locus-tag	class	description
D0Y50_RS00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D0Y50_RS00015	COG0594	ribonuclease P activity
D0Y50_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0Y50_RS00025	COG0706	membrane insertase activity
D0Y50_RS00040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0Y50_RS00065	COG1192	Involved in chromosome partitioning
D0Y50_RS00070	COG1475	DNA binding
D0Y50_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D0Y50_RS00095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0Y50_RS00115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0Y50_RS00150	COG2040	homocysteine
D0Y50_RS00155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D0Y50_RS00180	COG2963	transposase activity
D0Y50_RS00185	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS00200	COG1561	YicC-like family, N-terminal region
D0Y50_RS00215	COG0425	Belongs to the sulfur carrier protein TusA family
D0Y50_RS00270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0Y50_RS00280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0Y50_RS00285	COG0697	spore germination
D0Y50_RS00295	COG1595	DNA-templated transcription, initiation
D0Y50_RS00305	COG2911	Protein conserved in bacteria
D0Y50_RS00310	COG0729	surface antigen
D0Y50_RS00320	COG2814	Major facilitator Superfamily
D0Y50_RS00340	COG2860	membrane
D0Y50_RS00355	COG0129	dihydroxy-acid dehydratase activity
D0Y50_RS00385	COG5002	protein histidine kinase activity
D0Y50_RS00395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0Y50_RS00405	COG0210	DNA helicase
D0Y50_RS00420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0Y50_RS00425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0Y50_RS00430	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D0Y50_RS00435	COG1845	cytochrome c oxidase, subunit III
D0Y50_RS00455	COG1612	heme a metabolic process
D0Y50_RS00460	COG0109	protoheme IX farnesyltransferase activity
D0Y50_RS00480	COG0534	Mate efflux family protein
D0Y50_RS00500	COG1040	competence protein
D0Y50_RS00505	COG0596	Alpha beta hydrolase
D0Y50_RS00520	COG2183	response to ionizing radiation
D0Y50_RS00535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y50_RS00545	COG0545	Peptidyl-prolyl cis-trans isomerase
D0Y50_RS00555	COG2900	Belongs to the SlyX family
D0Y50_RS00580	COG0488	(ABC) transporter
D0Y50_RS00590	COG0429	hydrolase of the alpha beta-hydrolase fold
D0Y50_RS00595	COG3089	Belongs to the UPF0270 family
D0Y50_RS00600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0Y50_RS00615	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D0Y50_RS00620	COG2943	transferase activity, transferring hexosyl groups
D0Y50_RS00630	COG0789	Transcriptional regulator
D0Y50_RS00635	COG4771	TonB-dependent receptor
D0Y50_RS00645	COG1218	3'(2'),5'-bisphosphate nucleotidase
D0Y50_RS00650	COG0494	nUDIX hydrolase
D0Y50_RS00655	COG1011	Hydrolase
D0Y50_RS00660	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D0Y50_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
D0Y50_RS00675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0Y50_RS00690	COG4795	General secretion pathway protein
D0Y50_RS00695	COG2165	general secretion pathway protein
D0Y50_RS00705	COG2165	general secretion pathway protein
D0Y50_RS00710	COG1459	type II secretion system
D0Y50_RS00715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0Y50_RS00725	COG3031	protein transport across the cell outer membrane
D0Y50_RS00735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D0Y50_RS00745	COG0583	DNA-binding transcription factor activity
D0Y50_RS00750	COG1902	pentaerythritol trinitrate reductase activity
D0Y50_RS00755	COG1979	alcohol dehydrogenase
D0Y50_RS00785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0Y50_RS00790	COG3954	Phosphoribulokinase
D0Y50_RS00810	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D0Y50_RS00815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Y50_RS00830	COG0154	amidase activity
D0Y50_RS00855	COG2176	DNA-directed DNA polymerase activity
D0Y50_RS00870	COG0439	Biotin carboxylase
D0Y50_RS00875	COG0511	ligase activity, forming carbon-carbon bonds
D0Y50_RS00880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0Y50_RS00885	COG0739	heme binding
D0Y50_RS00890	COG4232	protein-disulfide reductase activity
D0Y50_RS00935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0Y50_RS00940	COG0583	DNA-binding transcription factor activity
D0Y50_RS00945	COG2259	Doxx family
D0Y50_RS00950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0Y50_RS00955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D0Y50_RS00960	COG2080	2 iron, 2 sulfur cluster binding
D0Y50_RS00970	COG1166	arginine decarboxylase activity
D0Y50_RS00980	COG4977	sequence-specific DNA binding
D0Y50_RS00985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0Y50_RS00990	COG0697	spore germination
D0Y50_RS00995	COG2203	Gaf domain
D0Y50_RS00995	COG2199	diguanylate cyclase activity
D0Y50_RS01005	COG0673	inositol 2-dehydrogenase activity
D0Y50_RS01010	COG1349	DNA-binding transcription factor activity
D0Y50_RS01015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Y50_RS01040	COG0583	DNA-binding transcription factor activity
D0Y50_RS01045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0Y50_RS01060	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D0Y50_RS01080	COG0789	Transcriptional regulator
D0Y50_RS01085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0Y50_RS01095	COG0656	L-ascorbic acid biosynthetic process
D0Y50_RS01100	COG2814	Major facilitator Superfamily
D0Y50_RS01105	COG0583	DNA-binding transcription factor activity
D0Y50_RS01110	COG0640	Transcriptional regulator
D0Y50_RS01120	COG0798	PFAM Bile acid sodium symporter
D0Y50_RS01155	COG2267	carboxylic ester hydrolase activity
D0Y50_RS01165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0Y50_RS01180	COG1252	NADH dehydrogenase
D0Y50_RS01220	COG2200	EAL domain
D0Y50_RS01220	COG2199	diguanylate cyclase activity
D0Y50_RS01220	COG2202	Pas domain
D0Y50_RS01245	COG1566	PFAM secretion protein HlyD family protein
D0Y50_RS01275	COG4191	Histidine kinase
D0Y50_RS01280	COG0840	transmembrane signaling receptor activity
D0Y50_RS01290	COG1136	(ABC) transporter
D0Y50_RS01290	COG0577	efflux transmembrane transporter activity
D0Y50_RS01300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0Y50_RS01315	COG3292	Two component regulator propeller
D0Y50_RS01315	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS01315	COG2205	protein histidine kinase activity
D0Y50_RS01340	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS01360	COG0051	transcription antitermination factor activity, RNA binding
D0Y50_RS01375	COG0089	rRNA binding
D0Y50_RS01385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0Y50_RS01395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0Y50_RS01410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0Y50_RS01420	COG0438	transferase activity, transferring glycosyl groups
D0Y50_RS01430	COG1519	Transferase
D0Y50_RS01435	COG3263	regulation of cellular component size
D0Y50_RS01460	COG0788	formyltetrahydrofolate deformylase activity
D0Y50_RS01470	COG1643	Atp-dependent helicase
D0Y50_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS01480	COG2951	lytic endotransglycosylase activity
D0Y50_RS01510	COG3243	poly(R)-hydroxyalkanoic acid synthase
D0Y50_RS01520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Y50_RS01530	COG2354	Protein conserved in bacteria
D0Y50_RS01545	COG0004	ammonium transporteR
D0Y50_RS01550	COG0753	catalase activity
D0Y50_RS01560	COG0405	Gamma-glutamyltransferase
D0Y50_RS01565	COG2837	iron assimilation
D0Y50_RS01580	COG0540	Belongs to the ATCase OTCase family
D0Y50_RS01590	COG5002	protein histidine kinase activity
D0Y50_RS01590	COG2205	protein histidine kinase activity
D0Y50_RS01590	COG0784	Response regulator, receiver
D0Y50_RS01595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0Y50_RS01635	COG1012	belongs to the aldehyde dehydrogenase family
D0Y50_RS01645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Y50_RS01655	COG0512	Glutamine amidotransferase of anthranilate synthase
D0Y50_RS01660	COG0180	Tryptophanyl-tRNA synthetase
D0Y50_RS01665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0Y50_RS01685	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0Y50_RS01690	COG3706	GGDEF domain
D0Y50_RS01690	COG2203	Gaf domain
D0Y50_RS01690	COG4251	negative regulation of phosphorylation
D0Y50_RS01690	COG5001	Diguanylate cyclase
D0Y50_RS01700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D0Y50_RS01735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D0Y50_RS01740	COG0281	malic enzyme
D0Y50_RS01745	COG0625	glutathione transferase activity
D0Y50_RS01755	COG2119	membrane
D0Y50_RS01770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0Y50_RS01770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0Y50_RS01780	COG0137	argininosuccinate synthase activity
D0Y50_RS01800	COG1803	Methylglyoxal synthase
D0Y50_RS01810	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS01815	COG2205	protein histidine kinase activity
D0Y50_RS01820	COG2267	carboxylic ester hydrolase activity
D0Y50_RS01825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0Y50_RS01860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0Y50_RS01870	COG4942	peptidase
D0Y50_RS01875	COG2861	carbohydrate metabolic process
D0Y50_RS01885	COG0584	glycerophosphoryl diester phosphodiesterase
D0Y50_RS01900	COG1162	GTPase activity
D0Y50_RS01905	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D0Y50_RS01930	COG0457	Tetratricopeptide repeat
D0Y50_RS01945	COG0028	Belongs to the TPP enzyme family
D0Y50_RS01965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Y50_RS01970	COG0805	protein transport
D0Y50_RS01980	COG0084	hydrolase, TatD family'
D0Y50_RS01995	COG0248	Ppx GppA phosphatase
D0Y50_RS02000	COG0513	Belongs to the DEAD box helicase family
D0Y50_RS02005	COG3118	belongs to the thioredoxin family
D0Y50_RS02010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0Y50_RS02015	COG1473	amidohydrolase
D0Y50_RS02025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0Y50_RS02030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0Y50_RS02045	COG0783	Belongs to the Dps family
D0Y50_RS02050	COG2133	pyrroloquinoline quinone binding
D0Y50_RS02060	COG0823	Involved in the tonB-independent uptake of proteins
D0Y50_RS02060	COG1506	peptidase
D0Y50_RS02060	COG4946	Tricorn protease homolog
D0Y50_RS02070	COG3118	belongs to the thioredoxin family
D0Y50_RS02085	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D0Y50_RS02095	COG1012	belongs to the aldehyde dehydrogenase family
D0Y50_RS02110	COG1757	Na H antiporter
D0Y50_RS02115	COG3023	N-Acetylmuramoyl-L-alanine amidase
D0Y50_RS02135	COG3876	Protein conserved in bacteria
D0Y50_RS02140	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0Y50_RS02175	COG0463	Glycosyl transferase, family 2
D0Y50_RS02215	COG3152	Membrane
D0Y50_RS02260	COG0840	transmembrane signaling receptor activity
D0Y50_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS02270	COG0431	NADPH-dependent FMN reductase
D0Y50_RS02280	COG0183	Belongs to the thiolase family
D0Y50_RS02285	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Y50_RS02285	COG1024	Enoyl-CoA hydratase
D0Y50_RS02290	COG0741	lytic transglycosylase activity
D0Y50_RS02310	COG0006	proline dipeptidase activity
D0Y50_RS02320	COG0142	geranyltranstransferase activity
D0Y50_RS02355	COG1238	metal cluster binding
D0Y50_RS02365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D0Y50_RS02370	COG0585	pseudouridine synthase activity
D0Y50_RS02375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D0Y50_RS02385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D0Y50_RS02395	COG0840	transmembrane signaling receptor activity
D0Y50_RS02400	COG0506	proline dehydrogenase activity
D0Y50_RS02400	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0Y50_RS02400	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0Y50_RS02410	COG3025	triphosphatase activity
D0Y50_RS02420	COG3066	DNA modification
D0Y50_RS02425	COG0494	nUDIX hydrolase
D0Y50_RS02430	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
D0Y50_RS02435	COG0730	response to heat
D0Y50_RS02440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0Y50_RS02445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D0Y50_RS02460	COG3437	response regulator, receiver
D0Y50_RS02460	COG4999	Histidine kinase
D0Y50_RS02460	COG2205	protein histidine kinase activity
D0Y50_RS02460	COG3850	Histidine kinase
D0Y50_RS02465	COG2211	Major facilitator Superfamily
D0Y50_RS02485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0Y50_RS02490	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0Y50_RS02500	COG1648	precorrin-2 dehydrogenase activity
D0Y50_RS02500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0Y50_RS02505	COG0513	Belongs to the DEAD box helicase family
D0Y50_RS02520	COG1538	Outer membrane efflux protein
D0Y50_RS02525	COG0494	nUDIX hydrolase
D0Y50_RS02530	COG3151	Protein conserved in bacteria
D0Y50_RS02535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0Y50_RS02540	COG3150	esterase
D0Y50_RS02555	COG4251	negative regulation of phosphorylation
D0Y50_RS02565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y50_RS02580	COG1509	lysine 2,3-aminomutase activity
D0Y50_RS02585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0Y50_RS02625	COG0271	Belongs to the BolA IbaG family
D0Y50_RS02635	COG0671	phosphoesterase, PA-phosphatase related
D0Y50_RS02650	COG0659	secondary active sulfate transmembrane transporter activity
D0Y50_RS02655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0Y50_RS02660	COG0656	L-ascorbic acid biosynthetic process
D0Y50_RS02675	COG0701	Predicted permease
D0Y50_RS02680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0Y50_RS02695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0Y50_RS02700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Y50_RS02710	COG3706	GGDEF domain
D0Y50_RS02710	COG5001	Diguanylate cyclase
D0Y50_RS02710	COG2203	Gaf domain
D0Y50_RS02710	COG4251	negative regulation of phosphorylation
D0Y50_RS02715	COG4206	TonB-dependent receptor
D0Y50_RS02730	COG0348	domain, Protein
D0Y50_RS02745	COG2356	endonuclease I
D0Y50_RS02750	COG1960	acyl-CoA dehydrogenase activity
D0Y50_RS02770	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS02795	COG0366	Alpha amylase catalytic
D0Y50_RS02800	COG4948	Mandelate Racemase Muconate Lactonizing
D0Y50_RS02820	COG0500	methyltransferase
D0Y50_RS02825	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Y50_RS02830	COG4948	Mandelate Racemase Muconate Lactonizing
D0Y50_RS02840	COG2153	protein acetylation
D0Y50_RS02850	COG0358	DNA primase activity
D0Y50_RS02855	COG1610	YqeY-like protein
D0Y50_RS02875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D0Y50_RS02885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0Y50_RS02895	COG0537	adenosine 5'-monophosphoramidase activity
D0Y50_RS02935	COG3135	benzoate transporter
D0Y50_RS02940	COG1396	sequence-specific DNA binding
D0Y50_RS02950	COG2974	May be involved in recombination
D0Y50_RS02955	COG2205	protein histidine kinase activity
D0Y50_RS02960	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS02965	COG5002	protein histidine kinase activity
D0Y50_RS02995	COG0811	peptide transport
D0Y50_RS03000	COG0811	peptide transport
D0Y50_RS03005	COG0848	biopolymer transport protein
D0Y50_RS03010	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D0Y50_RS03025	COG3850	Histidine kinase
D0Y50_RS03025	COG4999	Histidine kinase
D0Y50_RS03025	COG2205	protein histidine kinase activity
D0Y50_RS03025	COG3437	response regulator, receiver
D0Y50_RS03045	COG2133	pyrroloquinoline quinone binding
D0Y50_RS03060	COG0527	aspartate kinase activity
D0Y50_RS03070	COG0840	transmembrane signaling receptor activity
D0Y50_RS03075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0Y50_RS03080	COG2967	ApaG domain
D0Y50_RS03085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0Y50_RS03090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0Y50_RS03095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0Y50_RS03100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0Y50_RS03105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0Y50_RS03110	COG4974	Belongs to the 'phage' integrase family
D0Y50_RS03115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0Y50_RS03120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0Y50_RS03135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D0Y50_RS03140	COG0736	holo-[acyl-carrier-protein] synthase activity
D0Y50_RS03145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0Y50_RS03150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Y50_RS03155	COG3956	TIGRFAM MazG family protein
D0Y50_RS03170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0Y50_RS03175	COG0723	plastoquinol--plastocyanin reductase activity
D0Y50_RS03180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0Y50_RS03185	COG2857	Cytochrome c1
D0Y50_RS03190	COG0625	glutathione transferase activity
D0Y50_RS03195	COG2969	positive regulation of protein catabolic process
D0Y50_RS03210	COG2239	Acts as a magnesium transporter
D0Y50_RS03215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y50_RS03235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D0Y50_RS03240	COG1137	ATPase activity
D0Y50_RS03255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D0Y50_RS03275	COG1127	ABC transporter
D0Y50_RS03280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0Y50_RS03285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0Y50_RS03290	COG2854	intermembrane phospholipid transfer
D0Y50_RS03300	COG5007	Belongs to the BolA IbaG family
D0Y50_RS03310	COG2205	protein histidine kinase activity
D0Y50_RS03315	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS03325	COG3713	MltA-interacting MipA family protein
D0Y50_RS03340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Y50_RS03350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0Y50_RS03375	COG5001	Diguanylate cyclase
D0Y50_RS03420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0Y50_RS03435	COG2205	protein histidine kinase activity
D0Y50_RS03435	COG0784	Response regulator, receiver
D0Y50_RS03450	COG1794	racemase activity, acting on amino acids and derivatives
D0Y50_RS03470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0Y50_RS03480	COG0126	phosphoglycerate kinase activity
D0Y50_RS03485	COG3588	fructose-bisphosphate aldolase
D0Y50_RS03490	COG3706	GGDEF domain
D0Y50_RS03495	COG0248	Ppx GppA phosphatase
D0Y50_RS03500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0Y50_RS03530	COG0306	phosphate transporter
D0Y50_RS03535	COG0589	response to stress
D0Y50_RS03545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0Y50_RS03560	COG0489	protein tyrosine kinase activity
D0Y50_RS03590	COG0297	glycogen (starch) synthase activity
D0Y50_RS03615	COG1215	transferase activity, transferring glycosyl groups
D0Y50_RS03645	COG1272	protein, Hemolysin III
D0Y50_RS03655	COG1846	Transcriptional regulator
D0Y50_RS03660	COG1764	response to oxidative stress
D0Y50_RS03665	COG1739	Uncharacterized protein family UPF0029
D0Y50_RS03675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D0Y50_RS03720	COG1230	cation diffusion facilitator family transporter
D0Y50_RS03750	COG0488	(ABC) transporter
D0Y50_RS03890	COG3279	Response regulator of the LytR AlgR family
D0Y50_RS03900	COG1346	cytolysis
D0Y50_RS03930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0Y50_RS03940	COG0513	Belongs to the DEAD box helicase family
D0Y50_RS03950	COG3409	Peptidoglycan-binding domain 1 protein
D0Y50_RS03950	COG3267	Type II secretory pathway component ExeA
D0Y50_RS03975	COG0473	3-isopropylmalate dehydrogenase activity
D0Y50_RS03980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0Y50_RS04015	COG4221	oxidoreductase activity
D0Y50_RS04050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0Y50_RS04055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y50_RS04060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0Y50_RS04060	COG1017	nitric oxide dioxygenase activity
D0Y50_RS04065	COG3604	Transcriptional regulator
D0Y50_RS04080	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS04085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0Y50_RS04110	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0Y50_RS04120	COG4133	protoheme IX ABC transporter activity
D0Y50_RS04125	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0Y50_RS04130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0Y50_RS04145	COG1138	Cytochrome C-type biogenesis protein
D0Y50_RS04150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Y50_RS04155	COG3088	subunit of a heme lyase
D0Y50_RS04155	COG4235	cytochrome complex assembly
D0Y50_RS04165	COG2853	Lipoprotein
D0Y50_RS04170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0Y50_RS04180	COG3104	oligopeptide transport
D0Y50_RS04190	COG1091	dTDP-4-dehydrorhamnose reductase activity
D0Y50_RS04200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D0Y50_RS04250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0Y50_RS04260	COG0473	3-isopropylmalate dehydrogenase activity
D0Y50_RS04275	COG1611	Belongs to the LOG family
D0Y50_RS04285	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0Y50_RS04285	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0Y50_RS04335	COG0716	FMN binding
D0Y50_RS04345	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0Y50_RS04350	COG0024	Methionine aminopeptidase
D0Y50_RS04355	COG0052	Belongs to the universal ribosomal protein uS2 family
D0Y50_RS04365	COG0528	UMP kinase activity
D0Y50_RS04380	COG0575	Belongs to the CDS family
D0Y50_RS04385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0Y50_RS04405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0Y50_RS04410	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Y50_RS04425	COG0587	DNA-directed DNA polymerase activity
D0Y50_RS04430	COG0825	malonyl-CoA metabolic process
D0Y50_RS04435	COG0037	tRNA processing
D0Y50_RS04465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0Y50_RS04465	COG0047	phosphoribosylformylglycinamidine synthase activity
D0Y50_RS04470	COG2840	Smr protein MutS2
D0Y50_RS04505	COG0835	chemotaxis
D0Y50_RS04505	COG0784	Response regulator, receiver
D0Y50_RS04510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D0Y50_RS04515	COG1815	bacterial-type flagellum-dependent cell motility
D0Y50_RS04525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0Y50_RS04535	COG4787	bacterial-type flagellum-dependent cell motility
D0Y50_RS04555	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0Y50_RS04555	COG3951	Flagellar rod assembly protein muramidase FlgJ
D0Y50_RS04560	COG1256	bacterial-type flagellum assembly
D0Y50_RS04565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0Y50_RS04570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0Y50_RS04580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0Y50_RS04610	COG1086	Polysaccharide biosynthesis protein
D0Y50_RS04615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0Y50_RS04620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0Y50_RS04630	COG1216	Glycosyl transferase, family 2
D0Y50_RS04640	COG2226	methyltransferase
D0Y50_RS04655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0Y50_RS04660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0Y50_RS04660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0Y50_RS04680	COG3475	LICD family
D0Y50_RS04685	COG2089	acid synthase
D0Y50_RS04695	COG1083	cytidylyl-transferase
D0Y50_RS04720	COG1677	Flagellar hook-basal body complex protein FliE
D0Y50_RS04725	COG1766	The M ring may be actively involved in energy transduction
D0Y50_RS04730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0Y50_RS04780	COG1987	bacterial-type flagellum assembly
D0Y50_RS04795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0Y50_RS04820	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D0Y50_RS04825	COG2198	Histidine kinase
D0Y50_RS04825	COG0784	Response regulator, receiver
D0Y50_RS04825	COG0643	Histidine kinase
D0Y50_RS04830	COG2201	protein-glutamate methylesterase activity
D0Y50_RS04835	COG1192	Involved in chromosome partitioning
D0Y50_RS04845	COG0835	chemotaxis
D0Y50_RS04900	COG2801	Transposase and inactivated derivatives
D0Y50_RS04905	COG4584	PFAM Integrase catalytic
D0Y50_RS04910	COG1484	DNA-dependent DNA replication
D0Y50_RS04915	COG2801	Transposase and inactivated derivatives
D0Y50_RS04920	COG2801	Transposase and inactivated derivatives
D0Y50_RS04935	COG1410	methionine synthase
D0Y50_RS04935	COG0646	methionine synthase
D0Y50_RS04955	COG0583	DNA-binding transcription factor activity
D0Y50_RS04960	COG0583	DNA-binding transcription factor activity
D0Y50_RS04965	COG0288	reversible hydration of carbon dioxide
D0Y50_RS04970	COG0288	reversible hydration of carbon dioxide
D0Y50_RS04975	COG0659	secondary active sulfate transmembrane transporter activity
D0Y50_RS04980	COG0668	transmembrane transport
D0Y50_RS04995	COG3590	peptidase
D0Y50_RS05005	COG2137	regulation of response to DNA damage stimulus
D0Y50_RS05010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0Y50_RS05035	COG3630	sodium ion export across plasma membrane
D0Y50_RS05045	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D0Y50_RS05050	COG4172	Belongs to the ABC transporter superfamily
D0Y50_RS05055	COG4172	Belongs to the ABC transporter superfamily
D0Y50_RS05065	COG4168	peptide transport system, permease
D0Y50_RS05070	COG0747	negative chemotaxis
D0Y50_RS05075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0Y50_RS05080	COG1842	Phage shock protein A
D0Y50_RS05090	COG1983	PspC domain protein
D0Y50_RS05110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D0Y50_RS05120	COG0625	glutathione transferase activity
D0Y50_RS05125	COG1522	sequence-specific DNA binding
D0Y50_RS05170	COG0811	peptide transport
D0Y50_RS05175	COG0811	peptide transport
D0Y50_RS05180	COG0848	biopolymer transport protein
D0Y50_RS05260	COG0517	IMP dehydrogenase activity
D0Y50_RS05290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0Y50_RS05295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0Y50_RS05300	COG0564	pseudouridine synthase activity
D0Y50_RS05310	COG0612	Peptidase, M16
D0Y50_RS05315	COG2918	glutathione biosynthetic process
D0Y50_RS05330	COG2840	Smr protein MutS2
D0Y50_RS05335	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Y50_RS05355	COG2719	SpoVR family
D0Y50_RS05360	COG2718	Belongs to the UPF0229 family
D0Y50_RS05365	COG2766	serine protein kinase
D0Y50_RS05375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0Y50_RS05380	COG4771	TonB-dependent receptor
D0Y50_RS05395	COG4206	TonB-dependent receptor
D0Y50_RS05405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0Y50_RS05415	COG0584	glycerophosphoryl diester phosphodiesterase
D0Y50_RS05420	COG0346	lactoylglutathione lyase activity
D0Y50_RS05425	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS05470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0Y50_RS05475	COG4660	Part of a membrane complex involved in electron transport
D0Y50_RS05480	COG4659	FMN binding
D0Y50_RS05485	COG4658	electron transport chain
D0Y50_RS05490	COG4656	Part of a membrane complex involved in electron transport
D0Y50_RS05495	COG2878	Part of a membrane complex involved in electron transport
D0Y50_RS05500	COG4657	Part of a membrane complex involved in electron transport
D0Y50_RS05515	COG0534	Mate efflux family protein
D0Y50_RS05520	COG0556	nucleotide-excision repair
D0Y50_RS05535	COG0602	queuosine metabolic process
D0Y50_RS05550	COG0367	asparagine synthase
D0Y50_RS05570	COG4555	ABC transporter
D0Y50_RS05575	COG1668	transmembrane transport
D0Y50_RS05580	COG3273	potassium ion transport
D0Y50_RS05580	COG0471	metal ion transport
D0Y50_RS05595	COG0529	Catalyzes the synthesis of activated sulfate
D0Y50_RS05600	COG0175	sulfate reduction
D0Y50_RS05605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Y50_RS05615	COG1595	DNA-templated transcription, initiation
D0Y50_RS05630	COG2304	oxidoreductase activity
D0Y50_RS05650	COG0714	Associated with various cellular activities
D0Y50_RS05660	COG1024	Enoyl-CoA hydratase
D0Y50_RS05660	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Y50_RS05675	COG1025	Belongs to the peptidase M16 family
D0Y50_RS05690	COG4536	flavin adenine dinucleotide binding
D0Y50_RS05695	COG4137	Cytochrome C assembly protein
D0Y50_RS05700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0Y50_RS05720	COG0583	DNA-binding transcription factor activity
D0Y50_RS05750	COG1132	(ABC) transporter
D0Y50_RS05755	COG0228	four-way junction DNA binding
D0Y50_RS05760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0Y50_RS05765	COG0336	Belongs to the RNA methyltransferase TrmD family
D0Y50_RS05770	COG0335	large ribosomal subunit rRNA binding
D0Y50_RS05780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0Y50_RS05785	COG1605	Chorismate mutase
D0Y50_RS05785	COG0287	Prephenate dehydrogenase
D0Y50_RS05790	COG1605	Chorismate mutase
D0Y50_RS05790	COG0077	Prephenate dehydratase
D0Y50_RS05795	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS05800	COG0023	Translation Initiation Factor
D0Y50_RS05810	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS05830	COG2205	protein histidine kinase activity
D0Y50_RS05840	COG2204	response regulator
D0Y50_RS05845	COG1801	Protein of unknown function DUF72
D0Y50_RS05850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0Y50_RS05855	COG0494	nUDIX hydrolase
D0Y50_RS05860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D0Y50_RS05865	COG0632	four-way junction helicase activity
D0Y50_RS05870	COG2255	four-way junction helicase activity
D0Y50_RS05875	COG0824	Thioesterase
D0Y50_RS05880	COG0811	peptide transport
D0Y50_RS05895	COG0823	Involved in the tonB-independent uptake of proteins
D0Y50_RS05900	COG2885	chlorophyll binding
D0Y50_RS05905	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D0Y50_RS05925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D0Y50_RS05950	COG0604	alcohol dehydrogenase
D0Y50_RS05965	COG0339	signal peptide processing
D0Y50_RS05990	COG2223	nitrite transmembrane transporter activity
D0Y50_RS06000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0Y50_RS06005	COG0604	alcohol dehydrogenase
D0Y50_RS06005	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS06005	COG3321	synthase
D0Y50_RS06030	COG3008	intermembrane lipid transfer
D0Y50_RS06030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0Y50_RS06035	COG2995	paraquat-inducible protein a
D0Y50_RS06040	COG0017	Asparaginyl-tRNA synthetase
D0Y50_RS06080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0Y50_RS06090	COG0156	8-amino-7-oxononanoate synthase activity
D0Y50_RS06095	COG2226	methyltransferase
D0Y50_RS06105	COG3340	Belongs to the peptidase S51 family
D0Y50_RS06115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Y50_RS06120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0Y50_RS06130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D0Y50_RS06205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0Y50_RS06275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Y50_RS06290	COG2755	lipolytic protein G-D-S-L family
D0Y50_RS06295	COG4181	ATPase activity
D0Y50_RS06300	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D0Y50_RS06315	COG2226	methyltransferase
D0Y50_RS06365	COG1090	epimerase
D0Y50_RS06370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0Y50_RS06375	COG0628	permease
D0Y50_RS06400	COG2350	Protein conserved in bacteria
D0Y50_RS06415	COG0135	phosphoribosylanthranilate isomerase activity
D0Y50_RS06415	COG0134	indole-3-glycerol-phosphate synthase activity
D0Y50_RS06420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0Y50_RS06430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0Y50_RS06435	COG0613	PHP domain protein
D0Y50_RS06440	COG0009	L-threonylcarbamoyladenylate synthase
D0Y50_RS06445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D0Y50_RS06450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D0Y50_RS06460	COG0656	L-ascorbic acid biosynthetic process
D0Y50_RS06465	COG2733	membrane
D0Y50_RS06470	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D0Y50_RS06480	COG0583	DNA-binding transcription factor activity
D0Y50_RS06495	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y50_RS06500	COG0497	DNA recombination
D0Y50_RS06515	COG0583	DNA-binding transcription factor activity
D0Y50_RS06545	COG4763	Acyl-transferase
D0Y50_RS06550	COG2066	Belongs to the glutaminase family
D0Y50_RS06580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0Y50_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS06595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0Y50_RS06600	COG2610	gluconate transmembrane transporter activity
D0Y50_RS06605	COG4771	TonB-dependent receptor
D0Y50_RS06615	COG2198	Histidine kinase
D0Y50_RS06615	COG2205	protein histidine kinase activity
D0Y50_RS06615	COG0784	Response regulator, receiver
D0Y50_RS06620	COG4771	TonB-dependent receptor
D0Y50_RS06625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D0Y50_RS06635	COG0484	heat shock protein binding
D0Y50_RS06685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0Y50_RS06690	COG0505	Belongs to the CarA family
D0Y50_RS06695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0Y50_RS06700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y50_RS06715	COG1714	RDD family
D0Y50_RS06725	COG1228	amidohydrolase
D0Y50_RS06730	COG1982	Orn Lys Arg decarboxylase major
D0Y50_RS06735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D0Y50_RS06740	COG4535	Mg2 and Co2 transporter CorC
D0Y50_RS06750	COG1702	phosphate starvation-inducible protein PhoH
D0Y50_RS06760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Y50_RS06765	COG1309	transcriptional regulator
D0Y50_RS06780	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS06785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Y50_RS06795	COG1538	Outer membrane efflux protein
D0Y50_RS06800	COG1115	amino acid carrier protein
D0Y50_RS06845	COG3693	PFAM glycoside hydrolase, family 10
D0Y50_RS06865	COG4774	siderophore transport
D0Y50_RS06905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0Y50_RS06915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0Y50_RS06920	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D0Y50_RS06925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D0Y50_RS06935	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Y50_RS06955	COG0583	DNA-binding transcription factor activity
D0Y50_RS06965	COG2363	Small membrane protein
D0Y50_RS06995	COG0714	Associated with various cellular activities
D0Y50_RS07000	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D0Y50_RS07005	COG0033	Phosphoglucomutase
D0Y50_RS07010	COG0058	SHG alpha-glucan phosphorylase activity
D0Y50_RS07035	COG2207	Transcriptional regulator
D0Y50_RS07040	COG2814	Major facilitator Superfamily
D0Y50_RS07045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0Y50_RS07060	COG2207	Transcriptional regulator
D0Y50_RS07080	COG1012	belongs to the aldehyde dehydrogenase family
D0Y50_RS07090	COG2988	succinylglutamate desuccinylase activity
D0Y50_RS07110	COG1876	peptidase activity
D0Y50_RS07120	COG1393	Belongs to the ArsC family
D0Y50_RS07125	COG1764	response to oxidative stress
D0Y50_RS07145	COG2808	Putative FMN-binding domain
D0Y50_RS07170	COG1621	beta-fructofuranosidase activity
D0Y50_RS07180	COG0402	S-adenosylhomocysteine deaminase activity
D0Y50_RS07185	COG2351	hydroxyisourate hydrolase activity
D0Y50_RS07200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0Y50_RS07210	COG1309	transcriptional regulator
D0Y50_RS07225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D0Y50_RS07230	COG2252	PERMEase
D0Y50_RS07240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0Y50_RS07245	COG3665	Urea carboxylase-associated protein
D0Y50_RS07270	COG0438	transferase activity, transferring glycosyl groups
D0Y50_RS07280	COG2323	membrane
D0Y50_RS07295	COG2233	PERMEase
D0Y50_RS07300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0Y50_RS07315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0Y50_RS07320	COG0730	response to heat
D0Y50_RS07330	COG0154	amidase activity
D0Y50_RS07360	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS07365	COG3001	Fructosamine kinase
D0Y50_RS07395	COG0072	phenylalanine-tRNA ligase activity
D0Y50_RS07400	COG0776	regulation of translation
D0Y50_RS07415	COG0431	NADPH-dependent FMN reductase
D0Y50_RS07420	COG0640	Transcriptional regulator
D0Y50_RS07450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0Y50_RS07460	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Y50_RS07465	COG0471	metal ion transport
D0Y50_RS07470	COG2096	Adenosyltransferase
D0Y50_RS07480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0Y50_RS07490	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0Y50_RS07505	COG0708	Exodeoxyribonuclease III
D0Y50_RS07515	COG4251	negative regulation of phosphorylation
D0Y50_RS07575	COG1957	nucleoside hydrolase
D0Y50_RS07600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Y50_RS07605	COG0789	Transcriptional regulator
D0Y50_RS07620	COG2200	EAL domain
D0Y50_RS07620	COG2199	diguanylate cyclase activity
D0Y50_RS07630	COG4770	biotin carboxylase activity
D0Y50_RS07640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0Y50_RS07645	COG1960	acyl-CoA dehydrogenase activity
D0Y50_RS07650	COG0789	Transcriptional regulator
D0Y50_RS07655	COG0183	Belongs to the thiolase family
D0Y50_RS07690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Y50_RS07700	COG4134	Bacterial extracellular solute-binding protein
D0Y50_RS07705	COG4135	transport system, permease component
D0Y50_RS07710	COG4136	ATPase activity
D0Y50_RS07715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0Y50_RS07730	COG2925	Exonuclease
D0Y50_RS07755	COG2199	diguanylate cyclase activity
D0Y50_RS07755	COG2203	Gaf domain
D0Y50_RS07780	COG3321	synthase
D0Y50_RS07780	COG0604	alcohol dehydrogenase
D0Y50_RS07790	COG0328	RNA-DNA hybrid ribonuclease activity
D0Y50_RS07825	COG1136	(ABC) transporter
D0Y50_RS07830	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0Y50_RS07835	COG1301	dicarboxylic acid transport
D0Y50_RS07845	COG3724	N-succinylarginine dihydrolase activity
D0Y50_RS07875	COG1671	Belongs to the UPF0178 family
D0Y50_RS07880	COG0385	Bile acid
D0Y50_RS07890	COG0583	DNA-binding transcription factor activity
D0Y50_RS07900	COG1530	ribonuclease E activity
D0Y50_RS07905	COG0564	pseudouridine synthase activity
D0Y50_RS07915	COG0424	maF-like protein
D0Y50_RS07920	COG1399	metal-binding, possibly nucleic acid-binding protein
D0Y50_RS07930	COG0416	fatty acid biosynthetic process
D0Y50_RS07935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Y50_RS07940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0Y50_RS07950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Y50_RS07955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Y50_RS07960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0Y50_RS07965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0Y50_RS07975	COG0470	DNA polymerase III
D0Y50_RS07980	COG0084	hydrolase, TatD family'
D0Y50_RS08005	COG0702	epimerase
D0Y50_RS08015	COG0753	catalase activity
D0Y50_RS08020	COG3012	SEC-C Motif Domain Protein
D0Y50_RS08035	COG5265	(ABC) transporter
D0Y50_RS08055	COG1629	transport
D0Y50_RS08065	COG0657	acetylesterase activity
D0Y50_RS08080	COG1757	Na H antiporter
D0Y50_RS08105	COG2801	Transposase and inactivated derivatives
D0Y50_RS08165	COG4771	TonB-dependent receptor
D0Y50_RS08170	COG0702	epimerase
D0Y50_RS08175	COG2814	Major facilitator Superfamily
D0Y50_RS08180	COG1621	beta-fructofuranosidase activity
D0Y50_RS08190	COG1609	Transcriptional regulator
D0Y50_RS08195	COG3300	MHYT domain
D0Y50_RS08195	COG5001	Diguanylate cyclase
D0Y50_RS08220	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D0Y50_RS08225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0Y50_RS08230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Y50_RS08235	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0Y50_RS08260	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS08265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0Y50_RS08275	COG2814	Major facilitator Superfamily
D0Y50_RS08295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D0Y50_RS08300	COG0436	Aminotransferase
D0Y50_RS08315	COG1765	OsmC-like protein
D0Y50_RS08320	COG2996	Protein conserved in bacteria
D0Y50_RS08325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D0Y50_RS08335	COG1984	allophanate hydrolase subunit 2
D0Y50_RS08345	COG0735	belongs to the Fur family
D0Y50_RS08355	COG0716	FMN binding
D0Y50_RS08365	COG0596	Alpha beta hydrolase
D0Y50_RS08415	COG4977	sequence-specific DNA binding
D0Y50_RS08420	COG2130	NADP-dependent
D0Y50_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS08430	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS08435	COG1448	Aminotransferase
D0Y50_RS08445	COG2873	o-acetylhomoserine
D0Y50_RS08475	COG1024	Enoyl-CoA hydratase
D0Y50_RS08480	COG0405	Gamma-glutamyltransferase
D0Y50_RS08490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0Y50_RS08495	COG3604	Transcriptional regulator
D0Y50_RS08505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D0Y50_RS08510	COG2068	MobA-Related Protein
D0Y50_RS08520	COG2095	MarC family integral membrane protein
D0Y50_RS08525	COG0534	Mate efflux family protein
D0Y50_RS08530	COG0303	'Molybdopterin
D0Y50_RS08535	COG0366	Alpha amylase catalytic
D0Y50_RS08540	COG1215	transferase activity, transferring glycosyl groups
D0Y50_RS08545	COG3769	mannosylglycerate metabolic process
D0Y50_RS08550	COG0572	uridine kinase
D0Y50_RS08570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D0Y50_RS08575	COG0321	lipoyl(octanoyl) transferase activity
D0Y50_RS08580	COG2921	Belongs to the UPF0250 family
D0Y50_RS08585	COG1686	Belongs to the peptidase S11 family
D0Y50_RS08590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0Y50_RS08595	COG0772	Belongs to the SEDS family
D0Y50_RS08600	COG0768	penicillin binding
D0Y50_RS08605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D0Y50_RS08610	COG0799	negative regulation of ribosome biogenesis
D0Y50_RS08615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0Y50_RS08625	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D0Y50_RS08630	COG0495	leucyl-tRNA aminoacylation
D0Y50_RS08645	COG1067	ATP-dependent peptidase activity
D0Y50_RS08655	COG1534	Rna-binding protein
D0Y50_RS08660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D0Y50_RS08665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0Y50_RS08670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0Y50_RS08675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0Y50_RS08680	COG0149	triose-phosphate isomerase activity
D0Y50_RS08685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0Y50_RS08740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0Y50_RS08745	COG1597	lipid kinase activity
D0Y50_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS08775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Y50_RS08780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0Y50_RS08785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0Y50_RS08800	COG1185	polyribonucleotide nucleotidyltransferase activity
D0Y50_RS08810	COG0295	cytidine deaminase activity
D0Y50_RS08830	COG1196	nuclear chromosome segregation
D0Y50_RS08840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0Y50_RS08850	COG2333	competence protein COMEC
D0Y50_RS08850	COG0658	competence protein
D0Y50_RS08855	COG1132	(ABC) transporter
D0Y50_RS08860	COG1663	tetraacyldisaccharide 4'-kinase activity
D0Y50_RS08905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0Y50_RS08910	COG0435	Glutathione S-transferase
D0Y50_RS08935	COG0372	Belongs to the citrate synthase family
D0Y50_RS08940	COG2009	succinate dehydrogenase
D0Y50_RS08945	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0Y50_RS08950	COG1053	succinate dehydrogenase
D0Y50_RS08955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0Y50_RS08960	COG0567	Dehydrogenase, E1 component
D0Y50_RS08965	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Y50_RS09025	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D0Y50_RS09030	COG2986	histidine ammonia-lyase
D0Y50_RS09045	COG0366	Alpha amylase catalytic
D0Y50_RS09055	COG0366	Alpha amylase catalytic
D0Y50_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS09085	COG2267	carboxylic ester hydrolase activity
D0Y50_RS09090	COG0616	signal peptide processing
D0Y50_RS09105	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS09120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0Y50_RS09125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Y50_RS09130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0Y50_RS09135	COG0386	Belongs to the glutathione peroxidase family
D0Y50_RS09140	COG2084	Dehydrogenase
D0Y50_RS09155	COG1960	acyl-CoA dehydrogenase activity
D0Y50_RS09160	COG1024	Enoyl-CoA hydratase
D0Y50_RS09170	COG2226	methyltransferase
D0Y50_RS09175	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0Y50_RS09185	COG3082	Protein of unknown function (DUF1414)
D0Y50_RS09190	COG3081	Nucleoid-associated protein
D0Y50_RS09220	COG3275	phosphorelay sensor kinase activity
D0Y50_RS09225	COG3279	Response regulator of the LytR AlgR family
D0Y50_RS09230	COG0205	6-phosphofructokinase activity
D0Y50_RS09265	COG1054	Belongs to the UPF0176 family
D0Y50_RS09275	COG0513	Belongs to the DEAD box helicase family
D0Y50_RS09285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0Y50_RS09290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D0Y50_RS09295	COG0583	DNA-binding transcription factor activity
D0Y50_RS09315	COG1760	l-serine dehydratase
D0Y50_RS09335	COG1322	Protein conserved in bacteria
D0Y50_RS09345	COG1404	Belongs to the peptidase S8 family
D0Y50_RS09350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0Y50_RS09355	COG0022	dehydrogenase e1 component
D0Y50_RS09360	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Y50_RS09365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0Y50_RS09370	COG0515	serine threonine protein kinase
D0Y50_RS09375	COG1946	Acyl-CoA thioesterase
D0Y50_RS09380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0Y50_RS09395	COG2715	membrane protein required for spore maturation
D0Y50_RS09405	COG1956	GAF domain-containing protein
D0Y50_RS09420	COG0793	Belongs to the peptidase S41A family
D0Y50_RS09425	COG0733	neurotransmitter:sodium symporter activity
D0Y50_RS09430	COG1757	Na H antiporter
D0Y50_RS09435	COG0308	aminopeptidase N
D0Y50_RS09455	COG4447	cellulose binding
D0Y50_RS09465	COG2902	Dehydrogenase
D0Y50_RS09470	COG0167	dihydroorotate dehydrogenase activity
D0Y50_RS09485	COG0488	(ABC) transporter
D0Y50_RS09505	COG3130	regulation of translation
D0Y50_RS09510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0Y50_RS09520	COG0415	Belongs to the DNA photolyase family
D0Y50_RS09525	COG0415	Belongs to the DNA photolyase family
D0Y50_RS09530	COG3046	protein related to deoxyribodipyrimidine photolyase
D0Y50_RS09545	COG4644	lycopene metabolic process
D0Y50_RS09560	COG0531	amino acid
D0Y50_RS09580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0Y50_RS09590	COG2132	Multicopper oxidase
D0Y50_RS09620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0Y50_RS09635	COG1695	Transcriptional regulator
D0Y50_RS09640	COG2259	Doxx family
D0Y50_RS09685	COG1064	alcohol dehydrogenase
D0Y50_RS09710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0Y50_RS09715	COG0069	glutamate synthase activity
D0Y50_RS09735	COG2193	ferroxidase activity
D0Y50_RS09740	COG3278	Belongs to the heme-copper respiratory oxidase family
D0Y50_RS09755	COG2010	Cytochrome c
D0Y50_RS09780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Y50_RS09785	COG0589	response to stress
D0Y50_RS09795	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0Y50_RS09815	COG1280	lysine exporter protein (LysE YggA)
D0Y50_RS09820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0Y50_RS09825	COG2897	thiosulfate sulfurtransferase activity
D0Y50_RS09835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0Y50_RS09835	COG2755	lipolytic protein G-D-S-L family
D0Y50_RS09845	COG2801	Transposase and inactivated derivatives
D0Y50_RS09965	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS09970	COG2963	transposase activity
D0Y50_RS09990	COG3550	peptidyl-serine autophosphorylation
D0Y50_RS10000	COG2356	endonuclease I
D0Y50_RS10025	COG2059	Chromate
D0Y50_RS10140	COG0531	amino acid
D0Y50_RS10150	COG2132	Multicopper oxidase
D0Y50_RS10195	COG2963	transposase activity
D0Y50_RS10215	COG2801	Transposase and inactivated derivatives
D0Y50_RS10230	COG2217	Heavy metal translocating P-type atpase
D0Y50_RS10235	COG0789	Transcriptional regulator
D0Y50_RS10240	COG0309	Hydrogenase expression formation protein (HypE)
D0Y50_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS10330	COG2801	Transposase and inactivated derivatives
D0Y50_RS10370	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS10375	COG5002	protein histidine kinase activity
D0Y50_RS10385	COG2801	Transposase and inactivated derivatives
D0Y50_RS10465	COG3550	peptidyl-serine autophosphorylation
D0Y50_RS10495	COG2801	Transposase and inactivated derivatives
D0Y50_RS10545	COG3177	Filamentation induced by cAMP protein fic
D0Y50_RS10555	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS10590	COG0322	excinuclease ABC activity
D0Y50_RS10595	COG2197	response regulator
D0Y50_RS10600	COG4572	Cation transport regulator
D0Y50_RS10605	COG1741	Belongs to the pirin family
D0Y50_RS10610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Y50_RS10630	COG0670	Belongs to the BI1 family
D0Y50_RS10650	COG2920	part of a sulfur-relay system
D0Y50_RS10665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0Y50_RS10670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D0Y50_RS10675	COG0531	amino acid
D0Y50_RS10675	COG1674	ftsk spoiiie
D0Y50_RS10685	COG0686	Belongs to the AlaDH PNT family
D0Y50_RS10690	COG0284	orotidine-5'-phosphate decarboxylase activity
D0Y50_RS10695	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0Y50_RS10700	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D0Y50_RS10710	COG0776	regulation of translation
D0Y50_RS10715	COG0539	negative regulation of cytoplasmic translation
D0Y50_RS10720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0Y50_RS10725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0Y50_RS10745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Y50_RS10755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0Y50_RS10770	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D0Y50_RS10775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Y50_RS10785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0Y50_RS10795	COG4783	chaperone-mediated protein folding
D0Y50_RS10805	COG1393	Belongs to the ArsC family
D0Y50_RS10825	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D0Y50_RS10840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0Y50_RS10850	COG1960	acyl-CoA dehydrogenase activity
D0Y50_RS10860	COG3706	GGDEF domain
D0Y50_RS10875	COG0252	asparaginase activity
D0Y50_RS10895	COG3139	Protein of unknown function (DUF1315)
D0Y50_RS10905	COG1115	amino acid carrier protein
D0Y50_RS10910	COG2866	Carboxypeptidase
D0Y50_RS10935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0Y50_RS10945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0Y50_RS10950	COG1640	4-alpha-glucanotransferase
D0Y50_RS10955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0Y50_RS10960	COG0676	glucose-6-phosphate 1-epimerase activity
D0Y50_RS10965	COG0800	Aldolase
D0Y50_RS10975	COG0129	dihydroxy-acid dehydratase activity
D0Y50_RS10980	COG0363	glucosamine-6-phosphate deaminase activity
D0Y50_RS10985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0Y50_RS10990	COG1737	Transcriptional regulator
D0Y50_RS10995	COG0469	pyruvate kinase activity
D0Y50_RS11000	COG0778	Nitroreductase
D0Y50_RS11005	COG0616	signal peptide processing
D0Y50_RS11010	COG3091	SprT-like family
D0Y50_RS11015	COG3092	negative regulation of chromosome organization
D0Y50_RS11020	COG0492	ferredoxin-NADP+ reductase activity
D0Y50_RS11025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D0Y50_RS11030	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D0Y50_RS11035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0Y50_RS11040	COG0542	response to heat
D0Y50_RS11045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D0Y50_RS11050	COG1278	Cold shock
D0Y50_RS11065	COG0482	sulfurtransferase activity
D0Y50_RS11070	COG2915	High frequency lysogenization protein hflD homolog
D0Y50_RS11075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0Y50_RS11085	COG2850	peptidyl-arginine hydroxylation
D0Y50_RS11095	COG0277	FAD linked oxidase domain protein
D0Y50_RS11095	COG0247	lactate metabolic process
D0Y50_RS11105	COG1131	(ABC) transporter
D0Y50_RS11120	COG1045	serine acetyltransferase
D0Y50_RS11125	COG0438	transferase activity, transferring glycosyl groups
D0Y50_RS11130	COG1216	Glycosyl transferase, family 2
D0Y50_RS11130	COG1442	glycosyl transferase family 8
D0Y50_RS11165	COG0438	transferase activity, transferring glycosyl groups
D0Y50_RS11165	COG0297	glycogen (starch) synthase activity
D0Y50_RS11175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0Y50_RS11180	COG0574	Belongs to the PEP-utilizing enzyme family
D0Y50_RS11180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0Y50_RS11190	COG0457	Tetratricopeptide repeat
D0Y50_RS11195	COG4771	TonB-dependent receptor
D0Y50_RS11200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Y50_RS11210	COG2914	Belongs to the UPF0125 (RnfH) family
D0Y50_RS11215	COG2867	negative regulation of translational initiation
D0Y50_RS11240	COG3932	Exopolysaccharide synthesis, ExoD
D0Y50_RS11285	COG4989	oxidoreductase activity
D0Y50_RS11320	COG1309	transcriptional regulator
D0Y50_RS11350	COG3706	GGDEF domain
D0Y50_RS11355	COG4999	Histidine kinase
D0Y50_RS11355	COG2205	protein histidine kinase activity
D0Y50_RS11355	COG3850	Histidine kinase
D0Y50_RS11355	COG3437	response regulator, receiver
D0Y50_RS11365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0Y50_RS11365	COG3153	acetyltransferase
D0Y50_RS11390	COG0840	transmembrane signaling receptor activity
D0Y50_RS11405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D0Y50_RS11420	COG0195	Participates in both transcription termination and antitermination
D0Y50_RS11430	COG3437	response regulator, receiver
D0Y50_RS11435	COG2198	Histidine kinase
D0Y50_RS11435	COG0784	Response regulator, receiver
D0Y50_RS11435	COG2205	protein histidine kinase activity
D0Y50_RS11440	COG0028	Belongs to the TPP enzyme family
D0Y50_RS11465	COG0668	transmembrane transport
D0Y50_RS11490	COG1960	acyl-CoA dehydrogenase activity
D0Y50_RS11515	COG1960	acyl-CoA dehydrogenase activity
D0Y50_RS11525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0Y50_RS11530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D0Y50_RS11545	COG0314	molybdopterin synthase activity
D0Y50_RS11550	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D0Y50_RS11555	COG0315	cyclic pyranopterin monophosphate synthase activity
D0Y50_RS11560	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0Y50_RS11565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0Y50_RS11585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0Y50_RS11590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0Y50_RS11595	COG1074	ATP-dependent DNA helicase activity
D0Y50_RS11600	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D0Y50_RS11610	COG1022	Amp-dependent synthetase and ligase
D0Y50_RS11660	COG0583	DNA-binding transcription factor activity
D0Y50_RS11680	COG0640	Transcriptional regulator
D0Y50_RS11690	COG0583	DNA-binding transcription factor activity
D0Y50_RS11695	COG3300	MHYT domain
D0Y50_RS11695	COG5001	Diguanylate cyclase
D0Y50_RS11700	COG3932	Exopolysaccharide synthesis, ExoD
D0Y50_RS11705	COG2204	response regulator
D0Y50_RS11715	COG4251	negative regulation of phosphorylation
D0Y50_RS11720	COG0784	Response regulator, receiver
D0Y50_RS11725	COG5002	protein histidine kinase activity
D0Y50_RS11725	COG2198	Histidine kinase
D0Y50_RS11725	COG0784	Response regulator, receiver
D0Y50_RS11770	COG2853	Lipoprotein
D0Y50_RS11790	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS11800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0Y50_RS11805	COG2130	NADP-dependent
D0Y50_RS11810	COG3507	Belongs to the glycosyl hydrolase 43 family
D0Y50_RS11820	COG1501	Belongs to the glycosyl hydrolase 31 family
D0Y50_RS11825	COG1874	Beta-galactosidase
D0Y50_RS11855	COG1522	sequence-specific DNA binding
D0Y50_RS11885	COG1902	pentaerythritol trinitrate reductase activity
D0Y50_RS11890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0Y50_RS11905	COG1349	DNA-binding transcription factor activity
D0Y50_RS11930	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Y50_RS11970	COG2067	long-chain fatty acid transport protein
D0Y50_RS11985	COG1609	Transcriptional regulator
D0Y50_RS12020	COG1116	anion transmembrane transporter activity
D0Y50_RS12030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0Y50_RS12040	COG1648	precorrin-2 dehydrogenase activity
D0Y50_RS12040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0Y50_RS12045	COG0243	molybdopterin cofactor binding
D0Y50_RS12050	COG2146	nitrite reductase [NAD(P)H] activity
D0Y50_RS12055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0Y50_RS12060	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D0Y50_RS12065	COG0515	serine threonine protein kinase
D0Y50_RS12065	COG2815	serine threonine protein kinase
D0Y50_RS12070	COG2116	formate transmembrane transporter activity
D0Y50_RS12075	COG3707	response regulator
D0Y50_RS12080	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS12115	COG1187	pseudouridine synthase activity
D0Y50_RS12120	COG0840	transmembrane signaling receptor activity
D0Y50_RS12175	COG0489	protein tyrosine kinase activity
D0Y50_RS12180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Y50_RS12180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Y50_RS12190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Y50_RS12195	COG0741	lytic transglycosylase activity
D0Y50_RS12195	COG1388	LysM domain
D0Y50_RS12210	COG0215	cysteine-tRNA ligase activity
D0Y50_RS12215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0Y50_RS12220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Y50_RS12225	COG1785	Belongs to the alkaline phosphatase family
D0Y50_RS12230	COG1785	Belongs to the alkaline phosphatase family
D0Y50_RS12260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D0Y50_RS12265	COG1286	toxin biosynthetic process
D0Y50_RS12270	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D0Y50_RS12275	COG0285	dihydrofolate synthase activity
D0Y50_RS12305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0Y50_RS12310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Y50_RS12315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Y50_RS12320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Y50_RS12320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D0Y50_RS12350	COG3101	peptidyl-lysine hydroxylation
D0Y50_RS12360	COG0693	protein deglycase activity
D0Y50_RS12365	COG1902	pentaerythritol trinitrate reductase activity
D0Y50_RS12370	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y50_RS12370	COG1902	pentaerythritol trinitrate reductase activity
D0Y50_RS12395	COG2186	Transcriptional regulator
D0Y50_RS12405	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0Y50_RS12410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0Y50_RS12415	COG2983	Belongs to the UPF0260 family
D0Y50_RS12420	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0Y50_RS12425	COG2951	lytic endotransglycosylase activity
D0Y50_RS12435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D0Y50_RS12440	COG0318	PFAM AMP-dependent synthetase and ligase
D0Y50_RS12445	COG2267	carboxylic ester hydrolase activity
D0Y50_RS12465	COG1199	ATP-dependent helicase activity
D0Y50_RS12475	COG2212	antiporter activity
D0Y50_RS12495	COG1006	Multisubunit Na H antiporter MnhC subunit
D0Y50_RS12500	COG0651	ATP synthesis coupled electron transport
D0Y50_RS12505	COG0651	ATP synthesis coupled electron transport
D0Y50_RS12515	COG0651	ATP synthesis coupled electron transport
D0Y50_RS12565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0Y50_RS12570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Y50_RS12575	COG0131	Imidazoleglycerol-phosphate dehydratase
D0Y50_RS12575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0Y50_RS12580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0Y50_RS12600	COG0681	Belongs to the peptidase S26 family
D0Y50_RS12630	COG4771	TonB-dependent receptor
D0Y50_RS12655	COG0583	DNA-binding transcription factor activity
D0Y50_RS12670	COG0326	Molecular chaperone. Has ATPase activity
D0Y50_RS12675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0Y50_RS12695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0Y50_RS12705	COG3220	belongs to the UPF0276 family
D0Y50_RS12740	COG1183	phosphatidylcholine synthase activity
D0Y50_RS12750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Y50_RS12760	COG2801	Transposase and inactivated derivatives
D0Y50_RS12765	COG4584	PFAM Integrase catalytic
D0Y50_RS12815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y50_RS12835	COG2132	Multicopper oxidase
D0Y50_RS12860	COG1309	transcriptional regulator
D0Y50_RS12865	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS12885	COG2801	Transposase and inactivated derivatives
D0Y50_RS12905	COG0542	response to heat
D0Y50_RS12915	COG0564	pseudouridine synthase activity
D0Y50_RS12920	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y50_RS12930	COG1595	DNA-templated transcription, initiation
D0Y50_RS12945	COG4221	oxidoreductase activity
D0Y50_RS12960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Y50_RS12970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0Y50_RS12980	COG0142	geranyltranstransferase activity
D0Y50_RS12990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0Y50_RS13005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D0Y50_RS13020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Y50_RS13020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Y50_RS13035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Y50_RS13040	COG0488	(ABC) transporter
D0Y50_RS13050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D0Y50_RS13060	COG0560	Phosphoserine phosphatase
D0Y50_RS13075	COG0084	hydrolase, TatD family'
D0Y50_RS13085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0Y50_RS13110	COG3026	antisigma factor binding
D0Y50_RS13120	COG1595	DNA-templated transcription, initiation
D0Y50_RS13125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0Y50_RS13140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D0Y50_RS13150	COG1047	Peptidyl-prolyl cis-trans
D0Y50_RS13155	COG0347	Belongs to the P(II) protein family
D0Y50_RS13160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0Y50_RS13165	COG4969	Belongs to the N-Me-Phe pilin family
D0Y50_RS13220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0Y50_RS13225	COG1047	Peptidyl-prolyl cis-trans
D0Y50_RS13235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0Y50_RS13240	COG0196	riboflavin kinase activity
D0Y50_RS13245	COG0728	peptidoglycan biosynthetic process
D0Y50_RS13250	COG0268	Binds directly to 16S ribosomal RNA
D0Y50_RS13280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0Y50_RS13285	COG0776	regulation of translation
D0Y50_RS13290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0Y50_RS13295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0Y50_RS13300	COG0740	serine-type endopeptidase activity
D0Y50_RS13305	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0Y50_RS13360	COG1131	(ABC) transporter
D0Y50_RS13365	COG1720	tRNA m6t6A37 methyltransferase activity
D0Y50_RS13375	COG1234	tRNA 3'-trailer cleavage
D0Y50_RS13385	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0Y50_RS13395	COG0604	alcohol dehydrogenase
D0Y50_RS13450	COG1196	nuclear chromosome segregation
D0Y50_RS13450	COG3264	Mechanosensitive ion channel
D0Y50_RS13470	COG0516	GMP reductase activity
D0Y50_RS13470	COG0517	IMP dehydrogenase activity
D0Y50_RS13475	COG1570	exodeoxyribonuclease VII activity
D0Y50_RS13490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y50_RS13495	COG2976	Protein conserved in bacteria
D0Y50_RS13520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D0Y50_RS13530	COG2166	iron-sulfur cluster assembly
D0Y50_RS13545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0Y50_RS13550	COG0719	Fe-S assembly protein
D0Y50_RS13555	COG0396	ATPase activity
D0Y50_RS13560	COG0719	Fe-S assembly protein
D0Y50_RS13565	COG1104	cysteine desulfurase activity
D0Y50_RS13570	COG1959	2 iron, 2 sulfur cluster binding
D0Y50_RS13575	COG0840	transmembrane signaling receptor activity
D0Y50_RS13580	COG0840	transmembrane signaling receptor activity
D0Y50_RS13625	COG1045	serine acetyltransferase
D0Y50_RS13635	COG0483	inositol monophosphate 1-phosphatase activity
D0Y50_RS13640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0Y50_RS13645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0Y50_RS13650	COG1862	Preprotein translocase
D0Y50_RS13655	COG0343	queuine tRNA-ribosyltransferase activity
D0Y50_RS13670	COG3789	protein conserved in bacteria
D0Y50_RS13675	COG1842	Phage shock protein A
D0Y50_RS13695	COG5463	Belongs to the UPF0441 family
D0Y50_RS13700	COG0754	glutathionylspermidine amidase activity
D0Y50_RS13715	COG1785	Belongs to the alkaline phosphatase family
D0Y50_RS13730	COG2205	protein histidine kinase activity
D0Y50_RS13730	COG0784	Response regulator, receiver
D0Y50_RS13735	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS13770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D0Y50_RS13780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0Y50_RS13810	COG1215	transferase activity, transferring glycosyl groups
D0Y50_RS13840	COG1216	Glycosyl transferase, family 2
D0Y50_RS13855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Y50_RS13860	COG0438	transferase activity, transferring glycosyl groups
D0Y50_RS13875	COG0726	polysaccharide deacetylase
D0Y50_RS13880	COG1216	Glycosyl transferase, family 2
D0Y50_RS13890	COG1132	(ABC) transporter
D0Y50_RS13905	COG1216	Glycosyl transferase, family 2
D0Y50_RS13905	COG0463	Glycosyl transferase, family 2
D0Y50_RS13950	COG0726	polysaccharide deacetylase
D0Y50_RS13965	COG0489	protein tyrosine kinase activity
D0Y50_RS13980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0Y50_RS13990	COG3267	Type II secretory pathway component ExeA
D0Y50_RS13990	COG3409	Peptidoglycan-binding domain 1 protein
D0Y50_RS13995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0Y50_RS13995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D0Y50_RS14000	COG2827	Endonuclease containing a URI domain
D0Y50_RS14020	COG1560	Kdo2-lipid A biosynthetic process
D0Y50_RS14050	COG1960	acyl-CoA dehydrogenase activity
D0Y50_RS14060	COG1435	thymidine kinase activity
D0Y50_RS14080	COG1609	Transcriptional regulator
D0Y50_RS14085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0Y50_RS14120	COG0850	regulation of cytokinetic process
D0Y50_RS14125	COG1295	ribonuclease BN
D0Y50_RS14140	COG2205	protein histidine kinase activity
D0Y50_RS14140	COG0784	Response regulator, receiver
D0Y50_RS14155	COG4771	TonB-dependent receptor
D0Y50_RS14170	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS14175	COG4251	negative regulation of phosphorylation
D0Y50_RS14185	COG4251	negative regulation of phosphorylation
D0Y50_RS14190	COG1695	Transcriptional regulator
D0Y50_RS14215	COG3321	synthase
D0Y50_RS14215	COG0604	alcohol dehydrogenase
D0Y50_RS14220	COG0419	ATPase involved in DNA repair
D0Y50_RS14285	COG0513	Belongs to the DEAD box helicase family
D0Y50_RS14320	COG2031	fatty acid transporter
D0Y50_RS14325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Y50_RS14330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Y50_RS14335	COG0805	protein transport
D0Y50_RS14350	COG0861	Integral membrane protein TerC family
D0Y50_RS14365	COG1940	carbohydrate kinase activity
D0Y50_RS14365	COG1846	Transcriptional regulator
D0Y50_RS14385	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0Y50_RS14395	COG2855	membrane
D0Y50_RS14435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Y50_RS14440	COG0659	secondary active sulfate transmembrane transporter activity
D0Y50_RS14445	COG0589	response to stress
D0Y50_RS14465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0Y50_RS14465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0Y50_RS14480	COG0583	DNA-binding transcription factor activity
D0Y50_RS14490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Y50_RS14495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Y50_RS14500	COG0006	proline dipeptidase activity
D0Y50_RS14505	COG3079	Belongs to the UPF0149 family
D0Y50_RS14515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Y50_RS14525	COG0784	Response regulator, receiver
D0Y50_RS14525	COG5002	protein histidine kinase activity
D0Y50_RS14525	COG2198	Histidine kinase
D0Y50_RS14530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0Y50_RS14535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D0Y50_RS14540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Y50_RS14560	COG3313	Fe-S protein
D0Y50_RS14585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Y50_RS14590	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Y50_RS14595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0Y50_RS14610	COG3023	N-Acetylmuramoyl-L-alanine amidase
D0Y50_RS14615	COG3577	Aspartyl protease
D0Y50_RS14620	COG0157	Belongs to the NadC ModD family
D0Y50_RS14625	COG4969	Belongs to the N-Me-Phe pilin family
D0Y50_RS14630	COG1459	type II secretion system
D0Y50_RS14635	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D0Y50_RS14640	COG0237	dephospho-CoA kinase activity
D0Y50_RS14640	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D0Y50_RS14645	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D0Y50_RS14650	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D0Y50_RS14655	COG3608	succinylglutamate desuccinylase aspartoacylase
D0Y50_RS14660	COG0494	nUDIX hydrolase
D0Y50_RS14670	COG0739	heme binding
D0Y50_RS14675	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D0Y50_RS14680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0Y50_RS14685	COG0849	cell division
D0Y50_RS14690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0Y50_RS14695	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Y50_RS14700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0Y50_RS14710	COG0772	Belongs to the SEDS family
D0Y50_RS14715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0Y50_RS14725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0Y50_RS14735	COG0768	penicillin binding
D0Y50_RS14740	COG3116	cell division
D0Y50_RS14750	COG2001	Belongs to the MraZ family
D0Y50_RS14755	COG1119	ATPase activity
D0Y50_RS14790	COG2204	response regulator
D0Y50_RS14795	COG0643	Histidine kinase
D0Y50_RS14795	COG2198	Histidine kinase
D0Y50_RS14805	COG0501	Belongs to the peptidase M48B family
D0Y50_RS14810	COG0668	transmembrane transport
D0Y50_RS14815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0Y50_RS14820	COG0189	ligase activity
D0Y50_RS14825	COG1678	Uncharacterized ACR, COG1678
D0Y50_RS14830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0Y50_RS14855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0Y50_RS14860	COG0762	integral membrane protein
D0Y50_RS14870	COG0625	glutathione transferase activity
D0Y50_RS14895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0Y50_RS14905	COG0083	homoserine kinase activity
D0Y50_RS14915	COG0545	Peptidyl-prolyl cis-trans isomerase
D0Y50_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS14935	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D0Y50_RS14945	COG2205	protein histidine kinase activity
D0Y50_RS14970	COG1748	Saccharopine dehydrogenase
D0Y50_RS14985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D0Y50_RS14995	COG0792	nuclease activity
D0Y50_RS15010	COG2814	Major facilitator Superfamily
D0Y50_RS15020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0Y50_RS15025	COG0372	Belongs to the citrate synthase family
D0Y50_RS15030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0Y50_RS15035	COG2828	Protein conserved in bacteria
D0Y50_RS15050	COG0784	Response regulator, receiver
D0Y50_RS15050	COG5002	protein histidine kinase activity
D0Y50_RS15050	COG2198	Histidine kinase
D0Y50_RS15055	COG0067	glutamate synthase
D0Y50_RS15055	COG0069	glutamate synthase activity
D0Y50_RS15055	COG0070	glutamate synthase
D0Y50_RS15060	COG0493	'glutamate synthase
D0Y50_RS15075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0Y50_RS15080	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D0Y50_RS15085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0Y50_RS15090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0Y50_RS15100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0Y50_RS15105	COG0739	heme binding
D0Y50_RS15110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D0Y50_RS15125	COG4628	conserved protein (DUF2132)
D0Y50_RS15135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Y50_RS15140	COG0625	glutathione transferase activity
D0Y50_RS15160	COG1981	membrane
D0Y50_RS15175	COG1914	H( )-stimulated, divalent metal cation uptake system
D0Y50_RS15180	COG0436	Aminotransferase
D0Y50_RS15185	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS15190	COG1217	gtp-binding protein TYPA
D0Y50_RS15195	COG0174	glutamine synthetase
D0Y50_RS15205	COG3852	Histidine kinase
D0Y50_RS15210	COG2204	response regulator
D0Y50_RS15245	COG0583	DNA-binding transcription factor activity
D0Y50_RS15250	COG3437	response regulator, receiver
D0Y50_RS15275	COG2205	protein histidine kinase activity
D0Y50_RS15275	COG5002	protein histidine kinase activity
D0Y50_RS15275	COG0784	Response regulator, receiver
D0Y50_RS15285	COG0525	valine-tRNA ligase activity
D0Y50_RS15290	COG2927	DNA polymerase III (CHI subunit)
D0Y50_RS15295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0Y50_RS15300	COG0795	lipopolysaccharide-transporting ATPase activity
D0Y50_RS15305	COG0795	lipopolysaccharide-transporting ATPase activity
D0Y50_RS15315	COG4771	TonB-dependent receptor
D0Y50_RS15335	COG2207	Transcriptional regulator
D0Y50_RS15340	COG1073	alpha beta
D0Y50_RS15380	COG3250	beta-galactosidase activity
D0Y50_RS15385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Y50_RS15405	COG1309	transcriptional regulator
D0Y50_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS15450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0Y50_RS15465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0Y50_RS15495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0Y50_RS15495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0Y50_RS15500	COG1335	isochorismatase
D0Y50_RS15505	COG0628	permease
D0Y50_RS15515	COG0697	spore germination
D0Y50_RS15530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y50_RS15540	COG0395	ABC-type sugar transport system, permease component
D0Y50_RS15565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y50_RS15590	COG0243	molybdopterin cofactor binding
D0Y50_RS15595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0Y50_RS15600	COG0746	molybdenum cofactor guanylyltransferase activity
D0Y50_RS15630	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS15640	COG1960	acyl-CoA dehydrogenase activity
D0Y50_RS15650	COG0513	Belongs to the DEAD box helicase family
D0Y50_RS15655	COG1278	Cold shock
D0Y50_RS15680	COG5001	Diguanylate cyclase
D0Y50_RS15705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0Y50_RS15725	COG0109	protoheme IX farnesyltransferase activity
D0Y50_RS15745	COG0738	Major facilitator superfamily
D0Y50_RS15785	COG0583	DNA-binding transcription factor activity
D0Y50_RS15790	COG4206	TonB-dependent receptor
D0Y50_RS15795	COG0730	response to heat
D0Y50_RS15800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Y50_RS15815	COG2198	Histidine kinase
D0Y50_RS15815	COG0643	Histidine kinase
D0Y50_RS15835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D0Y50_RS15855	COG4191	Histidine kinase
D0Y50_RS15855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y50_RS15900	COG0417	DNA replication proofreading
D0Y50_RS15960	COG5001	Diguanylate cyclase
D0Y50_RS15960	COG1716	ATPase activity
D0Y50_RS15965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y50_RS15965	COG4191	Histidine kinase
D0Y50_RS15970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Y50_RS15980	COG1573	uracil-dna glycosylase
D0Y50_RS15985	COG3300	MHYT domain
D0Y50_RS15985	COG5001	Diguanylate cyclase
D0Y50_RS16005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0Y50_RS16035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Y50_RS16045	COG2124	cytochrome p450
D0Y50_RS16055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0Y50_RS16075	COG4206	TonB-dependent receptor
D0Y50_RS16090	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D0Y50_RS16095	COG0204	Acyl-transferase
D0Y50_RS16100	COG0204	Acyl-transferase
D0Y50_RS16105	COG0668	transmembrane transport
D0Y50_RS16125	COG0733	neurotransmitter:sodium symporter activity
D0Y50_RS16140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Y50_RS16155	COG0716	FMN binding
D0Y50_RS16165	COG0848	biopolymer transport protein
D0Y50_RS16175	COG0457	Tetratricopeptide repeat
D0Y50_RS16180	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D0Y50_RS16190	COG1215	transferase activity, transferring glycosyl groups
D0Y50_RS16205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D0Y50_RS16210	COG0702	epimerase
D0Y50_RS16230	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D0Y50_RS16250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0Y50_RS16270	COG1477	protein flavinylation
D0Y50_RS16275	COG2871	sodium ion transport
D0Y50_RS16280	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0Y50_RS16285	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0Y50_RS16290	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0Y50_RS16295	COG1805	sodium ion transport
D0Y50_RS16300	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0Y50_RS16305	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0Y50_RS16310	COG0545	Peptidyl-prolyl cis-trans isomerase
D0Y50_RS16315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0Y50_RS16330	COG0039	L-malate dehydrogenase activity
D0Y50_RS16335	COG1438	arginine binding
D0Y50_RS16360	COG0572	uridine kinase
D0Y50_RS16365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0Y50_RS16380	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D0Y50_RS16385	COG1192	Involved in chromosome partitioning
D0Y50_RS16390	COG1280	lysine exporter protein (LysE YggA)
D0Y50_RS16400	COG5001	Diguanylate cyclase
D0Y50_RS16400	COG4251	negative regulation of phosphorylation
D0Y50_RS16400	COG3706	GGDEF domain
D0Y50_RS16400	COG2203	Gaf domain
D0Y50_RS16425	COG0517	IMP dehydrogenase activity
D0Y50_RS16425	COG0516	GMP reductase activity
D0Y50_RS16430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Y50_RS16450	COG0189	ligase activity
D0Y50_RS16460	COG4067	protein conserved in archaea
D0Y50_RS16460	COG0189	ligase activity
D0Y50_RS16470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0Y50_RS16480	COG0667	Aldo Keto reductase
D0Y50_RS16550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D0Y50_RS16560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0Y50_RS16610	COG1216	Glycosyl transferase, family 2
D0Y50_RS16610	COG0438	transferase activity, transferring glycosyl groups
D0Y50_RS16620	COG0463	Glycosyl transferase, family 2
D0Y50_RS16625	COG0463	Glycosyl transferase, family 2
D0Y50_RS16640	COG2801	Transposase and inactivated derivatives
D0Y50_RS16645	COG1051	belongs to the nudix hydrolase family
D0Y50_RS16650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0Y50_RS16670	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D0Y50_RS16690	COG1215	transferase activity, transferring glycosyl groups
D0Y50_RS16705	COG0202	RNA polymerase activity
D0Y50_RS16725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0Y50_RS16730	COG0201	protein transport
D0Y50_RS16750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D0Y50_RS16785	COG3850	Histidine kinase
D0Y50_RS16785	COG2205	protein histidine kinase activity
D0Y50_RS16785	COG3437	response regulator, receiver
D0Y50_RS16785	COG4999	Histidine kinase
D0Y50_RS16800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Y50_RS16805	COG0557	exoribonuclease II activity
D0Y50_RS16810	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0Y50_RS16830	COG2234	aminopeptidase activity
D0Y50_RS16835	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS16865	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D0Y50_RS16870	COG0076	glutamate decarboxylase activity
D0Y50_RS16880	COG1271	oxidase subunit
D0Y50_RS16885	COG1294	oxidase, subunit
D0Y50_RS16895	COG1522	sequence-specific DNA binding
D0Y50_RS16915	COG1278	Cold shock
D0Y50_RS16940	COG0339	signal peptide processing
D0Y50_RS16945	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS16950	COG2204	response regulator
D0Y50_RS16960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Y50_RS16975	COG2801	Transposase and inactivated derivatives
D0Y50_RS17015	COG2801	Transposase and inactivated derivatives
D0Y50_RS17020	COG0642	Histidine kinase
D0Y50_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS17085	COG0463	Glycosyl transferase, family 2
D0Y50_RS17095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0Y50_RS17105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0Y50_RS17110	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS17115	COG2801	Transposase and inactivated derivatives
D0Y50_RS17125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0Y50_RS17175	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Y50_RS17185	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D0Y50_RS17195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0Y50_RS17210	COG0281	malic enzyme
D0Y50_RS17220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0Y50_RS17250	COG0456	acetyltransferase
D0Y50_RS17265	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0Y50_RS17270	COG2177	Part of the ABC transporter FtsEX involved in
D0Y50_RS17275	COG2884	Cell division ATP-binding protein ftsE
D0Y50_RS17280	COG0552	protein localization to endoplasmic reticulum
D0Y50_RS17285	COG0742	ribosomal rna small subunit methyltransferase
D0Y50_RS17290	COG3068	Protein conserved in bacteria
D0Y50_RS17295	COG2095	MarC family integral membrane protein
D0Y50_RS17315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0Y50_RS17320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0Y50_RS17330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0Y50_RS17340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D0Y50_RS17345	COG0076	glutamate decarboxylase activity
D0Y50_RS17350	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0Y50_RS17360	COG0842	Transport permease protein
D0Y50_RS17365	COG1131	(ABC) transporter
D0Y50_RS17370	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS17375	COG2205	protein histidine kinase activity
D0Y50_RS17380	COG1253	flavin adenine dinucleotide binding
D0Y50_RS17385	COG1966	Carbon starvation protein
D0Y50_RS17395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0Y50_RS17400	COG0049	tRNA binding
D0Y50_RS17405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D0Y50_RS17410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0Y50_RS17415	COG0085	RNA polymerase activity
D0Y50_RS17420	COG0222	ribosome binding
D0Y50_RS17425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0Y50_RS17430	COG0081	regulation of translation
D0Y50_RS17435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0Y50_RS17450	COG1178	ABC-type Fe3 transport system permease component
D0Y50_RS17455	COG3842	ATPase activity
D0Y50_RS17460	COG0250	Participates in transcription elongation, termination and antitermination
D0Y50_RS17465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0Y50_RS17475	COG1132	(ABC) transporter
D0Y50_RS17480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0Y50_RS17485	COG3590	peptidase
D0Y50_RS17495	COG0513	Belongs to the DEAD box helicase family
D0Y50_RS17515	COG3040	lipid binding
D0Y50_RS17525	COG0346	lactoylglutathione lyase activity
D0Y50_RS17545	COG0302	gtp cyclohydrolase
D0Y50_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS17570	COG1201	RNA secondary structure unwinding
D0Y50_RS17580	COG1793	dna ligase
D0Y50_RS17585	COG0625	glutathione transferase activity
D0Y50_RS17605	COG1012	belongs to the aldehyde dehydrogenase family
D0Y50_RS17610	COG0028	Belongs to the TPP enzyme family
D0Y50_RS17620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0Y50_RS17625	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0Y50_RS17630	COG0330	HflC and HflK could
D0Y50_RS17635	COG0330	HflC and HflK could
D0Y50_RS17640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0Y50_RS17650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0Y50_RS17655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D0Y50_RS17665	COG0802	atpase or kinase
D0Y50_RS17670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D0Y50_RS17670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0Y50_RS17695	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D0Y50_RS17700	COG0735	belongs to the Fur family
D0Y50_RS17720	COG0305	Participates in initiation and elongation during chromosome replication
D0Y50_RS17750	COG2258	MOSC domain
D0Y50_RS17790	COG1082	Xylose isomerase domain protein TIM barrel
D0Y50_RS17795	COG2211	Major facilitator Superfamily
D0Y50_RS17805	COG0673	inositol 2-dehydrogenase activity
D0Y50_RS17810	COG1609	Transcriptional regulator
D0Y50_RS17850	COG4771	TonB-dependent receptor
D0Y50_RS17865	COG0840	transmembrane signaling receptor activity
D0Y50_RS17890	COG0477	Major facilitator Superfamily
D0Y50_RS17905	COG1609	Transcriptional regulator
D0Y50_RS17905	COG2207	Transcriptional regulator
D0Y50_RS17910	COG1070	Carbohydrate kinase
D0Y50_RS17915	COG2115	Belongs to the xylose isomerase family
D0Y50_RS17925	COG3291	Pkd domain containing protein
D0Y50_RS17955	COG0667	Aldo Keto reductase
D0Y50_RS17965	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D0Y50_RS17975	COG0784	Response regulator, receiver
D0Y50_RS17995	COG4948	Mandelate Racemase Muconate Lactonizing
D0Y50_RS18000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0Y50_RS18005	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0Y50_RS18005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0Y50_RS18010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0Y50_RS18015	COG3661	Belongs to the glycosyl hydrolase 67 family
D0Y50_RS18025	COG1802	Transcriptional regulator
D0Y50_RS18035	COG1904	glucuronate isomerase
D0Y50_RS18040	COG0246	Mannitol dehydrogenase
D0Y50_RS18065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0Y50_RS18095	COG2801	Transposase and inactivated derivatives
D0Y50_RS18120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D0Y50_RS18130	COG0297	glycogen (starch) synthase activity
D0Y50_RS18135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y50_RS18135	COG4191	Histidine kinase
D0Y50_RS18140	COG0745	RESPONSE REGULATOR receiver
D0Y50_RS18145	COG0312	modulator of DNA gyrase
D0Y50_RS18150	COG3028	Belongs to the UPF0307 family
D0Y50_RS18155	COG0312	modulator of DNA gyrase
D0Y50_RS18160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0Y50_RS18165	COG3164	Protein of unknown function
D0Y50_RS18170	COG1530	ribonuclease E activity
D0Y50_RS18180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D0Y50_RS18185	COG1792	Involved in formation and maintenance of cell shape
D0Y50_RS18190	COG1077	Cell shape determining protein MreB Mrl
D0Y50_RS18210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0Y50_RS18210	COG2755	lipolytic protein G-D-S-L family
D0Y50_RS18215	COG2807	transmembrane transport
D0Y50_RS18220	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Y50_RS18250	COG0644	oxidoreductase
D0Y50_RS18255	COG1609	Transcriptional regulator
D0Y50_RS18260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Y50_RS18275	COG0629	single-stranded DNA binding
D0Y50_RS18290	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D0Y50_RS18295	COG1085	galactose-1-phosphate uridylyltransferase
D0Y50_RS18300	COG2017	converts alpha-aldose to the beta-anomer
D0Y50_RS18305	COG1609	Transcriptional regulator
D0Y50_RS18325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y50_RS18330	COG2814	Major facilitator Superfamily
D0Y50_RS18335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Y50_RS18350	COG4667	esterase of the alpha-beta hydrolase superfamily
D0Y50_RS18360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0Y50_RS18370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0Y50_RS18375	COG0163	prenyltransferase activity
D0Y50_RS18405	COG0019	diaminopimelate decarboxylase activity
D0Y50_RS18410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0Y50_RS18425	COG1011	Hydrolase
D0Y50_RS18435	COG3237	CsbD-like
D0Y50_RS18440	COG0210	DNA helicase
D0Y50_RS18450	COG2962	Rard protein
D0Y50_RS18455	COG2239	Acts as a magnesium transporter
D0Y50_RS18460	COG0514	ATP-dependent DNA helicase (RecQ)
D0Y50_RS18470	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D0Y50_RS18480	COG5001	Diguanylate cyclase
D0Y50_RS18480	COG5002	protein histidine kinase activity
D0Y50_RS18485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0Y50_RS18490	COG3064	Membrane
D0Y50_RS18505	COG3264	Mechanosensitive ion channel
D0Y50_RS18505	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D0Y50_RS18520	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0Y50_RS18525	COG0427	acetyl-CoA hydrolase
D0Y50_RS18530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Y50_RS18535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y50_RS18555	COG0753	catalase activity
D0Y50_RS18560	COG2199	diguanylate cyclase activity
D0Y50_RS18560	COG2200	EAL domain
D0Y50_RS18560	COG3287	FIST C domain
D0Y50_RS18585	COG1279	arginine transmembrane transporter activity
D0Y50_RS18600	COG2081	HI0933 family
D0Y50_RS18610	COG0678	peroxiredoxin activity
D0Y50_RS18610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0Y50_RS18620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0Y50_RS18625	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Y50_RS18635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Y50_RS18645	COG0194	GDP metabolic process
D0Y50_RS18655	COG0181	hydroxymethylbilane synthase activity
D0Y50_RS18665	COG2959	enzyme of heme biosynthesis
D0Y50_RS18695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0Y50_RS18705	COG2022	thiamine diphosphate biosynthetic process
D0Y50_RS18710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0Y50_RS18730	COG3106	COG3106 Predicted ATPase
D0Y50_RS18750	COG1609	Transcriptional regulator
D0Y50_RS18760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Y50_RS18765	COG1609	Transcriptional regulator
D0Y50_RS18770	COG3265	gluconokinase activity
D0Y50_RS18775	COG2610	gluconate transmembrane transporter activity
D0Y50_RS18790	COG1566	PFAM secretion protein HlyD family protein
D0Y50_RS18805	COG3279	Response regulator of the LytR AlgR family
D0Y50_RS18810	COG3275	phosphorelay sensor kinase activity
D0Y50_RS18840	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D0Y50_RS18845	COG0800	Aldolase
D0Y50_RS18850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Y50_RS18855	COG2271	Major facilitator Superfamily
D0Y50_RS18880	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y50_RS18910	COG0439	Biotin carboxylase
D0Y50_RS18925	COG1116	anion transmembrane transporter activity
D0Y50_RS18990	COG2826	transposase and inactivated derivatives, IS30 family
D0Y50_RS19045	COG0210	DNA helicase
D0Y50_RS19055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D0Y50_RS19060	COG3161	chorismate lyase activity
D0Y50_RS19075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0Y50_RS19085	COG0156	8-amino-7-oxononanoate synthase activity
D0Y50_RS19105	COG0859	PFAM glycosyl transferase family 9
D0Y50_RS19145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y50_RS19165	COG2003	Belongs to the UPF0758 family
D0Y50_RS19245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0Y50_RS19265	COG0009	L-threonylcarbamoyladenylate synthase
D0Y50_RS19270	COG0551	DNA topoisomerase type I activity
D0Y50_RS19280	COG0758	DNA mediated transformation
D0Y50_RS19285	COG1652	LysM domain
D0Y50_RS19295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0Y50_RS19300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0Y50_RS19300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0Y50_RS19305	COG0569	domain protein
D0Y50_RS19315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0Y50_RS19320	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D0Y50_RS19325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0Y50_RS19325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0Y50_RS19345	COG3078	GTPase activator activity
D0Y50_RS19355	COG2818	Glycosylase
D0Y50_RS19395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP