locus-tag	class	description
CN538_RS00050	COG2885	chlorophyll binding
CN538_RS00050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CN538_RS00130	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CN538_RS00145	COG2301	Belongs to the HpcH HpaI aldolase family
CN538_RS00170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CN538_RS00190	COG0511	ligase activity, forming carbon-carbon bonds
CN538_RS00230	COG0302	gtp cyclohydrolase
CN538_RS00240	COG1040	competence protein
CN538_RS00300	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CN538_RS00305	COG0830	nickel cation binding
CN538_RS00310	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CN538_RS00315	COG0804	urea catabolic process
CN538_RS00320	COG0832	Belongs to the urease beta subunit family
CN538_RS00325	COG0831	urea catabolic process
CN538_RS00385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CN538_RS00400	COG0134	indole-3-glycerol-phosphate synthase activity
CN538_RS00405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CN538_RS00520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CN538_RS00625	COG0297	glycogen (starch) synthase activity
CN538_RS00645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CN538_RS00645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CN538_RS00665	COG1074	ATP-dependent DNA helicase activity
CN538_RS00670	COG1074	ATP-dependent DNA helicase activity
CN538_RS00675	COG1074	ATP-dependent DNA helicase activity
CN538_RS00680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CN538_RS00685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CN538_RS00700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CN538_RS00720	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CN538_RS00730	COG0656	L-ascorbic acid biosynthetic process
CN538_RS00735	COG1515	deoxyribonuclease V activity
CN538_RS00755	COG1940	carbohydrate kinase activity
CN538_RS00765	COG0477	Major facilitator Superfamily
CN538_RS00780	COG0655	NAD(P)H dehydrogenase (quinone) activity
CN538_RS00800	COG1063	alcohol dehydrogenase
CN538_RS00805	COG2721	sulfolactate sulfo-lyase activity
CN538_RS00815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS00830	COG2040	homocysteine
CN538_RS00835	COG0833	amino acid
CN538_RS00845	COG0129	dihydroxy-acid dehydratase activity
CN538_RS00870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CN538_RS00905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN538_RS00910	COG0277	FAD linked oxidase domain protein
CN538_RS00915	COG2084	Dehydrogenase
CN538_RS00935	COG1671	Belongs to the UPF0178 family
CN538_RS00955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CN538_RS01010	COG2818	Glycosylase
CN538_RS01015	COG1063	alcohol dehydrogenase
CN538_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CN538_RS01075	COG2181	nitrate reductase activity
CN538_RS01075	COG0247	lactate metabolic process
CN538_RS01080	COG1902	pentaerythritol trinitrate reductase activity
CN538_RS01080	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN538_RS01100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CN538_RS01135	COG2822	iron ion transport
CN538_RS01160	COG2706	6-phosphogluconolactonase activity
CN538_RS01165	COG2706	6-phosphogluconolactonase activity
CN538_RS01175	COG1966	Carbon starvation protein
CN538_RS01200	COG1522	sequence-specific DNA binding
CN538_RS01215	COG3483	tryptophan 2,3-dioxygenase activity
CN538_RS01225	COG2271	Major facilitator Superfamily
CN538_RS01230	COG1063	alcohol dehydrogenase
CN538_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS01280	COG0582	viral genome integration into host DNA
CN538_RS01370	COG1120	ATPase activity
CN538_RS01390	COG4264	IucA IucC family
CN538_RS01410	COG2814	Major facilitator Superfamily
CN538_RS01415	COG0514	ATP-dependent DNA helicase (RecQ)
CN538_RS01430	COG4615	Cyclic peptide transporter
CN538_RS01460	COG0436	Aminotransferase
CN538_RS01475	COG1984	allophanate hydrolase subunit 2
CN538_RS01485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CN538_RS01540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CN538_RS01545	COG1116	anion transmembrane transporter activity
CN538_RS01550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CN538_RS01555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CN538_RS01560	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CN538_RS01570	COG0583	DNA-binding transcription factor activity
CN538_RS01585	COG0583	DNA-binding transcription factor activity
CN538_RS01625	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CN538_RS01645	COG0730	response to heat
CN538_RS01660	COG0494	nUDIX hydrolase
CN538_RS01675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CN538_RS01680	COG2918	glutathione biosynthetic process
CN538_RS01685	COG2183	response to ionizing radiation
CN538_RS01700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CN538_RS01735	COG4221	oxidoreductase activity
CN538_RS01740	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CN538_RS01770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CN538_RS01780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CN538_RS01780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CN538_RS01785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CN538_RS01790	COG0366	Alpha amylase catalytic
CN538_RS01795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CN538_RS01805	COG3706	GGDEF domain
CN538_RS01810	COG1215	transferase activity, transferring glycosyl groups
CN538_RS01825	COG0800	Aldolase
CN538_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS01865	COG4948	Mandelate Racemase Muconate Lactonizing
CN538_RS01870	COG2188	Transcriptional regulator
CN538_RS01905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CN538_RS01930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CN538_RS01935	COG1012	belongs to the aldehyde dehydrogenase family
CN538_RS01940	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CN538_RS01945	COG4181	ATPase activity
CN538_RS01975	COG1366	Belongs to the anti-sigma-factor antagonist family
CN538_RS01995	COG1560	Kdo2-lipid A biosynthetic process
CN538_RS02000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CN538_RS02025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CN538_RS02030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CN538_RS02040	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CN538_RS02045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CN538_RS02050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CN538_RS02110	COG0084	hydrolase, TatD family'
CN538_RS02115	COG2197	response regulator
CN538_RS02155	COG1741	Belongs to the pirin family
CN538_RS02160	COG0583	DNA-binding transcription factor activity
CN538_RS02170	COG2814	Major facilitator Superfamily
CN538_RS02175	COG0583	DNA-binding transcription factor activity
CN538_RS02180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CN538_RS02200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CN538_RS02225	COG1538	Outer membrane efflux protein
CN538_RS02355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CN538_RS02380	COG1012	belongs to the aldehyde dehydrogenase family
CN538_RS02385	COG1349	DNA-binding transcription factor activity
CN538_RS02390	COG1072	(Pantothenic acid kinase))
CN538_RS02395	COG1609	Transcriptional regulator
CN538_RS02410	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN538_RS02415	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN538_RS02425	COG3248	Nucleoside-binding outer membrane protein
CN538_RS02430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CN538_RS02435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CN538_RS02450	COG0813	purine-nucleoside phosphorylase activity
CN538_RS02455	COG0295	cytidine deaminase activity
CN538_RS02465	COG0484	heat shock protein binding
CN538_RS02475	COG3530	Putative quorum-sensing-regulated virulence factor
CN538_RS02480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CN538_RS02500	COG0668	transmembrane transport
CN538_RS02515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CN538_RS02545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CN538_RS02550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CN538_RS02555	COG0297	glycogen (starch) synthase activity
CN538_RS02595	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CN538_RS02620	COG0837	glucose binding
CN538_RS02630	COG4989	oxidoreductase activity
CN538_RS02640	COG0583	DNA-binding transcription factor activity
CN538_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS02680	COG1737	Transcriptional regulator
CN538_RS02685	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CN538_RS02690	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CN538_RS02705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CN538_RS02715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CN538_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS02770	COG0251	oxidation-reduction process
CN538_RS02775	COG0589	response to stress
CN538_RS02780	COG0659	secondary active sulfate transmembrane transporter activity
CN538_RS02820	COG3246	L-lysine catabolic process to acetate
CN538_RS02865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CN538_RS02875	COG0583	DNA-binding transcription factor activity
CN538_RS02885	COG3591	Belongs to the peptidase S1B family
CN538_RS02885	COG1864	DNA RNA non-specific endonuclease
CN538_RS02890	COG0028	Belongs to the TPP enzyme family
CN538_RS02905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CN538_RS02930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CN538_RS02935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CN538_RS02960	COG2814	Major facilitator Superfamily
CN538_RS02970	COG1522	sequence-specific DNA binding
CN538_RS02980	COG0006	proline dipeptidase activity
CN538_RS02990	COG2271	Major facilitator Superfamily
CN538_RS03040	COG1653	transport
CN538_RS03075	COG1609	Transcriptional regulator
CN538_RS03085	COG2610	gluconate transmembrane transporter activity
CN538_RS03095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CN538_RS03100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CN538_RS03105	COG2967	ApaG domain
CN538_RS03110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CN538_RS03130	COG3178	'Phosphotransferase
CN538_RS03140	COG1765	OsmC-like protein
CN538_RS03150	COG0537	adenosine 5'-monophosphoramidase activity
CN538_RS03170	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN538_RS03185	COG1609	Transcriptional regulator
CN538_RS03190	COG3954	Phosphoribulokinase
CN538_RS03215	COG2951	lytic endotransglycosylase activity
CN538_RS03220	COG0415	Belongs to the DNA photolyase family
CN538_RS03230	COG1006	Multisubunit Na H antiporter MnhC subunit
CN538_RS03235	COG0651	ATP synthesis coupled electron transport
CN538_RS03240	COG1863	multisubunit Na H antiporter MnhE subunit
CN538_RS03245	COG2212	antiporter activity
CN538_RS03250	COG1320	monovalent cation:proton antiporter activity
CN538_RS03270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CN538_RS03280	COG0305	Participates in initiation and elongation during chromosome replication
CN538_RS03300	COG0360	Binds together with S18 to 16S ribosomal RNA
CN538_RS03355	COG1024	Enoyl-CoA hydratase
CN538_RS03365	COG0657	acetylesterase activity
CN538_RS03385	COG2719	SpoVR family
CN538_RS03390	COG2718	Belongs to the UPF0229 family
CN538_RS03405	COG1902	pentaerythritol trinitrate reductase activity
CN538_RS03405	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN538_RS03445	COG0037	tRNA processing
CN538_RS03485	COG0346	lactoylglutathione lyase activity
CN538_RS03495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CN538_RS03500	COG0625	glutathione transferase activity
CN538_RS03515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CN538_RS03525	COG0335	large ribosomal subunit rRNA binding
CN538_RS03530	COG0336	Belongs to the RNA methyltransferase TrmD family
CN538_RS03535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CN538_RS03540	COG0228	four-way junction DNA binding
CN538_RS03585	COG2925	Exonuclease
CN538_RS03590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CN538_RS03595	COG2894	cell division
CN538_RS03600	COG0850	regulation of cytokinetic process
CN538_RS03640	COG3118	belongs to the thioredoxin family
CN538_RS03660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CN538_RS03700	COG3022	response to hydroperoxide
CN538_RS03740	COG2186	Transcriptional regulator
CN538_RS03790	COG1230	cation diffusion facilitator family transporter
CN538_RS03795	COG3276	selenocysteine insertion sequence binding
CN538_RS03805	COG3058	Necessary for formate dehydrogenase activity
CN538_RS03810	COG2864	formate dehydrogenase
CN538_RS03815	COG0437	4 iron, 4 sulfur cluster binding
CN538_RS03825	COG3383	formate dehydrogenase (NAD+) activity
CN538_RS03825	COG0243	molybdopterin cofactor binding
CN538_RS03840	COG2358	TRAP transporter, solute receptor (TAXI family
CN538_RS03855	COG1830	Aldolase
CN538_RS03865	COG1070	Carbohydrate kinase
CN538_RS03900	COG1063	alcohol dehydrogenase
CN538_RS03905	COG0698	ribose 5-phosphate isomerase
CN538_RS03910	COG2376	Dihydroxyacetone kinase
CN538_RS03915	COG0149	triose-phosphate isomerase activity
CN538_RS03920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CN538_RS03965	COG1830	Aldolase
CN538_RS03975	COG1346	cytolysis
CN538_RS03980	COG2267	carboxylic ester hydrolase activity
CN538_RS04025	COG0745	RESPONSE REGULATOR receiver
CN538_RS04030	COG0642	Histidine kinase
CN538_RS04070	COG3485	protocatechuate 3,4-dioxygenase
CN538_RS04080	COG0583	DNA-binding transcription factor activity
CN538_RS04090	COG2031	fatty acid transporter
CN538_RS04100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CN538_RS04115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CN538_RS04165	COG1414	Transcriptional regulator
CN538_RS04175	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CN538_RS04175	COG1082	Xylose isomerase domain protein TIM barrel
CN538_RS04190	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CN538_RS04225	COG1946	Acyl-CoA thioesterase
CN538_RS04235	COG2207	Transcriptional regulator
CN538_RS04275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CN538_RS04280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CN538_RS04290	COG2031	fatty acid transporter
CN538_RS04320	COG1732	Glycine betaine
CN538_RS04330	COG1125	glycine betaine transport
CN538_RS04335	COG1174	glycine betaine transport
CN538_RS04360	COG2851	Citrate transporter
CN538_RS04365	COG0596	Alpha beta hydrolase
CN538_RS04385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CN538_RS04425	COG1929	Belongs to the glycerate kinase type-1 family
CN538_RS04430	COG0783	Belongs to the Dps family
CN538_RS04450	COG0693	protein deglycase activity
CN538_RS04465	COG2195	Cleaves the N-terminal amino acid of tripeptides
CN538_RS04470	COG1444	tRNA N-acetyltransferase activity
CN538_RS04495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CN538_RS04505	COG2080	2 iron, 2 sulfur cluster binding
CN538_RS04510	COG0025	NhaP-type Na H and K H
CN538_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS04540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS04545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN538_RS04560	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CN538_RS04565	COG2080	2 iron, 2 sulfur cluster binding
CN538_RS04575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CN538_RS04650	COG5285	phytanoyl-CoA dioxygenase
CN538_RS04675	COG3772	lysozyme
CN538_RS04810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CN538_RS04920	COG0730	response to heat
CN538_RS04940	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CN538_RS04945	COG1194	a g-specific adenine glycosylase
CN538_RS04970	COG0107	imidazoleglycerol-phosphate synthase activity
CN538_RS05000	COG0709	Synthesizes selenophosphate from selenide and ATP
CN538_RS05005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CN538_RS05015	COG1902	pentaerythritol trinitrate reductase activity
CN538_RS05020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CN538_RS05060	COG1183	phosphatidylcholine synthase activity
CN538_RS05065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CN538_RS05075	COG0440	acetolactate synthase activity
CN538_RS05085	COG2814	Major facilitator Superfamily
CN538_RS05170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CN538_RS05175	COG1047	Peptidyl-prolyl cis-trans
CN538_RS05200	COG0268	Binds directly to 16S ribosomal RNA
CN538_RS05205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CN538_RS05210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CN538_RS05215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CN538_RS05220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CN538_RS05225	COG0142	geranyltranstransferase activity
CN538_RS05265	COG1090	epimerase
CN538_RS05270	COG0789	Transcriptional regulator
CN538_RS05300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CN538_RS05315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CN538_RS05345	COG0629	single-stranded DNA binding
CN538_RS05350	COG2814	Major facilitator Superfamily
CN538_RS05360	COG0203	ribosomal protein L17
CN538_RS05365	COG0202	RNA polymerase activity
CN538_RS05375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CN538_RS05380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CN538_RS05385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CN538_RS05395	COG0200	Binds to the 23S rRNA
CN538_RS05400	COG1841	ribosomal large subunit assembly
CN538_RS05405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CN538_RS05410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CN538_RS05420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CN538_RS05425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CN538_RS05430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CN538_RS05435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CN538_RS05440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CN538_RS05445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CN538_RS05450	COG0255	Belongs to the universal ribosomal protein uL29 family
CN538_RS05455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CN538_RS05460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CN538_RS05465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CN538_RS05470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CN538_RS05475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CN538_RS05480	COG0089	rRNA binding
CN538_RS05490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CN538_RS05495	COG0051	transcription antitermination factor activity, RNA binding
CN538_RS05505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CN538_RS05510	COG0049	tRNA binding
CN538_RS05515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CN538_RS05525	COG0085	RNA polymerase activity
CN538_RS05535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CN538_RS05540	COG0081	regulation of translation
CN538_RS05545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CN538_RS05615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CN538_RS05655	COG1489	DNA binding
CN538_RS05660	COG0436	Aminotransferase
CN538_RS05665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CN538_RS05670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CN538_RS05685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CN538_RS05690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CN538_RS05700	COG1072	(Pantothenic acid kinase))
CN538_RS05715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CN538_RS05720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CN538_RS05725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CN538_RS05740	COG0779	Required for maturation of 30S ribosomal subunits
CN538_RS05775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CN538_RS05780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CN538_RS05805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CN538_RS05815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN538_RS05820	COG1120	ATPase activity
CN538_RS05865	COG0484	heat shock protein binding
CN538_RS05870	COG0443	Heat shock 70 kDa protein
CN538_RS05875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CN538_RS05880	COG0497	DNA recombination
CN538_RS05890	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CN538_RS05920	COG0668	transmembrane transport
CN538_RS05925	COG1940	carbohydrate kinase activity
CN538_RS05950	COG0165	Argininosuccinate lyase
CN538_RS05965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CN538_RS05975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CN538_RS05980	COG1011	Hydrolase
CN538_RS05985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CN538_RS05990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CN538_RS06035	COG1034	ATP synthesis coupled electron transport
CN538_RS06050	COG0649	NAD binding
CN538_RS06050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CN538_RS06060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CN538_RS06070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS06075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN538_RS06080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN538_RS06085	COG1490	D-aminoacyl-tRNA deacylase activity
CN538_RS06095	COG4572	Cation transport regulator
CN538_RS06140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CN538_RS06155	COG1115	amino acid carrier protein
CN538_RS06160	COG2363	Small membrane protein
CN538_RS06180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CN538_RS06185	COG1280	lysine exporter protein (LysE YggA)
CN538_RS06200	COG2960	long-chain fatty acid transporting porin activity
CN538_RS06240	COG0251	oxidation-reduction process
CN538_RS06245	COG1126	abc transporter atp-binding protein
CN538_RS06250	COG0765	amino acid transport
CN538_RS06255	COG4597	amino acid ABC transporter
CN538_RS06260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CN538_RS06275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CN538_RS06285	COG1272	protein, Hemolysin III
CN538_RS06295	COG1132	(ABC) transporter
CN538_RS06310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CN538_RS06315	COG4597	amino acid ABC transporter
CN538_RS06320	COG0765	amino acid transport
CN538_RS06325	COG1126	abc transporter atp-binding protein
CN538_RS06335	COG2076	Multidrug Resistance protein
CN538_RS06340	COG2076	Multidrug Resistance protein
CN538_RS06375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN538_RS06385	COG2203	Gaf domain
CN538_RS06385	COG2200	EAL domain
CN538_RS06385	COG2199	diguanylate cyclase activity
CN538_RS06410	COG4772	TonB-dependent receptor
CN538_RS06425	COG3137	Salt-induced outer membrane protein
CN538_RS06455	COG0765	amino acid transport
CN538_RS06490	COG3938	Belongs to the proline racemase family
CN538_RS06495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CN538_RS06500	COG1879	ABC-type sugar transport system periplasmic component
CN538_RS06510	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN538_RS06515	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN538_RS06530	COG3257	ureidoglycine aminohydrolase activity
CN538_RS06535	COG1288	antiporter activity
CN538_RS06560	COG1953	Uracil, thiamine, allantoin
CN538_RS06570	COG2351	hydroxyisourate hydrolase activity
CN538_RS06575	COG3195	allantoin biosynthetic process
CN538_RS06575	COG3648	Uricase
CN538_RS06585	COG0540	Belongs to the ATCase OTCase family
CN538_RS06590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CN538_RS06605	COG1505	serine-type exopeptidase activity
CN538_RS06645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CN538_RS06650	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CN538_RS06670	COG0793	Belongs to the peptidase S41A family
CN538_RS06675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CN538_RS06715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CN538_RS06730	COG1519	Transferase
CN538_RS06755	COG3642	lipopolysaccharide core region biosynthetic process
CN538_RS06780	COG1181	Belongs to the D-alanine--D-alanine ligase family
CN538_RS06795	COG0438	transferase activity, transferring glycosyl groups
CN538_RS06810	COG0752	glycyl-tRNA synthetase alpha subunit
CN538_RS06815	COG0751	glycine-tRNA ligase activity
CN538_RS06825	COG2982	Protein involved in outer membrane biogenesis
CN538_RS06850	COG0840	transmembrane signaling receptor activity
CN538_RS06865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CN538_RS06875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CN538_RS06890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CN538_RS06895	COG0594	ribonuclease P activity
CN538_RS06905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CN538_RS06925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CN538_RS06955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CN538_RS06960	COG2885	chlorophyll binding
CN538_RS06965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CN538_RS06975	COG2197	response regulator
CN538_RS06990	COG0352	thiamine-phosphate diphosphorylase activity
CN538_RS06995	COG0351	phosphomethylpyrimidine kinase
CN538_RS07000	COG0038	chloride channel
CN538_RS07005	COG0316	Belongs to the HesB IscA family
CN538_RS07010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CN538_RS07015	COG0765	amino acid transport
CN538_RS07025	COG0445	tRNA wobble uridine modification
CN538_RS07030	COG0357	Ribosomal RNA small subunit methyltransferase G
CN538_RS07035	COG1192	Involved in chromosome partitioning
CN538_RS07050	COG0356	it plays a direct role in the translocation of protons across the membrane
CN538_RS07060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CN538_RS07070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CN538_RS07075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CN538_RS07080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CN538_RS07085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CN538_RS07090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CN538_RS07115	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CN538_RS07125	COG0745	RESPONSE REGULATOR receiver
CN538_RS07135	COG1349	DNA-binding transcription factor activity
CN538_RS07140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CN538_RS07150	COG4608	Belongs to the ABC transporter superfamily
CN538_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS07180	COG2084	Dehydrogenase
CN538_RS07185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN538_RS07195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS07200	COG3958	Transketolase
CN538_RS07205	COG3959	Transketolase, thiamine diphosphate binding domain
CN538_RS07225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN538_RS07230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS07235	COG0523	cobalamin synthesis protein
CN538_RS07245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CN538_RS07250	COG1131	(ABC) transporter
CN538_RS07255	COG0803	Belongs to the bacterial solute-binding protein 9 family
CN538_RS07275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CN538_RS07280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CN538_RS07285	COG0745	RESPONSE REGULATOR receiver
CN538_RS07295	COG4221	oxidoreductase activity
CN538_RS07310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CN538_RS07345	COG4589	Belongs to the CDS family
CN538_RS07365	COG1942	4-Oxalocrotonate Tautomerase
CN538_RS07390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CN538_RS07395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CN538_RS07400	COG1960	acyl-CoA dehydrogenase activity
CN538_RS07415	COG1598	PFAM Uncharacterised protein family UPF0150
CN538_RS07420	COG2050	protein possibly involved in aromatic compounds catabolism
CN538_RS07425	COG0318	PFAM AMP-dependent synthetase and ligase
CN538_RS07445	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CN538_RS07465	COG0022	dehydrogenase e1 component
CN538_RS07495	COG1737	Transcriptional regulator
CN538_RS07510	COG0587	DNA-directed DNA polymerase activity
CN538_RS07525	COG0704	Plays a role in the regulation of phosphate uptake
CN538_RS07540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CN538_RS07545	COG2375	cellular response to nickel ion
CN538_RS07580	COG0531	amino acid
CN538_RS07585	COG0174	glutamine synthetase
CN538_RS07600	COG3161	chorismate lyase activity
CN538_RS07625	COG1741	Belongs to the pirin family
CN538_RS07630	COG0159	tryptophan synthase activity
CN538_RS07635	COG0133	tryptophan synthase activity
CN538_RS07660	COG1349	DNA-binding transcription factor activity
CN538_RS07665	COG3395	kinase activity
CN538_RS07670	COG0235	Class ii aldolase
CN538_RS07680	COG1522	sequence-specific DNA binding
CN538_RS07695	COG0583	DNA-binding transcription factor activity
CN538_RS07715	COG3639	organic phosphonate transmembrane transporter activity
CN538_RS07720	COG2188	Transcriptional regulator
CN538_RS07725	COG3624	Phosphonate C-P lyase system protein PhnG
CN538_RS07730	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CN538_RS07735	COG3626	phosphonate metabolism
CN538_RS07740	COG3627	carbon phosphorus lyase activity
CN538_RS07755	COG3454	Phosphonate metabolism
CN538_RS07760	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CN538_RS07765	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CN538_RS07770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CN538_RS07785	COG4977	sequence-specific DNA binding
CN538_RS07800	COG1758	RNA polymerase activity
CN538_RS07805	COG0194	GDP metabolic process
CN538_RS07835	COG0418	dihydroorotase activity
CN538_RS07850	COG0406	alpha-ribazole phosphatase activity
CN538_RS07860	COG1522	sequence-specific DNA binding
CN538_RS07865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CN538_RS07870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CN538_RS07875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CN538_RS07885	COG1238	metal cluster binding
CN538_RS07905	COG2199	diguanylate cyclase activity
CN538_RS07925	COG0583	DNA-binding transcription factor activity
CN538_RS07945	COG3069	C4-dicarboxylate transmembrane transporter activity
CN538_RS07950	COG1764	response to oxidative stress
CN538_RS07955	COG1846	Transcriptional regulator
CN538_RS07960	COG0583	DNA-binding transcription factor activity
CN538_RS07985	COG2807	transmembrane transport
CN538_RS08040	COG1454	alcohol dehydrogenase
CN538_RS08055	COG1012	belongs to the aldehyde dehydrogenase family
CN538_RS08060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CN538_RS08070	COG2207	Transcriptional regulator
CN538_RS08080	COG2814	Major facilitator Superfamily
CN538_RS08115	COG2986	histidine ammonia-lyase
CN538_RS08120	COG1757	Na H antiporter
CN538_RS08130	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CN538_RS08130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CN538_RS08135	COG1027	Aspartate ammonia-lyase
CN538_RS08140	COG0494	nUDIX hydrolase
CN538_RS08170	COG0745	RESPONSE REGULATOR receiver
CN538_RS08175	COG0642	Histidine kinase
CN538_RS08180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CN538_RS08225	COG4790	Type iii secretion
CN538_RS08230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CN538_RS08285	COG4964	Belongs to the GSP D family
CN538_RS08290	COG4789	Type iii secretion
CN538_RS08315	COG1561	YicC-like family, N-terminal region
CN538_RS08320	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CN538_RS08345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CN538_RS08350	COG0454	-acetyltransferase
CN538_RS08355	COG0210	DNA helicase
CN538_RS08375	COG0583	DNA-binding transcription factor activity
CN538_RS08455	COG1794	racemase activity, acting on amino acids and derivatives
CN538_RS08490	COG3622	Belongs to the hyi family
CN538_RS08495	COG2084	Dehydrogenase
CN538_RS08500	COG2186	Transcriptional regulator
CN538_RS08505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CN538_RS08510	COG2610	gluconate transmembrane transporter activity
CN538_RS08525	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS08535	COG3706	GGDEF domain
CN538_RS08605	COG2188	Transcriptional regulator
CN538_RS08635	COG0277	FAD linked oxidase domain protein
CN538_RS08640	COG1115	amino acid carrier protein
CN538_RS08655	COG0517	IMP dehydrogenase activity
CN538_RS08660	COG2423	ornithine cyclodeaminase activity
CN538_RS08675	COG1944	ATP diphosphatase activity
CN538_RS08695	COG1120	ATPase activity
CN538_RS08700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN538_RS08720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CN538_RS08725	COG0444	Belongs to the ABC transporter superfamily
CN538_RS08735	COG3842	ATPase activity
CN538_RS08740	COG0395	ABC-type sugar transport system, permease component
CN538_RS08760	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CN538_RS08765	COG2188	Transcriptional regulator
CN538_RS08820	COG3119	arylsulfatase activity
CN538_RS08850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN538_RS08865	COG0583	DNA-binding transcription factor activity
CN538_RS08875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CN538_RS08885	COG1780	Probably involved in ribonucleotide reductase function
CN538_RS08890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CN538_RS08910	COG1051	belongs to the nudix hydrolase family
CN538_RS08915	COG0840	transmembrane signaling receptor activity
CN538_RS09070	COG1253	flavin adenine dinucleotide binding
CN538_RS09090	COG1902	pentaerythritol trinitrate reductase activity
CN538_RS09105	COG1012	belongs to the aldehyde dehydrogenase family
CN538_RS09110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN538_RS09135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CN538_RS09145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN538_RS09155	COG1522	sequence-specific DNA binding
CN538_RS09170	COG1469	GTP cyclohydrolase I activity
CN538_RS09175	COG0667	Aldo Keto reductase
CN538_RS09180	COG0583	DNA-binding transcription factor activity
CN538_RS09185	COG1276	copper resistance
CN538_RS09205	COG0583	DNA-binding transcription factor activity
CN538_RS09210	COG1228	amidohydrolase
CN538_RS09215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CN538_RS09220	COG0671	phosphoesterase, PA-phosphatase related
CN538_RS09225	COG0860	N-Acetylmuramoyl-L-alanine amidase
CN538_RS09240	COG0583	DNA-binding transcription factor activity
CN538_RS09260	COG1024	Enoyl-CoA hydratase
CN538_RS09260	COG1250	3-hydroxyacyl-CoA dehydrogenase
CN538_RS09270	COG1250	3-hydroxyacyl-CoA dehydrogenase
CN538_RS09275	COG1024	Enoyl-CoA hydratase
CN538_RS09285	COG1024	Enoyl-CoA hydratase
CN538_RS09295	COG2079	MmgE PrpD family protein
CN538_RS09305	COG0450	alkyl hydroperoxide reductase
CN538_RS09310	COG0667	Aldo Keto reductase
CN538_RS09315	COG2207	Transcriptional regulator
CN538_RS09320	COG0791	NLP P60 protein
CN538_RS09320	COG0741	lytic transglycosylase activity
CN538_RS09330	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CN538_RS09335	COG2056	Na+-H+ antiporter family
CN538_RS09345	COG1363	Peptidase, m42
CN538_RS09350	COG1566	PFAM secretion protein HlyD family protein
CN538_RS09360	COG1289	transmembrane transporter activity
CN538_RS09370	COG3047	cAMP biosynthetic process
CN538_RS09380	COG0803	Belongs to the bacterial solute-binding protein 9 family
CN538_RS09385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CN538_RS09415	COG0628	permease
CN538_RS09425	COG2200	EAL domain
CN538_RS09495	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN538_RS09525	COG0840	transmembrane signaling receptor activity
CN538_RS09545	COG3852	Histidine kinase
CN538_RS09550	COG2204	response regulator
CN538_RS09555	COG0366	Alpha amylase catalytic
CN538_RS09560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CN538_RS09565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CN538_RS09580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CN538_RS09610	COG0583	DNA-binding transcription factor activity
CN538_RS09615	COG2828	Protein conserved in bacteria
CN538_RS09630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CN538_RS09640	COG0189	ligase activity
CN538_RS09670	COG3706	GGDEF domain
CN538_RS09675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CN538_RS09680	COG0667	Aldo Keto reductase
CN538_RS09690	COG0023	Translation Initiation Factor
CN538_RS09705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN538_RS09755	COG1061	Type III restriction enzyme res subunit
CN538_RS09765	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CN538_RS09770	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CN538_RS09775	COG0535	radical SAM domain protein
CN538_RS09785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CN538_RS09790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CN538_RS09825	COG0425	Belongs to the sulfur carrier protein TusA family
CN538_RS09835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CN538_RS09850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CN538_RS09855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CN538_RS09865	COG1720	tRNA m6t6A37 methyltransferase activity
CN538_RS09870	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CN538_RS09890	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS09910	COG1012	belongs to the aldehyde dehydrogenase family
CN538_RS09915	COG3724	N-succinylarginine dihydrolase activity
CN538_RS09930	COG2807	transmembrane transport
CN538_RS09935	COG2353	YceI-like domain
CN538_RS09970	COG4336	lyase activity
CN538_RS10015	COG0519	Catalyzes the synthesis of GMP from XMP
CN538_RS10050	COG2988	succinylglutamate desuccinylase activity
CN538_RS10080	COG5001	Diguanylate cyclase
CN538_RS10080	COG5002	protein histidine kinase activity
CN538_RS10090	COG0473	3-isopropylmalate dehydrogenase activity
CN538_RS10120	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CN538_RS10135	COG2267	carboxylic ester hydrolase activity
CN538_RS10140	COG0583	DNA-binding transcription factor activity
CN538_RS10150	COG1733	regulation of RNA biosynthetic process
CN538_RS10175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CN538_RS10185	COG3153	acetyltransferase
CN538_RS10185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CN538_RS10230	COG1802	Transcriptional regulator
