locus-tag class description HPG92_RS00095 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HPG92_RS00100 ENOG4107QR9 Iron-sulfur cluster binding protein HPG92_RS00105 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPG92_RS00145 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HPG92_RS00155 ENOG4105C2W permease HPG92_RS00160 ENOG4105BZ8 glutamate synthase HPG92_RS00165 ENOG4108R8B oxidoreductase Fe-S subunit HPG92_RS00170 ENOG4107UUR Chlorohydrolase aminohydrolase HPG92_RS00175 ENOG4105BZ8 glutamate synthase HPG92_RS00180 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HPG92_RS00185 ENOG4105C5B carbamate kinase HPG92_RS00195 ENOG4107S4Y M20 DapE family protein YgeY HPG92_RS00200 ENOG4107RCH Diaminopropionate ammonia-lyase HPG92_RS00205 ENOG4105IW6 Carbamoyltransferase HPG92_RS00210 ENOG4108JUB Transcriptional regulator HPG92_RS00295 ENOG41090KG Inner membrane protein YqjE HPG92_RS00305 ENOG4108JJA ABC, transporter HPG92_RS00310 ENOG4108MBX Secretion Protein HPG92_RS00520 ENOG4106JVB Replication Protein HPG92_RS00640 ENOG4108JJA ABC, transporter HPG92_RS00645 ENOG4108MBX Secretion Protein HPG92_RS00680 ENOG4105CN9 Peptidase m42 family protein HPG92_RS00710 ENOG4105D2N Aldolase HPG92_RS00735 ENOG4108UMN azlc family HPG92_RS00750 ENOG4105C0A alcohol dehydrogenase HPG92_RS00760 ENOG4105DKG l-rhamnose isomerase HPG92_RS00785 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG92_RS00795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPG92_RS00800 ENOG4108RPX mosc domain containing protein HPG92_RS00805 ENOG4105E0F Histidine kinase HPG92_RS00810 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPG92_RS00815 ENOG4105FMW periplasmic HPG92_RS00925 ENOG4105BZU Histidine kinase HPG92_RS00965 ENOG4105CTQ phosphohexokinase HPG92_RS00970 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HPG92_RS00985 ENOG4107QPK )-transporter HPG92_RS00995 ENOG4105EBK exported protein HPG92_RS01000 ENOG4108VTS Membrane HPG92_RS01005 ENOG4105DP0 ferredoxin-NADP reductase HPG92_RS01010 ENOG4105CBT Fructose-1,6-bisphosphatase HPG92_RS01020 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPG92_RS01035 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPG92_RS01050 ENOG41063M6 Cell Division Protein HPG92_RS01055 ENOG4105ETE Transcriptional regulator (LacI family HPG92_RS01060 ENOG4105C25 Primosomal protein n' HPG92_RS01070 ENOG4108QGT oligogalacturonate-specific porin HPG92_RS01075 ENOG4105CT4 transporter HPG92_RS01085 ENOG4105C28 cystathionine HPG92_RS01090 ENOG4105CFH Aspartokinase HPG92_RS01100 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HPG92_RS01105 ENOG4105SYT Methylenetetrahydrofolate reductase HPG92_RS01110 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HPG92_RS01115 ENOG4108XC3 NADH ubiquinone oxidoreductase HPG92_RS01120 ENOG4105DCT glycerol dehydrogenase HPG92_RS01130 ENOG4106R3P AraC family transcriptional regulator HPG92_RS01135 ENOG4105DIJ Phosphoethanolamine transferase HPG92_RS01165 ENOG4105C5Q Transcriptional regulator HPG92_RS01175 ENOG4105EJ2 Transcriptional regulator HPG92_RS01180 ENOG4108Y73 Membrane HPG92_RS01225 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HPG92_RS01260 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPG92_RS01265 ENOG4105PM1 preprotein translocase subunit SecE HPG92_RS01270 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPG92_RS01285 ENOG4108VZM 50s ribosomal protein L10 HPG92_RS01290 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HPG92_RS01295 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPG92_RS01300 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPG92_RS01315 ENOG4105VCP PTS System HPG92_RS01325 ENOG4105D41 biosynthesis protein thiH HPG92_RS01335 ENOG4105WHD thiamine biosynthesis protein ThiS HPG92_RS01340 ENOG4105D06 uba thif-type nad fad binding protein HPG92_RS01355 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HPG92_RS01370 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HPG92_RS01375 ENOG4105R2J Conserved Protein HPG92_RS01380 ENOG4105K70 DNA-binding protein HPG92_RS01385 ENOG4108T8B Protein of unknown function (DUF1481) HPG92_RS01395 ENOG4105BZU Histidine kinase HPG92_RS01400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPG92_RS01405 ENOG4105C12 Phosphoribosylglycinamide synthetase HPG92_RS01440 ENOG4105K5X acetyltransferase HPG92_RS01450 ENOG4107QP3 malate synthase g HPG92_RS01455 ENOG4108I9X Isocitrate lyase HPG92_RS01470 ENOG41069M3 Transcriptional regulator HPG92_RS01480 ENOG4105C3R Methionine synthase HPG92_RS01485 ENOG4105EAM Na Pi-cotransporter HPG92_RS01500 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HPG92_RS01505 ENOG4105FE9 pseudouridine synthase HPG92_RS01510 ENOG4108ZR5 Conserved Protein HPG92_RS01515 ENOG4105CFH Aspartokinase HPG92_RS01530 ENOG4108MDC (LipO)protein HPG92_RS01535 ENOG4108Q9C Periplasmic Protein HPG92_RS01540 ENOG4105E3R (LipO)protein HPG92_RS01545 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HPG92_RS01550 ENOG4107QNK )-transporter HPG92_RS01555 ENOG4105EG2 ABC transporter, permease HPG92_RS01560 ENOG4105D56 permease protein HPG92_RS01565 ENOG4107FKK extracellular solute-binding protein family 1 HPG92_RS01570 ENOG4108IJ9 (ABC) transporter HPG92_RS01580 ENOG4107W52 maltose operon periplasmic protein HPG92_RS01600 ENOG41080IJ Diacylglycerol kinase HPG92_RS01605 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HPG92_RS01610 ENOG4107R73 Mate efflux family protein HPG92_RS01620 ENOG4105VDW Csbd family HPG92_RS01625 ENOG4105MYN Zinc uptake regulation protein HPG92_RS01635 ENOG4105E2A Dehydrogenase HPG92_RS01640 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPG92_RS01645 ENOG4105P4Z Phage shock protein G HPG92_RS01650 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPG92_RS01655 ENOG4105CDU Replicative dna helicase HPG92_RS01660 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPG92_RS01665 ENOG4105CGF Aromatic amino acid aminotransferase HPG92_RS01670 ENOG4105F0S class B acid phosphatase HPG92_RS01675 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HPG92_RS01680 ENOG4105MSB protein, conserved in bacteria HPG92_RS01695 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPG92_RS01700 ENOG4108UUM single-stranded DNA-binding protein HPG92_RS01735 ENOG4105PMV Membrane HPG92_RS01740 ENOG4108M8H domain protein HPG92_RS01745 ENOG4108W3Q Transcriptional regulator HPG92_RS01750 ENOG4108Z4X TRANSCRIPTIONal HPG92_RS01760 ENOG4105C7N Xanthine uracil vitamin C permease HPG92_RS01765 ENOG4105EEQ Na H antiporter HPG92_RS01770 ENOG4105CMU LysR family (Transcriptional regulator HPG92_RS01780 ENOG41067MG lrgb family HPG92_RS01785 ENOG4107QN1 sodium solute HPG92_RS01790 ENOG41062QD Membrane HPG92_RS01795 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPG92_RS01805 ENOG4105CK2 sodium dicarboxylate symporter HPG92_RS01810 ENOG41082ND Uncharacterized protein yjcO HPG92_RS01820 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPG92_RS01825 ENOG4108MI0 Resistance protein HPG92_RS01830 ENOG4105J12 Multidrug resistance protein mdtN HPG92_RS01840 ENOG4105EUZ Beta-lactamase domain protein HPG92_RS01850 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HPG92_RS01855 ENOG4105CSH Transporter HPG92_RS01865 ENOG4105ECM Sensor protein basS pmrB HPG92_RS01870 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPG92_RS01875 ENOG4105DIJ Phosphoethanolamine transferase HPG92_RS01880 ENOG4105D5Q Arginine ornithine antiporter HPG92_RS01885 ENOG4106ZGR Transcriptional regulator HPG92_RS01895 ENOG4108K2B transcriptional regulator HPG92_RS01900 ENOG4105F8D glycoside hydrolase family 4 HPG92_RS01905 ENOG4105CT4 transporter HPG92_RS01910 ENOG4107GFK fumarate HPG92_RS01915 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPG92_RS01925 ENOG4108MRH transcriptional regulatory protein HPG92_RS01930 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPG92_RS01935 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HPG92_RS01940 ENOG4105EHG Permease protein HPG92_RS01945 ENOG4107R4I Periplasmic binding protein HPG92_RS01950 ENOG4106QJH hemin transport protein HPG92_RS01955 ENOG4107ENK receptor HPG92_RS01975 ENOG4108ZK4 sdia-regulated domain-containing protein HPG92_RS01980 ENOG41068CG regulatoR HPG92_RS02010 ENOG4108SIC Transcriptional regulator HPG92_RS02025 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPG92_RS02030 ENOG4108IJ0 Aspartate ammonia-lyase HPG92_RS02040 ENOG4105DVH amino acid HPG92_RS02055 ENOG4108ZVF (LipO)protein HPG92_RS02060 ENOG4105MTB Uncharacterized protein YjeJ HPG92_RS02065 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPG92_RS02070 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HPG92_RS02080 ENOG4106BSU Entericidin B HPG92_RS02090 ENOG4105KPY Small multidrug resistance protein HPG92_RS02100 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HPG92_RS02110 ENOG4105E33 succinate dehydrogenase HPG92_RS02115 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HPG92_RS02125 ENOG4107SC7 Inner membrane transporter yjeM HPG92_RS02130 ENOG4105H38 Membrane HPG92_RS02150 ENOG4105H8W Fimbrial protein HPG92_RS02160 ENOG4108TTM chaperone HPG92_RS02175 ENOG4105EGS Mechanosensitive ion channel HPG92_RS02190 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HPG92_RS02195 ENOG4106TNF Periplasmic binding protein HPG92_RS02215 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HPG92_RS02220 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HPG92_RS02225 ENOG4105K8N protein family UPF0079, ATPase HPG92_RS02230 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPG92_RS02245 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HPG92_RS02250 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPG92_RS02255 ENOG4107QJR hflk protein HPG92_RS02260 ENOG4105EPW hflc protein HPG92_RS02285 ENOG4105DJY efflux transporter, rnd family, mfp subunit HPG92_RS02290 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPG92_RS02315 ENOG4105CHR reductase HPG92_RS02325 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HPG92_RS02335 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPG92_RS02340 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPG92_RS02345 ENOG4108P9J Phage shock protein A HPG92_RS02350 ENOG4108P9J Phage shock protein A HPG92_RS02365 ENOG4105CSU acyl-Coa dehydrogenase HPG92_RS02370 ENOG4105S17 UPF0379 protein yjfN HPG92_RS02375 ENOG4105WSB biofilm stress and motility protein A HPG92_RS02380 ENOG4108MXZ Esterase HPG92_RS02395 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HPG92_RS02405 ENOG4106ETB IIa component HPG92_RS02425 ENOG4105KIT UPF0379 protein yjfY HPG92_RS02435 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HPG92_RS02440 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HPG92_RS02445 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HPG92_RS02450 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HPG92_RS02460 ENOG4105FHY Opacity-associated protein A HPG92_RS02465 ENOG4108V1T peptidylprolyl cis-trans isomerase HPG92_RS02480 ENOG4105DXC membrane HPG92_RS02485 ENOG4105ECR NmrA family HPG92_RS02490 ENOG4105KVH Transcriptional regulator HPG92_RS02495 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HPG92_RS02500 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HPG92_RS02505 ENOG4108UUE Transcriptional regulator HPG92_RS02510 ENOG41061GZ Protein of unknown function (DUF1107) HPG92_RS02515 ENOG4105C37 (CBS) domain HPG92_RS02520 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPG92_RS02535 ENOG4108ZHD aig2 family HPG92_RS02540 ENOG4105F0N pyrophosphate phospho-hydrolase HPG92_RS02545 ENOG4105C8Q Methyl-accepting chemotaxis HPG92_RS02555 ENOG4105DFU Cell wall formation (By similarity) HPG92_RS02560 ENOG4105N42 UPF0307 protein HPG92_RS02565 ENOG4105CMS peptidase U62, modulator of DNA gyrase HPG92_RS02570 ENOG4108XVM Cytochrome b(562) HPG92_RS02600 ENOG41069H0 dihydroorotase EC 3.5.2.3 HPG92_RS02615 ENOG4105EMD TRANSCRIPTIONal HPG92_RS02625 ENOG4105K4U addiction module toxin, RelE StbE family HPG92_RS02630 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HPG92_RS02635 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HPG92_RS02640 ENOG4105CG3 alpha amylase, catalytic region HPG92_RS02645 ENOG4105C5Y PTS System HPG92_RS02650 ENOG4105D4X repressor HPG92_RS02665 ENOG4105KME endoribonuclease L-psp HPG92_RS02680 ENOG41077AM PyrBI operon attenuator HPG92_RS02690 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HPG92_RS02695 ENOG4105CSX c4-dicarboxylate anaerobic carrier HPG92_RS02700 ENOG4105DBV ornithine carbamoyltransferase HPG92_RS02710 ENOG4105CEU Arginine dihydrolase HPG92_RS02715 ENOG4105XEP YhcH YjgK YiaL family protein HPG92_RS02720 ENOG4105DBV ornithine carbamoyltransferase HPG92_RS02725 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HPG92_RS02730 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HPG92_RS02735 ENOG4108MJ3 acetyltransferase HPG92_RS02740 ENOG4108M3P Membrane HPG92_RS02745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPG92_RS02750 ENOG4105MYG DNA polymerase iii, chi subunit HPG92_RS02760 ENOG4108M8S permease YjgP YjgQ family protein HPG92_RS02765 ENOG4108K5H permease YjgP YjgQ family protein HPG92_RS02785 ENOG4105DQ4 alcohol dehydrogenase HPG92_RS02820 ENOG4107R3N Filamentation induced by cAMP protein fic HPG92_RS02880 ENOG4108W9T type 1 fimbriae regulatory protein HPG92_RS02885 ENOG4105MX3 Fimbrial HPG92_RS02890 ENOG4108VCD Chaperone HPG92_RS02895 ENOG4105CW0 outer membrane usher protein HPG92_RS02920 ENOG4105DZY Pts system, glucitol sorbitol-specific HPG92_RS02930 ENOG410787A Pts system, glucitol sorbitol-specific HPG92_RS03075 ENOG4105DTA methyltransferase HPG92_RS03085 ENOG4105KZM cytoplasmic protein HPG92_RS03095 ENOG4106AM8 polysaccharide lyase family 8 HPG92_RS03120 ENOG4105F3R pts system mannose fructose sorbose family iid HPG92_RS03125 ENOG4105ETZ PTS System HPG92_RS03130 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HPG92_RS03150 ENOG4105C6F GntR Family Transcriptional Regulator HPG92_RS03175 ENOG4105DYB Isoaspartyl dipeptidase HPG92_RS03180 ENOG4108P2H Inner membrane protein YjiG HPG92_RS03185 ENOG41074DU domain protein HPG92_RS03190 ENOG4105CBP Major Facilitator HPG92_RS03195 ENOG4106BRA Membrane HPG92_RS03200 ENOG41083G8 Multidrug resistance protein MdtM HPG92_RS03210 ENOG4105C26 Dehydrogenase HPG92_RS03230 ENOG4107QTH restriction modification system DNA specificity domain HPG92_RS03240 ENOG4108F3G Type I restriction-modification system, R subunit HPG92_RS03245 ENOG4106H3A restriction HPG92_RS03260 ENOG4105CKI cobalamin synthesis protein HPG92_RS03265 ENOG4105VCD cytoplasmic protein HPG92_RS03270 ENOG4105D22 carbon starvation protein HPG92_RS03275 ENOG4105C8Q Methyl-accepting chemotaxis HPG92_RS03295 ENOG4108IQ3 PTS system HPG92_RS03300 ENOG4105ETZ PTS System HPG92_RS03305 ENOG4105F3R pts system mannose fructose sorbose family iid HPG92_RS03310 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HPG92_RS03315 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HPG92_RS03325 ENOG4105RI1 glycoprotein receptor HPG92_RS03330 ENOG4106CVF DNA replication protein HPG92_RS03345 ENOG4105DWK Membrane HPG92_RS03350 ENOG4108N8T regulatoR HPG92_RS03355 ENOG4108T94 DNA-binding transcriptional activator BglJ HPG92_RS03360 ENOG4108UIN ybak prolyl-trna synthetase associated region HPG92_RS03365 ENOG4108819 ferric iron reductase HPG92_RS03370 ENOG4105BZU Histidine kinase HPG92_RS03375 ENOG4105YBH Protein of unknown function (DUF1435) HPG92_RS03400 ENOG4108WPU DNA polymerase III subunit psi HPG92_RS03405 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HPG92_RS03410 ENOG4105PAD Hydrolase HPG92_RS03420 ENOG4105K3G Periplasmic Protein HPG92_RS03430 ENOG4108NRW Phospholipase, patatin family HPG92_RS03435 ENOG4105EYA deoxyribonuclease HPG92_RS03440 ENOG41076CZ activating enzyme HPG92_RS03445 ENOG4105G0K glycine radical enzyme YjjI family HPG92_RS03470 ENOG4108UK5 Transposase HPG92_RS03480 ENOG41062Z9 Membrane HPG92_RS03485 ENOG4105EAC phosphoserine phosphatase HPG92_RS03490 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPG92_RS03495 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HPG92_RS03500 ENOG4105C5H ABC transporter HPG92_RS03505 ENOG4107SC1 transglycosylase HPG92_RS03515 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPG92_RS03525 ENOG4105UEI Transcriptional Regulator AraC Family HPG92_RS03530 ENOG4108RH0 Crea protein HPG92_RS03545 ENOG4105CW0 outer membrane usher protein HPG92_RS03550 ENOG4108VCD Chaperone HPG92_RS03560 ENOG4108PNB DNA-binding transcriptional regulator HPG92_RS03570 ENOG41065U4 response regulator HPG92_RS03580 ENOG4106FVC RNA methyltransferase HPG92_RS03590 ENOG4105CFH Aspartokinase HPG92_RS03595 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HPG92_RS03600 ENOG4105D98 threonine synthase HPG92_RS03610 ENOG4105BZG amino acid carrier protein HPG92_RS03615 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPG92_RS03620 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPG92_RS03625 ENOG4106HK8 GPR1 FUN34 yaaH family protein HPG92_RS03630 ENOG4108QUJ UPF0174 protein YaaW HPG92_RS03680 ENOG4105CGH 5'-nucleotidase HPG92_RS03690 ENOG41061MV Arylsulfatase HPG92_RS03695 ENOG4105C4X radical SAM domain protein HPG92_RS03715 ENOG41063Z6 transcriptional regulator, lysR family HPG92_RS03730 ENOG4105DTN riboflavin biosynthesis protein ribF HPG92_RS03745 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HPG92_RS03780 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPG92_RS03785 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPG92_RS03790 ENOG4108XNW Transcriptional activatory protein CaiF HPG92_RS03835 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPG92_RS03840 ENOG4105WQV ferredoxin-like protein HPG92_RS03845 ENOG4105C54 Major Facilitator superfamily HPG92_RS03850 ENOG4105M5B (LipO)protein HPG92_RS03890 ENOG4105NWN ApaG protein HPG92_RS03900 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HPG92_RS03910 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HPG92_RS03920 ENOG4105D3G Pseudouridine synthase HPG92_RS03930 ENOG4105CQ2 DNA polymerase HPG92_RS03940 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPG92_RS03955 ENOG41063TF transcriptional regulator (AraC HPG92_RS03970 ENOG4108KF1 Membrane HPG92_RS03975 ENOG4107T0D ABC, transporter HPG92_RS04000 ENOG4105S8Q sugar efflux transporter HPG92_RS04005 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HPG92_RS04020 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HPG92_RS04030 ENOG41064T2 transcriptional regulator, lysR family HPG92_RS04035 ENOG4105C7K acetolactate synthase HPG92_RS04040 ENOG4108ZP8 Acetolactate synthase small subunit HPG92_RS04045 ENOG4107B7Y DNA-binding transcriptional regulator FruR HPG92_RS04060 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HPG92_RS04065 ENOG4105CJN penicillin-binding protein HPG92_RS04075 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HPG92_RS04080 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HPG92_RS04090 ENOG4105CNI cell division protein FtsW HPG92_RS04110 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HPG92_RS04115 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPG92_RS04120 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPG92_RS04145 ENOG4105M6F mutator MutT protein HPG92_RS04160 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HPG92_RS04165 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPG92_RS04175 ENOG4105D7Q type ii secretion system HPG92_RS04180 ENOG4107QHF type ii secretion system protein e HPG92_RS04185 ENOG4108ZUW Major pilin subunit HPG92_RS04190 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPG92_RS04200 ENOG4106A72 regulatory protein AmpE HPG92_RS04205 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HPG92_RS04210 ENOG4105CT4 transporter HPG92_RS04225 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPG92_RS04230 ENOG4107QSN dihydrolipoamide acetyltransferase HPG92_RS04235 ENOG4107QN2 dihydrolipoyl dehydrogenase HPG92_RS04250 ENOG4108NST exported protein HPG92_RS04255 ENOG4107QIJ Aconitate hydratase 2 HPG92_RS04265 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HPG92_RS04270 ENOG4107S2N Type III effector Hrp-dependent HPG92_RS04275 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HPG92_RS04280 ENOG4105MVE transcriptional regulator HPG92_RS04295 ENOG4108ZRK uncharacterized protein yacC HPG92_RS04300 ENOG4105E3B Multicopper oxidase HPG92_RS04305 ENOG4105DZG Dehydrogenase HPG92_RS04310 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPG92_RS04315 ENOG41077A9 carbonic anhydrase HPG92_RS04320 ENOG4105DA5 (ABC) transporter HPG92_RS04325 ENOG4105E3A (ABC) transporter HPG92_RS04330 ENOG4108YTN IIa component HPG92_RS04335 ENOG4107BJW polysaccharide deacetylase HPG92_RS04355 ENOG4108XEY fimbrial-like adhesin protein HPG92_RS04360 ENOG4105CW0 outer membrane usher protein HPG92_RS04365 ENOG4108VEV chaperone HPG92_RS04390 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPG92_RS04395 ENOG4105DJ0 Poly(A) Polymerase HPG92_RS04400 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HPG92_RS04405 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HPG92_RS04410 ENOG4105PW4 Sugar fermentation stimulation protein homolog HPG92_RS04415 ENOG4107XID 2'-5' rna ligase HPG92_RS04420 ENOG4105CQ7 ATP-dependent helicase HPG92_RS04425 ENOG4105BZ4 penicillin-binding protein HPG92_RS04430 ENOG4105E0K tonB-dependent siderophore receptor HPG92_RS04435 ENOG4105E0A ABC, transporter HPG92_RS04440 ENOG4105J76 Periplasmic binding protein HPG92_RS04445 ENOG4105S6R Iron-hydroxamate transporter permease subunit HPG92_RS04460 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HPG92_RS04465 ENOG4105EN6 Membrane HPG92_RS04470 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HPG92_RS04485 ENOG4105C0H protease HPG92_RS04500 ENOG4105CSH Transporter HPG92_RS04505 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HPG92_RS04515 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPG92_RS04520 ENOG4105CE9 30S ribosomal protein S2 HPG92_RS04530 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HPG92_RS04535 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HPG92_RS04550 ENOG4105KNE Phosphatidate cytidylyltransferase HPG92_RS04560 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPG92_RS04565 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HPG92_RS04570 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPG92_RS04575 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HPG92_RS04580 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPG92_RS04595 ENOG4105C0B DNA polymerase III (alpha subunit) HPG92_RS04600 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HPG92_RS04605 ENOG4108M1A Chitin-binding protein HPG92_RS04610 ENOG4105CXN decarboxylase HPG92_RS04615 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HPG92_RS04625 ENOG4105M1T rho-binding antiterminator HPG92_RS04635 ENOG4108VWS Yaeq family HPG92_RS04640 ENOG4108YZN class I peptide chain release factor HPG92_RS04645 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HPG92_RS04655 ENOG4108R96 Methyltransferase, YaeB family HPG92_RS04660 ENOG4108R8X outer membrane lipoprotein HPG92_RS04665 ENOG4105D01 (LipO)protein HPG92_RS04670 ENOG4108UMI ABC transporter, permease HPG92_RS04680 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPG92_RS04715 ENOG4105CV8 reductase HPG92_RS04720 ENOG4105HEI LysR family (Transcriptional regulator HPG92_RS04725 ENOG4105F27 Major Facilitator HPG92_RS04740 ENOG4105E9H Lytic Murein transglycosylase HPG92_RS04750 ENOG4105D1A Methyltransferase HPG92_RS04755 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPG92_RS04760 ENOG4107RZZ dna polymerase iii epsilon subunit HPG92_RS04770 ENOG4105T40 surface antigen msp4 family protein HPG92_RS04785 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPG92_RS04790 ENOG4107QPN acyl-Coa dehydrogenase HPG92_RS04800 ENOG4105E7A Glutamine amidotransferase HPG92_RS04805 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HPG92_RS04815 ENOG4105CIN aminoacyl-histidine dipeptidase HPG92_RS04820 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HPG92_RS04835 ENOG4105FCK Membrane HPG92_RS04860 ENOG4105UZW Tail fiber assembly protein HPG92_RS04880 ENOG4107QUY Guanine deaminase HPG92_RS04885 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPG92_RS04895 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPG92_RS04915 ENOG4105JHE Major Facilitator Superfamily HPG92_RS04920 ENOG4107QMH DNA methylase HPG92_RS04925 ENOG4105D8D Type III HPG92_RS04935 ENOG4105C4M (Ubiquinol oxidase) subunit I HPG92_RS04940 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPG92_RS04960 ENOG4105E82 cytochrome subunit of dehydrogenase HPG92_RS04965 ENOG4105TDT uncharacterized protein yahO HPG92_RS04970 ENOG4108JU7 Transcriptional regulator HPG92_RS04975 ENOG4105CR4 methylisocitrate lyase HPG92_RS04980 ENOG4105BZN citrate synthase HPG92_RS04985 ENOG4105DXD 2-methylcitrate dehydratase HPG92_RS04990 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPG92_RS04995 ENOG4105D52 delta-aminolevulinic acid dehydratase HPG92_RS05000 ENOG4108NSE outer membrane autotransporter barrel HPG92_RS05005 ENOG4108PNB DNA-binding transcriptional regulator HPG92_RS05010 ENOG4107R6D beta-lactam binding protein AmpH HPG92_RS05015 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HPG92_RS05020 ENOG4107QS8 (LipO)protein HPG92_RS05025 ENOG4105FR5 inner membrane protein YaiY HPG92_RS05030 ENOG4105UNH Membrane HPG92_RS05035 ENOG4105CPF Cell wall formation (By similarity) HPG92_RS05050 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) HPG92_RS05055 ENOG4105VIF phosphate starvation-inducible protein HPG92_RS05060 ENOG4105BZU Histidine kinase HPG92_RS05065 ENOG4105II7 pyrroline-5-carboxylate reductase HPG92_RS05070 ENOG4108UPT UPF0178 protein HPG92_RS05080 ENOG4105SS3 HPG92_RS05085 ENOG4105HBA AroM protein HPG92_RS05100 ENOG4105DKQ ROK family HPG92_RS05105 ENOG4105F27 Major Facilitator HPG92_RS05110 ENOG4105EYH Exonuclease HPG92_RS05115 ENOG4107RH8 nuclease SbcCD subunit D HPG92_RS05120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG92_RS05125 ENOG4105BZU Histidine kinase HPG92_RS05130 ENOG4105CWM branched-chain amino acid transport system II carrier protein HPG92_RS05135 ENOG4105C85 amino acid HPG92_RS05140 ENOG4107R28 alpha amylase, catalytic region HPG92_RS05150 ENOG4105D3R alkyl hydroperoxide reductase HPG92_RS05160 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HPG92_RS05170 ENOG4105VIE preprotein translocase, subunit YajC HPG92_RS05180 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPG92_RS05185 ENOG4105N1F Hnh endonuclease HPG92_RS05195 ENOG4105DRB nucleoside-specific channel-forming protein HPG92_RS05200 ENOG4108KIC (LipO)protein HPG92_RS05210 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPG92_RS05220 ENOG4107YIM Involved in the transcription termination process (By similarity) HPG92_RS05225 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HPG92_RS05230 ENOG4108ZAI phosphatidylglycerophosphatase a HPG92_RS05235 ENOG4105CPC Aldo Keto reductase HPG92_RS05245 ENOG4105CTB Polyprenyl synthetase HPG92_RS05250 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPG92_RS05260 ENOG4107S0N DJ-1 family HPG92_RS05265 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPG92_RS05275 ENOG4107RDB Major Facilitator HPG92_RS05285 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HPG92_RS05290 ENOG4105CCU oxidase (Subunit III) HPG92_RS05295 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPG92_RS05300 ENOG4105E2S oxidase) subunit II HPG92_RS05305 ENOG4105EYM Major Facilitator superfamily HPG92_RS05310 ENOG4105IEY (LipO)protein HPG92_RS05315 ENOG4105M85 Bola protein HPG92_RS05330 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HPG92_RS05340 ENOG4105K70 DNA-binding protein HPG92_RS05345 ENOG4105EIN peptidylprolyl cis-trans isomerase HPG92_RS05350 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HPG92_RS05355 ENOG4108TGP Thioesterase superfamily protein HPG92_RS05365 ENOG4108NFA extracellular solute-binding protein HPG92_RS05370 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HPG92_RS05375 ENOG4108RS6 transposase HPG92_RS05385 ENOG4108XM1 transcriptional regulator AsnC family HPG92_RS05390 ENOG4105BZ1 (ABC) transporter HPG92_RS05395 ENOG4105BZ1 (ABC) transporter HPG92_RS05400 ENOG4108YZA Nitrogen regulatory protein pii HPG92_RS05405 ENOG4105BZU Histidine kinase HPG92_RS05410 ENOG4105C29 acyl-CoA thioesterase HPG92_RS05415 ENOG4108MNP Glycoprotein polysaccharide metabolism HPG92_RS05420 ENOG41080UX Methyltransferase HPG92_RS05430 ENOG41066DG (EAL) domain protein HPG92_RS05445 ENOG4105GSJ Inner membrane protein ylaC HPG92_RS05450 ENOG4108UW5 maltose o-acetyltransferase HPG92_RS05460 ENOG4108UKR Biofilm formation regulator YbaJ HPG92_RS05465 ENOG4105BZS acriflavin resistance protein HPG92_RS05470 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPG92_RS05475 ENOG4107XI7 Tetr family transcriptional regulator HPG92_RS05480 ENOG4105EGS Mechanosensitive ion channel HPG92_RS05515 ENOG4106428 Protein of unknown function (DUF2496) HPG92_RS05520 ENOG4108URS primosomal replication protein n'' HPG92_RS05525 ENOG4105WD1 Membrane HPG92_RS05535 ENOG4107QMP dna polymerase iii subunits gamma and tau HPG92_RS05570 ENOG4107RE1 Inosine-guanosine kinase HPG92_RS05575 ENOG4105CKD glutathione-regulated potassium-efflux system protein HPG92_RS05580 ENOG4105EU0 Major facilitator Superfamily HPG92_RS05585 ENOG4105CGH 5'-nucleotidase HPG92_RS05590 ENOG4108Z66 YbaK ebsC protein HPG92_RS05595 ENOG4105MBR gumn family HPG92_RS05600 ENOG4105C59 p-type ATPase HPG92_RS05605 ENOG4108Z6Z Transcriptional regulator HPG92_RS05610 ENOG4105G5H Membrane HPG92_RS05615 ENOG4107QX8 SPFH domain, Band 7 family protein HPG92_RS05620 ENOG41083J0 (ABC) transporter HPG92_RS05625 ENOG4105C4B ABC transporter, permease HPG92_RS05630 ENOG4107QR8 Thioredoxin HPG92_RS05635 ENOG4105E1F short-chain dehydrogenase reductase HPG92_RS05640 ENOG4108UJV acyl-CoA thioesterase i HPG92_RS05645 ENOG4108I0Y (ABC) transporter HPG92_RS05650 ENOG4105CV6 ABC transporter, permease HPG92_RS05660 ENOG4105D01 (LipO)protein HPG92_RS05665 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG92_RS05670 ENOG4108UMI ABC transporter, permease HPG92_RS05680 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPG92_RS05685 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPG92_RS05690 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HPG92_RS05695 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HPG92_RS05700 ENOG4105C8N cysteinyl-tRNA synthetase HPG92_RS05705 ENOG4105WQ3 Rna-binding protein HPG92_RS05715 ENOG4108WDE Fimbrial protein HPG92_RS05725 ENOG4108AF8 Chaperone HPG92_RS05730 ENOG4105CW0 outer membrane usher protein HPG92_RS05735 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HPG92_RS05740 ENOG4108ZI2 Fimbrial protein HPG92_RS05745 ENOG4108Q9V regulatoR HPG92_RS05760 ENOG4106KCD HTH_LUXR HPG92_RS05790 ENOG4108K01 transcriptional regulator HPG92_RS05795 ENOG4107QN2 dihydrolipoyl dehydrogenase HPG92_RS05800 ENOG41066GK UPF0379 protein ykgI HPG92_RS05805 ENOG4108KBJ Inner membrane protein YkgB HPG92_RS05815 ENOG4105C85 amino acid HPG92_RS05820 ENOG4105CUY Mechanosensitive ion channel HPG92_RS05830 ENOG4105CS2 ec 3.2.1.21 HPG92_RS05840 ENOG4105VCP PTS System HPG92_RS05845 ENOG4105CK1 PTS System HPG92_RS05855 ENOG4105FDP GntR family transcriptional regulator HPG92_RS05860 ENOG4108RCM Nitroreductase HPG92_RS05865 ENOG4105MSB protein, conserved in bacteria HPG92_RS05870 ENOG41067SE Tetr family transcriptional regulator HPG92_RS05875 ENOG4105HFT AraC family transcriptional regulator HPG92_RS05880 ENOG4105WQ6 Membrane HPG92_RS05890 ENOG4108TSE Transferase HPG92_RS05895 ENOG4107RNH Outer membrane receptor FepA HPG92_RS05900 ENOG4105E93 esterase HPG92_RS05905 ENOG41085A6 mbth domain-containing protein HPG92_RS05910 ENOG4105C0W non-ribosomal peptide synthetase HPG92_RS05915 ENOG4108QY5 Ferric enterobactin transport protein HPG92_RS05920 ENOG4105E0A ABC, transporter HPG92_RS05925 ENOG4105TVJ transport system, permease HPG92_RS05930 ENOG4105DQ5 transport system permease protein HPG92_RS05940 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HPG92_RS05945 ENOG4105E4F Isochorismate synthase HPG92_RS05950 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPG92_RS05955 ENOG4105WQI isochorismatase HPG92_RS05960 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HPG92_RS05970 ENOG4105D22 carbon starvation protein HPG92_RS05975 ENOG4105VCD cytoplasmic protein HPG92_RS05980 ENOG4107SCQ Iron-containing alcohol dehydrogenase HPG92_RS05985 ENOG4105CHM Aminotransferase HPG92_RS05990 ENOG4105GTN ParB Domain Protein Nuclease HPG92_RS05995 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HPG92_RS06000 ENOG4105DQS Transcriptional regulator HPG92_RS06005 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HPG92_RS06010 ENOG4105D3R alkyl hydroperoxide reductase HPG92_RS06015 ENOG4108JU3 Alkyl hydroperoxide reductase HPG92_RS06020 ENOG4108U51 Universal stress protein HPG92_RS06025 ENOG4105E2A Dehydrogenase HPG92_RS06030 ENOG4105NXH GreA GreB family elongation factor HPG92_RS06035 ENOG4105KTS ribonuclease HPG92_RS06040 ENOG4107QPK )-transporter HPG92_RS06050 ENOG4105YGP holo-ACP synthase CitX HPG92_RS06055 ENOG4105CHY citrate lyase, alpha HPG92_RS06060 ENOG4105CI0 Citrate lyase HPG92_RS06065 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HPG92_RS06070 ENOG4105DUA (citrate (pro-3S)-lyase ligase HPG92_RS06075 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPG92_RS06080 ENOG4106YYS transcriptional regulatory protein HPG92_RS06085 ENOG4105CEE C4-dicarboxylate transporter HPG92_RS06100 ENOG4107Z6W Protein CrcB homolog HPG92_RS06120 ENOG41064T2 transcriptional regulator, lysR family HPG92_RS06130 ENOG4108Z43 UPF0250 protein HPG92_RS06135 ENOG4105DZ1 carboxypeptidase HPG92_RS06140 ENOG4105K6T rare lipoprotein A HPG92_RS06145 ENOG4105CNI cell division protein FtsW HPG92_RS06150 ENOG4105CJN penicillin-binding protein HPG92_RS06155 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HPG92_RS06160 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HPG92_RS06170 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HPG92_RS06175 ENOG4105DJF DNA polymerase III, delta' subunit HPG92_RS06185 ENOG4105C8T Leucyl-tRNA synthetase HPG92_RS06190 ENOG4107PAI alpha helical protein HPG92_RS06195 ENOG4105DU0 nucleoside hydrolase HPG92_RS06200 ENOG4105CDA abc transporter atp-binding protein HPG92_RS06205 ENOG4105DRP amino acid AbC transporter HPG92_RS06210 ENOG4105EAD ABC transporter HPG92_RS06215 ENOG4107RP9 extracellular solute-binding protein, family 3 HPG92_RS06220 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HPG92_RS06225 ENOG4108JU5 Magnesium and cobalt efflux protein HPG92_RS06235 ENOG4105C9A Phoh family HPG92_RS06245 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPG92_RS06285 ENOG4105CAQ asparagine synthetase HPG92_RS06290 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPG92_RS06295 ENOG4105E2R ROK family HPG92_RS06300 ENOG4105CE4 GlcNAc 6-P deacetylase HPG92_RS06310 ENOG4105CI1 PTS System HPG92_RS06320 ENOG4105J5J Outer membrane porin HPG92_RS06325 ENOG4105GX6 (LipO)protein HPG92_RS06330 ENOG4105CSH Transporter HPG92_RS06335 ENOG41079YP Citrate utilization protein b HPG92_RS06340 ENOG4107EFR Flavocytochrome c HPG92_RS06345 ENOG4106P55 Transcriptional regulator HPG92_RS06350 ENOG41090R7 Ferric uptake HPG92_RS06355 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HPG92_RS06360 ENOG4105NNH LexA regulated protein HPG92_RS06365 ENOG4105EV9 Alpha Beta Hydrolase HPG92_RS06370 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HPG92_RS06375 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HPG92_RS06385 ENOG4105D5Q Arginine ornithine antiporter HPG92_RS06390 ENOG4105CXN decarboxylase HPG92_RS06400 ENOG4105EEX Two component transcriptional regulator (Winged helix family HPG92_RS06405 ENOG4105C08 Histidine kinase HPG92_RS06430 ENOG4105XIQ Protein of unknown function (DUF2517) HPG92_RS06445 ENOG4105CVP deoxyribo-dipyrimidine photolyase HPG92_RS06465 ENOG4106YXT transposase HPG92_RS06470 ENOG4108WTW DNA transposition protein HPG92_RS06590 ENOG4105CF2 Mu-like prophage FluMu protein GP28 HPG92_RS06595 ENOG4105QIB mu-like prophage Flumu protein gp29 HPG92_RS06600 ENOG4108QUU Morphogenesis Protein HPG92_RS06610 ENOG4105ZS4 g protein HPG92_RS06620 ENOG4105EFV Major head subunit HPG92_RS06635 ENOG41067KA Domain of unknown function (DUF1834) HPG92_RS06645 ENOG4105TKZ Tail Sheath HPG92_RS06655 ENOG41062PQ Mu-like prophage FluMu protein gp41 HPG92_RS06665 ENOG4108NKR DNA circulation protein HPG92_RS06675 ENOG4105PZ7 Baseplate assembly protein HPG92_RS06685 ENOG4108T86 baseplate J family protein HPG92_RS06695 ENOG410685N tail fiber protein HPG92_RS06700 ENOG4105UZW Tail fiber assembly protein HPG92_RS06735 ENOG4105NI8 Cytosine-specific methyltransferase HPG92_RS06745 ENOG4107QNR UPF0135 protein HPG92_RS06750 ENOG4105P4J Allophanate hydrolase, subunit 1 HPG92_RS06775 ENOG4105BZN citrate synthase HPG92_RS06785 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HPG92_RS06790 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HPG92_RS06795 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HPG92_RS06800 ENOG4105E33 succinate dehydrogenase HPG92_RS06805 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HPG92_RS06810 ENOG4105C7S Dehydrogenase HPG92_RS06820 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPG92_RS06825 ENOG4107XVH Transcriptional regulator HPG92_RS06830 ENOG4105ETT transcriptional Regulator, LysR family HPG92_RS06835 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HPG92_RS06840 ENOG4107GFK fumarate HPG92_RS06845 ENOG4105CSV Glutaminase HPG92_RS06870 ENOG4105DJI Methylaspartate mutase, E subunit HPG92_RS06880 ENOG4107WFU Glutamate mutase subunit sigma HPG92_RS06885 ENOG4105C4M (Ubiquinol oxidase) subunit I HPG92_RS06890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPG92_RS06900 ENOG4105KJB cyd operon protein YbgE HPG92_RS06905 ENOG4107YD3 Thioesterase HPG92_RS06910 ENOG4105E02 MotA TolQ exbB proton channel HPG92_RS06920 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HPG92_RS06930 ENOG4105KCK Peptidoglycan-associated lipoprotein HPG92_RS06935 ENOG4105UFD tol-pal system protein YbgF HPG92_RS06980 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HPG92_RS06985 ENOG4105PGM cation diffusion facilitator family transporter HPG92_RS06990 ENOG4105JND homeobox protein HPG92_RS06995 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPG92_RS07000 ENOG4105EHG Permease protein HPG92_RS07005 ENOG4105E0A ABC, transporter HPG92_RS07015 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HPG92_RS07020 ENOG4105CHU acetyl-coa acetyltransferase HPG92_RS07025 ENOG4105CHR reductase HPG92_RS07040 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HPG92_RS07050 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HPG92_RS07055 ENOG4105CMR udp-glucose 4-epimerase HPG92_RS07060 ENOG4105DKW ABC transporter HPG92_RS07065 ENOG4105F4R Transcriptional regulator mode HPG92_RS07075 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPG92_RS07080 ENOG4105E0C molybdate abc transporter HPG92_RS07090 ENOG4108K4B hydrolase HPG92_RS07105 ENOG4105NBR Pectinesterase HPG92_RS07135 ENOG4108V1U phospholipid-binding protein HPG92_RS07140 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPG92_RS07155 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG92_RS07160 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPG92_RS07170 ENOG4105CHW UPF0052 protein HPG92_RS07180 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPG92_RS07190 ENOG4105M00 molybdopterin converting factor, subunit 1 HPG92_RS07195 ENOG4108ZAF Molybdopterin HPG92_RS07200 ENOG4105HFZ Membrane HPG92_RS07205 ENOG4107UXM Membrane HPG92_RS07210 ENOG4105DZQ phospholipase D Transphosphatidylase HPG92_RS07215 ENOG4105X23 Endonuclease Exonuclease phosphatase HPG92_RS07220 ENOG4105I9U inner membrane protein ybhQ HPG92_RS07225 ENOG4107QWP ABC-2 type transporter HPG92_RS07230 ENOG4107QWP ABC-2 type transporter HPG92_RS07235 ENOG4105CJ1 ABC, transporter HPG92_RS07245 ENOG4107MVR Transcriptional regulator HPG92_RS07255 ENOG4105DVT helicase HPG92_RS07260 ENOG4108MTB glycosyl transferase family HPG92_RS07265 ENOG4105VR4 UPF0379 protein ybiJ HPG92_RS07270 ENOG4105KSC Transcriptional regulator, TraR DksA family HPG92_RS07280 ENOG4105D8X mechanosensitive ion channel HPG92_RS07285 ENOG4105CDA abc transporter atp-binding protein HPG92_RS07290 ENOG4105E5Q amino acid AbC transporter HPG92_RS07295 ENOG4107R0W ABC transporter HPG92_RS07310 ENOG4108T1M outer membrane protein x HPG92_RS07315 ENOG4108I6E Sulfatase HPG92_RS07325 ENOG4105KST dependent repressor HPG92_RS07330 ENOG4105F4P )-transporter HPG92_RS07335 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPG92_RS07340 ENOG4105C5H ABC transporter HPG92_RS07345 ENOG41072TH Protein of unknown function (DUF1479) HPG92_RS07350 ENOG4108HCJ Hydrolase HPG92_RS07360 ENOG4105F1A Pyruvate formate-lyase HPG92_RS07365 ENOG4105D06 uba thif-type nad fad binding protein HPG92_RS07370 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPG92_RS07375 ENOG4105D44 asparaginase HPG92_RS07380 ENOG4108JQ6 ABC transporter HPG92_RS07385 ENOG4105DEF Extracellular solute-binding protein, family 5 HPG92_RS07390 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPG92_RS07405 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HPG92_RS07410 ENOG4105D8V Glucose sorbosone dehydrogenase HPG92_RS07420 ENOG4105DZ1 carboxypeptidase HPG92_RS07425 ENOG4107FB0 transcriptional regulator DeoR family HPG92_RS07430 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPG92_RS07435 ENOG4107QF7 multi-drug HPG92_RS07440 ENOG4108HCJ Hydrolase HPG92_RS07445 ENOG4106UW1 Major Facilitator superfamily HPG92_RS07450 ENOG4108RFG Tetr family transcriptional regulator HPG92_RS07460 ENOG4105GWF inner membrane protein YbjM HPG92_RS07465 ENOG41090BQ Glutaredoxin HPG92_RS07470 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HPG92_RS07475 ENOG4108DBC nitroreductase HPG92_RS07485 ENOG4108RMJ sensory transduction regulator HPG92_RS07490 ENOG4107RUE extracellular solute-binding protein family 1 HPG92_RS07495 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPG92_RS07500 ENOG4105F38 ABC transporter, permease HPG92_RS07505 ENOG4105D38 putrescine abc transporter HPG92_RS07510 ENOG4105RBQ inner membrane protein ybjO HPG92_RS07535 ENOG4106TNF Periplasmic binding protein HPG92_RS07540 ENOG4105DMR ABC, transporter HPG92_RS07545 ENOG4105GBT ABC transporter HPG92_RS07550 ENOG4106PMH Extracellular solute-binding protein family 3 HPG92_RS07555 ENOG4105E5Z arginine transporter ATP-binding subunit HPG92_RS07560 ENOG41064MM (LipO)protein HPG92_RS07610 ENOG4105Y50 Virulence Protein HPG92_RS07620 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HPG92_RS07625 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HPG92_RS07630 ENOG4105CGD Nad-dependent epimerase dehydratase HPG92_RS07635 ENOG4105C5W Aldolase HPG92_RS07640 ENOG4105C7K acetolactate synthase HPG92_RS07645 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPG92_RS07655 ENOG4105DWU Membrane HPG92_RS07660 ENOG4105CPB ATP-dependent endonuclease of the OLD family HPG92_RS07665 ENOG4108MJ5 VirK protein HPG92_RS07670 ENOG4105DJY efflux transporter, rnd family, mfp subunit HPG92_RS07675 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPG92_RS07680 ENOG4105VEQ Cold shock protein HPG92_RS07690 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPG92_RS07700 ENOG4105CHJ isochorismatase hydrolase HPG92_RS07705 ENOG4105EUB pirin domain protein HPG92_RS07710 ENOG4105HEI LysR family (Transcriptional regulator HPG92_RS07715 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPG92_RS07730 ENOG4108JJ8 (ABC) transporter HPG92_RS07735 ENOG4108JJ9 ABC, transporter HPG92_RS07740 ENOG4105C3M thioredoxin reductase HPG92_RS07745 ENOG4105EW9 transcriptional regulator AsnC family HPG92_RS07750 ENOG4105CNU cell division protein FtsK HPG92_RS07760 ENOG4105D1H recombination factor protein RarA HPG92_RS07770 ENOG4107QY8 reductase HPG92_RS07775 ENOG4105QAX Iron-sulfur HPG92_RS07780 ENOG4107KGK dmso reductase anchor subunit HPG92_RS07785 ENOG4105CHJ isochorismatase hydrolase HPG92_RS07795 ENOG4105F1A Pyruvate formate-lyase HPG92_RS07800 ENOG4105GUS HPG92_RS07805 ENOG4105C6N Formate acetyltransferase HPG92_RS07810 ENOG4105TMB Formate nitrite transporter HPG92_RS07815 ENOG4105DDY UPF0142 protein ycaO HPG92_RS07820 ENOG4107VMU Membrane HPG92_RS07835 ENOG4108K0D peptidase, M48 HPG92_RS07845 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HPG92_RS07850 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HPG92_RS07855 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HPG92_RS07860 ENOG4105BZ1 (ABC) transporter HPG92_RS07865 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HPG92_RS07870 ENOG4105T0Z Conserved Protein HPG92_RS07875 ENOG4105W49 UPF0434 protein HPG92_RS07885 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HPG92_RS07890 ENOG4107S90 membrAne HPG92_RS07895 ENOG4106371 Methyltransferase HPG92_RS07905 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HPG92_RS07915 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HPG92_RS07920 ENOG4105EAQ (twin-arginine translocation) pathway signal HPG92_RS07925 ENOG4105C5X domain protein HPG92_RS07935 ENOG4105CGF Aromatic amino acid aminotransferase HPG92_RS07940 ENOG4105FCK Membrane HPG92_RS07945 ENOG4105C5S asparaginyl-tRNA synthetase HPG92_RS07955 ENOG4105CD8 aminopeptidase N HPG92_RS07965 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HPG92_RS07970 ENOG4105QVC MOSC domain-containing protein HPG92_RS07980 ENOG4105C5H ABC transporter HPG92_RS07985 ENOG4105F1S paraquat-inducible protein a HPG92_RS07990 ENOG4105DY2 Paraquat-inducible protein b HPG92_RS07995 ENOG4108Q2G (LipO)protein HPG92_RS08000 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HPG92_RS08005 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HPG92_RS08010 ENOG4105DAN ATP-dependent protease HPG92_RS08020 ENOG4105UYK outer membrane protein a HPG92_RS08025 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HPG92_RS08030 ENOG4108RZ1 DNA transformation protein HPG92_RS08035 ENOG4105EM2 membrane HPG92_RS08040 ENOG410901E Membrane HPG92_RS08045 ENOG41088T4 Helicase IV HPG92_RS08050 ENOG4108Z5K methylglyoxal synthase HPG92_RS08060 ENOG4105K4P CoA-binding domain protein HPG92_RS08080 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HPG92_RS08095 ENOG4108MN8 Membrane HPG92_RS08115 ENOG4108SEH involved in lipopolysaccharide biosynthesis HPG92_RS08140 ENOG4105CVK Glutamate decarboxylase HPG92_RS08170 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HPG92_RS08180 ENOG4106HNN Invasion protein HPG92_RS08185 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell HPG92_RS08190 ENOG4106YSC HPG92_RS08205 ENOG4107ZY3 Histidine kinase HPG92_RS08210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG92_RS08215 ENOG4105VT2 5-hydroxyisourate hydrolase HPG92_RS08220 ENOG4107UWN reductase HPG92_RS08230 ENOG4108V8F Transcriptional regulator, MarR family HPG92_RS08240 ENOG4105C26 Dehydrogenase HPG92_RS08245 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HPG92_RS08300 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HPG92_RS08305 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HPG92_RS08310 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPG92_RS08315 ENOG4105D6F Phosphatase HPG92_RS08320 ENOG4105XH3 HPG92_RS08325 ENOG4105CS1 NAD(P)H quinone oxidoreductase HPG92_RS08330 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HPG92_RS08335 ENOG4108R86 Transcriptional regulator HPG92_RS08350 ENOG4105CK7 Sodium proline symporter HPG92_RS08355 ENOG4105D5M phosphate starvation-inducible protein HPG92_RS08360 ENOG4105QEK Transcriptional regulator HPG92_RS08365 ENOG4107RJ1 sodium solute HPG92_RS08385 ENOG4108QGT oligogalacturonate-specific porin HPG92_RS08390 ENOG4105JHE Major Facilitator Superfamily HPG92_RS08395 ENOG4107RJ5 oxidoreductase HPG92_RS08415 ENOG4107XHZ cytoplasmic chaperone TorD family protein HPG92_RS08420 ENOG4108UQ5 membrane protein YcdZ HPG92_RS08425 ENOG4105P8Q Curli production assembly transport component CsgG HPG92_RS08430 ENOG4108WYR Curli production assembly transport component, CsgF HPG92_RS08435 ENOG4108XDW curli assembly protein CsgE HPG92_RS08440 ENOG41086KC Transcriptional regulator HPG92_RS08445 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HPG92_RS08450 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HPG92_RS08455 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HPG92_RS08460 ENOG41068SS HPG92_RS08470 ENOG4107RZC phospholipase d HPG92_RS08485 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HPG92_RS08490 ENOG4105NAC (LipO)protein HPG92_RS08495 ENOG4108W47 Acidic protein msyB HPG92_RS08515 ENOG4108YYC ycei family HPG92_RS08520 ENOG4105DS1 cytochrome b561 HPG92_RS08525 ENOG4106974 biofilm formation HPG92_RS08535 ENOG4105PVA Biofilm formation regulatory protein BssS HPG92_RS08540 ENOG4105MEA DNA damage-inducible protein i HPG92_RS08545 ENOG4105EKE dihydroorotase HPG92_RS08550 ENOG4105F3T (LipO)protein HPG92_RS08555 ENOG4105E9S glutaredoxin 2 HPG92_RS08565 ENOG4105D9U N-acetyltransferase HPG92_RS08575 ENOG4105EP9 oxidoreductase HPG92_RS08580 ENOG4105CJR Integral membrane protein (MviN HPG92_RS08585 ENOG4105QVD Flagella synthesis protein FlgN HPG92_RS08590 ENOG4105M9M anti-sigma28 factor FlgM HPG92_RS08595 ENOG4105CKS Flagella basal body P-ring formation protein flgA HPG92_RS08600 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPG92_RS08605 ENOG4108ZC9 flagellar basal-body rod protein flgc HPG92_RS08610 ENOG4105W00 Flagellar hook capping protein HPG92_RS08615 ENOG4105BZE flagellar hook protein, FlgE HPG92_RS08620 ENOG4108KPB Flagellar basal-body rod protein FlgF HPG92_RS08625 ENOG4105CGA flagellar basal-body rod protein FlgG HPG92_RS08635 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HPG92_RS08640 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HPG92_RS08645 ENOG4105E1Q flagellar hook-associated protein HPG92_RS08650 ENOG4105DTJ flagellar hook-associated protein HPG92_RS08655 ENOG4107QQB Ribonuclease E HPG92_RS08660 ENOG4105EI2 Pseudouridine synthase HPG92_RS08670 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HPG92_RS08690 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPG92_RS08695 ENOG4105CHR reductase HPG92_RS08700 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPG92_RS08705 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPG92_RS08710 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HPG92_RS08715 ENOG4105HHA aminodeoxychorismate lyase HPG92_RS08725 ENOG4107QRG dna polymerase iii HPG92_RS08730 ENOG4105F8V Hydrolase, tatD family HPG92_RS08735 ENOG4105CI1 PTS System HPG92_RS08740 ENOG4105K59 histidine triad (HIT) protein HPG92_RS08745 ENOG41090DQ Lipoprotein HPG92_RS08750 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HPG92_RS08765 ENOG4105D0Y UPF0227 protein HPG92_RS08775 ENOG4107MBR 17 kDa surface antigen HPG92_RS08780 ENOG4108IND Tetr family transcriptional regulator HPG92_RS08785 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HPG92_RS08795 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPG92_RS08800 ENOG4108JA2 transcriptioN-repair coupling factor HPG92_RS08805 ENOG4105D60 lipoprotein releasing system transmembrane protein HPG92_RS08810 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPG92_RS08815 ENOG4105D60 lipoprotein releasing system transmembrane protein HPG92_RS08825 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPG92_RS08830 ENOG4108HM4 ABC transporter HPG92_RS08835 ENOG4105D38 putrescine abc transporter HPG92_RS08850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPG92_RS08860 ENOG4105EZE Cupin 4 family protein HPG92_RS08875 ENOG4107QTF adenylosuccinate lyase HPG92_RS08900 ENOG4108R99 pseudouridine synthase HPG92_RS08905 ENOG4108HMX isocitrate dehydrogenase (NADP) HPG92_RS08935 ENOG4105NVB glycoside hydrolase, family 19 HPG92_RS08940 ENOG4108YV9 Protein of unknown function (DUF2514) HPG92_RS08995 ENOG4105QYK bacteriophage lambda Bor protein homolog HPG92_RS09015 ENOG4105Y50 Virulence Protein HPG92_RS09020 ENOG4106F2Y RICIN HPG92_RS09025 ENOG41060EU Cold shock-like protein HPG92_RS09035 ENOG4105H38 Membrane HPG92_RS09060 ENOG4108ZNX Heat shock protein HPG92_RS09070 ENOG4108VKM cytochrome b561 HPG92_RS09080 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HPG92_RS09095 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HPG92_RS09100 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HPG92_RS09105 ENOG4105D64 Mechanosensitive ion channel HPG92_RS09120 ENOG4108MEK Metal-binding protein YodA HPG92_RS09135 ENOG4108Z6Z Transcriptional regulator HPG92_RS09145 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HPG92_RS09155 ENOG4108YS1 cytoplasmic protein HPG92_RS09160 ENOG4105YP6 Domain of unknown function (DUF1869) HPG92_RS09170 ENOG4105Y3U Transglycosylase-associated protein HPG92_RS09175 ENOG4106G4W HPG92_RS09180 ENOG4105UCG Domain of unknown function (DUF333) HPG92_RS09190 ENOG4105K78 MarR family Transcriptional regulator HPG92_RS09195 ENOG4105DJ2 Major Facilitator Superfamily HPG92_RS09200 ENOG4105R1U AraC Family Transcriptional Regulator HPG92_RS09215 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HPG92_RS09220 ENOG4108KHP Diguanylate cyclase HPG92_RS09235 ENOG4105CYN Serine protein kinase HPG92_RS09240 ENOG4105GNX MltA-interacting MipA family protein HPG92_RS09245 ENOG4105C4X radical SAM domain protein HPG92_RS09255 ENOG4105DSB aldose 1-epimerase HPG92_RS09260 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPG92_RS09270 ENOG4105VUT cytoplasmic protein HPG92_RS09275 ENOG4108RWI nicotinamidase HPG92_RS09280 ENOG4105HDK L-asparaginase HPG92_RS09285 ENOG4105D07 Signal peptide peptidase, SppA HPG92_RS09290 ENOG41069NU Nitroreductase HPG92_RS09295 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HPG92_RS09300 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPG92_RS09305 ENOG4105D82 Glutamate dehydrogenase HPG92_RS09310 ENOG4105MTM Protein of unknown function (DUF1496) HPG92_RS09315 ENOG4105M6F mutator MutT protein HPG92_RS09320 ENOG4105CGK Exodeoxyribonuclease III HPG92_RS09350 ENOG4108SPG Periplasmic Protein HPG92_RS09355 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HPG92_RS09365 ENOG4105KKI DNA-binding transcriptional activator OsmE HPG92_RS09370 ENOG4105VZJ PTS System HPG92_RS09375 ENOG4105CK1 PTS System HPG92_RS09380 ENOG4105VCP PTS System HPG92_RS09385 ENOG4105EZV Transcriptional regulator HPG92_RS09390 ENOG4105F8D glycoside hydrolase family 4 HPG92_RS09400 ENOG4105CH6 catalase HPG92_RS09410 ENOG4108ETY sodium dicarboxylate symporter HPG92_RS09415 ENOG4107K5X Membrane-bound metal-dependent hydrolase HPG92_RS09420 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HPG92_RS09425 ENOG4107PN8 YfeABCD locus regulator HPG92_RS09435 ENOG4105P10 Uncharacterized protein ydiZ HPG92_RS09440 ENOG4105DE4 1-phosphofructokinase HPG92_RS09445 ENOG4108NE3 Salt-induced outer membrane protein HPG92_RS09495 ENOG4105C3G gtp-binding protein HPG92_RS09505 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HPG92_RS09510 ENOG4105CHH sulfate transporter HPG92_RS09515 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HPG92_RS09530 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HPG92_RS09540 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPG92_RS09545 ENOG4108YY7 Invasion gene expression up-regulator SirB HPG92_RS09550 ENOG41063JG Transcriptional regulator HPG92_RS09555 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HPG92_RS09560 ENOG4108RS6 transposase HPG92_RS09565 ENOG4105EWV Sodium calcium exchanger membrane region HPG92_RS09570 ENOG4105WS7 Cation transport regulator HPG92_RS09575 ENOG41090EX DsrE family HPG92_RS09580 ENOG4105ID0 Putative invasin HPG92_RS09585 ENOG4105WH1 Two component transcriptional regulator luxr family HPG92_RS09595 ENOG4105DQQ Major facilitator superfamily MFS_1 HPG92_RS09600 ENOG4105CRU nitrate reductase, alpha subunit HPG92_RS09605 ENOG4108IUE nitrate reductase beta subunit HPG92_RS09610 ENOG4105R3A Nitrate reductase HPG92_RS09615 ENOG41076YT nitrate reductase, gamma subunit HPG92_RS09650 ENOG4105CIY formyltetrahydrofolate deformylase HPG92_RS09660 ENOG4105D78 K07001 NTE family protein HPG92_RS09665 ENOG4105I93 response regulator HPG92_RS09670 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPG92_RS09685 ENOG4105C0A alcohol dehydrogenase HPG92_RS09690 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HPG92_RS09695 ENOG4107QSI ABC, transporter HPG92_RS09700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPG92_RS09705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG92_RS09710 ENOG4105C3U ABC transporter HPG92_RS09715 ENOG4108JQ7 (ABC) transporter HPG92_RS09720 ENOG4105EYW Ion transport protein HPG92_RS09740 ENOG4105K9H YciI-like protein HPG92_RS09745 ENOG410822N TonB family HPG92_RS09750 ENOG4105NAU thioesterase Superfamily protein HPG92_RS09765 ENOG4105PI0 Ferredoxin HPG92_RS09770 ENOG4105EIF outer membrane protein W HPG92_RS09775 ENOG4105WEF catalase HPG92_RS09780 ENOG4108N8X transition metal ion binding HPG92_RS09785 ENOG4108Z9Z response to DNA damage stimulus HPG92_RS09805 ENOG4105DK0 Indole-3-glycerol phosphate synthase HPG92_RS09810 ENOG4108EFP Anthranilate synthase component II HPG92_RS09815 ENOG4105CRQ synthase (Component I) HPG92_RS09825 ENOG4105DB7 PHP domain protein HPG92_RS09830 ENOG4107RTD sua5 ycio yrdc ywlc family protein HPG92_RS09835 ENOG4105FE9 pseudouridine synthase HPG92_RS09840 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HPG92_RS09845 ENOG4105UBK short-chain dehydrogenase reductase HPG92_RS09850 ENOG4105ERU peptidase HPG92_RS09855 ENOG4105RKX Protein of unknown function (DUF2498) HPG92_RS09860 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPG92_RS09865 ENOG4107R11 Transcriptional regulator HPG92_RS09880 ENOG4107QM5 aconitate hydratase HPG92_RS09885 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HPG92_RS09890 ENOG4105EYK Phosphatidylglycerophosphatase B HPG92_RS09895 ENOG4105Q4A inner membrane protein yciS HPG92_RS09900 ENOG4105CFV Tetratricopeptide repeat protein HPG92_RS09910 ENOG4108ZJT translation initiation factor, Sui1 HPG92_RS09915 ENOG41061RM osmotically inducible lipoprotein HPG92_RS09920 ENOG4105N2W Transcriptional regulator HPG92_RS09930 ENOG4105BZU Histidine kinase HPG92_RS09945 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HPG92_RS09970 ENOG4108JQ2 peptide transport system atp-binding protein HPG92_RS09975 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HPG92_RS09980 ENOG4108EU3 peptide transport system, permease HPG92_RS10035 ENOG4108EKA peptide transport system, permease HPG92_RS10040 ENOG4108J59 Extracellular solute-binding protein, family 5 HPG92_RS10045 ENOG4105E51 psp operon transcriptional activator HPG92_RS10050 ENOG41087YS Phage shock protein A HPG92_RS10055 ENOG4105YYT phage shock protein B HPG92_RS10060 ENOG4105FM1 phage shock protein C HPG92_RS10065 ENOG4105NNG Peripheral inner membrane phage-shock protein HPG92_RS10070 ENOG4105K8Z Phage shock protein HPG92_RS10075 ENOG4105CM6 amino acid regulated cytosolic protein HPG92_RS10085 ENOG4108JU8 Transcriptional regulator HPG92_RS10095 ENOG4105EQ2 LysR family Transcriptional regulator HPG92_RS10105 ENOG4105C2C drug resistance transporter, Bcr CflA HPG92_RS10120 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPG92_RS10125 ENOG4107S8C mandelate racemase muconate lactonizing HPG92_RS10130 ENOG4105KXI murein peptide amidase A HPG92_RS10135 ENOG4107QSI ABC, transporter HPG92_RS10145 ENOG4105DFP Integrase HPG92_RS10160 ENOG4108W9T type 1 fimbriae regulatory protein HPG92_RS10165 ENOG4105MX3 Fimbrial HPG92_RS10170 ENOG4108VCD Chaperone HPG92_RS10225 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPG92_RS10235 ENOG4105C85 amino acid HPG92_RS10280 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HPG92_RS10290 ENOG4108RVA ribokinase HPG92_RS10295 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HPG92_RS10300 ENOG4108XFH Transcriptional regulator HPG92_RS10310 ENOG4106PHM regulatory protein HPG92_RS10330 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPG92_RS10350 ENOG4105D64 Mechanosensitive ion channel HPG92_RS10355 ENOG4105S5I Membrane HPG92_RS10360 ENOG4105Q9Y Universal stress protein HPG92_RS10365 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HPG92_RS10370 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPG92_RS10375 ENOG4108DG9 Smr protein MutS2 HPG92_RS10395 ENOG4105C1J atp-dependent rna helicase HPG92_RS10415 ENOG410814C multidrug resistance protein HPG92_RS10420 ENOG4108RW8 Universal stress protein F HPG92_RS10425 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HPG92_RS10435 ENOG4105IKK cytoplasmic protein HPG92_RS10440 ENOG41090X5 Heat shock protein hslJ HPG92_RS10445 ENOG4105C5I Dehydrogenase HPG92_RS10450 ENOG4107H52 Dicarboxylate transport HPG92_RS10455 ENOG410689M (LipO)protein HPG92_RS10460 ENOG4105WXT Conserved Protein HPG92_RS10475 ENOG4105CQ7 ATP-dependent helicase HPG92_RS10480 ENOG4107DB1 DUF218 domain HPG92_RS10485 ENOG4105CPW cytochrome b561 HPG92_RS10490 ENOG4108WF3 methyltransferase HPG92_RS10530 ENOG4105DDW LysR family Transcriptional regulator HPG92_RS10535 ENOG4105E32 cytoplasmic protein HPG92_RS10545 ENOG4105DJ9 glucan biosynthesis protein HPG92_RS10550 ENOG4108YYC ycei family HPG92_RS10565 ENOG4108PQ7 sgc region transcriptional regulator HPG92_RS10640 ENOG4108WN0 inhibitor of vertebrate lysozyme HPG92_RS10650 ENOG4105CH2 amidohydrolase HPG92_RS10655 ENOG4105EN6 Membrane HPG92_RS10670 ENOG4108Z9I -acetyltransferase HPG92_RS10675 ENOG4107WE3 acetyltransferase YdcK HPG92_RS10680 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HPG92_RS10685 ENOG41088CC tellurite resistance protein tehB HPG92_RS10690 ENOG4108KKZ (LipO)protein HPG92_RS10725 ENOG4108JCI Transcriptional regulator HPG92_RS10730 ENOG4105CFP Peptidase U32 HPG92_RS10735 ENOG4105RR0 Protein of unknown function (DUF2554) HPG92_RS10745 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPG92_RS10765 ENOG4108UQS dipeptidase HPG92_RS10770 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPG92_RS10785 ENOG410654E Membrane HPG92_RS10805 ENOG4105R71 cytoplasmic protein HPG92_RS10815 ENOG4108Z7F N-acetyltransferase HPG92_RS10820 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HPG92_RS10825 ENOG4108WYP Transcriptional regulator HPG92_RS10830 ENOG4105CHB tonB-dependent Receptor HPG92_RS10835 ENOG4108NS2 receptor HPG92_RS10840 ENOG4105SUV lipoprotein YgdR HPG92_RS10845 ENOG4105C85 amino acid HPG92_RS10860 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPG92_RS10895 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPG92_RS10900 ENOG4108MG3 formate dehydrogenase HPG92_RS10920 ENOG4105TPS biofilm-dependent modulation protein HPG92_RS10925 ENOG4108Z9K Osmotically inducible protein HPG92_RS10930 ENOG4105XXV Acid-resistance protein HPG92_RS10940 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPG92_RS10955 ENOG4105C87 Aminotransferase class I and II HPG92_RS10985 ENOG4105F5W AtP-binding protein HPG92_RS10990 ENOG4105D70 Integrase catalytic subunit HPG92_RS11075 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HPG92_RS11100 ENOG4108I5G Major Facilitator superfamily HPG92_RS11105 ENOG4105CPQ Dehydrogenase HPG92_RS11110 ENOG4105C6F GntR Family Transcriptional Regulator HPG92_RS11125 ENOG4105DPX Hydrogenase, large subunit HPG92_RS11130 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HPG92_RS11135 ENOG4108USZ hydrogenase HPG92_RS11150 ENOG4105MVP hydrogenase-1 operon protein HyaF HPG92_RS11200 ENOG4105FFC UPF0187 protein HPG92_RS11210 ENOG4105M0C cytoplasmic protein HPG92_RS11220 ENOG4105C26 Dehydrogenase HPG92_RS11225 ENOG4105EGI Transcriptional regulator HPG92_RS11240 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HPG92_RS11245 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HPG92_RS11250 ENOG4106DNR multiple antibiotic resistance protein HPG92_RS11255 ENOG4108ZXC Two component transcriptional regulator, luxr family HPG92_RS11265 ENOG4108594 Permease of the drug metabolite transporter HPG92_RS11270 ENOG4105E5W Transporter HPG92_RS11280 ENOG4108YDI single-species biofilm formation on inanimate substrate HPG92_RS11285 ENOG4108WTK competence damage-inducible protein HPG92_RS11295 ENOG4105DGW oligopeptidase A HPG92_RS11300 ENOG4105EMU Dehydrogenase HPG92_RS11305 ENOG4107XBN GntR Family Transcriptional Regulator HPG92_RS11310 ENOG41061EV selenium-binding protein YdfZ HPG92_RS11315 ENOG4105DEI Mannitol dehydrogenase HPG92_RS11325 ENOG4105CPQ Dehydrogenase HPG92_RS11345 ENOG4108MK9 spermidine N(1)-acetyltransferase HPG92_RS11355 ENOG4105KBG Protein of unknown function (DUF1161) HPG92_RS11360 ENOG4107QY8 reductase HPG92_RS11365 ENOG4105C3J Cysteine desulfurase HPG92_RS11370 ENOG4105QAX Iron-sulfur HPG92_RS11375 ENOG4107KGK dmso reductase anchor subunit HPG92_RS11380 ENOG4108NEM leader-binding protein dmsD HPG92_RS11385 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HPG92_RS11390 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HPG92_RS11395 ENOG4105E90 ABC transporter HPG92_RS11400 ENOG4108IJ8 ABC transporter HPG92_RS11405 ENOG4105CMQ Chloride channel HPG92_RS11410 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPG92_RS11415 ENOG4105DAG ROK family HPG92_RS11420 ENOG4106NZI LysR family Transcriptional regulator HPG92_RS11425 ENOG4105D94 Major Facilitator Superfamily HPG92_RS11435 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HPG92_RS11450 ENOG4105DSF transport protein HPG92_RS11455 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPG92_RS11460 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPG92_RS11465 ENOG4105C5D exported protein HPG92_RS11470 ENOG4105D5Q Arginine ornithine antiporter HPG92_RS11475 ENOG4105RA2 Membrane HPG92_RS11480 ENOG4107EXC regulatoR HPG92_RS11485 ENOG4105FCK Membrane HPG92_RS11490 ENOG4108RS6 transposase HPG92_RS11495 ENOG4105CPN adenine deaminase HPG92_RS11500 ENOG4105JJR Histidine kinase HPG92_RS11510 ENOG4105C9Q fumarate hydratase class II HPG92_RS11515 ENOG4107GFK fumarate HPG92_RS11520 ENOG4105EIP mannose-6-phosphate isomerase HPG92_RS11525 ENOG4106J39 exported protein HPG92_RS11530 ENOG4107P2S Transcriptional regulator HPG92_RS11535 ENOG4105CI1 PTS System HPG92_RS11540 ENOG4105C87 Aminotransferase class I and II HPG92_RS11550 ENOG4105D9R oxidoreductase HPG92_RS11555 ENOG4106C6R beta-lactam resistance protein HPG92_RS11565 ENOG4105M9B inner membrane protein ydgK HPG92_RS11590 ENOG4108UQQ Electron transport complex HPG92_RS11600 ENOG4105CSM endonuclease III HPG92_RS11605 ENOG4105DUX Transporter HPG92_RS11610 ENOG4108K3A Glutathione S-transferase HPG92_RS11620 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HPG92_RS11630 ENOG410642K Lysozyme inhibitor HPG92_RS11640 ENOG4108XTF Outer Membrane Lipoprotein HPG92_RS11655 ENOG4105Y49 secretion protein, HlyD family HPG92_RS11660 ENOG4105DSW Fusaric acid resistance protein HPG92_RS11665 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG92_RS11670 ENOG4107RGM aldo keto reductase HPG92_RS11675 ENOG4105XZD Fe-S protein HPG92_RS11680 ENOG4108WUH Transcriptional regulator, TetR family HPG92_RS11685 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPG92_RS11690 ENOG4108UYE Lactoylglutathione lyase HPG92_RS11695 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HPG92_RS11700 ENOG4105M2J Glutaredoxin HPG92_RS11705 ENOG4105K4H Nlp p60 protein HPG92_RS11710 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG92_RS11725 ENOG4105F52 Transcriptional regulator HPG92_RS11730 ENOG4105CZQ inner membrane transport protein YdhC HPG92_RS11735 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPG92_RS11740 ENOG4108R6K riboflavin synthase, subunit alpha HPG92_RS11765 ENOG4108TN6 type iii secretion HPG92_RS11770 ENOG41083GP type iii secretion HPG92_RS11775 ENOG4108HHI Type III secretion system protein HPG92_RS11780 ENOG41063Q7 Type III secretion system protein HPG92_RS11795 ENOG4108JIR Flagellum-specific ATP synthase HPG92_RS11805 ENOG4106H1D secretion system apparatus protein HPG92_RS11815 ENOG4106563 type III secretion system apparatus protein HPG92_RS11865 ENOG4106FZW pathogenicity island effector protein HPG92_RS11870 ENOG4108SZ7 secretion system effector HPG92_RS11880 ENOG4105ZQI secreted protein HPG92_RS11910 ENOG4105BZU Histidine kinase HPG92_RS11920 ENOG4108XDN Transcriptional regulator HPG92_RS11925 ENOG4107SEY Conserved Protein HPG92_RS11930 ENOG4105RFR Protein of unknown function (DUF2767) HPG92_RS11935 ENOG4108ZXC Two component transcriptional regulator, luxr family HPG92_RS11940 ENOG4106AFQ Histidine kinase HPG92_RS11945 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPG92_RS11950 ENOG4106WHD Tetrathionate reductase HPG92_RS11955 ENOG4105DB1 molybdopterin oxidoreductase HPG92_RS11960 ENOG4108RVA ribokinase HPG92_RS11970 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) HPG92_RS11975 ENOG4105CUB amino acid HPG92_RS11980 ENOG4105CA9 Pyruvate kinase HPG92_RS11990 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPG92_RS12005 ENOG4105JRK feS assembly protein SufD HPG92_RS12010 ENOG4105C3K feS assembly ATPase SufC HPG92_RS12015 ENOG4105DIW FeS assembly protein SUFB HPG92_RS12020 ENOG4108Z4V iron-sulfur cluster assembly HPG92_RS12025 ENOG4108ETY sodium dicarboxylate symporter HPG92_RS12030 ENOG410671Z uncharacterized protein ydiH HPG92_RS12035 ENOG4105KA0 thioesterase Superfamily protein HPG92_RS12040 ENOG4105CQB FAD linked oxidase domain protein HPG92_RS12045 ENOG4105IPI Membrane HPG92_RS12055 ENOG4105FF2 Type I DHQase HPG92_RS12060 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPG92_RS12070 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPG92_RS12080 ENOG4105CNG UPF0061 protein HPG92_RS12090 ENOG4108QBX (LipO)protein HPG92_RS12100 ENOG4108V06 Glutathione peroxidase HPG92_RS12110 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HPG92_RS12115 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HPG92_RS12135 ENOG41082NX 50s ribosomal protein l35 HPG92_RS12140 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HPG92_RS12155 ENOG4105KT5 UmuD protein HPG92_RS12190 ENOG4105ENH Sulfatase HPG92_RS12195 ENOG4105C4X radical SAM domain protein HPG92_RS12210 ENOG4108YTN IIa component HPG92_RS12215 ENOG4105F3R pts system mannose fructose sorbose family iid HPG92_RS12220 ENOG4105ETZ PTS System HPG92_RS12225 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HPG92_RS12230 ENOG4105E98 transcriptional regulator DeoR family HPG92_RS12235 ENOG4105CBG Sulfatase HPG92_RS12240 ENOG4108QGT oligogalacturonate-specific porin HPG92_RS12245 ENOG4105E3S small subunit HPG92_RS12255 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HPG92_RS12260 ENOG4108USZ hydrogenase HPG92_RS12265 ENOG4108VXY Hydrogenase-1 operon protein HyaE HPG92_RS12270 ENOG4105MVP hydrogenase-1 operon protein HyaF HPG92_RS12275 ENOG4105C4M (Ubiquinol oxidase) subunit I HPG92_RS12280 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPG92_RS12290 ENOG4105D82 Glutamate dehydrogenase HPG92_RS12305 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HPG92_RS12315 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPG92_RS12325 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPG92_RS12335 ENOG4105ED1 spovr family HPG92_RS12350 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HPG92_RS12360 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HPG92_RS12375 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HPG92_RS12390 ENOG4107QMS site-determining protein HPG92_RS12400 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HPG92_RS12405 ENOG4105CEY Amp-dependent synthetase and ligase HPG92_RS12410 ENOG4105Y4Z Outer Membrane Lipoprotein HPG92_RS12415 ENOG41072GX Peptidase M22 Glycoprotease HPG92_RS12420 ENOG4105DVT helicase HPG92_RS12425 ENOG4105M4H endoribonuclease L-psp HPG92_RS12430 ENOG4105X5C UPF0181 protein HPG92_RS12435 ENOG4105CRQ synthase (Component I) HPG92_RS12445 ENOG4105EJQ L-serine dehydratase HPG92_RS12450 ENOG4107XTP (EAL) domain protein HPG92_RS12455 ENOG4105EE5 Membrane protein terC HPG92_RS12460 ENOG4105DAS pts system HPG92_RS12465 ENOG4105ETZ PTS System HPG92_RS12470 ENOG4105F3R pts system mannose fructose sorbose family iid HPG92_RS12485 ENOG4105DHI Methyltransferase HPG92_RS12490 ENOG4105CJN penicillin-binding protein HPG92_RS12505 ENOG4105Q3Y exported protein HPG92_RS12510 ENOG4106CCY Protein MgrB homolog HPG92_RS12520 ENOG4105J4Q Transcriptional regulator HPG92_RS12525 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG92_RS12530 ENOG4108RS6 transposase HPG92_RS12535 ENOG4105D0M Protease HtpX homolog HPG92_RS12540 ENOG4105CN1 protease HPG92_RS12550 ENOG4108ZGC gaf domain protein HPG92_RS12555 ENOG4105H2K paraquat-inducible protein a HPG92_RS12560 ENOG4105DY2 Paraquat-inducible protein b HPG92_RS12570 ENOG4105WT8 Protein of unknown function (DUF1480) HPG92_RS12575 ENOG4105UVW uncharacterized protein yebW HPG92_RS12580 ENOG4108R1E Serine threonine protein phosphatase 1 HPG92_RS12585 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling HPG92_RS12630 ENOG4105NKT exported protein HPG92_RS12635 ENOG4108PNC copper resistance HPG92_RS12640 ENOG4105FXM Copper resistance protein HPG92_RS12645 ENOG4105MPK DNA polymerase III subunit theta HPG92_RS12650 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPG92_RS12655 ENOG4105UMD exodeoxyribonuclease X HPG92_RS12660 ENOG4105CUG Oligopeptidase b HPG92_RS12665 ENOG4108Q2J Inner membrane protein YebE HPG92_RS12675 ENOG4105X2V dna damage-inducible protein HPG92_RS12680 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HPG92_RS12685 ENOG4108UHU Aldolase HPG92_RS12690 ENOG4105C01 Dihydroxy-acid dehydratase HPG92_RS12695 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPG92_RS12700 ENOG4106KNT transcriptional regulator HPG92_RS12705 ENOG4105CA9 Pyruvate kinase HPG92_RS12715 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HPG92_RS12720 ENOG4108RS6 transposase HPG92_RS12725 ENOG4105DR5 peptidase HPG92_RS12730 ENOG4105NXV High-affinity zinc uptake system protein HPG92_RS12740 ENOG4105FAV ABC, transporter HPG92_RS12750 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HPG92_RS12760 ENOG4105CDY transcriptional regulatory protein HPG92_RS12765 ENOG4108TIT dATP pyrophosphohydrolase HPG92_RS12775 ENOG4105D3W isochorismatase HPG92_RS12780 ENOG41081XQ Conserved Protein HPG92_RS12785 ENOG4105WJG Glutathione HPG92_RS12795 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HPG92_RS12805 ENOG4106ZCM YecM protein HPG92_RS12820 ENOG4105F5H Glycosyl Hydrolase Family 88 HPG92_RS12825 ENOG4105IRD Flagellar protein FlhE HPG92_RS12830 ENOG4105D7B Flagellar biosynthesis protein flha HPG92_RS12835 ENOG4105D00 flagellar biosynthetic protein flhB HPG92_RS12840 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HPG92_RS12845 ENOG4108VYJ response regulator receiver protein HPG92_RS12855 ENOG4105BZU Histidine kinase HPG92_RS12860 ENOG4105C8Q Methyl-accepting chemotaxis HPG92_RS12865 ENOG4108V3W Chemotaxis protein, CheW HPG92_RS12870 ENOG4105CBS Chea signal transduction histidine kinase HPG92_RS12875 ENOG4105ER2 Ompa motb domain protein HPG92_RS12880 ENOG4107RD7 Flagellar Motor Protein, MotA HPG92_RS12885 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HPG92_RS12890 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HPG92_RS12900 ENOG4108VA4 Universal stress protein HPG92_RS12910 ENOG4108K4C ec 3.1.3.12 HPG92_RS12925 ENOG4108UEC Ferritin-like protein HPG92_RS12930 ENOG4105N4N Protein of unknown function (DUF2766) HPG92_RS12940 ENOG4105P23 (LipO)protein HPG92_RS12945 ENOG41090A1 ferritin HPG92_RS12950 ENOG4105VVZ metal-binding protein HPG92_RS12955 ENOG4105E0U tyrosine-specific transport protein HPG92_RS13015 ENOG4105WH1 Two component transcriptional regulator luxr family HPG92_RS13020 ENOG4105XVG cytoplasmic protein HPG92_RS13025 ENOG4105VJY transcriptional regulator HPG92_RS13030 ENOG4105CDA abc transporter atp-binding protein HPG92_RS13035 ENOG4105E5Q amino acid AbC transporter HPG92_RS13040 ENOG4105K6H D-cysteine desulfhydrase HPG92_RS13045 ENOG4105EAB amino acid AbC transporter HPG92_RS13050 ENOG4108M9K flagella biosynthesis protein FliZ HPG92_RS13055 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG92_RS13065 ENOG4105I03 Flagellin HPG92_RS13070 ENOG4105DTS flagellar hook-associated HPG92_RS13075 ENOG4105MQ3 flagellar protein FliS HPG92_RS13085 ENOG4105E5K Alpha-amylase HPG92_RS13090 ENOG4105JCU Inherit from NOG: (Lipo)protein HPG92_RS13110 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HPG92_RS13115 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HPG92_RS13120 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPG92_RS13125 ENOG41090PJ Flagellar assembly protein HPG92_RS13130 ENOG4108JIR Flagellum-specific ATP synthase HPG92_RS13135 ENOG4105GSA Flagellar export protein flij HPG92_RS13140 ENOG4105WF4 Flagellar hook-length control protein HPG92_RS13145 ENOG4107ZI8 flagellar basal body-associated protein flil HPG92_RS13150 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPG92_RS13155 ENOG4105DD5 Flagellar motor switch protein HPG92_RS13160 ENOG4105K0P flagellar biosynthesis protein HPG92_RS13165 ENOG4105CN7 Flagellar biosynthetic protein FliP HPG92_RS13170 ENOG4105VS8 Flagellar biosynthetic protein fliq HPG92_RS13175 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HPG92_RS13180 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HPG92_RS13190 ENOG4105YX3 cellular response to acidity HPG92_RS13195 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase HPG92_RS13200 ENOG4105BZU Histidine kinase HPG92_RS13205 ENOG4105VNZ cytoplasmic protein HPG92_RS13210 ENOG4105CKW Inner membrane protein yedI HPG92_RS13215 ENOG4105FDR Membrane HPG92_RS13220 ENOG41090BB DNA mismatch endonuclease (vsr) HPG92_RS13225 ENOG4105DVF Cytosine-specific methyltransferase HPG92_RS13230 ENOG4105EST Metal Dependent Phosphohydrolase HPG92_RS13235 ENOG4105Y0K Inner membrane protein YedR HPG92_RS13240 ENOG4105FCK Membrane HPG92_RS13305 ENOG4105FYV Amp nucleosidase HPG92_RS13365 ENOG4108M0I Transcriptional regulator HPG92_RS13385 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HPG92_RS13390 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPG92_RS13410 ENOG4105UQX Mate efflux family protein HPG92_RS13460 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPG92_RS13475 ENOG41090HJ UPF0265 protein HPG92_RS13480 ENOG4105DR8 Membrane HPG92_RS13485 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HPG92_RS13490 ENOG4105DZ1 carboxypeptidase HPG92_RS13495 ENOG4108NWD Cytochrome HPG92_RS13500 ENOG4105QAX Iron-sulfur HPG92_RS13505 ENOG4108J2R molybdopterin oxidoreductase HPG92_RS13525 ENOG4105UZW Tail fiber assembly protein HPG92_RS13530 ENOG410685N tail fiber protein HPG92_RS13620 ENOG4105M6F mutator MutT protein HPG92_RS13655 ENOG4108YV9 Protein of unknown function (DUF2514) HPG92_RS13660 ENOG4105NVB glycoside hydrolase, family 19 HPG92_RS13800 ENOG4105DFE Dna adenine methylase HPG92_RS13810 ENOG4105DFP Integrase HPG92_RS13815 ENOG4105CJB Exodeoxyribonuclease I HPG92_RS13825 ENOG4105CUB amino acid HPG92_RS13835 ENOG4105EQ1 Transcriptional regulator HPG92_RS13840 ENOG4107SRH Nad-dependent epimerase dehydratase HPG92_RS13855 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HPG92_RS13865 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HPG92_RS13870 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HPG92_RS13885 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HPG92_RS13890 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HPG92_RS13895 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPG92_RS13900 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HPG92_RS13915 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPG92_RS13955 ENOG4105KPE licD family HPG92_RS13970 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPG92_RS13975 ENOG4105G1A colanic acid biosynthesis protein HPG92_RS13980 ENOG4107T8Q Glycosyl transferase (Group 1 HPG92_RS13985 ENOG4105C74 pyruvyl transferase HPG92_RS13990 ENOG4105PSV Polysaccharide Biosynthesis Protein HPG92_RS13995 ENOG4105D3Q Sugar transferase HPG92_RS14000 ENOG4107QKV phosphomannomutase HPG92_RS14005 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HPG92_RS14010 ENOG4106CD9 glycosyl transferase group 1 HPG92_RS14015 ENOG4105FGF GDP-mannose mannosyl hydrolase HPG92_RS14020 ENOG4105C30 Nad-dependent epimerase dehydratase HPG92_RS14025 ENOG4105C0K Gdp-mannose 4,6-dehydratase HPG92_RS14030 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HPG92_RS14035 ENOG4105ECJ Glycosyl Transferase HPG92_RS14040 ENOG4108NYJ Colanic acid HPG92_RS14045 ENOG4107RXY Glycosyl transferase HPG92_RS14050 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HPG92_RS14055 ENOG41090RK glycosyl transferase HPG92_RS14060 ENOG4105D75 Capsular exopolysaccharide family HPG92_RS14065 ENOG4105KJF protein tyrosine phosphatase HPG92_RS14070 ENOG4105DAY polysaccharide export protein HPG92_RS14075 ENOG4105EE5 Membrane protein terC HPG92_RS14080 ENOG4108GAE asmA family HPG92_RS14085 ENOG4105DHP deoxycytidine triphosphate deaminase HPG92_RS14095 ENOG4105BZU Histidine kinase HPG92_RS14100 ENOG4105D03 DNA-3-methyladenine glycosylase II HPG92_RS14105 ENOG4105R8A Heat shock protein HPG92_RS14135 ENOG4105EB3 Histidine kinase HPG92_RS14140 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPG92_RS14145 ENOG4105CFP Peptidase U32 HPG92_RS14150 ENOG41090V3 Tir chaperone protein (CesT) family HPG92_RS14160 ENOG4105EIE fructose-bisphosphate aldolase HPG92_RS14165 ENOG4105EAA nucleoside HPG92_RS14170 ENOG4108KD5 ADP-ribosylation crystallin J1 HPG92_RS14175 ENOG4108TFM Kinase, PfkB family HPG92_RS14180 ENOG4105FDP GntR family transcriptional regulator HPG92_RS14185 ENOG4105DWF phosphomethylpyrimidine kinase HPG92_RS14195 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HPG92_RS14205 ENOG4105CW0 outer membrane usher protein HPG92_RS14210 ENOG4108MQF Chaperone HPG92_RS14215 ENOG41063W2 Fimbrial protein HPG92_RS14225 ENOG4105D1F ATP-binding protein HPG92_RS14230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HPG92_RS14235 ENOG4108YCW (LipO)protein HPG92_RS14240 ENOG4108W15 Protein of unknown function (DUF1456) HPG92_RS14245 ENOG4108NEV two component transcriptional regulator, LytTR family HPG92_RS14250 ENOG4108HRK Histidine kinase HPG92_RS14265 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HPG92_RS14270 ENOG4108IJ8 ABC transporter HPG92_RS14275 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HPG92_RS14280 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HPG92_RS14285 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HPG92_RS14290 ENOG4105CXG d-lactate dehydrogenase HPG92_RS14295 ENOG41061WM D-Alanyl-D-Alanine HPG92_RS14300 ENOG41069YE inner membrane protein yohC HPG92_RS14305 ENOG4105KHU inner membrane protein YohD HPG92_RS14310 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HPG92_RS14315 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPG92_RS14325 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HPG92_RS14330 ENOG4105MSY salicylate hydroxylase HPG92_RS14335 ENOG4108RXX maleylacetoacetate isomerase HPG92_RS14365 ENOG41067MG lrgb family HPG92_RS14375 ENOG4107GZ4 SanA protein HPG92_RS14380 ENOG4105Y9N Membrane HPG92_RS14385 ENOG4105BZ8 glutamate synthase HPG92_RS14390 ENOG4107SJI Dehydrogenase HPG92_RS14395 ENOG4107SDZ Galactoside transport system permease protein mglC HPG92_RS14405 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HPG92_RS14410 ENOG41060NJ transcriptional regulator HPG92_RS14415 ENOG4105DHF Membrane HPG92_RS14420 ENOG4105EUJ GTP cyclohydrolase i HPG92_RS14435 ENOG4105D05 Receptor HPG92_RS14440 ENOG4108IQI permease HPG92_RS14445 ENOG4105DUM transcriptional regulator, lysR family HPG92_RS14450 ENOG4105HMI Membrane HPG92_RS14460 ENOG4105DM4 PTS System HPG92_RS14465 ENOG4105DE4 1-phosphofructokinase HPG92_RS14470 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HPG92_RS14475 ENOG4105S8Q sugar efflux transporter HPG92_RS14490 ENOG4105KRS Proteinase inhibitor HPG92_RS14495 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HPG92_RS14500 ENOG4105CKI cobalamin synthesis protein HPG92_RS14505 ENOG41076MN Phosphoesterase, PA-phosphatase related HPG92_RS14510 ENOG4107TT5 NLP P60 protein HPG92_RS14515 ENOG4105CXC rtn protein HPG92_RS14520 ENOG4105E43 Extracellular solute-binding protein, family 5 HPG92_RS14525 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HPG92_RS14530 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HPG92_RS14535 ENOG4108JQ5 ABC transporter HPG92_RS14540 ENOG4105HG6 HPG92_RS14545 ENOG4105C2C drug resistance transporter, Bcr CflA HPG92_RS14550 ENOG4105I08 Pseudouridine synthase HPG92_RS14555 ENOG4105CFI type iii restriction protein res subunit HPG92_RS14575 ENOG4105E68 Sulfatase HPG92_RS14625 ENOG4105WH1 Two component transcriptional regulator luxr family HPG92_RS14630 ENOG4105KWW Biogenesis protein HPG92_RS14635 ENOG4107QX9 Thiol disulfide interChange protein HPG92_RS14640 ENOG4105DA4 cytochrome c-type biogenesis protein HPG92_RS14645 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HPG92_RS14650 ENOG4105X3C heme exporter protein HPG92_RS14655 ENOG41060IM Heme exporter protein HPG92_RS14660 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPG92_RS14665 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPG92_RS14670 ENOG4105CUW cytochrome C-TYPE protein HPG92_RS14675 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HPG92_RS14680 ENOG4105GXZ Ferredoxin-type protein NapH HPG92_RS14685 ENOG4108BGM Quinol dehydrogenase periplasmic component HPG92_RS14695 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HPG92_RS14700 ENOG4108ZNS ferredoxin-type protein NapF HPG92_RS14710 ENOG4105IBP Cyclic peptide transporter HPG92_RS14715 ENOG4105CF1 Alkylated DNA repair protein HPG92_RS14720 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPG92_RS14725 ENOG4105CJ2 (LipO)protein HPG92_RS14730 ENOG4105FCK Membrane HPG92_RS14735 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HPG92_RS14740 ENOG41068CG regulatoR HPG92_RS14745 ENOG4105BZU Histidine kinase HPG92_RS14750 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPG92_RS14755 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HPG92_RS14760 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPG92_RS14765 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPG92_RS14770 ENOG4105XPH Ferredoxin HPG92_RS14775 ENOG4105CZM Major Facilitator HPG92_RS14780 ENOG4105GZI Transcriptional regulator HPG92_RS14785 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HPG92_RS14790 ENOG4105CXY transporter HPG92_RS14795 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HPG92_RS14805 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPG92_RS14815 ENOG4108EWA cinA-like protein HPG92_RS14820 ENOG4108UII YfaZ family HPG92_RS14870 ENOG4106GZG polymyxin resistance protein B HPG92_RS14875 ENOG4105CEY Amp-dependent synthetase and ligase HPG92_RS14885 ENOG4108IPT Naphthoate synthase HPG92_RS14900 ENOG4105E4F Isochorismate synthase HPG92_RS14905 ENOG4105TNS Conserved Protein HPG92_RS14910 ENOG4107YB6 acetyltransferase, (GNAT) family HPG92_RS14930 ENOG4105C8S subunit m HPG92_RS14935 ENOG4105D65 subunit l HPG92_RS14945 ENOG4107UFS subunit j HPG92_RS14955 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HPG92_RS14960 ENOG4108IEH NADH dehydrogenase subunit g HPG92_RS14965 ENOG4107QIZ NADH dehydrogenase HPG92_RS14970 ENOG4105GKE subunit e HPG92_RS14980 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPG92_RS14985 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPG92_RS14995 ENOG4107NQ8 LysR family Transcriptional regulator HPG92_RS15000 ENOG4105CHM Aminotransferase HPG92_RS15010 ENOG4107QWE )-transporter HPG92_RS15015 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HPG92_RS15030 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPG92_RS15035 ENOG4105C6K Malic enzyme HPG92_RS15040 ENOG4105CSX c4-dicarboxylate anaerobic carrier HPG92_RS15045 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HPG92_RS15050 ENOG4108HHA Transketolase HPG92_RS15055 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HPG92_RS15065 ENOG4106ETB IIa component HPG92_RS15070 ENOG4105K2J Transcriptional regulator HPG92_RS15075 ENOG4105PTV Nudix Hydrolase HPG92_RS15080 ENOG4108RE9 Phosphodiesterase HPG92_RS15085 ENOG4108SHQ Glutathione S-transferase HPG92_RS15105 ENOG4105ECP epimerase HPG92_RS15110 ENOG4108JEH abc transporter atp-binding protein HPG92_RS15115 ENOG4106YG3 ABC transporter HPG92_RS15120 ENOG4105DSP amino acid AbC transporter HPG92_RS15125 ENOG4105E89 ABC transporter HPG92_RS15130 ENOG4105E89 ABC transporter HPG92_RS15135 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPG92_RS15140 ENOG4108IQI permease HPG92_RS15145 ENOG4106M28 alanine racemase domain protein HPG92_RS15150 ENOG4105E5D amino acid HPG92_RS15160 ENOG4108JUB Transcriptional regulator HPG92_RS15165 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HPG92_RS15170 ENOG4105E96 Colicin v production protein HPG92_RS15175 ENOG4108S3P Sporulation domain protein HPG92_RS15180 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPG92_RS15190 ENOG4105DQR SNARE associated Golgi HPG92_RS15200 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPG92_RS15210 ENOG4106WZ1 flagella biosynthesis regulator HPG92_RS15225 ENOG4105R8V Transcriptional regulator HPG92_RS15240 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPG92_RS15245 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HPG92_RS15250 ENOG4105MH2 YfcL protein HPG92_RS15255 ENOG4108BPE -transporting atpase HPG92_RS15260 ENOG4105EJ9 Membrane HPG92_RS15275 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HPG92_RS15285 ENOG4108BY2 phosphohistidine phosphatase HPG92_RS15300 ENOG4105KZW UPF0381 protein HPG92_RS15310 ENOG410903C (LipO)protein HPG92_RS15315 ENOG4105S64 Formate nitrite transporter HPG92_RS15335 ENOG4108NC2 Outer membrane protease HPG92_RS15340 ENOG4105W9M Membrane HPG92_RS15345 ENOG4105D1S lipid A biosynthesis HPG92_RS15355 ENOG4108RS6 transposase HPG92_RS15360 ENOG4105CHM Aminotransferase HPG92_RS15370 ENOG4105VCT ion-transport protein YfeO HPG92_RS15380 ENOG4105CPC Aldo Keto reductase HPG92_RS15385 ENOG4109076 Conserved Protein HPG92_RS15395 ENOG4105D9N nucleoside HPG92_RS15415 ENOG4105HZG regulatoR HPG92_RS15420 ENOG4105GXM Putative transcription regulator (DUF1323) HPG92_RS15450 ENOG4108M0I Transcriptional regulator HPG92_RS15455 ENOG4105DHU Bile acid HPG92_RS15460 ENOG4105VRT cytoplasmic protein HPG92_RS15480 ENOG4105C6T cysteine synthase HPG92_RS15490 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPG92_RS15495 ENOG4105C5Y PTS System HPG92_RS15505 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HPG92_RS15510 ENOG4105CSW GntR family transcriptional regulator HPG92_RS15515 ENOG41089BK Glutamine amido-transferase HPG92_RS15520 ENOG4105C6T cysteine synthase HPG92_RS15525 ENOG4108IJ6 ABC transporter HPG92_RS15530 ENOG4105ECW sulfate abc transporter HPG92_RS15535 ENOG4108I5D sulfate abc transporter HPG92_RS15540 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HPG92_RS15545 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HPG92_RS15550 ENOG4105EZR dyp-type peroxidase family protein HPG92_RS15555 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPG92_RS15655 ENOG4105ED4 portal protein HPG92_RS15700 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HPG92_RS15735 ENOG410685N tail fiber protein HPG92_RS15740 ENOG4105UZW Tail fiber assembly protein HPG92_RS15795 ENOG4105E7K (LipO)protein HPG92_RS15800 ENOG4105QZU Inner membrane protein YfeZ HPG92_RS15805 ENOG4108R6G acetyltransferase HPG92_RS15810 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HPG92_RS15825 ENOG4105C4X radical SAM domain protein HPG92_RS15830 ENOG4105ENH Sulfatase HPG92_RS15835 ENOG4105C6K Malic enzyme HPG92_RS15845 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPG92_RS15855 ENOG4108PVD exported protein HPG92_RS15870 ENOG4105BZ8 glutamate synthase HPG92_RS15875 ENOG4105BZU Histidine kinase HPG92_RS15880 ENOG4105BZS acriflavin resistance protein HPG92_RS15890 ENOG4105KUZ arsenate reductase HPG92_RS15895 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HPG92_RS15905 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HPG92_RS15910 ENOG4105CGZ zinc metallopeptidase HPG92_RS15920 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPG92_RS15925 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPG92_RS15930 ENOG4105RH4 Glycine cleavage system transcriptional repressor HPG92_RS15935 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPG92_RS15940 ENOG4105BZW Glycerate kinase HPG92_RS15950 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HPG92_RS15955 ENOG4105C02 permease HPG92_RS15960 ENOG4105ERG peptidase m48, ste24p HPG92_RS15965 ENOG4105K89 arsenate reductase HPG92_RS15970 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HPG92_RS15975 ENOG4105C2W permease HPG92_RS15980 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HPG92_RS15990 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPG92_RS15995 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HPG92_RS16000 ENOG4105C9X ppx gppa phosphatase HPG92_RS16005 ENOG4105BZU Histidine kinase HPG92_RS16015 ENOG41062G3 Protein of unknown function (DUF2633) HPG92_RS16025 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPG92_RS16030 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPG92_RS16035 ENOG4105D4Y metalloprotease HPG92_RS16045 ENOG4105VPD cellular component movement HPG92_RS16055 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPG92_RS16060 ENOG4105N21 Membrane HPG92_RS16080 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HPG92_RS16085 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HPG92_RS16100 ENOG4105QAX Iron-sulfur HPG92_RS16105 ENOG4107QY8 reductase HPG92_RS16110 ENOG4108JQB penicillin-binding protein 1C HPG92_RS16115 ENOG4105DN3 alpha-2-macroglobulin domain protein HPG92_RS16120 ENOG4105KHC sulfurtransferase HPG92_RS16125 ENOG4105YYA enhanced serine sensitivity protein SseB HPG92_RS16135 ENOG4105WVQ Fe-S assembly protein IscX HPG92_RS16140 ENOG4108ZIT Ferredoxin, 2FE-2S HPG92_RS16145 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HPG92_RS16150 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HPG92_RS16155 ENOG4108Z4V iron-sulfur cluster assembly HPG92_RS16160 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HPG92_RS16165 ENOG4105C3J Cysteine desulfurase HPG92_RS16175 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HPG92_RS16180 ENOG4105ECY inositol monophosphatase HPG92_RS16185 ENOG4105D5B Sulfite reductase, subunit A HPG92_RS16190 ENOG4107SHJ sulfite reductase subunit b HPG92_RS16195 ENOG410810Y Sulfite reductase HPG92_RS16200 ENOG4105D7X high-affinity nickel-transporter HPG92_RS16210 ENOG4108MN2 Stationary phase inducible protein CsiE HPG92_RS16215 ENOG4105D8G Major Facilitator superfamily HPG92_RS16225 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPG92_RS16230 ENOG4108M3R transcriptional activator CadC HPG92_RS16235 ENOG4105D5Q Arginine ornithine antiporter HPG92_RS16240 ENOG4105CXN decarboxylase HPG92_RS16245 ENOG4105DUX Transporter HPG92_RS16255 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPG92_RS16260 ENOG4108SKK alpha helix protein HPG92_RS16265 ENOG4107WP9 Histidine kinase HPG92_RS16270 ENOG4108ETH Formylglycinamide ribotide synthetase HPG92_RS16280 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HPG92_RS16285 ENOG4108Z6B deaminase HPG92_RS16290 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HPG92_RS16305 ENOG4106G6Q Transcriptional regulator HPG92_RS16310 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HPG92_RS16340 ENOG4105C3F Signal peptidase i HPG92_RS16350 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HPG92_RS16375 ENOG4108IYU L-aspartate oxidase HPG92_RS16385 ENOG4105C1J atp-dependent rna helicase HPG92_RS16390 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HPG92_RS16400 ENOG4105EIB trna rrna methyltransferase HPG92_RS16405 ENOG4105K63 Thioredoxin HPG92_RS16410 ENOG4106IUH DTW domain containing protein HPG92_RS16415 ENOG4105CD5 CoA-binding domain protein HPG92_RS16420 ENOG4105JIM Phosphatidylserine synthase HPG92_RS16425 ENOG4105T42 (LipO)protein HPG92_RS16430 ENOG4105CSH Transporter HPG92_RS16460 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPG92_RS16465 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPG92_RS16470 ENOG4105C34 Pseudouridine synthase HPG92_RS16475 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPG92_RS16480 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HPG92_RS16490 ENOG4105CQC Prephenate dehydratase HPG92_RS16500 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HPG92_RS16505 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPG92_RS16510 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HPG92_RS16530 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HPG92_RS16535 ENOG4106KVJ cytochrome C assembly protein HPG92_RS16540 ENOG4108JU6 CBS domain protein HPG92_RS16555 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPG92_RS16560 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPG92_RS16595 ENOG4105Y50 Virulence Protein HPG92_RS16600 ENOG4108TMH cytolethal distending toxin HPG92_RS16665 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HPG92_RS16670 ENOG4105UZW Tail fiber assembly protein HPG92_RS16680 ENOG4105BZ1 (ABC) transporter HPG92_RS16690 ENOG4105NIV Esterase HPG92_RS16695 ENOG4107RNH Outer membrane receptor FepA HPG92_RS16700 ENOG4105VRE Pentapeptide repeat protein HPG92_RS16705 ENOG4108MJ5 VirK protein HPG92_RS16715 ENOG4105DHQ Histidine kinase HPG92_RS16745 ENOG4105D5U fad dependent oxidoreductase HPG92_RS16750 ENOG4105C26 Dehydrogenase HPG92_RS16755 ENOG4108JPW Aminotransferase HPG92_RS16760 ENOG4105C85 amino acid HPG92_RS16765 ENOG4108PVQ transcriptional regulator HPG92_RS16770 ENOG4109066 lysm domain bon superfamily protein HPG92_RS16775 ENOG4105VPI YqaE family transport protein HPG92_RS16780 ENOG41080HT Transcriptional regulator, arsr family HPG92_RS16785 ENOG4108V62 Rhodanese domain protein HPG92_RS16795 ENOG4108X73 DNA- binding protein HPG92_RS16800 ENOG4108RNS Exports L-alanine (By similarity) HPG92_RS16805 ENOG4108WMJ Protein of unknown function (DUF2002) HPG92_RS16810 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HPG92_RS16815 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HPG92_RS16825 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPG92_RS16835 ENOG4108IJ7 Glycine betaine HPG92_RS16840 ENOG4108HQS Glycine betaine HPG92_RS16845 ENOG4105GIJ Glycine betaine HPG92_RS16855 ENOG4105NTK Transcriptional repressor Mpra HPG92_RS16860 ENOG4105CW7 secretion protein, HlyD family HPG92_RS16865 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG92_RS16870 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HPG92_RS16875 ENOG4105D9M gamma-glutamylcysteine synthetase HPG92_RS16880 ENOG4105W39 Membrane HPG92_RS16885 ENOG4107VXZ Hydrolase HPG92_RS16915 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HPG92_RS16920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPG92_RS16935 ENOG4107TH8 cina domain protein HPG92_RS16940 ENOG4105CVE Lytic murein transglycosylase HPG92_RS16945 ENOG410787A Pts system, glucitol sorbitol-specific HPG92_RS16950 ENOG4105DZY Pts system, glucitol sorbitol-specific HPG92_RS16955 ENOG4105VI0 Pts system, glucitol sorbitol-specific HPG92_RS16960 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HPG92_RS16965 ENOG4105J92 DNA-binding transcriptional activator GutM HPG92_RS16970 ENOG410804X Transcriptional regulator HPG92_RS16975 ENOG4105C2X Arabinose 5-phosphate isomerase HPG92_RS16995 ENOG4105C8H hydrogenase maturation protein Hypf HPG92_RS17000 ENOG4108RC0 Electron transport protein HPG92_RS17005 ENOG4108MG9 hydrogenase 3 maturation protease HPG92_RS17010 ENOG4105I6X formate hydrogenlyase maturation HPG92_RS17015 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HPG92_RS17020 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HPG92_RS17025 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPG92_RS17030 ENOG4107TDF Formate hydrogenlyase subunit 4 HPG92_RS17035 ENOG4107R30 NADH dehydrogenase HPG92_RS17040 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HPG92_RS17045 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HPG92_RS17050 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HPG92_RS17055 ENOG4107RSS Hydrogenase accessory protein HypB HPG92_RS17060 ENOG41083WG hydrogenase assembly chaperone HPG92_RS17065 ENOG4105CQS hydrogenase expression formation protein HypD HPG92_RS17070 ENOG4105C45 hydrogenase expression formation protein (HypE) HPG92_RS17080 ENOG4105VXR cytoplasmic protein HPG92_RS17090 ENOG4105DIK (ABC) transporter HPG92_RS17095 ENOG4105CC5 ABC transporter HPG92_RS17100 ENOG4105CC5 ABC transporter HPG92_RS17130 ENOG4108RBT type iii secretion HPG92_RS17135 ENOG4106BTR HPG92_RS17140 ENOG4105Y7Q type iii secretion HPG92_RS17145 ENOG4108RC9 Type III secretion system protein HPG92_RS17155 ENOG4108YAB Invasion protein HPG92_RS17160 ENOG4105FTC Lytic transglycosylase catalytic HPG92_RS17165 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear HPG92_RS17180 ENOG41079WB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPG92_RS17190 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HPG92_RS17200 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE HPG92_RS17210 ENOG4108M6W surface presentation of antigens protein SpaS HPG92_RS17215 ENOG4108TN6 type iii secretion HPG92_RS17220 ENOG4105U07 type iii secretion HPG92_RS17225 ENOG41075IY surface presentation of antigens protein SpaP HPG92_RS17230 ENOG4105T85 surface presentation of antigens protein HPG92_RS17235 ENOG41078G4 surface presentation of HPG92_RS17240 ENOG41077MC Secretory protein (Associated with virulence) HPG92_RS17245 ENOG4108JIR Flagellum-specific ATP synthase HPG92_RS17250 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone HPG92_RS17255 ENOG4108HR8 type iii secretion HPG92_RS17260 ENOG4108N8R Invasion protein HPG92_RS17270 ENOG41090HZ type iii secretion HPG92_RS17325 ENOG4108FPN Integrase HPG92_RS17365 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG92_RS17370 ENOG4105JQN Transcriptional regulator HPG92_RS17375 ENOG4105C6Z Gluconate HPG92_RS17380 ENOG4105EXW epimerase dehydratase HPG92_RS17385 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPG92_RS17395 ENOG4105G63 Type III effector Hrp-dependent HPG92_RS17405 ENOG4105MVE transcriptional regulator HPG92_RS17415 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPG92_RS17420 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPG92_RS17425 ENOG4105KZM cytoplasmic protein HPG92_RS17440 ENOG4108K5P (LipO)protein HPG92_RS17475 ENOG4105N0Z inner membrane protein ygbE HPG92_RS17495 ENOG4108MXK alkaline phosphatase isozyme conversion HPG92_RS17505 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HPG92_RS17515 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HPG92_RS17520 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HPG92_RS17525 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HPG92_RS17530 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPG92_RS17535 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HPG92_RS17545 ENOG4105DXN mazG family HPG92_RS17550 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPG92_RS17555 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPG92_RS17560 ENOG4105BZU Histidine kinase HPG92_RS17570 ENOG4105QDK Flavodoxin HPG92_RS17575 ENOG4105DR9 pseudouridine synthase HPG92_RS17580 ENOG4105WP7 tRNA pseudouridine synthase C HPG92_RS17595 ENOG4105EWT decarboxylase family HPG92_RS17600 ENOG4105C44 Serine transporter HPG92_RS17605 ENOG4105EJQ L-serine dehydratase HPG92_RS17615 ENOG4105C0A alcohol dehydrogenase HPG92_RS17620 ENOG4107W7X Aldolase HPG92_RS17625 ENOG4105EDR glucose galactose transporter HPG92_RS17635 ENOG4105CMG Carbohydrate kinase HPG92_RS17645 ENOG4107EDW L-fucose operon activator HPG92_RS17655 ENOG4105M08 Membrane HPG92_RS17660 ENOG4105ETT transcriptional Regulator, LysR family HPG92_RS17665 ENOG4105M5B (LipO)protein HPG92_RS17670 ENOG4105C9B Cysteine desulfurase HPG92_RS17675 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HPG92_RS17685 ENOG4105CUZ uba thif-type nad fad binding protein HPG92_RS17690 ENOG4105CA3 membrane-bound lytic murein transglycosylase HPG92_RS17705 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPG92_RS17710 ENOG4108EKC n-acetylglutamate synthase HPG92_RS17715 ENOG4107QYX exodeoxyribonuclease v alpha HPG92_RS17720 ENOG4107QKA exodeoxyribonuclease V beta HPG92_RS17725 ENOG4107QXK peptidase HPG92_RS17730 ENOG4105DSY exodeoxyribonuclease V, gamma HPG92_RS17735 ENOG4105RVB Prepilin peptidase dependent protein c HPG92_RS17740 ENOG4105SEN Protein of unknown function (DUF2509) HPG92_RS17745 ENOG4105JCS prepilin peptidase dependent protein HPG92_RS17750 ENOG4105IPU prepilin peptidase dependent protein A HPG92_RS17765 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HPG92_RS17770 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HPG92_RS17780 ENOG4105EE5 Membrane protein terC HPG92_RS17785 ENOG4105SUV lipoprotein YgdR HPG92_RS17790 ENOG4105CPC Aldo Keto reductase HPG92_RS17810 ENOG4105DDV Transcriptional regulator (LacI family HPG92_RS17820 ENOG4105RQF LysR family Transcriptional regulator HPG92_RS17830 ENOG4107QNK )-transporter HPG92_RS17835 ENOG4105CHR reductase HPG92_RS17845 ENOG4105CHU acetyl-coa acetyltransferase HPG92_RS17850 ENOG4105C5Q Transcriptional regulator HPG92_RS17860 ENOG4108MHD transport protein HPG92_RS17870 ENOG4108MGN ATP-binding component of a transport system HPG92_RS17965 ENOG4105XB7 anti-repressor protein HPG92_RS17985 ENOG4105DFP Integrase HPG92_RS17995 ENOG4108K5P (LipO)protein HPG92_RS18000 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HPG92_RS18015 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPG92_RS18020 ENOG4105T95 Thiol disulfide interChange protein HPG92_RS18025 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPG92_RS18030 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HPG92_RS18035 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HPG92_RS18040 ENOG4105Y75 tpr repeat protein HPG92_RS18050 ENOG4108UT2 hemolysin iii HPG92_RS18060 ENOG4105CS2 ec 3.2.1.21 HPG92_RS18065 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HPG92_RS18080 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPG92_RS18085 ENOG4105D0A hydroxylase HPG92_RS18090 ENOG4107RAQ aminopeptidase HPG92_RS18110 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPG92_RS18115 ENOG4108JQ1 Dehydrogenase HPG92_RS18120 ENOG4105E66 phosphoriboisomerase A HPG92_RS18130 ENOG4105MPN Membrane HPG92_RS18140 ENOG4105D64 Mechanosensitive ion channel HPG92_RS18145 ENOG4105D2N Aldolase HPG92_RS18150 ENOG4105BZA Phosphoglycerate kinase HPG92_RS18175 ENOG4108JJB ABC transporter HPG92_RS18180 ENOG4108JJB ABC transporter HPG92_RS18185 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPG92_RS18190 ENOG4108K0D peptidase, M48 HPG92_RS18200 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HPG92_RS18225 ENOG4107QNK )-transporter HPG92_RS18230 ENOG4105GPY SprT protein HPG92_RS18235 ENOG4105RWS endonuclease I HPG92_RS18240 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPG92_RS18245 ENOG4105D7Z glutathione synthase HPG92_RS18265 ENOG4105CZX twitching motility protein HPG92_RS18270 ENOG4105DFA alanine racemase domain protein HPG92_RS18275 ENOG4108VIA integral membrane protein HPG92_RS18290 ENOG4105CSA Coproporphyrinogen iii oxidase HPG92_RS18295 ENOG4105HDK L-asparaginase HPG92_RS18300 ENOG4105K33 Periplasmic Protein HPG92_RS18305 ENOG41090ED Protein with unknown function (DUF469) HPG92_RS18315 ENOG4105CEN a g-specific adenine glycosylase HPG92_RS18320 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HPG92_RS18335 ENOG4105CXN decarboxylase HPG92_RS18340 ENOG4108UQV Membrane HPG92_RS18375 ENOG4105EFV Major head subunit HPG92_RS18455 ENOG4108IQE Amp-dependent synthetase and ligase HPG92_RS18465 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HPG92_RS18495 ENOG4105C1G acyl-Coa dehydrogenase HPG92_RS18510 ENOG4105CR4 methylisocitrate lyase HPG92_RS18530 ENOG4105DND Transcriptional regulator HPG92_RS18605 ENOG4107STF Involved in phosphonate degradation (By similarity) HPG92_RS18615 ENOG4105C87 Aminotransferase class I and II HPG92_RS18620 ENOG4105DTI Phosphonopyruvate decarboxylase HPG92_RS18630 ENOG4105E5W Transporter HPG92_RS18635 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPG92_RS18665 ENOG4108WN0 inhibitor of vertebrate lysozyme HPG92_RS18710 ENOG4105DJG MaoC domain protein dehydratase HPG92_RS18725 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HPG92_RS18735 ENOG4108UAJ Transcriptional regulator HPG92_RS18745 ENOG4105CUB amino acid HPG92_RS18760 ENOG4105C26 Dehydrogenase HPG92_RS18780 ENOG4105DPW Major facilitator superfamily MFS_1 HPG92_RS18790 ENOG4105DEI Mannitol dehydrogenase HPG92_RS18805 ENOG4106032 Glutathionylspermidine synthase HPG92_RS18810 ENOG4105CYM Glutathione S-transferase HPG92_RS18815 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HPG92_RS18820 ENOG4105S10 periplasmic binding protein HPG92_RS18825 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HPG92_RS18830 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HPG92_RS18835 ENOG4108WGS hydrogenase 2-specific chaperone HPG92_RS18840 ENOG4108USZ hydrogenase HPG92_RS18845 ENOG4105DPX Hydrogenase, large subunit HPG92_RS18850 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HPG92_RS18855 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPG92_RS18860 ENOG4105E3S small subunit HPG92_RS18865 ENOG410900S Protein of unknown function (DUF2623) HPG92_RS18870 ENOG4105C8Q Methyl-accepting chemotaxis HPG92_RS18895 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPG92_RS18900 ENOG4108ZZF transport protein (ExbD) HPG92_RS18905 ENOG4105CWK Biopolymer transport protein, ExbB HPG92_RS18910 ENOG4105C28 cystathionine HPG92_RS18915 ENOG4108K81 inner membrane protein YghB HPG92_RS18920 ENOG4105CF7 AraC family transcriptional regulator HPG92_RS18925 ENOG4108I6A alcohol dehydrogenase HPG92_RS18930 ENOG4105CV8 reductase HPG92_RS18935 ENOG4107QPK )-transporter HPG92_RS18945 ENOG4105CCT upf0313 protein HPG92_RS18950 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HPG92_RS18955 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HPG92_RS18960 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPG92_RS18965 ENOG4105GMB type VI secretion system effector, hcp1 family HPG92_RS18975 ENOG4105H4F exported protein HPG92_RS18980 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPG92_RS18985 ENOG4105DHQ Histidine kinase HPG92_RS18990 ENOG4105NF4 modulator of drug activity HPG92_RS18995 ENOG4105VRH Antibiotic biosynthesis monooxygenase HPG92_RS19000 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPG92_RS19005 ENOG4105IPS esterase HPG92_RS19010 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPG92_RS19015 ENOG4108SX3 cytoplasmic protein HPG92_RS19020 ENOG41087AY ADP-Ribose pyrophosphatase HPG92_RS19030 ENOG4105F1G UPF0441 protein HPG92_RS19035 ENOG4106032 Glutathionylspermidine synthase HPG92_RS19040 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HPG92_RS19050 ENOG4108MR7 Arylsulfotransferase HPG92_RS19060 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) HPG92_RS19070 ENOG4105W0Z cytoplasmic protein HPG92_RS19090 ENOG4105I7R Adenylate cyclase HPG92_RS19095 ENOG4106MWK domain protein HPG92_RS19110 ENOG4107ZVW dihydroneopterin aldolase HPG92_RS19135 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPG92_RS19140 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG92_RS19155 ENOG4108VCA G U mismatch-specific DNA glycosylase HPG92_RS19165 ENOG4105ZTC transcriptional activator, Ogr delta HPG92_RS19205 ENOG4108C33 Resolvase HPG92_RS19220 ENOG4105PTU response to oxidative stress HPG92_RS19230 ENOG4105PTU response to oxidative stress HPG92_RS19320 ENOG4105ED4 portal protein HPG92_RS19355 ENOG4105DFE Dna adenine methylase HPG92_RS19370 ENOG4105KSC Transcriptional regulator, TraR DksA family HPG92_RS19410 ENOG4108KU3 Integrase HPG92_RS19420 ENOG4105Q26 Siderophore-interacting protein HPG92_RS19425 ENOG4105NTW Transcriptional regulator HPG92_RS19430 ENOG4105C8Q Methyl-accepting chemotaxis HPG92_RS19435 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HPG92_RS19450 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPG92_RS19460 ENOG4108VKG metal-dependent hydrolase HPG92_RS19470 ENOG4105EE0 oxidoreductase HPG92_RS19475 ENOG4105DU1 integral membrane protein, terc HPG92_RS19485 ENOG4105CTX dehydratase HPG92_RS19495 ENOG4105DPW Major facilitator superfamily MFS_1 HPG92_RS19500 ENOG4107YCY Transcriptional regulator HPG92_RS19505 ENOG4106W5V Membrane HPG92_RS19515 ENOG4105WAY exported protein HPG92_RS19520 ENOG4105NE1 Conserved Protein HPG92_RS19525 ENOG41090KG Inner membrane protein YqjE HPG92_RS19530 ENOG4105YJD HPG92_RS19535 ENOG4108VBZ doxx family HPG92_RS19540 ENOG4105CHF Glutathione S-transferase HPG92_RS19545 ENOG4105KAF membrAne HPG92_RS19550 ENOG4105CWB LysR family transcriptional Regulator HPG92_RS19555 ENOG4108CNN domain protein HPG92_RS19560 ENOG4106D80 Uncharacterized protein YhaL HPG92_RS19570 ENOG4105C44 Serine transporter HPG92_RS19575 ENOG4105EJQ L-serine dehydratase HPG92_RS19580 ENOG4105C6N Formate acetyltransferase HPG92_RS19590 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HPG92_RS19595 ENOG4105C7B Threonine dehydratase HPG92_RS19600 ENOG410811B TRANSCRIPTIONal HPG92_RS19615 ENOG4105E98 transcriptional regulator DeoR family HPG92_RS19620 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HPG92_RS19625 ENOG4105CE4 GlcNAc 6-P deacetylase HPG92_RS19630 ENOG4105E70 isomerase HPG92_RS19635 ENOG4105D2N Aldolase HPG92_RS19640 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPG92_RS19660 ENOG4105W4M Transport-associated protein HPG92_RS19665 ENOG4105K4T epimerase HPG92_RS19670 ENOG4107R7Y intracellular protease Pfpi family HPG92_RS19685 ENOG4108YYD acetyltransferase HPG92_RS19705 ENOG4105DEN Luciferase family HPG92_RS19710 ENOG4105CIC tryptophan-specific transport protein HPG92_RS19715 ENOG4105C1J atp-dependent rna helicase HPG92_RS19745 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HPG92_RS19750 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HPG92_RS19755 ENOG4105CHV Transcription elongation factor NusA HPG92_RS19760 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HPG92_RS19770 ENOG4105CDH Citrulline--aspartate ligase HPG92_RS19780 ENOG4105NTZ Preprotein translocase subunit SecG HPG92_RS19785 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HPG92_RS19790 ENOG4105EEI dihydropteroate synthase HPG92_RS19795 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPG92_RS19805 ENOG4105HBR Rna-binding protein HPG92_RS19810 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HPG92_RS19815 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HPG92_RS19825 ENOG4105QYV Membrane HPG92_RS19830 ENOG4105K46 50S ribosomal protein l27 HPG92_RS19840 ENOG4105EAH synthase HPG92_RS19845 ENOG4105HVQ Regulatory factor of maltose metabolism HPG92_RS19855 ENOG4105VFK BolA family HPG92_RS19860 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HPG92_RS19865 ENOG4105E3I toluene tolerance HPG92_RS19870 ENOG4107PE3 Mammalian cell entry related domain protein HPG92_RS19875 ENOG4105CY3 ABC transporter, permease HPG92_RS19880 ENOG4105DHJ ABC, transporter HPG92_RS19885 ENOG4105FEU K -dependent Na -Ca exchanger HPG92_RS19890 ENOG4105C2X Arabinose 5-phosphate isomerase HPG92_RS19895 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HPG92_RS19900 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HPG92_RS19905 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HPG92_RS19910 ENOG4108IUZ ABC transporter HPG92_RS19915 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG92_RS19920 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HPG92_RS19925 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HPG92_RS19935 ENOG41080Z8 PHOSPHOCARRIER protein HPG92_RS19940 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HPG92_RS19950 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HPG92_RS19955 ENOG4105BZU Histidine kinase HPG92_RS19960 ENOG4105N5T Radical SAM Protein HPG92_RS19965 ENOG4105CBC glutamate synthase HPG92_RS19970 ENOG4105BZ8 glutamate synthase HPG92_RS19985 ENOG4105DZC cytosine deaminase HPG92_RS19990 ENOG4108R66 Conserved Protein HPG92_RS20005 ENOG4105JHE Major Facilitator Superfamily HPG92_RS20020 ENOG4105KB2 stringent starvation protein b HPG92_RS20025 ENOG4107MKT Stringent starvation protein a HPG92_RS20045 ENOG4105D6Z AFG1 family ATPase HPG92_RS20050 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HPG92_RS20055 ENOG4105C0H protease HPG92_RS20065 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HPG92_RS20075 ENOG4105RID UPF0379 protein yhcN HPG92_RS20080 ENOG4105RID UPF0379 protein yhcN HPG92_RS20085 ENOG4105UNR (Barnase) inhibitor HPG92_RS20100 ENOG4105ZQC membrane protein AaeX HPG92_RS20105 ENOG4105CR8 Transcriptional regulator HPG92_RS20115 ENOG4105D1U peptidase U62 modulator of DNA gyrase HPG92_RS20120 ENOG4105QD6 exported protein HPG92_RS20125 ENOG4105C03 ribonuclease HPG92_RS20130 ENOG4108Z03 MAF-like protein HPG92_RS20135 ENOG4105VQ7 Rod shape-determining protein MreD HPG92_RS20140 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HPG92_RS20150 ENOG41062P1 Diguanylate cyclase phosphodiesterase HPG92_RS20155 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HPG92_RS20170 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HPG92_RS20175 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPG92_RS20180 ENOG4105RG0 Membrane HPG92_RS20185 ENOG4108IA2 Sodium pantothenate symporter HPG92_RS20190 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HPG92_RS20195 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPG92_RS20205 ENOG4105CEC DNA methylase N-4 N-6 HPG92_RS20210 ENOG41061ME transport protein HPG92_RS20215 ENOG4105BZU Histidine kinase HPG92_RS20220 ENOG4108XG4 DNA-binding transcriptional regulator HPG92_RS20225 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPG92_RS20230 ENOG4105BZS acriflavin resistance protein HPG92_RS20235 ENOG4105XCM membrane LIPOPROTEIN HPG92_RS20280 ENOG4108Z0R Transferase HPG92_RS20285 ENOG4105SG3 Protein of unknown function (DUF1488) HPG92_RS20300 ENOG4108WI1 Dna topoisomerase HPG92_RS20310 ENOG4105C79 DNA protecting protein DprA HPG92_RS20330 ENOG4105C1A potassium transporter peripheral membrane HPG92_RS20335 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HPG92_RS20340 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HPG92_RS20345 ENOG4105W1Y Transcriptional regulator HPG92_RS20350 ENOG4105VTS DnaJ-like, subfamily C HPG92_RS20365 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HPG92_RS20380 ENOG41067V7 50S ribosomal protein L36 HPG92_RS20385 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPG92_RS20395 ENOG4105VPB 50S ribosomal protein L30 HPG92_RS20420 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HPG92_RS20425 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HPG92_RS20430 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HPG92_RS20440 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HPG92_RS20445 ENOG41083MP 50s ribosomal protein l29 HPG92_RS20465 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HPG92_RS20495 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HPG92_RS20500 ENOG4108UQY Iron-storage protein HPG92_RS20505 ENOG4105W53 bacterioferritin-associated ferredoxin HPG92_RS20510 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPG92_RS20530 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HPG92_RS20535 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HPG92_RS20545 ENOG4105WWK YheO domain protein HPG92_RS20550 ENOG4108V1T peptidylprolyl cis-trans isomerase HPG92_RS20555 ENOG4105VRX Protein slyX homolog HPG92_RS20560 ENOG4108YZY peptidylprolyl cis-trans isomerase HPG92_RS20565 ENOG4105VKU nucleicacid-binding protein HPG92_RS20580 ENOG4105C5H ABC transporter HPG92_RS20585 ENOG4105N0V mono-oxygenase ydhR HPG92_RS20600 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HPG92_RS20605 ENOG4108UKZ OsmC family HPG92_RS20610 ENOG4107RYR Transcriptional regulator, Crp Fnr family HPG92_RS20615 ENOG410613R integral membrane protein, YccS YhfK family HPG92_RS20620 ENOG4105C8Y Acetylornithine aminotransferase HPG92_RS20625 ENOG4105DDQ anthranilate synthase HPG92_RS20630 ENOG4105MZU cell filamentation protein HPG92_RS20635 ENOG4106195 uncharacterized protein yhfG HPG92_RS20640 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HPG92_RS20650 ENOG4107QZF nitrite reductase NADPH large subunit HPG92_RS20655 ENOG4105WZK nitrite reductase NADPH small subunit HPG92_RS20660 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPG92_RS20665 ENOG4107EF2 surface-exposed virulence protein HPG92_RS20670 ENOG4105VYH HPG92_RS20675 ENOG4105C31 Tryptophanyl-tRNA synthetase HPG92_RS20685 ENOG4105DJV ribulose-phosphate 3-epimerase HPG92_RS20690 ENOG4105DFE Dna adenine methylase HPG92_RS20695 ENOG4105EGB membrane protein DamX HPG92_RS20710 ENOG4105E4G Type IV pilus HPG92_RS20715 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HPG92_RS20720 ENOG4105XPX DNA utilization protein HofO HPG92_RS20725 ENOG41065NF Fimbrial assembly family protein HPG92_RS20730 ENOG4108U1Q Pilus assembly protein HPG92_RS20735 ENOG4108JQC penicillin-binding protein 1A HPG92_RS20740 ENOG4107RK2 ADP-ribose diphosphatase NudE HPG92_RS20750 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HPG92_RS20755 ENOG4105VEJ Heat shock protein HPG92_RS20765 ENOG4108MAJ Membrane HPG92_RS20770 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HPG92_RS20775 ENOG4105E0F Histidine kinase HPG92_RS20785 ENOG4108RRZ Transcription elongation factor GreB HPG92_RS20790 ENOG4105BZM domain protein HPG92_RS20795 ENOG4105XFK Ferrous iron transport protein A HPG92_RS20800 ENOG4105CE1 Ferrous iron transport protein b HPG92_RS20810 ENOG4105DNE Transposase HPG92_RS20820 ENOG4105MJ2 Competence protein HPG92_RS20830 ENOG4105C6Z Gluconate HPG92_RS20835 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HPG92_RS20840 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HPG92_RS20850 ENOG4105E98 transcriptional regulator DeoR family HPG92_RS20865 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HPG92_RS20870 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HPG92_RS20890 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPG92_RS20895 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPG92_RS20905 ENOG4105C6Z Gluconate HPG92_RS20910 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HPG92_RS20915 ENOG4105DIQ Transcriptional regulator HPG92_RS20920 ENOG4105C2I pirin domain protein HPG92_RS20925 ENOG4105D9R oxidoreductase HPG92_RS20930 ENOG4105WCN acetyltransferase HPG92_RS20935 ENOG4108RVA ribokinase HPG92_RS20950 ENOG41080QX K07048 phosphotriesterase-related protein HPG92_RS20955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPG92_RS20960 ENOG4105WC8 Conserved Protein HPG92_RS20965 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HPG92_RS20980 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HPG92_RS20985 ENOG4105BZ7 extracellular solute-binding protein family 1 HPG92_RS20990 ENOG4108IV0 ABC, transporter HPG92_RS20995 ENOG4105C0Z ABC transporter HPG92_RS21000 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPG92_RS21005 ENOG4105C32 Amino acid ABC transporter (Permease) HPG92_RS21010 ENOG4105CP9 extracellular ligand-binding receptor HPG92_RS21015 ENOG4105U59 -acetyltransferase HPG92_RS21025 ENOG4105CP9 extracellular ligand-binding receptor HPG92_RS21035 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPG92_RS21040 ENOG4105CAK Cell division ATP-binding protein ftsE HPG92_RS21045 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPG92_RS21050 ENOG4106H78 methyltransferase HPG92_RS21055 ENOG4105MG3 Membrane HPG92_RS21065 ENOG4107FS9 Membrane HPG92_RS21075 ENOG4105C8Q Methyl-accepting chemotaxis HPG92_RS21085 ENOG4105EX9 Membrane HPG92_RS21090 ENOG4108W1V Lipoprotein HPG92_RS21100 ENOG4105DSF transport protein HPG92_RS21105 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HPG92_RS21115 ENOG4105CMI transporter HPG92_RS21125 ENOG4105D0S secretion protein (HlyD HPG92_RS21130 ENOG4105CBX hi0933 family HPG92_RS21145 ENOG4108M6U Universal stress protein A HPG92_RS21150 ENOG4105DUX Transporter HPG92_RS21160 ENOG4105DGW oligopeptidase A HPG92_RS21170 ENOG4105D6S protein involved in catabolism of external DNA HPG92_RS21175 ENOG4105DC8 reductase HPG92_RS21195 ENOG4106S2D Transcriptional regulator HPG92_RS21200 ENOG4105CBN LysR family transcriptional regulator HPG92_RS21205 ENOG4107H3J ribonuclease HPG92_RS21215 ENOG41066T0 asmA family HPG92_RS21220 ENOG4105CMB EAL domain-containing protein HPG92_RS21225 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HPG92_RS21230 ENOG4105CS0 peptidase HPG92_RS21240 ENOG4105BZU Histidine kinase HPG92_RS21245 ENOG4105EJG cellulose synthase HPG92_RS21250 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HPG92_RS21255 ENOG4107EEX Cellulose synthase regulator protein HPG92_RS21260 ENOG4107QZ7 Cellulose synthase catalytic subunit HPG92_RS21265 ENOG4105UTS cellulose synthase operon protein YhjQ HPG92_RS21270 ENOG410661M cytoplasmic protein HPG92_RS21280 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HPG92_RS21285 ENOG4105D1V cellulose synthase operon protein YhjU HPG92_RS21300 ENOG4105C44 Serine transporter HPG92_RS21305 ENOG4108JQ7 (ABC) transporter HPG92_RS21310 ENOG4105C3U ABC transporter HPG92_RS21315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG92_RS21325 ENOG4105DEF Extracellular solute-binding protein, family 5 HPG92_RS21340 ENOG4105DIJ Phosphoethanolamine transferase HPG92_RS21345 ENOG4105EAX Putative lipase HPG92_RS21350 ENOG4108R3E Dna-3-methyladenine glycosylase i HPG92_RS21355 ENOG4105HNP -acetyltransferase HPG92_RS21360 ENOG4107QY8 reductase HPG92_RS21365 ENOG4108ZG0 Ompa motb domain protein HPG92_RS21375 ENOG4106JH6 (LipO)protein HPG92_RS21380 ENOG4105MVF Transcriptional regulator HPG92_RS21400 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit HPG92_RS21405 ENOG4105RGS lipoprotein ysaB HPG92_RS21410 ENOG4105MEV Acyl-transferase HPG92_RS21420 ENOG4105CMG Carbohydrate kinase HPG92_RS21430 ENOG4105T16 Transcriptional regulator (AraC family) HPG92_RS21435 ENOG4108UR8 BAX protein HPG92_RS21440 ENOG4107T9C Alpha amylase catalytic region HPG92_RS21445 ENOG4105JKW Valine--pyruvate aminotransferase HPG92_RS21455 ENOG4105J4Q Transcriptional regulator HPG92_RS21465 ENOG4108R66 Conserved Protein HPG92_RS21470 ENOG4108M5W HPG92_RS21475 ENOG4105DJB Major Facilitator Superfamily HPG92_RS21480 ENOG4105CMG Carbohydrate kinase HPG92_RS21485 ENOG4105H6Q decarboxylase HPG92_RS21490 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HPG92_RS21495 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPG92_RS21505 ENOG4105CT4 transporter HPG92_RS21515 ENOG4105C26 Dehydrogenase HPG92_RS21520 ENOG41066F8 ROK family HPG92_RS21525 ENOG4105C0A alcohol dehydrogenase HPG92_RS21530 ENOG4105EM7 Selenocysteine-specific translation elongation factor HPG92_RS21540 ENOG4108U78 Glutathione S-transferase HPG92_RS21545 ENOG4105CTS PTS system mannitol-specific HPG92_RS21555 ENOG4105E61 Mannitol repressor protein HPG92_RS21565 ENOG4108YYI Protein of unknown function (DUF2810) HPG92_RS21570 ENOG4105DAA L-lactate HPG92_RS21575 ENOG41073TP transcriptional regulator HPG92_RS21585 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HPG92_RS21590 ENOG4105D7W serine acetyltransferase HPG92_RS21595 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HPG92_RS21600 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HPG92_RS21605 ENOG4105VW4 glutaredoxin 3 HPG92_RS21610 ENOG4107YZP Rhodanese domain protein HPG92_RS21625 ENOG4105PXI polysaccharide deacetylase HPG92_RS21630 ENOG4105K64 Glycosyl transferase, family 2 HPG92_RS21635 ENOG4105CPQ Dehydrogenase HPG92_RS21640 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPG92_RS21650 ENOG4105XA0 heptosyltransferase ii HPG92_RS21655 ENOG4105D16 lipopolysaccharide heptosyltransferase i HPG92_RS21660 ENOG4108FRV O-antigen ligase HPG92_RS21665 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HPG92_RS21670 ENOG4108PDR lipopolysaccharide core biosynthesis protein HPG92_RS21675 ENOG4105X1N Glycosyl transferase family 8 HPG92_RS21680 ENOG4106AH0 Glycosyl Transferase HPG92_RS21685 ENOG4107XU6 Glycosyl transferase (Group 1 HPG92_RS21690 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide HPG92_RS21695 ENOG4107543 (lipo)polysaccharide HPG92_RS21700 ENOG4107RJ7 Glycosyl transferase (Group 1 HPG92_RS21705 ENOG4105DKP glycosyl transferase, family 9 HPG92_RS21710 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HPG92_RS21740 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPG92_RS21760 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HPG92_RS21765 ENOG4105DSJ YicC domain protein HPG92_RS21780 ENOG4105EN6 Membrane HPG92_RS21800 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPG92_RS21805 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HPG92_RS21810 ENOG4105CB5 ATP-dependent DNA helicase recG HPG92_RS21815 ENOG4105D6U Sodium Glutamate Symporter HPG92_RS21820 ENOG4105C2W permease HPG92_RS21825 ENOG4105JV1 AsmA family HPG92_RS21830 ENOG4105CJQ hydrolase, family 31 HPG92_RS21835 ENOG4105CT4 transporter HPG92_RS21845 ENOG4105CHJ isochorismatase hydrolase HPG92_RS21870 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HPG92_RS21875 ENOG4105KT7 mgtC SapB transporter HPG92_RS21880 ENOG4108UZ3 Transporter HPG92_RS21920 ENOG4105F3R pts system mannose fructose sorbose family iid HPG92_RS21925 ENOG4105ETZ PTS System HPG92_RS21930 ENOG4105DAS pts system HPG92_RS21950 ENOG4105CS2 ec 3.2.1.21 HPG92_RS21960 ENOG4108SAJ Protein of unknown function (DUF1198) HPG92_RS21965 ENOG4105CXY transporter HPG92_RS21970 ENOG4105CXY transporter HPG92_RS21975 ENOG4105BZU Histidine kinase HPG92_RS21980 ENOG4108KX4 response regulator HPG92_RS21990 ENOG4105EDR glucose galactose transporter HPG92_RS22000 ENOG4107FB0 transcriptional regulator DeoR family HPG92_RS22005 ENOG4105M71 acetolactate synthase 1 regulatory subunit HPG92_RS22010 ENOG4105C7K acetolactate synthase HPG92_RS22035 ENOG4105E5M Multidrug resistance protein D HPG92_RS22045 ENOG4105J13 transcriptional regulator HPG92_RS22050 ENOG4105JP4 Inner membrane protein yidG HPG92_RS22055 ENOG4105VG5 Membrane HPG92_RS22065 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HPG92_RS22075 ENOG4105R2A (LipO)protein HPG92_RS22080 ENOG4105D99 atp gtp-binding protein HPG92_RS22085 ENOG4105KWW Biogenesis protein HPG92_RS22090 ENOG4107QX9 Thiol disulfide interChange protein HPG92_RS22095 ENOG4105DA4 cytochrome c-type biogenesis protein HPG92_RS22100 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HPG92_RS22105 ENOG4105X3C heme exporter protein HPG92_RS22110 ENOG41060IM Heme exporter protein HPG92_RS22115 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPG92_RS22120 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPG92_RS22125 ENOG4105CA0 peroxidase HPG92_RS22135 ENOG4108EM1 reductase HPG92_RS22140 ENOG4105CUW cytochrome C-TYPE protein HPG92_RS22145 ENOG4106WF9 DNA-binding transcriptional regulator TorR HPG92_RS22150 ENOG4108SV3 Tmao reductase system periplasmic protein tort HPG92_RS22155 ENOG4105BZU Histidine kinase HPG92_RS22175 ENOG410667J hydrolase HPG92_RS22185 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HPG92_RS22220 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPG92_RS22230 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPG92_RS22240 ENOG4105VG0 50S ribosomal protein l34 HPG92_RS22275 ENOG4105E8Q phosphopantetheinyl transferase HPG92_RS22280 ENOG4108YYH Nadph-dependent fmn reductase HPG92_RS22285 ENOG4105C7N Xanthine uracil vitamin C permease HPG92_RS22290 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HPG92_RS22300 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HPG92_RS22305 ENOG4105E2Z phosphate ABC transporter (Permease HPG92_RS22310 ENOG4105C8U phosphate abc transporter HPG92_RS22315 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HPG92_RS22325 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HPG92_RS22330 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HPG92_RS22335 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HPG92_RS22355 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HPG92_RS22370 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HPG92_RS22385 ENOG4105QTB Flavodoxin HPG92_RS22390 ENOG4108VVK transcriptional Regulator, AsnC HPG92_RS22425 ENOG4105CNN ABC, transporter HPG92_RS22430 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPG92_RS22435 ENOG4108RVA ribokinase HPG92_RS22440 ENOG4105ETE Transcriptional regulator (LacI family HPG92_RS22450 ENOG4107EJG GntR family transcriptional regulator HPG92_RS22495 ENOG4105C0P Mg chelatase subunit ChlI HPG92_RS22510 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HPG92_RS22515 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPG92_RS22525 ENOG4105C7B Threonine dehydratase HPG92_RS22535 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HPG92_RS22540 ENOG4105DT3 PTS system, galactitol-specific IIc component HPG92_RS22555 ENOG4105CMT Dihydroxyacetone kinase HPG92_RS22570 ENOG4105RKW reductase (By HPG92_RS22575 ENOG4108UTZ Dihydroxyacetone kinase HPG92_RS22580 ENOG4105CMT Dihydroxyacetone kinase HPG92_RS22585 ENOG4105EMY transcriptional regulator HPG92_RS22595 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HPG92_RS22605 ENOG4107SXA Phosphorylase HPG92_RS22610 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HPG92_RS22615 ENOG4105C4R Atp-dependent dna helicase HPG92_RS22640 ENOG4105C1J atp-dependent rna helicase HPG92_RS22655 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPG92_RS22660 ENOG4105ESV Glycosyl transferase, family 4 HPG92_RS22665 ENOG4105SFE lipopolysaccharide biosynthesis protein HPG92_RS22670 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPG92_RS22675 ENOG4108IJ1 Dehydrogenase HPG92_RS22680 ENOG4105C1B dTDP-glucose 4-6-dehydratase HPG92_RS22685 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HPG92_RS22690 ENOG4108WJ1 acetyltransferase HPG92_RS22695 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPG92_RS22700 ENOG4105EGZ biosynthesis protein HPG92_RS22715 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HPG92_RS22720 ENOG4105C85 amino acid HPG92_RS22745 ENOG410601J HemY protein HPG92_RS22750 ENOG4105ECF c-methyltransferase HPG92_RS22755 ENOG41076E6 Uroporphyrinogen-III Synthase HPG92_RS22765 ENOG4107T0K Adenylate cyclase HPG92_RS22775 ENOG4105S7Z (LipO)protein HPG92_RS22785 ENOG4105CT0 Protein of unknown function, DUF484 HPG92_RS22790 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPG92_RS22795 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HPG92_RS22800 ENOG4105C4R Atp-dependent dna helicase HPG92_RS22805 ENOG4107QUT magnesium and cobalt transport protein CorA HPG92_RS22820 ENOG4105FR1 rard protein HPG92_RS22825 ENOG4108VUY thioesterase Superfamily protein HPG92_RS22830 ENOG4105HDD phospholipase HPG92_RS22835 ENOG4105C9U ATP-dependent DNA helicase RecQ HPG92_RS22840 ENOG4105CCF Lysine exporter protein (Lyse ygga) HPG92_RS22845 ENOG410829K Lysine exporter protein (Lyse ygga) HPG92_RS22850 ENOG4108EUD Lysophospholipase HPG92_RS22855 ENOG4105DQF Hydrolase HPG92_RS22860 ENOG4105EMK carboxylate amino acid amine transporter HPG92_RS22865 ENOG4105DZ2 Transcriptional regulator HPG92_RS22875 ENOG4105C4X radical SAM domain protein HPG92_RS22880 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HPG92_RS22885 ENOG4107SXA Phosphorylase HPG92_RS22890 ENOG4105CGY Dna recombination protein HPG92_RS22900 ENOG4105JC1 sterol-binding domain protein HPG92_RS22910 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HPG92_RS22915 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HPG92_RS22920 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPG92_RS22925 ENOG4105F8V Hydrolase, tatD family HPG92_RS22930 ENOG4105MDZ Transcriptional activator rfaH HPG92_RS22935 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPG92_RS22940 ENOG4107QK7 reductase HPG92_RS22945 ENOG4105CHU acetyl-coa acetyltransferase HPG92_RS22960 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HPG92_RS22970 ENOG4108RR8 protoporphyrinogen oxidase HPG92_RS23005 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HPG92_RS23010 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HPG92_RS23015 ENOG4105PC1 Conserved Protein HPG92_RS23025 ENOG4108Z33 Thiol disulfide Interchange Protein HPG92_RS23030 ENOG4106HNH Acyl-transferase HPG92_RS23035 ENOG4105C2M dna polymerase I HPG92_RS23050 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HPG92_RS23055 ENOG4105D4P Coproporphyrinogen iii oxidase HPG92_RS23060 ENOG4106FIY HPG92_RS23065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPG92_RS23070 ENOG4105CUX Signal transduction histidine kinase HPG92_RS23075 ENOG4105C5F glutamine synthetase HPG92_RS23085 ENOG4105CI3 gtp-binding protein typa HPG92_RS23095 ENOG4105CT4 transporter HPG92_RS23100 ENOG4105CT4 transporter HPG92_RS23105 ENOG4105CJQ hydrolase, family 31 HPG92_RS23110 ENOG4107WI4 Aldose-1-epimerase HPG92_RS23115 ENOG4107QKS N-acylglucosamine 2-epimerase HPG92_RS23120 ENOG4105D2M Aldolase HPG92_RS23125 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPG92_RS23135 ENOG4105E98 transcriptional regulator DeoR family HPG92_RS23140 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HPG92_RS23155 ENOG4105SUU thioesterase domain HPG92_RS23165 ENOG41068KX affects formate dehydrogenase-N HPG92_RS23180 ENOG4108MG3 formate dehydrogenase HPG92_RS23185 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein