locus-tag	class	description
HEC99_RS00030	COG4948	Mandelate Racemase Muconate Lactonizing
HEC99_RS00035	COG2271	Major facilitator Superfamily
HEC99_RS00040	COG0561	phosphatase activity
HEC99_RS00045	COG2186	Transcriptional regulator
HEC99_RS00050	COG3734	2-keto-3-deoxy-galactonokinase
HEC99_RS00055	COG0800	Aldolase
HEC99_RS00065	COG2271	Major facilitator Superfamily
HEC99_RS00070	COG2198	Histidine kinase
HEC99_RS00070	COG2205	protein histidine kinase activity
HEC99_RS00070	COG0784	Response regulator, receiver
HEC99_RS00075	COG1879	ABC-type sugar transport system periplasmic component
HEC99_RS00080	COG0745	RESPONSE REGULATOR receiver
HEC99_RS00085	COG3005	denitrification pathway
HEC99_RS00100	COG1858	cytochrome C peroxidase
HEC99_RS00105	COG4133	protoheme IX ABC transporter activity
HEC99_RS00110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC99_RS00115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC99_RS00120	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC99_RS00130	COG1138	Cytochrome C-type biogenesis protein
HEC99_RS00140	COG3088	subunit of a heme lyase
HEC99_RS00140	COG4235	cytochrome complex assembly
HEC99_RS00145	COG0823	Involved in the tonB-independent uptake of proteins
HEC99_RS00150	COG5645	(Lipo)protein
HEC99_RS00170	COG2149	membrane
HEC99_RS00180	COG0641	radical SAM
HEC99_RS00190	COG2610	gluconate transmembrane transporter activity
HEC99_RS00195	COG0583	DNA-binding transcription factor activity
HEC99_RS00205	COG2814	Major facilitator Superfamily
HEC99_RS00230	COG0028	Belongs to the TPP enzyme family
HEC99_RS00235	COG0440	acetolactate synthase activity
HEC99_RS00240	COG1349	DNA-binding transcription factor activity
HEC99_RS00250	COG0738	Major facilitator superfamily
HEC99_RS00300	COG2723	6-phospho-beta-galactosidase activity
HEC99_RS00320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC99_RS00320	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS00325	COG3715	PTS system
HEC99_RS00330	COG3716	PTS system mannose fructose sorbose family IID component
HEC99_RS00345	COG5464	transposase or invertase
HEC99_RS00375	COG1335	isochorismatase
HEC99_RS00385	COG3710	Transcriptional regulator
HEC99_RS00400	COG2771	luxR family
HEC99_RS00445	COG2211	Major facilitator Superfamily
HEC99_RS00450	COG1501	Belongs to the glycosyl hydrolase 31 family
HEC99_RS00455	COG2982	Protein involved in outer membrane biogenesis
HEC99_RS00460	COG2233	PERMEase
HEC99_RS00465	COG0786	glutamate:sodium symporter activity
HEC99_RS00470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEC99_RS00475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC99_RS00480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEC99_RS00500	COG2860	membrane
HEC99_RS00510	COG0583	DNA-binding transcription factor activity
HEC99_RS00515	COG1561	YicC-like family, N-terminal region
HEC99_RS00540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEC99_RS00570	COG1519	Transferase
HEC99_RS00575	COG0859	PFAM glycosyl transferase family 9
HEC99_RS00580	COG0438	transferase activity, transferring glycosyl groups
HEC99_RS00655	COG1216	Glycosyl transferase, family 2
HEC99_RS00660	COG2861	carbohydrate metabolic process
HEC99_RS00665	COG4942	peptidase
HEC99_RS00675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC99_RS00680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HEC99_RS00700	COG2271	Major facilitator Superfamily
HEC99_RS00710	COG1609	Transcriptional regulator
HEC99_RS00715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEC99_RS00725	COG2186	Transcriptional regulator
HEC99_RS00755	COG3722	fumarate hydratase activity
HEC99_RS00765	COG2213	PTS system mannitol-specific
HEC99_RS00765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS00770	COG0625	glutathione transferase activity
HEC99_RS00780	COG3276	selenocysteine insertion sequence binding
HEC99_RS00785	COG1940	carbohydrate kinase activity
HEC99_RS00790	COG1012	belongs to the aldehyde dehydrogenase family
HEC99_RS00805	COG0235	Class ii aldolase
HEC99_RS00810	COG3623	hexulose-6-phosphate isomerase
HEC99_RS00815	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HEC99_RS00820	COG1070	Carbohydrate kinase
HEC99_RS00825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEC99_RS00830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HEC99_RS00835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HEC99_RS00845	COG2731	YhcH YjgK YiaL family protein
HEC99_RS00855	COG1414	Transcriptional regulator
HEC99_RS00860	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC99_RS00865	COG3977	Valine--pyruvate aminotransferase
HEC99_RS00870	COG0366	Alpha amylase catalytic
HEC99_RS00875	COG2992	FlgJ-related protein
HEC99_RS00880	COG2207	Transcriptional regulator
HEC99_RS00880	COG1609	Transcriptional regulator
HEC99_RS00890	COG1070	Carbohydrate kinase
HEC99_RS00895	COG4682	membrane
HEC99_RS00900	COG3274	enterobacterial common antigen metabolic process
HEC99_RS00920	COG2801	Transposase and inactivated derivatives
HEC99_RS00945	COG1278	Cold shock
HEC99_RS00950	COG2944	sequence-specific DNA binding
HEC99_RS00965	COG2885	chlorophyll binding
HEC99_RS00970	COG0243	molybdopterin cofactor binding
HEC99_RS00975	COG0456	acetyltransferase
HEC99_RS00980	COG2818	Glycosylase
HEC99_RS00985	COG5571	outer membrane autotransporter
HEC99_RS01035	COG1609	Transcriptional regulator
HEC99_RS01050	COG0747	negative chemotaxis
HEC99_RS01055	COG0601	transmembrane transport
HEC99_RS01060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEC99_RS01065	COG0444	Belongs to the ABC transporter superfamily
HEC99_RS01070	COG4608	Belongs to the ABC transporter superfamily
HEC99_RS01075	COG0814	amino acid
HEC99_RS01125	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HEC99_RS01135	COG2199	diguanylate cyclase activity
HEC99_RS01135	COG2200	EAL domain
HEC99_RS01150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS01155	COG2200	EAL domain
HEC99_RS01160	COG2982	Protein involved in outer membrane biogenesis
HEC99_RS01165	COG0477	Major facilitator Superfamily
HEC99_RS01170	COG1295	ribonuclease BN
HEC99_RS01175	COG0583	DNA-binding transcription factor activity
HEC99_RS01180	COG2197	response regulator
HEC99_RS01200	COG2188	Transcriptional regulator
HEC99_RS01205	COG2222	sugar isomerase
HEC99_RS01210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS01215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC99_RS01225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC99_RS01230	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEC99_RS01235	COG0671	phosphoesterase, PA-phosphatase related
HEC99_RS01265	COG0306	phosphate transporter
HEC99_RS01270	COG2081	HI0933 family
HEC99_RS01275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC99_RS01280	COG1129	ABC transporter
HEC99_RS01280	COG0842	Transport permease protein
HEC99_RS01285	COG0842	Transport permease protein
HEC99_RS01295	COG2091	lysine biosynthetic process via aminoadipic acid
HEC99_RS01300	COG0628	permease
HEC99_RS01315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEC99_RS01335	COG3714	YhhN family
HEC99_RS01345	COG3776	membrane
HEC99_RS01350	COG0742	ribosomal rna small subunit methyltransferase
HEC99_RS01355	COG0552	protein localization to endoplasmic reticulum
HEC99_RS01360	COG2884	Cell division ATP-binding protein ftsE
HEC99_RS01365	COG2177	Part of the ABC transporter FtsEX involved in
HEC99_RS01445	COG0584	glycerophosphoryl diester phosphodiesterase
HEC99_RS01455	COG0405	Gamma-glutamyltransferase
HEC99_RS01460	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HEC99_RS01475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS01480	COG1247	-acetyltransferase
HEC99_RS01485	COG0673	inositol 2-dehydrogenase activity
HEC99_RS01490	COG1741	Belongs to the pirin family
HEC99_RS01495	COG1609	Transcriptional regulator
HEC99_RS01500	COG3265	gluconokinase activity
HEC99_RS01505	COG2610	gluconate transmembrane transporter activity
HEC99_RS01520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEC99_RS01540	COG0058	SHG alpha-glucan phosphorylase activity
HEC99_RS01545	COG1414	Transcriptional regulator
HEC99_RS01550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEC99_RS01555	COG0129	dihydroxy-acid dehydratase activity
HEC99_RS01565	COG0371	Dehydrogenase
HEC99_RS01580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEC99_RS01595	COG1349	DNA-binding transcription factor activity
HEC99_RS01600	COG4650	regulator
HEC99_RS01610	COG1690	Belongs to the RtcB family
HEC99_RS01620	COG3077	Addiction module antitoxin, RelB DinJ family
HEC99_RS01625	COG3041	Addiction module toxin RelE StbE family
HEC99_RS01635	COG0058	SHG alpha-glucan phosphorylase activity
HEC99_RS01640	COG1640	4-alpha-glucanotransferase
HEC99_RS01645	COG2610	gluconate transmembrane transporter activity
HEC99_RS01665	COG5464	transposase or invertase
HEC99_RS01680	COG1918	ferrous iron import across plasma membrane
HEC99_RS01685	COG2183	response to ionizing radiation
HEC99_RS01690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEC99_RS01695	COG0745	RESPONSE REGULATOR receiver
HEC99_RS01710	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HEC99_RS01720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HEC99_RS01725	COG1011	Hydrolase
HEC99_RS01735	COG0494	nUDIX hydrolase
HEC99_RS01740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEC99_RS01745	COG4972	Pilus assembly protein
HEC99_RS01750	COG3166	PFAM Fimbrial assembly family protein
HEC99_RS01765	COG4796	Type ii and iii secretion system protein
HEC99_RS01780	COG3266	domain, Protein
HEC99_RS01785	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HEC99_RS01790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEC99_RS01830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEC99_RS01865	COG1289	transmembrane transporter activity
HEC99_RS01875	COG1765	OsmC-like protein
HEC99_RS01880	COG3954	Phosphoribulokinase
HEC99_RS01890	COG0429	hydrolase of the alpha beta-hydrolase fold
HEC99_RS01905	COG0488	(ABC) transporter
HEC99_RS01920	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HEC99_RS01925	COG1047	Peptidyl-prolyl cis-trans
HEC99_RS01935	COG0545	Peptidyl-prolyl cis-trans isomerase
HEC99_RS01940	COG2964	Protein conserved in bacteria
HEC99_RS01995	COG0051	transcription antitermination factor activity, RNA binding
HEC99_RS02020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEC99_RS02100	COG0201	protein transport
HEC99_RS02140	COG0789	Transcriptional regulator
HEC99_RS02145	COG3036	rescue of stalled ribosome
HEC99_RS02175	COG0758	DNA mediated transformation
HEC99_RS02185	COG0551	DNA topoisomerase type I activity
HEC99_RS02205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC99_RS02250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC99_RS02255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC99_RS02260	COG1309	transcriptional regulator
HEC99_RS02275	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HEC99_RS02295	COG4145	pantothenate transmembrane transporter activity
HEC99_RS02300	COG3924	membrane
HEC99_RS02305	COG0439	Biotin carboxylase
HEC99_RS02310	COG0511	ligase activity, forming carbon-carbon bonds
HEC99_RS02325	COG0604	alcohol dehydrogenase
HEC99_RS02330	COG2200	EAL domain
HEC99_RS02330	COG2199	diguanylate cyclase activity
HEC99_RS02335	COG1077	Cell shape determining protein MreB Mrl
HEC99_RS02340	COG1792	Involved in formation and maintenance of cell shape
HEC99_RS02345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HEC99_RS02355	COG1530	ribonuclease E activity
HEC99_RS02360	COG3164	Protein of unknown function
HEC99_RS02365	COG0312	modulator of DNA gyrase
HEC99_RS02370	COG0583	DNA-binding transcription factor activity
HEC99_RS02390	COG2732	(Barnase) inhibitor
HEC99_RS02415	COG2188	Transcriptional regulator
HEC99_RS02425	COG0471	metal ion transport
HEC99_RS02430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC99_RS02435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC99_RS02445	COG5016	pyruvate
HEC99_RS02445	COG0511	ligase activity, forming carbon-carbon bonds
HEC99_RS02450	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HEC99_RS02455	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HEC99_RS02465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEC99_RS02470	COG3105	Protein conserved in bacteria
HEC99_RS02475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEC99_RS02495	COG0625	glutathione transferase activity
HEC99_RS02500	COG2969	positive regulation of protein catabolic process
HEC99_RS02530	COG2731	YhcH YjgK YiaL family protein
HEC99_RS02535	COG0402	S-adenosylhomocysteine deaminase activity
HEC99_RS02540	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEC99_RS02545	COG4804	nuclease activity
HEC99_RS02550	COG0493	'glutamate synthase
HEC99_RS02555	COG0070	glutamate synthase
HEC99_RS02555	COG0067	glutamate synthase
HEC99_RS02555	COG0069	glutamate synthase activity
HEC99_RS02560	COG1242	4 iron, 4 sulfur cluster binding
HEC99_RS02565	COG0784	Response regulator, receiver
HEC99_RS02565	COG2198	Histidine kinase
HEC99_RS02565	COG5002	protein histidine kinase activity
HEC99_RS02570	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HEC99_RS02580	COG0515	serine threonine protein kinase
HEC99_RS02585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS02610	COG1137	ATPase activity
HEC99_RS02615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HEC99_RS02620	COG3117	lipopolysaccharide transmembrane transporter activity
HEC99_RS02625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEC99_RS02635	COG0530	calcium, potassium:sodium antiporter activity
HEC99_RS02640	COG1127	ABC transporter
HEC99_RS02645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEC99_RS02650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEC99_RS02655	COG2854	intermembrane phospholipid transfer
HEC99_RS02660	COG3113	response to antibiotic
HEC99_RS02665	COG5007	Belongs to the BolA IbaG family
HEC99_RS02675	COG3423	Transcriptional regulator
HEC99_RS02680	COG0142	geranyltranstransferase activity
HEC99_RS02695	COG0697	spore germination
HEC99_RS02705	COG2027	D-alanyl-D-alanine carboxypeptidase
HEC99_RS02715	COG1534	Rna-binding protein
HEC99_RS02730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEC99_RS02740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEC99_RS02810	COG0513	Belongs to the DEAD box helicase family
HEC99_RS02815	COG0814	amino acid
HEC99_RS02825	COG3034	peptidoglycan biosynthetic process
HEC99_RS02830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEC99_RS02835	COG0826	peptidase U32
HEC99_RS02840	COG0826	peptidase U32
HEC99_RS02845	COG3154	lipid carrier protein
HEC99_RS02850	COG3153	acetyltransferase
HEC99_RS02865	COG0693	protein deglycase activity
HEC99_RS02870	COG0702	epimerase
HEC99_RS02875	COG2823	Periplasmic or secreted lipoprotein
HEC99_RS02890	COG3107	peptidoglycan biosynthetic process
HEC99_RS02895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HEC99_RS02905	COG1063	alcohol dehydrogenase
HEC99_RS02910	COG3775	system Galactitol-specific IIC component
HEC99_RS02915	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC99_RS02920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS02935	COG2721	sulfolactate sulfo-lyase activity
HEC99_RS02945	COG2084	Dehydrogenase
HEC99_RS02950	COG1929	Belongs to the glycerate kinase type-1 family
HEC99_RS02960	COG0583	DNA-binding transcription factor activity
HEC99_RS02980	COG1882	Formate acetyltransferase
HEC99_RS02985	COG1760	l-serine dehydratase
HEC99_RS02990	COG0814	amino acid
HEC99_RS03005	COG1741	Belongs to the pirin family
HEC99_RS03010	COG0583	DNA-binding transcription factor activity
HEC99_RS03015	COG3152	Membrane
HEC99_RS03020	COG0435	Glutathione S-transferase
HEC99_RS03025	COG2259	Doxx family
HEC99_RS03035	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HEC99_RS03040	COG4575	ribosome binding
HEC99_RS03045	COG1422	Protein of unknown function (DUF1090)
HEC99_RS03055	COG0586	Pfam SNARE associated Golgi protein
HEC99_RS03070	COG0673	inositol 2-dehydrogenase activity
HEC99_RS03075	COG2949	membrane
HEC99_RS03080	COG1451	nucleotide metabolic process
HEC99_RS03090	COG1902	pentaerythritol trinitrate reductase activity
HEC99_RS03090	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEC99_RS03100	COG0840	transmembrane signaling receptor activity
HEC99_RS03105	COG0840	transmembrane signaling receptor activity
HEC99_RS03110	COG1695	Transcriptional regulator
HEC99_RS03115	COG2375	cellular response to nickel ion
HEC99_RS03140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HEC99_RS03165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEC99_RS03180	COG4991	sh3 domain protein
HEC99_RS03185	COG3025	triphosphatase activity
HEC99_RS03205	COG2268	Band 7 protein
HEC99_RS03210	COG1585	Membrane protein implicated in regulation of membrane protease activity
HEC99_RS03255	COG3384	dioxygenase
HEC99_RS03260	COG0754	glutathionylspermidine amidase activity
HEC99_RS03275	COG0494	nUDIX hydrolase
HEC99_RS03280	COG3151	Protein conserved in bacteria
HEC99_RS03285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEC99_RS03290	COG3150	esterase
HEC99_RS03300	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HEC99_RS03305	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEC99_RS03320	COG3111	PFAM Bacterial OB fold (BOF) protein
HEC99_RS03325	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HEC99_RS03375	COG0471	metal ion transport
HEC99_RS03385	COG1979	alcohol dehydrogenase
HEC99_RS03390	COG2207	Transcriptional regulator
HEC99_RS03410	COG0848	biopolymer transport protein
HEC99_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS03440	COG0840	transmembrane signaling receptor activity
HEC99_RS03450	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HEC99_RS03455	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS03460	COG5557	Pfam Polysulphide reductase, NrfD
HEC99_RS03465	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEC99_RS03470	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC99_RS03475	COG1773	rubredoxin
HEC99_RS03485	COG0298	carbon dioxide binding
HEC99_RS03500	COG0625	glutathione transferase activity
HEC99_RS03505	COG0754	glutathionylspermidine amidase activity
HEC99_RS03520	COG0246	Mannitol dehydrogenase
HEC99_RS03530	COG2271	Major facilitator Superfamily
HEC99_RS03555	COG1012	belongs to the aldehyde dehydrogenase family
HEC99_RS03560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEC99_RS03570	COG0531	amino acid
HEC99_RS03600	COG2301	Belongs to the HpcH HpaI aldolase family
HEC99_RS03605	COG2030	dehydratase
HEC99_RS03610	COG0427	acetyl-CoA hydrolase
HEC99_RS03625	COG1811	Na channel or pump
HEC99_RS03630	COG1982	Orn Lys Arg decarboxylase major
HEC99_RS03660	COG3171	Protein conserved in bacteria
HEC99_RS03670	COG0252	asparaginase activity
HEC99_RS03680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEC99_RS03695	COG0762	integral membrane protein
HEC99_RS03700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HEC99_RS03705	COG2805	Type II/IV secretion system protein
HEC99_RS03730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEC99_RS03735	COG2356	endonuclease I
HEC99_RS03745	COG2814	Major facilitator Superfamily
HEC99_RS03770	COG1166	arginine decarboxylase activity
HEC99_RS03780	COG2186	Transcriptional regulator
HEC99_RS03790	COG0246	Mannitol dehydrogenase
HEC99_RS03795	COG1063	alcohol dehydrogenase
HEC99_RS03800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HEC99_RS03805	COG2731	YhcH YjgK YiaL family protein
HEC99_RS03820	COG0501	Belongs to the peptidase M48B family
HEC99_RS03825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEC99_RS03830	COG1122	ATPase activity
HEC99_RS03835	COG1122	ATPase activity
HEC99_RS03865	COG0191	fructose-bisphosphate aldolase activity
HEC99_RS03870	COG0668	transmembrane transport
HEC99_RS03880	COG2968	Membrane
HEC99_RS03895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEC99_RS03900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEC99_RS03920	COG0006	proline dipeptidase activity
HEC99_RS03925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC99_RS03930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC99_RS03955	COG2723	6-phospho-beta-galactosidase activity
HEC99_RS03965	COG1272	protein, Hemolysin III
HEC99_RS04020	COG4942	peptidase
HEC99_RS04065	COG3188	usher protein
HEC99_RS04100	COG0814	amino acid
HEC99_RS04115	COG0183	Belongs to the thiolase family
HEC99_RS04125	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS04130	COG2814	Major facilitator Superfamily
HEC99_RS04135	COG1794	racemase activity, acting on amino acids and derivatives
HEC99_RS04140	COG0583	DNA-binding transcription factor activity
HEC99_RS04150	COG1609	Transcriptional regulator
HEC99_RS04170	COG0667	Aldo Keto reductase
HEC99_RS04180	COG0861	Integral membrane protein TerC family
HEC99_RS04210	COG2165	general secretion pathway protein
HEC99_RS04215	COG4795	General secretion pathway protein
HEC99_RS04225	COG4967	type IV pilus modification protein PilV
HEC99_RS04230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEC99_RS04235	COG1025	Belongs to the peptidase M16 family
HEC99_RS04240	COG1074	ATP-dependent DNA helicase activity
HEC99_RS04245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEC99_RS04255	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEC99_RS04270	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HEC99_RS04275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEC99_RS04280	COG2962	Rard protein
HEC99_RS04285	COG2166	iron-sulfur cluster assembly
HEC99_RS04290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEC99_RS04300	COG0583	DNA-binding transcription factor activity
HEC99_RS04305	COG2363	Small membrane protein
HEC99_RS04315	COG1349	DNA-binding transcription factor activity
HEC99_RS04335	COG0738	Major facilitator superfamily
HEC99_RS04340	COG0235	Class ii aldolase
HEC99_RS04345	COG1454	alcohol dehydrogenase
HEC99_RS04355	COG1760	l-serine dehydratase
HEC99_RS04360	COG0814	amino acid
HEC99_RS04365	COG1611	Belongs to the LOG family
HEC99_RS04385	COG3098	single-species biofilm formation
HEC99_RS04395	COG0716	FMN binding
HEC99_RS04405	COG2271	Major facilitator Superfamily
HEC99_RS04410	COG4948	Mandelate Racemase Muconate Lactonizing
HEC99_RS04415	COG4948	Mandelate Racemase Muconate Lactonizing
HEC99_RS04420	COG1929	Belongs to the glycerate kinase type-1 family
HEC99_RS04425	COG4999	Histidine kinase
HEC99_RS04425	COG2205	protein histidine kinase activity
HEC99_RS04425	COG3437	response regulator, receiver
HEC99_RS04425	COG3850	Histidine kinase
HEC99_RS04435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEC99_RS04455	COG3539	Fimbrial protein
HEC99_RS04460	COG3121	Chaperone
HEC99_RS04465	COG3188	usher protein
HEC99_RS04470	COG3539	Fimbrial protein
HEC99_RS04475	COG3956	TIGRFAM MazG family protein
HEC99_RS04490	COG0602	queuosine metabolic process
HEC99_RS04495	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HEC99_RS04495	COG0321	lipoyl(octanoyl) transferase activity
HEC99_RS04500	COG0720	synthase
HEC99_RS04525	COG1203	CRISPR-associated helicase, Cas3
HEC99_RS04540	COG1857	crispr-associated protein
HEC99_RS04555	COG1518	maintenance of DNA repeat elements
HEC99_RS04560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC99_RS04565	COG2234	aminopeptidase activity
HEC99_RS04635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEC99_RS04640	COG0163	prenyltransferase activity
HEC99_RS04650	COG1349	DNA-binding transcription factor activity
HEC99_RS04655	COG2084	Dehydrogenase
HEC99_RS04665	COG0235	Class ii aldolase
HEC99_RS04670	COG3622	Belongs to the hyi family
HEC99_RS04675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC99_RS04680	COG2610	gluconate transmembrane transporter activity
HEC99_RS04690	COG0477	Major facilitator Superfamily
HEC99_RS04755	COG2207	Transcriptional regulator
HEC99_RS04845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEC99_RS04930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC99_RS04935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC99_RS04940	COG1121	(ABC) transporter
HEC99_RS04960	COG0309	Hydrogenase expression formation protein (HypE)
HEC99_RS04965	COG0409	Hydrogenase expression formation protein
HEC99_RS04970	COG0298	carbon dioxide binding
