locus-tag	class	description
H4F89_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4F89_RS00040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H4F89_RS00045	COG2271	Major facilitator Superfamily
H4F89_RS00050	COG0561	phosphatase activity
H4F89_RS00055	COG2186	Transcriptional regulator
H4F89_RS00060	COG3734	2-keto-3-deoxy-galactonokinase
H4F89_RS00065	COG0800	Aldolase
H4F89_RS00075	COG2271	Major facilitator Superfamily
H4F89_RS00080	COG2205	protein histidine kinase activity
H4F89_RS00080	COG2198	Histidine kinase
H4F89_RS00080	COG0784	Response regulator, receiver
H4F89_RS00085	COG1879	ABC-type sugar transport system periplasmic component
H4F89_RS00090	COG0745	RESPONSE REGULATOR receiver
H4F89_RS00095	COG3005	denitrification pathway
H4F89_RS00110	COG1858	cytochrome C peroxidase
H4F89_RS00120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4F89_RS00125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4F89_RS00130	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4F89_RS00140	COG1138	Cytochrome C-type biogenesis protein
H4F89_RS00145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4F89_RS00150	COG4235	cytochrome complex assembly
H4F89_RS00150	COG3088	subunit of a heme lyase
H4F89_RS00155	COG0823	Involved in the tonB-independent uptake of proteins
H4F89_RS00160	COG5645	(Lipo)protein
H4F89_RS00170	COG0071	Belongs to the small heat shock protein (HSP20) family
H4F89_RS00185	COG2149	membrane
H4F89_RS00195	COG0641	radical SAM
H4F89_RS00205	COG2610	gluconate transmembrane transporter activity
H4F89_RS00210	COG0583	DNA-binding transcription factor activity
H4F89_RS00220	COG2814	Major facilitator Superfamily
H4F89_RS00250	COG0028	Belongs to the TPP enzyme family
H4F89_RS00255	COG0440	acetolactate synthase activity
H4F89_RS00260	COG1349	DNA-binding transcription factor activity
H4F89_RS00270	COG0738	Major facilitator superfamily
H4F89_RS00310	COG2723	6-phospho-beta-galactosidase activity
H4F89_RS00335	COG5464	transposase or invertase
H4F89_RS00345	COG1285	pathogenesis
H4F89_RS00365	COG1335	isochorismatase
H4F89_RS00375	COG3710	Transcriptional regulator
H4F89_RS00390	COG2771	luxR family
H4F89_RS00405	COG2211	Major facilitator Superfamily
H4F89_RS00410	COG1501	Belongs to the glycosyl hydrolase 31 family
H4F89_RS00415	COG2982	Protein involved in outer membrane biogenesis
H4F89_RS00420	COG2233	PERMEase
H4F89_RS00425	COG0786	glutamate:sodium symporter activity
H4F89_RS00430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4F89_RS00435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4F89_RS00440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4F89_RS00460	COG2860	membrane
H4F89_RS00470	COG0583	DNA-binding transcription factor activity
H4F89_RS00475	COG1561	YicC-like family, N-terminal region
H4F89_RS00500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4F89_RS00530	COG1519	Transferase
H4F89_RS00535	COG0859	PFAM glycosyl transferase family 9
H4F89_RS00540	COG0438	transferase activity, transferring glycosyl groups
H4F89_RS00615	COG1216	Glycosyl transferase, family 2
H4F89_RS00620	COG2861	carbohydrate metabolic process
H4F89_RS00625	COG4942	peptidase
H4F89_RS00635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4F89_RS00640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4F89_RS00660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4F89_RS00670	COG2186	Transcriptional regulator
H4F89_RS00690	COG3722	fumarate hydratase activity
H4F89_RS00700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS00700	COG2213	PTS system mannitol-specific
H4F89_RS00705	COG0625	glutathione transferase activity
H4F89_RS00715	COG3276	selenocysteine insertion sequence binding
H4F89_RS00720	COG1454	alcohol dehydrogenase
H4F89_RS00725	COG1940	carbohydrate kinase activity
H4F89_RS00730	COG1012	belongs to the aldehyde dehydrogenase family
H4F89_RS00735	COG0235	Class ii aldolase
H4F89_RS00740	COG3623	hexulose-6-phosphate isomerase
H4F89_RS00745	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H4F89_RS00750	COG1070	Carbohydrate kinase
H4F89_RS00755	COG2271	Major facilitator Superfamily
H4F89_RS00765	COG2731	YhcH YjgK YiaL family protein
H4F89_RS00775	COG1414	Transcriptional regulator
H4F89_RS00780	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4F89_RS00785	COG3977	Valine--pyruvate aminotransferase
H4F89_RS00790	COG0366	Alpha amylase catalytic
H4F89_RS00795	COG2992	FlgJ-related protein
H4F89_RS00800	COG2207	Transcriptional regulator
H4F89_RS00800	COG1609	Transcriptional regulator
H4F89_RS00810	COG1070	Carbohydrate kinase
H4F89_RS00815	COG4682	membrane
H4F89_RS00820	COG3274	enterobacterial common antigen metabolic process
H4F89_RS00845	COG1278	Cold shock
H4F89_RS00850	COG2944	sequence-specific DNA binding
H4F89_RS00865	COG2885	chlorophyll binding
H4F89_RS00870	COG0243	molybdopterin cofactor binding
H4F89_RS00875	COG0456	acetyltransferase
H4F89_RS00880	COG2818	Glycosylase
H4F89_RS00885	COG5571	outer membrane autotransporter
H4F89_RS00905	COG0747	negative chemotaxis
H4F89_RS00910	COG0601	transmembrane transport
H4F89_RS00915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4F89_RS00920	COG0444	Belongs to the ABC transporter superfamily
H4F89_RS00925	COG4608	Belongs to the ABC transporter superfamily
H4F89_RS00930	COG0814	amino acid
H4F89_RS00970	COG1215	transferase activity, transferring glycosyl groups
H4F89_RS00975	COG1215	transferase activity, transferring glycosyl groups
H4F89_RS00990	COG2200	EAL domain
H4F89_RS00990	COG2199	diguanylate cyclase activity
H4F89_RS01005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F89_RS01010	COG2200	EAL domain
H4F89_RS01015	COG2982	Protein involved in outer membrane biogenesis
H4F89_RS01020	COG0477	Major facilitator Superfamily
H4F89_RS01025	COG1295	ribonuclease BN
H4F89_RS01030	COG0583	DNA-binding transcription factor activity
H4F89_RS01035	COG2197	response regulator
H4F89_RS01055	COG2188	Transcriptional regulator
H4F89_RS01075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4F89_RS01080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4F89_RS01100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4F89_RS01105	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H4F89_RS01110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4F89_RS01115	COG0371	Dehydrogenase
H4F89_RS01125	COG0246	Mannitol dehydrogenase
H4F89_RS01130	COG1349	DNA-binding transcription factor activity
H4F89_RS01140	COG2213	PTS system mannitol-specific
H4F89_RS01140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS01155	COG1959	2 iron, 2 sulfur cluster binding
H4F89_RS01175	COG0306	phosphate transporter
H4F89_RS01180	COG2081	HI0933 family
H4F89_RS01185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4F89_RS01190	COG0842	Transport permease protein
H4F89_RS01190	COG1129	ABC transporter
H4F89_RS01195	COG0842	Transport permease protein
H4F89_RS01205	COG2091	lysine biosynthetic process via aminoadipic acid
H4F89_RS01210	COG0628	permease
H4F89_RS01225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H4F89_RS01245	COG3714	YhhN family
H4F89_RS01255	COG3776	membrane
H4F89_RS01260	COG0742	ribosomal rna small subunit methyltransferase
H4F89_RS01265	COG0552	protein localization to endoplasmic reticulum
H4F89_RS01270	COG2884	Cell division ATP-binding protein ftsE
H4F89_RS01275	COG2177	Part of the ABC transporter FtsEX involved in
H4F89_RS01340	COG0584	glycerophosphoryl diester phosphodiesterase
H4F89_RS01350	COG0405	Gamma-glutamyltransferase
H4F89_RS01355	COG1735	metal-dependent hydrolase with the TIM-barrel fold
H4F89_RS01370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F89_RS01375	COG1247	-acetyltransferase
H4F89_RS01380	COG0673	inositol 2-dehydrogenase activity
H4F89_RS01385	COG1741	Belongs to the pirin family
H4F89_RS01390	COG1609	Transcriptional regulator
H4F89_RS01395	COG3265	gluconokinase activity
H4F89_RS01400	COG2610	gluconate transmembrane transporter activity
H4F89_RS01410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4F89_RS01430	COG0058	SHG alpha-glucan phosphorylase activity
H4F89_RS01435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H4F89_RS01450	COG1349	DNA-binding transcription factor activity
H4F89_RS01460	COG0058	SHG alpha-glucan phosphorylase activity
H4F89_RS01465	COG1640	4-alpha-glucanotransferase
H4F89_RS01470	COG2610	gluconate transmembrane transporter activity
H4F89_RS01505	COG1918	ferrous iron import across plasma membrane
H4F89_RS01510	COG2183	response to ionizing radiation
H4F89_RS01515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4F89_RS01520	COG0745	RESPONSE REGULATOR receiver
H4F89_RS01535	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H4F89_RS01545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H4F89_RS01550	COG1011	Hydrolase
H4F89_RS01560	COG0494	nUDIX hydrolase
H4F89_RS01565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H4F89_RS01570	COG4972	Pilus assembly protein
H4F89_RS01575	COG3166	PFAM Fimbrial assembly family protein
H4F89_RS01590	COG4796	Type ii and iii secretion system protein
H4F89_RS01605	COG3266	domain, Protein
H4F89_RS01610	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H4F89_RS01615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4F89_RS01655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4F89_RS01690	COG1289	transmembrane transporter activity
H4F89_RS01700	COG1765	OsmC-like protein
H4F89_RS01705	COG3954	Phosphoribulokinase
H4F89_RS01715	COG0429	hydrolase of the alpha beta-hydrolase fold
H4F89_RS01750	COG0679	Auxin Efflux Carrier
H4F89_RS01760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4F89_RS01770	COG0488	(ABC) transporter
H4F89_RS01785	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H4F89_RS01790	COG1047	Peptidyl-prolyl cis-trans
H4F89_RS01800	COG0545	Peptidyl-prolyl cis-trans isomerase
H4F89_RS01805	COG2964	Protein conserved in bacteria
H4F89_RS01860	COG0051	transcription antitermination factor activity, RNA binding
H4F89_RS01885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H4F89_RS01965	COG0201	protein transport
H4F89_RS01995	COG0203	ribosomal protein L17
H4F89_RS02005	COG0789	Transcriptional regulator
H4F89_RS02010	COG3036	rescue of stalled ribosome
H4F89_RS02040	COG0758	DNA mediated transformation
H4F89_RS02050	COG0551	DNA topoisomerase type I activity
H4F89_RS02070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4F89_RS02115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4F89_RS02120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4F89_RS02125	COG1309	transcriptional regulator
H4F89_RS02140	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H4F89_RS02160	COG4145	pantothenate transmembrane transporter activity
H4F89_RS02165	COG3924	membrane
H4F89_RS02170	COG0439	Biotin carboxylase
H4F89_RS02175	COG0511	ligase activity, forming carbon-carbon bonds
H4F89_RS02190	COG0604	alcohol dehydrogenase
H4F89_RS02195	COG2200	EAL domain
H4F89_RS02195	COG2199	diguanylate cyclase activity
H4F89_RS02200	COG1077	Cell shape determining protein MreB Mrl
H4F89_RS02205	COG1792	Involved in formation and maintenance of cell shape
H4F89_RS02210	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H4F89_RS02220	COG1530	ribonuclease E activity
H4F89_RS02225	COG3164	Protein of unknown function
H4F89_RS02230	COG0312	modulator of DNA gyrase
H4F89_RS02235	COG0583	DNA-binding transcription factor activity
H4F89_RS02255	COG2732	(Barnase) inhibitor
H4F89_RS02285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4F89_RS02290	COG3105	Protein conserved in bacteria
H4F89_RS02295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4F89_RS02310	COG0625	glutathione transferase activity
H4F89_RS02315	COG2969	positive regulation of protein catabolic process
H4F89_RS02345	COG2731	YhcH YjgK YiaL family protein
H4F89_RS02350	COG3121	Chaperone
H4F89_RS02355	COG0402	S-adenosylhomocysteine deaminase activity
H4F89_RS02360	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4F89_RS02370	COG0493	'glutamate synthase
H4F89_RS02375	COG0070	glutamate synthase
H4F89_RS02375	COG0069	glutamate synthase activity
H4F89_RS02375	COG0067	glutamate synthase
H4F89_RS02380	COG1242	4 iron, 4 sulfur cluster binding
H4F89_RS02385	COG0784	Response regulator, receiver
H4F89_RS02385	COG2198	Histidine kinase
H4F89_RS02385	COG5002	protein histidine kinase activity
H4F89_RS02390	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H4F89_RS02400	COG0515	serine threonine protein kinase
H4F89_RS02405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS02425	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4F89_RS02430	COG1137	ATPase activity
H4F89_RS02435	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H4F89_RS02440	COG3117	lipopolysaccharide transmembrane transporter activity
H4F89_RS02445	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H4F89_RS02455	COG0530	calcium, potassium:sodium antiporter activity
H4F89_RS02460	COG1127	ABC transporter
H4F89_RS02465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4F89_RS02470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4F89_RS02475	COG2854	intermembrane phospholipid transfer
H4F89_RS02480	COG3113	response to antibiotic
H4F89_RS02485	COG5007	Belongs to the BolA IbaG family
H4F89_RS02495	COG3423	Transcriptional regulator
H4F89_RS02500	COG0142	geranyltranstransferase activity
H4F89_RS02515	COG0697	spore germination
H4F89_RS02520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4F89_RS02525	COG2027	D-alanyl-D-alanine carboxypeptidase
H4F89_RS02535	COG1534	Rna-binding protein
H4F89_RS02550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4F89_RS02560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4F89_RS02625	COG0513	Belongs to the DEAD box helicase family
H4F89_RS02630	COG0814	amino acid
H4F89_RS02635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F89_RS02640	COG0826	peptidase U32
H4F89_RS02645	COG0826	peptidase U32
H4F89_RS02650	COG3154	lipid carrier protein
H4F89_RS02655	COG3153	acetyltransferase
H4F89_RS02670	COG0693	protein deglycase activity
H4F89_RS02675	COG0702	epimerase
H4F89_RS02680	COG2823	Periplasmic or secreted lipoprotein
H4F89_RS02700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H4F89_RS02710	COG2222	sugar isomerase
H4F89_RS02715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4F89_RS02725	COG1349	DNA-binding transcription factor activity
H4F89_RS02730	COG2721	sulfolactate sulfo-lyase activity
H4F89_RS02740	COG2084	Dehydrogenase
H4F89_RS02755	COG3710	Transcriptional regulator
H4F89_RS02775	COG3121	Chaperone
H4F89_RS02790	COG0583	DNA-binding transcription factor activity
H4F89_RS02810	COG1882	Formate acetyltransferase
H4F89_RS02815	COG1760	l-serine dehydratase
H4F89_RS02820	COG0814	amino acid
H4F89_RS02835	COG1741	Belongs to the pirin family
H4F89_RS02840	COG0583	DNA-binding transcription factor activity
H4F89_RS02845	COG3152	Membrane
H4F89_RS02850	COG0435	Glutathione S-transferase
H4F89_RS02855	COG2259	Doxx family
H4F89_RS02865	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
H4F89_RS02870	COG4575	ribosome binding
H4F89_RS02875	COG1422	Protein of unknown function (DUF1090)
H4F89_RS02885	COG0586	Pfam SNARE associated Golgi protein
H4F89_RS02890	COG2186	Transcriptional regulator
H4F89_RS02895	COG2271	Major facilitator Superfamily
H4F89_RS02905	COG2721	sulfolactate sulfo-lyase activity
H4F89_RS02920	COG0673	inositol 2-dehydrogenase activity
H4F89_RS02925	COG1451	nucleotide metabolic process
H4F89_RS02935	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4F89_RS02935	COG1902	pentaerythritol trinitrate reductase activity
H4F89_RS02945	COG0840	transmembrane signaling receptor activity
H4F89_RS02950	COG0840	transmembrane signaling receptor activity
H4F89_RS02955	COG1695	Transcriptional regulator
H4F89_RS02960	COG2375	cellular response to nickel ion
H4F89_RS02995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H4F89_RS03010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H4F89_RS03015	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H4F89_RS03030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4F89_RS03045	COG4991	sh3 domain protein
H4F89_RS03050	COG3025	triphosphatase activity
H4F89_RS03090	COG3384	dioxygenase
H4F89_RS03095	COG0754	glutathionylspermidine amidase activity
H4F89_RS03110	COG0494	nUDIX hydrolase
H4F89_RS03115	COG3151	Protein conserved in bacteria
H4F89_RS03120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4F89_RS03125	COG3150	esterase
H4F89_RS03135	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H4F89_RS03140	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4F89_RS03145	COG0642	Histidine kinase
H4F89_RS03155	COG3111	PFAM Bacterial OB fold (BOF) protein
H4F89_RS03185	COG0471	metal ion transport
H4F89_RS03195	COG1979	alcohol dehydrogenase
H4F89_RS03200	COG2207	Transcriptional regulator
H4F89_RS03220	COG0848	biopolymer transport protein
H4F89_RS03225	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS03250	COG0840	transmembrane signaling receptor activity
H4F89_RS03260	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H4F89_RS03265	COG0437	4 iron, 4 sulfur cluster binding
H4F89_RS03270	COG5557	Pfam Polysulphide reductase, NrfD
H4F89_RS03275	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H4F89_RS03280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H4F89_RS03285	COG1773	rubredoxin
H4F89_RS03295	COG0298	carbon dioxide binding
H4F89_RS03310	COG0625	glutathione transferase activity
H4F89_RS03315	COG0754	glutathionylspermidine amidase activity
H4F89_RS03330	COG0246	Mannitol dehydrogenase
H4F89_RS03340	COG2271	Major facilitator Superfamily
H4F89_RS03355	COG3250	beta-galactosidase activity
H4F89_RS03360	COG1309	transcriptional regulator
H4F89_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
H4F89_RS03390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4F89_RS03400	COG0531	amino acid
H4F89_RS03430	COG2301	Belongs to the HpcH HpaI aldolase family
H4F89_RS03435	COG2030	dehydratase
H4F89_RS03440	COG0427	acetyl-CoA hydrolase
H4F89_RS03470	COG3423	Transcriptional regulator
H4F89_RS03500	COG0629	single-stranded DNA binding
H4F89_RS03535	COG0589	response to stress
H4F89_RS03575	COG1285	pathogenesis
H4F89_RS03580	COG1396	sequence-specific DNA binding
H4F89_RS03580	COG3800	Transcriptional regulator
H4F89_RS03610	COG3539	Fimbrial protein
H4F89_RS03615	COG3188	usher protein
H4F89_RS03620	COG3121	Chaperone
H4F89_RS03685	COG3969	phosphoadenosine phosphosulfate
H4F89_RS03690	COG1475	DNA binding
H4F89_RS03700	COG1528	Iron-storage protein
H4F89_RS03735	COG0531	amino acid
H4F89_RS03740	COG1584	GPR1 FUN34 yaaH family protein
H4F89_RS03855	COG4774	siderophore transport
H4F89_RS03860	COG4771	TonB-dependent receptor
H4F89_RS03880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4F89_RS03885	COG0803	Belongs to the bacterial solute-binding protein 9 family
H4F89_RS03915	COG2841	Protein conserved in bacteria
H4F89_RS03975	COG1811	Na channel or pump
H4F89_RS03980	COG1982	Orn Lys Arg decarboxylase major
H4F89_RS03985	COG2211	Major facilitator Superfamily
H4F89_RS04010	COG3171	Protein conserved in bacteria
H4F89_RS04020	COG0252	asparaginase activity
H4F89_RS04025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4F89_RS04040	COG0762	integral membrane protein
H4F89_RS04045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4F89_RS04050	COG2805	Type II/IV secretion system protein
H4F89_RS04075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4F89_RS04080	COG2356	endonuclease I
H4F89_RS04090	COG2814	Major facilitator Superfamily
H4F89_RS04120	COG1166	arginine decarboxylase activity
H4F89_RS04130	COG0501	Belongs to the peptidase M48B family
H4F89_RS04135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4F89_RS04140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS04145	COG2213	PTS system mannitol-specific
H4F89_RS04150	COG1063	alcohol dehydrogenase
H4F89_RS04155	COG1494	fructose-1,6-bisphosphatase
H4F89_RS04160	COG3722	fumarate hydratase activity
H4F89_RS04165	COG1072	(Pantothenic acid kinase))
H4F89_RS04170	COG1122	ATPase activity
H4F89_RS04175	COG1122	ATPase activity
H4F89_RS04205	COG0191	fructose-bisphosphate aldolase activity
H4F89_RS04210	COG0668	transmembrane transport
H4F89_RS04220	COG2968	Membrane
H4F89_RS04225	COG0583	DNA-binding transcription factor activity
H4F89_RS04230	COG0427	acetyl-CoA hydrolase
H4F89_RS04235	COG1024	Enoyl-CoA hydratase
H4F89_RS04240	COG1703	isobutyryl-CoA mutase activity
H4F89_RS04245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4F89_RS04245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4F89_RS04260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4F89_RS04265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4F89_RS04285	COG0006	proline dipeptidase activity
H4F89_RS04290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4F89_RS04295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4F89_RS04315	COG2723	6-phospho-beta-galactosidase activity
H4F89_RS04325	COG1272	protein, Hemolysin III
H4F89_RS04380	COG4942	peptidase
H4F89_RS04425	COG3539	Fimbrial protein
H4F89_RS04430	COG3188	usher protein
H4F89_RS04460	COG3468	outer membrane autotransporter barrel domain protein
H4F89_RS04480	COG0814	amino acid
H4F89_RS04495	COG0183	Belongs to the thiolase family
H4F89_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS04510	COG2814	Major facilitator Superfamily
H4F89_RS04515	COG1794	racemase activity, acting on amino acids and derivatives
H4F89_RS04520	COG0583	DNA-binding transcription factor activity
H4F89_RS04530	COG1609	Transcriptional regulator
H4F89_RS04545	COG0477	Major facilitator Superfamily
H4F89_RS04550	COG0667	Aldo Keto reductase
H4F89_RS04560	COG0861	Integral membrane protein TerC family
H4F89_RS04590	COG2165	general secretion pathway protein
H4F89_RS04595	COG4795	General secretion pathway protein
H4F89_RS04605	COG4967	type IV pilus modification protein PilV
H4F89_RS04610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H4F89_RS04620	COG1074	ATP-dependent DNA helicase activity
H4F89_RS04625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4F89_RS04635	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4F89_RS04650	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H4F89_RS04655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4F89_RS04660	COG2962	Rard protein
H4F89_RS04665	COG2166	iron-sulfur cluster assembly
H4F89_RS04670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4F89_RS04680	COG0583	DNA-binding transcription factor activity
H4F89_RS04685	COG2363	Small membrane protein
H4F89_RS04695	COG1349	DNA-binding transcription factor activity
H4F89_RS04715	COG0738	Major facilitator superfamily
H4F89_RS04720	COG0235	Class ii aldolase
H4F89_RS04725	COG1454	alcohol dehydrogenase
H4F89_RS04735	COG1760	l-serine dehydratase
H4F89_RS04740	COG0814	amino acid
H4F89_RS04745	COG1611	Belongs to the LOG family
H4F89_RS04760	COG3098	single-species biofilm formation
H4F89_RS04770	COG0716	FMN binding
H4F89_RS04775	COG2271	Major facilitator Superfamily
H4F89_RS04780	COG4948	Mandelate Racemase Muconate Lactonizing
H4F89_RS04785	COG1929	Belongs to the glycerate kinase type-1 family
H4F89_RS04790	COG2205	protein histidine kinase activity
H4F89_RS04790	COG3437	response regulator, receiver
H4F89_RS04790	COG4999	Histidine kinase
H4F89_RS04790	COG3850	Histidine kinase
H4F89_RS04800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4F89_RS04805	COG3956	TIGRFAM MazG family protein
H4F89_RS04820	COG0602	queuosine metabolic process
H4F89_RS04825	COG0321	lipoyl(octanoyl) transferase activity
H4F89_RS04825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H4F89_RS04830	COG0720	synthase
H4F89_RS04845	COG0175	sulfate reduction
H4F89_RS04855	COG1203	CRISPR-associated helicase, Cas3
H4F89_RS04870	COG1857	crispr-associated protein
H4F89_RS04885	COG1518	maintenance of DNA repeat elements
H4F89_RS04890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4F89_RS04895	COG2234	aminopeptidase activity
H4F89_RS04950	COG1388	LysM domain
H4F89_RS04950	COG4942	peptidase
H4F89_RS04965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H4F89_RS04970	COG0163	prenyltransferase activity
H4F89_RS04980	COG1349	DNA-binding transcription factor activity
H4F89_RS04985	COG2084	Dehydrogenase
H4F89_RS04995	COG0235	Class ii aldolase
H4F89_RS05000	COG3622	Belongs to the hyi family
H4F89_RS05005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4F89_RS05010	COG2610	gluconate transmembrane transporter activity
H4F89_RS05020	COG0477	Major facilitator Superfamily
H4F89_RS05040	COG2207	Transcriptional regulator
H4F89_RS05130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4F89_RS05150	COG0741	lytic transglycosylase activity
H4F89_RS05215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4F89_RS05220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4F89_RS05225	COG1121	(ABC) transporter
H4F89_RS05245	COG0309	Hydrogenase expression formation protein (HypE)
H4F89_RS05250	COG0409	Hydrogenase expression formation protein
H4F89_RS05255	COG0298	carbon dioxide binding
H4F89_RS05260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H4F89_RS05275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4F89_RS05280	COG0651	ATP synthesis coupled electron transport
H4F89_RS05285	COG0650	Formate hydrogenlyase subunit 4
H4F89_RS05290	COG3261	NADH dehydrogenase
H4F89_RS05290	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H4F89_RS05295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4F89_RS05300	COG3260	NADH ubiquinone oxidoreductase 20
H4F89_RS05310	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H4F89_RS05315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4F89_RS05320	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H4F89_RS05340	COG0517	IMP dehydrogenase activity
H4F89_RS05340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H4F89_RS05345	COG1349	DNA-binding transcription factor activity
H4F89_RS05350	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS05365	COG3732	PTS system glucitol sorbitol-specific
H4F89_RS05370	COG3730	PTS system glucitol sorbitol-specific
H4F89_RS05375	COG2951	lytic endotransglycosylase activity
H4F89_RS05380	COG1546	Belongs to the CinA family
H4F89_RS05400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H4F89_RS05430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4F89_RS05435	COG1238	metal cluster binding
H4F89_RS05450	COG2814	Major facilitator Superfamily
H4F89_RS05455	COG1566	PFAM secretion protein HlyD family protein
H4F89_RS05460	COG1846	Transcriptional regulator
H4F89_RS05465	COG2814	Major facilitator Superfamily
H4F89_RS05505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4F89_RS05515	COG4575	ribosome binding
H4F89_RS05540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4F89_RS05545	COG0640	Transcriptional regulator
H4F89_RS05550	COG0401	homolog of Blt101
H4F89_RS05555	COG1652	LysM domain
H4F89_RS05560	COG1802	Transcriptional regulator
H4F89_RS05565	COG1113	amino acid transport
H4F89_RS05570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4F89_RS05575	COG1012	belongs to the aldehyde dehydrogenase family
H4F89_RS05580	COG0579	oxidoreductase
H4F89_RS05610	COG0642	Histidine kinase
H4F89_RS05615	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
H4F89_RS05625	COG2990	Protein conserved in bacteria
H4F89_RS05640	COG2819	hydrolase of the alpha beta superfamily
H4F89_RS05695	COG3539	Fimbrial protein
H4F89_RS05700	COG3188	usher protein
H4F89_RS05705	COG3121	Chaperone
H4F89_RS05710	COG3539	Fimbrial protein
H4F89_RS05730	COG4974	Belongs to the 'phage' integrase family
H4F89_RS05800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4F89_RS05825	COG2867	negative regulation of translational initiation
H4F89_RS05840	COG0497	DNA recombination
H4F89_RS05855	COG4536	flavin adenine dinucleotide binding
H4F89_RS05860	COG4137	Cytochrome C assembly protein
H4F89_RS05865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4F89_RS05890	COG2199	diguanylate cyclase activity
H4F89_RS05905	COG0287	Prephenate dehydrogenase
H4F89_RS05905	COG1605	Chorismate mutase
H4F89_RS05915	COG0077	Prephenate dehydratase
H4F89_RS05915	COG1605	Chorismate mutase
H4F89_RS05925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4F89_RS05930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4F89_RS05945	COG0542	response to heat
H4F89_RS05975	COG0477	Major facilitator Superfamily
H4F89_RS05980	COG5544	Lipoprotein
H4F89_RS05985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4F89_RS06000	COG3118	belongs to the thioredoxin family
H4F89_RS06005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4F89_RS06020	COG0513	Belongs to the DEAD box helicase family
H4F89_RS06030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4F89_RS06055	COG3086	response to oxidative stress
H4F89_RS06115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4F89_RS06120	COG1737	Transcriptional regulator
H4F89_RS06130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4F89_RS06130	COG1263	PTS System
H4F89_RS06135	COG0560	Phosphoserine phosphatase
H4F89_RS06160	COG2205	protein histidine kinase activity
H4F89_RS06165	COG3170	Tfp pilus assembly protein FimV
H4F89_RS06170	COG2204	response regulator
H4F89_RS06175	COG0347	Belongs to the P(II) protein family
H4F89_RS06180	COG3104	oligopeptide transport
H4F89_RS06190	COG0531	amino acid
H4F89_RS06195	COG3710	Transcriptional regulator
H4F89_RS06200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4F89_RS06200	COG1017	nitric oxide dioxygenase activity
H4F89_RS06210	COG2814	Major facilitator Superfamily
H4F89_RS06215	COG3711	transcriptional antiterminator
H4F89_RS06225	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H4F89_RS06265	COG0822	iron-sulfur transferase activity
H4F89_RS06285	COG0633	Ferredoxin
H4F89_RS06290	COG2975	iron-sulfur cluster assembly
H4F89_RS06305	COG2897	thiosulfate sulfurtransferase activity
H4F89_RS06310	COG2373	Large extracellular alpha-helical protein
H4F89_RS06315	COG4953	penicillin-binding protein 1C
H4F89_RS06320	COG0243	molybdopterin cofactor binding
H4F89_RS06325	COG0437	4 iron, 4 sulfur cluster binding
H4F89_RS06365	COG2976	Protein conserved in bacteria
H4F89_RS06380	COG1645	bacterial-type flagellum-dependent swarming motility
H4F89_RS06400	COG0516	GMP reductase activity
H4F89_RS06400	COG0517	IMP dehydrogenase activity
H4F89_RS06465	COG2200	EAL domain
H4F89_RS06480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4F89_RS06495	COG2233	PERMEase
H4F89_RS06505	COG1393	Belongs to the ArsC family
H4F89_RS06515	COG0628	permease
H4F89_RS06520	COG3835	regulator
H4F89_RS06525	COG2610	gluconate transmembrane transporter activity
H4F89_RS06530	COG1929	Belongs to the glycerate kinase type-1 family
H4F89_RS06535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4F89_RS06540	COG2716	regulation of RNA biosynthetic process
H4F89_RS06545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4F89_RS06550	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H4F89_RS06560	COG2321	neutral zinc metallopeptidase
H4F89_RS06580	COG1393	Belongs to the ArsC family
H4F89_RS06590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4F89_RS06595	COG3850	Histidine kinase
H4F89_RS06600	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4F89_RS06600	COG0493	'glutamate synthase
H4F89_RS06620	COG5342	invasion associated locus B
H4F89_RS06630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4F89_RS06645	COG0641	radical SAM
H4F89_RS06760	COG2837	iron assimilation
H4F89_RS06780	COG4208	sulfate ABC transporter
H4F89_RS06825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS06850	COG3530	Putative quorum-sensing-regulated virulence factor
H4F89_RS06855	COG0385	Bile acid
H4F89_RS06860	COG0583	DNA-binding transcription factor activity
H4F89_RS06895	COG3415	Transposase
H4F89_RS06900	COG3415	Transposase
H4F89_RS06915	COG2199	diguanylate cyclase activity
H4F89_RS06915	COG2200	EAL domain
H4F89_RS06920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4F89_RS06935	COG0667	Aldo Keto reductase
H4F89_RS06940	COG3961	Belongs to the TPP enzyme family
H4F89_RS06955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4F89_RS06960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4F89_RS06965	COG0006	proline dipeptidase activity
H4F89_RS06970	COG1363	Peptidase, m42
H4F89_RS06980	COG2207	Transcriptional regulator
H4F89_RS06985	COG0436	Aminotransferase
H4F89_RS06995	COG1560	Kdo2-lipid A biosynthetic process
H4F89_RS07095	COG0582	viral genome integration into host DNA
H4F89_RS07105	COG2116	formate transmembrane transporter activity
H4F89_RS07115	COG2067	long-chain fatty acid transport protein
H4F89_RS07120	COG3691	Protein conserved in bacteria
H4F89_RS07135	COG2062	phosphohistidine phosphatase, SixA
H4F89_RS07160	COG0730	response to heat
H4F89_RS07165	COG3101	peptidyl-lysine hydroxylation
H4F89_RS07180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4F89_RS07195	COG3423	Transcriptional regulator
H4F89_RS07220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4F89_RS07230	COG0586	Pfam SNARE associated Golgi protein
H4F89_RS07240	COG0285	dihydrofolate synthase activity
H4F89_RS07245	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H4F89_RS07250	COG1286	toxin biosynthetic process
H4F89_RS07255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H4F89_RS07260	COG3829	transcription factor binding
H4F89_RS07270	COG0531	amino acid
H4F89_RS07275	COG3457	Alanine racemase
H4F89_RS07280	COG0833	amino acid
H4F89_RS07315	COG1090	epimerase
H4F89_RS07320	COG0625	glutathione transferase activity
H4F89_RS07325	COG0625	glutathione transferase activity
H4F89_RS07330	COG0622	Phosphoesterase
H4F89_RS07340	COG1609	Transcriptional regulator
H4F89_RS07345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS07355	COG3037	sugar-specific permease SgaT UlaA
H4F89_RS07360	COG3959	Transketolase, thiamine diphosphate binding domain
H4F89_RS07365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4F89_RS07370	COG1288	antiporter activity
H4F89_RS07395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4F89_RS07400	COG0490	domain, Protein
H4F89_RS07400	COG0471	metal ion transport
H4F89_RS07410	COG0436	Aminotransferase
H4F89_RS07415	COG0583	DNA-binding transcription factor activity
H4F89_RS07465	COG0839	Belongs to the complex I subunit 6 family
H4F89_RS07475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4F89_RS07480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4F89_RS07490	COG0784	Response regulator, receiver
H4F89_RS07490	COG0835	chemotaxis
H4F89_RS07500	COG2153	protein acetylation
H4F89_RS07505	COG4575	ribosome binding
H4F89_RS07510	COG1169	isochorismate synthase
H4F89_RS07600	COG5464	transposase or invertase
H4F89_RS07605	COG0247	lactate metabolic process
H4F89_RS07615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H4F89_RS07620	COG2271	Major facilitator Superfamily
H4F89_RS07625	COG0584	glycerophosphoryl diester phosphodiesterase
H4F89_RS07630	COG0583	DNA-binding transcription factor activity
H4F89_RS07635	COG2814	Major facilitator Superfamily
H4F89_RS07640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4F89_RS07675	COG0642	Histidine kinase
H4F89_RS07675	COG2198	Histidine kinase
H4F89_RS07680	COG3039	Transposase
H4F89_RS07705	COG4615	Cyclic peptide transporter
H4F89_RS07715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4F89_RS07715	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4F89_RS07720	COG3062	negative regulation of establishment of protein localization
H4F89_RS07730	COG0437	4 iron, 4 sulfur cluster binding
H4F89_RS07735	COG0348	domain, Protein
H4F89_RS07740	COG3043	anaerobic respiration
H4F89_RS07745	COG3005	denitrification pathway
H4F89_RS07755	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4F89_RS07760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4F89_RS07765	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4F89_RS07775	COG1138	Cytochrome C-type biogenesis protein
H4F89_RS07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4F89_RS07785	COG3088	subunit of a heme lyase
H4F89_RS07785	COG4235	cytochrome complex assembly
H4F89_RS07790	COG2197	response regulator
H4F89_RS07850	COG4771	TonB-dependent receptor
H4F89_RS07885	COG1061	Type III restriction enzyme res subunit
H4F89_RS07895	COG2814	Major facilitator Superfamily
H4F89_RS07905	COG4172	Belongs to the ABC transporter superfamily
H4F89_RS07910	COG4239	(ABC) transporter, permease
H4F89_RS07915	COG4174	ABC transporter (Permease)
H4F89_RS07920	COG4166	transmembrane transport
H4F89_RS07925	COG2200	EAL domain
H4F89_RS07930	COG0791	NLP P60 protein
H4F89_RS07935	COG0671	phosphoesterase, PA-phosphatase related
H4F89_RS07940	COG0523	cobalamin synthesis protein
H4F89_RS07945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4F89_RS07950	COG3005	denitrification pathway
H4F89_RS07960	COG3381	protein complex oligomerization
H4F89_RS07995	COG1105	Belongs to the carbohydrate kinase PfkB family
H4F89_RS08000	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H4F89_RS08000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4F89_RS08000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4F89_RS08010	COG2855	membrane
H4F89_RS08015	COG0583	DNA-binding transcription factor activity
H4F89_RS08020	COG0833	amino acid
H4F89_RS08025	COG4771	TonB-dependent receptor
H4F89_RS08030	COG2271	Major facilitator Superfamily
H4F89_RS08035	COG0560	Phosphoserine phosphatase
H4F89_RS08035	COG3830	Belongs to the UPF0237 family
H4F89_RS08060	COG2311	Membrane
H4F89_RS08090	COG0493	'glutamate synthase
H4F89_RS08100	COG2949	membrane
H4F89_RS08110	COG1346	cytolysis
H4F89_RS08125	COG2271	Major facilitator Superfamily
H4F89_RS08145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4F89_RS08150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4F89_RS08160	COG1538	Outer membrane efflux protein
H4F89_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS08170	COG0586	Pfam SNARE associated Golgi protein
H4F89_RS08180	COG1686	Belongs to the peptidase S11 family
H4F89_RS08185	COG0277	FAD linked oxidase domain protein
H4F89_RS08195	COG1732	Glycine betaine
H4F89_RS08200	COG1174	glycine betaine transport
H4F89_RS08205	COG1125	glycine betaine transport
H4F89_RS08210	COG1174	glycine betaine transport
H4F89_RS08225	COG3275	phosphorelay sensor kinase activity
H4F89_RS08235	COG4807	Protein conserved in bacteria
H4F89_RS08265	COG3121	Chaperone
H4F89_RS08270	COG3188	usher protein
H4F89_RS08280	COG5455	response to cobalt ion
H4F89_RS08295	COG2188	Transcriptional regulator
H4F89_RS08300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F89_RS08305	COG1397	ADP-ribosylglycohydrolase
H4F89_RS08310	COG2211	Major facilitator Superfamily
H4F89_RS08315	COG1830	Aldolase
H4F89_RS08345	COG0745	RESPONSE REGULATOR receiver
H4F89_RS08350	COG2205	protein histidine kinase activity
H4F89_RS08380	COG0443	Heat shock 70 kDa protein
H4F89_RS08385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4F89_RS08390	COG5002	protein histidine kinase activity
H4F89_RS08390	COG3447	MASE1 domain protein
H4F89_RS08390	COG5001	Diguanylate cyclase
H4F89_RS08405	COG2982	Protein involved in outer membrane biogenesis
H4F89_RS08410	COG1253	flavin adenine dinucleotide binding
H4F89_RS08430	COG0463	Glycosyl transferase, family 2
H4F89_RS08435	COG1045	serine acetyltransferase
H4F89_RS08440	COG0438	transferase activity, transferring glycosyl groups
H4F89_RS08450	COG1216	Glycosyl transferase, family 2
H4F89_RS08455	COG0110	maltose O-acetyltransferase activity
H4F89_RS08460	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H4F89_RS08465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4F89_RS08470	COG1051	belongs to the nudix hydrolase family
H4F89_RS08475	COG0297	glycogen (starch) synthase activity
H4F89_RS08490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4F89_RS08495	COG2244	polysaccharide biosynthetic process
H4F89_RS08500	COG2327	Polysaccharide pyruvyl transferase
H4F89_RS08525	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H4F89_RS08535	COG1051	belongs to the nudix hydrolase family
H4F89_RS08540	COG0662	Cupin 2, conserved barrel domain protein
H4F89_RS08540	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H4F89_RS08570	COG0463	Glycosyl transferase, family 2
H4F89_RS08620	COG0131	Imidazoleglycerol-phosphate dehydratase
H4F89_RS08620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4F89_RS08645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4F89_RS08650	COG0583	DNA-binding transcription factor activity
H4F89_RS08660	COG0531	amino acid
H4F89_RS08665	COG2925	Exonuclease
H4F89_RS08695	COG1289	transmembrane transporter activity
H4F89_RS08725	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H4F89_RS08730	COG4656	Part of a membrane complex involved in electron transport
H4F89_RS08895	COG1122	ATPase activity
H4F89_RS08945	COG3039	Transposase
H4F89_RS09025	COG2814	Major facilitator Superfamily
H4F89_RS09040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4F89_RS09040	COG0473	3-isopropylmalate dehydrogenase activity
H4F89_RS09045	COG0473	3-isopropylmalate dehydrogenase activity
H4F89_RS09045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4F89_RS09055	COG0583	DNA-binding transcription factor activity
H4F89_RS09060	COG0582	viral genome integration into host DNA
H4F89_RS09070	COG0534	Mate efflux family protein
H4F89_RS09085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4F89_RS09155	COG1418	mRNA catabolic process
H4F89_RS09160	COG0270	DNA (cytosine-5-)-methyltransferase activity
H4F89_RS09165	COG3727	T/G mismatch-specific endonuclease activity
H4F89_RS09170	COG0697	spore germination
H4F89_RS09175	COG2354	Protein conserved in bacteria
H4F89_RS09180	COG5475	Uncharacterized small protein (DUF2158)
H4F89_RS09285	COG0425	Belongs to the sulfur carrier protein TusA family
H4F89_RS09360	COG2197	response regulator
H4F89_RS09375	COG2197	response regulator
H4F89_RS09455	COG4695	Portal protein
H4F89_RS09540	COG4974	Belongs to the 'phage' integrase family
H4F89_RS09560	COG3012	SEC-C Motif Domain Protein
H4F89_RS09560	COG3318	Belongs to the UPF0149 family
H4F89_RS09565	COG0814	amino acid
H4F89_RS09575	COG1528	Iron-storage protein
H4F89_RS09595	COG1528	Iron-storage protein
H4F89_RS09700	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H4F89_RS09715	COG3102	Protein conserved in bacteria
H4F89_RS09735	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H4F89_RS09740	COG1801	Protein of unknown function DUF72
H4F89_RS09745	COG1335	isochorismatase
H4F89_RS09755	COG0494	nUDIX hydrolase
H4F89_RS09760	COG0217	transcriptional regulatory protein
H4F89_RS09780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4F89_RS09790	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H4F89_RS09795	COG0739	heme binding
H4F89_RS09800	COG1560	Kdo2-lipid A biosynthetic process
H4F89_RS09805	COG2373	Large extracellular alpha-helical protein
H4F89_RS09805	COG1388	LysM domain
H4F89_RS09805	COG4932	domain protein
H4F89_RS09820	COG1737	Transcriptional regulator
H4F89_RS09825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4F89_RS09830	COG0129	dihydroxy-acid dehydratase activity
H4F89_RS09835	COG0800	Aldolase
H4F89_RS09845	COG3141	response to X-ray
H4F89_RS09855	COG2979	Protein of unknown function (DUF533)
H4F89_RS09860	COG1770	oligopeptidase
H4F89_RS09865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4F89_RS09870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4F89_RS09880	COG2372	response to copper ion
H4F89_RS09885	COG1276	copper resistance
H4F89_RS09905	COG3039	Transposase
H4F89_RS09950	COG3021	interspecies interaction between organisms
H4F89_RS09975	COG3121	Chaperone
H4F89_RS10000	COG5562	phage envelope protein
H4F89_RS10035	COG3008	intermembrane lipid transfer
H4F89_RS10040	COG2995	paraquat-inducible protein a
H4F89_RS10045	COG1956	GAF domain-containing protein
H4F89_RS10070	COG2814	Major facilitator Superfamily
H4F89_RS10075	COG1414	Transcriptional regulator
H4F89_RS10105	COG0768	penicillin binding
H4F89_RS10110	COG2226	methyltransferase
H4F89_RS10125	COG3716	PTS system mannose fructose sorbose family IID component
H4F89_RS10130	COG3715	PTS system
H4F89_RS10135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4F89_RS10135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS10140	COG1253	flavin adenine dinucleotide binding
H4F89_RS10145	COG2200	EAL domain
H4F89_RS10150	COG1760	l-serine dehydratase
H4F89_RS10170	COG0251	oxidation-reduction process
H4F89_RS10175	COG1199	ATP-dependent helicase activity
H4F89_RS10185	COG3065	identical protein binding
H4F89_RS10195	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H4F89_RS10205	COG2894	cell division
H4F89_RS10220	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4F89_RS10260	COG2719	SpoVR family
H4F89_RS10280	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4F89_RS10305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4F89_RS10315	COG1294	oxidase, subunit
H4F89_RS10320	COG1271	oxidase subunit
H4F89_RS10325	COG1773	rubredoxin
H4F89_RS10330	COG1999	signal sequence binding
H4F89_RS10335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H4F89_RS10340	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H4F89_RS10365	COG3119	arylsulfatase activity
H4F89_RS10370	COG1349	DNA-binding transcription factor activity
H4F89_RS10380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4F89_RS10385	COG3715	PTS system
H4F89_RS10390	COG3716	PTS system mannose fructose sorbose family IID component
H4F89_RS10395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS10410	COG0641	radical SAM
H4F89_RS10415	COG3119	arylsulfatase activity
H4F89_RS10430	COG4771	TonB-dependent receptor
H4F89_RS10435	COG1021	2,3-dihydroxybenzoate-AMP ligase
H4F89_RS10455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4F89_RS10455	COG2226	methyltransferase
H4F89_RS10455	COG3433	isochorismatase activity
H4F89_RS10470	COG1132	(ABC) transporter
H4F89_RS10475	COG2814	Major facilitator Superfamily
H4F89_RS10480	COG1169	isochorismate synthase
H4F89_RS10500	COG3039	Transposase
H4F89_RS10520	COG0582	viral genome integration into host DNA
H4F89_RS10525	COG0012	GTP binding
H4F89_RS10540	COG0659	secondary active sulfate transmembrane transporter activity
H4F89_RS10595	COG0387	Pfam Sodium calcium exchanger
H4F89_RS10600	COG4572	Cation transport regulator
H4F89_RS10610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H4F89_RS10615	COG4932	domain protein
H4F89_RS10620	COG2197	response regulator
H4F89_RS10625	COG3850	Histidine kinase
H4F89_RS10630	COG2223	nitrite transmembrane transporter activity
H4F89_RS10635	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H4F89_RS10640	COG1140	nitrate reductase beta subunit
H4F89_RS10645	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H4F89_RS10650	COG2181	nitrate reductase activity
H4F89_RS10675	COG0788	formyltetrahydrofolate deformylase activity
H4F89_RS10685	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4F89_RS10690	COG0745	RESPONSE REGULATOR receiver
H4F89_RS10695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4F89_RS10710	COG1454	alcohol dehydrogenase
H4F89_RS10710	COG1012	belongs to the aldehyde dehydrogenase family
H4F89_RS10715	COG2095	MarC family integral membrane protein
H4F89_RS10745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4F89_RS10765	COG2350	Protein conserved in bacteria
H4F89_RS10790	COG0727	PFAM Uncharacterised protein family (UPF0153)
H4F89_RS10800	COG3546	catalase activity
H4F89_RS10805	COG3685	Protein conserved in bacteria
H4F89_RS10810	COG3685	Protein conserved in bacteria
H4F89_RS10815	COG3729	General stress protein
H4F89_RS10855	COG0009	L-threonylcarbamoyladenylate synthase
H4F89_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS10875	COG0616	signal peptide processing
H4F89_RS10915	COG0671	phosphoesterase, PA-phosphatase related
H4F89_RS10920	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H4F89_RS10925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H4F89_RS10945	COG1349	DNA-binding transcription factor activity
H4F89_RS10955	COG5001	Diguanylate cyclase
H4F89_RS10965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4F89_RS10965	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4F89_RS11020	COG2801	Transposase and inactivated derivatives
H4F89_RS11060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H4F89_RS11065	COG1842	Phage shock protein A
H4F89_RS11075	COG1983	PspC domain protein
H4F89_RS11085	COG0366	Alpha amylase catalytic
H4F89_RS11090	COG1653	transport
H4F89_RS11095	COG1175	transmembrane transport
H4F89_RS11100	COG0395	ABC-type sugar transport system, permease component
H4F89_RS11105	COG1063	alcohol dehydrogenase
H4F89_RS11110	COG1082	Xylose isomerase domain protein TIM barrel
H4F89_RS11115	COG0673	inositol 2-dehydrogenase activity
H4F89_RS11120	COG1554	hydrolase, family 65, central catalytic
H4F89_RS11125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4F89_RS11130	COG3842	ATPase activity
H4F89_RS11140	COG1609	Transcriptional regulator
H4F89_RS11145	COG3106	COG3106 Predicted ATPase
H4F89_RS11165	COG4948	Mandelate Racemase Muconate Lactonizing
H4F89_RS11170	COG2866	Carboxypeptidase
H4F89_RS11190	COG4166	transmembrane transport
H4F89_RS11195	COG0656	L-ascorbic acid biosynthetic process
H4F89_RS11215	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H4F89_RS11235	COG0668	transmembrane transport
H4F89_RS11240	COG3182	Iron-regulated membrane protein
H4F89_RS11260	COG2840	Smr protein MutS2
H4F89_RS11265	COG0840	transmembrane signaling receptor activity
H4F89_RS11275	COG0513	Belongs to the DEAD box helicase family
H4F89_RS11300	COG2076	Multidrug Resistance protein
H4F89_RS11310	COG1013	pyruvate-flavodoxin oxidoreductase activity
H4F89_RS11310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4F89_RS11310	COG0674	pyruvate-flavodoxin oxidoreductase activity
H4F89_RS11310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H4F89_RS11320	COG3042	response to heat
H4F89_RS11325	COG3187	Heat shock protein
H4F89_RS11330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4F89_RS11335	COG2911	Protein conserved in bacteria
H4F89_RS11345	COG3784	Protein of unknown function (DUF1318)
H4F89_RS11360	COG1643	Atp-dependent helicase
H4F89_RS11365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H4F89_RS11370	COG3038	cytochrome b561
H4F89_RS11375	COG0500	methyltransferase
H4F89_RS11385	COG0765	amino acid transport
H4F89_RS11390	COG1126	abc transporter atp-binding protein
H4F89_RS11395	COG0765	amino acid transport
H4F89_RS11400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F89_RS11430	COG0840	transmembrane signaling receptor activity
H4F89_RS11435	COG0583	DNA-binding transcription factor activity
H4F89_RS11440	COG5383	Protein conserved in bacteria
H4F89_RS11445	COG2272	Belongs to the type-B carboxylesterase lipase family
H4F89_RS11455	COG2353	YceI-like domain
H4F89_RS11460	COG1304	FMN binding
H4F89_RS11470	COG1349	DNA-binding transcription factor activity
H4F89_RS11475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4F89_RS11480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS11485	COG0434	BtpA family
H4F89_RS11490	COG3775	system Galactitol-specific IIC component
H4F89_RS11495	COG3414	Phosphotransferase system galactitol-specific IIB component
H4F89_RS11505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4F89_RS11510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4F89_RS11515	COG1275	C4-dicarboxylate transporter malic acid transport protein
H4F89_RS11520	COG0500	methyltransferase
H4F89_RS11530	COG3135	benzoate transporter
H4F89_RS11535	COG1396	sequence-specific DNA binding
H4F89_RS11540	COG0826	peptidase U32
H4F89_RS11595	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H4F89_RS11600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4F89_RS11640	COG3238	Protein conserved in bacteria
H4F89_RS11650	COG2130	NADP-dependent
H4F89_RS11655	COG1802	Transcriptional regulator
H4F89_RS11660	COG4772	TonB-dependent receptor
H4F89_RS11745	COG0437	4 iron, 4 sulfur cluster binding
H4F89_RS11750	COG2864	formate dehydrogenase
H4F89_RS11755	COG1064	alcohol dehydrogenase
H4F89_RS11775	COG1764	response to oxidative stress
H4F89_RS11805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4F89_RS11820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H4F89_RS11825	COG1757	Na H antiporter
H4F89_RS11830	COG1609	Transcriptional regulator
H4F89_RS11855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H4F89_RS11880	COG2271	Major facilitator Superfamily
H4F89_RS11885	COG1063	alcohol dehydrogenase
H4F89_RS11890	COG2186	Transcriptional regulator
H4F89_RS11900	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H4F89_RS11905	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H4F89_RS11930	COG1773	rubredoxin
H4F89_RS11965	COG3781	membrane
H4F89_RS11985	COG1012	belongs to the aldehyde dehydrogenase family
H4F89_RS11990	COG0583	DNA-binding transcription factor activity
H4F89_RS12020	COG4566	intracellular signal transduction
H4F89_RS12035	COG2814	Major facilitator Superfamily
H4F89_RS12045	COG3111	PFAM Bacterial OB fold (BOF) protein
H4F89_RS12050	COG1546	Belongs to the CinA family
H4F89_RS12055	COG3729	General stress protein
H4F89_RS12065	COG4221	oxidoreductase activity
H4F89_RS12070	COG1802	Transcriptional regulator
H4F89_RS12080	COG0246	Mannitol dehydrogenase
H4F89_RS12110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4F89_RS12135	COG0243	molybdopterin cofactor binding
H4F89_RS12140	COG0243	molybdopterin cofactor binding
H4F89_RS12145	COG0437	4 iron, 4 sulfur cluster binding
H4F89_RS12150	COG3302	dmso reductase anchor subunit
H4F89_RS12185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4F89_RS12190	COG1940	carbohydrate kinase activity
H4F89_RS12195	COG0583	DNA-binding transcription factor activity
H4F89_RS12200	COG2814	Major facilitator Superfamily
H4F89_RS12210	COG3591	Belongs to the peptidase S1B family
H4F89_RS12225	COG0628	permease
H4F89_RS12230	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H4F89_RS12235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H4F89_RS12245	COG0531	amino acid
H4F89_RS12250	COG3136	membrane protein required for alginate biosynthesis
H4F89_RS12255	COG0745	RESPONSE REGULATOR receiver
H4F89_RS12260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4F89_RS12270	COG2205	protein histidine kinase activity
H4F89_RS12295	COG5339	Protein conserved in bacteria
H4F89_RS12300	COG1609	Transcriptional regulator
H4F89_RS12305	COG1263	PTS System
H4F89_RS12305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4F89_RS12310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H4F89_RS12320	COG0673	inositol 2-dehydrogenase activity
H4F89_RS12360	COG4659	FMN binding
H4F89_RS12370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4F89_RS12380	COG0625	glutathione transferase activity
H4F89_RS12400	COG3895	Periplasmic Protein
H4F89_RS12425	COG1566	PFAM secretion protein HlyD family protein
H4F89_RS12440	COG4989	oxidoreductase activity
H4F89_RS12445	COG3313	Fe-S protein
H4F89_RS12450	COG1309	transcriptional regulator
H4F89_RS12455	COG1902	pentaerythritol trinitrate reductase activity
H4F89_RS12470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4F89_RS12475	COG0791	NLP P60 protein
H4F89_RS12495	COG0583	DNA-binding transcription factor activity
H4F89_RS12500	COG2814	Major facilitator Superfamily
H4F89_RS12505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4F89_RS12510	COG0307	riboflavin synthase, alpha
H4F89_RS12680	COG2205	protein histidine kinase activity
H4F89_RS12680	COG2198	Histidine kinase
H4F89_RS12680	COG0784	Response regulator, receiver
H4F89_RS12690	COG0789	Transcriptional regulator
H4F89_RS12695	COG3272	Protein of unknown function (DUF1722)
H4F89_RS12730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F89_RS12745	COG0531	amino acid
H4F89_RS12760	COG1376	ErfK ybiS ycfS ynhG family protein
H4F89_RS12775	COG0719	Fe-S assembly protein
H4F89_RS12780	COG0396	ATPase activity
H4F89_RS12785	COG0719	Fe-S assembly protein
H4F89_RS12790	COG0316	Belongs to the HesB IscA family
H4F89_RS12805	COG2050	protein possibly involved in aromatic compounds catabolism
H4F89_RS12810	COG0247	lactate metabolic process
H4F89_RS12810	COG0277	FAD linked oxidase domain protein
H4F89_RS12815	COG0628	permease
H4F89_RS12830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4F89_RS12830	COG0574	Belongs to the PEP-utilizing enzyme family
H4F89_RS12840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4F89_RS12845	COG4256	Hemin uptake protein
H4F89_RS12860	COG0791	NLP P60 protein
H4F89_RS12870	COG0386	Belongs to the glutathione peroxidase family
H4F89_RS13055	COG0494	nUDIX hydrolase
H4F89_RS13080	COG3646	Phage regulatory protein
H4F89_RS13110	COG0484	heat shock protein binding
H4F89_RS13145	COG0305	Participates in initiation and elongation during chromosome replication
H4F89_RS13200	COG4712	double-strand break repair protein
H4F89_RS13270	COG3137	Salt-induced outer membrane protein
H4F89_RS13275	COG1105	Belongs to the carbohydrate kinase PfkB family
H4F89_RS13285	COG3001	Fructosamine kinase
H4F89_RS13295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4F89_RS13300	COG1988	membrane-bound metal-dependent
H4F89_RS13315	COG0753	catalase activity
H4F89_RS13325	COG1486	melibiose metabolic process
H4F89_RS13330	COG2169	Transcriptional regulator
H4F89_RS13330	COG1917	Cupin 2, conserved barrel domain protein
H4F89_RS13335	COG1447	Phosphotransferase system cellobiose-specific component IIA
H4F89_RS13340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4F89_RS13345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4F89_RS13350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4F89_RS13360	COG0322	excinuclease ABC activity
H4F89_RS13365	COG3678	ATP-independent chaperone mediated protein folding
H4F89_RS13380	COG1012	belongs to the aldehyde dehydrogenase family
H4F89_RS13400	COG0494	nUDIX hydrolase
H4F89_RS13415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4F89_RS13425	COG0778	Nitroreductase
H4F89_RS13430	COG0616	signal peptide processing
H4F89_RS13435	COG0252	asparaginase activity
H4F89_RS13440	COG1335	isochorismatase
H4F89_RS13445	COG3139	Protein of unknown function (DUF1315)
H4F89_RS13465	COG0656	L-ascorbic acid biosynthetic process
H4F89_RS13470	COG0641	radical SAM
H4F89_RS13475	COG3713	MltA-interacting MipA family protein
H4F89_RS13480	COG2766	serine protein kinase
H4F89_RS13490	COG2199	diguanylate cyclase activity
H4F89_RS13495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4F89_RS13510	COG2207	Transcriptional regulator
H4F89_RS13515	COG2807	transmembrane transport
H4F89_RS13520	COG3189	MarR family transcriptional regulator
H4F89_RS13530	COG3042	response to heat
H4F89_RS13540	COG2261	transglycosylase associated protein
H4F89_RS13555	COG3615	Tellurite resistance protein tehB
H4F89_RS13565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F89_RS13570	COG1605	Chorismate mutase
H4F89_RS13580	COG0789	Transcriptional regulator
H4F89_RS13595	COG3443	Belongs to the bacterial solute-binding protein 9 family
H4F89_RS13610	COG0668	transmembrane transport
H4F89_RS13615	COG1124	(ABC) transporter
H4F89_RS13630	COG0601	transmembrane transport
H4F89_RS13645	COG3038	cytochrome b561
H4F89_RS13655	COG0071	Belongs to the small heat shock protein (HSP20) family
H4F89_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS13735	COG3039	Transposase
H4F89_RS13835	COG0582	viral genome integration into host DNA
H4F89_RS13840	COG0538	isocitrate dehydrogenase activity
H4F89_RS13865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4F89_RS13880	COG2850	peptidyl-arginine hydroxylation
H4F89_RS13900	COG1177	transmembrane transport
H4F89_RS13920	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4F89_RS13925	COG1136	(ABC) transporter
H4F89_RS13930	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4F89_RS13935	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4F89_RS13940	COG1388	LysM domain
H4F89_RS13940	COG1376	ErfK ybiS ycfS ynhG family protein
H4F89_RS13950	COG1309	transcriptional regulator
H4F89_RS13955	COG3134	Outer membrane lipoprotein
H4F89_RS13960	COG1252	NADH dehydrogenase
H4F89_RS13985	COG5633	Lipoprotein
H4F89_RS13990	COG0537	adenosine 5'-monophosphoramidase activity
H4F89_RS13995	COG4773	Receptor
H4F89_RS14005	COG0084	hydrolase, TatD family'
H4F89_RS14010	COG0470	DNA polymerase III
H4F89_RS14020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4F89_RS14025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4F89_RS14030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4F89_RS14075	COG0564	pseudouridine synthase activity
H4F89_RS14080	COG1530	ribonuclease E activity
H4F89_RS14170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4F89_RS14180	COG2999	glutathione oxidoreductase activity
H4F89_RS14215	COG3038	cytochrome b561
H4F89_RS14230	COG1560	Kdo2-lipid A biosynthetic process
H4F89_RS14245	COG5645	(Lipo)protein
H4F89_RS14250	COG2943	transferase activity, transferring hexosyl groups
H4F89_RS14265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4F89_RS14320	COG3381	protein complex oligomerization
H4F89_RS14360	COG0582	viral genome integration into host DNA
H4F89_RS14390	COG1475	DNA binding
H4F89_RS14480	COG3311	Transcriptional regulator
H4F89_RS14490	COG0582	viral genome integration into host DNA
H4F89_RS14525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4F89_RS14535	COG1045	serine acetyltransferase
H4F89_RS14540	COG2226	methyltransferase
H4F89_RS14580	COG0583	DNA-binding transcription factor activity
H4F89_RS14590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4F89_RS14610	COG1414	Transcriptional regulator
H4F89_RS14615	COG2801	Transposase and inactivated derivatives
H4F89_RS14650	COG3436	PFAM IS66 Orf2 family protein
H4F89_RS14670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H4F89_RS14680	COG0137	argininosuccinate synthase activity
H4F89_RS14715	COG0673	inositol 2-dehydrogenase activity
H4F89_RS14720	COG2814	Major facilitator Superfamily
H4F89_RS14740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4F89_RS14745	COG1737	Transcriptional regulator
H4F89_RS14750	COG1702	phosphate starvation-inducible protein PhoH
H4F89_RS14785	COG1309	transcriptional regulator
H4F89_RS14790	COG3729	General stress protein
H4F89_RS14810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4F89_RS14815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4F89_RS14815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4F89_RS14820	COG4232	protein-disulfide reductase activity
H4F89_RS14880	COG3971	2-oxopent-4-enoate hydratase activity
H4F89_RS14890	COG3384	dioxygenase
H4F89_RS14895	COG1012	belongs to the aldehyde dehydrogenase family
H4F89_RS14905	COG1846	Transcriptional regulator
H4F89_RS14910	COG2368	4-hydroxyphenylacetate
H4F89_RS14925	COG0745	RESPONSE REGULATOR receiver
H4F89_RS14930	COG2205	protein histidine kinase activity
H4F89_RS15065	COG3023	N-Acetylmuramoyl-L-alanine amidase
H4F89_RS15145	COG3646	Phage regulatory protein
H4F89_RS15160	COG1487	ribonuclease activity
H4F89_RS15225	COG0670	Belongs to the BI1 family
H4F89_RS15245	COG1881	PFAM PEBP family protein
H4F89_RS15260	COG1832	CoA-binding protein
H4F89_RS15275	COG0210	DNA helicase
H4F89_RS15280	COG3304	Inner membrane component domain
H4F89_RS15285	COG1289	transmembrane transporter activity
H4F89_RS15290	COG3070	regulator of competence-specific genes
H4F89_RS15310	COG1067	ATP-dependent peptidase activity
H4F89_RS15320	COG3130	regulation of translation
H4F89_RS15325	COG3009	Protein conserved in bacteria
H4F89_RS15330	COG3008	intermembrane lipid transfer
H4F89_RS15330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4F89_RS15335	COG2995	paraquat-inducible protein a
H4F89_RS15340	COG0488	(ABC) transporter
H4F89_RS15350	COG3217	Mosc domain protein beta barrel domain protein
H4F89_RS15350	COG0633	Ferredoxin
H4F89_RS15365	COG0308	aminopeptidase N
H4F89_RS15380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4F89_RS15390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4F89_RS15395	COG3108	Peptidase M15
H4F89_RS15400	COG2989	Protein conserved in bacteria
H4F89_RS15410	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H4F89_RS15420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4F89_RS15425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H4F89_RS15430	COG3173	Aminoglycoside phosphotransferase
H4F89_RS15445	COG3214	Protein conserved in bacteria
H4F89_RS15470	COG0539	negative regulation of cytoplasmic translation
H4F89_RS15490	COG2323	membrane
H4F89_RS15495	COG1944	ATP diphosphatase activity
H4F89_RS15500	COG2116	formate transmembrane transporter activity
H4F89_RS15505	COG1882	Formate acetyltransferase
H4F89_RS15515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H4F89_RS15520	COG0531	amino acid
H4F89_RS15530	COG1335	isochorismatase
H4F89_RS15535	COG3302	dmso reductase anchor subunit
H4F89_RS15540	COG0437	4 iron, 4 sulfur cluster binding
H4F89_RS15545	COG0243	molybdopterin cofactor binding
H4F89_RS15555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4F89_RS15575	COG0492	ferredoxin-NADP+ reductase activity
H4F89_RS15580	COG4988	ABC transporter
H4F89_RS15585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H4F89_RS15605	COG0583	DNA-binding transcription factor activity
H4F89_RS15615	COG1335	isochorismatase
H4F89_RS15630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4F89_RS15650	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H4F89_RS15660	COG0156	8-amino-7-oxononanoate synthase activity
H4F89_RS15720	COG3783	Cytochrome b(562)
H4F89_RS15735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H4F89_RS15765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4F89_RS15770	COG4227	nucleotidyltransferase activity
H4F89_RS15775	COG0582	viral genome integration into host DNA
H4F89_RS15800	COG0542	response to heat
H4F89_RS15810	COG1278	Cold shock
H4F89_RS15815	COG0577	efflux transmembrane transporter activity
H4F89_RS15815	COG1136	(ABC) transporter
H4F89_RS15820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4F89_RS15825	COG2990	Protein conserved in bacteria
H4F89_RS15830	COG3593	DNA synthesis involved in DNA repair
H4F89_RS15835	COG2431	L-lysine efflux transmembrane transporter activity
H4F89_RS15845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4F89_RS15850	COG0028	Belongs to the TPP enzyme family
H4F89_RS15855	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H4F89_RS15860	COG0702	epimerase
H4F89_RS15865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4F89_RS15870	COG3023	N-Acetylmuramoyl-L-alanine amidase
H4F89_RS15885	COG1126	abc transporter atp-binding protein
H4F89_RS15890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F89_RS15895	COG4215	(ABC) transporter
H4F89_RS15900	COG4160	amino acid transport
H4F89_RS15905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F89_RS15935	COG1177	transmembrane transport
H4F89_RS15940	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4F89_RS15945	COG3842	ATPase activity
H4F89_RS15950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4F89_RS15990	COG3226	Transcriptional regulator
H4F89_RS15995	COG0738	Major facilitator superfamily
H4F89_RS16000	COG0561	phosphatase activity
H4F89_RS16005	COG2814	Major facilitator Superfamily
H4F89_RS16010	COG0671	phosphoesterase, PA-phosphatase related
H4F89_RS16015	COG1349	DNA-binding transcription factor activity
H4F89_RS16020	COG1686	Belongs to the peptidase S11 family
H4F89_RS16025	COG0625	glutathione transferase activity
H4F89_RS16030	COG2133	pyrroloquinoline quinone binding
H4F89_RS16075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H4F89_RS16080	COG1882	Formate acetyltransferase
H4F89_RS16085	COG0561	phosphatase activity
H4F89_RS16100	COG2271	Major facilitator Superfamily
H4F89_RS16110	COG0488	(ABC) transporter
H4F89_RS16115	COG1376	ErfK ybiS ycfS ynhG family protein
H4F89_RS16120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H4F89_RS16135	COG2194	sulfuric ester hydrolase activity
H4F89_RS16140	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H4F89_RS16155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F89_RS16160	COG0765	amino acid transport
H4F89_RS16165	COG1126	abc transporter atp-binding protein
H4F89_RS16170	COG0668	transmembrane transport
H4F89_RS16180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4F89_RS16190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4F89_RS16200	COG0513	Belongs to the DEAD box helicase family
H4F89_RS16205	COG1309	transcriptional regulator
H4F89_RS16210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4F89_RS16215	COG1131	(ABC) transporter
H4F89_RS16220	COG0842	Transport permease protein
H4F89_RS16225	COG0842	Transport permease protein
H4F89_RS16235	COG3568	Endonuclease Exonuclease Phosphatase
H4F89_RS16240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4F89_RS16245	COG0392	lysyltransferase activity
H4F89_RS16250	COG0670	Belongs to the BI1 family
H4F89_RS16260	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H4F89_RS16270	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4F89_RS16320	COG1881	PFAM PEBP family protein
H4F89_RS16350	COG4677	pectinesterase activity
H4F89_RS16365	COG0561	phosphatase activity
H4F89_RS16375	COG4149	molybdate abc transporter
H4F89_RS16380	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4F89_RS16390	COG3585	molybdate ion transport
H4F89_RS16390	COG2005	Transcriptional regulator
H4F89_RS16395	COG1119	ATPase activity
H4F89_RS16415	COG2017	converts alpha-aldose to the beta-anomer
H4F89_RS16425	COG1486	melibiose metabolic process
H4F89_RS16430	COG1917	Cupin 2, conserved barrel domain protein
H4F89_RS16430	COG2169	Transcriptional regulator
H4F89_RS16435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4F89_RS16445	COG1120	ATPase activity
H4F89_RS16450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F89_RS16455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4F89_RS16510	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H4F89_RS16515	COG2885	chlorophyll binding
H4F89_RS16525	COG3064	Membrane
H4F89_RS16530	COG0848	biopolymer transport protein
H4F89_RS16535	COG0811	peptide transport
H4F89_RS16540	COG0824	Thioesterase
H4F89_RS16545	COG3790	cyd operon protein YbgE
H4F89_RS16550	COG4890	Cyd operon protein YbgT
H4F89_RS16555	COG1294	oxidase, subunit
H4F89_RS16560	COG1271	oxidase subunit
H4F89_RS16570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4F89_RS16580	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4F89_RS16585	COG0567	Dehydrogenase, E1 component
H4F89_RS16600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H4F89_RS16620	COG3180	Ammonia monooxygenase
H4F89_RS16685	COG0582	viral genome integration into host DNA
H4F89_RS16700	COG1984	allophanate hydrolase subunit 2
H4F89_RS16705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4F89_RS16750	COG2205	protein histidine kinase activity
H4F89_RS16755	COG0745	RESPONSE REGULATOR receiver
H4F89_RS16765	COG1982	Orn Lys Arg decarboxylase major
H4F89_RS16770	COG0531	amino acid
H4F89_RS16780	COG0033	Phosphoglucomutase
H4F89_RS16790	COG0596	Alpha beta hydrolase
H4F89_RS16805	COG0735	belongs to the Fur family
H4F89_RS16810	COG0583	DNA-binding transcription factor activity
H4F89_RS16815	COG1053	succinate dehydrogenase
H4F89_RS16845	COG1263	PTS System
H4F89_RS16845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4F89_RS16845	COG2190	(PTS) system
H4F89_RS16855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4F89_RS16860	COG1940	carbohydrate kinase activity
H4F89_RS16860	COG1846	Transcriptional regulator
H4F89_RS16865	COG0647	UMP catabolic process
H4F89_RS16870	COG0367	asparagine synthase
H4F89_RS16910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4F89_RS16920	COG1702	phosphate starvation-inducible protein PhoH
H4F89_RS16945	COG0765	amino acid transport
H4F89_RS16950	COG0765	amino acid transport
H4F89_RS16955	COG1126	abc transporter atp-binding protein
H4F89_RS16965	COG2888	peptidyl-tyrosine sulfation
H4F89_RS16985	COG1466	dna polymerase III delta subunit
H4F89_RS16995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4F89_RS17005	COG0799	negative regulation of ribosome biogenesis
H4F89_RS17015	COG0768	penicillin binding
H4F89_RS17020	COG0772	Belongs to the SEDS family
H4F89_RS17025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4F89_RS17030	COG1686	Belongs to the peptidase S11 family
H4F89_RS17045	COG0583	DNA-binding transcription factor activity
H4F89_RS17060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4F89_RS17080	COG3069	C4-dicarboxylate transmembrane transporter activity
H4F89_RS17085	COG4565	transcriptional regulatory protein
H4F89_RS17090	COG3290	protein histidine kinase activity
H4F89_RS17095	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H4F89_RS17105	COG2301	Belongs to the HpcH HpaI aldolase family
H4F89_RS17110	COG3051	citrate lyase alpha subunit
H4F89_RS17125	COG0471	metal ion transport
H4F89_RS17130	COG3719	Belongs to the RNase T2 family
H4F89_RS17135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4F89_RS17140	COG1063	alcohol dehydrogenase
H4F89_RS17160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4F89_RS17165	COG0583	DNA-binding transcription factor activity
H4F89_RS17170	COG3969	phosphoadenosine phosphosulfate
H4F89_RS17175	COG1475	DNA binding
H4F89_RS17180	COG0436	Aminotransferase
H4F89_RS17185	COG0371	Dehydrogenase
H4F89_RS17190	COG2879	small protein
H4F89_RS17195	COG1966	Carbon starvation protein
H4F89_RS17205	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS17210	COG3433	isochorismatase activity
H4F89_RS17210	COG1535	isochorismatase
H4F89_RS17215	COG1021	2,3-dihydroxybenzoate-AMP ligase
H4F89_RS17220	COG1169	isochorismate synthase
H4F89_RS17225	COG4592	Periplasmic binding protein
H4F89_RS17235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F89_RS17240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F89_RS17245	COG1120	ATPase activity
H4F89_RS17250	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H4F89_RS17255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4F89_RS17255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H4F89_RS17260	COG3251	PFAM MbtH domain protein
H4F89_RS17265	COG2382	esterase
H4F89_RS17270	COG4771	TonB-dependent receptor
H4F89_RS17275	COG2977	Belongs to the P-Pant transferase superfamily
H4F89_RS17300	COG2315	Protein conserved in bacteria
H4F89_RS17310	COG2188	Transcriptional regulator
H4F89_RS17320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4F89_RS17325	COG1447	Phosphotransferase system cellobiose-specific component IIA
H4F89_RS17335	COG2723	6-phospho-beta-galactosidase activity
H4F89_RS17345	COG0668	transmembrane transport
H4F89_RS17350	COG1113	amino acid transport
H4F89_RS17360	COG3059	membrane
H4F89_RS17370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4F89_RS17375	COG2207	Transcriptional regulator
H4F89_RS17460	COG2501	S4 domain
H4F89_RS17470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4F89_RS17480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H4F89_RS17485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4F89_RS17505	COG1464	Belongs to the NlpA lipoprotein family
H4F89_RS17515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H4F89_RS17520	COG4181	ATPase activity
H4F89_RS17525	COG2755	lipolytic protein G-D-S-L family
H4F89_RS17530	COG0300	oxidoreductase activity
H4F89_RS17535	COG3118	belongs to the thioredoxin family
H4F89_RS17540	COG0390	transport system, permease component
H4F89_RS17545	COG4619	ABC transporter
H4F89_RS17550	COG0330	HflC and HflK could
H4F89_RS17555	COG1585	Membrane protein implicated in regulation of membrane protease activity
H4F89_RS17565	COG2217	Heavy metal translocating P-type atpase
H4F89_RS17570	COG3735	TraB family
H4F89_RS17585	COG2223	nitrite transmembrane transporter activity
H4F89_RS17590	COG4651	solute:proton antiporter activity
H4F89_RS17590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4F89_RS17595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F89_RS17640	COG2832	Protein of unknown function (DUF454)
H4F89_RS17645	COG3923	Primosomal replication protein n
H4F89_RS17665	COG1196	nuclear chromosome segregation
H4F89_RS17665	COG3264	Mechanosensitive ion channel
H4F89_RS17670	COG1309	transcriptional regulator
H4F89_RS17675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4F89_RS17680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4F89_RS17695	COG0110	maltose O-acetyltransferase activity
H4F89_RS17715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4F89_RS17725	COG3695	enzyme binding
H4F89_RS17730	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H4F89_RS17735	COG1946	Acyl-CoA thioesterase
H4F89_RS17740	COG0004	ammonium transporteR
H4F89_RS17745	COG0347	Belongs to the P(II) protein family
H4F89_RS17750	COG1132	(ABC) transporter
H4F89_RS17755	COG1132	(ABC) transporter
H4F89_RS17760	COG1522	sequence-specific DNA binding
H4F89_RS17770	COG0561	phosphatase activity
H4F89_RS17775	COG4533	DNA binding
H4F89_RS17785	COG0824	Thioesterase
H4F89_RS17790	COG1555	photosystem II stabilization
H4F89_RS17795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4F89_RS17805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4F89_RS17825	COG0271	Belongs to the BolA IbaG family
H4F89_RS17830	COG3056	Lipoprotein
H4F89_RS17835	COG2223	nitrite transmembrane transporter activity
H4F89_RS17840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4F89_RS17845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4F89_RS17850	COG1845	cytochrome c oxidase, subunit III
H4F89_RS17855	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4F89_RS17870	COG2814	Major facilitator Superfamily
H4F89_RS17905	COG0142	geranyltranstransferase activity
H4F89_RS17915	COG0667	Aldo Keto reductase
H4F89_RS17920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4F89_RS17940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4F89_RS17940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4F89_RS17950	COG4238	major outer membrane lipoprotein
H4F89_RS17965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4F89_RS17975	COG1862	Preprotein translocase
H4F89_RS17995	COG0450	alkyl hydroperoxide reductase
H4F89_RS18000	COG0366	Alpha amylase catalytic
H4F89_RS18015	COG5002	protein histidine kinase activity
H4F89_RS18025	COG0420	3'-5' exonuclease activity
H4F89_RS18030	COG0419	ATPase involved in DNA repair
H4F89_RS18035	COG2814	Major facilitator Superfamily
H4F89_RS18040	COG1940	carbohydrate kinase activity
H4F89_RS18055	COG4126	flavin adenine dinucleotide binding
H4F89_RS18075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4F89_RS18080	COG3706	GGDEF domain
H4F89_RS18125	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H4F89_RS18130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4F89_RS18145	COG0113	porphobilinogen synthase activity
H4F89_RS18180	COG1280	lysine exporter protein (LysE YggA)
H4F89_RS18200	COG1294	oxidase, subunit
H4F89_RS18205	COG1271	oxidase subunit
H4F89_RS18225	COG2814	Major facilitator Superfamily
H4F89_RS18265	COG2200	EAL domain
H4F89_RS18280	COG3539	Fimbrial protein
H4F89_RS18285	COG3121	Chaperone
H4F89_RS18290	COG3188	usher protein
H4F89_RS18385	COG0582	viral genome integration into host DNA
H4F89_RS18390	COG0582	viral genome integration into host DNA
H4F89_RS18410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H4F89_RS18420	COG1061	Type III restriction enzyme res subunit
H4F89_RS18430	COG3596	GTP binding
H4F89_RS18435	COG2378	regulation of single-species biofilm formation
H4F89_RS18445	COG2378	regulation of single-species biofilm formation
H4F89_RS18490	COG2003	Belongs to the UPF0758 family
H4F89_RS18575	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4F89_RS18585	COG3034	peptidoglycan biosynthetic process
H4F89_RS18590	COG0121	glutamine amidotransferase
H4F89_RS18605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4F89_RS18645	COG2226	methyltransferase
H4F89_RS18655	COG1388	LysM domain
H4F89_RS18655	COG0741	lytic transglycosylase activity
H4F89_RS18660	COG2226	methyltransferase
H4F89_RS18670	COG0583	DNA-binding transcription factor activity
H4F89_RS18705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4F89_RS18730	COG1720	tRNA m6t6A37 methyltransferase activity
H4F89_RS18740	COG3015	lipoprotein NlpE involved in copper resistance
H4F89_RS18745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H4F89_RS18760	COG4568	rho-dependent transcription termination
H4F89_RS18770	COG0346	lactoylglutathione lyase activity
H4F89_RS18835	COG0575	Belongs to the CDS family
H4F89_RS18885	COG0477	Major facilitator Superfamily
H4F89_RS18895	COG3835	regulator
H4F89_RS18920	COG2860	membrane
H4F89_RS18945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4F89_RS18950	COG1120	ATPase activity
H4F89_RS18955	COG4774	siderophore transport
H4F89_RS18960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4F89_RS18965	COG1643	Atp-dependent helicase
H4F89_RS18970	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H4F89_RS18975	COG1489	DNA binding
H4F89_RS18985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4F89_RS18990	COG0617	tRNA 3'-terminal CCA addition
H4F89_RS18995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4F89_RS19010	COG5464	transposase or invertase
H4F89_RS19020	COG0726	polysaccharide deacetylase
H4F89_RS19025	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS19030	COG0842	Transport permease protein
H4F89_RS19035	COG1131	(ABC) transporter
H4F89_RS19040	COG0288	reversible hydration of carbon dioxide
H4F89_RS19050	COG4993	Dehydrogenase
H4F89_RS19055	COG2132	Multicopper oxidase
H4F89_RS19075	COG0110	maltose O-acetyltransferase activity
H4F89_RS19080	COG2223	nitrite transmembrane transporter activity
H4F89_RS19090	COG1609	Transcriptional regulator
H4F89_RS19095	COG3112	Uncharacterised protein family (UPF0231)
H4F89_RS19105	COG3064	Membrane
H4F89_RS19120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4F89_RS19125	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4F89_RS19130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H4F89_RS19145	COG2211	Major facilitator Superfamily
H4F89_RS19150	COG3940	Belongs to the glycosyl hydrolase 43 family
H4F89_RS19155	COG3725	Membrane protein required for beta-lactamase induction
H4F89_RS19170	COG4969	Belongs to the N-Me-Phe pilin family
H4F89_RS19175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4F89_RS19180	COG1459	type II secretion system
H4F89_RS19205	COG0494	nUDIX hydrolase
H4F89_RS19230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4F89_RS19235	COG0849	cell division
H4F89_RS19260	COG0772	Belongs to the SEDS family
H4F89_RS19275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4F89_RS19285	COG0768	penicillin binding
H4F89_RS19350	COG2814	Major facilitator Superfamily
H4F89_RS19380	COG0586	Pfam SNARE associated Golgi protein
H4F89_RS19410	COG0417	DNA replication proofreading
H4F89_RS19480	COG2271	Major facilitator Superfamily
H4F89_RS19490	COG0644	oxidoreductase
H4F89_RS19530	COG3119	arylsulfatase activity
H4F89_RS19585	COG1047	Peptidyl-prolyl cis-trans
H4F89_RS19600	COG0196	riboflavin kinase activity
H4F89_RS19615	COG0583	DNA-binding transcription factor activity
H4F89_RS19630	COG3119	arylsulfatase activity
H4F89_RS19670	COG3121	Chaperone
H4F89_RS19675	COG3539	Fimbrial protein
H4F89_RS19690	COG3188	usher protein
H4F89_RS19755	COG4735	regulation of single-species biofilm formation
H4F89_RS19760	COG1584	GPR1 FUN34 yaaH family protein
H4F89_RS19765	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4F89_RS19780	COG1115	amino acid carrier protein
H4F89_RS19790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4F89_RS19800	COG0460	homoserine dehydrogenase
H4F89_RS19800	COG0527	aspartate kinase activity
H4F89_RS19810	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H4F89_RS19820	COG0745	RESPONSE REGULATOR receiver
H4F89_RS19840	COG3045	CreA protein
H4F89_RS19845	COG3708	Transcriptional regulator
H4F89_RS19845	COG2207	Transcriptional regulator
H4F89_RS19870	COG0488	(ABC) transporter
H4F89_RS19885	COG0560	Phosphoserine phosphatase
H4F89_RS19890	COG3726	membrane protein affecting hemolysin expression
H4F89_RS19920	COG1328	CTP reductase activity
H4F89_RS19925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H4F89_RS19930	COG0084	hydrolase, TatD family'
H4F89_RS19935	COG4667	esterase of the alpha-beta hydrolase superfamily
H4F89_RS19945	COG2823	Periplasmic or secreted lipoprotein
H4F89_RS19955	COG1011	Hydrolase
H4F89_RS19965	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
H4F89_RS19995	COG3706	GGDEF domain
H4F89_RS20000	COG4114	ferric iron reductase
H4F89_RS20005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4F89_RS20010	COG2197	response regulator
H4F89_RS20015	COG2197	response regulator
H4F89_RS20020	COG2966	Psort location CytoplasmicMembrane, score
H4F89_RS20035	COG1484	DNA-dependent DNA replication
H4F89_RS20050	COG0840	transmembrane signaling receptor activity
H4F89_RS20055	COG1966	Carbon starvation protein
H4F89_RS20060	COG2879	small protein
H4F89_RS20065	COG0523	cobalamin synthesis protein
H4F89_RS20100	COG1012	belongs to the aldehyde dehydrogenase family
H4F89_RS20105	COG5464	transposase or invertase
H4F89_RS20115	COG2733	membrane
H4F89_RS20120	COG0477	Major facilitator Superfamily
H4F89_RS20125	COG3366	ferrous iron transmembrane transporter activity
H4F89_RS20130	COG0700	Nucleoside recognition
H4F89_RS20135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4F89_RS20140	COG0583	DNA-binding transcription factor activity
H4F89_RS20155	COG0180	Tryptophanyl-tRNA synthetase
H4F89_RS20160	COG2186	Transcriptional regulator
H4F89_RS20165	COG0412	Dienelactone hydrolase
H4F89_RS20185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4F89_RS20190	COG3715	PTS system
H4F89_RS20195	COG3716	PTS system mannose fructose sorbose family IID component
H4F89_RS20220	COG5492	domain, Protein
H4F89_RS20245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H4F89_RS20275	COG2894	cell division
H4F89_RS20285	COG0305	Participates in initiation and elongation during chromosome replication
H4F89_RS20490	COG1401	restriction endodeoxyribonuclease activity
H4F89_RS20525	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H4F89_RS20555	COG4227	nucleotidyltransferase activity
H4F89_RS20575	COG1064	alcohol dehydrogenase
H4F89_RS20580	COG3265	gluconokinase activity
H4F89_RS20585	COG1063	alcohol dehydrogenase
H4F89_RS20590	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS20595	COG2610	gluconate transmembrane transporter activity
H4F89_RS20600	COG1609	Transcriptional regulator
H4F89_RS20605	COG0433	COG0433 Predicted ATPase
H4F89_RS20610	COG0795	lipopolysaccharide-transporting ATPase activity
H4F89_RS20615	COG0795	lipopolysaccharide-transporting ATPase activity
H4F89_RS20625	COG2927	DNA polymerase III (CHI subunit)
H4F89_RS20655	COG2731	YhcH YjgK YiaL family protein
H4F89_RS20665	COG0549	Belongs to the carbamate kinase family
H4F89_RS20675	COG1288	antiporter activity
H4F89_RS20680	COG1438	arginine binding
H4F89_RS20725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4F89_RS20725	COG1263	PTS System
H4F89_RS20730	COG0366	Alpha amylase catalytic
H4F89_RS20740	COG0602	queuosine metabolic process
H4F89_RS20750	COG3077	Addiction module antitoxin, RelB DinJ family
H4F89_RS20755	COG3711	transcriptional antiterminator
H4F89_RS20755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS20770	COG3964	amidohydrolase
H4F89_RS20805	COG0312	modulator of DNA gyrase
H4F89_RS20850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4F89_RS20860	COG0840	transmembrane signaling receptor activity
H4F89_RS20880	COG2105	PFAM AIG2 family protein
H4F89_RS20900	COG1253	flavin adenine dinucleotide binding
H4F89_RS20910	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H4F89_RS20925	COG1733	regulation of RNA biosynthetic process
H4F89_RS20930	COG0702	epimerase
H4F89_RS20935	COG0697	spore germination
H4F89_RS20945	COG1113	amino acid transport
H4F89_RS20950	COG0545	Peptidyl-prolyl cis-trans isomerase
H4F89_RS20955	COG3061	Opacity-associated protein A
H4F89_RS20970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4F89_RS21030	COG1073	alpha beta
H4F89_RS21035	COG3650	response to hydrogen peroxide
H4F89_RS21045	COG1960	acyl-CoA dehydrogenase activity
H4F89_RS21070	COG0557	exoribonuclease II activity
H4F89_RS21090	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H4F89_RS21095	COG0330	HflC and HflK could
H4F89_RS21100	COG0330	HflC and HflK could
H4F89_RS21105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4F89_RS21130	COG0802	atpase or kinase
H4F89_RS21135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4F89_RS21135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4F89_RS21160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F89_RS21180	COG1511	domain protein
H4F89_RS21180	COG3264	Mechanosensitive ion channel
H4F89_RS21195	COG1053	succinate dehydrogenase
H4F89_RS21200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4F89_RS21230	COG5510	response to toxic substance
H4F89_RS21270	COG0531	amino acid
H4F89_RS21275	COG3030	protein affecting phage T7 exclusion by the F plasmid
H4F89_RS21280	COG1027	Aspartate ammonia-lyase
H4F89_RS21285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H4F89_RS21300	COG1309	transcriptional regulator
H4F89_RS21330	COG2197	response regulator
H4F89_RS21335	COG1132	(ABC) transporter
H4F89_RS21385	COG3290	protein histidine kinase activity
H4F89_RS21390	COG4565	transcriptional regulatory protein
H4F89_RS21395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H4F89_RS21400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H4F89_RS21400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H4F89_RS21415	COG2169	Transcriptional regulator
H4F89_RS21420	COG1982	Orn Lys Arg decarboxylase major
H4F89_RS21425	COG2207	Transcriptional regulator
H4F89_RS21430	COG0531	amino acid
H4F89_RS21460	COG2824	Alkylphosphonate utilization operon protein PhnA
H4F89_RS21465	COG2764	glyoxalase bleomycin resistance protein dioxygenase
H4F89_RS21475	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H4F89_RS21480	COG3639	organic phosphonate transmembrane transporter activity
H4F89_RS21485	COG3624	Phosphonate C-P lyase system protein PhnG
H4F89_RS21490	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H4F89_RS21495	COG3626	phosphonate metabolism
H4F89_RS21500	COG3627	carbon phosphorus lyase activity
H4F89_RS21505	COG4107	phosphonate C-P lyase system protein PhnK
H4F89_RS21510	COG4778	phosphonate C-P lyase system protein PhnL
H4F89_RS21515	COG3454	Phosphonate metabolism
H4F89_RS21525	COG0456	acetyltransferase
H4F89_RS21530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H4F89_RS21555	COG2801	Transposase and inactivated derivatives
H4F89_RS21560	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H4F89_RS21565	COG1301	dicarboxylic acid transport
H4F89_RS21570	COG4235	cytochrome complex assembly
H4F89_RS21575	COG3088	subunit of a heme lyase
H4F89_RS21580	COG1138	Cytochrome C-type biogenesis protein
H4F89_RS21585	COG3301	Polysulphide reductase, NrfD
H4F89_RS21590	COG0437	4 iron, 4 sulfur cluster binding
H4F89_RS21595	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H4F89_RS21605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4F89_RS21610	COG3162	membrane
H4F89_RS21620	COG1346	cytolysis
H4F89_RS21625	COG1380	Effector of murein hydrolase LrgA
H4F89_RS21630	COG0583	DNA-binding transcription factor activity
H4F89_RS21635	COG0025	NhaP-type Na H and K H
H4F89_RS21640	COG2252	PERMEase
H4F89_RS21660	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4F89_RS21675	COG2207	Transcriptional regulator
H4F89_RS21745	COG2315	Protein conserved in bacteria
H4F89_RS21755	COG3700	Belongs to the class B bacterial acid phosphatase family
H4F89_RS21785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4F89_RS21790	COG1063	alcohol dehydrogenase
H4F89_RS21800	COG0735	belongs to the Fur family
H4F89_RS21815	COG0534	Mate efflux family protein
H4F89_RS21825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4F89_RS21870	COG3833	ABC-type maltose transport systems, permease component
H4F89_RS21875	COG2814	Major facilitator Superfamily
H4F89_RS21875	COG0477	Major facilitator Superfamily
H4F89_RS21885	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4F89_RS21910	COG0527	aspartate kinase activity
H4F89_RS21925	COG1187	pseudouridine synthase activity
H4F89_RS21930	COG3122	Protein conserved in bacteria
H4F89_RS21980	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4F89_RS22020	COG0151	Belongs to the GarS family
H4F89_RS22025	COG2204	response regulator
H4F89_RS22080	COG0352	thiamine-phosphate diphosphorylase activity
H4F89_RS22085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4F89_RS22090	COG2104	thiamine diphosphate biosynthetic process
H4F89_RS22135	COG0250	Participates in transcription elongation, termination and antitermination
H4F89_RS22245	COG0583	DNA-binding transcription factor activity
H4F89_RS22280	COG2207	Transcriptional regulator
H4F89_RS22290	COG0371	Dehydrogenase
H4F89_RS22315	COG0460	homoserine dehydrogenase
H4F89_RS22315	COG0527	aspartate kinase activity
H4F89_RS22320	COG0626	cystathionine gamma-synthase activity
H4F89_RS22330	COG2211	Major facilitator Superfamily
H4F89_RS22345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4F89_RS22350	COG1609	Transcriptional regulator
H4F89_RS22355	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4F89_RS22370	COG1575	Belongs to the MenA family. Type 1 subfamily
H4F89_RS22385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H4F89_RS22395	COG1494	fructose-1,6-bisphosphatase
H4F89_RS22405	COG3152	Membrane
H4F89_RS22420	COG0471	metal ion transport
H4F89_RS22450	COG3678	ATP-independent chaperone mediated protein folding
H4F89_RS22455	COG0745	RESPONSE REGULATOR receiver
H4F89_RS22460	COG2205	protein histidine kinase activity
H4F89_RS22465	COG2258	MOSC domain
H4F89_RS22470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4F89_RS22505	COG1454	alcohol dehydrogenase
H4F89_RS22520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4F89_RS22530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS22535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4F89_RS22535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4F89_RS22540	COG1363	Peptidase, m42
H4F89_RS22545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4F89_RS22545	COG3711	transcriptional antiterminator
H4F89_RS22565	COG0437	4 iron, 4 sulfur cluster binding
H4F89_RS22570	COG2864	formate dehydrogenase
H4F89_RS22585	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4F89_RS22595	COG4680	protein conserved in bacteria
H4F89_RS22600	COG5499	transcription regulator containing HTH domain
H4F89_RS22605	COG0456	acetyltransferase
H4F89_RS22620	COG1011	Hydrolase
H4F89_RS22625	COG1349	DNA-binding transcription factor activity
H4F89_RS22630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F89_RS22640	COG3684	Belongs to the aldolase LacD family
H4F89_RS22650	COG2017	converts alpha-aldose to the beta-anomer
H4F89_RS22660	COG1501	Belongs to the glycosyl hydrolase 31 family
H4F89_RS22730	COG0204	Acyl-transferase
H4F89_RS22745	COG3084	Protein conserved in bacteria
H4F89_RS22750	COG0746	molybdenum cofactor guanylyltransferase activity
H4F89_RS22755	COG1763	Mo-molybdopterin cofactor biosynthetic process
H4F89_RS22795	COG1739	Uncharacterized protein family UPF0029
H4F89_RS22820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H4F89_RS22835	COG0805	protein transport
H4F89_RS22900	COG0561	phosphatase activity
H4F89_RS22905	COG2267	carboxylic ester hydrolase activity
H4F89_RS22910	COG1280	lysine exporter protein (LysE YggA)
H4F89_RS22960	COG1011	Hydrolase
H4F89_RS23005	COG2959	enzyme of heme biosynthesis
H4F89_RS23010	COG3071	HemY protein
H4F89_RS23055	COG2244	polysaccharide biosynthetic process
H4F89_RS23060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4F89_RS23065	COG0456	acetyltransferase
H4F89_RS23070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H4F89_RS23075	COG1088	dTDP-glucose 4,6-dehydratase activity
H4F89_RS23080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H4F89_RS23095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4F89_RS23110	COG3118	belongs to the thioredoxin family
H4F89_RS23175	COG3978	acetolactate synthase activity
H4F89_RS23235	COG2186	Transcriptional regulator
H4F89_RS23240	COG0477	Major facilitator Superfamily
H4F89_RS23245	COG1609	Transcriptional regulator
H4F89_RS23250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F89_RS23260	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4F89_RS23290	COG2502	aspartate--ammonia ligase
H4F89_RS23295	COG1522	sequence-specific DNA binding
H4F89_RS23300	COG0716	FMN binding
H4F89_RS23315	COG3312	ion transport
H4F89_RS23370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4F89_RS23375	COG0573	inorganic phosphate transmembrane transporter activity
H4F89_RS23380	COG0581	inorganic phosphate transmembrane transporter activity
H4F89_RS23390	COG0704	Plays a role in the regulation of phosphate uptake
H4F89_RS23395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4F89_RS23400	COG2252	PERMEase
H4F89_RS23405	COG0431	NADPH-dependent FMN reductase
H4F89_RS23410	COG2091	lysine biosynthetic process via aminoadipic acid
H4F89_RS23515	COG1192	Involved in chromosome partitioning
H4F89_RS23605	COG0210	DNA helicase
H4F89_RS23745	COG4245	von Willebrand factor, type A
H4F89_RS23750	COG4245	von Willebrand factor, type A
H4F89_RS23780	COG1358	cellular component organization or biogenesis
H4F89_RS23895	COG3550	peptidyl-serine autophosphorylation
H4F89_RS23930	COG0789	Transcriptional regulator
H4F89_RS23980	COG0789	Transcriptional regulator
H4F89_RS24145	COG2890	protein-(glutamine-N5) methyltransferase activity
H4F89_RS24345	COG1983	PspC domain protein
H4F89_RS24355	COG1842	Phage shock protein A
H4F89_RS24360	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H4F89_RS24370	COG1028	Short-chain dehydrogenase reductase Sdr
H4F89_RS24375	COG1546	Belongs to the CinA family
H4F89_RS24390	COG3111	PFAM Bacterial OB fold (BOF) protein
H4F89_RS24530	COG2801	Transposase and inactivated derivatives
H4F89_RS24535	COG3547	Transposase (IS116 IS110 IS902 family)
H4F89_RS24545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H4F89_RS24550	COG3077	Addiction module antitoxin, RelB DinJ family
H4F89_RS24555	COG2026	Addiction module toxin, RelE StbE family
H4F89_RS24645	COG2801	Transposase and inactivated derivatives
H4F89_RS24675	COG1979	alcohol dehydrogenase
H4F89_RS24680	COG2814	Major facilitator Superfamily
H4F89_RS24690	COG2801	Transposase and inactivated derivatives
H4F89_RS24695	COG0431	NADPH-dependent FMN reductase
H4F89_RS24700	COG0640	Transcriptional regulator
H4F89_RS24705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H4F89_RS24710	COG1393	Belongs to the ArsC family
H4F89_RS24715	COG0589	response to stress
H4F89_RS24720	COG0659	secondary active sulfate transmembrane transporter activity
H4F89_RS24800	COG2205	protein histidine kinase activity
H4F89_RS24810	COG2194	sulfuric ester hydrolase activity
H4F89_RS24920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4F89_RS24945	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H4F89_RS24970	COG3039	Transposase