locus-tag class description E5N93_RS00005 ENOG4105CFH Aspartokinase E5N93_RS00015 ENOG4105D98 threonine synthase E5N93_RS00025 ENOG4105BZG amino acid carrier protein E5N93_RS00030 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E5N93_RS00035 ENOG4108RIR Molybdenum cofactor biosynthesis protein E5N93_RS00040 ENOG4106HK8 GPR1 FUN34 yaaH family protein E5N93_RS00045 ENOG4108QUJ UPF0174 protein YaaW E5N93_RS00050 ENOG4108WTA UPF0412 protein YaaI E5N93_RS00105 ENOG4108AF8 Chaperone E5N93_RS00110 ENOG4105CW0 outer membrane usher protein E5N93_RS00115 ENOG4105MHR Fimbrial protein E5N93_RS00130 ENOG4106PH7 chaperone E5N93_RS00150 ENOG4105DQS Transcriptional regulator E5N93_RS00165 ENOG4105CGH 5'-nucleotidase E5N93_RS00175 ENOG41061MV Arylsulfatase E5N93_RS00180 ENOG4105C4X radical SAM domain protein E5N93_RS00200 ENOG41063Z6 transcriptional regulator, lysR family E5N93_RS00220 ENOG410647N response to DNA damage stimulus E5N93_RS00225 ENOG4105DTN riboflavin biosynthesis protein ribF E5N93_RS00230 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) E5N93_RS00240 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E5N93_RS00260 ENOG4106YYS transcriptional regulatory protein E5N93_RS00265 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E5N93_RS00270 ENOG4105D9Q decarboxylase (Beta subunit) E5N93_RS00275 ENOG4107QSA Oxaloacetate decarboxylase E5N93_RS00280 ENOG4106AFN Lyase and sodium transporter (By similarity) E5N93_RS00285 ENOG4105D2K citrate carrier protein E5N93_RS00290 ENOG4105DUA (citrate (pro-3S)-lyase ligase E5N93_RS00300 ENOG4105CI0 Citrate lyase E5N93_RS00305 ENOG4105CHY citrate lyase, alpha E5N93_RS00320 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) E5N93_RS00330 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E5N93_RS00335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E5N93_RS00340 ENOG4108XNW Transcriptional activatory protein CaiF E5N93_RS00345 ENOG4108Z0R Transferase E5N93_RS00390 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5N93_RS00395 ENOG4105WQV ferredoxin-like protein E5N93_RS00400 ENOG4105C54 Major Facilitator superfamily E5N93_RS00405 ENOG4105M5B (LipO)protein E5N93_RS00425 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF E5N93_RS00430 ENOG4105CKD glutathione-regulated potassium-efflux system protein E5N93_RS00445 ENOG4105NWN ApaG protein E5N93_RS00455 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E5N93_RS00465 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E5N93_RS00475 ENOG4105D3G Pseudouridine synthase E5N93_RS00480 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E5N93_RS00485 ENOG4105CQ2 DNA polymerase E5N93_RS00505 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E5N93_RS00515 ENOG4105EF1 ribulokinase E5N93_RS00520 ENOG41063TF transcriptional regulator (AraC E5N93_RS00525 ENOG4108KF1 Membrane E5N93_RS00530 ENOG4107T0D ABC, transporter E5N93_RS00545 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) E5N93_RS00555 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5N93_RS00560 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5N93_RS00565 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E5N93_RS00580 ENOG41064T2 transcriptional regulator, lysR family E5N93_RS00585 ENOG4105C7K acetolactate synthase E5N93_RS00590 ENOG4108ZP8 Acetolactate synthase small subunit E5N93_RS00595 ENOG4107B7Y DNA-binding transcriptional regulator FruR E5N93_RS00610 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E5N93_RS00615 ENOG4105CJN penicillin-binding protein E5N93_RS00620 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E5N93_RS00625 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E5N93_RS00635 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) E5N93_RS00640 ENOG4105CNI cell division protein FtsW E5N93_RS00655 ENOG4105CPF Cell wall formation (By similarity) E5N93_RS00660 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E5N93_RS00665 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E5N93_RS00670 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E5N93_RS00680 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) E5N93_RS00690 ENOG4105M6F mutator MutT protein E5N93_RS00715 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E5N93_RS00725 ENOG4105D7Q type ii secretion system E5N93_RS00730 ENOG4107QHF type ii secretion system protein e E5N93_RS00735 ENOG4108ZUW Major pilin subunit E5N93_RS00745 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E5N93_RS00755 ENOG4106A72 regulatory protein AmpE E5N93_RS00760 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) E5N93_RS00765 ENOG4105CT4 transporter E5N93_RS00780 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E5N93_RS00785 ENOG4107QSN dihydrolipoamide acetyltransferase E5N93_RS00790 ENOG4107QN2 dihydrolipoyl dehydrogenase E5N93_RS00805 ENOG4108NST exported protein E5N93_RS00810 ENOG4107QIJ Aconitate hydratase 2 E5N93_RS00825 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E5N93_RS00830 ENOG4107S2N Type III effector Hrp-dependent E5N93_RS00835 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E5N93_RS00840 ENOG4105MVE transcriptional regulator E5N93_RS00855 ENOG4108ZRK uncharacterized protein yacC E5N93_RS00860 ENOG4105E3B Multicopper oxidase E5N93_RS00865 ENOG4105DZG Dehydrogenase E5N93_RS00870 ENOG4108UGV hypoxanthine phosphoribosyltransferase E5N93_RS00875 ENOG41077A9 carbonic anhydrase E5N93_RS00880 ENOG4105DA5 (ABC) transporter E5N93_RS00885 ENOG4105E3A (ABC) transporter E5N93_RS00890 ENOG4108MDY Fimbrial E5N93_RS00895 ENOG4105CW0 outer membrane usher protein E5N93_RS00900 ENOG4108UIF Chaperone E5N93_RS00910 ENOG4108YTN IIa component E5N93_RS00915 ENOG4107BJW polysaccharide deacetylase E5N93_RS00925 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) E5N93_RS00935 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E5N93_RS00940 ENOG4105DJ0 Poly(A) Polymerase E5N93_RS00945 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) E5N93_RS00950 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters E5N93_RS00960 ENOG4107XID 2'-5' rna ligase E5N93_RS00965 ENOG4105CQ7 ATP-dependent helicase E5N93_RS00970 ENOG4105BZ4 penicillin-binding protein E5N93_RS00975 ENOG4105E0K tonB-dependent siderophore receptor E5N93_RS00980 ENOG4105E0A ABC, transporter E5N93_RS00985 ENOG4105J76 Periplasmic binding protein E5N93_RS00990 ENOG4105S6R Iron-hydroxamate transporter permease subunit E5N93_RS01005 ENOG4106PG1 outer membrane usher protein E5N93_RS01010 ENOG4108FZ9 Chaperone E5N93_RS01015 ENOG4105NEV Fimbrial E5N93_RS01020 ENOG4105UGQ Fimbrial E5N93_RS01030 ENOG4106RDH Protein of unknown function (DUF2544) E5N93_RS01040 ENOG4105CMQ Chloride channel E5N93_RS01045 ENOG4108YX9 iron--sulfur cluster insertion protein erpA E5N93_RS01050 ENOG4105EN6 Membrane E5N93_RS01055 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E5N93_RS01065 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein E5N93_RS01070 ENOG4105C0H protease E5N93_RS01075 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR E5N93_RS01085 ENOG4105CSH Transporter E5N93_RS01090 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) E5N93_RS01100 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E5N93_RS01105 ENOG4105CE9 30S ribosomal protein S2 E5N93_RS01115 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) E5N93_RS01120 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) E5N93_RS01135 ENOG4105KNE Phosphatidate cytidylyltransferase E5N93_RS01145 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E5N93_RS01150 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) E5N93_RS01155 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E5N93_RS01160 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) E5N93_RS01170 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E5N93_RS01180 ENOG4105C0B DNA polymerase III (alpha subunit) E5N93_RS01190 ENOG4108M1A Chitin-binding protein E5N93_RS01195 ENOG4105CXN decarboxylase E5N93_RS01200 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase E5N93_RS01205 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E5N93_RS01210 ENOG4105M1T rho-binding antiterminator E5N93_RS01220 ENOG4108VWS Yaeq family E5N93_RS01225 ENOG4108YZN class I peptide chain release factor E5N93_RS01230 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion E5N93_RS01240 ENOG4108R96 Methyltransferase, YaeB family E5N93_RS01245 ENOG4108R8X outer membrane lipoprotein E5N93_RS01250 ENOG4105D01 (LipO)protein E5N93_RS01255 ENOG4108UMI ABC transporter, permease E5N93_RS01260 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E5N93_RS01265 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase E5N93_RS01300 ENOG4105CV8 reductase E5N93_RS01305 ENOG4105HEI LysR family (Transcriptional regulator E5N93_RS01310 ENOG4105F27 Major Facilitator E5N93_RS01320 ENOG4105F2W methyltransferase E5N93_RS01325 ENOG4105E9H Lytic Murein transglycosylase E5N93_RS01330 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E5N93_RS01335 ENOG4105D1A Methyltransferase E5N93_RS01340 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) E5N93_RS01345 ENOG4107RZZ dna polymerase iii epsilon subunit E5N93_RS01385 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5N93_RS01475 ENOG4105CS6 Rhs element vgr protein E5N93_RS01485 ENOG4107TV1 YD repeat protein E5N93_RS01495 ENOG4105CNA YD repeat protein E5N93_RS01515 ENOG4105CNA YD repeat protein E5N93_RS01565 ENOG4105W7K Transcriptional regulator E5N93_RS01575 ENOG4105T40 surface antigen msp4 family protein E5N93_RS01585 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E5N93_RS01590 ENOG4107QPN acyl-Coa dehydrogenase E5N93_RS01600 ENOG4105E7A Glutamine amidotransferase E5N93_RS01605 ENOG4105F7V ErfK ybiS ycfS ynhG family protein E5N93_RS01620 ENOG4108S2Y peptide Chain Release factor E5N93_RS01625 ENOG4105CIN aminoacyl-histidine dipeptidase E5N93_RS01630 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) E5N93_RS01645 ENOG4105FCK Membrane E5N93_RS01655 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) E5N93_RS01665 ENOG4108KU3 Integrase E5N93_RS01705 ENOG4105VIZ double-strand break repair protein E5N93_RS01770 ENOG4105CDU Replicative dna helicase E5N93_RS01790 ENOG4105NY2 NinB protein E5N93_RS01820 ENOG4105RWQ Protein of unknown function (DUF1364) E5N93_RS01865 ENOG4105KUS lysozyme E5N93_RS01870 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 E5N93_RS01980 ENOG4105CKK Glycosyl transferase, family 2 E5N93_RS01995 ENOG4105DFP Integrase E5N93_RS02130 ENOG4105V2F Uncharacterized protein yoac E5N93_RS02135 ENOG4105D94 Major Facilitator Superfamily E5N93_RS02140 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5N93_RS02145 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5N93_RS02150 ENOG4105ERH Fumarylacetoacetate hydrolase E5N93_RS02160 ENOG4105EJC lysr family transcriptional regulator E5N93_RS02185 ENOG4105CW0 outer membrane usher protein E5N93_RS02190 ENOG4108VEV chaperone E5N93_RS02195 ENOG4105X0I Fimbrial E5N93_RS02210 ENOG4107XTP (EAL) domain protein E5N93_RS02225 ENOG4108T1M outer membrane protein x E5N93_RS02245 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E5N93_RS02255 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5N93_RS02275 ENOG4105JHE Major Facilitator Superfamily E5N93_RS02280 ENOG4107QMH DNA methylase E5N93_RS02285 ENOG4105D8D Type III E5N93_RS02295 ENOG4105C4M (Ubiquinol oxidase) subunit I E5N93_RS02300 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5N93_RS02320 ENOG4105E82 cytochrome subunit of dehydrogenase E5N93_RS02325 ENOG4105TDT uncharacterized protein yahO E5N93_RS02330 ENOG4108JU7 Transcriptional regulator E5N93_RS02335 ENOG4105CR4 methylisocitrate lyase E5N93_RS02340 ENOG4105BZN citrate synthase E5N93_RS02345 ENOG4105DXD 2-methylcitrate dehydratase E5N93_RS02350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E5N93_RS02355 ENOG4105D52 delta-aminolevulinic acid dehydratase E5N93_RS02360 ENOG4108NSE outer membrane autotransporter barrel E5N93_RS02365 ENOG4108PNB DNA-binding transcriptional regulator E5N93_RS02370 ENOG4107R6D beta-lactam binding protein AmpH E5N93_RS02380 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 E5N93_RS02385 ENOG4107QS8 (LipO)protein E5N93_RS02390 ENOG4105FR5 inner membrane protein YaiY E5N93_RS02395 ENOG4105UNH Membrane E5N93_RS02400 ENOG4105CPF Cell wall formation (By similarity) E5N93_RS02420 ENOG4105VIF phosphate starvation-inducible protein E5N93_RS02425 ENOG4105BZU Histidine kinase E5N93_RS02430 ENOG4105II7 pyrroline-5-carboxylate reductase E5N93_RS02445 ENOG4105SS3 E5N93_RS02450 ENOG4105HBA AroM protein E5N93_RS02465 ENOG4105DKQ ROK family E5N93_RS02470 ENOG4105F27 Major Facilitator E5N93_RS02475 ENOG4105EYH Exonuclease E5N93_RS02480 ENOG4107RH8 nuclease SbcCD subunit D E5N93_RS02485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5N93_RS02490 ENOG4105BZU Histidine kinase E5N93_RS02495 ENOG4105CWM branched-chain amino acid transport system II carrier protein E5N93_RS02500 ENOG4105C85 amino acid E5N93_RS02505 ENOG4107R28 alpha amylase, catalytic region E5N93_RS02510 ENOG4105D3R alkyl hydroperoxide reductase E5N93_RS02530 ENOG4105VIE preprotein translocase, subunit YajC E5N93_RS02540 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E5N93_RS02555 ENOG4105N1F Hnh endonuclease E5N93_RS02575 ENOG4105DRB nucleoside-specific channel-forming protein E5N93_RS02580 ENOG4108KIC (LipO)protein E5N93_RS02590 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E5N93_RS02600 ENOG4107YIM Involved in the transcription termination process (By similarity) E5N93_RS02605 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E5N93_RS02610 ENOG4108ZAI phosphatidylglycerophosphatase a E5N93_RS02615 ENOG4105CPC Aldo Keto reductase E5N93_RS02625 ENOG4105CTB Polyprenyl synthetase E5N93_RS02630 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E5N93_RS02635 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) E5N93_RS02640 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component E5N93_RS02645 ENOG4108MP3 ABC transporter, permease E5N93_RS02650 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E5N93_RS02655 ENOG4105CY5 solute-binding protein E5N93_RS02660 ENOG4106S9K Transcriptional regulator E5N93_RS02665 ENOG4107STF Involved in phosphonate degradation (By similarity) E5N93_RS02670 ENOG4108KAZ Involved in phosphonate degradation (By similarity) E5N93_RS02675 ENOG4107S0N DJ-1 family E5N93_RS02680 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E5N93_RS02690 ENOG4107RDB Major Facilitator E5N93_RS02715 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E5N93_RS02720 ENOG4105CCU oxidase (Subunit III) E5N93_RS02725 ENOG4105BZ9 Cytochrome C oxidase, subunit I E5N93_RS02730 ENOG4105E2S oxidase) subunit II E5N93_RS02735 ENOG4105EYM Major Facilitator superfamily E5N93_RS02740 ENOG4105IEY (LipO)protein E5N93_RS02745 ENOG4105M85 Bola protein E5N93_RS02770 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) E5N93_RS02775 ENOG4105K70 DNA-binding protein E5N93_RS02780 ENOG4105EIN peptidylprolyl cis-trans isomerase E5N93_RS02785 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E5N93_RS02790 ENOG4108TGP Thioesterase superfamily protein E5N93_RS02800 ENOG4108NFA extracellular solute-binding protein E5N93_RS02825 ENOG4108XM1 transcriptional regulator AsnC family E5N93_RS02830 ENOG4105BZ1 (ABC) transporter E5N93_RS02835 ENOG4105BZ1 (ABC) transporter E5N93_RS02845 ENOG4108YZA Nitrogen regulatory protein pii E5N93_RS02850 ENOG4105BZU Histidine kinase E5N93_RS02855 ENOG4105C29 acyl-CoA thioesterase E5N93_RS02860 ENOG4108MNP Glycoprotein polysaccharide metabolism E5N93_RS02865 ENOG41080UX Methyltransferase E5N93_RS02875 ENOG41066DG (EAL) domain protein E5N93_RS02890 ENOG4105GSJ Inner membrane protein ylaC E5N93_RS02895 ENOG4108UW5 maltose o-acetyltransferase E5N93_RS02905 ENOG4108UKR Biofilm formation regulator YbaJ E5N93_RS02910 ENOG4105BZS acriflavin resistance protein E5N93_RS02915 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5N93_RS02920 ENOG4107XI7 Tetr family transcriptional regulator E5N93_RS02925 ENOG4105EGS Mechanosensitive ion channel E5N93_RS02930 ENOG4105DNE Transposase E5N93_RS02935 ENOG4106428 Protein of unknown function (DUF2496) E5N93_RS02940 ENOG4108URS primosomal replication protein n'' E5N93_RS02945 ENOG4105WD1 Membrane E5N93_RS02955 ENOG4107QMP dna polymerase iii subunits gamma and tau E5N93_RS02970 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) E5N93_RS02985 ENOG4105F2M alpha beta hydrolase fold-3 domain protein E5N93_RS02990 ENOG4107RE1 Inosine-guanosine kinase E5N93_RS02995 ENOG4105CKD glutathione-regulated potassium-efflux system protein E5N93_RS03000 ENOG4105EU0 Major facilitator Superfamily E5N93_RS03005 ENOG4105CGH 5'-nucleotidase E5N93_RS03010 ENOG4108Z66 YbaK ebsC protein E5N93_RS03015 ENOG4105MBR gumn family E5N93_RS03025 ENOG4105C59 p-type ATPase E5N93_RS03030 ENOG4108Z6Z Transcriptional regulator E5N93_RS03035 ENOG4105G5H Membrane E5N93_RS03040 ENOG4107QX8 SPFH domain, Band 7 family protein E5N93_RS03045 ENOG41083J0 (ABC) transporter E5N93_RS03050 ENOG4105C4B ABC transporter, permease E5N93_RS03055 ENOG4107QR8 Thioredoxin E5N93_RS03060 ENOG4105E1F short-chain dehydrogenase reductase E5N93_RS03065 ENOG4108UJV acyl-CoA thioesterase i E5N93_RS03070 ENOG4108I0Y (ABC) transporter E5N93_RS03075 ENOG4105CV6 ABC transporter, permease E5N93_RS03085 ENOG4105D01 (LipO)protein E5N93_RS03090 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E5N93_RS03095 ENOG4108UMI ABC transporter, permease E5N93_RS03100 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) E5N93_RS03110 ENOG4108Z2U ureidoglycolate hydrolase E5N93_RS03120 ENOG41060W2 glyoxylate carboligase E5N93_RS03125 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E5N93_RS03130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5N93_RS03140 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease E5N93_RS03150 ENOG4105DTE Xanthine uracil vitamin C permease E5N93_RS03155 ENOG4105BZW Glycerate kinase E5N93_RS03160 ENOG4105S0E allantoin catabolism protein E5N93_RS03165 ENOG4105CE7 Amidase, hydantoinase carbamoylase family E5N93_RS03170 ENOG4105DG4 malate L-lactate dehydrogenase E5N93_RS03175 ENOG4107R1Q Membrane protein FdrA E5N93_RS03180 ENOG4107REC cytoplasmic protein E5N93_RS03185 ENOG4105G5A Protein of unknown function (DUF2877) E5N93_RS03190 ENOG4105C5B carbamate kinase E5N93_RS03195 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E5N93_RS03200 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E5N93_RS03210 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E5N93_RS03230 ENOG4105S2T inner membrane protein YbcI E5N93_RS03235 ENOG4105WQ3 Rna-binding protein E5N93_RS03250 ENOG4108WDE Fimbrial protein E5N93_RS03255 ENOG4105NJT Fimbrial protein E5N93_RS03260 ENOG4108AF8 Chaperone E5N93_RS03265 ENOG4105CW0 outer membrane usher protein E5N93_RS03270 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) E5N93_RS03275 ENOG4108ZI2 Fimbrial protein E5N93_RS03280 ENOG4108Q9V regulatoR E5N93_RS03285 ENOG4106721 fimbriae Y protein E5N93_RS03295 ENOG4106KCD HTH_LUXR E5N93_RS03305 ENOG4108KU3 Integrase E5N93_RS03320 ENOG4105CKK Glycosyl transferase, family 2 E5N93_RS03325 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) E5N93_RS03335 ENOG4105GR3 Histidine kinase E5N93_RS03340 ENOG4108IJF Heavy metal efflux pump, CzcA E5N93_RS03345 ENOG4108K01 transcriptional regulator E5N93_RS03350 ENOG4107QN2 dihydrolipoyl dehydrogenase E5N93_RS03355 ENOG41066GK UPF0379 protein ykgI E5N93_RS03360 ENOG4108KBJ Inner membrane protein YkgB E5N93_RS03370 ENOG4105C85 amino acid E5N93_RS03375 ENOG4105CUY Mechanosensitive ion channel E5N93_RS03385 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5N93_RS03390 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E5N93_RS03400 ENOG4105F3R pts system mannose fructose sorbose family iid E5N93_RS03420 ENOG4108RCM Nitroreductase E5N93_RS03425 ENOG4105MSB protein, conserved in bacteria E5N93_RS03430 ENOG41067SE Tetr family transcriptional regulator E5N93_RS03435 ENOG4105HFT AraC family transcriptional regulator E5N93_RS03440 ENOG4105WQ6 Membrane E5N93_RS03445 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) E5N93_RS03450 ENOG4108TSE Transferase E5N93_RS03455 ENOG4107RNH Outer membrane receptor FepA E5N93_RS03460 ENOG4105E93 esterase E5N93_RS03465 ENOG41085A6 mbth domain-containing protein E5N93_RS03470 ENOG4105C0W non-ribosomal peptide synthetase E5N93_RS03475 ENOG4108QY5 Ferric enterobactin transport protein E5N93_RS03480 ENOG4105E0A ABC, transporter E5N93_RS03485 ENOG4105TVJ transport system, permease E5N93_RS03490 ENOG4105DQ5 transport system permease protein E5N93_RS03495 ENOG4105E8G Major facilitator Superfamily E5N93_RS03500 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein E5N93_RS03505 ENOG4105E4F Isochorismate synthase E5N93_RS03510 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E5N93_RS03515 ENOG4105WQI isochorismatase E5N93_RS03520 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E5N93_RS03525 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) E5N93_RS03530 ENOG4105D22 carbon starvation protein E5N93_RS03535 ENOG4105VCD cytoplasmic protein E5N93_RS03540 ENOG4107SCQ Iron-containing alcohol dehydrogenase E5N93_RS03545 ENOG4105CHM Aminotransferase E5N93_RS03550 ENOG4105GTN ParB Domain Protein Nuclease E5N93_RS03555 ENOG4105BZV Phosphoadenosine phosphosulfate reductase E5N93_RS03560 ENOG4105DQS Transcriptional regulator E5N93_RS03565 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase E5N93_RS03570 ENOG4105D3R alkyl hydroperoxide reductase E5N93_RS03575 ENOG4108JU3 Alkyl hydroperoxide reductase E5N93_RS03585 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E5N93_RS03590 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N93_RS03600 ENOG4108U51 Universal stress protein E5N93_RS03605 ENOG4105E2A Dehydrogenase E5N93_RS03610 ENOG4105NXH GreA GreB family elongation factor E5N93_RS03615 ENOG4105KTS ribonuclease E5N93_RS03620 ENOG4107QPK )-transporter E5N93_RS03625 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E5N93_RS03630 ENOG4105YGP holo-ACP synthase CitX E5N93_RS03635 ENOG4105CHY citrate lyase, alpha E5N93_RS03640 ENOG4105CI0 Citrate lyase E5N93_RS03645 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) E5N93_RS03650 ENOG4105DUA (citrate (pro-3S)-lyase ligase E5N93_RS03655 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E5N93_RS03660 ENOG4106YYS transcriptional regulatory protein E5N93_RS03665 ENOG4105CEE C4-dicarboxylate transporter E5N93_RS03670 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) E5N93_RS03680 ENOG4107Z6W Protein CrcB homolog E5N93_RS03700 ENOG41064T2 transcriptional regulator, lysR family E5N93_RS03710 ENOG4108Z43 UPF0250 protein E5N93_RS03715 ENOG4105DZ1 carboxypeptidase E5N93_RS03720 ENOG4105K6T rare lipoprotein A E5N93_RS03725 ENOG4105CNI cell division protein FtsW E5N93_RS03730 ENOG4105CJN penicillin-binding protein E5N93_RS03735 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) E5N93_RS03740 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E5N93_RS03745 ENOG4108TGR phosphatase E5N93_RS03750 ENOG4107QZB decarboxylase E5N93_RS03755 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) E5N93_RS03760 ENOG4105DJF DNA polymerase III, delta' subunit E5N93_RS03765 ENOG4108U2H Rare lipoprotein B E5N93_RS03785 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E5N93_RS03790 ENOG4108JUB Transcriptional regulator E5N93_RS03795 ENOG4107PAI alpha helical protein E5N93_RS03805 ENOG41069CF Protein of unknown function (DUF1266) E5N93_RS03810 ENOG4105QFC Hsc56 co-chaperone of HscC E5N93_RS03815 ENOG41069CF Protein of unknown function (DUF1266) E5N93_RS03820 ENOG4105QFC Hsc56 co-chaperone of HscC E5N93_RS03825 ENOG4105F7F Chaperone E5N93_RS03835 ENOG4105DU0 nucleoside hydrolase E5N93_RS03840 ENOG4105CDA abc transporter atp-binding protein E5N93_RS03845 ENOG4105DRP amino acid AbC transporter E5N93_RS03850 ENOG4105EAD ABC transporter E5N93_RS03855 ENOG4107RP9 extracellular solute-binding protein, family 3 E5N93_RS03860 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E5N93_RS03865 ENOG4108JU5 Magnesium and cobalt efflux protein E5N93_RS03870 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) E5N93_RS03875 ENOG4105C9A Phoh family E5N93_RS03885 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E5N93_RS03930 ENOG4105CAQ asparagine synthetase E5N93_RS03935 ENOG4105D4U had-superfamily hydrolase, subfamily iia E5N93_RS03940 ENOG4105E2R ROK family E5N93_RS03945 ENOG4105CE4 GlcNAc 6-P deacetylase E5N93_RS03955 ENOG4105CI1 PTS System E5N93_RS03965 ENOG4105J5J Outer membrane porin E5N93_RS03970 ENOG4105GX6 (LipO)protein E5N93_RS03975 ENOG4105CSH Transporter E5N93_RS03980 ENOG41079YP Citrate utilization protein b E5N93_RS03985 ENOG4107EFR Flavocytochrome c E5N93_RS03990 ENOG4106P55 Transcriptional regulator E5N93_RS03995 ENOG41090R7 Ferric uptake E5N93_RS04000 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) E5N93_RS04005 ENOG4105NNH LexA regulated protein E5N93_RS04010 ENOG4105EV9 Alpha Beta Hydrolase E5N93_RS04015 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) E5N93_RS04020 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 E5N93_RS04030 ENOG4105D5Q Arginine ornithine antiporter E5N93_RS04035 ENOG4105CXN decarboxylase E5N93_RS04045 ENOG4105EEX Two component transcriptional regulator (Winged helix family E5N93_RS04050 ENOG4105C08 Histidine kinase E5N93_RS04060 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E5N93_RS04075 ENOG4105XIQ Protein of unknown function (DUF2517) E5N93_RS04080 ENOG4105CVP deoxyribo-dipyrimidine photolyase E5N93_RS04090 ENOG4107QNR UPF0135 protein E5N93_RS04095 ENOG4105P4J Allophanate hydrolase, subunit 1 E5N93_RS04100 ENOG4107R7A Allophanate hydrolase subunit 2 E5N93_RS04105 ENOG4105E7W lamb ycsf family protein E5N93_RS04115 ENOG4108W9T type 1 fimbriae regulatory protein E5N93_RS04155 ENOG410602S Transferase E5N93_RS04180 ENOG4108KK1 membrane protein AbrB duplication E5N93_RS04185 ENOG4105BZN citrate synthase E5N93_RS04190 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E5N93_RS04195 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E5N93_RS04200 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E5N93_RS04205 ENOG4105E33 succinate dehydrogenase E5N93_RS04210 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E5N93_RS04215 ENOG4105C7S Dehydrogenase E5N93_RS04225 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E5N93_RS04230 ENOG4105C4M (Ubiquinol oxidase) subunit I E5N93_RS04235 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5N93_RS04245 ENOG4105KJB cyd operon protein YbgE E5N93_RS04250 ENOG4107YD3 Thioesterase E5N93_RS04255 ENOG4105E02 MotA TolQ exbB proton channel E5N93_RS04265 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA E5N93_RS04275 ENOG4105KCK Peptidoglycan-associated lipoprotein E5N93_RS04280 ENOG4105UFD tol-pal system protein YbgF E5N93_RS04325 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E5N93_RS04330 ENOG4105PGM cation diffusion facilitator family transporter E5N93_RS04335 ENOG4105JND homeobox protein E5N93_RS04340 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5N93_RS04345 ENOG4107GFK fumarate E5N93_RS04350 ENOG4106DSS Tartrate dehydratase subunit alpha E5N93_RS04355 ENOG4105C5Q Transcriptional regulator E5N93_RS04365 ENOG4107QWE )-transporter E5N93_RS04370 ENOG4106AFN Lyase and sodium transporter (By similarity) E5N93_RS04375 ENOG4107QSA Oxaloacetate decarboxylase E5N93_RS04385 ENOG4105D9Q decarboxylase (Beta subunit) E5N93_RS04390 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E5N93_RS04395 ENOG4105EHG Permease protein E5N93_RS04400 ENOG4105E0A ABC, transporter E5N93_RS04410 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E5N93_RS04420 ENOG4105F0Z galactose-1-phosphate uridylyltransferase E5N93_RS04425 ENOG4105CMR udp-glucose 4-epimerase E5N93_RS04435 ENOG4105DKW ABC transporter E5N93_RS04440 ENOG4105F4R Transcriptional regulator mode E5N93_RS04450 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E5N93_RS04455 ENOG4105E0C molybdate abc transporter E5N93_RS04465 ENOG4108K4B hydrolase E5N93_RS04475 ENOG4105NBR Pectinesterase E5N93_RS04480 ENOG4105CI2 imidazolone-5-propionate hydrolase E5N93_RS04500 ENOG4105C84 Histidine ammonia-lyase E5N93_RS04505 ENOG4108V1U phospholipid-binding protein E5N93_RS04510 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E5N93_RS04520 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E5N93_RS04525 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E5N93_RS04530 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E5N93_RS04555 ENOG4105CHW UPF0052 protein E5N93_RS04565 ENOG4108RIR Molybdenum cofactor biosynthesis protein E5N93_RS04575 ENOG4105M00 molybdopterin converting factor, subunit 1 E5N93_RS04580 ENOG4108ZAF Molybdopterin E5N93_RS04585 ENOG4105HFZ Membrane E5N93_RS04590 ENOG4108RS6 transposase E5N93_RS04595 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5N93_RS04600 ENOG4108M9K flagella biosynthesis protein FliZ E5N93_RS04605 ENOG4105EAB amino acid AbC transporter E5N93_RS04610 ENOG4105K6H D-cysteine desulfhydrase E5N93_RS04615 ENOG4105E5Q amino acid AbC transporter E5N93_RS04620 ENOG4105CDA abc transporter atp-binding protein E5N93_RS04625 ENOG4105VJY transcriptional regulator E5N93_RS04630 ENOG4105XVG cytoplasmic protein E5N93_RS04640 ENOG4105WH1 Two component transcriptional regulator luxr family E5N93_RS04685 ENOG4106RHG Yeca family E5N93_RS04690 ENOG4105E0U tyrosine-specific transport protein E5N93_RS04695 ENOG4105VVZ metal-binding protein E5N93_RS04700 ENOG41090A1 ferritin E5N93_RS04705 ENOG4105P23 (LipO)protein E5N93_RS04715 ENOG4108UEC Ferritin-like protein E5N93_RS04730 ENOG4108K4C ec 3.1.3.12 E5N93_RS04740 ENOG4108VA4 Universal stress protein E5N93_RS04750 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) E5N93_RS04755 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region E5N93_RS04760 ENOG4107RD7 Flagellar Motor Protein, MotA E5N93_RS04765 ENOG4105ER2 Ompa motb domain protein E5N93_RS04770 ENOG4105CBS Chea signal transduction histidine kinase E5N93_RS04775 ENOG4108V3W Chemotaxis protein, CheW E5N93_RS04780 ENOG4105C8Q Methyl-accepting chemotaxis E5N93_RS04785 ENOG4105BZU Histidine kinase E5N93_RS04790 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) E5N93_RS04795 ENOG4108VYJ response regulator receiver protein E5N93_RS04800 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) E5N93_RS04805 ENOG4105D00 flagellar biosynthetic protein flhB E5N93_RS04810 ENOG4105D7B Flagellar biosynthesis protein flha E5N93_RS04815 ENOG4105IRD Flagellar protein FlhE E5N93_RS04820 ENOG4105F5H Glycosyl Hydrolase Family 88 E5N93_RS04835 ENOG4106ZCM YecM protein E5N93_RS04845 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) E5N93_RS04855 ENOG4105WJG Glutathione E5N93_RS04860 ENOG41081XQ Conserved Protein E5N93_RS04865 ENOG4105D3W isochorismatase E5N93_RS04870 ENOG4105C9M aspartyl-trna synthetase E5N93_RS04875 ENOG4108TIT dATP pyrophosphohydrolase E5N93_RS04880 ENOG4105CDY transcriptional regulatory protein E5N93_RS04890 ENOG4107S01 Repressor protein MetJ E5N93_RS04910 ENOG4105FAV ABC, transporter E5N93_RS04915 ENOG4105FDK ABC transporter E5N93_RS04920 ENOG4105NXV High-affinity zinc uptake system protein E5N93_RS04925 ENOG4105DR5 peptidase E5N93_RS04930 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E5N93_RS04935 ENOG4105CA9 Pyruvate kinase E5N93_RS04940 ENOG4106KNT transcriptional regulator E5N93_RS04945 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E5N93_RS04950 ENOG4105C01 Dihydroxy-acid dehydratase E5N93_RS04955 ENOG4108UHU Aldolase E5N93_RS04960 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR E5N93_RS04965 ENOG4105X2V dna damage-inducible protein E5N93_RS04970 ENOG4105RSZ secreted protein E5N93_RS04975 ENOG4108Q2J Inner membrane protein YebE E5N93_RS04980 ENOG4105CUG Oligopeptidase b E5N93_RS04985 ENOG4105UMD exodeoxyribonuclease X E5N93_RS04990 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E5N93_RS04995 ENOG4105MPK DNA polymerase III subunit theta E5N93_RS05000 ENOG4105FXM Copper resistance protein E5N93_RS05005 ENOG4108PNC copper resistance E5N93_RS05010 ENOG4105NKT exported protein E5N93_RS05020 ENOG41076J9 exonuclease VIII E5N93_RS05030 ENOG4108YV9 Protein of unknown function (DUF2514) E5N93_RS05050 ENOG4105UZW Tail fiber assembly protein E5N93_RS05090 ENOG4105DWP Membrane E5N93_RS05125 ENOG4105VEV -acetyltransferase E5N93_RS05135 ENOG41064WM Uncharacterized protein YcgX E5N93_RS05140 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling E5N93_RS05150 ENOG4108R1E Serine threonine protein phosphatase 1 E5N93_RS05155 ENOG4105UVW uncharacterized protein yebW E5N93_RS05160 ENOG4105WT8 Protein of unknown function (DUF1480) E5N93_RS05165 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E5N93_RS05170 ENOG4105DY2 Paraquat-inducible protein b E5N93_RS05175 ENOG4105H2K paraquat-inducible protein a E5N93_RS05180 ENOG4108ZGC gaf domain protein E5N93_RS05190 ENOG4105CN1 protease E5N93_RS05195 ENOG4105D0M Protease HtpX homolog E5N93_RS05200 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N93_RS05205 ENOG4105J4Q Transcriptional regulator E5N93_RS05215 ENOG4106CCY Protein MgrB homolog E5N93_RS05220 ENOG4105Q3Y exported protein E5N93_RS05235 ENOG4105CJN penicillin-binding protein E5N93_RS05240 ENOG4105DHI Methyltransferase E5N93_RS05255 ENOG4105F3R pts system mannose fructose sorbose family iid E5N93_RS05260 ENOG4105ETZ PTS System E5N93_RS05265 ENOG4105DAS pts system E5N93_RS05270 ENOG4105EE5 Membrane protein terC E5N93_RS05275 ENOG4107XTP (EAL) domain protein E5N93_RS05280 ENOG4105EJQ L-serine dehydratase E5N93_RS05290 ENOG4105CRQ synthase (Component I) E5N93_RS05295 ENOG4105X5C UPF0181 protein E5N93_RS05300 ENOG4105M4H endoribonuclease L-psp E5N93_RS05305 ENOG4105DVT helicase E5N93_RS05310 ENOG41072GX Peptidase M22 Glycoprotease E5N93_RS05315 ENOG4105Y4Z Outer Membrane Lipoprotein E5N93_RS05320 ENOG4105CEY Amp-dependent synthetase and ligase E5N93_RS05325 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) E5N93_RS05335 ENOG4107QMS site-determining protein E5N93_RS05350 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E5N93_RS05365 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation E5N93_RS05375 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) E5N93_RS05390 ENOG4105ED1 spovr family E5N93_RS05400 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E5N93_RS05410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A E5N93_RS05420 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) E5N93_RS05435 ENOG4105D82 Glutamate dehydrogenase E5N93_RS05445 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5N93_RS05450 ENOG4105C4M (Ubiquinol oxidase) subunit I E5N93_RS05455 ENOG4105MVP hydrogenase-1 operon protein HyaF E5N93_RS05460 ENOG4108VXY Hydrogenase-1 operon protein HyaE E5N93_RS05465 ENOG4108USZ hydrogenase E5N93_RS05470 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E5N93_RS05480 ENOG4105E3S small subunit E5N93_RS05490 ENOG4105C3G gtp-binding protein E5N93_RS05500 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria E5N93_RS05505 ENOG4105CHH sulfate transporter E5N93_RS05510 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E5N93_RS05515 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) E5N93_RS05525 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) E5N93_RS05535 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E5N93_RS05540 ENOG4108YY7 Invasion gene expression up-regulator SirB E5N93_RS05545 ENOG41063JG Transcriptional regulator E5N93_RS05555 ENOG4105EWV Sodium calcium exchanger membrane region E5N93_RS05560 ENOG4105WS7 Cation transport regulator E5N93_RS05565 ENOG41090EX DsrE family E5N93_RS05570 ENOG4105ID0 Putative invasin E5N93_RS05575 ENOG4105WH1 Two component transcriptional regulator luxr family E5N93_RS05580 ENOG4105BZU Histidine kinase E5N93_RS05585 ENOG4105DQQ Major facilitator superfamily MFS_1 E5N93_RS05590 ENOG4105CRU nitrate reductase, alpha subunit E5N93_RS05595 ENOG4108IUE nitrate reductase beta subunit E5N93_RS05600 ENOG4105R3A Nitrate reductase E5N93_RS05605 ENOG41076YT nitrate reductase, gamma subunit E5N93_RS05650 ENOG4105CIY formyltetrahydrofolate deformylase E5N93_RS05655 ENOG4105K5B UPF0225 protein E5N93_RS05660 ENOG4105D78 K07001 NTE family protein E5N93_RS05665 ENOG4105I93 response regulator E5N93_RS05670 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E5N93_RS05685 ENOG4105C0A alcohol dehydrogenase E5N93_RS05690 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein E5N93_RS05695 ENOG4107QSI ABC, transporter E5N93_RS05700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E5N93_RS05705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E5N93_RS05710 ENOG4105C3U ABC transporter E5N93_RS05715 ENOG4108JQ7 (ABC) transporter E5N93_RS05720 ENOG4105EYW Ion transport protein E5N93_RS05740 ENOG4105K9H YciI-like protein E5N93_RS05745 ENOG410822N TonB family E5N93_RS05750 ENOG4105NAU thioesterase Superfamily protein E5N93_RS05765 ENOG4105PI0 Ferredoxin E5N93_RS05770 ENOG4105EIF outer membrane protein W E5N93_RS05775 ENOG4105WEF catalase E5N93_RS05780 ENOG4108N8X transition metal ion binding E5N93_RS05785 ENOG4108Z9Z response to DNA damage stimulus E5N93_RS05795 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) E5N93_RS05805 ENOG4105DK0 Indole-3-glycerol phosphate synthase E5N93_RS05810 ENOG4108EFP Anthranilate synthase component II E5N93_RS05815 ENOG4105CRQ synthase (Component I) E5N93_RS05825 ENOG4105DB7 PHP domain protein E5N93_RS05830 ENOG4107RTD sua5 ycio yrdc ywlc family protein E5N93_RS05835 ENOG4105FE9 pseudouridine synthase E5N93_RS05840 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase E5N93_RS05845 ENOG4105UBK short-chain dehydrogenase reductase E5N93_RS05850 ENOG4105ERU peptidase E5N93_RS05855 ENOG4105RKX Protein of unknown function (DUF2498) E5N93_RS05860 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E5N93_RS05865 ENOG4107R11 Transcriptional regulator E5N93_RS05880 ENOG4107QM5 aconitate hydratase E5N93_RS05885 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) E5N93_RS05890 ENOG4105EYK Phosphatidylglycerophosphatase B E5N93_RS05895 ENOG4105Q4A inner membrane protein yciS E5N93_RS05900 ENOG4105CFV Tetratricopeptide repeat protein E5N93_RS05905 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) E5N93_RS05910 ENOG4108ZJT translation initiation factor, Sui1 E5N93_RS05915 ENOG41061RM osmotically inducible lipoprotein E5N93_RS05920 ENOG4105N2W Transcriptional regulator E5N93_RS05930 ENOG4105BZU Histidine kinase E5N93_RS05940 ENOG4105Q4T oxidoreductase E5N93_RS05945 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E5N93_RS05970 ENOG4108JQ2 peptide transport system atp-binding protein E5N93_RS05975 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein E5N93_RS05980 ENOG4108EU3 peptide transport system, permease E5N93_RS05985 ENOG4108EKA peptide transport system, permease E5N93_RS05990 ENOG4108J59 Extracellular solute-binding protein, family 5 E5N93_RS05995 ENOG4105E51 psp operon transcriptional activator E5N93_RS06000 ENOG41087YS Phage shock protein A E5N93_RS06005 ENOG4105YYT phage shock protein B E5N93_RS06010 ENOG4105FM1 phage shock protein C E5N93_RS06015 ENOG4105NNG Peripheral inner membrane phage-shock protein E5N93_RS06020 ENOG4105K8Z Phage shock protein E5N93_RS06025 ENOG4105CM6 amino acid regulated cytosolic protein E5N93_RS06030 ENOG4106K28 UPF0283 membrane protein E5N93_RS06035 ENOG4108JU8 Transcriptional regulator E5N93_RS06040 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E5N93_RS06045 ENOG4107S8C mandelate racemase muconate lactonizing E5N93_RS06050 ENOG4105KXI murein peptide amidase A E5N93_RS06055 ENOG4107QSI ABC, transporter E5N93_RS06065 ENOG4105HEI LysR family (Transcriptional regulator E5N93_RS06070 ENOG4105CV8 reductase E5N93_RS06075 ENOG4105F6U Short-chain dehydrogenase reductase Sdr E5N93_RS06080 ENOG4108XFH Transcriptional regulator E5N93_RS06095 ENOG4106PHM regulatory protein E5N93_RS06115 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E5N93_RS06135 ENOG4105D64 Mechanosensitive ion channel E5N93_RS06140 ENOG4105S5I Membrane E5N93_RS06145 ENOG4105Q9Y Universal stress protein E5N93_RS06150 ENOG4105DS0 Transcriptional regulator, Crp Fnr family E5N93_RS06155 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E5N93_RS06160 ENOG4108DG9 Smr protein MutS2 E5N93_RS06165 ENOG4105C8Q Methyl-accepting chemotaxis E5N93_RS06180 ENOG4105C1J atp-dependent rna helicase E5N93_RS06200 ENOG410814C multidrug resistance protein E5N93_RS06205 ENOG4108RW8 Universal stress protein F E5N93_RS06210 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) E5N93_RS06220 ENOG4105IKK cytoplasmic protein E5N93_RS06225 ENOG41090X5 Heat shock protein hslJ E5N93_RS06230 ENOG4105C5I Dehydrogenase E5N93_RS06235 ENOG4107H52 Dicarboxylate transport E5N93_RS06240 ENOG410689M (LipO)protein E5N93_RS06245 ENOG4105WXT Conserved Protein E5N93_RS06260 ENOG4105CQ7 ATP-dependent helicase E5N93_RS06265 ENOG4107DB1 DUF218 domain E5N93_RS06270 ENOG4105CPW cytochrome b561 E5N93_RS06275 ENOG4108WF3 methyltransferase E5N93_RS06285 ENOG4105E5Q amino acid AbC transporter E5N93_RS06295 ENOG4105E5Q amino acid AbC transporter E5N93_RS06300 ENOG4107R0W ABC transporter E5N93_RS06310 ENOG4107ZUJ lipid metabolic process E5N93_RS06335 ENOG4105C8Q Methyl-accepting chemotaxis E5N93_RS06340 ENOG4105DDW LysR family Transcriptional regulator E5N93_RS06345 ENOG4105E32 cytoplasmic protein E5N93_RS06350 ENOG4105EBR Carboxylesterase E5N93_RS06355 ENOG4105DJ9 glucan biosynthesis protein E5N93_RS06360 ENOG4108YYC ycei family E5N93_RS06370 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) E5N93_RS06375 ENOG4108PQ7 sgc region transcriptional regulator E5N93_RS06380 ENOG4108RK0 3-epimerase E5N93_RS06385 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E5N93_RS06390 ENOG4106P19 photosystem i assembly btpa E5N93_RS06395 ENOG4105DT3 PTS system, galactitol-specific IIc component E5N93_RS06400 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E5N93_RS06405 ENOG4105CN9 Peptidase m42 family protein E5N93_RS06410 ENOG4108Z9I -acetyltransferase E5N93_RS06415 ENOG4107WE3 acetyltransferase YdcK E5N93_RS06420 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein E5N93_RS06425 ENOG41088CC tellurite resistance protein tehB E5N93_RS06430 ENOG4108KKZ (LipO)protein E5N93_RS06435 ENOG4105DKK Benzoate E5N93_RS06440 ENOG4108JCI Transcriptional regulator E5N93_RS06445 ENOG4105CFP Peptidase U32 E5N93_RS06450 ENOG4105RR0 Protein of unknown function (DUF2554) E5N93_RS06470 ENOG4108UQS dipeptidase E5N93_RS06475 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E5N93_RS06480 ENOG4105C26 Dehydrogenase E5N93_RS06490 ENOG410654E Membrane E5N93_RS06510 ENOG4105R71 cytoplasmic protein E5N93_RS06515 ENOG4108T9Y Inner membrane protein ydcZ E5N93_RS06520 ENOG4108Z7F N-acetyltransferase E5N93_RS06525 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E5N93_RS06530 ENOG4108WYP Transcriptional regulator E5N93_RS06535 ENOG4105CHB tonB-dependent Receptor E5N93_RS06540 ENOG4108NS2 receptor E5N93_RS06545 ENOG4105SUV lipoprotein YgdR E5N93_RS06550 ENOG4105C85 amino acid E5N93_RS06565 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase E5N93_RS06570 ENOG4105JAB phenazine biosynthesis protein, phzf family E5N93_RS06575 ENOG4105D0D Nitrate reductase 2, gamma subunit E5N93_RS06580 ENOG4108NZN Respiratory nitrate reductase 2 delta chain E5N93_RS06585 ENOG4108IUE nitrate reductase beta subunit E5N93_RS06590 ENOG4105CRU nitrate reductase, alpha subunit E5N93_RS06595 ENOG4107QND Nitrite extrusion protein E5N93_RS06630 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N93_RS06635 ENOG4108MG3 formate dehydrogenase E5N93_RS06640 ENOG4105DQ4 alcohol dehydrogenase E5N93_RS06655 ENOG4105TPS biofilm-dependent modulation protein E5N93_RS06660 ENOG4108Z9K Osmotically inducible protein E5N93_RS06665 ENOG4105XXV Acid-resistance protein E5N93_RS06675 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E5N93_RS06690 ENOG4105C87 Aminotransferase class I and II E5N93_RS06695 ENOG4105DFD Na H antiporter E5N93_RS06700 ENOG41060NJ transcriptional regulator E5N93_RS06750 ENOG4108UQ8 endoribonuclease L-psp E5N93_RS06755 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) E5N93_RS06780 ENOG4108I5G Major Facilitator superfamily E5N93_RS06785 ENOG4105CPQ Dehydrogenase E5N93_RS06790 ENOG4105C6F GntR Family Transcriptional Regulator E5N93_RS06805 ENOG4105DPX Hydrogenase, large subunit E5N93_RS06810 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E5N93_RS06830 ENOG4105MVP hydrogenase-1 operon protein HyaF E5N93_RS06855 ENOG4105FFC UPF0187 protein E5N93_RS06860 ENOG4105M0C cytoplasmic protein E5N93_RS06870 ENOG4105C26 Dehydrogenase E5N93_RS06875 ENOG4105EGI Transcriptional regulator E5N93_RS06885 ENOG4105F27 Major Facilitator E5N93_RS06895 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes E5N93_RS06900 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF E5N93_RS06905 ENOG4106DNR multiple antibiotic resistance protein E5N93_RS06910 ENOG4108594 Permease of the drug metabolite transporter E5N93_RS06915 ENOG4105E5W Transporter E5N93_RS06925 ENOG4108YDI single-species biofilm formation on inanimate substrate E5N93_RS06930 ENOG4108WTK competence damage-inducible protein E5N93_RS06945 ENOG4105DGW oligopeptidase A E5N93_RS06950 ENOG4105EMU Dehydrogenase E5N93_RS06955 ENOG4107XBN GntR Family Transcriptional Regulator E5N93_RS06960 ENOG41061EV selenium-binding protein YdfZ E5N93_RS06965 ENOG4105DEI Mannitol dehydrogenase E5N93_RS06980 ENOG4105CPQ Dehydrogenase E5N93_RS07000 ENOG4108MK9 spermidine N(1)-acetyltransferase E5N93_RS07010 ENOG4105KBG Protein of unknown function (DUF1161) E5N93_RS07020 ENOG4105C3J Cysteine desulfurase E5N93_RS07025 ENOG4105QAX Iron-sulfur E5N93_RS07030 ENOG4107KGK dmso reductase anchor subunit E5N93_RS07035 ENOG4108NEM leader-binding protein dmsD E5N93_RS07040 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component E5N93_RS07045 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E5N93_RS07050 ENOG4105E90 ABC transporter E5N93_RS07055 ENOG4108IJ8 ABC transporter E5N93_RS07060 ENOG4105CMQ Chloride channel E5N93_RS07065 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E5N93_RS07070 ENOG4105DAG ROK family E5N93_RS07075 ENOG4106NZI LysR family Transcriptional regulator E5N93_RS07080 ENOG4105D94 Major Facilitator Superfamily E5N93_RS07090 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap E5N93_RS07110 ENOG4105DSF transport protein E5N93_RS07115 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E5N93_RS07120 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E5N93_RS07125 ENOG4105C5D exported protein E5N93_RS07130 ENOG4105D5Q Arginine ornithine antiporter E5N93_RS07135 ENOG4105RA2 Membrane E5N93_RS07140 ENOG4107EXC regulatoR E5N93_RS07150 ENOG4105FCK Membrane E5N93_RS07155 ENOG4105CPN adenine deaminase E5N93_RS07160 ENOG4105JJR Histidine kinase E5N93_RS07170 ENOG4105C9Q fumarate hydratase class II E5N93_RS07175 ENOG4107GFK fumarate E5N93_RS07180 ENOG4105EIP mannose-6-phosphate isomerase E5N93_RS07185 ENOG4106J39 exported protein E5N93_RS07190 ENOG4105CI1 PTS System E5N93_RS07200 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E5N93_RS07205 ENOG4105D9R oxidoreductase E5N93_RS07210 ENOG4106C6R beta-lactam resistance protein E5N93_RS07220 ENOG4105M9B inner membrane protein ydgK E5N93_RS07235 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) E5N93_RS07245 ENOG4108UQQ Electron transport complex E5N93_RS07255 ENOG4105CSM endonuclease III E5N93_RS07260 ENOG4105DUX Transporter E5N93_RS07265 ENOG4108K3A Glutathione S-transferase E5N93_RS07285 ENOG410642K Lysozyme inhibitor E5N93_RS07295 ENOG4108XTF Outer Membrane Lipoprotein E5N93_RS07310 ENOG4105Y49 secretion protein, HlyD family E5N93_RS07315 ENOG4105DSW Fusaric acid resistance protein E5N93_RS07320 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5N93_RS07325 ENOG4107RGM aldo keto reductase E5N93_RS07330 ENOG4105XZD Fe-S protein E5N93_RS07335 ENOG4108WUH Transcriptional regulator, TetR family E5N93_RS07340 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5N93_RS07345 ENOG4108UYE Lactoylglutathione lyase E5N93_RS07350 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) E5N93_RS07360 ENOG4105M2J Glutaredoxin E5N93_RS07365 ENOG4105K4H Nlp p60 protein E5N93_RS07370 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5N93_RS07385 ENOG4105F52 Transcriptional regulator E5N93_RS07390 ENOG4105CZQ inner membrane transport protein YdhC E5N93_RS07395 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E5N93_RS07400 ENOG4108R6K riboflavin synthase, subunit alpha E5N93_RS07420 ENOG4108IUF type iii secretion E5N93_RS07425 ENOG4108TN6 type iii secretion E5N93_RS07430 ENOG41083GP type iii secretion E5N93_RS07435 ENOG4108HHI Type III secretion system protein E5N93_RS07440 ENOG41063Q7 Type III secretion system protein E5N93_RS07455 ENOG4108JIR Flagellum-specific ATP synthase E5N93_RS07465 ENOG4106H1D secretion system apparatus protein E5N93_RS07470 ENOG4105UQF type iii secretion E5N93_RS07475 ENOG4106563 type III secretion system apparatus protein E5N93_RS07525 ENOG4106FZW pathogenicity island effector protein E5N93_RS07530 ENOG4108SZ7 secretion system effector E5N93_RS07540 ENOG4105ZQI secreted protein E5N93_RS07570 ENOG4105BZU Histidine kinase E5N93_RS07580 ENOG4108XDN Transcriptional regulator E5N93_RS07585 ENOG4107SEY Conserved Protein E5N93_RS07590 ENOG4105RFR Protein of unknown function (DUF2767) E5N93_RS07595 ENOG4108ZXC Two component transcriptional regulator, luxr family E5N93_RS07600 ENOG4106AFQ Histidine kinase E5N93_RS07605 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N93_RS07610 ENOG4106WHD Tetrathionate reductase E5N93_RS07615 ENOG4105DB1 molybdopterin oxidoreductase E5N93_RS07620 ENOG4108RVA ribokinase E5N93_RS07630 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) E5N93_RS07635 ENOG4105CUB amino acid E5N93_RS07640 ENOG4105CA9 Pyruvate kinase E5N93_RS07655 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5N93_RS07670 ENOG4105JRK feS assembly protein SufD E5N93_RS07675 ENOG4105C3K feS assembly ATPase SufC E5N93_RS07680 ENOG4105DIW FeS assembly protein SUFB E5N93_RS07685 ENOG4108Z4V iron-sulfur cluster assembly E5N93_RS07690 ENOG4108ETY sodium dicarboxylate symporter E5N93_RS07695 ENOG410671Z uncharacterized protein ydiH E5N93_RS07700 ENOG4105KA0 thioesterase Superfamily protein E5N93_RS07705 ENOG4105CQB FAD linked oxidase domain protein E5N93_RS07710 ENOG4105IPI Membrane E5N93_RS07720 ENOG4105SUA Ydil protein E5N93_RS07725 ENOG4105EMV Major Facilitator E5N93_RS07730 ENOG4105EMV Major Facilitator E5N93_RS07735 ENOG4105E2X shikimate dehydrogenase E5N93_RS07740 ENOG4105FF2 Type I DHQase E5N93_RS07745 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E5N93_RS07750 ENOG4105C1G acyl-Coa dehydrogenase E5N93_RS07755 ENOG4105W4W Transcriptional regulator E5N93_RS07760 ENOG4105CV7 Electron transfer flavoprotein E5N93_RS07765 ENOG4105C10 Electron transfer flavoprotein E5N93_RS07770 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5N93_RS07775 ENOG41090P5 ferredoxin-like protein E5N93_RS07780 ENOG4105CEY Amp-dependent synthetase and ligase E5N93_RS07785 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) E5N93_RS07795 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5N93_RS07805 ENOG4105CNG UPF0061 protein E5N93_RS07815 ENOG4108QBX (LipO)protein E5N93_RS07825 ENOG4108V06 Glutathione peroxidase E5N93_RS07835 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E5N93_RS07840 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E5N93_RS07860 ENOG41082NX 50s ribosomal protein l35 E5N93_RS07865 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) E5N93_RS07880 ENOG4105K25 O-Antigen polymerase E5N93_RS07905 ENOG4108NE3 Salt-induced outer membrane protein E5N93_RS07910 ENOG4105DE4 1-phosphofructokinase E5N93_RS07915 ENOG4105P10 Uncharacterized protein ydiZ E5N93_RS07925 ENOG4107PN8 YfeABCD locus regulator E5N93_RS07930 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 E5N93_RS07935 ENOG4107K5X Membrane-bound metal-dependent hydrolase E5N93_RS07940 ENOG4108ETY sodium dicarboxylate symporter E5N93_RS07950 ENOG4105CH6 catalase E5N93_RS07955 ENOG410901P UPF0249 protein E5N93_RS07960 ENOG4105F8D glycoside hydrolase family 4 E5N93_RS07965 ENOG4105EZV Transcriptional regulator E5N93_RS07970 ENOG4105VCP PTS System E5N93_RS07975 ENOG4105CK1 PTS System E5N93_RS07980 ENOG4105VZJ PTS System E5N93_RS07990 ENOG4105KKI DNA-binding transcriptional activator OsmE E5N93_RS08000 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) E5N93_RS08005 ENOG4108SPG Periplasmic Protein E5N93_RS08010 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) E5N93_RS08020 ENOG4105C26 Dehydrogenase E5N93_RS08030 ENOG4105C8Y Acetylornithine aminotransferase E5N93_RS08035 ENOG4105CGK Exodeoxyribonuclease III E5N93_RS08040 ENOG4105M6F mutator MutT protein E5N93_RS08045 ENOG4105MTM Protein of unknown function (DUF1496) E5N93_RS08050 ENOG4105D82 Glutamate dehydrogenase E5N93_RS08055 ENOG4108IYH Dna topoisomerase E5N93_RS08060 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) E5N93_RS08065 ENOG41069NU Nitroreductase E5N93_RS08070 ENOG4105D07 Signal peptide peptidase, SppA E5N93_RS08075 ENOG4105HDK L-asparaginase E5N93_RS08080 ENOG4108RWI nicotinamidase E5N93_RS08085 ENOG4105VUT cytoplasmic protein E5N93_RS08095 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E5N93_RS08100 ENOG4105DSB aldose 1-epimerase E5N93_RS08105 ENOG4105CV8 reductase E5N93_RS08110 ENOG4105C4X radical SAM domain protein E5N93_RS08115 ENOG4105GNX MltA-interacting MipA family protein E5N93_RS08120 ENOG4105CYN Serine protein kinase E5N93_RS08135 ENOG4108KHP Diguanylate cyclase E5N93_RS08140 ENOG4108KXH Ybak prolyl-tRNA synthetase associated E5N93_RS08155 ENOG4105R1U AraC Family Transcriptional Regulator E5N93_RS08160 ENOG4105DJ2 Major Facilitator Superfamily E5N93_RS08165 ENOG4105K78 MarR family Transcriptional regulator E5N93_RS08175 ENOG4105UCG Domain of unknown function (DUF333) E5N93_RS08180 ENOG4106G4W E5N93_RS08185 ENOG4105Y3U Transglycosylase-associated protein E5N93_RS08200 ENOG4105YP6 Domain of unknown function (DUF1869) E5N93_RS08205 ENOG4108YS1 cytoplasmic protein E5N93_RS08215 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) E5N93_RS08230 ENOG4108Z6Z Transcriptional regulator E5N93_RS08245 ENOG4108MEK Metal-binding protein YodA E5N93_RS08260 ENOG4105D64 Mechanosensitive ion channel E5N93_RS08265 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E5N93_RS08270 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E5N93_RS08280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E5N93_RS08295 ENOG4108VKM cytochrome b561 E5N93_RS08305 ENOG4108ZNX Heat shock protein E5N93_RS08330 ENOG4105H38 Membrane E5N93_RS08345 ENOG41060EU Cold shock-like protein E5N93_RS08350 ENOG4106F2Y RICIN E5N93_RS08355 ENOG4105Y50 Virulence Protein E5N93_RS08375 ENOG4108HMX isocitrate dehydrogenase (NADP) E5N93_RS08380 ENOG4108R99 pseudouridine synthase E5N93_RS08395 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) E5N93_RS08405 ENOG4107QTF adenylosuccinate lyase E5N93_RS08420 ENOG4105EZE Cupin 4 family protein E5N93_RS08435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E5N93_RS08450 ENOG4105D38 putrescine abc transporter E5N93_RS08455 ENOG4108HM4 ABC transporter E5N93_RS08460 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E5N93_RS08470 ENOG4105D60 lipoprotein releasing system transmembrane protein E5N93_RS08475 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E5N93_RS08480 ENOG4105D60 lipoprotein releasing system transmembrane protein E5N93_RS08485 ENOG4108JA2 transcriptioN-repair coupling factor E5N93_RS08490 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5N93_RS08495 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction E5N93_RS08500 ENOG4108IND Tetr family transcriptional regulator E5N93_RS08505 ENOG4107MBR 17 kDa surface antigen E5N93_RS08510 ENOG4105CEP NADH dehydrogenase E5N93_RS08525 ENOG4108RUM thiamine kinase E5N93_RS08530 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) E5N93_RS08535 ENOG41090DQ Lipoprotein E5N93_RS08540 ENOG4105K59 histidine triad (HIT) protein E5N93_RS08545 ENOG4105CNM Receptor E5N93_RS08550 ENOG4105CI1 PTS System E5N93_RS08555 ENOG4105F8V Hydrolase, tatD family E5N93_RS08560 ENOG4107QRG dna polymerase iii E5N93_RS08570 ENOG4105HHA aminodeoxychorismate lyase E5N93_RS08575 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E5N93_RS08580 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E5N93_RS08585 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E5N93_RS08590 ENOG4105CHR reductase E5N93_RS08595 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E5N93_RS08600 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) E5N93_RS08615 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E5N93_RS08620 ENOG4108UHJ MAF-like protein E5N93_RS08635 ENOG4105EI2 Pseudouridine synthase E5N93_RS08640 ENOG41071G1 Uncharacterized protein YceQ E5N93_RS08645 ENOG4107QQB Ribonuclease E E5N93_RS08650 ENOG4105DTJ flagellar hook-associated protein E5N93_RS08655 ENOG4105E1Q flagellar hook-associated protein E5N93_RS08660 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj E5N93_RS08675 ENOG4105CGA flagellar basal-body rod protein FlgG E5N93_RS08680 ENOG4108KPB Flagellar basal-body rod protein FlgF E5N93_RS08685 ENOG4105BZE flagellar hook protein, FlgE E5N93_RS08690 ENOG4105W00 Flagellar hook capping protein E5N93_RS08695 ENOG4108ZC9 flagellar basal-body rod protein flgc E5N93_RS08700 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) E5N93_RS08705 ENOG4105CKS Flagella basal body P-ring formation protein flgA E5N93_RS08710 ENOG4105M9M anti-sigma28 factor FlgM E5N93_RS08715 ENOG4105QVD Flagella synthesis protein FlgN E5N93_RS08720 ENOG4105CJR Integral membrane protein (MviN E5N93_RS08725 ENOG4105EP9 oxidoreductase E5N93_RS08735 ENOG4105D9U N-acetyltransferase E5N93_RS08745 ENOG4105E9S glutaredoxin 2 E5N93_RS08750 ENOG4105F3T (LipO)protein E5N93_RS08755 ENOG4105EKE dihydroorotase E5N93_RS08760 ENOG4105MEA DNA damage-inducible protein i E5N93_RS08765 ENOG4105PVA Biofilm formation regulatory protein BssS E5N93_RS08770 ENOG4105F76 Sarcosine oxidase E5N93_RS08775 ENOG4106974 biofilm formation E5N93_RS08780 ENOG4105DS1 cytochrome b561 E5N93_RS08785 ENOG4108YYC ycei family E5N93_RS08790 ENOG4105C72 UPF0176 protein E5N93_RS08795 ENOG4105D1S lipid A biosynthesis E5N93_RS08800 ENOG4105C6X Major Facilitator E5N93_RS08805 ENOG4108W47 Acidic protein msyB E5N93_RS08810 ENOG4105NAC (LipO)protein E5N93_RS08815 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) E5N93_RS08830 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) E5N93_RS08835 ENOG4107RZC phospholipase d E5N93_RS08840 ENOG4108UVJ appr-1-p processing domain protein E5N93_RS08845 ENOG41068SS E5N93_RS08850 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) E5N93_RS08855 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin E5N93_RS08860 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers E5N93_RS08865 ENOG41086KC Transcriptional regulator E5N93_RS08870 ENOG4108XDW curli assembly protein CsgE E5N93_RS08875 ENOG4108WYR Curli production assembly transport component, CsgF E5N93_RS08880 ENOG4105P8Q Curli production assembly transport component CsgG E5N93_RS08885 ENOG4108UQ5 membrane protein YcdZ E5N93_RS08890 ENOG4107XHZ cytoplasmic chaperone TorD family protein E5N93_RS08915 ENOG4107RJ5 oxidoreductase E5N93_RS08920 ENOG4105JHE Major Facilitator Superfamily E5N93_RS08925 ENOG4108QGT oligogalacturonate-specific porin E5N93_RS08930 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) E5N93_RS08935 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) E5N93_RS08940 ENOG4107RJ1 sodium solute E5N93_RS08945 ENOG4105QEK Transcriptional regulator E5N93_RS08950 ENOG4105D5M phosphate starvation-inducible protein E5N93_RS08955 ENOG4105CK7 Sodium proline symporter E5N93_RS08970 ENOG4108R86 Transcriptional regulator E5N93_RS08975 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 E5N93_RS08985 ENOG4105XH3 E5N93_RS08990 ENOG4105D6F Phosphatase E5N93_RS08995 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E5N93_RS09000 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E5N93_RS09005 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E5N93_RS09050 ENOG4105CNV Aldolase E5N93_RS09065 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase E5N93_RS09070 ENOG4105C26 Dehydrogenase E5N93_RS09080 ENOG4108V8F Transcriptional regulator, MarR family E5N93_RS09085 ENOG4105EFA 4-hydroxyphenylacetate E5N93_RS09090 ENOG4107UWN reductase E5N93_RS09095 ENOG4105VT2 5-hydroxyisourate hydrolase E5N93_RS09100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5N93_RS09105 ENOG4107ZY3 Histidine kinase E5N93_RS09120 ENOG4106YSC E5N93_RS09125 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell E5N93_RS09130 ENOG4106HNN Invasion protein E5N93_RS09140 ENOG41084BJ Pentapeptide repeat protein E5N93_RS09155 ENOG4108MN8 Membrane E5N93_RS09165 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 E5N93_RS09175 ENOG4108V1U phospholipid-binding protein E5N93_RS09190 ENOG4105K4P CoA-binding domain protein E5N93_RS09200 ENOG4108Z5K methylglyoxal synthase E5N93_RS09205 ENOG41088T4 Helicase IV E5N93_RS09210 ENOG410901E Membrane E5N93_RS09215 ENOG4105EM2 membrane E5N93_RS09220 ENOG4108RZ1 DNA transformation protein E5N93_RS09230 ENOG4105UYK outer membrane protein a E5N93_RS09240 ENOG4105DAN ATP-dependent protease E5N93_RS09250 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) E5N93_RS09255 ENOG4108Q2G (LipO)protein E5N93_RS09260 ENOG4105DY2 Paraquat-inducible protein b E5N93_RS09265 ENOG4105F1S paraquat-inducible protein a E5N93_RS09270 ENOG4105C5H ABC transporter E5N93_RS09280 ENOG4105QVC MOSC domain-containing protein E5N93_RS09285 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) E5N93_RS09295 ENOG4105CD8 aminopeptidase N E5N93_RS09300 ENOG4105Y50 Virulence Protein E5N93_RS09315 ENOG4108RAV Conserved protein E5N93_RS09325 ENOG4106EE1 E5N93_RS09335 ENOG4105UZW Tail fiber assembly protein E5N93_RS09340 ENOG4108X9F tail fiber protein E5N93_RS09375 ENOG4108T1M outer membrane protein x E5N93_RS09400 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 E5N93_RS09500 ENOG4105JBR DNA replication protein E5N93_RS09535 ENOG41076J9 exonuclease VIII E5N93_RS09555 ENOG4107R08 Integrase E5N93_RS09560 ENOG4107RH7 Nicotinate phosphoribosyltransferase E5N93_RS09570 ENOG4107RCH Diaminopropionate ammonia-lyase E5N93_RS09585 ENOG4105C5S asparaginyl-tRNA synthetase E5N93_RS09590 ENOG4105FCK Membrane E5N93_RS09595 ENOG4105CGF Aromatic amino acid aminotransferase E5N93_RS09600 ENOG4105C5X domain protein E5N93_RS09605 ENOG4105EAQ (twin-arginine translocation) pathway signal E5N93_RS09610 ENOG4105DIT ErfK YbiS YcfS YnhG family protein E5N93_RS09620 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) E5N93_RS09625 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) E5N93_RS09635 ENOG4106371 Methyltransferase E5N93_RS09640 ENOG4107S90 membrAne E5N93_RS09645 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups E5N93_RS09665 ENOG4105T0Z Conserved Protein E5N93_RS09675 ENOG4105BZ1 (ABC) transporter E5N93_RS09680 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 E5N93_RS09685 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E5N93_RS09690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E5N93_RS09695 ENOG4105CAT Cytidine monophosphate kinase E5N93_RS09700 ENOG4108K0D peptidase, M48 E5N93_RS09705 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase E5N93_RS09715 ENOG4107VMU Membrane E5N93_RS09720 ENOG4105DDY UPF0142 protein ycaO E5N93_RS09725 ENOG4105TMB Formate nitrite transporter E5N93_RS09730 ENOG4105C6N Formate acetyltransferase E5N93_RS09735 ENOG4105GUS E5N93_RS09745 ENOG4105F1A Pyruvate formate-lyase E5N93_RS09750 ENOG4105E5D amino acid E5N93_RS09760 ENOG4107KGK dmso reductase anchor subunit E5N93_RS09765 ENOG4105QAX Iron-sulfur E5N93_RS09770 ENOG4107QY8 reductase E5N93_RS09780 ENOG4105D1H recombination factor protein RarA E5N93_RS09790 ENOG4105CNU cell division protein FtsK E5N93_RS09795 ENOG4105EW9 transcriptional regulator AsnC family E5N93_RS09800 ENOG4105C3M thioredoxin reductase E5N93_RS09805 ENOG4108JJ9 ABC, transporter E5N93_RS09810 ENOG4108JJ8 (ABC) transporter E5N93_RS09825 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) E5N93_RS09830 ENOG4105HEI LysR family (Transcriptional regulator E5N93_RS09835 ENOG4105EUB pirin domain protein E5N93_RS09840 ENOG4105CHJ isochorismatase hydrolase E5N93_RS09865 ENOG4108RS6 transposase E5N93_RS09870 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5N93_RS09880 ENOG4105VEQ Cold shock protein E5N93_RS09885 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E5N93_RS09890 ENOG4105DJY efflux transporter, rnd family, mfp subunit E5N93_RS09895 ENOG4108MJ5 VirK protein E5N93_RS09900 ENOG4105CPB ATP-dependent endonuclease of the OLD family E5N93_RS09905 ENOG4105DWU Membrane E5N93_RS09910 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) E5N93_RS09915 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E5N93_RS09920 ENOG4105C7K acetolactate synthase E5N93_RS09925 ENOG4105C5W Aldolase E5N93_RS09930 ENOG4105CGD Nad-dependent epimerase dehydratase E5N93_RS09935 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase E5N93_RS09940 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E5N93_RS09950 ENOG41064MM (LipO)protein E5N93_RS09955 ENOG4105E5Z arginine transporter ATP-binding subunit E5N93_RS09960 ENOG4106PMH Extracellular solute-binding protein family 3 E5N93_RS09965 ENOG4105GBT ABC transporter E5N93_RS09970 ENOG4105DMR ABC, transporter E5N93_RS09975 ENOG4106TNF Periplasmic binding protein E5N93_RS09995 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) E5N93_RS10000 ENOG4105RBQ inner membrane protein ybjO E5N93_RS10005 ENOG4105D38 putrescine abc transporter E5N93_RS10010 ENOG4105F38 ABC transporter, permease E5N93_RS10015 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E5N93_RS10020 ENOG4107RUE extracellular solute-binding protein family 1 E5N93_RS10025 ENOG4108RMJ sensory transduction regulator E5N93_RS10035 ENOG4108DBC nitroreductase E5N93_RS10040 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress E5N93_RS10045 ENOG41090BQ Glutaredoxin E5N93_RS10050 ENOG4105GWF inner membrane protein YbjM E5N93_RS10065 ENOG4108RFG Tetr family transcriptional regulator E5N93_RS10070 ENOG4106UW1 Major Facilitator superfamily E5N93_RS10075 ENOG4108HCJ Hydrolase E5N93_RS10080 ENOG4107QF7 multi-drug E5N93_RS10085 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E5N93_RS10090 ENOG4107FB0 transcriptional regulator DeoR family E5N93_RS10095 ENOG4105DZ1 carboxypeptidase E5N93_RS10100 ENOG4108TGY Glutathione S-transferase E5N93_RS10105 ENOG4105D8V Glucose sorbosone dehydrogenase E5N93_RS10110 ENOG4105CY2 Citrate transporter E5N93_RS10115 ENOG4108KB2 LysR family Transcriptional regulator E5N93_RS10120 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5N93_RS10130 ENOG4105C1G acyl-Coa dehydrogenase E5N93_RS10140 ENOG4105C10 Electron transfer flavoprotein E5N93_RS10145 ENOG4105BZJ Electron transfer flavoprotein E5N93_RS10150 ENOG4105CI0 Citrate lyase E5N93_RS10155 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway E5N93_RS10170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E5N93_RS10175 ENOG4105DEF Extracellular solute-binding protein, family 5 E5N93_RS10180 ENOG4108JQ6 ABC transporter E5N93_RS10185 ENOG4105D44 asparaginase E5N93_RS10190 ENOG4105CVM Molybdenum cofactor synthesis domain protein E5N93_RS10195 ENOG4105D06 uba thif-type nad fad binding protein E5N93_RS10200 ENOG4105F1A Pyruvate formate-lyase E5N93_RS10210 ENOG4108HCJ Hydrolase E5N93_RS10215 ENOG41072TH Protein of unknown function (DUF1479) E5N93_RS10230 ENOG4105C5H ABC transporter E5N93_RS10235 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5N93_RS10240 ENOG4105F4P )-transporter E5N93_RS10245 ENOG4105KST dependent repressor E5N93_RS10255 ENOG4108I6E Sulfatase E5N93_RS10260 ENOG4108T1M outer membrane protein x E5N93_RS10275 ENOG4107R0W ABC transporter E5N93_RS10280 ENOG4105E5Q amino acid AbC transporter E5N93_RS10285 ENOG4105CDA abc transporter atp-binding protein E5N93_RS10290 ENOG4105D8X mechanosensitive ion channel E5N93_RS10300 ENOG4105KSC Transcriptional regulator, TraR DksA family E5N93_RS10305 ENOG4105VR4 UPF0379 protein ybiJ E5N93_RS10310 ENOG4108MTB glycosyl transferase family E5N93_RS10315 ENOG4105DVT helicase E5N93_RS10320 ENOG4105C1J atp-dependent rna helicase E5N93_RS10325 ENOG4107MVR Transcriptional regulator E5N93_RS10335 ENOG4105CJ1 ABC, transporter E5N93_RS10340 ENOG4107QWP ABC-2 type transporter E5N93_RS10345 ENOG4107QWP ABC-2 type transporter E5N93_RS10350 ENOG4105I9U inner membrane protein ybhQ E5N93_RS10355 ENOG4105X23 Endonuclease Exonuclease phosphatase E5N93_RS10360 ENOG4105DZQ phospholipase D Transphosphatidylase E5N93_RS10365 ENOG4107UXM Membrane E5N93_RS10390 ENOG4108RS6 transposase E5N93_RS10395 ENOG4108C80 FliB family E5N93_RS10400 ENOG4105I03 Flagellin E5N93_RS10405 ENOG4105DTS flagellar hook-associated E5N93_RS10410 ENOG4105MQ3 flagellar protein FliS E5N93_RS10420 ENOG4105E5K Alpha-amylase E5N93_RS10425 ENOG4105JCU Inherit from NOG: (Lipo)protein E5N93_RS10430 ENOG41066VF YeeE YedE family protein E5N93_RS10450 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) E5N93_RS10455 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E5N93_RS10460 ENOG41090PJ Flagellar assembly protein E5N93_RS10465 ENOG4108JIR Flagellum-specific ATP synthase E5N93_RS10470 ENOG4105GSA Flagellar export protein flij E5N93_RS10475 ENOG4105WF4 Flagellar hook-length control protein E5N93_RS10480 ENOG4107ZI8 flagellar basal body-associated protein flil E5N93_RS10485 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E5N93_RS10490 ENOG4105DD5 Flagellar motor switch protein E5N93_RS10495 ENOG4105K0P flagellar biosynthesis protein E5N93_RS10500 ENOG4105CN7 Flagellar biosynthetic protein FliP E5N93_RS10505 ENOG4105VS8 Flagellar biosynthetic protein fliq E5N93_RS10510 ENOG4105D19 Role in flagellar biosynthesis (By similarity) E5N93_RS10515 ENOG4107TKS colanic acid capsular biosynthesis activation protein A E5N93_RS10525 ENOG4105YX3 cellular response to acidity E5N93_RS10530 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase E5N93_RS10535 ENOG4105BZU Histidine kinase E5N93_RS10540 ENOG4105VNZ cytoplasmic protein E5N93_RS10545 ENOG4105CKW Inner membrane protein yedI E5N93_RS10550 ENOG4105FDR Membrane E5N93_RS10555 ENOG41090BB DNA mismatch endonuclease (vsr) E5N93_RS10560 ENOG4105DVF Cytosine-specific methyltransferase E5N93_RS10565 ENOG4105EST Metal Dependent Phosphohydrolase E5N93_RS10570 ENOG4105Y0K Inner membrane protein YedR E5N93_RS10575 ENOG4105FCK Membrane E5N93_RS10590 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E5N93_RS10595 ENOG4105KT5 UmuD protein E5N93_RS10635 ENOG4105W3V DNA-binding, transcriptional regulator E5N93_RS10640 ENOG4105UZW Tail fiber assembly protein E5N93_RS10645 ENOG4105Y9F tail fiber protein E5N93_RS10650 ENOG4105Y0G tail protein E5N93_RS10655 ENOG4108T86 baseplate J family protein E5N93_RS10700 ENOG4105TKZ Tail Sheath E5N93_RS10745 ENOG4105EFC phage portal protein HK97 family E5N93_RS10755 ENOG4105CAR Terminase, large subunit E5N93_RS10785 ENOG4105NVB glycoside hydrolase, family 19 E5N93_RS10810 ENOG4105HGD Antitermination protein E5N93_RS10815 ENOG4108MXB Protein of unknown function (DUF968) E5N93_RS10825 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) E5N93_RS10830 ENOG4105DFE Dna adenine methylase E5N93_RS10850 ENOG4106050 phage regulatory protein, rha family E5N93_RS10855 ENOG4108S1U E5N93_RS10885 ENOG4105H40 E5N93_RS10890 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) E5N93_RS10895 ENOG4108R7K Metal Dependent Phosphohydrolase E5N93_RS11000 ENOG4105FYV Amp nucleosidase E5N93_RS11025 ENOG4105UQX Mate efflux family protein E5N93_RS11035 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5N93_RS11050 ENOG4108YZT Adenosylcobinamide kinase E5N93_RS11055 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E5N93_RS11060 ENOG4108JJB ABC transporter E5N93_RS11065 ENOG4108V4M Cobalt abc transporter E5N93_RS11070 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) E5N93_RS11075 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) E5N93_RS11080 ENOG4105DVK Precorrin-2 c20-methyltransferase E5N93_RS11085 ENOG4107PPM cobalt chelatase E5N93_RS11090 ENOG4105QUC reductase E5N93_RS11095 ENOG4105E4R Precorrin-3B C17-methyltransferase E5N93_RS11100 ENOG4108P62 biosynthesis protein (CbiG) E5N93_RS11105 ENOG4105CIA precorrin-4 C(11)-methyltransferase E5N93_RS11110 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase E5N93_RS11115 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase E5N93_RS11125 ENOG41081F0 Precorrin-8x methylmutase E5N93_RS11130 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) E5N93_RS11135 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E5N93_RS11140 ENOG4107XVH Transcriptional regulator E5N93_RS11145 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E5N93_RS11150 ENOG4105KNY Microcompartments protein E5N93_RS11155 ENOG4105EHR propanediol utilization protein pduB E5N93_RS11160 ENOG4105DMB glycerol dehydratase E5N93_RS11165 ENOG4105YCI dehydratase medium subunit E5N93_RS11170 ENOG4108ZFT Dehydratase small subunit E5N93_RS11175 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E5N93_RS11185 ENOG4105KNY Microcompartments protein E5N93_RS11195 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) E5N93_RS11205 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E5N93_RS11215 ENOG4108EKI Dehydrogenase E5N93_RS11220 ENOG4105C0A alcohol dehydrogenase E5N93_RS11225 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) E5N93_RS11235 ENOG4105M3W utilization protein E5N93_RS11240 ENOG4105KTW ethanolamine utilization protein E5N93_RS11245 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E5N93_RS11250 ENOG4105JZC GHMP kinase E5N93_RS11255 ENOG41090HJ UPF0265 protein E5N93_RS11260 ENOG4105DR8 Membrane E5N93_RS11265 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) E5N93_RS11270 ENOG4105DZ1 carboxypeptidase E5N93_RS11275 ENOG4108NWD Cytochrome E5N93_RS11280 ENOG4105QAX Iron-sulfur E5N93_RS11285 ENOG4108J2R molybdopterin oxidoreductase E5N93_RS11300 ENOG4105CJB Exodeoxyribonuclease I E5N93_RS11305 ENOG4105CUB amino acid E5N93_RS11315 ENOG4105EQ1 Transcriptional regulator E5N93_RS11320 ENOG4107SRH Nad-dependent epimerase dehydratase E5N93_RS11335 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E5N93_RS11340 ENOG4105CIH Imidazole acetol-phosphate transaminase E5N93_RS11345 ENOG4105ECC imidazole-glycerol-phosphate dehydratase E5N93_RS11350 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E5N93_RS11365 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E5N93_RS11370 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) E5N93_RS11375 ENOG4105C6Y Udp-glucose 6-dehydrogenase E5N93_RS11380 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) E5N93_RS11385 ENOG4105D3Q Sugar transferase E5N93_RS11390 ENOG4106ECQ phosphomannomutase E5N93_RS11395 ENOG4105CJT Mannose-1-phosphate guanylyltransferase E5N93_RS11400 ENOG4108KBE Glycosyl transferase, family 2 E5N93_RS11405 ENOG4108TJN glycosyl transferase group 1 E5N93_RS11410 ENOG4107YYJ Glycosyl transferase, family 2 E5N93_RS11415 ENOG4105FB1 Polysaccharide Biosynthesis Protein E5N93_RS11420 ENOG4108SMP Nad-dependent epimerase dehydratase E5N93_RS11425 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E5N93_RS11430 ENOG4105FAW cDP-glucose 4,6-dehydratase E5N93_RS11435 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase E5N93_RS11440 ENOG4107QK7 reductase E5N93_RS11445 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase E5N93_RS11450 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E5N93_RS11455 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase E5N93_RS11460 ENOG4105C1B dTDP-glucose 4-6-dehydratase E5N93_RS11465 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E5N93_RS11470 ENOG4105G1A colanic acid biosynthesis protein E5N93_RS11475 ENOG4107T8Q Glycosyl transferase (Group 1 E5N93_RS11480 ENOG4105C74 pyruvyl transferase E5N93_RS11485 ENOG4105PSV Polysaccharide Biosynthesis Protein E5N93_RS11490 ENOG4105D3Q Sugar transferase E5N93_RS11495 ENOG4107QKV phosphomannomutase E5N93_RS11500 ENOG4105CJT Mannose-1-phosphate guanylyltransferase E5N93_RS11505 ENOG4106CD9 glycosyl transferase group 1 E5N93_RS11510 ENOG4105FGF GDP-mannose mannosyl hydrolase E5N93_RS11515 ENOG4105C30 Nad-dependent epimerase dehydratase E5N93_RS11520 ENOG4105C0K Gdp-mannose 4,6-dehydratase E5N93_RS11525 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF E5N93_RS11530 ENOG4105ECJ Glycosyl Transferase E5N93_RS11535 ENOG4108NYJ Colanic acid E5N93_RS11540 ENOG4107RXY Glycosyl transferase E5N93_RS11545 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB E5N93_RS11550 ENOG41090RK glycosyl transferase E5N93_RS11555 ENOG4105D75 Capsular exopolysaccharide family E5N93_RS11560 ENOG4105KJF protein tyrosine phosphatase E5N93_RS11565 ENOG4105DAY polysaccharide export protein E5N93_RS11570 ENOG4105EE5 Membrane protein terC E5N93_RS11575 ENOG4108GAE asmA family E5N93_RS11590 ENOG4105BZU Histidine kinase E5N93_RS11595 ENOG4105D03 DNA-3-methyladenine glycosylase II E5N93_RS11600 ENOG4105R8A Heat shock protein E5N93_RS11610 ENOG4105ENT Efflux transporter rnd family, mfp subunit E5N93_RS11615 ENOG4105BZS acriflavin resistance protein E5N93_RS11620 ENOG4105BZS acriflavin resistance protein E5N93_RS11625 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N93_RS11630 ENOG4105EB3 Histidine kinase E5N93_RS11635 ENOG4105E3W Two component transcriptional regulator (Winged helix family E5N93_RS11655 ENOG4105CFP Peptidase U32 E5N93_RS11665 ENOG41090V3 Tir chaperone protein (CesT) family E5N93_RS11680 ENOG4105EIE fructose-bisphosphate aldolase E5N93_RS11685 ENOG4105EAA nucleoside E5N93_RS11690 ENOG4108KD5 ADP-ribosylation crystallin J1 E5N93_RS11695 ENOG4108TFM Kinase, PfkB family E5N93_RS11700 ENOG4105FDP GntR family transcriptional regulator E5N93_RS11705 ENOG4105DWF phosphomethylpyrimidine kinase E5N93_RS11715 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly E5N93_RS11720 ENOG410662B Type-1 fimbrial protein E5N93_RS11725 ENOG4105CW0 outer membrane usher protein E5N93_RS11730 ENOG4108MQF Chaperone E5N93_RS11745 ENOG4105D1F ATP-binding protein E5N93_RS11755 ENOG4108YCW (LipO)protein E5N93_RS11765 ENOG4108W15 Protein of unknown function (DUF1456) E5N93_RS11770 ENOG4108NEV two component transcriptional regulator, LytTR family E5N93_RS11775 ENOG4108HRK Histidine kinase E5N93_RS11790 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component E5N93_RS11795 ENOG4108IJ8 ABC transporter E5N93_RS11800 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component E5N93_RS11805 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E5N93_RS11810 ENOG4107QK4 glycoside hydrolase, family 3 domain protein E5N93_RS11815 ENOG4105CXG d-lactate dehydrogenase E5N93_RS11820 ENOG41061WM D-Alanyl-D-Alanine E5N93_RS11825 ENOG41069YE inner membrane protein yohC E5N93_RS11830 ENOG4105KHU inner membrane protein YohD E5N93_RS11835 ENOG4105H9W Short-chain dehydrogenase reductase Sdr E5N93_RS11840 ENOG4105ETP RND efflux system, outer membrane lipoprotein E5N93_RS11850 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E5N93_RS11855 ENOG4105MSY salicylate hydroxylase E5N93_RS11860 ENOG4108RXX maleylacetoacetate isomerase E5N93_RS11890 ENOG41067MG lrgb family E5N93_RS11900 ENOG4107GZ4 SanA protein E5N93_RS11905 ENOG4105Y9N Membrane E5N93_RS11910 ENOG4105BZ8 glutamate synthase E5N93_RS11915 ENOG4107SJI Dehydrogenase E5N93_RS11920 ENOG4107SDZ Galactoside transport system permease protein mglC E5N93_RS11925 ENOG4105C2J ABC transporter E5N93_RS11930 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator E5N93_RS11935 ENOG41060NJ transcriptional regulator E5N93_RS11940 ENOG4105DHF Membrane E5N93_RS11945 ENOG4105EUJ GTP cyclohydrolase i E5N93_RS11960 ENOG4105EJQ L-serine dehydratase E5N93_RS11965 ENOG4105EAC phosphoserine phosphatase E5N93_RS11970 ENOG4105CXY transporter E5N93_RS11975 ENOG4105D05 Receptor E5N93_RS11980 ENOG4108IQI permease E5N93_RS11985 ENOG4105DUM transcriptional regulator, lysR family E5N93_RS11990 ENOG4105HMI Membrane E5N93_RS12000 ENOG4105DM4 PTS System E5N93_RS12005 ENOG4105DE4 1-phosphofructokinase E5N93_RS12010 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E5N93_RS12015 ENOG4105S8Q sugar efflux transporter E5N93_RS12030 ENOG4105KRS Proteinase inhibitor E5N93_RS12035 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E5N93_RS12040 ENOG4105CKI cobalamin synthesis protein E5N93_RS12045 ENOG41076MN Phosphoesterase, PA-phosphatase related E5N93_RS12050 ENOG4107TT5 NLP P60 protein E5N93_RS12055 ENOG4105CXC rtn protein E5N93_RS12060 ENOG4105E43 Extracellular solute-binding protein, family 5 E5N93_RS12065 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E5N93_RS12070 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E5N93_RS12075 ENOG4108JQ5 ABC transporter E5N93_RS12080 ENOG4105HG6 E5N93_RS12085 ENOG4105C2C drug resistance transporter, Bcr CflA E5N93_RS12090 ENOG4105I08 Pseudouridine synthase E5N93_RS12095 ENOG4105CFI type iii restriction protein res subunit E5N93_RS12120 ENOG4105E68 Sulfatase E5N93_RS12130 ENOG4105KT5 UmuD protein E5N93_RS12135 ENOG4105Y50 Virulence Protein E5N93_RS12145 ENOG4105EXC Acyl-transferase E5N93_RS12150 ENOG4105PTU response to oxidative stress E5N93_RS12160 ENOG4105Y9F tail fiber protein E5N93_RS12185 ENOG4105HRS Antitermination protein E5N93_RS12190 ENOG4108MXB Protein of unknown function (DUF968) E5N93_RS12210 ENOG4108X9F tail fiber protein E5N93_RS12225 ENOG4105WH1 Two component transcriptional regulator luxr family E5N93_RS12230 ENOG4105KWW Biogenesis protein E5N93_RS12235 ENOG4107QX9 Thiol disulfide interChange protein E5N93_RS12250 ENOG4105X3C heme exporter protein E5N93_RS12255 ENOG41060IM Heme exporter protein E5N93_RS12260 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E5N93_RS12265 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E5N93_RS12270 ENOG4105CUW cytochrome C-TYPE protein E5N93_RS12275 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) E5N93_RS12280 ENOG4105GXZ Ferredoxin-type protein NapH E5N93_RS12285 ENOG4108BGM Quinol dehydrogenase periplasmic component E5N93_RS12295 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase E5N93_RS12300 ENOG4108ZNS ferredoxin-type protein NapF E5N93_RS12310 ENOG4105IBP Cyclic peptide transporter E5N93_RS12315 ENOG4105CF1 Alkylated DNA repair protein E5N93_RS12320 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E5N93_RS12325 ENOG4105CJ2 (LipO)protein E5N93_RS12330 ENOG4105FCK Membrane E5N93_RS12335 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC E5N93_RS12340 ENOG41068CG regulatoR E5N93_RS12345 ENOG4105BZU Histidine kinase E5N93_RS12350 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5N93_RS12355 ENOG4105CXK mandelate racemase muconate lactonizing E5N93_RS12375 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5N93_RS12380 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5N93_RS12385 ENOG4105XPH Ferredoxin E5N93_RS12390 ENOG4105CZM Major Facilitator E5N93_RS12395 ENOG4105GZI Transcriptional regulator E5N93_RS12400 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E5N93_RS12405 ENOG4105CXY transporter E5N93_RS12410 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A E5N93_RS12420 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) E5N93_RS12425 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is E5N93_RS12440 ENOG4105CSP Major Facilitator Superfamily E5N93_RS12445 ENOG4105CXK mandelate racemase muconate lactonizing E5N93_RS12450 ENOG4107258 Transcriptional regulator E5N93_RS12455 ENOG4108EWA cinA-like protein E5N93_RS12460 ENOG4108UII YfaZ family E5N93_RS12485 ENOG4105C3I Nad-dependent epimerase dehydratase E5N93_RS12490 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) E5N93_RS12495 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) E5N93_RS12510 ENOG4106GZG polymyxin resistance protein B E5N93_RS12515 ENOG4105CEY Amp-dependent synthetase and ligase E5N93_RS12520 ENOG4105DNI Converts SHCHC to OSB (By similarity) E5N93_RS12525 ENOG4108IPT Naphthoate synthase E5N93_RS12530 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) E5N93_RS12540 ENOG4105E4F Isochorismate synthase E5N93_RS12545 ENOG4105TNS Conserved Protein E5N93_RS12550 ENOG4107YB6 acetyltransferase, (GNAT) family E5N93_RS12565 ENOG4105CP2 von willebrand factor, type a E5N93_RS12580 ENOG4105C8S subunit m E5N93_RS12585 ENOG4105D65 subunit l E5N93_RS12595 ENOG4107UFS subunit j E5N93_RS12610 ENOG4108IEH NADH dehydrogenase subunit g E5N93_RS12615 ENOG4107QIZ NADH dehydrogenase E5N93_RS12620 ENOG4105GKE subunit e E5N93_RS12630 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E5N93_RS12635 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain E5N93_RS12645 ENOG4107NQ8 LysR family Transcriptional regulator E5N93_RS12650 ENOG4105CHM Aminotransferase E5N93_RS12665 ENOG4107QWE )-transporter E5N93_RS12670 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 E5N93_RS12685 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E5N93_RS12690 ENOG4105C6K Malic enzyme E5N93_RS12695 ENOG4105CSX c4-dicarboxylate anaerobic carrier E5N93_RS12700 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E5N93_RS12705 ENOG4108HHA Transketolase E5N93_RS12710 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E5N93_RS12720 ENOG4106ETB IIa component E5N93_RS12725 ENOG4105K2J Transcriptional regulator E5N93_RS12730 ENOG4105PTV Nudix Hydrolase E5N93_RS12735 ENOG4108RE9 Phosphodiesterase E5N93_RS12740 ENOG4108SHQ Glutathione S-transferase E5N93_RS12745 ENOG4105CYM Glutathione S-transferase E5N93_RS12750 ENOG4105ECP epimerase E5N93_RS12755 ENOG4108JEH abc transporter atp-binding protein E5N93_RS12760 ENOG4106YG3 ABC transporter E5N93_RS12765 ENOG4105DSP amino acid AbC transporter E5N93_RS12770 ENOG4105E89 ABC transporter E5N93_RS12775 ENOG4105E89 ABC transporter E5N93_RS12780 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E5N93_RS12790 ENOG4106M28 alanine racemase domain protein E5N93_RS12795 ENOG4105E5D amino acid E5N93_RS12805 ENOG4108JUB Transcriptional regulator E5N93_RS12810 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E5N93_RS12815 ENOG4105E96 Colicin v production protein E5N93_RS12820 ENOG4108S3P Sporulation domain protein E5N93_RS12825 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E5N93_RS12835 ENOG4105DQR SNARE associated Golgi E5N93_RS12840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) E5N93_RS12845 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E5N93_RS12855 ENOG4106WZ1 flagella biosynthesis regulator E5N93_RS12860 ENOG4105F9N Major Facilitator Superfamily E5N93_RS12870 ENOG4105R8V Transcriptional regulator E5N93_RS12890 ENOG4108RS6 transposase E5N93_RS12895 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E5N93_RS12900 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) E5N93_RS12905 ENOG4105MH2 YfcL protein E5N93_RS12910 ENOG4108BPE -transporting atpase E5N93_RS12915 ENOG4105EJ9 Membrane E5N93_RS12930 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E5N93_RS12940 ENOG4108BY2 phosphohistidine phosphatase E5N93_RS12945 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E5N93_RS12950 ENOG4105CHU acetyl-coa acetyltransferase E5N93_RS12955 ENOG4105KZW UPF0381 protein E5N93_RS12960 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation E5N93_RS12965 ENOG410903C (LipO)protein E5N93_RS12970 ENOG4105S64 Formate nitrite transporter E5N93_RS12980 ENOG4108NC2 Outer membrane protease E5N93_RS12985 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta E5N93_RS12995 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC E5N93_RS13000 ENOG4105CXY transporter E5N93_RS13005 ENOG4105W9M Membrane E5N93_RS13010 ENOG4105D1S lipid A biosynthesis E5N93_RS13020 ENOG4105CHM Aminotransferase E5N93_RS13035 ENOG4107RA9 decarboxylase E5N93_RS13040 ENOG4105CPC Aldo Keto reductase E5N93_RS13045 ENOG4109076 Conserved Protein E5N93_RS13055 ENOG4105D9N nucleoside E5N93_RS13060 ENOG4108KMM Diguanylate cyclase E5N93_RS13075 ENOG4105HZG regulatoR E5N93_RS13080 ENOG4105GXM Putative transcription regulator (DUF1323) E5N93_RS13110 ENOG4105CN8 Transcriptional regulator E5N93_RS13120 ENOG4105EAA nucleoside E5N93_RS13125 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) E5N93_RS13130 ENOG4108NFH Sugar hydrolase E5N93_RS13135 ENOG4108M0I Transcriptional regulator E5N93_RS13140 ENOG4105DHU Bile acid E5N93_RS13145 ENOG4105VRT cytoplasmic protein E5N93_RS13150 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) E5N93_RS13160 ENOG4105EXN Sulfate transport protein CysZ E5N93_RS13165 ENOG4105C6T cysteine synthase E5N93_RS13175 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E5N93_RS13180 ENOG4105C5Y PTS System E5N93_RS13190 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) E5N93_RS13195 ENOG4105CSW GntR family transcriptional regulator E5N93_RS13200 ENOG41089BK Glutamine amido-transferase E5N93_RS13205 ENOG4105M0Y E5N93_RS13215 ENOG4105C6T cysteine synthase E5N93_RS13220 ENOG4108IJ6 ABC transporter E5N93_RS13225 ENOG4105ECW sulfate abc transporter E5N93_RS13230 ENOG4108I5D sulfate abc transporter E5N93_RS13235 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein E5N93_RS13240 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr E5N93_RS13245 ENOG4108RS6 transposase E5N93_RS13250 ENOG4105EZR dyp-type peroxidase family protein E5N93_RS13255 ENOG4105E7K (LipO)protein E5N93_RS13260 ENOG4105QZU Inner membrane protein YfeZ E5N93_RS13265 ENOG4108R6G acetyltransferase E5N93_RS13270 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase E5N93_RS13285 ENOG4107H8F E5N93_RS13290 ENOG4108K3Z AraC family transcriptional regulator E5N93_RS13295 ENOG4108X49 Ethanolamine utilization protein EutK E5N93_RS13300 ENOG4106D67 ethanolamine utilization protein E5N93_RS13310 ENOG4105CPD ethanolamine ammonia-lyase E5N93_RS13315 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase E5N93_RS13320 ENOG4105ENY Ethanolamine utilization protein eutH E5N93_RS13325 ENOG4105C0A alcohol dehydrogenase E5N93_RS13330 ENOG4107YMV ethanolamine utilization protein E5N93_RS13335 ENOG4108EKI Dehydrogenase E5N93_RS13340 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E5N93_RS13345 ENOG4105KNY Microcompartments protein E5N93_RS13350 ENOG4108IJ2 phosphate acetyltransferase E5N93_RS13355 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase E5N93_RS13360 ENOG4105NDK ethanolamine utilization protein E5N93_RS13365 ENOG4106S4J ethanolamine utilization protein EutP E5N93_RS13370 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place E5N93_RS13375 ENOG4105C6K Malic enzyme E5N93_RS13380 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E5N93_RS13385 ENOG4105CV1 Transketolase (EC 2.2.1.1) E5N93_RS13395 ENOG4108PVD exported protein E5N93_RS13400 ENOG4107VIJ nudix hydrolase E5N93_RS13405 ENOG4107QK9 Beta-lactamase E5N93_RS13410 ENOG4105BZ8 glutamate synthase E5N93_RS13415 ENOG4105BZU Histidine kinase E5N93_RS13420 ENOG4105BZS acriflavin resistance protein E5N93_RS13430 ENOG4105KUZ arsenate reductase E5N93_RS13435 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) E5N93_RS13445 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) E5N93_RS13450 ENOG4105CGZ zinc metallopeptidase E5N93_RS13460 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E5N93_RS13470 ENOG4105RH4 Glycine cleavage system transcriptional repressor E5N93_RS13475 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E5N93_RS13480 ENOG4105BZW Glycerate kinase E5N93_RS13485 ENOG4105C02 permease E5N93_RS13490 ENOG4105ERG peptidase m48, ste24p E5N93_RS13495 ENOG4105K89 arsenate reductase E5N93_RS13505 ENOG4105C2W permease E5N93_RS13510 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) E5N93_RS13525 ENOG4108V3E phosphoribosylglycinamide formyltransferase E5N93_RS13530 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) E5N93_RS13535 ENOG4105C9X ppx gppa phosphatase E5N93_RS13540 ENOG4105BZU Histidine kinase E5N93_RS13550 ENOG41062G3 Protein of unknown function (DUF2633) E5N93_RS13580 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E5N93_RS13585 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E5N93_RS13620 ENOG4105VPD cellular component movement E5N93_RS13630 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E5N93_RS13635 ENOG4105N21 Membrane E5N93_RS13655 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs E5N93_RS13675 ENOG4105QAX Iron-sulfur E5N93_RS13680 ENOG4107QY8 reductase E5N93_RS13685 ENOG4108JQB penicillin-binding protein 1C E5N93_RS13690 ENOG4105DN3 alpha-2-macroglobulin domain protein E5N93_RS13695 ENOG4105KHC sulfurtransferase E5N93_RS13705 ENOG4105YYA enhanced serine sensitivity protein SseB E5N93_RS13715 ENOG4105WVQ Fe-S assembly protein IscX E5N93_RS13720 ENOG4108ZIT Ferredoxin, 2FE-2S E5N93_RS13725 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB E5N93_RS13730 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) E5N93_RS13735 ENOG4108Z4V iron-sulfur cluster assembly E5N93_RS13740 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E5N93_RS13755 ENOG4105CVS RNA methyltransferase TrmH family, group 1 E5N93_RS13760 ENOG4105ECY inositol monophosphatase E5N93_RS13765 ENOG4107XM9 (LipO)protein E5N93_RS13770 ENOG4105D5B Sulfite reductase, subunit A E5N93_RS13775 ENOG4107SHJ sulfite reductase subunit b E5N93_RS13780 ENOG410810Y Sulfite reductase E5N93_RS13785 ENOG4105D7X high-affinity nickel-transporter E5N93_RS13795 ENOG4108MN2 Stationary phase inducible protein CsiE E5N93_RS13800 ENOG4105D8G Major Facilitator superfamily E5N93_RS13810 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E5N93_RS13815 ENOG4108M3R transcriptional activator CadC E5N93_RS13820 ENOG4105D5Q Arginine ornithine antiporter E5N93_RS13825 ENOG4105CXN decarboxylase E5N93_RS13830 ENOG4105DUX Transporter E5N93_RS13840 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5N93_RS13845 ENOG4108SKK alpha helix protein E5N93_RS13850 ENOG4107WP9 Histidine kinase E5N93_RS13855 ENOG4108ETH Formylglycinamide ribotide synthetase E5N93_RS13865 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) E5N93_RS13870 ENOG4108Z6B deaminase E5N93_RS13875 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB E5N93_RS13890 ENOG4106G6Q Transcriptional regulator E5N93_RS13895 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E5N93_RS13905 ENOG4105DND Transcriptional regulator E5N93_RS13910 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E5N93_RS13920 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E5N93_RS13940 ENOG4105C3F Signal peptidase i E5N93_RS13950 ENOG4105WMJ Positive regulator of sigma E, RseC MucC E5N93_RS13980 ENOG4108IYU L-aspartate oxidase E5N93_RS13990 ENOG4105C1J atp-dependent rna helicase E5N93_RS13995 ENOG41090KR LysR family transcriptional Regulator E5N93_RS14005 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) E5N93_RS14015 ENOG4105EIB trna rrna methyltransferase E5N93_RS14020 ENOG4105K63 Thioredoxin E5N93_RS14025 ENOG4106IUH DTW domain containing protein E5N93_RS14030 ENOG4105CD5 CoA-binding domain protein E5N93_RS14035 ENOG4105JIM Phosphatidylserine synthase E5N93_RS14040 ENOG4105T42 (LipO)protein E5N93_RS14045 ENOG4105CSH Transporter E5N93_RS14075 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5N93_RS14080 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E5N93_RS14085 ENOG4105C34 Pseudouridine synthase E5N93_RS14090 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E5N93_RS14095 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA E5N93_RS14105 ENOG4105CQC Prephenate dehydratase E5N93_RS14115 ENOG4105EHE chorismate mutase- prephenate dehydrogenase E5N93_RS14120 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5N93_RS14125 ENOG4108WS1 E5N93_RS14130 ENOG4108KHX Diguanylate cyclase E5N93_RS14135 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) E5N93_RS14155 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E5N93_RS14160 ENOG4106KVJ cytochrome C assembly protein E5N93_RS14165 ENOG4108JU6 CBS domain protein E5N93_RS14185 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E5N93_RS14190 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E5N93_RS14200 ENOG4108Z1B Cyclase dehydrase E5N93_RS14220 ENOG4105BZ1 (ABC) transporter E5N93_RS14235 ENOG4105DFP Integrase E5N93_RS14240 ENOG4105DFP Integrase E5N93_RS14270 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E5N93_RS14285 ENOG4105HVQ Regulatory factor of maltose metabolism E5N93_RS14290 ENOG410787A Pts system, glucitol sorbitol-specific E5N93_RS14300 ENOG4105DZY Pts system, glucitol sorbitol-specific E5N93_RS14315 ENOG4108VA3 3-hexulose-6-phosphate synthase E5N93_RS14320 ENOG41080HJ 6-phospho 3-hexuloisomerase E5N93_RS14330 ENOG4105CI1 PTS System E5N93_RS14355 ENOG4105DFP Integrase E5N93_RS14390 ENOG4105I03 Flagellin E5N93_RS14455 ENOG4108R0M Aminoglycoside E5N93_RS14480 ENOG4105BZU Histidine kinase E5N93_RS14510 ENOG4108VSE mercuric transport protein E5N93_RS14515 ENOG4105W1Y Transcriptional regulator E5N93_RS14540 ENOG4108ZHR arsR family transcriptional regulator E5N93_RS14555 ENOG4105D6U Sodium Glutamate Symporter E5N93_RS14615 ENOG4108BUD transposase E5N93_RS14640 ENOG4105NIV Esterase E5N93_RS14645 ENOG4107RNH Outer membrane receptor FepA E5N93_RS14655 ENOG4105VRE Pentapeptide repeat protein E5N93_RS14660 ENOG4108MJ5 VirK protein E5N93_RS14680 ENOG4105DHQ Histidine kinase E5N93_RS14710 ENOG4105D5U fad dependent oxidoreductase E5N93_RS14715 ENOG4105C26 Dehydrogenase E5N93_RS14720 ENOG4108JPW Aminotransferase E5N93_RS14725 ENOG4105C85 amino acid E5N93_RS14730 ENOG4108PVQ transcriptional regulator E5N93_RS14735 ENOG4109066 lysm domain bon superfamily protein E5N93_RS14745 ENOG4105VPI YqaE family transport protein E5N93_RS14750 ENOG41080HT Transcriptional regulator, arsr family E5N93_RS14755 ENOG4108V62 Rhodanese domain protein E5N93_RS14765 ENOG4108X73 DNA- binding protein E5N93_RS14775 ENOG4108RNS Exports L-alanine (By similarity) E5N93_RS14780 ENOG4108WMJ Protein of unknown function (DUF2002) E5N93_RS14785 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) E5N93_RS14795 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E5N93_RS14805 ENOG4105WAZ (Glutaredoxin-like protein) NrdH E5N93_RS14815 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5N93_RS14820 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5N93_RS14825 ENOG4108IJ7 Glycine betaine E5N93_RS14830 ENOG4108HQS Glycine betaine E5N93_RS14835 ENOG4105GIJ Glycine betaine E5N93_RS14845 ENOG4105NTK Transcriptional repressor Mpra E5N93_RS14850 ENOG4105CW7 secretion protein, HlyD family E5N93_RS14855 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N93_RS14875 ENOG4105W39 Membrane E5N93_RS14880 ENOG4107VXZ Hydrolase E5N93_RS14910 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) E5N93_RS14915 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) E5N93_RS14925 ENOG4105Y3E Modulates RecA activity (By similarity) E5N93_RS14935 ENOG4107TH8 cina domain protein E5N93_RS14945 ENOG4105CVE Lytic murein transglycosylase E5N93_RS14950 ENOG410787A Pts system, glucitol sorbitol-specific E5N93_RS14955 ENOG4105DZY Pts system, glucitol sorbitol-specific E5N93_RS14960 ENOG4105VI0 Pts system, glucitol sorbitol-specific E5N93_RS14965 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase E5N93_RS14970 ENOG4105J92 DNA-binding transcriptional activator GutM E5N93_RS14975 ENOG410804X Transcriptional regulator E5N93_RS14980 ENOG4105C2X Arabinose 5-phosphate isomerase E5N93_RS14990 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center E5N93_RS14995 ENOG4107QZF nitrite reductase NADPH large subunit E5N93_RS15000 ENOG4105C8H hydrogenase maturation protein Hypf E5N93_RS15005 ENOG4108RC0 Electron transport protein E5N93_RS15015 ENOG4108MG9 hydrogenase 3 maturation protease E5N93_RS15020 ENOG4105I6X formate hydrogenlyase maturation E5N93_RS15025 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit E5N93_RS15030 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit E5N93_RS15035 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E5N93_RS15040 ENOG4107TDF Formate hydrogenlyase subunit 4 E5N93_RS15045 ENOG4107R30 NADH dehydrogenase E5N93_RS15050 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) E5N93_RS15055 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA E5N93_RS15060 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E5N93_RS15065 ENOG4107RSS Hydrogenase accessory protein HypB E5N93_RS15070 ENOG41083WG hydrogenase assembly chaperone E5N93_RS15075 ENOG4105CQS hydrogenase expression formation protein HypD E5N93_RS15080 ENOG4105C45 hydrogenase expression formation protein (HypE) E5N93_RS15090 ENOG4105VXR cytoplasmic protein E5N93_RS15100 ENOG4105DIK (ABC) transporter E5N93_RS15105 ENOG4105CC5 ABC transporter E5N93_RS15110 ENOG4105CC5 ABC transporter E5N93_RS15145 ENOG4108RBT type iii secretion E5N93_RS15150 ENOG4106BTR E5N93_RS15155 ENOG4105Y7Q type iii secretion E5N93_RS15160 ENOG4108RC9 Type III secretion system protein E5N93_RS15170 ENOG4108YAB Invasion protein E5N93_RS15180 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear E5N93_RS15205 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC E5N93_RS15215 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE E5N93_RS15225 ENOG4108M6W surface presentation of antigens protein SpaS E5N93_RS15230 ENOG4108TN6 type iii secretion E5N93_RS15235 ENOG4105U07 type iii secretion E5N93_RS15240 ENOG41075IY surface presentation of antigens protein SpaP E5N93_RS15245 ENOG4105T85 surface presentation of antigens protein E5N93_RS15250 ENOG41078G4 surface presentation of E5N93_RS15255 ENOG41077MC Secretory protein (Associated with virulence) E5N93_RS15260 ENOG4108JIR Flagellum-specific ATP synthase E5N93_RS15265 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone E5N93_RS15270 ENOG4108HR8 type iii secretion E5N93_RS15275 ENOG4108N8R Invasion protein E5N93_RS15285 ENOG41090HZ type iii secretion E5N93_RS15330 ENOG4105MEW serine threonine protein phosphatase E5N93_RS15350 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N93_RS15355 ENOG4105JQN Transcriptional regulator E5N93_RS15360 ENOG4105C6Z Gluconate E5N93_RS15365 ENOG4105EXW epimerase dehydratase E5N93_RS15370 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E5N93_RS15380 ENOG4105G63 Type III effector Hrp-dependent E5N93_RS15390 ENOG4105MVE transcriptional regulator E5N93_RS15400 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E5N93_RS15405 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E5N93_RS15410 ENOG4105KZM cytoplasmic protein E5N93_RS15420 ENOG4108K5P (LipO)protein E5N93_RS15440 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) E5N93_RS15445 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) E5N93_RS15455 ENOG4105N0Z inner membrane protein ygbE E5N93_RS15465 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) E5N93_RS15475 ENOG4108MXK alkaline phosphatase isozyme conversion E5N93_RS15480 ENOG4105PWE CRISPR-associated protein cas2 E5N93_RS15485 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) E5N93_RS15495 ENOG4108VWQ crispr-associated protein E5N93_RS15500 ENOG41060M0 Crispr-associated protein, cse4 family E5N93_RS15525 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) E5N93_RS15530 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) E5N93_RS15535 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E5N93_RS15540 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase E5N93_RS15545 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E5N93_RS15550 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E5N93_RS15555 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) E5N93_RS15565 ENOG4105DXN mazG family E5N93_RS15580 ENOG4105X54 addiction module antidote protein E5N93_RS15585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5N93_RS15590 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) E5N93_RS15595 ENOG4105BZU Histidine kinase E5N93_RS15600 ENOG4105BZW Glycerate kinase E5N93_RS15605 ENOG4105EQX glucarate dehydratase E5N93_RS15610 ENOG4105EQX glucarate dehydratase E5N93_RS15615 ENOG4105DJB Major Facilitator Superfamily E5N93_RS15625 ENOG4105QDK Flavodoxin E5N93_RS15630 ENOG4105DR9 pseudouridine synthase E5N93_RS15635 ENOG4105WP7 tRNA pseudouridine synthase C E5N93_RS15650 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) E5N93_RS15655 ENOG4105EWT decarboxylase family E5N93_RS15660 ENOG4105C44 Serine transporter E5N93_RS15665 ENOG4105EJQ L-serine dehydratase E5N93_RS15675 ENOG4105C0A alcohol dehydrogenase E5N93_RS15680 ENOG4107W7X Aldolase E5N93_RS15685 ENOG4105EDR glucose galactose transporter E5N93_RS15695 ENOG4105CMG Carbohydrate kinase E5N93_RS15700 ENOG4105NWF RbsD or FucU transport E5N93_RS15705 ENOG4107EDW L-fucose operon activator E5N93_RS15715 ENOG4105M08 Membrane E5N93_RS15720 ENOG4105ETT transcriptional Regulator, LysR family E5N93_RS15725 ENOG4105M5B (LipO)protein E5N93_RS15730 ENOG4105C9B Cysteine desulfurase E5N93_RS15735 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) E5N93_RS15740 ENOG4105FR1 rard protein E5N93_RS15745 ENOG4105CUZ uba thif-type nad fad binding protein E5N93_RS15750 ENOG4105CA3 membrane-bound lytic murein transglycosylase E5N93_RS15760 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E5N93_RS15765 ENOG4108EKC n-acetylglutamate synthase E5N93_RS15770 ENOG4107QYX exodeoxyribonuclease v alpha E5N93_RS15775 ENOG4107QKA exodeoxyribonuclease V beta E5N93_RS15780 ENOG4107QXK peptidase E5N93_RS15785 ENOG4105DSY exodeoxyribonuclease V, gamma E5N93_RS15790 ENOG4105RVB Prepilin peptidase dependent protein c E5N93_RS15795 ENOG4105SEN Protein of unknown function (DUF2509) E5N93_RS15800 ENOG4105JCS prepilin peptidase dependent protein E5N93_RS15805 ENOG4105IPU prepilin peptidase dependent protein A E5N93_RS15820 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E5N93_RS15835 ENOG4105EE5 Membrane protein terC E5N93_RS15840 ENOG4105SUV lipoprotein YgdR E5N93_RS15845 ENOG4105CPC Aldo Keto reductase E5N93_RS15855 ENOG4105CEY Amp-dependent synthetase and ligase E5N93_RS15865 ENOG41060NJ transcriptional regulator E5N93_RS15875 ENOG4105RQF LysR family Transcriptional regulator E5N93_RS15885 ENOG4107QNK )-transporter E5N93_RS15890 ENOG4105CHR reductase E5N93_RS15895 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) E5N93_RS15900 ENOG4105CHU acetyl-coa acetyltransferase E5N93_RS15905 ENOG4105C5Q Transcriptional regulator E5N93_RS15915 ENOG4108MHD transport protein E5N93_RS15945 ENOG4106P2F Pfam:Pili_assembly_C E5N93_RS15965 ENOG4108T1M outer membrane protein x E5N93_RS15975 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A E5N93_RS15980 ENOG4105VGJ Virulence-associated protein E5N93_RS16000 ENOG4108K5P (LipO)protein E5N93_RS16020 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E5N93_RS16025 ENOG4105T95 Thiol disulfide interChange protein E5N93_RS16030 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5N93_RS16035 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) E5N93_RS16040 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB E5N93_RS16050 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) E5N93_RS16055 ENOG4108UT2 hemolysin iii E5N93_RS16065 ENOG4105CS2 ec 3.2.1.21 E5N93_RS16095 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E5N93_RS16100 ENOG4105D0A hydroxylase E5N93_RS16105 ENOG4107RAQ aminopeptidase E5N93_RS16125 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E5N93_RS16130 ENOG4108JQ1 Dehydrogenase E5N93_RS16145 ENOG4105MPN Membrane E5N93_RS16155 ENOG4105D64 Mechanosensitive ion channel E5N93_RS16160 ENOG4105D2N Aldolase E5N93_RS16165 ENOG4105BZA Phosphoglycerate kinase E5N93_RS16190 ENOG4108JJB ABC transporter E5N93_RS16195 ENOG4108JJB ABC transporter E5N93_RS16200 ENOG4105CV1 Transketolase (EC 2.2.1.1) E5N93_RS16205 ENOG4108K0D peptidase, M48 E5N93_RS16215 ENOG4108MXF Alpha Beta Hydrolase E5N93_RS16220 ENOG4108R66 Conserved Protein E5N93_RS16225 ENOG4105DG4 malate L-lactate dehydrogenase E5N93_RS16230 ENOG4105CPQ Dehydrogenase E5N93_RS16235 ENOG4105DEI Mannitol dehydrogenase E5N93_RS16245 ENOG4107YCY Transcriptional regulator E5N93_RS16255 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) E5N93_RS16275 ENOG4107QNK )-transporter E5N93_RS16285 ENOG4105RWS endonuclease I E5N93_RS16290 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E5N93_RS16295 ENOG4105D7Z glutathione synthase E5N93_RS16315 ENOG4105CZX twitching motility protein E5N93_RS16320 ENOG4105DFA alanine racemase domain protein E5N93_RS16325 ENOG4108VIA integral membrane protein E5N93_RS16330 ENOG4105VZ9 UPF0235 protein E5N93_RS16340 ENOG4105CSA Coproporphyrinogen iii oxidase E5N93_RS16345 ENOG4106MH3 alpha helix chain E5N93_RS16350 ENOG4105HDK L-asparaginase E5N93_RS16355 ENOG4105K33 Periplasmic Protein E5N93_RS16360 ENOG41090ED Protein with unknown function (DUF469) E5N93_RS16365 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) E5N93_RS16370 ENOG4105CEN a g-specific adenine glycosylase E5N93_RS16375 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) E5N93_RS16385 ENOG4105EAA nucleoside E5N93_RS16390 ENOG4105CXN decarboxylase E5N93_RS16395 ENOG4108UQV Membrane E5N93_RS16415 ENOG41088T4 Helicase IV E5N93_RS16425 ENOG4105GR3 Histidine kinase E5N93_RS16430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5N93_RS16435 ENOG4108PG2 copper resistance E5N93_RS16440 ENOG4105JDN Copper resistance protein E5N93_RS16445 ENOG4105VR0 copper resistance E5N93_RS16450 ENOG4105E3B Multicopper oxidase E5N93_RS16460 ENOG4105DR5 peptidase E5N93_RS16490 ENOG410624V efflux system protein E5N93_RS16755 ENOG4108UUM single-stranded DNA-binding protein E5N93_RS16770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E5N93_RS16815 ENOG4105CDU Replicative dna helicase E5N93_RS16835 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase E5N93_RS16840 ENOG4105CYC Transferase E5N93_RS16845 ENOG4105DJG MaoC domain protein dehydratase E5N93_RS16850 ENOG4105CI0 Citrate lyase E5N93_RS16860 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E5N93_RS16870 ENOG4108UAJ Transcriptional regulator E5N93_RS16880 ENOG4105CUB amino acid E5N93_RS16890 ENOG4105CJP fad dependent oxidoreductase E5N93_RS16895 ENOG4105C26 Dehydrogenase E5N93_RS16920 ENOG4105DPW Major facilitator superfamily MFS_1 E5N93_RS16930 ENOG4105DEI Mannitol dehydrogenase E5N93_RS16945 ENOG4106032 Glutathionylspermidine synthase E5N93_RS16950 ENOG4105CYM Glutathione S-transferase E5N93_RS16955 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein E5N93_RS16960 ENOG4105S10 periplasmic binding protein E5N93_RS16965 ENOG41082MF Hydrogenase assembly chaperone hypC hupF E5N93_RS16970 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E5N93_RS16975 ENOG4108WGS hydrogenase 2-specific chaperone E5N93_RS16980 ENOG4108USZ hydrogenase E5N93_RS16985 ENOG4105DPX Hydrogenase, large subunit E5N93_RS16990 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit E5N93_RS16995 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N93_RS17000 ENOG4105E3S small subunit E5N93_RS17005 ENOG410900S Protein of unknown function (DUF2623) E5N93_RS17010 ENOG4105C8Q Methyl-accepting chemotaxis E5N93_RS17035 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E5N93_RS17040 ENOG4108ZZF transport protein (ExbD) E5N93_RS17045 ENOG4105CWK Biopolymer transport protein, ExbB E5N93_RS17050 ENOG4105C28 cystathionine E5N93_RS17055 ENOG4108K81 inner membrane protein YghB E5N93_RS17060 ENOG4105CF7 AraC family transcriptional regulator E5N93_RS17065 ENOG4108I6A alcohol dehydrogenase E5N93_RS17070 ENOG4105CV8 reductase E5N93_RS17075 ENOG4107QPK )-transporter E5N93_RS17095 ENOG4105CCT upf0313 protein E5N93_RS17100 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E5N93_RS17110 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E5N93_RS17115 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) E5N93_RS17120 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase E5N93_RS17125 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5N93_RS17130 ENOG4105F4I Transcriptional regulator E5N93_RS17135 ENOG4105H4F exported protein E5N93_RS17140 ENOG4105XJC Two component transcriptional regulator (Winged helix family E5N93_RS17145 ENOG4105DHQ Histidine kinase E5N93_RS17150 ENOG4105NF4 modulator of drug activity E5N93_RS17155 ENOG4105VRH Antibiotic biosynthesis monooxygenase E5N93_RS17160 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5N93_RS17165 ENOG4105IPS esterase E5N93_RS17170 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E5N93_RS17175 ENOG4108SX3 cytoplasmic protein E5N93_RS17180 ENOG41087AY ADP-Ribose pyrophosphatase E5N93_RS17190 ENOG4105F1G UPF0441 protein E5N93_RS17195 ENOG4106032 Glutathionylspermidine synthase E5N93_RS17200 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E5N93_RS17210 ENOG4108MR7 Arylsulfotransferase E5N93_RS17220 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) E5N93_RS17230 ENOG4105W0Z cytoplasmic protein E5N93_RS17240 ENOG4105PV3 Inner membrane protein yqiJ E5N93_RS17245 ENOG4107S78 Band 7 protein E5N93_RS17260 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) E5N93_RS17265 ENOG4105I7R Adenylate cyclase E5N93_RS17270 ENOG4106MWK domain protein E5N93_RS17275 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate E5N93_RS17285 ENOG4107ZVW dihydroneopterin aldolase E5N93_RS17310 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E5N93_RS17315 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5N93_RS17320 ENOG4108VCA G U mismatch-specific DNA glycosylase E5N93_RS17330 ENOG4105Q26 Siderophore-interacting protein E5N93_RS17335 ENOG4105NTW Transcriptional regulator E5N93_RS17340 ENOG4105C8Q Methyl-accepting chemotaxis E5N93_RS17345 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor E5N93_RS17355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5N93_RS17365 ENOG4108VKG metal-dependent hydrolase E5N93_RS17370 ENOG4108UB4 uncharacterized protein ygjQ E5N93_RS17375 ENOG4105EE0 oxidoreductase E5N93_RS17380 ENOG4105DU1 integral membrane protein, terc E5N93_RS17390 ENOG4106W5V Membrane E5N93_RS17400 ENOG4105WAY exported protein E5N93_RS17405 ENOG4105NE1 Conserved Protein E5N93_RS17410 ENOG41090KG Inner membrane protein YqjE E5N93_RS17415 ENOG4105YJD E5N93_RS17420 ENOG4108VBZ doxx family E5N93_RS17425 ENOG4105CHF Glutathione S-transferase E5N93_RS17430 ENOG4105KAF membrAne E5N93_RS17435 ENOG4105CWB LysR family transcriptional Regulator E5N93_RS17440 ENOG4108CNN domain protein E5N93_RS17445 ENOG4106D80 Uncharacterized protein YhaL E5N93_RS17455 ENOG4105C44 Serine transporter E5N93_RS17460 ENOG4105EJQ L-serine dehydratase E5N93_RS17465 ENOG4105C6N Formate acetyltransferase E5N93_RS17480 ENOG4105C7B Threonine dehydratase E5N93_RS17485 ENOG410811B TRANSCRIPTIONal E5N93_RS17495 ENOG4105BZW Glycerate kinase E5N93_RS17500 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5N93_RS17510 ENOG4105CTX dehydratase E5N93_RS17515 ENOG4107UEK pfkb domain protein E5N93_RS17520 ENOG4105MVE transcriptional regulator E5N93_RS17525 ENOG4105D2N Aldolase E5N93_RS17530 ENOG4105DE4 1-phosphofructokinase E5N93_RS17535 ENOG4105DM4 PTS System E5N93_RS17540 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E5N93_RS17550 ENOG41082GB PTS system galactitol-specific transporter subunit IIA E5N93_RS17555 ENOG41090UW PTS System E5N93_RS17560 ENOG4105DT3 PTS system, galactitol-specific IIc component E5N93_RS17565 ENOG4107WTH Galactitol-1-phosphate dehydrogenase E5N93_RS17575 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E5N93_RS17595 ENOG4105W4M Transport-associated protein E5N93_RS17600 ENOG4105K4T epimerase E5N93_RS17605 ENOG4107R7Y intracellular protease Pfpi family E5N93_RS17620 ENOG4108YYD acetyltransferase E5N93_RS17640 ENOG4105DEN Luciferase family E5N93_RS17645 ENOG4105F7V ErfK ybiS ycfS ynhG family protein E5N93_RS17655 ENOG4105CIC tryptophan-specific transport protein E5N93_RS17660 ENOG4105C1J atp-dependent rna helicase E5N93_RS17700 ENOG4105CHV Transcription elongation factor NusA E5N93_RS17705 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) E5N93_RS17730 ENOG4105NTZ Preprotein translocase subunit SecG E5N93_RS17740 ENOG4105EEI dihydropteroate synthase E5N93_RS17745 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E5N93_RS17755 ENOG4105HBR Rna-binding protein E5N93_RS17760 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) E5N93_RS17765 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase E5N93_RS17775 ENOG4105QYV Membrane E5N93_RS17780 ENOG4105K46 50S ribosomal protein l27 E5N93_RS17790 ENOG4105EAH synthase E5N93_RS17795 ENOG4105HVQ Regulatory factor of maltose metabolism E5N93_RS17805 ENOG4105VFK BolA family E5N93_RS17810 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane E5N93_RS17815 ENOG4105E3I toluene tolerance E5N93_RS17820 ENOG4107PE3 Mammalian cell entry related domain protein E5N93_RS17825 ENOG4105CY3 ABC transporter, permease E5N93_RS17830 ENOG4105DHJ ABC, transporter E5N93_RS17835 ENOG4105FEU K -dependent Na -Ca exchanger E5N93_RS17840 ENOG4105C2X Arabinose 5-phosphate isomerase E5N93_RS17845 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase E5N93_RS17850 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) E5N93_RS17855 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E5N93_RS17860 ENOG4108IUZ ABC transporter E5N93_RS17865 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5N93_RS17870 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA E5N93_RS17875 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN E5N93_RS17885 ENOG41080Z8 PHOSPHOCARRIER protein E5N93_RS17890 ENOG4108NIH transferase activity, transferring phosphorus-containing groups E5N93_RS17900 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain E5N93_RS17905 ENOG4105BZU Histidine kinase E5N93_RS17910 ENOG4105N5T Radical SAM Protein E5N93_RS17915 ENOG4105CBC glutamate synthase E5N93_RS17920 ENOG4105BZ8 glutamate synthase E5N93_RS17925 ENOG4105DFS Conserved Protein E5N93_RS17930 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin E5N93_RS17935 ENOG4105DZC cytosine deaminase E5N93_RS17940 ENOG4108R66 Conserved Protein E5N93_RS17950 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) E5N93_RS17970 ENOG4105KB2 stringent starvation protein b E5N93_RS17975 ENOG4107MKT Stringent starvation protein a E5N93_RS18000 ENOG4105D6Z AFG1 family ATPase E5N93_RS18005 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III E5N93_RS18010 ENOG4105C0H protease E5N93_RS18020 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E5N93_RS18025 ENOG4105D9Q decarboxylase (Beta subunit) E5N93_RS18030 ENOG4107QSA Oxaloacetate decarboxylase E5N93_RS18040 ENOG4107GFK fumarate E5N93_RS18045 ENOG4106DSS Tartrate dehydratase subunit alpha E5N93_RS18050 ENOG4105C8P )-transporter E5N93_RS18075 ENOG4105RID UPF0379 protein yhcN E5N93_RS18080 ENOG4105RID UPF0379 protein yhcN E5N93_RS18085 ENOG4105UNR (Barnase) inhibitor E5N93_RS18100 ENOG4105ZQC membrane protein AaeX E5N93_RS18105 ENOG4105CR8 Transcriptional regulator E5N93_RS18110 ENOG4105D1U peptidase U62 modulator of DNA gyrase E5N93_RS18115 ENOG4105QD6 exported protein E5N93_RS18120 ENOG4105C03 ribonuclease E5N93_RS18125 ENOG4108Z03 MAF-like protein E5N93_RS18130 ENOG4105VQ7 Rod shape-determining protein MreD E5N93_RS18135 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E5N93_RS18145 ENOG41062P1 Diguanylate cyclase phosphodiesterase E5N93_RS18150 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family E5N93_RS18165 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E5N93_RS18170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E5N93_RS18175 ENOG4105RG0 Membrane E5N93_RS18180 ENOG4108IA2 Sodium pantothenate symporter E5N93_RS18190 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E5N93_RS18200 ENOG4105CEC DNA methylase N-4 N-6 E5N93_RS18205 ENOG41061ME transport protein E5N93_RS18210 ENOG4105BZU Histidine kinase E5N93_RS18215 ENOG4108XG4 DNA-binding transcriptional regulator E5N93_RS18220 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5N93_RS18225 ENOG4105BZS acriflavin resistance protein E5N93_RS18230 ENOG4105XCM membrane LIPOPROTEIN E5N93_RS18265 ENOG4108Z0R Transferase E5N93_RS18270 ENOG4105SG3 Protein of unknown function (DUF1488) E5N93_RS18275 ENOG4105E2X shikimate dehydrogenase E5N93_RS18280 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E5N93_RS18285 ENOG4108WI1 Dna topoisomerase E5N93_RS18295 ENOG4105C79 DNA protecting protein DprA E5N93_RS18310 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E5N93_RS18315 ENOG4105C1A potassium transporter peripheral membrane E5N93_RS18320 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) E5N93_RS18325 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system E5N93_RS18330 ENOG4105W1Y Transcriptional regulator E5N93_RS18335 ENOG4105VTS DnaJ-like, subfamily C E5N93_RS18350 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) E5N93_RS18365 ENOG41067V7 50S ribosomal protein L36 E5N93_RS18370 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E5N93_RS18380 ENOG4105VPB 50S ribosomal protein L30 E5N93_RS18390 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) E5N93_RS18415 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) E5N93_RS18425 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal E5N93_RS18430 ENOG41083MP 50s ribosomal protein l29 E5N93_RS18450 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) E5N93_RS18480 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) E5N93_RS18485 ENOG4108UQY Iron-storage protein E5N93_RS18490 ENOG4105W53 bacterioferritin-associated ferredoxin E5N93_RS18495 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E5N93_RS18505 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) E5N93_RS18515 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) E5N93_RS18520 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) E5N93_RS18530 ENOG4105WWK YheO domain protein E5N93_RS18540 ENOG4108V1T peptidylprolyl cis-trans isomerase E5N93_RS18545 ENOG4105VRX Protein slyX homolog E5N93_RS18550 ENOG4108YZY peptidylprolyl cis-trans isomerase E5N93_RS18555 ENOG4105VKU nucleicacid-binding protein E5N93_RS18570 ENOG4105C5H ABC transporter E5N93_RS18575 ENOG4108K70 Transcriptional regulator E5N93_RS18580 ENOG4105N0V mono-oxygenase ydhR E5N93_RS18585 ENOG4105DNZ Alpha Beta Hydrolase E5N93_RS18595 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) E5N93_RS18600 ENOG4108UKZ OsmC family E5N93_RS18605 ENOG4107RYR Transcriptional regulator, Crp Fnr family E5N93_RS18610 ENOG410613R integral membrane protein, YccS YhfK family E5N93_RS18615 ENOG4105C8Y Acetylornithine aminotransferase E5N93_RS18620 ENOG4105DDQ anthranilate synthase E5N93_RS18625 ENOG4105MZU cell filamentation protein E5N93_RS18630 ENOG4106195 uncharacterized protein yhfG E5N93_RS18635 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E5N93_RS18645 ENOG4107QZF nitrite reductase NADPH large subunit E5N93_RS18650 ENOG4105WZK nitrite reductase NADPH small subunit E5N93_RS18655 ENOG4107V9H nitrite transporter E5N93_RS18660 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E5N93_RS18665 ENOG4107EF2 surface-exposed virulence protein E5N93_RS18670 ENOG4108RS6 transposase E5N93_RS18675 ENOG4105VYH E5N93_RS18680 ENOG4105C31 Tryptophanyl-tRNA synthetase E5N93_RS18685 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E5N93_RS18690 ENOG4105DJV ribulose-phosphate 3-epimerase E5N93_RS18695 ENOG4105DFE Dna adenine methylase E5N93_RS18700 ENOG4105EGB membrane protein DamX E5N93_RS18705 ENOG4105D49 3-dehydroquinate synthase E5N93_RS18715 ENOG4105E4G Type IV pilus E5N93_RS18720 ENOG4105ITY Required for the use of extracellular DNA as a nutrient E5N93_RS18725 ENOG4105XPX DNA utilization protein HofO E5N93_RS18730 ENOG41065NF Fimbrial assembly family protein E5N93_RS18735 ENOG4108U1Q Pilus assembly protein E5N93_RS18740 ENOG4108JQC penicillin-binding protein 1A E5N93_RS18745 ENOG4107RK2 ADP-ribose diphosphatase NudE E5N93_RS18755 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E5N93_RS18760 ENOG4105VEJ Heat shock protein E5N93_RS18765 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) E5N93_RS18770 ENOG4108MAJ Membrane E5N93_RS18780 ENOG4105E0F Histidine kinase E5N93_RS18790 ENOG4108RRZ Transcription elongation factor GreB E5N93_RS18795 ENOG4105BZM domain protein E5N93_RS18800 ENOG4105XFK Ferrous iron transport protein A E5N93_RS18805 ENOG4105CE1 Ferrous iron transport protein b E5N93_RS18815 ENOG4105DNE Transposase E5N93_RS18825 ENOG4105MJ2 Competence protein E5N93_RS18835 ENOG4105C6Z Gluconate E5N93_RS18840 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) E5N93_RS18845 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E5N93_RS18850 ENOG41061ZR Transcriptional regulator E5N93_RS18855 ENOG4105VXN addiction module toxin, RelE StbE family E5N93_RS18865 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP E5N93_RS18870 ENOG4105E0Y RtcB Protein E5N93_RS18885 ENOG4105CYB regulatoR E5N93_RS18890 ENOG4105E98 transcriptional regulator DeoR family E5N93_RS18905 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E5N93_RS18920 ENOG4105DCT glycerol dehydrogenase E5N93_RS18930 ENOG4105C01 Dihydroxy-acid dehydratase E5N93_RS18935 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E5N93_RS18940 ENOG4107HP6 Transcriptional regulator E5N93_RS18945 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E5N93_RS18965 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E5N93_RS18970 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E5N93_RS18975 ENOG41076UM multiple antibiotic resistance (MarC)-related protein E5N93_RS18980 ENOG4105C6Z Gluconate E5N93_RS18985 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E5N93_RS18990 ENOG4105DIQ Transcriptional regulator E5N93_RS18995 ENOG4105C2I pirin domain protein E5N93_RS19000 ENOG4105D9R oxidoreductase E5N93_RS19005 ENOG4105WCN acetyltransferase E5N93_RS19010 ENOG4108RVA ribokinase E5N93_RS19025 ENOG41080QX K07048 phosphotriesterase-related protein E5N93_RS19030 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E5N93_RS19035 ENOG4105WC8 Conserved Protein E5N93_RS19040 ENOG4107T6V glycerophosphoryl diester phosphodiesterase E5N93_RS19045 ENOG4108IJ9 (ABC) transporter E5N93_RS19055 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component E5N93_RS19060 ENOG4105BZ7 extracellular solute-binding protein family 1 E5N93_RS19070 ENOG41060M8 Pfam:PhdYeFM E5N93_RS19075 ENOG4108IV0 ABC, transporter E5N93_RS19080 ENOG4105C0Z ABC transporter E5N93_RS19085 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E5N93_RS19090 ENOG4105C32 Amino acid ABC transporter (Permease) E5N93_RS19095 ENOG4105CP9 extracellular ligand-binding receptor E5N93_RS19100 ENOG4105U59 -acetyltransferase E5N93_RS19110 ENOG4105CP9 extracellular ligand-binding receptor E5N93_RS19120 ENOG4105CRP Part of the ABC transporter FtsEX involved in E5N93_RS19125 ENOG4105CAK Cell division ATP-binding protein ftsE E5N93_RS19130 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E5N93_RS19135 ENOG4106H78 methyltransferase E5N93_RS19140 ENOG4105MG3 Membrane E5N93_RS19150 ENOG4107FS9 Membrane E5N93_RS19160 ENOG4105C8Q Methyl-accepting chemotaxis E5N93_RS19170 ENOG4105EX9 Membrane E5N93_RS19175 ENOG4108W1V Lipoprotein E5N93_RS19185 ENOG4105DSF transport protein E5N93_RS19190 ENOG4107YAK holo-(acyl carrier protein) synthase 2 E5N93_RS19200 ENOG4105CMI transporter E5N93_RS19205 ENOG4105CJ1 ABC, transporter E5N93_RS19210 ENOG4105D0S secretion protein (HlyD E5N93_RS19215 ENOG4105CBX hi0933 family E5N93_RS19220 ENOG4105CJ3 phosphate transporter E5N93_RS19230 ENOG4108M6U Universal stress protein A E5N93_RS19235 ENOG4105DUX Transporter E5N93_RS19240 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) E5N93_RS19245 ENOG4105DGW oligopeptidase A E5N93_RS19250 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E5N93_RS19255 ENOG4105D6S protein involved in catabolism of external DNA E5N93_RS19260 ENOG4105DC8 reductase E5N93_RS19270 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E5N93_RS19275 ENOG4108KPW sugar kinase E5N93_RS19280 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E5N93_RS19285 ENOG4105FDP GntR family transcriptional regulator E5N93_RS19305 ENOG4106S2D Transcriptional regulator E5N93_RS19310 ENOG4105CBN LysR family transcriptional regulator E5N93_RS19315 ENOG4107H3J ribonuclease E5N93_RS19320 ENOG4105CSH Transporter E5N93_RS19325 ENOG41066T0 asmA family E5N93_RS19330 ENOG4105CMB EAL domain-containing protein E5N93_RS19335 ENOG4107SS6 2-dehydro-3-deoxygluconokinase E5N93_RS19340 ENOG4105CS0 peptidase E5N93_RS19350 ENOG4105BZU Histidine kinase E5N93_RS19355 ENOG4105EJG cellulose synthase E5N93_RS19360 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) E5N93_RS19365 ENOG4107EEX Cellulose synthase regulator protein E5N93_RS19370 ENOG4107QZ7 Cellulose synthase catalytic subunit E5N93_RS19375 ENOG4105UTS cellulose synthase operon protein YhjQ E5N93_RS19380 ENOG410661M cytoplasmic protein E5N93_RS19390 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT E5N93_RS19395 ENOG4105D1V cellulose synthase operon protein YhjU E5N93_RS19410 ENOG4105C44 Serine transporter E5N93_RS19415 ENOG4108JQ7 (ABC) transporter E5N93_RS19420 ENOG4105C3U ABC transporter E5N93_RS19425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E5N93_RS19430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E5N93_RS19435 ENOG4105DEF Extracellular solute-binding protein, family 5 E5N93_RS19465 ENOG4105DIJ Phosphoethanolamine transferase E5N93_RS19470 ENOG4106UCC Fimbrial protein E5N93_RS19475 ENOG4105MHR Fimbrial protein E5N93_RS19480 ENOG4105CW0 outer membrane usher protein E5N93_RS19485 ENOG4108VCD Chaperone E5N93_RS19490 ENOG4106EAR Fimbrial protein E5N93_RS19495 ENOG4105EAX Putative lipase E5N93_RS19500 ENOG4108R3E Dna-3-methyladenine glycosylase i E5N93_RS19505 ENOG4105HNP -acetyltransferase E5N93_RS19510 ENOG4107QY8 reductase E5N93_RS19515 ENOG4108ZG0 Ompa motb domain protein E5N93_RS19525 ENOG4106JH6 (LipO)protein E5N93_RS19530 ENOG4105MVF Transcriptional regulator E5N93_RS19560 ENOG4105DQ6 Transposase E5N93_RS19585 ENOG4105MEV Acyl-transferase E5N93_RS19590 ENOG410688U Inner membrane protein yiaB E5N93_RS19595 ENOG4105CMG Carbohydrate kinase E5N93_RS19605 ENOG4105T16 Transcriptional regulator (AraC family) E5N93_RS19610 ENOG4108UR8 BAX protein E5N93_RS19615 ENOG4107T9C Alpha amylase catalytic region E5N93_RS19620 ENOG4105JKW Valine--pyruvate aminotransferase E5N93_RS19625 ENOG4108XIB electron transport protein ysaA E5N93_RS19630 ENOG4105J4Q Transcriptional regulator E5N93_RS19635 ENOG4105DG4 malate L-lactate dehydrogenase E5N93_RS19640 ENOG4108R66 Conserved Protein E5N93_RS19645 ENOG4108M5W E5N93_RS19650 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter E5N93_RS19655 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E5N93_RS19660 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E5N93_RS19665 ENOG4105CMG Carbohydrate kinase E5N93_RS19670 ENOG4105H6Q decarboxylase E5N93_RS19675 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase E5N93_RS19680 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E5N93_RS19695 ENOG4105C26 Dehydrogenase E5N93_RS19700 ENOG41066F8 ROK family E5N93_RS19705 ENOG4105EM7 Selenocysteine-specific translation elongation factor E5N93_RS19715 ENOG4108U78 Glutathione S-transferase E5N93_RS19720 ENOG4105CTS PTS system mannitol-specific E5N93_RS19730 ENOG4105E61 Mannitol repressor protein E5N93_RS19740 ENOG4108YYI Protein of unknown function (DUF2810) E5N93_RS19745 ENOG4108WY4 inner membrane lipoprotein E5N93_RS19750 ENOG4105EUR Domain-Containing protein E5N93_RS19755 ENOG4105DAA L-lactate E5N93_RS19760 ENOG41073TP transcriptional regulator E5N93_RS19770 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E5N93_RS19775 ENOG4105ETE Transcriptional regulator (LacI family E5N93_RS19780 ENOG4105DIA mandelate racemase muconate lactonizing E5N93_RS19785 ENOG4105DJB Major Facilitator Superfamily E5N93_RS19790 ENOG4105D7W serine acetyltransferase E5N93_RS19795 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase E5N93_RS19800 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) E5N93_RS19805 ENOG4105VW4 glutaredoxin 3 E5N93_RS19810 ENOG4107YZP Rhodanese domain protein E5N93_RS19820 ENOG41063SB peptidase E5N93_RS19825 ENOG4105PXI polysaccharide deacetylase E5N93_RS19830 ENOG4105K64 Glycosyl transferase, family 2 E5N93_RS19840 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E5N93_RS19850 ENOG4105XA0 heptosyltransferase ii E5N93_RS19855 ENOG4105D16 lipopolysaccharide heptosyltransferase i E5N93_RS19860 ENOG4108FRV O-antigen ligase E5N93_RS19865 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase E5N93_RS19870 ENOG4108QD8 lipopolysaccharide core biosynthesis protein E5N93_RS19875 ENOG4108PDR lipopolysaccharide core biosynthesis protein E5N93_RS19880 ENOG4105X1N Glycosyl transferase family 8 E5N93_RS19885 ENOG4106AH0 Glycosyl Transferase E5N93_RS19890 ENOG4107XU6 Glycosyl transferase (Group 1 E5N93_RS19905 ENOG4107543 (lipo)polysaccharide E5N93_RS19910 ENOG4107RJ7 Glycosyl transferase (Group 1 E5N93_RS19915 ENOG4105DKP glycosyl transferase, family 9 E5N93_RS19920 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E5N93_RS19925 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) E5N93_RS19950 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E5N93_RS19970 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) E5N93_RS19975 ENOG4105DSJ YicC domain protein E5N93_RS19990 ENOG4105EN6 Membrane E5N93_RS19995 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) E5N93_RS20000 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E5N93_RS20010 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5N93_RS20015 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase E5N93_RS20020 ENOG4105CB5 ATP-dependent DNA helicase recG E5N93_RS20030 ENOG4105D6U Sodium Glutamate Symporter E5N93_RS20035 ENOG4105C2W permease E5N93_RS20040 ENOG4105JV1 AsmA family E5N93_RS20045 ENOG4105CJQ hydrolase, family 31 E5N93_RS20050 ENOG4105CT4 transporter E5N93_RS20070 ENOG4107WZZ SMC domain protein E5N93_RS20095 ENOG4105ISV protein with bipartite regulator domain E5N93_RS20105 ENOG4105FV3 E5N93_RS20110 ENOG4108TC1 Transcriptional regulator E5N93_RS20120 ENOG4105CHJ isochorismatase hydrolase E5N93_RS20135 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic E5N93_RS20145 ENOG4108UZ3 Transporter E5N93_RS20150 ENOG4105DNE Transposase E5N93_RS20165 ENOG4105F3R pts system mannose fructose sorbose family iid E5N93_RS20170 ENOG4105ETZ PTS System E5N93_RS20175 ENOG4105DAS pts system E5N93_RS20190 ENOG4105T8A Uncharacterized protein YicS E5N93_RS20195 ENOG4105CS2 ec 3.2.1.21 E5N93_RS20220 ENOG4105D2N Aldolase E5N93_RS20230 ENOG4105DT3 PTS system, galactitol-specific IIc component E5N93_RS20235 ENOG41090UW PTS System E5N93_RS20250 ENOG4108SAJ Protein of unknown function (DUF1198) E5N93_RS20255 ENOG4105CXY transporter E5N93_RS20260 ENOG4105CXY transporter E5N93_RS20265 ENOG4105BZU Histidine kinase E5N93_RS20270 ENOG4108KX4 response regulator E5N93_RS20280 ENOG4105EDR glucose galactose transporter E5N93_RS20290 ENOG4107FB0 transcriptional regulator DeoR family E5N93_RS20295 ENOG4105M71 acetolactate synthase 1 regulatory subunit E5N93_RS20300 ENOG4105C7K acetolactate synthase E5N93_RS20325 ENOG4105E5M Multidrug resistance protein D E5N93_RS20335 ENOG4105W8I Transcriptional regulator E5N93_RS20345 ENOG4105BZC d-serine deaminase E5N93_RS20350 ENOG4105J13 transcriptional regulator E5N93_RS20355 ENOG4105JP4 Inner membrane protein yidG E5N93_RS20360 ENOG4105VG5 Membrane E5N93_RS20380 ENOG4105R2A (LipO)protein E5N93_RS20385 ENOG4105D99 atp gtp-binding protein E5N93_RS20390 ENOG4105KWW Biogenesis protein E5N93_RS20410 ENOG4105X3C heme exporter protein E5N93_RS20415 ENOG41060IM Heme exporter protein E5N93_RS20420 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E5N93_RS20425 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E5N93_RS20430 ENOG4105CA0 peroxidase E5N93_RS20440 ENOG4108EM1 reductase E5N93_RS20445 ENOG4105CUW cytochrome C-TYPE protein E5N93_RS20450 ENOG4106WF9 DNA-binding transcriptional regulator TorR E5N93_RS20455 ENOG4108SV3 Tmao reductase system periplasmic protein tort E5N93_RS20460 ENOG4105BZU Histidine kinase E5N93_RS20465 ENOG4105DJB Major Facilitator Superfamily E5N93_RS20475 ENOG4108RTU Aldolase E5N93_RS20480 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 E5N93_RS20485 ENOG4105EMF GntR family transcriptional regulator E5N93_RS20490 ENOG410667J hydrolase E5N93_RS20495 ENOG4105DJB Major Facilitator Superfamily E5N93_RS20500 ENOG4105CXK mandelate racemase muconate lactonizing E5N93_RS20510 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5N93_RS20520 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E5N93_RS20530 ENOG4105VG0 50S ribosomal protein l34 E5N93_RS20545 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins E5N93_RS20550 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) E5N93_RS20565 ENOG4107RRE RNA-directed DNA polymerase E5N93_RS20570 ENOG4105CNH Multidrug resistance protein MdtL E5N93_RS20575 ENOG4105G2Y Transcriptional regulator E5N93_RS20580 ENOG4105E8Q phosphopantetheinyl transferase E5N93_RS20585 ENOG4108YYH Nadph-dependent fmn reductase E5N93_RS20590 ENOG4105C7N Xanthine uracil vitamin C permease E5N93_RS20595 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 E5N93_RS20605 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E5N93_RS20610 ENOG4105E2Z phosphate ABC transporter (Permease E5N93_RS20615 ENOG4105C8U phosphate abc transporter E5N93_RS20620 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) E5N93_RS20625 ENOG4105DM4 PTS System E5N93_RS20630 ENOG4105F9E Shikimate 5-dehydrogenase E5N93_RS20635 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) E5N93_RS20640 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E5N93_RS20655 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) E5N93_RS20660 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) E5N93_RS20680 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) E5N93_RS20695 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation E5N93_RS20710 ENOG4105QTB Flavodoxin E5N93_RS20715 ENOG4108VVK transcriptional Regulator, AsnC E5N93_RS20720 ENOG4105CU9 asparagine synthetase A E5N93_RS20730 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) E5N93_RS20745 ENOG4105C2J ABC transporter E5N93_RS20750 ENOG4105CNN ABC, transporter E5N93_RS20755 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E5N93_RS20760 ENOG4108RVA ribokinase E5N93_RS20765 ENOG4105ETE Transcriptional regulator (LacI family E5N93_RS20770 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N93_RS20775 ENOG4107EJG GntR family transcriptional regulator E5N93_RS20820 ENOG4105C0P Mg chelatase subunit ChlI E5N93_RS20835 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit E5N93_RS20840 ENOG4105CM2 brancheD-chain amino acid aminotransferase E5N93_RS20850 ENOG4105C7B Threonine dehydratase E5N93_RS20865 ENOG4105EMY transcriptional regulator E5N93_RS20870 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase E5N93_RS20875 ENOG4105KQ5 peptidylprolyl cis-trans isomerase E5N93_RS20885 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E5N93_RS20890 ENOG4105C4R Atp-dependent dna helicase E5N93_RS20915 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E5N93_RS20920 ENOG4105ESV Glycosyl transferase, family 4 E5N93_RS20925 ENOG4105SFE lipopolysaccharide biosynthesis protein E5N93_RS20930 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E5N93_RS20935 ENOG4108IJ1 Dehydrogenase E5N93_RS20940 ENOG4105C1B dTDP-glucose 4-6-dehydratase E5N93_RS20945 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E5N93_RS20945 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E5N93_RS20950 ENOG4108WJ1 acetyltransferase E5N93_RS20955 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E5N93_RS20960 ENOG4105EGZ biosynthesis protein E5N93_RS20965 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) E5N93_RS20970 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) E5N93_RS20980 ENOG4105C85 amino acid E5N93_RS21005 ENOG410601J HemY protein E5N93_RS21010 ENOG4105ECF c-methyltransferase E5N93_RS21015 ENOG41076E6 Uroporphyrinogen-III Synthase E5N93_RS21025 ENOG4107T0K Adenylate cyclase E5N93_RS21045 ENOG4105XQ6 frataxin-like protein E5N93_RS21060 ENOG4105S7Z (LipO)protein E5N93_RS21070 ENOG4105CT0 Protein of unknown function, DUF484 E5N93_RS21075 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5N93_RS21080 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant E5N93_RS21085 ENOG4105C4R Atp-dependent dna helicase E5N93_RS21090 ENOG4107QUT magnesium and cobalt transport protein CorA E5N93_RS21095 ENOG4105NRM Membrane E5N93_RS21100 ENOG4106WR8 Inner membrane protein YigG E5N93_RS21105 ENOG4105FR1 rard protein E5N93_RS21110 ENOG4108VUY thioesterase Superfamily protein E5N93_RS21115 ENOG4105HDD phospholipase E5N93_RS21120 ENOG4105C9U ATP-dependent DNA helicase RecQ E5N93_RS21125 ENOG4105CCF Lysine exporter protein (Lyse ygga) E5N93_RS21130 ENOG410829K Lysine exporter protein (Lyse ygga) E5N93_RS21135 ENOG4108EUD Lysophospholipase E5N93_RS21140 ENOG4105DQF Hydrolase E5N93_RS21145 ENOG4105EMK carboxylate amino acid amine transporter E5N93_RS21150 ENOG4105DZ2 Transcriptional regulator E5N93_RS21165 ENOG4105C4X radical SAM domain protein E5N93_RS21170 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) E5N93_RS21175 ENOG4107SXA Phosphorylase E5N93_RS21180 ENOG4105CGY Dna recombination protein E5N93_RS21190 ENOG4105JC1 sterol-binding domain protein E5N93_RS21200 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E5N93_RS21205 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) E5N93_RS21210 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) E5N93_RS21215 ENOG4105F8V Hydrolase, tatD family E5N93_RS21220 ENOG4105MDZ Transcriptional activator rfaH E5N93_RS21225 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E5N93_RS21230 ENOG4107QK7 reductase E5N93_RS21235 ENOG4108MR7 Arylsulfotransferase E5N93_RS21240 ENOG4105CHU acetyl-coa acetyltransferase E5N93_RS21245 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) E5N93_RS21255 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E5N93_RS21260 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) E5N93_RS21265 ENOG4108RR8 protoporphyrinogen oxidase E5N93_RS21295 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b E5N93_RS21300 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) E5N93_RS21305 ENOG4105PC1 Conserved Protein E5N93_RS21310 ENOG4105E27 serine threonine protein kinase E5N93_RS21315 ENOG4108Z33 Thiol disulfide Interchange Protein E5N93_RS21320 ENOG4106HNH Acyl-transferase E5N93_RS21325 ENOG4105C2M dna polymerase I E5N93_RS21345 ENOG4105D4P Coproporphyrinogen iii oxidase E5N93_RS21350 ENOG4106FIY E5N93_RS21355 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5N93_RS21360 ENOG4105CUX Signal transduction histidine kinase E5N93_RS21365 ENOG4105C5F glutamine synthetase E5N93_RS21370 ENOG4105CI3 gtp-binding protein typa E5N93_RS21375 ENOG4108K4B hydrolase E5N93_RS21405 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is E5N93_RS21410 ENOG4105CT4 transporter E5N93_RS21415 ENOG4105CT4 transporter E5N93_RS21420 ENOG4105CJQ hydrolase, family 31 E5N93_RS21425 ENOG4107WI4 Aldose-1-epimerase E5N93_RS21430 ENOG4107QKS N-acylglucosamine 2-epimerase E5N93_RS21435 ENOG4105D2M Aldolase E5N93_RS21440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5N93_RS21445 ENOG4108MGF sugar kinase E5N93_RS21450 ENOG4105E98 transcriptional regulator DeoR family E5N93_RS21455 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 E5N93_RS21460 ENOG4107S2Z UPF0761 membrane protein E5N93_RS21470 ENOG4105SUU thioesterase domain E5N93_RS21475 ENOG4108Z3N Transcriptional regulator E5N93_RS21480 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) E5N93_RS21490 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system E5N93_RS21505 ENOG4108MG3 formate dehydrogenase E5N93_RS21510 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N93_RS21525 ENOG4108V87 frv operon regulatory protein E5N93_RS21530 ENOG4108V87 frv operon regulatory protein E5N93_RS21540 ENOG4108UMN azlc family E5N93_RS21555 ENOG4105C0A alcohol dehydrogenase E5N93_RS21565 ENOG4105DKG l-rhamnose isomerase E5N93_RS21570 ENOG4105DET Rhamnulokinase E5N93_RS21590 ENOG4108QGT oligogalacturonate-specific porin E5N93_RS21595 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E5N93_RS21600 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter E5N93_RS21605 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E5N93_RS21610 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5N93_RS21615 ENOG4108RPX mosc domain containing protein E5N93_RS21625 ENOG4105E0F Histidine kinase E5N93_RS21630 ENOG4105E3W Two component transcriptional regulator (Winged helix family E5N93_RS21635 ENOG4105FMW periplasmic E5N93_RS21645 ENOG4105CTQ phosphohexokinase E5N93_RS21650 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E5N93_RS21660 ENOG4105CT4 transporter E5N93_RS21665 ENOG4105D7K pfkb domain protein E5N93_RS21685 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) E5N93_RS21695 ENOG4107RYS Autoinducer-2 (AI-2) kinase E5N93_RS21700 ENOG4105DKT Transcriptional regulator E5N93_RS21705 ENOG4105C2J ABC transporter E5N93_RS21720 ENOG4105D4B ABC, transporter E5N93_RS21730 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound E5N93_RS21745 ENOG4105EBK exported protein E5N93_RS21750 ENOG4108VTS Membrane E5N93_RS21755 ENOG4105DP0 ferredoxin-NADP reductase E5N93_RS21760 ENOG4105CBT Fructose-1,6-bisphosphatase E5N93_RS21770 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E5N93_RS21785 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E5N93_RS21800 ENOG41063M6 Cell Division Protein E5N93_RS21805 ENOG4105ETE Transcriptional regulator (LacI family E5N93_RS21810 ENOG4105C25 Primosomal protein n' E5N93_RS21825 ENOG4108MR7 Arylsulfotransferase E5N93_RS21835 ENOG4105C28 cystathionine E5N93_RS21840 ENOG4105CFH Aspartokinase E5N93_RS21845 ENOG4105D64 Mechanosensitive ion channel E5N93_RS21860 ENOG4105CGH 5'-nucleotidase E5N93_RS21865 ENOG4105SYT Methylenetetrahydrofolate reductase E5N93_RS21875 ENOG4108XC3 NADH ubiquinone oxidoreductase E5N93_RS21880 ENOG4105DCT glycerol dehydrogenase E5N93_RS21890 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E5N93_RS21895 ENOG4105DM4 PTS System E5N93_RS21900 ENOG4108YRF PTS System E5N93_RS21910 ENOG4108AHH pyruvate formate lyase II activase E5N93_RS21915 ENOG4108XCZ PTS System E5N93_RS21920 ENOG4106R3P AraC family transcriptional regulator E5N93_RS21925 ENOG4105DIJ Phosphoethanolamine transferase E5N93_RS21935 ENOG4105CWC Acetylornithine deacetylase E5N93_RS21940 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase E5N93_RS21950 ENOG4105CH7 arginosuccinase E5N93_RS21955 ENOG4105C5Q Transcriptional regulator E5N93_RS21970 ENOG4108Y73 Membrane E5N93_RS22015 ENOG4105D4A Cell wall formation (By similarity) E5N93_RS22020 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase E5N93_RS22055 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E5N93_RS22060 ENOG4105PM1 preprotein translocase subunit SecE E5N93_RS22065 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E5N93_RS22080 ENOG4108VZM 50s ribosomal protein L10 E5N93_RS22085 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) E5N93_RS22090 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E5N93_RS22095 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E5N93_RS22125 ENOG4105D41 biosynthesis protein thiH E5N93_RS22130 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) E5N93_RS22135 ENOG4105WHD thiamine biosynthesis protein ThiS E5N93_RS22140 ENOG4105D06 uba thif-type nad fad binding protein E5N93_RS22145 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) E5N93_RS22160 ENOG4105E09 nadh pyrophosphatase E5N93_RS22175 ENOG4105R2J Conserved Protein E5N93_RS22180 ENOG4105K70 DNA-binding protein E5N93_RS22185 ENOG4108T8B Protein of unknown function (DUF1481) E5N93_RS22195 ENOG4105BZU Histidine kinase E5N93_RS22200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5N93_RS22205 ENOG4105C12 Phosphoribosylglycinamide synthetase E5N93_RS22210 ENOG4105DC1 bifunctional purine biosynthesis protein purh E5N93_RS22240 ENOG4105K5X acetyltransferase E5N93_RS22250 ENOG4107QP3 malate synthase g E5N93_RS22255 ENOG4108I9X Isocitrate lyase E5N93_RS22270 ENOG41069M3 Transcriptional regulator E5N93_RS22275 ENOG4105C3R Methionine synthase E5N93_RS22280 ENOG4105EAM Na Pi-cotransporter E5N93_RS22285 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) E5N93_RS22295 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E5N93_RS22300 ENOG4105FE9 pseudouridine synthase E5N93_RS22305 ENOG4108ZR5 Conserved Protein E5N93_RS22310 ENOG4105C09 Bile acid E5N93_RS22335 ENOG4108X9F tail fiber protein E5N93_RS22360 ENOG4105CKK Glycosyl transferase, family 2 E5N93_RS22365 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) E5N93_RS22445 ENOG4105CFH Aspartokinase E5N93_RS22460 ENOG4108MDC (LipO)protein E5N93_RS22465 ENOG4108Q9C Periplasmic Protein E5N93_RS22470 ENOG4105E3R (LipO)protein E5N93_RS22480 ENOG4105EG2 ABC transporter, permease E5N93_RS22485 ENOG4105D56 permease protein E5N93_RS22490 ENOG4107FKK extracellular solute-binding protein family 1 E5N93_RS22500 ENOG4108IJ9 (ABC) transporter E5N93_RS22510 ENOG4107W52 maltose operon periplasmic protein E5N93_RS22530 ENOG41080IJ Diacylglycerol kinase E5N93_RS22535 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) E5N93_RS22540 ENOG4107R73 Mate efflux family protein E5N93_RS22550 ENOG4105VDW Csbd family E5N93_RS22555 ENOG4105MYN Zinc uptake regulation protein E5N93_RS22565 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E5N93_RS22570 ENOG4105P4Z Phage shock protein G E5N93_RS22575 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E5N93_RS22580 ENOG4105CDU Replicative dna helicase E5N93_RS22585 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E5N93_RS22590 ENOG4105CGF Aromatic amino acid aminotransferase E5N93_RS22595 ENOG4105F0S class B acid phosphatase E5N93_RS22600 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme E5N93_RS22605 ENOG4105MSB protein, conserved in bacteria E5N93_RS22620 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E5N93_RS22625 ENOG4108UUM single-stranded DNA-binding protein E5N93_RS22665 ENOG4105PMV Membrane E5N93_RS22670 ENOG4108M8H domain protein E5N93_RS22675 ENOG4108W3Q Transcriptional regulator E5N93_RS22680 ENOG4108Z4X TRANSCRIPTIONal E5N93_RS22690 ENOG4105C7N Xanthine uracil vitamin C permease E5N93_RS22695 ENOG4105EEQ Na H antiporter E5N93_RS22700 ENOG4105CMU LysR family (Transcriptional regulator E5N93_RS22710 ENOG41067MG lrgb family E5N93_RS22720 ENOG41062QD Membrane E5N93_RS22725 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E5N93_RS22730 ENOG4105EAU Plays a role in nitrite reduction (By similarity) E5N93_RS22735 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit E5N93_RS22740 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N93_RS22745 ENOG4105DVI reductase, NrfD E5N93_RS22750 ENOG4108QKW cytochrome c-type biogenesis protein E5N93_RS22755 ENOG4108W0S formate-dependent nitrite reductase complex E5N93_RS22760 ENOG4105CK2 sodium dicarboxylate symporter E5N93_RS22765 ENOG41082ND Uncharacterized protein yjcO E5N93_RS22780 ENOG410870W N-acetyltransferase E5N93_RS22785 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase E5N93_RS22790 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E5N93_RS22795 ENOG4105CSH Transporter E5N93_RS22805 ENOG4105ECM Sensor protein basS pmrB E5N93_RS22810 ENOG4105XJC Two component transcriptional regulator (Winged helix family E5N93_RS22815 ENOG4105DIJ Phosphoethanolamine transferase E5N93_RS22820 ENOG4105D5Q Arginine ornithine antiporter E5N93_RS22825 ENOG4106ZGR Transcriptional regulator E5N93_RS22830 ENOG4105CXN decarboxylase E5N93_RS22835 ENOG4108K2B transcriptional regulator E5N93_RS22840 ENOG4105F8D glycoside hydrolase family 4 E5N93_RS22845 ENOG4105CT4 transporter E5N93_RS22850 ENOG4107GFK fumarate E5N93_RS22855 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E5N93_RS22865 ENOG4108MRH transcriptional regulatory protein E5N93_RS22870 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E5N93_RS22875 ENOG4107QY8 reductase E5N93_RS22880 ENOG4105QAX Iron-sulfur E5N93_RS22885 ENOG4107KGK dmso reductase anchor subunit E5N93_RS22890 ENOG4108NEM leader-binding protein dmsD E5N93_RS22900 ENOG4108ZK4 sdia-regulated domain-containing protein E5N93_RS22915 ENOG41068CG regulatoR E5N93_RS22940 ENOG4105SBG acid phosphatase E5N93_RS22965 ENOG4108SIC Transcriptional regulator E5N93_RS22970 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E5N93_RS22980 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E5N93_RS22985 ENOG4108IJ0 Aspartate ammonia-lyase E5N93_RS22990 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 E5N93_RS22995 ENOG4105DVH amino acid E5N93_RS23010 ENOG4108ZVF (LipO)protein E5N93_RS23015 ENOG4105MTB Uncharacterized protein YjeJ E5N93_RS23020 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E5N93_RS23025 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E5N93_RS23035 ENOG4106BSU Entericidin B E5N93_RS23045 ENOG4105KPY Small multidrug resistance protein E5N93_RS23055 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) E5N93_RS23065 ENOG4105E33 succinate dehydrogenase E5N93_RS23070 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E5N93_RS23080 ENOG4107SC7 Inner membrane transporter yjeM E5N93_RS23090 ENOG4105EGS Mechanosensitive ion channel E5N93_RS23105 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) E5N93_RS23110 ENOG4106TNF Periplasmic binding protein E5N93_RS23130 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E5N93_RS23135 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E5N93_RS23140 ENOG4105K8N protein family UPF0079, ATPase E5N93_RS23145 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E5N93_RS23150 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E5N93_RS23160 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E5N93_RS23165 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E5N93_RS23170 ENOG4107QJR hflk protein E5N93_RS23175 ENOG4105EPW hflc protein E5N93_RS23195 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E5N93_RS23200 ENOG4105C2N RNA methyltransferase TrmH family group 3 E5N93_RS23205 ENOG4105FUX Conserved Protein E5N93_RS23220 ENOG4107VNS Protein of unknown function (DUF2491) E5N93_RS23225 ENOG4105Z6B inner membrane protein yjfl E5N93_RS23230 ENOG4108KXT Conserved Protein E5N93_RS23235 ENOG4106032 Glutathionylspermidine synthase E5N93_RS23240 ENOG4105CSU acyl-Coa dehydrogenase E5N93_RS23245 ENOG4105S17 UPF0379 protein yjfN E5N93_RS23250 ENOG4105WSB biofilm stress and motility protein A E5N93_RS23255 ENOG4108MXZ Esterase E5N93_RS23270 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E5N93_RS23290 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase E5N93_RS23300 ENOG4105KIT UPF0379 protein yjfY E5N93_RS23315 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) E5N93_RS23320 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) E5N93_RS23325 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) E5N93_RS23340 ENOG4105FHY Opacity-associated protein A E5N93_RS23345 ENOG4108V1T peptidylprolyl cis-trans isomerase E5N93_RS23355 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) E5N93_RS23360 ENOG4105DXC membrane E5N93_RS23370 ENOG4108RS6 transposase E5N93_RS23380 ENOG4105KVH Transcriptional regulator E5N93_RS23385 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E5N93_RS23390 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E5N93_RS23395 ENOG4108UUE Transcriptional regulator E5N93_RS23400 ENOG41061GZ Protein of unknown function (DUF1107) E5N93_RS23405 ENOG4105C37 (CBS) domain E5N93_RS23425 ENOG4108ZHD aig2 family E5N93_RS23430 ENOG4105DJB Major Facilitator Superfamily E5N93_RS23435 ENOG41069H0 dihydroorotase EC 3.5.2.3 E5N93_RS23440 ENOG4105F0N pyrophosphate phospho-hydrolase E5N93_RS23450 ENOG4105DFU Cell wall formation (By similarity) E5N93_RS23455 ENOG4105CHC glucokinase (EC 2.7.1.2) E5N93_RS23460 ENOG4107QNK )-transporter E5N93_RS23470 ENOG4107QNK )-transporter E5N93_RS23475 ENOG4105DH8 myo-inositol catabolism E5N93_RS23480 ENOG4105C26 Dehydrogenase E5N93_RS23505 ENOG4108MYR Secreted protein E5N93_RS23510 ENOG4107VG4 Xylose isomerase domain protein TIM barrel E5N93_RS23520 ENOG4105D7K pfkb domain protein E5N93_RS23525 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) E5N93_RS23530 ENOG4105CK5 oxidoreductase E5N93_RS23535 ENOG4105IE8 Alpha-ketoglutarate permease E5N93_RS23545 ENOG4105F0H myo-inositol catabolism protein E5N93_RS23555 ENOG4105CMS peptidase U62, modulator of DNA gyrase E5N93_RS23560 ENOG4108XVM Cytochrome b(562) E5N93_RS23590 ENOG41069H0 dihydroorotase EC 3.5.2.3 E5N93_RS23605 ENOG4105EMD TRANSCRIPTIONal E5N93_RS23615 ENOG4105K4U addiction module toxin, RelE StbE family E5N93_RS23620 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E5N93_RS23625 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E5N93_RS23630 ENOG4105CG3 alpha amylase, catalytic region E5N93_RS23640 ENOG4105D4X repressor E5N93_RS23660 ENOG4105KME endoribonuclease L-psp E5N93_RS23675 ENOG41077AM PyrBI operon attenuator E5N93_RS23685 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) E5N93_RS23690 ENOG4105CSX c4-dicarboxylate anaerobic carrier E5N93_RS23695 ENOG4105DBV ornithine carbamoyltransferase E5N93_RS23700 ENOG4105C5B carbamate kinase E5N93_RS23705 ENOG4105CEU Arginine dihydrolase E5N93_RS23710 ENOG4105XEP YhcH YjgK YiaL family protein E5N93_RS23715 ENOG4105DBV ornithine carbamoyltransferase E5N93_RS23720 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) E5N93_RS23725 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E5N93_RS23735 ENOG4108MJ3 acetyltransferase E5N93_RS23740 ENOG4108M3P Membrane E5N93_RS23745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E5N93_RS23750 ENOG4105MYG DNA polymerase iii, chi subunit E5N93_RS23760 ENOG4108M8S permease YjgP YjgQ family protein E5N93_RS23765 ENOG4108K5H permease YjgP YjgQ family protein E5N93_RS23770 ENOG4105K2J Transcriptional regulator E5N93_RS23775 ENOG4105C6Z Gluconate E5N93_RS23780 ENOG4105CHR reductase E5N93_RS23785 ENOG4105CPQ Dehydrogenase E5N93_RS23790 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E5N93_RS23795 ENOG4105DQ4 alcohol dehydrogenase E5N93_RS23835 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E5N93_RS23865 ENOG4105CDY transcriptional regulatory protein E5N93_RS23870 ENOG4105DTA methyltransferase E5N93_RS23880 ENOG4105KZM cytoplasmic protein E5N93_RS23905 ENOG4105C6F GntR Family Transcriptional Regulator E5N93_RS23925 ENOG4107YNJ LysR family Transcriptional regulator E5N93_RS23930 ENOG4105DYB Isoaspartyl dipeptidase E5N93_RS23935 ENOG4108P2H Inner membrane protein YjiG E5N93_RS23940 ENOG41074DU domain protein E5N93_RS23945 ENOG4105CBP Major Facilitator E5N93_RS23950 ENOG4106BRA Membrane E5N93_RS23955 ENOG41083G8 Multidrug resistance protein MdtM E5N93_RS23960 ENOG4105DNE Transposase E5N93_RS23965 ENOG4105C26 Dehydrogenase E5N93_RS23990 ENOG4107XZC Restriction modification system DNA (Specificity E5N93_RS23995 ENOG4105CVR type I restriction-modification system E5N93_RS24000 ENOG4107SCJ type I restriction enzyme EcoKI subunit R E5N93_RS24005 ENOG4106H3A restriction E5N93_RS24020 ENOG4105CKI cobalamin synthesis protein E5N93_RS24025 ENOG4105VCD cytoplasmic protein E5N93_RS24030 ENOG4105D22 carbon starvation protein E5N93_RS24035 ENOG4105C8Q Methyl-accepting chemotaxis E5N93_RS24050 ENOG4108IQ3 PTS system E5N93_RS24055 ENOG4105ETZ PTS System E5N93_RS24060 ENOG4105F3R pts system mannose fructose sorbose family iid E5N93_RS24065 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E5N93_RS24070 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E5N93_RS24080 ENOG4105RI1 glycoprotein receptor E5N93_RS24085 ENOG4106CVF DNA replication protein E5N93_RS24100 ENOG4105DWK Membrane E5N93_RS24105 ENOG4108N8T regulatoR E5N93_RS24110 ENOG4108T94 DNA-binding transcriptional activator BglJ E5N93_RS24115 ENOG4108UIN ybak prolyl-trna synthetase associated region E5N93_RS24120 ENOG4108819 ferric iron reductase E5N93_RS24125 ENOG4105BZU Histidine kinase E5N93_RS24130 ENOG4105YBH Protein of unknown function (DUF1435) E5N93_RS24155 ENOG4108WPU DNA polymerase III subunit psi E5N93_RS24160 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E5N93_RS24165 ENOG4105PAD Hydrolase E5N93_RS24175 ENOG4105K3G Periplasmic Protein E5N93_RS24185 ENOG4108NRW Phospholipase, patatin family E5N93_RS24190 ENOG4105EYA deoxyribonuclease E5N93_RS24195 ENOG41076CZ activating enzyme E5N93_RS24200 ENOG4105G0K glycine radical enzyme YjjI family E5N93_RS24230 ENOG4105E6S usher protein( E5N93_RS24235 ENOG4108S1B Periplasmic chaperone protein E5N93_RS24240 ENOG4105UMR response to DNA damage stimulus E5N93_RS24255 ENOG41062Z9 Membrane E5N93_RS24260 ENOG4105EAC phosphoserine phosphatase E5N93_RS24265 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E5N93_RS24270 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase E5N93_RS24275 ENOG4105C5H ABC transporter E5N93_RS24280 ENOG4107SC1 transglycosylase E5N93_RS24290 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E5N93_RS24300 ENOG4105UEI Transcriptional Regulator AraC Family E5N93_RS24305 ENOG4108RH0 Crea protein E5N93_RS24310 ENOG4105E3W Two component transcriptional regulator (Winged helix family E5N93_RS24315 ENOG4105EB3 Histidine kinase E5N93_RS24320 ENOG4105CT7 inner membrane cred family protein E5N93_RS24335 ENOG4105CW0 outer membrane usher protein E5N93_RS24340 ENOG4108VCD Chaperone E5N93_RS24350 ENOG4108PNB DNA-binding transcriptional regulator E5N93_RS24360 ENOG41065U4 response regulator E5N93_RS24365 ENOG410759A E5N93_RS24370 ENOG4106FVC RNA methyltransferase