locus-tag	class	description
SRM_RS00285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SRM_RS00285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SRM_RS00430	COG0445	tRNA wobble uridine modification
SRM_RS00735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SRM_RS00760	COG1028	Short-chain dehydrogenase reductase Sdr
SRM_RS00765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SRM_RS00785	COG1862	Preprotein translocase
SRM_RS00790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SRM_RS00790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SRM_RS00800	COG2333	competence protein COMEC
SRM_RS00800	COG0658	competence protein
SRM_RS00805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SRM_RS00810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SRM_RS00815	COG0012	GTP binding
SRM_RS00830	COG1809	phosphosulfolactate synthase activity
SRM_RS00835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SRM_RS00840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SRM_RS00865	COG1573	uracil-dna glycosylase
SRM_RS00880	COG0194	GDP metabolic process
SRM_RS00885	COG1561	YicC-like family, N-terminal region
SRM_RS00895	COG0233	cytoplasmic translational termination
SRM_RS00900	COG0528	UMP kinase activity
SRM_RS00905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SRM_RS00910	COG0052	Belongs to the universal ribosomal protein uS2 family
SRM_RS00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SRM_RS00920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SRM_RS00930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SRM_RS00935	COG0416	fatty acid biosynthetic process
SRM_RS00940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SRM_RS00945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SRM_RS01005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SRM_RS01010	COG0594	ribonuclease P activity
SRM_RS01015	COG0706	membrane insertase activity
SRM_RS01020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SRM_RS01045	COG0445	tRNA wobble uridine modification
SRM_RS01050	COG0357	Ribosomal RNA small subunit methyltransferase G
SRM_RS01060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SRM_RS01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SRM_RS01095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SRM_RS01140	COG2205	protein histidine kinase activity
SRM_RS01140	COG0745	RESPONSE REGULATOR receiver
SRM_RS01140	COG3292	Two component regulator propeller
SRM_RS01150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SRM_RS01155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SRM_RS01160	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SRM_RS01165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SRM_RS01180	COG1309	transcriptional regulator
SRM_RS01190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRM_RS01205	COG2205	protein histidine kinase activity
SRM_RS01205	COG2198	Histidine kinase
SRM_RS01205	COG0784	Response regulator, receiver
SRM_RS01215	COG4191	Histidine kinase
SRM_RS01245	COG2205	protein histidine kinase activity
SRM_RS01270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SRM_RS01280	COG0501	Belongs to the peptidase M48B family
SRM_RS01285	COG1999	signal sequence binding
SRM_RS01300	COG0745	RESPONSE REGULATOR receiver
SRM_RS01300	COG2205	protein histidine kinase activity
SRM_RS01300	COG3292	Two component regulator propeller
SRM_RS01300	COG3292	Two component regulator propeller
SRM_RS01300	COG0745	RESPONSE REGULATOR receiver
SRM_RS01300	COG2205	protein histidine kinase activity
SRM_RS01305	COG2207	Transcriptional regulator
SRM_RS01305	COG1917	Cupin 2, conserved barrel domain protein
SRM_RS01310	COG0791	NLP P60 protein
SRM_RS01340	COG0366	Alpha amylase catalytic
SRM_RS01340	COG3103	Sh3 type 3 domain protein
SRM_RS01360	COG2340	Cysteine-rich secretory protein family
SRM_RS01365	COG0640	Transcriptional regulator
SRM_RS01385	COG1960	acyl-CoA dehydrogenase activity
SRM_RS01455	COG0642	Histidine kinase
SRM_RS01470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SRM_RS01480	COG2807	transmembrane transport
SRM_RS01495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SRM_RS01525	COG0589	response to stress
SRM_RS01530	COG0642	Histidine kinase
SRM_RS01535	COG2205	protein histidine kinase activity
SRM_RS01535	COG2198	Histidine kinase
SRM_RS01535	COG0784	Response regulator, receiver
SRM_RS01555	COG1131	(ABC) transporter
SRM_RS01605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SRM_RS01620	COG5278	phosphoserine phosphatase activity
SRM_RS01620	COG0840	transmembrane signaling receptor activity
SRM_RS01665	COG1629	transport
SRM_RS01665	COG4206	TonB-dependent receptor
SRM_RS01675	COG0784	Response regulator, receiver
SRM_RS01675	COG2205	protein histidine kinase activity
SRM_RS01675	COG5002	protein histidine kinase activity
SRM_RS01685	COG1131	(ABC) transporter
SRM_RS01715	COG0367	asparagine synthase
SRM_RS01865	COG1132	(ABC) transporter
SRM_RS01885	COG0438	transferase activity, transferring glycosyl groups
SRM_RS01890	COG1216	Glycosyl transferase, family 2
SRM_RS01935	COG0438	transferase activity, transferring glycosyl groups
SRM_RS01985	COG0367	asparagine synthase
SRM_RS01985	COG0367	asparagine synthase
SRM_RS02065	COG0459	protein refolding
SRM_RS02070	COG1785	Belongs to the alkaline phosphatase family
SRM_RS02080	COG3279	Response regulator of the LytR AlgR family
SRM_RS02085	COG3275	phosphorelay sensor kinase activity
SRM_RS02110	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SRM_RS02130	COG0095	Lipoate-protein ligase
SRM_RS02165	COG2072	flavoprotein involved in K transport
SRM_RS02175	COG1629	transport
SRM_RS02190	COG4771	TonB-dependent receptor
SRM_RS02235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SRM_RS02250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SRM_RS02285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SRM_RS02320	COG0438	transferase activity, transferring glycosyl groups
SRM_RS02350	COG0596	Alpha beta hydrolase
SRM_RS02365	COG1705	Flagellar rod assembly protein muramidase FlgJ
SRM_RS02365	COG1388	LysM domain
SRM_RS02370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SRM_RS02380	COG1137	ATPase activity
SRM_RS02405	COG0514	ATP-dependent DNA helicase (RecQ)
SRM_RS02420	COG0527	aspartate kinase activity
SRM_RS02435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SRM_RS02445	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SRM_RS02450	COG0823	Involved in the tonB-independent uptake of proteins
SRM_RS02450	COG1506	peptidase
SRM_RS02450	COG4946	Tricorn protease homolog
SRM_RS02455	COG4263	nitrous-oxide reductase activity
SRM_RS02470	COG1131	(ABC) transporter
SRM_RS02505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SRM_RS02515	COG2188	Transcriptional regulator
SRM_RS02520	COG1252	NADH dehydrogenase
SRM_RS02580	COG0783	Belongs to the Dps family
SRM_RS02600	COG2205	protein histidine kinase activity
SRM_RS02620	COG1968	undecaprenyl-diphosphatase activity
SRM_RS02635	COG1160	GTP binding
SRM_RS02655	COG1127	ABC transporter
SRM_RS02660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SRM_RS02675	COG0673	inositol 2-dehydrogenase activity
SRM_RS02690	COG1510	regulation of RNA biosynthetic process
SRM_RS02700	COG1629	transport
SRM_RS02705	COG5002	protein histidine kinase activity
SRM_RS02710	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SRM_RS02720	COG1629	transport
SRM_RS02720	COG4206	TonB-dependent receptor
SRM_RS02725	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SRM_RS02745	COG1629	transport
SRM_RS02775	COG1472	Belongs to the glycosyl hydrolase 3 family
SRM_RS02780	COG2971	BadF BadG BcrA BcrD
SRM_RS02830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRM_RS02840	COG0174	glutamine synthetase
SRM_RS02845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SRM_RS02850	COG3387	PFAM Glycoside hydrolase 15-related
SRM_RS02880	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SRM_RS02885	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SRM_RS02895	COG0649	NAD binding
SRM_RS02900	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SRM_RS02915	COG1034	ATP synthesis coupled electron transport
SRM_RS02930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SRM_RS02930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SRM_RS02935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SRM_RS02940	COG0481	GTPase activity
SRM_RS02950	COG0681	Belongs to the peptidase S26 family
SRM_RS02960	COG0475	glutathione-regulated potassium exporter activity
SRM_RS02960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SRM_RS02985	COG0154	amidase activity
SRM_RS02990	COG3275	phosphorelay sensor kinase activity
SRM_RS02995	COG3279	Response regulator of the LytR AlgR family
SRM_RS03025	COG0175	sulfate reduction
SRM_RS03030	COG0674	pyruvate-flavodoxin oxidoreductase activity
SRM_RS03030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SRM_RS03035	COG1013	pyruvate-flavodoxin oxidoreductase activity
SRM_RS03055	COG0693	protein deglycase activity
SRM_RS03070	COG3448	diguanylate cyclase activity
SRM_RS03070	COG4175	Glycine betaine
SRM_RS03075	COG4176	ABC-type proline glycine betaine transport system permease component
SRM_RS03085	COG2113	Glycine betaine
SRM_RS03100	COG2814	Major facilitator Superfamily
SRM_RS03130	COG0438	transferase activity, transferring glycosyl groups
SRM_RS03160	COG2133	pyrroloquinoline quinone binding
SRM_RS03180	COG2195	Cleaves the N-terminal amino acid of tripeptides
SRM_RS03190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SRM_RS03200	COG0632	four-way junction helicase activity
SRM_RS03220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SRM_RS03235	COG1217	gtp-binding protein TYPA
SRM_RS03245	COG0484	heat shock protein binding
SRM_RS03250	COG0439	Biotin carboxylase
SRM_RS03260	COG2205	protein histidine kinase activity
SRM_RS03260	COG0784	Response regulator, receiver
SRM_RS03300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SRM_RS03305	COG2873	o-acetylhomoserine
SRM_RS03310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SRM_RS03315	COG0527	aspartate kinase activity
SRM_RS03320	COG0460	homoserine dehydrogenase
SRM_RS03320	COG0527	aspartate kinase activity
SRM_RS03330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SRM_RS03335	COG1053	succinate dehydrogenase
SRM_RS03345	COG2009	succinate dehydrogenase
SRM_RS03350	COG0372	Belongs to the citrate synthase family
SRM_RS03365	COG0321	lipoyl(octanoyl) transferase activity
SRM_RS03365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SRM_RS03375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SRM_RS03385	COG0728	peptidoglycan biosynthetic process
SRM_RS03390	COG1678	Uncharacterized ACR, COG1678
SRM_RS03435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SRM_RS03440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SRM_RS03450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SRM_RS03450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SRM_RS03465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SRM_RS03475	COG0210	DNA helicase
SRM_RS03480	COG1192	Involved in chromosome partitioning
SRM_RS03485	COG1475	DNA binding
SRM_RS03495	COG0156	8-amino-7-oxononanoate synthase activity
SRM_RS03500	COG0456	acetyltransferase
SRM_RS03515	COG0047	phosphoribosylformylglycinamidine synthase activity
SRM_RS03530	COG0629	single-stranded DNA binding
SRM_RS03535	COG2267	carboxylic ester hydrolase activity
SRM_RS03545	COG3022	response to hydroperoxide
SRM_RS03550	COG0572	uridine kinase
SRM_RS03555	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SRM_RS03570	COG0483	inositol monophosphate 1-phosphatase activity
SRM_RS03575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SRM_RS03595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SRM_RS03605	COG0210	DNA helicase
SRM_RS03635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SRM_RS03655	COG0259	pyridoxamine-phosphate oxidase activity
SRM_RS03665	COG0506	proline dehydrogenase activity
SRM_RS03670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SRM_RS03675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SRM_RS03685	COG0504	CTP synthase activity
SRM_RS03695	COG2001	Belongs to the MraZ family
SRM_RS03700	COG0275	rRNA processing
SRM_RS03715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SRM_RS03720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SRM_RS03725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SRM_RS03730	COG0772	Belongs to the SEDS family
SRM_RS03735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SRM_RS03740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SRM_RS03745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SRM_RS03770	COG0438	transferase activity, transferring glycosyl groups
SRM_RS03800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SRM_RS03800	COG0561	phosphatase activity
SRM_RS03815	COG0584	glycerophosphoryl diester phosphodiesterase
SRM_RS03825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SRM_RS03830	COG0745	RESPONSE REGULATOR receiver
SRM_RS03835	COG5002	protein histidine kinase activity
SRM_RS03840	COG0022	dehydrogenase e1 component
SRM_RS03865	COG2895	sulfate adenylyltransferase (ATP) activity
SRM_RS03865	COG0529	Catalyzes the synthesis of activated sulfate
SRM_RS03880	COG3273	potassium ion transport
SRM_RS03880	COG0471	metal ion transport
SRM_RS03905	COG1088	dTDP-glucose 4,6-dehydratase activity
SRM_RS03945	COG1132	(ABC) transporter
SRM_RS03950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRM_RS03955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SRM_RS03960	COG2089	acid synthase
SRM_RS03965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SRM_RS03970	COG2089	acid synthase
SRM_RS03980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SRM_RS04010	COG0438	transferase activity, transferring glycosyl groups
SRM_RS04070	COG2361	Protein of unknown function DUF86
SRM_RS04090	COG2002	toxin-antitoxin pair type II binding
SRM_RS04200	COG3311	Transcriptional regulator
SRM_RS04310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRM_RS04335	COG3093	addiction module antidote protein HigA
SRM_RS04425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRM_RS04440	COG0077	Prephenate dehydratase
SRM_RS04440	COG1605	Chorismate mutase
SRM_RS04455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SRM_RS04460	COG1193	negative regulation of DNA recombination
SRM_RS04475	COG5000	phosphorelay sensor kinase activity
SRM_RS04480	COG0501	Belongs to the peptidase M48B family
SRM_RS04530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SRM_RS04535	COG0101	tRNA pseudouridine synthase activity
SRM_RS04545	COG2235	arginine
SRM_RS04550	COG0492	ferredoxin-NADP+ reductase activity
SRM_RS04560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SRM_RS04565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SRM_RS04570	COG0154	amidase activity
SRM_RS04575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SRM_RS04585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SRM_RS04600	COG0589	response to stress
SRM_RS04605	COG2197	response regulator
SRM_RS04625	COG0039	L-malate dehydrogenase activity
SRM_RS04630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SRM_RS04665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SRM_RS04680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SRM_RS04685	COG3599	regulation of cell shape
SRM_RS04690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SRM_RS04700	COG0577	efflux transmembrane transporter activity
SRM_RS04705	COG1956	GAF domain-containing protein
SRM_RS04725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SRM_RS04730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SRM_RS04785	COG1063	alcohol dehydrogenase
SRM_RS04805	COG0629	single-stranded DNA binding
SRM_RS04810	COG2986	histidine ammonia-lyase
SRM_RS04815	COG0210	DNA helicase
SRM_RS04840	COG1090	epimerase
SRM_RS04845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRM_RS04850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRM_RS04855	COG1538	Outer membrane efflux protein
SRM_RS04860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SRM_RS04865	COG0140	phosphoribosyl-ATP diphosphatase activity
SRM_RS04895	COG0300	oxidoreductase activity
SRM_RS04910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SRM_RS04915	COG3001	Fructosamine kinase
SRM_RS04945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SRM_RS04960	COG3279	Response regulator of the LytR AlgR family
SRM_RS04965	COG3275	phosphorelay sensor kinase activity
SRM_RS04975	COG1131	(ABC) transporter
SRM_RS05000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SRM_RS05015	COG5002	protein histidine kinase activity
SRM_RS05025	COG3335	DDE superfamily endonuclease
SRM_RS05040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SRM_RS05040	COG0519	Catalyzes the synthesis of GMP from XMP
SRM_RS05045	COG0424	maF-like protein
SRM_RS05050	COG1192	Involved in chromosome partitioning
SRM_RS05060	COG0733	neurotransmitter:sodium symporter activity
SRM_RS05065	COG1473	amidohydrolase
SRM_RS05080	COG2850	peptidyl-arginine hydroxylation
SRM_RS05105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SRM_RS05110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SRM_RS05115	COG0805	protein transport
SRM_RS05120	COG0793	Belongs to the peptidase S41A family
SRM_RS05130	COG2226	methyltransferase
SRM_RS05145	COG0589	response to stress
SRM_RS05155	COG1940	carbohydrate kinase activity
SRM_RS05165	COG0148	phosphopyruvate hydratase activity
SRM_RS05185	COG0297	glycogen (starch) synthase activity
SRM_RS05190	COG4133	protoheme IX ABC transporter activity
SRM_RS05210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SRM_RS05220	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SRM_RS05230	COG0497	DNA recombination
SRM_RS05235	COG0653	protein targeting
SRM_RS05240	COG0589	response to stress
SRM_RS05245	COG4974	Belongs to the 'phage' integrase family
SRM_RS05255	COG0598	Magnesium transport protein CorA
SRM_RS05285	COG3273	potassium ion transport
SRM_RS05285	COG0471	metal ion transport
SRM_RS05290	COG0508	dehydrogenase complex catalyzes the overall conversion of
SRM_RS05295	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SRM_RS05300	COG0193	aminoacyl-tRNA hydrolase activity
SRM_RS05305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SRM_RS05310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SRM_RS05335	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SRM_RS05340	COG0489	protein tyrosine kinase activity
SRM_RS05350	COG2264	protein methyltransferase activity
SRM_RS05355	COG2226	methyltransferase
SRM_RS05365	COG0205	6-phosphofructokinase activity
SRM_RS05375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SRM_RS05380	COG0511	ligase activity, forming carbon-carbon bonds
SRM_RS05385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRM_RS05400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SRM_RS05410	COG5002	protein histidine kinase activity
SRM_RS05410	COG2205	protein histidine kinase activity
SRM_RS05410	COG0784	Response regulator, receiver
SRM_RS05420	COG2205	protein histidine kinase activity
SRM_RS05425	COG0745	RESPONSE REGULATOR receiver
SRM_RS05440	COG0124	histidyl-tRNA synthetase
SRM_RS05455	COG0492	ferredoxin-NADP+ reductase activity
SRM_RS05470	COG4772	TonB-dependent receptor
SRM_RS05480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SRM_RS05490	COG0366	Alpha amylase catalytic
SRM_RS05520	COG0569	domain protein
SRM_RS05565	COG0363	glucosamine-6-phosphate deaminase activity
SRM_RS05570	COG5002	protein histidine kinase activity
SRM_RS05575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SRM_RS05585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SRM_RS05610	COG2202	Pas domain
SRM_RS05610	COG2205	protein histidine kinase activity
SRM_RS05615	COG0596	Alpha beta hydrolase
SRM_RS05620	COG2378	regulation of single-species biofilm formation
SRM_RS05640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SRM_RS05645	COG4221	oxidoreductase activity
SRM_RS05655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SRM_RS05670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SRM_RS05670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SRM_RS05680	COG2323	membrane
SRM_RS05700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SRM_RS05710	COG1196	nuclear chromosome segregation
SRM_RS05715	COG0668	transmembrane transport
SRM_RS05720	COG5002	protein histidine kinase activity
SRM_RS05745	COG0405	Gamma-glutamyltransferase
SRM_RS05755	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SRM_RS05765	COG0733	neurotransmitter:sodium symporter activity
SRM_RS05770	COG0733	neurotransmitter:sodium symporter activity
SRM_RS05780	COG0686	Belongs to the AlaDH PNT family
SRM_RS05795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SRM_RS05805	COG0268	Binds directly to 16S ribosomal RNA
SRM_RS05830	COG0356	it plays a direct role in the translocation of protons across the membrane
SRM_RS05835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SRM_RS05840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SRM_RS05845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SRM_RS05850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SRM_RS05855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SRM_RS05865	COG0702	epimerase
SRM_RS05890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SRM_RS05895	COG1253	flavin adenine dinucleotide binding
SRM_RS05925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SRM_RS05935	COG2897	thiosulfate sulfurtransferase activity
SRM_RS05945	COG0495	leucyl-tRNA aminoacylation
SRM_RS05950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SRM_RS05955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SRM_RS05960	COG0511	ligase activity, forming carbon-carbon bonds
SRM_RS05965	COG0439	Biotin carboxylase
SRM_RS05970	COG0436	Aminotransferase
SRM_RS06000	COG0823	Involved in the tonB-independent uptake of proteins
SRM_RS06000	COG1506	peptidase
SRM_RS06000	COG4946	Tricorn protease homolog
SRM_RS06010	COG0596	Alpha beta hydrolase
SRM_RS06045	COG1192	Involved in chromosome partitioning
SRM_RS06055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SRM_RS06060	COG1428	Deoxynucleoside kinase
SRM_RS06075	COG0505	Belongs to the CarA family
SRM_RS06080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SRM_RS06090	COG0688	phosphatidylethanolamine metabolic process
SRM_RS06095	COG1183	phosphatidylcholine synthase activity
SRM_RS06100	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SRM_RS06130	COG2171	N-acyltransferase activity
SRM_RS06135	COG0358	DNA primase activity
SRM_RS06145	COG0519	Catalyzes the synthesis of GMP from XMP
SRM_RS06160	COG0519	Catalyzes the synthesis of GMP from XMP
SRM_RS06160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SRM_RS06190	COG1070	Carbohydrate kinase
SRM_RS06205	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SRM_RS06215	COG0018	arginyl-trna synthetase
SRM_RS06230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SRM_RS06235	COG2897	thiosulfate sulfurtransferase activity
SRM_RS06245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SRM_RS06260	COG0702	epimerase
SRM_RS06285	COG1132	(ABC) transporter
SRM_RS06295	COG1215	transferase activity, transferring glycosyl groups
SRM_RS06325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SRM_RS06330	COG2884	Cell division ATP-binding protein ftsE
SRM_RS06350	COG1404	Belongs to the peptidase S8 family
SRM_RS06360	COG0113	porphobilinogen synthase activity
SRM_RS06365	COG0215	cysteine-tRNA ligase activity
SRM_RS06380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SRM_RS06385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SRM_RS06390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SRM_RS06395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SRM_RS06410	COG0702	epimerase
SRM_RS06430	COG0517	IMP dehydrogenase activity
SRM_RS06430	COG1994	Peptidase M50
SRM_RS06435	COG0469	pyruvate kinase activity
SRM_RS06450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SRM_RS06455	COG0049	tRNA binding
SRM_RS06460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SRM_RS06465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SRM_RS06470	COG0051	transcription antitermination factor activity, RNA binding
SRM_RS06475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SRM_RS06480	COG0088	Forms part of the polypeptide exit tunnel
SRM_RS06485	COG0089	rRNA binding
SRM_RS06490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SRM_RS06495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SRM_RS06500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SRM_RS06505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SRM_RS06510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SRM_RS06515	COG0255	Belongs to the universal ribosomal protein uL29 family
SRM_RS06520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SRM_RS06525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SRM_RS06530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SRM_RS06535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SRM_RS06540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SRM_RS06545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SRM_RS06550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SRM_RS06555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SRM_RS06560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SRM_RS06565	COG0200	Binds to the 23S rRNA
SRM_RS06575	COG0024	Methionine aminopeptidase
SRM_RS06580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SRM_RS06585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SRM_RS06590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SRM_RS06595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SRM_RS06600	COG0202	RNA polymerase activity
SRM_RS06605	COG0203	ribosomal protein L17
SRM_RS06610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SRM_RS06620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SRM_RS06635	COG0613	PHP domain protein
SRM_RS06640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SRM_RS06665	COG1040	competence protein
SRM_RS06670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SRM_RS06675	COG0105	UTP biosynthetic process
SRM_RS06680	COG3876	Protein conserved in bacteria
SRM_RS06700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SRM_RS06705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SRM_RS06715	COG0415	Belongs to the DNA photolyase family
SRM_RS06750	COG3956	TIGRFAM MazG family protein
SRM_RS06770	COG1960	acyl-CoA dehydrogenase activity
SRM_RS06775	COG0783	Belongs to the Dps family
SRM_RS06780	COG1754	DNA topoisomerase type I activity
SRM_RS06780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SRM_RS06785	COG1162	GTPase activity
SRM_RS06800	COG4191	Histidine kinase
SRM_RS06800	COG0784	Response regulator, receiver
SRM_RS06815	COG0045	succinate-CoA ligase (ADP-forming) activity
SRM_RS06825	COG1228	amidohydrolase
SRM_RS06830	COG1228	amidohydrolase
SRM_RS06835	COG2091	lysine biosynthetic process via aminoadipic acid
SRM_RS06850	COG1509	lysine 2,3-aminomutase activity
SRM_RS06855	COG2442	InterPro IPR007367
SRM_RS06865	COG1181	Belongs to the D-alanine--D-alanine ligase family
SRM_RS06875	COG1757	Na H antiporter
SRM_RS06880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SRM_RS06880	COG0574	Belongs to the PEP-utilizing enzyme family
SRM_RS06890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SRM_RS06900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SRM_RS06925	COG2255	four-way junction helicase activity
SRM_RS06930	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SRM_RS06940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SRM_RS06945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SRM_RS06965	COG1214	PFAM Peptidase M22, glycoprotease
SRM_RS06970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SRM_RS06995	COG0556	nucleotide-excision repair
SRM_RS07000	COG0626	cystathionine gamma-synthase activity
SRM_RS07005	COG0254	rRNA binding
SRM_RS07010	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SRM_RS07035	COG0315	cyclic pyranopterin monophosphate synthase activity
SRM_RS07040	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SRM_RS07045	COG0069	glutamate synthase activity
SRM_RS07045	COG0067	glutamate synthase
SRM_RS07045	COG0070	glutamate synthase
SRM_RS07055	COG1490	D-aminoacyl-tRNA deacylase activity
SRM_RS07060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SRM_RS07065	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SRM_RS07070	COG0567	Dehydrogenase, E1 component
SRM_RS07070	COG0508	dehydrogenase complex catalyzes the overall conversion of
SRM_RS07080	COG0745	RESPONSE REGULATOR receiver
SRM_RS07095	COG1381	Involved in DNA repair and RecF pathway recombination
SRM_RS07110	COG0415	Belongs to the DNA photolyase family
SRM_RS07135	COG1739	Uncharacterized protein family UPF0029
SRM_RS07140	COG0328	RNA-DNA hybrid ribonuclease activity
SRM_RS07145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SRM_RS07150	COG0758	DNA mediated transformation
SRM_RS07165	COG0564	pseudouridine synthase activity
SRM_RS07215	COG1131	(ABC) transporter
SRM_RS07220	COG0668	transmembrane transport
SRM_RS07225	COG0126	phosphoglycerate kinase activity
SRM_RS07245	COG1136	(ABC) transporter
SRM_RS07255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SRM_RS07275	COG1022	Amp-dependent synthetase and ligase
SRM_RS07280	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRM_RS07280	COG1024	Enoyl-CoA hydratase
SRM_RS07285	COG0183	Belongs to the thiolase family
SRM_RS07290	COG4221	oxidoreductase activity
SRM_RS07295	COG1960	acyl-CoA dehydrogenase activity
SRM_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
SRM_RS07330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRM_RS07345	COG1272	protein, Hemolysin III
SRM_RS07350	COG1234	tRNA 3'-trailer cleavage
SRM_RS07360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SRM_RS07365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SRM_RS07370	COG2204	response regulator
SRM_RS07375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SRM_RS07380	COG1012	belongs to the aldehyde dehydrogenase family
SRM_RS07400	COG0076	glutamate decarboxylase activity
SRM_RS07405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRM_RS07405	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SRM_RS07410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRM_RS07410	COG2022	thiamine diphosphate biosynthetic process
SRM_RS07420	COG2022	thiamine diphosphate biosynthetic process
SRM_RS07425	COG0352	thiamine-phosphate diphosphorylase activity
SRM_RS07430	COG0351	phosphomethylpyrimidine kinase
SRM_RS07445	COG2205	protein histidine kinase activity
SRM_RS07445	COG0784	Response regulator, receiver
SRM_RS07465	COG0612	Peptidase, M16
SRM_RS07470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRM_RS07495	COG1131	(ABC) transporter
SRM_RS07500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SRM_RS07505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SRM_RS07525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SRM_RS07525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SRM_RS07535	COG0076	glutamate decarboxylase activity
SRM_RS07540	COG2814	Major facilitator Superfamily
SRM_RS07560	COG1295	ribonuclease BN
SRM_RS07570	COG1428	Deoxynucleoside kinase
SRM_RS07580	COG0656	L-ascorbic acid biosynthetic process
SRM_RS07585	COG1104	cysteine desulfurase activity
SRM_RS07590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SRM_RS07610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SRM_RS07650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SRM_RS07675	COG1115	amino acid carrier protein
SRM_RS07680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SRM_RS07690	COG1757	Na H antiporter
SRM_RS07695	COG0662	Cupin 2, conserved barrel domain protein
SRM_RS07695	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SRM_RS07700	COG0242	peptide deformylase activity
SRM_RS07710	COG1120	ATPase activity
SRM_RS07730	COG4772	TonB-dependent receptor
SRM_RS07735	COG2385	sporulation resulting in formation of a cellular spore
SRM_RS07740	COG0084	hydrolase, TatD family'
SRM_RS07750	COG0443	Heat shock 70 kDa protein
SRM_RS07755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SRM_RS07760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SRM_RS07765	COG1058	Belongs to the CinA family
SRM_RS07765	COG1546	Belongs to the CinA family
SRM_RS07770	COG4221	oxidoreductase activity
SRM_RS07770	COG0604	alcohol dehydrogenase
SRM_RS07770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SRM_RS07770	COG3321	synthase
SRM_RS07775	COG1764	response to oxidative stress
SRM_RS07780	COG0668	transmembrane transport
SRM_RS07805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SRM_RS07810	COG3118	belongs to the thioredoxin family
SRM_RS07825	COG0589	response to stress
SRM_RS07830	COG0589	response to stress
SRM_RS07840	COG0542	response to heat
SRM_RS07845	COG0316	Belongs to the HesB IscA family
SRM_RS07870	COG0590	tRNA wobble adenosine to inosine editing
SRM_RS07880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SRM_RS07900	COG0475	glutathione-regulated potassium exporter activity
SRM_RS07905	COG0577	efflux transmembrane transporter activity
SRM_RS07925	COG0540	Belongs to the ATCase OTCase family
SRM_RS07930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SRM_RS07945	COG0628	permease
SRM_RS07970	COG0571	ribonuclease III activity
SRM_RS07975	COG1012	belongs to the aldehyde dehydrogenase family
SRM_RS07985	COG0697	spore germination
SRM_RS08000	COG0406	alpha-ribazole phosphatase activity
SRM_RS08005	COG1169	isochorismate synthase
SRM_RS08010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SRM_RS08015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SRM_RS08025	COG1441	menaquinone biosynthetic process
SRM_RS08040	COG0745	RESPONSE REGULATOR receiver
SRM_RS08065	COG1137	ATPase activity
SRM_RS08070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SRM_RS08075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SRM_RS08080	COG0360	Binds together with S18 to 16S ribosomal RNA
SRM_RS08085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SRM_RS08090	COG0359	binds to the 23S rRNA
SRM_RS08095	COG0626	cystathionine gamma-synthase activity
SRM_RS08100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SRM_RS08105	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SRM_RS08115	COG0604	alcohol dehydrogenase
SRM_RS08120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRM_RS08140	COG0776	regulation of translation
SRM_RS08160	COG2204	response regulator
SRM_RS08165	COG2151	metal-sulfur cluster biosynthetic enzyme
SRM_RS08170	COG2166	iron-sulfur cluster assembly
SRM_RS08180	COG0719	Fe-S assembly protein
SRM_RS08185	COG0396	ATPase activity
SRM_RS08190	COG0719	Fe-S assembly protein
SRM_RS08195	COG0316	Belongs to the HesB IscA family
SRM_RS08215	COG0456	acetyltransferase
SRM_RS08220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SRM_RS08245	COG1473	amidohydrolase
SRM_RS08295	COG1132	(ABC) transporter
SRM_RS08300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SRM_RS08305	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SRM_RS08310	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRM_RS08315	COG1702	phosphate starvation-inducible protein PhoH
SRM_RS08320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SRM_RS08325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SRM_RS08330	COG3228	Belongs to the MtfA family
SRM_RS08335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SRM_RS08340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SRM_RS08345	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SRM_RS08350	COG0179	Fumarylacetoacetate (FAA) hydrolase
SRM_RS08365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SRM_RS08370	COG1619	proteins homologs of microcin C7 resistance protein MccF
SRM_RS08380	COG1215	transferase activity, transferring glycosyl groups
SRM_RS08395	COG1562	ergosterol biosynthetic process
SRM_RS08410	COG0717	Belongs to the dCTP deaminase family
SRM_RS08420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SRM_RS08440	COG0740	serine-type endopeptidase activity
SRM_RS08445	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SRM_RS08455	COG0248	Ppx GppA phosphatase
SRM_RS08460	COG0839	Belongs to the complex I subunit 6 family
SRM_RS08465	COG0713	ATP synthesis coupled electron transport
SRM_RS08470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SRM_RS08480	COG2154	pterin-4-alpha-carbinolamine dehydratase
SRM_RS08485	COG1007	ATP synthesis coupled electron transport
SRM_RS08495	COG2204	response regulator
SRM_RS08520	COG0515	serine threonine protein kinase
SRM_RS08520	COG2815	serine threonine protein kinase
SRM_RS08530	COG1335	isochorismatase
SRM_RS08550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SRM_RS08555	COG0840	transmembrane signaling receptor activity
SRM_RS08560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SRM_RS08600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SRM_RS08605	COG2169	Transcriptional regulator
SRM_RS08605	COG1917	Cupin 2, conserved barrel domain protein
SRM_RS08610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SRM_RS08615	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SRM_RS08625	COG1024	Enoyl-CoA hydratase
SRM_RS08630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SRM_RS08635	COG1562	ergosterol biosynthetic process
SRM_RS08640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SRM_RS08645	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SRM_RS08650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SRM_RS08660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SRM_RS08665	COG0187	DNA topoisomerase II activity
SRM_RS08715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SRM_RS08720	COG1187	pseudouridine synthase activity
SRM_RS08725	COG0516	GMP reductase activity
SRM_RS08725	COG0517	IMP dehydrogenase activity
SRM_RS08730	COG0006	proline dipeptidase activity
SRM_RS08740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SRM_RS08765	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SRM_RS08775	COG4974	Belongs to the 'phage' integrase family
SRM_RS08785	COG4974	Belongs to the 'phage' integrase family
SRM_RS08805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SRM_RS08805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SRM_RS08815	COG1609	Transcriptional regulator
SRM_RS08820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SRM_RS08825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SRM_RS08830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SRM_RS08840	COG1012	belongs to the aldehyde dehydrogenase family
SRM_RS08855	COG1480	7TM receptor with intracellular HD hydrolase
SRM_RS08880	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SRM_RS08885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SRM_RS08895	COG0557	exoribonuclease II activity
SRM_RS08910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SRM_RS08950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SRM_RS08975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SRM_RS08980	COG2094	Belongs to the DNA glycosylase MPG family
SRM_RS08990	COG0183	Belongs to the thiolase family
SRM_RS08995	COG1331	Highly conserved protein containing a thioredoxin domain
SRM_RS09005	COG2379	hydroxypyruvate reductase
SRM_RS09015	COG0352	thiamine-phosphate diphosphorylase activity
SRM_RS09025	COG0181	hydroxymethylbilane synthase activity
SRM_RS09030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SRM_RS09035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SRM_RS09040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SRM_RS09040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SRM_RS09050	COG0131	Imidazoleglycerol-phosphate dehydratase
SRM_RS09055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SRM_RS09060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SRM_RS09070	COG1278	Cold shock
SRM_RS09075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SRM_RS09080	COG0107	imidazoleglycerol-phosphate synthase activity
SRM_RS09110	COG0039	L-malate dehydrogenase activity
SRM_RS09115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SRM_RS09125	COG0667	Aldo Keto reductase
SRM_RS09140	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SRM_RS09155	COG0322	excinuclease ABC activity
SRM_RS09200	COG0811	peptide transport
SRM_RS09225	COG2226	methyltransferase
SRM_RS09250	COG0644	oxidoreductase
SRM_RS09255	COG0009	L-threonylcarbamoyladenylate synthase
SRM_RS09260	COG3339	Conserved Protein
SRM_RS09270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SRM_RS09270	COG0617	tRNA 3'-terminal CCA addition
SRM_RS09270	COG0517	IMP dehydrogenase activity
SRM_RS09290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SRM_RS09305	COG0484	heat shock protein binding
SRM_RS09310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SRM_RS09330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SRM_RS09340	COG0114	fumarate hydratase activity
SRM_RS09345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRM_RS09365	COG0287	Prephenate dehydrogenase
SRM_RS09370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SRM_RS09380	COG1674	ftsk spoiiie
SRM_RS09390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SRM_RS09400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SRM_RS09405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SRM_RS09415	COG0335	large ribosomal subunit rRNA binding
SRM_RS09420	COG0336	Belongs to the RNA methyltransferase TrmD family
SRM_RS09425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SRM_RS09430	COG0228	four-way junction DNA binding
SRM_RS09435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SRM_RS09455	COG0612	Peptidase, M16
SRM_RS09460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SRM_RS09460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SRM_RS09470	COG2202	Pas domain
SRM_RS09470	COG2205	protein histidine kinase activity
SRM_RS09475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SRM_RS09480	COG0138	bifunctional purine biosynthesis protein purh
SRM_RS09495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SRM_RS09505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SRM_RS09515	COG1073	alpha beta
SRM_RS09520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SRM_RS09540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SRM_RS09545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SRM_RS09550	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SRM_RS09565	COG3344	reverse transcriptase
SRM_RS09580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SRM_RS09590	COG3174	membrane
SRM_RS09615	COG0180	Tryptophanyl-tRNA synthetase
SRM_RS09620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SRM_RS09620	COG0512	Glutamine amidotransferase of anthranilate synthase
SRM_RS09625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SRM_RS09630	COG0134	indole-3-glycerol-phosphate synthase activity
SRM_RS09635	COG0135	phosphoribosylanthranilate isomerase activity
SRM_RS09640	COG0133	tryptophan synthase activity
SRM_RS09645	COG0159	tryptophan synthase activity
SRM_RS09660	COG0514	ATP-dependent DNA helicase (RecQ)
SRM_RS09665	COG1215	transferase activity, transferring glycosyl groups
SRM_RS09680	COG0473	3-isopropylmalate dehydrogenase activity
SRM_RS09690	COG0848	biopolymer transport protein
SRM_RS09700	COG0811	peptide transport
SRM_RS09705	COG1796	DNA polymerase
SRM_RS09705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SRM_RS09715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SRM_RS09720	COG0512	Glutamine amidotransferase of anthranilate synthase
SRM_RS09720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SRM_RS09725	COG0604	alcohol dehydrogenase
SRM_RS09730	COG1902	pentaerythritol trinitrate reductase activity
SRM_RS09745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRM_RS09745	COG1703	isobutyryl-CoA mutase activity
SRM_RS09745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRM_RS09755	COG1863	multisubunit Na H antiporter MnhE subunit
SRM_RS09760	COG0651	ATP synthesis coupled electron transport
SRM_RS09765	COG1006	Multisubunit Na H antiporter MnhC subunit
SRM_RS09770	COG2111	Na H antiporter
SRM_RS09775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SRM_RS09775	COG2111	Na H antiporter
SRM_RS09780	COG1320	monovalent cation:proton antiporter activity
SRM_RS09815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SRM_RS09830	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SRM_RS09835	COG1078	dGTPase activity
SRM_RS09845	COG3033	Beta-eliminating lyase
SRM_RS09850	COG0252	asparaginase activity
SRM_RS09860	COG0037	tRNA processing
SRM_RS09865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SRM_RS09875	COG0575	Belongs to the CDS family
SRM_RS09910	COG0534	Mate efflux family protein
SRM_RS09915	COG4191	Histidine kinase
SRM_RS09920	COG2204	response regulator
SRM_RS09930	COG1136	(ABC) transporter
SRM_RS09930	COG0577	efflux transmembrane transporter activity
SRM_RS09935	COG1136	(ABC) transporter
SRM_RS09935	COG4591	ABC-type transport system involved in lipoprotein release permease component
SRM_RS09940	COG1136	(ABC) transporter
SRM_RS09940	COG0577	efflux transmembrane transporter activity
SRM_RS10005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SRM_RS10010	COG1960	acyl-CoA dehydrogenase activity
SRM_RS10015	COG0284	orotidine-5'-phosphate decarboxylase activity
SRM_RS10030	COG0589	response to stress
SRM_RS10040	COG0477	Major facilitator Superfamily
SRM_RS10045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SRM_RS10055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SRM_RS10060	COG0408	coproporphyrinogen oxidase activity
SRM_RS10065	COG0564	pseudouridine synthase activity
SRM_RS10075	COG0528	UMP kinase activity
SRM_RS10080	COG2715	membrane protein required for spore maturation
SRM_RS10085	COG0700	Nucleoside recognition
SRM_RS10090	COG2027	D-alanyl-D-alanine carboxypeptidase
SRM_RS10095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRM_RS10135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SRM_RS10140	COG0085	RNA polymerase activity
SRM_RS10145	COG0222	ribosome binding
SRM_RS10150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SRM_RS10155	COG0081	regulation of translation
SRM_RS10160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SRM_RS10165	COG0250	Participates in transcription elongation, termination and antitermination
SRM_RS10180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SRM_RS10185	COG0471	metal ion transport
SRM_RS10185	COG3273	potassium ion transport
SRM_RS10210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SRM_RS10215	COG1185	polyribonucleotide nucleotidyltransferase activity
SRM_RS10220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SRM_RS10225	COG0196	riboflavin kinase activity
SRM_RS10230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SRM_RS10235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SRM_RS10235	COG3064	Membrane
SRM_RS10240	COG0195	Participates in both transcription termination and antitermination
SRM_RS10240	COG2251	uridine kinase activity
SRM_RS10245	COG0779	Required for maturation of 30S ribosomal subunits
SRM_RS10250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SRM_RS10255	COG0436	Aminotransferase
SRM_RS10285	COG0539	negative regulation of cytoplasmic translation
SRM_RS10290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SRM_RS10300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SRM_RS10305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRM_RS10310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRM_RS10310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRM_RS10325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SRM_RS10325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SRM_RS10330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SRM_RS10345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SRM_RS10350	COG0714	Associated with various cellular activities
SRM_RS10375	COG0006	proline dipeptidase activity
SRM_RS10380	COG1074	ATP-dependent DNA helicase activity
SRM_RS10385	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SRM_RS10440	COG0530	calcium, potassium:sodium antiporter activity
SRM_RS10455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SRM_RS10465	COG0792	nuclease activity
SRM_RS10485	COG2205	protein histidine kinase activity
SRM_RS10490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SRM_RS10495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SRM_RS10500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SRM_RS10510	COG2267	carboxylic ester hydrolase activity
SRM_RS10520	COG0017	Asparaginyl-tRNA synthetase
SRM_RS10530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SRM_RS10550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SRM_RS10555	COG0668	transmembrane transport
SRM_RS10565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SRM_RS10570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SRM_RS10590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SRM_RS10600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SRM_RS10630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SRM_RS10635	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SRM_RS10645	COG1104	cysteine desulfurase activity
SRM_RS10650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SRM_RS10670	COG0151	Belongs to the GarS family
SRM_RS10690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SRM_RS10700	COG0419	ATPase involved in DNA repair
SRM_RS10715	COG1610	YqeY-like protein
SRM_RS10725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SRM_RS10735	COG0563	adenylate kinase activity
SRM_RS10760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SRM_RS10765	COG2226	methyltransferase
SRM_RS10770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRM_RS10790	COG0523	cobalamin synthesis protein
SRM_RS10795	COG4771	TonB-dependent receptor
SRM_RS10875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SRM_RS10885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SRM_RS10900	COG0149	triose-phosphate isomerase activity
SRM_RS10905	COG1830	Aldolase
SRM_RS10920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SRM_RS10925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SRM_RS10930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SRM_RS10945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SRM_RS10990	COG3335	DDE superfamily endonuclease
SRM_RS11030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SRM_RS11035	COG0297	glycogen (starch) synthase activity
SRM_RS11060	COG1595	DNA-templated transcription, initiation
SRM_RS11075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SRM_RS11095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SRM_RS11100	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SRM_RS11110	COG0793	Belongs to the peptidase S41A family
SRM_RS11120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SRM_RS11125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SRM_RS11140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SRM_RS11165	COG2177	Part of the ABC transporter FtsEX involved in
SRM_RS11175	COG0071	Belongs to the small heat shock protein (HSP20) family
SRM_RS11200	COG0756	dUTP diphosphatase activity
SRM_RS11210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SRM_RS11225	COG0022	dehydrogenase e1 component
SRM_RS11240	COG0508	dehydrogenase complex catalyzes the overall conversion of
SRM_RS11245	COG0022	dehydrogenase e1 component
SRM_RS11245	COG0508	dehydrogenase complex catalyzes the overall conversion of
SRM_RS11250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SRM_RS11255	COG0463	Glycosyl transferase, family 2
SRM_RS11260	COG0538	isocitrate dehydrogenase activity
SRM_RS11265	COG0494	nUDIX hydrolase
SRM_RS11330	COG0589	response to stress
SRM_RS11345	COG3591	Belongs to the peptidase S1B family
SRM_RS11365	COG1366	Belongs to the anti-sigma-factor antagonist family
SRM_RS11365	COG2202	Pas domain
SRM_RS11400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SRM_RS11420	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SRM_RS11435	COG2382	esterase
SRM_RS11460	COG3335	DDE superfamily endonuclease
SRM_RS11490	COG0191	fructose-bisphosphate aldolase activity
SRM_RS11495	COG2222	sugar isomerase
SRM_RS11515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SRM_RS11520	COG1629	transport
SRM_RS11535	COG0530	calcium, potassium:sodium antiporter activity
SRM_RS11575	COG0823	Involved in the tonB-independent uptake of proteins
SRM_RS11575	COG1506	peptidase
SRM_RS11575	COG4946	Tricorn protease homolog
SRM_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
SRM_RS11595	COG3046	protein related to deoxyribodipyrimidine photolyase
SRM_RS11600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SRM_RS11610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SRM_RS11625	COG0525	valine-tRNA ligase activity
SRM_RS11630	COG1321	iron dependent repressor
SRM_RS11695	COG3002	Belongs to the UPF0753 family
SRM_RS11700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SRM_RS11705	COG5609	conserved protein (DUF2294)
SRM_RS11710	COG0484	heat shock protein binding
SRM_RS11715	COG1233	COG1233 Phytoene dehydrogenase and related
SRM_RS11730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SRM_RS11735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRM_RS11740	COG5002	protein histidine kinase activity
SRM_RS11745	COG0123	including yeast histone deacetylase and acetoin utilization protein
SRM_RS11750	COG2890	protein-(glutamine-N5) methyltransferase activity
SRM_RS11755	COG1254	Belongs to the acylphosphatase family
SRM_RS11775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SRM_RS11790	COG0519	Catalyzes the synthesis of GMP from XMP
SRM_RS11790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SRM_RS11795	COG0509	glycine decarboxylation via glycine cleavage system
SRM_RS11800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SRM_RS11805	COG0742	ribosomal rna small subunit methyltransferase
SRM_RS11820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SRM_RS11825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SRM_RS11830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SRM_RS11845	COG0438	transferase activity, transferring glycosyl groups
SRM_RS11850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SRM_RS11875	COG1278	Cold shock
SRM_RS11880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SRM_RS11890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SRM_RS11950	COG0437	4 iron, 4 sulfur cluster binding
SRM_RS11980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SRM_RS11995	COG0494	nUDIX hydrolase
SRM_RS12040	COG0459	protein refolding
SRM_RS12065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SRM_RS12070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SRM_RS12075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SRM_RS12085	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SRM_RS12100	COG0628	permease
SRM_RS12105	COG2137	regulation of response to DNA damage stimulus
SRM_RS12135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SRM_RS12140	COG1138	Cytochrome C-type biogenesis protein
SRM_RS12150	COG0028	Belongs to the TPP enzyme family
SRM_RS12155	COG0440	acetolactate synthase activity
SRM_RS12160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SRM_RS12165	COG0473	3-isopropylmalate dehydrogenase activity
SRM_RS12175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SRM_RS12185	COG0066	3-isopropylmalate dehydratase activity
SRM_RS12190	COG0129	dihydroxy-acid dehydratase activity
SRM_RS12195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRM_RS12210	COG3118	belongs to the thioredoxin family
SRM_RS12225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SRM_RS12240	COG1132	(ABC) transporter
SRM_RS12245	COG1234	tRNA 3'-trailer cleavage
SRM_RS12250	COG1132	(ABC) transporter
SRM_RS12265	COG0739	heme binding
SRM_RS12270	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SRM_RS12275	COG0714	Associated with various cellular activities
SRM_RS12280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SRM_RS12285	COG0552	protein localization to endoplasmic reticulum
SRM_RS12290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SRM_RS12310	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SRM_RS12320	COG1629	transport
SRM_RS12325	COG3695	enzyme binding
SRM_RS12335	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SRM_RS12340	COG1629	transport
SRM_RS12345	COG3695	enzyme binding
SRM_RS12350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SRM_RS12375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SRM_RS12395	COG2239	Acts as a magnesium transporter
SRM_RS12400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SRM_RS12415	COG1181	Belongs to the D-alanine--D-alanine ligase family
SRM_RS12420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SRM_RS12440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SRM_RS12445	COG4181	ATPase activity
SRM_RS12470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SRM_RS12475	COG1047	Peptidyl-prolyl cis-trans
SRM_RS12480	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SRM_RS12505	COG0137	argininosuccinate synthase activity
SRM_RS12515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SRM_RS12520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SRM_RS12525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SRM_RS12530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SRM_RS12535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRM_RS12540	COG0165	Argininosuccinate lyase
SRM_RS12545	COG0861	Integral membrane protein TerC family
SRM_RS12560	COG1615	UPF0182 protein
SRM_RS12570	COG2226	methyltransferase
SRM_RS12580	COG0330	HflC and HflK could
SRM_RS12590	COG1496	oxidoreductase activity
SRM_RS12600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SRM_RS12600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SRM_RS12605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SRM_RS12610	COG0793	Belongs to the peptidase S41A family
SRM_RS12610	COG4946	Tricorn protease homolog
SRM_RS12615	COG0546	phosphoglycolate phosphatase activity
SRM_RS12660	COG2827	Endonuclease containing a URI domain
SRM_RS12665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRM_RS12675	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SRM_RS12700	COG1082	Xylose isomerase domain protein TIM barrel
SRM_RS12710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SRM_RS12715	COG3263	regulation of cellular component size
SRM_RS12725	COG0531	amino acid
SRM_RS12750	COG0531	amino acid
SRM_RS12760	COG0490	domain, Protein
SRM_RS12760	COG0471	metal ion transport
SRM_RS12765	COG0569	domain protein
SRM_RS12770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SRM_RS12775	COG0569	domain protein
SRM_RS12780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SRM_RS12785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SRM_RS12785	COG4651	solute:proton antiporter activity
SRM_RS12795	COG0531	amino acid
SRM_RS12800	COG0531	amino acid
SRM_RS12805	COG2202	Pas domain
SRM_RS12805	COG2205	protein histidine kinase activity
SRM_RS12810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SRM_RS12840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SRM_RS12840	COG0517	IMP dehydrogenase activity
SRM_RS12860	COG1309	transcriptional regulator
SRM_RS12865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SRM_RS12870	COG1061	Type III restriction enzyme res subunit
SRM_RS12885	COG0745	RESPONSE REGULATOR receiver
SRM_RS12890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SRM_RS12895	COG0573	inorganic phosphate transmembrane transporter activity
SRM_RS12900	COG0581	inorganic phosphate transmembrane transporter activity
SRM_RS12905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SRM_RS12910	COG0704	Plays a role in the regulation of phosphate uptake
SRM_RS12940	COG0307	riboflavin synthase, alpha
SRM_RS12965	COG0477	Major facilitator Superfamily
SRM_RS12990	COG0531	amino acid
SRM_RS13000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SRM_RS13005	COG0210	DNA helicase
SRM_RS13010	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SRM_RS13015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SRM_RS13060	COG3275	phosphorelay sensor kinase activity
SRM_RS13065	COG3279	Response regulator of the LytR AlgR family
SRM_RS13080	COG0415	Belongs to the DNA photolyase family
SRM_RS13100	COG0423	glycine-tRNA ligase activity
SRM_RS13110	COG2003	Belongs to the UPF0758 family
SRM_RS13115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SRM_RS13125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SRM_RS13135	COG0346	lactoylglutathione lyase activity
SRM_RS13140	COG0123	including yeast histone deacetylase and acetoin utilization protein
SRM_RS13155	COG0825	malonyl-CoA metabolic process
SRM_RS13170	COG0484	heat shock protein binding
SRM_RS13175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SRM_RS13180	COG1420	regulation of RNA biosynthetic process
SRM_RS13185	COG0616	signal peptide processing
SRM_RS13190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SRM_RS13195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SRM_RS13210	COG0071	Belongs to the small heat shock protein (HSP20) family
SRM_RS13230	COG0626	cystathionine gamma-synthase activity
SRM_RS13260	COG0109	protoheme IX farnesyltransferase activity
SRM_RS13270	COG0842	Transport permease protein
SRM_RS13275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SRM_RS13280	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SRM_RS13290	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SRM_RS13300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SRM_RS13320	COG0167	dihydroorotate dehydrogenase activity
SRM_RS13325	COG0384	phenazine biosynthesis protein PhzF
SRM_RS13335	COG0768	penicillin binding
SRM_RS13340	COG0772	Belongs to the SEDS family
SRM_RS13345	COG0004	ammonium transporteR
SRM_RS13350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SRM_RS13355	COG3304	Inner membrane component domain
SRM_RS13390	COG0784	Response regulator, receiver
SRM_RS13390	COG2205	protein histidine kinase activity
SRM_RS13430	COG1840	ABC-type Fe3 transport system, periplasmic component
SRM_RS13440	COG0438	transferase activity, transferring glycosyl groups
SRM_RS13445	COG0667	Aldo Keto reductase
SRM_RS13455	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SRM_RS13465	COG0463	Glycosyl transferase, family 2
SRM_RS13470	COG0187	DNA topoisomerase II activity
SRM_RS13475	COG0366	Alpha amylase catalytic
SRM_RS13485	COG0517	IMP dehydrogenase activity
SRM_RS13490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SRM_RS13515	COG0802	atpase or kinase
SRM_RS13520	COG0285	dihydrofolate synthase activity
SRM_RS13525	COG0003	Pfam Anion-transporting ATPase
SRM_RS13535	COG1215	transferase activity, transferring glycosyl groups
SRM_RS13545	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SRM_RS13550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SRM_RS13565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SRM_RS13570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SRM_RS13575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SRM_RS13600	COG0617	tRNA 3'-terminal CCA addition
SRM_RS13615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SRM_RS13625	COG0517	IMP dehydrogenase activity
SRM_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
SRM_RS13670	COG4771	TonB-dependent receptor
SRM_RS13690	COG0402	S-adenosylhomocysteine deaminase activity
SRM_RS13695	COG1278	Cold shock
SRM_RS13705	COG0390	transport system, permease component
SRM_RS13710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SRM_RS13715	COG2259	Doxx family
SRM_RS13720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SRM_RS13730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SRM_RS13740	COG0798	PFAM Bile acid sodium symporter
SRM_RS13745	COG2226	methyltransferase
SRM_RS13750	COG0640	Transcriptional regulator
SRM_RS13800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SRM_RS13835	COG1131	(ABC) transporter
SRM_RS13860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SRM_RS13865	COG5002	protein histidine kinase activity
SRM_RS13870	COG0745	RESPONSE REGULATOR receiver
SRM_RS13875	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SRM_RS13880	COG1363	Peptidase, m42
SRM_RS13885	COG0745	RESPONSE REGULATOR receiver
SRM_RS13890	COG0745	RESPONSE REGULATOR receiver
SRM_RS13900	COG0482	sulfurtransferase activity
SRM_RS13905	COG0251	oxidation-reduction process
SRM_RS13915	COG0860	N-Acetylmuramoyl-L-alanine amidase
SRM_RS13930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SRM_RS13935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SRM_RS13940	COG1127	ABC transporter
SRM_RS13950	COG4399	Belongs to the UPF0754 family
SRM_RS13970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SRM_RS14015	COG2205	protein histidine kinase activity
SRM_RS14045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SRM_RS14065	COG0842	Transport permease protein
SRM_RS14065	COG1716	ATPase activity
SRM_RS14065	COG1131	(ABC) transporter
SRM_RS14090	COG0363	glucosamine-6-phosphate deaminase activity
SRM_RS14100	COG0673	inositol 2-dehydrogenase activity
SRM_RS14110	COG0673	inositol 2-dehydrogenase activity
SRM_RS14140	COG0442	prolyl-tRNA aminoacylation
SRM_RS14155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SRM_RS14160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SRM_RS14175	COG0799	negative regulation of ribosome biogenesis
SRM_RS14180	COG2363	Small membrane protein
SRM_RS14205	COG0321	lipoyl(octanoyl) transferase activity
SRM_RS14220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SRM_RS14225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SRM_RS14230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SRM_RS14240	COG1435	thymidine kinase activity
SRM_RS14255	COG2095	MarC family integral membrane protein
SRM_RS14260	COG0583	DNA-binding transcription factor activity
SRM_RS14300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SRM_RS14315	COG2205	protein histidine kinase activity
SRM_RS14315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SRM_RS14320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SRM_RS14345	COG0840	transmembrane signaling receptor activity
SRM_RS14350	COG1191	sigma factor activity
SRM_RS14370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SRM_RS14375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SRM_RS14380	COG1684	flagellar biosynthetic protein fliR
SRM_RS14385	COG1987	bacterial-type flagellum assembly
SRM_RS14390	COG1338	Plays a role in the flagellum-specific transport system
SRM_RS14400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SRM_RS14400	COG1776	CheC inhibitor of MCP methylation
SRM_RS14405	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SRM_RS14415	COG1360	Flagellar Motor Protein
SRM_RS14420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SRM_RS14425	COG0840	transmembrane signaling receptor activity
SRM_RS14450	COG0741	lytic transglycosylase activity
SRM_RS14455	COG2201	protein-glutamate methylesterase activity
SRM_RS14460	COG0784	Response regulator, receiver
SRM_RS14460	COG2198	Histidine kinase
SRM_RS14460	COG0643	Histidine kinase
SRM_RS14470	COG0745	RESPONSE REGULATOR receiver
SRM_RS14475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SRM_RS14480	COG0835	chemotaxis
SRM_RS14485	COG1749	Flagellar hook protein flgE
SRM_RS14495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SRM_RS14515	COG1157	protein secretion by the type III secretion system
SRM_RS14525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SRM_RS14555	COG3852	Histidine kinase
SRM_RS14560	COG2204	response regulator
SRM_RS14605	COG3335	DDE superfamily endonuclease
SRM_RS14615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SRM_RS14630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SRM_RS14635	COG4786	Flagellar basal body rod
SRM_RS14635	COG1256	bacterial-type flagellum assembly
SRM_RS14650	COG1706	bacterial-type flagellum-dependent cell motility
SRM_RS14665	COG4786	Flagellar basal body rod
SRM_RS14670	COG4786	Flagellar basal body rod
SRM_RS14700	COG1446	asparaginase
SRM_RS14720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SRM_RS14725	COG3118	belongs to the thioredoxin family
SRM_RS14735	COG1388	LysM domain
SRM_RS14735	COG0741	lytic transglycosylase activity
SRM_RS14740	COG0405	Gamma-glutamyltransferase
SRM_RS14775	COG0217	transcriptional regulatory protein
SRM_RS14780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SRM_RS14795	COG4152	abc transporter atp-binding protein
SRM_RS14800	COG1668	transmembrane transport
SRM_RS14805	COG0544	peptidyl-prolyl cis-trans isomerase activity
SRM_RS14810	COG0740	serine-type endopeptidase activity
SRM_RS14820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SRM_RS14830	COG1418	mRNA catabolic process
SRM_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
SRM_RS14850	COG2267	carboxylic ester hydrolase activity
SRM_RS14855	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
SRM_RS14870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SRM_RS14905	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SRM_RS14915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SRM_RS14945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SRM_RS14960	COG0668	transmembrane transport
SRM_RS14965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRM_RS14980	COG4232	protein-disulfide reductase activity
SRM_RS15055	COG3275	phosphorelay sensor kinase activity
SRM_RS15060	COG3279	Response regulator of the LytR AlgR family
SRM_RS15065	COG4771	TonB-dependent receptor
SRM_RS15070	COG4558	Periplasmic binding protein
SRM_RS15075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SRM_RS15080	COG2234	aminopeptidase activity
SRM_RS15085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SRM_RS15090	COG3720	iron ion transport
SRM_RS15105	COG4206	TonB-dependent receptor
SRM_RS15135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SRM_RS15140	COG2050	protein possibly involved in aromatic compounds catabolism
SRM_RS15145	COG0346	lactoylglutathione lyase activity
SRM_RS15170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SRM_RS15180	COG1643	Atp-dependent helicase
SRM_RS15185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SRM_RS15210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SRM_RS15215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SRM_RS15220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SRM_RS15255	COG1595	DNA-templated transcription, initiation
SRM_RS15290	COG0579	oxidoreductase
SRM_RS15300	COG0121	glutamine amidotransferase
SRM_RS15335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SRM_RS15340	COG1757	Na H antiporter
SRM_RS15345	COG4221	oxidoreductase activity
SRM_RS15360	COG4221	oxidoreductase activity
SRM_RS15375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SRM_RS15390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SRM_RS15400	COG2197	response regulator
SRM_RS15405	COG2197	response regulator
SRM_RS15410	COG5002	protein histidine kinase activity
SRM_RS15415	COG0237	dephospho-CoA kinase activity
SRM_RS15420	COG0537	adenosine 5'-monophosphoramidase activity
SRM_RS15430	COG0302	gtp cyclohydrolase
SRM_RS15450	COG0456	acetyltransferase
SRM_RS15460	COG1515	deoxyribonuclease V activity
SRM_RS15470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SRM_RS15475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SRM_RS15480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SRM_RS15485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SRM_RS15490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SRM_RS15495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SRM_RS15495	COG0072	phenylalanine-tRNA ligase activity
SRM_RS15510	COG0488	(ABC) transporter
SRM_RS15530	COG1228	amidohydrolase
SRM_RS15545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SRM_RS15550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SRM_RS15555	COG0116	Belongs to the methyltransferase superfamily
SRM_RS15590	COG0347	Belongs to the P(II) protein family
SRM_RS15605	COG0745	RESPONSE REGULATOR receiver
SRM_RS15610	COG5002	protein histidine kinase activity
SRM_RS15620	COG0542	response to heat
SRM_RS15640	COG1132	(ABC) transporter
SRM_RS15660	COG4771	TonB-dependent receptor
SRM_RS15680	COG1472	Belongs to the glycosyl hydrolase 3 family
SRM_RS15685	COG0477	Major facilitator Superfamily
SRM_RS15695	COG1136	(ABC) transporter
SRM_RS15710	COG0577	efflux transmembrane transporter activity
SRM_RS15735	COG3279	Response regulator of the LytR AlgR family
SRM_RS15740	COG3275	phosphorelay sensor kinase activity
SRM_RS15755	COG1629	transport
SRM_RS15755	COG4206	TonB-dependent receptor
SRM_RS15800	COG0346	lactoylglutathione lyase activity
SRM_RS15835	COG0706	membrane insertase activity
SRM_RS15890	COG1937	Protein conserved in bacteria
SRM_RS15900	COG5654	RES domain protein
SRM_RS15905	COG1215	transferase activity, transferring glycosyl groups
SRM_RS15960	COG0438	transferase activity, transferring glycosyl groups
SRM_RS15985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SRM_RS16005	COG1570	exodeoxyribonuclease VII activity
SRM_RS16040	COG0681	Belongs to the peptidase S26 family
SRM_RS16045	COG0295	cytidine deaminase activity
SRM_RS16050	COG0346	lactoylglutathione lyase activity
SRM_RS16075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity