locus-tag	class	description
HFS76_RS00030	COG0561	phosphatase activity
HFS76_RS00050	COG2198	Histidine kinase
HFS76_RS00050	COG0784	Response regulator, receiver
HFS76_RS00050	COG2205	protein histidine kinase activity
HFS76_RS00055	COG1879	ABC-type sugar transport system periplasmic component
HFS76_RS00060	COG0745	RESPONSE REGULATOR receiver
HFS76_RS00065	COG3005	denitrification pathway
HFS76_RS00080	COG1858	cytochrome C peroxidase
HFS76_RS00090	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS76_RS00095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS76_RS00100	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS76_RS00110	COG1138	Cytochrome C-type biogenesis protein
HFS76_RS00115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFS76_RS00120	COG3088	subunit of a heme lyase
HFS76_RS00120	COG4235	cytochrome complex assembly
HFS76_RS00125	COG0823	Involved in the tonB-independent uptake of proteins
HFS76_RS00130	COG5645	(Lipo)protein
HFS76_RS00150	COG2149	membrane
HFS76_RS00160	COG0641	radical SAM
HFS76_RS00170	COG2610	gluconate transmembrane transporter activity
HFS76_RS00175	COG0583	DNA-binding transcription factor activity
HFS76_RS00185	COG2814	Major facilitator Superfamily
HFS76_RS00210	COG0028	Belongs to the TPP enzyme family
HFS76_RS00215	COG0440	acetolactate synthase activity
HFS76_RS00220	COG1349	DNA-binding transcription factor activity
HFS76_RS00230	COG0738	Major facilitator superfamily
HFS76_RS00265	COG2188	Transcriptional regulator
HFS76_RS00270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS00270	COG3711	transcriptional antiterminator
HFS76_RS00275	COG3414	Phosphotransferase system galactitol-specific IIB component
HFS76_RS00280	COG3775	system Galactitol-specific IIC component
HFS76_RS00315	COG2723	6-phospho-beta-galactosidase activity
HFS76_RS00335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS00335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS76_RS00340	COG3715	PTS system
HFS76_RS00345	COG3716	PTS system mannose fructose sorbose family IID component
HFS76_RS00360	COG5464	transposase or invertase
HFS76_RS00390	COG1335	isochorismatase
HFS76_RS00415	COG2771	luxR family
HFS76_RS00430	COG3121	Chaperone
HFS76_RS00435	COG3188	usher protein
HFS76_RS00445	COG3539	Fimbrial protein
HFS76_RS00455	COG3539	Fimbrial protein
HFS76_RS00470	COG2211	Major facilitator Superfamily
HFS76_RS00475	COG1501	Belongs to the glycosyl hydrolase 31 family
HFS76_RS00480	COG2982	Protein involved in outer membrane biogenesis
HFS76_RS00485	COG2233	PERMEase
HFS76_RS00490	COG0786	glutamate:sodium symporter activity
HFS76_RS00500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFS76_RS00505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFS76_RS00510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFS76_RS00530	COG2860	membrane
HFS76_RS00540	COG0583	DNA-binding transcription factor activity
HFS76_RS00545	COG1561	YicC-like family, N-terminal region
HFS76_RS00570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFS76_RS00600	COG1519	Transferase
HFS76_RS00605	COG0859	PFAM glycosyl transferase family 9
HFS76_RS00610	COG0438	transferase activity, transferring glycosyl groups
HFS76_RS00685	COG1216	Glycosyl transferase, family 2
HFS76_RS00690	COG2861	carbohydrate metabolic process
HFS76_RS00695	COG4942	peptidase
HFS76_RS00705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFS76_RS00710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HFS76_RS00730	COG2271	Major facilitator Superfamily
HFS76_RS00740	COG1609	Transcriptional regulator
HFS76_RS00745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFS76_RS00755	COG2186	Transcriptional regulator
HFS76_RS00785	COG3722	fumarate hydratase activity
HFS76_RS00795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS00795	COG2213	PTS system mannitol-specific
HFS76_RS00805	COG1566	PFAM secretion protein HlyD family protein
HFS76_RS00810	COG0625	glutathione transferase activity
HFS76_RS00820	COG3276	selenocysteine insertion sequence binding
HFS76_RS00825	COG1940	carbohydrate kinase activity
HFS76_RS00830	COG1012	belongs to the aldehyde dehydrogenase family
HFS76_RS00845	COG0235	Class ii aldolase
HFS76_RS00850	COG3623	hexulose-6-phosphate isomerase
HFS76_RS00855	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HFS76_RS00860	COG1070	Carbohydrate kinase
HFS76_RS00865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFS76_RS00870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HFS76_RS00875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HFS76_RS00885	COG2731	YhcH YjgK YiaL family protein
HFS76_RS00895	COG1414	Transcriptional regulator
HFS76_RS00900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS76_RS00905	COG3977	Valine--pyruvate aminotransferase
HFS76_RS00910	COG0366	Alpha amylase catalytic
HFS76_RS00915	COG2992	FlgJ-related protein
HFS76_RS00920	COG1609	Transcriptional regulator
HFS76_RS00920	COG2207	Transcriptional regulator
HFS76_RS00930	COG1070	Carbohydrate kinase
HFS76_RS00935	COG4682	membrane
HFS76_RS00940	COG3274	enterobacterial common antigen metabolic process
HFS76_RS00960	COG2801	Transposase and inactivated derivatives
HFS76_RS00985	COG1278	Cold shock
HFS76_RS00990	COG2944	sequence-specific DNA binding
HFS76_RS01005	COG2885	chlorophyll binding
HFS76_RS01010	COG0243	molybdopterin cofactor binding
HFS76_RS01015	COG0456	acetyltransferase
HFS76_RS01020	COG2818	Glycosylase
HFS76_RS01025	COG5571	outer membrane autotransporter
HFS76_RS01075	COG1609	Transcriptional regulator
HFS76_RS01090	COG0747	negative chemotaxis
HFS76_RS01095	COG0601	transmembrane transport
HFS76_RS01100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFS76_RS01105	COG0444	Belongs to the ABC transporter superfamily
HFS76_RS01110	COG4608	Belongs to the ABC transporter superfamily
HFS76_RS01115	COG0814	amino acid
HFS76_RS01155	COG1215	transferase activity, transferring glycosyl groups
HFS76_RS01175	COG2200	EAL domain
HFS76_RS01175	COG2199	diguanylate cyclase activity
HFS76_RS01190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS01195	COG2200	EAL domain
HFS76_RS01200	COG2982	Protein involved in outer membrane biogenesis
HFS76_RS01205	COG0477	Major facilitator Superfamily
HFS76_RS01210	COG1295	ribonuclease BN
HFS76_RS01215	COG0583	DNA-binding transcription factor activity
HFS76_RS01220	COG2197	response regulator
HFS76_RS01240	COG2188	Transcriptional regulator
HFS76_RS01245	COG2222	sugar isomerase
HFS76_RS01250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS01255	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HFS76_RS01265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFS76_RS01270	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HFS76_RS01310	COG0306	phosphate transporter
HFS76_RS01315	COG2081	HI0933 family
HFS76_RS01320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS76_RS01325	COG1129	ABC transporter
HFS76_RS01325	COG0842	Transport permease protein
HFS76_RS01330	COG0842	Transport permease protein
HFS76_RS01340	COG2091	lysine biosynthetic process via aminoadipic acid
HFS76_RS01345	COG0628	permease
HFS76_RS01360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HFS76_RS01380	COG3714	YhhN family
HFS76_RS01390	COG3776	membrane
HFS76_RS01395	COG0742	ribosomal rna small subunit methyltransferase
HFS76_RS01400	COG0552	protein localization to endoplasmic reticulum
HFS76_RS01405	COG2884	Cell division ATP-binding protein ftsE
HFS76_RS01410	COG2177	Part of the ABC transporter FtsEX involved in
HFS76_RS01480	COG0584	glycerophosphoryl diester phosphodiesterase
HFS76_RS01490	COG0405	Gamma-glutamyltransferase
HFS76_RS01495	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HFS76_RS01510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS01515	COG1247	-acetyltransferase
HFS76_RS01520	COG0673	inositol 2-dehydrogenase activity
HFS76_RS01525	COG1741	Belongs to the pirin family
HFS76_RS01530	COG1609	Transcriptional regulator
HFS76_RS01535	COG3265	gluconokinase activity
HFS76_RS01540	COG2610	gluconate transmembrane transporter activity
HFS76_RS01575	COG0058	SHG alpha-glucan phosphorylase activity
HFS76_RS01580	COG1414	Transcriptional regulator
HFS76_RS01585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFS76_RS01590	COG0129	dihydroxy-acid dehydratase activity
HFS76_RS01600	COG0371	Dehydrogenase
HFS76_RS01615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HFS76_RS01630	COG1349	DNA-binding transcription factor activity
HFS76_RS01635	COG4650	regulator
HFS76_RS01645	COG1690	Belongs to the RtcB family
HFS76_RS01665	COG0058	SHG alpha-glucan phosphorylase activity
HFS76_RS01670	COG1640	4-alpha-glucanotransferase
HFS76_RS01675	COG2610	gluconate transmembrane transporter activity
HFS76_RS01695	COG5464	transposase or invertase
HFS76_RS01710	COG1918	ferrous iron import across plasma membrane
HFS76_RS01715	COG2183	response to ionizing radiation
HFS76_RS01720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFS76_RS01740	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HFS76_RS01755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HFS76_RS01760	COG1011	Hydrolase
HFS76_RS01770	COG0494	nUDIX hydrolase
HFS76_RS01775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HFS76_RS01780	COG4972	Pilus assembly protein
HFS76_RS01785	COG3166	PFAM Fimbrial assembly family protein
HFS76_RS01800	COG4796	Type ii and iii secretion system protein
HFS76_RS01815	COG3266	domain, Protein
HFS76_RS01820	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HFS76_RS01825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFS76_RS01870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFS76_RS01905	COG1289	transmembrane transporter activity
HFS76_RS01915	COG1765	OsmC-like protein
HFS76_RS01920	COG3954	Phosphoribulokinase
HFS76_RS01930	COG0429	hydrolase of the alpha beta-hydrolase fold
HFS76_RS01945	COG0488	(ABC) transporter
HFS76_RS01960	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HFS76_RS01965	COG1047	Peptidyl-prolyl cis-trans
HFS76_RS01975	COG0545	Peptidyl-prolyl cis-trans isomerase
HFS76_RS01980	COG2964	Protein conserved in bacteria
HFS76_RS02035	COG0051	transcription antitermination factor activity, RNA binding
HFS76_RS02060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HFS76_RS02140	COG0201	protein transport
HFS76_RS02180	COG0789	Transcriptional regulator
HFS76_RS02185	COG3036	rescue of stalled ribosome
HFS76_RS02215	COG0758	DNA mediated transformation
HFS76_RS02225	COG0551	DNA topoisomerase type I activity
HFS76_RS02245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFS76_RS02290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFS76_RS02295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS76_RS02300	COG1309	transcriptional regulator
HFS76_RS02315	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HFS76_RS02335	COG4145	pantothenate transmembrane transporter activity
HFS76_RS02340	COG3924	membrane
HFS76_RS02345	COG0439	Biotin carboxylase
HFS76_RS02350	COG0511	ligase activity, forming carbon-carbon bonds
HFS76_RS02365	COG0604	alcohol dehydrogenase
HFS76_RS02370	COG2199	diguanylate cyclase activity
HFS76_RS02370	COG2200	EAL domain
HFS76_RS02375	COG1077	Cell shape determining protein MreB Mrl
HFS76_RS02380	COG1792	Involved in formation and maintenance of cell shape
HFS76_RS02385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HFS76_RS02400	COG3164	Protein of unknown function
HFS76_RS02405	COG0312	modulator of DNA gyrase
HFS76_RS02410	COG0583	DNA-binding transcription factor activity
HFS76_RS02430	COG2732	(Barnase) inhibitor
HFS76_RS02455	COG2188	Transcriptional regulator
HFS76_RS02465	COG0471	metal ion transport
HFS76_RS02470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS76_RS02475	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS76_RS02485	COG5016	pyruvate
HFS76_RS02485	COG0511	ligase activity, forming carbon-carbon bonds
HFS76_RS02490	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HFS76_RS02505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFS76_RS02510	COG3105	Protein conserved in bacteria
HFS76_RS02515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HFS76_RS02535	COG0625	glutathione transferase activity
HFS76_RS02540	COG2969	positive regulation of protein catabolic process
HFS76_RS02570	COG2731	YhcH YjgK YiaL family protein
HFS76_RS02575	COG0402	S-adenosylhomocysteine deaminase activity
HFS76_RS02580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFS76_RS02585	COG4804	nuclease activity
HFS76_RS02590	COG0493	'glutamate synthase
HFS76_RS02595	COG0070	glutamate synthase
HFS76_RS02595	COG0069	glutamate synthase activity
HFS76_RS02595	COG0067	glutamate synthase
HFS76_RS02600	COG1242	4 iron, 4 sulfur cluster binding
HFS76_RS02605	COG0784	Response regulator, receiver
HFS76_RS02605	COG2198	Histidine kinase
HFS76_RS02605	COG5002	protein histidine kinase activity
HFS76_RS02610	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HFS76_RS02620	COG0515	serine threonine protein kinase
HFS76_RS02625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS02650	COG1137	ATPase activity
HFS76_RS02655	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HFS76_RS02660	COG3117	lipopolysaccharide transmembrane transporter activity
HFS76_RS02665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HFS76_RS02675	COG0530	calcium, potassium:sodium antiporter activity
HFS76_RS02680	COG1127	ABC transporter
HFS76_RS02685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFS76_RS02690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFS76_RS02695	COG2854	intermembrane phospholipid transfer
HFS76_RS02700	COG3113	response to antibiotic
HFS76_RS02705	COG5007	Belongs to the BolA IbaG family
HFS76_RS02715	COG3423	Transcriptional regulator
HFS76_RS02720	COG0142	geranyltranstransferase activity
HFS76_RS02735	COG0697	spore germination
HFS76_RS02745	COG2027	D-alanyl-D-alanine carboxypeptidase
HFS76_RS02755	COG1534	Rna-binding protein
HFS76_RS02770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFS76_RS02780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HFS76_RS02850	COG0513	Belongs to the DEAD box helicase family
HFS76_RS02855	COG0814	amino acid
HFS76_RS02865	COG3034	peptidoglycan biosynthetic process
HFS76_RS02870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFS76_RS02875	COG0826	peptidase U32
HFS76_RS02880	COG0826	peptidase U32
HFS76_RS02885	COG3154	lipid carrier protein
HFS76_RS02890	COG3153	acetyltransferase
HFS76_RS02905	COG0693	protein deglycase activity
HFS76_RS02910	COG0702	epimerase
HFS76_RS02915	COG2823	Periplasmic or secreted lipoprotein
HFS76_RS02930	COG3107	peptidoglycan biosynthetic process
HFS76_RS02935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HFS76_RS02945	COG1063	alcohol dehydrogenase
HFS76_RS02950	COG3775	system Galactitol-specific IIC component
HFS76_RS02955	COG3414	Phosphotransferase system galactitol-specific IIB component
HFS76_RS02960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS02975	COG2721	sulfolactate sulfo-lyase activity
HFS76_RS02985	COG2084	Dehydrogenase
HFS76_RS02990	COG1929	Belongs to the glycerate kinase type-1 family
HFS76_RS03005	COG0583	DNA-binding transcription factor activity
HFS76_RS03025	COG1882	Formate acetyltransferase
HFS76_RS03030	COG1760	l-serine dehydratase
HFS76_RS03035	COG0814	amino acid
HFS76_RS03050	COG1741	Belongs to the pirin family
HFS76_RS03055	COG0583	DNA-binding transcription factor activity
HFS76_RS03060	COG3152	Membrane
HFS76_RS03065	COG0435	Glutathione S-transferase
HFS76_RS03070	COG2259	Doxx family
HFS76_RS03080	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HFS76_RS03085	COG4575	ribosome binding
HFS76_RS03090	COG1422	Protein of unknown function (DUF1090)
HFS76_RS03100	COG0586	Pfam SNARE associated Golgi protein
HFS76_RS03115	COG0673	inositol 2-dehydrogenase activity
HFS76_RS03120	COG2949	membrane
HFS76_RS03125	COG1451	nucleotide metabolic process
HFS76_RS03135	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFS76_RS03135	COG1902	pentaerythritol trinitrate reductase activity
HFS76_RS03145	COG0840	transmembrane signaling receptor activity
HFS76_RS03150	COG0840	transmembrane signaling receptor activity
HFS76_RS03155	COG1695	Transcriptional regulator
HFS76_RS03160	COG2375	cellular response to nickel ion
HFS76_RS03165	COG4974	Belongs to the 'phage' integrase family
HFS76_RS03210	COG2176	DNA-directed DNA polymerase activity
HFS76_RS03210	COG5002	protein histidine kinase activity
HFS76_RS03240	COG4695	Portal protein
HFS76_RS03335	COG5301	cellulose 1,4-beta-cellobiosidase activity
HFS76_RS03385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HFS76_RS03410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HFS76_RS03425	COG4991	sh3 domain protein
HFS76_RS03430	COG3025	triphosphatase activity
HFS76_RS03450	COG2268	Band 7 protein
HFS76_RS03455	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFS76_RS03500	COG3384	dioxygenase
HFS76_RS03505	COG0754	glutathionylspermidine amidase activity
HFS76_RS03520	COG0494	nUDIX hydrolase
HFS76_RS03525	COG3151	Protein conserved in bacteria
HFS76_RS03530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFS76_RS03535	COG3150	esterase
HFS76_RS03545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HFS76_RS03550	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFS76_RS03555	COG0642	Histidine kinase
HFS76_RS03565	COG3111	PFAM Bacterial OB fold (BOF) protein
HFS76_RS03570	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HFS76_RS03625	COG4238	major outer membrane lipoprotein
HFS76_RS03640	COG0471	metal ion transport
HFS76_RS03650	COG1979	alcohol dehydrogenase
HFS76_RS03655	COG2207	Transcriptional regulator
HFS76_RS03675	COG0848	biopolymer transport protein
HFS76_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS03705	COG0840	transmembrane signaling receptor activity
HFS76_RS03715	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HFS76_RS03720	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS03725	COG5557	Pfam Polysulphide reductase, NrfD
HFS76_RS03730	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HFS76_RS03735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HFS76_RS03740	COG1773	rubredoxin
HFS76_RS03750	COG0298	carbon dioxide binding
HFS76_RS03755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFS76_RS03765	COG0625	glutathione transferase activity
HFS76_RS03770	COG0754	glutathionylspermidine amidase activity
HFS76_RS03785	COG0246	Mannitol dehydrogenase
HFS76_RS03795	COG2271	Major facilitator Superfamily
HFS76_RS03820	COG1012	belongs to the aldehyde dehydrogenase family
HFS76_RS03825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFS76_RS03835	COG0531	amino acid
HFS76_RS03910	COG1811	Na channel or pump
HFS76_RS03915	COG1982	Orn Lys Arg decarboxylase major
HFS76_RS03920	COG2211	Major facilitator Superfamily
HFS76_RS03945	COG3171	Protein conserved in bacteria
HFS76_RS03955	COG0252	asparaginase activity
HFS76_RS03965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFS76_RS03980	COG0762	integral membrane protein
HFS76_RS03985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HFS76_RS03990	COG2805	Type II/IV secretion system protein
HFS76_RS04015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFS76_RS04020	COG2356	endonuclease I
HFS76_RS04030	COG2814	Major facilitator Superfamily
HFS76_RS04055	COG1166	arginine decarboxylase activity
HFS76_RS04065	COG2186	Transcriptional regulator
HFS76_RS04075	COG0246	Mannitol dehydrogenase
HFS76_RS04080	COG1063	alcohol dehydrogenase
HFS76_RS04085	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HFS76_RS04090	COG2731	YhcH YjgK YiaL family protein
HFS76_RS04095	COG2267	carboxylic ester hydrolase activity
HFS76_RS04105	COG0501	Belongs to the peptidase M48B family
HFS76_RS04110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFS76_RS04115	COG1122	ATPase activity
HFS76_RS04120	COG1122	ATPase activity
HFS76_RS04150	COG0191	fructose-bisphosphate aldolase activity
HFS76_RS04155	COG0668	transmembrane transport
HFS76_RS04165	COG2968	Membrane
HFS76_RS04180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFS76_RS04185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFS76_RS04205	COG0006	proline dipeptidase activity
HFS76_RS04210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFS76_RS04215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFS76_RS04240	COG2723	6-phospho-beta-galactosidase activity
HFS76_RS04250	COG1272	protein, Hemolysin III
HFS76_RS04305	COG4942	peptidase
HFS76_RS04340	COG3188	usher protein
HFS76_RS04375	COG0814	amino acid
HFS76_RS04390	COG0183	Belongs to the thiolase family
HFS76_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS04405	COG2814	Major facilitator Superfamily
HFS76_RS04410	COG1794	racemase activity, acting on amino acids and derivatives
HFS76_RS04415	COG0583	DNA-binding transcription factor activity
HFS76_RS04425	COG1609	Transcriptional regulator
HFS76_RS04445	COG0667	Aldo Keto reductase
HFS76_RS04455	COG0861	Integral membrane protein TerC family
HFS76_RS04485	COG2165	general secretion pathway protein
HFS76_RS04490	COG4795	General secretion pathway protein
HFS76_RS04500	COG4967	type IV pilus modification protein PilV
HFS76_RS04505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HFS76_RS04515	COG1074	ATP-dependent DNA helicase activity
HFS76_RS04520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFS76_RS04530	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFS76_RS04545	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HFS76_RS04550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HFS76_RS04555	COG2962	Rard protein
HFS76_RS04560	COG2166	iron-sulfur cluster assembly
HFS76_RS04565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFS76_RS04575	COG0583	DNA-binding transcription factor activity
HFS76_RS04580	COG2363	Small membrane protein
HFS76_RS04590	COG1349	DNA-binding transcription factor activity
HFS76_RS04610	COG0738	Major facilitator superfamily
HFS76_RS04615	COG0235	Class ii aldolase
HFS76_RS04620	COG1454	alcohol dehydrogenase
HFS76_RS04630	COG1760	l-serine dehydratase
HFS76_RS04635	COG0814	amino acid
HFS76_RS04640	COG1611	Belongs to the LOG family
HFS76_RS04655	COG3098	single-species biofilm formation
HFS76_RS04665	COG0716	FMN binding
HFS76_RS04670	COG2271	Major facilitator Superfamily
HFS76_RS04675	COG4948	Mandelate Racemase Muconate Lactonizing
HFS76_RS04680	COG4948	Mandelate Racemase Muconate Lactonizing
HFS76_RS04685	COG1929	Belongs to the glycerate kinase type-1 family
HFS76_RS04690	COG3850	Histidine kinase
HFS76_RS04690	COG3437	response regulator, receiver
HFS76_RS04690	COG2205	protein histidine kinase activity
HFS76_RS04690	COG4999	Histidine kinase
HFS76_RS04700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFS76_RS04735	COG3539	Fimbrial protein
HFS76_RS04740	COG3121	Chaperone
HFS76_RS04745	COG3188	usher protein
HFS76_RS04750	COG3539	Fimbrial protein
HFS76_RS04755	COG3956	TIGRFAM MazG family protein
HFS76_RS04770	COG0602	queuosine metabolic process
HFS76_RS04775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HFS76_RS04775	COG0321	lipoyl(octanoyl) transferase activity
HFS76_RS04780	COG0720	synthase
HFS76_RS04785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFS76_RS04805	COG1203	CRISPR-associated helicase, Cas3
HFS76_RS04820	COG1857	crispr-associated protein
HFS76_RS04835	COG1518	maintenance of DNA repeat elements
HFS76_RS04840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFS76_RS04845	COG2234	aminopeptidase activity
HFS76_RS04915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HFS76_RS04920	COG0163	prenyltransferase activity
HFS76_RS04930	COG1349	DNA-binding transcription factor activity
HFS76_RS04935	COG2084	Dehydrogenase
HFS76_RS04945	COG0235	Class ii aldolase
HFS76_RS04950	COG3622	Belongs to the hyi family
HFS76_RS04955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFS76_RS04960	COG2610	gluconate transmembrane transporter activity
HFS76_RS04970	COG0477	Major facilitator Superfamily
HFS76_RS05045	COG2207	Transcriptional regulator
HFS76_RS05135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFS76_RS05220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFS76_RS05225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFS76_RS05230	COG1121	(ABC) transporter
HFS76_RS05250	COG0309	Hydrogenase expression formation protein (HypE)
HFS76_RS05255	COG0409	Hydrogenase expression formation protein
HFS76_RS05260	COG0298	carbon dioxide binding
HFS76_RS05265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HFS76_RS05280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS76_RS05285	COG0651	ATP synthesis coupled electron transport
HFS76_RS05290	COG0650	Formate hydrogenlyase subunit 4
HFS76_RS05295	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HFS76_RS05295	COG3261	NADH dehydrogenase
HFS76_RS05300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFS76_RS05305	COG3260	NADH ubiquinone oxidoreductase 20
HFS76_RS05315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HFS76_RS05325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS76_RS05330	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HFS76_RS05355	COG1349	DNA-binding transcription factor activity
HFS76_RS05360	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS05365	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS05370	COG3731	PTS system glucitol sorbitol-specific IIA component
HFS76_RS05375	COG3732	PTS system glucitol sorbitol-specific
HFS76_RS05380	COG3730	PTS system glucitol sorbitol-specific
HFS76_RS05385	COG2951	lytic endotransglycosylase activity
HFS76_RS05390	COG1546	Belongs to the CinA family
HFS76_RS05410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HFS76_RS05440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFS76_RS05445	COG1238	metal cluster binding
HFS76_RS05465	COG2814	Major facilitator Superfamily
HFS76_RS05470	COG1566	PFAM secretion protein HlyD family protein
HFS76_RS05475	COG1846	Transcriptional regulator
HFS76_RS05480	COG2814	Major facilitator Superfamily
HFS76_RS05520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFS76_RS05530	COG4575	ribosome binding
HFS76_RS05555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFS76_RS05560	COG0640	Transcriptional regulator
HFS76_RS05565	COG0401	homolog of Blt101
HFS76_RS05570	COG1652	LysM domain
HFS76_RS05575	COG1802	Transcriptional regulator
HFS76_RS05580	COG1113	amino acid transport
HFS76_RS05585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFS76_RS05590	COG1012	belongs to the aldehyde dehydrogenase family
HFS76_RS05595	COG0579	oxidoreductase
HFS76_RS05630	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HFS76_RS05640	COG2990	Protein conserved in bacteria
HFS76_RS05660	COG2819	hydrolase of the alpha beta superfamily
HFS76_RS05685	COG0582	viral genome integration into host DNA
HFS76_RS05695	COG4974	Belongs to the 'phage' integrase family
HFS76_RS05730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFS76_RS05770	COG4695	Portal protein
HFS76_RS05860	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HFS76_RS05870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFS76_RS05925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS76_RS05950	COG2867	negative regulation of translational initiation
HFS76_RS05965	COG0497	DNA recombination
HFS76_RS05985	COG4536	flavin adenine dinucleotide binding
HFS76_RS05990	COG4137	Cytochrome C assembly protein
HFS76_RS05995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFS76_RS06020	COG2199	diguanylate cyclase activity
HFS76_RS06035	COG1605	Chorismate mutase
HFS76_RS06035	COG0287	Prephenate dehydrogenase
HFS76_RS06045	COG1605	Chorismate mutase
HFS76_RS06045	COG0077	Prephenate dehydratase
HFS76_RS06055	COG4974	Belongs to the 'phage' integrase family
HFS76_RS06095	COG4695	Portal protein
HFS76_RS06185	COG5301	cellulose 1,4-beta-cellobiosidase activity
HFS76_RS06220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HFS76_RS06225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFS76_RS06240	COG0542	response to heat
HFS76_RS06270	COG0477	Major facilitator Superfamily
HFS76_RS06275	COG5544	Lipoprotein
HFS76_RS06280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFS76_RS06290	COG3148	PFAM DTW domain containing protein
HFS76_RS06295	COG3118	belongs to the thioredoxin family
HFS76_RS06300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFS76_RS06320	COG0583	DNA-binding transcription factor activity
HFS76_RS06325	COG0513	Belongs to the DEAD box helicase family
HFS76_RS06360	COG3086	response to oxidative stress
HFS76_RS06390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HFS76_RS06400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS76_RS06405	COG0583	DNA-binding transcription factor activity
HFS76_RS06410	COG2223	nitrite transmembrane transporter activity
HFS76_RS06415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFS76_RS06420	COG1737	Transcriptional regulator
HFS76_RS06430	COG1263	PTS System
HFS76_RS06430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS76_RS06435	COG0560	Phosphoserine phosphatase
HFS76_RS06455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFS76_RS06455	COG0047	phosphoribosylformylglycinamidine synthase activity
HFS76_RS06460	COG2205	protein histidine kinase activity
HFS76_RS06465	COG3170	Tfp pilus assembly protein FimV
HFS76_RS06470	COG2204	response regulator
HFS76_RS06475	COG0347	Belongs to the P(II) protein family
HFS76_RS06480	COG3104	oligopeptide transport
HFS76_RS06490	COG0531	amino acid
HFS76_RS06495	COG3710	Transcriptional regulator
HFS76_RS06500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFS76_RS06500	COG1017	nitric oxide dioxygenase activity
HFS76_RS06510	COG2814	Major facilitator Superfamily
HFS76_RS06515	COG3711	transcriptional antiterminator
HFS76_RS06525	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HFS76_RS06570	COG0822	iron-sulfur transferase activity
HFS76_RS06590	COG0633	Ferredoxin
HFS76_RS06595	COG2975	iron-sulfur cluster assembly
HFS76_RS06620	COG2897	thiosulfate sulfurtransferase activity
HFS76_RS06625	COG2373	Large extracellular alpha-helical protein
HFS76_RS06630	COG4953	penicillin-binding protein 1C
HFS76_RS06635	COG0243	molybdopterin cofactor binding
HFS76_RS06640	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS06680	COG2976	Protein conserved in bacteria
HFS76_RS06695	COG1645	bacterial-type flagellum-dependent swarming motility
HFS76_RS06730	COG0517	IMP dehydrogenase activity
HFS76_RS06730	COG0516	GMP reductase activity
HFS76_RS06740	COG0582	viral genome integration into host DNA
HFS76_RS06745	COG0653	protein targeting
HFS76_RS06775	COG2200	EAL domain
HFS76_RS06790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFS76_RS06805	COG2233	PERMEase
HFS76_RS06815	COG1393	Belongs to the ArsC family
HFS76_RS06825	COG0628	permease
HFS76_RS06830	COG3835	regulator
HFS76_RS06835	COG2610	gluconate transmembrane transporter activity
HFS76_RS06840	COG1929	Belongs to the glycerate kinase type-1 family
HFS76_RS06845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFS76_RS06850	COG2716	regulation of RNA biosynthetic process
HFS76_RS06860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HFS76_RS06870	COG2321	neutral zinc metallopeptidase
HFS76_RS06890	COG1393	Belongs to the ArsC family
HFS76_RS06900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFS76_RS06905	COG3850	Histidine kinase
HFS76_RS06910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS76_RS06910	COG0493	'glutamate synthase
HFS76_RS06925	COG5342	invasion associated locus B
HFS76_RS06935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFS76_RS07070	COG2837	iron assimilation
HFS76_RS07090	COG4208	sulfate ABC transporter
HFS76_RS07145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS07170	COG3530	Putative quorum-sensing-regulated virulence factor
HFS76_RS07175	COG0385	Bile acid
HFS76_RS07180	COG0583	DNA-binding transcription factor activity
HFS76_RS07190	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HFS76_RS07195	COG2211	Major facilitator Superfamily
HFS76_RS07205	COG0583	DNA-binding transcription factor activity
HFS76_RS07235	COG3415	Transposase
HFS76_RS07240	COG3415	Transposase
HFS76_RS07255	COG2200	EAL domain
HFS76_RS07255	COG2199	diguanylate cyclase activity
HFS76_RS07260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFS76_RS07275	COG0667	Aldo Keto reductase
HFS76_RS07280	COG3961	Belongs to the TPP enzyme family
HFS76_RS07295	COG0436	Aminotransferase
HFS76_RS07305	COG1560	Kdo2-lipid A biosynthetic process
HFS76_RS07345	COG2116	formate transmembrane transporter activity
HFS76_RS07360	COG3691	Protein conserved in bacteria
HFS76_RS07375	COG2062	phosphohistidine phosphatase, SixA
HFS76_RS07400	COG0730	response to heat
HFS76_RS07405	COG3101	peptidyl-lysine hydroxylation
HFS76_RS07420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFS76_RS07465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HFS76_RS07475	COG0586	Pfam SNARE associated Golgi protein
HFS76_RS07485	COG0285	dihydrofolate synthase activity
HFS76_RS07490	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HFS76_RS07495	COG1286	toxin biosynthetic process
HFS76_RS07500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFS76_RS07505	COG3829	transcription factor binding
HFS76_RS07515	COG0531	amino acid
HFS76_RS07520	COG3457	Alanine racemase
HFS76_RS07525	COG0833	amino acid
HFS76_RS07560	COG1090	epimerase
HFS76_RS07565	COG0625	glutathione transferase activity
HFS76_RS07570	COG0625	glutathione transferase activity
HFS76_RS07575	COG0622	Phosphoesterase
HFS76_RS07585	COG1609	Transcriptional regulator
HFS76_RS07590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS07600	COG3037	sugar-specific permease SgaT UlaA
HFS76_RS07605	COG3959	Transketolase, thiamine diphosphate binding domain
HFS76_RS07610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HFS76_RS07615	COG1288	antiporter activity
HFS76_RS07640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFS76_RS07645	COG0471	metal ion transport
HFS76_RS07645	COG0490	domain, Protein
HFS76_RS07655	COG0436	Aminotransferase
HFS76_RS07660	COG0583	DNA-binding transcription factor activity
HFS76_RS07710	COG0839	Belongs to the complex I subunit 6 family
HFS76_RS07720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFS76_RS07725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFS76_RS07740	COG2304	oxidoreductase activity
HFS76_RS07745	COG0784	Response regulator, receiver
HFS76_RS07745	COG0835	chemotaxis
HFS76_RS07755	COG2153	protein acetylation
HFS76_RS07760	COG4575	ribosome binding
HFS76_RS07765	COG1169	isochorismate synthase
HFS76_RS07855	COG1414	Transcriptional regulator
HFS76_RS07865	COG2271	Major facilitator Superfamily
HFS76_RS07880	COG5160	protein modification by small protein removal
HFS76_RS07885	COG0247	lactate metabolic process
HFS76_RS07895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HFS76_RS07900	COG2271	Major facilitator Superfamily
HFS76_RS07905	COG0584	glycerophosphoryl diester phosphodiesterase
HFS76_RS07910	COG0583	DNA-binding transcription factor activity
HFS76_RS07915	COG2814	Major facilitator Superfamily
HFS76_RS07920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFS76_RS07950	COG4948	Mandelate Racemase Muconate Lactonizing
HFS76_RS07970	COG2198	Histidine kinase
HFS76_RS07970	COG0642	Histidine kinase
HFS76_RS07995	COG4615	Cyclic peptide transporter
HFS76_RS08005	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS76_RS08005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS76_RS08010	COG3062	negative regulation of establishment of protein localization
HFS76_RS08020	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS08025	COG0348	domain, Protein
HFS76_RS08030	COG3043	anaerobic respiration
HFS76_RS08035	COG3005	denitrification pathway
HFS76_RS08040	COG4133	protoheme IX ABC transporter activity
HFS76_RS08045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS76_RS08050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS76_RS08055	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS76_RS08065	COG1138	Cytochrome C-type biogenesis protein
HFS76_RS08070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFS76_RS08075	COG3088	subunit of a heme lyase
HFS76_RS08075	COG4235	cytochrome complex assembly
HFS76_RS08080	COG2197	response regulator
HFS76_RS08125	COG1061	Type III restriction enzyme res subunit
HFS76_RS08135	COG2814	Major facilitator Superfamily
HFS76_RS08145	COG4172	Belongs to the ABC transporter superfamily
HFS76_RS08150	COG4239	(ABC) transporter, permease
HFS76_RS08155	COG4174	ABC transporter (Permease)
HFS76_RS08160	COG4166	transmembrane transport
HFS76_RS08165	COG2200	EAL domain
HFS76_RS08170	COG0791	NLP P60 protein
HFS76_RS08175	COG0671	phosphoesterase, PA-phosphatase related
HFS76_RS08180	COG0523	cobalamin synthesis protein
HFS76_RS08215	COG1105	Belongs to the carbohydrate kinase PfkB family
HFS76_RS08220	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFS76_RS08220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFS76_RS08220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFS76_RS08230	COG2855	membrane
HFS76_RS08235	COG0583	DNA-binding transcription factor activity
HFS76_RS08240	COG0833	amino acid
HFS76_RS08245	COG4771	TonB-dependent receptor
HFS76_RS08250	COG2271	Major facilitator Superfamily
HFS76_RS08255	COG0560	Phosphoserine phosphatase
HFS76_RS08260	COG1760	l-serine dehydratase
HFS76_RS08280	COG2311	Membrane
HFS76_RS08310	COG0493	'glutamate synthase
HFS76_RS08320	COG2949	membrane
HFS76_RS08330	COG1346	cytolysis
HFS76_RS08345	COG2271	Major facilitator Superfamily
HFS76_RS08360	COG0625	glutathione transferase activity
HFS76_RS08365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFS76_RS08380	COG1538	Outer membrane efflux protein
HFS76_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS08390	COG0586	Pfam SNARE associated Golgi protein
HFS76_RS08400	COG1686	Belongs to the peptidase S11 family
HFS76_RS08405	COG0277	FAD linked oxidase domain protein
HFS76_RS08415	COG1732	Glycine betaine
HFS76_RS08420	COG1174	glycine betaine transport
HFS76_RS08425	COG1125	glycine betaine transport
HFS76_RS08430	COG1174	glycine betaine transport
HFS76_RS08445	COG3275	phosphorelay sensor kinase activity
HFS76_RS08455	COG4807	Protein conserved in bacteria
HFS76_RS08465	COG4808	Protein conserved in bacteria
HFS76_RS08490	COG3121	Chaperone
HFS76_RS08495	COG3188	usher protein
HFS76_RS08500	COG3539	Fimbrial protein
HFS76_RS08505	COG5455	response to cobalt ion
HFS76_RS08520	COG2188	Transcriptional regulator
HFS76_RS08525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS08530	COG1397	ADP-ribosylglycohydrolase
HFS76_RS08535	COG2211	Major facilitator Superfamily
HFS76_RS08540	COG1830	Aldolase
HFS76_RS08565	COG4974	Belongs to the 'phage' integrase family
HFS76_RS08630	COG4695	Portal protein
HFS76_RS08740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFS76_RS08785	COG0826	peptidase U32
HFS76_RS08870	COG0745	RESPONSE REGULATOR receiver
HFS76_RS08875	COG2205	protein histidine kinase activity
HFS76_RS08905	COG0443	Heat shock 70 kDa protein
HFS76_RS08910	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HFS76_RS08915	COG3447	MASE1 domain protein
HFS76_RS08915	COG5001	Diguanylate cyclase
HFS76_RS08915	COG5002	protein histidine kinase activity
HFS76_RS08930	COG2982	Protein involved in outer membrane biogenesis
HFS76_RS08935	COG1253	flavin adenine dinucleotide binding
HFS76_RS08955	COG0463	Glycosyl transferase, family 2
HFS76_RS08960	COG1045	serine acetyltransferase
HFS76_RS08965	COG0438	transferase activity, transferring glycosyl groups
HFS76_RS08975	COG1216	Glycosyl transferase, family 2
HFS76_RS08980	COG0110	maltose O-acetyltransferase activity
HFS76_RS08985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HFS76_RS08990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFS76_RS08995	COG1051	belongs to the nudix hydrolase family
HFS76_RS09000	COG0297	glycogen (starch) synthase activity
HFS76_RS09015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFS76_RS09020	COG2244	polysaccharide biosynthetic process
HFS76_RS09025	COG2327	Polysaccharide pyruvyl transferase
HFS76_RS09070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFS76_RS09185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFS76_RS09190	COG0583	DNA-binding transcription factor activity
HFS76_RS09200	COG0531	amino acid
HFS76_RS09205	COG2925	Exonuclease
HFS76_RS09245	COG1289	transmembrane transporter activity
HFS76_RS09280	COG4656	Part of a membrane complex involved in electron transport
HFS76_RS09285	COG1454	alcohol dehydrogenase
HFS76_RS09285	COG1012	belongs to the aldehyde dehydrogenase family
HFS76_RS09300	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HFS76_RS09315	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HFS76_RS09445	COG1122	ATPase activity
HFS76_RS09480	COG1982	Orn Lys Arg decarboxylase major
HFS76_RS09490	COG0697	spore germination
HFS76_RS09500	COG0583	DNA-binding transcription factor activity
HFS76_RS09510	COG0640	Transcriptional regulator
HFS76_RS09515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFS76_RS09545	COG0534	Mate efflux family protein
HFS76_RS09570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFS76_RS09640	COG0582	viral genome integration into host DNA
HFS76_RS09760	COG0582	viral genome integration into host DNA
HFS76_RS09820	COG3381	protein complex oligomerization
HFS76_RS09875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFS76_RS09890	COG2943	transferase activity, transferring hexosyl groups
HFS76_RS09895	COG5645	(Lipo)protein
HFS76_RS09910	COG1560	Kdo2-lipid A biosynthetic process
HFS76_RS09925	COG3038	cytochrome b561
HFS76_RS09960	COG2999	glutathione oxidoreductase activity
HFS76_RS09970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFS76_RS10060	COG1530	ribonuclease E activity
HFS76_RS10120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFS76_RS10125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFS76_RS10130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFS76_RS10140	COG0470	DNA polymerase III
HFS76_RS10145	COG0084	hydrolase, TatD family'
HFS76_RS10155	COG4773	Receptor
HFS76_RS10160	COG0537	adenosine 5'-monophosphoramidase activity
HFS76_RS10165	COG5633	Lipoprotein
HFS76_RS10190	COG1252	NADH dehydrogenase
HFS76_RS10195	COG3134	Outer membrane lipoprotein
HFS76_RS10200	COG1309	transcriptional regulator
HFS76_RS10210	COG1388	LysM domain
HFS76_RS10210	COG1376	ErfK ybiS ycfS ynhG family protein
HFS76_RS10215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFS76_RS10220	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFS76_RS10225	COG1136	(ABC) transporter
HFS76_RS10230	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFS76_RS10250	COG1177	transmembrane transport
HFS76_RS10280	COG2850	peptidyl-arginine hydroxylation
HFS76_RS10295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFS76_RS10325	COG0538	isocitrate dehydrogenase activity
HFS76_RS10390	COG0071	Belongs to the small heat shock protein (HSP20) family
HFS76_RS10400	COG3038	cytochrome b561
HFS76_RS10430	COG1124	(ABC) transporter
HFS76_RS10435	COG0668	transmembrane transport
HFS76_RS10450	COG3443	Belongs to the bacterial solute-binding protein 9 family
HFS76_RS10465	COG0789	Transcriptional regulator
HFS76_RS10475	COG1605	Chorismate mutase
HFS76_RS10485	COG3615	Tellurite resistance protein tehB
HFS76_RS10500	COG2261	transglycosylase associated protein
HFS76_RS10510	COG3042	response to heat
HFS76_RS10520	COG3189	MarR family transcriptional regulator
HFS76_RS10525	COG2807	transmembrane transport
HFS76_RS10530	COG2207	Transcriptional regulator
HFS76_RS10545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFS76_RS10550	COG2199	diguanylate cyclase activity
HFS76_RS10565	COG2766	serine protein kinase
HFS76_RS10570	COG3713	MltA-interacting MipA family protein
HFS76_RS10575	COG0641	radical SAM
HFS76_RS10580	COG0656	L-ascorbic acid biosynthetic process
HFS76_RS10600	COG3139	Protein of unknown function (DUF1315)
HFS76_RS10605	COG1335	isochorismatase
HFS76_RS10610	COG0252	asparaginase activity
HFS76_RS10615	COG0616	signal peptide processing
HFS76_RS10620	COG0778	Nitroreductase
HFS76_RS10645	COG0494	nUDIX hydrolase
HFS76_RS10680	COG3678	ATP-independent chaperone mediated protein folding
HFS76_RS10695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFS76_RS10700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFS76_RS10705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFS76_RS10710	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFS76_RS10715	COG2169	Transcriptional regulator
HFS76_RS10715	COG1917	Cupin 2, conserved barrel domain protein
HFS76_RS10720	COG1486	melibiose metabolic process
HFS76_RS10730	COG0753	catalase activity
HFS76_RS10740	COG1823	symporter activity
HFS76_RS10745	COG1988	membrane-bound metal-dependent
HFS76_RS10750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFS76_RS10760	COG3001	Fructosamine kinase
HFS76_RS10770	COG1105	Belongs to the carbohydrate kinase PfkB family
HFS76_RS10775	COG3137	Salt-induced outer membrane protein
HFS76_RS10850	COG0386	Belongs to the glutathione peroxidase family
HFS76_RS10860	COG0791	NLP P60 protein
HFS76_RS10875	COG4256	Hemin uptake protein
HFS76_RS10890	COG0574	Belongs to the PEP-utilizing enzyme family
HFS76_RS10890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFS76_RS10895	COG0318	PFAM AMP-dependent synthetase and ligase
HFS76_RS10900	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HFS76_RS10905	COG0644	oxidoreductase
HFS76_RS10910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFS76_RS10915	COG2086	electron transfer activity
HFS76_RS10920	COG1917	Cupin 2, conserved barrel domain protein
HFS76_RS10920	COG2207	Transcriptional regulator
HFS76_RS10925	COG1960	acyl-CoA dehydrogenase activity
HFS76_RS10930	COG4670	ketone body catabolic process
HFS76_RS10945	COG2271	Major facilitator Superfamily
HFS76_RS10950	COG0738	Major facilitator superfamily
HFS76_RS10965	COG0628	permease
HFS76_RS10970	COG0247	lactate metabolic process
HFS76_RS10970	COG0277	FAD linked oxidase domain protein
HFS76_RS10975	COG2050	protein possibly involved in aromatic compounds catabolism
HFS76_RS10985	COG1823	symporter activity
HFS76_RS10990	COG0316	Belongs to the HesB IscA family
HFS76_RS10995	COG0719	Fe-S assembly protein
HFS76_RS11000	COG0396	ATPase activity
HFS76_RS11005	COG0719	Fe-S assembly protein
HFS76_RS11020	COG1376	ErfK ybiS ycfS ynhG family protein
HFS76_RS11025	COG4238	major outer membrane lipoprotein
HFS76_RS11040	COG0531	amino acid
HFS76_RS11045	COG2267	carboxylic ester hydrolase activity
HFS76_RS11055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS11090	COG3272	Protein of unknown function (DUF1722)
HFS76_RS11095	COG0789	Transcriptional regulator
HFS76_RS11275	COG0307	riboflavin synthase, alpha
HFS76_RS11280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HFS76_RS11285	COG2814	Major facilitator Superfamily
HFS76_RS11290	COG0583	DNA-binding transcription factor activity
HFS76_RS11310	COG0791	NLP P60 protein
HFS76_RS11315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HFS76_RS11330	COG1902	pentaerythritol trinitrate reductase activity
HFS76_RS11335	COG1309	transcriptional regulator
HFS76_RS11340	COG3313	Fe-S protein
HFS76_RS11345	COG4989	oxidoreductase activity
HFS76_RS11360	COG1566	PFAM secretion protein HlyD family protein
HFS76_RS11385	COG3895	Periplasmic Protein
HFS76_RS11405	COG0625	glutathione transferase activity
HFS76_RS11415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFS76_RS11465	COG0673	inositol 2-dehydrogenase activity
HFS76_RS11485	COG5339	Protein conserved in bacteria
HFS76_RS11510	COG2205	protein histidine kinase activity
HFS76_RS11515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HFS76_RS11520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HFS76_RS11525	COG0745	RESPONSE REGULATOR receiver
HFS76_RS11530	COG3136	membrane protein required for alginate biosynthesis
HFS76_RS11535	COG0531	amino acid
HFS76_RS11545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HFS76_RS11550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HFS76_RS11555	COG0628	permease
HFS76_RS11570	COG3591	Belongs to the peptidase S1B family
HFS76_RS11580	COG2814	Major facilitator Superfamily
HFS76_RS11585	COG0583	DNA-binding transcription factor activity
HFS76_RS11590	COG1940	carbohydrate kinase activity
HFS76_RS11630	COG3302	dmso reductase anchor subunit
HFS76_RS11635	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS11640	COG0243	molybdopterin cofactor binding
HFS76_RS11645	COG0243	molybdopterin cofactor binding
HFS76_RS11660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFS76_RS11680	COG1063	alcohol dehydrogenase
HFS76_RS11685	COG0477	Major facilitator Superfamily
HFS76_RS11690	COG0246	Mannitol dehydrogenase
HFS76_RS11700	COG1802	Transcriptional regulator
HFS76_RS11705	COG4221	oxidoreductase activity
HFS76_RS11715	COG3729	General stress protein
HFS76_RS11720	COG1546	Belongs to the CinA family
HFS76_RS11725	COG3111	PFAM Bacterial OB fold (BOF) protein
HFS76_RS11735	COG2814	Major facilitator Superfamily
HFS76_RS11770	COG0583	DNA-binding transcription factor activity
HFS76_RS11775	COG1012	belongs to the aldehyde dehydrogenase family
HFS76_RS11790	COG3781	membrane
HFS76_RS11815	COG1773	rubredoxin
HFS76_RS11840	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HFS76_RS11845	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HFS76_RS11855	COG2186	Transcriptional regulator
HFS76_RS11860	COG1063	alcohol dehydrogenase
HFS76_RS11865	COG2271	Major facilitator Superfamily
HFS76_RS11890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HFS76_RS11895	COG0251	oxidation-reduction process
HFS76_RS11940	COG1609	Transcriptional regulator
HFS76_RS11945	COG1757	Na H antiporter
HFS76_RS11950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HFS76_RS11965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HFS76_RS11980	COG1764	response to oxidative stress
HFS76_RS12000	COG1064	alcohol dehydrogenase
HFS76_RS12005	COG2864	formate dehydrogenase
HFS76_RS12010	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS12050	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HFS76_RS12055	COG1140	nitrate reductase beta subunit
HFS76_RS12060	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HFS76_RS12065	COG2181	nitrate reductase activity
HFS76_RS12100	COG4772	TonB-dependent receptor
HFS76_RS12105	COG1802	Transcriptional regulator
HFS76_RS12110	COG2130	NADP-dependent
HFS76_RS12120	COG3238	Protein conserved in bacteria
HFS76_RS12160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFS76_RS12165	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HFS76_RS12190	COG0826	peptidase U32
HFS76_RS12195	COG1396	sequence-specific DNA binding
HFS76_RS12200	COG3135	benzoate transporter
HFS76_RS12210	COG0500	methyltransferase
HFS76_RS12215	COG1275	C4-dicarboxylate transporter malic acid transport protein
HFS76_RS12220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFS76_RS12225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFS76_RS12235	COG3414	Phosphotransferase system galactitol-specific IIB component
HFS76_RS12240	COG3775	system Galactitol-specific IIC component
HFS76_RS12245	COG0434	BtpA family
HFS76_RS12250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS12255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFS76_RS12260	COG1349	DNA-binding transcription factor activity
HFS76_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS12280	COG2271	Major facilitator Superfamily
HFS76_RS12285	COG1063	alcohol dehydrogenase
HFS76_RS12305	COG2272	Belongs to the type-B carboxylesterase lipase family
HFS76_RS12310	COG5383	Protein conserved in bacteria
HFS76_RS12315	COG0583	DNA-binding transcription factor activity
HFS76_RS12320	COG0840	transmembrane signaling receptor activity
HFS76_RS12355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS76_RS12360	COG0765	amino acid transport
HFS76_RS12370	COG0765	amino acid transport
HFS76_RS12380	COG0500	methyltransferase
HFS76_RS12385	COG3038	cytochrome b561
HFS76_RS12390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HFS76_RS12395	COG1643	Atp-dependent helicase
HFS76_RS12410	COG3784	Protein of unknown function (DUF1318)
HFS76_RS12420	COG2911	Protein conserved in bacteria
HFS76_RS12425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFS76_RS12430	COG3187	Heat shock protein
HFS76_RS12435	COG3042	response to heat
HFS76_RS12445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFS76_RS12445	COG1013	pyruvate-flavodoxin oxidoreductase activity
HFS76_RS12445	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFS76_RS12445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HFS76_RS12455	COG2076	Multidrug Resistance protein
HFS76_RS12475	COG0513	Belongs to the DEAD box helicase family
HFS76_RS12485	COG0840	transmembrane signaling receptor activity
HFS76_RS12490	COG2840	Smr protein MutS2
HFS76_RS12510	COG3182	Iron-regulated membrane protein
HFS76_RS12515	COG0668	transmembrane transport
HFS76_RS12535	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HFS76_RS12570	COG1309	transcriptional regulator
HFS76_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS12580	COG0656	L-ascorbic acid biosynthetic process
HFS76_RS12585	COG0583	DNA-binding transcription factor activity
HFS76_RS12595	COG4166	transmembrane transport
HFS76_RS12600	COG2866	Carboxypeptidase
HFS76_RS12605	COG4948	Mandelate Racemase Muconate Lactonizing
HFS76_RS12625	COG3106	COG3106 Predicted ATPase
HFS76_RS12630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFS76_RS12640	COG1983	PspC domain protein
HFS76_RS12650	COG1842	Phage shock protein A
HFS76_RS12655	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HFS76_RS12710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFS76_RS12710	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFS76_RS12720	COG5001	Diguanylate cyclase
HFS76_RS12730	COG1349	DNA-binding transcription factor activity
HFS76_RS12750	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HFS76_RS12755	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HFS76_RS12760	COG0671	phosphoesterase, PA-phosphatase related
HFS76_RS12800	COG0616	signal peptide processing
HFS76_RS12805	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS12820	COG0009	L-threonylcarbamoyladenylate synthase
HFS76_RS12860	COG3729	General stress protein
HFS76_RS12865	COG3685	Protein conserved in bacteria
HFS76_RS12870	COG3685	Protein conserved in bacteria
HFS76_RS12875	COG3546	catalase activity
HFS76_RS12880	COG3047	cAMP biosynthetic process
HFS76_RS12885	COG0727	PFAM Uncharacterised protein family (UPF0153)
HFS76_RS12910	COG2350	Protein conserved in bacteria
HFS76_RS12930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFS76_RS12960	COG2095	MarC family integral membrane protein
HFS76_RS12965	COG1012	belongs to the aldehyde dehydrogenase family
HFS76_RS12965	COG1454	alcohol dehydrogenase
HFS76_RS12980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFS76_RS12985	COG0745	RESPONSE REGULATOR receiver
HFS76_RS12990	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFS76_RS13000	COG0788	formyltetrahydrofolate deformylase activity
HFS76_RS13045	COG2181	nitrate reductase activity
HFS76_RS13050	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HFS76_RS13055	COG1140	nitrate reductase beta subunit
HFS76_RS13060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HFS76_RS13065	COG2223	nitrite transmembrane transporter activity
HFS76_RS13070	COG3850	Histidine kinase
HFS76_RS13075	COG2197	response regulator
HFS76_RS13080	COG4932	domain protein
HFS76_RS13085	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HFS76_RS13090	COG4572	Cation transport regulator
HFS76_RS13095	COG0387	Pfam Sodium calcium exchanger
HFS76_RS13145	COG0659	secondary active sulfate transmembrane transporter activity
HFS76_RS13160	COG0012	GTP binding
HFS76_RS13175	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HFS76_RS13185	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HFS76_RS13190	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HFS76_RS13195	COG1999	signal sequence binding
HFS76_RS13200	COG1773	rubredoxin
HFS76_RS13205	COG1271	oxidase subunit
HFS76_RS13210	COG1294	oxidase, subunit
HFS76_RS13220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFS76_RS13245	COG1619	proteins homologs of microcin C7 resistance protein MccF
HFS76_RS13265	COG2719	SpoVR family
HFS76_RS13305	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFS76_RS13320	COG2894	cell division
HFS76_RS13330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HFS76_RS13340	COG3065	identical protein binding
HFS76_RS13350	COG1199	ATP-dependent helicase activity
HFS76_RS13355	COG0251	oxidation-reduction process
HFS76_RS13375	COG1760	l-serine dehydratase
HFS76_RS13380	COG2200	EAL domain
HFS76_RS13385	COG1253	flavin adenine dinucleotide binding
HFS76_RS13390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS76_RS13390	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS13395	COG3715	PTS system
HFS76_RS13400	COG3716	PTS system mannose fructose sorbose family IID component
HFS76_RS13415	COG2226	methyltransferase
HFS76_RS13420	COG0768	penicillin binding
HFS76_RS13450	COG1414	Transcriptional regulator
HFS76_RS13455	COG2814	Major facilitator Superfamily
HFS76_RS13475	COG1956	GAF domain-containing protein
HFS76_RS13480	COG2995	paraquat-inducible protein a
HFS76_RS13485	COG3008	intermembrane lipid transfer
HFS76_RS13520	COG5562	phage envelope protein
HFS76_RS13550	COG4680	protein conserved in bacteria
HFS76_RS13555	COG5499	transcription regulator containing HTH domain
HFS76_RS13610	COG1276	copper resistance
HFS76_RS13615	COG2372	response to copper ion
HFS76_RS13625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFS76_RS13630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFS76_RS13635	COG1770	oligopeptidase
HFS76_RS13640	COG2979	Protein of unknown function (DUF533)
HFS76_RS13650	COG3141	response to X-ray
HFS76_RS13660	COG0800	Aldolase
HFS76_RS13665	COG0129	dihydroxy-acid dehydratase activity
HFS76_RS13670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFS76_RS13675	COG1737	Transcriptional regulator
HFS76_RS13685	COG1560	Kdo2-lipid A biosynthetic process
HFS76_RS13690	COG0739	heme binding
HFS76_RS13695	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HFS76_RS13705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFS76_RS13740	COG0494	nUDIX hydrolase
HFS76_RS13750	COG1335	isochorismatase
HFS76_RS13755	COG1801	Protein of unknown function DUF72
HFS76_RS13760	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HFS76_RS13780	COG3102	Protein conserved in bacteria
HFS76_RS13795	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HFS76_RS13900	COG1528	Iron-storage protein
HFS76_RS13915	COG1528	Iron-storage protein
HFS76_RS13925	COG0814	amino acid
HFS76_RS13930	COG3318	Belongs to the UPF0149 family
HFS76_RS13930	COG3012	SEC-C Motif Domain Protein
HFS76_RS13975	COG2197	response regulator
HFS76_RS13990	COG2197	response regulator
HFS76_RS13995	COG1126	abc transporter atp-binding protein
HFS76_RS14000	COG0765	amino acid transport
HFS76_RS14010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS76_RS14070	COG0425	Belongs to the sulfur carrier protein TusA family
HFS76_RS14175	COG5475	Uncharacterized small protein (DUF2158)
HFS76_RS14180	COG2354	Protein conserved in bacteria
HFS76_RS14185	COG0697	spore germination
HFS76_RS14190	COG3727	T/G mismatch-specific endonuclease activity
HFS76_RS14195	COG0270	DNA (cytosine-5-)-methyltransferase activity
HFS76_RS14200	COG1418	mRNA catabolic process
HFS76_RS14210	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HFS76_RS14250	COG3209	COG3209 Rhs family protein
HFS76_RS14335	COG3157	Type VI secretion system effector, Hcp
HFS76_RS14395	COG1702	phosphate starvation-inducible protein PhoH
HFS76_RS14415	COG1309	transcriptional regulator
HFS76_RS14420	COG3729	General stress protein
HFS76_RS14440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFS76_RS14445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFS76_RS14445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFS76_RS14450	COG4232	protein-disulfide reductase activity
HFS76_RS14495	COG3971	2-oxopent-4-enoate hydratase activity
HFS76_RS14505	COG3384	dioxygenase
HFS76_RS14510	COG1012	belongs to the aldehyde dehydrogenase family
HFS76_RS14520	COG1846	Transcriptional regulator
HFS76_RS14525	COG2368	4-hydroxyphenylacetate
HFS76_RS14540	COG0745	RESPONSE REGULATOR receiver
HFS76_RS14545	COG2205	protein histidine kinase activity
HFS76_RS14595	COG0670	Belongs to the BI1 family
HFS76_RS14615	COG1881	PFAM PEBP family protein
HFS76_RS14630	COG1832	CoA-binding protein
HFS76_RS14645	COG0210	DNA helicase
HFS76_RS14650	COG3304	Inner membrane component domain
HFS76_RS14655	COG1289	transmembrane transporter activity
HFS76_RS14660	COG3070	regulator of competence-specific genes
HFS76_RS14680	COG1067	ATP-dependent peptidase activity
HFS76_RS14690	COG3130	regulation of translation
HFS76_RS14695	COG3009	Protein conserved in bacteria
HFS76_RS14700	COG3008	intermembrane lipid transfer
HFS76_RS14700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFS76_RS14705	COG2995	paraquat-inducible protein a
HFS76_RS14710	COG0488	(ABC) transporter
HFS76_RS14720	COG3217	Mosc domain protein beta barrel domain protein
HFS76_RS14720	COG0633	Ferredoxin
HFS76_RS14735	COG0308	aminopeptidase N
HFS76_RS14745	COG1115	amino acid carrier protein
HFS76_RS14755	COG1522	sequence-specific DNA binding
HFS76_RS14765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HFS76_RS14775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFS76_RS14780	COG3108	Peptidase M15
HFS76_RS14785	COG2989	Protein conserved in bacteria
HFS76_RS14795	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HFS76_RS14805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFS76_RS14810	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HFS76_RS14815	COG3173	Aminoglycoside phosphotransferase
HFS76_RS14830	COG3214	Protein conserved in bacteria
HFS76_RS14845	COG2333	competence protein COMEC
HFS76_RS14845	COG0658	competence protein
HFS76_RS14855	COG0539	negative regulation of cytoplasmic translation
HFS76_RS14865	COG0501	Belongs to the peptidase M48B family
HFS76_RS14880	COG2323	membrane
HFS76_RS14885	COG1944	ATP diphosphatase activity
HFS76_RS14890	COG2116	formate transmembrane transporter activity
HFS76_RS14895	COG1882	Formate acetyltransferase
HFS76_RS14905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFS76_RS14910	COG0531	amino acid
HFS76_RS14920	COG3302	dmso reductase anchor subunit
HFS76_RS14925	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS14930	COG0243	molybdopterin cofactor binding
HFS76_RS14940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFS76_RS14960	COG0492	ferredoxin-NADP+ reductase activity
HFS76_RS14965	COG4988	ABC transporter
HFS76_RS14970	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HFS76_RS14990	COG0583	DNA-binding transcription factor activity
HFS76_RS15000	COG1335	isochorismatase
HFS76_RS15035	COG0542	response to heat
HFS76_RS15045	COG1278	Cold shock
HFS76_RS15050	COG0577	efflux transmembrane transporter activity
HFS76_RS15050	COG1136	(ABC) transporter
HFS76_RS15055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS76_RS15060	COG2990	Protein conserved in bacteria
HFS76_RS15065	COG3593	DNA synthesis involved in DNA repair
HFS76_RS15080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFS76_RS15085	COG0028	Belongs to the TPP enzyme family
HFS76_RS15090	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HFS76_RS15095	COG0702	epimerase
HFS76_RS15100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFS76_RS15105	COG3023	N-Acetylmuramoyl-L-alanine amidase
HFS76_RS15120	COG1126	abc transporter atp-binding protein
HFS76_RS15125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS76_RS15130	COG4215	(ABC) transporter
HFS76_RS15135	COG4160	amino acid transport
HFS76_RS15140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS76_RS15170	COG1177	transmembrane transport
HFS76_RS15175	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFS76_RS15180	COG3842	ATPase activity
HFS76_RS15185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HFS76_RS15225	COG3226	Transcriptional regulator
HFS76_RS15230	COG0738	Major facilitator superfamily
HFS76_RS15235	COG0561	phosphatase activity
HFS76_RS15240	COG2814	Major facilitator Superfamily
HFS76_RS15245	COG0671	phosphoesterase, PA-phosphatase related
HFS76_RS15250	COG1349	DNA-binding transcription factor activity
HFS76_RS15255	COG1686	Belongs to the peptidase S11 family
HFS76_RS15260	COG0625	glutathione transferase activity
HFS76_RS15265	COG2133	pyrroloquinoline quinone binding
HFS76_RS15290	COG0747	negative chemotaxis
HFS76_RS15315	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFS76_RS15320	COG1882	Formate acetyltransferase
HFS76_RS15325	COG0561	phosphatase activity
HFS76_RS15345	COG0488	(ABC) transporter
HFS76_RS15350	COG1376	ErfK ybiS ycfS ynhG family protein
HFS76_RS15355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFS76_RS15370	COG2194	sulfuric ester hydrolase activity
HFS76_RS15375	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HFS76_RS15390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS76_RS15395	COG0765	amino acid transport
HFS76_RS15400	COG1126	abc transporter atp-binding protein
HFS76_RS15405	COG0668	transmembrane transport
HFS76_RS15415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFS76_RS15425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFS76_RS15440	COG0513	Belongs to the DEAD box helicase family
HFS76_RS15445	COG1309	transcriptional regulator
HFS76_RS15455	COG1131	(ABC) transporter
HFS76_RS15460	COG0842	Transport permease protein
HFS76_RS15465	COG0842	Transport permease protein
HFS76_RS15475	COG3568	Endonuclease Exonuclease Phosphatase
HFS76_RS15480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFS76_RS15485	COG0392	lysyltransferase activity
HFS76_RS15505	COG0670	Belongs to the BI1 family
HFS76_RS15515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HFS76_RS15525	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFS76_RS15575	COG1881	PFAM PEBP family protein
HFS76_RS15605	COG2246	polysaccharide biosynthetic process
HFS76_RS15715	COG3646	Phage regulatory protein
HFS76_RS15790	COG0305	Participates in initiation and elongation during chromosome replication
HFS76_RS15860	COG4712	double-strand break repair protein
HFS76_RS15915	COG0582	viral genome integration into host DNA
HFS76_RS15920	COG4677	pectinesterase activity
HFS76_RS15930	COG0561	phosphatase activity
HFS76_RS15940	COG4149	molybdate abc transporter
HFS76_RS15945	COG0725	ABC transporter, periplasmic molybdate-binding protein
HFS76_RS15955	COG3585	molybdate ion transport
HFS76_RS15955	COG2005	Transcriptional regulator
HFS76_RS15960	COG1119	ATPase activity
HFS76_RS15985	COG2017	converts alpha-aldose to the beta-anomer
HFS76_RS15995	COG1120	ATPase activity
HFS76_RS16000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFS76_RS16015	COG0511	ligase activity, forming carbon-carbon bonds
HFS76_RS16015	COG5016	pyruvate
HFS76_RS16025	COG0471	metal ion transport
HFS76_RS16025	COG0490	domain, Protein
HFS76_RS16030	COG0583	DNA-binding transcription factor activity
HFS76_RS16035	COG0583	DNA-binding transcription factor activity
HFS76_RS16045	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS76_RS16045	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS76_RS16050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFS76_RS16060	COG1230	cation diffusion facilitator family transporter
HFS76_RS16100	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HFS76_RS16105	COG2885	chlorophyll binding
HFS76_RS16115	COG3064	Membrane
HFS76_RS16120	COG0848	biopolymer transport protein
HFS76_RS16125	COG0811	peptide transport
HFS76_RS16130	COG0824	Thioesterase
HFS76_RS16135	COG3790	cyd operon protein YbgE
HFS76_RS16140	COG4890	Cyd operon protein YbgT
HFS76_RS16145	COG1294	oxidase, subunit
HFS76_RS16150	COG1271	oxidase subunit
HFS76_RS16155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFS76_RS16165	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFS76_RS16170	COG0567	Dehydrogenase, E1 component
HFS76_RS16185	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HFS76_RS16205	COG3180	Ammonia monooxygenase
HFS76_RS16220	COG1984	allophanate hydrolase subunit 2
HFS76_RS16225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HFS76_RS16270	COG2205	protein histidine kinase activity
HFS76_RS16275	COG0745	RESPONSE REGULATOR receiver
HFS76_RS16285	COG1982	Orn Lys Arg decarboxylase major
HFS76_RS16290	COG0531	amino acid
HFS76_RS16300	COG0033	Phosphoglucomutase
HFS76_RS16310	COG0596	Alpha beta hydrolase
HFS76_RS16330	COG0735	belongs to the Fur family
HFS76_RS16335	COG0583	DNA-binding transcription factor activity
HFS76_RS16340	COG1053	succinate dehydrogenase
HFS76_RS16380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFS76_RS16385	COG1940	carbohydrate kinase activity
HFS76_RS16385	COG1846	Transcriptional regulator
HFS76_RS16390	COG0647	UMP catabolic process
HFS76_RS16395	COG0367	asparagine synthase
HFS76_RS16445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFS76_RS16455	COG1702	phosphate starvation-inducible protein PhoH
HFS76_RS16480	COG0765	amino acid transport
HFS76_RS16485	COG0765	amino acid transport
HFS76_RS16490	COG1126	abc transporter atp-binding protein
HFS76_RS16505	COG0443	Heat shock 70 kDa protein
HFS76_RS16510	COG2214	Heat shock protein DnaJ domain protein
HFS76_RS16520	COG2214	Heat shock protein DnaJ domain protein
HFS76_RS16535	COG2888	peptidyl-tyrosine sulfation
HFS76_RS16540	COG3829	transcription factor binding
HFS76_RS16540	COG3290	protein histidine kinase activity
HFS76_RS16570	COG1466	dna polymerase III delta subunit
HFS76_RS16590	COG0799	negative regulation of ribosome biogenesis
HFS76_RS16600	COG0768	penicillin binding
HFS76_RS16605	COG0772	Belongs to the SEDS family
HFS76_RS16615	COG1686	Belongs to the peptidase S11 family
HFS76_RS16630	COG0583	DNA-binding transcription factor activity
HFS76_RS16645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFS76_RS16665	COG3069	C4-dicarboxylate transmembrane transporter activity
HFS76_RS16670	COG4565	transcriptional regulatory protein
HFS76_RS16675	COG3290	protein histidine kinase activity
HFS76_RS16680	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HFS76_RS16690	COG2301	Belongs to the HpcH HpaI aldolase family
HFS76_RS16695	COG3051	citrate lyase alpha subunit
HFS76_RS16705	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HFS76_RS16710	COG0471	metal ion transport
HFS76_RS16715	COG3719	Belongs to the RNase T2 family
HFS76_RS16720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFS76_RS16725	COG1063	alcohol dehydrogenase
HFS76_RS16745	COG0243	molybdopterin cofactor binding
HFS76_RS16765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFS76_RS16770	COG0583	DNA-binding transcription factor activity
HFS76_RS16775	COG3969	phosphoadenosine phosphosulfate
HFS76_RS16780	COG1475	DNA binding
HFS76_RS16785	COG0436	Aminotransferase
HFS76_RS16790	COG0371	Dehydrogenase
HFS76_RS16795	COG2879	small protein
HFS76_RS16800	COG1966	Carbon starvation protein
HFS76_RS16810	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS16815	COG3433	isochorismatase activity
HFS76_RS16815	COG1535	isochorismatase
HFS76_RS16820	COG1021	2,3-dihydroxybenzoate-AMP ligase
HFS76_RS16825	COG1169	isochorismate synthase
HFS76_RS16830	COG4592	Periplasmic binding protein
HFS76_RS16840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFS76_RS16845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFS76_RS16850	COG1120	ATPase activity
HFS76_RS16855	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HFS76_RS16860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFS76_RS16860	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HFS76_RS16865	COG3251	PFAM MbtH domain protein
HFS76_RS16870	COG2382	esterase
HFS76_RS16875	COG4771	TonB-dependent receptor
HFS76_RS16880	COG2977	Belongs to the P-Pant transferase superfamily
HFS76_RS16905	COG2315	Protein conserved in bacteria
HFS76_RS16920	COG0668	transmembrane transport
HFS76_RS16925	COG1113	amino acid transport
HFS76_RS16935	COG3059	membrane
HFS76_RS16945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFS76_RS16950	COG2207	Transcriptional regulator
HFS76_RS16970	COG2246	polysaccharide biosynthetic process
HFS76_RS16975	COG0463	Glycosyl transferase, family 2
HFS76_RS17055	COG2501	S4 domain
HFS76_RS17060	COG1988	membrane-bound metal-dependent
HFS76_RS17080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFS76_RS17090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HFS76_RS17095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFS76_RS17100	COG0549	Belongs to the carbamate kinase family
HFS76_RS17110	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFS76_RS17115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFS76_RS17120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HFS76_RS17125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFS76_RS17130	COG3257	ureidoglycine aminohydrolase activity
HFS76_RS17135	COG1929	Belongs to the glycerate kinase type-1 family
HFS76_RS17140	COG2233	PERMEase
HFS76_RS17150	COG1953	Uracil, thiamine, allantoin
HFS76_RS17160	COG2084	Dehydrogenase
HFS76_RS17165	COG3622	Belongs to the hyi family
HFS76_RS17170	COG3960	tartronate-semialdehyde synthase activity
HFS76_RS17205	COG1464	Belongs to the NlpA lipoprotein family
HFS76_RS17215	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HFS76_RS17220	COG4181	ATPase activity
HFS76_RS17225	COG2755	lipolytic protein G-D-S-L family
HFS76_RS17230	COG0300	oxidoreductase activity
HFS76_RS17235	COG3118	belongs to the thioredoxin family
HFS76_RS17240	COG0390	transport system, permease component
HFS76_RS17245	COG4619	ABC transporter
HFS76_RS17250	COG0330	HflC and HflK could
HFS76_RS17255	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFS76_RS17265	COG2217	Heavy metal translocating P-type atpase
HFS76_RS17275	COG3735	TraB family
HFS76_RS17290	COG2223	nitrite transmembrane transporter activity
HFS76_RS17295	COG4651	solute:proton antiporter activity
HFS76_RS17295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFS76_RS17300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS17345	COG2832	Protein of unknown function (DUF454)
HFS76_RS17350	COG3923	Primosomal replication protein n
HFS76_RS17360	COG5464	transposase or invertase
HFS76_RS17365	COG3264	Mechanosensitive ion channel
HFS76_RS17365	COG1196	nuclear chromosome segregation
HFS76_RS17370	COG1309	transcriptional regulator
HFS76_RS17375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS76_RS17380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFS76_RS17395	COG0110	maltose O-acetyltransferase activity
HFS76_RS17415	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HFS76_RS17425	COG3695	enzyme binding
HFS76_RS17430	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HFS76_RS17435	COG1946	Acyl-CoA thioesterase
HFS76_RS17440	COG0004	ammonium transporteR
HFS76_RS17445	COG0347	Belongs to the P(II) protein family
HFS76_RS17450	COG1132	(ABC) transporter
HFS76_RS17455	COG1132	(ABC) transporter
HFS76_RS17460	COG1522	sequence-specific DNA binding
HFS76_RS17475	COG4533	DNA binding
HFS76_RS17485	COG0824	Thioesterase
HFS76_RS17490	COG1555	photosystem II stabilization
HFS76_RS17495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFS76_RS17505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HFS76_RS17525	COG0271	Belongs to the BolA IbaG family
HFS76_RS17530	COG3056	Lipoprotein
HFS76_RS17535	COG2223	nitrite transmembrane transporter activity
HFS76_RS17540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFS76_RS17545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFS76_RS17550	COG1845	cytochrome c oxidase, subunit III
HFS76_RS17555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HFS76_RS17575	COG2814	Major facilitator Superfamily
HFS76_RS17605	COG2188	Transcriptional regulator
HFS76_RS17640	COG0142	geranyltranstransferase activity
HFS76_RS17650	COG0667	Aldo Keto reductase
HFS76_RS17655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HFS76_RS17660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HFS76_RS17675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFS76_RS17675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFS76_RS17685	COG4238	major outer membrane lipoprotein
HFS76_RS17705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFS76_RS17715	COG1862	Preprotein translocase
HFS76_RS17735	COG0450	alkyl hydroperoxide reductase
HFS76_RS17740	COG0366	Alpha amylase catalytic
HFS76_RS17755	COG5002	protein histidine kinase activity
HFS76_RS17765	COG0420	3'-5' exonuclease activity
HFS76_RS17770	COG0419	ATPase involved in DNA repair
HFS76_RS17775	COG2814	Major facilitator Superfamily
HFS76_RS17780	COG1940	carbohydrate kinase activity
HFS76_RS17795	COG4126	flavin adenine dinucleotide binding
HFS76_RS17815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFS76_RS17820	COG3706	GGDEF domain
HFS76_RS17865	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HFS76_RS17870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HFS76_RS17885	COG0113	porphobilinogen synthase activity
HFS76_RS17920	COG1280	lysine exporter protein (LysE YggA)
HFS76_RS17940	COG1294	oxidase, subunit
HFS76_RS17945	COG1271	oxidase subunit
HFS76_RS17965	COG2814	Major facilitator Superfamily
HFS76_RS17975	COG0789	Transcriptional regulator
HFS76_RS17980	COG2217	Heavy metal translocating P-type atpase
HFS76_RS17985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS76_RS18030	COG2200	EAL domain
HFS76_RS18045	COG3539	Fimbrial protein
HFS76_RS18050	COG3121	Chaperone
HFS76_RS18055	COG3188	usher protein
HFS76_RS18090	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFS76_RS18105	COG2814	Major facilitator Superfamily
HFS76_RS18125	COG0582	viral genome integration into host DNA
HFS76_RS18295	COG1783	phage Terminase large subunit
HFS76_RS18300	COG3728	DNA packaging
HFS76_RS18320	COG3772	lysozyme
HFS76_RS18480	COG4712	double-strand break repair protein
HFS76_RS18540	COG0582	viral genome integration into host DNA
HFS76_RS18580	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFS76_RS18585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HFS76_RS18590	COG1690	Belongs to the RtcB family
HFS76_RS18600	COG3034	peptidoglycan biosynthetic process
HFS76_RS18605	COG0121	glutamine amidotransferase
HFS76_RS18620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFS76_RS18695	COG3209	COG3209 Rhs family protein
HFS76_RS18720	COG4372	Transposase
HFS76_RS18745	COG0582	viral genome integration into host DNA
HFS76_RS18765	COG2226	methyltransferase
HFS76_RS18775	COG0741	lytic transglycosylase activity
HFS76_RS18775	COG1388	LysM domain
HFS76_RS18780	COG2226	methyltransferase
HFS76_RS18790	COG2814	Major facilitator Superfamily
HFS76_RS18795	COG0583	DNA-binding transcription factor activity
HFS76_RS18800	COG0656	L-ascorbic acid biosynthetic process
HFS76_RS18835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HFS76_RS18860	COG1720	tRNA m6t6A37 methyltransferase activity
HFS76_RS18870	COG3015	lipoprotein NlpE involved in copper resistance
HFS76_RS18875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HFS76_RS18890	COG4568	rho-dependent transcription termination
HFS76_RS18900	COG0346	lactoylglutathione lyase activity
HFS76_RS18905	COG1982	Orn Lys Arg decarboxylase major
HFS76_RS18965	COG0575	Belongs to the CDS family
HFS76_RS19015	COG0477	Major facilitator Superfamily
HFS76_RS19025	COG3835	regulator
HFS76_RS19050	COG2860	membrane
HFS76_RS19080	COG3539	Fimbrial protein
HFS76_RS19085	COG3539	Fimbrial protein
HFS76_RS19090	COG3121	Chaperone
HFS76_RS19095	COG3188	usher protein
HFS76_RS19110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFS76_RS19115	COG1120	ATPase activity
HFS76_RS19120	COG4774	siderophore transport
HFS76_RS19125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFS76_RS19130	COG1643	Atp-dependent helicase
HFS76_RS19135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HFS76_RS19155	COG0617	tRNA 3'-terminal CCA addition
HFS76_RS19160	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFS76_RS19180	COG0726	polysaccharide deacetylase
HFS76_RS19185	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS19205	COG3539	Fimbrial protein
HFS76_RS19210	COG0842	Transport permease protein
HFS76_RS19215	COG1131	(ABC) transporter
HFS76_RS19220	COG0288	reversible hydration of carbon dioxide
HFS76_RS19230	COG4993	Dehydrogenase
HFS76_RS19235	COG2132	Multicopper oxidase
HFS76_RS19255	COG1349	DNA-binding transcription factor activity
HFS76_RS19325	COG3064	Membrane
HFS76_RS19340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFS76_RS19345	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFS76_RS19350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HFS76_RS19365	COG2211	Major facilitator Superfamily
HFS76_RS19370	COG3940	Belongs to the glycosyl hydrolase 43 family
HFS76_RS19375	COG3725	Membrane protein required for beta-lactamase induction
HFS76_RS19390	COG4969	Belongs to the N-Me-Phe pilin family
HFS76_RS19395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HFS76_RS19400	COG1459	type II secretion system
HFS76_RS19425	COG0583	DNA-binding transcription factor activity
HFS76_RS19430	COG0667	Aldo Keto reductase
HFS76_RS19435	COG0494	nUDIX hydrolase
HFS76_RS19455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFS76_RS19460	COG0849	cell division
HFS76_RS19485	COG0772	Belongs to the SEDS family
HFS76_RS19500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFS76_RS19505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HFS76_RS19510	COG0768	penicillin binding
HFS76_RS19600	COG0586	Pfam SNARE associated Golgi protein
HFS76_RS19640	COG0675	Transposase, IS605 OrfB family
HFS76_RS19655	COG0417	DNA replication proofreading
HFS76_RS19685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HFS76_RS19720	COG3119	arylsulfatase activity
HFS76_RS19740	COG2271	Major facilitator Superfamily
HFS76_RS19750	COG0644	oxidoreductase
HFS76_RS19895	COG1047	Peptidyl-prolyl cis-trans
HFS76_RS19910	COG0196	riboflavin kinase activity
HFS76_RS19935	COG0583	DNA-binding transcription factor activity
HFS76_RS19955	COG0641	radical SAM
HFS76_RS19960	COG3119	arylsulfatase activity
HFS76_RS19970	COG0737	Belongs to the 5'-nucleotidase family
HFS76_RS19985	COG0583	DNA-binding transcription factor activity
HFS76_RS20005	COG3121	Chaperone
HFS76_RS20010	COG3539	Fimbrial protein
HFS76_RS20025	COG3188	usher protein
HFS76_RS20090	COG4735	regulation of single-species biofilm formation
HFS76_RS20095	COG1584	GPR1 FUN34 yaaH family protein
HFS76_RS20100	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFS76_RS20110	COG1115	amino acid carrier protein
HFS76_RS20120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HFS76_RS20130	COG0460	homoserine dehydrogenase
HFS76_RS20130	COG0527	aspartate kinase activity
HFS76_RS20140	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HFS76_RS20150	COG0745	RESPONSE REGULATOR receiver
HFS76_RS20170	COG3121	Chaperone
HFS76_RS20190	COG4452	Inner membrane protein CreD
HFS76_RS20195	COG2205	protein histidine kinase activity
HFS76_RS20200	COG0745	RESPONSE REGULATOR receiver
HFS76_RS20205	COG3045	CreA protein
HFS76_RS20210	COG3708	Transcriptional regulator
HFS76_RS20210	COG2207	Transcriptional regulator
HFS76_RS20235	COG0488	(ABC) transporter
HFS76_RS20250	COG0560	Phosphoserine phosphatase
HFS76_RS20255	COG3726	membrane protein affecting hemolysin expression
HFS76_RS20270	COG3539	Fimbrial protein
HFS76_RS20275	COG3121	Chaperone
HFS76_RS20280	COG3188	usher protein
HFS76_RS20310	COG1328	CTP reductase activity
HFS76_RS20315	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFS76_RS20320	COG0084	hydrolase, TatD family'
HFS76_RS20325	COG4667	esterase of the alpha-beta hydrolase superfamily
HFS76_RS20335	COG2823	Periplasmic or secreted lipoprotein
HFS76_RS20345	COG1011	Hydrolase
HFS76_RS20355	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HFS76_RS20385	COG3706	GGDEF domain
HFS76_RS20390	COG4114	ferric iron reductase
HFS76_RS20395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFS76_RS20400	COG2197	response regulator
HFS76_RS20405	COG2197	response regulator
HFS76_RS20410	COG2966	Psort location CytoplasmicMembrane, score
HFS76_RS20425	COG1484	DNA-dependent DNA replication
HFS76_RS20440	COG0840	transmembrane signaling receptor activity
HFS76_RS20445	COG1966	Carbon starvation protein
HFS76_RS20450	COG2879	small protein
HFS76_RS20455	COG0523	cobalamin synthesis protein
HFS76_RS20465	COG1280	lysine exporter protein (LysE YggA)
HFS76_RS20470	COG3586	endonuclease activity
HFS76_RS20485	COG1012	belongs to the aldehyde dehydrogenase family
HFS76_RS20490	COG5464	transposase or invertase
HFS76_RS20500	COG2733	membrane
HFS76_RS20505	COG0477	Major facilitator Superfamily
HFS76_RS20510	COG3366	ferrous iron transmembrane transporter activity
HFS76_RS20515	COG0700	Nucleoside recognition
HFS76_RS20520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFS76_RS20525	COG0583	DNA-binding transcription factor activity
HFS76_RS20545	COG2186	Transcriptional regulator
HFS76_RS20550	COG0412	Dienelactone hydrolase
HFS76_RS20575	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HFS76_RS20600	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HFS76_RS20615	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HFS76_RS20620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HFS76_RS20640	COG3550	peptidyl-serine autophosphorylation
HFS76_RS20690	COG0494	nUDIX hydrolase
HFS76_RS20740	COG1064	alcohol dehydrogenase
HFS76_RS20745	COG3265	gluconokinase activity
HFS76_RS20750	COG1063	alcohol dehydrogenase
HFS76_RS20755	COG1028	Short-chain dehydrogenase reductase Sdr
HFS76_RS20760	COG2610	gluconate transmembrane transporter activity
HFS76_RS20765	COG1609	Transcriptional regulator
HFS76_RS20770	COG0795	lipopolysaccharide-transporting ATPase activity
HFS76_RS20775	COG0795	lipopolysaccharide-transporting ATPase activity
HFS76_RS20785	COG2927	DNA polymerase III (CHI subunit)
HFS76_RS20825	COG2731	YhcH YjgK YiaL family protein
HFS76_RS20845	COG1288	antiporter activity
HFS76_RS20850	COG1438	arginine binding
HFS76_RS20900	COG1263	PTS System
HFS76_RS20900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS76_RS20905	COG0366	Alpha amylase catalytic
HFS76_RS20930	COG3711	transcriptional antiterminator
HFS76_RS20930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS20945	COG3964	amidohydrolase
HFS76_RS20980	COG0312	modulator of DNA gyrase
HFS76_RS20990	COG1082	Xylose isomerase domain protein TIM barrel
HFS76_RS21000	COG2814	Major facilitator Superfamily
HFS76_RS21005	COG0673	inositol 2-dehydrogenase activity
HFS76_RS21010	COG3962	Belongs to the TPP enzyme family
HFS76_RS21015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS21025	COG1082	Xylose isomerase domain protein TIM barrel
HFS76_RS21030	COG5520	Belongs to the glycosyl hydrolase 30 family
HFS76_RS21060	COG3718	enzyme involved in inositol metabolism
HFS76_RS21065	COG0477	Major facilitator Superfamily
HFS76_RS21065	COG2814	Major facilitator Superfamily
HFS76_RS21075	COG0477	Major facilitator Superfamily
HFS76_RS21075	COG2814	Major facilitator Superfamily
HFS76_RS21080	COG1737	Transcriptional regulator
HFS76_RS21080	COG0837	glucose binding
HFS76_RS21085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFS76_RS21100	COG3964	amidohydrolase
HFS76_RS21105	COG2271	Major facilitator Superfamily
HFS76_RS21110	COG2105	PFAM AIG2 family protein
HFS76_RS21130	COG1253	flavin adenine dinucleotide binding
HFS76_RS21140	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HFS76_RS21155	COG1733	regulation of RNA biosynthetic process
HFS76_RS21160	COG0702	epimerase
HFS76_RS21165	COG0697	spore germination
HFS76_RS21175	COG1113	amino acid transport
HFS76_RS21180	COG0545	Peptidyl-prolyl cis-trans isomerase
HFS76_RS21185	COG3061	Opacity-associated protein A
HFS76_RS21200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFS76_RS21220	COG3477	response to acidic pH
HFS76_RS21265	COG1073	alpha beta
HFS76_RS21270	COG3650	response to hydrogen peroxide
HFS76_RS21280	COG1960	acyl-CoA dehydrogenase activity
HFS76_RS21285	COG0754	glutathionylspermidine amidase activity
HFS76_RS21290	COG5463	Belongs to the UPF0441 family
HFS76_RS21295	COG3766	membrane
HFS76_RS21305	COG1842	Phage shock protein A
HFS76_RS21310	COG3789	protein conserved in bacteria
HFS76_RS21320	COG0557	exoribonuclease II activity
HFS76_RS21335	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HFS76_RS21340	COG0330	HflC and HflK could
HFS76_RS21345	COG0330	HflC and HflK could
HFS76_RS21350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFS76_RS21375	COG0802	atpase or kinase
HFS76_RS21380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HFS76_RS21380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HFS76_RS21405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS76_RS21425	COG1511	domain protein
HFS76_RS21425	COG3264	Mechanosensitive ion channel
HFS76_RS21445	COG1053	succinate dehydrogenase
HFS76_RS21450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFS76_RS21480	COG5510	response to toxic substance
HFS76_RS21520	COG0531	amino acid
HFS76_RS21525	COG3030	protein affecting phage T7 exclusion by the F plasmid
HFS76_RS21530	COG1027	Aspartate ammonia-lyase
HFS76_RS21535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HFS76_RS21550	COG1309	transcriptional regulator
HFS76_RS21565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HFS76_RS21565	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HFS76_RS21570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFS76_RS21575	COG1063	alcohol dehydrogenase
HFS76_RS21580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFS76_RS21585	COG1063	alcohol dehydrogenase
HFS76_RS21590	COG3716	PTS system mannose fructose sorbose family IID component
HFS76_RS21600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS76_RS21605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS76_RS21605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS76_RS21645	COG2197	response regulator
HFS76_RS21665	COG3381	protein complex oligomerization
HFS76_RS21670	COG3302	dmso reductase anchor subunit
HFS76_RS21675	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS21680	COG0243	molybdopterin cofactor binding
HFS76_RS21685	COG3290	protein histidine kinase activity
HFS76_RS21690	COG4565	transcriptional regulatory protein
HFS76_RS21700	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HFS76_RS21705	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS76_RS21705	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS76_RS21720	COG2169	Transcriptional regulator
HFS76_RS21725	COG1982	Orn Lys Arg decarboxylase major
HFS76_RS21730	COG2207	Transcriptional regulator
HFS76_RS21735	COG0531	amino acid
HFS76_RS21765	COG2824	Alkylphosphonate utilization operon protein PhnA
HFS76_RS21770	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HFS76_RS21790	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HFS76_RS21800	COG1301	dicarboxylic acid transport
HFS76_RS21805	COG4235	cytochrome complex assembly
HFS76_RS21810	COG1138	Cytochrome C-type biogenesis protein
HFS76_RS21815	COG3301	Polysulphide reductase, NrfD
HFS76_RS21820	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS21825	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HFS76_RS21835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFS76_RS21840	COG3162	membrane
HFS76_RS21850	COG1346	cytolysis
HFS76_RS21855	COG1380	Effector of murein hydrolase LrgA
HFS76_RS21860	COG0583	DNA-binding transcription factor activity
HFS76_RS21865	COG0025	NhaP-type Na H and K H
HFS76_RS21870	COG2252	PERMEase
HFS76_RS21890	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HFS76_RS21950	COG2315	Protein conserved in bacteria
HFS76_RS22000	COG0735	belongs to the Fur family
HFS76_RS22015	COG0534	Mate efflux family protein
HFS76_RS22025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HFS76_RS22080	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFS76_RS22105	COG0527	aspartate kinase activity
HFS76_RS22185	COG2246	polysaccharide biosynthetic process
HFS76_RS22215	COG5301	cellulose 1,4-beta-cellobiosidase activity
HFS76_RS22255	COG3122	Protein conserved in bacteria
HFS76_RS22320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFS76_RS22360	COG0151	Belongs to the GarS family
HFS76_RS22365	COG2204	response regulator
HFS76_RS22425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFS76_RS22430	COG2104	thiamine diphosphate biosynthetic process
HFS76_RS22490	COG0250	Participates in transcription elongation, termination and antitermination
HFS76_RS22600	COG0583	DNA-binding transcription factor activity
HFS76_RS22635	COG2207	Transcriptional regulator
HFS76_RS22645	COG0371	Dehydrogenase
HFS76_RS22650	COG3738	Protein conserved in bacteria
HFS76_RS22665	COG0737	Belongs to the 5'-nucleotidase family
HFS76_RS22680	COG0668	transmembrane transport
HFS76_RS22685	COG0527	aspartate kinase activity
HFS76_RS22685	COG0460	homoserine dehydrogenase
HFS76_RS22690	COG0626	cystathionine gamma-synthase activity
HFS76_RS22715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFS76_RS22720	COG1609	Transcriptional regulator
HFS76_RS22725	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HFS76_RS22740	COG1575	Belongs to the MenA family. Type 1 subfamily
HFS76_RS22755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HFS76_RS22765	COG1494	fructose-1,6-bisphosphatase
HFS76_RS22775	COG3152	Membrane
HFS76_RS22805	COG1879	ABC-type sugar transport system periplasmic component
HFS76_RS22830	COG1070	Carbohydrate kinase
HFS76_RS22850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFS76_RS22865	COG2211	Major facilitator Superfamily
HFS76_RS22890	COG3678	ATP-independent chaperone mediated protein folding
HFS76_RS22895	COG0745	RESPONSE REGULATOR receiver
HFS76_RS22900	COG2205	protein histidine kinase activity
HFS76_RS22910	COG2258	MOSC domain
HFS76_RS22915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFS76_RS22925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HFS76_RS22970	COG1454	alcohol dehydrogenase
HFS76_RS22985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFS76_RS23005	COG0326	Molecular chaperone. Has ATPase activity
HFS76_RS23030	COG0437	4 iron, 4 sulfur cluster binding
HFS76_RS23035	COG2864	formate dehydrogenase
HFS76_RS23050	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HFS76_RS23060	COG4680	protein conserved in bacteria
HFS76_RS23065	COG5499	transcription regulator containing HTH domain
HFS76_RS23070	COG0456	acetyltransferase
HFS76_RS23085	COG1011	Hydrolase
HFS76_RS23090	COG1349	DNA-binding transcription factor activity
HFS76_RS23095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS23105	COG3684	Belongs to the aldolase LacD family
HFS76_RS23115	COG2017	converts alpha-aldose to the beta-anomer
HFS76_RS23125	COG1501	Belongs to the glycosyl hydrolase 31 family
HFS76_RS23135	COG2211	Major facilitator Superfamily
HFS76_RS23170	COG0561	phosphatase activity
HFS76_RS23225	COG0204	Acyl-transferase
HFS76_RS23240	COG3084	Protein conserved in bacteria
HFS76_RS23245	COG0746	molybdenum cofactor guanylyltransferase activity
HFS76_RS23250	COG1763	Mo-molybdopterin cofactor biosynthetic process
HFS76_RS23290	COG1739	Uncharacterized protein family UPF0029
HFS76_RS23335	COG0805	protein transport
HFS76_RS23380	COG0641	radical SAM
HFS76_RS23400	COG0561	phosphatase activity
HFS76_RS23405	COG2267	carboxylic ester hydrolase activity
HFS76_RS23410	COG1280	lysine exporter protein (LysE YggA)
HFS76_RS23460	COG1011	Hydrolase
HFS76_RS23535	COG2959	enzyme of heme biosynthesis
HFS76_RS23540	COG3071	HemY protein
HFS76_RS23585	COG2244	polysaccharide biosynthetic process
HFS76_RS23590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HFS76_RS23595	COG0456	acetyltransferase
HFS76_RS23600	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HFS76_RS23600	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HFS76_RS23605	COG1088	dTDP-glucose 4,6-dehydratase activity
HFS76_RS23610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HFS76_RS23640	COG3118	belongs to the thioredoxin family
HFS76_RS23715	COG3978	acetolactate synthase activity
HFS76_RS23780	COG2186	Transcriptional regulator
HFS76_RS23785	COG0477	Major facilitator Superfamily
HFS76_RS23790	COG1609	Transcriptional regulator
HFS76_RS23795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS76_RS23805	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFS76_RS23840	COG1522	sequence-specific DNA binding
HFS76_RS23845	COG0716	FMN binding
HFS76_RS23860	COG3312	ion transport
HFS76_RS23920	COG4533	DNA binding
HFS76_RS23925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HFS76_RS23930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFS76_RS23930	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFS76_RS23930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFS76_RS23935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFS76_RS23940	COG0573	inorganic phosphate transmembrane transporter activity
HFS76_RS23945	COG0581	inorganic phosphate transmembrane transporter activity
HFS76_RS23955	COG0704	Plays a role in the regulation of phosphate uptake
HFS76_RS23960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFS76_RS23970	COG2252	PERMEase
HFS76_RS23980	COG0431	NADPH-dependent FMN reductase
HFS76_RS23985	COG2091	lysine biosynthetic process via aminoadipic acid
HFS76_RS24110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFS76_RS24135	COG5001	Diguanylate cyclase
HFS76_RS24170	COG0714	Associated with various cellular activities
HFS76_RS24180	COG0629	single-stranded DNA binding
HFS76_RS24225	COG0633	Ferredoxin
HFS76_RS24285	COG3385	transposase activity
HFS76_RS24415	COG3300	MHYT domain
HFS76_RS24415	COG5001	Diguanylate cyclase
HFS76_RS24470	COG3385	transposase activity
HFS76_RS24515	COG4974	Belongs to the 'phage' integrase family
HFS76_RS24655	COG0616	signal peptide processing
HFS76_RS24845	COG1192	Involved in chromosome partitioning
HFS76_RS24925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone