locus-tag class description H4F89_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H4F89_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H4F89_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H4F89_RS00040 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria H4F89_RS00045 ENOG4105DPW Major facilitator superfamily MFS_1 H4F89_RS00050 ENOG410667J hydrolase H4F89_RS00055 ENOG4105EMF GntR family transcriptional regulator H4F89_RS00060 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 H4F89_RS00065 ENOG4108RTU Aldolase H4F89_RS00075 ENOG4105DJB Major Facilitator Superfamily H4F89_RS00080 ENOG4105BZU Histidine kinase H4F89_RS00085 ENOG4108SV3 Tmao reductase system periplasmic protein tort H4F89_RS00090 ENOG4106WF9 DNA-binding transcriptional regulator TorR H4F89_RS00095 ENOG4105CUW cytochrome C-TYPE protein H4F89_RS00100 ENOG4108EM1 reductase H4F89_RS00110 ENOG4105CA0 peroxidase H4F89_RS00115 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) H4F89_RS00120 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) H4F89_RS00125 ENOG41060IM Heme exporter protein H4F89_RS00130 ENOG4105X3C heme exporter protein H4F89_RS00140 ENOG4105DA4 cytochrome c-type biogenesis protein H4F89_RS00145 ENOG4107QX9 Thiol disulfide interChange protein H4F89_RS00150 ENOG4105KWW Biogenesis protein H4F89_RS00155 ENOG4105D99 atp gtp-binding protein H4F89_RS00160 ENOG4105R2A (LipO)protein H4F89_RS00170 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) H4F89_RS00185 ENOG4105VG5 Membrane H4F89_RS00190 ENOG4105JP4 Inner membrane protein yidG H4F89_RS00195 ENOG4105J13 transcriptional regulator H4F89_RS00210 ENOG4105W8I Transcriptional regulator H4F89_RS00220 ENOG4105E5M Multidrug resistance protein D H4F89_RS00225 ENOG4105D7V transposase H4F89_RS00250 ENOG4105C7K acetolactate synthase H4F89_RS00255 ENOG4105M71 acetolactate synthase 1 regulatory subunit H4F89_RS00260 ENOG4107FB0 transcriptional regulator DeoR family H4F89_RS00270 ENOG4105EDR glucose galactose transporter H4F89_RS00280 ENOG4108KX4 response regulator H4F89_RS00285 ENOG4105BZU Histidine kinase H4F89_RS00290 ENOG4105CXY transporter H4F89_RS00295 ENOG4105CXY transporter H4F89_RS00300 ENOG4108SAJ Protein of unknown function (DUF1198) H4F89_RS00310 ENOG4105CS2 ec 3.2.1.21 H4F89_RS00335 ENOG4105DNE Transposase H4F89_RS00340 ENOG4108UZ3 Transporter H4F89_RS00345 ENOG4105KT7 mgtC SapB transporter H4F89_RS00350 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic H4F89_RS00365 ENOG4105CHJ isochorismatase hydrolase H4F89_RS00375 ENOG4108TC1 Transcriptional regulator H4F89_RS00380 ENOG4105FV3 H4F89_RS00390 ENOG4105ISV protein with bipartite regulator domain H4F89_RS00405 ENOG4105CT4 transporter H4F89_RS00410 ENOG4105CJQ hydrolase, family 31 H4F89_RS00415 ENOG4105JV1 AsmA family H4F89_RS00420 ENOG4105C2W permease H4F89_RS00425 ENOG4105D6U Sodium Glutamate Symporter H4F89_RS00430 ENOG4105CB5 ATP-dependent DNA helicase recG H4F89_RS00435 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase H4F89_RS00440 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H4F89_RS00460 ENOG4105EN6 Membrane H4F89_RS00475 ENOG4105DSJ YicC domain protein H4F89_RS00480 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) H4F89_RS00490 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) H4F89_RS00500 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H4F89_RS00530 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase H4F89_RS00535 ENOG4105DKP glycosyl transferase, family 9 H4F89_RS00540 ENOG4107RJ7 Glycosyl transferase (Group 1 H4F89_RS00545 ENOG4107543 (lipo)polysaccharide H4F89_RS00555 ENOG4107XU6 Glycosyl transferase (Group 1 H4F89_RS00560 ENOG4106AH0 Glycosyl Transferase H4F89_RS00565 ENOG4105X1N Glycosyl transferase family 8 H4F89_RS00570 ENOG4108PDR lipopolysaccharide core biosynthesis protein H4F89_RS00575 ENOG4108QD8 lipopolysaccharide core biosynthesis protein H4F89_RS00580 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase H4F89_RS00585 ENOG4108FRV O-antigen ligase H4F89_RS00590 ENOG4105D16 lipopolysaccharide heptosyltransferase i H4F89_RS00595 ENOG4105XA0 heptosyltransferase ii H4F89_RS00600 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) H4F89_RS00605 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H4F89_RS00610 ENOG4105CPQ Dehydrogenase H4F89_RS00615 ENOG4105K64 Glycosyl transferase, family 2 H4F89_RS00620 ENOG4105PXI polysaccharide deacetylase H4F89_RS00625 ENOG41063SB peptidase H4F89_RS00635 ENOG4107YZP Rhodanese domain protein H4F89_RS00640 ENOG4105VW4 glutaredoxin 3 H4F89_RS00645 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) H4F89_RS00650 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H4F89_RS00655 ENOG4105D7W serine acetyltransferase H4F89_RS00660 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H4F89_RS00670 ENOG41073TP transcriptional regulator H4F89_RS00675 ENOG4105DAA L-lactate H4F89_RS00680 ENOG4108YYI Protein of unknown function (DUF2810) H4F89_RS00690 ENOG4105E61 Mannitol repressor protein H4F89_RS00700 ENOG4105CTS PTS system mannitol-specific H4F89_RS00705 ENOG4108U78 Glutathione S-transferase H4F89_RS00715 ENOG4105EM7 Selenocysteine-specific translation elongation factor H4F89_RS00720 ENOG4105C0A alcohol dehydrogenase H4F89_RS00725 ENOG41066F8 ROK family H4F89_RS00730 ENOG4105C26 Dehydrogenase H4F89_RS00735 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase H4F89_RS00740 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase H4F89_RS00745 ENOG4105H6Q decarboxylase H4F89_RS00750 ENOG4105CMG Carbohydrate kinase H4F89_RS00755 ENOG4105DJB Major Facilitator Superfamily H4F89_RS00760 ENOG4108M5W H4F89_RS00765 ENOG4108R66 Conserved Protein H4F89_RS00775 ENOG4105J4Q Transcriptional regulator H4F89_RS00780 ENOG4108XIB electron transport protein ysaA H4F89_RS00785 ENOG4105JKW Valine--pyruvate aminotransferase H4F89_RS00790 ENOG4107T9C Alpha amylase catalytic region H4F89_RS00795 ENOG4108UR8 BAX protein H4F89_RS00800 ENOG4105T16 Transcriptional regulator (AraC family) H4F89_RS00810 ENOG4105CMG Carbohydrate kinase H4F89_RS00815 ENOG410688U Inner membrane protein yiaB H4F89_RS00820 ENOG4105MEV Acyl-transferase H4F89_RS00850 ENOG4105MVF Transcriptional regulator H4F89_RS00855 ENOG4106JH6 (LipO)protein H4F89_RS00865 ENOG4108ZG0 Ompa motb domain protein H4F89_RS00870 ENOG4107QY8 reductase H4F89_RS00875 ENOG4105HNP -acetyltransferase H4F89_RS00880 ENOG4108R3E Dna-3-methyladenine glycosylase i H4F89_RS00885 ENOG4105EAX Putative lipase H4F89_RS00890 ENOG4105DIJ Phosphoethanolamine transferase H4F89_RS00905 ENOG4105DEF Extracellular solute-binding protein, family 5 H4F89_RS00910 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H4F89_RS00915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H4F89_RS00920 ENOG4105C3U ABC transporter H4F89_RS00925 ENOG4108JQ7 (ABC) transporter H4F89_RS00930 ENOG4105C44 Serine transporter H4F89_RS00945 ENOG4105D1V cellulose synthase operon protein YhjU H4F89_RS00950 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT H4F89_RS00960 ENOG410661M cytoplasmic protein H4F89_RS00965 ENOG4105UTS cellulose synthase operon protein YhjQ H4F89_RS00970 ENOG4107QZ7 Cellulose synthase catalytic subunit H4F89_RS00975 ENOG4107EEX Cellulose synthase regulator protein H4F89_RS00980 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) H4F89_RS00985 ENOG4105EJG cellulose synthase H4F89_RS00990 ENOG4105BZU Histidine kinase H4F89_RS01000 ENOG4105CS0 peptidase H4F89_RS01005 ENOG4107SS6 2-dehydro-3-deoxygluconokinase H4F89_RS01010 ENOG4105CMB EAL domain-containing protein H4F89_RS01015 ENOG41066T0 asmA family H4F89_RS01020 ENOG4105CSH Transporter H4F89_RS01025 ENOG4107H3J ribonuclease H4F89_RS01030 ENOG4105CBN LysR family transcriptional regulator H4F89_RS01035 ENOG4106S2D Transcriptional regulator H4F89_RS01055 ENOG4105FDP GntR family transcriptional regulator H4F89_RS01075 ENOG4105DC8 reductase H4F89_RS01080 ENOG4105D6S protein involved in catabolism of external DNA H4F89_RS01090 ENOG4105DGW oligopeptidase A H4F89_RS01100 ENOG4105DJV ribulose-phosphate 3-epimerase H4F89_RS01105 ENOG41080HJ 6-phospho 3-hexuloisomerase H4F89_RS01110 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 H4F89_RS01115 ENOG4105DCT glycerol dehydrogenase H4F89_RS01120 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein H4F89_RS01125 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase H4F89_RS01130 ENOG4107EDW L-fucose operon activator H4F89_RS01140 ENOG4105CTS PTS system mannitol-specific H4F89_RS01145 ENOG4105CHR reductase H4F89_RS01155 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H4F89_RS01160 ENOG4105DUX Transporter H4F89_RS01165 ENOG4108M6U Universal stress protein A H4F89_RS01175 ENOG4105CJ3 phosphate transporter H4F89_RS01180 ENOG4105CBX hi0933 family H4F89_RS01185 ENOG4105D0S secretion protein (HlyD H4F89_RS01190 ENOG4105CJ1 ABC, transporter H4F89_RS01195 ENOG4105CMI transporter H4F89_RS01205 ENOG4107YAK holo-(acyl carrier protein) synthase 2 H4F89_RS01210 ENOG4105DSF transport protein H4F89_RS01220 ENOG4108W1V Lipoprotein H4F89_RS01225 ENOG4105EX9 Membrane H4F89_RS01235 ENOG4105C8Q Methyl-accepting chemotaxis H4F89_RS01245 ENOG4107FS9 Membrane H4F89_RS01255 ENOG4105MG3 Membrane H4F89_RS01260 ENOG4106H78 methyltransferase H4F89_RS01265 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H4F89_RS01270 ENOG4105CAK Cell division ATP-binding protein ftsE H4F89_RS01275 ENOG4105CRP Part of the ABC transporter FtsEX involved in H4F89_RS01285 ENOG4105CP9 extracellular ligand-binding receptor H4F89_RS01290 ENOG4105U59 -acetyltransferase H4F89_RS01295 ENOG4105CP9 extracellular ligand-binding receptor H4F89_RS01300 ENOG4105C32 Amino acid ABC transporter (Permease) H4F89_RS01305 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H4F89_RS01310 ENOG4105C0Z ABC transporter H4F89_RS01315 ENOG4108IV0 ABC, transporter H4F89_RS01320 ENOG4105BZ7 extracellular solute-binding protein family 1 H4F89_RS01325 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component H4F89_RS01340 ENOG4107T6V glycerophosphoryl diester phosphodiesterase H4F89_RS01345 ENOG4105WC8 Conserved Protein H4F89_RS01350 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H4F89_RS01355 ENOG41080QX K07048 phosphotriesterase-related protein H4F89_RS01370 ENOG4108RVA ribokinase H4F89_RS01375 ENOG4105WCN acetyltransferase H4F89_RS01380 ENOG4105D9R oxidoreductase H4F89_RS01385 ENOG4105C2I pirin domain protein H4F89_RS01390 ENOG4105DIQ Transcriptional regulator H4F89_RS01395 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H4F89_RS01400 ENOG4105C6Z Gluconate H4F89_RS01405 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H4F89_RS01410 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H4F89_RS01420 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) H4F89_RS01425 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) H4F89_RS01430 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H4F89_RS01435 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H4F89_RS01440 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) H4F89_RS01445 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) H4F89_RS01450 ENOG4105E98 transcriptional regulator DeoR family H4F89_RS01460 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H4F89_RS01465 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) H4F89_RS01470 ENOG4105C6Z Gluconate H4F89_RS01480 ENOG4105MJ2 Competence protein H4F89_RS01505 ENOG4105XFK Ferrous iron transport protein A H4F89_RS01510 ENOG4105BZM domain protein H4F89_RS01515 ENOG4108RRZ Transcription elongation factor GreB H4F89_RS01525 ENOG4105E0F Histidine kinase H4F89_RS01530 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase H4F89_RS01535 ENOG4108MAJ Membrane H4F89_RS01540 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) H4F89_RS01545 ENOG4105VEJ Heat shock protein H4F89_RS01550 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 H4F89_RS01560 ENOG4107RK2 ADP-ribose diphosphatase NudE H4F89_RS01565 ENOG4108JQC penicillin-binding protein 1A H4F89_RS01570 ENOG4108U1Q Pilus assembly protein H4F89_RS01575 ENOG41065NF Fimbrial assembly family protein H4F89_RS01580 ENOG4105XPX DNA utilization protein HofO H4F89_RS01585 ENOG4105ITY Required for the use of extracellular DNA as a nutrient H4F89_RS01590 ENOG4105E4G Type IV pilus H4F89_RS01600 ENOG4105D49 3-dehydroquinate synthase H4F89_RS01605 ENOG4105EGB membrane protein DamX H4F89_RS01610 ENOG4105DFE Dna adenine methylase H4F89_RS01615 ENOG4105DJV ribulose-phosphate 3-epimerase H4F89_RS01625 ENOG4105C31 Tryptophanyl-tRNA synthetase H4F89_RS01630 ENOG4105VYH H4F89_RS01635 ENOG4107EF2 surface-exposed virulence protein H4F89_RS01640 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H4F89_RS01645 ENOG4107V9H nitrite transporter H4F89_RS01650 ENOG4105WZK nitrite reductase NADPH small subunit H4F89_RS01655 ENOG4107QZF nitrite reductase NADPH large subunit H4F89_RS01665 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H4F89_RS01670 ENOG4106195 uncharacterized protein yhfG H4F89_RS01675 ENOG4105MZU cell filamentation protein H4F89_RS01680 ENOG4105DDQ anthranilate synthase H4F89_RS01685 ENOG4105C8Y Acetylornithine aminotransferase H4F89_RS01690 ENOG410613R integral membrane protein, YccS YhfK family H4F89_RS01695 ENOG4107RYR Transcriptional regulator, Crp Fnr family H4F89_RS01700 ENOG4108UKZ OsmC family H4F89_RS01705 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) H4F89_RS01715 ENOG4105DNZ Alpha Beta Hydrolase H4F89_RS01720 ENOG4105N0V mono-oxygenase ydhR H4F89_RS01750 ENOG4107TT2 Auxin Efflux Carrier H4F89_RS01755 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase H4F89_RS01760 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H4F89_RS01765 ENOG4108K70 Transcriptional regulator H4F89_RS01770 ENOG4105C5H ABC transporter H4F89_RS01785 ENOG4105VKU nucleicacid-binding protein H4F89_RS01790 ENOG4108YZY peptidylprolyl cis-trans isomerase H4F89_RS01795 ENOG4105VRX Protein slyX homolog H4F89_RS01800 ENOG4108V1T peptidylprolyl cis-trans isomerase H4F89_RS01805 ENOG4105WWK YheO domain protein H4F89_RS01830 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H4F89_RS01835 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H4F89_RS01840 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H4F89_RS01845 ENOG4105W53 bacterioferritin-associated ferredoxin H4F89_RS01850 ENOG4108UQY Iron-storage protein H4F89_RS01855 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) H4F89_RS01885 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) H4F89_RS01905 ENOG41083MP 50s ribosomal protein l29 H4F89_RS01910 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H4F89_RS01920 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H4F89_RS01945 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) H4F89_RS01955 ENOG4105VPB 50S ribosomal protein L30 H4F89_RS01965 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H4F89_RS01970 ENOG41067V7 50S ribosomal protein L36 H4F89_RS01985 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H4F89_RS01995 ENOG4108ZT0 50S ribosomal protein l17 H4F89_RS02000 ENOG4105VTS DnaJ-like, subfamily C H4F89_RS02005 ENOG4105W1Y Transcriptional regulator H4F89_RS02010 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system H4F89_RS02015 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) H4F89_RS02020 ENOG4105C1A potassium transporter peripheral membrane H4F89_RS02025 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B H4F89_RS02040 ENOG4105C79 DNA protecting protein DprA H4F89_RS02050 ENOG4108WI1 Dna topoisomerase H4F89_RS02055 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H4F89_RS02065 ENOG4105SG3 Protein of unknown function (DUF1488) H4F89_RS02070 ENOG4108Z0R Transferase H4F89_RS02110 ENOG4105XCM membrane LIPOPROTEIN H4F89_RS02115 ENOG4105BZS acriflavin resistance protein H4F89_RS02120 ENOG4105C1P efflux transporter, rnd family, mfp subunit H4F89_RS02125 ENOG4108XG4 DNA-binding transcriptional regulator H4F89_RS02130 ENOG4105BZU Histidine kinase H4F89_RS02135 ENOG41061ME transport protein H4F89_RS02140 ENOG4105CEC DNA methylase N-4 N-6 H4F89_RS02150 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H4F89_RS02155 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) H4F89_RS02160 ENOG4108IA2 Sodium pantothenate symporter H4F89_RS02165 ENOG4105RG0 Membrane H4F89_RS02170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H4F89_RS02175 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H4F89_RS02190 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H4F89_RS02195 ENOG41062P1 Diguanylate cyclase phosphodiesterase H4F89_RS02205 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) H4F89_RS02210 ENOG4105VQ7 Rod shape-determining protein MreD H4F89_RS02215 ENOG4108Z03 MAF-like protein H4F89_RS02220 ENOG4105C03 ribonuclease H4F89_RS02225 ENOG4105QD6 exported protein H4F89_RS02230 ENOG4105D1U peptidase U62 modulator of DNA gyrase H4F89_RS02235 ENOG4105CR8 Transcriptional regulator H4F89_RS02240 ENOG4105ZQC membrane protein AaeX H4F89_RS02245 ENOG4105Y49 secretion protein, HlyD family H4F89_RS02255 ENOG4105UNR (Barnase) inhibitor H4F89_RS02260 ENOG4105RID UPF0379 protein yhcN H4F89_RS02265 ENOG4105RID UPF0379 protein yhcN H4F89_RS02275 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H4F89_RS02285 ENOG4105C0H protease H4F89_RS02290 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III H4F89_RS02295 ENOG4105D6Z AFG1 family ATPase H4F89_RS02310 ENOG4107MKT Stringent starvation protein a H4F89_RS02315 ENOG4105KB2 stringent starvation protein b H4F89_RS02330 ENOG4105JHE Major Facilitator Superfamily H4F89_RS02335 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) H4F89_RS02345 ENOG4108R66 Conserved Protein H4F89_RS02350 ENOG4108FZ9 Chaperone H4F89_RS02355 ENOG4105DZC cytosine deaminase H4F89_RS02360 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin H4F89_RS02370 ENOG4105BZ8 glutamate synthase H4F89_RS02375 ENOG4105CBC glutamate synthase H4F89_RS02380 ENOG4105N5T Radical SAM Protein H4F89_RS02385 ENOG4105BZU Histidine kinase H4F89_RS02390 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain H4F89_RS02400 ENOG4108NIH transferase activity, transferring phosphorus-containing groups H4F89_RS02405 ENOG41080Z8 PHOSPHOCARRIER protein H4F89_RS02410 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) H4F89_RS02415 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN H4F89_RS02420 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA H4F89_RS02425 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H4F89_RS02430 ENOG4108IUZ ABC transporter H4F89_RS02435 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA H4F89_RS02440 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) H4F89_RS02445 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase H4F89_RS02450 ENOG4105C2X Arabinose 5-phosphate isomerase H4F89_RS02455 ENOG4105FEU K -dependent Na -Ca exchanger H4F89_RS02460 ENOG4105DHJ ABC, transporter H4F89_RS02465 ENOG4105CY3 ABC transporter, permease H4F89_RS02470 ENOG4107PE3 Mammalian cell entry related domain protein H4F89_RS02475 ENOG4105E3I toluene tolerance H4F89_RS02480 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane H4F89_RS02485 ENOG4105VFK BolA family H4F89_RS02495 ENOG4105HVQ Regulatory factor of maltose metabolism H4F89_RS02500 ENOG4105EAH synthase H4F89_RS02510 ENOG4105K46 50S ribosomal protein l27 H4F89_RS02515 ENOG4105QYV Membrane H4F89_RS02520 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H4F89_RS02525 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase H4F89_RS02530 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H4F89_RS02535 ENOG4105HBR Rna-binding protein H4F89_RS02545 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H4F89_RS02550 ENOG4105EEI dihydropteroate synthase H4F89_RS02555 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) H4F89_RS02560 ENOG4105NTZ Preprotein translocase subunit SecG H4F89_RS02570 ENOG4105CDH Citrulline--aspartate ligase H4F89_RS02580 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) H4F89_RS02585 ENOG4105CHV Transcription elongation factor NusA H4F89_RS02590 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) H4F89_RS02600 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H4F89_RS02625 ENOG4105C1J atp-dependent rna helicase H4F89_RS02630 ENOG4105CIC tryptophan-specific transport protein H4F89_RS02635 ENOG4105DEN Luciferase family H4F89_RS02655 ENOG4108YYD acetyltransferase H4F89_RS02670 ENOG4107R7Y intracellular protease Pfpi family H4F89_RS02675 ENOG4105K4T epimerase H4F89_RS02680 ENOG4105W4M Transport-associated protein H4F89_RS02685 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H4F89_RS02700 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H4F89_RS02705 ENOG4105D2N Aldolase H4F89_RS02710 ENOG4105E70 isomerase H4F89_RS02715 ENOG4105CE4 GlcNAc 6-P deacetylase H4F89_RS02720 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of H4F89_RS02725 ENOG4105E98 transcriptional regulator DeoR family H4F89_RS02730 ENOG4105CTX dehydratase H4F89_RS02735 ENOG4105CNV Aldolase H4F89_RS02740 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H4F89_RS02755 ENOG4108TC1 Transcriptional regulator H4F89_RS02760 ENOG4105FV3 H4F89_RS02775 ENOG4108VEV chaperone H4F89_RS02790 ENOG410811B TRANSCRIPTIONal H4F89_RS02795 ENOG4105C7B Threonine dehydratase H4F89_RS02800 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) H4F89_RS02810 ENOG4105C6N Formate acetyltransferase H4F89_RS02815 ENOG4105EJQ L-serine dehydratase H4F89_RS02820 ENOG4105C44 Serine transporter H4F89_RS02830 ENOG4106D80 Uncharacterized protein YhaL H4F89_RS02835 ENOG4108CNN domain protein H4F89_RS02840 ENOG4105CWB LysR family transcriptional Regulator H4F89_RS02845 ENOG4105KAF membrAne H4F89_RS02850 ENOG4105CHF Glutathione S-transferase H4F89_RS02855 ENOG4108VBZ doxx family H4F89_RS02860 ENOG4105YJD H4F89_RS02865 ENOG41090KG Inner membrane protein YqjE H4F89_RS02870 ENOG4105NE1 Conserved Protein H4F89_RS02875 ENOG4105WAY exported protein H4F89_RS02885 ENOG4106W5V Membrane H4F89_RS02890 ENOG4107YCY Transcriptional regulator H4F89_RS02895 ENOG4105DPW Major facilitator superfamily MFS_1 H4F89_RS02905 ENOG4105CTX dehydratase H4F89_RS02910 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) H4F89_RS02915 ENOG4105DU1 integral membrane protein, terc H4F89_RS02920 ENOG4105EE0 oxidoreductase H4F89_RS02925 ENOG4108VKG metal-dependent hydrolase H4F89_RS02935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F89_RS02945 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor H4F89_RS02950 ENOG4105C8Q Methyl-accepting chemotaxis H4F89_RS02955 ENOG4105NTW Transcriptional regulator H4F89_RS02960 ENOG4105Q26 Siderophore-interacting protein H4F89_RS02970 ENOG4108VCA G U mismatch-specific DNA glycosylase H4F89_RS02985 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H4F89_RS02990 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H4F89_RS03005 ENOG4107QPK )-transporter H4F89_RS03010 ENOG4107GFK fumarate H4F89_RS03015 ENOG4106DSS Tartrate dehydratase subunit alpha H4F89_RS03020 ENOG4105EJC lysr family transcriptional regulator H4F89_RS03030 ENOG4107ZVW dihydroneopterin aldolase H4F89_RS03045 ENOG4106MWK domain protein H4F89_RS03050 ENOG4105I7R Adenylate cyclase H4F89_RS03070 ENOG4105W0Z cytoplasmic protein H4F89_RS03075 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H4F89_RS03090 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H4F89_RS03095 ENOG4106032 Glutathionylspermidine synthase H4F89_RS03100 ENOG4105F1G UPF0441 protein H4F89_RS03110 ENOG41087AY ADP-Ribose pyrophosphatase H4F89_RS03115 ENOG4108SX3 cytoplasmic protein H4F89_RS03120 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H4F89_RS03125 ENOG4105IPS esterase H4F89_RS03130 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H4F89_RS03135 ENOG4105VRH Antibiotic biosynthesis monooxygenase H4F89_RS03140 ENOG4105NF4 modulator of drug activity H4F89_RS03145 ENOG4105DHQ Histidine kinase H4F89_RS03150 ENOG4105XJC Two component transcriptional regulator (Winged helix family H4F89_RS03155 ENOG4105H4F exported protein H4F89_RS03160 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H4F89_RS03165 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase H4F89_RS03170 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) H4F89_RS03175 ENOG4105CCT upf0313 protein H4F89_RS03185 ENOG4107QPK )-transporter H4F89_RS03190 ENOG4105CV8 reductase H4F89_RS03195 ENOG4108I6A alcohol dehydrogenase H4F89_RS03200 ENOG4105CF7 AraC family transcriptional regulator H4F89_RS03205 ENOG4108K81 inner membrane protein YghB H4F89_RS03210 ENOG4105C28 cystathionine H4F89_RS03215 ENOG4105CWK Biopolymer transport protein, ExbB H4F89_RS03220 ENOG4108ZZF transport protein (ExbD) H4F89_RS03225 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H4F89_RS03250 ENOG4105C8Q Methyl-accepting chemotaxis H4F89_RS03255 ENOG410900S Protein of unknown function (DUF2623) H4F89_RS03260 ENOG4105E3S small subunit H4F89_RS03265 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H4F89_RS03270 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit H4F89_RS03275 ENOG4105DPX Hydrogenase, large subunit H4F89_RS03280 ENOG4108USZ hydrogenase H4F89_RS03285 ENOG4108WGS hydrogenase 2-specific chaperone H4F89_RS03290 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) H4F89_RS03295 ENOG41082MF Hydrogenase assembly chaperone hypC hupF H4F89_RS03300 ENOG4105S10 periplasmic binding protein H4F89_RS03305 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein H4F89_RS03310 ENOG4105CYM Glutathione S-transferase H4F89_RS03315 ENOG4106032 Glutathionylspermidine synthase H4F89_RS03330 ENOG4105DEI Mannitol dehydrogenase H4F89_RS03340 ENOG4105DPW Major facilitator superfamily MFS_1 H4F89_RS03345 ENOG4108QNI outer membrane porin protein H4F89_RS03350 ENOG4105CT4 transporter H4F89_RS03355 ENOG4105CNT hydrolase family 2 H4F89_RS03360 ENOG4105XEA Tetr family transcriptional regulator H4F89_RS03385 ENOG4105C26 Dehydrogenase H4F89_RS03390 ENOG4105CJP fad dependent oxidoreductase H4F89_RS03400 ENOG4105CUB amino acid H4F89_RS03410 ENOG4108UAJ Transcriptional regulator H4F89_RS03420 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) H4F89_RS03430 ENOG4105CI0 Citrate lyase H4F89_RS03435 ENOG4105DJG MaoC domain protein dehydratase H4F89_RS03440 ENOG4105CYC Transferase H4F89_RS03445 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase H4F89_RS03470 ENOG4105HVQ Regulatory factor of maltose metabolism H4F89_RS03500 ENOG4108UUM single-stranded DNA-binding protein H4F89_RS03575 ENOG4105KT7 mgtC SapB transporter H4F89_RS03580 ENOG4105CFF transcriptional regulator H4F89_RS03610 ENOG4105HMV Fimbrial protein H4F89_RS03620 ENOG4108TTM chaperone H4F89_RS03685 ENOG4105BZV Phosphoadenosine phosphosulfate reductase H4F89_RS03690 ENOG4105GTN ParB Domain Protein Nuclease H4F89_RS03700 ENOG41090A1 ferritin H4F89_RS03725 ENOG4105DFD Na H antiporter H4F89_RS03735 ENOG4105D5Q Arginine ornithine antiporter H4F89_RS03740 ENOG4106HK8 GPR1 FUN34 yaaH family protein H4F89_RS03820 ENOG4108D1K outer membrane usher protein H4F89_RS03855 ENOG4108ESX Receptor H4F89_RS03860 ENOG4105D05 Receptor H4F89_RS03875 ENOG4105DIK (ABC) transporter H4F89_RS03880 ENOG4105CC5 ABC transporter H4F89_RS03885 ENOG4105DSE periplasmic solute binding protein H4F89_RS03890 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region H4F89_RS03895 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) H4F89_RS03915 ENOG4105Z2P Protein of unknown function (DUF465) H4F89_RS03975 ENOG4108UQV Membrane H4F89_RS03980 ENOG4105CXN decarboxylase H4F89_RS03985 ENOG4105EAA nucleoside H4F89_RS03995 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) H4F89_RS04000 ENOG4105CEN a g-specific adenine glycosylase H4F89_RS04010 ENOG41090ED Protein with unknown function (DUF469) H4F89_RS04015 ENOG4105K33 Periplasmic Protein H4F89_RS04020 ENOG4105HDK L-asparaginase H4F89_RS04025 ENOG4105CSA Coproporphyrinogen iii oxidase H4F89_RS04040 ENOG4108VIA integral membrane protein H4F89_RS04045 ENOG4105DFA alanine racemase domain protein H4F89_RS04050 ENOG4105CZX twitching motility protein H4F89_RS04060 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H4F89_RS04070 ENOG4105D7Z glutathione synthase H4F89_RS04075 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H4F89_RS04080 ENOG4105RWS endonuclease I H4F89_RS04090 ENOG4107QNK )-transporter H4F89_RS04120 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) H4F89_RS04130 ENOG4108K0D peptidase, M48 H4F89_RS04135 ENOG4105CV1 Transketolase (EC 2.2.1.1) H4F89_RS04140 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia H4F89_RS04145 ENOG4105CTS PTS system mannitol-specific H4F89_RS04150 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein H4F89_RS04155 ENOG4108Q8A Fructose-1,6-bisphosphatase H4F89_RS04160 ENOG4108R4K DNA-binding, transcriptional regulator H4F89_RS04165 ENOG4107Z1W Fructose transport system kinase H4F89_RS04170 ENOG4108JJB ABC transporter H4F89_RS04175 ENOG4108JJB ABC transporter H4F89_RS04200 ENOG4105BZA Phosphoglycerate kinase H4F89_RS04205 ENOG4105D2N Aldolase H4F89_RS04210 ENOG4105D64 Mechanosensitive ion channel H4F89_RS04220 ENOG4105MPN Membrane H4F89_RS04225 ENOG4105DEQ transcriptional regulator H4F89_RS04230 ENOG4105CYC Transferase H4F89_RS04235 ENOG4108M7F enoyl-CoA hydratase isomerase H4F89_RS04240 ENOG4105DJT lAO AO transport system ATPase H4F89_RS04245 ENOG4105D5P Methylmalonyl-coA mutase H4F89_RS04255 ENOG4105E66 phosphoriboisomerase A H4F89_RS04260 ENOG4108JQ1 Dehydrogenase H4F89_RS04265 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H4F89_RS04285 ENOG4107RAQ aminopeptidase H4F89_RS04290 ENOG4105D0A hydroxylase H4F89_RS04295 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H4F89_RS04300 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) H4F89_RS04310 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor H4F89_RS04315 ENOG4105CS2 ec 3.2.1.21 H4F89_RS04325 ENOG4108UT2 hemolysin iii H4F89_RS04330 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) H4F89_RS04340 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB H4F89_RS04345 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) H4F89_RS04350 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F89_RS04355 ENOG4105T95 Thiol disulfide interChange protein H4F89_RS04360 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H4F89_RS04380 ENOG4108K5P (LipO)protein H4F89_RS04415 ENOG4108T1M outer membrane protein x H4F89_RS04425 ENOG4105X0I Fimbrial H4F89_RS04435 ENOG4106P2F Pfam:Pili_assembly_C H4F89_RS04460 ENOG4108MGN ATP-binding component of a transport system H4F89_RS04465 ENOG4106PHM regulatory protein H4F89_RS04475 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter H4F89_RS04480 ENOG4108MHD transport protein H4F89_RS04490 ENOG4105C5Q Transcriptional regulator H4F89_RS04495 ENOG4105CHU acetyl-coa acetyltransferase H4F89_RS04505 ENOG4105CHR reductase H4F89_RS04510 ENOG4107QNK )-transporter H4F89_RS04520 ENOG4105RQF LysR family Transcriptional regulator H4F89_RS04530 ENOG4105DDV Transcriptional regulator (LacI family H4F89_RS04545 ENOG4107S74 Lysophospholipid transporter LplT H4F89_RS04550 ENOG4105CPC Aldo Keto reductase H4F89_RS04555 ENOG4105SUV lipoprotein YgdR H4F89_RS04560 ENOG4105EE5 Membrane protein terC H4F89_RS04570 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H4F89_RS04575 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase H4F89_RS04590 ENOG4105IPU prepilin peptidase dependent protein A H4F89_RS04595 ENOG4105JCS prepilin peptidase dependent protein H4F89_RS04600 ENOG4105SEN Protein of unknown function (DUF2509) H4F89_RS04605 ENOG4105RVB Prepilin peptidase dependent protein c H4F89_RS04610 ENOG4105DSY exodeoxyribonuclease V, gamma H4F89_RS04615 ENOG4107QXK peptidase H4F89_RS04620 ENOG4107QKA exodeoxyribonuclease V beta H4F89_RS04625 ENOG4107QYX exodeoxyribonuclease v alpha H4F89_RS04630 ENOG4108EKC n-acetylglutamate synthase H4F89_RS04635 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H4F89_RS04650 ENOG4105CA3 membrane-bound lytic murein transglycosylase H4F89_RS04655 ENOG4105CUZ uba thif-type nad fad binding protein H4F89_RS04660 ENOG4105FR1 rard protein H4F89_RS04665 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) H4F89_RS04670 ENOG4105C9B Cysteine desulfurase H4F89_RS04675 ENOG4105M5B (LipO)protein H4F89_RS04680 ENOG4105ETT transcriptional Regulator, LysR family H4F89_RS04685 ENOG4105M08 Membrane H4F89_RS04695 ENOG4107EDW L-fucose operon activator H4F89_RS04705 ENOG4105CMG Carbohydrate kinase H4F89_RS04715 ENOG4105EDR glucose galactose transporter H4F89_RS04720 ENOG4107W7X Aldolase H4F89_RS04725 ENOG4105C0A alcohol dehydrogenase H4F89_RS04735 ENOG4105EJQ L-serine dehydratase H4F89_RS04740 ENOG4105C44 Serine transporter H4F89_RS04745 ENOG4105EWT decarboxylase family H4F89_RS04760 ENOG4105WP7 tRNA pseudouridine synthase C H4F89_RS04765 ENOG4105DR9 pseudouridine synthase H4F89_RS04770 ENOG4105QDK Flavodoxin H4F89_RS04775 ENOG4105DJB Major Facilitator Superfamily H4F89_RS04780 ENOG4105EQX glucarate dehydratase H4F89_RS04785 ENOG4105BZW Glycerate kinase H4F89_RS04790 ENOG4105BZU Histidine kinase H4F89_RS04800 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H4F89_RS04805 ENOG4105DXN mazG family H4F89_RS04815 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H4F89_RS04820 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H4F89_RS04825 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) H4F89_RS04830 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase H4F89_RS04840 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) H4F89_RS04845 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) H4F89_RS04855 ENOG4105DTT CRISPR-associated helicase, cas3 H4F89_RS04860 ENOG4105CYR Crispr-associated protein, cse1 family H4F89_RS04870 ENOG41060M0 Crispr-associated protein, cse4 family H4F89_RS04875 ENOG4108VWQ crispr-associated protein H4F89_RS04885 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) H4F89_RS04890 ENOG4105PWE CRISPR-associated protein cas2 H4F89_RS04895 ENOG4108MXK alkaline phosphatase isozyme conversion H4F89_RS04915 ENOG4105N0Z inner membrane protein ygbE H4F89_RS04950 ENOG4108K5P (LipO)protein H4F89_RS04960 ENOG4105KZM cytoplasmic protein H4F89_RS04965 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H4F89_RS04970 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H4F89_RS04980 ENOG4105MVE transcriptional regulator H4F89_RS04990 ENOG4105G63 Type III effector Hrp-dependent H4F89_RS05000 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H4F89_RS05005 ENOG4105EXW epimerase dehydratase H4F89_RS05010 ENOG4105C6Z Gluconate H4F89_RS05015 ENOG4105JQN Transcriptional regulator H4F89_RS05020 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F89_RS05040 ENOG41090HZ type iii secretion H4F89_RS05050 ENOG4108N8R Invasion protein H4F89_RS05055 ENOG4108HR8 type iii secretion H4F89_RS05060 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone H4F89_RS05065 ENOG4108JIR Flagellum-specific ATP synthase H4F89_RS05070 ENOG41077MC Secretory protein (Associated with virulence) H4F89_RS05075 ENOG41078G4 surface presentation of H4F89_RS05085 ENOG41075IY surface presentation of antigens protein SpaP H4F89_RS05090 ENOG4105U07 type iii secretion H4F89_RS05095 ENOG4108TN6 type iii secretion H4F89_RS05100 ENOG4108M6W surface presentation of antigens protein SpaS H4F89_RS05110 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE H4F89_RS05120 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC H4F89_RS05130 ENOG41079WB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H4F89_RS05145 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear H4F89_RS05150 ENOG4105FTC Lytic transglycosylase catalytic H4F89_RS05155 ENOG4108YAB Invasion protein H4F89_RS05165 ENOG4108RC9 Type III secretion system protein H4F89_RS05170 ENOG4105Y7Q type iii secretion H4F89_RS05175 ENOG4106BTR H4F89_RS05180 ENOG4108RBT type iii secretion H4F89_RS05215 ENOG4105CC5 ABC transporter H4F89_RS05220 ENOG4105CC5 ABC transporter H4F89_RS05225 ENOG4105DIK (ABC) transporter H4F89_RS05235 ENOG4105VXR cytoplasmic protein H4F89_RS05245 ENOG4105C45 hydrogenase expression formation protein (HypE) H4F89_RS05250 ENOG4105CQS hydrogenase expression formation protein HypD H4F89_RS05255 ENOG41083WG hydrogenase assembly chaperone H4F89_RS05260 ENOG4107RSS Hydrogenase accessory protein HypB H4F89_RS05265 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) H4F89_RS05270 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA H4F89_RS05275 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) H4F89_RS05280 ENOG4107R30 NADH dehydrogenase H4F89_RS05285 ENOG4107TDF Formate hydrogenlyase subunit 4 H4F89_RS05290 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H4F89_RS05295 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit H4F89_RS05300 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit H4F89_RS05305 ENOG4105I6X formate hydrogenlyase maturation H4F89_RS05310 ENOG4108MG9 hydrogenase 3 maturation protease H4F89_RS05315 ENOG4108RC0 Electron transport protein H4F89_RS05320 ENOG4105C8H hydrogenase maturation protein Hypf H4F89_RS05330 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center H4F89_RS05340 ENOG4105C2X Arabinose 5-phosphate isomerase H4F89_RS05345 ENOG410804X Transcriptional regulator H4F89_RS05350 ENOG4105J92 DNA-binding transcriptional activator GutM H4F89_RS05355 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase H4F89_RS05360 ENOG4105VI0 Pts system, glucitol sorbitol-specific H4F89_RS05365 ENOG4105DZY Pts system, glucitol sorbitol-specific H4F89_RS05370 ENOG410787A Pts system, glucitol sorbitol-specific H4F89_RS05375 ENOG4105CVE Lytic murein transglycosylase H4F89_RS05380 ENOG4107TH8 cina domain protein H4F89_RS05395 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H4F89_RS05400 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) H4F89_RS05430 ENOG4107VXZ Hydrolase H4F89_RS05435 ENOG4105W39 Membrane H4F89_RS05440 ENOG4105D9M gamma-glutamylcysteine synthetase H4F89_RS05445 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) H4F89_RS05450 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F89_RS05455 ENOG4105CW7 secretion protein, HlyD family H4F89_RS05460 ENOG4105NTK Transcriptional repressor Mpra H4F89_RS05470 ENOG4105GIJ Glycine betaine H4F89_RS05475 ENOG4108HQS Glycine betaine H4F89_RS05480 ENOG4108IJ7 Glycine betaine H4F89_RS05485 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H4F89_RS05490 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H4F89_RS05500 ENOG4105WAZ (Glutaredoxin-like protein) NrdH H4F89_RS05505 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H4F89_RS05515 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) H4F89_RS05520 ENOG4108WMJ Protein of unknown function (DUF2002) H4F89_RS05525 ENOG4108RNS Exports L-alanine (By similarity) H4F89_RS05530 ENOG4108X73 DNA- binding protein H4F89_RS05540 ENOG4108V62 Rhodanese domain protein H4F89_RS05545 ENOG41080HT Transcriptional regulator, arsr family H4F89_RS05550 ENOG4105VPI YqaE family transport protein H4F89_RS05555 ENOG4109066 lysm domain bon superfamily protein H4F89_RS05560 ENOG4108PVQ transcriptional regulator H4F89_RS05565 ENOG4105C85 amino acid H4F89_RS05570 ENOG4108JPW Aminotransferase H4F89_RS05575 ENOG4105C26 Dehydrogenase H4F89_RS05580 ENOG4105D5U fad dependent oxidoreductase H4F89_RS05610 ENOG4105DHQ Histidine kinase H4F89_RS05625 ENOG4108MJ5 VirK protein H4F89_RS05635 ENOG4107RNH Outer membrane receptor FepA H4F89_RS05640 ENOG4105NIV Esterase H4F89_RS05665 ENOG4108C33 Resolvase H4F89_RS05670 ENOG4105I03 Flagellin H4F89_RS05695 ENOG4105MX3 Fimbrial H4F89_RS05700 ENOG4106PG1 outer membrane usher protein H4F89_RS05705 ENOG4108TTM chaperone H4F89_RS05710 ENOG4108MY7 Fimbrial H4F89_RS05730 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F89_RS05825 ENOG4108Z1B Cyclase dehydrase H4F89_RS05835 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H4F89_RS05840 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H4F89_RS05855 ENOG4108JU6 CBS domain protein H4F89_RS05860 ENOG4106KVJ cytochrome C assembly protein H4F89_RS05865 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY H4F89_RS05885 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H4F89_RS05890 ENOG4108KHX Diguanylate cyclase H4F89_RS05895 ENOG4108WS1 H4F89_RS05900 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H4F89_RS05905 ENOG4105EHE chorismate mutase- prephenate dehydrogenase H4F89_RS05915 ENOG4105CQC Prephenate dehydratase H4F89_RS05925 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA H4F89_RS05930 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H4F89_RS05935 ENOG4105C34 Pseudouridine synthase H4F89_RS05940 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H4F89_RS05945 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H4F89_RS05975 ENOG4105CSH Transporter H4F89_RS05980 ENOG4105T42 (LipO)protein H4F89_RS05985 ENOG4105JIM Phosphatidylserine synthase H4F89_RS05990 ENOG4105CD5 CoA-binding domain protein H4F89_RS05995 ENOG4106IUH DTW domain containing protein H4F89_RS06000 ENOG4105K63 Thioredoxin H4F89_RS06005 ENOG4105EIB trna rrna methyltransferase H4F89_RS06015 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) H4F89_RS06020 ENOG4105C1J atp-dependent rna helicase H4F89_RS06030 ENOG4108IYU L-aspartate oxidase H4F89_RS06055 ENOG4105WMJ Positive regulator of sigma E, RseC MucC H4F89_RS06085 ENOG4105C3F Signal peptidase i H4F89_RS06115 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H4F89_RS06120 ENOG4106G6Q Transcriptional regulator H4F89_RS06135 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB H4F89_RS06140 ENOG4108Z6B deaminase H4F89_RS06145 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) H4F89_RS06155 ENOG4108ETH Formylglycinamide ribotide synthetase H4F89_RS06160 ENOG4107WP9 Histidine kinase H4F89_RS06165 ENOG4108SKK alpha helix protein H4F89_RS06170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H4F89_RS06180 ENOG4105DUX Transporter H4F89_RS06185 ENOG4105CXN decarboxylase H4F89_RS06190 ENOG4105D5Q Arginine ornithine antiporter H4F89_RS06195 ENOG4108M3R transcriptional activator CadC H4F89_RS06200 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H4F89_RS06210 ENOG4105D8G Major Facilitator superfamily H4F89_RS06215 ENOG4108MN2 Stationary phase inducible protein CsiE H4F89_RS06225 ENOG4105D7X high-affinity nickel-transporter H4F89_RS06230 ENOG410810Y Sulfite reductase H4F89_RS06235 ENOG4107SHJ sulfite reductase subunit b H4F89_RS06240 ENOG4105D5B Sulfite reductase, subunit A H4F89_RS06245 ENOG4105ECY inositol monophosphatase H4F89_RS06250 ENOG4105CVS RNA methyltransferase TrmH family, group 1 H4F89_RS06255 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H4F89_RS06260 ENOG4105C3J Cysteine desulfurase H4F89_RS06265 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins H4F89_RS06270 ENOG4108Z4V iron-sulfur cluster assembly H4F89_RS06275 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) H4F89_RS06285 ENOG4108ZIT Ferredoxin, 2FE-2S H4F89_RS06290 ENOG4105WVQ Fe-S assembly protein IscX H4F89_RS06300 ENOG4105YYA enhanced serine sensitivity protein SseB H4F89_RS06305 ENOG4105KHC sulfurtransferase H4F89_RS06310 ENOG4105DN3 alpha-2-macroglobulin domain protein H4F89_RS06315 ENOG4108JQB penicillin-binding protein 1C H4F89_RS06320 ENOG4107QY8 reductase H4F89_RS06325 ENOG4105QAX Iron-sulfur H4F89_RS06340 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H4F89_RS06345 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H4F89_RS06365 ENOG4105N21 Membrane H4F89_RS06370 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H4F89_RS06380 ENOG4105VPD cellular component movement H4F89_RS06390 ENOG4105D4Y metalloprotease H4F89_RS06395 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H4F89_RS06400 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H4F89_RS06455 ENOG41062G3 Protein of unknown function (DUF2633) H4F89_RS06465 ENOG4105BZU Histidine kinase H4F89_RS06470 ENOG4105C9X ppx gppa phosphatase H4F89_RS06475 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) H4F89_RS06480 ENOG4108V3E phosphoribosylglycinamide formyltransferase H4F89_RS06490 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) H4F89_RS06495 ENOG4105C2W permease H4F89_RS06500 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) H4F89_RS06505 ENOG4105K89 arsenate reductase H4F89_RS06510 ENOG4105ERG peptidase m48, ste24p H4F89_RS06515 ENOG4105C02 permease H4F89_RS06520 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR H4F89_RS06525 ENOG4107QQ0 gntp family H4F89_RS06530 ENOG4105BZW Glycerate kinase H4F89_RS06535 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H4F89_RS06540 ENOG4105RH4 Glycine cleavage system transcriptional repressor H4F89_RS06545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H4F89_RS06550 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H4F89_RS06560 ENOG4105CGZ zinc metallopeptidase H4F89_RS06565 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) H4F89_RS06575 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H4F89_RS06580 ENOG4105KUZ arsenate reductase H4F89_RS06590 ENOG4105BZS acriflavin resistance protein H4F89_RS06595 ENOG4105BZU Histidine kinase H4F89_RS06600 ENOG4105BZ8 glutamate synthase H4F89_RS06615 ENOG4107VIJ nudix hydrolase H4F89_RS06620 ENOG4108PVD exported protein H4F89_RS06630 ENOG4105CV1 Transketolase (EC 2.2.1.1) H4F89_RS06640 ENOG4105C6K Malic enzyme H4F89_RS06645 ENOG4105C4X radical SAM domain protein H4F89_RS06650 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place H4F89_RS06655 ENOG4106S4J ethanolamine utilization protein EutP H4F89_RS06660 ENOG4105NDK ethanolamine utilization protein H4F89_RS06665 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase H4F89_RS06670 ENOG4108IJ2 phosphate acetyltransferase H4F89_RS06675 ENOG4105KNY Microcompartments protein H4F89_RS06680 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml H4F89_RS06685 ENOG4108EKI Dehydrogenase H4F89_RS06690 ENOG4107YMV ethanolamine utilization protein H4F89_RS06695 ENOG4105C0A alcohol dehydrogenase H4F89_RS06700 ENOG4105ENY Ethanolamine utilization protein eutH H4F89_RS06705 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase H4F89_RS06710 ENOG4105CPD ethanolamine ammonia-lyase H4F89_RS06720 ENOG4106D67 ethanolamine utilization protein H4F89_RS06725 ENOG4108X49 Ethanolamine utilization protein EutK H4F89_RS06730 ENOG4108K3Z AraC family transcriptional regulator H4F89_RS06740 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase H4F89_RS06745 ENOG4108R6G acetyltransferase H4F89_RS06750 ENOG4105QZU Inner membrane protein YfeZ H4F89_RS06755 ENOG4105E7K (LipO)protein H4F89_RS06760 ENOG4105EZR dyp-type peroxidase family protein H4F89_RS06765 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr H4F89_RS06770 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein H4F89_RS06775 ENOG4108I5D sulfate abc transporter H4F89_RS06780 ENOG4105ECW sulfate abc transporter H4F89_RS06785 ENOG4108IJ6 ABC transporter H4F89_RS06790 ENOG4105C6T cysteine synthase H4F89_RS06795 ENOG41089BK Glutamine amido-transferase H4F89_RS06800 ENOG4105CSW GntR family transcriptional regulator H4F89_RS06805 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) H4F89_RS06815 ENOG4105C5Y PTS System H4F89_RS06820 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H4F89_RS06830 ENOG4105C6T cysteine synthase H4F89_RS06850 ENOG4105VRT cytoplasmic protein H4F89_RS06855 ENOG4105DHU Bile acid H4F89_RS06860 ENOG4108M0I Transcriptional regulator H4F89_RS06895 ENOG4105GXM Putative transcription regulator (DUF1323) H4F89_RS06900 ENOG4105HZG regulatoR H4F89_RS06915 ENOG4108KMM Diguanylate cyclase H4F89_RS06920 ENOG4105D9N nucleoside H4F89_RS06930 ENOG4109076 Conserved Protein H4F89_RS06935 ENOG4105CPC Aldo Keto reductase H4F89_RS06940 ENOG4107RA9 decarboxylase H4F89_RS06955 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) H4F89_RS06960 ENOG410863U PTS System H4F89_RS06965 ENOG4105DC7 peptidase M24 H4F89_RS06970 ENOG4105CN9 Peptidase m42 family protein H4F89_RS06975 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H4F89_RS06980 ENOG4108CIP transcriptional regulator H4F89_RS06985 ENOG4105CHM Aminotransferase H4F89_RS06995 ENOG4105D1S lipid A biosynthesis H4F89_RS07000 ENOG4105W9M Membrane H4F89_RS07005 ENOG4105CXY transporter H4F89_RS07010 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC H4F89_RS07020 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta H4F89_RS07025 ENOG4108NC2 Outer membrane protease H4F89_RS07095 ENOG4105DFP Integrase H4F89_RS07105 ENOG4105S64 Formate nitrite transporter H4F89_RS07110 ENOG410903C (LipO)protein H4F89_RS07115 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation H4F89_RS07120 ENOG4105KZW UPF0381 protein H4F89_RS07135 ENOG4108BY2 phosphohistidine phosphatase H4F89_RS07145 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) H4F89_RS07155 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) H4F89_RS07160 ENOG4105EJ9 Membrane H4F89_RS07165 ENOG4108BPE -transporting atpase H4F89_RS07170 ENOG4105MH2 YfcL protein H4F89_RS07175 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) H4F89_RS07180 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H4F89_RS07195 ENOG4105R8V Transcriptional regulator H4F89_RS07210 ENOG4106WZ1 flagella biosynthesis regulator H4F89_RS07220 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H4F89_RS07230 ENOG4105DQR SNARE associated Golgi H4F89_RS07240 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H4F89_RS07245 ENOG4108S3P Sporulation domain protein H4F89_RS07250 ENOG4105E96 Colicin v production protein H4F89_RS07255 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase H4F89_RS07260 ENOG4108JUB Transcriptional regulator H4F89_RS07270 ENOG4105E5D amino acid H4F89_RS07275 ENOG4106M28 alanine racemase domain protein H4F89_RS07280 ENOG4108IQI permease H4F89_RS07285 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H4F89_RS07290 ENOG4105E89 ABC transporter H4F89_RS07295 ENOG4105E89 ABC transporter H4F89_RS07300 ENOG4105DSP amino acid AbC transporter H4F89_RS07305 ENOG4106YG3 ABC transporter H4F89_RS07310 ENOG4108JEH abc transporter atp-binding protein H4F89_RS07315 ENOG4105ECP epimerase H4F89_RS07320 ENOG4105CYM Glutathione S-transferase H4F89_RS07325 ENOG4108SHQ Glutathione S-transferase H4F89_RS07330 ENOG4108RE9 Phosphodiesterase H4F89_RS07335 ENOG4105PTV Nudix Hydrolase H4F89_RS07340 ENOG4105K2J Transcriptional regulator H4F89_RS07345 ENOG4106ETB IIa component H4F89_RS07355 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC H4F89_RS07360 ENOG4108HHA Transketolase H4F89_RS07365 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H4F89_RS07370 ENOG4105CSX c4-dicarboxylate anaerobic carrier H4F89_RS07375 ENOG4105C6K Malic enzyme H4F89_RS07380 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H4F89_RS07395 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 H4F89_RS07400 ENOG4107QWE )-transporter H4F89_RS07410 ENOG4105CHM Aminotransferase H4F89_RS07415 ENOG4107NQ8 LysR family Transcriptional regulator H4F89_RS07425 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H4F89_RS07430 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H4F89_RS07440 ENOG4105GKE subunit e H4F89_RS07445 ENOG4107QIZ NADH dehydrogenase H4F89_RS07450 ENOG4108IEH NADH dehydrogenase subunit g H4F89_RS07455 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) H4F89_RS07465 ENOG4107UFS subunit j H4F89_RS07475 ENOG4105D65 subunit l H4F89_RS07480 ENOG4105C8S subunit m H4F89_RS07500 ENOG4107YB6 acetyltransferase, (GNAT) family H4F89_RS07505 ENOG4105TNS Conserved Protein H4F89_RS07510 ENOG4105E4F Isochorismate synthase H4F89_RS07525 ENOG4108IPT Naphthoate synthase H4F89_RS07535 ENOG4105CEY Amp-dependent synthetase and ligase H4F89_RS07540 ENOG4106GZG polymyxin resistance protein B H4F89_RS07590 ENOG4108UII YfaZ family H4F89_RS07595 ENOG4108EWA cinA-like protein H4F89_RS07600 ENOG4105DNE Transposase H4F89_RS07605 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H4F89_RS07615 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A H4F89_RS07620 ENOG4105CXY transporter H4F89_RS07625 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase H4F89_RS07630 ENOG4105GZI Transcriptional regulator H4F89_RS07635 ENOG4105CZM Major Facilitator H4F89_RS07640 ENOG4105XPH Ferredoxin H4F89_RS07645 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H4F89_RS07650 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H4F89_RS07655 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H4F89_RS07660 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H4F89_RS07665 ENOG4105BZU Histidine kinase H4F89_RS07670 ENOG41068CG regulatoR H4F89_RS07675 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC H4F89_RS07680 ENOG4105F2I Transposase H4F89_RS07685 ENOG4105FCK Membrane H4F89_RS07690 ENOG4105CJ2 (LipO)protein H4F89_RS07695 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H4F89_RS07700 ENOG4105CF1 Alkylated DNA repair protein H4F89_RS07705 ENOG4105IBP Cyclic peptide transporter H4F89_RS07715 ENOG4108ZNS ferredoxin-type protein NapF H4F89_RS07720 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase H4F89_RS07730 ENOG4108BGM Quinol dehydrogenase periplasmic component H4F89_RS07735 ENOG4105GXZ Ferredoxin-type protein NapH H4F89_RS07740 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) H4F89_RS07745 ENOG4105CUW cytochrome C-TYPE protein H4F89_RS07750 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) H4F89_RS07755 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) H4F89_RS07760 ENOG41060IM Heme exporter protein H4F89_RS07765 ENOG4105X3C heme exporter protein H4F89_RS07775 ENOG4105DA4 cytochrome c-type biogenesis protein H4F89_RS07780 ENOG4107QX9 Thiol disulfide interChange protein H4F89_RS07785 ENOG4105KWW Biogenesis protein H4F89_RS07790 ENOG4105WH1 Two component transcriptional regulator luxr family H4F89_RS07845 ENOG4105W5A BNR Asp-box repeat protein H4F89_RS07850 ENOG4107ENK receptor H4F89_RS07865 ENOG4105E68 Sulfatase H4F89_RS07885 ENOG4105CFI type iii restriction protein res subunit H4F89_RS07890 ENOG4105I08 Pseudouridine synthase H4F89_RS07895 ENOG4105C2C drug resistance transporter, Bcr CflA H4F89_RS07900 ENOG4105HG6 H4F89_RS07905 ENOG4108JQ5 ABC transporter H4F89_RS07910 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component H4F89_RS07915 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component H4F89_RS07920 ENOG4105E43 Extracellular solute-binding protein, family 5 H4F89_RS07925 ENOG4105CXC rtn protein H4F89_RS07930 ENOG4107TT5 NLP P60 protein H4F89_RS07935 ENOG41076MN Phosphoesterase, PA-phosphatase related H4F89_RS07940 ENOG4105CKI cobalamin synthesis protein H4F89_RS07945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H4F89_RS07950 ENOG4105CUW cytochrome C-TYPE protein H4F89_RS07955 ENOG4108EM1 reductase H4F89_RS07960 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) H4F89_RS07965 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H4F89_RS07970 ENOG4105KRS Proteinase inhibitor H4F89_RS07985 ENOG4105S8Q sugar efflux transporter H4F89_RS07990 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein H4F89_RS07995 ENOG4105DE4 1-phosphofructokinase H4F89_RS08000 ENOG4105DM4 PTS System H4F89_RS08010 ENOG4105HMI Membrane H4F89_RS08015 ENOG4105DUM transcriptional regulator, lysR family H4F89_RS08020 ENOG4108IQI permease H4F89_RS08025 ENOG4105D05 Receptor H4F89_RS08030 ENOG4105CXY transporter H4F89_RS08035 ENOG4105EAC phosphoserine phosphatase H4F89_RS08055 ENOG4105EUJ GTP cyclohydrolase i H4F89_RS08060 ENOG4105DHF Membrane H4F89_RS08065 ENOG41060NJ transcriptional regulator H4F89_RS08070 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator H4F89_RS08075 ENOG4105C2J ABC transporter H4F89_RS08080 ENOG4107SDZ Galactoside transport system permease protein mglC H4F89_RS08085 ENOG4107SJI Dehydrogenase H4F89_RS08090 ENOG4105BZ8 glutamate synthase H4F89_RS08095 ENOG4105Y9N Membrane H4F89_RS08100 ENOG4107GZ4 SanA protein H4F89_RS08110 ENOG41067MG lrgb family H4F89_RS08145 ENOG4105MSY salicylate hydroxylase H4F89_RS08150 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) H4F89_RS08160 ENOG4105ETP RND efflux system, outer membrane lipoprotein H4F89_RS08165 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H4F89_RS08170 ENOG4105KHU inner membrane protein YohD H4F89_RS08175 ENOG41069YE inner membrane protein yohC H4F89_RS08180 ENOG41061WM D-Alanyl-D-Alanine H4F89_RS08185 ENOG4105CXG d-lactate dehydrogenase H4F89_RS08190 ENOG4107QK4 glycoside hydrolase, family 3 domain protein H4F89_RS08195 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system H4F89_RS08200 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component H4F89_RS08205 ENOG4108IJ8 ABC transporter H4F89_RS08210 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component H4F89_RS08225 ENOG4108HRK Histidine kinase H4F89_RS08230 ENOG4108NEV two component transcriptional regulator, LytTR family H4F89_RS08235 ENOG4108W15 Protein of unknown function (DUF1456) H4F89_RS08245 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H4F89_RS08250 ENOG4105D1F ATP-binding protein H4F89_RS08265 ENOG4108MQF Chaperone H4F89_RS08270 ENOG4105CW0 outer membrane usher protein H4F89_RS08280 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly H4F89_RS08290 ENOG4105DWF phosphomethylpyrimidine kinase H4F89_RS08295 ENOG4105FDP GntR family transcriptional regulator H4F89_RS08300 ENOG4108TFM Kinase, PfkB family H4F89_RS08305 ENOG4108KD5 ADP-ribosylation crystallin J1 H4F89_RS08310 ENOG4105EAA nucleoside H4F89_RS08315 ENOG4105EIE fructose-bisphosphate aldolase H4F89_RS08330 ENOG41090V3 Tir chaperone protein (CesT) family H4F89_RS08340 ENOG4105CFP Peptidase U32 H4F89_RS08345 ENOG4105E3W Two component transcriptional regulator (Winged helix family H4F89_RS08350 ENOG4105EB3 Histidine kinase H4F89_RS08380 ENOG4105R8A Heat shock protein H4F89_RS08385 ENOG4105D03 DNA-3-methyladenine glycosylase II H4F89_RS08390 ENOG4105BZU Histidine kinase H4F89_RS08400 ENOG4105DHP deoxycytidine triphosphate deaminase H4F89_RS08405 ENOG4108GAE asmA family H4F89_RS08410 ENOG4105EE5 Membrane protein terC H4F89_RS08415 ENOG4105DAY polysaccharide export protein H4F89_RS08420 ENOG4105KJF protein tyrosine phosphatase H4F89_RS08425 ENOG4105D75 Capsular exopolysaccharide family H4F89_RS08430 ENOG41090RK glycosyl transferase H4F89_RS08435 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB H4F89_RS08440 ENOG4107RXY Glycosyl transferase H4F89_RS08445 ENOG4108NYJ Colanic acid H4F89_RS08450 ENOG4105ECJ Glycosyl Transferase H4F89_RS08455 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF H4F89_RS08460 ENOG4105C0K Gdp-mannose 4,6-dehydratase H4F89_RS08465 ENOG4105C30 Nad-dependent epimerase dehydratase H4F89_RS08470 ENOG4105FGF GDP-mannose mannosyl hydrolase H4F89_RS08475 ENOG4106CD9 glycosyl transferase group 1 H4F89_RS08480 ENOG4105CJT Mannose-1-phosphate guanylyltransferase H4F89_RS08485 ENOG4107QKV phosphomannomutase H4F89_RS08490 ENOG4105D3Q Sugar transferase H4F89_RS08495 ENOG4105PSV Polysaccharide Biosynthesis Protein H4F89_RS08500 ENOG4105C74 pyruvyl transferase H4F89_RS08505 ENOG4107T8Q Glycosyl transferase (Group 1 H4F89_RS08510 ENOG4105G1A colanic acid biosynthesis protein H4F89_RS08515 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H4F89_RS08525 ENOG4105C0K Gdp-mannose 4,6-dehydratase H4F89_RS08535 ENOG4105FGF GDP-mannose mannosyl hydrolase H4F89_RS08540 ENOG4105CJT Mannose-1-phosphate guanylyltransferase H4F89_RS08575 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) H4F89_RS08590 ENOG4105C6Y Udp-glucose 6-dehydrogenase H4F89_RS08595 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) H4F89_RS08600 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H4F89_RS08615 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H4F89_RS08620 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H4F89_RS08645 ENOG4107SRH Nad-dependent epimerase dehydratase H4F89_RS08650 ENOG4105EQ1 Transcriptional regulator H4F89_RS08660 ENOG4105CUB amino acid H4F89_RS08665 ENOG4105CJB Exodeoxyribonuclease I H4F89_RS08670 ENOG4108J2R molybdopterin oxidoreductase H4F89_RS08675 ENOG4105QAX Iron-sulfur H4F89_RS08680 ENOG4108NWD Cytochrome H4F89_RS08685 ENOG4105DZ1 carboxypeptidase H4F89_RS08690 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) H4F89_RS08695 ENOG4105DR8 Membrane H4F89_RS08700 ENOG41090HJ UPF0265 protein H4F89_RS08705 ENOG4105JZC GHMP kinase H4F89_RS08715 ENOG4105KTW ethanolamine utilization protein H4F89_RS08720 ENOG4105M3W utilization protein H4F89_RS08725 ENOG4108WT6 Carbon dioxide concentrating mechanism protein H4F89_RS08730 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) H4F89_RS08740 ENOG4108EKI Dehydrogenase H4F89_RS08750 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml H4F89_RS08760 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) H4F89_RS08770 ENOG4105KNY Microcompartments protein H4F89_RS08780 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit H4F89_RS08785 ENOG4108ZFT Dehydratase small subunit H4F89_RS08790 ENOG4105YCI dehydratase medium subunit H4F89_RS08795 ENOG4105DMB glycerol dehydratase H4F89_RS08800 ENOG4105EHR propanediol utilization protein pduB H4F89_RS08805 ENOG4105KNY Microcompartments protein H4F89_RS08815 ENOG4107XVH Transcriptional regulator H4F89_RS08820 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H4F89_RS08825 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) H4F89_RS08830 ENOG41081F0 Precorrin-8x methylmutase H4F89_RS08840 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase H4F89_RS08845 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase H4F89_RS08850 ENOG4105CIA precorrin-4 C(11)-methyltransferase H4F89_RS08855 ENOG4108P62 biosynthesis protein (CbiG) H4F89_RS08860 ENOG4105E4R Precorrin-3B C17-methyltransferase H4F89_RS08865 ENOG4105QUC reductase H4F89_RS08870 ENOG4107PPM cobalt chelatase H4F89_RS08875 ENOG4105DVK Precorrin-2 c20-methyltransferase H4F89_RS08880 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) H4F89_RS08885 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) H4F89_RS08890 ENOG4108V4M Cobalt abc transporter H4F89_RS08895 ENOG4108JJB ABC transporter H4F89_RS08900 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H4F89_RS08905 ENOG4108YZT Adenosylcobinamide kinase H4F89_RS08920 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H4F89_RS08945 ENOG4105F2I Transposase H4F89_RS09025 ENOG4105CZQ inner membrane transport protein YdhC H4F89_RS09040 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H4F89_RS09045 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H4F89_RS09055 ENOG4105HEI LysR family (Transcriptional regulator H4F89_RS09070 ENOG4105UQX Mate efflux family protein H4F89_RS09085 ENOG4105FYV Amp nucleosidase H4F89_RS09150 ENOG4105Y0K Inner membrane protein YedR H4F89_RS09155 ENOG4105EST Metal Dependent Phosphohydrolase H4F89_RS09160 ENOG4105DVF Cytosine-specific methyltransferase H4F89_RS09165 ENOG41090BB DNA mismatch endonuclease (vsr) H4F89_RS09170 ENOG4105FDR Membrane H4F89_RS09175 ENOG4105CKW Inner membrane protein yedI H4F89_RS09180 ENOG4105VNZ cytoplasmic protein H4F89_RS09190 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase H4F89_RS09195 ENOG4105YX3 cellular response to acidity H4F89_RS09205 ENOG4107TKS colanic acid capsular biosynthesis activation protein A H4F89_RS09210 ENOG4105D19 Role in flagellar biosynthesis (By similarity) H4F89_RS09215 ENOG4105VS8 Flagellar biosynthetic protein fliq H4F89_RS09220 ENOG4105CN7 Flagellar biosynthetic protein FliP H4F89_RS09225 ENOG4105K0P flagellar biosynthesis protein H4F89_RS09230 ENOG4105DD5 Flagellar motor switch protein H4F89_RS09235 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H4F89_RS09240 ENOG4107ZI8 flagellar basal body-associated protein flil H4F89_RS09245 ENOG4105WF4 Flagellar hook-length control protein H4F89_RS09250 ENOG4105GSA Flagellar export protein flij H4F89_RS09255 ENOG4108JIR Flagellum-specific ATP synthase H4F89_RS09260 ENOG41090PJ Flagellar assembly protein H4F89_RS09265 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H4F89_RS09270 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) H4F89_RS09275 ENOG4105VQ0 flagellar hook-basal body complex protein fliE H4F89_RS09290 ENOG41066VF YeeE YedE family protein H4F89_RS09295 ENOG4105JCU Inherit from NOG: (Lipo)protein H4F89_RS09300 ENOG4105E5K Alpha-amylase H4F89_RS09310 ENOG4105MQ3 flagellar protein FliS H4F89_RS09315 ENOG4105DTS flagellar hook-associated H4F89_RS09320 ENOG4105I03 Flagellin H4F89_RS09325 ENOG4108C80 FliB family H4F89_RS09330 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H4F89_RS09335 ENOG4108M9K flagella biosynthesis protein FliZ H4F89_RS09340 ENOG4105EAB amino acid AbC transporter H4F89_RS09345 ENOG4105K6H D-cysteine desulfhydrase H4F89_RS09350 ENOG4105E5Q amino acid AbC transporter H4F89_RS09355 ENOG4105CDA abc transporter atp-binding protein H4F89_RS09360 ENOG4105VJY transcriptional regulator H4F89_RS09365 ENOG4105XVG cytoplasmic protein H4F89_RS09375 ENOG4105WH1 Two component transcriptional regulator luxr family H4F89_RS09455 ENOG4105ED4 portal protein H4F89_RS09480 ENOG4105VZ1 Replication Protein H4F89_RS09540 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F89_RS09560 ENOG4106RHG Yeca family H4F89_RS09565 ENOG4105E0U tyrosine-specific transport protein H4F89_RS09570 ENOG4105VVZ metal-binding protein H4F89_RS09575 ENOG41090A1 ferritin H4F89_RS09580 ENOG4105P23 (LipO)protein H4F89_RS09590 ENOG4105N4N Protein of unknown function (DUF2766) H4F89_RS09595 ENOG4108UEC Ferritin-like protein H4F89_RS09610 ENOG4108K4C ec 3.1.3.12 H4F89_RS09620 ENOG4108VA4 Universal stress protein H4F89_RS09630 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) H4F89_RS09635 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region H4F89_RS09640 ENOG4107RD7 Flagellar Motor Protein, MotA H4F89_RS09645 ENOG4105ER2 Ompa motb domain protein H4F89_RS09650 ENOG4105CBS Chea signal transduction histidine kinase H4F89_RS09655 ENOG4108V3W Chemotaxis protein, CheW H4F89_RS09660 ENOG4105C8Q Methyl-accepting chemotaxis H4F89_RS09665 ENOG4105BZU Histidine kinase H4F89_RS09675 ENOG4108VYJ response regulator receiver protein H4F89_RS09680 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) H4F89_RS09685 ENOG4105D00 flagellar biosynthetic protein flhB H4F89_RS09690 ENOG4105D7B Flagellar biosynthesis protein flha H4F89_RS09695 ENOG4105IRD Flagellar protein FlhE H4F89_RS09700 ENOG4105F5H Glycosyl Hydrolase Family 88 H4F89_RS09715 ENOG4106ZCM YecM protein H4F89_RS09735 ENOG4105WJG Glutathione H4F89_RS09740 ENOG41081XQ Conserved Protein H4F89_RS09745 ENOG4105D3W isochorismatase H4F89_RS09755 ENOG4108TIT dATP pyrophosphohydrolase H4F89_RS09760 ENOG4105CDY transcriptional regulatory protein H4F89_RS09770 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H4F89_RS09775 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H4F89_RS09780 ENOG4105FAV ABC, transporter H4F89_RS09790 ENOG4105NXV High-affinity zinc uptake system protein H4F89_RS09795 ENOG4105DR5 peptidase H4F89_RS09800 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase H4F89_RS09805 ENOG4105TNG K13735 adhesin invasin H4F89_RS09815 ENOG4105CA9 Pyruvate kinase H4F89_RS09820 ENOG4106KNT transcriptional regulator H4F89_RS09825 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H4F89_RS09830 ENOG4105C01 Dihydroxy-acid dehydratase H4F89_RS09835 ENOG4108UHU Aldolase H4F89_RS09840 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR H4F89_RS09845 ENOG4105X2V dna damage-inducible protein H4F89_RS09855 ENOG4108Q2J Inner membrane protein YebE H4F89_RS09860 ENOG4105CUG Oligopeptidase b H4F89_RS09865 ENOG4105UMD exodeoxyribonuclease X H4F89_RS09870 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase H4F89_RS09875 ENOG4105MPK DNA polymerase III subunit theta H4F89_RS09880 ENOG4105FXM Copper resistance protein H4F89_RS09885 ENOG4108PNC copper resistance H4F89_RS09890 ENOG4105NKT exported protein H4F89_RS09905 ENOG4105F2I Transposase H4F89_RS09950 ENOG4108TMH cytolethal distending toxin H4F89_RS09975 ENOG4108TTM chaperone H4F89_RS10000 ENOG41064WM Uncharacterized protein YcgX H4F89_RS10005 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling H4F89_RS10015 ENOG4108R1E Serine threonine protein phosphatase 1 H4F89_RS10020 ENOG4105UVW uncharacterized protein yebW H4F89_RS10025 ENOG4105WT8 Protein of unknown function (DUF1480) H4F89_RS10035 ENOG4105DY2 Paraquat-inducible protein b H4F89_RS10040 ENOG4105H2K paraquat-inducible protein a H4F89_RS10045 ENOG4108ZGC gaf domain protein H4F89_RS10055 ENOG4105CN1 protease H4F89_RS10060 ENOG4105D0M Protease HtpX homolog H4F89_RS10070 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F89_RS10075 ENOG4105J4Q Transcriptional regulator H4F89_RS10085 ENOG4106CCY Protein MgrB homolog H4F89_RS10090 ENOG4105Q3Y exported protein H4F89_RS10105 ENOG4105CJN penicillin-binding protein H4F89_RS10110 ENOG4105DHI Methyltransferase H4F89_RS10125 ENOG4105F3R pts system mannose fructose sorbose family iid H4F89_RS10130 ENOG4105ETZ PTS System H4F89_RS10135 ENOG4105DAS pts system H4F89_RS10140 ENOG4105EE5 Membrane protein terC H4F89_RS10145 ENOG4107XTP (EAL) domain protein H4F89_RS10150 ENOG4105EJQ L-serine dehydratase H4F89_RS10160 ENOG4105CRQ synthase (Component I) H4F89_RS10165 ENOG4105X5C UPF0181 protein H4F89_RS10170 ENOG4105M4H endoribonuclease L-psp H4F89_RS10175 ENOG4105DVT helicase H4F89_RS10180 ENOG41072GX Peptidase M22 Glycoprotease H4F89_RS10185 ENOG4105Y4Z Outer Membrane Lipoprotein H4F89_RS10190 ENOG4105CEY Amp-dependent synthetase and ligase H4F89_RS10195 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) H4F89_RS10205 ENOG4107QMS site-determining protein H4F89_RS10220 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase H4F89_RS10235 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation H4F89_RS10245 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) H4F89_RS10250 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H4F89_RS10260 ENOG4105ED1 spovr family H4F89_RS10270 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H4F89_RS10280 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H4F89_RS10290 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) H4F89_RS10305 ENOG4105D82 Glutamate dehydrogenase H4F89_RS10315 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H4F89_RS10320 ENOG4105C4M (Ubiquinol oxidase) subunit I H4F89_RS10325 ENOG4105MVP hydrogenase-1 operon protein HyaF H4F89_RS10330 ENOG4108VXY Hydrogenase-1 operon protein HyaE H4F89_RS10335 ENOG4108USZ hydrogenase H4F89_RS10340 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit H4F89_RS10360 ENOG4108QGT oligogalacturonate-specific porin H4F89_RS10365 ENOG4105CBG Sulfatase H4F89_RS10370 ENOG4105E98 transcriptional regulator DeoR family H4F89_RS10380 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB H4F89_RS10385 ENOG4105ETZ PTS System H4F89_RS10390 ENOG4105F3R pts system mannose fructose sorbose family iid H4F89_RS10395 ENOG4108YTN IIa component H4F89_RS10410 ENOG4105C4X radical SAM domain protein H4F89_RS10415 ENOG4105ENH Sulfatase H4F89_RS10430 ENOG4107ZSV Receptor H4F89_RS10435 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H4F89_RS10455 ENOG4105C0W non-ribosomal peptide synthetase H4F89_RS10470 ENOG4105BZ1 (ABC) transporter H4F89_RS10475 ENOG4105EYM Major Facilitator superfamily H4F89_RS10500 ENOG4105F2I Transposase H4F89_RS10520 ENOG4105DFP Integrase H4F89_RS10525 ENOG4105C3G gtp-binding protein H4F89_RS10535 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria H4F89_RS10540 ENOG4105CHH sulfate transporter H4F89_RS10545 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H4F89_RS10555 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) H4F89_RS10565 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H4F89_RS10575 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H4F89_RS10580 ENOG4108YY7 Invasion gene expression up-regulator SirB H4F89_RS10585 ENOG41063JG Transcriptional regulator H4F89_RS10590 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase H4F89_RS10595 ENOG4105EWV Sodium calcium exchanger membrane region H4F89_RS10600 ENOG4105WS7 Cation transport regulator H4F89_RS10610 ENOG41090EX DsrE family H4F89_RS10615 ENOG4105ID0 Putative invasin H4F89_RS10620 ENOG4105WH1 Two component transcriptional regulator luxr family H4F89_RS10625 ENOG4105BZU Histidine kinase H4F89_RS10630 ENOG4105DQQ Major facilitator superfamily MFS_1 H4F89_RS10635 ENOG4105CRU nitrate reductase, alpha subunit H4F89_RS10640 ENOG4108IUE nitrate reductase beta subunit H4F89_RS10645 ENOG4105R3A Nitrate reductase H4F89_RS10650 ENOG41076YT nitrate reductase, gamma subunit H4F89_RS10675 ENOG4105CIY formyltetrahydrofolate deformylase H4F89_RS10685 ENOG4105D78 K07001 NTE family protein H4F89_RS10690 ENOG4105I93 response regulator H4F89_RS10695 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H4F89_RS10710 ENOG4105C0A alcohol dehydrogenase H4F89_RS10715 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H4F89_RS10720 ENOG4107QSI ABC, transporter H4F89_RS10725 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H4F89_RS10730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H4F89_RS10735 ENOG4105C3U ABC transporter H4F89_RS10740 ENOG4108JQ7 (ABC) transporter H4F89_RS10745 ENOG4105EYW Ion transport protein H4F89_RS10765 ENOG4105K9H YciI-like protein H4F89_RS10770 ENOG410822N TonB family H4F89_RS10775 ENOG4105NAU thioesterase Superfamily protein H4F89_RS10790 ENOG4105PI0 Ferredoxin H4F89_RS10795 ENOG4105EIF outer membrane protein W H4F89_RS10800 ENOG4105WEF catalase H4F89_RS10805 ENOG4108N8X transition metal ion binding H4F89_RS10810 ENOG4108Z9Z response to DNA damage stimulus H4F89_RS10830 ENOG4105DK0 Indole-3-glycerol phosphate synthase H4F89_RS10835 ENOG4108EFP Anthranilate synthase component II H4F89_RS10840 ENOG4105CRQ synthase (Component I) H4F89_RS10850 ENOG4105DB7 PHP domain protein H4F89_RS10855 ENOG4107RTD sua5 ycio yrdc ywlc family protein H4F89_RS10860 ENOG4105FE9 pseudouridine synthase H4F89_RS10865 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase H4F89_RS10870 ENOG4105UBK short-chain dehydrogenase reductase H4F89_RS10875 ENOG4105ERU peptidase H4F89_RS10880 ENOG4105RKX Protein of unknown function (DUF2498) H4F89_RS10885 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H4F89_RS10890 ENOG4107R11 Transcriptional regulator H4F89_RS10905 ENOG4107QM5 aconitate hydratase H4F89_RS10910 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) H4F89_RS10915 ENOG4105EYK Phosphatidylglycerophosphatase B H4F89_RS10920 ENOG4105Q4A inner membrane protein yciS H4F89_RS10925 ENOG4105CFV Tetratricopeptide repeat protein H4F89_RS10935 ENOG4108ZJT translation initiation factor, Sui1 H4F89_RS10940 ENOG41061RM osmotically inducible lipoprotein H4F89_RS10945 ENOG4105N2W Transcriptional regulator H4F89_RS10955 ENOG4105BZU Histidine kinase H4F89_RS10965 ENOG4105Q4T oxidoreductase H4F89_RS10970 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH H4F89_RS10985 ENOG4108JQ2 peptide transport system atp-binding protein H4F89_RS10990 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein H4F89_RS10995 ENOG4108EU3 peptide transport system, permease H4F89_RS11040 ENOG4106EE1 H4F89_RS11050 ENOG4108EKA peptide transport system, permease H4F89_RS11055 ENOG4108J59 Extracellular solute-binding protein, family 5 H4F89_RS11060 ENOG4105E51 psp operon transcriptional activator H4F89_RS11065 ENOG41087YS Phage shock protein A H4F89_RS11070 ENOG4105YYT phage shock protein B H4F89_RS11075 ENOG4105FM1 phage shock protein C H4F89_RS11080 ENOG4105NNG Peripheral inner membrane phage-shock protein H4F89_RS11085 ENOG4107QW3 Sucrose phosphorylase H4F89_RS11090 ENOG4105WEM extracellular solute-binding protein H4F89_RS11095 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component H4F89_RS11100 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component H4F89_RS11105 ENOG4107RRD Dehydrogenase H4F89_RS11110 ENOG4107TYA transient receptor potential locus H4F89_RS11115 ENOG4105CK5 oxidoreductase H4F89_RS11120 ENOG4105C71 hydrolase family 65, central catalytic H4F89_RS11125 ENOG4107URF beta-phospho-glucomutase H4F89_RS11130 ENOG4108IJ9 (ABC) transporter H4F89_RS11135 ENOG4107EFV Outer membrane protein G H4F89_RS11140 ENOG4105FKQ transcriptional regulator H4F89_RS11145 ENOG4105CM6 amino acid regulated cytosolic protein H4F89_RS11155 ENOG4108JU8 Transcriptional regulator H4F89_RS11160 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H4F89_RS11165 ENOG4107S8C mandelate racemase muconate lactonizing H4F89_RS11170 ENOG4105KXI murein peptide amidase A H4F89_RS11190 ENOG4107QSI ABC, transporter H4F89_RS11195 ENOG4105CV8 reductase H4F89_RS11215 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H4F89_RS11235 ENOG4105D64 Mechanosensitive ion channel H4F89_RS11240 ENOG4105S5I Membrane H4F89_RS11245 ENOG4105Q9Y Universal stress protein H4F89_RS11250 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H4F89_RS11255 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H4F89_RS11260 ENOG4108DG9 Smr protein MutS2 H4F89_RS11265 ENOG4105C8Q Methyl-accepting chemotaxis H4F89_RS11275 ENOG4105C1J atp-dependent rna helicase H4F89_RS11280 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) H4F89_RS11300 ENOG410814C multidrug resistance protein H4F89_RS11305 ENOG4108RW8 Universal stress protein F H4F89_RS11310 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) H4F89_RS11320 ENOG4105IKK cytoplasmic protein H4F89_RS11325 ENOG41090X5 Heat shock protein hslJ H4F89_RS11330 ENOG4105C5I Dehydrogenase H4F89_RS11335 ENOG4107H52 Dicarboxylate transport H4F89_RS11340 ENOG410689M (LipO)protein H4F89_RS11345 ENOG4105WXT Conserved Protein H4F89_RS11355 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H4F89_RS11360 ENOG4105CQ7 ATP-dependent helicase H4F89_RS11365 ENOG4107DB1 DUF218 domain H4F89_RS11370 ENOG4105CPW cytochrome b561 H4F89_RS11375 ENOG4108WF3 methyltransferase H4F89_RS11385 ENOG4105E5Q amino acid AbC transporter H4F89_RS11390 ENOG4105CDA abc transporter atp-binding protein H4F89_RS11395 ENOG4105E5Q amino acid AbC transporter H4F89_RS11400 ENOG4107R0W ABC transporter H4F89_RS11410 ENOG4107ZUJ lipid metabolic process H4F89_RS11430 ENOG4105C8Q Methyl-accepting chemotaxis H4F89_RS11435 ENOG4105DDW LysR family Transcriptional regulator H4F89_RS11440 ENOG4105E32 cytoplasmic protein H4F89_RS11445 ENOG4105EBR Carboxylesterase H4F89_RS11455 ENOG4108YYC ycei family H4F89_RS11470 ENOG4108PQ7 sgc region transcriptional regulator H4F89_RS11475 ENOG4108RK0 3-epimerase H4F89_RS11480 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) H4F89_RS11485 ENOG4106P19 photosystem i assembly btpa H4F89_RS11490 ENOG4105DT3 PTS system, galactitol-specific IIc component H4F89_RS11495 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) H4F89_RS11500 ENOG4105CN9 Peptidase m42 family protein H4F89_RS11505 ENOG4108Z9I -acetyltransferase H4F89_RS11510 ENOG4107WE3 acetyltransferase YdcK H4F89_RS11515 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein H4F89_RS11520 ENOG41088CC tellurite resistance protein tehB H4F89_RS11525 ENOG4108KKZ (LipO)protein H4F89_RS11530 ENOG4105DKK Benzoate H4F89_RS11535 ENOG4108JCI Transcriptional regulator H4F89_RS11540 ENOG4105CFP Peptidase U32 H4F89_RS11545 ENOG4105RR0 Protein of unknown function (DUF2554) H4F89_RS11555 ENOG41084BJ Pentapeptide repeat protein H4F89_RS11565 ENOG4105SBG acid phosphatase H4F89_RS11595 ENOG4108UQS dipeptidase H4F89_RS11600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H4F89_RS11615 ENOG410654E Membrane H4F89_RS11635 ENOG4105R71 cytoplasmic protein H4F89_RS11640 ENOG4108T9Y Inner membrane protein ydcZ H4F89_RS11645 ENOG4108Z7F N-acetyltransferase H4F89_RS11650 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H4F89_RS11655 ENOG4108WYP Transcriptional regulator H4F89_RS11660 ENOG4105CHB tonB-dependent Receptor H4F89_RS11665 ENOG4108NS2 receptor H4F89_RS11670 ENOG4105SUV lipoprotein YgdR H4F89_RS11675 ENOG4105C85 amino acid H4F89_RS11690 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase H4F89_RS11695 ENOG4105JAB phenazine biosynthesis protein, phzf family H4F89_RS11745 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H4F89_RS11750 ENOG4108MG3 formate dehydrogenase H4F89_RS11755 ENOG4105DQ4 alcohol dehydrogenase H4F89_RS11760 ENOG4107R1I NAD-dependent malic enzyme H4F89_RS11770 ENOG4105TPS biofilm-dependent modulation protein H4F89_RS11775 ENOG4108Z9K Osmotically inducible protein H4F89_RS11780 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells H4F89_RS11795 ENOG4105XXV Acid-resistance protein H4F89_RS11805 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H4F89_RS11820 ENOG4105C87 Aminotransferase class I and II H4F89_RS11825 ENOG4105DFD Na H antiporter H4F89_RS11830 ENOG41060NJ transcriptional regulator H4F89_RS11855 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) H4F89_RS11880 ENOG4108I5G Major Facilitator superfamily H4F89_RS11885 ENOG4105CPQ Dehydrogenase H4F89_RS11890 ENOG4105C6F GntR Family Transcriptional Regulator H4F89_RS11905 ENOG4105DPX Hydrogenase, large subunit H4F89_RS11910 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit H4F89_RS11930 ENOG4105MVP hydrogenase-1 operon protein HyaF H4F89_RS11965 ENOG4105FFC UPF0187 protein H4F89_RS11975 ENOG4105M0C cytoplasmic protein H4F89_RS11985 ENOG4105C26 Dehydrogenase H4F89_RS11990 ENOG4105EGI Transcriptional regulator H4F89_RS12005 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes H4F89_RS12010 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF H4F89_RS12015 ENOG4106DNR multiple antibiotic resistance protein H4F89_RS12020 ENOG4108ZXC Two component transcriptional regulator, luxr family H4F89_RS12030 ENOG4108594 Permease of the drug metabolite transporter H4F89_RS12035 ENOG4105E5W Transporter H4F89_RS12045 ENOG4108YDI single-species biofilm formation on inanimate substrate H4F89_RS12050 ENOG4108WTK competence damage-inducible protein H4F89_RS12060 ENOG4105DGW oligopeptidase A H4F89_RS12065 ENOG4105EMU Dehydrogenase H4F89_RS12070 ENOG4107XBN GntR Family Transcriptional Regulator H4F89_RS12075 ENOG41061EV selenium-binding protein YdfZ H4F89_RS12080 ENOG4105DEI Mannitol dehydrogenase H4F89_RS12110 ENOG4108MK9 spermidine N(1)-acetyltransferase H4F89_RS12130 ENOG4105KBG Protein of unknown function (DUF1161) H4F89_RS12135 ENOG4107QY8 reductase H4F89_RS12140 ENOG4105C3J Cysteine desulfurase H4F89_RS12145 ENOG4105QAX Iron-sulfur H4F89_RS12150 ENOG4107KGK dmso reductase anchor subunit H4F89_RS12155 ENOG4108NEM leader-binding protein dmsD H4F89_RS12160 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component H4F89_RS12165 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system H4F89_RS12170 ENOG4105E90 ABC transporter H4F89_RS12175 ENOG4108IJ8 ABC transporter H4F89_RS12185 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H4F89_RS12190 ENOG4105DAG ROK family H4F89_RS12195 ENOG4106NZI LysR family Transcriptional regulator H4F89_RS12200 ENOG4105D94 Major Facilitator Superfamily H4F89_RS12210 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap H4F89_RS12225 ENOG4105DSF transport protein H4F89_RS12230 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H4F89_RS12235 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H4F89_RS12240 ENOG4105C5D exported protein H4F89_RS12245 ENOG4105D5Q Arginine ornithine antiporter H4F89_RS12250 ENOG4105RA2 Membrane H4F89_RS12255 ENOG4107EXC regulatoR H4F89_RS12260 ENOG4105FCK Membrane H4F89_RS12270 ENOG4105JJR Histidine kinase H4F89_RS12280 ENOG4105C9Q fumarate hydratase class II H4F89_RS12285 ENOG4107GFK fumarate H4F89_RS12290 ENOG4105EIP mannose-6-phosphate isomerase H4F89_RS12295 ENOG4106J39 exported protein H4F89_RS12300 ENOG4107P2S Transcriptional regulator H4F89_RS12305 ENOG4105CI1 PTS System H4F89_RS12310 ENOG4105C87 Aminotransferase class I and II H4F89_RS12320 ENOG4105D9R oxidoreductase H4F89_RS12325 ENOG4106C6R beta-lactam resistance protein H4F89_RS12335 ENOG4105M9B inner membrane protein ydgK H4F89_RS12360 ENOG4108UQQ Electron transport complex H4F89_RS12370 ENOG4105CSM endonuclease III H4F89_RS12375 ENOG4105DUX Transporter H4F89_RS12380 ENOG4108K3A Glutathione S-transferase H4F89_RS12390 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H4F89_RS12400 ENOG410642K Lysozyme inhibitor H4F89_RS12410 ENOG4108XTF Outer Membrane Lipoprotein H4F89_RS12425 ENOG4105Y49 secretion protein, HlyD family H4F89_RS12430 ENOG4105DSW Fusaric acid resistance protein H4F89_RS12435 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H4F89_RS12440 ENOG4107RGM aldo keto reductase H4F89_RS12445 ENOG4105XZD Fe-S protein H4F89_RS12450 ENOG4108WUH Transcriptional regulator, TetR family H4F89_RS12455 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F89_RS12460 ENOG4108UYE Lactoylglutathione lyase H4F89_RS12465 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) H4F89_RS12470 ENOG4105M2J Glutaredoxin H4F89_RS12475 ENOG4105K4H Nlp p60 protein H4F89_RS12480 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H4F89_RS12495 ENOG4105F52 Transcriptional regulator H4F89_RS12500 ENOG4105CZQ inner membrane transport protein YdhC H4F89_RS12505 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H4F89_RS12510 ENOG4108R6K riboflavin synthase, subunit alpha H4F89_RS12530 ENOG4108IUF type iii secretion H4F89_RS12535 ENOG4108TN6 type iii secretion H4F89_RS12540 ENOG41083GP type iii secretion H4F89_RS12545 ENOG4108HHI Type III secretion system protein H4F89_RS12550 ENOG41063Q7 Type III secretion system protein H4F89_RS12565 ENOG4108JIR Flagellum-specific ATP synthase H4F89_RS12575 ENOG4106H1D secretion system apparatus protein H4F89_RS12580 ENOG4105UQF type iii secretion H4F89_RS12585 ENOG4106563 type III secretion system apparatus protein H4F89_RS12635 ENOG4106FZW pathogenicity island effector protein H4F89_RS12640 ENOG4108SZ7 secretion system effector H4F89_RS12650 ENOG4105ZQI secreted protein H4F89_RS12680 ENOG4105BZU Histidine kinase H4F89_RS12690 ENOG4108XDN Transcriptional regulator H4F89_RS12695 ENOG4107SEY Conserved Protein H4F89_RS12700 ENOG4105RFR Protein of unknown function (DUF2767) H4F89_RS12705 ENOG4108ZXC Two component transcriptional regulator, luxr family H4F89_RS12710 ENOG4106AFQ Histidine kinase H4F89_RS12715 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H4F89_RS12720 ENOG4106WHD Tetrathionate reductase H4F89_RS12725 ENOG4105DB1 molybdopterin oxidoreductase H4F89_RS12730 ENOG4108RVA ribokinase H4F89_RS12745 ENOG4105CUB amino acid H4F89_RS12750 ENOG4105CA9 Pyruvate kinase H4F89_RS12760 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H4F89_RS12775 ENOG4105JRK feS assembly protein SufD H4F89_RS12780 ENOG4105C3K feS assembly ATPase SufC H4F89_RS12785 ENOG4105DIW FeS assembly protein SUFB H4F89_RS12790 ENOG4108Z4V iron-sulfur cluster assembly H4F89_RS12795 ENOG4108ETY sodium dicarboxylate symporter H4F89_RS12800 ENOG410671Z uncharacterized protein ydiH H4F89_RS12805 ENOG4105KA0 thioesterase Superfamily protein H4F89_RS12810 ENOG4105CQB FAD linked oxidase domain protein H4F89_RS12815 ENOG4105IPI Membrane H4F89_RS12830 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) H4F89_RS12840 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H4F89_RS12850 ENOG4105CNG UPF0061 protein H4F89_RS12855 ENOG4108TC0 Diguanylate phosphodiesterase H4F89_RS12860 ENOG4108QBX (LipO)protein H4F89_RS12870 ENOG4108V06 Glutathione peroxidase H4F89_RS12900 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H4F89_RS12905 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H4F89_RS12925 ENOG41082NX 50s ribosomal protein l35 H4F89_RS12930 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H4F89_RS12940 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H4F89_RS12945 ENOG4105KT5 UmuD protein H4F89_RS13080 ENOG4106050 phage regulatory protein, rha family H4F89_RS13085 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 H4F89_RS13110 ENOG4105HGD Antitermination protein H4F89_RS13140 ENOG4105NY2 NinB protein H4F89_RS13145 ENOG4105CDU Replicative dna helicase H4F89_RS13200 ENOG4105VIZ double-strand break repair protein H4F89_RS13220 ENOG41077V0 CPS-53 (KpLE1) prophage H4F89_RS13270 ENOG4108NE3 Salt-induced outer membrane protein H4F89_RS13275 ENOG4105DE4 1-phosphofructokinase H4F89_RS13280 ENOG4105P10 Uncharacterized protein ydiZ H4F89_RS13290 ENOG4107PN8 YfeABCD locus regulator H4F89_RS13295 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 H4F89_RS13300 ENOG4107K5X Membrane-bound metal-dependent hydrolase H4F89_RS13305 ENOG4108ETY sodium dicarboxylate symporter H4F89_RS13310 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) H4F89_RS13315 ENOG4105CH6 catalase H4F89_RS13325 ENOG4105F8D glycoside hydrolase family 4 H4F89_RS13330 ENOG4105EZV Transcriptional regulator H4F89_RS13335 ENOG4105VCP PTS System H4F89_RS13340 ENOG4105CK1 PTS System H4F89_RS13345 ENOG4105VZJ PTS System H4F89_RS13350 ENOG4105KKI DNA-binding transcriptional activator OsmE H4F89_RS13360 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) H4F89_RS13365 ENOG4108SPG Periplasmic Protein H4F89_RS13395 ENOG4105CGK Exodeoxyribonuclease III H4F89_RS13400 ENOG4105M6F mutator MutT protein H4F89_RS13405 ENOG4105MTM Protein of unknown function (DUF1496) H4F89_RS13410 ENOG4105D82 Glutamate dehydrogenase H4F89_RS13415 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H4F89_RS13420 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) H4F89_RS13425 ENOG41069NU Nitroreductase H4F89_RS13430 ENOG4105D07 Signal peptide peptidase, SppA H4F89_RS13435 ENOG4105HDK L-asparaginase H4F89_RS13440 ENOG4108RWI nicotinamidase H4F89_RS13445 ENOG4105VUT cytoplasmic protein H4F89_RS13455 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H4F89_RS13460 ENOG4105DSB aldose 1-epimerase H4F89_RS13465 ENOG4105CV8 reductase H4F89_RS13470 ENOG4105C4X radical SAM domain protein H4F89_RS13475 ENOG4105GNX MltA-interacting MipA family protein H4F89_RS13480 ENOG4105CYN Serine protein kinase H4F89_RS13490 ENOG4108KHP Diguanylate cyclase H4F89_RS13495 ENOG4108KXH Ybak prolyl-tRNA synthetase associated H4F89_RS13510 ENOG4105R1U AraC Family Transcriptional Regulator H4F89_RS13515 ENOG4105DJ2 Major Facilitator Superfamily H4F89_RS13520 ENOG4105K78 MarR family Transcriptional regulator H4F89_RS13530 ENOG4105UCG Domain of unknown function (DUF333) H4F89_RS13535 ENOG4106G4W H4F89_RS13540 ENOG4105Y3U Transglycosylase-associated protein H4F89_RS13550 ENOG4105YP6 Domain of unknown function (DUF1869) H4F89_RS13555 ENOG4108YS1 cytoplasmic protein H4F89_RS13565 ENOG4106PMH Extracellular solute-binding protein family 3 H4F89_RS13570 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) H4F89_RS13580 ENOG4108Z6Z Transcriptional regulator H4F89_RS13595 ENOG4108MEK Metal-binding protein YodA H4F89_RS13610 ENOG4105D64 Mechanosensitive ion channel H4F89_RS13615 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) H4F89_RS13620 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) H4F89_RS13645 ENOG4108VKM cytochrome b561 H4F89_RS13655 ENOG4108ZNX Heat shock protein H4F89_RS13680 ENOG4105H38 Membrane H4F89_RS13690 ENOG41060EU Cold shock-like protein H4F89_RS13695 ENOG4106F2Y RICIN H4F89_RS13700 ENOG4105Y50 Virulence Protein H4F89_RS13715 ENOG4105DTD Dehydrogenase H4F89_RS13720 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium H4F89_RS13725 ENOG4105QYK bacteriophage lambda Bor protein homolog H4F89_RS13735 ENOG4105F2I Transposase H4F89_RS13835 ENOG4108W9T type 1 fimbriae regulatory protein H4F89_RS13840 ENOG4108HMX isocitrate dehydrogenase (NADP) H4F89_RS13845 ENOG4108R99 pseudouridine synthase H4F89_RS13865 ENOG4107QTF adenylosuccinate lyase H4F89_RS13880 ENOG4105EZE Cupin 4 family protein H4F89_RS13885 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) H4F89_RS13900 ENOG4105D38 putrescine abc transporter H4F89_RS13905 ENOG4108HM4 ABC transporter H4F89_RS13910 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H4F89_RS13915 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) H4F89_RS13920 ENOG4105D60 lipoprotein releasing system transmembrane protein H4F89_RS13925 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H4F89_RS13930 ENOG4105D60 lipoprotein releasing system transmembrane protein H4F89_RS13935 ENOG4108JA2 transcriptioN-repair coupling factor H4F89_RS13940 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H4F89_RS13945 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction H4F89_RS13950 ENOG4108IND Tetr family transcriptional regulator H4F89_RS13955 ENOG4107MBR 17 kDa surface antigen H4F89_RS13960 ENOG4105CEP NADH dehydrogenase H4F89_RS13965 ENOG4105D0Y UPF0227 protein H4F89_RS13980 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) H4F89_RS13985 ENOG41090DQ Lipoprotein H4F89_RS13990 ENOG4105K59 histidine triad (HIT) protein H4F89_RS13995 ENOG4105CNM Receptor H4F89_RS14000 ENOG4105CI1 PTS System H4F89_RS14005 ENOG4105F8V Hydrolase, tatD family H4F89_RS14010 ENOG4107QRG dna polymerase iii H4F89_RS14020 ENOG4105HHA aminodeoxychorismate lyase H4F89_RS14025 ENOG4105YAZ 4-amino-4-deoxychorismate lyase H4F89_RS14030 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H4F89_RS14035 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H4F89_RS14040 ENOG4105CHR reductase H4F89_RS14045 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H4F89_RS14065 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein H4F89_RS14075 ENOG4105EI2 Pseudouridine synthase H4F89_RS14080 ENOG4107QQB Ribonuclease E H4F89_RS14085 ENOG4105DTJ flagellar hook-associated protein H4F89_RS14090 ENOG4105E1Q flagellar hook-associated protein H4F89_RS14095 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj H4F89_RS14100 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) H4F89_RS14110 ENOG4105CGA flagellar basal-body rod protein FlgG H4F89_RS14115 ENOG4108KPB Flagellar basal-body rod protein FlgF H4F89_RS14120 ENOG4105BZE flagellar hook protein, FlgE H4F89_RS14125 ENOG4105W00 Flagellar hook capping protein H4F89_RS14130 ENOG4108ZC9 flagellar basal-body rod protein flgc H4F89_RS14135 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) H4F89_RS14140 ENOG4105CKS Flagella basal body P-ring formation protein flgA H4F89_RS14145 ENOG4105M9M anti-sigma28 factor FlgM H4F89_RS14150 ENOG4105QVD Flagella synthesis protein FlgN H4F89_RS14155 ENOG4105CJR Integral membrane protein (MviN H4F89_RS14160 ENOG4105EP9 oxidoreductase H4F89_RS14170 ENOG4105D9U N-acetyltransferase H4F89_RS14180 ENOG4105E9S glutaredoxin 2 H4F89_RS14185 ENOG4105F3T (LipO)protein H4F89_RS14190 ENOG4105EKE dihydroorotase H4F89_RS14195 ENOG4105MEA DNA damage-inducible protein i H4F89_RS14200 ENOG4105PVA Biofilm formation regulatory protein BssS H4F89_RS14210 ENOG4106974 biofilm formation H4F89_RS14215 ENOG4105DS1 cytochrome b561 H4F89_RS14220 ENOG4108YYC ycei family H4F89_RS14230 ENOG4105D1S lipid A biosynthesis H4F89_RS14235 ENOG4105C6X Major Facilitator H4F89_RS14240 ENOG4108W47 Acidic protein msyB H4F89_RS14245 ENOG4105NAC (LipO)protein H4F89_RS14250 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) H4F89_RS14260 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) H4F89_RS14265 ENOG4107RZC phospholipase d H4F89_RS14275 ENOG41068SS H4F89_RS14280 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) H4F89_RS14285 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin H4F89_RS14290 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers H4F89_RS14295 ENOG41086KC Transcriptional regulator H4F89_RS14300 ENOG4108XDW curli assembly protein CsgE H4F89_RS14305 ENOG4108WYR Curli production assembly transport component, CsgF H4F89_RS14310 ENOG4105P8Q Curli production assembly transport component CsgG H4F89_RS14315 ENOG4108UQ5 membrane protein YcdZ H4F89_RS14320 ENOG4107XHZ cytoplasmic chaperone TorD family protein H4F89_RS14390 ENOG4105FA0 parb-like partition protein H4F89_RS14480 ENOG410679B prophage CP4-57 regulatory protein alpA H4F89_RS14525 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H4F89_RS14530 ENOG4105C6T cysteine synthase H4F89_RS14535 ENOG4105D7W serine acetyltransferase H4F89_RS14540 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H4F89_RS14580 ENOG4106NZI LysR family Transcriptional regulator H4F89_RS14590 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H4F89_RS14610 ENOG4106P37 HTH-type transcriptional regulator YjhI H4F89_RS14650 ENOG4108YXQ IS66 Orf2 family protein H4F89_RS14670 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H4F89_RS14680 ENOG4105CDH Citrulline--aspartate ligase H4F89_RS14715 ENOG4107RJ5 oxidoreductase H4F89_RS14720 ENOG4105JHE Major Facilitator Superfamily H4F89_RS14725 ENOG4108QGT oligogalacturonate-specific porin H4F89_RS14735 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) H4F89_RS14740 ENOG4107RJ1 sodium solute H4F89_RS14745 ENOG4105QEK Transcriptional regulator H4F89_RS14750 ENOG4105D5M phosphate starvation-inducible protein H4F89_RS14770 ENOG4105CK7 Sodium proline symporter H4F89_RS14785 ENOG4108R86 Transcriptional regulator H4F89_RS14790 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 H4F89_RS14795 ENOG4105CS1 NAD(P)H quinone oxidoreductase H4F89_RS14800 ENOG4105XH3 H4F89_RS14805 ENOG4105D6F Phosphatase H4F89_RS14810 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H4F89_RS14815 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H4F89_RS14820 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) H4F89_RS14890 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase H4F89_RS14895 ENOG4105C26 Dehydrogenase H4F89_RS14905 ENOG4108V8F Transcriptional regulator, MarR family H4F89_RS14910 ENOG4105EFA 4-hydroxyphenylacetate H4F89_RS14915 ENOG4107UWN reductase H4F89_RS14920 ENOG4105VT2 5-hydroxyisourate hydrolase H4F89_RS14925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H4F89_RS14930 ENOG4107ZY3 Histidine kinase H4F89_RS14945 ENOG4106YSC H4F89_RS14950 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell H4F89_RS14955 ENOG4106HNN Invasion protein H4F89_RS15035 ENOG4105DUU IucA IucC family protein H4F89_RS15040 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) H4F89_RS15065 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H4F89_RS15130 ENOG4105HRS Antitermination protein H4F89_RS15145 ENOG4106050 phage regulatory protein, rha family H4F89_RS15160 ENOG4107PBH Toxic component of a toxin-antitoxin (TA) module. A H4F89_RS15165 ENOG41070YT Rac prophage H4F89_RS15225 ENOG4108MN8 Membrane H4F89_RS15235 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 H4F89_RS15245 ENOG4108V1U phospholipid-binding protein H4F89_RS15260 ENOG4105K4P CoA-binding domain protein H4F89_RS15270 ENOG4108Z5K methylglyoxal synthase H4F89_RS15275 ENOG41088T4 Helicase IV H4F89_RS15280 ENOG410901E Membrane H4F89_RS15285 ENOG4105EM2 membrane H4F89_RS15290 ENOG4108RZ1 DNA transformation protein H4F89_RS15295 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) H4F89_RS15300 ENOG4105UYK outer membrane protein a H4F89_RS15310 ENOG4105DAN ATP-dependent protease H4F89_RS15315 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) H4F89_RS15320 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) H4F89_RS15325 ENOG4108Q2G (LipO)protein H4F89_RS15330 ENOG4105DY2 Paraquat-inducible protein b H4F89_RS15335 ENOG4105F1S paraquat-inducible protein a H4F89_RS15340 ENOG4105C5H ABC transporter H4F89_RS15345 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H4F89_RS15350 ENOG4105QVC MOSC domain-containing protein H4F89_RS15355 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) H4F89_RS15360 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) H4F89_RS15365 ENOG4105CD8 aminopeptidase N H4F89_RS15375 ENOG4105C5S asparaginyl-tRNA synthetase H4F89_RS15380 ENOG4105FCK Membrane H4F89_RS15385 ENOG4105CGF Aromatic amino acid aminotransferase H4F89_RS15390 ENOG4105C5X domain protein H4F89_RS15395 ENOG4105EAQ (twin-arginine translocation) pathway signal H4F89_RS15400 ENOG4105DIT ErfK YbiS YcfS YnhG family protein H4F89_RS15410 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) H4F89_RS15420 ENOG4106371 Methyltransferase H4F89_RS15425 ENOG4107S90 membrAne H4F89_RS15430 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups H4F89_RS15440 ENOG4105W49 UPF0434 protein H4F89_RS15445 ENOG4105T0Z Conserved Protein H4F89_RS15450 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) H4F89_RS15455 ENOG4105BZ1 (ABC) transporter H4F89_RS15465 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H4F89_RS15470 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H4F89_RS15480 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase H4F89_RS15490 ENOG4107VMU Membrane H4F89_RS15495 ENOG4105DDY UPF0142 protein ycaO H4F89_RS15500 ENOG4105TMB Formate nitrite transporter H4F89_RS15505 ENOG4105C6N Formate acetyltransferase H4F89_RS15510 ENOG4105GUS H4F89_RS15515 ENOG4105F1A Pyruvate formate-lyase H4F89_RS15520 ENOG4105E5D amino acid H4F89_RS15530 ENOG4105CHJ isochorismatase hydrolase H4F89_RS15535 ENOG4107KGK dmso reductase anchor subunit H4F89_RS15540 ENOG4105QAX Iron-sulfur H4F89_RS15545 ENOG4107QY8 reductase H4F89_RS15550 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H4F89_RS15555 ENOG4105D1H recombination factor protein RarA H4F89_RS15565 ENOG4105CNU cell division protein FtsK H4F89_RS15570 ENOG4105EW9 transcriptional regulator AsnC family H4F89_RS15575 ENOG4105C3M thioredoxin reductase H4F89_RS15580 ENOG4108JJ9 ABC, transporter H4F89_RS15585 ENOG4108JJ8 (ABC) transporter H4F89_RS15600 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) H4F89_RS15605 ENOG4105HEI LysR family (Transcriptional regulator H4F89_RS15610 ENOG4105EUB pirin domain protein H4F89_RS15615 ENOG4105CHJ isochorismatase hydrolase H4F89_RS15630 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H4F89_RS15650 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) H4F89_RS15660 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H4F89_RS15685 ENOG4105EQR Transposase IS116 IS110 IS902 H4F89_RS15720 ENOG4108XVM Cytochrome b(562) H4F89_RS15735 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria H4F89_RS15765 ENOG4108SQ9 flavin reductase domain protein, FMN-binding H4F89_RS15775 ENOG4105DFP Integrase H4F89_RS15800 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H4F89_RS15810 ENOG4105VEQ Cold shock protein H4F89_RS15815 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H4F89_RS15820 ENOG4105DJY efflux transporter, rnd family, mfp subunit H4F89_RS15825 ENOG4108MJ5 VirK protein H4F89_RS15830 ENOG4105CPB ATP-dependent endonuclease of the OLD family H4F89_RS15835 ENOG4105DWU Membrane H4F89_RS15845 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H4F89_RS15850 ENOG4105C7K acetolactate synthase H4F89_RS15855 ENOG4105C5W Aldolase H4F89_RS15860 ENOG4105CGD Nad-dependent epimerase dehydratase H4F89_RS15865 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase H4F89_RS15870 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H4F89_RS15880 ENOG41064MM (LipO)protein H4F89_RS15885 ENOG4105E5Z arginine transporter ATP-binding subunit H4F89_RS15890 ENOG4106PMH Extracellular solute-binding protein family 3 H4F89_RS15895 ENOG4105GBT ABC transporter H4F89_RS15900 ENOG4105DMR ABC, transporter H4F89_RS15905 ENOG4106TNF Periplasmic binding protein H4F89_RS15930 ENOG4105RBQ inner membrane protein ybjO H4F89_RS15935 ENOG4105D38 putrescine abc transporter H4F89_RS15940 ENOG4105F38 ABC transporter, permease H4F89_RS15945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H4F89_RS15950 ENOG4107RUE extracellular solute-binding protein family 1 H4F89_RS15955 ENOG4108RMJ sensory transduction regulator H4F89_RS15965 ENOG4108DBC nitroreductase H4F89_RS15970 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress H4F89_RS15975 ENOG41090BQ Glutaredoxin H4F89_RS15980 ENOG4105GWF inner membrane protein YbjM H4F89_RS15990 ENOG4108RFG Tetr family transcriptional regulator H4F89_RS15995 ENOG4106UW1 Major Facilitator superfamily H4F89_RS16000 ENOG4108HCJ Hydrolase H4F89_RS16005 ENOG4107QF7 multi-drug H4F89_RS16010 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H4F89_RS16015 ENOG4107FB0 transcriptional regulator DeoR family H4F89_RS16020 ENOG4105DZ1 carboxypeptidase H4F89_RS16025 ENOG4108TGY Glutathione S-transferase H4F89_RS16030 ENOG4105D8V Glucose sorbosone dehydrogenase H4F89_RS16035 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway H4F89_RS16060 ENOG4108JQ6 ABC transporter H4F89_RS16065 ENOG4105CVM Molybdenum cofactor synthesis domain protein H4F89_RS16070 ENOG4105D06 uba thif-type nad fad binding protein H4F89_RS16075 ENOG4105F1A Pyruvate formate-lyase H4F89_RS16085 ENOG4108HCJ Hydrolase H4F89_RS16090 ENOG41072TH Protein of unknown function (DUF1479) H4F89_RS16095 ENOG4105ETE Transcriptional regulator (LacI family H4F89_RS16100 ENOG4105DPW Major facilitator superfamily MFS_1 H4F89_RS16110 ENOG4105C5H ABC transporter H4F89_RS16115 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H4F89_RS16120 ENOG4105F4P )-transporter H4F89_RS16125 ENOG4105KST dependent repressor H4F89_RS16135 ENOG4108I6E Sulfatase H4F89_RS16140 ENOG4108T1M outer membrane protein x H4F89_RS16155 ENOG4107R0W ABC transporter H4F89_RS16160 ENOG4105E5Q amino acid AbC transporter H4F89_RS16165 ENOG4105CDA abc transporter atp-binding protein H4F89_RS16170 ENOG4105D8X mechanosensitive ion channel H4F89_RS16180 ENOG4105KSC Transcriptional regulator, TraR DksA family H4F89_RS16185 ENOG4105VR4 UPF0379 protein ybiJ H4F89_RS16190 ENOG4108MTB glycosyl transferase family H4F89_RS16195 ENOG4105DVT helicase H4F89_RS16200 ENOG4105C1J atp-dependent rna helicase H4F89_RS16205 ENOG4107MVR Transcriptional regulator H4F89_RS16210 ENOG4105D0S secretion protein (HlyD H4F89_RS16215 ENOG4105CJ1 ABC, transporter H4F89_RS16220 ENOG4107QWP ABC-2 type transporter H4F89_RS16225 ENOG4107QWP ABC-2 type transporter H4F89_RS16230 ENOG4105I9U inner membrane protein ybhQ H4F89_RS16235 ENOG4105X23 Endonuclease Exonuclease phosphatase H4F89_RS16240 ENOG4105DZQ phospholipase D Transphosphatidylase H4F89_RS16245 ENOG4107UXM Membrane H4F89_RS16250 ENOG4105HFZ Membrane H4F89_RS16255 ENOG4108ZAF Molybdopterin H4F89_RS16260 ENOG4105M00 molybdopterin converting factor, subunit 1 H4F89_RS16270 ENOG4108RIR Molybdenum cofactor biosynthesis protein H4F89_RS16280 ENOG4105CHW UPF0052 protein H4F89_RS16295 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H4F89_RS16300 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H4F89_RS16315 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H4F89_RS16320 ENOG4108V1U phospholipid-binding protein H4F89_RS16350 ENOG4105NBR Pectinesterase H4F89_RS16365 ENOG4108K4B hydrolase H4F89_RS16375 ENOG4105E0C molybdate abc transporter H4F89_RS16380 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H4F89_RS16390 ENOG4105F4R Transcriptional regulator mode H4F89_RS16395 ENOG4105DKW ABC transporter H4F89_RS16400 ENOG4105CMR udp-glucose 4-epimerase H4F89_RS16405 ENOG4105F0Z galactose-1-phosphate uridylyltransferase H4F89_RS16415 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H4F89_RS16420 ENOG410901P UPF0249 protein H4F89_RS16425 ENOG4105F8D glycoside hydrolase family 4 H4F89_RS16430 ENOG4105EZV Transcriptional regulator H4F89_RS16435 ENOG4105CK1 PTS System H4F89_RS16445 ENOG4105E0A ABC, transporter H4F89_RS16450 ENOG4105EHG Permease protein H4F89_RS16455 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H4F89_RS16460 ENOG4105JND homeobox protein H4F89_RS16465 ENOG4105PGM cation diffusion facilitator family transporter H4F89_RS16470 ENOG4106Z1T Nicotinamide Mononucleotide Transporter H4F89_RS16510 ENOG4105UFD tol-pal system protein YbgF H4F89_RS16515 ENOG4105KCK Peptidoglycan-associated lipoprotein H4F89_RS16525 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA H4F89_RS16535 ENOG4105E02 MotA TolQ exbB proton channel H4F89_RS16540 ENOG4107YD3 Thioesterase H4F89_RS16545 ENOG4105KJB cyd operon protein YbgE H4F89_RS16555 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H4F89_RS16560 ENOG4105C4M (Ubiquinol oxidase) subunit I H4F89_RS16570 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H4F89_RS16575 ENOG4105CMV Succinyl-CoA synthetase subunit beta H4F89_RS16580 ENOG4105C7S Dehydrogenase H4F89_RS16585 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H4F89_RS16590 ENOG4105E33 succinate dehydrogenase H4F89_RS16595 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H4F89_RS16600 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein H4F89_RS16605 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit H4F89_RS16615 ENOG4105BZN citrate synthase H4F89_RS16620 ENOG4108KK1 membrane protein AbrB duplication H4F89_RS16685 ENOG4108W9T type 1 fimbriae regulatory protein H4F89_RS16700 ENOG4107R7A Allophanate hydrolase subunit 2 H4F89_RS16705 ENOG4105P4J Allophanate hydrolase, subunit 1 H4F89_RS16710 ENOG4107QNR UPF0135 protein H4F89_RS16720 ENOG4105CVP deoxyribo-dipyrimidine photolyase H4F89_RS16725 ENOG4105XIQ Protein of unknown function (DUF2517) H4F89_RS16750 ENOG4105C08 Histidine kinase H4F89_RS16755 ENOG4105EEX Two component transcriptional regulator (Winged helix family H4F89_RS16765 ENOG4105CXN decarboxylase H4F89_RS16770 ENOG4105D5Q Arginine ornithine antiporter H4F89_RS16780 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 H4F89_RS16785 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) H4F89_RS16790 ENOG4105EV9 Alpha Beta Hydrolase H4F89_RS16795 ENOG4105NNH LexA regulated protein H4F89_RS16800 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) H4F89_RS16805 ENOG41090R7 Ferric uptake H4F89_RS16810 ENOG4106P55 Transcriptional regulator H4F89_RS16815 ENOG4107EFR Flavocytochrome c H4F89_RS16820 ENOG41079YP Citrate utilization protein b H4F89_RS16825 ENOG4105CSH Transporter H4F89_RS16830 ENOG4105GX6 (LipO)protein H4F89_RS16835 ENOG4105J5J Outer membrane porin H4F89_RS16845 ENOG4105CI1 PTS System H4F89_RS16855 ENOG4105CE4 GlcNAc 6-P deacetylase H4F89_RS16860 ENOG4105E2R ROK family H4F89_RS16865 ENOG4105D4U had-superfamily hydrolase, subfamily iia H4F89_RS16870 ENOG4105CAQ asparagine synthetase H4F89_RS16910 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H4F89_RS16920 ENOG4105C9A Phoh family H4F89_RS16930 ENOG4108JU5 Magnesium and cobalt efflux protein H4F89_RS16935 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) H4F89_RS16940 ENOG4107RP9 extracellular solute-binding protein, family 3 H4F89_RS16945 ENOG4105EAD ABC transporter H4F89_RS16950 ENOG4105DRP amino acid AbC transporter H4F89_RS16955 ENOG4105CDA abc transporter atp-binding protein H4F89_RS16965 ENOG4107PAI alpha helical protein H4F89_RS16975 ENOG4105C8T Leucyl-tRNA synthetase H4F89_RS16985 ENOG4105DJF DNA polymerase III, delta' subunit H4F89_RS16990 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) H4F89_RS16995 ENOG4107QZB decarboxylase H4F89_RS17000 ENOG4108TGR phosphatase H4F89_RS17005 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) H4F89_RS17010 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) H4F89_RS17015 ENOG4105CJN penicillin-binding protein H4F89_RS17020 ENOG4105CNI cell division protein FtsW H4F89_RS17025 ENOG4105K6T rare lipoprotein A H4F89_RS17030 ENOG4105DZ1 carboxypeptidase H4F89_RS17035 ENOG4108Z43 UPF0250 protein H4F89_RS17045 ENOG41064T2 transcriptional regulator, lysR family H4F89_RS17055 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) H4F89_RS17065 ENOG4107Z6W Protein CrcB homolog H4F89_RS17080 ENOG4105CEE C4-dicarboxylate transporter H4F89_RS17085 ENOG4106YYS transcriptional regulatory protein H4F89_RS17090 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H4F89_RS17095 ENOG4105DUA (citrate (pro-3S)-lyase ligase H4F89_RS17100 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) H4F89_RS17105 ENOG4105CI0 Citrate lyase H4F89_RS17110 ENOG4105CHY citrate lyase, alpha H4F89_RS17115 ENOG4105YGP holo-ACP synthase CitX H4F89_RS17125 ENOG4107QPK )-transporter H4F89_RS17130 ENOG4105KTS ribonuclease H4F89_RS17135 ENOG4105NXH GreA GreB family elongation factor H4F89_RS17140 ENOG4105E2A Dehydrogenase H4F89_RS17145 ENOG4108U51 Universal stress protein H4F89_RS17150 ENOG4108JU3 Alkyl hydroperoxide reductase H4F89_RS17155 ENOG4105D3R alkyl hydroperoxide reductase H4F89_RS17160 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase H4F89_RS17165 ENOG4105DQS Transcriptional regulator H4F89_RS17170 ENOG4105BZV Phosphoadenosine phosphosulfate reductase H4F89_RS17175 ENOG4105GTN ParB Domain Protein Nuclease H4F89_RS17180 ENOG4105CHM Aminotransferase H4F89_RS17185 ENOG4107SCQ Iron-containing alcohol dehydrogenase H4F89_RS17190 ENOG4105VCD cytoplasmic protein H4F89_RS17195 ENOG4105D22 carbon starvation protein H4F89_RS17205 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase H4F89_RS17210 ENOG4105WQI isochorismatase H4F89_RS17215 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H4F89_RS17220 ENOG4105E4F Isochorismate synthase H4F89_RS17225 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein H4F89_RS17230 ENOG4105E8G Major facilitator Superfamily H4F89_RS17235 ENOG4105DQ5 transport system permease protein H4F89_RS17240 ENOG4105TVJ transport system, permease H4F89_RS17245 ENOG4105E0A ABC, transporter H4F89_RS17250 ENOG4108QY5 Ferric enterobactin transport protein H4F89_RS17255 ENOG4105C0W non-ribosomal peptide synthetase H4F89_RS17260 ENOG41085A6 mbth domain-containing protein H4F89_RS17265 ENOG4105E93 esterase H4F89_RS17270 ENOG4107RNH Outer membrane receptor FepA H4F89_RS17275 ENOG4108TSE Transferase H4F89_RS17285 ENOG4105WQ6 Membrane H4F89_RS17290 ENOG4105HFT AraC family transcriptional regulator H4F89_RS17295 ENOG41067SE Tetr family transcriptional regulator H4F89_RS17300 ENOG4105MSB protein, conserved in bacteria H4F89_RS17305 ENOG4108RCM Nitroreductase H4F89_RS17310 ENOG4105FDP GntR family transcriptional regulator H4F89_RS17320 ENOG4105CK1 PTS System H4F89_RS17325 ENOG4105VCP PTS System H4F89_RS17335 ENOG4105CS2 ec 3.2.1.21 H4F89_RS17345 ENOG4105CUY Mechanosensitive ion channel H4F89_RS17350 ENOG4105C85 amino acid H4F89_RS17360 ENOG4108KBJ Inner membrane protein YkgB H4F89_RS17365 ENOG41066GK UPF0379 protein ykgI H4F89_RS17370 ENOG4107QN2 dihydrolipoyl dehydrogenase H4F89_RS17375 ENOG4108K01 transcriptional regulator H4F89_RS17405 ENOG4106KCD HTH_LUXR H4F89_RS17415 ENOG4106721 fimbriae Y protein H4F89_RS17420 ENOG4108Q9V regulatoR H4F89_RS17425 ENOG4108ZI2 Fimbrial protein H4F89_RS17430 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) H4F89_RS17435 ENOG4105CW0 outer membrane usher protein H4F89_RS17440 ENOG4108AF8 Chaperone H4F89_RS17450 ENOG4108WDE Fimbrial protein H4F89_RS17460 ENOG4105WQ3 Rna-binding protein H4F89_RS17470 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H4F89_RS17475 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) H4F89_RS17480 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H4F89_RS17485 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H4F89_RS17495 ENOG4108UMI ABC transporter, permease H4F89_RS17505 ENOG4105D01 (LipO)protein H4F89_RS17515 ENOG4105CV6 ABC transporter, permease H4F89_RS17520 ENOG4108I0Y (ABC) transporter H4F89_RS17525 ENOG4108UJV acyl-CoA thioesterase i H4F89_RS17530 ENOG4105E1F short-chain dehydrogenase reductase H4F89_RS17535 ENOG4107QR8 Thioredoxin H4F89_RS17540 ENOG4105C4B ABC transporter, permease H4F89_RS17545 ENOG41083J0 (ABC) transporter H4F89_RS17550 ENOG4107QX8 SPFH domain, Band 7 family protein H4F89_RS17555 ENOG4105G5H Membrane H4F89_RS17560 ENOG4108Z6Z Transcriptional regulator H4F89_RS17565 ENOG4105C59 p-type ATPase H4F89_RS17570 ENOG4105MBR gumn family H4F89_RS17575 ENOG4108Z66 YbaK ebsC protein H4F89_RS17580 ENOG4105CGH 5'-nucleotidase H4F89_RS17585 ENOG4105EU0 Major facilitator Superfamily H4F89_RS17590 ENOG4105CKD glutathione-regulated potassium-efflux system protein H4F89_RS17595 ENOG4107RE1 Inosine-guanosine kinase H4F89_RS17615 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H4F89_RS17630 ENOG4107QMP dna polymerase iii subunits gamma and tau H4F89_RS17640 ENOG4105WD1 Membrane H4F89_RS17645 ENOG4108URS primosomal replication protein n'' H4F89_RS17650 ENOG4106428 Protein of unknown function (DUF2496) H4F89_RS17665 ENOG4105EGS Mechanosensitive ion channel H4F89_RS17670 ENOG4107XI7 Tetr family transcriptional regulator H4F89_RS17675 ENOG4105C1P efflux transporter, rnd family, mfp subunit H4F89_RS17680 ENOG4105BZS acriflavin resistance protein H4F89_RS17685 ENOG4108UKR Biofilm formation regulator YbaJ H4F89_RS17695 ENOG4108UW5 maltose o-acetyltransferase H4F89_RS17700 ENOG4105GSJ Inner membrane protein ylaC H4F89_RS17715 ENOG41066DG (EAL) domain protein H4F89_RS17725 ENOG41080UX Methyltransferase H4F89_RS17730 ENOG4108MNP Glycoprotein polysaccharide metabolism H4F89_RS17735 ENOG4105C29 acyl-CoA thioesterase H4F89_RS17740 ENOG4105BZU Histidine kinase H4F89_RS17745 ENOG4108YZA Nitrogen regulatory protein pii H4F89_RS17750 ENOG4105BZ1 (ABC) transporter H4F89_RS17755 ENOG4105BZ1 (ABC) transporter H4F89_RS17760 ENOG4108XM1 transcriptional regulator AsnC family H4F89_RS17770 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) H4F89_RS17775 ENOG4108NFA extracellular solute-binding protein H4F89_RS17785 ENOG4108TGP Thioesterase superfamily protein H4F89_RS17790 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein H4F89_RS17795 ENOG4105EIN peptidylprolyl cis-trans isomerase H4F89_RS17800 ENOG4105K70 DNA-binding protein H4F89_RS17805 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H4F89_RS17810 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) H4F89_RS17825 ENOG4105M85 Bola protein H4F89_RS17830 ENOG4105IEY (LipO)protein H4F89_RS17835 ENOG4105EYM Major Facilitator superfamily H4F89_RS17840 ENOG4105E2S oxidase) subunit II H4F89_RS17845 ENOG4105BZ9 Cytochrome C oxidase, subunit I H4F89_RS17850 ENOG4105CCU oxidase (Subunit III) H4F89_RS17855 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) H4F89_RS17870 ENOG4107RDB Major Facilitator H4F89_RS17880 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H4F89_RS17885 ENOG4107S0N DJ-1 family H4F89_RS17900 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H4F89_RS17905 ENOG4105CTB Polyprenyl synthetase H4F89_RS17915 ENOG4105CPC Aldo Keto reductase H4F89_RS17920 ENOG4108ZAI phosphatidylglycerophosphatase a H4F89_RS17925 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H4F89_RS17930 ENOG4107YIM Involved in the transcription termination process (By similarity) H4F89_RS17940 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H4F89_RS17950 ENOG4108KIC (LipO)protein H4F89_RS17955 ENOG4105DRB nucleoside-specific channel-forming protein H4F89_RS17960 ENOG4105N1F Hnh endonuclease H4F89_RS17965 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H4F89_RS17975 ENOG4105VIE preprotein translocase, subunit YajC H4F89_RS17995 ENOG4105D3R alkyl hydroperoxide reductase H4F89_RS18000 ENOG4107R28 alpha amylase, catalytic region H4F89_RS18005 ENOG4105C85 amino acid H4F89_RS18010 ENOG4105CWM branched-chain amino acid transport system II carrier protein H4F89_RS18015 ENOG4105BZU Histidine kinase H4F89_RS18020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H4F89_RS18025 ENOG4107RH8 nuclease SbcCD subunit D H4F89_RS18030 ENOG4105EYH Exonuclease H4F89_RS18035 ENOG4105F27 Major Facilitator H4F89_RS18040 ENOG4105DKQ ROK family H4F89_RS18055 ENOG4105HBA AroM protein H4F89_RS18060 ENOG4105SS3 H4F89_RS18075 ENOG4105II7 pyrroline-5-carboxylate reductase H4F89_RS18080 ENOG4105BZU Histidine kinase H4F89_RS18085 ENOG4105VIF phosphate starvation-inducible protein H4F89_RS18090 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) H4F89_RS18105 ENOG4105CPF Cell wall formation (By similarity) H4F89_RS18110 ENOG4105UNH Membrane H4F89_RS18115 ENOG4105FR5 inner membrane protein YaiY H4F89_RS18120 ENOG4107QS8 (LipO)protein H4F89_RS18125 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 H4F89_RS18130 ENOG4107R6D beta-lactam binding protein AmpH H4F89_RS18135 ENOG4108PNB DNA-binding transcriptional regulator H4F89_RS18145 ENOG4105D52 delta-aminolevulinic acid dehydratase H4F89_RS18150 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H4F89_RS18155 ENOG4105DXD 2-methylcitrate dehydratase H4F89_RS18160 ENOG4105BZN citrate synthase H4F89_RS18165 ENOG4105CR4 methylisocitrate lyase H4F89_RS18170 ENOG4108JU7 Transcriptional regulator H4F89_RS18175 ENOG4105TDT uncharacterized protein yahO H4F89_RS18180 ENOG4105E82 cytochrome subunit of dehydrogenase H4F89_RS18200 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H4F89_RS18205 ENOG4105C4M (Ubiquinol oxidase) subunit I H4F89_RS18215 ENOG4105D8D Type III H4F89_RS18220 ENOG4107QMH DNA methylase H4F89_RS18225 ENOG4105JHE Major Facilitator Superfamily H4F89_RS18250 ENOG4108T1M outer membrane protein x H4F89_RS18265 ENOG4105CXC rtn protein H4F89_RS18280 ENOG4105X0I Fimbrial H4F89_RS18285 ENOG4108VEV chaperone H4F89_RS18290 ENOG4105CW0 outer membrane usher protein H4F89_RS18305 ENOG4105DWP Membrane H4F89_RS18340 ENOG4108SEH involved in lipopolysaccharide biosynthesis H4F89_RS18385 ENOG4108KU3 Integrase H4F89_RS18390 ENOG41067CV Integrase H4F89_RS18395 ENOG410792U CP4-6 prophage H4F89_RS18405 ENOG4106GND H4F89_RS18410 ENOG410693A DNA-binding protein H4F89_RS18415 ENOG4105JXR Protein of unknown function (DUF3296) H4F89_RS18430 ENOG4108MXD gtp-binding protein H4F89_RS18435 ENOG4108KZE transcriptional regulator H4F89_RS18470 ENOG4106H6R UPF0380 protein H4F89_RS18485 ENOG4106549 Antirestriction protein H4F89_RS18490 ENOG4108XS9 dna repair protein H4F89_RS18500 ENOG4105ZS6 Protein of unknown function (DUF987) H4F89_RS18510 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles H4F89_RS18545 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) H4F89_RS18555 ENOG4105FCK Membrane H4F89_RS18565 ENOG4105V1F Fermentation respiration switch protein H4F89_RS18570 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) H4F89_RS18575 ENOG4105CIN aminoacyl-histidine dipeptidase H4F89_RS18585 ENOG4105F7V ErfK ybiS ycfS ynhG family protein H4F89_RS18590 ENOG4105E7A Glutamine amidotransferase H4F89_RS18600 ENOG4107QPN acyl-Coa dehydrogenase H4F89_RS18605 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase H4F89_RS18625 ENOG4105T40 surface antigen msp4 family protein H4F89_RS18635 ENOG4107RZZ dna polymerase iii epsilon subunit H4F89_RS18640 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H4F89_RS18645 ENOG4105D1A Methyltransferase H4F89_RS18655 ENOG4105E9H Lytic Murein transglycosylase H4F89_RS18660 ENOG4105F2W methyltransferase H4F89_RS18670 ENOG4105HEI LysR family (Transcriptional regulator H4F89_RS18705 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase H4F89_RS18715 ENOG4108UMI ABC transporter, permease H4F89_RS18720 ENOG4105D01 (LipO)protein H4F89_RS18725 ENOG4108R8X outer membrane lipoprotein H4F89_RS18730 ENOG4108R96 Methyltransferase, YaeB family H4F89_RS18740 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion H4F89_RS18745 ENOG4108YZN class I peptide chain release factor H4F89_RS18750 ENOG4108VWS Yaeq family H4F89_RS18760 ENOG4105M1T rho-binding antiterminator H4F89_RS18770 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase H4F89_RS18775 ENOG4105CXN decarboxylase H4F89_RS18780 ENOG4108M1A Chitin-binding protein H4F89_RS18785 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) H4F89_RS18790 ENOG4105C0B DNA polymerase III (alpha subunit) H4F89_RS18795 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H4F89_RS18805 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H4F89_RS18810 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H4F89_RS18815 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H4F89_RS18820 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) H4F89_RS18825 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H4F89_RS18835 ENOG4105KNE Phosphatidate cytidylyltransferase H4F89_RS18850 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) H4F89_RS18855 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H4F89_RS18865 ENOG4105CE9 30S ribosomal protein S2 H4F89_RS18870 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H4F89_RS18880 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) H4F89_RS18885 ENOG4105CSH Transporter H4F89_RS18895 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR H4F89_RS18900 ENOG4105C0H protease H4F89_RS18915 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) H4F89_RS18920 ENOG4105EN6 Membrane H4F89_RS18925 ENOG4108YX9 iron--sulfur cluster insertion protein erpA H4F89_RS18940 ENOG4105S6R Iron-hydroxamate transporter permease subunit H4F89_RS18945 ENOG4105J76 Periplasmic binding protein H4F89_RS18950 ENOG4105E0A ABC, transporter H4F89_RS18955 ENOG4105E0K tonB-dependent siderophore receptor H4F89_RS18960 ENOG4105BZ4 penicillin-binding protein H4F89_RS18965 ENOG4105CQ7 ATP-dependent helicase H4F89_RS18970 ENOG4107XID 2'-5' rna ligase H4F89_RS18975 ENOG4105PW4 Sugar fermentation stimulation protein homolog H4F89_RS18980 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters H4F89_RS18985 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) H4F89_RS18990 ENOG4105DJ0 Poly(A) Polymerase H4F89_RS18995 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H4F89_RS19000 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) H4F89_RS19005 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) H4F89_RS19010 ENOG4108A32 Transposase H4F89_RS19015 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) H4F89_RS19020 ENOG4107BJW polysaccharide deacetylase H4F89_RS19025 ENOG4108YTN IIa component H4F89_RS19030 ENOG4105E3A (ABC) transporter H4F89_RS19035 ENOG4105DA5 (ABC) transporter H4F89_RS19040 ENOG41077A9 carbonic anhydrase H4F89_RS19045 ENOG4108UGV hypoxanthine phosphoribosyltransferase H4F89_RS19050 ENOG4105DZG Dehydrogenase H4F89_RS19055 ENOG4105E3B Multicopper oxidase H4F89_RS19060 ENOG4108ZRK uncharacterized protein yacC H4F89_RS19070 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) H4F89_RS19075 ENOG4108UW5 maltose o-acetyltransferase H4F89_RS19080 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) H4F89_RS19085 ENOG4105CNT hydrolase family 2 H4F89_RS19090 ENOG4105ETE Transcriptional regulator (LacI family H4F89_RS19095 ENOG4108ZIG UPF0231 protein H4F89_RS19100 ENOG4107QIJ Aconitate hydratase 2 H4F89_RS19105 ENOG4108NST exported protein H4F89_RS19120 ENOG4107QN2 dihydrolipoyl dehydrogenase H4F89_RS19125 ENOG4107QSN dihydrolipoamide acetyltransferase H4F89_RS19130 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H4F89_RS19145 ENOG4105CT4 transporter H4F89_RS19150 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) H4F89_RS19155 ENOG4106A72 regulatory protein AmpE H4F89_RS19165 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H4F89_RS19170 ENOG4108ZUW Major pilin subunit H4F89_RS19175 ENOG4107QHF type ii secretion system protein e H4F89_RS19180 ENOG4105D7Q type ii secretion system H4F89_RS19185 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H4F89_RS19190 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H4F89_RS19195 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) H4F89_RS19205 ENOG4105M6F mutator MutT protein H4F89_RS19230 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H4F89_RS19235 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H4F89_RS19240 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) H4F89_RS19260 ENOG4105CNI cell division protein FtsW H4F89_RS19270 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H4F89_RS19275 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) H4F89_RS19285 ENOG4105CJN penicillin-binding protein H4F89_RS19290 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H4F89_RS19305 ENOG4107B7Y DNA-binding transcriptional regulator FruR H4F89_RS19310 ENOG4108ZP8 Acetolactate synthase small subunit H4F89_RS19315 ENOG4105C7K acetolactate synthase H4F89_RS19320 ENOG41064T2 transcriptional regulator, lysR family H4F89_RS19330 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H4F89_RS19340 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H4F89_RS19345 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H4F89_RS19350 ENOG4105S8Q sugar efflux transporter H4F89_RS19380 ENOG4108KF1 Membrane H4F89_RS19385 ENOG41063TF transcriptional regulator (AraC H4F89_RS19390 ENOG4105EF1 ribulokinase H4F89_RS19400 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase H4F89_RS19410 ENOG4105CQ2 DNA polymerase H4F89_RS19415 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) H4F89_RS19420 ENOG4105D3G Pseudouridine synthase H4F89_RS19430 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) H4F89_RS19440 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) H4F89_RS19450 ENOG4105NWN ApaG protein H4F89_RS19470 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF H4F89_RS19475 ENOG4105M5B (LipO)protein H4F89_RS19480 ENOG4105C54 Major Facilitator superfamily H4F89_RS19485 ENOG4105WQV ferredoxin-like protein H4F89_RS19490 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase H4F89_RS19505 ENOG4105C94 Transporter H4F89_RS19510 ENOG4105C1G acyl-Coa dehydrogenase H4F89_RS19520 ENOG4105J5T Amp-dependent synthetase and ligase H4F89_RS19525 ENOG4105E39 Enoyl-CoA hydratase H4F89_RS19545 ENOG4108XNW Transcriptional activatory protein CaiF H4F89_RS19550 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H4F89_RS19555 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H4F89_RS19570 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H4F89_RS19585 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase H4F89_RS19600 ENOG4105DTN riboflavin biosynthesis protein ribF H4F89_RS19605 ENOG410647N response to DNA damage stimulus H4F89_RS19615 ENOG41063Z6 transcriptional regulator, lysR family H4F89_RS19630 ENOG41061MV Arylsulfatase H4F89_RS19670 ENOG4106PH7 chaperone H4F89_RS19675 ENOG4105MX3 Fimbrial H4F89_RS19685 ENOG4105MHR Fimbrial protein H4F89_RS19690 ENOG4105CW0 outer membrane usher protein H4F89_RS19695 ENOG4108AF8 Chaperone H4F89_RS19755 ENOG4108QUJ UPF0174 protein YaaW H4F89_RS19760 ENOG4106HK8 GPR1 FUN34 yaaH family protein H4F89_RS19765 ENOG4108RIR Molybdenum cofactor biosynthesis protein H4F89_RS19775 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H4F89_RS19780 ENOG4105BZG amino acid carrier protein H4F89_RS19790 ENOG4105D98 threonine synthase H4F89_RS19800 ENOG4105CFH Aspartokinase H4F89_RS19810 ENOG4106FVC RNA methyltransferase H4F89_RS19815 ENOG410759A H4F89_RS19820 ENOG41065U4 response regulator H4F89_RS19840 ENOG4108RH0 Crea protein H4F89_RS19845 ENOG4105UEI Transcriptional Regulator AraC Family H4F89_RS19855 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H4F89_RS19865 ENOG4107SC1 transglycosylase H4F89_RS19870 ENOG4105C5H ABC transporter H4F89_RS19875 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase H4F89_RS19880 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H4F89_RS19885 ENOG4105EAC phosphoserine phosphatase H4F89_RS19890 ENOG41062Z9 Membrane H4F89_RS19920 ENOG4105G0K glycine radical enzyme YjjI family H4F89_RS19925 ENOG41076CZ activating enzyme H4F89_RS19930 ENOG4105EYA deoxyribonuclease H4F89_RS19935 ENOG4108NRW Phospholipase, patatin family H4F89_RS19945 ENOG4105K3G Periplasmic Protein H4F89_RS19955 ENOG4105PAD Hydrolase H4F89_RS19960 ENOG4105KEG ribosomal-protein-alanine acetyltransferase H4F89_RS19965 ENOG4108WPU DNA polymerase III subunit psi H4F89_RS19990 ENOG4105YBH Protein of unknown function (DUF1435) H4F89_RS19995 ENOG4106TD9 Diguanylate cyclase H4F89_RS20000 ENOG4108819 ferric iron reductase H4F89_RS20005 ENOG4108UIN ybak prolyl-trna synthetase associated region H4F89_RS20010 ENOG4108T94 DNA-binding transcriptional activator BglJ H4F89_RS20015 ENOG4108N8T regulatoR H4F89_RS20020 ENOG4105DWK Membrane H4F89_RS20035 ENOG4106CVF DNA replication protein H4F89_RS20040 ENOG4105RI1 glycoprotein receptor H4F89_RS20050 ENOG4105C8Q Methyl-accepting chemotaxis H4F89_RS20055 ENOG4105D22 carbon starvation protein H4F89_RS20060 ENOG4105VCD cytoplasmic protein H4F89_RS20065 ENOG4105CKI cobalamin synthesis protein H4F89_RS20070 ENOG41063TF transcriptional regulator (AraC H4F89_RS20080 ENOG4105FU6 Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease La (By similarity) H4F89_RS20100 ENOG4105C26 Dehydrogenase H4F89_RS20105 ENOG4105DNE Transposase H4F89_RS20110 ENOG41083G8 Multidrug resistance protein MdtM H4F89_RS20115 ENOG4106BRA Membrane H4F89_RS20120 ENOG4105CBP Major Facilitator H4F89_RS20125 ENOG41074DU domain protein H4F89_RS20130 ENOG4108P2H Inner membrane protein YjiG H4F89_RS20135 ENOG4105DYB Isoaspartyl dipeptidase H4F89_RS20140 ENOG4107YNJ LysR family Transcriptional regulator H4F89_RS20155 ENOG4105C31 Tryptophanyl-tRNA synthetase H4F89_RS20160 ENOG4105C6F GntR Family Transcriptional Regulator H4F89_RS20185 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB H4F89_RS20190 ENOG4105ETZ PTS System H4F89_RS20195 ENOG4105F3R pts system mannose fructose sorbose family iid H4F89_RS20220 ENOG4106AM8 polysaccharide lyase family 8 H4F89_RS20235 ENOG4105KZM cytoplasmic protein H4F89_RS20245 ENOG4105DTA methyltransferase H4F89_RS20275 ENOG4107U53 septum site-determining protein minD H4F89_RS20285 ENOG4105CDU Replicative dna helicase H4F89_RS20490 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 H4F89_RS20525 ENOG4105DZR Type I site-specific deoxyribonuclease H4F89_RS20575 ENOG4105DQ4 alcohol dehydrogenase H4F89_RS20580 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H4F89_RS20585 ENOG4105CPQ Dehydrogenase H4F89_RS20590 ENOG4105CHR reductase H4F89_RS20595 ENOG4105C6Z Gluconate H4F89_RS20600 ENOG4105K2J Transcriptional regulator H4F89_RS20605 ENOG4105D7A ATP-binding protein H4F89_RS20610 ENOG4108K5H permease YjgP YjgQ family protein H4F89_RS20615 ENOG4108M8S permease YjgP YjgQ family protein H4F89_RS20625 ENOG4105MYG DNA polymerase iii, chi subunit H4F89_RS20630 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H4F89_RS20635 ENOG4108MJ3 acetyltransferase H4F89_RS20640 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase H4F89_RS20645 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) H4F89_RS20650 ENOG4105DBV ornithine carbamoyltransferase H4F89_RS20655 ENOG4105XEP YhcH YjgK YiaL family protein H4F89_RS20660 ENOG4105CEU Arginine dihydrolase H4F89_RS20670 ENOG4105DBV ornithine carbamoyltransferase H4F89_RS20675 ENOG4105CSX c4-dicarboxylate anaerobic carrier H4F89_RS20680 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) H4F89_RS20690 ENOG41077AM PyrBI operon attenuator H4F89_RS20705 ENOG4105KME endoribonuclease L-psp H4F89_RS20720 ENOG4105D4X repressor H4F89_RS20725 ENOG4105C5Y PTS System H4F89_RS20730 ENOG4105CG3 alpha amylase, catalytic region H4F89_RS20735 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase H4F89_RS20740 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) H4F89_RS20755 ENOG4105EMD TRANSCRIPTIONal H4F89_RS20770 ENOG41069H0 dihydroorotase EC 3.5.2.3 H4F89_RS20800 ENOG4108XVM Cytochrome b(562) H4F89_RS20805 ENOG4105CMS peptidase U62, modulator of DNA gyrase H4F89_RS20850 ENOG4105DFU Cell wall formation (By similarity) H4F89_RS20855 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 H4F89_RS20860 ENOG4105C8Q Methyl-accepting chemotaxis H4F89_RS20875 ENOG4105F0N pyrophosphate phospho-hydrolase H4F89_RS20880 ENOG4108ZHD aig2 family H4F89_RS20895 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H4F89_RS20900 ENOG4105C37 (CBS) domain H4F89_RS20905 ENOG41061GZ Protein of unknown function (DUF1107) H4F89_RS20910 ENOG4108UUE Transcriptional regulator H4F89_RS20915 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase H4F89_RS20920 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic H4F89_RS20925 ENOG4105KVH Transcriptional regulator H4F89_RS20930 ENOG4105ECR NmrA family H4F89_RS20935 ENOG4105DXC membrane H4F89_RS20950 ENOG4108V1T peptidylprolyl cis-trans isomerase H4F89_RS20955 ENOG4105FHY Opacity-associated protein A H4F89_RS20965 ENOG4105K9Q Binds to the 23S rRNA (By similarity) H4F89_RS20970 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H4F89_RS20975 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) H4F89_RS20980 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) H4F89_RS20985 ENOG4105KIT UPF0379 protein yjfY H4F89_RS21015 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC H4F89_RS21025 ENOG4105DW5 Transcriptional regulator H4F89_RS21030 ENOG4108MXZ Esterase H4F89_RS21035 ENOG4105WSB biofilm stress and motility protein A H4F89_RS21040 ENOG4105S17 UPF0379 protein yjfN H4F89_RS21045 ENOG4105CSU acyl-Coa dehydrogenase H4F89_RS21065 ENOG4105C2N RNA methyltransferase TrmH family group 3 H4F89_RS21070 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H4F89_RS21095 ENOG4105EPW hflc protein H4F89_RS21100 ENOG4107QJR hflk protein H4F89_RS21105 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H4F89_RS21110 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) H4F89_RS21125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H4F89_RS21130 ENOG4105K8N protein family UPF0079, ATPase H4F89_RS21135 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) H4F89_RS21140 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H4F89_RS21160 ENOG4106TNF Periplasmic binding protein H4F89_RS21165 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) H4F89_RS21180 ENOG4105EGS Mechanosensitive ion channel H4F89_RS21185 ENOG4107SC7 Inner membrane transporter yjeM H4F89_RS21195 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H4F89_RS21200 ENOG4105E33 succinate dehydrogenase H4F89_RS21210 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) H4F89_RS21220 ENOG4105KPY Small multidrug resistance protein H4F89_RS21230 ENOG4106BSU Entericidin B H4F89_RS21240 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H4F89_RS21245 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein H4F89_RS21255 ENOG4108ZVF (LipO)protein H4F89_RS21270 ENOG4105DVH amino acid H4F89_RS21275 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 H4F89_RS21280 ENOG4108IJ0 Aspartate ammonia-lyase H4F89_RS21285 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H4F89_RS21300 ENOG4108SIC Transcriptional regulator H4F89_RS21330 ENOG4108N8T regulatoR H4F89_RS21335 ENOG4105BZ1 (ABC) transporter H4F89_RS21370 ENOG4108ZK4 sdia-regulated domain-containing protein H4F89_RS21385 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H4F89_RS21390 ENOG4108MRH transcriptional regulatory protein H4F89_RS21395 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H4F89_RS21400 ENOG4107GFK fumarate H4F89_RS21405 ENOG4105CT4 transporter H4F89_RS21410 ENOG4105F8D glycoside hydrolase family 4 H4F89_RS21415 ENOG4108K2B transcriptional regulator H4F89_RS21420 ENOG4105CXN decarboxylase H4F89_RS21425 ENOG4106ZGR Transcriptional regulator H4F89_RS21430 ENOG4105D5Q Arginine ornithine antiporter H4F89_RS21435 ENOG4105DIJ Phosphoethanolamine transferase H4F89_RS21440 ENOG4105XJC Two component transcriptional regulator (Winged helix family H4F89_RS21445 ENOG4105ECM Sensor protein basS pmrB H4F89_RS21455 ENOG4105CSH Transporter H4F89_RS21460 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA H4F89_RS21465 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase H4F89_RS21470 ENOG4105D5T phosphonate abc transporter H4F89_RS21475 ENOG4105EHI Phosphonate ABC transporter, periplasmic H4F89_RS21485 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG H4F89_RS21490 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH H4F89_RS21495 ENOG4105EKV Phosphonate metabolism protein H4F89_RS21500 ENOG4105FT8 Phosphonate metabolism H4F89_RS21505 ENOG4105ENV phosphonate C-P lyase system protein PhnK H4F89_RS21510 ENOG4105HRV phosphonate c-p lyase system protein phnl H4F89_RS21515 ENOG4105FD8 phosphonate metabolism protein PhnM H4F89_RS21520 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) H4F89_RS21525 ENOG410849A acetyltransferase, (GNAT) family H4F89_RS21530 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein H4F89_RS21560 ENOG41082ND Uncharacterized protein yjcO H4F89_RS21565 ENOG4105CK2 sodium dicarboxylate symporter H4F89_RS21570 ENOG4108W0S formate-dependent nitrite reductase complex H4F89_RS21580 ENOG4108QKW cytochrome c-type biogenesis protein H4F89_RS21585 ENOG4105DVI reductase, NrfD H4F89_RS21590 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H4F89_RS21595 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit H4F89_RS21605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H4F89_RS21610 ENOG41062QD Membrane H4F89_RS21615 ENOG4107QN1 sodium solute H4F89_RS21620 ENOG41067MG lrgb family H4F89_RS21630 ENOG4105CMU LysR family (Transcriptional regulator H4F89_RS21635 ENOG4105EEQ Na H antiporter H4F89_RS21640 ENOG4105C7N Xanthine uracil vitamin C permease H4F89_RS21650 ENOG4108Z4X TRANSCRIPTIONal H4F89_RS21655 ENOG4108W3Q Transcriptional regulator H4F89_RS21660 ENOG4108M8H domain protein H4F89_RS21665 ENOG4105PMV Membrane H4F89_RS21725 ENOG4108UUM single-stranded DNA-binding protein H4F89_RS21730 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H4F89_RS21745 ENOG4105MSB protein, conserved in bacteria H4F89_RS21750 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme H4F89_RS21755 ENOG4105F0S class B acid phosphatase H4F89_RS21760 ENOG4105CGF Aromatic amino acid aminotransferase H4F89_RS21765 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H4F89_RS21770 ENOG4105CDU Replicative dna helicase H4F89_RS21775 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H4F89_RS21780 ENOG4105P4Z Phage shock protein G H4F89_RS21785 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H4F89_RS21790 ENOG4105E2A Dehydrogenase H4F89_RS21800 ENOG4105MYN Zinc uptake regulation protein H4F89_RS21805 ENOG4105VDW Csbd family H4F89_RS21815 ENOG4107R73 Mate efflux family protein H4F89_RS21820 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) H4F89_RS21825 ENOG41080IJ Diacylglycerol kinase H4F89_RS21845 ENOG4107W52 maltose operon periplasmic protein H4F89_RS21855 ENOG4108IJ9 (ABC) transporter H4F89_RS21860 ENOG4107FKK extracellular solute-binding protein family 1 H4F89_RS21865 ENOG4105D56 permease protein H4F89_RS21870 ENOG4105EG2 ABC transporter, permease H4F89_RS21875 ENOG4107QNK )-transporter H4F89_RS21880 ENOG4108VY7 phosphate-starvation-inducible protein PsiE H4F89_RS21885 ENOG4105E3R (LipO)protein H4F89_RS21890 ENOG4108Q9C Periplasmic Protein H4F89_RS21895 ENOG4108MDC (LipO)protein H4F89_RS21910 ENOG4105CFH Aspartokinase H4F89_RS21920 ENOG4108ZR5 Conserved Protein H4F89_RS21925 ENOG4105FE9 pseudouridine synthase H4F89_RS21930 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme H4F89_RS21945 ENOG4105EAM Na Pi-cotransporter H4F89_RS21950 ENOG4105C3R Methionine synthase H4F89_RS21960 ENOG41069M3 Transcriptional regulator H4F89_RS21975 ENOG4108I9X Isocitrate lyase H4F89_RS21980 ENOG4107QP3 malate synthase g H4F89_RS21990 ENOG4105K5X acetyltransferase H4F89_RS22020 ENOG4105C12 Phosphoribosylglycinamide synthetase H4F89_RS22025 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H4F89_RS22030 ENOG4105BZU Histidine kinase H4F89_RS22040 ENOG4108T8B Protein of unknown function (DUF1481) H4F89_RS22050 ENOG4105R2J Conserved Protein H4F89_RS22055 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) H4F89_RS22070 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) H4F89_RS22075 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) H4F89_RS22080 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H4F89_RS22085 ENOG4105D06 uba thif-type nad fad binding protein H4F89_RS22090 ENOG4105WHD thiamine biosynthesis protein ThiS H4F89_RS22095 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) H4F89_RS22100 ENOG4105D41 biosynthesis protein thiH H4F89_RS22105 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H4F89_RS22110 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H4F89_RS22120 ENOG4108VZM 50s ribosomal protein L10 H4F89_RS22135 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H4F89_RS22140 ENOG4105PM1 preprotein translocase subunit SecE H4F89_RS22145 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H4F89_RS22180 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase H4F89_RS22185 ENOG4105D4A Cell wall formation (By similarity) H4F89_RS22230 ENOG4108Y73 Membrane H4F89_RS22245 ENOG4105C5Q Transcriptional regulator H4F89_RS22275 ENOG4105DIJ Phosphoethanolamine transferase H4F89_RS22280 ENOG4106R3P AraC family transcriptional regulator H4F89_RS22290 ENOG4105DCT glycerol dehydrogenase H4F89_RS22300 ENOG4105SYT Methylenetetrahydrofolate reductase H4F89_RS22315 ENOG4105CFH Aspartokinase H4F89_RS22320 ENOG4105C28 cystathionine H4F89_RS22330 ENOG4105CT4 transporter H4F89_RS22335 ENOG4108QGT oligogalacturonate-specific porin H4F89_RS22345 ENOG4105C25 Primosomal protein n' H4F89_RS22350 ENOG4105ETE Transcriptional regulator (LacI family H4F89_RS22355 ENOG41063M6 Cell Division Protein H4F89_RS22370 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H4F89_RS22385 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H4F89_RS22395 ENOG4105CBT Fructose-1,6-bisphosphatase H4F89_RS22400 ENOG4105DP0 ferredoxin-NADP reductase H4F89_RS22405 ENOG4108VTS Membrane H4F89_RS22410 ENOG4105EBK exported protein H4F89_RS22420 ENOG4107QPK )-transporter H4F89_RS22430 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) H4F89_RS22435 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H4F89_RS22440 ENOG4105CTQ phosphohexokinase H4F89_RS22450 ENOG4105FMW periplasmic H4F89_RS22455 ENOG4105E3W Two component transcriptional regulator (Winged helix family H4F89_RS22460 ENOG4105E0F Histidine kinase H4F89_RS22465 ENOG4108RPX mosc domain containing protein H4F89_RS22470 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H4F89_RS22485 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) H4F89_RS22495 ENOG4105DKG l-rhamnose isomerase H4F89_RS22505 ENOG4105C0A alcohol dehydrogenase H4F89_RS22520 ENOG4108UMN azlc family H4F89_RS22530 ENOG41064BA PTS system, fructose-specific, IIA component H4F89_RS22535 ENOG4105DM4 PTS System H4F89_RS22540 ENOG4105CN9 Peptidase m42 family protein H4F89_RS22545 ENOG4106C3V frv operon regulatory protein H4F89_RS22565 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H4F89_RS22570 ENOG4108MG3 formate dehydrogenase H4F89_RS22585 ENOG41068KX affects formate dehydrogenase-N H4F89_RS22595 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) H4F89_RS22600 ENOG4108Z3N Transcriptional regulator H4F89_RS22605 ENOG4105SUU thioesterase domain H4F89_RS22620 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 H4F89_RS22625 ENOG4105E98 transcriptional regulator DeoR family H4F89_RS22630 ENOG4108MGF sugar kinase H4F89_RS22635 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H4F89_RS22640 ENOG4105D2M Aldolase H4F89_RS22645 ENOG4107QKS N-acylglucosamine 2-epimerase H4F89_RS22650 ENOG4107WI4 Aldose-1-epimerase H4F89_RS22660 ENOG4105CJQ hydrolase, family 31 H4F89_RS22665 ENOG4105CT4 transporter H4F89_RS22670 ENOG4105CT4 transporter H4F89_RS22675 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is H4F89_RS22680 ENOG4105CI3 gtp-binding protein typa H4F89_RS22685 ENOG4105C5F glutamine synthetase H4F89_RS22690 ENOG4105CUX Signal transduction histidine kinase H4F89_RS22695 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H4F89_RS22700 ENOG4106FIY H4F89_RS22705 ENOG4105D4P Coproporphyrinogen iii oxidase H4F89_RS22710 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) H4F89_RS22725 ENOG4105C2M dna polymerase I H4F89_RS22730 ENOG4106HNH Acyl-transferase H4F89_RS22735 ENOG4108Z33 Thiol disulfide Interchange Protein H4F89_RS22745 ENOG4105PC1 Conserved Protein H4F89_RS22750 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) H4F89_RS22755 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b H4F89_RS22785 ENOG4108RR8 protoporphyrinogen oxidase H4F89_RS22790 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) H4F89_RS22795 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H4F89_RS22810 ENOG4105CHU acetyl-coa acetyltransferase H4F89_RS22815 ENOG4107QK7 reductase H4F89_RS22820 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H4F89_RS22825 ENOG4105MDZ Transcriptional activator rfaH H4F89_RS22830 ENOG4105F8V Hydrolase, tatD family H4F89_RS22835 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H4F89_RS22840 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) H4F89_RS22845 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H4F89_RS22855 ENOG4105JC1 sterol-binding domain protein H4F89_RS22865 ENOG4105CGY Dna recombination protein H4F89_RS22870 ENOG4107SXA Phosphorylase H4F89_RS22875 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) H4F89_RS22885 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) H4F89_RS22890 ENOG4105DZ2 Transcriptional regulator H4F89_RS22895 ENOG4105EMK carboxylate amino acid amine transporter H4F89_RS22900 ENOG4105DQF Hydrolase H4F89_RS22905 ENOG4108EUD Lysophospholipase H4F89_RS22910 ENOG410829K Lysine exporter protein (Lyse ygga) H4F89_RS22915 ENOG4105CCF Lysine exporter protein (Lyse ygga) H4F89_RS22920 ENOG4105C9U ATP-dependent DNA helicase RecQ H4F89_RS22925 ENOG4105HDD phospholipase H4F89_RS22930 ENOG4108VUY thioesterase Superfamily protein H4F89_RS22935 ENOG4105FR1 rard protein H4F89_RS22950 ENOG4107QUT magnesium and cobalt transport protein CorA H4F89_RS22955 ENOG4105C4R Atp-dependent dna helicase H4F89_RS22960 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant H4F89_RS22965 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F89_RS22970 ENOG4105CT0 Protein of unknown function, DUF484 H4F89_RS22980 ENOG4105S7Z (LipO)protein H4F89_RS22990 ENOG4107T0K Adenylate cyclase H4F89_RS23000 ENOG41076E6 Uroporphyrinogen-III Synthase H4F89_RS23005 ENOG4105ECF c-methyltransferase H4F89_RS23010 ENOG410601J HemY protein H4F89_RS23035 ENOG4105C85 amino acid H4F89_RS23055 ENOG4105EGZ biosynthesis protein H4F89_RS23060 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H4F89_RS23065 ENOG4108WJ1 acetyltransferase H4F89_RS23070 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H4F89_RS23075 ENOG4105C1B dTDP-glucose 4-6-dehydratase H4F89_RS23080 ENOG4108IJ1 Dehydrogenase H4F89_RS23085 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H4F89_RS23090 ENOG4105SFE lipopolysaccharide biosynthesis protein H4F89_RS23095 ENOG4105ESV Glycosyl transferase, family 4 H4F89_RS23100 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H4F89_RS23125 ENOG4105C4R Atp-dependent dna helicase H4F89_RS23130 ENOG4106Z1T Nicotinamide Mononucleotide Transporter H4F89_RS23135 ENOG4107SXA Phosphorylase H4F89_RS23145 ENOG4105KQ5 peptidylprolyl cis-trans isomerase H4F89_RS23155 ENOG4105EMY transcriptional regulator H4F89_RS23160 ENOG4105C7B Threonine dehydratase H4F89_RS23170 ENOG4105CM2 brancheD-chain amino acid aminotransferase H4F89_RS23175 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit H4F89_RS23190 ENOG4105C0P Mg chelatase subunit ChlI H4F89_RS23235 ENOG4107EJG GntR family transcriptional regulator H4F89_RS23240 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F89_RS23245 ENOG4105ETE Transcriptional regulator (LacI family H4F89_RS23250 ENOG4108RVA ribokinase H4F89_RS23255 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H4F89_RS23260 ENOG4105CNN ABC, transporter H4F89_RS23290 ENOG4105CU9 asparagine synthetase A H4F89_RS23295 ENOG4108VVK transcriptional Regulator, AsnC H4F89_RS23300 ENOG4105QTB Flavodoxin H4F89_RS23315 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation H4F89_RS23330 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H4F89_RS23350 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H4F89_RS23355 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) H4F89_RS23360 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) H4F89_RS23370 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) H4F89_RS23375 ENOG4105C8U phosphate abc transporter H4F89_RS23380 ENOG4105E2Z phosphate ABC transporter (Permease H4F89_RS23385 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H4F89_RS23395 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 H4F89_RS23400 ENOG4105C7N Xanthine uracil vitamin C permease H4F89_RS23405 ENOG4108YYH Nadph-dependent fmn reductase H4F89_RS23410 ENOG4105E8Q phosphopantetheinyl transferase H4F89_RS23425 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) H4F89_RS23435 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H4F89_RS23450 ENOG4105VG0 50S ribosomal protein l34 H4F89_RS23455 ENOG4106JVB Replication Protein H4F89_RS23605 ENOG4105C4R Atp-dependent dna helicase H4F89_RS23745 ENOG4108M24 von Willebrand factor, type A H4F89_RS23750 ENOG4108M24 von Willebrand factor, type A H4F89_RS23780 ENOG4105DAX Pfam:DUF2983 H4F89_RS23895 ENOG4105CAF HipA N-terminal domain protein H4F89_RS23930 ENOG4105VUF Transcriptional regulator H4F89_RS23955 ENOG4108X6F Transcriptional regulator MerD H4F89_RS23970 ENOG4105XIV Mercuric transport protein, periplasmic component H4F89_RS24005 ENOG4108YX2 DNA-binding protein H4F89_RS24085 ENOG4108BUD transposase H4F89_RS24125 ENOG4106JVB Replication Protein H4F89_RS24145 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H4F89_RS24230 ENOG4108BUD transposase H4F89_RS24255 ENOG4108BUD transposase H4F89_RS24270 ENOG4108BUD transposase H4F89_RS24285 ENOG4105EQR Transposase IS116 IS110 IS902 H4F89_RS24295 ENOG4108BUD transposase H4F89_RS24340 ENOG4105NNG Peripheral inner membrane phage-shock protein H4F89_RS24345 ENOG4105FM1 phage shock protein C H4F89_RS24350 ENOG4105YYT phage shock protein B H4F89_RS24355 ENOG41087YS Phage shock protein A H4F89_RS24360 ENOG4105E51 psp operon transcriptional activator H4F89_RS24370 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H4F89_RS24375 ENOG4108WTK competence damage-inducible protein H4F89_RS24390 ENOG4108YDI single-species biofilm formation on inanimate substrate H4F89_RS24395 ENOG4108J59 Extracellular solute-binding protein, family 5 H4F89_RS24400 ENOG4108EKA peptide transport system, permease H4F89_RS24455 ENOG4108BUD transposase H4F89_RS24460 ENOG4108BUD transposase H4F89_RS24535 ENOG41085W3 Transposase H4F89_RS24555 ENOG4105K4U addiction module toxin, RelE StbE family H4F89_RS24560 ENOG41074AV Hok/gef family H4F89_RS24565 ENOG4105EKQ RNA-directed DNA polymerase H4F89_RS24670 ENOG4105EQ2 LysR family Transcriptional regulator H4F89_RS24675 ENOG4108I6A alcohol dehydrogenase H4F89_RS24680 ENOG4108SUT Major Facilitator Superfamily H4F89_RS24695 ENOG4105CAU Arsenical resistance protein, ArsH H4F89_RS24700 ENOG4105KBH arsR family transcriptional regulator H4F89_RS24710 ENOG4105K89 arsenate reductase H4F89_RS24720 ENOG4105CHH sulfate transporter H4F89_RS24790 ENOG41061MD high-affinity nickel-transporter H4F89_RS24800 ENOG4105GR3 Histidine kinase H4F89_RS24810 ENOG4105DIJ Phosphoethanolamine transferase H4F89_RS24820 ENOG4108BUD transposase H4F89_RS24900 ENOG4108R0M Aminoglycoside H4F89_RS24920 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H4F89_RS24930 ENOG4108BUD transposase H4F89_RS24945 ENOG4105DFE Dna adenine methylase H4F89_RS24970 ENOG4105F2I Transposase