locus-tag	class	description
DRG92_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DRG92_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
DRG92_RS00035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DRG92_RS00040	COG1937	Protein conserved in bacteria
DRG92_RS00060	COG1862	Preprotein translocase
DRG92_RS00065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DRG92_RS00065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DRG92_RS00075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DRG92_RS00080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DRG92_RS00085	COG0012	GTP binding
DRG92_RS00100	COG1809	phosphosulfolactate synthase activity
DRG92_RS00105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DRG92_RS00110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DRG92_RS00130	COG1573	uracil-dna glycosylase
DRG92_RS00145	COG0194	GDP metabolic process
DRG92_RS00150	COG1561	YicC-like family, N-terminal region
DRG92_RS00160	COG0233	cytoplasmic translational termination
DRG92_RS00165	COG0528	UMP kinase activity
DRG92_RS00170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DRG92_RS00175	COG0052	Belongs to the universal ribosomal protein uS2 family
DRG92_RS00180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DRG92_RS00185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DRG92_RS00195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DRG92_RS00200	COG0416	fatty acid biosynthetic process
DRG92_RS00205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DRG92_RS00210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DRG92_RS00275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DRG92_RS00280	COG0594	ribonuclease P activity
DRG92_RS00285	COG0706	membrane insertase activity
DRG92_RS00290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DRG92_RS00315	COG0445	tRNA wobble uridine modification
DRG92_RS00320	COG0357	Ribosomal RNA small subunit methyltransferase G
DRG92_RS00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DRG92_RS00355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DRG92_RS00370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DRG92_RS00450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DRG92_RS00455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DRG92_RS00460	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DRG92_RS00465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DRG92_RS00480	COG1309	transcriptional regulator
DRG92_RS00485	COG1538	Outer membrane efflux protein
DRG92_RS00505	COG2205	protein histidine kinase activity
DRG92_RS00515	COG4191	Histidine kinase
DRG92_RS00535	COG2205	protein histidine kinase activity
DRG92_RS00565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DRG92_RS00575	COG0501	Belongs to the peptidase M48B family
DRG92_RS00595	COG0640	Transcriptional regulator
DRG92_RS00620	COG1960	acyl-CoA dehydrogenase activity
DRG92_RS00690	COG0642	Histidine kinase
DRG92_RS00705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DRG92_RS00715	COG2807	transmembrane transport
DRG92_RS00775	COG0589	response to stress
DRG92_RS00780	COG0642	Histidine kinase
DRG92_RS00800	COG1131	(ABC) transporter
DRG92_RS00845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DRG92_RS00905	COG1629	transport
DRG92_RS00905	COG4206	TonB-dependent receptor
DRG92_RS00995	COG1462	curli production assembly transport component CsgG
DRG92_RS01080	COG1132	(ABC) transporter
DRG92_RS01130	COG1216	Glycosyl transferase, family 2
DRG92_RS01135	COG1216	Glycosyl transferase, family 2
DRG92_RS01160	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS01170	COG1216	Glycosyl transferase, family 2
DRG92_RS01210	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS01220	COG0110	maltose O-acetyltransferase activity
DRG92_RS01240	COG0367	asparagine synthase
DRG92_RS01255	COG0367	asparagine synthase
DRG92_RS01295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DRG92_RS01360	COG1785	Belongs to the alkaline phosphatase family
DRG92_RS01370	COG3279	Response regulator of the LytR AlgR family
DRG92_RS01375	COG3275	phosphorelay sensor kinase activity
DRG92_RS01395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DRG92_RS01415	COG0095	Lipoate-protein ligase
DRG92_RS01450	COG2072	flavoprotein involved in K transport
DRG92_RS01470	COG0784	Response regulator, receiver
DRG92_RS01470	COG2198	Histidine kinase
DRG92_RS01470	COG5002	protein histidine kinase activity
DRG92_RS01495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DRG92_RS01540	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS01550	COG3279	Response regulator of the LytR AlgR family
DRG92_RS01555	COG1088	dTDP-glucose 4,6-dehydratase activity
DRG92_RS01570	COG1091	dTDP-4-dehydrorhamnose reductase activity
DRG92_RS01620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DRG92_RS01635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DRG92_RS01665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DRG92_RS01675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DRG92_RS01695	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS01715	COG0596	Alpha beta hydrolase
DRG92_RS01730	COG1388	LysM domain
DRG92_RS01730	COG1705	Flagellar rod assembly protein muramidase FlgJ
DRG92_RS01735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DRG92_RS01745	COG1137	ATPase activity
DRG92_RS01770	COG0514	ATP-dependent DNA helicase (RecQ)
DRG92_RS01785	COG0527	aspartate kinase activity
DRG92_RS01800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DRG92_RS01810	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DRG92_RS01815	COG4946	Tricorn protease homolog
DRG92_RS01815	COG1506	peptidase
DRG92_RS01815	COG0823	Involved in the tonB-independent uptake of proteins
DRG92_RS01820	COG4263	nitrous-oxide reductase activity
DRG92_RS01865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DRG92_RS01875	COG2188	Transcriptional regulator
DRG92_RS01880	COG1252	NADH dehydrogenase
DRG92_RS01940	COG0783	Belongs to the Dps family
DRG92_RS01960	COG2205	protein histidine kinase activity
DRG92_RS01985	COG1968	undecaprenyl-diphosphatase activity
DRG92_RS02005	COG1160	GTP binding
DRG92_RS02025	COG1127	ABC transporter
DRG92_RS02030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DRG92_RS02045	COG0673	inositol 2-dehydrogenase activity
DRG92_RS02060	COG1510	regulation of RNA biosynthetic process
DRG92_RS02070	COG1629	transport
DRG92_RS02075	COG3850	Histidine kinase
DRG92_RS02075	COG3437	response regulator, receiver
DRG92_RS02075	COG2205	protein histidine kinase activity
DRG92_RS02075	COG4999	Histidine kinase
DRG92_RS02095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DRG92_RS02135	COG1629	transport
DRG92_RS02165	COG1472	Belongs to the glycosyl hydrolase 3 family
DRG92_RS02170	COG2971	BadF BadG BcrA BcrD
DRG92_RS02220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DRG92_RS02230	COG0174	glutamine synthetase
DRG92_RS02235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DRG92_RS02255	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DRG92_RS02260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DRG92_RS02270	COG0649	NAD binding
DRG92_RS02275	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DRG92_RS02290	COG1034	ATP synthesis coupled electron transport
DRG92_RS02310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DRG92_RS02310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DRG92_RS02315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DRG92_RS02320	COG0481	GTPase activity
DRG92_RS02330	COG0681	Belongs to the peptidase S26 family
DRG92_RS02340	COG0475	glutathione-regulated potassium exporter activity
DRG92_RS02340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DRG92_RS02365	COG0154	amidase activity
DRG92_RS02370	COG3275	phosphorelay sensor kinase activity
DRG92_RS02375	COG3279	Response regulator of the LytR AlgR family
DRG92_RS02405	COG0175	sulfate reduction
DRG92_RS02410	COG0674	pyruvate-flavodoxin oxidoreductase activity
DRG92_RS02410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DRG92_RS02415	COG1013	pyruvate-flavodoxin oxidoreductase activity
DRG92_RS02435	COG0693	protein deglycase activity
DRG92_RS02445	COG4175	Glycine betaine
DRG92_RS02445	COG3448	diguanylate cyclase activity
DRG92_RS02450	COG4176	ABC-type proline glycine betaine transport system permease component
DRG92_RS02460	COG2113	Glycine betaine
DRG92_RS02475	COG2814	Major facilitator Superfamily
DRG92_RS02480	COG4771	TonB-dependent receptor
DRG92_RS02505	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS02535	COG2133	pyrroloquinoline quinone binding
DRG92_RS02555	COG2195	Cleaves the N-terminal amino acid of tripeptides
DRG92_RS02565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DRG92_RS02575	COG0632	four-way junction helicase activity
DRG92_RS02595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DRG92_RS02610	COG1217	gtp-binding protein TYPA
DRG92_RS02620	COG0484	heat shock protein binding
DRG92_RS02625	COG0439	Biotin carboxylase
DRG92_RS02645	COG0784	Response regulator, receiver
DRG92_RS02645	COG2205	protein histidine kinase activity
DRG92_RS02685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DRG92_RS02690	COG2873	o-acetylhomoserine
DRG92_RS02695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DRG92_RS02700	COG0527	aspartate kinase activity