HEC99_RS04975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEC99_RS04990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC99_RS04995	COG0651	ATP synthesis coupled electron transport
HEC99_RS05000	COG0650	Formate hydrogenlyase subunit 4
HEC99_RS05005	COG3261	NADH dehydrogenase
HEC99_RS05005	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HEC99_RS05010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC99_RS05015	COG3260	NADH ubiquinone oxidoreductase 20
HEC99_RS05025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC99_RS05035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC99_RS05040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEC99_RS05060	COG0517	IMP dehydrogenase activity
HEC99_RS05060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HEC99_RS05065	COG1349	DNA-binding transcription factor activity
HEC99_RS05070	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS05085	COG3732	PTS system glucitol sorbitol-specific
HEC99_RS05090	COG3730	PTS system glucitol sorbitol-specific
HEC99_RS05095	COG2951	lytic endotransglycosylase activity
HEC99_RS05100	COG1546	Belongs to the CinA family
HEC99_RS05120	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEC99_RS05150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC99_RS05155	COG1238	metal cluster binding
HEC99_RS05175	COG2814	Major facilitator Superfamily
HEC99_RS05180	COG1566	PFAM secretion protein HlyD family protein
HEC99_RS05185	COG1846	Transcriptional regulator
HEC99_RS05190	COG2814	Major facilitator Superfamily
HEC99_RS05230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC99_RS05240	COG4575	ribosome binding
HEC99_RS05265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC99_RS05270	COG0640	Transcriptional regulator
HEC99_RS05275	COG0401	homolog of Blt101
HEC99_RS05280	COG1652	LysM domain
HEC99_RS05285	COG1802	Transcriptional regulator
HEC99_RS05290	COG1113	amino acid transport
HEC99_RS05295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEC99_RS05300	COG1012	belongs to the aldehyde dehydrogenase family
HEC99_RS05305	COG0579	oxidoreductase
HEC99_RS05335	COG0642	Histidine kinase
HEC99_RS05340	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC99_RS05350	COG2990	Protein conserved in bacteria
HEC99_RS05370	COG2819	hydrolase of the alpha beta superfamily
HEC99_RS05420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC99_RS05445	COG2867	negative regulation of translational initiation
HEC99_RS05460	COG0497	DNA recombination
HEC99_RS05480	COG4536	flavin adenine dinucleotide binding
HEC99_RS05485	COG4137	Cytochrome C assembly protein
HEC99_RS05490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEC99_RS05515	COG2199	diguanylate cyclase activity
HEC99_RS05530	COG0287	Prephenate dehydrogenase
HEC99_RS05530	COG1605	Chorismate mutase
HEC99_RS05540	COG0077	Prephenate dehydratase
HEC99_RS05540	COG1605	Chorismate mutase
HEC99_RS05550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEC99_RS05555	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC99_RS05570	COG0542	response to heat
HEC99_RS05600	COG0477	Major facilitator Superfamily
HEC99_RS05605	COG5544	Lipoprotein
HEC99_RS05610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC99_RS05625	COG3118	belongs to the thioredoxin family
HEC99_RS05630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC99_RS05650	COG0583	DNA-binding transcription factor activity
HEC99_RS05655	COG0513	Belongs to the DEAD box helicase family
HEC99_RS05665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEC99_RS05690	COG3086	response to oxidative stress
HEC99_RS05730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC99_RS05735	COG0583	DNA-binding transcription factor activity
HEC99_RS05740	COG2223	nitrite transmembrane transporter activity
HEC99_RS05745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEC99_RS05750	COG1737	Transcriptional regulator
HEC99_RS05760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC99_RS05760	COG1263	PTS System
HEC99_RS05765	COG0560	Phosphoserine phosphatase
HEC99_RS05790	COG2205	protein histidine kinase activity
HEC99_RS05795	COG3170	Tfp pilus assembly protein FimV
HEC99_RS05800	COG2204	response regulator
HEC99_RS05805	COG0347	Belongs to the P(II) protein family
HEC99_RS05810	COG3104	oligopeptide transport
HEC99_RS05820	COG0531	amino acid
HEC99_RS05825	COG3710	Transcriptional regulator
HEC99_RS05830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC99_RS05830	COG1017	nitric oxide dioxygenase activity
HEC99_RS05840	COG2814	Major facilitator Superfamily
HEC99_RS05845	COG3711	transcriptional antiterminator
HEC99_RS05855	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC99_RS05900	COG0822	iron-sulfur transferase activity
HEC99_RS05920	COG0633	Ferredoxin
HEC99_RS05925	COG2975	iron-sulfur cluster assembly
HEC99_RS05950	COG2897	thiosulfate sulfurtransferase activity
HEC99_RS05955	COG2373	Large extracellular alpha-helical protein
HEC99_RS05960	COG4953	penicillin-binding protein 1C
HEC99_RS05965	COG0243	molybdopterin cofactor binding
HEC99_RS05970	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS06010	COG2976	Protein conserved in bacteria
HEC99_RS06025	COG1645	bacterial-type flagellum-dependent swarming motility
HEC99_RS06065	COG0517	IMP dehydrogenase activity
HEC99_RS06065	COG0516	GMP reductase activity
HEC99_RS06100	COG2200	EAL domain
HEC99_RS06115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEC99_RS06130	COG2233	PERMEase
HEC99_RS06140	COG1393	Belongs to the ArsC family
HEC99_RS06150	COG0628	permease
HEC99_RS06155	COG3835	regulator
HEC99_RS06160	COG2610	gluconate transmembrane transporter activity
HEC99_RS06165	COG1929	Belongs to the glycerate kinase type-1 family
HEC99_RS06170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEC99_RS06175	COG2716	regulation of RNA biosynthetic process
HEC99_RS06180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEC99_RS06185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HEC99_RS06195	COG2321	neutral zinc metallopeptidase
HEC99_RS06215	COG1393	Belongs to the ArsC family
HEC99_RS06225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC99_RS06230	COG3850	Histidine kinase
HEC99_RS06235	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC99_RS06235	COG0493	'glutamate synthase
HEC99_RS06250	COG5342	invasion associated locus B
HEC99_RS06260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEC99_RS06395	COG2837	iron assimilation
HEC99_RS06415	COG4208	sulfate ABC transporter
HEC99_RS06470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS06495	COG3530	Putative quorum-sensing-regulated virulence factor
HEC99_RS06500	COG0385	Bile acid
HEC99_RS06505	COG0583	DNA-binding transcription factor activity
HEC99_RS06515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEC99_RS06520	COG2211	Major facilitator Superfamily
HEC99_RS06530	COG0583	DNA-binding transcription factor activity
HEC99_RS06560	COG3415	Transposase
HEC99_RS06565	COG3415	Transposase
HEC99_RS06580	COG2200	EAL domain
HEC99_RS06580	COG2199	diguanylate cyclase activity
HEC99_RS06585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEC99_RS06600	COG0667	Aldo Keto reductase
HEC99_RS06605	COG3961	Belongs to the TPP enzyme family
HEC99_RS06620	COG0436	Aminotransferase
HEC99_RS06630	COG1560	Kdo2-lipid A biosynthetic process
HEC99_RS06680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEC99_RS06680	COG2755	lipolytic protein G-D-S-L family
HEC99_RS06685	COG0463	Glycosyl transferase, family 2
HEC99_RS06690	COG2246	polysaccharide biosynthetic process
HEC99_RS06705	COG2116	formate transmembrane transporter activity
HEC99_RS06720	COG3691	Protein conserved in bacteria
HEC99_RS06735	COG2062	phosphohistidine phosphatase, SixA
HEC99_RS06760	COG0730	response to heat
HEC99_RS06765	COG3101	peptidyl-lysine hydroxylation
HEC99_RS06780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC99_RS06800	COG3423	Transcriptional regulator
HEC99_RS06825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEC99_RS06835	COG0586	Pfam SNARE associated Golgi protein
HEC99_RS06845	COG0285	dihydrofolate synthase activity
HEC99_RS06850	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HEC99_RS06855	COG1286	toxin biosynthetic process
HEC99_RS06860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HEC99_RS06865	COG3829	transcription factor binding
HEC99_RS06875	COG0531	amino acid
HEC99_RS06880	COG3457	Alanine racemase
HEC99_RS06885	COG0833	amino acid
HEC99_RS06920	COG1090	epimerase
HEC99_RS06925	COG0625	glutathione transferase activity
HEC99_RS06930	COG0625	glutathione transferase activity
HEC99_RS06935	COG0622	Phosphoesterase
HEC99_RS06945	COG1609	Transcriptional regulator
HEC99_RS06950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS06960	COG3037	sugar-specific permease SgaT UlaA
HEC99_RS06965	COG3959	Transketolase, thiamine diphosphate binding domain
HEC99_RS06970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEC99_RS06975	COG1288	antiporter activity
HEC99_RS07000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC99_RS07005	COG0490	domain, Protein
HEC99_RS07005	COG0471	metal ion transport
HEC99_RS07015	COG0436	Aminotransferase
HEC99_RS07020	COG0583	DNA-binding transcription factor activity
HEC99_RS07070	COG0839	Belongs to the complex I subunit 6 family
HEC99_RS07080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEC99_RS07085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC99_RS07100	COG2304	oxidoreductase activity
HEC99_RS07105	COG0835	chemotaxis
HEC99_RS07105	COG0784	Response regulator, receiver
HEC99_RS07115	COG2153	protein acetylation
HEC99_RS07120	COG4575	ribosome binding
HEC99_RS07125	COG1169	isochorismate synthase
HEC99_RS07215	COG1414	Transcriptional regulator
HEC99_RS07245	COG0247	lactate metabolic process
HEC99_RS07255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEC99_RS07260	COG2271	Major facilitator Superfamily
HEC99_RS07265	COG0584	glycerophosphoryl diester phosphodiesterase
HEC99_RS07270	COG0583	DNA-binding transcription factor activity
HEC99_RS07275	COG2814	Major facilitator Superfamily
HEC99_RS07280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC99_RS07310	COG4948	Mandelate Racemase Muconate Lactonizing
HEC99_RS07330	COG0642	Histidine kinase
HEC99_RS07330	COG2198	Histidine kinase
HEC99_RS07355	COG4615	Cyclic peptide transporter
HEC99_RS07365	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC99_RS07365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC99_RS07370	COG3062	negative regulation of establishment of protein localization
HEC99_RS07380	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS07385	COG0348	domain, Protein
HEC99_RS07390	COG3043	anaerobic respiration
HEC99_RS07395	COG3005	denitrification pathway
HEC99_RS07405	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC99_RS07410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC99_RS07415	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC99_RS07425	COG1138	Cytochrome C-type biogenesis protein
HEC99_RS07435	COG3088	subunit of a heme lyase
HEC99_RS07435	COG4235	cytochrome complex assembly
HEC99_RS07440	COG2197	response regulator
HEC99_RS07510	COG1061	Type III restriction enzyme res subunit
HEC99_RS07520	COG2814	Major facilitator Superfamily
HEC99_RS07530	COG4172	Belongs to the ABC transporter superfamily
HEC99_RS07535	COG4239	(ABC) transporter, permease
HEC99_RS07540	COG4174	ABC transporter (Permease)
HEC99_RS07545	COG4166	transmembrane transport
HEC99_RS07550	COG2200	EAL domain
HEC99_RS07555	COG0791	NLP P60 protein
HEC99_RS07560	COG0671	phosphoesterase, PA-phosphatase related
HEC99_RS07565	COG0523	cobalamin synthesis protein
HEC99_RS07600	COG1105	Belongs to the carbohydrate kinase PfkB family
HEC99_RS07605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC99_RS07605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HEC99_RS07605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC99_RS07615	COG2855	membrane
HEC99_RS07620	COG0583	DNA-binding transcription factor activity
HEC99_RS07625	COG0833	amino acid
HEC99_RS07630	COG4771	TonB-dependent receptor
HEC99_RS07635	COG2271	Major facilitator Superfamily
HEC99_RS07640	COG0560	Phosphoserine phosphatase
HEC99_RS07645	COG1760	l-serine dehydratase
HEC99_RS07665	COG2311	Membrane
HEC99_RS07695	COG0493	'glutamate synthase
HEC99_RS07705	COG2949	membrane
HEC99_RS07715	COG1346	cytolysis
HEC99_RS07730	COG2271	Major facilitator Superfamily
HEC99_RS07745	COG0625	glutathione transferase activity
HEC99_RS07750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC99_RS07765	COG1538	Outer membrane efflux protein
HEC99_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS07775	COG0586	Pfam SNARE associated Golgi protein
HEC99_RS07785	COG1686	Belongs to the peptidase S11 family
HEC99_RS07790	COG0277	FAD linked oxidase domain protein
HEC99_RS07800	COG1732	Glycine betaine
HEC99_RS07805	COG1174	glycine betaine transport
HEC99_RS07810	COG1125	glycine betaine transport
HEC99_RS07815	COG1174	glycine betaine transport
HEC99_RS07830	COG3275	phosphorelay sensor kinase activity
HEC99_RS07840	COG4807	Protein conserved in bacteria
HEC99_RS07850	COG4808	Protein conserved in bacteria
HEC99_RS07875	COG3121	Chaperone
HEC99_RS07880	COG3188	usher protein
HEC99_RS07885	COG3539	Fimbrial protein
HEC99_RS07890	COG5455	response to cobalt ion
HEC99_RS07905	COG2188	Transcriptional regulator
HEC99_RS07910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS07915	COG1397	ADP-ribosylglycohydrolase
HEC99_RS07920	COG2211	Major facilitator Superfamily
HEC99_RS07925	COG1830	Aldolase
HEC99_RS07970	COG0745	RESPONSE REGULATOR receiver
HEC99_RS07975	COG2205	protein histidine kinase activity
HEC99_RS08005	COG0443	Heat shock 70 kDa protein
HEC99_RS08010	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEC99_RS08015	COG5001	Diguanylate cyclase
HEC99_RS08015	COG5002	protein histidine kinase activity
HEC99_RS08015	COG3447	MASE1 domain protein
HEC99_RS08030	COG2982	Protein involved in outer membrane biogenesis
HEC99_RS08035	COG1253	flavin adenine dinucleotide binding
HEC99_RS08055	COG0463	Glycosyl transferase, family 2
HEC99_RS08060	COG1045	serine acetyltransferase
HEC99_RS08065	COG0438	transferase activity, transferring glycosyl groups
HEC99_RS08075	COG1216	Glycosyl transferase, family 2
HEC99_RS08080	COG0110	maltose O-acetyltransferase activity
HEC99_RS08085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEC99_RS08090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC99_RS08100	COG0297	glycogen (starch) synthase activity
HEC99_RS08115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEC99_RS08120	COG2244	polysaccharide biosynthetic process
HEC99_RS08125	COG2327	Polysaccharide pyruvyl transferase
HEC99_RS08170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEC99_RS08185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC99_RS08190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC99_RS08195	COG2244	polysaccharide biosynthetic process
HEC99_RS08290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC99_RS08295	COG0583	DNA-binding transcription factor activity
HEC99_RS08305	COG0531	amino acid
HEC99_RS08310	COG2925	Exonuclease
HEC99_RS08350	COG1289	transmembrane transporter activity
HEC99_RS08385	COG4656	Part of a membrane complex involved in electron transport
HEC99_RS08390	COG1012	belongs to the aldehyde dehydrogenase family
HEC99_RS08390	COG1454	alcohol dehydrogenase
HEC99_RS08420	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEC99_RS08550	COG1122	ATPase activity
HEC99_RS08585	COG0534	Mate efflux family protein
HEC99_RS08610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEC99_RS08785	COG0582	viral genome integration into host DNA
HEC99_RS08855	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HEC99_RS08870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEC99_RS08890	COG3646	Phage regulatory protein
HEC99_RS08910	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HEC99_RS08915	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HEC99_RS08925	COG1403	HNH endonuclease
HEC99_RS08930	COG0484	heat shock protein binding
HEC99_RS08955	COG3179	chitinase
HEC99_RS08975	COG4626	Terminase
HEC99_RS08975	COG1802	Transcriptional regulator
HEC99_RS09025	COG4386	tail sheath protein
HEC99_RS09065	COG3299	homolog of phage Mu protein gp47
HEC99_RS09070	COG3778	Protein conserved in bacteria
HEC99_RS09090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HEC99_RS09110	COG3547	Transposase (IS116 IS110 IS902 family)
HEC99_RS09145	COG3381	protein complex oligomerization
HEC99_RS09200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC99_RS09220	COG5645	(Lipo)protein
HEC99_RS09235	COG1560	Kdo2-lipid A biosynthetic process
HEC99_RS09250	COG3038	cytochrome b561
HEC99_RS09285	COG2999	glutathione oxidoreductase activity
HEC99_RS09295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC99_RS09385	COG1530	ribonuclease E activity
HEC99_RS09445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC99_RS09450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEC99_RS09455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEC99_RS09465	COG0470	DNA polymerase III
HEC99_RS09470	COG0084	hydrolase, TatD family'
HEC99_RS09480	COG4773	Receptor
HEC99_RS09485	COG0537	adenosine 5'-monophosphoramidase activity
HEC99_RS09490	COG5633	Lipoprotein
HEC99_RS09515	COG1252	NADH dehydrogenase
HEC99_RS09520	COG3134	Outer membrane lipoprotein
HEC99_RS09525	COG1309	transcriptional regulator
HEC99_RS09535	COG1388	LysM domain
HEC99_RS09535	COG1376	ErfK ybiS ycfS ynhG family protein
HEC99_RS09540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEC99_RS09545	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEC99_RS09550	COG1136	(ABC) transporter
HEC99_RS09555	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEC99_RS09575	COG1177	transmembrane transport
HEC99_RS09605	COG2850	peptidyl-arginine hydroxylation
HEC99_RS09620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEC99_RS09650	COG0538	isocitrate dehydrogenase activity
HEC99_RS09705	COG0071	Belongs to the small heat shock protein (HSP20) family
HEC99_RS09715	COG3038	cytochrome b561
HEC99_RS09745	COG1124	(ABC) transporter
HEC99_RS09750	COG0668	transmembrane transport
HEC99_RS09765	COG3443	Belongs to the bacterial solute-binding protein 9 family
HEC99_RS09780	COG0789	Transcriptional regulator
HEC99_RS09790	COG1605	Chorismate mutase
HEC99_RS09800	COG3615	Tellurite resistance protein tehB
HEC99_RS09815	COG2261	transglycosylase associated protein
HEC99_RS09825	COG3042	response to heat
HEC99_RS09835	COG3189	MarR family transcriptional regulator
HEC99_RS09840	COG2807	transmembrane transport
HEC99_RS09845	COG2207	Transcriptional regulator
HEC99_RS09860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC99_RS09865	COG2199	diguanylate cyclase activity
HEC99_RS09880	COG2766	serine protein kinase
HEC99_RS09885	COG3713	MltA-interacting MipA family protein
HEC99_RS09890	COG0641	radical SAM
HEC99_RS09895	COG0656	L-ascorbic acid biosynthetic process
HEC99_RS09915	COG3139	Protein of unknown function (DUF1315)
HEC99_RS09925	COG2271	Major facilitator Superfamily
HEC99_RS09930	COG1063	alcohol dehydrogenase
HEC99_RS09935	COG0191	fructose-bisphosphate aldolase activity
HEC99_RS09940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS09945	COG0667	Aldo Keto reductase
HEC99_RS09950	COG1349	DNA-binding transcription factor activity
HEC99_RS09955	COG2814	Major facilitator Superfamily
HEC99_RS09960	COG1335	isochorismatase
HEC99_RS09965	COG0252	asparaginase activity
HEC99_RS09970	COG0616	signal peptide processing
HEC99_RS09975	COG0778	Nitroreductase
HEC99_RS09985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEC99_RS10000	COG0494	nUDIX hydrolase
HEC99_RS10040	COG3678	ATP-independent chaperone mediated protein folding
HEC99_RS10045	COG0322	excinuclease ABC activity
HEC99_RS10055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC99_RS10060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC99_RS10065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC99_RS10070	COG1447	Phosphotransferase system cellobiose-specific component IIA
HEC99_RS10075	COG2169	Transcriptional regulator
HEC99_RS10075	COG1917	Cupin 2, conserved barrel domain protein
HEC99_RS10080	COG1486	melibiose metabolic process
HEC99_RS10090	COG0753	catalase activity
HEC99_RS10105	COG1988	membrane-bound metal-dependent
HEC99_RS10110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC99_RS10120	COG3001	Fructosamine kinase
HEC99_RS10130	COG1105	Belongs to the carbohydrate kinase PfkB family
HEC99_RS10135	COG3137	Salt-induced outer membrane protein
HEC99_RS10210	COG0386	Belongs to the glutathione peroxidase family
HEC99_RS10220	COG0791	NLP P60 protein
HEC99_RS10235	COG4256	Hemin uptake protein
HEC99_RS10250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEC99_RS10250	COG0574	Belongs to the PEP-utilizing enzyme family
HEC99_RS10255	COG0318	PFAM AMP-dependent synthetase and ligase
HEC99_RS10260	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HEC99_RS10265	COG0644	oxidoreductase
HEC99_RS10270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEC99_RS10275	COG2086	electron transfer activity
HEC99_RS10280	COG1917	Cupin 2, conserved barrel domain protein
HEC99_RS10280	COG2207	Transcriptional regulator
HEC99_RS10285	COG1960	acyl-CoA dehydrogenase activity
HEC99_RS10290	COG4670	ketone body catabolic process
HEC99_RS10305	COG2271	Major facilitator Superfamily
HEC99_RS10310	COG0738	Major facilitator superfamily
HEC99_RS10325	COG0628	permease
HEC99_RS10330	COG0277	FAD linked oxidase domain protein
HEC99_RS10330	COG0247	lactate metabolic process
HEC99_RS10335	COG2050	protein possibly involved in aromatic compounds catabolism
HEC99_RS10350	COG0316	Belongs to the HesB IscA family
HEC99_RS10355	COG0719	Fe-S assembly protein
HEC99_RS10360	COG0396	ATPase activity
HEC99_RS10365	COG0719	Fe-S assembly protein
HEC99_RS10380	COG1376	ErfK ybiS ycfS ynhG family protein
HEC99_RS10400	COG0531	amino acid
HEC99_RS10405	COG2267	carboxylic ester hydrolase activity
HEC99_RS10415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS10450	COG3272	Protein of unknown function (DUF1722)
HEC99_RS10455	COG0789	Transcriptional regulator
HEC99_RS10635	COG0307	riboflavin synthase, alpha
HEC99_RS10640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEC99_RS10645	COG2814	Major facilitator Superfamily
HEC99_RS10650	COG0583	DNA-binding transcription factor activity
HEC99_RS10670	COG0791	NLP P60 protein
HEC99_RS10675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEC99_RS10690	COG1902	pentaerythritol trinitrate reductase activity
HEC99_RS10695	COG1309	transcriptional regulator
HEC99_RS10700	COG3313	Fe-S protein
HEC99_RS10705	COG4989	oxidoreductase activity
HEC99_RS10720	COG1566	PFAM secretion protein HlyD family protein
HEC99_RS10745	COG3895	Periplasmic Protein
HEC99_RS10765	COG0625	glutathione transferase activity
HEC99_RS10775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEC99_RS10825	COG0673	inositol 2-dehydrogenase activity
HEC99_RS10845	COG5339	Protein conserved in bacteria
HEC99_RS10870	COG2205	protein histidine kinase activity
HEC99_RS10875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HEC99_RS10880	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC99_RS10885	COG0745	RESPONSE REGULATOR receiver
HEC99_RS10890	COG3136	membrane protein required for alginate biosynthesis
HEC99_RS10895	COG0531	amino acid
HEC99_RS10905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HEC99_RS10910	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HEC99_RS10915	COG0628	permease
HEC99_RS10930	COG3591	Belongs to the peptidase S1B family
HEC99_RS10940	COG2814	Major facilitator Superfamily
HEC99_RS10945	COG0583	DNA-binding transcription factor activity
HEC99_RS10950	COG1940	carbohydrate kinase activity
HEC99_RS10990	COG3302	dmso reductase anchor subunit
HEC99_RS10995	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS11000	COG0243	molybdopterin cofactor binding
HEC99_RS11005	COG0243	molybdopterin cofactor binding
HEC99_RS11020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC99_RS11040	COG1063	alcohol dehydrogenase
HEC99_RS11045	COG0477	Major facilitator Superfamily
HEC99_RS11050	COG0246	Mannitol dehydrogenase
HEC99_RS11060	COG1802	Transcriptional regulator
HEC99_RS11065	COG4221	oxidoreductase activity
HEC99_RS11075	COG3729	General stress protein
HEC99_RS11080	COG1546	Belongs to the CinA family
HEC99_RS11085	COG3111	PFAM Bacterial OB fold (BOF) protein
HEC99_RS11095	COG2814	Major facilitator Superfamily
HEC99_RS11130	COG0583	DNA-binding transcription factor activity
HEC99_RS11135	COG1012	belongs to the aldehyde dehydrogenase family
HEC99_RS11150	COG3781	membrane
HEC99_RS11175	COG1773	rubredoxin
HEC99_RS11200	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEC99_RS11205	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HEC99_RS11215	COG2186	Transcriptional regulator
HEC99_RS11220	COG1063	alcohol dehydrogenase
HEC99_RS11225	COG2271	Major facilitator Superfamily
HEC99_RS11250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEC99_RS11255	COG0251	oxidation-reduction process
HEC99_RS11270	COG1609	Transcriptional regulator
HEC99_RS11275	COG1757	Na H antiporter
HEC99_RS11280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HEC99_RS11295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEC99_RS11310	COG1764	response to oxidative stress
HEC99_RS11330	COG1064	alcohol dehydrogenase
HEC99_RS11335	COG2864	formate dehydrogenase
HEC99_RS11340	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS11380	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HEC99_RS11385	COG1140	nitrate reductase beta subunit
HEC99_RS11390	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HEC99_RS11395	COG2181	nitrate reductase activity
HEC99_RS11430	COG4772	TonB-dependent receptor
HEC99_RS11435	COG1802	Transcriptional regulator
HEC99_RS11440	COG2130	NADP-dependent
HEC99_RS11450	COG3238	Protein conserved in bacteria
HEC99_RS11490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEC99_RS11495	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEC99_RS11520	COG0826	peptidase U32
HEC99_RS11525	COG1396	sequence-specific DNA binding
HEC99_RS11530	COG3135	benzoate transporter
HEC99_RS11540	COG0500	methyltransferase
HEC99_RS11545	COG1275	C4-dicarboxylate transporter malic acid transport protein
HEC99_RS11550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC99_RS11555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC99_RS11565	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC99_RS11570	COG3775	system Galactitol-specific IIC component
HEC99_RS11575	COG0434	BtpA family
HEC99_RS11580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS11585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEC99_RS11590	COG1349	DNA-binding transcription factor activity
HEC99_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS11610	COG2271	Major facilitator Superfamily
HEC99_RS11615	COG1063	alcohol dehydrogenase
HEC99_RS11625	COG2353	YceI-like domain
HEC99_RS11635	COG2272	Belongs to the type-B carboxylesterase lipase family
HEC99_RS11640	COG5383	Protein conserved in bacteria
HEC99_RS11645	COG0583	DNA-binding transcription factor activity
HEC99_RS11650	COG0840	transmembrane signaling receptor activity
HEC99_RS11685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC99_RS11690	COG0765	amino acid transport
HEC99_RS11700	COG0765	amino acid transport
HEC99_RS11710	COG0500	methyltransferase
HEC99_RS11715	COG3038	cytochrome b561
HEC99_RS11720	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEC99_RS11725	COG1643	Atp-dependent helicase
HEC99_RS11740	COG3784	Protein of unknown function (DUF1318)
HEC99_RS11750	COG2911	Protein conserved in bacteria
HEC99_RS11755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEC99_RS11760	COG3187	Heat shock protein
HEC99_RS11765	COG3042	response to heat
HEC99_RS11775	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEC99_RS11775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC99_RS11775	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEC99_RS11775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEC99_RS11785	COG2076	Multidrug Resistance protein
HEC99_RS11905	COG0513	Belongs to the DEAD box helicase family
HEC99_RS11915	COG0840	transmembrane signaling receptor activity
HEC99_RS11920	COG2840	Smr protein MutS2
HEC99_RS11940	COG3182	Iron-regulated membrane protein
HEC99_RS11945	COG0668	transmembrane transport
HEC99_RS11965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HEC99_RS12000	COG1309	transcriptional regulator
HEC99_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS12010	COG0656	L-ascorbic acid biosynthetic process
HEC99_RS12015	COG0583	DNA-binding transcription factor activity
HEC99_RS12025	COG4166	transmembrane transport
HEC99_RS12030	COG2866	Carboxypeptidase
HEC99_RS12035	COG4948	Mandelate Racemase Muconate Lactonizing
HEC99_RS12055	COG3106	COG3106 Predicted ATPase
HEC99_RS12060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC99_RS12070	COG1983	PspC domain protein
HEC99_RS12080	COG1842	Phage shock protein A
HEC99_RS12085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HEC99_RS12135	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC99_RS12135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC99_RS12145	COG5001	Diguanylate cyclase
HEC99_RS12155	COG1349	DNA-binding transcription factor activity
HEC99_RS12175	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEC99_RS12180	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HEC99_RS12185	COG0671	phosphoesterase, PA-phosphatase related
HEC99_RS12225	COG0616	signal peptide processing
HEC99_RS12230	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS12245	COG0009	L-threonylcarbamoyladenylate synthase
HEC99_RS12270	COG0134	indole-3-glycerol-phosphate synthase activity
HEC99_RS12270	COG0135	phosphoribosylanthranilate isomerase activity
HEC99_RS12285	COG3729	General stress protein
HEC99_RS12290	COG3685	Protein conserved in bacteria
HEC99_RS12295	COG3685	Protein conserved in bacteria
HEC99_RS12300	COG3546	catalase activity
HEC99_RS12310	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEC99_RS12335	COG2350	Protein conserved in bacteria
HEC99_RS12355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEC99_RS12385	COG2095	MarC family integral membrane protein
HEC99_RS12390	COG1454	alcohol dehydrogenase
HEC99_RS12390	COG1012	belongs to the aldehyde dehydrogenase family
HEC99_RS12405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEC99_RS12410	COG0745	RESPONSE REGULATOR receiver
HEC99_RS12415	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEC99_RS12425	COG0788	formyltetrahydrofolate deformylase activity
HEC99_RS12470	COG2181	nitrate reductase activity
HEC99_RS12475	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HEC99_RS12480	COG1140	nitrate reductase beta subunit
HEC99_RS12485	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HEC99_RS12490	COG2223	nitrite transmembrane transporter activity
HEC99_RS12495	COG3850	Histidine kinase
HEC99_RS12500	COG2197	response regulator
HEC99_RS12505	COG4932	domain protein
HEC99_RS12510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HEC99_RS12515	COG4572	Cation transport regulator
HEC99_RS12520	COG0387	Pfam Sodium calcium exchanger
HEC99_RS12570	COG0659	secondary active sulfate transmembrane transporter activity
HEC99_RS12585	COG0012	GTP binding
HEC99_RS12600	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HEC99_RS12610	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HEC99_RS12615	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC99_RS12620	COG1999	signal sequence binding
HEC99_RS12625	COG1773	rubredoxin
HEC99_RS12630	COG1271	oxidase subunit
HEC99_RS12635	COG1294	oxidase, subunit
HEC99_RS12645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEC99_RS12670	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEC99_RS12690	COG2719	SpoVR family
HEC99_RS12730	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEC99_RS12745	COG2894	cell division
HEC99_RS12755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEC99_RS12765	COG3065	identical protein binding
HEC99_RS12775	COG1199	ATP-dependent helicase activity
HEC99_RS12780	COG0251	oxidation-reduction process
HEC99_RS12800	COG1760	l-serine dehydratase
HEC99_RS12805	COG2200	EAL domain
HEC99_RS12810	COG1253	flavin adenine dinucleotide binding
HEC99_RS12815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC99_RS12815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS12820	COG3715	PTS system
HEC99_RS12825	COG3716	PTS system mannose fructose sorbose family IID component
HEC99_RS12840	COG2226	methyltransferase
HEC99_RS12845	COG0768	penicillin binding
HEC99_RS12875	COG1414	Transcriptional regulator
HEC99_RS12880	COG2814	Major facilitator Superfamily
HEC99_RS12900	COG1956	GAF domain-containing protein
HEC99_RS12905	COG2995	paraquat-inducible protein a
HEC99_RS12910	COG3008	intermembrane lipid transfer
HEC99_RS12945	COG5562	phage envelope protein
HEC99_RS12955	COG0454	-acetyltransferase
HEC99_RS13055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC99_RS13175	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HEC99_RS13195	COG1276	copper resistance
HEC99_RS13200	COG2372	response to copper ion
HEC99_RS13210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC99_RS13215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC99_RS13220	COG1770	oligopeptidase
HEC99_RS13225	COG2979	Protein of unknown function (DUF533)
HEC99_RS13235	COG3141	response to X-ray
HEC99_RS13245	COG0800	Aldolase
HEC99_RS13250	COG0129	dihydroxy-acid dehydratase activity
HEC99_RS13255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEC99_RS13260	COG1737	Transcriptional regulator
HEC99_RS13270	COG1560	Kdo2-lipid A biosynthetic process
HEC99_RS13275	COG0739	heme binding
HEC99_RS13280	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HEC99_RS13290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC99_RS13325	COG0494	nUDIX hydrolase
HEC99_RS13335	COG1335	isochorismatase
HEC99_RS13340	COG1801	Protein of unknown function DUF72
HEC99_RS13345	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HEC99_RS13365	COG3102	Protein conserved in bacteria
HEC99_RS13380	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HEC99_RS13485	COG1528	Iron-storage protein
HEC99_RS13500	COG1528	Iron-storage protein
HEC99_RS13510	COG0814	amino acid
HEC99_RS13515	COG3318	Belongs to the UPF0149 family
HEC99_RS13515	COG3012	SEC-C Motif Domain Protein
HEC99_RS13560	COG2197	response regulator
HEC99_RS13575	COG2197	response regulator
HEC99_RS13655	COG0425	Belongs to the sulfur carrier protein TusA family
HEC99_RS13760	COG5475	Uncharacterized small protein (DUF2158)
HEC99_RS13765	COG2354	Protein conserved in bacteria
HEC99_RS13770	COG0697	spore germination
HEC99_RS13775	COG3727	T/G mismatch-specific endonuclease activity
HEC99_RS13780	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEC99_RS13785	COG1418	mRNA catabolic process
HEC99_RS13795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC99_RS13840	COG3209	COG3209 Rhs family protein
HEC99_RS13865	COG3157	Type VI secretion system effector, Hcp
HEC99_RS13900	COG0673	inositol 2-dehydrogenase activity
HEC99_RS13905	COG2814	Major facilitator Superfamily
HEC99_RS13925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEC99_RS13930	COG1737	Transcriptional regulator
HEC99_RS13935	COG1702	phosphate starvation-inducible protein PhoH
HEC99_RS13955	COG1309	transcriptional regulator
HEC99_RS13960	COG3729	General stress protein
HEC99_RS13980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEC99_RS13985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEC99_RS13985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEC99_RS13990	COG4232	protein-disulfide reductase activity
HEC99_RS14035	COG3971	2-oxopent-4-enoate hydratase activity
HEC99_RS14045	COG3384	dioxygenase
HEC99_RS14050	COG1012	belongs to the aldehyde dehydrogenase family
HEC99_RS14060	COG1846	Transcriptional regulator
HEC99_RS14065	COG2368	4-hydroxyphenylacetate
HEC99_RS14080	COG0745	RESPONSE REGULATOR receiver
HEC99_RS14085	COG2205	protein histidine kinase activity
HEC99_RS14135	COG0670	Belongs to the BI1 family
HEC99_RS14155	COG1881	PFAM PEBP family protein
HEC99_RS14170	COG1832	CoA-binding protein
HEC99_RS14185	COG0210	DNA helicase
HEC99_RS14190	COG3304	Inner membrane component domain
HEC99_RS14195	COG1289	transmembrane transporter activity
HEC99_RS14200	COG3070	regulator of competence-specific genes
HEC99_RS14220	COG1067	ATP-dependent peptidase activity
HEC99_RS14230	COG3130	regulation of translation
HEC99_RS14235	COG3009	Protein conserved in bacteria
HEC99_RS14240	COG3008	intermembrane lipid transfer
HEC99_RS14240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEC99_RS14245	COG2995	paraquat-inducible protein a
HEC99_RS14250	COG0488	(ABC) transporter
HEC99_RS14260	COG0633	Ferredoxin
HEC99_RS14260	COG3217	Mosc domain protein beta barrel domain protein
HEC99_RS14275	COG0308	aminopeptidase N
HEC99_RS14295	COG2135	peptidase activity
HEC99_RS14325	COG5301	cellulose 1,4-beta-cellobiosidase activity
HEC99_RS14340	COG0582	viral genome integration into host DNA
HEC99_RS14350	COG1115	amino acid carrier protein
HEC99_RS14360	COG1522	sequence-specific DNA binding
HEC99_RS14365	COG0017	Asparaginyl-tRNA synthetase
HEC99_RS14370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC99_RS14380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEC99_RS14385	COG3108	Peptidase M15
HEC99_RS14390	COG2989	Protein conserved in bacteria
HEC99_RS14400	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HEC99_RS14410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEC99_RS14415	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEC99_RS14420	COG3173	Aminoglycoside phosphotransferase
HEC99_RS14435	COG3214	Protein conserved in bacteria
HEC99_RS14450	COG2333	competence protein COMEC
HEC99_RS14450	COG0658	competence protein
HEC99_RS14460	COG0539	negative regulation of cytoplasmic translation
HEC99_RS14470	COG0501	Belongs to the peptidase M48B family
HEC99_RS14485	COG2323	membrane
HEC99_RS14490	COG1944	ATP diphosphatase activity
HEC99_RS14495	COG2116	formate transmembrane transporter activity
HEC99_RS14500	COG1882	Formate acetyltransferase
HEC99_RS14515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC99_RS14520	COG0531	amino acid
HEC99_RS14530	COG3302	dmso reductase anchor subunit
HEC99_RS14535	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS14540	COG0243	molybdopterin cofactor binding
HEC99_RS14550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEC99_RS14570	COG0492	ferredoxin-NADP+ reductase activity
HEC99_RS14575	COG4988	ABC transporter
HEC99_RS14580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEC99_RS14600	COG0583	DNA-binding transcription factor activity
HEC99_RS14610	COG1335	isochorismatase
HEC99_RS14630	COG0542	response to heat
HEC99_RS14640	COG1278	Cold shock
HEC99_RS14645	COG1136	(ABC) transporter
HEC99_RS14645	COG0577	efflux transmembrane transporter activity
HEC99_RS14650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC99_RS14655	COG2990	Protein conserved in bacteria
HEC99_RS14660	COG3593	DNA synthesis involved in DNA repair
HEC99_RS14665	COG2431	L-lysine efflux transmembrane transporter activity
HEC99_RS14675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC99_RS14680	COG0028	Belongs to the TPP enzyme family
HEC99_RS14685	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HEC99_RS14690	COG0702	epimerase
HEC99_RS14695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC99_RS14700	COG3023	N-Acetylmuramoyl-L-alanine amidase
HEC99_RS14715	COG1126	abc transporter atp-binding protein
HEC99_RS14720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC99_RS14725	COG4215	(ABC) transporter
HEC99_RS14730	COG4160	amino acid transport
HEC99_RS14735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC99_RS14765	COG1177	transmembrane transport
HEC99_RS14770	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEC99_RS14775	COG3842	ATPase activity
HEC99_RS14780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEC99_RS14820	COG3226	Transcriptional regulator
HEC99_RS14825	COG0738	Major facilitator superfamily
HEC99_RS14830	COG0561	phosphatase activity
HEC99_RS14835	COG2814	Major facilitator Superfamily
HEC99_RS14840	COG0671	phosphoesterase, PA-phosphatase related
HEC99_RS14845	COG1349	DNA-binding transcription factor activity
HEC99_RS14850	COG1686	Belongs to the peptidase S11 family
HEC99_RS14855	COG0625	glutathione transferase activity
HEC99_RS14860	COG2133	pyrroloquinoline quinone binding
HEC99_RS14870	COG2610	gluconate transmembrane transporter activity
HEC99_RS14875	COG0583	DNA-binding transcription factor activity
HEC99_RS14885	COG1960	acyl-CoA dehydrogenase activity
HEC99_RS14890	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HEC99_RS14905	COG2301	Belongs to the HpcH HpaI aldolase family
HEC99_RS14930	COG0747	negative chemotaxis
HEC99_RS14955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC99_RS14960	COG1882	Formate acetyltransferase
HEC99_RS14965	COG0561	phosphatase activity
HEC99_RS14985	COG0488	(ABC) transporter
HEC99_RS14990	COG1376	ErfK ybiS ycfS ynhG family protein
HEC99_RS14995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HEC99_RS15010	COG2194	sulfuric ester hydrolase activity
HEC99_RS15015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HEC99_RS15030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC99_RS15035	COG0765	amino acid transport
HEC99_RS15040	COG1126	abc transporter atp-binding protein
HEC99_RS15045	COG0668	transmembrane transport
HEC99_RS15055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEC99_RS15065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEC99_RS15075	COG0513	Belongs to the DEAD box helicase family
HEC99_RS15080	COG1309	transcriptional regulator
HEC99_RS15090	COG1131	(ABC) transporter
HEC99_RS15095	COG0842	Transport permease protein
HEC99_RS15100	COG0842	Transport permease protein
HEC99_RS15110	COG3568	Endonuclease Exonuclease Phosphatase
HEC99_RS15115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC99_RS15120	COG0392	lysyltransferase activity
HEC99_RS15140	COG0670	Belongs to the BI1 family
HEC99_RS15150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEC99_RS15160	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEC99_RS15190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEC99_RS15215	COG1881	PFAM PEBP family protein
HEC99_RS15245	COG4677	pectinesterase activity
HEC99_RS15255	COG0561	phosphatase activity
HEC99_RS15265	COG4149	molybdate abc transporter
HEC99_RS15270	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEC99_RS15280	COG2005	Transcriptional regulator
HEC99_RS15280	COG3585	molybdate ion transport
HEC99_RS15285	COG1119	ATPase activity
HEC99_RS15310	COG2017	converts alpha-aldose to the beta-anomer
HEC99_RS15320	COG1120	ATPase activity
HEC99_RS15325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC99_RS15355	COG0583	DNA-binding transcription factor activity
HEC99_RS15360	COG0583	DNA-binding transcription factor activity
HEC99_RS15365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC99_RS15370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC99_RS15370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC99_RS15375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEC99_RS15385	COG1230	cation diffusion facilitator family transporter
HEC99_RS15435	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HEC99_RS15440	COG2885	chlorophyll binding
HEC99_RS15450	COG3064	Membrane
HEC99_RS15455	COG0848	biopolymer transport protein
HEC99_RS15460	COG0811	peptide transport
HEC99_RS15465	COG0824	Thioesterase
HEC99_RS15470	COG3790	cyd operon protein YbgE
HEC99_RS15475	COG4890	Cyd operon protein YbgT
HEC99_RS15480	COG1294	oxidase, subunit
HEC99_RS15485	COG1271	oxidase subunit
HEC99_RS15490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC99_RS15500	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEC99_RS15505	COG0567	Dehydrogenase, E1 component
HEC99_RS15520	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEC99_RS15540	COG3180	Ammonia monooxygenase
HEC99_RS15555	COG1984	allophanate hydrolase subunit 2
HEC99_RS15560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HEC99_RS15605	COG2205	protein histidine kinase activity
HEC99_RS15610	COG0745	RESPONSE REGULATOR receiver
HEC99_RS15620	COG1982	Orn Lys Arg decarboxylase major
HEC99_RS15625	COG0531	amino acid
HEC99_RS15635	COG0033	Phosphoglucomutase
HEC99_RS15645	COG0596	Alpha beta hydrolase
HEC99_RS15660	COG0735	belongs to the Fur family
HEC99_RS15665	COG0583	DNA-binding transcription factor activity
HEC99_RS15670	COG1053	succinate dehydrogenase
HEC99_RS15710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEC99_RS15715	COG1846	Transcriptional regulator
HEC99_RS15715	COG1940	carbohydrate kinase activity
HEC99_RS15720	COG0647	UMP catabolic process
HEC99_RS15725	COG0367	asparagine synthase
HEC99_RS15765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC99_RS15775	COG1702	phosphate starvation-inducible protein PhoH
HEC99_RS15800	COG0765	amino acid transport
HEC99_RS15805	COG0765	amino acid transport
HEC99_RS15810	COG1126	abc transporter atp-binding protein
HEC99_RS15830	COG0443	Heat shock 70 kDa protein
HEC99_RS15835	COG2214	Heat shock protein DnaJ domain protein
HEC99_RS15845	COG2214	Heat shock protein DnaJ domain protein
HEC99_RS15860	COG2888	peptidyl-tyrosine sulfation
HEC99_RS15865	COG3829	transcription factor binding
HEC99_RS15865	COG3290	protein histidine kinase activity
HEC99_RS15895	COG1466	dna polymerase III delta subunit
HEC99_RS15915	COG0799	negative regulation of ribosome biogenesis
HEC99_RS15925	COG0768	penicillin binding
HEC99_RS15930	COG0772	Belongs to the SEDS family
HEC99_RS15940	COG1686	Belongs to the peptidase S11 family
HEC99_RS15955	COG0583	DNA-binding transcription factor activity
HEC99_RS15970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC99_RS15990	COG3069	C4-dicarboxylate transmembrane transporter activity
HEC99_RS15995	COG4565	transcriptional regulatory protein
HEC99_RS16000	COG3290	protein histidine kinase activity
HEC99_RS16005	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HEC99_RS16015	COG2301	Belongs to the HpcH HpaI aldolase family
HEC99_RS16020	COG3051	citrate lyase alpha subunit
HEC99_RS16035	COG0471	metal ion transport
HEC99_RS16040	COG3719	Belongs to the RNase T2 family
HEC99_RS16045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEC99_RS16050	COG1063	alcohol dehydrogenase
HEC99_RS16070	COG0243	molybdopterin cofactor binding
HEC99_RS16090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEC99_RS16095	COG0583	DNA-binding transcription factor activity
HEC99_RS16100	COG3969	phosphoadenosine phosphosulfate
HEC99_RS16105	COG1475	DNA binding
HEC99_RS16110	COG0436	Aminotransferase
HEC99_RS16115	COG0371	Dehydrogenase
HEC99_RS16120	COG2879	small protein
HEC99_RS16125	COG1966	Carbon starvation protein
HEC99_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS16140	COG3433	isochorismatase activity
HEC99_RS16140	COG1535	isochorismatase
HEC99_RS16145	COG1021	2,3-dihydroxybenzoate-AMP ligase
HEC99_RS16150	COG1169	isochorismate synthase
HEC99_RS16155	COG4592	Periplasmic binding protein
HEC99_RS16165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC99_RS16170	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC99_RS16175	COG1120	ATPase activity
HEC99_RS16180	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HEC99_RS16185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HEC99_RS16185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEC99_RS16190	COG3251	PFAM MbtH domain protein
HEC99_RS16195	COG2382	esterase
HEC99_RS16200	COG4771	TonB-dependent receptor
HEC99_RS16230	COG2315	Protein conserved in bacteria
HEC99_RS16245	COG0668	transmembrane transport
HEC99_RS16250	COG1113	amino acid transport
HEC99_RS16260	COG3059	membrane
HEC99_RS16270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC99_RS16275	COG2207	Transcriptional regulator
HEC99_RS16295	COG2246	polysaccharide biosynthetic process
HEC99_RS16300	COG0463	Glycosyl transferase, family 2
HEC99_RS16375	COG2501	S4 domain
HEC99_RS16380	COG1988	membrane-bound metal-dependent
HEC99_RS16400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEC99_RS16410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEC99_RS16415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HEC99_RS16420	COG0549	Belongs to the carbamate kinase family
HEC99_RS16430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC99_RS16435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC99_RS16440	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HEC99_RS16445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEC99_RS16450	COG3257	ureidoglycine aminohydrolase activity
HEC99_RS16455	COG1929	Belongs to the glycerate kinase type-1 family
HEC99_RS16460	COG2233	PERMEase
HEC99_RS16470	COG1953	Uracil, thiamine, allantoin
HEC99_RS16480	COG2084	Dehydrogenase
HEC99_RS16485	COG3622	Belongs to the hyi family
HEC99_RS16490	COG3960	tartronate-semialdehyde synthase activity
HEC99_RS16525	COG1464	Belongs to the NlpA lipoprotein family
HEC99_RS16535	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEC99_RS16540	COG4181	ATPase activity
HEC99_RS16545	COG2755	lipolytic protein G-D-S-L family
HEC99_RS16550	COG0300	oxidoreductase activity
HEC99_RS16555	COG3118	belongs to the thioredoxin family
HEC99_RS16560	COG0390	transport system, permease component
HEC99_RS16565	COG4619	ABC transporter
HEC99_RS16570	COG0330	HflC and HflK could
HEC99_RS16575	COG1585	Membrane protein implicated in regulation of membrane protease activity
HEC99_RS16585	COG2217	Heavy metal translocating P-type atpase
HEC99_RS16595	COG3735	TraB family
HEC99_RS16610	COG2223	nitrite transmembrane transporter activity
HEC99_RS16615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEC99_RS16615	COG4651	solute:proton antiporter activity
HEC99_RS16620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS16665	COG2832	Protein of unknown function (DUF454)
HEC99_RS16670	COG3923	Primosomal replication protein n
HEC99_RS16680	COG5464	transposase or invertase
HEC99_RS16685	COG3264	Mechanosensitive ion channel
HEC99_RS16685	COG1196	nuclear chromosome segregation
HEC99_RS16690	COG1309	transcriptional regulator
HEC99_RS16695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC99_RS16700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC99_RS16715	COG0110	maltose O-acetyltransferase activity
HEC99_RS16735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HEC99_RS16745	COG3695	enzyme binding
HEC99_RS16750	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HEC99_RS16755	COG1946	Acyl-CoA thioesterase
HEC99_RS16760	COG0004	ammonium transporteR
HEC99_RS16765	COG0347	Belongs to the P(II) protein family
HEC99_RS16770	COG1132	(ABC) transporter
HEC99_RS16775	COG1132	(ABC) transporter
HEC99_RS16780	COG1522	sequence-specific DNA binding
HEC99_RS16795	COG4533	DNA binding
HEC99_RS16805	COG0824	Thioesterase
HEC99_RS16810	COG1555	photosystem II stabilization
HEC99_RS16815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEC99_RS16825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEC99_RS16845	COG0271	Belongs to the BolA IbaG family
HEC99_RS16850	COG3056	Lipoprotein
HEC99_RS16855	COG2223	nitrite transmembrane transporter activity
HEC99_RS16860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEC99_RS16865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEC99_RS16870	COG1845	cytochrome c oxidase, subunit III
HEC99_RS16875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEC99_RS16895	COG2814	Major facilitator Superfamily
HEC99_RS16925	COG2188	Transcriptional regulator
HEC99_RS16960	COG0142	geranyltranstransferase activity
HEC99_RS16970	COG0667	Aldo Keto reductase
HEC99_RS16975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HEC99_RS16980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEC99_RS16995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEC99_RS16995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEC99_RS17005	COG4238	major outer membrane lipoprotein
HEC99_RS17035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEC99_RS17045	COG1862	Preprotein translocase
HEC99_RS17065	COG0450	alkyl hydroperoxide reductase
HEC99_RS17070	COG0366	Alpha amylase catalytic
HEC99_RS17085	COG5002	protein histidine kinase activity
HEC99_RS17095	COG0420	3'-5' exonuclease activity
HEC99_RS17100	COG0419	ATPase involved in DNA repair
HEC99_RS17105	COG2814	Major facilitator Superfamily
HEC99_RS17110	COG1940	carbohydrate kinase activity
HEC99_RS17125	COG4126	flavin adenine dinucleotide binding
HEC99_RS17145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEC99_RS17150	COG3706	GGDEF domain
HEC99_RS17195	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HEC99_RS17200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEC99_RS17215	COG0113	porphobilinogen synthase activity
HEC99_RS17225	COG2079	MmgE PrpD family protein
HEC99_RS17250	COG1280	lysine exporter protein (LysE YggA)
HEC99_RS17270	COG1294	oxidase, subunit
HEC99_RS17275	COG1271	oxidase subunit
HEC99_RS17295	COG2814	Major facilitator Superfamily
HEC99_RS17305	COG0789	Transcriptional regulator
HEC99_RS17310	COG2217	Heavy metal translocating P-type atpase
HEC99_RS17315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC99_RS17360	COG2200	EAL domain
HEC99_RS17375	COG3539	Fimbrial protein
HEC99_RS17380	COG3121	Chaperone
HEC99_RS17385	COG3188	usher protein
HEC99_RS17420	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEC99_RS17435	COG2814	Major facilitator Superfamily
HEC99_RS17460	COG0582	viral genome integration into host DNA
HEC99_RS17500	COG2195	Cleaves the N-terminal amino acid of tripeptides
HEC99_RS17505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEC99_RS17510	COG1690	Belongs to the RtcB family
HEC99_RS17520	COG3034	peptidoglycan biosynthetic process
HEC99_RS17525	COG0121	glutamine amidotransferase
HEC99_RS17540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC99_RS17640	COG3209	COG3209 Rhs family protein
HEC99_RS17685	COG2226	methyltransferase
HEC99_RS17695	COG0741	lytic transglycosylase activity
HEC99_RS17695	COG1388	LysM domain
HEC99_RS17700	COG2226	methyltransferase
HEC99_RS17710	COG2814	Major facilitator Superfamily
HEC99_RS17715	COG0583	DNA-binding transcription factor activity
HEC99_RS17720	COG0656	L-ascorbic acid biosynthetic process
HEC99_RS17780	COG1720	tRNA m6t6A37 methyltransferase activity
HEC99_RS17790	COG3015	lipoprotein NlpE involved in copper resistance
HEC99_RS17795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEC99_RS17810	COG4568	rho-dependent transcription termination
HEC99_RS17820	COG0346	lactoylglutathione lyase activity
HEC99_RS17885	COG0575	Belongs to the CDS family
HEC99_RS17935	COG0477	Major facilitator Superfamily
HEC99_RS17950	COG3835	regulator
HEC99_RS17975	COG2860	membrane
HEC99_RS18005	COG3539	Fimbrial protein
HEC99_RS18010	COG3539	Fimbrial protein
HEC99_RS18015	COG3121	Chaperone
HEC99_RS18020	COG3188	usher protein
HEC99_RS18035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEC99_RS18040	COG1120	ATPase activity
HEC99_RS18045	COG4774	siderophore transport
HEC99_RS18050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEC99_RS18055	COG1643	Atp-dependent helicase
HEC99_RS18060	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HEC99_RS18085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEC99_RS18105	COG0726	polysaccharide deacetylase
HEC99_RS18110	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS18130	COG3539	Fimbrial protein
HEC99_RS18135	COG0842	Transport permease protein
HEC99_RS18140	COG1131	(ABC) transporter
HEC99_RS18145	COG0288	reversible hydration of carbon dioxide
HEC99_RS18155	COG4993	Dehydrogenase
HEC99_RS18160	COG2132	Multicopper oxidase
HEC99_RS18180	COG1349	DNA-binding transcription factor activity
HEC99_RS18220	COG3064	Membrane
HEC99_RS18235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC99_RS18240	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEC99_RS18245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEC99_RS18260	COG2211	Major facilitator Superfamily
HEC99_RS18265	COG3940	Belongs to the glycosyl hydrolase 43 family
HEC99_RS18270	COG3725	Membrane protein required for beta-lactamase induction
HEC99_RS18285	COG4969	Belongs to the N-Me-Phe pilin family
HEC99_RS18290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEC99_RS18295	COG1459	type II secretion system
HEC99_RS18320	COG0583	DNA-binding transcription factor activity
HEC99_RS18330	COG0494	nUDIX hydrolase
HEC99_RS18350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEC99_RS18355	COG0849	cell division
HEC99_RS18380	COG0772	Belongs to the SEDS family
HEC99_RS18395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEC99_RS18405	COG0768	penicillin binding
HEC99_RS18500	COG0586	Pfam SNARE associated Golgi protein
HEC99_RS18540	COG0417	DNA replication proofreading
HEC99_RS18570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEC99_RS18605	COG3119	arylsulfatase activity
HEC99_RS18625	COG2271	Major facilitator Superfamily
HEC99_RS18635	COG0644	oxidoreductase
HEC99_RS18785	COG1047	Peptidyl-prolyl cis-trans
HEC99_RS18800	COG0196	riboflavin kinase activity
HEC99_RS18825	COG0583	DNA-binding transcription factor activity
HEC99_RS18845	COG0641	radical SAM
HEC99_RS18850	COG3119	arylsulfatase activity
HEC99_RS18860	COG0737	Belongs to the 5'-nucleotidase family
HEC99_RS18875	COG0583	DNA-binding transcription factor activity
HEC99_RS18895	COG3121	Chaperone
HEC99_RS18900	COG3539	Fimbrial protein
HEC99_RS18915	COG3188	usher protein
HEC99_RS18980	COG4735	regulation of single-species biofilm formation
HEC99_RS18985	COG1584	GPR1 FUN34 yaaH family protein
HEC99_RS18990	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEC99_RS19000	COG1115	amino acid carrier protein
HEC99_RS19010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEC99_RS19020	COG0460	homoserine dehydrogenase
HEC99_RS19020	COG0527	aspartate kinase activity
HEC99_RS19030	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HEC99_RS19040	COG0745	RESPONSE REGULATOR receiver
HEC99_RS19060	COG3121	Chaperone
HEC99_RS19080	COG4452	Inner membrane protein CreD
HEC99_RS19085	COG2205	protein histidine kinase activity
HEC99_RS19090	COG0745	RESPONSE REGULATOR receiver
HEC99_RS19095	COG3045	CreA protein
HEC99_RS19100	COG2207	Transcriptional regulator
HEC99_RS19100	COG3708	Transcriptional regulator
HEC99_RS19125	COG0488	(ABC) transporter
HEC99_RS19140	COG0560	Phosphoserine phosphatase
HEC99_RS19145	COG3726	membrane protein affecting hemolysin expression
HEC99_RS19155	COG3550	peptidyl-serine autophosphorylation
HEC99_RS19180	COG1328	CTP reductase activity
HEC99_RS19185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC99_RS19190	COG0084	hydrolase, TatD family'
HEC99_RS19195	COG4667	esterase of the alpha-beta hydrolase superfamily
HEC99_RS19205	COG2823	Periplasmic or secreted lipoprotein
HEC99_RS19215	COG1011	Hydrolase
HEC99_RS19225	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HEC99_RS19255	COG3706	GGDEF domain
HEC99_RS19260	COG4114	ferric iron reductase
HEC99_RS19265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC99_RS19270	COG2197	response regulator
HEC99_RS19275	COG2197	response regulator
HEC99_RS19280	COG2966	Psort location CytoplasmicMembrane, score
HEC99_RS19295	COG1484	DNA-dependent DNA replication
HEC99_RS19315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEC99_RS19320	COG3716	PTS system mannose fructose sorbose family IID component
HEC99_RS19325	COG3715	PTS system
HEC99_RS19330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC99_RS19345	COG0840	transmembrane signaling receptor activity
HEC99_RS19350	COG1966	Carbon starvation protein
HEC99_RS19355	COG2879	small protein
HEC99_RS19360	COG0523	cobalamin synthesis protein
HEC99_RS19380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HEC99_RS19385	COG0732	type I restriction modification DNA specificity domain
HEC99_RS19390	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HEC99_RS19395	COG3586	endonuclease activity
HEC99_RS19410	COG1012	belongs to the aldehyde dehydrogenase family
HEC99_RS19415	COG5464	transposase or invertase
HEC99_RS19425	COG2733	membrane
HEC99_RS19430	COG0477	Major facilitator Superfamily
HEC99_RS19435	COG3366	ferrous iron transmembrane transporter activity
HEC99_RS19440	COG0700	Nucleoside recognition
HEC99_RS19445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEC99_RS19450	COG0583	DNA-binding transcription factor activity
HEC99_RS19470	COG2186	Transcriptional regulator
HEC99_RS19475	COG0412	Dienelactone hydrolase
HEC99_RS19500	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HEC99_RS19520	COG3204	pilus organization
HEC99_RS19605	COG1064	alcohol dehydrogenase
HEC99_RS19610	COG3265	gluconokinase activity
HEC99_RS19615	COG1063	alcohol dehydrogenase
HEC99_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
HEC99_RS19625	COG2610	gluconate transmembrane transporter activity
HEC99_RS19630	COG1609	Transcriptional regulator
HEC99_RS19635	COG0795	lipopolysaccharide-transporting ATPase activity
HEC99_RS19640	COG0795	lipopolysaccharide-transporting ATPase activity
HEC99_RS19650	COG2927	DNA polymerase III (CHI subunit)
HEC99_RS19690	COG2731	YhcH YjgK YiaL family protein
HEC99_RS19710	COG1288	antiporter activity
HEC99_RS19715	COG1438	arginine binding
HEC99_RS19765	COG1263	PTS System
HEC99_RS19765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC99_RS19770	COG0366	Alpha amylase catalytic
HEC99_RS19785	COG2026	Addiction module toxin, RelE StbE family
HEC99_RS19790	COG3077	Addiction module antitoxin, RelB DinJ family
HEC99_RS19795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS19795	COG3711	transcriptional antiterminator
HEC99_RS19810	COG3964	amidohydrolase
HEC99_RS19845	COG0312	modulator of DNA gyrase
HEC99_RS19855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEC99_RS19870	COG3964	amidohydrolase
HEC99_RS19875	COG2271	Major facilitator Superfamily
HEC99_RS19880	COG2105	PFAM AIG2 family protein
HEC99_RS19900	COG1253	flavin adenine dinucleotide binding
HEC99_RS19910	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HEC99_RS19925	COG1733	regulation of RNA biosynthetic process
HEC99_RS19930	COG0702	epimerase
HEC99_RS19935	COG0697	spore germination
HEC99_RS19955	COG1113	amino acid transport
HEC99_RS19960	COG0545	Peptidyl-prolyl cis-trans isomerase
HEC99_RS19965	COG3061	Opacity-associated protein A
HEC99_RS19980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEC99_RS20020	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC99_RS20040	COG1073	alpha beta
HEC99_RS20045	COG3650	response to hydrogen peroxide
HEC99_RS20055	COG1960	acyl-CoA dehydrogenase activity
HEC99_RS20060	COG0754	glutathionylspermidine amidase activity
HEC99_RS20065	COG5463	Belongs to the UPF0441 family
HEC99_RS20070	COG3766	membrane
HEC99_RS20085	COG1842	Phage shock protein A
HEC99_RS20090	COG3789	protein conserved in bacteria
HEC99_RS20100	COG0557	exoribonuclease II activity
HEC99_RS20115	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HEC99_RS20120	COG0330	HflC and HflK could
HEC99_RS20125	COG0330	HflC and HflK could
HEC99_RS20130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEC99_RS20155	COG0802	atpase or kinase
HEC99_RS20160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEC99_RS20160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEC99_RS20185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC99_RS20205	COG1511	domain protein
HEC99_RS20205	COG3264	Mechanosensitive ion channel
HEC99_RS20225	COG1053	succinate dehydrogenase
HEC99_RS20230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEC99_RS20260	COG5510	response to toxic substance
HEC99_RS20300	COG0531	amino acid
HEC99_RS20305	COG3030	protein affecting phage T7 exclusion by the F plasmid
HEC99_RS20310	COG1027	Aspartate ammonia-lyase
HEC99_RS20315	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC99_RS20330	COG1309	transcriptional regulator
HEC99_RS20370	COG2197	response regulator
HEC99_RS20375	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HEC99_RS20395	COG3381	protein complex oligomerization
HEC99_RS20400	COG3302	dmso reductase anchor subunit
HEC99_RS20405	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS20415	COG3290	protein histidine kinase activity
HEC99_RS20420	COG4565	transcriptional regulatory protein
HEC99_RS20430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC99_RS20435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC99_RS20435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC99_RS20450	COG2169	Transcriptional regulator
HEC99_RS20455	COG1982	Orn Lys Arg decarboxylase major
HEC99_RS20460	COG2207	Transcriptional regulator
HEC99_RS20465	COG0531	amino acid
HEC99_RS20495	COG2824	Alkylphosphonate utilization operon protein PhnA
HEC99_RS20500	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HEC99_RS20520	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HEC99_RS20525	COG1301	dicarboxylic acid transport
HEC99_RS20530	COG4235	cytochrome complex assembly
HEC99_RS20535	COG3088	subunit of a heme lyase
HEC99_RS20540	COG1138	Cytochrome C-type biogenesis protein
HEC99_RS20545	COG3301	Polysulphide reductase, NrfD
HEC99_RS20550	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS20555	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HEC99_RS20565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEC99_RS20570	COG3162	membrane
HEC99_RS20580	COG1346	cytolysis
HEC99_RS20585	COG1380	Effector of murein hydrolase LrgA
HEC99_RS20590	COG0583	DNA-binding transcription factor activity
HEC99_RS20595	COG0025	NhaP-type Na H and K H
HEC99_RS20600	COG2252	PERMEase
HEC99_RS20620	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HEC99_RS20680	COG2315	Protein conserved in bacteria
HEC99_RS20730	COG0735	belongs to the Fur family
HEC99_RS20745	COG0534	Mate efflux family protein
HEC99_RS20755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEC99_RS20810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC99_RS20835	COG0527	aspartate kinase activity
HEC99_RS20865	COG0561	phosphatase activity
HEC99_RS20870	COG1349	DNA-binding transcription factor activity
HEC99_RS20885	COG3122	Protein conserved in bacteria
HEC99_RS20930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEC99_RS21035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEC99_RS21040	COG2104	thiamine diphosphate biosynthetic process
HEC99_RS21105	COG0250	Participates in transcription elongation, termination and antitermination
HEC99_RS21215	COG0583	DNA-binding transcription factor activity
HEC99_RS21250	COG2207	Transcriptional regulator
HEC99_RS21255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC99_RS21260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC99_RS21265	COG1882	Formate acetyltransferase
HEC99_RS21270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC99_RS21275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC99_RS21280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS21280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEC99_RS21280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC99_RS21290	COG0371	Dehydrogenase
HEC99_RS21295	COG3738	Protein conserved in bacteria
HEC99_RS21315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEC99_RS21320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEC99_RS21325	COG0737	Belongs to the 5'-nucleotidase family
HEC99_RS21340	COG0668	transmembrane transport
HEC99_RS21345	COG0460	homoserine dehydrogenase
HEC99_RS21345	COG0527	aspartate kinase activity
HEC99_RS21350	COG0626	cystathionine gamma-synthase activity
HEC99_RS21375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEC99_RS21380	COG1609	Transcriptional regulator
HEC99_RS21385	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEC99_RS21400	COG1575	Belongs to the MenA family. Type 1 subfamily
HEC99_RS21415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEC99_RS21425	COG1494	fructose-1,6-bisphosphatase
HEC99_RS21435	COG3152	Membrane
HEC99_RS21465	COG1879	ABC-type sugar transport system periplasmic component
HEC99_RS21490	COG1070	Carbohydrate kinase
HEC99_RS21500	COG2134	cdp-diacylglycerol pyrophosphatase
HEC99_RS21510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEC99_RS21520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS21525	COG2211	Major facilitator Superfamily
HEC99_RS21550	COG3678	ATP-independent chaperone mediated protein folding
HEC99_RS21555	COG0745	RESPONSE REGULATOR receiver
HEC99_RS21560	COG2205	protein histidine kinase activity
HEC99_RS21575	COG2258	MOSC domain
HEC99_RS21580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEC99_RS21625	COG1454	alcohol dehydrogenase
HEC99_RS21640	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HEC99_RS21670	COG0437	4 iron, 4 sulfur cluster binding
HEC99_RS21675	COG2864	formate dehydrogenase
HEC99_RS21690	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HEC99_RS21700	COG4680	protein conserved in bacteria
HEC99_RS21705	COG5499	transcription regulator containing HTH domain
HEC99_RS21710	COG0456	acetyltransferase
HEC99_RS21725	COG1011	Hydrolase
HEC99_RS21730	COG1349	DNA-binding transcription factor activity
HEC99_RS21735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS21745	COG3684	Belongs to the aldolase LacD family
HEC99_RS21755	COG2017	converts alpha-aldose to the beta-anomer
HEC99_RS21760	COG1501	Belongs to the glycosyl hydrolase 31 family
HEC99_RS21805	COG0561	phosphatase activity
HEC99_RS21860	COG0204	Acyl-transferase
HEC99_RS21875	COG3084	Protein conserved in bacteria
HEC99_RS21885	COG1763	Mo-molybdopterin cofactor biosynthetic process
HEC99_RS21925	COG1739	Uncharacterized protein family UPF0029
HEC99_RS21955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEC99_RS21970	COG0805	protein transport
HEC99_RS22015	COG0641	radical SAM
HEC99_RS22035	COG0561	phosphatase activity
HEC99_RS22040	COG2267	carboxylic ester hydrolase activity
HEC99_RS22095	COG1011	Hydrolase
HEC99_RS22155	COG2959	enzyme of heme biosynthesis
HEC99_RS22160	COG3071	HemY protein
HEC99_RS22205	COG2244	polysaccharide biosynthetic process
HEC99_RS22210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEC99_RS22215	COG0456	acetyltransferase
HEC99_RS22220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEC99_RS22220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEC99_RS22225	COG1088	dTDP-glucose 4,6-dehydratase activity
HEC99_RS22230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEC99_RS22260	COG3118	belongs to the thioredoxin family
HEC99_RS22325	COG3978	acetolactate synthase activity
HEC99_RS22385	COG2186	Transcriptional regulator
HEC99_RS22390	COG0477	Major facilitator Superfamily
HEC99_RS22395	COG0477	Major facilitator Superfamily
HEC99_RS22400	COG1609	Transcriptional regulator
HEC99_RS22405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC99_RS22415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC99_RS22450	COG1522	sequence-specific DNA binding
HEC99_RS22455	COG0716	FMN binding
HEC99_RS22470	COG3312	ion transport
HEC99_RS22530	COG4533	DNA binding
HEC99_RS22535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEC99_RS22540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC99_RS22540	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HEC99_RS22540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC99_RS22545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEC99_RS22550	COG0573	inorganic phosphate transmembrane transporter activity
HEC99_RS22555	COG0581	inorganic phosphate transmembrane transporter activity
HEC99_RS22565	COG0704	Plays a role in the regulation of phosphate uptake
HEC99_RS22570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC99_RS22575	COG2252	PERMEase
HEC99_RS22580	COG0431	NADPH-dependent FMN reductase
HEC99_RS22585	COG2091	lysine biosynthetic process via aminoadipic acid
HEC99_RS22715	COG2026	Addiction module toxin, RelE StbE family
HEC99_RS22765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC99_RS23275	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HEC99_RS23315	COG3111	PFAM Bacterial OB fold (BOF) protein
HEC99_RS23375	COG3204	pilus organization
HEC99_RS23385	COG2207	Transcriptional regulator
HEC99_RS23390	COG3204	pilus organization
HEC99_RS23570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HEC99_RS23635	COG1388	LysM domain
HEC99_RS23635	COG4932	domain protein
HEC99_RS23635	COG2373	Large extracellular alpha-helical protein
HEC99_RS23640	COG1470	cell adhesion involved in biofilm formation
HEC99_RS23640	COG1388	LysM domain