locus-tag	class	description
APS46_RS00010	COG0527	aspartate kinase activity
APS46_RS00010	COG0460	homoserine dehydrogenase
APS46_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APS46_RS00030	COG1115	amino acid carrier protein
APS46_RS00040	COG0521	Mo-molybdopterin cofactor biosynthetic process
APS46_RS00045	COG1584	GPR1 FUN34 yaaH family protein
APS46_RS00050	COG4735	regulation of single-species biofilm formation
APS46_RS00110	COG3121	Chaperone
APS46_RS00115	COG3188	usher protein
APS46_RS00130	COG3539	Fimbrial protein
APS46_RS00135	COG3121	Chaperone
APS46_RS00170	COG3119	arylsulfatase activity
APS46_RS00175	COG0641	radical SAM
APS46_RS00195	COG0583	DNA-binding transcription factor activity
APS46_RS00220	COG0196	riboflavin kinase activity
APS46_RS00235	COG1047	Peptidyl-prolyl cis-trans
APS46_RS00325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APS46_RS00380	COG0644	oxidoreductase
APS46_RS00390	COG2271	Major facilitator Superfamily
APS46_RS00415	COG3119	arylsulfatase activity
APS46_RS00480	COG0417	DNA replication proofreading
APS46_RS00515	COG0586	Pfam SNARE associated Golgi protein
APS46_RS00605	COG0768	penicillin binding
APS46_RS00610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APS46_RS00615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APS46_RS00630	COG0772	Belongs to the SEDS family
APS46_RS00655	COG0849	cell division
APS46_RS00660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APS46_RS00680	COG0494	nUDIX hydrolase
APS46_RS00710	COG1459	type II secretion system
APS46_RS00715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APS46_RS00720	COG4969	Belongs to the N-Me-Phe pilin family
APS46_RS00735	COG3725	Membrane protein required for beta-lactamase induction
APS46_RS00740	COG3940	Belongs to the glycosyl hydrolase 43 family
APS46_RS00745	COG2211	Major facilitator Superfamily
APS46_RS00760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APS46_RS00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS46_RS00770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS46_RS00785	COG3064	Membrane
APS46_RS00855	COG1349	DNA-binding transcription factor activity
APS46_RS00875	COG2132	Multicopper oxidase
APS46_RS00880	COG4993	Dehydrogenase
APS46_RS00890	COG0288	reversible hydration of carbon dioxide
APS46_RS00895	COG1131	(ABC) transporter
APS46_RS00900	COG0842	Transport permease protein
APS46_RS00905	COG3539	Fimbrial protein
APS46_RS00925	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS00930	COG0726	polysaccharide deacetylase
APS46_RS00950	COG3539	Fimbrial protein
APS46_RS00955	COG3188	usher protein
APS46_RS00960	COG3121	Chaperone
APS46_RS00985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APS46_RS01010	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
APS46_RS01015	COG1643	Atp-dependent helicase
APS46_RS01020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APS46_RS01025	COG4774	siderophore transport
APS46_RS01030	COG1120	ATPase activity
APS46_RS01035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APS46_RS01050	COG3188	usher protein
APS46_RS01055	COG3121	Chaperone
APS46_RS01060	COG3539	Fimbrial protein
APS46_RS01065	COG3539	Fimbrial protein
APS46_RS01095	COG2860	membrane
APS46_RS01120	COG3835	regulator
APS46_RS01130	COG0477	Major facilitator Superfamily
APS46_RS01180	COG0575	Belongs to the CDS family
APS46_RS01240	COG1982	Orn Lys Arg decarboxylase major
APS46_RS01245	COG0346	lactoylglutathione lyase activity
APS46_RS01255	COG4568	rho-dependent transcription termination
APS46_RS01270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APS46_RS01275	COG3015	lipoprotein NlpE involved in copper resistance
APS46_RS01285	COG1720	tRNA m6t6A37 methyltransferase activity
APS46_RS01310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APS46_RS01350	COG0583	DNA-binding transcription factor activity
APS46_RS01355	COG2814	Major facilitator Superfamily
APS46_RS01365	COG2226	methyltransferase
APS46_RS01370	COG0741	lytic transglycosylase activity
APS46_RS01370	COG1388	LysM domain
APS46_RS01380	COG2226	methyltransferase
APS46_RS01490	COG2885	chlorophyll binding
APS46_RS01490	COG3047	cAMP biosynthetic process
APS46_RS01545	COG3209	COG3209 Rhs family protein
APS46_RS01600	COG1522	sequence-specific DNA binding
APS46_RS01625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APS46_RS01640	COG0121	glutamine amidotransferase
APS46_RS01645	COG3034	peptidoglycan biosynthetic process
APS46_RS01655	COG1690	Belongs to the RtcB family
APS46_RS01660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APS46_RS01665	COG2195	Cleaves the N-terminal amino acid of tripeptides
APS46_RS01705	COG0582	viral genome integration into host DNA
APS46_RS01815	COG0305	Participates in initiation and elongation during chromosome replication
APS46_RS01850	COG0484	heat shock protein binding
APS46_RS01860	COG3772	lysozyme
APS46_RS01975	COG0463	Glycosyl transferase, family 2
APS46_RS01980	COG2246	polysaccharide biosynthetic process
APS46_RS02000	COG2814	Major facilitator Superfamily
APS46_RS02015	COG0179	Fumarylacetoacetate (FAA) hydrolase
APS46_RS02050	COG3188	usher protein
APS46_RS02055	COG3121	Chaperone
APS46_RS02060	COG3539	Fimbrial protein
APS46_RS02075	COG2200	EAL domain
APS46_RS02130	COG0789	Transcriptional regulator
APS46_RS02145	COG2814	Major facilitator Superfamily
APS46_RS02165	COG1271	oxidase subunit
APS46_RS02170	COG1294	oxidase, subunit
APS46_RS02190	COG1280	lysine exporter protein (LysE YggA)
APS46_RS02215	COG2079	MmgE PrpD family protein
APS46_RS02225	COG0113	porphobilinogen synthase activity
APS46_RS02240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APS46_RS02245	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
APS46_RS02290	COG3706	GGDEF domain
APS46_RS02295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APS46_RS02315	COG4126	flavin adenine dinucleotide binding
APS46_RS02330	COG1940	carbohydrate kinase activity
APS46_RS02335	COG2814	Major facilitator Superfamily
APS46_RS02340	COG0419	ATPase involved in DNA repair
APS46_RS02345	COG0420	3'-5' exonuclease activity
APS46_RS02360	COG5002	protein histidine kinase activity
APS46_RS02375	COG0366	Alpha amylase catalytic
APS46_RS02380	COG0450	alkyl hydroperoxide reductase
APS46_RS02400	COG1862	Preprotein translocase
APS46_RS02410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APS46_RS02440	COG4238	major outer membrane lipoprotein
APS46_RS02450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APS46_RS02450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APS46_RS02465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APS46_RS02470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APS46_RS02475	COG0667	Aldo Keto reductase
APS46_RS02485	COG0142	geranyltranstransferase activity
APS46_RS02520	COG2188	Transcriptional regulator
APS46_RS02550	COG2814	Major facilitator Superfamily
APS46_RS02570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APS46_RS02575	COG1845	cytochrome c oxidase, subunit III
APS46_RS02580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APS46_RS02585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APS46_RS02590	COG2223	nitrite transmembrane transporter activity
APS46_RS02595	COG3056	Lipoprotein
APS46_RS02600	COG0271	Belongs to the BolA IbaG family
APS46_RS02620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APS46_RS02630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS46_RS02635	COG1555	photosystem II stabilization
APS46_RS02640	COG0824	Thioesterase
APS46_RS02650	COG4533	DNA binding
APS46_RS02665	COG1522	sequence-specific DNA binding
APS46_RS02670	COG1132	(ABC) transporter
APS46_RS02675	COG1132	(ABC) transporter
APS46_RS02680	COG0347	Belongs to the P(II) protein family
APS46_RS02685	COG0004	ammonium transporteR
APS46_RS02690	COG1946	Acyl-CoA thioesterase
APS46_RS02695	COG3126	Type III secretion system lipoprotein chaperone (YscW)
APS46_RS02700	COG3695	enzyme binding
APS46_RS02710	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APS46_RS02730	COG0110	maltose O-acetyltransferase activity
APS46_RS02745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS46_RS02750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS46_RS02755	COG1309	transcriptional regulator
APS46_RS02760	COG1196	nuclear chromosome segregation
APS46_RS02760	COG3264	Mechanosensitive ion channel
APS46_RS02765	COG5464	transposase or invertase
APS46_RS02770	COG5464	transposase or invertase
APS46_RS02780	COG3923	Primosomal replication protein n
APS46_RS02785	COG2832	Protein of unknown function (DUF454)
APS46_RS02835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APS46_RS02835	COG4651	solute:proton antiporter activity
APS46_RS02840	COG2223	nitrite transmembrane transporter activity
APS46_RS02855	COG3735	TraB family
APS46_RS02875	COG1585	Membrane protein implicated in regulation of membrane protease activity
APS46_RS02880	COG0330	HflC and HflK could
APS46_RS02885	COG4619	ABC transporter
APS46_RS02890	COG0390	transport system, permease component
APS46_RS02895	COG3118	belongs to the thioredoxin family
APS46_RS02900	COG0300	oxidoreductase activity
APS46_RS02905	COG2755	lipolytic protein G-D-S-L family
APS46_RS02910	COG4181	ATPase activity
APS46_RS02915	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APS46_RS02925	COG1464	Belongs to the NlpA lipoprotein family
APS46_RS02960	COG3960	tartronate-semialdehyde synthase activity
APS46_RS02965	COG3622	Belongs to the hyi family
APS46_RS02970	COG2084	Dehydrogenase
APS46_RS02980	COG1953	Uracil, thiamine, allantoin
APS46_RS02990	COG2233	PERMEase
APS46_RS02995	COG1929	Belongs to the glycerate kinase type-1 family
APS46_RS03000	COG3257	ureidoglycine aminohydrolase activity
APS46_RS03005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APS46_RS03010	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APS46_RS03015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APS46_RS03020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APS46_RS03030	COG0549	Belongs to the carbamate kinase family
APS46_RS03035	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APS46_RS03040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APS46_RS03050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APS46_RS03070	COG1988	membrane-bound metal-dependent
APS46_RS03075	COG2501	S4 domain
APS46_RS03140	COG0582	viral genome integration into host DNA
APS46_RS03145	COG2963	transposase activity
APS46_RS03155	COG0463	Glycosyl transferase, family 2
APS46_RS03160	COG2246	polysaccharide biosynthetic process
APS46_RS03170	COG5002	protein histidine kinase activity
APS46_RS03175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS46_RS03180	COG2207	Transcriptional regulator
APS46_RS03185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS46_RS03195	COG3059	membrane
APS46_RS03205	COG1113	amino acid transport
APS46_RS03210	COG0668	transmembrane transport
APS46_RS03220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
APS46_RS03220	COG3933	PFAM sigma-54 factor interaction domain-containing protein
APS46_RS03225	COG2222	sugar isomerase
APS46_RS03235	COG3716	PTS system mannose fructose sorbose family IID component
APS46_RS03260	COG2315	Protein conserved in bacteria
APS46_RS03285	COG2977	Belongs to the P-Pant transferase superfamily
APS46_RS03290	COG4771	TonB-dependent receptor
APS46_RS03295	COG2382	esterase
APS46_RS03300	COG3251	PFAM MbtH domain protein
APS46_RS03305	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
APS46_RS03305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APS46_RS03310	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APS46_RS03315	COG1120	ATPase activity
APS46_RS03320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS46_RS03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS46_RS03335	COG4592	Periplasmic binding protein
APS46_RS03340	COG1169	isochorismate synthase
APS46_RS03345	COG1021	2,3-dihydroxybenzoate-AMP ligase
APS46_RS03350	COG1535	isochorismatase
APS46_RS03350	COG3433	isochorismatase activity
APS46_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS03365	COG1966	Carbon starvation protein
APS46_RS03370	COG2879	small protein
APS46_RS03375	COG0371	Dehydrogenase
APS46_RS03380	COG0436	Aminotransferase
APS46_RS03385	COG1475	DNA binding
APS46_RS03390	COG3969	phosphoadenosine phosphosulfate
APS46_RS03395	COG0583	DNA-binding transcription factor activity
APS46_RS03400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APS46_RS03420	COG0243	molybdopterin cofactor binding
APS46_RS03440	COG1063	alcohol dehydrogenase
APS46_RS03445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APS46_RS03450	COG3719	Belongs to the RNase T2 family
APS46_RS03455	COG0471	metal ion transport
APS46_RS03470	COG3051	citrate lyase alpha subunit
APS46_RS03475	COG2301	Belongs to the HpcH HpaI aldolase family
APS46_RS03485	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
APS46_RS03490	COG3290	protein histidine kinase activity
APS46_RS03495	COG4565	transcriptional regulatory protein
APS46_RS03500	COG3069	C4-dicarboxylate transmembrane transporter activity
APS46_RS03520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APS46_RS03535	COG0583	DNA-binding transcription factor activity
APS46_RS03550	COG1686	Belongs to the peptidase S11 family
APS46_RS03560	COG0772	Belongs to the SEDS family
APS46_RS03565	COG0768	penicillin binding
APS46_RS03575	COG0799	negative regulation of ribosome biogenesis
APS46_RS03600	COG1466	dna polymerase III delta subunit
APS46_RS03630	COG3290	protein histidine kinase activity
APS46_RS03630	COG3829	transcription factor binding
APS46_RS03635	COG2888	peptidyl-tyrosine sulfation
APS46_RS03650	COG2214	Heat shock protein DnaJ domain protein
APS46_RS03660	COG2214	Heat shock protein DnaJ domain protein
APS46_RS03665	COG0443	Heat shock 70 kDa protein
APS46_RS03680	COG1126	abc transporter atp-binding protein
APS46_RS03685	COG0765	amino acid transport
APS46_RS03690	COG0765	amino acid transport
APS46_RS03715	COG1702	phosphate starvation-inducible protein PhoH
APS46_RS03725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS46_RS03770	COG0367	asparagine synthase
APS46_RS03775	COG0647	UMP catabolic process
APS46_RS03780	COG1846	Transcriptional regulator
APS46_RS03780	COG1940	carbohydrate kinase activity
APS46_RS03785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APS46_RS03825	COG1053	succinate dehydrogenase
APS46_RS03830	COG0583	DNA-binding transcription factor activity
APS46_RS03835	COG0735	belongs to the Fur family
APS46_RS03850	COG0596	Alpha beta hydrolase
APS46_RS03860	COG0033	Phosphoglucomutase
APS46_RS03870	COG0531	amino acid
APS46_RS03875	COG1982	Orn Lys Arg decarboxylase major
APS46_RS03885	COG0745	RESPONSE REGULATOR receiver
APS46_RS03890	COG2205	protein histidine kinase activity
APS46_RS03935	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APS46_RS03940	COG1984	allophanate hydrolase subunit 2
APS46_RS03955	COG0582	viral genome integration into host DNA
APS46_RS03995	COG1216	Glycosyl transferase, family 2
APS46_RS04020	COG3180	Ammonia monooxygenase
APS46_RS04040	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APS46_RS04055	COG0567	Dehydrogenase, E1 component
APS46_RS04060	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS46_RS04070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APS46_RS04080	COG1271	oxidase subunit
APS46_RS04085	COG1294	oxidase, subunit
APS46_RS04090	COG4890	Cyd operon protein YbgT
APS46_RS04095	COG3790	cyd operon protein YbgE
APS46_RS04100	COG0824	Thioesterase
APS46_RS04105	COG0811	peptide transport
APS46_RS04110	COG0848	biopolymer transport protein
APS46_RS04115	COG3064	Membrane
APS46_RS04125	COG2885	chlorophyll binding
APS46_RS04130	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
APS46_RS04195	COG1230	cation diffusion facilitator family transporter
APS46_RS04205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APS46_RS04210	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APS46_RS04210	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APS46_RS04220	COG0583	DNA-binding transcription factor activity
APS46_RS04225	COG0583	DNA-binding transcription factor activity
APS46_RS04230	COG0490	domain, Protein
APS46_RS04230	COG0471	metal ion transport
APS46_RS04245	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APS46_RS04255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS46_RS04260	COG1120	ATPase activity
APS46_RS04270	COG2017	converts alpha-aldose to the beta-anomer
APS46_RS04295	COG1119	ATPase activity
APS46_RS04300	COG2005	Transcriptional regulator
APS46_RS04300	COG3585	molybdate ion transport
APS46_RS04310	COG0725	ABC transporter, periplasmic molybdate-binding protein
APS46_RS04315	COG4149	molybdate abc transporter
APS46_RS04325	COG0561	phosphatase activity
APS46_RS04335	COG4677	pectinesterase activity
APS46_RS04365	COG1881	PFAM PEBP family protein
APS46_RS04420	COG0521	Mo-molybdopterin cofactor biosynthetic process
APS46_RS04430	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APS46_RS04440	COG0670	Belongs to the BI1 family
APS46_RS04460	COG0392	lysyltransferase activity
APS46_RS04465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS46_RS04470	COG3568	Endonuclease Exonuclease Phosphatase
APS46_RS04480	COG0842	Transport permease protein
APS46_RS04485	COG0842	Transport permease protein
APS46_RS04490	COG1131	(ABC) transporter
APS46_RS04500	COG1309	transcriptional regulator
APS46_RS04505	COG0513	Belongs to the DEAD box helicase family
APS46_RS04515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APS46_RS04530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APS46_RS04540	COG0668	transmembrane transport
APS46_RS04545	COG1126	abc transporter atp-binding protein
APS46_RS04550	COG0765	amino acid transport
APS46_RS04555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS46_RS04570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APS46_RS04575	COG2194	sulfuric ester hydrolase activity
APS46_RS04585	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APS46_RS04590	COG1376	ErfK ybiS ycfS ynhG family protein
APS46_RS04595	COG0488	(ABC) transporter
APS46_RS04605	COG0561	phosphatase activity
APS46_RS04610	COG1882	Formate acetyltransferase
APS46_RS04615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APS46_RS04665	COG2301	Belongs to the HpcH HpaI aldolase family
APS46_RS04685	COG1960	acyl-CoA dehydrogenase activity
APS46_RS04695	COG0583	DNA-binding transcription factor activity
APS46_RS04700	COG2610	gluconate transmembrane transporter activity
APS46_RS04705	COG2133	pyrroloquinoline quinone binding
APS46_RS04710	COG2133	pyrroloquinoline quinone binding
APS46_RS04715	COG0625	glutathione transferase activity
APS46_RS04720	COG1686	Belongs to the peptidase S11 family
APS46_RS04725	COG1349	DNA-binding transcription factor activity
APS46_RS04730	COG0671	phosphoesterase, PA-phosphatase related
APS46_RS04735	COG2814	Major facilitator Superfamily
APS46_RS04740	COG0561	phosphatase activity
APS46_RS04745	COG0738	Major facilitator superfamily
APS46_RS04750	COG3226	Transcriptional regulator
APS46_RS04790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APS46_RS04795	COG3842	ATPase activity
APS46_RS04800	COG1176	ABC-type spermidine putrescine transport system, permease component I
APS46_RS04805	COG1177	transmembrane transport
APS46_RS04835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS46_RS04840	COG4160	amino acid transport
APS46_RS04845	COG4215	(ABC) transporter
APS46_RS04850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS46_RS04855	COG1126	abc transporter atp-binding protein
APS46_RS04870	COG3023	N-Acetylmuramoyl-L-alanine amidase
APS46_RS04875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS46_RS04880	COG0702	epimerase
APS46_RS04885	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APS46_RS04890	COG0028	Belongs to the TPP enzyme family
APS46_RS04895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APS46_RS04905	COG2431	L-lysine efflux transmembrane transporter activity
APS46_RS04910	COG3593	DNA synthesis involved in DNA repair
APS46_RS04915	COG2990	Protein conserved in bacteria
APS46_RS04920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS46_RS04925	COG1136	(ABC) transporter
APS46_RS04925	COG0577	efflux transmembrane transporter activity
APS46_RS04930	COG1278	Cold shock
APS46_RS04940	COG0542	response to heat
APS46_RS04970	COG1335	isochorismatase
APS46_RS04980	COG0583	DNA-binding transcription factor activity
APS46_RS05000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APS46_RS05005	COG4988	ABC transporter
APS46_RS05010	COG0492	ferredoxin-NADP+ reductase activity
APS46_RS05030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APS46_RS05040	COG0243	molybdopterin cofactor binding
APS46_RS05045	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS05050	COG3302	dmso reductase anchor subunit
APS46_RS05065	COG0531	amino acid
APS46_RS05070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APS46_RS05080	COG1882	Formate acetyltransferase
APS46_RS05085	COG2116	formate transmembrane transporter activity
APS46_RS05090	COG1944	ATP diphosphatase activity
APS46_RS05095	COG2323	membrane
APS46_RS05110	COG0501	Belongs to the peptidase M48B family
APS46_RS05120	COG0539	negative regulation of cytoplasmic translation
APS46_RS05130	COG0658	competence protein
APS46_RS05130	COG2333	competence protein COMEC
APS46_RS05145	COG3214	Protein conserved in bacteria
APS46_RS05160	COG3173	Aminoglycoside phosphotransferase
APS46_RS05165	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APS46_RS05170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APS46_RS05180	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APS46_RS05190	COG2989	Protein conserved in bacteria
APS46_RS05195	COG3108	Peptidase M15
APS46_RS05200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APS46_RS05220	COG1522	sequence-specific DNA binding
APS46_RS05235	COG1115	amino acid carrier protein
APS46_RS05245	COG0582	viral genome integration into host DNA
APS46_RS05375	COG0484	heat shock protein binding
APS46_RS05400	COG3772	lysozyme
APS46_RS05515	COG5301	cellulose 1,4-beta-cellobiosidase activity
APS46_RS05535	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APS46_RS05545	COG0308	aminopeptidase N
APS46_RS05560	COG0633	Ferredoxin
APS46_RS05560	COG3217	Mosc domain protein beta barrel domain protein
APS46_RS05570	COG0488	(ABC) transporter
APS46_RS05575	COG2995	paraquat-inducible protein a
APS46_RS05580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APS46_RS05580	COG3008	intermembrane lipid transfer
APS46_RS05585	COG3009	Protein conserved in bacteria
APS46_RS05590	COG3130	regulation of translation
APS46_RS05600	COG1067	ATP-dependent peptidase activity
APS46_RS05620	COG3070	regulator of competence-specific genes
APS46_RS05625	COG1289	transmembrane transporter activity
APS46_RS05630	COG3304	Inner membrane component domain
APS46_RS05635	COG0210	DNA helicase
APS46_RS05650	COG1832	CoA-binding protein
APS46_RS05665	COG1881	PFAM PEBP family protein
APS46_RS05685	COG0670	Belongs to the BI1 family
APS46_RS05735	COG2205	protein histidine kinase activity
APS46_RS05755	COG2368	4-hydroxyphenylacetate
APS46_RS05760	COG1846	Transcriptional regulator
APS46_RS05770	COG1012	belongs to the aldehyde dehydrogenase family
APS46_RS05775	COG3384	dioxygenase
APS46_RS05785	COG3971	2-oxopent-4-enoate hydratase activity
APS46_RS05830	COG4232	protein-disulfide reductase activity
APS46_RS05835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APS46_RS05835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APS46_RS05840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS46_RS05860	COG3729	General stress protein
APS46_RS05865	COG1309	transcriptional regulator
APS46_RS05890	COG1702	phosphate starvation-inducible protein PhoH
APS46_RS05895	COG1737	Transcriptional regulator
APS46_RS05900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APS46_RS05920	COG2814	Major facilitator Superfamily
APS46_RS05925	COG0673	inositol 2-dehydrogenase activity
APS46_RS05955	COG3381	protein complex oligomerization
APS46_RS06010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS46_RS06030	COG5645	(Lipo)protein
APS46_RS06045	COG1560	Kdo2-lipid A biosynthetic process
APS46_RS06060	COG3038	cytochrome b561
APS46_RS06095	COG2999	glutathione oxidoreductase activity
APS46_RS06105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS46_RS06195	COG1530	ribonuclease E activity
APS46_RS06260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APS46_RS06265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APS46_RS06270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APS46_RS06280	COG0470	DNA polymerase III
APS46_RS06285	COG0084	hydrolase, TatD family'
APS46_RS06295	COG4773	Receptor
APS46_RS06300	COG0537	adenosine 5'-monophosphoramidase activity
APS46_RS06305	COG5633	Lipoprotein
APS46_RS06330	COG1252	NADH dehydrogenase
APS46_RS06335	COG3134	Outer membrane lipoprotein
APS46_RS06340	COG1309	transcriptional regulator
APS46_RS06350	COG1388	LysM domain
APS46_RS06350	COG1376	ErfK ybiS ycfS ynhG family protein
APS46_RS06355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APS46_RS06360	COG4591	ABC-type transport system involved in lipoprotein release permease component
APS46_RS06365	COG1136	(ABC) transporter
APS46_RS06370	COG4591	ABC-type transport system involved in lipoprotein release permease component
APS46_RS06390	COG1177	transmembrane transport
APS46_RS06420	COG2850	peptidyl-arginine hydroxylation
APS46_RS06435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APS46_RS06465	COG0538	isocitrate dehydrogenase activity
APS46_RS06560	COG0071	Belongs to the small heat shock protein (HSP20) family
APS46_RS06575	COG3038	cytochrome b561
APS46_RS06605	COG1124	(ABC) transporter
APS46_RS06610	COG0668	transmembrane transport
APS46_RS06625	COG3443	Belongs to the bacterial solute-binding protein 9 family
APS46_RS06640	COG0789	Transcriptional regulator
APS46_RS06655	COG1605	Chorismate mutase
APS46_RS06665	COG3615	Tellurite resistance protein tehB
APS46_RS06685	COG2261	transglycosylase associated protein
APS46_RS06690	COG3042	response to heat
APS46_RS06700	COG3189	MarR family transcriptional regulator
APS46_RS06705	COG2807	transmembrane transport
APS46_RS06710	COG2207	Transcriptional regulator
APS46_RS06725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APS46_RS06730	COG2199	diguanylate cyclase activity
APS46_RS06740	COG2766	serine protein kinase
APS46_RS06745	COG3713	MltA-interacting MipA family protein
APS46_RS06750	COG0641	radical SAM
APS46_RS06755	COG0656	L-ascorbic acid biosynthetic process
APS46_RS06775	COG3139	Protein of unknown function (DUF1315)
APS46_RS06780	COG1335	isochorismatase
APS46_RS06785	COG0252	asparaginase activity
APS46_RS06790	COG0616	signal peptide processing
APS46_RS06795	COG0778	Nitroreductase
APS46_RS06820	COG0494	nUDIX hydrolase
APS46_RS06855	COG3678	ATP-independent chaperone mediated protein folding
APS46_RS06860	COG0322	excinuclease ABC activity
APS46_RS06870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APS46_RS06875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APS46_RS06880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APS46_RS06885	COG1447	Phosphotransferase system cellobiose-specific component IIA
APS46_RS06890	COG2169	Transcriptional regulator
APS46_RS06890	COG1917	Cupin 2, conserved barrel domain protein
APS46_RS06895	COG1486	melibiose metabolic process
APS46_RS06905	COG0753	catalase activity
APS46_RS06915	COG1823	symporter activity
APS46_RS06920	COG1988	membrane-bound metal-dependent
APS46_RS06925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APS46_RS06935	COG3001	Fructosamine kinase
APS46_RS06945	COG1105	Belongs to the carbohydrate kinase PfkB family
APS46_RS06950	COG3137	Salt-induced outer membrane protein
APS46_RS07020	COG0386	Belongs to the glutathione peroxidase family
APS46_RS07030	COG0791	NLP P60 protein
APS46_RS07045	COG4256	Hemin uptake protein
APS46_RS07060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APS46_RS07060	COG0574	Belongs to the PEP-utilizing enzyme family
APS46_RS07065	COG0318	PFAM AMP-dependent synthetase and ligase
APS46_RS07070	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
APS46_RS07075	COG0644	oxidoreductase
APS46_RS07080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APS46_RS07085	COG2086	electron transfer activity
APS46_RS07090	COG2207	Transcriptional regulator
APS46_RS07090	COG1917	Cupin 2, conserved barrel domain protein
APS46_RS07095	COG1960	acyl-CoA dehydrogenase activity
APS46_RS07100	COG4670	ketone body catabolic process
APS46_RS07115	COG2271	Major facilitator Superfamily
APS46_RS07120	COG0738	Major facilitator superfamily
APS46_RS07135	COG0628	permease
APS46_RS07140	COG0247	lactate metabolic process
APS46_RS07140	COG0277	FAD linked oxidase domain protein
APS46_RS07145	COG2050	protein possibly involved in aromatic compounds catabolism
APS46_RS07155	COG1823	symporter activity
APS46_RS07160	COG0316	Belongs to the HesB IscA family
APS46_RS07165	COG0719	Fe-S assembly protein
APS46_RS07170	COG0396	ATPase activity
APS46_RS07175	COG0719	Fe-S assembly protein
APS46_RS07190	COG1376	ErfK ybiS ycfS ynhG family protein
APS46_RS07195	COG4238	major outer membrane lipoprotein
APS46_RS07215	COG0531	amino acid
APS46_RS07220	COG2267	carboxylic ester hydrolase activity
APS46_RS07230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS46_RS07265	COG3272	Protein of unknown function (DUF1722)
APS46_RS07270	COG0789	Transcriptional regulator
APS46_RS07450	COG0307	riboflavin synthase, alpha
APS46_RS07455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APS46_RS07460	COG2814	Major facilitator Superfamily
APS46_RS07465	COG0583	DNA-binding transcription factor activity
APS46_RS07480	COG0791	NLP P60 protein
APS46_RS07485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APS46_RS07500	COG1902	pentaerythritol trinitrate reductase activity
APS46_RS07505	COG1309	transcriptional regulator
APS46_RS07510	COG3313	Fe-S protein
APS46_RS07515	COG4989	oxidoreductase activity
APS46_RS07530	COG1566	PFAM secretion protein HlyD family protein
APS46_RS07555	COG3895	Periplasmic Protein
APS46_RS07575	COG0625	glutathione transferase activity
APS46_RS07585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APS46_RS07635	COG0673	inositol 2-dehydrogenase activity
APS46_RS07645	COG5339	Protein conserved in bacteria
APS46_RS07670	COG2205	protein histidine kinase activity
APS46_RS07675	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APS46_RS07680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APS46_RS07690	COG0745	RESPONSE REGULATOR receiver
APS46_RS07695	COG3136	membrane protein required for alginate biosynthesis
APS46_RS07700	COG0531	amino acid
APS46_RS07710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APS46_RS07715	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APS46_RS07720	COG0628	permease
APS46_RS07735	COG3591	Belongs to the peptidase S1B family
APS46_RS07745	COG2814	Major facilitator Superfamily
APS46_RS07750	COG0583	DNA-binding transcription factor activity
APS46_RS07755	COG1940	carbohydrate kinase activity
APS46_RS07795	COG3302	dmso reductase anchor subunit
APS46_RS07800	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS07805	COG0243	molybdopterin cofactor binding
APS46_RS07810	COG0243	molybdopterin cofactor binding
APS46_RS07825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS46_RS07845	COG1063	alcohol dehydrogenase
APS46_RS07850	COG0477	Major facilitator Superfamily
APS46_RS07855	COG0246	Mannitol dehydrogenase
APS46_RS07865	COG1802	Transcriptional regulator
APS46_RS07870	COG4221	oxidoreductase activity
APS46_RS07880	COG3729	General stress protein
APS46_RS07885	COG1546	Belongs to the CinA family
APS46_RS07890	COG3111	PFAM Bacterial OB fold (BOF) protein
APS46_RS07900	COG2814	Major facilitator Superfamily
APS46_RS07935	COG0583	DNA-binding transcription factor activity
APS46_RS07940	COG1012	belongs to the aldehyde dehydrogenase family
APS46_RS07955	COG3781	membrane
APS46_RS07980	COG1773	rubredoxin
APS46_RS08005	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APS46_RS08010	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APS46_RS08020	COG2186	Transcriptional regulator
APS46_RS08025	COG1063	alcohol dehydrogenase
APS46_RS08030	COG2271	Major facilitator Superfamily
APS46_RS08055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APS46_RS08060	COG0251	oxidation-reduction process
APS46_RS08110	COG1609	Transcriptional regulator
APS46_RS08115	COG1757	Na H antiporter
APS46_RS08120	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APS46_RS08135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APS46_RS08150	COG1764	response to oxidative stress
APS46_RS08170	COG1064	alcohol dehydrogenase
APS46_RS08175	COG2864	formate dehydrogenase
APS46_RS08180	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS08185	COG3383	formate dehydrogenase (NAD+) activity
APS46_RS08185	COG0243	molybdopterin cofactor binding
APS46_RS08190	COG0243	molybdopterin cofactor binding
APS46_RS08190	COG3383	formate dehydrogenase (NAD+) activity
APS46_RS08225	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APS46_RS08230	COG1140	nitrate reductase beta subunit
APS46_RS08235	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APS46_RS08240	COG2181	nitrate reductase activity
APS46_RS08275	COG4772	TonB-dependent receptor
APS46_RS08280	COG1802	Transcriptional regulator
APS46_RS08285	COG2130	NADP-dependent
APS46_RS08295	COG3238	Protein conserved in bacteria
APS46_RS08330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APS46_RS08335	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APS46_RS08360	COG0826	peptidase U32
APS46_RS08365	COG1396	sequence-specific DNA binding
APS46_RS08370	COG3135	benzoate transporter
APS46_RS08380	COG0500	methyltransferase
APS46_RS08385	COG1275	C4-dicarboxylate transporter malic acid transport protein
APS46_RS08390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APS46_RS08395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS46_RS08405	COG3414	Phosphotransferase system galactitol-specific IIB component
APS46_RS08410	COG3775	system Galactitol-specific IIC component
APS46_RS08415	COG0434	BtpA family
APS46_RS08420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS08425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APS46_RS08430	COG1349	DNA-binding transcription factor activity
APS46_RS08440	COG1304	FMN binding
APS46_RS08445	COG2353	YceI-like domain
APS46_RS08455	COG2272	Belongs to the type-B carboxylesterase lipase family
APS46_RS08460	COG5383	Protein conserved in bacteria
APS46_RS08465	COG0583	DNA-binding transcription factor activity
APS46_RS08470	COG0840	transmembrane signaling receptor activity
APS46_RS08500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS46_RS08505	COG0765	amino acid transport
APS46_RS08515	COG0765	amino acid transport
APS46_RS08525	COG0500	methyltransferase
APS46_RS08530	COG3038	cytochrome b561
APS46_RS08535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APS46_RS08540	COG1643	Atp-dependent helicase
APS46_RS08555	COG3784	Protein of unknown function (DUF1318)
APS46_RS08565	COG2911	Protein conserved in bacteria
APS46_RS08570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APS46_RS08575	COG3187	Heat shock protein
APS46_RS08580	COG3042	response to heat
APS46_RS08590	COG0674	pyruvate-flavodoxin oxidoreductase activity
APS46_RS08590	COG1013	pyruvate-flavodoxin oxidoreductase activity
APS46_RS08590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APS46_RS08590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS46_RS08605	COG2076	Multidrug Resistance protein
APS46_RS08620	COG0513	Belongs to the DEAD box helicase family
APS46_RS08630	COG0840	transmembrane signaling receptor activity
APS46_RS08635	COG2840	Smr protein MutS2
APS46_RS08655	COG3182	Iron-regulated membrane protein
APS46_RS08660	COG0668	transmembrane transport
APS46_RS08680	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APS46_RS08715	COG1309	transcriptional regulator
APS46_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS08725	COG0656	L-ascorbic acid biosynthetic process
APS46_RS08730	COG0583	DNA-binding transcription factor activity
APS46_RS08740	COG4166	transmembrane transport
APS46_RS08745	COG2866	Carboxypeptidase
APS46_RS08750	COG4948	Mandelate Racemase Muconate Lactonizing
APS46_RS08770	COG3106	COG3106 Predicted ATPase
APS46_RS08775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APS46_RS08785	COG1983	PspC domain protein
APS46_RS08795	COG1842	Phage shock protein A
APS46_RS08800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
APS46_RS08855	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APS46_RS08855	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APS46_RS08865	COG5001	Diguanylate cyclase
APS46_RS08875	COG1349	DNA-binding transcription factor activity
APS46_RS08895	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APS46_RS08900	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APS46_RS08905	COG0671	phosphoesterase, PA-phosphatase related
APS46_RS08940	COG0616	signal peptide processing
APS46_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS08960	COG0009	L-threonylcarbamoyladenylate synthase
APS46_RS08980	COG0134	indole-3-glycerol-phosphate synthase activity
APS46_RS08980	COG0135	phosphoribosylanthranilate isomerase activity
APS46_RS08995	COG3729	General stress protein
APS46_RS09000	COG3685	Protein conserved in bacteria
APS46_RS09005	COG3685	Protein conserved in bacteria
APS46_RS09010	COG3546	catalase activity
APS46_RS09020	COG0727	PFAM Uncharacterised protein family (UPF0153)
APS46_RS09045	COG2350	Protein conserved in bacteria
APS46_RS09060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APS46_RS09090	COG2095	MarC family integral membrane protein
APS46_RS09095	COG1012	belongs to the aldehyde dehydrogenase family
APS46_RS09095	COG1454	alcohol dehydrogenase
APS46_RS09110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APS46_RS09115	COG0745	RESPONSE REGULATOR receiver
APS46_RS09120	COG1752	Esterase of the alpha-beta hydrolase superfamily
APS46_RS09130	COG0788	formyltetrahydrofolate deformylase activity
APS46_RS09175	COG2181	nitrate reductase activity
APS46_RS09180	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APS46_RS09185	COG1140	nitrate reductase beta subunit
APS46_RS09190	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APS46_RS09195	COG2223	nitrite transmembrane transporter activity
APS46_RS09200	COG3850	Histidine kinase
APS46_RS09205	COG2197	response regulator
APS46_RS09210	COG4932	domain protein
APS46_RS09215	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APS46_RS09220	COG4572	Cation transport regulator
APS46_RS09225	COG0387	Pfam Sodium calcium exchanger
APS46_RS09275	COG0659	secondary active sulfate transmembrane transporter activity
APS46_RS09290	COG0012	GTP binding
APS46_RS09300	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APS46_RS09310	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
APS46_RS09315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APS46_RS09320	COG1999	signal sequence binding
APS46_RS09325	COG1773	rubredoxin
APS46_RS09330	COG1271	oxidase subunit
APS46_RS09335	COG1294	oxidase, subunit
APS46_RS09345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APS46_RS09370	COG1619	proteins homologs of microcin C7 resistance protein MccF
APS46_RS09390	COG2719	SpoVR family
APS46_RS09430	COG0179	Fumarylacetoacetate (FAA) hydrolase
APS46_RS09445	COG2894	cell division
APS46_RS09455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APS46_RS09465	COG3065	identical protein binding
APS46_RS09475	COG1199	ATP-dependent helicase activity
APS46_RS09480	COG0251	oxidation-reduction process
APS46_RS09500	COG1760	l-serine dehydratase
APS46_RS09505	COG2200	EAL domain
APS46_RS09510	COG1253	flavin adenine dinucleotide binding
APS46_RS09520	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS09520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APS46_RS09525	COG3715	PTS system
APS46_RS09530	COG3716	PTS system mannose fructose sorbose family IID component
APS46_RS09545	COG2226	methyltransferase
APS46_RS09550	COG0768	penicillin binding
APS46_RS09580	COG1414	Transcriptional regulator
APS46_RS09585	COG2814	Major facilitator Superfamily
APS46_RS09605	COG1956	GAF domain-containing protein
APS46_RS09610	COG2995	paraquat-inducible protein a
APS46_RS09615	COG3008	intermembrane lipid transfer
APS46_RS09650	COG5562	phage envelope protein
APS46_RS09660	COG0454	-acetyltransferase
APS46_RS09735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APS46_RS09755	COG1276	copper resistance
APS46_RS09760	COG2372	response to copper ion
APS46_RS09770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APS46_RS09775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APS46_RS09780	COG1770	oligopeptidase
APS46_RS09785	COG2979	Protein of unknown function (DUF533)
APS46_RS09795	COG3141	response to X-ray
APS46_RS09805	COG0800	Aldolase
APS46_RS09810	COG0129	dihydroxy-acid dehydratase activity
APS46_RS09815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APS46_RS09820	COG1737	Transcriptional regulator
APS46_RS09830	COG1560	Kdo2-lipid A biosynthetic process
APS46_RS09835	COG0739	heme binding
APS46_RS09840	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APS46_RS09850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APS46_RS09885	COG0494	nUDIX hydrolase
APS46_RS09895	COG1335	isochorismatase
APS46_RS09900	COG1801	Protein of unknown function DUF72
APS46_RS09905	COG3788	relative of glutathione S-transferase, MAPEG superfamily
APS46_RS09925	COG3102	Protein conserved in bacteria
APS46_RS09940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APS46_RS10040	COG1528	Iron-storage protein
APS46_RS10055	COG1528	Iron-storage protein
APS46_RS10065	COG0814	amino acid
APS46_RS10070	COG3012	SEC-C Motif Domain Protein
APS46_RS10070	COG3318	Belongs to the UPF0149 family
APS46_RS10115	COG2197	response regulator
APS46_RS10130	COG2197	response regulator
APS46_RS10135	COG1126	abc transporter atp-binding protein
APS46_RS10140	COG0765	amino acid transport
APS46_RS10150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS46_RS10205	COG0425	Belongs to the sulfur carrier protein TusA family
APS46_RS10310	COG5475	Uncharacterized small protein (DUF2158)
APS46_RS10315	COG2354	Protein conserved in bacteria
APS46_RS10320	COG0697	spore germination
APS46_RS10325	COG3727	T/G mismatch-specific endonuclease activity
APS46_RS10330	COG0270	DNA (cytosine-5-)-methyltransferase activity
APS46_RS10335	COG1418	mRNA catabolic process
APS46_RS10345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APS46_RS10385	COG0582	viral genome integration into host DNA
APS46_RS10425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APS46_RS10455	COG0534	Mate efflux family protein
APS46_RS10495	COG1122	ATPase activity
APS46_RS10625	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APS46_RS10640	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
APS46_RS10655	COG1454	alcohol dehydrogenase
APS46_RS10655	COG1012	belongs to the aldehyde dehydrogenase family
APS46_RS10660	COG4656	Part of a membrane complex involved in electron transport
APS46_RS10695	COG1289	transmembrane transporter activity
APS46_RS10730	COG2925	Exonuclease
APS46_RS10735	COG0531	amino acid
APS46_RS10740	COG0583	DNA-binding transcription factor activity
APS46_RS10745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS46_RS10900	COG2327	Polysaccharide pyruvyl transferase
APS46_RS10905	COG2244	polysaccharide biosynthetic process
APS46_RS10910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APS46_RS10925	COG0297	glycogen (starch) synthase activity
APS46_RS10935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS46_RS10940	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
APS46_RS10945	COG0110	maltose O-acetyltransferase activity
APS46_RS10950	COG1216	Glycosyl transferase, family 2
APS46_RS10960	COG0438	transferase activity, transferring glycosyl groups
APS46_RS10965	COG1045	serine acetyltransferase
APS46_RS10970	COG0463	Glycosyl transferase, family 2
APS46_RS10990	COG1253	flavin adenine dinucleotide binding
APS46_RS10995	COG2982	Protein involved in outer membrane biogenesis
APS46_RS11010	COG5001	Diguanylate cyclase
APS46_RS11010	COG5002	protein histidine kinase activity
APS46_RS11010	COG3447	MASE1 domain protein
APS46_RS11015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APS46_RS11020	COG0443	Heat shock 70 kDa protein
APS46_RS11045	COG2205	protein histidine kinase activity
APS46_RS11050	COG0745	RESPONSE REGULATOR receiver
APS46_RS11070	COG0826	peptidase U32
APS46_RS11100	COG1830	Aldolase
APS46_RS11105	COG2211	Major facilitator Superfamily
APS46_RS11110	COG1397	ADP-ribosylglycohydrolase
APS46_RS11115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS46_RS11120	COG2188	Transcriptional regulator
APS46_RS11135	COG5455	response to cobalt ion
APS46_RS11140	COG3539	Fimbrial protein
APS46_RS11145	COG3188	usher protein
APS46_RS11150	COG3121	Chaperone
APS46_RS11175	COG4808	Protein conserved in bacteria
APS46_RS11185	COG4807	Protein conserved in bacteria
APS46_RS11195	COG3275	phosphorelay sensor kinase activity
APS46_RS11210	COG1174	glycine betaine transport
APS46_RS11215	COG1125	glycine betaine transport
APS46_RS11220	COG1174	glycine betaine transport
APS46_RS11225	COG1732	Glycine betaine
APS46_RS11235	COG0277	FAD linked oxidase domain protein
APS46_RS11240	COG1686	Belongs to the peptidase S11 family
APS46_RS11250	COG0586	Pfam SNARE associated Golgi protein
APS46_RS11255	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS11260	COG1538	Outer membrane efflux protein
APS46_RS11265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APS46_RS11270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS46_RS11275	COG0625	glutathione transferase activity
APS46_RS11290	COG2271	Major facilitator Superfamily
APS46_RS11305	COG1346	cytolysis
APS46_RS11315	COG2949	membrane
APS46_RS11325	COG0493	'glutamate synthase
APS46_RS11355	COG2311	Membrane
APS46_RS11375	COG1760	l-serine dehydratase
APS46_RS11380	COG0560	Phosphoserine phosphatase
APS46_RS11385	COG2271	Major facilitator Superfamily
APS46_RS11390	COG4771	TonB-dependent receptor
APS46_RS11395	COG0833	amino acid
APS46_RS11400	COG0583	DNA-binding transcription factor activity
APS46_RS11405	COG2855	membrane
APS46_RS11415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APS46_RS11415	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APS46_RS11415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APS46_RS11420	COG1105	Belongs to the carbohydrate kinase PfkB family
APS46_RS11455	COG0523	cobalamin synthesis protein
APS46_RS11460	COG0671	phosphoesterase, PA-phosphatase related
APS46_RS11465	COG0791	NLP P60 protein
APS46_RS11470	COG2200	EAL domain
APS46_RS11475	COG4166	transmembrane transport
APS46_RS11480	COG4174	ABC transporter (Permease)
APS46_RS11485	COG4239	(ABC) transporter, permease
APS46_RS11490	COG4172	Belongs to the ABC transporter superfamily
APS46_RS11505	COG2814	Major facilitator Superfamily
APS46_RS11515	COG1061	Type III restriction enzyme res subunit
APS46_RS11600	COG1403	HNH endonuclease
APS46_RS11620	COG5301	cellulose 1,4-beta-cellobiosidase activity
APS46_RS11635	COG2197	response regulator
APS46_RS11640	COG3088	subunit of a heme lyase
APS46_RS11640	COG4235	cytochrome complex assembly
APS46_RS11650	COG1138	Cytochrome C-type biogenesis protein
APS46_RS11660	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS46_RS11665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS46_RS11670	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS46_RS11675	COG4133	protoheme IX ABC transporter activity
APS46_RS11680	COG3005	denitrification pathway
APS46_RS11685	COG3043	anaerobic respiration
APS46_RS11690	COG0348	domain, Protein
APS46_RS11695	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS11705	COG3062	negative regulation of establishment of protein localization
APS46_RS11710	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS46_RS11710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS46_RS11720	COG4615	Cyclic peptide transporter
APS46_RS11745	COG0642	Histidine kinase
APS46_RS11745	COG2198	Histidine kinase
APS46_RS11765	COG4948	Mandelate Racemase Muconate Lactonizing
APS46_RS11795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APS46_RS11800	COG2814	Major facilitator Superfamily
APS46_RS11805	COG0583	DNA-binding transcription factor activity
APS46_RS11810	COG0584	glycerophosphoryl diester phosphodiesterase
APS46_RS11815	COG2271	Major facilitator Superfamily
APS46_RS11820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APS46_RS11830	COG0247	lactate metabolic process
APS46_RS11850	COG2271	Major facilitator Superfamily
APS46_RS11860	COG1414	Transcriptional regulator
APS46_RS11950	COG1169	isochorismate synthase
APS46_RS11955	COG4575	ribosome binding
APS46_RS11960	COG2153	protein acetylation
APS46_RS11970	COG0784	Response regulator, receiver
APS46_RS11970	COG0835	chemotaxis
APS46_RS11980	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS46_RS11985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APS46_RS11995	COG0839	Belongs to the complex I subunit 6 family
APS46_RS12045	COG0583	DNA-binding transcription factor activity
APS46_RS12050	COG0436	Aminotransferase
APS46_RS12060	COG0471	metal ion transport
APS46_RS12060	COG0490	domain, Protein
APS46_RS12065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APS46_RS12090	COG1288	antiporter activity
APS46_RS12095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APS46_RS12100	COG3959	Transketolase, thiamine diphosphate binding domain
APS46_RS12105	COG3037	sugar-specific permease SgaT UlaA
APS46_RS12115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS12125	COG1609	Transcriptional regulator
APS46_RS12135	COG0622	Phosphoesterase
APS46_RS12140	COG0625	glutathione transferase activity
APS46_RS12145	COG0625	glutathione transferase activity
APS46_RS12150	COG1090	epimerase
APS46_RS12185	COG0833	amino acid
APS46_RS12190	COG3457	Alanine racemase
APS46_RS12195	COG0531	amino acid
APS46_RS12205	COG3829	transcription factor binding
APS46_RS12210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APS46_RS12215	COG1286	toxin biosynthetic process
APS46_RS12220	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
APS46_RS12225	COG0285	dihydrofolate synthase activity
APS46_RS12235	COG0586	Pfam SNARE associated Golgi protein
APS46_RS12245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APS46_RS12270	COG3423	Transcriptional regulator
APS46_RS12290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APS46_RS12305	COG3101	peptidyl-lysine hydroxylation
APS46_RS12310	COG0730	response to heat
APS46_RS12335	COG2062	phosphohistidine phosphatase, SixA
APS46_RS12350	COG3691	Protein conserved in bacteria
APS46_RS12365	COG2116	formate transmembrane transporter activity
APS46_RS12375	COG0582	viral genome integration into host DNA
APS46_RS12470	COG1560	Kdo2-lipid A biosynthetic process
APS46_RS12485	COG0436	Aminotransferase
APS46_RS12500	COG3961	Belongs to the TPP enzyme family
APS46_RS12505	COG0667	Aldo Keto reductase
APS46_RS12520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APS46_RS12525	COG2199	diguanylate cyclase activity
APS46_RS12525	COG2200	EAL domain
APS46_RS12540	COG3415	Transposase
APS46_RS12545	COG3415	Transposase
APS46_RS12575	COG0583	DNA-binding transcription factor activity
APS46_RS12585	COG2211	Major facilitator Superfamily
APS46_RS12590	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APS46_RS12600	COG0583	DNA-binding transcription factor activity
APS46_RS12605	COG0385	Bile acid
APS46_RS12610	COG3530	Putative quorum-sensing-regulated virulence factor
APS46_RS12640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS12695	COG4208	sulfate ABC transporter
APS46_RS12715	COG2837	iron assimilation
APS46_RS12845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APS46_RS12855	COG5342	invasion associated locus B
APS46_RS12870	COG0493	'glutamate synthase
APS46_RS12870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS46_RS12875	COG3850	Histidine kinase
APS46_RS12880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS46_RS12885	COG1393	Belongs to the ArsC family
APS46_RS12905	COG2321	neutral zinc metallopeptidase
APS46_RS12915	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
APS46_RS12925	COG2716	regulation of RNA biosynthetic process
APS46_RS12930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APS46_RS12935	COG1929	Belongs to the glycerate kinase type-1 family
APS46_RS12940	COG0628	permease
APS46_RS12950	COG1393	Belongs to the ArsC family
APS46_RS12960	COG2233	PERMEase
APS46_RS12975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APS46_RS12990	COG2200	EAL domain
APS46_RS13010	COG2801	Transposase and inactivated derivatives
APS46_RS13020	COG0517	IMP dehydrogenase activity
APS46_RS13020	COG0516	GMP reductase activity
APS46_RS13055	COG1645	bacterial-type flagellum-dependent swarming motility
APS46_RS13070	COG2976	Protein conserved in bacteria
APS46_RS13110	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS13115	COG0243	molybdopterin cofactor binding
APS46_RS13120	COG4953	penicillin-binding protein 1C
APS46_RS13125	COG2373	Large extracellular alpha-helical protein
APS46_RS13130	COG2897	thiosulfate sulfurtransferase activity
APS46_RS13150	COG2975	iron-sulfur cluster assembly
APS46_RS13155	COG0633	Ferredoxin
APS46_RS13175	COG0822	iron-sulfur transferase activity
APS46_RS13220	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APS46_RS13230	COG3711	transcriptional antiterminator
APS46_RS13235	COG2814	Major facilitator Superfamily
APS46_RS13250	COG3710	Transcriptional regulator
APS46_RS13255	COG0531	amino acid
APS46_RS13265	COG3104	oligopeptide transport
APS46_RS13270	COG0347	Belongs to the P(II) protein family
APS46_RS13275	COG2204	response regulator
APS46_RS13280	COG3170	Tfp pilus assembly protein FimV
APS46_RS13285	COG2205	protein histidine kinase activity
APS46_RS13310	COG0560	Phosphoserine phosphatase
APS46_RS13315	COG1263	PTS System
APS46_RS13315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APS46_RS13325	COG1737	Transcriptional regulator
APS46_RS13330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APS46_RS13335	COG2223	nitrite transmembrane transporter activity
APS46_RS13340	COG0583	DNA-binding transcription factor activity
APS46_RS13345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS46_RS13385	COG3086	response to oxidative stress
APS46_RS13415	COG0513	Belongs to the DEAD box helicase family
APS46_RS13420	COG0583	DNA-binding transcription factor activity
APS46_RS13440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APS46_RS13445	COG3118	belongs to the thioredoxin family
APS46_RS13450	COG3148	PFAM DTW domain containing protein
APS46_RS13460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS46_RS13465	COG5544	Lipoprotein
APS46_RS13470	COG0477	Major facilitator Superfamily
APS46_RS13500	COG0542	response to heat
APS46_RS13515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APS46_RS13520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APS46_RS13525	COG1605	Chorismate mutase
APS46_RS13525	COG0077	Prephenate dehydratase
APS46_RS13535	COG0287	Prephenate dehydrogenase
APS46_RS13535	COG1605	Chorismate mutase
APS46_RS13550	COG2199	diguanylate cyclase activity
APS46_RS13575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APS46_RS13580	COG4137	Cytochrome C assembly protein
APS46_RS13585	COG4536	flavin adenine dinucleotide binding
APS46_RS13605	COG0497	DNA recombination
APS46_RS13620	COG2867	negative regulation of translational initiation
APS46_RS13645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS46_RS13655	COG0582	viral genome integration into host DNA
APS46_RS13660	COG0582	viral genome integration into host DNA
APS46_RS13690	COG4133	protoheme IX ABC transporter activity
APS46_RS13705	COG3423	Transcriptional regulator
APS46_RS13725	COG0673	inositol 2-dehydrogenase activity
APS46_RS13735	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APS46_RS13740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APS46_RS13750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APS46_RS13750	COG1263	PTS System
APS46_RS13750	COG2190	(PTS) system
APS46_RS13785	COG2801	Transposase and inactivated derivatives
APS46_RS13795	COG2963	transposase activity
APS46_RS13815	COG2801	Transposase and inactivated derivatives
APS46_RS13840	COG1132	(ABC) transporter
APS46_RS13850	COG2819	hydrolase of the alpha beta superfamily
APS46_RS13870	COG2990	Protein conserved in bacteria
APS46_RS13885	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
APS46_RS13925	COG0579	oxidoreductase
APS46_RS13930	COG1012	belongs to the aldehyde dehydrogenase family
APS46_RS13935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APS46_RS13940	COG1113	amino acid transport
APS46_RS13945	COG1802	Transcriptional regulator
APS46_RS13950	COG1652	LysM domain
APS46_RS13955	COG0401	homolog of Blt101
APS46_RS13960	COG0640	Transcriptional regulator
APS46_RS13965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APS46_RS13990	COG4575	ribosome binding
APS46_RS14000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APS46_RS14045	COG2814	Major facilitator Superfamily
APS46_RS14050	COG1846	Transcriptional regulator
APS46_RS14055	COG1566	PFAM secretion protein HlyD family protein
APS46_RS14060	COG2814	Major facilitator Superfamily
APS46_RS14080	COG1238	metal cluster binding
APS46_RS14085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APS46_RS14115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APS46_RS14135	COG1546	Belongs to the CinA family
APS46_RS14140	COG2951	lytic endotransglycosylase activity
APS46_RS14145	COG3730	PTS system glucitol sorbitol-specific
APS46_RS14150	COG3732	PTS system glucitol sorbitol-specific
APS46_RS14160	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS14165	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS14175	COG1349	DNA-binding transcription factor activity
APS46_RS14180	COG0517	IMP dehydrogenase activity
APS46_RS14180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APS46_RS14200	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APS46_RS14205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS46_RS14215	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APS46_RS14225	COG3260	NADH ubiquinone oxidoreductase 20
APS46_RS14230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS46_RS14235	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
APS46_RS14235	COG3261	NADH dehydrogenase
APS46_RS14240	COG0650	Formate hydrogenlyase subunit 4
APS46_RS14245	COG0651	ATP synthesis coupled electron transport
APS46_RS14250	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS46_RS14265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APS46_RS14270	COG0298	carbon dioxide binding
APS46_RS14275	COG0409	Hydrogenase expression formation protein
APS46_RS14280	COG0309	Hydrogenase expression formation protein (HypE)
APS46_RS14300	COG1121	(ABC) transporter
APS46_RS14305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APS46_RS14310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APS46_RS14395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APS46_RS14485	COG2207	Transcriptional regulator
APS46_RS14545	COG0477	Major facilitator Superfamily
APS46_RS14555	COG2610	gluconate transmembrane transporter activity
APS46_RS14560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS46_RS14565	COG3622	Belongs to the hyi family
APS46_RS14570	COG0235	Class ii aldolase
APS46_RS14580	COG2084	Dehydrogenase
APS46_RS14585	COG1349	DNA-binding transcription factor activity
APS46_RS14595	COG0163	prenyltransferase activity
APS46_RS14600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APS46_RS14670	COG2234	aminopeptidase activity
APS46_RS14675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APS46_RS14680	COG1518	maintenance of DNA repeat elements
APS46_RS14695	COG1857	crispr-associated protein
APS46_RS14710	COG1203	CRISPR-associated helicase, Cas3
APS46_RS14730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APS46_RS14735	COG0720	synthase
APS46_RS14740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APS46_RS14740	COG0321	lipoyl(octanoyl) transferase activity
APS46_RS14745	COG0602	queuosine metabolic process
APS46_RS14760	COG3956	TIGRFAM MazG family protein
APS46_RS14765	COG3539	Fimbrial protein
APS46_RS14770	COG3188	usher protein
APS46_RS14775	COG3121	Chaperone
APS46_RS14780	COG3539	Fimbrial protein
APS46_RS14815	COG3609	addiction module antidote protein, CC2985 family
APS46_RS14820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APS46_RS14830	COG2205	protein histidine kinase activity
APS46_RS14830	COG3437	response regulator, receiver
APS46_RS14830	COG4999	Histidine kinase
APS46_RS14830	COG3850	Histidine kinase
APS46_RS14835	COG1929	Belongs to the glycerate kinase type-1 family
APS46_RS14840	COG4948	Mandelate Racemase Muconate Lactonizing
APS46_RS14845	COG4948	Mandelate Racemase Muconate Lactonizing
APS46_RS14850	COG2271	Major facilitator Superfamily
APS46_RS14855	COG0716	FMN binding
APS46_RS14865	COG3098	single-species biofilm formation
APS46_RS14885	COG1611	Belongs to the LOG family
APS46_RS14890	COG0814	amino acid
APS46_RS14895	COG1760	l-serine dehydratase
APS46_RS14905	COG1454	alcohol dehydrogenase
APS46_RS14910	COG0235	Class ii aldolase
APS46_RS14915	COG0738	Major facilitator superfamily
APS46_RS14935	COG1349	DNA-binding transcription factor activity
APS46_RS14945	COG2363	Small membrane protein
APS46_RS14950	COG0583	DNA-binding transcription factor activity
APS46_RS14960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APS46_RS14965	COG2166	iron-sulfur cluster assembly
APS46_RS14970	COG2962	Rard protein
APS46_RS14975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APS46_RS14980	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APS46_RS14995	COG0860	N-Acetylmuramoyl-L-alanine amidase
APS46_RS15005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APS46_RS15010	COG1074	ATP-dependent DNA helicase activity
APS46_RS15020	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APS46_RS15025	COG4967	type IV pilus modification protein PilV
APS46_RS15035	COG4795	General secretion pathway protein
APS46_RS15040	COG2165	general secretion pathway protein
APS46_RS15080	COG0861	Integral membrane protein TerC family
APS46_RS15090	COG0667	Aldo Keto reductase
APS46_RS15110	COG1609	Transcriptional regulator
APS46_RS15120	COG0583	DNA-binding transcription factor activity
APS46_RS15125	COG1794	racemase activity, acting on amino acids and derivatives
APS46_RS15130	COG2814	Major facilitator Superfamily
APS46_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS15145	COG0183	Belongs to the thiolase family
APS46_RS15160	COG0814	amino acid
APS46_RS15195	COG3188	usher protein
APS46_RS15215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APS46_RS15220	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS15225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APS46_RS15230	COG3775	system Galactitol-specific IIC component
APS46_RS15235	COG3414	Phosphotransferase system galactitol-specific IIB component
APS46_RS15240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS15245	COG1349	DNA-binding transcription factor activity
APS46_RS15250	COG0698	ribose 5-phosphate isomerase
APS46_RS15255	COG3775	system Galactitol-specific IIC component
APS46_RS15260	COG3414	Phosphotransferase system galactitol-specific IIB component
APS46_RS15265	COG2213	PTS system mannitol-specific
APS46_RS15265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS15285	COG0582	viral genome integration into host DNA
APS46_RS15295	COG4942	peptidase
APS46_RS15355	COG1272	protein, Hemolysin III
APS46_RS15365	COG2723	6-phospho-beta-galactosidase activity
APS46_RS15390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS46_RS15395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS46_RS15400	COG0006	proline dipeptidase activity
APS46_RS15420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APS46_RS15425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APS46_RS15440	COG2968	Membrane
APS46_RS15450	COG0668	transmembrane transport
APS46_RS15455	COG0191	fructose-bisphosphate aldolase activity
APS46_RS15485	COG1122	ATPase activity
APS46_RS15490	COG1122	ATPase activity
APS46_RS15495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APS46_RS15500	COG0501	Belongs to the peptidase M48B family
APS46_RS15510	COG2267	carboxylic ester hydrolase activity
APS46_RS15515	COG2731	YhcH YjgK YiaL family protein
APS46_RS15520	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APS46_RS15525	COG1063	alcohol dehydrogenase
APS46_RS15530	COG0246	Mannitol dehydrogenase
APS46_RS15535	COG4948	Mandelate Racemase Muconate Lactonizing
APS46_RS15540	COG2186	Transcriptional regulator
APS46_RS15550	COG1166	arginine decarboxylase activity
APS46_RS15570	COG2814	Major facilitator Superfamily
APS46_RS15580	COG2356	endonuclease I
APS46_RS15585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APS46_RS15610	COG2805	Type II/IV secretion system protein
APS46_RS15615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APS46_RS15620	COG0762	integral membrane protein
APS46_RS15635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APS46_RS15645	COG0252	asparaginase activity
APS46_RS15655	COG3171	Protein conserved in bacteria
APS46_RS15680	COG2211	Major facilitator Superfamily
APS46_RS15685	COG1982	Orn Lys Arg decarboxylase major
APS46_RS15695	COG1811	Na channel or pump
APS46_RS15710	COG0427	acetyl-CoA hydrolase
APS46_RS15715	COG2030	dehydratase
APS46_RS15720	COG2301	Belongs to the HpcH HpaI aldolase family
APS46_RS15750	COG0531	amino acid
APS46_RS15760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS46_RS15765	COG1012	belongs to the aldehyde dehydrogenase family
APS46_RS15790	COG2271	Major facilitator Superfamily
APS46_RS15800	COG0246	Mannitol dehydrogenase
APS46_RS15815	COG0754	glutathionylspermidine amidase activity
APS46_RS15820	COG0625	glutathione transferase activity
APS46_RS15830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APS46_RS15835	COG0298	carbon dioxide binding
APS46_RS15845	COG1773	rubredoxin
APS46_RS15850	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APS46_RS15855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APS46_RS15860	COG5557	Pfam Polysulphide reductase, NrfD
APS46_RS15865	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS15870	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APS46_RS15880	COG0840	transmembrane signaling receptor activity
APS46_RS15905	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS15910	COG0848	biopolymer transport protein
APS46_RS15935	COG2207	Transcriptional regulator
APS46_RS15940	COG1979	alcohol dehydrogenase
APS46_RS15950	COG0471	metal ion transport
APS46_RS16000	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APS46_RS16005	COG3111	PFAM Bacterial OB fold (BOF) protein
APS46_RS16020	COG2249	NAD(P)H dehydrogenase (quinone) activity
APS46_RS16025	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
APS46_RS16035	COG3150	esterase
APS46_RS16040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APS46_RS16045	COG3151	Protein conserved in bacteria
APS46_RS16050	COG0494	nUDIX hydrolase
APS46_RS16065	COG0754	glutathionylspermidine amidase activity
APS46_RS16070	COG3384	dioxygenase
APS46_RS16115	COG1585	Membrane protein implicated in regulation of membrane protease activity
APS46_RS16120	COG2268	Band 7 protein
APS46_RS16135	COG3025	triphosphatase activity
APS46_RS16140	COG4991	sh3 domain protein
APS46_RS16155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APS46_RS16170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APS46_RS16195	COG2375	cellular response to nickel ion
APS46_RS16200	COG1695	Transcriptional regulator
APS46_RS16205	COG0840	transmembrane signaling receptor activity
APS46_RS16210	COG0840	transmembrane signaling receptor activity
APS46_RS16220	COG1902	pentaerythritol trinitrate reductase activity
APS46_RS16220	COG0446	pyridine nucleotide-disulphide oxidoreductase
APS46_RS16230	COG1451	nucleotide metabolic process
APS46_RS16235	COG2949	membrane
APS46_RS16240	COG0673	inositol 2-dehydrogenase activity
APS46_RS16255	COG0586	Pfam SNARE associated Golgi protein
APS46_RS16265	COG1422	Protein of unknown function (DUF1090)
APS46_RS16270	COG4575	ribosome binding
APS46_RS16275	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
APS46_RS16285	COG2259	Doxx family
APS46_RS16290	COG0435	Glutathione S-transferase
APS46_RS16295	COG3152	Membrane
APS46_RS16300	COG0583	DNA-binding transcription factor activity
APS46_RS16305	COG1741	Belongs to the pirin family
APS46_RS16320	COG0814	amino acid
APS46_RS16325	COG1760	l-serine dehydratase
APS46_RS16330	COG1882	Formate acetyltransferase
APS46_RS16350	COG0583	DNA-binding transcription factor activity
APS46_RS16360	COG1929	Belongs to the glycerate kinase type-1 family
APS46_RS16365	COG2084	Dehydrogenase
APS46_RS16375	COG2721	sulfolactate sulfo-lyase activity
APS46_RS16390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS16395	COG3414	Phosphotransferase system galactitol-specific IIB component
APS46_RS16400	COG3775	system Galactitol-specific IIC component
APS46_RS16405	COG1063	alcohol dehydrogenase
APS46_RS16415	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APS46_RS16420	COG3107	peptidoglycan biosynthetic process
APS46_RS16435	COG2823	Periplasmic or secreted lipoprotein
APS46_RS16440	COG0702	epimerase
APS46_RS16445	COG0693	protein deglycase activity
APS46_RS16460	COG3153	acetyltransferase
APS46_RS16465	COG3154	lipid carrier protein
APS46_RS16470	COG0826	peptidase U32
APS46_RS16475	COG0826	peptidase U32
APS46_RS16480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APS46_RS16485	COG0814	amino acid
APS46_RS16490	COG0513	Belongs to the DEAD box helicase family
APS46_RS16555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APS46_RS16565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APS46_RS16580	COG1534	Rna-binding protein
APS46_RS16595	COG2027	D-alanyl-D-alanine carboxypeptidase
APS46_RS16605	COG0697	spore germination
APS46_RS16620	COG0142	geranyltranstransferase activity
APS46_RS16625	COG3423	Transcriptional regulator
APS46_RS16635	COG5007	Belongs to the BolA IbaG family
APS46_RS16640	COG3113	response to antibiotic
APS46_RS16645	COG2854	intermembrane phospholipid transfer
APS46_RS16650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APS46_RS16655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APS46_RS16660	COG1127	ABC transporter
APS46_RS16665	COG0530	calcium, potassium:sodium antiporter activity
APS46_RS16675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APS46_RS16680	COG3117	lipopolysaccharide transmembrane transporter activity
APS46_RS16685	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APS46_RS16690	COG1137	ATPase activity
APS46_RS16715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS16720	COG0515	serine threonine protein kinase
APS46_RS16730	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
APS46_RS16735	COG5002	protein histidine kinase activity
APS46_RS16735	COG2198	Histidine kinase
APS46_RS16735	COG0784	Response regulator, receiver
APS46_RS16740	COG1242	4 iron, 4 sulfur cluster binding
APS46_RS16750	COG0070	glutamate synthase
APS46_RS16750	COG0069	glutamate synthase activity
APS46_RS16750	COG0067	glutamate synthase
APS46_RS16755	COG0493	'glutamate synthase
APS46_RS16760	COG4804	nuclease activity
APS46_RS16765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APS46_RS16770	COG0402	S-adenosylhomocysteine deaminase activity
APS46_RS16775	COG2731	YhcH YjgK YiaL family protein
APS46_RS16805	COG2969	positive regulation of protein catabolic process
APS46_RS16810	COG0625	glutathione transferase activity
APS46_RS16825	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APS46_RS16830	COG3105	Protein conserved in bacteria
APS46_RS16835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS46_RS16855	COG5016	pyruvate
APS46_RS16855	COG0511	ligase activity, forming carbon-carbon bonds
APS46_RS16865	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APS46_RS16870	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APS46_RS16875	COG0471	metal ion transport
APS46_RS16885	COG2188	Transcriptional regulator
APS46_RS16910	COG2732	(Barnase) inhibitor
APS46_RS16930	COG0583	DNA-binding transcription factor activity
APS46_RS16935	COG0312	modulator of DNA gyrase
APS46_RS16940	COG3164	Protein of unknown function
APS46_RS16955	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APS46_RS16960	COG1792	Involved in formation and maintenance of cell shape
APS46_RS16965	COG1077	Cell shape determining protein MreB Mrl
APS46_RS16975	COG2200	EAL domain
APS46_RS16975	COG2199	diguanylate cyclase activity
APS46_RS16980	COG0604	alcohol dehydrogenase
APS46_RS16995	COG0511	ligase activity, forming carbon-carbon bonds
APS46_RS17000	COG0439	Biotin carboxylase
APS46_RS17005	COG3924	membrane
APS46_RS17010	COG4145	pantothenate transmembrane transporter activity
APS46_RS17030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APS46_RS17045	COG1309	transcriptional regulator
APS46_RS17050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS46_RS17055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS46_RS17100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APS46_RS17120	COG0551	DNA topoisomerase type I activity
APS46_RS17130	COG0758	DNA mediated transformation
APS46_RS17160	COG3036	rescue of stalled ribosome
APS46_RS17165	COG0789	Transcriptional regulator
APS46_RS17205	COG0201	protein transport
APS46_RS17285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APS46_RS17310	COG0051	transcription antitermination factor activity, RNA binding
APS46_RS17365	COG2964	Protein conserved in bacteria
APS46_RS17370	COG0545	Peptidyl-prolyl cis-trans isomerase
APS46_RS17380	COG1047	Peptidyl-prolyl cis-trans
APS46_RS17385	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
APS46_RS17400	COG0488	(ABC) transporter
APS46_RS17415	COG0429	hydrolase of the alpha beta-hydrolase fold
APS46_RS17425	COG3954	Phosphoribulokinase
APS46_RS17430	COG1765	OsmC-like protein
APS46_RS17440	COG1289	transmembrane transporter activity
APS46_RS17475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APS46_RS17515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APS46_RS17520	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APS46_RS17525	COG3266	domain, Protein
APS46_RS17540	COG4796	Type ii and iii secretion system protein
APS46_RS17555	COG3166	PFAM Fimbrial assembly family protein
APS46_RS17560	COG4972	Pilus assembly protein
APS46_RS17565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APS46_RS17570	COG0494	nUDIX hydrolase
APS46_RS17580	COG1011	Hydrolase
APS46_RS17585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APS46_RS17595	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APS46_RS17620	COG2183	response to ionizing radiation
APS46_RS17625	COG1918	ferrous iron import across plasma membrane
APS46_RS17640	COG5464	transposase or invertase
APS46_RS17660	COG2610	gluconate transmembrane transporter activity
APS46_RS17665	COG1640	4-alpha-glucanotransferase
APS46_RS17670	COG0058	SHG alpha-glucan phosphorylase activity
APS46_RS17680	COG3041	Addiction module toxin RelE StbE family
APS46_RS17685	COG3077	Addiction module antitoxin, RelB DinJ family
APS46_RS17695	COG1690	Belongs to the RtcB family
APS46_RS17705	COG4650	regulator
APS46_RS17710	COG1349	DNA-binding transcription factor activity
APS46_RS17725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APS46_RS17740	COG0371	Dehydrogenase
APS46_RS17750	COG0129	dihydroxy-acid dehydratase activity
APS46_RS17755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS46_RS17760	COG1414	Transcriptional regulator
APS46_RS17765	COG0058	SHG alpha-glucan phosphorylase activity
APS46_RS17795	COG2610	gluconate transmembrane transporter activity
APS46_RS17800	COG3265	gluconokinase activity
APS46_RS17805	COG1609	Transcriptional regulator
APS46_RS17810	COG1741	Belongs to the pirin family
APS46_RS17815	COG0673	inositol 2-dehydrogenase activity
APS46_RS17820	COG1247	-acetyltransferase
APS46_RS17825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS46_RS17840	COG1735	metal-dependent hydrolase with the TIM-barrel fold
APS46_RS17845	COG0405	Gamma-glutamyltransferase
APS46_RS17855	COG0584	glycerophosphoryl diester phosphodiesterase
APS46_RS17930	COG2177	Part of the ABC transporter FtsEX involved in
APS46_RS17935	COG2884	Cell division ATP-binding protein ftsE
APS46_RS17940	COG0552	protein localization to endoplasmic reticulum
APS46_RS17945	COG0742	ribosomal rna small subunit methyltransferase
APS46_RS17950	COG3776	membrane
APS46_RS17960	COG3714	YhhN family
APS46_RS17980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APS46_RS17995	COG0628	permease
APS46_RS18000	COG2091	lysine biosynthetic process via aminoadipic acid
APS46_RS18010	COG0842	Transport permease protein
APS46_RS18015	COG1129	ABC transporter
APS46_RS18015	COG0842	Transport permease protein
APS46_RS18020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS46_RS18025	COG2081	HI0933 family
APS46_RS18030	COG0306	phosphate transporter
APS46_RS18060	COG0671	phosphoesterase, PA-phosphatase related
APS46_RS18065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APS46_RS18070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS46_RS18080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APS46_RS18085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS46_RS18090	COG2222	sugar isomerase
APS46_RS18095	COG2188	Transcriptional regulator
APS46_RS18115	COG2197	response regulator
APS46_RS18120	COG0583	DNA-binding transcription factor activity
APS46_RS18125	COG1295	ribonuclease BN
APS46_RS18130	COG0477	Major facilitator Superfamily
APS46_RS18135	COG2982	Protein involved in outer membrane biogenesis
APS46_RS18140	COG2200	EAL domain
APS46_RS18145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS46_RS18160	COG2200	EAL domain
APS46_RS18160	COG2199	diguanylate cyclase activity
APS46_RS18215	COG2873	o-acetylhomoserine
APS46_RS18220	COG0814	amino acid
APS46_RS18225	COG4608	Belongs to the ABC transporter superfamily
APS46_RS18230	COG0444	Belongs to the ABC transporter superfamily
APS46_RS18235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS46_RS18240	COG0601	transmembrane transport
APS46_RS18245	COG0747	negative chemotaxis
APS46_RS18260	COG1609	Transcriptional regulator
APS46_RS18305	COG5571	outer membrane autotransporter
APS46_RS18310	COG2818	Glycosylase
APS46_RS18315	COG0456	acetyltransferase
APS46_RS18320	COG0243	molybdopterin cofactor binding
APS46_RS18325	COG2885	chlorophyll binding
APS46_RS18340	COG2944	sequence-specific DNA binding
APS46_RS18345	COG1278	Cold shock
APS46_RS18385	COG3274	enterobacterial common antigen metabolic process
APS46_RS18390	COG4682	membrane
APS46_RS18395	COG1070	Carbohydrate kinase
APS46_RS18405	COG1609	Transcriptional regulator
APS46_RS18405	COG2207	Transcriptional regulator
APS46_RS18410	COG2992	FlgJ-related protein
APS46_RS18420	COG0366	Alpha amylase catalytic
APS46_RS18425	COG3977	Valine--pyruvate aminotransferase
APS46_RS18430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS46_RS18435	COG1414	Transcriptional regulator
APS46_RS18445	COG2731	YhcH YjgK YiaL family protein
APS46_RS18455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APS46_RS18460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APS46_RS18465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APS46_RS18470	COG1070	Carbohydrate kinase
APS46_RS18475	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APS46_RS18480	COG3623	hexulose-6-phosphate isomerase
APS46_RS18485	COG0235	Class ii aldolase
APS46_RS18500	COG1012	belongs to the aldehyde dehydrogenase family
APS46_RS18505	COG1940	carbohydrate kinase activity
APS46_RS18510	COG3276	selenocysteine insertion sequence binding
APS46_RS18520	COG0625	glutathione transferase activity
APS46_RS18525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS18525	COG2213	PTS system mannitol-specific
APS46_RS18535	COG3722	fumarate hydratase activity
APS46_RS18565	COG2186	Transcriptional regulator
APS46_RS18575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APS46_RS18580	COG1609	Transcriptional regulator
APS46_RS18590	COG2271	Major facilitator Superfamily
APS46_RS18610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APS46_RS18615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APS46_RS18625	COG4942	peptidase
APS46_RS18630	COG2861	carbohydrate metabolic process
APS46_RS18635	COG1216	Glycosyl transferase, family 2
APS46_RS18710	COG0438	transferase activity, transferring glycosyl groups
APS46_RS18715	COG0859	PFAM glycosyl transferase family 9
APS46_RS18720	COG1519	Transferase
APS46_RS18750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APS46_RS18775	COG1561	YicC-like family, N-terminal region
APS46_RS18780	COG0583	DNA-binding transcription factor activity
APS46_RS18790	COG2860	membrane
APS46_RS18810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APS46_RS18815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APS46_RS18820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APS46_RS18830	COG0786	glutamate:sodium symporter activity
APS46_RS18835	COG2233	PERMEase
APS46_RS18840	COG2982	Protein involved in outer membrane biogenesis
APS46_RS18845	COG1501	Belongs to the glycosyl hydrolase 31 family
APS46_RS18850	COG2211	Major facilitator Superfamily
APS46_RS18865	COG0419	ATPase involved in DNA repair
APS46_RS18880	COG2771	luxR family
APS46_RS18895	COG3710	Transcriptional regulator
APS46_RS18900	COG1335	isochorismatase
APS46_RS18925	COG5464	transposase or invertase
APS46_RS18940	COG3716	PTS system mannose fructose sorbose family IID component
APS46_RS18945	COG3715	PTS system
APS46_RS18950	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS18950	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APS46_RS18970	COG2723	6-phospho-beta-galactosidase activity
APS46_RS19005	COG3775	system Galactitol-specific IIC component
APS46_RS19010	COG3414	Phosphotransferase system galactitol-specific IIB component
APS46_RS19015	COG3711	transcriptional antiterminator
APS46_RS19015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS19020	COG2188	Transcriptional regulator
APS46_RS19055	COG0738	Major facilitator superfamily
APS46_RS19065	COG1349	DNA-binding transcription factor activity
APS46_RS19070	COG0440	acetolactate synthase activity
APS46_RS19075	COG0028	Belongs to the TPP enzyme family
APS46_RS19095	COG2814	Major facilitator Superfamily
APS46_RS19110	COG2610	gluconate transmembrane transporter activity
APS46_RS19120	COG0641	radical SAM
APS46_RS19130	COG2149	membrane
APS46_RS19150	COG5645	(Lipo)protein
APS46_RS19155	COG0823	Involved in the tonB-independent uptake of proteins
APS46_RS19160	COG4235	cytochrome complex assembly
APS46_RS19160	COG3088	subunit of a heme lyase
APS46_RS19170	COG1138	Cytochrome C-type biogenesis protein
APS46_RS19180	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS46_RS19185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS46_RS19190	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS46_RS19195	COG4133	protoheme IX ABC transporter activity
APS46_RS19200	COG1858	cytochrome C peroxidase
APS46_RS19215	COG3005	denitrification pathway
APS46_RS19220	COG0745	RESPONSE REGULATOR receiver
APS46_RS19225	COG1879	ABC-type sugar transport system periplasmic component
APS46_RS19230	COG2198	Histidine kinase
APS46_RS19230	COG2205	protein histidine kinase activity
APS46_RS19230	COG0784	Response regulator, receiver
APS46_RS19235	COG2271	Major facilitator Superfamily
APS46_RS19245	COG0800	Aldolase
APS46_RS19250	COG3734	2-keto-3-deoxy-galactonokinase
APS46_RS19255	COG2186	Transcriptional regulator
APS46_RS19260	COG0561	phosphatase activity
APS46_RS19265	COG2271	Major facilitator Superfamily
APS46_RS19270	COG4948	Mandelate Racemase Muconate Lactonizing
APS46_RS19335	COG2091	lysine biosynthetic process via aminoadipic acid
APS46_RS19340	COG0431	NADPH-dependent FMN reductase
APS46_RS19345	COG2252	PERMEase
APS46_RS19350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APS46_RS19355	COG0704	Plays a role in the regulation of phosphate uptake
APS46_RS19365	COG0581	inorganic phosphate transmembrane transporter activity
APS46_RS19370	COG0573	inorganic phosphate transmembrane transporter activity
APS46_RS19375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APS46_RS19380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APS46_RS19380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APS46_RS19380	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APS46_RS19385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APS46_RS19390	COG4533	DNA binding
APS46_RS19450	COG3312	ion transport
APS46_RS19465	COG0716	FMN binding
APS46_RS19470	COG1522	sequence-specific DNA binding
APS46_RS19505	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS46_RS19515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS46_RS19520	COG1609	Transcriptional regulator
APS46_RS19525	COG0477	Major facilitator Superfamily
APS46_RS19530	COG2186	Transcriptional regulator
APS46_RS19590	COG3978	acetolactate synthase activity
APS46_RS19655	COG3118	belongs to the thioredoxin family
APS46_RS19685	COG1088	dTDP-glucose 4,6-dehydratase activity
APS46_RS19690	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APS46_RS19690	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APS46_RS19695	COG0456	acetyltransferase
APS46_RS19700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APS46_RS19705	COG2244	polysaccharide biosynthetic process
APS46_RS19750	COG3071	HemY protein
APS46_RS19755	COG2959	enzyme of heme biosynthesis
APS46_RS19800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APS46_RS19805	COG1011	Hydrolase
APS46_RS19850	COG1280	lysine exporter protein (LysE YggA)
APS46_RS19860	COG2267	carboxylic ester hydrolase activity
APS46_RS19865	COG0561	phosphatase activity
APS46_RS19885	COG0641	radical SAM
APS46_RS19930	COG0805	protein transport
APS46_RS19975	COG1739	Uncharacterized protein family UPF0029
APS46_RS20020	COG1763	Mo-molybdopterin cofactor biosynthetic process
APS46_RS20030	COG3084	Protein conserved in bacteria
APS46_RS20045	COG0204	Acyl-transferase
APS46_RS20110	COG2211	Major facilitator Superfamily
APS46_RS20120	COG1501	Belongs to the glycosyl hydrolase 31 family
APS46_RS20130	COG2017	converts alpha-aldose to the beta-anomer
APS46_RS20140	COG3684	Belongs to the aldolase LacD family
APS46_RS20150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS46_RS20155	COG1349	DNA-binding transcription factor activity
APS46_RS20160	COG1011	Hydrolase
APS46_RS20175	COG0456	acetyltransferase
APS46_RS20180	COG5499	transcription regulator containing HTH domain
APS46_RS20185	COG4680	protein conserved in bacteria
APS46_RS20195	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APS46_RS20210	COG2864	formate dehydrogenase
APS46_RS20215	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS20220	COG0243	molybdopterin cofactor binding
APS46_RS20220	COG3383	formate dehydrogenase (NAD+) activity
APS46_RS20225	COG0243	molybdopterin cofactor binding
APS46_RS20225	COG3383	formate dehydrogenase (NAD+) activity
APS46_RS20250	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APS46_RS20265	COG1454	alcohol dehydrogenase
APS46_RS20315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APS46_RS20325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APS46_RS20330	COG2258	MOSC domain
APS46_RS20345	COG2205	protein histidine kinase activity
APS46_RS20350	COG0745	RESPONSE REGULATOR receiver
APS46_RS20355	COG3678	ATP-independent chaperone mediated protein folding
APS46_RS20380	COG2211	Major facilitator Superfamily
APS46_RS20395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APS46_RS20410	COG1070	Carbohydrate kinase
APS46_RS20465	COG3152	Membrane
APS46_RS20475	COG1494	fructose-1,6-bisphosphatase
APS46_RS20485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APS46_RS20500	COG1575	Belongs to the MenA family. Type 1 subfamily
APS46_RS20515	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APS46_RS20520	COG1609	Transcriptional regulator
APS46_RS20525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APS46_RS20550	COG0626	cystathionine gamma-synthase activity
APS46_RS20555	COG0460	homoserine dehydrogenase
APS46_RS20555	COG0527	aspartate kinase activity
APS46_RS20560	COG0668	transmembrane transport
APS46_RS20575	COG0737	Belongs to the 5'-nucleotidase family
APS46_RS20590	COG3738	Protein conserved in bacteria
APS46_RS20595	COG0371	Dehydrogenase
APS46_RS20605	COG2207	Transcriptional regulator
APS46_RS20640	COG0583	DNA-binding transcription factor activity
APS46_RS20750	COG0250	Participates in transcription elongation, termination and antitermination
APS46_RS20810	COG2104	thiamine diphosphate biosynthetic process
APS46_RS20815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APS46_RS20880	COG0151	Belongs to the GarS family
APS46_RS20920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APS46_RS20965	COG3122	Protein conserved in bacteria
APS46_RS21010	COG5301	cellulose 1,4-beta-cellobiosidase activity
APS46_RS21040	COG2246	polysaccharide biosynthetic process
APS46_RS21115	COG0527	aspartate kinase activity
APS46_RS21140	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APS46_RS21195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APS46_RS21205	COG0534	Mate efflux family protein
APS46_RS21220	COG0735	belongs to the Fur family
APS46_RS21270	COG2315	Protein conserved in bacteria
APS46_RS21335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APS46_RS21355	COG2252	PERMEase
APS46_RS21360	COG0025	NhaP-type Na H and K H
APS46_RS21365	COG0583	DNA-binding transcription factor activity
APS46_RS21370	COG1380	Effector of murein hydrolase LrgA
APS46_RS21375	COG1346	cytolysis
APS46_RS21385	COG3162	membrane
APS46_RS21390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APS46_RS21405	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APS46_RS21410	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS21415	COG3301	Polysulphide reductase, NrfD
APS46_RS21420	COG1138	Cytochrome C-type biogenesis protein
APS46_RS21425	COG3088	subunit of a heme lyase
APS46_RS21430	COG4235	cytochrome complex assembly
APS46_RS21435	COG1301	dicarboxylic acid transport
APS46_RS21440	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APS46_RS21445	COG3383	formate dehydrogenase (NAD+) activity
APS46_RS21450	COG3383	formate dehydrogenase (NAD+) activity
APS46_RS21465	COG2764	glyoxalase bleomycin resistance protein dioxygenase
APS46_RS21470	COG2824	Alkylphosphonate utilization operon protein PhnA
APS46_RS21495	COG0531	amino acid
APS46_RS21500	COG2207	Transcriptional regulator
APS46_RS21510	COG1982	Orn Lys Arg decarboxylase major
APS46_RS21515	COG2169	Transcriptional regulator
APS46_RS21530	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APS46_RS21530	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APS46_RS21535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APS46_RS21545	COG4565	transcriptional regulatory protein
APS46_RS21550	COG3290	protein histidine kinase activity
APS46_RS21555	COG0243	molybdopterin cofactor binding
APS46_RS21560	COG0437	4 iron, 4 sulfur cluster binding
APS46_RS21565	COG3302	dmso reductase anchor subunit
APS46_RS21570	COG3381	protein complex oligomerization
APS46_RS21585	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
APS46_RS21590	COG2197	response regulator
APS46_RS21610	COG2801	Transposase and inactivated derivatives
APS46_RS21625	COG3328	transposase activity
APS46_RS21630	COG3328	transposase activity
APS46_RS21645	COG1309	transcriptional regulator
APS46_RS21660	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APS46_RS21665	COG1027	Aspartate ammonia-lyase
APS46_RS21675	COG3030	protein affecting phage T7 exclusion by the F plasmid
APS46_RS21680	COG0531	amino acid
APS46_RS21720	COG5510	response to toxic substance
APS46_RS21750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APS46_RS21755	COG1053	succinate dehydrogenase
APS46_RS21775	COG3264	Mechanosensitive ion channel
APS46_RS21775	COG1511	domain protein
APS46_RS21795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS46_RS21820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APS46_RS21820	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APS46_RS21825	COG0802	atpase or kinase
APS46_RS21850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APS46_RS21855	COG0330	HflC and HflK could
APS46_RS21860	COG0330	HflC and HflK could
APS46_RS21865	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
APS46_RS21880	COG0557	exoribonuclease II activity
APS46_RS21890	COG3789	protein conserved in bacteria
APS46_RS21895	COG1842	Phage shock protein A
APS46_RS21910	COG3766	membrane
APS46_RS21915	COG5463	Belongs to the UPF0441 family
APS46_RS21920	COG0754	glutathionylspermidine amidase activity
APS46_RS21925	COG1960	acyl-CoA dehydrogenase activity
APS46_RS21935	COG3650	response to hydrogen peroxide
APS46_RS21940	COG1073	alpha beta
APS46_RS21955	COG3037	sugar-specific permease SgaT UlaA
APS46_RS22005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APS46_RS22020	COG3061	Opacity-associated protein A
APS46_RS22025	COG0545	Peptidyl-prolyl cis-trans isomerase
APS46_RS22030	COG1113	amino acid transport
APS46_RS22040	COG0697	spore germination
APS46_RS22045	COG0702	epimerase
APS46_RS22050	COG1733	regulation of RNA biosynthetic process
APS46_RS22065	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APS46_RS22075	COG1253	flavin adenine dinucleotide binding
APS46_RS22095	COG2105	PFAM AIG2 family protein
APS46_RS22100	COG2271	Major facilitator Superfamily
APS46_RS22105	COG3964	amidohydrolase
APS46_RS22120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APS46_RS22130	COG0312	modulator of DNA gyrase
APS46_RS22165	COG3964	amidohydrolase
APS46_RS22180	COG3711	transcriptional antiterminator
APS46_RS22180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS46_RS22185	COG3077	Addiction module antitoxin, RelB DinJ family
APS46_RS22190	COG2026	Addiction module toxin, RelE StbE family
APS46_RS22210	COG0366	Alpha amylase catalytic
APS46_RS22215	COG1263	PTS System
APS46_RS22215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APS46_RS22255	COG1438	arginine binding
APS46_RS22260	COG1288	antiporter activity
APS46_RS22280	COG2731	YhcH YjgK YiaL family protein
APS46_RS22325	COG2927	DNA polymerase III (CHI subunit)
APS46_RS22340	COG0795	lipopolysaccharide-transporting ATPase activity
APS46_RS22345	COG0795	lipopolysaccharide-transporting ATPase activity
APS46_RS22350	COG1609	Transcriptional regulator
APS46_RS22355	COG2610	gluconate transmembrane transporter activity
APS46_RS22360	COG1028	Short-chain dehydrogenase reductase Sdr
APS46_RS22365	COG1063	alcohol dehydrogenase
APS46_RS22370	COG3265	gluconokinase activity
APS46_RS22375	COG1064	alcohol dehydrogenase
APS46_RS22385	COG0582	viral genome integration into host DNA
APS46_RS22400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APS46_RS22410	COG1111	helicase
APS46_RS22410	COG1205	dead DEAH box helicase
APS46_RS22415	COG0210	DNA helicase
APS46_RS22440	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
APS46_RS22470	COG0412	Dienelactone hydrolase
APS46_RS22475	COG2186	Transcriptional regulator
APS46_RS22500	COG0583	DNA-binding transcription factor activity
APS46_RS22505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APS46_RS22510	COG0700	Nucleoside recognition
APS46_RS22515	COG3366	ferrous iron transmembrane transporter activity
APS46_RS22525	COG0477	Major facilitator Superfamily
APS46_RS22530	COG2733	membrane
APS46_RS22540	COG5464	transposase or invertase
APS46_RS22540	COG5464	transposase or invertase
APS46_RS22545	COG1012	belongs to the aldehyde dehydrogenase family
APS46_RS22580	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
APS46_RS22585	COG1715	Restriction endonuclease
APS46_RS22600	COG0523	cobalamin synthesis protein
APS46_RS22605	COG2879	small protein
APS46_RS22610	COG1966	Carbon starvation protein
APS46_RS22615	COG0840	transmembrane signaling receptor activity
APS46_RS22630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APS46_RS22635	COG3715	PTS system
APS46_RS22640	COG3716	PTS system mannose fructose sorbose family IID component
APS46_RS22645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APS46_RS22665	COG1484	DNA-dependent DNA replication
APS46_RS22680	COG2966	Psort location CytoplasmicMembrane, score
APS46_RS22685	COG2197	response regulator
APS46_RS22690	COG2197	response regulator
APS46_RS22695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APS46_RS22700	COG4114	ferric iron reductase
APS46_RS22705	COG3706	GGDEF domain
APS46_RS22735	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
APS46_RS22745	COG1011	Hydrolase
APS46_RS22755	COG2823	Periplasmic or secreted lipoprotein
APS46_RS22765	COG4667	esterase of the alpha-beta hydrolase superfamily
APS46_RS22770	COG0084	hydrolase, TatD family'
APS46_RS22775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APS46_RS22780	COG1328	CTP reductase activity
APS46_RS22810	COG3188	usher protein
APS46_RS22815	COG3121	Chaperone
APS46_RS22820	COG3539	Fimbrial protein
APS46_RS22835	COG3726	membrane protein affecting hemolysin expression
APS46_RS22840	COG0560	Phosphoserine phosphatase
APS46_RS22855	COG0488	(ABC) transporter
APS46_RS22880	COG2207	Transcriptional regulator
APS46_RS22880	COG3708	Transcriptional regulator
APS46_RS22885	COG3045	CreA protein
APS46_RS22890	COG0745	RESPONSE REGULATOR receiver
APS46_RS22895	COG2205	protein histidine kinase activity
APS46_RS22900	COG4452	Inner membrane protein CreD
APS46_RS22920	COG3121	Chaperone
APS46_RS22940	COG0745	RESPONSE REGULATOR receiver
APS46_RS22950	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APS46_RS22960	COG0527	aspartate kinase activity
APS46_RS22960	COG0460	homoserine dehydrogenase
APS46_RS23110	COG3121	Chaperone
APS46_RS23165	COG0527	aspartate kinase activity
APS46_RS23165	COG0460	homoserine dehydrogenase
APS46_RS23180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APS46_RS23395	COG3119	arylsulfatase activity