DRG92_RS02705	COG0527	aspartate kinase activity
DRG92_RS02705	COG0460	homoserine dehydrogenase
DRG92_RS02715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DRG92_RS02720	COG1053	succinate dehydrogenase
DRG92_RS02730	COG2009	succinate dehydrogenase
DRG92_RS02735	COG0372	Belongs to the citrate synthase family
DRG92_RS02750	COG0321	lipoyl(octanoyl) transferase activity
DRG92_RS02750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DRG92_RS02755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DRG92_RS02765	COG0728	peptidoglycan biosynthetic process
DRG92_RS02770	COG1678	Uncharacterized ACR, COG1678
DRG92_RS02815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DRG92_RS02820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DRG92_RS02830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DRG92_RS02830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DRG92_RS02845	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DRG92_RS02855	COG0210	DNA helicase
DRG92_RS02860	COG1192	Involved in chromosome partitioning
DRG92_RS02865	COG1475	DNA binding
DRG92_RS02875	COG0156	8-amino-7-oxononanoate synthase activity
DRG92_RS02880	COG0456	acetyltransferase
DRG92_RS02895	COG0047	phosphoribosylformylglycinamidine synthase activity
DRG92_RS02910	COG0629	single-stranded DNA binding
DRG92_RS02915	COG2267	carboxylic ester hydrolase activity
DRG92_RS02925	COG3022	response to hydroperoxide
DRG92_RS02930	COG0572	uridine kinase
DRG92_RS02935	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DRG92_RS02950	COG0483	inositol monophosphate 1-phosphatase activity
DRG92_RS02955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DRG92_RS02975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DRG92_RS02985	COG0210	DNA helicase
DRG92_RS02990	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DRG92_RS03010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DRG92_RS03020	COG0259	pyridoxamine-phosphate oxidase activity
DRG92_RS03030	COG0506	proline dehydrogenase activity
DRG92_RS03035	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DRG92_RS03040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DRG92_RS03050	COG0504	CTP synthase activity
DRG92_RS03060	COG2001	Belongs to the MraZ family
DRG92_RS03065	COG0275	rRNA processing
DRG92_RS03080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DRG92_RS03085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DRG92_RS03090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DRG92_RS03095	COG0772	Belongs to the SEDS family
DRG92_RS03100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DRG92_RS03105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DRG92_RS03110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DRG92_RS03140	COG0561	phosphatase activity
DRG92_RS03140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DRG92_RS03155	COG0584	glycerophosphoryl diester phosphodiesterase
DRG92_RS03165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DRG92_RS03170	COG0745	RESPONSE REGULATOR receiver
DRG92_RS03175	COG5002	protein histidine kinase activity
DRG92_RS03180	COG0022	dehydrogenase e1 component
DRG92_RS03220	COG0529	Catalyzes the synthesis of activated sulfate
DRG92_RS03220	COG2895	sulfate adenylyltransferase (ATP) activity
DRG92_RS03235	COG3273	potassium ion transport
DRG92_RS03235	COG0471	metal ion transport
DRG92_RS03265	COG1088	dTDP-glucose 4,6-dehydratase activity
DRG92_RS03290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DRG92_RS03295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DRG92_RS03325	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS03330	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS03400	COG0077	Prephenate dehydratase
DRG92_RS03400	COG1605	Chorismate mutase
DRG92_RS03410	COG0457	Tetratricopeptide repeat
DRG92_RS03415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DRG92_RS03420	COG1193	negative regulation of DNA recombination
DRG92_RS03435	COG5000	phosphorelay sensor kinase activity
DRG92_RS03440	COG0501	Belongs to the peptidase M48B family
DRG92_RS03490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DRG92_RS03495	COG0101	tRNA pseudouridine synthase activity
DRG92_RS03505	COG2235	arginine
DRG92_RS03510	COG0492	ferredoxin-NADP+ reductase activity
DRG92_RS03520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DRG92_RS03525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DRG92_RS03530	COG0154	amidase activity
DRG92_RS03535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DRG92_RS03545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DRG92_RS03555	COG0589	response to stress
DRG92_RS03560	COG2197	response regulator
DRG92_RS03580	COG0039	L-malate dehydrogenase activity
DRG92_RS03585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DRG92_RS03620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DRG92_RS03635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DRG92_RS03640	COG3599	regulation of cell shape
DRG92_RS03645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DRG92_RS03655	COG0577	efflux transmembrane transporter activity
DRG92_RS03660	COG1956	GAF domain-containing protein
DRG92_RS03675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DRG92_RS03730	COG1063	alcohol dehydrogenase
DRG92_RS03735	COG1063	alcohol dehydrogenase
DRG92_RS03755	COG0629	single-stranded DNA binding
DRG92_RS03760	COG2986	histidine ammonia-lyase
DRG92_RS03765	COG0210	DNA helicase
DRG92_RS03790	COG1090	epimerase
DRG92_RS03795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DRG92_RS03800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DRG92_RS03805	COG1538	Outer membrane efflux protein
DRG92_RS03810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DRG92_RS03815	COG0140	phosphoribosyl-ATP diphosphatase activity
DRG92_RS03845	COG0300	oxidoreductase activity
DRG92_RS03855	COG1570	exodeoxyribonuclease VII activity
DRG92_RS03860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DRG92_RS03865	COG3001	Fructosamine kinase
DRG92_RS03895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DRG92_RS03910	COG3279	Response regulator of the LytR AlgR family
DRG92_RS03915	COG3275	phosphorelay sensor kinase activity
DRG92_RS03925	COG1131	(ABC) transporter
DRG92_RS03950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DRG92_RS03965	COG5002	protein histidine kinase activity
DRG92_RS03980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DRG92_RS03980	COG0519	Catalyzes the synthesis of GMP from XMP
DRG92_RS03985	COG0424	maF-like protein
DRG92_RS03990	COG1192	Involved in chromosome partitioning
DRG92_RS04000	COG0733	neurotransmitter:sodium symporter activity
DRG92_RS04005	COG1473	amidohydrolase
DRG92_RS04025	COG2850	peptidyl-arginine hydroxylation
DRG92_RS04050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DRG92_RS04055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DRG92_RS04060	COG0805	protein transport
DRG92_RS04065	COG0793	Belongs to the peptidase S41A family
DRG92_RS04075	COG2226	methyltransferase
DRG92_RS04090	COG0589	response to stress
DRG92_RS04100	COG1940	carbohydrate kinase activity
DRG92_RS04110	COG0148	phosphopyruvate hydratase activity
DRG92_RS04130	COG0297	glycogen (starch) synthase activity
DRG92_RS04135	COG4133	protoheme IX ABC transporter activity
DRG92_RS04155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DRG92_RS04165	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DRG92_RS04175	COG0497	DNA recombination
DRG92_RS04180	COG0653	protein targeting
DRG92_RS04185	COG0589	response to stress
DRG92_RS04190	COG4974	Belongs to the 'phage' integrase family
DRG92_RS04200	COG0598	Magnesium transport protein CorA
DRG92_RS04230	COG3273	potassium ion transport
DRG92_RS04230	COG0471	metal ion transport
DRG92_RS04235	COG0508	dehydrogenase complex catalyzes the overall conversion of
DRG92_RS04240	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DRG92_RS04245	COG0193	aminoacyl-tRNA hydrolase activity
DRG92_RS04250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DRG92_RS04255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DRG92_RS04280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DRG92_RS04285	COG0489	protein tyrosine kinase activity
DRG92_RS04295	COG2264	protein methyltransferase activity
DRG92_RS04300	COG2226	methyltransferase
DRG92_RS04305	COG0205	6-phosphofructokinase activity
DRG92_RS04315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DRG92_RS04320	COG0511	ligase activity, forming carbon-carbon bonds
DRG92_RS04325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DRG92_RS04345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DRG92_RS04355	COG0784	Response regulator, receiver
DRG92_RS04355	COG2205	protein histidine kinase activity
DRG92_RS04355	COG5002	protein histidine kinase activity
DRG92_RS04365	COG2205	protein histidine kinase activity
DRG92_RS04365	COG0784	Response regulator, receiver
DRG92_RS04385	COG0124	histidyl-tRNA synthetase
DRG92_RS04400	COG0492	ferredoxin-NADP+ reductase activity
DRG92_RS04415	COG4772	TonB-dependent receptor
DRG92_RS04425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DRG92_RS04435	COG0366	Alpha amylase catalytic
DRG92_RS04465	COG0569	domain protein
DRG92_RS04510	COG0363	glucosamine-6-phosphate deaminase activity
DRG92_RS04515	COG5002	protein histidine kinase activity
DRG92_RS04520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DRG92_RS04530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DRG92_RS04555	COG2205	protein histidine kinase activity
DRG92_RS04555	COG2202	Pas domain
DRG92_RS04560	COG0596	Alpha beta hydrolase
DRG92_RS04565	COG2378	regulation of single-species biofilm formation
DRG92_RS04585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DRG92_RS04590	COG4221	oxidoreductase activity
DRG92_RS04600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DRG92_RS04625	COG2323	membrane
DRG92_RS04630	COG2361	Protein of unknown function DUF86
DRG92_RS04655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DRG92_RS04665	COG1196	nuclear chromosome segregation
DRG92_RS04670	COG0668	transmembrane transport
DRG92_RS04690	COG0405	Gamma-glutamyltransferase
DRG92_RS04700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DRG92_RS04710	COG0733	neurotransmitter:sodium symporter activity
DRG92_RS04715	COG0733	neurotransmitter:sodium symporter activity
DRG92_RS04725	COG0686	Belongs to the AlaDH PNT family
DRG92_RS04740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DRG92_RS04750	COG0268	Binds directly to 16S ribosomal RNA
DRG92_RS04775	COG0356	it plays a direct role in the translocation of protons across the membrane
DRG92_RS04780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DRG92_RS04785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DRG92_RS04790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DRG92_RS04795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DRG92_RS04800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DRG92_RS04810	COG0702	epimerase
DRG92_RS04835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DRG92_RS04845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DRG92_RS04850	COG1253	flavin adenine dinucleotide binding
DRG92_RS04875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DRG92_RS04885	COG2897	thiosulfate sulfurtransferase activity
DRG92_RS04895	COG0495	leucyl-tRNA aminoacylation
DRG92_RS04905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DRG92_RS04910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DRG92_RS04915	COG0511	ligase activity, forming carbon-carbon bonds
DRG92_RS04920	COG0439	Biotin carboxylase
DRG92_RS04925	COG0436	Aminotransferase
DRG92_RS04955	COG1506	peptidase
DRG92_RS04955	COG0823	Involved in the tonB-independent uptake of proteins
DRG92_RS04955	COG4946	Tricorn protease homolog
DRG92_RS04965	COG0596	Alpha beta hydrolase
DRG92_RS05000	COG1192	Involved in chromosome partitioning
DRG92_RS05010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DRG92_RS05015	COG1428	Deoxynucleoside kinase
DRG92_RS05030	COG0505	Belongs to the CarA family
DRG92_RS05035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DRG92_RS05045	COG0688	phosphatidylethanolamine metabolic process
DRG92_RS05050	COG1183	phosphatidylcholine synthase activity
DRG92_RS05055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DRG92_RS05085	COG2171	N-acyltransferase activity
DRG92_RS05090	COG0358	DNA primase activity
DRG92_RS05100	COG0519	Catalyzes the synthesis of GMP from XMP
DRG92_RS05115	COG0519	Catalyzes the synthesis of GMP from XMP
DRG92_RS05115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DRG92_RS05135	COG0587	DNA-directed DNA polymerase activity
DRG92_RS05145	COG1070	Carbohydrate kinase
DRG92_RS05160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DRG92_RS05170	COG0018	arginyl-trna synthetase
DRG92_RS05185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DRG92_RS05190	COG2897	thiosulfate sulfurtransferase activity
DRG92_RS05200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DRG92_RS05215	COG0702	epimerase
DRG92_RS05240	COG1132	(ABC) transporter
DRG92_RS05280	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DRG92_RS05285	COG2884	Cell division ATP-binding protein ftsE
DRG92_RS05305	COG1404	Belongs to the peptidase S8 family
DRG92_RS05315	COG0113	porphobilinogen synthase activity
DRG92_RS05320	COG0215	cysteine-tRNA ligase activity
DRG92_RS05335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DRG92_RS05340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DRG92_RS05345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DRG92_RS05350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DRG92_RS05365	COG0702	epimerase
DRG92_RS05385	COG0517	IMP dehydrogenase activity
DRG92_RS05385	COG1994	Peptidase M50
DRG92_RS05390	COG0469	pyruvate kinase activity
DRG92_RS05405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DRG92_RS05410	COG0049	tRNA binding
DRG92_RS05415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DRG92_RS05425	COG0051	transcription antitermination factor activity, RNA binding
DRG92_RS05430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DRG92_RS05435	COG0088	Forms part of the polypeptide exit tunnel
DRG92_RS05440	COG0089	rRNA binding
DRG92_RS05445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DRG92_RS05450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DRG92_RS05455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DRG92_RS05460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DRG92_RS05465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DRG92_RS05470	COG0255	Belongs to the universal ribosomal protein uL29 family
DRG92_RS05475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DRG92_RS05480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DRG92_RS05485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DRG92_RS05490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DRG92_RS05495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DRG92_RS05500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DRG92_RS05505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DRG92_RS05510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DRG92_RS05515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DRG92_RS05520	COG0200	Binds to the 23S rRNA
DRG92_RS05530	COG0024	Methionine aminopeptidase
DRG92_RS05535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DRG92_RS05540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DRG92_RS05545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DRG92_RS05550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DRG92_RS05555	COG0202	RNA polymerase activity
DRG92_RS05560	COG0203	ribosomal protein L17
DRG92_RS05565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DRG92_RS05575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DRG92_RS05590	COG0613	PHP domain protein
DRG92_RS05595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DRG92_RS05620	COG1040	competence protein
DRG92_RS05625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DRG92_RS05630	COG0105	UTP biosynthetic process
DRG92_RS05635	COG3876	Protein conserved in bacteria
DRG92_RS05655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DRG92_RS05660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DRG92_RS05670	COG0415	Belongs to the DNA photolyase family
DRG92_RS05725	COG3956	TIGRFAM MazG family protein
DRG92_RS05745	COG1960	acyl-CoA dehydrogenase activity
DRG92_RS05750	COG0783	Belongs to the Dps family
DRG92_RS05755	COG1754	DNA topoisomerase type I activity
DRG92_RS05755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DRG92_RS05760	COG1162	GTPase activity
DRG92_RS05775	COG4191	Histidine kinase
DRG92_RS05775	COG0784	Response regulator, receiver
DRG92_RS05790	COG0045	succinate-CoA ligase (ADP-forming) activity
DRG92_RS05800	COG1228	amidohydrolase
DRG92_RS05805	COG1228	amidohydrolase
DRG92_RS05810	COG2091	lysine biosynthetic process via aminoadipic acid
DRG92_RS05820	COG1509	lysine 2,3-aminomutase activity
DRG92_RS05825	COG2442	InterPro IPR007367
DRG92_RS05835	COG1181	Belongs to the D-alanine--D-alanine ligase family
DRG92_RS05845	COG1757	Na H antiporter
DRG92_RS05850	COG0574	Belongs to the PEP-utilizing enzyme family
DRG92_RS05850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DRG92_RS05855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DRG92_RS05865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DRG92_RS05890	COG2255	four-way junction helicase activity
DRG92_RS05895	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DRG92_RS05905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DRG92_RS05930	COG1214	PFAM Peptidase M22, glycoprotease
DRG92_RS05935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DRG92_RS05960	COG0556	nucleotide-excision repair
DRG92_RS05965	COG0626	cystathionine gamma-synthase activity
DRG92_RS05970	COG0254	rRNA binding
DRG92_RS05975	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DRG92_RS06000	COG0315	cyclic pyranopterin monophosphate synthase activity
DRG92_RS06005	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DRG92_RS06010	COG0070	glutamate synthase
DRG92_RS06010	COG0067	glutamate synthase
DRG92_RS06010	COG0069	glutamate synthase activity
DRG92_RS06020	COG1490	D-aminoacyl-tRNA deacylase activity
DRG92_RS06025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DRG92_RS06030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DRG92_RS06035	COG0567	Dehydrogenase, E1 component
DRG92_RS06035	COG0508	dehydrogenase complex catalyzes the overall conversion of
DRG92_RS06045	COG0745	RESPONSE REGULATOR receiver
DRG92_RS06060	COG1381	Involved in DNA repair and RecF pathway recombination
DRG92_RS06075	COG0415	Belongs to the DNA photolyase family
DRG92_RS06105	COG1739	Uncharacterized protein family UPF0029
DRG92_RS06110	COG0328	RNA-DNA hybrid ribonuclease activity
DRG92_RS06115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DRG92_RS06120	COG0758	DNA mediated transformation
DRG92_RS06130	COG0564	pseudouridine synthase activity
DRG92_RS06170	COG1131	(ABC) transporter
DRG92_RS06175	COG0668	transmembrane transport
DRG92_RS06180	COG0126	phosphoglycerate kinase activity
DRG92_RS06200	COG1136	(ABC) transporter
DRG92_RS06210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DRG92_RS06230	COG1022	Amp-dependent synthetase and ligase
DRG92_RS06235	COG1024	Enoyl-CoA hydratase
DRG92_RS06235	COG1250	3-hydroxyacyl-CoA dehydrogenase
DRG92_RS06240	COG0183	Belongs to the thiolase family
DRG92_RS06245	COG4221	oxidoreductase activity
DRG92_RS06250	COG1960	acyl-CoA dehydrogenase activity
DRG92_RS06255	COG1028	Short-chain dehydrogenase reductase Sdr
DRG92_RS06300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DRG92_RS06315	COG1272	protein, Hemolysin III
DRG92_RS06320	COG1234	tRNA 3'-trailer cleavage
DRG92_RS06330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DRG92_RS06335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DRG92_RS06340	COG2204	response regulator
DRG92_RS06345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DRG92_RS06350	COG1012	belongs to the aldehyde dehydrogenase family
DRG92_RS06365	COG0076	glutamate decarboxylase activity
DRG92_RS06370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DRG92_RS06370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DRG92_RS06375	COG2022	thiamine diphosphate biosynthetic process
DRG92_RS06375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DRG92_RS06385	COG2022	thiamine diphosphate biosynthetic process
DRG92_RS06390	COG0352	thiamine-phosphate diphosphorylase activity
DRG92_RS06395	COG0351	phosphomethylpyrimidine kinase
DRG92_RS06410	COG0784	Response regulator, receiver
DRG92_RS06410	COG2205	protein histidine kinase activity
DRG92_RS06430	COG0612	Peptidase, M16
DRG92_RS06435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DRG92_RS06460	COG1131	(ABC) transporter
DRG92_RS06465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DRG92_RS06470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DRG92_RS06490	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DRG92_RS06490	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DRG92_RS06500	COG0076	glutamate decarboxylase activity
DRG92_RS06505	COG2814	Major facilitator Superfamily
DRG92_RS06525	COG1295	ribonuclease BN
DRG92_RS06535	COG1428	Deoxynucleoside kinase
DRG92_RS06545	COG0656	L-ascorbic acid biosynthetic process
DRG92_RS06550	COG1104	cysteine desulfurase activity
DRG92_RS06555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DRG92_RS06580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DRG92_RS06630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DRG92_RS06655	COG1115	amino acid carrier protein
DRG92_RS06660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DRG92_RS06670	COG1757	Na H antiporter
DRG92_RS06675	COG0662	Cupin 2, conserved barrel domain protein
DRG92_RS06675	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DRG92_RS06680	COG0242	peptide deformylase activity
DRG92_RS06690	COG1120	ATPase activity
DRG92_RS06700	COG0739	heme binding
DRG92_RS06715	COG2385	sporulation resulting in formation of a cellular spore
DRG92_RS06720	COG0084	hydrolase, TatD family'
DRG92_RS06725	COG0443	Heat shock 70 kDa protein
DRG92_RS06730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DRG92_RS06735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DRG92_RS06740	COG1058	Belongs to the CinA family
DRG92_RS06740	COG1546	Belongs to the CinA family
DRG92_RS06745	COG1063	alcohol dehydrogenase
DRG92_RS06750	COG1764	response to oxidative stress
DRG92_RS06755	COG0668	transmembrane transport
DRG92_RS06780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DRG92_RS06785	COG3118	belongs to the thioredoxin family
DRG92_RS06800	COG0589	response to stress
DRG92_RS06805	COG0589	response to stress
DRG92_RS06815	COG0542	response to heat
DRG92_RS06820	COG0316	Belongs to the HesB IscA family
DRG92_RS06845	COG0590	tRNA wobble adenosine to inosine editing
DRG92_RS06855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DRG92_RS06875	COG0475	glutathione-regulated potassium exporter activity
DRG92_RS06875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DRG92_RS06880	COG0577	efflux transmembrane transporter activity
DRG92_RS06900	COG0540	Belongs to the ATCase OTCase family
DRG92_RS06905	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DRG92_RS06920	COG0628	permease
DRG92_RS06945	COG0571	ribonuclease III activity
DRG92_RS06950	COG1012	belongs to the aldehyde dehydrogenase family
DRG92_RS06960	COG0697	spore germination
DRG92_RS06975	COG0406	alpha-ribazole phosphatase activity
DRG92_RS06985	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DRG92_RS06990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DRG92_RS07000	COG1441	menaquinone biosynthetic process
DRG92_RS07005	COG0318	PFAM AMP-dependent synthetase and ligase
DRG92_RS07015	COG0745	RESPONSE REGULATOR receiver
DRG92_RS07040	COG1137	ATPase activity
DRG92_RS07045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DRG92_RS07050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DRG92_RS07055	COG0360	Binds together with S18 to 16S ribosomal RNA
DRG92_RS07060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DRG92_RS07065	COG0359	binds to the 23S rRNA
DRG92_RS07070	COG0626	cystathionine gamma-synthase activity
DRG92_RS07075	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DRG92_RS07080	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DRG92_RS07090	COG0604	alcohol dehydrogenase
DRG92_RS07095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DRG92_RS07110	COG0776	regulation of translation
DRG92_RS07130	COG2204	response regulator
DRG92_RS07135	COG2151	metal-sulfur cluster biosynthetic enzyme
DRG92_RS07140	COG2166	iron-sulfur cluster assembly
DRG92_RS07145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DRG92_RS07150	COG0719	Fe-S assembly protein
DRG92_RS07155	COG0396	ATPase activity
DRG92_RS07160	COG0719	Fe-S assembly protein
DRG92_RS07165	COG0316	Belongs to the HesB IscA family
DRG92_RS07185	COG0456	acetyltransferase
DRG92_RS07190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DRG92_RS07215	COG1473	amidohydrolase
DRG92_RS07260	COG1132	(ABC) transporter
DRG92_RS07265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DRG92_RS07270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DRG92_RS07275	COG1250	3-hydroxyacyl-CoA dehydrogenase
DRG92_RS07280	COG1702	phosphate starvation-inducible protein PhoH
DRG92_RS07285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DRG92_RS07290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DRG92_RS07295	COG3228	Belongs to the MtfA family
DRG92_RS07300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DRG92_RS07305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DRG92_RS07310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DRG92_RS07315	COG0179	Fumarylacetoacetate (FAA) hydrolase
DRG92_RS07330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DRG92_RS07335	COG1619	proteins homologs of microcin C7 resistance protein MccF
DRG92_RS07345	COG1215	transferase activity, transferring glycosyl groups
DRG92_RS07360	COG1562	ergosterol biosynthetic process
DRG92_RS07390	COG3335	DDE superfamily endonuclease
DRG92_RS07400	COG0717	Belongs to the dCTP deaminase family
DRG92_RS07410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DRG92_RS07430	COG0740	serine-type endopeptidase activity
DRG92_RS07435	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DRG92_RS07445	COG0248	Ppx GppA phosphatase
DRG92_RS07450	COG0839	Belongs to the complex I subunit 6 family
DRG92_RS07455	COG0713	ATP synthesis coupled electron transport
DRG92_RS07460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DRG92_RS07470	COG2154	pterin-4-alpha-carbinolamine dehydratase
DRG92_RS07475	COG1007	ATP synthesis coupled electron transport
DRG92_RS07485	COG2204	response regulator
DRG92_RS07510	COG0515	serine threonine protein kinase
DRG92_RS07510	COG2815	serine threonine protein kinase
DRG92_RS07520	COG1335	isochorismatase
DRG92_RS07530	COG1250	3-hydroxyacyl-CoA dehydrogenase
DRG92_RS07530	COG1024	Enoyl-CoA hydratase
DRG92_RS07540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DRG92_RS07545	COG0840	transmembrane signaling receptor activity
DRG92_RS07550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DRG92_RS07585	COG3842	ATPase activity
DRG92_RS07590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DRG92_RS07595	COG2169	Transcriptional regulator
DRG92_RS07595	COG1917	Cupin 2, conserved barrel domain protein
DRG92_RS07600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DRG92_RS07605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DRG92_RS07615	COG1024	Enoyl-CoA hydratase
DRG92_RS07620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DRG92_RS07625	COG1562	ergosterol biosynthetic process
DRG92_RS07630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DRG92_RS07635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DRG92_RS07640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DRG92_RS07650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DRG92_RS07655	COG0187	DNA topoisomerase II activity
DRG92_RS07685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DRG92_RS07690	COG1187	pseudouridine synthase activity
DRG92_RS07695	COG0517	IMP dehydrogenase activity
DRG92_RS07695	COG0516	GMP reductase activity
DRG92_RS07700	COG0006	proline dipeptidase activity
DRG92_RS07710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DRG92_RS07735	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DRG92_RS07755	COG4974	Belongs to the 'phage' integrase family
DRG92_RS07775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DRG92_RS07775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DRG92_RS07790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DRG92_RS07795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DRG92_RS07800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DRG92_RS07810	COG1012	belongs to the aldehyde dehydrogenase family
DRG92_RS07825	COG1480	7TM receptor with intracellular HD hydrolase
DRG92_RS07850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DRG92_RS07855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DRG92_RS07865	COG0557	exoribonuclease II activity
DRG92_RS07880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DRG92_RS07920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DRG92_RS07950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DRG92_RS07955	COG2094	Belongs to the DNA glycosylase MPG family
DRG92_RS07965	COG0183	Belongs to the thiolase family
DRG92_RS07970	COG1331	Highly conserved protein containing a thioredoxin domain
DRG92_RS07985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DRG92_RS07990	COG2379	hydroxypyruvate reductase
DRG92_RS08000	COG0352	thiamine-phosphate diphosphorylase activity
DRG92_RS08010	COG0181	hydroxymethylbilane synthase activity
DRG92_RS08015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DRG92_RS08020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DRG92_RS08025	COG3335	DDE superfamily endonuclease
DRG92_RS08030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DRG92_RS08030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DRG92_RS08040	COG0131	Imidazoleglycerol-phosphate dehydratase
DRG92_RS08045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DRG92_RS08080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DRG92_RS08090	COG1278	Cold shock
DRG92_RS08095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DRG92_RS08100	COG0107	imidazoleglycerol-phosphate synthase activity
DRG92_RS08130	COG0039	L-malate dehydrogenase activity
DRG92_RS08135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DRG92_RS08140	COG0346	lactoylglutathione lyase activity
DRG92_RS08145	COG0667	Aldo Keto reductase
DRG92_RS08160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DRG92_RS08175	COG0322	excinuclease ABC activity
DRG92_RS08220	COG0811	peptide transport
DRG92_RS08280	COG0644	oxidoreductase
DRG92_RS08285	COG0009	L-threonylcarbamoyladenylate synthase
DRG92_RS08290	COG3339	Conserved Protein
DRG92_RS08300	COG0617	tRNA 3'-terminal CCA addition
DRG92_RS08300	COG0517	IMP dehydrogenase activity
DRG92_RS08300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DRG92_RS08320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DRG92_RS08335	COG0484	heat shock protein binding
DRG92_RS08340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DRG92_RS08360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DRG92_RS08370	COG0114	fumarate hydratase activity
DRG92_RS08375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DRG92_RS08395	COG0287	Prephenate dehydrogenase
DRG92_RS08400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DRG92_RS08410	COG1674	ftsk spoiiie
DRG92_RS08420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DRG92_RS08430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DRG92_RS08435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DRG92_RS08445	COG0335	large ribosomal subunit rRNA binding
DRG92_RS08450	COG0336	Belongs to the RNA methyltransferase TrmD family
DRG92_RS08455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DRG92_RS08460	COG0228	four-way junction DNA binding
DRG92_RS08465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DRG92_RS08485	COG0612	Peptidase, M16
DRG92_RS08490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DRG92_RS08490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DRG92_RS08505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DRG92_RS08510	COG0138	bifunctional purine biosynthesis protein purh
DRG92_RS08525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DRG92_RS08535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DRG92_RS08550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DRG92_RS08570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DRG92_RS08575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DRG92_RS08580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DRG92_RS08600	COG3344	reverse transcriptase
DRG92_RS08605	COG0306	phosphate transporter
DRG92_RS08610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DRG92_RS08620	COG3174	membrane
DRG92_RS08645	COG0180	Tryptophanyl-tRNA synthetase
DRG92_RS08650	COG0512	Glutamine amidotransferase of anthranilate synthase
DRG92_RS08650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DRG92_RS08655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DRG92_RS08660	COG0134	indole-3-glycerol-phosphate synthase activity
DRG92_RS08665	COG0135	phosphoribosylanthranilate isomerase activity
DRG92_RS08670	COG0133	tryptophan synthase activity
DRG92_RS08675	COG0159	tryptophan synthase activity
DRG92_RS08690	COG0514	ATP-dependent DNA helicase (RecQ)
DRG92_RS08695	COG1215	transferase activity, transferring glycosyl groups
DRG92_RS08710	COG0473	3-isopropylmalate dehydrogenase activity
DRG92_RS08720	COG0848	biopolymer transport protein
DRG92_RS08730	COG0811	peptide transport
DRG92_RS08735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DRG92_RS08735	COG1796	DNA polymerase
DRG92_RS08745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DRG92_RS08750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DRG92_RS08750	COG0512	Glutamine amidotransferase of anthranilate synthase
DRG92_RS08755	COG0604	alcohol dehydrogenase
DRG92_RS08760	COG1902	pentaerythritol trinitrate reductase activity
DRG92_RS08775	COG1703	isobutyryl-CoA mutase activity
DRG92_RS08775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DRG92_RS08775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DRG92_RS08785	COG1863	multisubunit Na H antiporter MnhE subunit
DRG92_RS08790	COG0651	ATP synthesis coupled electron transport
DRG92_RS08795	COG1006	Multisubunit Na H antiporter MnhC subunit
DRG92_RS08800	COG2111	Na H antiporter
DRG92_RS08805	COG2111	Na H antiporter
DRG92_RS08805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DRG92_RS08810	COG1320	monovalent cation:proton antiporter activity
DRG92_RS08845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DRG92_RS08860	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DRG92_RS08865	COG1078	dGTPase activity
DRG92_RS08875	COG3033	Beta-eliminating lyase
DRG92_RS08880	COG0252	asparaginase activity
DRG92_RS08890	COG0037	tRNA processing
DRG92_RS08895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DRG92_RS08900	COG0575	Belongs to the CDS family
DRG92_RS08935	COG0534	Mate efflux family protein
DRG92_RS08940	COG4191	Histidine kinase
DRG92_RS08945	COG2204	response regulator
DRG92_RS08955	COG0577	efflux transmembrane transporter activity
DRG92_RS08955	COG1136	(ABC) transporter
DRG92_RS08960	COG1136	(ABC) transporter
DRG92_RS08960	COG4591	ABC-type transport system involved in lipoprotein release permease component
DRG92_RS08965	COG1136	(ABC) transporter
DRG92_RS08965	COG0577	efflux transmembrane transporter activity
DRG92_RS09030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DRG92_RS09035	COG1960	acyl-CoA dehydrogenase activity
DRG92_RS09040	COG0284	orotidine-5'-phosphate decarboxylase activity
DRG92_RS09055	COG0589	response to stress
DRG92_RS09065	COG0477	Major facilitator Superfamily
DRG92_RS09070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DRG92_RS09080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DRG92_RS09085	COG0408	coproporphyrinogen oxidase activity
DRG92_RS09090	COG0564	pseudouridine synthase activity
DRG92_RS09100	COG0528	UMP kinase activity
DRG92_RS09105	COG2715	membrane protein required for spore maturation
DRG92_RS09110	COG0700	Nucleoside recognition
DRG92_RS09115	COG2027	D-alanyl-D-alanine carboxypeptidase
DRG92_RS09120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DRG92_RS09160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DRG92_RS09165	COG0085	RNA polymerase activity
DRG92_RS09170	COG0222	ribosome binding
DRG92_RS09175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DRG92_RS09180	COG0081	regulation of translation
DRG92_RS09185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DRG92_RS09190	COG0250	Participates in transcription elongation, termination and antitermination
DRG92_RS09210	COG3273	potassium ion transport
DRG92_RS09210	COG0471	metal ion transport
DRG92_RS09235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DRG92_RS09240	COG1185	polyribonucleotide nucleotidyltransferase activity
DRG92_RS09245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DRG92_RS09250	COG0196	riboflavin kinase activity
DRG92_RS09255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DRG92_RS09260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DRG92_RS09260	COG3064	Membrane
DRG92_RS09265	COG0195	Participates in both transcription termination and antitermination
DRG92_RS09265	COG2251	uridine kinase activity
DRG92_RS09270	COG0779	Required for maturation of 30S ribosomal subunits
DRG92_RS09275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DRG92_RS09280	COG0436	Aminotransferase
DRG92_RS09310	COG0539	negative regulation of cytoplasmic translation
DRG92_RS09315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DRG92_RS09325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DRG92_RS09330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DRG92_RS09335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DRG92_RS09335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DRG92_RS09350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DRG92_RS09350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DRG92_RS09355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DRG92_RS09370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DRG92_RS09375	COG0714	Associated with various cellular activities
DRG92_RS09400	COG0006	proline dipeptidase activity
DRG92_RS09405	COG1074	ATP-dependent DNA helicase activity
DRG92_RS09410	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DRG92_RS09465	COG0530	calcium, potassium:sodium antiporter activity
DRG92_RS09480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DRG92_RS09490	COG0792	nuclease activity
DRG92_RS09510	COG2205	protein histidine kinase activity
DRG92_RS09515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DRG92_RS09520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DRG92_RS09525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DRG92_RS09535	COG2267	carboxylic ester hydrolase activity
DRG92_RS09545	COG0017	Asparaginyl-tRNA synthetase
DRG92_RS09555	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DRG92_RS09575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DRG92_RS09580	COG0668	transmembrane transport
DRG92_RS09590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DRG92_RS09595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DRG92_RS09615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DRG92_RS09625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DRG92_RS09655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DRG92_RS09660	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DRG92_RS09670	COG1104	cysteine desulfurase activity
DRG92_RS09675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DRG92_RS09690	COG0151	Belongs to the GarS family
DRG92_RS09710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DRG92_RS09720	COG0419	ATPase involved in DNA repair
DRG92_RS09730	COG1610	YqeY-like protein
DRG92_RS09740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DRG92_RS09750	COG0563	adenylate kinase activity
DRG92_RS09775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DRG92_RS09780	COG2226	methyltransferase
DRG92_RS09785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DRG92_RS09795	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DRG92_RS09800	COG0328	RNA-DNA hybrid ribonuclease activity
DRG92_RS09825	COG0523	cobalamin synthesis protein
DRG92_RS09905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DRG92_RS09915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DRG92_RS09930	COG0149	triose-phosphate isomerase activity
DRG92_RS09935	COG1830	Aldolase
DRG92_RS09950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DRG92_RS09955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DRG92_RS09960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DRG92_RS09975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DRG92_RS10050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DRG92_RS10055	COG0297	glycogen (starch) synthase activity
DRG92_RS10080	COG1595	DNA-templated transcription, initiation
DRG92_RS10100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DRG92_RS10120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DRG92_RS10125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DRG92_RS10135	COG0793	Belongs to the peptidase S41A family
DRG92_RS10145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DRG92_RS10150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DRG92_RS10165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DRG92_RS10190	COG2177	Part of the ABC transporter FtsEX involved in
DRG92_RS10200	COG0071	Belongs to the small heat shock protein (HSP20) family
DRG92_RS10225	COG0756	dUTP diphosphatase activity
DRG92_RS10235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DRG92_RS10250	COG0022	dehydrogenase e1 component
DRG92_RS10265	COG0508	dehydrogenase complex catalyzes the overall conversion of
DRG92_RS10270	COG0508	dehydrogenase complex catalyzes the overall conversion of
DRG92_RS10270	COG0022	dehydrogenase e1 component
DRG92_RS10275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DRG92_RS10280	COG0463	Glycosyl transferase, family 2
DRG92_RS10285	COG0538	isocitrate dehydrogenase activity
DRG92_RS10290	COG0494	nUDIX hydrolase
DRG92_RS10350	COG0589	response to stress
DRG92_RS10365	COG3591	Belongs to the peptidase S1B family
DRG92_RS10390	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DRG92_RS10395	COG2361	Protein of unknown function DUF86
DRG92_RS10425	COG4974	Belongs to the 'phage' integrase family
DRG92_RS10445	COG1366	Belongs to the anti-sigma-factor antagonist family
DRG92_RS10445	COG2202	Pas domain
DRG92_RS10480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DRG92_RS10500	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DRG92_RS10515	COG2382	esterase
DRG92_RS10575	COG0191	fructose-bisphosphate aldolase activity
DRG92_RS10580	COG2222	sugar isomerase
DRG92_RS10595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DRG92_RS10600	COG1629	transport
DRG92_RS10615	COG0530	calcium, potassium:sodium antiporter activity
DRG92_RS10650	COG4946	Tricorn protease homolog
DRG92_RS10650	COG1506	peptidase
DRG92_RS10650	COG0823	Involved in the tonB-independent uptake of proteins
DRG92_RS10660	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DRG92_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
DRG92_RS10670	COG3046	protein related to deoxyribodipyrimidine photolyase
DRG92_RS10675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DRG92_RS10685	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DRG92_RS10700	COG0525	valine-tRNA ligase activity
DRG92_RS10705	COG1321	iron dependent repressor
DRG92_RS10770	COG3002	Belongs to the UPF0753 family
DRG92_RS10775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DRG92_RS10780	COG5609	conserved protein (DUF2294)
DRG92_RS10785	COG0484	heat shock protein binding
DRG92_RS10790	COG1233	COG1233 Phytoene dehydrogenase and related
DRG92_RS10805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DRG92_RS10810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DRG92_RS10815	COG5002	protein histidine kinase activity
DRG92_RS10820	COG0123	including yeast histone deacetylase and acetoin utilization protein
DRG92_RS10825	COG2890	protein-(glutamine-N5) methyltransferase activity
DRG92_RS10830	COG1254	Belongs to the acylphosphatase family
DRG92_RS10850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DRG92_RS10865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DRG92_RS10865	COG0519	Catalyzes the synthesis of GMP from XMP
DRG92_RS10870	COG0509	glycine decarboxylation via glycine cleavage system
DRG92_RS10875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DRG92_RS10880	COG0742	ribosomal rna small subunit methyltransferase
DRG92_RS10885	COG3344	reverse transcriptase
DRG92_RS10905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DRG92_RS10910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DRG92_RS10915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DRG92_RS10930	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS10935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DRG92_RS10960	COG1278	Cold shock
DRG92_RS10965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DRG92_RS10975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DRG92_RS11035	COG0437	4 iron, 4 sulfur cluster binding
DRG92_RS11070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DRG92_RS11090	COG0494	nUDIX hydrolase
DRG92_RS11175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DRG92_RS11180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DRG92_RS11185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DRG92_RS11195	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DRG92_RS11210	COG0628	permease
DRG92_RS11215	COG2137	regulation of response to DNA damage stimulus
DRG92_RS11245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DRG92_RS11250	COG1138	Cytochrome C-type biogenesis protein
DRG92_RS11260	COG0028	Belongs to the TPP enzyme family
DRG92_RS11265	COG0440	acetolactate synthase activity
DRG92_RS11270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DRG92_RS11275	COG0473	3-isopropylmalate dehydrogenase activity
DRG92_RS11285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DRG92_RS11295	COG0066	3-isopropylmalate dehydratase activity
DRG92_RS11300	COG0129	dihydroxy-acid dehydratase activity
DRG92_RS11305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DRG92_RS11320	COG3118	belongs to the thioredoxin family
DRG92_RS11335	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DRG92_RS11350	COG1132	(ABC) transporter
DRG92_RS11355	COG1234	tRNA 3'-trailer cleavage
DRG92_RS11360	COG1132	(ABC) transporter
DRG92_RS11375	COG0739	heme binding
DRG92_RS11380	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DRG92_RS11385	COG0714	Associated with various cellular activities
DRG92_RS11390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DRG92_RS11395	COG0552	protein localization to endoplasmic reticulum
DRG92_RS11400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DRG92_RS11420	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DRG92_RS11430	COG1629	transport
DRG92_RS11435	COG3695	enzyme binding
DRG92_RS11445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DRG92_RS11450	COG1629	transport
DRG92_RS11465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DRG92_RS11475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DRG92_RS11510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DRG92_RS11530	COG2239	Acts as a magnesium transporter
DRG92_RS11535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DRG92_RS11550	COG1181	Belongs to the D-alanine--D-alanine ligase family
DRG92_RS11555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DRG92_RS11575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DRG92_RS11580	COG4181	ATPase activity
DRG92_RS11605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DRG92_RS11610	COG1047	Peptidyl-prolyl cis-trans
DRG92_RS11615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DRG92_RS11640	COG0137	argininosuccinate synthase activity
DRG92_RS11650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DRG92_RS11655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DRG92_RS11660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DRG92_RS11665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DRG92_RS11670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DRG92_RS11675	COG0165	Argininosuccinate lyase
DRG92_RS11680	COG0861	Integral membrane protein TerC family
DRG92_RS11695	COG1615	UPF0182 protein
DRG92_RS11705	COG2226	methyltransferase
DRG92_RS11715	COG0330	HflC and HflK could
DRG92_RS11725	COG1496	oxidoreductase activity
DRG92_RS11735	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DRG92_RS11735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DRG92_RS11740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DRG92_RS11745	COG0793	Belongs to the peptidase S41A family
DRG92_RS11745	COG4946	Tricorn protease homolog
DRG92_RS11750	COG0546	phosphoglycolate phosphatase activity
DRG92_RS11795	COG2827	Endonuclease containing a URI domain
DRG92_RS11800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DRG92_RS11810	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DRG92_RS11835	COG1082	Xylose isomerase domain protein TIM barrel
DRG92_RS11845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DRG92_RS11850	COG3263	regulation of cellular component size
DRG92_RS11860	COG0531	amino acid
DRG92_RS11885	COG0531	amino acid
DRG92_RS11895	COG0490	domain, Protein
DRG92_RS11895	COG0471	metal ion transport
DRG92_RS11900	COG0569	domain protein
DRG92_RS11905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DRG92_RS11910	COG0569	domain protein
DRG92_RS11915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DRG92_RS11920	COG4651	solute:proton antiporter activity
DRG92_RS11920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DRG92_RS11930	COG0531	amino acid
DRG92_RS11935	COG0531	amino acid
DRG92_RS11940	COG2202	Pas domain
DRG92_RS11940	COG2205	protein histidine kinase activity
DRG92_RS11945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DRG92_RS11975	COG0517	IMP dehydrogenase activity
DRG92_RS11975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DRG92_RS11995	COG1309	transcriptional regulator
DRG92_RS12000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DRG92_RS12010	COG1061	Type III restriction enzyme res subunit
DRG92_RS12025	COG0745	RESPONSE REGULATOR receiver
DRG92_RS12030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DRG92_RS12035	COG0573	inorganic phosphate transmembrane transporter activity
DRG92_RS12040	COG0581	inorganic phosphate transmembrane transporter activity
DRG92_RS12045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DRG92_RS12050	COG0704	Plays a role in the regulation of phosphate uptake
DRG92_RS12080	COG0307	riboflavin synthase, alpha
DRG92_RS12105	COG0477	Major facilitator Superfamily
DRG92_RS12130	COG0531	amino acid
DRG92_RS12145	COG0210	DNA helicase
DRG92_RS12150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DRG92_RS12155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DRG92_RS12200	COG3275	phosphorelay sensor kinase activity
DRG92_RS12205	COG3279	Response regulator of the LytR AlgR family
DRG92_RS12220	COG0415	Belongs to the DNA photolyase family
DRG92_RS12240	COG0423	glycine-tRNA ligase activity
DRG92_RS12250	COG2003	Belongs to the UPF0758 family
DRG92_RS12255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DRG92_RS12265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DRG92_RS12275	COG0346	lactoylglutathione lyase activity
DRG92_RS12280	COG0123	including yeast histone deacetylase and acetoin utilization protein
DRG92_RS12295	COG0825	malonyl-CoA metabolic process
DRG92_RS12310	COG0484	heat shock protein binding
DRG92_RS12315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DRG92_RS12320	COG1420	regulation of RNA biosynthetic process
DRG92_RS12325	COG0616	signal peptide processing
DRG92_RS12330	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DRG92_RS12335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DRG92_RS12350	COG0071	Belongs to the small heat shock protein (HSP20) family
DRG92_RS12370	COG0626	cystathionine gamma-synthase activity
DRG92_RS12400	COG0109	protoheme IX farnesyltransferase activity
DRG92_RS12410	COG0842	Transport permease protein
DRG92_RS12415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DRG92_RS12420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DRG92_RS12430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DRG92_RS12440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DRG92_RS12460	COG0167	dihydroorotate dehydrogenase activity
DRG92_RS12465	COG0384	phenazine biosynthesis protein PhzF
DRG92_RS12475	COG0768	penicillin binding
DRG92_RS12480	COG0772	Belongs to the SEDS family
DRG92_RS12485	COG0004	ammonium transporteR
DRG92_RS12490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DRG92_RS12495	COG3304	Inner membrane component domain
DRG92_RS12530	COG0784	Response regulator, receiver
DRG92_RS12530	COG2205	protein histidine kinase activity
DRG92_RS12565	COG1840	ABC-type Fe3 transport system, periplasmic component
DRG92_RS12575	COG0438	transferase activity, transferring glycosyl groups
DRG92_RS12580	COG0667	Aldo Keto reductase
DRG92_RS12590	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DRG92_RS12600	COG0463	Glycosyl transferase, family 2
DRG92_RS12605	COG0187	DNA topoisomerase II activity
DRG92_RS12610	COG0366	Alpha amylase catalytic
DRG92_RS12620	COG0517	IMP dehydrogenase activity
DRG92_RS12625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DRG92_RS12650	COG0802	atpase or kinase
DRG92_RS12655	COG0285	dihydrofolate synthase activity
DRG92_RS12660	COG0003	Pfam Anion-transporting ATPase
DRG92_RS12670	COG1215	transferase activity, transferring glycosyl groups
DRG92_RS12680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DRG92_RS12685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DRG92_RS12700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DRG92_RS12705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DRG92_RS12710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DRG92_RS12735	COG0617	tRNA 3'-terminal CCA addition
DRG92_RS12740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DRG92_RS12750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DRG92_RS12760	COG0517	IMP dehydrogenase activity
DRG92_RS12765	COG1028	Short-chain dehydrogenase reductase Sdr
DRG92_RS12805	COG4771	TonB-dependent receptor
DRG92_RS12825	COG0402	S-adenosylhomocysteine deaminase activity
DRG92_RS12830	COG1278	Cold shock
DRG92_RS12840	COG0390	transport system, permease component
DRG92_RS12845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DRG92_RS12855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DRG92_RS12860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DRG92_RS12870	COG0798	PFAM Bile acid sodium symporter
DRG92_RS12875	COG2226	methyltransferase
DRG92_RS12880	COG0640	Transcriptional regulator
DRG92_RS12930	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DRG92_RS12960	COG4555	ABC transporter
DRG92_RS12985	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DRG92_RS12990	COG5002	protein histidine kinase activity
DRG92_RS12995	COG0745	RESPONSE REGULATOR receiver
DRG92_RS13000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DRG92_RS13005	COG1363	Peptidase, m42
DRG92_RS13010	COG0745	RESPONSE REGULATOR receiver
DRG92_RS13015	COG0745	RESPONSE REGULATOR receiver
DRG92_RS13025	COG0482	sulfurtransferase activity
DRG92_RS13030	COG0251	oxidation-reduction process
DRG92_RS13040	COG0860	N-Acetylmuramoyl-L-alanine amidase
DRG92_RS13055	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DRG92_RS13060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DRG92_RS13065	COG1127	ABC transporter
DRG92_RS13075	COG4399	Belongs to the UPF0754 family
DRG92_RS13105	COG3335	DDE superfamily endonuclease
DRG92_RS13110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DRG92_RS13155	COG2205	protein histidine kinase activity
DRG92_RS13185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DRG92_RS13205	COG0842	Transport permease protein
DRG92_RS13205	COG1131	(ABC) transporter
DRG92_RS13205	COG1716	ATPase activity
DRG92_RS13230	COG0363	glucosamine-6-phosphate deaminase activity
DRG92_RS13240	COG0673	inositol 2-dehydrogenase activity
DRG92_RS13250	COG0673	inositol 2-dehydrogenase activity
DRG92_RS13280	COG0442	prolyl-tRNA aminoacylation
DRG92_RS13300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DRG92_RS13315	COG0799	negative regulation of ribosome biogenesis
DRG92_RS13320	COG2363	Small membrane protein
DRG92_RS13345	COG0321	lipoyl(octanoyl) transferase activity
DRG92_RS13360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DRG92_RS13365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DRG92_RS13370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DRG92_RS13380	COG1435	thymidine kinase activity
DRG92_RS13395	COG2095	MarC family integral membrane protein
DRG92_RS13400	COG0583	DNA-binding transcription factor activity
DRG92_RS13460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DRG92_RS13490	COG1191	sigma factor activity
DRG92_RS13510	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DRG92_RS13515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DRG92_RS13520	COG1684	flagellar biosynthetic protein fliR
DRG92_RS13525	COG1987	bacterial-type flagellum assembly
DRG92_RS13530	COG1338	Plays a role in the flagellum-specific transport system
DRG92_RS13540	COG1776	CheC inhibitor of MCP methylation
DRG92_RS13540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DRG92_RS13545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DRG92_RS13555	COG1360	Flagellar Motor Protein
DRG92_RS13560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DRG92_RS13565	COG3290	protein histidine kinase activity
DRG92_RS13565	COG0840	transmembrane signaling receptor activity
DRG92_RS13590	COG0741	lytic transglycosylase activity
DRG92_RS13595	COG2201	protein-glutamate methylesterase activity
DRG92_RS13600	COG0643	Histidine kinase
DRG92_RS13600	COG0784	Response regulator, receiver
DRG92_RS13600	COG2198	Histidine kinase
DRG92_RS13610	COG0745	RESPONSE REGULATOR receiver
DRG92_RS13615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DRG92_RS13620	COG0835	chemotaxis
DRG92_RS13625	COG1749	Flagellar hook protein flgE
DRG92_RS13635	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DRG92_RS13655	COG1157	protein secretion by the type III secretion system
DRG92_RS13665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DRG92_RS13695	COG3852	Histidine kinase
DRG92_RS13700	COG2204	response regulator
DRG92_RS13730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DRG92_RS13740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DRG92_RS13745	COG1256	bacterial-type flagellum assembly
DRG92_RS13745	COG4786	Flagellar basal body rod
DRG92_RS13760	COG1706	bacterial-type flagellum-dependent cell motility
DRG92_RS13775	COG4786	Flagellar basal body rod
DRG92_RS13780	COG4786	Flagellar basal body rod
DRG92_RS13810	COG1446	asparaginase
DRG92_RS13830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DRG92_RS13835	COG3118	belongs to the thioredoxin family
DRG92_RS13845	COG0741	lytic transglycosylase activity
DRG92_RS13845	COG1388	LysM domain
DRG92_RS13850	COG0405	Gamma-glutamyltransferase
DRG92_RS13885	COG0217	transcriptional regulatory protein
DRG92_RS13890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DRG92_RS13905	COG4152	abc transporter atp-binding protein
DRG92_RS13910	COG1668	transmembrane transport
DRG92_RS13915	COG0544	peptidyl-prolyl cis-trans isomerase activity
DRG92_RS13920	COG0740	serine-type endopeptidase activity
DRG92_RS13930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DRG92_RS13940	COG1418	mRNA catabolic process
DRG92_RS13955	COG1028	Short-chain dehydrogenase reductase Sdr
DRG92_RS13960	COG2267	carboxylic ester hydrolase activity
DRG92_RS13965	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DRG92_RS13980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DRG92_RS14015	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DRG92_RS14025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DRG92_RS14055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DRG92_RS14070	COG0668	transmembrane transport
DRG92_RS14075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DRG92_RS14090	COG4232	protein-disulfide reductase activity
DRG92_RS14165	COG3275	phosphorelay sensor kinase activity
DRG92_RS14170	COG3279	Response regulator of the LytR AlgR family
DRG92_RS14175	COG4771	TonB-dependent receptor
DRG92_RS14190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DRG92_RS14195	COG2234	aminopeptidase activity
DRG92_RS14200	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DRG92_RS14205	COG3720	iron ion transport
DRG92_RS14220	COG4206	TonB-dependent receptor
DRG92_RS14245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DRG92_RS14250	COG2050	protein possibly involved in aromatic compounds catabolism
DRG92_RS14255	COG0346	lactoylglutathione lyase activity
DRG92_RS14280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DRG92_RS14290	COG1643	Atp-dependent helicase
DRG92_RS14295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DRG92_RS14320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DRG92_RS14325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DRG92_RS14330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DRG92_RS14365	COG1595	DNA-templated transcription, initiation
DRG92_RS14395	COG0579	oxidoreductase
DRG92_RS14405	COG0121	glutamine amidotransferase
DRG92_RS14445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DRG92_RS14450	COG1757	Na H antiporter
DRG92_RS14455	COG4221	oxidoreductase activity
DRG92_RS14470	COG4221	oxidoreductase activity
DRG92_RS14485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DRG92_RS14500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DRG92_RS14520	COG2197	response regulator
DRG92_RS14525	COG2197	response regulator
DRG92_RS14530	COG5002	protein histidine kinase activity
DRG92_RS14535	COG0237	dephospho-CoA kinase activity
DRG92_RS14540	COG0537	adenosine 5'-monophosphoramidase activity
DRG92_RS14550	COG0302	gtp cyclohydrolase
DRG92_RS14570	COG0456	acetyltransferase
DRG92_RS14580	COG1515	deoxyribonuclease V activity
DRG92_RS14590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DRG92_RS14595	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DRG92_RS14600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DRG92_RS14605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DRG92_RS14610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DRG92_RS14615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DRG92_RS14615	COG0072	phenylalanine-tRNA ligase activity
DRG92_RS14630	COG0488	(ABC) transporter
DRG92_RS14650	COG1228	amidohydrolase
DRG92_RS14665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DRG92_RS14670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DRG92_RS14675	COG0116	Belongs to the methyltransferase superfamily
DRG92_RS14710	COG0347	Belongs to the P(II) protein family
DRG92_RS14725	COG0745	RESPONSE REGULATOR receiver
DRG92_RS14730	COG5002	protein histidine kinase activity
DRG92_RS14740	COG0542	response to heat
DRG92_RS14775	COG1132	(ABC) transporter
DRG92_RS14795	COG4771	TonB-dependent receptor
DRG92_RS14815	COG1472	Belongs to the glycosyl hydrolase 3 family
DRG92_RS14820	COG0477	Major facilitator Superfamily
DRG92_RS14830	COG1136	(ABC) transporter
DRG92_RS14845	COG0577	efflux transmembrane transporter activity
DRG92_RS14870	COG3279	Response regulator of the LytR AlgR family
DRG92_RS14875	COG3275	phosphorelay sensor kinase activity
DRG92_RS14990	COG4206	TonB-dependent receptor
DRG92_RS14990	COG1629	transport
DRG92_RS15030	COG0346	lactoylglutathione lyase activity
DRG92_RS15280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DRG92_RS15295	COG4974	Belongs to the 'phage' integrase family
DRG92_RS15305	COG0666	response to abiotic stimulus
DRG92_RS15320	COG1525	nuclease
DRG92_RS15325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DRG92_RS15365	COG1192	Involved in chromosome partitioning
DRG92_RS15445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair