940	carbohydrate kinase activity
IOD16_RS09475	COG3537	Alpha-1,2-mannosidase
IOD16_RS09510	COG0596	Alpha beta hydrolase
IOD16_RS09520	COG3540	Alkaline phosphatase
IOD16_RS09525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IOD16_RS09530	COG1609	Transcriptional regulator
IOD16_RS09570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IOD16_RS09575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IOD16_RS09580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOD16_RS09585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOD16_RS09595	COG0254	rRNA binding
IOD16_RS09615	COG1140	nitrate reductase beta subunit
IOD16_RS09685	COG1834	amidinotransferase
IOD16_RS09695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD16_RS09720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD16_RS09730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD16_RS09730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IOD16_RS09755	COG0531	amino acid
IOD16_RS09765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD16_RS09805	COG3629	intracellular signal transduction
IOD16_RS09805	COG3903	Transcriptional regulator
IOD16_RS09825	COG1879	ABC-type sugar transport system periplasmic component
IOD16_RS09850	COG0515	serine threonine protein kinase
IOD16_RS09860	COG1335	isochorismatase
IOD16_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS09880	COG2186	Transcriptional regulator
IOD16_RS09885	COG0477	Major facilitator Superfamily
IOD16_RS09890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD16_RS09895	COG1024	Enoyl-CoA hydratase
IOD16_RS09900	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS09910	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD16_RS09915	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD16_RS09920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IOD16_RS09925	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS09930	COG1021	2,3-dihydroxybenzoate-AMP ligase
IOD16_RS09935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD16_RS09945	COG2814	Major facilitator Superfamily
IOD16_RS09960	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS09965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD16_RS09970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD16_RS09970	COG0519	Catalyzes the synthesis of GMP from XMP
IOD16_RS09980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IOD16_RS09985	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IOD16_RS10015	COG0640	Transcriptional regulator
IOD16_RS10035	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IOD16_RS10075	COG1733	regulation of RNA biosynthetic process
IOD16_RS10080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOD16_RS10100	COG0129	dihydroxy-acid dehydratase activity
IOD16_RS10155	COG3903	Transcriptional regulator
IOD16_RS10155	COG3629	intracellular signal transduction
IOD16_RS10175	COG1253	flavin adenine dinucleotide binding
IOD16_RS10180	COG0006	proline dipeptidase activity
IOD16_RS10190	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS10195	COG1309	transcriptional regulator
IOD16_RS10220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD16_RS10230	COG0667	Aldo Keto reductase
IOD16_RS10250	COG1139	Iron-sulfur cluster binding protein
IOD16_RS10255	COG0247	lactate metabolic process
IOD16_RS10265	COG0500	methyltransferase
IOD16_RS10350	COG1404	Belongs to the peptidase S8 family
IOD16_RS10390	COG0505	Belongs to the CarA family
IOD16_RS10395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IOD16_RS10410	COG2192	nodulation
IOD16_RS10420	COG1280	lysine exporter protein (LysE YggA)
IOD16_RS10425	COG3415	Transposase
IOD16_RS10425	COG2801	Transposase and inactivated derivatives
IOD16_RS10435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD16_RS10445	COG1280	lysine exporter protein (LysE YggA)
IOD16_RS10450	COG1940	carbohydrate kinase activity
IOD16_RS10455	COG1129	ABC transporter
IOD16_RS10460	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS10465	COG1879	ABC-type sugar transport system periplasmic component
IOD16_RS10485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD16_RS10515	COG4948	Mandelate Racemase Muconate Lactonizing
IOD16_RS10530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOD16_RS10560	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS10580	COG0297	glycogen (starch) synthase activity
IOD16_RS10600	COG0463	Glycosyl transferase, family 2
IOD16_RS10630	COG0515	serine threonine protein kinase
IOD16_RS10630	COG2815	serine threonine protein kinase
IOD16_RS10635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD16_RS10640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS10695	COG1609	Transcriptional regulator
IOD16_RS10715	COG2318	DinB family
IOD16_RS10720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IOD16_RS10730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOD16_RS10740	COG3629	intracellular signal transduction
IOD16_RS10740	COG3903	Transcriptional regulator
IOD16_RS10765	COG1742	UPF0060 membrane protein
IOD16_RS10770	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
IOD16_RS10790	COG1278	Cold shock
IOD16_RS10805	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD16_RS10815	COG5002	protein histidine kinase activity
IOD16_RS10815	COG0784	Response regulator, receiver
IOD16_RS10820	COG2208	phosphoserine phosphatase activity
IOD16_RS10820	COG2770	Histidine kinase
IOD16_RS10830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOD16_RS10835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD16_RS10840	COG3485	protocatechuate 3,4-dioxygenase
IOD16_RS10845	COG3485	protocatechuate 3,4-dioxygenase
IOD16_RS10855	COG0596	Alpha beta hydrolase
IOD16_RS10860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD16_RS10930	COG0300	oxidoreductase activity
IOD16_RS10935	COG2124	cytochrome p450
IOD16_RS10950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD16_RS10955	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS10970	COG2814	Major facilitator Superfamily
IOD16_RS10980	COG1132	(ABC) transporter
IOD16_RS10985	COG1132	(ABC) transporter
IOD16_RS10990	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IOD16_RS10995	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IOD16_RS11020	COG5640	endopeptidase activity
IOD16_RS11025	COG0456	acetyltransferase
IOD16_RS11025	COG1214	PFAM Peptidase M22, glycoprotease
IOD16_RS11085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD16_RS11090	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD16_RS11095	COG1120	ATPase activity
IOD16_RS11120	COG3973	AAA domain
IOD16_RS11125	COG0477	Major facilitator Superfamily
IOD16_RS11155	COG1051	belongs to the nudix hydrolase family
IOD16_RS11160	COG1051	belongs to the nudix hydrolase family
IOD16_RS11165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD16_RS11170	COG0784	Response regulator, receiver
IOD16_RS11175	COG4251	negative regulation of phosphorylation
IOD16_RS11190	COG3339	Conserved Protein
IOD16_RS11215	COG0745	RESPONSE REGULATOR receiver
IOD16_RS11285	COG3012	SEC-C Motif Domain Protein
IOD16_RS11310	COG5297	Belongs to the glycosyl hydrolase family 6
IOD16_RS11310	COG4733	cellulase activity
IOD16_RS11315	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS11320	COG1609	Transcriptional regulator
IOD16_RS11325	COG1324	tolerance protein
IOD16_RS11330	COG0247	lactate metabolic process
IOD16_RS11330	COG0277	FAD linked oxidase domain protein
IOD16_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS11340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IOD16_RS11345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IOD16_RS11360	COG5297	Belongs to the glycosyl hydrolase family 6
IOD16_RS11370	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IOD16_RS11390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD16_RS11400	COG0215	cysteine-tRNA ligase activity
IOD16_RS11415	COG1131	(ABC) transporter
IOD16_RS11420	COG3559	Exporter of polyketide antibiotics
IOD16_RS11495	COG0140	phosphoribosyl-ATP diphosphatase activity
IOD16_RS11500	COG2329	Antibiotic biosynthesis monooxygenase
IOD16_RS11525	COG0517	IMP dehydrogenase activity
IOD16_RS11525	COG1994	Peptidase M50
IOD16_RS11530	COG2197	response regulator
IOD16_RS11535	COG4585	Histidine kinase
IOD16_RS11555	COG1222	aaa ATPase
IOD16_RS11560	COG2197	response regulator
IOD16_RS11565	COG4585	Histidine kinase
IOD16_RS11570	COG1131	(ABC) transporter
IOD16_RS11585	COG3415	Transposase
IOD16_RS11585	COG2801	Transposase and inactivated derivatives
IOD16_RS11630	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IOD16_RS11635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IOD16_RS11655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD16_RS11660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD16_RS11665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD16_RS11670	COG1414	Transcriptional regulator
IOD16_RS11690	COG1597	lipid kinase activity
IOD16_RS11695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IOD16_RS11715	COG2197	response regulator
IOD16_RS11720	COG4585	Histidine kinase
IOD16_RS11775	COG4552	Acetyltransferase involved in intracellular survival and related
IOD16_RS11800	COG4977	sequence-specific DNA binding
IOD16_RS11880	COG3903	Transcriptional regulator
IOD16_RS11880	COG3629	intracellular signal transduction
IOD16_RS11885	COG3903	Transcriptional regulator
IOD16_RS11885	COG3629	intracellular signal transduction
IOD16_RS11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD16_RS11895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD16_RS11910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD16_RS11915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD16_RS11920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD16_RS11945	COG0577	efflux transmembrane transporter activity
IOD16_RS11945	COG1136	(ABC) transporter
IOD16_RS11950	COG0583	DNA-binding transcription factor activity
IOD16_RS11995	COG2423	ornithine cyclodeaminase activity
IOD16_RS12000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD16_RS12020	COG2409	Drug exporters of the RND superfamily
IOD16_RS12035	COG0475	glutathione-regulated potassium exporter activity
IOD16_RS12050	COG1316	TRANSCRIPTIONal
IOD16_RS12095	COG1846	Transcriptional regulator
IOD16_RS12110	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS12130	COG2226	methyltransferase
IOD16_RS12140	COG3251	PFAM MbtH domain protein
IOD16_RS12165	COG2357	RelA SpoT domain protein
IOD16_RS12190	COG2353	YceI-like domain
IOD16_RS12205	COG0714	Associated with various cellular activities
IOD16_RS12220	COG2815	serine threonine protein kinase
IOD16_RS12220	COG0515	serine threonine protein kinase
IOD16_RS12240	COG1609	Transcriptional regulator
IOD16_RS12255	COG0395	ABC-type sugar transport system, permease component
IOD16_RS12260	COG4209	transmembrane transport
IOD16_RS12305	COG1396	sequence-specific DNA binding
IOD16_RS12310	COG0740	serine-type endopeptidase activity
IOD16_RS12315	COG0740	serine-type endopeptidase activity
IOD16_RS12330	COG0516	GMP reductase activity
IOD16_RS12330	COG0517	IMP dehydrogenase activity
IOD16_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS12355	COG0583	DNA-binding transcription factor activity
IOD16_RS12385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD16_RS12400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IOD16_RS12405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IOD16_RS12410	COG2080	2 iron, 2 sulfur cluster binding
IOD16_RS12420	COG3401	FG-GAP repeat protein
IOD16_RS12430	COG0477	Major facilitator Superfamily
IOD16_RS12450	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS12475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD16_RS12480	COG3467	pyridoxamine 5'-phosphate
IOD16_RS12485	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IOD16_RS12485	COG0778	Nitroreductase
IOD16_RS12500	COG0326	Molecular chaperone. Has ATPase activity
IOD16_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS12520	COG0477	Major facilitator Superfamily
IOD16_RS12530	COG1414	Transcriptional regulator
IOD16_RS12565	COG0135	phosphoribosylanthranilate isomerase activity
IOD16_RS12570	COG2040	homocysteine
IOD16_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS12590	COG0477	Major facilitator Superfamily
IOD16_RS12635	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IOD16_RS12650	COG1175	transmembrane transport
IOD16_RS12655	COG0395	ABC-type sugar transport system, permease component
IOD16_RS12700	COG3415	Transposase
IOD16_RS12700	COG2801	Transposase and inactivated derivatives
IOD16_RS12725	COG2205	protein histidine kinase activity
IOD16_RS12730	COG0745	RESPONSE REGULATOR receiver
IOD16_RS12745	COG1131	(ABC) transporter
IOD16_RS12750	COG0367	asparagine synthase
IOD16_RS12755	COG1609	Transcriptional regulator
IOD16_RS12780	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS12785	COG0028	Belongs to the TPP enzyme family
IOD16_RS12790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD16_RS12805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS12820	COG2175	clavaminate synthase activity
IOD16_RS12825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IOD16_RS12865	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS12870	COG2030	dehydratase
IOD16_RS12875	COG2030	dehydratase
IOD16_RS12885	COG0640	Transcriptional regulator
IOD16_RS12900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD16_RS12920	COG3251	PFAM MbtH domain protein
IOD16_RS12925	COG0154	amidase activity
IOD16_RS12935	COG0069	glutamate synthase activity
IOD16_RS12940	COG0017	Asparaginyl-tRNA synthetase
IOD16_RS12965	COG3629	intracellular signal transduction
IOD16_RS12965	COG3903	Transcriptional regulator
IOD16_RS13015	COG1940	carbohydrate kinase activity
IOD16_RS13015	COG1846	Transcriptional regulator
IOD16_RS13035	COG1595	DNA-templated transcription, initiation
IOD16_RS13040	COG1252	NADH dehydrogenase
IOD16_RS13105	COG4770	biotin carboxylase activity
IOD16_RS13110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS13125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD16_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS13150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD16_RS13160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS13165	COG0477	Major facilitator Superfamily
IOD16_RS13175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS13180	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS13190	COG2226	methyltransferase
IOD16_RS13190	COG2867	negative regulation of translational initiation
IOD16_RS13205	COG2188	Transcriptional regulator
IOD16_RS13230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IOD16_RS13235	COG3866	Pectate lyase
IOD16_RS13260	COG0738	Major facilitator superfamily
IOD16_RS13265	COG1349	DNA-binding transcription factor activity
IOD16_RS13275	COG2132	Multicopper oxidase
IOD16_RS13295	COG2755	lipolytic protein G-D-S-L family
IOD16_RS13300	COG2986	histidine ammonia-lyase
IOD16_RS13325	COG2226	methyltransferase
IOD16_RS13345	COG3401	FG-GAP repeat protein
IOD16_RS13370	COG0583	DNA-binding transcription factor activity
IOD16_RS13390	COG1609	Transcriptional regulator
IOD16_RS13405	COG0395	ABC-type sugar transport system, permease component
IOD16_RS13415	COG1609	Transcriptional regulator
IOD16_RS13420	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS13425	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS13440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD16_RS13475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS13490	COG2124	cytochrome p450
IOD16_RS13515	COG2814	Major facilitator Superfamily
IOD16_RS13520	COG2124	cytochrome p450
IOD16_RS13525	COG2124	cytochrome p450
IOD16_RS13545	COG3509	depolymerase
IOD16_RS13570	COG1609	Transcriptional regulator
IOD16_RS13580	COG2755	lipolytic protein G-D-S-L family
IOD16_RS13600	COG1132	(ABC) transporter
IOD16_RS13645	COG4585	Histidine kinase
IOD16_RS13680	COG0604	alcohol dehydrogenase
IOD16_RS13680	COG3321	synthase
IOD16_RS13720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD16_RS13725	COG4521	taurine ABC transporter
IOD16_RS13735	COG2175	clavaminate synthase activity
IOD16_RS13745	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD16_RS13765	COG1070	Carbohydrate kinase
IOD16_RS13770	COG3347	Dehydrogenase
IOD16_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS13775	COG4952	isomerase
IOD16_RS13780	COG1609	Transcriptional regulator
IOD16_RS13785	COG1129	ABC transporter
IOD16_RS13790	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS13805	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS13820	COG0673	inositol 2-dehydrogenase activity
IOD16_RS13825	COG1129	ABC transporter
IOD16_RS13830	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS13835	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS13860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IOD16_RS13890	COG2409	Drug exporters of the RND superfamily
IOD16_RS13925	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IOD16_RS13940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD16_RS13945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD16_RS13950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IOD16_RS13980	COG0439	Biotin carboxylase
IOD16_RS14000	COG2207	Transcriptional regulator
IOD16_RS14000	COG3708	Transcriptional regulator
IOD16_RS14010	COG3250	beta-galactosidase activity
IOD16_RS14020	COG0148	phosphopyruvate hydratase activity
IOD16_RS14025	COG0589	response to stress
IOD16_RS14045	COG1140	nitrate reductase beta subunit
IOD16_RS14065	COG0488	(ABC) transporter
IOD16_RS14115	COG3629	intracellular signal transduction
IOD16_RS14115	COG3903	Transcriptional regulator
IOD16_RS14175	COG0784	Response regulator, receiver
IOD16_RS14175	COG2205	protein histidine kinase activity
IOD16_RS14185	COG2172	sigma factor antagonist activity
IOD16_RS14190	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD16_RS14195	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD16_RS14235	COG2267	carboxylic ester hydrolase activity
IOD16_RS14240	COG0596	Alpha beta hydrolase
IOD16_RS14260	COG0596	Alpha beta hydrolase
IOD16_RS14265	COG1215	transferase activity, transferring glycosyl groups
IOD16_RS14270	COG5650	phosphatidylinositol metabolic process
IOD16_RS14275	COG2814	Major facilitator Superfamily
IOD16_RS14290	COG3537	Alpha-1,2-mannosidase
IOD16_RS14305	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD16_RS14310	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD16_RS14315	COG1414	Transcriptional regulator
IOD16_RS14335	COG2301	Belongs to the HpcH HpaI aldolase family
IOD16_RS14340	COG1414	Transcriptional regulator
IOD16_RS14345	COG1902	pentaerythritol trinitrate reductase activity
IOD16_RS14375	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS14380	COG0601	transmembrane transport
IOD16_RS14390	COG0444	Belongs to the ABC transporter superfamily
IOD16_RS14395	COG4608	Belongs to the ABC transporter superfamily
IOD16_RS14405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD16_RS14410	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IOD16_RS14420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IOD16_RS14440	COG1132	(ABC) transporter
IOD16_RS14450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD16_RS14480	COG0204	Acyl-transferase
IOD16_RS14480	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS14490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD16_RS14510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD16_RS14520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS14560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOD16_RS14565	COG0022	dehydrogenase e1 component
IOD16_RS14570	COG0657	acetylesterase activity
IOD16_RS14600	COG0604	alcohol dehydrogenase
IOD16_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS14600	COG3321	synthase
IOD16_RS14645	COG1609	Transcriptional regulator
IOD16_RS14650	COG0366	Alpha amylase catalytic
IOD16_RS14660	COG1175	transmembrane transport
IOD16_RS14665	COG0395	ABC-type sugar transport system, permease component
IOD16_RS14670	COG3250	beta-galactosidase activity
IOD16_RS14675	COG0366	Alpha amylase catalytic
IOD16_RS14785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IOD16_RS14790	COG2986	histidine ammonia-lyase
IOD16_RS14800	COG0367	asparagine synthase
IOD16_RS14815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS14910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOD16_RS14920	COG0598	Magnesium transport protein CorA
IOD16_RS14930	COG5504	Zn-dependent protease
IOD16_RS14935	COG1132	(ABC) transporter
IOD16_RS14945	COG1309	transcriptional regulator
IOD16_RS14960	COG0640	Transcriptional regulator
IOD16_RS14965	COG0246	Mannitol dehydrogenase
IOD16_RS14970	COG0477	Major facilitator Superfamily
IOD16_RS14980	COG1414	Transcriptional regulator
IOD16_RS14990	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IOD16_RS15015	COG4941	Belongs to the sigma-70 factor family
IOD16_RS15020	COG3795	YCII-related domain
IOD16_RS15095	COG0395	ABC-type sugar transport system, permease component
IOD16_RS15100	COG4209	transmembrane transport
IOD16_RS15140	COG1653	transport
IOD16_RS15145	COG0395	ABC-type sugar transport system, permease component
IOD16_RS15150	COG4209	transmembrane transport
IOD16_RS15155	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS15160	COG1609	Transcriptional regulator
IOD16_RS15165	COG3415	Transposase
IOD16_RS15165	COG2801	Transposase and inactivated derivatives
IOD16_RS15170	COG0435	Glutathione S-transferase
IOD16_RS15180	COG1082	Xylose isomerase domain protein TIM barrel
IOD16_RS15240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IOD16_RS15255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IOD16_RS15260	COG3281	Trehalose synthase
IOD16_RS15270	COG0366	Alpha amylase catalytic
IOD16_RS15280	COG0028	Belongs to the TPP enzyme family
IOD16_RS15285	COG0693	protein deglycase activity
IOD16_RS15310	COG2770	Histidine kinase
IOD16_RS15310	COG2208	phosphoserine phosphatase activity
IOD16_RS15320	COG2814	Major facilitator Superfamily
IOD16_RS15325	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS15390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD16_RS15390	COG1703	isobutyryl-CoA mutase activity
IOD16_RS15390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD16_RS15420	COG0395	ABC-type sugar transport system, permease component
IOD16_RS15455	COG0187	DNA topoisomerase II activity
IOD16_RS15455	COG1372	Participates in initiation and elongation during chromosome replication
IOD16_RS15460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD16_RS15460	COG1372	Participates in initiation and elongation during chromosome replication
IOD16_RS15460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD16_RS15460	COG1372	Participates in initiation and elongation during chromosome replication
IOD16_RS15470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS15490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IOD16_RS15510	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IOD16_RS15510	COG1672	PFAM Archaeal ATPase
IOD16_RS15515	COG1309	transcriptional regulator
IOD16_RS15530	COG4124	Belongs to the glycosyl hydrolase 26 family
IOD16_RS15535	COG5001	Diguanylate cyclase
IOD16_RS15565	COG2226	methyltransferase
IOD16_RS15580	COG3285	dna ligase
IOD16_RS15580	COG1793	dna ligase
IOD16_RS15610	COG3401	FG-GAP repeat protein
IOD16_RS15620	COG3254	rhamnose metabolic process
IOD16_RS15625	COG3401	FG-GAP repeat protein
IOD16_RS15635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IOD16_RS15650	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IOD16_RS15650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS15690	COG1335	isochorismatase
IOD16_RS15695	COG0309	Hydrogenase expression formation protein (HypE)
IOD16_RS15700	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IOD16_RS15720	COG0483	inositol monophosphate 1-phosphatase activity
IOD16_RS15725	COG2814	Major facilitator Superfamily
IOD16_RS15730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IOD16_RS15740	COG2124	cytochrome p450
IOD16_RS15745	COG2197	response regulator
IOD16_RS15750	COG4585	Histidine kinase
IOD16_RS15770	COG1874	Beta-galactosidase
IOD16_RS15770	COG0366	Alpha amylase catalytic
IOD16_RS15780	COG1609	Transcriptional regulator
IOD16_RS15785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD16_RS15825	COG4565	transcriptional regulatory protein
IOD16_RS15830	COG3290	protein histidine kinase activity
IOD16_RS15850	COG0604	alcohol dehydrogenase
IOD16_RS15855	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IOD16_RS15860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IOD16_RS15870	COG1607	acyl-coa hydrolase
IOD16_RS15895	COG0463	Glycosyl transferase, family 2
IOD16_RS15915	COG1435	thymidine kinase activity
IOD16_RS15935	COG0584	glycerophosphoryl diester phosphodiesterase
IOD16_RS15955	COG3467	pyridoxamine 5'-phosphate
IOD16_RS15960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IOD16_RS15965	COG3285	dna ligase
IOD16_RS15965	COG1793	dna ligase
IOD16_RS15975	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IOD16_RS15980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IOD16_RS16010	COG2267	carboxylic ester hydrolase activity
IOD16_RS16015	COG2264	protein methyltransferase activity
IOD16_RS16020	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS16105	COG1619	proteins homologs of microcin C7 resistance protein MccF
IOD16_RS16130	COG1011	Hydrolase
IOD16_RS16140	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS16145	COG1733	regulation of RNA biosynthetic process
IOD16_RS16160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD16_RS16165	COG0601	transmembrane transport
IOD16_RS16170	COG4166	transmembrane transport
IOD16_RS16175	COG2362	D-Aminopeptidase
IOD16_RS16180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD16_RS16200	COG1660	Displays ATPase and GTPase activities
IOD16_RS16210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD16_RS16300	COG0596	Alpha beta hydrolase
IOD16_RS16310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS16315	COG1846	Transcriptional regulator
IOD16_RS16320	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IOD16_RS16345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD16_RS16355	COG0515	serine threonine protein kinase
IOD16_RS16375	COG0702	epimerase
IOD16_RS16380	COG0702	epimerase
IOD16_RS16385	COG1846	Transcriptional regulator
IOD16_RS16410	COG1643	Atp-dependent helicase
IOD16_RS16425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS16475	COG1968	undecaprenyl-diphosphatase activity
IOD16_RS16480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS16485	COG0667	Aldo Keto reductase
IOD16_RS16510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD16_RS16545	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD16_RS16550	COG1309	transcriptional regulator
IOD16_RS16555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOD16_RS16565	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IOD16_RS16580	COG2124	cytochrome p450
IOD16_RS16600	COG3845	ABC transporter
IOD16_RS16620	COG2814	Major facilitator Superfamily
IOD16_RS16670	COG0277	FAD linked oxidase domain protein
IOD16_RS16690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD16_RS16700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD16_RS16735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD16_RS16770	COG2356	endonuclease I
IOD16_RS16785	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD16_RS16800	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD16_RS16805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD16_RS16805	COG0723	plastoquinol--plastocyanin reductase activity
IOD16_RS16825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD16_RS16835	COG0501	Belongs to the peptidase M48B family
IOD16_RS16850	COG2188	Transcriptional regulator
IOD16_RS16855	COG2182	Extracellular solute-binding protein
IOD16_RS16860	COG1175	transmembrane transport
IOD16_RS16865	COG0395	ABC-type sugar transport system, permease component
IOD16_RS16875	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IOD16_RS16880	COG2211	Major facilitator Superfamily
IOD16_RS16885	COG0076	glutamate decarboxylase activity
IOD16_RS16895	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS16930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS16940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS16945	COG2814	Major facilitator Superfamily
IOD16_RS17000	COG1280	lysine exporter protein (LysE YggA)
IOD16_RS17025	COG0640	Transcriptional regulator
IOD16_RS17035	COG0477	Major facilitator Superfamily
IOD16_RS17070	COG3866	Pectate lyase
IOD16_RS17080	COG3866	Pectate lyase
IOD16_RS17150	COG3706	GGDEF domain
IOD16_RS17160	COG5001	Diguanylate cyclase
IOD16_RS17170	COG1408	metallophosphoesterase
IOD16_RS17190	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOD16_RS17230	COG0018	arginyl-trna synthetase
IOD16_RS17240	COG0366	Alpha amylase catalytic
IOD16_RS17245	COG0745	RESPONSE REGULATOR receiver
IOD16_RS17250	COG0456	acetyltransferase
IOD16_RS17270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOD16_RS17300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS17305	COG0667	Aldo Keto reductase
IOD16_RS17315	COG0604	alcohol dehydrogenase
IOD16_RS17345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS17365	COG4221	oxidoreductase activity
IOD16_RS17380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS17385	COG1609	Transcriptional regulator
IOD16_RS17395	COG1501	Belongs to the glycosyl hydrolase 31 family
IOD16_RS17400	COG0395	ABC-type sugar transport system, permease component
IOD16_RS17435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD16_RS17460	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS17465	COG3537	Alpha-1,2-mannosidase
IOD16_RS17470	COG1819	glycosyl
IOD16_RS17480	COG1473	amidohydrolase
IOD16_RS17505	COG1819	glycosyl
IOD16_RS17645	COG0833	amino acid
IOD16_RS17650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IOD16_RS17650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD16_RS17655	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS17695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOD16_RS17740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD16_RS17750	COG3321	synthase
IOD16_RS17750	COG0604	alcohol dehydrogenase
IOD16_RS17790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD16_RS17820	COG2124	cytochrome p450
IOD16_RS17830	COG2084	Dehydrogenase
IOD16_RS17845	COG0477	Major facilitator Superfamily
IOD16_RS17885	COG0515	serine threonine protein kinase
IOD16_RS17885	COG2815	serine threonine protein kinase
IOD16_RS17890	COG4257	antibiotic catabolic process
IOD16_RS17930	COG4585	Histidine kinase
IOD16_RS17935	COG2197	response regulator
IOD16_RS17945	COG1136	(ABC) transporter
IOD16_RS17945	COG0577	efflux transmembrane transporter activity
IOD16_RS17955	COG0604	alcohol dehydrogenase
IOD16_RS17955	COG3321	synthase
IOD16_RS17965	COG1509	lysine 2,3-aminomutase activity
IOD16_RS17970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD16_RS17980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS17985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS17995	COG2267	carboxylic ester hydrolase activity
IOD16_RS18000	COG0604	alcohol dehydrogenase
IOD16_RS18000	COG3321	synthase
IOD16_RS18015	COG0604	alcohol dehydrogenase
IOD16_RS18015	COG3321	synthase
IOD16_RS18020	COG0477	Major facilitator Superfamily
IOD16_RS18045	COG3537	Alpha-1,2-mannosidase
IOD16_RS18060	COG1309	transcriptional regulator
IOD16_RS18065	COG0640	Transcriptional regulator
IOD16_RS18070	COG0346	lactoylglutathione lyase activity
IOD16_RS18085	COG0745	RESPONSE REGULATOR receiver
IOD16_RS18115	COG2319	Wd-40 repeat
IOD16_RS18115	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD16_RS18130	COG1216	Glycosyl transferase, family 2
IOD16_RS18150	COG1757	Na H antiporter
IOD16_RS18160	COG2235	arginine
IOD16_RS18285	COG1674	ftsk spoiiie
IOD16_RS18360	COG3903	Transcriptional regulator
IOD16_RS18360	COG3629	intracellular signal transduction
IOD16_RS18485	COG1882	Formate acetyltransferase
IOD16_RS18490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD16_RS18495	COG0659	secondary active sulfate transmembrane transporter activity
IOD16_RS18505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOD16_RS18510	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IOD16_RS18630	COG0517	IMP dehydrogenase activity
IOD16_RS18635	COG0589	response to stress
IOD16_RS18650	COG0589	response to stress
IOD16_RS18690	COG0604	alcohol dehydrogenase
IOD16_RS18695	COG0702	epimerase
IOD16_RS18765	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD16_RS18800	COG1959	2 iron, 2 sulfur cluster binding
IOD16_RS18825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD16_RS18830	COG1982	Orn Lys Arg decarboxylase major
IOD16_RS18845	COG4585	Histidine kinase
IOD16_RS18850	COG2197	response regulator
IOD16_RS18870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD16_RS18905	COG0006	proline dipeptidase activity
IOD16_RS18910	COG1802	Transcriptional regulator
IOD16_RS18915	COG3938	Belongs to the proline racemase family
IOD16_RS18925	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD16_RS18935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD16_RS18955	COG1609	Transcriptional regulator
IOD16_RS18965	COG0395	ABC-type sugar transport system, permease component
IOD16_RS18970	COG1175	transmembrane transport
IOD16_RS19025	COG1131	(ABC) transporter
IOD16_RS19055	COG0133	tryptophan synthase activity
IOD16_RS19060	COG0159	tryptophan synthase activity
IOD16_RS19065	COG2188	Transcriptional regulator
IOD16_RS19080	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IOD16_RS19085	COG0714	Associated with various cellular activities
IOD16_RS19130	COG0142	geranyltranstransferase activity
IOD16_RS19150	COG1082	Xylose isomerase domain protein TIM barrel
IOD16_RS19165	COG3321	synthase
IOD16_RS19165	COG3321	synthase
IOD16_RS19165	COG0604	alcohol dehydrogenase
IOD16_RS19165	COG0604	alcohol dehydrogenase
IOD16_RS19240	COG0154	amidase activity
IOD16_RS19275	COG0076	glutamate decarboxylase activity
IOD16_RS19285	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IOD16_RS19300	COG2226	methyltransferase
IOD16_RS19340	COG1131	(ABC) transporter
IOD16_RS19365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD16_RS19370	COG0601	transmembrane transport
IOD16_RS19390	COG4941	Belongs to the sigma-70 factor family
IOD16_RS19435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD16_RS19440	COG1121	(ABC) transporter
IOD16_RS19450	COG0803	Belongs to the bacterial solute-binding protein 9 family
IOD16_RS19475	COG3903	Transcriptional regulator
IOD16_RS19475	COG3629	intracellular signal transduction
IOD16_RS19505	COG1131	(ABC) transporter
IOD16_RS19515	COG4585	Histidine kinase
IOD16_RS19520	COG2197	response regulator
IOD16_RS19565	COG1595	DNA-templated transcription, initiation
IOD16_RS19575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD16_RS19595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD16_RS19600	COG3848	Pyruvate phosphate dikinase
IOD16_RS19600	COG0574	Belongs to the PEP-utilizing enzyme family
IOD16_RS19605	COG2801	Transposase and inactivated derivatives
IOD16_RS19605	COG3415	Transposase
IOD16_RS19610	COG3852	Histidine kinase
IOD16_RS19615	COG0492	ferredoxin-NADP+ reductase activity
IOD16_RS19615	COG3118	belongs to the thioredoxin family
IOD16_RS19620	COG3903	Transcriptional regulator
IOD16_RS19620	COG3629	intracellular signal transduction
IOD16_RS19640	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS19655	COG4585	Histidine kinase
IOD16_RS19685	COG5297	Belongs to the glycosyl hydrolase family 6
IOD16_RS19685	COG4733	cellulase activity
IOD16_RS19690	COG1595	DNA-templated transcription, initiation
IOD16_RS19700	COG3285	dna ligase
IOD16_RS19700	COG1793	dna ligase
IOD16_RS19725	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD16_RS19725	COG1902	pentaerythritol trinitrate reductase activity
IOD16_RS19740	COG1404	Belongs to the peptidase S8 family
IOD16_RS19800	COG1234	tRNA 3'-trailer cleavage
IOD16_RS19830	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IOD16_RS19835	COG1733	regulation of RNA biosynthetic process
IOD16_RS19845	COG2267	carboxylic ester hydrolase activity
IOD16_RS19850	COG0542	response to heat
IOD16_RS19855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD16_RS19875	COG2318	DinB family
IOD16_RS19880	COG3285	dna ligase
IOD16_RS19880	COG1793	dna ligase
IOD16_RS19905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IOD16_RS19915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IOD16_RS19920	COG0659	secondary active sulfate transmembrane transporter activity
IOD16_RS19945	COG0515	serine threonine protein kinase
IOD16_RS19970	COG3509	depolymerase
IOD16_RS19970	COG3693	PFAM glycoside hydrolase, family 10
IOD16_RS19980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS20020	COG0583	DNA-binding transcription factor activity
IOD16_RS20025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD16_RS20045	COG0596	Alpha beta hydrolase
IOD16_RS20050	COG3866	Pectate lyase
IOD16_RS20080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IOD16_RS20120	COG4585	Histidine kinase
IOD16_RS20125	COG2197	response regulator
IOD16_RS20135	COG3835	regulator
IOD16_RS20155	COG0583	DNA-binding transcription factor activity
IOD16_RS20180	COG2367	Beta-lactamase
IOD16_RS20190	COG1063	alcohol dehydrogenase
IOD16_RS20200	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS20215	COG0583	DNA-binding transcription factor activity
IOD16_RS20220	COG1278	Cold shock
IOD16_RS20225	COG2027	D-alanyl-D-alanine carboxypeptidase
IOD16_RS20240	COG3265	gluconokinase activity
IOD16_RS20245	COG2610	gluconate transmembrane transporter activity
IOD16_RS20255	COG0129	dihydroxy-acid dehydratase activity
IOD16_RS20270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IOD16_RS20275	COG2409	Drug exporters of the RND superfamily
IOD16_RS20300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD16_RS20320	COG3693	PFAM glycoside hydrolase, family 10
IOD16_RS20330	COG0243	molybdopterin cofactor binding
IOD16_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS20355	COG1132	(ABC) transporter
IOD16_RS20365	COG1216	Glycosyl transferase, family 2
IOD16_RS20385	COG0488	(ABC) transporter
IOD16_RS20390	COG0488	(ABC) transporter
IOD16_RS20415	COG1174	glycine betaine transport
IOD16_RS20425	COG1174	glycine betaine transport
IOD16_RS20445	COG2197	response regulator
IOD16_RS20450	COG3903	Transcriptional regulator
IOD16_RS20450	COG3629	intracellular signal transduction
IOD16_RS20455	COG3903	Transcriptional regulator
IOD16_RS20455	COG3629	intracellular signal transduction
IOD16_RS20475	COG2124	cytochrome p450
IOD16_RS20505	COG0745	RESPONSE REGULATOR receiver
IOD16_RS20510	COG2205	protein histidine kinase activity
IOD16_RS20530	COG1609	Transcriptional regulator
IOD16_RS20545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS20585	COG0745	RESPONSE REGULATOR receiver
IOD16_RS20595	COG2986	histidine ammonia-lyase
IOD16_RS20610	COG0492	ferredoxin-NADP+ reductase activity
IOD16_RS20625	COG0475	glutathione-regulated potassium exporter activity
IOD16_RS20635	COG3973	AAA domain
IOD16_RS20640	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD16_RS20645	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IOD16_RS20655	COG0395	ABC-type sugar transport system, permease component
IOD16_RS20660	COG1175	transmembrane transport
IOD16_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS20685	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IOD16_RS20690	COG1609	Transcriptional regulator
IOD16_RS20725	COG3629	intracellular signal transduction
IOD16_RS20725	COG3903	Transcriptional regulator
IOD16_RS20730	COG3693	PFAM glycoside hydrolase, family 10
IOD16_RS20740	COG0395	ABC-type sugar transport system, permease component
IOD16_RS20745	COG1653	transport
IOD16_RS20755	COG1609	Transcriptional regulator
IOD16_RS20775	COG2319	Wd-40 repeat
IOD16_RS20775	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD16_RS20785	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS20825	COG3629	intracellular signal transduction
IOD16_RS20825	COG3903	Transcriptional regulator
IOD16_RS20830	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS20835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD16_RS20855	COG2197	response regulator
IOD16_RS20860	COG4585	Histidine kinase
IOD16_RS20875	COG1335	isochorismatase
IOD16_RS20885	COG0277	FAD linked oxidase domain protein
IOD16_RS20915	COG0604	alcohol dehydrogenase
IOD16_RS20945	COG0009	L-threonylcarbamoyladenylate synthase
IOD16_RS20955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD16_RS20955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD16_RS20975	COG1136	(ABC) transporter
IOD16_RS20980	COG1136	(ABC) transporter
IOD16_RS20980	COG0577	efflux transmembrane transporter activity
IOD16_RS21000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD16_RS21005	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD16_RS21020	COG1522	sequence-specific DNA binding
IOD16_RS21025	COG2340	Cysteine-rich secretory protein family
IOD16_RS21030	COG2205	protein histidine kinase activity
IOD16_RS21045	COG2755	lipolytic protein G-D-S-L family
IOD16_RS21070	COG0067	glutamate synthase
IOD16_RS21070	COG0069	glutamate synthase activity
IOD16_RS21070	COG0070	glutamate synthase
IOD16_RS21080	COG1846	Transcriptional regulator
IOD16_RS21085	COG3447	MASE1 domain protein
IOD16_RS21085	COG5002	protein histidine kinase activity
IOD16_RS21085	COG5001	Diguanylate cyclase
IOD16_RS21090	COG4213	ABC transporter substrate-binding protein
IOD16_RS21095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD16_RS21125	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD16_RS21130	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IOD16_RS21135	COG0515	serine threonine protein kinase
IOD16_RS21135	COG2815	serine threonine protein kinase
IOD16_RS21145	COG2326	polyphosphate kinase activity
IOD16_RS21160	COG1609	Transcriptional regulator
IOD16_RS21190	COG2197	response regulator
IOD16_RS21200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD16_RS21205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD16_RS21295	COG2304	oxidoreductase activity
IOD16_RS21305	COG0714	Associated with various cellular activities
IOD16_RS21310	COG0746	molybdenum cofactor guanylyltransferase activity
IOD16_RS21315	COG5001	Diguanylate cyclase
IOD16_RS21315	COG3300	MHYT domain
IOD16_RS21320	COG3447	MASE1 domain protein
IOD16_RS21320	COG5001	Diguanylate cyclase
IOD16_RS21320	COG5002	protein histidine kinase activity
IOD16_RS21340	COG0791	NLP P60 protein
IOD16_RS21340	COG3883	PFAM NLP P60 protein
IOD16_RS21355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOD16_RS21375	COG0110	maltose O-acetyltransferase activity
IOD16_RS21390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IOD16_RS21420	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS21425	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IOD16_RS21430	COG0121	glutamine amidotransferase
IOD16_RS21435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOD16_RS21440	COG3572	ergothioneine biosynthetic process
IOD16_RS21445	COG3250	beta-galactosidase activity
IOD16_RS21450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOD16_RS21465	COG1309	transcriptional regulator
IOD16_RS21470	COG2124	cytochrome p450
IOD16_RS21490	COG1733	regulation of RNA biosynthetic process
IOD16_RS21495	COG0702	epimerase
IOD16_RS21500	COG3104	oligopeptide transport
IOD16_RS21515	COG0217	transcriptional regulatory protein
IOD16_RS21525	COG0626	cystathionine gamma-synthase activity
IOD16_RS21530	COG1522	sequence-specific DNA binding
IOD16_RS21550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOD16_RS21555	COG1396	sequence-specific DNA binding
IOD16_RS21560	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IOD16_RS21580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD16_RS21595	COG3629	intracellular signal transduction
IOD16_RS21595	COG3903	Transcriptional regulator
IOD16_RS21605	COG0583	DNA-binding transcription factor activity
IOD16_RS21610	COG1953	Uracil, thiamine, allantoin
IOD16_RS21620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IOD16_RS21655	COG1051	belongs to the nudix hydrolase family
IOD16_RS21660	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS21665	COG1560	Kdo2-lipid A biosynthetic process
IOD16_RS21670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOD16_RS21690	COG1024	Enoyl-CoA hydratase
IOD16_RS21710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IOD16_RS21720	COG2186	Transcriptional regulator
IOD16_RS21735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IOD16_RS21745	COG0531	amino acid
IOD16_RS21780	COG3033	Beta-eliminating lyase
IOD16_RS21820	COG3835	regulator
IOD16_RS21845	COG0590	tRNA wobble adenosine to inosine editing
IOD16_RS21855	COG4585	Histidine kinase
IOD16_RS21865	COG1131	(ABC) transporter
IOD16_RS21890	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IOD16_RS21940	COG0137	argininosuccinate synthase activity
IOD16_RS21955	COG1690	Belongs to the RtcB family
IOD16_RS21960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOD16_RS21990	COG1309	transcriptional regulator
IOD16_RS22020	COG2197	response regulator
IOD16_RS22035	COG5001	Diguanylate cyclase
IOD16_RS22045	COG2124	cytochrome p450
IOD16_RS22070	COG0745	RESPONSE REGULATOR receiver
IOD16_RS22075	COG2205	protein histidine kinase activity
IOD16_RS22080	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IOD16_RS22085	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD16_RS22090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD16_RS22135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS22140	COG0515	serine threonine protein kinase
IOD16_RS22165	COG1131	(ABC) transporter
IOD16_RS22175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS22180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS22185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD16_RS22185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD16_RS22185	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS22185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD16_RS22185	COG3321	synthase
IOD16_RS22190	COG4221	oxidoreductase activity
IOD16_RS22190	COG3321	synthase
IOD16_RS22190	COG0300	oxidoreductase activity
IOD16_RS22190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD16_RS22205	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS22220	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD16_RS22225	COG2264	protein methyltransferase activity
IOD16_RS22240	COG1309	transcriptional regulator
IOD16_RS22245	COG0644	oxidoreductase
IOD16_RS22250	COG0156	8-amino-7-oxononanoate synthase activity
IOD16_RS22255	COG1609	Transcriptional regulator
IOD16_RS22265	COG3509	depolymerase
IOD16_RS22275	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS22295	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS22295	COG3693	PFAM glycoside hydrolase, family 10
IOD16_RS22295	COG2382	esterase
IOD16_RS22310	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS22330	COG0673	inositol 2-dehydrogenase activity
IOD16_RS22335	COG1879	ABC-type sugar transport system periplasmic component
IOD16_RS22340	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS22345	COG1129	ABC transporter
IOD16_RS22350	COG1940	carbohydrate kinase activity
IOD16_RS22350	COG1846	Transcriptional regulator
IOD16_RS22365	COG0693	protein deglycase activity
IOD16_RS22385	COG5297	Belongs to the glycosyl hydrolase family 6
IOD16_RS22390	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS22395	COG3345	alpha-galactosidase
IOD16_RS22430	COG4948	Mandelate Racemase Muconate Lactonizing
IOD16_RS22435	COG0395	ABC-type sugar transport system, permease component
IOD16_RS22455	COG1609	Transcriptional regulator
IOD16_RS22475	COG0109	protoheme IX farnesyltransferase activity
IOD16_RS22510	COG3875	lactate racemase activity
IOD16_RS22515	COG2186	Transcriptional regulator
IOD16_RS22535	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS22545	COG4209	transmembrane transport
IOD16_RS22550	COG0395	ABC-type sugar transport system, permease component
IOD16_RS22555	COG1609	Transcriptional regulator
IOD16_RS22570	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS22580	COG4733	cellulase activity
IOD16_RS22580	COG5297	Belongs to the glycosyl hydrolase family 6
IOD16_RS22590	COG3458	cephalosporin-C deacetylase activity
IOD16_RS22595	COG3345	alpha-galactosidase
IOD16_RS22600	COG1606	tRNA processing
IOD16_RS22605	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IOD16_RS22610	COG1691	(AIR) carboxylase
IOD16_RS22620	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD16_RS22630	COG4948	Mandelate Racemase Muconate Lactonizing
IOD16_RS22670	COG0673	inositol 2-dehydrogenase activity
IOD16_RS22715	COG0789	Transcriptional regulator
IOD16_RS22740	COG0142	geranyltranstransferase activity
IOD16_RS22825	COG0596	Alpha beta hydrolase
IOD16_RS22830	COG2770	Histidine kinase
IOD16_RS22830	COG2208	phosphoserine phosphatase activity
IOD16_RS22840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD16_RS22860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD16_RS22870	COG1120	ATPase activity
IOD16_RS22905	COG2197	response regulator
IOD16_RS22925	COG0589	response to stress
IOD16_RS22945	COG0651	ATP synthesis coupled electron transport
IOD16_RS22950	COG1006	Multisubunit Na H antiporter MnhC subunit
IOD16_RS22960	COG2111	Na H antiporter
IOD16_RS22960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD16_RS22990	COG3604	Transcriptional regulator
IOD16_RS22995	COG2261	transglycosylase associated protein
IOD16_RS23005	COG2018	Roadblock/LC7 domain
IOD16_RS23025	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD16_RS23085	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS23095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD16_RS23140	COG3629	intracellular signal transduction
IOD16_RS23140	COG3903	Transcriptional regulator
IOD16_RS23185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOD16_RS23190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD16_RS23195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS23220	COG2175	clavaminate synthase activity
IOD16_RS23265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD16_RS23275	COG2319	Wd-40 repeat
IOD16_RS23275	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD16_RS23285	COG1653	transport
IOD16_RS23305	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IOD16_RS23385	COG0395	ABC-type sugar transport system, permease component
IOD16_RS23395	COG1136	(ABC) transporter
IOD16_RS23400	COG0577	efflux transmembrane transporter activity
IOD16_RS23465	COG0477	Major facilitator Superfamily
IOD16_RS23480	COG0601	transmembrane transport
IOD16_RS23485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD16_RS23545	COG2843	Capsule synthesis protein
IOD16_RS23550	COG0655	NAD(P)H dehydrogenase (quinone) activity
IOD16_RS23570	COG3903	Transcriptional regulator
IOD16_RS23570	COG3629	intracellular signal transduction
IOD16_RS23585	COG0577	efflux transmembrane transporter activity
IOD16_RS23635	COG1597	lipid kinase activity
IOD16_RS23665	COG2860	membrane
IOD16_RS23680	COG4585	Histidine kinase
IOD16_RS23685	COG2197	response regulator
IOD16_RS23695	COG1136	(ABC) transporter
IOD16_RS23745	COG0617	tRNA 3'-terminal CCA addition
IOD16_RS23745	COG0517	IMP dehydrogenase activity
IOD16_RS23745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IOD16_RS23760	COG1882	Formate acetyltransferase
IOD16_RS23765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD16_RS23770	COG0659	secondary active sulfate transmembrane transporter activity
IOD16_RS23780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOD16_RS23785	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IOD16_RS23800	COG0517	IMP dehydrogenase activity
IOD16_RS23870	COG2261	transglycosylase associated protein
IOD16_RS23940	COG0427	acetyl-CoA hydrolase
IOD16_RS23960	COG4124	Belongs to the glycosyl hydrolase 26 family
IOD16_RS23970	COG1609	Transcriptional regulator
IOD16_RS23975	COG3509	depolymerase
IOD16_RS23980	COG3345	alpha-galactosidase
IOD16_RS23985	COG0596	Alpha beta hydrolase
IOD16_RS23995	COG2267	carboxylic ester hydrolase activity
IOD16_RS24045	COG2208	phosphoserine phosphatase activity
IOD16_RS24045	COG2770	Histidine kinase
IOD16_RS24075	COG2261	transglycosylase associated protein
IOD16_RS24095	COG0823	Involved in the tonB-independent uptake of proteins
IOD16_RS24095	COG1506	peptidase
IOD16_RS24110	COG0076	glutamate decarboxylase activity
IOD16_RS24165	COG0477	Major facilitator Superfamily
IOD16_RS24190	COG0745	RESPONSE REGULATOR receiver
IOD16_RS24225	COG0384	phenazine biosynthesis protein PhzF
IOD16_RS24240	COG3629	intracellular signal transduction
IOD16_RS24240	COG3903	Transcriptional regulator
IOD16_RS24280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD16_RS24290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD16_RS24305	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IOD16_RS24315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD16_RS24350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOD16_RS24360	COG0300	oxidoreductase activity
IOD16_RS24365	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IOD16_RS24375	COG2124	cytochrome p450
IOD16_RS24425	COG2207	Transcriptional regulator
IOD16_RS24425	COG0662	Cupin 2, conserved barrel domain protein
IOD16_RS24430	COG1733	regulation of RNA biosynthetic process
IOD16_RS24460	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD16_RS24490	COG1175	transmembrane transport
IOD16_RS24495	COG0395	ABC-type sugar transport system, permease component
IOD16_RS24505	COG1609	Transcriptional regulator
IOD16_RS24510	COG0738	Major facilitator superfamily
IOD16_RS24520	COG0577	efflux transmembrane transporter activity
IOD16_RS24520	COG1136	(ABC) transporter
IOD16_RS24525	COG4585	Histidine kinase
IOD16_RS24530	COG2197	response regulator
IOD16_RS24540	COG3903	Transcriptional regulator
IOD16_RS24540	COG3629	intracellular signal transduction
IOD16_RS24545	COG0596	Alpha beta hydrolase
IOD16_RS24600	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD16_RS24650	COG1937	Protein conserved in bacteria
IOD16_RS24660	COG5002	protein histidine kinase activity
IOD16_RS24660	COG5000	phosphorelay sensor kinase activity
IOD16_RS24705	COG2423	ornithine cyclodeaminase activity
IOD16_RS24720	COG3629	intracellular signal transduction
IOD16_RS24720	COG3903	Transcriptional regulator
IOD16_RS24745	COG0248	Ppx GppA phosphatase
IOD16_RS24750	COG0300	oxidoreductase activity
IOD16_RS24790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS24815	COG1012	belongs to the aldehyde dehydrogenase family
IOD16_RS24830	COG2255	four-way junction helicase activity
IOD16_RS24865	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS24910	COG1609	Transcriptional regulator
IOD16_RS24920	COG1309	transcriptional regulator
IOD16_RS24930	COG0739	heme binding
IOD16_RS24935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD16_RS24950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD16_RS24955	COG0596	Alpha beta hydrolase
IOD16_RS24975	COG3757	hydrolase, family 25
IOD16_RS24985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IOD16_RS24995	COG4821	SIS domain
IOD16_RS25005	COG1132	(ABC) transporter
IOD16_RS25020	COG0488	(ABC) transporter
IOD16_RS25095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD16_RS25100	COG4251	negative regulation of phosphorylation
IOD16_RS25100	COG5001	Diguanylate cyclase
IOD16_RS25100	COG2203	Gaf domain
IOD16_RS25100	COG3706	GGDEF domain
IOD16_RS25105	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD16_RS25115	COG2151	metal-sulfur cluster biosynthetic enzyme
IOD16_RS25120	COG0822	iron-sulfur transferase activity
IOD16_RS25130	COG0396	ATPase activity
IOD16_RS25160	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOD16_RS25165	COG0297	glycogen (starch) synthase activity
IOD16_RS25175	COG1131	(ABC) transporter
IOD16_RS25190	COG1510	regulation of RNA biosynthetic process
IOD16_RS25200	COG2018	Roadblock/LC7 domain
IOD16_RS25215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD16_RS25240	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD16_RS25260	COG0109	protoheme IX farnesyltransferase activity
IOD16_RS25270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD16_RS25275	COG0166	Belongs to the GPI family
IOD16_RS25290	COG0363	glucosamine-6-phosphate deaminase activity
IOD16_RS25295	COG4585	Histidine kinase
IOD16_RS25305	COG0596	Alpha beta hydrolase
IOD16_RS25310	COG2815	serine threonine protein kinase
IOD16_RS25310	COG0515	serine threonine protein kinase
IOD16_RS25335	COG0149	triose-phosphate isomerase activity
IOD16_RS25340	COG0126	phosphoglycerate kinase activity
IOD16_RS25350	COG2755	lipolytic protein G-D-S-L family
IOD16_RS25350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IOD16_RS25355	COG1481	regulation of sporulation
IOD16_RS25365	COG1660	Displays ATPase and GTPase activities
IOD16_RS25405	COG2234	aminopeptidase activity
IOD16_RS25415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IOD16_RS25420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD16_RS25420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD16_RS25460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IOD16_RS25465	COG0242	peptide deformylase activity
IOD16_RS25475	COG0405	Gamma-glutamyltransferase
IOD16_RS25480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOD16_RS25485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IOD16_RS25495	COG1758	RNA polymerase activity
IOD16_RS25500	COG0194	GDP metabolic process
IOD16_RS25510	COG0284	orotidine-5'-phosphate decarboxylase activity
IOD16_RS25520	COG0505	Belongs to the CarA family
IOD16_RS25535	COG0540	Belongs to the ATCase OTCase family
IOD16_RS25540	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IOD16_RS25550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IOD16_RS25555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IOD16_RS25575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IOD16_RS25585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD16_RS25590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IOD16_RS25605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD16_RS25610	COG2188	Transcriptional regulator
IOD16_RS25615	COG1263	PTS System
IOD16_RS25620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD16_RS25625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD16_RS25630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOD16_RS25640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IOD16_RS25680	COG2264	protein methyltransferase activity
IOD16_RS25765	COG1122	ATPase activity
IOD16_RS25780	COG0310	cobalt ion transport
IOD16_RS25790	COG3629	intracellular signal transduction
IOD16_RS25805	COG3279	Response regulator of the LytR AlgR family
IOD16_RS25815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD16_RS25820	COG3275	phosphorelay sensor kinase activity
IOD16_RS25835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD16_RS25880	COG1022	Amp-dependent synthetase and ligase
IOD16_RS25905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IOD16_RS25910	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS25930	COG3629	intracellular signal transduction
IOD16_RS25930	COG3903	Transcriptional regulator
IOD16_RS26010	COG0395	ABC-type sugar transport system, permease component
IOD16_RS26030	COG1902	pentaerythritol trinitrate reductase activity
IOD16_RS26040	COG0366	Alpha amylase catalytic
IOD16_RS26045	COG0395	ABC-type sugar transport system, permease component
IOD16_RS26050	COG1175	transmembrane transport
IOD16_RS26090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOD16_RS26105	COG0667	Aldo Keto reductase
IOD16_RS26110	COG1012	belongs to the aldehyde dehydrogenase family
IOD16_RS26110	COG2030	dehydratase
IOD16_RS26125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS26140	COG1794	racemase activity, acting on amino acids and derivatives
IOD16_RS26150	COG3795	YCII-related domain
IOD16_RS26155	COG4941	Belongs to the sigma-70 factor family
IOD16_RS26195	COG0142	geranyltranstransferase activity
IOD16_RS26205	COG0321	lipoyl(octanoyl) transferase activity
IOD16_RS26210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD16_RS26215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD16_RS26220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD16_RS26225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD16_RS26230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD16_RS26390	COG0673	inositol 2-dehydrogenase activity
IOD16_RS26400	COG1609	Transcriptional regulator
IOD16_RS26455	COG2378	regulation of single-species biofilm formation
IOD16_RS26470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IOD16_RS26470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IOD16_RS26490	COG1716	ATPase activity
IOD16_RS26510	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD16_RS26520	COG2172	sigma factor antagonist activity
IOD16_RS26540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD16_RS26545	COG0028	Belongs to the TPP enzyme family
IOD16_RS26565	COG0604	alcohol dehydrogenase
IOD16_RS26590	COG2133	pyrroloquinoline quinone binding
IOD16_RS26605	COG1176	ABC-type spermidine putrescine transport system, permease component I
IOD16_RS26620	COG1595	DNA-templated transcription, initiation
IOD16_RS26640	COG0243	molybdopterin cofactor binding
IOD16_RS26645	COG2197	response regulator
IOD16_RS26660	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IOD16_RS26660	COG1796	DNA polymerase
IOD16_RS26670	COG4585	Histidine kinase
IOD16_RS26675	COG2197	response regulator
IOD16_RS26680	COG2197	response regulator
IOD16_RS26705	COG1022	Amp-dependent synthetase and ligase
IOD16_RS26745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD16_RS26750	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD16_RS26800	COG2018	Roadblock/LC7 domain
IOD16_RS26820	COG1116	anion transmembrane transporter activity
IOD16_RS26820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD16_RS26825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD16_RS26835	COG2319	Wd-40 repeat
IOD16_RS26835	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD16_RS26845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IOD16_RS26850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IOD16_RS26865	COG0640	Transcriptional regulator
IOD16_RS26890	COG0494	nUDIX hydrolase
IOD16_RS26895	COG0504	CTP synthase activity
IOD16_RS26925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOD16_RS26940	COG0647	UMP catabolic process
IOD16_RS26990	COG2094	Belongs to the DNA glycosylase MPG family
IOD16_RS26995	COG0165	Argininosuccinate lyase
IOD16_RS27000	COG0137	argininosuccinate synthase activity
IOD16_RS27005	COG1438	arginine binding
IOD16_RS27015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD16_RS27020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD16_RS27025	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IOD16_RS27030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IOD16_RS27040	COG2124	cytochrome p450
IOD16_RS27060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD16_RS27060	COG0072	phenylalanine-tRNA ligase activity
IOD16_RS27065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IOD16_RS27080	COG0326	Molecular chaperone. Has ATPase activity
IOD16_RS27090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD16_RS27095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IOD16_RS27100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IOD16_RS27105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IOD16_RS27150	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IOD16_RS27155	COG2610	gluconate transmembrane transporter activity
IOD16_RS27180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD16_RS27215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IOD16_RS27255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IOD16_RS27355	COG0328	RNA-DNA hybrid ribonuclease activity
IOD16_RS27370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS27375	COG0640	Transcriptional regulator
IOD16_RS27505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD16_RS27510	COG0823	Involved in the tonB-independent uptake of proteins
IOD16_RS27510	COG4946	Tricorn protease homolog
IOD16_RS27510	COG1506	peptidase
IOD16_RS27520	COG1131	(ABC) transporter
IOD16_RS27535	COG2315	Protein conserved in bacteria
IOD16_RS27565	COG0237	dephospho-CoA kinase activity
IOD16_RS27565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IOD16_RS27575	COG0539	negative regulation of cytoplasmic translation
IOD16_RS27595	COG1511	domain protein
IOD16_RS27600	COG1309	transcriptional regulator
IOD16_RS27615	COG0673	inositol 2-dehydrogenase activity
IOD16_RS27620	COG3226	Transcriptional regulator
IOD16_RS27685	COG0683	leucine binding
IOD16_RS27715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD16_RS27720	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS27740	COG1832	CoA-binding protein
IOD16_RS27750	COG2801	Transposase and inactivated derivatives
IOD16_RS27750	COG3415	Transposase
IOD16_RS27775	COG1357	PFAM Pentapeptide repeats (8 copies)
IOD16_RS27780	COG0514	ATP-dependent DNA helicase (RecQ)
IOD16_RS27790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD16_RS27845	COG2409	Drug exporters of the RND superfamily
IOD16_RS27850	COG1309	transcriptional regulator
IOD16_RS27870	COG0714	Associated with various cellular activities
IOD16_RS27980	COG1937	Protein conserved in bacteria
IOD16_RS28000	COG1595	DNA-templated transcription, initiation
IOD16_RS28005	COG1408	metallophosphoesterase
IOD16_RS28015	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IOD16_RS28040	COG3795	YCII-related domain
IOD16_RS28045	COG4941	Belongs to the sigma-70 factor family
IOD16_RS28050	COG0778	Nitroreductase
IOD16_RS28055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD16_RS28060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IOD16_RS28085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD16_RS28090	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS28100	COG0183	Belongs to the thiolase family
IOD16_RS28105	COG1024	Enoyl-CoA hydratase
IOD16_RS28105	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD16_RS28135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD16_RS28135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD16_RS28150	COG0395	ABC-type sugar transport system, permease component
IOD16_RS28155	COG1175	transmembrane transport
IOD16_RS28170	COG1136	(ABC) transporter
IOD16_RS28170	COG0577	efflux transmembrane transporter activity
IOD16_RS28175	COG1136	(ABC) transporter
IOD16_RS28180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IOD16_RS28180	COG1672	PFAM Archaeal ATPase
IOD16_RS28200	COG3629	intracellular signal transduction
IOD16_RS28200	COG3903	Transcriptional regulator
IOD16_RS28205	COG0586	Pfam SNARE associated Golgi protein
IOD16_RS28225	COG0288	reversible hydration of carbon dioxide
IOD16_RS28235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IOD16_RS28260	COG1280	lysine exporter protein (LysE YggA)
IOD16_RS28265	COG1522	sequence-specific DNA binding
IOD16_RS28270	COG0076	glutamate decarboxylase activity
IOD16_RS28280	COG1946	Acyl-CoA thioesterase
IOD16_RS28315	COG0070	glutamate synthase
IOD16_RS28315	COG0069	glutamate synthase activity
IOD16_RS28315	COG0067	glutamate synthase
IOD16_RS28320	COG1301	dicarboxylic acid transport
IOD16_RS28330	COG0642	Histidine kinase
IOD16_RS28340	COG0745	RESPONSE REGULATOR receiver
IOD16_RS28355	COG0159	tryptophan synthase activity
IOD16_RS28360	COG0133	tryptophan synthase activity
IOD16_RS28365	COG0134	indole-3-glycerol-phosphate synthase activity
IOD16_RS28375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOD16_RS28380	COG1309	transcriptional regulator
IOD16_RS28385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IOD16_RS28395	COG0107	imidazoleglycerol-phosphate synthase activity
IOD16_RS28415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IOD16_RS28420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOD16_RS28430	COG3958	Transketolase
IOD16_RS28435	COG3959	Transketolase, thiamine diphosphate binding domain
IOD16_RS28445	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IOD16_RS28460	COG0131	Imidazoleglycerol-phosphate dehydratase
IOD16_RS28465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD16_RS28470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IOD16_RS28480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD16_RS28505	COG0157	Belongs to the NadC ModD family
IOD16_RS28510	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IOD16_RS28515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IOD16_RS28525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOD16_RS28530	COG0710	3-dehydroquinate dehydratase activity
IOD16_RS28535	COG0475	glutathione-regulated potassium exporter activity
IOD16_RS28540	COG2814	Major facilitator Superfamily
IOD16_RS28545	COG4336	lyase activity
IOD16_RS28560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOD16_RS28565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOD16_RS28570	COG1393	Belongs to the ArsC family
IOD16_RS28580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD16_RS28585	COG2124	cytochrome p450
IOD16_RS28600	COG2814	Major facilitator Superfamily
IOD16_RS28620	COG3263	regulation of cellular component size
IOD16_RS28630	COG3415	Transposase
IOD16_RS28630	COG2801	Transposase and inactivated derivatives
IOD16_RS28660	COG5640	endopeptidase activity
IOD16_RS28665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOD16_RS28685	COG1799	cell septum assembly
IOD16_RS28690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IOD16_RS28705	COG2318	DinB family
IOD16_RS28710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IOD16_RS28715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD16_RS28720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IOD16_RS28745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IOD16_RS28750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD16_RS28765	COG0768	penicillin binding
IOD16_RS28775	COG0275	rRNA processing
IOD16_RS28780	COG2001	Belongs to the MraZ family
IOD16_RS28785	COG0714	Associated with various cellular activities
IOD16_RS28795	COG1305	Transglutaminase-like
IOD16_RS28815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD16_RS28820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD16_RS28850	COG1192	Involved in chromosome partitioning
IOD16_RS28855	COG1280	lysine exporter protein (LysE YggA)
IOD16_RS28860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD16_RS28865	COG0167	dihydroorotate dehydrogenase activity
IOD16_RS28870	COG2233	PERMEase
IOD16_RS28880	COG1842	Phage shock protein A
IOD16_RS28885	COG1396	sequence-specific DNA binding
IOD16_RS28890	COG1058	Belongs to the CinA family
IOD16_RS28890	COG1546	Belongs to the CinA family
IOD16_RS28900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD16_RS28905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IOD16_RS28935	COG1674	ftsk spoiiie
IOD16_RS28950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IOD16_RS28955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD16_RS28965	COG0515	serine threonine protein kinase
IOD16_RS28975	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IOD16_RS28990	COG1309	transcriptional regulator
IOD16_RS29000	COG3214	Protein conserved in bacteria
IOD16_RS29005	COG0697	spore germination
IOD16_RS29010	COG1247	-acetyltransferase
IOD16_RS29035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IOD16_RS29045	COG1185	polyribonucleotide nucleotidyltransferase activity
IOD16_RS29050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IOD16_RS29070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IOD16_RS29085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IOD16_RS29090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IOD16_RS29100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IOD16_RS29115	COG0779	Required for maturation of 30S ribosomal subunits
IOD16_RS29145	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS29150	COG0432	Pfam Uncharacterised protein family UPF0047
IOD16_RS29185	COG0442	prolyl-tRNA aminoacylation
IOD16_RS29195	COG3022	response to hydroperoxide
IOD16_RS29205	COG4977	sequence-specific DNA binding
IOD16_RS29225	COG0513	Belongs to the DEAD box helicase family
IOD16_RS29230	COG0640	Transcriptional regulator
IOD16_RS29240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IOD16_RS29240	COG1648	precorrin-2 dehydrogenase activity
IOD16_RS29290	COG2124	cytochrome p450
IOD16_RS29295	COG0156	8-amino-7-oxononanoate synthase activity
IOD16_RS29310	COG1280	lysine exporter protein (LysE YggA)
IOD16_RS29320	COG0501	Belongs to the peptidase M48B family
IOD16_RS29335	COG0583	DNA-binding transcription factor activity
IOD16_RS29350	COG0110	maltose O-acetyltransferase activity
IOD16_RS29370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOD16_RS29380	COG1881	PFAM PEBP family protein
IOD16_RS29390	COG2807	transmembrane transport
IOD16_RS29395	COG2186	Transcriptional regulator
IOD16_RS29400	COG0583	DNA-binding transcription factor activity
IOD16_RS29405	COG0697	spore germination
IOD16_RS29415	COG1492	cobalamin metabolic process
IOD16_RS29440	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IOD16_RS29445	COG0750	zinc metalloprotease
IOD16_RS29450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IOD16_RS29460	COG2197	response regulator
IOD16_RS29465	COG4585	Histidine kinase
IOD16_RS29475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IOD16_RS29485	COG0667	Aldo Keto reductase
IOD16_RS29500	COG0575	Belongs to the CDS family
IOD16_RS29505	COG0233	cytoplasmic translational termination
IOD16_RS29510	COG0528	UMP kinase activity
IOD16_RS29515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IOD16_RS29520	COG0052	Belongs to the universal ribosomal protein uS2 family
IOD16_RS29530	COG1191	sigma factor activity
IOD16_RS29550	COG0792	nuclease activity
IOD16_RS29560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOD16_RS29565	COG0681	Belongs to the peptidase S26 family
IOD16_RS29570	COG0681	Belongs to the peptidase S26 family
IOD16_RS29575	COG0335	large ribosomal subunit rRNA binding
IOD16_RS29580	COG0336	Belongs to the RNA methyltransferase TrmD family
IOD16_RS29595	COG0228	four-way junction DNA binding
IOD16_RS29600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IOD16_RS29630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IOD16_RS29650	COG4266	Belongs to the allantoicase family
IOD16_RS29655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IOD16_RS29665	COG2351	hydroxyisourate hydrolase activity
IOD16_RS29685	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IOD16_RS29690	COG1414	Transcriptional regulator
IOD16_RS29700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IOD16_RS29755	COG1254	Belongs to the acylphosphatase family
IOD16_RS29760	COG2340	Cysteine-rich secretory protein family
IOD16_RS29780	COG1252	NADH dehydrogenase
IOD16_RS29785	COG3415	Transposase
IOD16_RS29785	COG2801	Transposase and inactivated derivatives
IOD16_RS29800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD16_RS29810	COG0571	ribonuclease III activity
IOD16_RS29815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IOD16_RS29830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IOD16_RS29835	COG0742	ribosomal rna small subunit methyltransferase
IOD16_RS29845	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IOD16_RS29860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOD16_RS29865	COG1461	Dihydroxyacetone kinase
IOD16_RS29870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOD16_RS29875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IOD16_RS29880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD16_RS29905	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD16_RS29910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS29925	COG0626	cystathionine gamma-synthase activity
IOD16_RS29930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IOD16_RS29940	COG1920	GTP binding
IOD16_RS29950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IOD16_RS29965	COG0066	3-isopropylmalate dehydratase activity
IOD16_RS29970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IOD16_RS29995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOD16_RS30005	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD16_RS30015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOD16_RS30030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD16_RS30035	COG0473	3-isopropylmalate dehydrogenase activity
IOD16_RS30055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IOD16_RS30060	COG0440	acetolactate synthase activity
IOD16_RS30080	COG0129	dihydroxy-acid dehydratase activity
IOD16_RS30120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOD16_RS30130	COG0154	amidase activity
IOD16_RS30135	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOD16_RS30170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOD16_RS30185	COG2855	membrane
IOD16_RS30190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD16_RS30195	COG1053	succinate dehydrogenase
IOD16_RS30205	COG0583	DNA-binding transcription factor activity
IOD16_RS30255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD16_RS30265	COG0482	sulfurtransferase activity
IOD16_RS30275	COG2814	Major facilitator Superfamily
IOD16_RS30295	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IOD16_RS30305	COG1307	EDD domain protein, DegV family
IOD16_RS30325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD16_RS30350	COG1733	regulation of RNA biosynthetic process
IOD16_RS30355	COG0110	maltose O-acetyltransferase activity
IOD16_RS30360	COG1957	nucleoside hydrolase
IOD16_RS30370	COG2226	methyltransferase
IOD16_RS30380	COG1119	ATPase activity
IOD16_RS30410	COG0058	SHG alpha-glucan phosphorylase activity
IOD16_RS30415	COG0366	Alpha amylase catalytic
IOD16_RS30420	COG0366	Alpha amylase catalytic
IOD16_RS30430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IOD16_RS30475	COG1846	Transcriptional regulator
IOD16_RS30485	COG2409	Drug exporters of the RND superfamily
IOD16_RS30495	COG1131	(ABC) transporter
IOD16_RS30500	COG3537	Alpha-1,2-mannosidase
IOD16_RS30505	COG3537	Alpha-1,2-mannosidase
IOD16_RS30575	COG0183	Belongs to the thiolase family
IOD16_RS30580	COG0346	lactoylglutathione lyase activity
IOD16_RS30605	COG0596	Alpha beta hydrolase
IOD16_RS30640	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD16_RS30645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD16_RS30655	COG2376	Dihydroxyacetone kinase
IOD16_RS30660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD16_RS30695	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IOD16_RS30715	COG1024	Enoyl-CoA hydratase
IOD16_RS30725	COG4977	sequence-specific DNA binding
IOD16_RS30730	COG1335	isochorismatase
IOD16_RS30735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD16_RS30735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD16_RS30775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IOD16_RS30780	COG1414	Transcriptional regulator
IOD16_RS30785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IOD16_RS30790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IOD16_RS30795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IOD16_RS30800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOD16_RS30805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IOD16_RS30810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOD16_RS30815	COG0356	it plays a direct role in the translocation of protons across the membrane
IOD16_RS30825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD16_RS30845	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD16_RS30860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IOD16_RS30865	COG0254	rRNA binding
IOD16_RS30875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IOD16_RS30880	COG0083	homoserine kinase activity
IOD16_RS30885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOD16_RS30890	COG0460	homoserine dehydrogenase
IOD16_RS30895	COG0019	diaminopimelate decarboxylase activity
IOD16_RS30900	COG0018	arginyl-trna synthetase
IOD16_RS30920	COG1940	carbohydrate kinase activity
IOD16_RS30920	COG1846	Transcriptional regulator
IOD16_RS30925	COG3537	Alpha-1,2-mannosidase
IOD16_RS31205	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD16_RS31225	COG2267	carboxylic ester hydrolase activity
IOD16_RS31230	COG0640	Transcriptional regulator
IOD16_RS31240	COG1024	Enoyl-CoA hydratase
IOD16_RS31245	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS31310	COG0697	spore germination
IOD16_RS31315	COG2910	NAD(P)H-binding
IOD16_RS31320	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS31330	COG1522	sequence-specific DNA binding
IOD16_RS31340	COG0590	tRNA wobble adenosine to inosine editing
IOD16_RS31365	COG1482	cell wall glycoprotein biosynthetic process
IOD16_RS31375	COG0667	Aldo Keto reductase
IOD16_RS31425	COG4608	Belongs to the ABC transporter superfamily
IOD16_RS31430	COG0444	Belongs to the ABC transporter superfamily
IOD16_RS31435	COG0601	transmembrane transport
IOD16_RS31465	COG2259	Doxx family
IOD16_RS31470	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS31475	COG3795	YCII-related domain
IOD16_RS31480	COG4941	Belongs to the sigma-70 factor family
IOD16_RS31545	COG0640	Transcriptional regulator
IOD16_RS31555	COG1940	carbohydrate kinase activity
IOD16_RS31560	COG0673	inositol 2-dehydrogenase activity
IOD16_RS31565	COG4702	Belongs to the UPF0303 family
IOD16_RS31620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD16_RS31635	COG2205	protein histidine kinase activity
IOD16_RS31690	COG3903	Transcriptional regulator
IOD16_RS31690	COG3629	intracellular signal transduction
IOD16_RS31715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD16_RS31720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD16_RS31730	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS31735	COG1024	Enoyl-CoA hydratase
IOD16_RS31740	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS31750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD16_RS31780	COG2197	response regulator
IOD16_RS31795	COG3469	chitinase activity
IOD16_RS31800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD16_RS31810	COG0673	inositol 2-dehydrogenase activity
IOD16_RS31820	COG0477	Major facilitator Superfamily
IOD16_RS31830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOD16_RS31845	COG0386	Belongs to the glutathione peroxidase family
IOD16_RS31850	COG1760	l-serine dehydratase
IOD16_RS31855	COG0509	glycine decarboxylation via glycine cleavage system
IOD16_RS31885	COG1132	(ABC) transporter
IOD16_RS31910	COG0567	Dehydrogenase, E1 component
IOD16_RS31910	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD16_RS31920	COG0667	Aldo Keto reductase
IOD16_RS31935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD16_RS31940	COG1228	amidohydrolase
IOD16_RS31955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IOD16_RS31960	COG2986	histidine ammonia-lyase
IOD16_RS31965	COG4555	ABC transporter
IOD16_RS32005	COG1174	glycine betaine transport
IOD16_RS32010	COG0517	IMP dehydrogenase activity
IOD16_RS32010	COG1125	glycine betaine transport
IOD16_RS32035	COG5001	Diguanylate cyclase
IOD16_RS32035	COG3300	MHYT domain
IOD16_RS32045	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IOD16_RS32060	COG0406	alpha-ribazole phosphatase activity
IOD16_RS32065	COG0456	acetyltransferase
IOD16_RS32075	COG1846	Transcriptional regulator
IOD16_RS32095	COG1597	lipid kinase activity
IOD16_RS32110	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IOD16_RS32115	COG5662	AntiSigma factor
IOD16_RS32120	COG1595	DNA-templated transcription, initiation
IOD16_RS32125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD16_RS32135	COG2135	peptidase activity
IOD16_RS32140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOD16_RS32150	COG3693	PFAM glycoside hydrolase, family 10
IOD16_RS32175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD16_RS32180	COG1011	Hydrolase
IOD16_RS32190	COG0653	protein targeting
IOD16_RS32195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD16_RS32205	COG5401	PFAM Sporulation and spore germination
IOD16_RS32210	COG5002	protein histidine kinase activity
IOD16_RS32215	COG0745	RESPONSE REGULATOR receiver
IOD16_RS32230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IOD16_RS32245	COG0531	amino acid
IOD16_RS32265	COG1482	cell wall glycoprotein biosynthetic process
IOD16_RS32275	COG2835	tetraacyldisaccharide 4'-kinase activity
IOD16_RS32305	COG1994	Peptidase M50
IOD16_RS32310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IOD16_RS32315	COG0778	Nitroreductase
IOD16_RS32315	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IOD16_RS32330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IOD16_RS32355	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS32405	COG1316	TRANSCRIPTIONal
IOD16_RS32410	COG1316	TRANSCRIPTIONal
IOD16_RS32480	COG1131	(ABC) transporter
IOD16_RS32485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS32520	COG0483	inositol monophosphate 1-phosphatase activity
IOD16_RS32525	COG0745	RESPONSE REGULATOR receiver
IOD16_RS32530	COG2205	protein histidine kinase activity
IOD16_RS32580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD16_RS32600	COG1301	dicarboxylic acid transport
IOD16_RS32610	COG4770	biotin carboxylase activity
IOD16_RS32670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD16_RS32675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD16_RS32680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD16_RS32705	COG1473	amidohydrolase
IOD16_RS32705	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD16_RS32710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD16_RS32745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD16_RS32765	COG0667	Aldo Keto reductase
IOD16_RS32780	COG3654	unkown
IOD16_RS32800	COG0702	epimerase
IOD16_RS32825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IOD16_RS32830	COG1012	belongs to the aldehyde dehydrogenase family
IOD16_RS32850	COG1131	(ABC) transporter
IOD16_RS32860	COG1595	DNA-templated transcription, initiation
IOD16_RS32895	COG0791	NLP P60 protein
IOD16_RS32895	COG3883	PFAM NLP P60 protein
IOD16_RS32915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD16_RS32935	COG1079	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS32940	COG4603	Belongs to the binding-protein-dependent transport system permease family
IOD16_RS32945	COG3845	ABC transporter
IOD16_RS32950	COG1744	ABC transporter substrate-binding protein PnrA-like
IOD16_RS32975	COG2009	succinate dehydrogenase
IOD16_RS32985	COG1053	succinate dehydrogenase
IOD16_RS32990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD16_RS32995	COG1686	Belongs to the peptidase S11 family
IOD16_RS33010	COG1295	ribonuclease BN
IOD16_RS33015	COG0180	Tryptophanyl-tRNA synthetase
IOD16_RS33025	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IOD16_RS33080	COG0484	heat shock protein binding
IOD16_RS33105	COG2814	Major facilitator Superfamily
IOD16_RS33110	COG0640	Transcriptional regulator
IOD16_RS33130	COG1131	(ABC) transporter
IOD16_RS33160	COG0039	L-malate dehydrogenase activity
IOD16_RS33210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IOD16_RS33240	COG0587	DNA-directed DNA polymerase activity
IOD16_RS33290	COG0045	succinate-CoA ligase (ADP-forming) activity
IOD16_RS33305	COG0739	heme binding
IOD16_RS33345	COG0515	serine threonine protein kinase
IOD16_RS33350	COG2815	serine threonine protein kinase
IOD16_RS33350	COG0515	serine threonine protein kinase
IOD16_RS33355	COG0583	DNA-binding transcription factor activity
IOD16_RS33370	COG2815	serine threonine protein kinase
IOD16_RS33370	COG0515	serine threonine protein kinase
IOD16_RS33395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD16_RS33395	COG0519	Catalyzes the synthesis of GMP from XMP
IOD16_RS33405	COG1012	belongs to the aldehyde dehydrogenase family
IOD16_RS33420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IOD16_RS33420	COG2124	cytochrome p450
IOD16_RS33440	COG0516	GMP reductase activity
IOD16_RS33490	COG0459	protein refolding
IOD16_RS33495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IOD16_RS33515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IOD16_RS33520	COG0456	acetyltransferase
IOD16_RS33540	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS33545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IOD16_RS33545	COG0825	malonyl-CoA metabolic process
IOD16_RS33550	COG0802	atpase or kinase
IOD16_RS33560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOD16_RS33570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD16_RS33600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD16_RS33605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IOD16_RS33610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IOD16_RS33630	COG0443	Heat shock 70 kDa protein
IOD16_RS33635	COG3629	intracellular signal transduction
IOD16_RS33635	COG3903	Transcriptional regulator
IOD16_RS33645	COG3903	Transcriptional regulator
IOD16_RS33645	COG3629	intracellular signal transduction
IOD16_RS33650	COG1674	ftsk spoiiie
IOD16_RS33660	COG1404	Belongs to the peptidase S8 family
IOD16_RS33705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD16_RS33715	COG0101	tRNA pseudouridine synthase activity
IOD16_RS33720	COG0203	ribosomal protein L17
IOD16_RS33725	COG0202	RNA polymerase activity
IOD16_RS33730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IOD16_RS33735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IOD16_RS33740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IOD16_RS33745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOD16_RS33750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IOD16_RS33770	COG0563	adenylate kinase activity
IOD16_RS33790	COG1841	ribosomal large subunit assembly
IOD16_RS33795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IOD16_RS33800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IOD16_RS33810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IOD16_RS33815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IOD16_RS33820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IOD16_RS33825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IOD16_RS33830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IOD16_RS33835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IOD16_RS33850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IOD16_RS33855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IOD16_RS33860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IOD16_RS33865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IOD16_RS33870	COG0089	rRNA binding
IOD16_RS33875	COG0088	Forms part of the polypeptide exit tunnel
IOD16_RS33880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IOD16_RS33885	COG0051	transcription antitermination factor activity, RNA binding
IOD16_RS33890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD16_RS33895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD16_RS33900	COG0049	tRNA binding
IOD16_RS33905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IOD16_RS33935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IOD16_RS33940	COG0085	RNA polymerase activity
IOD16_RS33990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOD16_RS34020	COG0081	regulation of translation
IOD16_RS34025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IOD16_RS34035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD16_RS34045	COG0436	Aminotransferase
IOD16_RS34065	COG2030	dehydratase
IOD16_RS34070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOD16_RS34090	COG0384	phenazine biosynthesis protein PhzF
IOD16_RS34130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD16_RS34190	COG1666	GTP binding
IOD16_RS34205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD16_RS34210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD16_RS34215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD16_RS34245	COG1834	amidinotransferase
IOD16_RS34250	COG1522	sequence-specific DNA binding
IOD16_RS34260	COG0674	pyruvate-flavodoxin oxidoreductase activity
IOD16_RS34260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IOD16_RS34265	COG1013	pyruvate-flavodoxin oxidoreductase activity
IOD16_RS34280	COG0142	geranyltranstransferase activity
IOD16_RS34285	COG1007	ATP synthesis coupled electron transport
IOD16_RS34300	COG0713	ATP synthesis coupled electron transport
IOD16_RS34310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD16_RS34315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IOD16_RS34320	COG1034	ATP synthesis coupled electron transport
IOD16_RS34325	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IOD16_RS34335	COG0649	NAD binding
IOD16_RS34340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD16_RS34345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD16_RS34355	COG0644	oxidoreductase
IOD16_RS34360	COG2226	methyltransferase
IOD16_RS34365	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS34370	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS34385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD16_RS34390	COG2151	metal-sulfur cluster biosynthetic enzyme
IOD16_RS34395	COG3396	Phenylacetate-CoA oxygenase
IOD16_RS34400	COG3460	Phenylacetate-CoA oxygenase
IOD16_RS34405	COG3396	Phenylacetate-CoA oxygenase
IOD16_RS34415	COG1169	isochorismate synthase
IOD16_RS34435	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IOD16_RS34490	COG1522	sequence-specific DNA binding
IOD16_RS34510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD16_RS34515	COG1333	cytochrome c biogenesis protein
IOD16_RS34535	COG0406	alpha-ribazole phosphatase activity
IOD16_RS34540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IOD16_RS34585	COG0113	porphobilinogen synthase activity
IOD16_RS34590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IOD16_RS34590	COG1587	Uroporphyrinogen-III synthase
IOD16_RS34595	COG0181	hydroxymethylbilane synthase activity
IOD16_RS34600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IOD16_RS34605	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IOD16_RS34620	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS34660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IOD16_RS34670	COG0506	proline dehydrogenase activity
IOD16_RS34695	COG5002	protein histidine kinase activity
IOD16_RS34700	COG0667	Aldo Keto reductase
IOD16_RS34710	COG0588	phosphoglycerate mutase activity
IOD16_RS34720	COG0318	PFAM AMP-dependent synthetase and ligase
IOD16_RS34735	COG0438	transferase activity, transferring glycosyl groups
IOD16_RS34770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IOD16_RS34800	COG0154	amidase activity
IOD16_RS34825	COG0693	protein deglycase activity
IOD16_RS34850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IOD16_RS34870	COG2733	membrane
IOD16_RS34885	COG1136	(ABC) transporter
IOD16_RS34920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS34925	COG2364	Membrane
IOD16_RS34980	COG1278	Cold shock
IOD16_RS34985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD16_RS35000	COG2255	four-way junction helicase activity
IOD16_RS35030	COG0708	Exodeoxyribonuclease III
IOD16_RS35070	COG1316	TRANSCRIPTIONal
IOD16_RS35100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IOD16_RS35120	COG0456	acetyltransferase
IOD16_RS35125	COG0745	RESPONSE REGULATOR receiver
IOD16_RS35160	COG4044	May play a role in the intracellular transport of hydrophobic ligands
IOD16_RS35165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IOD16_RS35170	COG1984	allophanate hydrolase subunit 2
IOD16_RS35185	COG0735	belongs to the Fur family
IOD16_RS35195	COG3246	L-lysine catabolic process to acetate
IOD16_RS35205	COG2271	Major facilitator Superfamily
IOD16_RS35220	COG1902	pentaerythritol trinitrate reductase activity
IOD16_RS35240	COG3903	Transcriptional regulator
IOD16_RS35240	COG3629	intracellular signal transduction
IOD16_RS35245	COG3962	Belongs to the TPP enzyme family
IOD16_RS35250	COG3718	enzyme involved in inositol metabolism
IOD16_RS35265	COG1129	ABC transporter
IOD16_RS35280	COG1082	Xylose isomerase domain protein TIM barrel
IOD16_RS35295	COG2076	Multidrug Resistance protein
IOD16_RS35300	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS35320	COG2226	methyltransferase
IOD16_RS35335	COG1595	DNA-templated transcription, initiation
IOD16_RS35340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IOD16_RS35405	COG3387	PFAM Glycoside hydrolase 15-related
IOD16_RS35410	COG1063	alcohol dehydrogenase
IOD16_RS35435	COG0583	DNA-binding transcription factor activity
IOD16_RS35440	COG0667	Aldo Keto reductase
IOD16_RS35455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD16_RS35460	COG0047	phosphoribosylformylglycinamidine synthase activity
IOD16_RS35465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD16_RS35490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IOD16_RS35500	COG0765	amino acid transport
IOD16_RS35515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD16_RS35525	COG1595	DNA-templated transcription, initiation
IOD16_RS35545	COG1595	DNA-templated transcription, initiation
IOD16_RS35555	COG1011	Hydrolase
IOD16_RS35560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD16_RS35570	COG0436	Aminotransferase
IOD16_RS35625	COG0584	glycerophosphoryl diester phosphodiesterase
IOD16_RS35640	COG1116	anion transmembrane transporter activity
IOD16_RS35645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD16_RS35650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOD16_RS35670	COG4129	membrane
IOD16_RS35685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD16_RS35705	COG0667	Aldo Keto reductase
IOD16_RS35725	COG1940	carbohydrate kinase activity
IOD16_RS35745	COG0277	FAD linked oxidase domain protein
IOD16_RS35750	COG0586	Pfam SNARE associated Golgi protein
IOD16_RS35755	COG1072	(Pantothenic acid kinase))
IOD16_RS35760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD16_RS35820	COG4221	oxidoreductase activity
IOD16_RS35830	COG0542	response to heat
IOD16_RS35840	COG2871	sodium ion transport
IOD16_RS35850	COG0789	Transcriptional regulator
IOD16_RS35855	COG0484	heat shock protein binding
IOD16_RS35860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IOD16_RS35865	COG0443	Heat shock 70 kDa protein
IOD16_RS35890	COG0247	lactate metabolic process
IOD16_RS35890	COG2181	nitrate reductase activity
IOD16_RS35895	COG1950	PFAM Membrane protein of
IOD16_RS35910	COG0717	Belongs to the dCTP deaminase family
IOD16_RS35940	COG1846	Transcriptional regulator
IOD16_RS35965	COG2197	response regulator
IOD16_RS35970	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS35985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IOD16_RS36015	COG0183	Belongs to the thiolase family
IOD16_RS36020	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS36030	COG1846	Transcriptional regulator
IOD16_RS36040	COG1309	transcriptional regulator
IOD16_RS36050	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS36055	COG4974	Belongs to the 'phage' integrase family
IOD16_RS36115	COG0789	Transcriptional regulator
IOD16_RS36120	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD16_RS36125	COG0022	dehydrogenase e1 component
IOD16_RS36150	COG0765	amino acid transport
IOD16_RS36225	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IOD16_RS36260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IOD16_RS36275	COG4585	Histidine kinase
IOD16_RS36280	COG2197	response regulator
IOD16_RS36295	COG3830	Belongs to the UPF0237 family
IOD16_RS36295	COG0560	Phosphoserine phosphatase
IOD16_RS36300	COG1131	(ABC) transporter
IOD16_RS36315	COG1404	Belongs to the peptidase S8 family
IOD16_RS36325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOD16_RS36330	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
IOD16_RS36345	COG0402	S-adenosylhomocysteine deaminase activity
IOD16_RS36350	COG4221	oxidoreductase activity
IOD16_RS36365	COG2814	Major facilitator Superfamily
IOD16_RS36370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD16_RS36375	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS36380	COG1260	myo-inositol-1-phosphate synthase
IOD16_RS36395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD16_RS36425	COG0360	Binds together with S18 to 16S ribosomal RNA
IOD16_RS36430	COG0629	single-stranded DNA binding
IOD16_RS36435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IOD16_RS36440	COG0359	binds to the 23S rRNA
IOD16_RS36515	COG2197	response regulator
IOD16_RS36525	COG0702	epimerase
IOD16_RS36530	COG1063	alcohol dehydrogenase
IOD16_RS36535	COG0156	8-amino-7-oxononanoate synthase activity
IOD16_RS36545	COG0583	DNA-binding transcription factor activity
IOD16_RS36565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD16_RS36570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD16_RS36600	COG0495	leucyl-tRNA aminoacylation
IOD16_RS36610	COG1678	Uncharacterized ACR, COG1678
IOD16_RS36620	COG2197	response regulator
IOD16_RS36625	COG0617	tRNA 3'-terminal CCA addition
IOD16_RS36650	COG1595	DNA-templated transcription, initiation
IOD16_RS36665	COG3118	belongs to the thioredoxin family
IOD16_RS36665	COG0492	ferredoxin-NADP+ reductase activity
IOD16_RS36670	COG3409	Peptidoglycan-binding domain 1 protein
IOD16_RS36670	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD16_RS36695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD16_RS36700	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD16_RS36710	COG1192	Involved in chromosome partitioning
IOD16_RS36715	COG0357	Ribosomal RNA small subunit methyltransferase G
IOD16_RS36720	COG0494	nUDIX hydrolase
IOD16_RS36725	COG4106	trans-aconitate 2-methyltransferase activity
IOD16_RS36735	COG0706	membrane insertase activity
IOD16_RS36740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOD16_RS36745	COG0594	ribonuclease P activity
IOD16_RS36750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IOD16_RS36755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IOD16_RS36760	COG0592	DNA-directed DNA polymerase activity
IOD16_RS36765	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IOD16_RS36770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IOD16_RS36775	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IOD16_RS36805	COG2259	Doxx family
IOD16_RS36825	COG0705	Rhomboid family
IOD16_RS36825	COG0457	Tetratricopeptide repeat
IOD16_RS36865	COG0515	serine threonine protein kinase
IOD16_RS36870	COG0768	penicillin binding
IOD16_RS36885	COG1716	ATPase activity
IOD16_RS36890	COG1716	ATPase activity
IOD16_RS36930	COG1309	transcriptional regulator
IOD16_RS36940	COG2211	Major facilitator Superfamily
IOD16_RS36945	COG0300	oxidoreductase activity
IOD16_RS36985	COG1276	copper resistance
IOD16_RS36985	COG2372	response to copper ion
IOD16_RS37000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD16_RS37020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IOD16_RS37040	COG4585	Histidine kinase
IOD16_RS37045	COG2197	response regulator
IOD16_RS37095	COG1132	(ABC) transporter
IOD16_RS37135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD16_RS37145	COG3275	phosphorelay sensor kinase activity
IOD16_RS37160	COG3279	Response regulator of the LytR AlgR family
IOD16_RS37170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD16_RS37180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD16_RS37185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD16_RS37210	COG0584	glycerophosphoryl diester phosphodiesterase
IOD16_RS37225	COG0653	protein targeting
IOD16_RS37235	COG1191	sigma factor activity
IOD16_RS37255	COG1528	Iron-storage protein
IOD16_RS37270	COG0459	protein refolding
IOD16_RS37300	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IOD16_RS37310	COG0714	Associated with various cellular activities
IOD16_RS37355	COG1271	oxidase subunit
IOD16_RS37360	COG1294	oxidase, subunit
IOD16_RS37365	COG4988	ABC transporter
IOD16_RS37380	COG0454	-acetyltransferase
IOD16_RS37385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IOD16_RS37415	COG0754	glutathionylspermidine amidase activity
IOD16_RS37420	COG3766	membrane
IOD16_RS37430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IOD16_RS37435	COG0579	oxidoreductase
IOD16_RS37445	COG0561	phosphatase activity
IOD16_RS37450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD16_RS37460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOD16_RS37470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOD16_RS37475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOD16_RS37485	COG0463	Glycosyl transferase, family 2
IOD16_RS37515	COG1216	Glycosyl transferase, family 2
IOD16_RS37530	COG1216	Glycosyl transferase, family 2
IOD16_RS37575	COG2234	aminopeptidase activity
IOD16_RS37605	COG4085	toxin activity
IOD16_RS37605	COG1525	nuclease
IOD16_RS37605	COG0737	Belongs to the 5'-nucleotidase family
IOD16_RS37640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD16_RS37665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD16_RS37690	COG0667	Aldo Keto reductase
IOD16_RS37695	COG2207	Transcriptional regulator
IOD16_RS37710	COG0604	alcohol dehydrogenase
IOD16_RS37720	COG1686	Belongs to the peptidase S11 family
IOD16_RS37725	COG1234	tRNA 3'-trailer cleavage
IOD16_RS37795	COG0183	Belongs to the thiolase family
IOD16_RS37810	COG0287	Prephenate dehydrogenase
IOD16_RS37815	COG1473	amidohydrolase
IOD16_RS37865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IOD16_RS37925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IOD16_RS37930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOD16_RS37935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IOD16_RS37940	COG3629	intracellular signal transduction
IOD16_RS37940	COG3903	Transcriptional regulator
IOD16_RS37945	COG0747	negative chemotaxis
IOD16_RS37950	COG0601	transmembrane transport
IOD16_RS37955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD16_RS37960	COG0444	Belongs to the ABC transporter superfamily
IOD16_RS37965	COG4608	Belongs to the ABC transporter superfamily
IOD16_RS37970	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS38000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOD16_RS38025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD16_RS38030	COG1070	Carbohydrate kinase
IOD16_RS38040	COG0500	methyltransferase
IOD16_RS38060	COG0657	acetylesterase activity
IOD16_RS38070	COG1764	response to oxidative stress
IOD16_RS38105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD16_RS38130	COG1408	metallophosphoesterase
IOD16_RS38140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD16_RS38150	COG3415	Transposase
IOD16_RS38150	COG2801	Transposase and inactivated derivatives
IOD16_RS38205	COG0673	inositol 2-dehydrogenase activity
IOD16_RS38220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD16_RS38230	COG1733	regulation of RNA biosynthetic process
IOD16_RS38260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD16_RS38265	COG0494	nUDIX hydrolase
IOD16_RS38275	COG3415	Transposase
IOD16_RS38275	COG2801	Transposase and inactivated derivatives
IOD16_RS38280	COG0596	Alpha beta hydrolase
IOD16_RS38290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOD16_RS38295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD16_RS38310	COG3844	kynureninase activity
IOD16_RS38320	COG1522	sequence-specific DNA binding
IOD16_RS38325	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IOD16_RS38330	COG1737	Transcriptional regulator
IOD16_RS38335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD16_RS38340	COG3876	Protein conserved in bacteria
IOD16_RS38345	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS38395	COG1111	helicase
IOD16_RS38395	COG1205	dead DEAH box helicase
IOD16_RS38400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IOD16_RS38420	COG1754	DNA topoisomerase type I activity
IOD16_RS38420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOD16_RS38430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IOD16_RS38435	COG0470	DNA polymerase III
IOD16_RS38485	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IOD16_RS38490	COG2027	D-alanyl-D-alanine carboxypeptidase
IOD16_RS38500	COG0037	tRNA processing
IOD16_RS38515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD16_RS38525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOD16_RS38530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD16_RS38555	COG0649	NAD binding
IOD16_RS38590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IOD16_RS38595	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IOD16_RS38600	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IOD16_RS38610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IOD16_RS38620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD16_RS38625	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD16_RS38630	COG1120	ATPase activity
IOD16_RS38645	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IOD16_RS38685	COG1194	a g-specific adenine glycosylase
IOD16_RS38700	COG1609	Transcriptional regulator
IOD16_RS38710	COG1653	transport
IOD16_RS38715	COG1175	transmembrane transport
IOD16_RS38720	COG0395	ABC-type sugar transport system, permease component
IOD16_RS38735	COG3842	ATPase activity
IOD16_RS38745	COG3842	ATPase activity
IOD16_RS38770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD16_RS38775	COG0215	cysteine-tRNA ligase activity
IOD16_RS38790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IOD16_RS38795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IOD16_RS38800	COG1329	Transcriptional regulator
IOD16_RS38810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IOD16_RS38840	COG0667	Aldo Keto reductase
IOD16_RS38845	COG2205	protein histidine kinase activity
IOD16_RS38850	COG0745	RESPONSE REGULATOR receiver
IOD16_RS38875	COG1486	melibiose metabolic process
IOD16_RS38880	COG0395	ABC-type sugar transport system, permease component
IOD16_RS38885	COG1175	transmembrane transport
IOD16_RS38895	COG1940	carbohydrate kinase activity
IOD16_RS38905	COG2971	BadF BadG BcrA BcrD
IOD16_RS38910	COG1404	Belongs to the peptidase S8 family
IOD16_RS38915	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD16_RS38920	COG4948	Mandelate Racemase Muconate Lactonizing
IOD16_RS38925	COG1028	Short-chain dehydrogenase reductase Sdr
IOD16_RS38930	COG2186	Transcriptional regulator
IOD16_RS38935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IOD16_RS38940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD16_RS38945	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD16_RS38950	COG0395	ABC-type sugar transport system, permease component
IOD16_RS38955	COG1175	transmembrane transport
IOD16_RS38960	COG2182	Extracellular solute-binding protein
IOD16_RS38965	COG2188	Transcriptional regulator
IOD16_RS38980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD16_RS38990	COG3384	dioxygenase
IOD16_RS38995	COG0352	thiamine-phosphate diphosphorylase activity
IOD16_RS39000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD16_RS39000	COG2022	thiamine diphosphate biosynthetic process
IOD16_RS39010	COG2022	thiamine diphosphate biosynthetic process
IOD16_RS39035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IOD16_RS39045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD16_RS39060	COG0242	peptide deformylase activity
IOD16_RS39070	COG0688	phosphatidylethanolamine metabolic process
IOD16_RS39085	COG1278	Cold shock
IOD16_RS39095	COG0459	protein refolding
IOD16_RS39125	COG2182	Extracellular solute-binding protein
IOD16_RS39130	COG1175	transmembrane transport
IOD16_RS39135	COG0395	ABC-type sugar transport system, permease component
IOD16_RS39140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IOD16_RS39220	COG4948	Mandelate Racemase Muconate Lactonizing
IOD16_RS39270	COG2018	Roadblock/LC7 domain
IOD16_RS39315	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD16_RS39315	COG0315	cyclic pyranopterin monophosphate synthase activity
IOD16_RS39340	COG1846	Transcriptional regulator
IOD16_RS39365	COG3304	Inner membrane component domain
IOD16_RS39380	COG0546	phosphoglycolate phosphatase activity
IOD16_RS39390	COG1278	Cold shock
IOD16_RS39400	COG2814	Major facilitator Superfamily
IOD16_RS39405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD16_RS39430	COG2252	PERMEase
IOD16_RS39440	COG2814	Major facilitator Superfamily
IOD16_RS39450	COG0488	(ABC) transporter
IOD16_RS39470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD16_RS39480	COG1132	(ABC) transporter
IOD16_RS39485	COG1132	(ABC) transporter
IOD16_RS39510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IOD16_RS39530	COG0831	urea catabolic process
IOD16_RS39535	COG0832	Belongs to the urease beta subunit family
IOD16_RS39540	COG0804	urea catabolic process
IOD16_RS39550	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD16_RS39560	COG0829	nickel cation binding
IOD16_RS39565	COG0259	pyridoxamine-phosphate oxidase activity
IOD16_RS39575	COG3263	regulation of cellular component size
IOD16_RS39605	COG0531	amino acid
IOD16_RS39625	COG1309	transcriptional regulator
IOD16_RS39630	COG2017	converts alpha-aldose to the beta-anomer
IOD16_RS39635	COG1228	amidohydrolase
IOD16_RS39640	COG1960	acyl-CoA dehydrogenase activity
IOD16_RS39670	COG0415	Belongs to the DNA photolyase family
IOD16_RS39675	COG1668	transmembrane transport
IOD16_RS39680	COG4152	abc transporter atp-binding protein
IOD16_RS39715	COG0277	FAD linked oxidase domain protein
IOD16_RS39730	COG2130	NADP-dependent
IOD16_RS39740	COG0456	acetyltransferase
IOD16_RS39750	COG1674	ftsk spoiiie
IOD16_RS39795	COG1733	regulation of RNA biosynthetic process
IOD16_RS39800	COG0702	epimerase
IOD16_RS39815	COG0384	phenazine biosynthesis protein PhzF
IOD16_RS39820	COG0583	DNA-binding transcription factor activity