CN538_RS10240	COG1757	Na H antiporter
CN538_RS10260	COG1414	Transcriptional regulator
CN538_RS10290	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CN538_RS10300	COG0277	FAD linked oxidase domain protein
CN538_RS10305	COG0277	FAD linked oxidase domain protein
CN538_RS10325	COG0625	glutathione transferase activity
CN538_RS10330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN538_RS10410	COG0697	spore germination
CN538_RS10420	COG2358	TRAP transporter, solute receptor (TAXI family
CN538_RS10440	COG0288	reversible hydration of carbon dioxide
CN538_RS10455	COG1609	Transcriptional regulator
CN538_RS10480	COG1609	Transcriptional regulator
CN538_RS10490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CN538_RS10495	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN538_RS10500	COG1129	ABC transporter
CN538_RS10510	COG0745	RESPONSE REGULATOR receiver
CN538_RS10515	COG2205	protein histidine kinase activity
CN538_RS10520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CN538_RS10525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CN538_RS10530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CN538_RS10535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CN538_RS10540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CN538_RS10570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CN538_RS10585	COG4166	transmembrane transport
CN538_RS10595	COG0791	NLP P60 protein
CN538_RS10610	COG3047	cAMP biosynthetic process
CN538_RS10645	COG0271	Belongs to the BolA IbaG family
CN538_RS10665	COG0742	ribosomal rna small subunit methyltransferase
CN538_RS10670	COG0552	protein localization to endoplasmic reticulum
CN538_RS10675	COG2884	Cell division ATP-binding protein ftsE
CN538_RS10680	COG2177	Part of the ABC transporter FtsEX involved in
CN538_RS10690	COG1309	transcriptional regulator
CN538_RS10715	COG0756	dUTP diphosphatase activity
CN538_RS10740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN538_RS10745	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN538_RS10750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS10760	COG4948	Mandelate Racemase Muconate Lactonizing
CN538_RS10775	COG2003	Belongs to the UPF0758 family
CN538_RS10780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CN538_RS10785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CN538_RS10790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CN538_RS10795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CN538_RS10800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CN538_RS10815	COG0686	Belongs to the AlaDH PNT family
CN538_RS10825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN538_RS10830	COG1757	Na H antiporter
CN538_RS10835	COG0180	Tryptophanyl-tRNA synthetase
CN538_RS10840	COG2391	methyltransferase activity
CN538_RS10850	COG2314	TM2 domain
CN538_RS10870	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN538_RS10875	COG1129	ABC transporter
CN538_RS10880	COG1879	ABC-type sugar transport system periplasmic component
CN538_RS10890	COG2197	response regulator
CN538_RS10905	COG0450	alkyl hydroperoxide reductase
CN538_RS10910	COG0492	ferredoxin-NADP+ reductase activity
CN538_RS10915	COG2900	Belongs to the SlyX family
CN538_RS10935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CN538_RS10965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CN538_RS10970	COG0528	UMP kinase activity
CN538_RS10975	COG0233	cytoplasmic translational termination
CN538_RS11010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CN538_RS11030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CN538_RS11040	COG0825	malonyl-CoA metabolic process
CN538_RS11045	COG0037	tRNA processing
CN538_RS11055	COG0037	tRNA processing
CN538_RS11065	COG3118	belongs to the thioredoxin family
CN538_RS11100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CN538_RS11140	COG2165	general secretion pathway protein
CN538_RS11190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CN538_RS11195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CN538_RS11200	COG0140	phosphoribosyl-ATP diphosphatase activity
CN538_RS11215	COG2226	methyltransferase
CN538_RS11230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CN538_RS11250	COG0254	rRNA binding
CN538_RS11300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CN538_RS11305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CN538_RS11310	COG0067	glutamate synthase
CN538_RS11310	COG0070	glutamate synthase
CN538_RS11310	COG0069	glutamate synthase activity
CN538_RS11315	COG0493	'glutamate synthase
CN538_RS11330	COG2233	PERMEase
CN538_RS11335	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CN538_RS11340	COG0504	CTP synthase activity
CN538_RS11345	COG0148	phosphopyruvate hydratase activity
CN538_RS11350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CN538_RS11365	COG1546	Belongs to the CinA family
CN538_RS11375	COG2137	regulation of response to DNA damage stimulus
CN538_RS11390	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CN538_RS11430	COG2059	Chromate
CN538_RS11435	COG2059	Chromate
CN538_RS11450	COG1739	Uncharacterized protein family UPF0029
CN538_RS11455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CN538_RS11465	COG3115	cell septum assembly
CN538_RS11465	COG3115	cell septum assembly
CN538_RS11490	COG4565	transcriptional regulatory protein
CN538_RS11500	COG2350	Protein conserved in bacteria
CN538_RS11505	COG2917	probably involved in intracellular septation
CN538_RS11510	COG0613	PHP domain protein
CN538_RS11515	COG0009	L-threonylcarbamoyladenylate synthase
CN538_RS11530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CN538_RS11545	COG5001	Diguanylate cyclase
CN538_RS11550	COG3025	triphosphatase activity
CN538_RS11555	COG1392	Phosphate transport regulator
CN538_RS11580	COG2205	protein histidine kinase activity
CN538_RS11590	COG2204	response regulator
CN538_RS11595	COG0583	DNA-binding transcription factor activity
CN538_RS11600	COG2249	NAD(P)H dehydrogenase (quinone) activity
CN538_RS11605	COG1570	exodeoxyribonuclease VII activity
CN538_RS11615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CN538_RS11615	COG0519	Catalyzes the synthesis of GMP from XMP
CN538_RS11680	COG0583	DNA-binding transcription factor activity
CN538_RS11690	COG4221	oxidoreductase activity
CN538_RS11750	COG0583	DNA-binding transcription factor activity
CN538_RS11775	COG3706	GGDEF domain
CN538_RS11780	COG2207	Transcriptional regulator
CN538_RS11785	COG1012	belongs to the aldehyde dehydrogenase family
CN538_RS11790	COG1304	FMN binding
CN538_RS11805	COG0583	DNA-binding transcription factor activity
CN538_RS11810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS11825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN538_RS11825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN538_RS11845	COG0697	spore germination
CN538_RS11855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN538_RS11865	COG0765	amino acid transport
CN538_RS11875	COG0500	methyltransferase
CN538_RS11895	COG1609	Transcriptional regulator
CN538_RS11930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CN538_RS11940	COG1473	amidohydrolase
CN538_RS11950	COG0583	DNA-binding transcription factor activity
CN538_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS12015	COG1301	dicarboxylic acid transport
CN538_RS12035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CN538_RS12065	COG0840	transmembrane signaling receptor activity
CN538_RS12115	COG0604	alcohol dehydrogenase
CN538_RS12125	COG3264	Mechanosensitive ion channel
CN538_RS12125	COG1196	nuclear chromosome segregation
CN538_RS12150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CN538_RS12190	COG2721	sulfolactate sulfo-lyase activity
CN538_RS12195	COG2721	sulfolactate sulfo-lyase activity
CN538_RS12200	COG1609	Transcriptional regulator
CN538_RS12215	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN538_RS12215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN538_RS12220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN538_RS12220	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN538_RS12225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CN538_RS12230	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS12235	COG1063	alcohol dehydrogenase
CN538_RS12240	COG2188	Transcriptional regulator
CN538_RS12270	COG1704	LemA family
CN538_RS12275	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CN538_RS12300	COG0653	protein targeting
CN538_RS12320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CN538_RS12325	COG0444	Belongs to the ABC transporter superfamily
CN538_RS12330	COG4608	Belongs to the ABC transporter superfamily
CN538_RS12370	COG1846	Transcriptional regulator
CN538_RS12395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CN538_RS12400	COG2814	Major facilitator Superfamily
CN538_RS12435	COG1054	Belongs to the UPF0176 family
CN538_RS12470	COG0668	transmembrane transport
CN538_RS12475	COG3012	SEC-C Motif Domain Protein
CN538_RS12485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CN538_RS12495	COG2824	Alkylphosphonate utilization operon protein PhnA
CN538_RS12520	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CN538_RS12540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CN538_RS12550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CN538_RS12550	COG1648	precorrin-2 dehydrogenase activity
CN538_RS12560	COG3707	response regulator
CN538_RS12605	COG1175	transmembrane transport
CN538_RS12615	COG3842	ATPase activity
CN538_RS12630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CN538_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS12665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN538_RS12675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CN538_RS12680	COG3181	Tripartite tricarboxylate transporter family receptor
CN538_RS12765	COG2200	EAL domain
CN538_RS12800	COG0745	RESPONSE REGULATOR receiver
CN538_RS12840	COG0346	lactoylglutathione lyase activity
CN538_RS12845	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CN538_RS12860	COG3706	GGDEF domain
CN538_RS12865	COG0671	phosphoesterase, PA-phosphatase related
CN538_RS12880	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS12890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CN538_RS12900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CN538_RS12905	COG0795	lipopolysaccharide-transporting ATPase activity
CN538_RS12910	COG0795	lipopolysaccharide-transporting ATPase activity
CN538_RS12940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CN538_RS12945	COG0564	pseudouridine synthase activity
CN538_RS12950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CN538_RS12960	COG0625	glutathione transferase activity
CN538_RS12965	COG3148	PFAM DTW domain containing protein
CN538_RS12980	COG1280	lysine exporter protein (LysE YggA)
CN538_RS13040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CN538_RS13055	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CN538_RS13060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CN538_RS13065	COG0569	domain protein
CN538_RS13070	COG3360	Dodecin
CN538_RS13085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CN538_RS13090	COG0242	peptide deformylase activity
CN538_RS13100	COG0758	DNA mediated transformation
CN538_RS13105	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CN538_RS13110	COG0009	L-threonylcarbamoyladenylate synthase
CN538_RS13115	COG0408	coproporphyrinogen oxidase activity
CN538_RS13120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CN538_RS13145	COG5002	protein histidine kinase activity
CN538_RS13150	COG0745	RESPONSE REGULATOR receiver
CN538_RS13175	COG0124	histidyl-tRNA synthetase
CN538_RS13180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CN538_RS13185	COG1426	Protein conserved in bacteria
CN538_RS13200	COG0105	UTP biosynthetic process
CN538_RS13235	COG1012	belongs to the aldehyde dehydrogenase family
CN538_RS13255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CN538_RS13285	COG1862	Preprotein translocase
CN538_RS13290	COG0343	queuine tRNA-ribosyltransferase activity
CN538_RS13410	COG1960	acyl-CoA dehydrogenase activity
CN538_RS13425	COG3706	GGDEF domain
CN538_RS13440	COG0386	Belongs to the glutathione peroxidase family
CN538_RS13475	COG0563	adenylate kinase activity
CN538_RS13485	COG1968	undecaprenyl-diphosphatase activity
CN538_RS13490	COG0742	ribosomal rna small subunit methyltransferase
CN538_RS13500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CN538_RS13505	COG0431	NADPH-dependent FMN reductase
CN538_RS13525	COG1748	Saccharopine dehydrogenase
CN538_RS13555	COG1278	Cold shock
CN538_RS13570	COG2070	2-Nitropropane dioxygenase
CN538_RS13580	COG1959	2 iron, 2 sulfur cluster binding
CN538_RS13605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CN538_RS13615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CN538_RS13620	COG2813	Specifically methylates the guanine in position
CN538_RS13625	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CN538_RS13695	COG0494	nUDIX hydrolase
CN538_RS13700	COG3151	Protein conserved in bacteria
CN538_RS13705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CN538_RS13710	COG0175	sulfate reduction
CN538_RS13715	COG2895	sulfate adenylyltransferase (ATP) activity
CN538_RS13720	COG1045	serine acetyltransferase
CN538_RS13730	COG0500	methyltransferase
CN538_RS13760	COG0560	Phosphoserine phosphatase
CN538_RS13760	COG3830	Belongs to the UPF0237 family
CN538_RS13805	COG1509	lysine 2,3-aminomutase activity
CN538_RS13810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CN538_RS13845	COG1309	transcriptional regulator
CN538_RS13850	COG0688	phosphatidylethanolamine metabolic process
CN538_RS13860	COG2252	PERMEase
CN538_RS13865	COG1162	GTPase activity
CN538_RS13880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CN538_RS13880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CN538_RS13885	COG0802	atpase or kinase
CN538_RS13920	COG0330	HflC and HflK could
CN538_RS13930	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CN538_RS13935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CN538_RS13945	COG0719	Fe-S assembly protein
CN538_RS13950	COG0396	ATPase activity
CN538_RS13970	COG2949	membrane
CN538_RS13995	COG3098	single-species biofilm formation
CN538_RS14000	COG3047	cAMP biosynthetic process
CN538_RS14005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CN538_RS14040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CN538_RS14065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CN538_RS14070	COG1053	succinate dehydrogenase
CN538_RS14125	COG0702	epimerase
CN538_RS14130	COG2188	Transcriptional regulator
CN538_RS14145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CN538_RS14145	COG1263	PTS System
CN538_RS14145	COG2190	(PTS) system
CN538_RS14155	COG2190	(PTS) system
CN538_RS14155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CN538_RS14155	COG1263	PTS System
CN538_RS14160	COG0561	phosphatase activity
CN538_RS14165	COG3768	UPF0283 membrane protein
CN538_RS14175	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CN538_RS14185	COG2943	transferase activity, transferring hexosyl groups
CN538_RS14205	COG0791	NLP P60 protein
CN538_RS14230	COG2850	peptidyl-arginine hydroxylation
CN538_RS14240	COG2915	High frequency lysogenization protein hflD homolog
CN538_RS14245	COG0482	sulfurtransferase activity
CN538_RS14255	COG1187	pseudouridine synthase activity
CN538_RS14275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CN538_RS14280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CN538_RS14320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CN538_RS14325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CN538_RS14335	COG0583	DNA-binding transcription factor activity
CN538_RS14340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CN538_RS14345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CN538_RS14350	COG2902	Dehydrogenase
CN538_RS14360	COG0167	dihydroorotate dehydrogenase activity
CN538_RS14365	COG3130	regulation of translation
CN538_RS14370	COG0116	Belongs to the methyltransferase superfamily
CN538_RS14370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CN538_RS14380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN538_RS14400	COG1595	DNA-templated transcription, initiation
CN538_RS14410	COG0501	Belongs to the peptidase M48B family
CN538_RS14420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CN538_RS14430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CN538_RS14465	COG1131	(ABC) transporter
CN538_RS14470	COG0842	Transport permease protein
CN538_RS14475	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CN538_RS14475	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CN538_RS14480	COG0778	Nitroreductase
CN538_RS14495	COG2814	Major facilitator Superfamily
CN538_RS14565	COG2329	Antibiotic biosynthesis monooxygenase
CN538_RS14585	COG1012	belongs to the aldehyde dehydrogenase family
CN538_RS14595	COG1473	amidohydrolase
CN538_RS14605	COG4993	Dehydrogenase
CN538_RS14625	COG0705	Rhomboid family
CN538_RS14640	COG0189	ligase activity
CN538_RS14645	COG0456	acetyltransferase
CN538_RS14650	COG1666	GTP binding
CN538_RS14665	COG2832	Protein of unknown function (DUF454)
CN538_RS14685	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CN538_RS14710	COG3181	Tripartite tricarboxylate transporter family receptor
CN538_RS14740	COG2116	formate transmembrane transporter activity
CN538_RS14745	COG1285	pathogenesis
CN538_RS14760	COG0590	tRNA wobble adenosine to inosine editing
CN538_RS14765	COG1278	Cold shock
CN538_RS14785	COG3339	Conserved Protein
CN538_RS14795	COG2992	FlgJ-related protein
CN538_RS14800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CN538_RS14860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS14880	COG2186	Transcriptional regulator
CN538_RS14895	COG0596	Alpha beta hydrolase
CN538_RS14905	COG2840	Smr protein MutS2
CN538_RS14945	COG0473	3-isopropylmalate dehydrogenase activity
CN538_RS14970	COG0135	phosphoribosylanthranilate isomerase activity
CN538_RS14980	COG0159	tryptophan synthase activity
CN538_RS15025	COG1252	NADH dehydrogenase
CN538_RS15030	COG0656	L-ascorbic acid biosynthetic process
CN538_RS15045	COG0667	Aldo Keto reductase
CN538_RS15080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CN538_RS15085	COG0011	TIGRFAM Protein of
CN538_RS15110	COG0569	domain protein
CN538_RS15170	COG0463	Glycosyl transferase, family 2
CN538_RS15185	COG1360	Flagellar Motor Protein
CN538_RS15205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CN538_RS15210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN538_RS15215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN538_RS15245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CN538_RS15270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CN538_RS15280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CN538_RS15290	COG1309	transcriptional regulator
CN538_RS15305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CN538_RS15310	COG1802	Transcriptional regulator
CN538_RS15335	COG0586	Pfam SNARE associated Golgi protein
CN538_RS15365	COG0604	alcohol dehydrogenase
CN538_RS15370	COG1309	transcriptional regulator
CN538_RS15375	COG0076	glutamate decarboxylase activity
CN538_RS15380	COG2985	domain, Protein
CN538_RS15385	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CN538_RS15390	COG0697	spore germination
CN538_RS15410	COG0156	8-amino-7-oxononanoate synthase activity
CN538_RS15485	COG1086	Polysaccharide biosynthesis protein
CN538_RS15490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CN538_RS15500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CN538_RS15515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CN538_RS15515	COG0517	IMP dehydrogenase activity
CN538_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS15565	COG3321	synthase
CN538_RS15565	COG0604	alcohol dehydrogenase
CN538_RS15595	COG0175	sulfate reduction
CN538_RS15630	COG1088	dTDP-glucose 4,6-dehydratase activity
CN538_RS15640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CN538_RS15680	COG1216	Glycosyl transferase, family 2
CN538_RS15680	COG0438	transferase activity, transferring glycosyl groups
CN538_RS15710	COG1362	aminopeptidase activity
CN538_RS15715	COG4948	Mandelate Racemase Muconate Lactonizing
CN538_RS15725	COG0012	GTP binding
CN538_RS15730	COG0193	aminoacyl-tRNA hydrolase activity
CN538_RS15750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CN538_RS15755	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CN538_RS15770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CN538_RS15815	COG1129	ABC transporter
CN538_RS15825	COG2610	gluconate transmembrane transporter activity
CN538_RS15835	COG0432	Pfam Uncharacterised protein family UPF0047
CN538_RS15845	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CN538_RS15865	COG1349	DNA-binding transcription factor activity
CN538_RS15880	COG3842	ATPase activity
CN538_RS15885	COG3842	ATPase activity
CN538_RS15895	COG0395	ABC-type sugar transport system, permease component
CN538_RS15920	COG1956	GAF domain-containing protein
CN538_RS15925	COG1464	Belongs to the NlpA lipoprotein family
CN538_RS15930	COG2011	ABC-type metal ion transport system permease component
CN538_RS15935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CN538_RS15945	COG0307	riboflavin synthase, alpha
CN538_RS15950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CN538_RS15955	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CN538_RS15975	COG1763	Mo-molybdopterin cofactor biosynthetic process
CN538_RS15980	COG0315	cyclic pyranopterin monophosphate synthase activity
CN538_RS16020	COG1309	transcriptional regulator
CN538_RS16035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CN538_RS16045	COG0584	glycerophosphoryl diester phosphodiesterase
CN538_RS16085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CN538_RS16090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CN538_RS16095	COG0215	cysteine-tRNA ligase activity
CN538_RS16100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CN538_RS16105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CN538_RS16130	COG0544	peptidyl-prolyl cis-trans isomerase activity
CN538_RS16135	COG0740	serine-type endopeptidase activity
CN538_RS16140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CN538_RS16145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CN538_RS16155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CN538_RS16160	COG2130	NADP-dependent
CN538_RS16175	COG0602	queuosine metabolic process
CN538_RS16180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CN538_RS16250	COG0835	chemotaxis
CN538_RS16255	COG0840	transmembrane signaling receptor activity
CN538_RS16265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CN538_RS16275	COG0745	RESPONSE REGULATOR receiver
CN538_RS16315	COG2995	paraquat-inducible protein a
CN538_RS16340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CN538_RS16350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CN538_RS16355	COG1802	Transcriptional regulator
CN538_RS16375	COG1334	flagellar protein FlaG
CN538_RS16405	COG0673	inositol 2-dehydrogenase activity
CN538_RS16440	COG2747	anti-sigma28 factor FlgM
CN538_RS16450	COG1815	bacterial-type flagellum-dependent cell motility
CN538_RS16455	COG1558	bacterial-type flagellum-dependent cell motility
CN538_RS16460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CN538_RS16465	COG1749	Flagellar hook protein flgE
CN538_RS16480	COG1706	bacterial-type flagellum-dependent cell motility
CN538_RS16515	COG3190	flagellar
CN538_RS16520	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CN538_RS16530	COG1580	Controls the rotational direction of flagella during chemotaxis
CN538_RS16555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CN538_RS16560	COG1766	The M ring may be actively involved in energy transduction
CN538_RS16565	COG1677	Flagellar hook-basal body complex protein FliE
CN538_RS16575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CN538_RS16580	COG0598	Magnesium transport protein CorA
CN538_RS16585	COG1187	pseudouridine synthase activity
CN538_RS16590	COG4172	Belongs to the ABC transporter superfamily
CN538_RS16595	COG4239	(ABC) transporter, permease
CN538_RS16600	COG4174	ABC transporter (Permease)
CN538_RS16610	COG3409	Peptidoglycan-binding domain 1 protein
CN538_RS16610	COG5632	N-Acetylmuramoyl-L-alanine amidase
CN538_RS16610	COG1388	LysM domain
CN538_RS16615	COG1388	LysM domain
CN538_RS16615	COG0741	lytic transglycosylase activity
CN538_RS16620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CN538_RS16625	COG2226	methyltransferase
CN538_RS16635	COG0328	RNA-DNA hybrid ribonuclease activity
CN538_RS16660	COG0640	Transcriptional regulator
CN538_RS16690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CN538_RS16765	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CN538_RS16785	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CN538_RS16790	COG0303	'Molybdopterin
CN538_RS16795	COG0521	Mo-molybdopterin cofactor biosynthetic process
CN538_RS16815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CN538_RS16815	COG1042	CoA-binding domain protein
CN538_RS16815	COG0045	succinate-CoA ligase (ADP-forming) activity
CN538_RS16820	COG0517	IMP dehydrogenase activity
CN538_RS16820	COG4175	Glycine betaine
CN538_RS16865	COG2840	Smr protein MutS2
CN538_RS16875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CN538_RS16885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CN538_RS16885	COG0316	Belongs to the HesB IscA family
CN538_RS16900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CN538_RS16905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CN538_RS16910	COG0735	belongs to the Fur family
CN538_RS16915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CN538_RS16920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CN538_RS16925	COG1845	cytochrome c oxidase, subunit III
CN538_RS16935	COG0109	protoheme IX farnesyltransferase activity
CN538_RS16940	COG1917	Cupin 2, conserved barrel domain protein
CN538_RS16945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CN538_RS16950	COG0456	acetyltransferase
CN538_RS16960	COG0288	reversible hydration of carbon dioxide
CN538_RS16970	COG0601	transmembrane transport
CN538_RS16985	COG4608	Belongs to the ABC transporter superfamily
CN538_RS16990	COG0583	DNA-binding transcription factor activity
CN538_RS17000	COG0429	hydrolase of the alpha beta-hydrolase fold
CN538_RS17005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CN538_RS17010	COG2911	Protein conserved in bacteria
CN538_RS17015	COG2911	Protein conserved in bacteria
CN538_RS17030	COG2911	Protein conserved in bacteria
CN538_RS17035	COG0729	surface antigen
CN538_RS17070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CN538_RS17075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN538_RS17080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN538_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS17105	COG1063	alcohol dehydrogenase
CN538_RS17110	COG1028	Short-chain dehydrogenase reductase Sdr
CN538_RS17120	COG2885	chlorophyll binding
CN538_RS17125	COG0823	Involved in the tonB-independent uptake of proteins
CN538_RS17145	COG0824	Thioesterase
CN538_RS17150	COG2255	four-way junction helicase activity
CN538_RS17155	COG0632	four-way junction helicase activity
CN538_RS17205	COG3153	acetyltransferase
CN538_RS17205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CN538_RS17210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CN538_RS17215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CN538_RS17230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CN538_RS17245	COG1254	Belongs to the acylphosphatase family
CN538_RS17260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CN538_RS17270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CN538_RS17295	COG1970	mechanosensitive ion channel activity
CN538_RS17305	COG2205	protein histidine kinase activity
CN538_RS17310	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CN538_RS17315	COG0483	inositol monophosphate 1-phosphatase activity
CN538_RS17365	COG0509	glycine decarboxylation via glycine cleavage system
CN538_RS17400	COG0776	regulation of translation
CN538_RS17405	COG0072	phenylalanine-tRNA ligase activity
CN538_RS17410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CN538_RS17415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CN538_RS17420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CN538_RS17425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CN538_RS17430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CN538_RS17445	COG1218	3'(2'),5'-bisphosphate nucleotidase
CN538_RS17450	COG0471	metal ion transport
CN538_RS17465	COG1346	cytolysis
CN538_RS17480	COG2755	lipolytic protein G-D-S-L family
CN538_RS17480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CN538_RS17505	COG0517	IMP dehydrogenase activity
CN538_RS17505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CN538_RS17510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CN538_RS17515	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CN538_RS17520	COG3562	capsule polysaccharide
CN538_RS17540	COG2895	sulfate adenylyltransferase (ATP) activity
CN538_RS17545	COG0175	sulfate reduction
CN538_RS17595	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CN538_RS17605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CN538_RS17610	COG0840	transmembrane signaling receptor activity
CN538_RS17650	COG4149	molybdate abc transporter
CN538_RS17660	COG1309	transcriptional regulator
CN538_RS17675	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CN538_RS17675	COG3608	succinylglutamate desuccinylase aspartoacylase
CN538_RS17680	COG0402	S-adenosylhomocysteine deaminase activity
CN538_RS17690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CN538_RS17730	COG3135	benzoate transporter
CN538_RS17790	COG1047	Peptidyl-prolyl cis-trans
CN538_RS17800	COG2211	Major facilitator Superfamily
CN538_RS17830	COG0789	Transcriptional regulator
CN538_RS17835	COG0484	heat shock protein binding
CN538_RS17840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CN538_RS17855	COG3956	TIGRFAM MazG family protein
CN538_RS17860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CN538_RS17865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CN538_RS17875	COG5002	protein histidine kinase activity
CN538_RS17875	COG0784	Response regulator, receiver
CN538_RS17875	COG2205	protein histidine kinase activity
CN538_RS17895	COG0571	ribonuclease III activity
CN538_RS17900	COG0681	Belongs to the peptidase S26 family
CN538_RS17930	COG1199	ATP-dependent helicase activity
CN538_RS17965	COG0811	peptide transport
CN538_RS17970	COG0811	peptide transport
CN538_RS18010	COG0084	hydrolase, TatD family'
CN538_RS18025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CN538_RS18030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CN538_RS18040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CN538_RS18045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CN538_RS18065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CN538_RS18095	COG1530	ribonuclease E activity
CN538_RS18110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CN538_RS18115	COG2835	tetraacyldisaccharide 4'-kinase activity
CN538_RS18125	COG1132	(ABC) transporter
CN538_RS18150	COG2957	Belongs to the agmatine deiminase family
CN538_RS18165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CN538_RS18175	COG1477	protein flavinylation
CN538_RS18180	COG2871	sodium ion transport
CN538_RS18185	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CN538_RS18195	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CN538_RS18205	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CN538_RS18215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CN538_RS18220	COG1408	metallophosphoesterase
CN538_RS18225	COG0069	glutamate synthase activity
CN538_RS18245	COG0469	pyruvate kinase activity
CN538_RS18255	COG0439	Biotin carboxylase
CN538_RS18270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CN538_RS18275	COG0321	lipoyl(octanoyl) transferase activity
CN538_RS18280	COG2921	Belongs to the UPF0250 family
CN538_RS18285	COG1686	Belongs to the peptidase S11 family
CN538_RS18295	COG2951	lytic endotransglycosylase activity
CN538_RS18300	COG0772	Belongs to the SEDS family
CN538_RS18310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CN538_RS18320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CN538_RS18335	COG0586	Pfam SNARE associated Golgi protein
CN538_RS18360	COG3842	ATPase activity
CN538_RS18365	COG3842	ATPase activity
CN538_RS18370	COG3842	ATPase activity
CN538_RS18385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CN538_RS18390	COG0174	glutamine synthetase
CN538_RS18400	COG3134	Outer membrane lipoprotein
CN538_RS18405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN538_RS18430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CN538_RS18485	COG0717	Belongs to the dCTP deaminase family
CN538_RS18490	COG0489	protein tyrosine kinase activity
CN538_RS18500	COG1854	S-ribosylhomocysteine lyase activity
CN538_RS18530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CN538_RS18530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CN538_RS18535	COG2878	Part of a membrane complex involved in electron transport
CN538_RS18540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CN538_RS18545	COG0477	Major facilitator Superfamily
CN538_RS18550	COG1609	Transcriptional regulator
CN538_RS18570	COG0673	inositol 2-dehydrogenase activity
CN538_RS18600	COG0137	argininosuccinate synthase activity
CN538_RS18605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CN538_RS18610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CN538_RS18615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CN538_RS18635	COG1252	NADH dehydrogenase
CN538_RS18655	COG1192	Involved in chromosome partitioning
CN538_RS18670	COG0405	Gamma-glutamyltransferase
CN538_RS18690	COG4208	sulfate ABC transporter
CN538_RS18695	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CN538_RS18710	COG4991	sh3 domain protein
CN538_RS18720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CN538_RS18725	COG1702	phosphate starvation-inducible protein PhoH
CN538_RS18785	COG3250	beta-galactosidase activity
CN538_RS18795	COG3250	beta-galactosidase activity
CN538_RS18840	COG0183	Belongs to the thiolase family
CN538_RS18845	COG1024	Enoyl-CoA hydratase
CN538_RS18845	COG1250	3-hydroxyacyl-CoA dehydrogenase
CN538_RS18865	COG0589	response to stress
CN538_RS18870	COG0488	(ABC) transporter
CN538_RS18875	COG0084	hydrolase, TatD family'
CN538_RS18905	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CN538_RS18960	COG0175	sulfate reduction
CN538_RS18965	COG0583	DNA-binding transcription factor activity
CN538_RS18970	COG3118	belongs to the thioredoxin family
CN538_RS18975	COG0628	permease
CN538_RS18980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CN538_RS18990	COG0573	inorganic phosphate transmembrane transporter activity
CN538_RS19015	COG2853	Lipoprotein
CN538_RS19030	COG0318	PFAM AMP-dependent synthetase and ligase
CN538_RS19050	COG2983	Belongs to the UPF0260 family
CN538_RS19055	COG3100	YcgL domain-containing protein
CN538_RS19065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CN538_RS19070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CN538_RS19075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CN538_RS19115	COG0642	Histidine kinase
CN538_RS19125	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CN538_RS19130	COG1196	nuclear chromosome segregation
CN538_RS19130	COG3264	Mechanosensitive ion channel
CN538_RS19155	COG2081	HI0933 family
CN538_RS19170	COG0776	regulation of translation
CN538_RS19180	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CN538_RS19185	COG0284	orotidine-5'-phosphate decarboxylase activity
CN538_RS19190	COG1596	polysaccharide export
CN538_RS19190	COG1555	photosystem II stabilization
CN538_RS19200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CN538_RS19205	COG0459	protein refolding
CN538_RS19225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CN538_RS19230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CN538_RS19235	COG0077	Prephenate dehydratase
CN538_RS19235	COG1605	Chorismate mutase
CN538_RS19240	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CN538_RS19250	COG0824	Thioesterase
CN538_RS19255	COG2974	May be involved in recombination
CN538_RS19295	COG0237	dephospho-CoA kinase activity
CN538_RS19300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CN538_RS19305	COG0352	thiamine-phosphate diphosphorylase activity
CN538_RS19310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CN538_RS19370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CN538_RS19375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CN538_RS19415	COG0792	nuclease activity
CN538_RS19420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CN538_RS19425	COG2823	Periplasmic or secreted lipoprotein
CN538_RS19430	COG2969	positive regulation of protein catabolic process
CN538_RS19435	COG0625	glutathione transferase activity
CN538_RS19440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CN538_RS19445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CN538_RS19460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CN538_RS19465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CN538_RS19475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CN538_RS19480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CN538_RS19485	COG5007	Belongs to the BolA IbaG family
CN538_RS19500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CN538_RS19505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CN538_RS19510	COG1127	ABC transporter
CN538_RS19540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CN538_RS19575	COG0312	modulator of DNA gyrase
CN538_RS19595	COG0424	maF-like protein
CN538_RS19605	COG1792	Involved in formation and maintenance of cell shape
CN538_RS19610	COG1077	Cell shape determining protein MreB Mrl
CN538_RS19615	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CN538_RS19625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)