locus-tag class description HEC75_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEC75_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC75_RS00030 ENOG4105CXK mandelate racemase muconate lactonizing HEC75_RS00035 ENOG4105DJB Major Facilitator Superfamily HEC75_RS00040 ENOG410667J hydrolase HEC75_RS00045 ENOG4105EMF GntR family transcriptional regulator HEC75_RS00050 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HEC75_RS00055 ENOG4108RTU Aldolase HEC75_RS00065 ENOG4105DJB Major Facilitator Superfamily HEC75_RS00070 ENOG4105BZU Histidine kinase HEC75_RS00075 ENOG4108SV3 Tmao reductase system periplasmic protein tort HEC75_RS00080 ENOG4106WF9 DNA-binding transcriptional regulator TorR HEC75_RS00085 ENOG4105CUW cytochrome C-TYPE protein HEC75_RS00090 ENOG4108EM1 reductase HEC75_RS00100 ENOG4105CA0 peroxidase HEC75_RS00110 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HEC75_RS00115 ENOG41060IM Heme exporter protein HEC75_RS00120 ENOG4105X3C heme exporter protein HEC75_RS00130 ENOG4105DA4 cytochrome c-type biogenesis protein HEC75_RS00135 ENOG4107QX9 Thiol disulfide interChange protein HEC75_RS00140 ENOG4105KWW Biogenesis protein HEC75_RS00145 ENOG4105D99 atp gtp-binding protein HEC75_RS00150 ENOG4105R2A (LipO)protein HEC75_RS00170 ENOG4105VG5 Membrane HEC75_RS00175 ENOG4105JP4 Inner membrane protein yidG HEC75_RS00180 ENOG4105J13 transcriptional regulator HEC75_RS00195 ENOG4105W8I Transcriptional regulator HEC75_RS00205 ENOG4105E5M Multidrug resistance protein D HEC75_RS00230 ENOG4105C7K acetolactate synthase HEC75_RS00235 ENOG4105M71 acetolactate synthase 1 regulatory subunit HEC75_RS00240 ENOG4107FB0 transcriptional regulator DeoR family HEC75_RS00250 ENOG4105EDR glucose galactose transporter HEC75_RS00260 ENOG4108KX4 response regulator HEC75_RS00265 ENOG4105BZU Histidine kinase HEC75_RS00270 ENOG4105CXY transporter HEC75_RS00280 ENOG4108SAJ Protein of unknown function (DUF1198) HEC75_RS00295 ENOG41090UW PTS System HEC75_RS00300 ENOG4105DT3 PTS system, galactitol-specific IIc component HEC75_RS00310 ENOG4105D2N Aldolase HEC75_RS00335 ENOG4105CS2 ec 3.2.1.21 HEC75_RS00355 ENOG4105DAS pts system HEC75_RS00360 ENOG4105ETZ PTS System HEC75_RS00365 ENOG4105F3R pts system mannose fructose sorbose family iid HEC75_RS00380 ENOG4105DNE Transposase HEC75_RS00385 ENOG4108UZ3 Transporter HEC75_RS00395 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEC75_RS00410 ENOG4105CHJ isochorismatase hydrolase HEC75_RS00420 ENOG4108TC1 Transcriptional regulator HEC75_RS00425 ENOG4105FV3 HEC75_RS00435 ENOG4105ISV protein with bipartite regulator domain HEC75_RS00455 ENOG4107WZZ SMC domain protein HEC75_RS00475 ENOG4105CT4 transporter HEC75_RS00480 ENOG4105CJQ hydrolase, family 31 HEC75_RS00485 ENOG4105JV1 AsmA family HEC75_RS00490 ENOG4105C2W permease HEC75_RS00495 ENOG4105D6U Sodium Glutamate Symporter HEC75_RS00500 ENOG4105CB5 ATP-dependent DNA helicase recG HEC75_RS00505 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HEC75_RS00510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEC75_RS00530 ENOG4105EN6 Membrane HEC75_RS00545 ENOG4105DSJ YicC domain protein HEC75_RS00550 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HEC75_RS00570 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HEC75_RS00600 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HEC75_RS00605 ENOG4105DKP glycosyl transferase, family 9 HEC75_RS00610 ENOG4107RJ7 Glycosyl transferase (Group 1 HEC75_RS00615 ENOG4107543 (lipo)polysaccharide HEC75_RS00620 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide HEC75_RS00625 ENOG4107XU6 Glycosyl transferase (Group 1 HEC75_RS00630 ENOG4106AH0 Glycosyl Transferase HEC75_RS00635 ENOG4105X1N Glycosyl transferase family 8 HEC75_RS00640 ENOG4108PDR lipopolysaccharide core biosynthesis protein HEC75_RS00645 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HEC75_RS00650 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HEC75_RS00655 ENOG4108FRV O-antigen ligase HEC75_RS00660 ENOG4105D16 lipopolysaccharide heptosyltransferase i HEC75_RS00665 ENOG4105XA0 heptosyltransferase ii HEC75_RS00675 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HEC75_RS00685 ENOG4105K64 Glycosyl transferase, family 2 HEC75_RS00690 ENOG4105PXI polysaccharide deacetylase HEC75_RS00695 ENOG41063SB peptidase HEC75_RS00705 ENOG4107YZP Rhodanese domain protein HEC75_RS00710 ENOG4105VW4 glutaredoxin 3 HEC75_RS00715 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HEC75_RS00720 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEC75_RS00725 ENOG4105D7W serine acetyltransferase HEC75_RS00730 ENOG4105DJB Major Facilitator Superfamily HEC75_RS00735 ENOG4105DIA mandelate racemase muconate lactonizing HEC75_RS00740 ENOG4105ETE Transcriptional regulator (LacI family HEC75_RS00745 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HEC75_RS00755 ENOG41073TP transcriptional regulator HEC75_RS00760 ENOG4105DAA L-lactate HEC75_RS00765 ENOG4105EUR Domain-Containing protein HEC75_RS00770 ENOG4108WY4 inner membrane lipoprotein HEC75_RS00775 ENOG4108YYI Protein of unknown function (DUF2810) HEC75_RS00785 ENOG4105E61 Mannitol repressor protein HEC75_RS00790 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HEC75_RS00795 ENOG4105CTS PTS system mannitol-specific HEC75_RS00800 ENOG4108U78 Glutathione S-transferase HEC75_RS00810 ENOG4105EM7 Selenocysteine-specific translation elongation factor HEC75_RS00815 ENOG41066F8 ROK family HEC75_RS00820 ENOG4105C26 Dehydrogenase HEC75_RS00835 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HEC75_RS00840 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HEC75_RS00845 ENOG4105H6Q decarboxylase HEC75_RS00850 ENOG4105CMG Carbohydrate kinase HEC75_RS00855 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HEC75_RS00860 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HEC75_RS00865 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HEC75_RS00870 ENOG4108M5W HEC75_RS00875 ENOG4108R66 Conserved Protein HEC75_RS00880 ENOG4105DG4 malate L-lactate dehydrogenase HEC75_RS00885 ENOG4105J4Q Transcriptional regulator HEC75_RS00890 ENOG4108XIB electron transport protein ysaA HEC75_RS00895 ENOG4105JKW Valine--pyruvate aminotransferase HEC75_RS00900 ENOG4107T9C Alpha amylase catalytic region HEC75_RS00905 ENOG4108UR8 BAX protein HEC75_RS00910 ENOG4105T16 Transcriptional regulator (AraC family) HEC75_RS00915 ENOG4105C93 Xylose Isomerase HEC75_RS00920 ENOG4105CMG Carbohydrate kinase HEC75_RS00925 ENOG410688U Inner membrane protein yiaB HEC75_RS00930 ENOG4105MEV Acyl-transferase HEC75_RS00950 ENOG4108RS6 transposase HEC75_RS00965 ENOG4105MVF Transcriptional regulator HEC75_RS00970 ENOG4106JH6 (LipO)protein HEC75_RS00980 ENOG4108ZG0 Ompa motb domain protein HEC75_RS00985 ENOG4107QY8 reductase HEC75_RS00990 ENOG4105HNP -acetyltransferase HEC75_RS00995 ENOG4108R3E Dna-3-methyladenine glycosylase i HEC75_RS01000 ENOG4105EAX Putative lipase HEC75_RS01005 ENOG4105DIJ Phosphoethanolamine transferase HEC75_RS01020 ENOG4108RS6 transposase HEC75_RS01030 ENOG4105CQ4 Transcriptional regulator HEC75_RS01045 ENOG4105DEF Extracellular solute-binding protein, family 5 HEC75_RS01050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC75_RS01055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEC75_RS01060 ENOG4105C3U ABC transporter HEC75_RS01065 ENOG4108JQ7 (ABC) transporter HEC75_RS01070 ENOG4105C44 Serine transporter HEC75_RS01085 ENOG4105D1V cellulose synthase operon protein YhjU HEC75_RS01090 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HEC75_RS01100 ENOG410661M cytoplasmic protein HEC75_RS01105 ENOG4105UTS cellulose synthase operon protein YhjQ HEC75_RS01110 ENOG4107QZ7 Cellulose synthase catalytic subunit HEC75_RS01115 ENOG4107EEX Cellulose synthase regulator protein HEC75_RS01120 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HEC75_RS01125 ENOG4105EJG cellulose synthase HEC75_RS01130 ENOG4105BZU Histidine kinase HEC75_RS01140 ENOG4105CS0 peptidase HEC75_RS01145 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HEC75_RS01150 ENOG4105CMB EAL domain-containing protein HEC75_RS01155 ENOG41066T0 asmA family HEC75_RS01160 ENOG4105CSH Transporter HEC75_RS01165 ENOG4107H3J ribonuclease HEC75_RS01170 ENOG4105CBN LysR family transcriptional regulator HEC75_RS01175 ENOG4106S2D Transcriptional regulator HEC75_RS01195 ENOG4105FDP GntR family transcriptional regulator HEC75_RS01200 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HEC75_RS01205 ENOG4108KPW sugar kinase HEC75_RS01210 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HEC75_RS01220 ENOG4105DC8 reductase HEC75_RS01225 ENOG4105D6S protein involved in catabolism of external DNA HEC75_RS01230 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEC75_RS01235 ENOG4105DGW oligopeptidase A HEC75_RS01245 ENOG4105DUX Transporter HEC75_RS01250 ENOG4108M6U Universal stress protein A HEC75_RS01260 ENOG4105CJ3 phosphate transporter HEC75_RS01265 ENOG4105CBX hi0933 family HEC75_RS01270 ENOG4105D0S secretion protein (HlyD HEC75_RS01275 ENOG4105CJ1 ABC, transporter HEC75_RS01280 ENOG4105CMI transporter HEC75_RS01290 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HEC75_RS01295 ENOG4105DSF transport protein HEC75_RS01305 ENOG4108W1V Lipoprotein HEC75_RS01310 ENOG4105EX9 Membrane HEC75_RS01320 ENOG4105C8Q Methyl-accepting chemotaxis HEC75_RS01330 ENOG4107FS9 Membrane HEC75_RS01340 ENOG4105MG3 Membrane HEC75_RS01345 ENOG4106H78 methyltransferase HEC75_RS01350 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HEC75_RS01355 ENOG4105CAK Cell division ATP-binding protein ftsE HEC75_RS01360 ENOG4105CRP Part of the ABC transporter FtsEX involved in HEC75_RS01370 ENOG4105CP9 extracellular ligand-binding receptor HEC75_RS01380 ENOG4105U59 -acetyltransferase HEC75_RS01385 ENOG4105CP9 extracellular ligand-binding receptor HEC75_RS01390 ENOG4105C32 Amino acid ABC transporter (Permease) HEC75_RS01395 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HEC75_RS01400 ENOG4105C0Z ABC transporter HEC75_RS01405 ENOG4108IV0 ABC, transporter HEC75_RS01415 ENOG4105BZ7 extracellular solute-binding protein family 1 HEC75_RS01430 ENOG4108IJ9 (ABC) transporter HEC75_RS01435 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HEC75_RS01440 ENOG4105WC8 Conserved Protein HEC75_RS01445 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HEC75_RS01450 ENOG41080QX K07048 phosphotriesterase-related protein HEC75_RS01465 ENOG4108RVA ribokinase HEC75_RS01470 ENOG4105WCN acetyltransferase HEC75_RS01475 ENOG4105D9R oxidoreductase HEC75_RS01480 ENOG4105C2I pirin domain protein HEC75_RS01485 ENOG4105DIQ Transcriptional regulator HEC75_RS01490 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEC75_RS01495 ENOG4105C6Z Gluconate HEC75_RS01505 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HEC75_RS01510 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HEC75_RS01530 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEC75_RS01535 ENOG4107HP6 Transcriptional regulator HEC75_RS01540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEC75_RS01545 ENOG4105C01 Dihydroxy-acid dehydratase HEC75_RS01555 ENOG4105DCT glycerol dehydrogenase HEC75_RS01570 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HEC75_RS01585 ENOG4105E98 transcriptional regulator DeoR family HEC75_RS01595 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEC75_RS01600 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HEC75_RS01605 ENOG4105C6Z Gluconate HEC75_RS01615 ENOG4105MJ2 Competence protein HEC75_RS01625 ENOG4105DNE Transposase HEC75_RS01640 ENOG4105XFK Ferrous iron transport protein A HEC75_RS01645 ENOG4105BZM domain protein HEC75_RS01650 ENOG4108RRZ Transcription elongation factor GreB HEC75_RS01660 ENOG4105E0F Histidine kinase HEC75_RS01670 ENOG4108MAJ Membrane HEC75_RS01680 ENOG4105VEJ Heat shock protein HEC75_RS01685 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HEC75_RS01695 ENOG4107RK2 ADP-ribose diphosphatase NudE HEC75_RS01700 ENOG4108JQC penicillin-binding protein 1A HEC75_RS01705 ENOG4108U1Q Pilus assembly protein HEC75_RS01710 ENOG41065NF Fimbrial assembly family protein HEC75_RS01715 ENOG4105XPX DNA utilization protein HofO HEC75_RS01720 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HEC75_RS01725 ENOG4105E4G Type IV pilus HEC75_RS01740 ENOG4105EGB membrane protein DamX HEC75_RS01745 ENOG4105DFE Dna adenine methylase HEC75_RS01750 ENOG4105DJV ribulose-phosphate 3-epimerase HEC75_RS01760 ENOG4105C31 Tryptophanyl-tRNA synthetase HEC75_RS01765 ENOG4105VYH HEC75_RS01770 ENOG4107EF2 surface-exposed virulence protein HEC75_RS01775 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HEC75_RS01780 ENOG4107V9H nitrite transporter HEC75_RS01785 ENOG4105WZK nitrite reductase NADPH small subunit HEC75_RS01790 ENOG4107QZF nitrite reductase NADPH large subunit HEC75_RS01800 ENOG4106DTQ Protein TsgA homolog HEC75_RS01805 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HEC75_RS01810 ENOG4106195 uncharacterized protein yhfG HEC75_RS01815 ENOG4105MZU cell filamentation protein HEC75_RS01820 ENOG4105DDQ anthranilate synthase HEC75_RS01825 ENOG4105C8Y Acetylornithine aminotransferase HEC75_RS01830 ENOG410613R integral membrane protein, YccS YhfK family HEC75_RS01835 ENOG4107RYR Transcriptional regulator, Crp Fnr family HEC75_RS01840 ENOG4108UKZ OsmC family HEC75_RS01845 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HEC75_RS01855 ENOG4105DNZ Alpha Beta Hydrolase HEC75_RS01860 ENOG4105N0V mono-oxygenase ydhR HEC75_RS01865 ENOG4108K70 Transcriptional regulator HEC75_RS01870 ENOG4105C5H ABC transporter HEC75_RS01885 ENOG4105VKU nucleicacid-binding protein HEC75_RS01890 ENOG4108YZY peptidylprolyl cis-trans isomerase HEC75_RS01895 ENOG4105VRX Protein slyX homolog HEC75_RS01900 ENOG4108V1T peptidylprolyl cis-trans isomerase HEC75_RS01905 ENOG4105WWK YheO domain protein HEC75_RS01930 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HEC75_RS01940 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEC75_RS01945 ENOG4105W53 bacterioferritin-associated ferredoxin HEC75_RS01950 ENOG4108UQY Iron-storage protein HEC75_RS01955 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HEC75_RS01985 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HEC75_RS02005 ENOG41083MP 50s ribosomal protein l29 HEC75_RS02010 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HEC75_RS02020 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HEC75_RS02045 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HEC75_RS02055 ENOG4105VPB 50S ribosomal protein L30 HEC75_RS02065 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HEC75_RS02070 ENOG41067V7 50S ribosomal protein L36 HEC75_RS02085 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HEC75_RS02100 ENOG4105VTS DnaJ-like, subfamily C HEC75_RS02105 ENOG4105W1Y Transcriptional regulator HEC75_RS02110 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HEC75_RS02115 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HEC75_RS02120 ENOG4105C1A potassium transporter peripheral membrane HEC75_RS02140 ENOG4105C79 DNA protecting protein DprA HEC75_RS02150 ENOG4108WI1 Dna topoisomerase HEC75_RS02165 ENOG4105SG3 Protein of unknown function (DUF1488) HEC75_RS02170 ENOG4108Z0R Transferase HEC75_RS02210 ENOG4105XCM membrane LIPOPROTEIN HEC75_RS02215 ENOG4105BZS acriflavin resistance protein HEC75_RS02220 ENOG4105C1P efflux transporter, rnd family, mfp subunit HEC75_RS02225 ENOG4108XG4 DNA-binding transcriptional regulator HEC75_RS02230 ENOG4105BZU Histidine kinase HEC75_RS02235 ENOG41061ME transport protein HEC75_RS02240 ENOG4105CEC DNA methylase N-4 N-6 HEC75_RS02250 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HEC75_RS02265 ENOG4108IA2 Sodium pantothenate symporter HEC75_RS02270 ENOG4105RG0 Membrane HEC75_RS02275 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HEC75_RS02280 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HEC75_RS02295 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HEC75_RS02300 ENOG41062P1 Diguanylate cyclase phosphodiesterase HEC75_RS02310 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HEC75_RS02315 ENOG4105VQ7 Rod shape-determining protein MreD HEC75_RS02325 ENOG4105C03 ribonuclease HEC75_RS02330 ENOG4105QD6 exported protein HEC75_RS02335 ENOG4105D1U peptidase U62 modulator of DNA gyrase HEC75_RS02340 ENOG4105CR8 Transcriptional regulator HEC75_RS02345 ENOG4105ZQC membrane protein AaeX HEC75_RS02360 ENOG4108RS6 transposase HEC75_RS02365 ENOG4105UNR (Barnase) inhibitor HEC75_RS02370 ENOG4105RID UPF0379 protein yhcN HEC75_RS02375 ENOG4105RID UPF0379 protein yhcN HEC75_RS02400 ENOG4105C8P )-transporter HEC75_RS02405 ENOG4106DSS Tartrate dehydratase subunit alpha HEC75_RS02410 ENOG4107GFK fumarate HEC75_RS02420 ENOG4107QSA Oxaloacetate decarboxylase HEC75_RS02425 ENOG4105D9Q decarboxylase (Beta subunit) HEC75_RS02440 ENOG4105C0H protease HEC75_RS02445 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HEC75_RS02450 ENOG4105D6Z AFG1 family ATPase HEC75_RS02470 ENOG4107MKT Stringent starvation protein a HEC75_RS02475 ENOG4105KB2 stringent starvation protein b HEC75_RS02505 ENOG4108R66 Conserved Protein HEC75_RS02510 ENOG4105DZC cytosine deaminase HEC75_RS02515 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HEC75_RS02520 ENOG4105DFS Conserved Protein HEC75_RS02525 ENOG4105BZ8 glutamate synthase HEC75_RS02530 ENOG4105CBC glutamate synthase HEC75_RS02535 ENOG4105N5T Radical SAM Protein HEC75_RS02540 ENOG4105BZU Histidine kinase HEC75_RS02545 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HEC75_RS02555 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HEC75_RS02560 ENOG41080Z8 PHOSPHOCARRIER protein HEC75_RS02570 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HEC75_RS02575 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HEC75_RS02580 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC75_RS02585 ENOG4108IUZ ABC transporter HEC75_RS02590 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HEC75_RS02595 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HEC75_RS02600 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HEC75_RS02605 ENOG4105C2X Arabinose 5-phosphate isomerase HEC75_RS02610 ENOG4105FEU K -dependent Na -Ca exchanger HEC75_RS02615 ENOG4105DHJ ABC, transporter HEC75_RS02620 ENOG4105CY3 ABC transporter, permease HEC75_RS02625 ENOG4107PE3 Mammalian cell entry related domain protein HEC75_RS02630 ENOG4105E3I toluene tolerance HEC75_RS02635 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HEC75_RS02640 ENOG4105VFK BolA family HEC75_RS02650 ENOG4105HVQ Regulatory factor of maltose metabolism HEC75_RS02655 ENOG4105EAH synthase HEC75_RS02665 ENOG4105K46 50S ribosomal protein l27 HEC75_RS02670 ENOG4105QYV Membrane HEC75_RS02680 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HEC75_RS02685 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEC75_RS02690 ENOG4105HBR Rna-binding protein HEC75_RS02700 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEC75_RS02705 ENOG4105EEI dihydropteroate synthase HEC75_RS02715 ENOG4105NTZ Preprotein translocase subunit SecG HEC75_RS02740 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HEC75_RS02745 ENOG4105CHV Transcription elongation factor NusA HEC75_RS02785 ENOG4105C1J atp-dependent rna helicase HEC75_RS02790 ENOG4105CIC tryptophan-specific transport protein HEC75_RS02800 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HEC75_RS02805 ENOG4105DEN Luciferase family HEC75_RS02825 ENOG4108YYD acetyltransferase HEC75_RS02840 ENOG4107R7Y intracellular protease Pfpi family HEC75_RS02845 ENOG4105K4T epimerase HEC75_RS02850 ENOG4105W4M Transport-associated protein HEC75_RS02865 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HEC75_RS02870 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HEC75_RS02880 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HEC75_RS02885 ENOG4105DT3 PTS system, galactitol-specific IIc component HEC75_RS02890 ENOG41090UW PTS System HEC75_RS02895 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HEC75_RS02910 ENOG4105CTX dehydratase HEC75_RS02920 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEC75_RS02925 ENOG4105BZW Glycerate kinase HEC75_RS02935 ENOG410811B TRANSCRIPTIONal HEC75_RS02940 ENOG4105C7B Threonine dehydratase HEC75_RS02950 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEC75_RS02955 ENOG4105C6N Formate acetyltransferase HEC75_RS02960 ENOG4105EJQ L-serine dehydratase HEC75_RS02965 ENOG4105C44 Serine transporter HEC75_RS02975 ENOG4106D80 Uncharacterized protein YhaL HEC75_RS02980 ENOG4108CNN domain protein HEC75_RS02985 ENOG4105CWB LysR family transcriptional Regulator HEC75_RS02990 ENOG4105KAF membrAne HEC75_RS02995 ENOG4105CHF Glutathione S-transferase HEC75_RS03000 ENOG4108VBZ doxx family HEC75_RS03005 ENOG4105YJD HEC75_RS03010 ENOG41090KG Inner membrane protein YqjE HEC75_RS03015 ENOG4105NE1 Conserved Protein HEC75_RS03020 ENOG4105WAY exported protein HEC75_RS03030 ENOG4106W5V Membrane HEC75_RS03040 ENOG4105DU1 integral membrane protein, terc HEC75_RS03045 ENOG4105EE0 oxidoreductase HEC75_RS03050 ENOG4108UB4 uncharacterized protein ygjQ HEC75_RS03055 ENOG4108VKG metal-dependent hydrolase HEC75_RS03065 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEC75_RS03075 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HEC75_RS03085 ENOG4105C8Q Methyl-accepting chemotaxis HEC75_RS03090 ENOG4105NTW Transcriptional regulator HEC75_RS03095 ENOG4105Q26 Siderophore-interacting protein HEC75_RS03100 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC75_RS03115 ENOG4105MEH HEC75_RS03145 ENOG4108IRC dna polymerase iii HEC75_RS03155 ENOG4105DFE Dna adenine methylase HEC75_RS03160 ENOG4105VZ1 Replication Protein HEC75_RS03175 ENOG4105ED4 portal protein HEC75_RS03270 ENOG4108X9F tail fiber protein HEC75_RS03305 ENOG4108VCA G U mismatch-specific DNA glycosylase HEC75_RS03310 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC75_RS03315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HEC75_RS03345 ENOG4107ZVW dihydroneopterin aldolase HEC75_RS03360 ENOG4106MWK domain protein HEC75_RS03365 ENOG4105I7R Adenylate cyclase HEC75_RS03385 ENOG4107S78 Band 7 protein HEC75_RS03390 ENOG4105PV3 Inner membrane protein yqiJ HEC75_RS03400 ENOG4105W0Z cytoplasmic protein HEC75_RS03410 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) HEC75_RS03420 ENOG4108MR7 Arylsulfotransferase HEC75_RS03430 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HEC75_RS03435 ENOG4106032 Glutathionylspermidine synthase HEC75_RS03440 ENOG4105F1G UPF0441 protein HEC75_RS03450 ENOG41087AY ADP-Ribose pyrophosphatase HEC75_RS03455 ENOG4108SX3 cytoplasmic protein HEC75_RS03460 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HEC75_RS03465 ENOG4105IPS esterase HEC75_RS03470 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC75_RS03475 ENOG4105VRH Antibiotic biosynthesis monooxygenase HEC75_RS03480 ENOG4105NF4 modulator of drug activity HEC75_RS03485 ENOG4105DHQ Histidine kinase HEC75_RS03490 ENOG4105XJC Two component transcriptional regulator (Winged helix family HEC75_RS03495 ENOG4105H4F exported protein HEC75_RS03500 ENOG4105F4I Transcriptional regulator HEC75_RS03505 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC75_RS03510 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HEC75_RS03515 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HEC75_RS03540 ENOG4105CCT upf0313 protein HEC75_RS03550 ENOG4107QPK )-transporter HEC75_RS03555 ENOG4105CV8 reductase HEC75_RS03560 ENOG4108I6A alcohol dehydrogenase HEC75_RS03565 ENOG4105CF7 AraC family transcriptional regulator HEC75_RS03570 ENOG4108K81 inner membrane protein YghB HEC75_RS03575 ENOG4105C28 cystathionine HEC75_RS03580 ENOG4105CWK Biopolymer transport protein, ExbB HEC75_RS03585 ENOG4108ZZF transport protein (ExbD) HEC75_RS03590 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEC75_RS03615 ENOG4105C8Q Methyl-accepting chemotaxis HEC75_RS03620 ENOG410900S Protein of unknown function (DUF2623) HEC75_RS03625 ENOG4105E3S small subunit HEC75_RS03630 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC75_RS03635 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HEC75_RS03640 ENOG4105DPX Hydrogenase, large subunit HEC75_RS03645 ENOG4108USZ hydrogenase HEC75_RS03650 ENOG4108WGS hydrogenase 2-specific chaperone HEC75_RS03655 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HEC75_RS03660 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HEC75_RS03665 ENOG4105S10 periplasmic binding protein HEC75_RS03670 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HEC75_RS03675 ENOG4105CYM Glutathione S-transferase HEC75_RS03680 ENOG4106032 Glutathionylspermidine synthase HEC75_RS03695 ENOG4105DEI Mannitol dehydrogenase HEC75_RS03705 ENOG4105DPW Major facilitator superfamily MFS_1 HEC75_RS03730 ENOG4105C26 Dehydrogenase HEC75_RS03735 ENOG4105CJP fad dependent oxidoreductase HEC75_RS03745 ENOG4105CUB amino acid HEC75_RS03755 ENOG4108UAJ Transcriptional regulator HEC75_RS03760 ENOG4105E3J oxidoreductase HEC75_RS03765 ENOG41066GK UPF0379 protein ykgI HEC75_RS03785 ENOG4108UQV Membrane HEC75_RS03795 ENOG4108BUD transposase HEC75_RS03810 ENOG4108BUD transposase HEC75_RS03825 ENOG4108BUD transposase HEC75_RS03865 ENOG4108BUD transposase HEC75_RS03885 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HEC75_RS03920 ENOG4108BUD transposase HEC75_RS03940 ENOG4108BUD transposase HEC75_RS04025 ENOG4105I1F Resistance protein HEC75_RS04035 ENOG4108BUD transposase HEC75_RS04055 ENOG4108BUD transposase HEC75_RS04070 ENOG4108BUD transposase HEC75_RS04105 ENOG4108BUD transposase HEC75_RS04130 ENOG4108KTG Membrane protein, drug metabolite transporter HEC75_RS04230 ENOG4108YX2 DNA-binding protein HEC75_RS04285 ENOG4105CAF HipA N-terminal domain protein HEC75_RS04365 ENOG4105DAX Pfam:DUF2983 HEC75_RS04395 ENOG4108M24 von Willebrand factor, type A HEC75_RS04400 ENOG4108M24 von Willebrand factor, type A HEC75_RS04545 ENOG4105C4R Atp-dependent dna helicase HEC75_RS04685 ENOG4106JVB Replication Protein HEC75_RS04710 ENOG4105DFE Dna adenine methylase HEC75_RS04750 ENOG4106JVB Replication Protein HEC75_RS04770 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEC75_RS04940 ENOG41074AV Hok/gef family HEC75_RS04945 ENOG4108BUD transposase HEC75_RS04955 ENOG4108R0M Aminoglycoside HEC75_RS04980 ENOG4108BUD transposase HEC75_RS04990 ENOG4105EAA nucleoside HEC75_RS05000 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HEC75_RS05005 ENOG4105CEN a g-specific adenine glycosylase HEC75_RS05015 ENOG41090ED Protein with unknown function (DUF469) HEC75_RS05020 ENOG4105K33 Periplasmic Protein HEC75_RS05025 ENOG4105HDK L-asparaginase HEC75_RS05030 ENOG4106MH3 alpha helix chain HEC75_RS05035 ENOG4105CSA Coproporphyrinogen iii oxidase HEC75_RS05040 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HEC75_RS05050 ENOG4108VIA integral membrane protein HEC75_RS05055 ENOG4105DFA alanine racemase domain protein HEC75_RS05060 ENOG4105CZX twitching motility protein HEC75_RS05080 ENOG4105D7Z glutathione synthase HEC75_RS05085 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HEC75_RS05090 ENOG4105RWS endonuclease I HEC75_RS05125 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HEC75_RS05135 ENOG4108K0D peptidase, M48 HEC75_RS05140 ENOG4105CV1 Transketolase (EC 2.2.1.1) HEC75_RS05145 ENOG4108JJB ABC transporter HEC75_RS05150 ENOG4108JJB ABC transporter HEC75_RS05175 ENOG4105BZA Phosphoglycerate kinase HEC75_RS05180 ENOG4105D2N Aldolase HEC75_RS05185 ENOG4105D64 Mechanosensitive ion channel HEC75_RS05195 ENOG4105MPN Membrane HEC75_RS05215 ENOG4108JQ1 Dehydrogenase HEC75_RS05220 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HEC75_RS05240 ENOG4107RAQ aminopeptidase HEC75_RS05245 ENOG4105D0A hydroxylase HEC75_RS05250 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HEC75_RS05275 ENOG4105CS2 ec 3.2.1.21 HEC75_RS05285 ENOG4108UT2 hemolysin iii HEC75_RS05305 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HEC75_RS05310 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HEC75_RS05315 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC75_RS05320 ENOG4105T95 Thiol disulfide interChange protein HEC75_RS05325 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HEC75_RS05345 ENOG4108K5P (LipO)protein HEC75_RS05365 ENOG4105VGJ Virulence-associated protein HEC75_RS05370 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HEC75_RS05375 ENOG4108T1M outer membrane protein x HEC75_RS05395 ENOG4106P2F Pfam:Pili_assembly_C HEC75_RS05425 ENOG4108MHD transport protein HEC75_RS05435 ENOG4105C5Q Transcriptional regulator HEC75_RS05440 ENOG4105CHU acetyl-coa acetyltransferase HEC75_RS05450 ENOG4105CHR reductase HEC75_RS05455 ENOG4107QNK )-transporter HEC75_RS05465 ENOG4105RQF LysR family Transcriptional regulator HEC75_RS05475 ENOG4105DDV Transcriptional regulator (LacI family HEC75_RS05495 ENOG4105CPC Aldo Keto reductase HEC75_RS05500 ENOG4105SUV lipoprotein YgdR HEC75_RS05505 ENOG4105EE5 Membrane protein terC HEC75_RS05520 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HEC75_RS05535 ENOG4105IPU prepilin peptidase dependent protein A HEC75_RS05540 ENOG4105JCS prepilin peptidase dependent protein HEC75_RS05545 ENOG4105SEN Protein of unknown function (DUF2509) HEC75_RS05550 ENOG4105RVB Prepilin peptidase dependent protein c HEC75_RS05555 ENOG4105DSY exodeoxyribonuclease V, gamma HEC75_RS05560 ENOG4107QXK peptidase HEC75_RS05565 ENOG4107QKA exodeoxyribonuclease V beta HEC75_RS05570 ENOG4107QYX exodeoxyribonuclease v alpha HEC75_RS05575 ENOG4108EKC n-acetylglutamate synthase HEC75_RS05580 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HEC75_RS05595 ENOG4105CA3 membrane-bound lytic murein transglycosylase HEC75_RS05600 ENOG4105CUZ uba thif-type nad fad binding protein HEC75_RS05605 ENOG4105FR1 rard protein HEC75_RS05610 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HEC75_RS05615 ENOG4105C9B Cysteine desulfurase HEC75_RS05620 ENOG4105M5B (LipO)protein HEC75_RS05625 ENOG4105ETT transcriptional Regulator, LysR family HEC75_RS05630 ENOG4105M08 Membrane HEC75_RS05640 ENOG4107EDW L-fucose operon activator HEC75_RS05650 ENOG4105CMG Carbohydrate kinase HEC75_RS05660 ENOG4105EDR glucose galactose transporter HEC75_RS05665 ENOG4107W7X Aldolase HEC75_RS05670 ENOG4105C0A alcohol dehydrogenase HEC75_RS05680 ENOG4105EJQ L-serine dehydratase HEC75_RS05685 ENOG4105C44 Serine transporter HEC75_RS05690 ENOG4105EWT decarboxylase family HEC75_RS05715 ENOG4105DR9 pseudouridine synthase HEC75_RS05720 ENOG4105QDK Flavodoxin HEC75_RS05730 ENOG4105DJB Major Facilitator Superfamily HEC75_RS05735 ENOG4105EQX glucarate dehydratase HEC75_RS05740 ENOG4105EQX glucarate dehydratase HEC75_RS05745 ENOG4105BZW Glycerate kinase HEC75_RS05750 ENOG4105BZU Histidine kinase HEC75_RS05755 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HEC75_RS05760 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEC75_RS05765 ENOG4105X54 addiction module antidote protein HEC75_RS05795 ENOG4105NEV Fimbrial HEC75_RS05800 ENOG4108FZ9 Chaperone HEC75_RS05805 ENOG4106PG1 outer membrane usher protein HEC75_RS05815 ENOG4105DXN mazG family HEC75_RS05825 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HEC75_RS05830 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HEC75_RS05835 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEC75_RS05840 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HEC75_RS05855 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HEC75_RS05865 ENOG4105DTT CRISPR-associated helicase, cas3 HEC75_RS05880 ENOG41060M0 Crispr-associated protein, cse4 family HEC75_RS05885 ENOG4108VWQ crispr-associated protein HEC75_RS05895 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HEC75_RS05900 ENOG4105PWE CRISPR-associated protein cas2 HEC75_RS05905 ENOG4108MXK alkaline phosphatase isozyme conversion HEC75_RS05925 ENOG4105N0Z inner membrane protein ygbE HEC75_RS05960 ENOG4108K5P (LipO)protein HEC75_RS05970 ENOG4105KZM cytoplasmic protein HEC75_RS05975 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEC75_RS05980 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEC75_RS05990 ENOG4105MVE transcriptional regulator HEC75_RS06000 ENOG4105G63 Type III effector Hrp-dependent HEC75_RS06010 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HEC75_RS06015 ENOG4105EXW epimerase dehydratase HEC75_RS06020 ENOG4105C6Z Gluconate HEC75_RS06025 ENOG4105JQN Transcriptional regulator HEC75_RS06030 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC75_RS06065 ENOG4105MEW serine threonine protein phosphatase HEC75_RS06110 ENOG41090HZ type iii secretion HEC75_RS06120 ENOG4108N8R Invasion protein HEC75_RS06125 ENOG4108HR8 type iii secretion HEC75_RS06130 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone HEC75_RS06135 ENOG4108JIR Flagellum-specific ATP synthase HEC75_RS06140 ENOG41077MC Secretory protein (Associated with virulence) HEC75_RS06145 ENOG41078G4 surface presentation of HEC75_RS06150 ENOG4105T85 surface presentation of antigens protein HEC75_RS06155 ENOG41075IY surface presentation of antigens protein SpaP HEC75_RS06160 ENOG4105U07 type iii secretion HEC75_RS06165 ENOG4108TN6 type iii secretion HEC75_RS06170 ENOG4108M6W surface presentation of antigens protein SpaS HEC75_RS06180 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE HEC75_RS06190 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HEC75_RS06195 ENOG4105MH6 Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates SipC activity HEC75_RS06200 ENOG41079WB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEC75_RS06215 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear HEC75_RS06225 ENOG4108YAB Invasion protein HEC75_RS06235 ENOG4108RC9 Type III secretion system protein HEC75_RS06240 ENOG4105Y7Q type iii secretion HEC75_RS06245 ENOG4106BTR HEC75_RS06250 ENOG4108RBT type iii secretion HEC75_RS06280 ENOG4105CC5 ABC transporter HEC75_RS06285 ENOG4105CC5 ABC transporter HEC75_RS06290 ENOG4105DIK (ABC) transporter HEC75_RS06300 ENOG4105VXR cytoplasmic protein HEC75_RS06310 ENOG4105C45 hydrogenase expression formation protein (HypE) HEC75_RS06315 ENOG4105CQS hydrogenase expression formation protein HypD HEC75_RS06320 ENOG41083WG hydrogenase assembly chaperone HEC75_RS06325 ENOG4107RSS Hydrogenase accessory protein HypB HEC75_RS06330 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HEC75_RS06335 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HEC75_RS06340 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HEC75_RS06345 ENOG4107R30 NADH dehydrogenase HEC75_RS06350 ENOG4107TDF Formate hydrogenlyase subunit 4 HEC75_RS06355 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC75_RS06360 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HEC75_RS06365 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HEC75_RS06370 ENOG4105I6X formate hydrogenlyase maturation HEC75_RS06375 ENOG4108MG9 hydrogenase 3 maturation protease HEC75_RS06385 ENOG4108RC0 Electron transport protein HEC75_RS06390 ENOG4105C8H hydrogenase maturation protein Hypf HEC75_RS06410 ENOG4105C2X Arabinose 5-phosphate isomerase HEC75_RS06415 ENOG410804X Transcriptional regulator HEC75_RS06420 ENOG4105J92 DNA-binding transcriptional activator GutM HEC75_RS06425 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HEC75_RS06430 ENOG4105VI0 Pts system, glucitol sorbitol-specific HEC75_RS06435 ENOG4105DZY Pts system, glucitol sorbitol-specific HEC75_RS06440 ENOG410787A Pts system, glucitol sorbitol-specific HEC75_RS06445 ENOG4105CVE Lytic murein transglycosylase HEC75_RS06450 ENOG4107TH8 cina domain protein HEC75_RS06465 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HEC75_RS06470 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HEC75_RS06500 ENOG4107VXZ Hydrolase HEC75_RS06505 ENOG4105W39 Membrane HEC75_RS06525 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC75_RS06530 ENOG4105CW7 secretion protein, HlyD family HEC75_RS06535 ENOG4105NTK Transcriptional repressor Mpra HEC75_RS06545 ENOG4105GIJ Glycine betaine HEC75_RS06550 ENOG4108HQS Glycine betaine HEC75_RS06555 ENOG4108IJ7 Glycine betaine HEC75_RS06560 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC75_RS06565 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC75_RS06575 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HEC75_RS06580 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEC75_RS06590 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HEC75_RS06595 ENOG4108WMJ Protein of unknown function (DUF2002) HEC75_RS06600 ENOG4108RNS Exports L-alanine (By similarity) HEC75_RS06605 ENOG4108X73 DNA- binding protein HEC75_RS06615 ENOG4108V62 Rhodanese domain protein HEC75_RS06620 ENOG41080HT Transcriptional regulator, arsr family HEC75_RS06625 ENOG4105VPI YqaE family transport protein HEC75_RS06630 ENOG4109066 lysm domain bon superfamily protein HEC75_RS06635 ENOG4108PVQ transcriptional regulator HEC75_RS06640 ENOG4105C85 amino acid HEC75_RS06645 ENOG4108JPW Aminotransferase HEC75_RS06650 ENOG4105C26 Dehydrogenase HEC75_RS06655 ENOG4105D5U fad dependent oxidoreductase HEC75_RS06685 ENOG4105DHQ Histidine kinase HEC75_RS06700 ENOG4108MJ5 VirK protein HEC75_RS06715 ENOG4107RNH Outer membrane receptor FepA HEC75_RS06720 ENOG4105NIV Esterase HEC75_RS06740 ENOG4108C33 Resolvase HEC75_RS06745 ENOG4105I03 Flagellin HEC75_RS06785 ENOG4105DFP Integrase HEC75_RS06820 ENOG4108Z1B Cyclase dehydrase HEC75_RS06830 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC75_RS06835 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HEC75_RS06855 ENOG4108JU6 CBS domain protein HEC75_RS06860 ENOG4106KVJ cytochrome C assembly protein HEC75_RS06865 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HEC75_RS06885 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HEC75_RS06890 ENOG4108KHX Diguanylate cyclase HEC75_RS06895 ENOG4108WS1 HEC75_RS06900 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC75_RS06905 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HEC75_RS06915 ENOG4105CQC Prephenate dehydratase HEC75_RS06925 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC75_RS06965 ENOG4105ED4 portal protein HEC75_RS07055 ENOG4108X9F tail fiber protein HEC75_RS07085 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HEC75_RS07090 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HEC75_RS07095 ENOG4105C34 Pseudouridine synthase HEC75_RS07100 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HEC75_RS07105 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC75_RS07135 ENOG4105CSH Transporter HEC75_RS07140 ENOG4105T42 (LipO)protein HEC75_RS07145 ENOG4105JIM Phosphatidylserine synthase HEC75_RS07150 ENOG4105CD5 CoA-binding domain protein HEC75_RS07155 ENOG4106IUH DTW domain containing protein HEC75_RS07160 ENOG4105K63 Thioredoxin HEC75_RS07165 ENOG4105EIB trna rrna methyltransferase HEC75_RS07175 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HEC75_RS07185 ENOG41090KR LysR family transcriptional Regulator HEC75_RS07190 ENOG4105C1J atp-dependent rna helicase HEC75_RS07200 ENOG4108IYU L-aspartate oxidase HEC75_RS07225 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HEC75_RS07235 ENOG4105C3F Signal peptidase i HEC75_RS07265 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HEC75_RS07270 ENOG4105DND Transcriptional regulator HEC75_RS07280 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEC75_RS07285 ENOG4106G6Q Transcriptional regulator HEC75_RS07300 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HEC75_RS07305 ENOG4108Z6B deaminase HEC75_RS07310 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HEC75_RS07320 ENOG4108ETH Formylglycinamide ribotide synthetase HEC75_RS07325 ENOG4107WP9 Histidine kinase HEC75_RS07330 ENOG4108SKK alpha helix protein HEC75_RS07335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC75_RS07345 ENOG4105DUX Transporter HEC75_RS07350 ENOG4105CXN decarboxylase HEC75_RS07355 ENOG4105D5Q Arginine ornithine antiporter HEC75_RS07360 ENOG4108M3R transcriptional activator CadC HEC75_RS07370 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEC75_RS07380 ENOG4105D8G Major Facilitator superfamily HEC75_RS07385 ENOG4108MN2 Stationary phase inducible protein CsiE HEC75_RS07395 ENOG4105D7X high-affinity nickel-transporter HEC75_RS07400 ENOG410810Y Sulfite reductase HEC75_RS07405 ENOG4107SHJ sulfite reductase subunit b HEC75_RS07415 ENOG4107XM9 (LipO)protein HEC75_RS07420 ENOG4105ECY inositol monophosphatase HEC75_RS07425 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HEC75_RS07440 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HEC75_RS07445 ENOG4108Z4V iron-sulfur cluster assembly HEC75_RS07460 ENOG4108ZIT Ferredoxin, 2FE-2S HEC75_RS07465 ENOG4105WVQ Fe-S assembly protein IscX HEC75_RS07475 ENOG4105YYA enhanced serine sensitivity protein SseB HEC75_RS07485 ENOG4105KHC sulfurtransferase HEC75_RS07490 ENOG4105DN3 alpha-2-macroglobulin domain protein HEC75_RS07495 ENOG4108JQB penicillin-binding protein 1C HEC75_RS07500 ENOG4107QY8 reductase HEC75_RS07505 ENOG4105QAX Iron-sulfur HEC75_RS07545 ENOG4105N21 Membrane HEC75_RS07550 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC75_RS07560 ENOG4105VPD cellular component movement HEC75_RS07600 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEC75_RS07620 ENOG41066DY Membrane HEC75_RS07625 ENOG4108ZMA Outer membrane lipoprotein HEC75_RS07630 ENOG41062G3 Protein of unknown function (DUF2633) HEC75_RS07640 ENOG4105BZU Histidine kinase HEC75_RS07645 ENOG4105C9X ppx gppa phosphatase HEC75_RS07650 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HEC75_RS07655 ENOG4108V3E phosphoribosylglycinamide formyltransferase HEC75_RS07665 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HEC75_RS07670 ENOG4105C2W permease HEC75_RS07680 ENOG4105K89 arsenate reductase HEC75_RS07685 ENOG4105ERG peptidase m48, ste24p HEC75_RS07690 ENOG4105C02 permease HEC75_RS07695 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HEC75_RS07700 ENOG4107QQ0 gntp family HEC75_RS07705 ENOG4105BZW Glycerate kinase HEC75_RS07710 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HEC75_RS07715 ENOG4105RH4 Glycine cleavage system transcriptional repressor HEC75_RS07720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEC75_RS07725 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC75_RS07735 ENOG4105CGZ zinc metallopeptidase HEC75_RS07740 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HEC75_RS07750 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HEC75_RS07755 ENOG4105KUZ arsenate reductase HEC75_RS07765 ENOG4105BZS acriflavin resistance protein HEC75_RS07770 ENOG4105BZU Histidine kinase HEC75_RS07775 ENOG4105BZ8 glutamate synthase HEC75_RS07785 ENOG4107VIJ nudix hydrolase HEC75_RS07790 ENOG4108PVD exported protein HEC75_RS07800 ENOG4105CV1 Transketolase (EC 2.2.1.1) HEC75_RS07805 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEC75_RS07810 ENOG4105C6K Malic enzyme HEC75_RS07815 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HEC75_RS07820 ENOG4106S4J ethanolamine utilization protein EutP HEC75_RS07825 ENOG4105NDK ethanolamine utilization protein HEC75_RS07830 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HEC75_RS07835 ENOG4108IJ2 phosphate acetyltransferase HEC75_RS07840 ENOG4105KNY Microcompartments protein HEC75_RS07845 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HEC75_RS07850 ENOG4108EKI Dehydrogenase HEC75_RS07855 ENOG4107YMV ethanolamine utilization protein HEC75_RS07860 ENOG4105C0A alcohol dehydrogenase HEC75_RS07865 ENOG4105ENY Ethanolamine utilization protein eutH HEC75_RS07870 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HEC75_RS07875 ENOG4105CPD ethanolamine ammonia-lyase HEC75_RS07885 ENOG4106D67 ethanolamine utilization protein HEC75_RS07890 ENOG4108X49 Ethanolamine utilization protein EutK HEC75_RS07895 ENOG4108K3Z AraC family transcriptional regulator HEC75_RS07905 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HEC75_RS07910 ENOG4108R6G acetyltransferase HEC75_RS07915 ENOG4105QZU Inner membrane protein YfeZ HEC75_RS07920 ENOG4105E7K (LipO)protein HEC75_RS07925 ENOG4105EZR dyp-type peroxidase family protein HEC75_RS07930 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HEC75_RS07935 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HEC75_RS07940 ENOG4108I5D sulfate abc transporter HEC75_RS07945 ENOG4105ECW sulfate abc transporter HEC75_RS07950 ENOG4108IJ6 ABC transporter HEC75_RS07955 ENOG4105C6T cysteine synthase HEC75_RS07960 ENOG4105M0Y HEC75_RS07965 ENOG41089BK Glutamine amido-transferase HEC75_RS07970 ENOG4105CSW GntR family transcriptional regulator HEC75_RS07975 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HEC75_RS07985 ENOG4105C5Y PTS System HEC75_RS07990 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HEC75_RS08000 ENOG4105C6T cysteine synthase HEC75_RS08020 ENOG4105VRT cytoplasmic protein HEC75_RS08025 ENOG4105DHU Bile acid HEC75_RS08030 ENOG4108M0I Transcriptional regulator HEC75_RS08035 ENOG4108NFH Sugar hydrolase HEC75_RS08040 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HEC75_RS08045 ENOG4105EAA nucleoside HEC75_RS08055 ENOG4105CN8 Transcriptional regulator HEC75_RS08085 ENOG4105GXM Putative transcription regulator (DUF1323) HEC75_RS08090 ENOG4105HZG regulatoR HEC75_RS08105 ENOG4108KMM Diguanylate cyclase HEC75_RS08110 ENOG4105D9N nucleoside HEC75_RS08120 ENOG4109076 Conserved Protein HEC75_RS08125 ENOG4105CPC Aldo Keto reductase HEC75_RS08130 ENOG4107RA9 decarboxylase HEC75_RS08150 ENOG4105CHM Aminotransferase HEC75_RS08160 ENOG4105D1S lipid A biosynthesis HEC75_RS08165 ENOG4105W9M Membrane HEC75_RS08170 ENOG4105CXY transporter HEC75_RS08175 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HEC75_RS08185 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HEC75_RS08190 ENOG4108NC2 Outer membrane protease HEC75_RS08210 ENOG4105EXC Acyl-transferase HEC75_RS08215 ENOG4105CKK Glycosyl transferase, family 2 HEC75_RS08220 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HEC75_RS08225 ENOG4108BUD transposase HEC75_RS08240 ENOG4105S64 Formate nitrite transporter HEC75_RS08245 ENOG410903C (LipO)protein HEC75_RS08250 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HEC75_RS08255 ENOG4105KZW UPF0381 protein HEC75_RS08270 ENOG4108BY2 phosphohistidine phosphatase HEC75_RS08280 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HEC75_RS08295 ENOG4105EJ9 Membrane HEC75_RS08300 ENOG4108BPE -transporting atpase HEC75_RS08305 ENOG4105MH2 YfcL protein HEC75_RS08310 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HEC75_RS08315 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEC75_RS08345 ENOG4106WZ1 flagella biosynthesis regulator HEC75_RS08355 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HEC75_RS08365 ENOG4105DQR SNARE associated Golgi HEC75_RS08375 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HEC75_RS08380 ENOG4108S3P Sporulation domain protein HEC75_RS08385 ENOG4105E96 Colicin v production protein HEC75_RS08390 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HEC75_RS08395 ENOG4108JUB Transcriptional regulator HEC75_RS08410 ENOG4106M28 alanine racemase domain protein HEC75_RS08420 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEC75_RS08425 ENOG4105E89 ABC transporter HEC75_RS08430 ENOG4105E89 ABC transporter HEC75_RS08435 ENOG4105DSP amino acid AbC transporter HEC75_RS08440 ENOG4106YG3 ABC transporter HEC75_RS08445 ENOG4108JEH abc transporter atp-binding protein HEC75_RS08450 ENOG4105ECP epimerase HEC75_RS08455 ENOG4105CYM Glutathione S-transferase HEC75_RS08460 ENOG4108SHQ Glutathione S-transferase HEC75_RS08465 ENOG4108RE9 Phosphodiesterase HEC75_RS08470 ENOG4105PTV Nudix Hydrolase HEC75_RS08475 ENOG4105K2J Transcriptional regulator HEC75_RS08480 ENOG4106ETB IIa component HEC75_RS08490 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HEC75_RS08495 ENOG4108HHA Transketolase HEC75_RS08500 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HEC75_RS08505 ENOG4105CSX c4-dicarboxylate anaerobic carrier HEC75_RS08510 ENOG4105C6K Malic enzyme HEC75_RS08515 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEC75_RS08530 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HEC75_RS08535 ENOG4107QWE )-transporter HEC75_RS08545 ENOG4105CHM Aminotransferase HEC75_RS08550 ENOG4107NQ8 LysR family Transcriptional regulator HEC75_RS08560 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEC75_RS08565 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC75_RS08575 ENOG4105GKE subunit e HEC75_RS08580 ENOG4107QIZ NADH dehydrogenase HEC75_RS08585 ENOG4108IEH NADH dehydrogenase subunit g HEC75_RS08600 ENOG4107UFS subunit j HEC75_RS08610 ENOG4105D65 subunit l HEC75_RS08615 ENOG4105C8S subunit m HEC75_RS08635 ENOG4107YB6 acetyltransferase, (GNAT) family HEC75_RS08640 ENOG4105TNS Conserved Protein HEC75_RS08645 ENOG4105E4F Isochorismate synthase HEC75_RS08660 ENOG4108IPT Naphthoate synthase HEC75_RS08670 ENOG4105CEY Amp-dependent synthetase and ligase HEC75_RS08675 ENOG4106GZG polymyxin resistance protein B HEC75_RS08725 ENOG4108UII YfaZ family HEC75_RS08730 ENOG4108EWA cinA-like protein HEC75_RS08740 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HEC75_RS08750 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HEC75_RS08755 ENOG4105CXY transporter HEC75_RS08760 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HEC75_RS08765 ENOG4105GZI Transcriptional regulator HEC75_RS08770 ENOG4105CZM Major Facilitator HEC75_RS08775 ENOG4105XPH Ferredoxin HEC75_RS08780 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC75_RS08785 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC75_RS08805 ENOG4105CXK mandelate racemase muconate lactonizing HEC75_RS08810 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC75_RS08815 ENOG4105BZU Histidine kinase HEC75_RS08820 ENOG41068CG regulatoR HEC75_RS08825 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HEC75_RS08830 ENOG4105FCK Membrane HEC75_RS08835 ENOG4105CJ2 (LipO)protein HEC75_RS08840 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEC75_RS08845 ENOG4105CF1 Alkylated DNA repair protein HEC75_RS08850 ENOG4105IBP Cyclic peptide transporter HEC75_RS08860 ENOG4108ZNS ferredoxin-type protein NapF HEC75_RS08865 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HEC75_RS08875 ENOG4108BGM Quinol dehydrogenase periplasmic component HEC75_RS08880 ENOG4105GXZ Ferredoxin-type protein NapH HEC75_RS08885 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HEC75_RS08890 ENOG4105CUW cytochrome C-TYPE protein HEC75_RS08900 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HEC75_RS08905 ENOG41060IM Heme exporter protein HEC75_RS08910 ENOG4105X3C heme exporter protein HEC75_RS08920 ENOG4105DA4 cytochrome c-type biogenesis protein HEC75_RS08925 ENOG4107QX9 Thiol disulfide interChange protein HEC75_RS08930 ENOG4105KWW Biogenesis protein HEC75_RS08935 ENOG4105WH1 Two component transcriptional regulator luxr family HEC75_RS08975 ENOG4105E68 Sulfatase HEC75_RS09000 ENOG4105CFI type iii restriction protein res subunit HEC75_RS09005 ENOG4105I08 Pseudouridine synthase HEC75_RS09010 ENOG4105C2C drug resistance transporter, Bcr CflA HEC75_RS09015 ENOG4105HG6 HEC75_RS09020 ENOG4108JQ5 ABC transporter HEC75_RS09025 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HEC75_RS09030 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HEC75_RS09035 ENOG4105E43 Extracellular solute-binding protein, family 5 HEC75_RS09040 ENOG4105CXC rtn protein HEC75_RS09045 ENOG4107TT5 NLP P60 protein HEC75_RS09050 ENOG41076MN Phosphoesterase, PA-phosphatase related HEC75_RS09055 ENOG4105CKI cobalamin synthesis protein HEC75_RS09060 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HEC75_RS09065 ENOG4105KRS Proteinase inhibitor HEC75_RS09080 ENOG4105S8Q sugar efflux transporter HEC75_RS09085 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HEC75_RS09090 ENOG4105DE4 1-phosphofructokinase HEC75_RS09095 ENOG4105DM4 PTS System HEC75_RS09100 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HEC75_RS09105 ENOG4105HMI Membrane HEC75_RS09110 ENOG4105DUM transcriptional regulator, lysR family HEC75_RS09115 ENOG4108IQI permease HEC75_RS09120 ENOG4105D05 Receptor HEC75_RS09125 ENOG4105CXY transporter HEC75_RS09130 ENOG4105EAC phosphoserine phosphatase HEC75_RS09135 ENOG4105EJQ L-serine dehydratase HEC75_RS09150 ENOG4105EUJ GTP cyclohydrolase i HEC75_RS09155 ENOG4105DHF Membrane HEC75_RS09160 ENOG41060NJ transcriptional regulator HEC75_RS09165 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HEC75_RS09170 ENOG4105C2J ABC transporter HEC75_RS09175 ENOG4107SDZ Galactoside transport system permease protein mglC HEC75_RS09180 ENOG4107SJI Dehydrogenase HEC75_RS09185 ENOG4105BZ8 glutamate synthase HEC75_RS09190 ENOG4105Y9N Membrane HEC75_RS09195 ENOG4107GZ4 SanA protein HEC75_RS09205 ENOG41067MG lrgb family HEC75_RS09235 ENOG4108RXX maleylacetoacetate isomerase HEC75_RS09240 ENOG4105MSY salicylate hydroxylase HEC75_RS09245 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HEC75_RS09255 ENOG4105ETP RND efflux system, outer membrane lipoprotein HEC75_RS09260 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEC75_RS09265 ENOG4105KHU inner membrane protein YohD HEC75_RS09270 ENOG41069YE inner membrane protein yohC HEC75_RS09275 ENOG41061WM D-Alanyl-D-Alanine HEC75_RS09280 ENOG4105CXG d-lactate dehydrogenase HEC75_RS09285 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEC75_RS09290 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HEC75_RS09295 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HEC75_RS09300 ENOG4108IJ8 ABC transporter HEC75_RS09305 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HEC75_RS09320 ENOG4108HRK Histidine kinase HEC75_RS09325 ENOG4108NEV two component transcriptional regulator, LytTR family HEC75_RS09330 ENOG4108W15 Protein of unknown function (DUF1456) HEC75_RS09340 ENOG4108YCW (LipO)protein HEC75_RS09350 ENOG4105D1F ATP-binding protein HEC75_RS09365 ENOG4108MQF Chaperone HEC75_RS09370 ENOG4105CW0 outer membrane usher protein HEC75_RS09380 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HEC75_RS09390 ENOG4105DWF phosphomethylpyrimidine kinase HEC75_RS09395 ENOG4105FDP GntR family transcriptional regulator HEC75_RS09400 ENOG4108TFM Kinase, PfkB family HEC75_RS09405 ENOG4108KD5 ADP-ribosylation crystallin J1 HEC75_RS09410 ENOG4105EAA nucleoside HEC75_RS09415 ENOG4105EIE fructose-bisphosphate aldolase HEC75_RS09430 ENOG41090V3 Tir chaperone protein (CesT) family HEC75_RS09440 ENOG4105CFP Peptidase U32 HEC75_RS09480 ENOG4105CNA YD repeat protein HEC75_RS09485 ENOG4105CNA YD repeat protein HEC75_RS09495 ENOG4105NUP lyase containing HEAT-repeat HEC75_RS09545 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC75_RS09550 ENOG4105EB3 Histidine kinase HEC75_RS09800 ENOG4105D03 DNA-3-methyladenine glycosylase II HEC75_RS09805 ENOG4105BZU Histidine kinase HEC75_RS09820 ENOG4108GAE asmA family HEC75_RS09825 ENOG4105EE5 Membrane protein terC HEC75_RS09830 ENOG4105DAY polysaccharide export protein HEC75_RS09835 ENOG4105KJF protein tyrosine phosphatase HEC75_RS09840 ENOG4105D75 Capsular exopolysaccharide family HEC75_RS09845 ENOG41090RK glycosyl transferase HEC75_RS09850 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HEC75_RS09855 ENOG4107RXY Glycosyl transferase HEC75_RS09860 ENOG4108NYJ Colanic acid HEC75_RS09865 ENOG4105ECJ Glycosyl Transferase HEC75_RS09870 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HEC75_RS09875 ENOG4105C0K Gdp-mannose 4,6-dehydratase HEC75_RS09880 ENOG4105C30 Nad-dependent epimerase dehydratase HEC75_RS09885 ENOG4105FGF GDP-mannose mannosyl hydrolase HEC75_RS09890 ENOG4106CD9 glycosyl transferase group 1 HEC75_RS09895 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HEC75_RS09900 ENOG4107QKV phosphomannomutase HEC75_RS09905 ENOG4105D3Q Sugar transferase HEC75_RS09910 ENOG4105PSV Polysaccharide Biosynthesis Protein HEC75_RS09915 ENOG4105C74 pyruvyl transferase HEC75_RS09920 ENOG4107T8Q Glycosyl transferase (Group 1 HEC75_RS09925 ENOG4105G1A colanic acid biosynthesis protein HEC75_RS09930 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEC75_RS09935 ENOG4105C1B dTDP-glucose 4-6-dehydratase HEC75_RS09940 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HEC75_RS09945 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HEC75_RS09950 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEC75_RS09955 ENOG4107QK7 reductase HEC75_RS09960 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HEC75_RS09965 ENOG4105FAW cDP-glucose 4,6-dehydratase HEC75_RS09970 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HEC75_RS09975 ENOG4108SMP Nad-dependent epimerase dehydratase HEC75_RS09980 ENOG4105FB1 Polysaccharide Biosynthesis Protein HEC75_RS09985 ENOG4107YYJ Glycosyl transferase, family 2 HEC75_RS09990 ENOG4108TJN glycosyl transferase group 1 HEC75_RS09995 ENOG4108KBE Glycosyl transferase, family 2 HEC75_RS10000 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HEC75_RS10005 ENOG4106ECQ phosphomannomutase HEC75_RS10010 ENOG4105D3Q Sugar transferase HEC75_RS10015 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HEC75_RS10020 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEC75_RS10025 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HEC75_RS10030 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HEC75_RS10045 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HEC75_RS10050 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HEC75_RS10075 ENOG4107SRH Nad-dependent epimerase dehydratase HEC75_RS10080 ENOG4105EQ1 Transcriptional regulator HEC75_RS10090 ENOG4105CUB amino acid HEC75_RS10095 ENOG4105CJB Exodeoxyribonuclease I HEC75_RS10110 ENOG4108J2R molybdopterin oxidoreductase HEC75_RS10115 ENOG4105QAX Iron-sulfur HEC75_RS10120 ENOG4108NWD Cytochrome HEC75_RS10125 ENOG4105DZ1 carboxypeptidase HEC75_RS10130 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HEC75_RS10135 ENOG4105DR8 Membrane HEC75_RS10140 ENOG41090HJ UPF0265 protein HEC75_RS10145 ENOG4105JZC GHMP kinase HEC75_RS10150 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEC75_RS10155 ENOG4105KTW ethanolamine utilization protein HEC75_RS10160 ENOG4105M3W utilization protein HEC75_RS10170 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HEC75_RS10175 ENOG4105C0A alcohol dehydrogenase HEC75_RS10180 ENOG4108EKI Dehydrogenase HEC75_RS10190 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HEC75_RS10200 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HEC75_RS10210 ENOG4105KNY Microcompartments protein HEC75_RS10220 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HEC75_RS10225 ENOG4108ZFT Dehydratase small subunit HEC75_RS10230 ENOG4105YCI dehydratase medium subunit HEC75_RS10235 ENOG4105DMB glycerol dehydratase HEC75_RS10240 ENOG4105EHR propanediol utilization protein pduB HEC75_RS10245 ENOG4105KNY Microcompartments protein HEC75_RS10250 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEC75_RS10255 ENOG4107XVH Transcriptional regulator HEC75_RS10260 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEC75_RS10265 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HEC75_RS10270 ENOG41081F0 Precorrin-8x methylmutase HEC75_RS10280 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HEC75_RS10285 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HEC75_RS10290 ENOG4105CIA precorrin-4 C(11)-methyltransferase HEC75_RS10295 ENOG4108P62 biosynthesis protein (CbiG) HEC75_RS10300 ENOG4105E4R Precorrin-3B C17-methyltransferase HEC75_RS10305 ENOG4105QUC reductase HEC75_RS10310 ENOG4107PPM cobalt chelatase HEC75_RS10315 ENOG4105DVK Precorrin-2 c20-methyltransferase HEC75_RS10320 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEC75_RS10325 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEC75_RS10330 ENOG4108V4M Cobalt abc transporter HEC75_RS10335 ENOG4108JJB ABC transporter HEC75_RS10345 ENOG4108YZT Adenosylcobinamide kinase HEC75_RS10360 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC75_RS10370 ENOG4105UQX Mate efflux family protein HEC75_RS10390 ENOG4105HVQ Regulatory factor of maltose metabolism HEC75_RS10425 ENOG4105FYV Amp nucleosidase HEC75_RS10430 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HEC75_RS10435 ENOG4105KVH Transcriptional regulator HEC75_RS10495 ENOG4108YX2 DNA-binding protein HEC75_RS10595 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HEC75_RS10605 ENOG4105DFP Integrase HEC75_RS10615 ENOG4105KT5 UmuD protein HEC75_RS10620 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEC75_RS10635 ENOG4105FCK Membrane HEC75_RS10640 ENOG4105Y0K Inner membrane protein YedR HEC75_RS10645 ENOG4105EST Metal Dependent Phosphohydrolase HEC75_RS10650 ENOG4105DVF Cytosine-specific methyltransferase HEC75_RS10655 ENOG41090BB DNA mismatch endonuclease (vsr) HEC75_RS10660 ENOG4105FDR Membrane HEC75_RS10665 ENOG4105CKW Inner membrane protein yedI HEC75_RS10670 ENOG4105VNZ cytoplasmic protein HEC75_RS10680 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase HEC75_RS10685 ENOG4105YX3 cellular response to acidity HEC75_RS10695 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HEC75_RS10700 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HEC75_RS10705 ENOG4105VS8 Flagellar biosynthetic protein fliq HEC75_RS10710 ENOG4105CN7 Flagellar biosynthetic protein FliP HEC75_RS10715 ENOG4105K0P flagellar biosynthesis protein HEC75_RS10720 ENOG4105DD5 Flagellar motor switch protein HEC75_RS10725 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HEC75_RS10730 ENOG4107ZI8 flagellar basal body-associated protein flil HEC75_RS10735 ENOG4105WF4 Flagellar hook-length control protein HEC75_RS10740 ENOG4105GSA Flagellar export protein flij HEC75_RS10745 ENOG4108JIR Flagellum-specific ATP synthase HEC75_RS10750 ENOG41090PJ Flagellar assembly protein HEC75_RS10755 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HEC75_RS10760 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HEC75_RS10780 ENOG41066VF YeeE YedE family protein HEC75_RS10785 ENOG4105JCU Inherit from NOG: (Lipo)protein HEC75_RS10790 ENOG4105E5K Alpha-amylase HEC75_RS10800 ENOG4105MQ3 flagellar protein FliS HEC75_RS10805 ENOG4105DTS flagellar hook-associated HEC75_RS10820 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC75_RS10825 ENOG4108M9K flagella biosynthesis protein FliZ HEC75_RS10830 ENOG4105EAB amino acid AbC transporter HEC75_RS10840 ENOG4105E5Q amino acid AbC transporter HEC75_RS10845 ENOG4105CDA abc transporter atp-binding protein HEC75_RS10850 ENOG4105VJY transcriptional regulator HEC75_RS10855 ENOG4105XVG cytoplasmic protein HEC75_RS10865 ENOG4105WH1 Two component transcriptional regulator luxr family HEC75_RS10910 ENOG4106RHG Yeca family HEC75_RS10915 ENOG4105E0U tyrosine-specific transport protein HEC75_RS10920 ENOG4105VVZ metal-binding protein HEC75_RS10925 ENOG41090A1 ferritin HEC75_RS10930 ENOG4105P23 (LipO)protein HEC75_RS10940 ENOG4108UEC Ferritin-like protein HEC75_RS10955 ENOG4108K4C ec 3.1.3.12 HEC75_RS10965 ENOG4108VA4 Universal stress protein HEC75_RS10975 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HEC75_RS10980 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HEC75_RS10985 ENOG4107RD7 Flagellar Motor Protein, MotA HEC75_RS10990 ENOG4105ER2 Ompa motb domain protein HEC75_RS10995 ENOG4105CBS Chea signal transduction histidine kinase HEC75_RS11000 ENOG4108V3W Chemotaxis protein, CheW HEC75_RS11005 ENOG4105C8Q Methyl-accepting chemotaxis HEC75_RS11010 ENOG4105BZU Histidine kinase HEC75_RS11020 ENOG4108VYJ response regulator receiver protein HEC75_RS11025 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HEC75_RS11030 ENOG4105D00 flagellar biosynthetic protein flhB HEC75_RS11035 ENOG4105D7B Flagellar biosynthesis protein flha HEC75_RS11040 ENOG4105IRD Flagellar protein FlhE HEC75_RS11045 ENOG4105F5H Glycosyl Hydrolase Family 88 HEC75_RS11060 ENOG4106ZCM YecM protein HEC75_RS11080 ENOG4105WJG Glutathione HEC75_RS11085 ENOG41081XQ Conserved Protein HEC75_RS11090 ENOG4105D3W isochorismatase HEC75_RS11100 ENOG4108TIT dATP pyrophosphohydrolase HEC75_RS11105 ENOG4105CDY transcriptional regulatory protein HEC75_RS11115 ENOG4107S01 Repressor protein MetJ HEC75_RS11135 ENOG4105FAV ABC, transporter HEC75_RS11140 ENOG4105FDK ABC transporter HEC75_RS11145 ENOG4105NXV High-affinity zinc uptake system protein HEC75_RS11150 ENOG4105DR5 peptidase HEC75_RS11155 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HEC75_RS11160 ENOG4105CA9 Pyruvate kinase HEC75_RS11165 ENOG4106KNT transcriptional regulator HEC75_RS11170 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HEC75_RS11175 ENOG4105C01 Dihydroxy-acid dehydratase HEC75_RS11180 ENOG4108UHU Aldolase HEC75_RS11185 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HEC75_RS11190 ENOG4105X2V dna damage-inducible protein HEC75_RS11200 ENOG4108Q2J Inner membrane protein YebE HEC75_RS11205 ENOG4105CUG Oligopeptidase b HEC75_RS11210 ENOG4105UMD exodeoxyribonuclease X HEC75_RS11215 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HEC75_RS11220 ENOG4105MPK DNA polymerase III subunit theta HEC75_RS11225 ENOG4105FXM Copper resistance protein HEC75_RS11230 ENOG4108PNC copper resistance HEC75_RS11235 ENOG4105NKT exported protein HEC75_RS11240 ENOG4108I1J Integrase HEC75_RS11305 ENOG41064WM Uncharacterized protein YcgX HEC75_RS11310 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling HEC75_RS11320 ENOG4108R1E Serine threonine protein phosphatase 1 HEC75_RS11325 ENOG4105UVW uncharacterized protein yebW HEC75_RS11330 ENOG4105WT8 Protein of unknown function (DUF1480) HEC75_RS11340 ENOG4105DY2 Paraquat-inducible protein b HEC75_RS11345 ENOG4105H2K paraquat-inducible protein a HEC75_RS11350 ENOG4108ZGC gaf domain protein HEC75_RS11360 ENOG4105CN1 protease HEC75_RS11365 ENOG4105D0M Protease HtpX homolog HEC75_RS11370 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC75_RS11375 ENOG4105J4Q Transcriptional regulator HEC75_RS11385 ENOG4106CCY Protein MgrB homolog HEC75_RS11390 ENOG4105Q3Y exported protein HEC75_RS11405 ENOG4105CJN penicillin-binding protein HEC75_RS11410 ENOG4105DHI Methyltransferase HEC75_RS11425 ENOG4105F3R pts system mannose fructose sorbose family iid HEC75_RS11430 ENOG4105ETZ PTS System HEC75_RS11435 ENOG4105DAS pts system HEC75_RS11440 ENOG4105EE5 Membrane protein terC HEC75_RS11445 ENOG4107XTP (EAL) domain protein HEC75_RS11450 ENOG4105EJQ L-serine dehydratase HEC75_RS11460 ENOG4105CRQ synthase (Component I) HEC75_RS11465 ENOG4105X5C UPF0181 protein HEC75_RS11470 ENOG4105M4H endoribonuclease L-psp HEC75_RS11475 ENOG4105DVT helicase HEC75_RS11480 ENOG41072GX Peptidase M22 Glycoprotease HEC75_RS11485 ENOG4105Y4Z Outer Membrane Lipoprotein HEC75_RS11490 ENOG4105CEY Amp-dependent synthetase and ligase HEC75_RS11495 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HEC75_RS11505 ENOG4107QMS site-determining protein HEC75_RS11520 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HEC75_RS11535 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HEC75_RS11545 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HEC75_RS11560 ENOG4105ED1 spovr family HEC75_RS11570 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEC75_RS11580 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HEC75_RS11590 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HEC75_RS11605 ENOG4105D82 Glutamate dehydrogenase HEC75_RS11615 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEC75_RS11620 ENOG4105C4M (Ubiquinol oxidase) subunit I HEC75_RS11625 ENOG4105MVP hydrogenase-1 operon protein HyaF HEC75_RS11630 ENOG4108VXY Hydrogenase-1 operon protein HyaE HEC75_RS11635 ENOG4108USZ hydrogenase HEC75_RS11640 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HEC75_RS11710 ENOG4105HVQ Regulatory factor of maltose metabolism HEC75_RS11725 ENOG4108XS9 dna repair protein HEC75_RS11735 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HEC75_RS11770 ENOG4105DB4 HEC75_RS11775 ENOG41065RQ ADP-ribosylation crystallin J1 HEC75_RS11810 ENOG4105F9F transposase HEC75_RS11820 ENOG4105DFP Integrase HEC75_RS11825 ENOG4105C3G gtp-binding protein HEC75_RS11835 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HEC75_RS11840 ENOG4105CHH sulfate transporter HEC75_RS11845 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEC75_RS11860 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HEC75_RS11870 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEC75_RS11875 ENOG4108YY7 Invasion gene expression up-regulator SirB HEC75_RS11880 ENOG41063JG Transcriptional regulator HEC75_RS11890 ENOG4105EWV Sodium calcium exchanger membrane region HEC75_RS11895 ENOG4105WS7 Cation transport regulator HEC75_RS11900 ENOG41090EX DsrE family HEC75_RS11905 ENOG4105ID0 Putative invasin HEC75_RS11910 ENOG4105WH1 Two component transcriptional regulator luxr family HEC75_RS11915 ENOG4105BZU Histidine kinase HEC75_RS11920 ENOG4105DQQ Major facilitator superfamily MFS_1 HEC75_RS11925 ENOG4105CRU nitrate reductase, alpha subunit HEC75_RS11930 ENOG4108IUE nitrate reductase beta subunit HEC75_RS11935 ENOG4105R3A Nitrate reductase HEC75_RS11940 ENOG41076YT nitrate reductase, gamma subunit HEC75_RS11970 ENOG4105CIY formyltetrahydrofolate deformylase HEC75_RS11980 ENOG4105D78 K07001 NTE family protein HEC75_RS11985 ENOG4105I93 response regulator HEC75_RS11990 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEC75_RS12005 ENOG4105C0A alcohol dehydrogenase HEC75_RS12010 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HEC75_RS12015 ENOG4107QSI ABC, transporter HEC75_RS12020 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC75_RS12025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEC75_RS12030 ENOG4105C3U ABC transporter HEC75_RS12035 ENOG4108JQ7 (ABC) transporter HEC75_RS12040 ENOG4105EYW Ion transport protein HEC75_RS12060 ENOG4105K9H YciI-like protein HEC75_RS12065 ENOG410822N TonB family HEC75_RS12070 ENOG4105NAU thioesterase Superfamily protein HEC75_RS12085 ENOG4105PI0 Ferredoxin HEC75_RS12090 ENOG4105EIF outer membrane protein W HEC75_RS12095 ENOG4105WEF catalase HEC75_RS12100 ENOG4108N8X transition metal ion binding HEC75_RS12105 ENOG4108Z9Z response to DNA damage stimulus HEC75_RS12125 ENOG4105DK0 Indole-3-glycerol phosphate synthase HEC75_RS12130 ENOG4108EFP Anthranilate synthase component II HEC75_RS12135 ENOG4105CRQ synthase (Component I) HEC75_RS12145 ENOG4105DB7 PHP domain protein HEC75_RS12150 ENOG4107RTD sua5 ycio yrdc ywlc family protein HEC75_RS12155 ENOG4105FE9 pseudouridine synthase HEC75_RS12160 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HEC75_RS12165 ENOG4105UBK short-chain dehydrogenase reductase HEC75_RS12170 ENOG4105ERU peptidase HEC75_RS12175 ENOG4105RKX Protein of unknown function (DUF2498) HEC75_RS12180 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEC75_RS12185 ENOG4107R11 Transcriptional regulator HEC75_RS12200 ENOG4107QM5 aconitate hydratase HEC75_RS12205 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HEC75_RS12210 ENOG4105EYK Phosphatidylglycerophosphatase B HEC75_RS12215 ENOG4105Q4A inner membrane protein yciS HEC75_RS12220 ENOG4105CFV Tetratricopeptide repeat protein HEC75_RS12230 ENOG4108ZJT translation initiation factor, Sui1 HEC75_RS12235 ENOG41061RM osmotically inducible lipoprotein HEC75_RS12240 ENOG4105N2W Transcriptional regulator HEC75_RS12250 ENOG4105BZU Histidine kinase HEC75_RS12260 ENOG4105Q4T oxidoreductase HEC75_RS12265 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HEC75_RS12290 ENOG4108JQ2 peptide transport system atp-binding protein HEC75_RS12295 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HEC75_RS12300 ENOG4108EU3 peptide transport system, permease HEC75_RS12340 ENOG4108EKA peptide transport system, permease HEC75_RS12345 ENOG4108J59 Extracellular solute-binding protein, family 5 HEC75_RS12350 ENOG4105E51 psp operon transcriptional activator HEC75_RS12355 ENOG41087YS Phage shock protein A HEC75_RS12360 ENOG4105YYT phage shock protein B HEC75_RS12365 ENOG4105FM1 phage shock protein C HEC75_RS12370 ENOG4105NNG Peripheral inner membrane phage-shock protein HEC75_RS12375 ENOG4105K8Z Phage shock protein HEC75_RS12380 ENOG4105CM6 amino acid regulated cytosolic protein HEC75_RS12390 ENOG4108JU8 Transcriptional regulator HEC75_RS12395 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HEC75_RS12400 ENOG4107S8C mandelate racemase muconate lactonizing HEC75_RS12405 ENOG4105KXI murein peptide amidase A HEC75_RS12410 ENOG4107QSI ABC, transporter HEC75_RS12420 ENOG4105HEI LysR family (Transcriptional regulator HEC75_RS12425 ENOG4105CV8 reductase HEC75_RS12430 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HEC75_RS12435 ENOG4108XFH Transcriptional regulator HEC75_RS12450 ENOG4106PHM regulatory protein HEC75_RS12470 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HEC75_RS12490 ENOG4105D64 Mechanosensitive ion channel HEC75_RS12495 ENOG4105S5I Membrane HEC75_RS12500 ENOG4105Q9Y Universal stress protein HEC75_RS12505 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HEC75_RS12510 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEC75_RS12515 ENOG4108DG9 Smr protein MutS2 HEC75_RS12520 ENOG4105C8Q Methyl-accepting chemotaxis HEC75_RS12530 ENOG4105C1J atp-dependent rna helicase HEC75_RS12550 ENOG410814C multidrug resistance protein HEC75_RS12555 ENOG4108RW8 Universal stress protein F HEC75_RS12560 ENOG4108RS6 transposase HEC75_RS12565 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HEC75_RS12575 ENOG4105IKK cytoplasmic protein HEC75_RS12580 ENOG41090X5 Heat shock protein hslJ HEC75_RS12585 ENOG4105C5I Dehydrogenase HEC75_RS12590 ENOG4107H52 Dicarboxylate transport HEC75_RS12595 ENOG410689M (LipO)protein HEC75_RS12600 ENOG4105WXT Conserved Protein HEC75_RS12615 ENOG4105CQ7 ATP-dependent helicase HEC75_RS12620 ENOG4107DB1 DUF218 domain HEC75_RS12625 ENOG4105CPW cytochrome b561 HEC75_RS12630 ENOG4108WF3 methyltransferase HEC75_RS12640 ENOG4105E5Q amino acid AbC transporter HEC75_RS12650 ENOG4105E5Q amino acid AbC transporter HEC75_RS12655 ENOG4107R0W ABC transporter HEC75_RS12665 ENOG4107ZUJ lipid metabolic process HEC75_RS12690 ENOG4105C8Q Methyl-accepting chemotaxis HEC75_RS12695 ENOG4105DDW LysR family Transcriptional regulator HEC75_RS12700 ENOG4105E32 cytoplasmic protein HEC75_RS12705 ENOG4105EBR Carboxylesterase HEC75_RS12710 ENOG4105DJ9 glucan biosynthesis protein HEC75_RS12715 ENOG4108YYC ycei family HEC75_RS12730 ENOG4108PQ7 sgc region transcriptional regulator HEC75_RS12735 ENOG4108RK0 3-epimerase HEC75_RS12740 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HEC75_RS12745 ENOG4106P19 photosystem i assembly btpa HEC75_RS12750 ENOG4105DT3 PTS system, galactitol-specific IIc component HEC75_RS12755 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HEC75_RS12760 ENOG4105CN9 Peptidase m42 family protein HEC75_RS12765 ENOG4108Z9I -acetyltransferase HEC75_RS12770 ENOG4107WE3 acetyltransferase YdcK HEC75_RS12775 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HEC75_RS12780 ENOG41088CC tellurite resistance protein tehB HEC75_RS12785 ENOG4108KKZ (LipO)protein HEC75_RS12790 ENOG4105DKK Benzoate HEC75_RS12795 ENOG4108JCI Transcriptional regulator HEC75_RS12800 ENOG4105CFP Peptidase U32 HEC75_RS12805 ENOG4105RR0 Protein of unknown function (DUF2554) HEC75_RS12825 ENOG4108UQS dipeptidase HEC75_RS12830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEC75_RS12845 ENOG410654E Membrane HEC75_RS12865 ENOG4105R71 cytoplasmic protein HEC75_RS12870 ENOG4108T9Y Inner membrane protein ydcZ HEC75_RS12875 ENOG4108Z7F N-acetyltransferase HEC75_RS12880 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEC75_RS12885 ENOG4108WYP Transcriptional regulator HEC75_RS12890 ENOG4105CHB tonB-dependent Receptor HEC75_RS12895 ENOG4108NS2 receptor HEC75_RS12900 ENOG4105SUV lipoprotein YgdR HEC75_RS12905 ENOG4105C85 amino acid HEC75_RS12915 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HEC75_RS12920 ENOG4105JAB phenazine biosynthesis protein, phzf family HEC75_RS12925 ENOG4105D0D Nitrate reductase 2, gamma subunit HEC75_RS12930 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HEC75_RS12935 ENOG4108IUE nitrate reductase beta subunit HEC75_RS12940 ENOG4105CRU nitrate reductase, alpha subunit HEC75_RS12945 ENOG4107QND Nitrite extrusion protein HEC75_RS12980 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC75_RS12985 ENOG4108MG3 formate dehydrogenase HEC75_RS12990 ENOG4105DQ4 alcohol dehydrogenase HEC75_RS13005 ENOG4105TPS biofilm-dependent modulation protein HEC75_RS13010 ENOG4108Z9K Osmotically inducible protein HEC75_RS13015 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HEC75_RS13025 ENOG4105XXV Acid-resistance protein HEC75_RS13035 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HEC75_RS13050 ENOG4105C87 Aminotransferase class I and II HEC75_RS13055 ENOG4105DFD Na H antiporter HEC75_RS13060 ENOG41060NJ transcriptional regulator HEC75_RS13100 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HEC75_RS13125 ENOG4108I5G Major Facilitator superfamily HEC75_RS13130 ENOG4105CPQ Dehydrogenase HEC75_RS13135 ENOG4105C6F GntR Family Transcriptional Regulator HEC75_RS13150 ENOG4105DPX Hydrogenase, large subunit HEC75_RS13155 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HEC75_RS13175 ENOG4105MVP hydrogenase-1 operon protein HyaF HEC75_RS13200 ENOG4105FFC UPF0187 protein HEC75_RS13205 ENOG4105M0C cytoplasmic protein HEC75_RS13215 ENOG4105C26 Dehydrogenase HEC75_RS13220 ENOG4105EGI Transcriptional regulator HEC75_RS13235 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEC75_RS13240 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HEC75_RS13245 ENOG4106DNR multiple antibiotic resistance protein HEC75_RS13250 ENOG4108594 Permease of the drug metabolite transporter HEC75_RS13255 ENOG4105E5W Transporter HEC75_RS13265 ENOG4108YDI single-species biofilm formation on inanimate substrate HEC75_RS13270 ENOG4108WTK competence damage-inducible protein HEC75_RS13280 ENOG4105DGW oligopeptidase A HEC75_RS13285 ENOG4105EMU Dehydrogenase HEC75_RS13290 ENOG4107XBN GntR Family Transcriptional Regulator HEC75_RS13295 ENOG41061EV selenium-binding protein YdfZ HEC75_RS13300 ENOG4105DEI Mannitol dehydrogenase HEC75_RS13310 ENOG4105CPQ Dehydrogenase HEC75_RS13330 ENOG4108MK9 spermidine N(1)-acetyltransferase HEC75_RS13340 ENOG4105KBG Protein of unknown function (DUF1161) HEC75_RS13345 ENOG4107QY8 reductase HEC75_RS13350 ENOG4105C3J Cysteine desulfurase HEC75_RS13355 ENOG4105QAX Iron-sulfur HEC75_RS13360 ENOG4107KGK dmso reductase anchor subunit HEC75_RS13365 ENOG4108NEM leader-binding protein dmsD HEC75_RS13370 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HEC75_RS13375 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HEC75_RS13380 ENOG4105E90 ABC transporter HEC75_RS13385 ENOG4108IJ8 ABC transporter HEC75_RS13395 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HEC75_RS13400 ENOG4105DAG ROK family HEC75_RS13405 ENOG4106NZI LysR family Transcriptional regulator HEC75_RS13410 ENOG4105D94 Major Facilitator Superfamily HEC75_RS13420 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HEC75_RS13435 ENOG4105DSF transport protein HEC75_RS13440 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HEC75_RS13445 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HEC75_RS13450 ENOG4105C5D exported protein HEC75_RS13455 ENOG4105D5Q Arginine ornithine antiporter HEC75_RS13460 ENOG4105RA2 Membrane HEC75_RS13465 ENOG4107EXC regulatoR HEC75_RS13475 ENOG4105FCK Membrane HEC75_RS13480 ENOG4105CPN adenine deaminase HEC75_RS13485 ENOG4105JJR Histidine kinase HEC75_RS13495 ENOG4105C9Q fumarate hydratase class II HEC75_RS13500 ENOG4107GFK fumarate HEC75_RS13505 ENOG4105EIP mannose-6-phosphate isomerase HEC75_RS13510 ENOG4106J39 exported protein HEC75_RS13525 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEC75_RS13530 ENOG4105D9R oxidoreductase HEC75_RS13535 ENOG4106C6R beta-lactam resistance protein HEC75_RS13545 ENOG4105M9B inner membrane protein ydgK HEC75_RS13570 ENOG4108UQQ Electron transport complex HEC75_RS13580 ENOG4105CSM endonuclease III HEC75_RS13585 ENOG4105DUX Transporter HEC75_RS13590 ENOG4108K3A Glutathione S-transferase HEC75_RS13610 ENOG410642K Lysozyme inhibitor HEC75_RS13620 ENOG4108XTF Outer Membrane Lipoprotein HEC75_RS13635 ENOG4105Y49 secretion protein, HlyD family HEC75_RS13640 ENOG4105DSW Fusaric acid resistance protein HEC75_RS13645 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEC75_RS13650 ENOG4107RGM aldo keto reductase HEC75_RS13655 ENOG4105XZD Fe-S protein HEC75_RS13660 ENOG4108WUH Transcriptional regulator, TetR family HEC75_RS13665 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEC75_RS13670 ENOG4108UYE Lactoylglutathione lyase HEC75_RS13675 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HEC75_RS13680 ENOG4105M2J Glutaredoxin HEC75_RS13685 ENOG4105K4H Nlp p60 protein HEC75_RS13690 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEC75_RS13705 ENOG4105F52 Transcriptional regulator HEC75_RS13710 ENOG4105CZQ inner membrane transport protein YdhC HEC75_RS13715 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEC75_RS13720 ENOG4108R6K riboflavin synthase, subunit alpha HEC75_RS13740 ENOG4108IUF type iii secretion HEC75_RS13745 ENOG4108TN6 type iii secretion HEC75_RS13750 ENOG41083GP type iii secretion HEC75_RS13755 ENOG4108HHI Type III secretion system protein HEC75_RS13760 ENOG41063Q7 Type III secretion system protein HEC75_RS13775 ENOG4108JIR Flagellum-specific ATP synthase HEC75_RS13785 ENOG4106H1D secretion system apparatus protein HEC75_RS13790 ENOG4105UQF type iii secretion HEC75_RS13795 ENOG4106563 type III secretion system apparatus protein HEC75_RS13845 ENOG4106FZW pathogenicity island effector protein HEC75_RS13850 ENOG4108SZ7 secretion system effector HEC75_RS13860 ENOG4105ZQI secreted protein HEC75_RS13895 ENOG4105BZU Histidine kinase HEC75_RS13905 ENOG4108XDN Transcriptional regulator HEC75_RS13910 ENOG4107SEY Conserved Protein HEC75_RS13915 ENOG4105RFR Protein of unknown function (DUF2767) HEC75_RS13920 ENOG4108ZXC Two component transcriptional regulator, luxr family HEC75_RS13925 ENOG4106AFQ Histidine kinase HEC75_RS13930 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC75_RS13935 ENOG4106WHD Tetrathionate reductase HEC75_RS13940 ENOG4105DB1 molybdopterin oxidoreductase HEC75_RS13945 ENOG4108RVA ribokinase HEC75_RS13955 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) HEC75_RS13960 ENOG4105CUB amino acid HEC75_RS13965 ENOG4105CA9 Pyruvate kinase HEC75_RS13985 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC75_RS14000 ENOG4105JRK feS assembly protein SufD HEC75_RS14005 ENOG4105C3K feS assembly ATPase SufC HEC75_RS14010 ENOG4105DIW FeS assembly protein SUFB HEC75_RS14015 ENOG4108Z4V iron-sulfur cluster assembly HEC75_RS14020 ENOG4108ETY sodium dicarboxylate symporter HEC75_RS14025 ENOG410671Z uncharacterized protein ydiH HEC75_RS14030 ENOG4105KA0 thioesterase Superfamily protein HEC75_RS14035 ENOG4105CQB FAD linked oxidase domain protein HEC75_RS14040 ENOG4105IPI Membrane HEC75_RS14050 ENOG4105SUA Ydil protein HEC75_RS14055 ENOG4105EMV Major Facilitator HEC75_RS14060 ENOG4105EMV Major Facilitator HEC75_RS14075 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HEC75_RS14080 ENOG4105C1G acyl-Coa dehydrogenase HEC75_RS14085 ENOG4105W4W Transcriptional regulator HEC75_RS14090 ENOG4105CV7 Electron transfer flavoprotein HEC75_RS14095 ENOG4105C10 Electron transfer flavoprotein HEC75_RS14100 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HEC75_RS14105 ENOG41090P5 ferredoxin-like protein HEC75_RS14110 ENOG4105CEY Amp-dependent synthetase and ligase HEC75_RS14115 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HEC75_RS14125 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC75_RS14150 ENOG4108QBX (LipO)protein HEC75_RS14160 ENOG4108V06 Glutathione peroxidase HEC75_RS14170 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HEC75_RS14175 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HEC75_RS14195 ENOG41082NX 50s ribosomal protein l35 HEC75_RS14200 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HEC75_RS14210 ENOG4105K25 O-Antigen polymerase HEC75_RS14235 ENOG4108NE3 Salt-induced outer membrane protein HEC75_RS14240 ENOG4105DE4 1-phosphofructokinase HEC75_RS14245 ENOG4105P10 Uncharacterized protein ydiZ HEC75_RS14255 ENOG4107PN8 YfeABCD locus regulator HEC75_RS14260 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HEC75_RS14265 ENOG4107K5X Membrane-bound metal-dependent hydrolase HEC75_RS14270 ENOG4108ETY sodium dicarboxylate symporter HEC75_RS14280 ENOG4105CH6 catalase HEC75_RS14305 ENOG4105VCP PTS System HEC75_RS14310 ENOG4105CK1 PTS System HEC75_RS14315 ENOG4105VZJ PTS System HEC75_RS14320 ENOG4105KKI DNA-binding transcriptional activator OsmE HEC75_RS14330 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HEC75_RS14335 ENOG4108SPG Periplasmic Protein HEC75_RS14350 ENOG4105C26 Dehydrogenase HEC75_RS14365 ENOG4105CGK Exodeoxyribonuclease III HEC75_RS14370 ENOG4105M6F mutator MutT protein HEC75_RS14375 ENOG4105MTM Protein of unknown function (DUF1496) HEC75_RS14380 ENOG4105D82 Glutamate dehydrogenase HEC75_RS14385 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEC75_RS14390 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HEC75_RS14395 ENOG41069NU Nitroreductase HEC75_RS14400 ENOG4105D07 Signal peptide peptidase, SppA HEC75_RS14405 ENOG4105HDK L-asparaginase HEC75_RS14410 ENOG4108RWI nicotinamidase HEC75_RS14415 ENOG4105VUT cytoplasmic protein HEC75_RS14425 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEC75_RS14430 ENOG4105DSB aldose 1-epimerase HEC75_RS14435 ENOG4105CV8 reductase HEC75_RS14440 ENOG4105C4X radical SAM domain protein HEC75_RS14445 ENOG4105GNX MltA-interacting MipA family protein HEC75_RS14450 ENOG4105CYN Serine protein kinase HEC75_RS14465 ENOG4108KHP Diguanylate cyclase HEC75_RS14470 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HEC75_RS14485 ENOG4105R1U AraC Family Transcriptional Regulator HEC75_RS14490 ENOG4105DJ2 Major Facilitator Superfamily HEC75_RS14495 ENOG4105K78 MarR family Transcriptional regulator HEC75_RS14505 ENOG4105UCG Domain of unknown function (DUF333) HEC75_RS14510 ENOG4106G4W HEC75_RS14515 ENOG4105Y3U Transglycosylase-associated protein HEC75_RS14525 ENOG4105YP6 Domain of unknown function (DUF1869) HEC75_RS14530 ENOG4108YS1 cytoplasmic protein HEC75_RS14540 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HEC75_RS14555 ENOG4108Z6Z Transcriptional regulator HEC75_RS14570 ENOG4108MEK Metal-binding protein YodA HEC75_RS14585 ENOG4105D64 Mechanosensitive ion channel HEC75_RS14590 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HEC75_RS14595 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HEC75_RS14620 ENOG4108VKM cytochrome b561 HEC75_RS14630 ENOG4108ZNX Heat shock protein HEC75_RS14655 ENOG4105H38 Membrane HEC75_RS14665 ENOG41060EU Cold shock-like protein HEC75_RS14670 ENOG4106F2Y RICIN HEC75_RS14675 ENOG4105Y50 Virulence Protein HEC75_RS14680 ENOG4108TMH cytolethal distending toxin HEC75_RS14710 ENOG4108RS6 transposase HEC75_RS14715 ENOG4108HMX isocitrate dehydrogenase (NADP) HEC75_RS14720 ENOG4108R99 pseudouridine synthase HEC75_RS14745 ENOG4107QTF adenylosuccinate lyase HEC75_RS14760 ENOG4105EZE Cupin 4 family protein HEC75_RS14775 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEC75_RS14790 ENOG4105D38 putrescine abc transporter HEC75_RS14795 ENOG4108HM4 ABC transporter HEC75_RS14800 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HEC75_RS14810 ENOG4105D60 lipoprotein releasing system transmembrane protein HEC75_RS14815 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEC75_RS14820 ENOG4105D60 lipoprotein releasing system transmembrane protein HEC75_RS14825 ENOG4108JA2 transcriptioN-repair coupling factor HEC75_RS14830 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC75_RS14835 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HEC75_RS14840 ENOG4108IND Tetr family transcriptional regulator HEC75_RS14845 ENOG4107MBR 17 kDa surface antigen HEC75_RS14850 ENOG4105CEP NADH dehydrogenase HEC75_RS14870 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HEC75_RS14875 ENOG41090DQ Lipoprotein HEC75_RS14880 ENOG4105K59 histidine triad (HIT) protein HEC75_RS14885 ENOG4105CNM Receptor HEC75_RS14890 ENOG4105CI1 PTS System HEC75_RS14895 ENOG4105F8V Hydrolase, tatD family HEC75_RS14900 ENOG4107QRG dna polymerase iii HEC75_RS14910 ENOG4105HHA aminodeoxychorismate lyase HEC75_RS14915 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HEC75_RS14920 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEC75_RS14925 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEC75_RS14930 ENOG4105CHR reductase HEC75_RS14935 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HEC75_RS14940 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEC75_RS14955 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HEC75_RS14965 ENOG4105EI2 Pseudouridine synthase HEC75_RS14970 ENOG4107QQB Ribonuclease E HEC75_RS14975 ENOG4105DTJ flagellar hook-associated protein HEC75_RS14980 ENOG4105E1Q flagellar hook-associated protein HEC75_RS14985 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HEC75_RS15000 ENOG4105CGA flagellar basal-body rod protein FlgG HEC75_RS15005 ENOG4108KPB Flagellar basal-body rod protein FlgF HEC75_RS15010 ENOG4105BZE flagellar hook protein, FlgE HEC75_RS15015 ENOG4105W00 Flagellar hook capping protein HEC75_RS15020 ENOG4108ZC9 flagellar basal-body rod protein flgc HEC75_RS15025 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HEC75_RS15030 ENOG4105CKS Flagella basal body P-ring formation protein flgA HEC75_RS15035 ENOG4105M9M anti-sigma28 factor FlgM HEC75_RS15040 ENOG4105QVD Flagella synthesis protein FlgN HEC75_RS15045 ENOG4105CJR Integral membrane protein (MviN HEC75_RS15050 ENOG4105EP9 oxidoreductase HEC75_RS15060 ENOG4105D9U N-acetyltransferase HEC75_RS15070 ENOG4105E9S glutaredoxin 2 HEC75_RS15075 ENOG4105F3T (LipO)protein HEC75_RS15085 ENOG4105MEA DNA damage-inducible protein i HEC75_RS15090 ENOG4105PVA Biofilm formation regulatory protein BssS HEC75_RS15100 ENOG4106974 biofilm formation HEC75_RS15105 ENOG4105DS1 cytochrome b561 HEC75_RS15110 ENOG4108YYC ycei family HEC75_RS15120 ENOG4105D1S lipid A biosynthesis HEC75_RS15130 ENOG4108W47 Acidic protein msyB HEC75_RS15135 ENOG4105NAC (LipO)protein HEC75_RS15140 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HEC75_RS15150 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HEC75_RS15155 ENOG4107RZC phospholipase d HEC75_RS15160 ENOG4108UVJ appr-1-p processing domain protein HEC75_RS15165 ENOG41068SS HEC75_RS15170 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HEC75_RS15175 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HEC75_RS15180 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HEC75_RS15185 ENOG41086KC Transcriptional regulator HEC75_RS15190 ENOG4108XDW curli assembly protein CsgE HEC75_RS15195 ENOG4108WYR Curli production assembly transport component, CsgF HEC75_RS15200 ENOG4105P8Q Curli production assembly transport component CsgG HEC75_RS15205 ENOG4108RS6 transposase HEC75_RS15210 ENOG4108UQ5 membrane protein YcdZ HEC75_RS15215 ENOG4107XHZ cytoplasmic chaperone TorD family protein HEC75_RS15285 ENOG4107RJ5 oxidoreductase HEC75_RS15290 ENOG4105JHE Major Facilitator Superfamily HEC75_RS15295 ENOG4108QGT oligogalacturonate-specific porin HEC75_RS15305 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HEC75_RS15310 ENOG4107RJ1 sodium solute HEC75_RS15315 ENOG4105QEK Transcriptional regulator HEC75_RS15320 ENOG4105D5M phosphate starvation-inducible protein HEC75_RS15325 ENOG4105CK7 Sodium proline symporter HEC75_RS15340 ENOG4108R86 Transcriptional regulator HEC75_RS15345 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HEC75_RS15350 ENOG4105CS1 NAD(P)H quinone oxidoreductase HEC75_RS15355 ENOG4105XH3 HEC75_RS15360 ENOG4105D6F Phosphatase HEC75_RS15365 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HEC75_RS15370 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEC75_RS15375 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HEC75_RS15430 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HEC75_RS15435 ENOG4105C26 Dehydrogenase HEC75_RS15445 ENOG4108V8F Transcriptional regulator, MarR family HEC75_RS15450 ENOG4105EFA 4-hydroxyphenylacetate HEC75_RS15455 ENOG4107UWN reductase HEC75_RS15460 ENOG4105VT2 5-hydroxyisourate hydrolase HEC75_RS15465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEC75_RS15470 ENOG4107ZY3 Histidine kinase HEC75_RS15485 ENOG4106YSC HEC75_RS15490 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell HEC75_RS15495 ENOG4106HNN Invasion protein HEC75_RS15505 ENOG41084BJ Pentapeptide repeat protein HEC75_RS15520 ENOG4108MN8 Membrane HEC75_RS15530 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HEC75_RS15540 ENOG4108V1U phospholipid-binding protein HEC75_RS15555 ENOG4105K4P CoA-binding domain protein HEC75_RS15565 ENOG4108Z5K methylglyoxal synthase HEC75_RS15570 ENOG41088T4 Helicase IV HEC75_RS15575 ENOG410901E Membrane HEC75_RS15580 ENOG4105EM2 membrane HEC75_RS15585 ENOG4108RZ1 DNA transformation protein HEC75_RS15595 ENOG4105UYK outer membrane protein a HEC75_RS15605 ENOG4105DAN ATP-dependent protease HEC75_RS15615 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HEC75_RS15620 ENOG4108Q2G (LipO)protein HEC75_RS15625 ENOG4105DY2 Paraquat-inducible protein b HEC75_RS15630 ENOG4105F1S paraquat-inducible protein a HEC75_RS15635 ENOG4105C5H ABC transporter HEC75_RS15645 ENOG4105QVC MOSC domain-containing protein HEC75_RS15650 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HEC75_RS15660 ENOG4105CD8 aminopeptidase N HEC75_RS15670 ENOG4105C5S asparaginyl-tRNA synthetase HEC75_RS15675 ENOG4105FCK Membrane HEC75_RS15680 ENOG4105CGF Aromatic amino acid aminotransferase HEC75_RS15685 ENOG4105C5X domain protein HEC75_RS15690 ENOG4105EAQ (twin-arginine translocation) pathway signal HEC75_RS15695 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HEC75_RS15705 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HEC75_RS15715 ENOG4106371 Methyltransferase HEC75_RS15720 ENOG4107S90 membrAne HEC75_RS15725 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HEC75_RS15740 ENOG4105T0Z Conserved Protein HEC75_RS15750 ENOG4105BZ1 (ABC) transporter HEC75_RS15755 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HEC75_RS15760 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HEC75_RS15765 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HEC75_RS15775 ENOG4108K0D peptidase, M48 HEC75_RS15790 ENOG4107VMU Membrane HEC75_RS15795 ENOG4105DDY UPF0142 protein ycaO HEC75_RS15800 ENOG4105TMB Formate nitrite transporter HEC75_RS15805 ENOG4105C6N Formate acetyltransferase HEC75_RS15810 ENOG4108RS6 transposase HEC75_RS15815 ENOG4105GUS HEC75_RS15820 ENOG4105F1A Pyruvate formate-lyase HEC75_RS15825 ENOG4105E5D amino acid HEC75_RS15835 ENOG4107KGK dmso reductase anchor subunit HEC75_RS15840 ENOG4105QAX Iron-sulfur HEC75_RS15845 ENOG4107QY8 reductase HEC75_RS15855 ENOG4105D1H recombination factor protein RarA HEC75_RS15865 ENOG4105CNU cell division protein FtsK HEC75_RS15870 ENOG4105EW9 transcriptional regulator AsnC family HEC75_RS15875 ENOG4105C3M thioredoxin reductase HEC75_RS15880 ENOG4108JJ9 ABC, transporter HEC75_RS15885 ENOG4108JJ8 (ABC) transporter HEC75_RS15900 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HEC75_RS15905 ENOG4105HEI LysR family (Transcriptional regulator HEC75_RS15910 ENOG4105EUB pirin domain protein HEC75_RS15915 ENOG4105CHJ isochorismatase hydrolase HEC75_RS15935 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC75_RS15945 ENOG4105VEQ Cold shock protein HEC75_RS15950 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEC75_RS15955 ENOG4105DJY efflux transporter, rnd family, mfp subunit HEC75_RS15960 ENOG4108MJ5 VirK protein HEC75_RS15965 ENOG4105CPB ATP-dependent endonuclease of the OLD family HEC75_RS15970 ENOG4105DWU Membrane HEC75_RS15980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEC75_RS15985 ENOG4105C7K acetolactate synthase HEC75_RS15990 ENOG4105C5W Aldolase HEC75_RS15995 ENOG4105CGD Nad-dependent epimerase dehydratase HEC75_RS16000 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HEC75_RS16005 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HEC75_RS16015 ENOG41064MM (LipO)protein HEC75_RS16020 ENOG4105E5Z arginine transporter ATP-binding subunit HEC75_RS16025 ENOG4106PMH Extracellular solute-binding protein family 3 HEC75_RS16030 ENOG4105GBT ABC transporter HEC75_RS16035 ENOG4105DMR ABC, transporter HEC75_RS16040 ENOG4106TNF Periplasmic binding protein HEC75_RS16065 ENOG4105RBQ inner membrane protein ybjO HEC75_RS16070 ENOG4105D38 putrescine abc transporter HEC75_RS16075 ENOG4105F38 ABC transporter, permease HEC75_RS16080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEC75_RS16085 ENOG4107RUE extracellular solute-binding protein family 1 HEC75_RS16090 ENOG4108RMJ sensory transduction regulator HEC75_RS16100 ENOG4108DBC nitroreductase HEC75_RS16105 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HEC75_RS16110 ENOG41090BQ Glutaredoxin HEC75_RS16115 ENOG4105GWF inner membrane protein YbjM HEC75_RS16125 ENOG4108RFG Tetr family transcriptional regulator HEC75_RS16130 ENOG4106UW1 Major Facilitator superfamily HEC75_RS16135 ENOG4108HCJ Hydrolase HEC75_RS16140 ENOG4107QF7 multi-drug HEC75_RS16145 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEC75_RS16150 ENOG4107FB0 transcriptional regulator DeoR family HEC75_RS16155 ENOG4105DZ1 carboxypeptidase HEC75_RS16160 ENOG4108TGY Glutathione S-transferase HEC75_RS16165 ENOG4105D8V Glucose sorbosone dehydrogenase HEC75_RS16170 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HEC75_RS16185 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC75_RS16190 ENOG4105DEF Extracellular solute-binding protein, family 5 HEC75_RS16195 ENOG4108JQ6 ABC transporter HEC75_RS16200 ENOG4105D44 asparaginase HEC75_RS16205 ENOG4105CVM Molybdenum cofactor synthesis domain protein HEC75_RS16210 ENOG4105D06 uba thif-type nad fad binding protein HEC75_RS16215 ENOG4105F1A Pyruvate formate-lyase HEC75_RS16225 ENOG4108HCJ Hydrolase HEC75_RS16230 ENOG41072TH Protein of unknown function (DUF1479) HEC75_RS16235 ENOG4105C5H ABC transporter HEC75_RS16240 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC75_RS16245 ENOG4105F4P )-transporter HEC75_RS16250 ENOG4105KST dependent repressor HEC75_RS16260 ENOG4108I6E Sulfatase HEC75_RS16265 ENOG4108T1M outer membrane protein x HEC75_RS16280 ENOG4107R0W ABC transporter HEC75_RS16285 ENOG4105E5Q amino acid AbC transporter HEC75_RS16290 ENOG4105CDA abc transporter atp-binding protein HEC75_RS16295 ENOG4105D8X mechanosensitive ion channel HEC75_RS16305 ENOG4105KSC Transcriptional regulator, TraR DksA family HEC75_RS16310 ENOG4105VR4 UPF0379 protein ybiJ HEC75_RS16315 ENOG4108MTB glycosyl transferase family HEC75_RS16320 ENOG4105DVT helicase HEC75_RS16325 ENOG4105C1J atp-dependent rna helicase HEC75_RS16330 ENOG4107MVR Transcriptional regulator HEC75_RS16335 ENOG4105D0S secretion protein (HlyD HEC75_RS16340 ENOG4105CJ1 ABC, transporter HEC75_RS16345 ENOG4107QWP ABC-2 type transporter HEC75_RS16350 ENOG4107QWP ABC-2 type transporter HEC75_RS16355 ENOG4105I9U inner membrane protein ybhQ HEC75_RS16360 ENOG4105X23 Endonuclease Exonuclease phosphatase HEC75_RS16365 ENOG4105DZQ phospholipase D Transphosphatidylase HEC75_RS16370 ENOG4107UXM Membrane HEC75_RS16385 ENOG4105HFZ Membrane HEC75_RS16390 ENOG4108ZAF Molybdopterin HEC75_RS16395 ENOG4105M00 molybdopterin converting factor, subunit 1 HEC75_RS16405 ENOG4108RIR Molybdenum cofactor biosynthesis protein HEC75_RS16415 ENOG4105CHW UPF0052 protein HEC75_RS16430 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HEC75_RS16435 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEC75_RS16450 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEC75_RS16455 ENOG4108V1U phospholipid-binding protein HEC75_RS16485 ENOG4105NBR Pectinesterase HEC75_RS16495 ENOG4108K4B hydrolase HEC75_RS16505 ENOG4105E0C molybdate abc transporter HEC75_RS16510 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HEC75_RS16520 ENOG4105F4R Transcriptional regulator mode HEC75_RS16525 ENOG4105DKW ABC transporter HEC75_RS16535 ENOG4105CMR udp-glucose 4-epimerase HEC75_RS16540 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HEC75_RS16550 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEC75_RS16560 ENOG4105E0A ABC, transporter HEC75_RS16565 ENOG4105EHG Permease protein HEC75_RS16570 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HEC75_RS16575 ENOG4105D9Q decarboxylase (Beta subunit) HEC75_RS16580 ENOG4107QSA Oxaloacetate decarboxylase HEC75_RS16585 ENOG4106AFN Lyase and sodium transporter (By similarity) HEC75_RS16590 ENOG4107QWE )-transporter HEC75_RS16600 ENOG4105C5Q Transcriptional regulator HEC75_RS16610 ENOG4107GFK fumarate HEC75_RS16615 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC75_RS16620 ENOG4105JND homeobox protein HEC75_RS16625 ENOG4105PGM cation diffusion facilitator family transporter HEC75_RS16630 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HEC75_RS16670 ENOG4105UFD tol-pal system protein YbgF HEC75_RS16675 ENOG4105KCK Peptidoglycan-associated lipoprotein HEC75_RS16685 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HEC75_RS16695 ENOG4105E02 MotA TolQ exbB proton channel HEC75_RS16700 ENOG4107YD3 Thioesterase HEC75_RS16705 ENOG4105KJB cyd operon protein YbgE HEC75_RS16715 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEC75_RS16720 ENOG4105C4M (Ubiquinol oxidase) subunit I HEC75_RS16725 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HEC75_RS16735 ENOG4105C7S Dehydrogenase HEC75_RS16740 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEC75_RS16745 ENOG4105E33 succinate dehydrogenase HEC75_RS16750 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEC75_RS16755 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HEC75_RS16760 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HEC75_RS16770 ENOG4105BZN citrate synthase HEC75_RS16775 ENOG4108KK1 membrane protein AbrB duplication HEC75_RS16790 ENOG4107R7A Allophanate hydrolase subunit 2 HEC75_RS16795 ENOG4105P4J Allophanate hydrolase, subunit 1 HEC75_RS16800 ENOG4107QNR UPF0135 protein HEC75_RS16810 ENOG4105CVP deoxyribo-dipyrimidine photolyase HEC75_RS16815 ENOG4105XIQ Protein of unknown function (DUF2517) HEC75_RS16840 ENOG4105C08 Histidine kinase HEC75_RS16845 ENOG4105EEX Two component transcriptional regulator (Winged helix family HEC75_RS16855 ENOG4105CXN decarboxylase HEC75_RS16860 ENOG4105D5Q Arginine ornithine antiporter HEC75_RS16870 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HEC75_RS16875 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HEC75_RS16880 ENOG4105EV9 Alpha Beta Hydrolase HEC75_RS16885 ENOG4105NNH LexA regulated protein HEC75_RS16890 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HEC75_RS16895 ENOG41090R7 Ferric uptake HEC75_RS16900 ENOG4106P55 Transcriptional regulator HEC75_RS16905 ENOG4107EFR Flavocytochrome c HEC75_RS16910 ENOG41079YP Citrate utilization protein b HEC75_RS16915 ENOG4105CSH Transporter HEC75_RS16920 ENOG4105GX6 (LipO)protein HEC75_RS16925 ENOG4105J5J Outer membrane porin HEC75_RS16935 ENOG4105CI1 PTS System HEC75_RS16945 ENOG4105CE4 GlcNAc 6-P deacetylase HEC75_RS16950 ENOG4105E2R ROK family HEC75_RS16955 ENOG4105D4U had-superfamily hydrolase, subfamily iia HEC75_RS16960 ENOG4105CAQ asparagine synthetase HEC75_RS17000 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HEC75_RS17010 ENOG4105C9A Phoh family HEC75_RS17020 ENOG4108JU5 Magnesium and cobalt efflux protein HEC75_RS17025 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HEC75_RS17030 ENOG4107RP9 extracellular solute-binding protein, family 3 HEC75_RS17035 ENOG4105EAD ABC transporter HEC75_RS17040 ENOG4105DRP amino acid AbC transporter HEC75_RS17045 ENOG4105CDA abc transporter atp-binding protein HEC75_RS17060 ENOG4107PAI alpha helical protein HEC75_RS17065 ENOG4108JUB Transcriptional regulator HEC75_RS17070 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HEC75_RS17095 ENOG4105DJF DNA polymerase III, delta' subunit HEC75_RS17100 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HEC75_RS17105 ENOG4107QZB decarboxylase HEC75_RS17110 ENOG4108TGR phosphatase HEC75_RS17115 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HEC75_RS17120 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HEC75_RS17125 ENOG4105CJN penicillin-binding protein HEC75_RS17130 ENOG4105CNI cell division protein FtsW HEC75_RS17135 ENOG4105K6T rare lipoprotein A HEC75_RS17140 ENOG4105DZ1 carboxypeptidase HEC75_RS17145 ENOG4108Z43 UPF0250 protein HEC75_RS17155 ENOG41064T2 transcriptional regulator, lysR family HEC75_RS17175 ENOG4107Z6W Protein CrcB homolog HEC75_RS17190 ENOG4105CEE C4-dicarboxylate transporter HEC75_RS17195 ENOG4106YYS transcriptional regulatory protein HEC75_RS17205 ENOG4105DUA (citrate (pro-3S)-lyase ligase HEC75_RS17210 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HEC75_RS17215 ENOG4105CI0 Citrate lyase HEC75_RS17220 ENOG4105CHY citrate lyase, alpha HEC75_RS17225 ENOG4105YGP holo-ACP synthase CitX HEC75_RS17235 ENOG4107QPK )-transporter HEC75_RS17240 ENOG4105KTS ribonuclease HEC75_RS17245 ENOG4105NXH GreA GreB family elongation factor HEC75_RS17250 ENOG4105E2A Dehydrogenase HEC75_RS17255 ENOG4108U51 Universal stress protein HEC75_RS17265 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC75_RS17270 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEC75_RS17280 ENOG4108JU3 Alkyl hydroperoxide reductase HEC75_RS17285 ENOG4105D3R alkyl hydroperoxide reductase HEC75_RS17290 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HEC75_RS17295 ENOG4105DQS Transcriptional regulator HEC75_RS17300 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HEC75_RS17305 ENOG4105GTN ParB Domain Protein Nuclease HEC75_RS17310 ENOG4105CHM Aminotransferase HEC75_RS17315 ENOG4107SCQ Iron-containing alcohol dehydrogenase HEC75_RS17320 ENOG4105VCD cytoplasmic protein HEC75_RS17325 ENOG4105D22 carbon starvation protein HEC75_RS17335 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HEC75_RS17340 ENOG4105WQI isochorismatase HEC75_RS17345 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HEC75_RS17350 ENOG4105E4F Isochorismate synthase HEC75_RS17355 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HEC75_RS17360 ENOG4105E8G Major facilitator Superfamily HEC75_RS17365 ENOG4105DQ5 transport system permease protein HEC75_RS17370 ENOG4105TVJ transport system, permease HEC75_RS17375 ENOG4105E0A ABC, transporter HEC75_RS17380 ENOG4108QY5 Ferric enterobactin transport protein HEC75_RS17385 ENOG4105C0W non-ribosomal peptide synthetase HEC75_RS17390 ENOG41085A6 mbth domain-containing protein HEC75_RS17395 ENOG4105E93 esterase HEC75_RS17400 ENOG4107RNH Outer membrane receptor FepA HEC75_RS17405 ENOG4108TSE Transferase HEC75_RS17415 ENOG4105WQ6 Membrane HEC75_RS17420 ENOG4105HFT AraC family transcriptional regulator HEC75_RS17425 ENOG41067SE Tetr family transcriptional regulator HEC75_RS17430 ENOG4105MSB protein, conserved in bacteria HEC75_RS17435 ENOG4108RCM Nitroreductase HEC75_RS17445 ENOG4105CUY Mechanosensitive ion channel HEC75_RS17450 ENOG4105C85 amino acid HEC75_RS17460 ENOG4108KBJ Inner membrane protein YkgB HEC75_RS17465 ENOG41066GK UPF0379 protein ykgI HEC75_RS17470 ENOG4107QN2 dihydrolipoyl dehydrogenase HEC75_RS17475 ENOG4108K01 transcriptional regulator HEC75_RS17495 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HEC75_RS17500 ENOG4105CKK Glycosyl transferase, family 2 HEC75_RS17525 ENOG4106KCD HTH_LUXR HEC75_RS17535 ENOG4106721 fimbriae Y protein HEC75_RS17540 ENOG4108Q9V regulatoR HEC75_RS17545 ENOG4108ZI2 Fimbrial protein HEC75_RS17550 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HEC75_RS17555 ENOG4105CW0 outer membrane usher protein HEC75_RS17560 ENOG4108AF8 Chaperone HEC75_RS17570 ENOG4108WDE Fimbrial protein HEC75_RS17580 ENOG4105WQ3 Rna-binding protein HEC75_RS17585 ENOG4105S2T inner membrane protein YbcI HEC75_RS17605 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HEC75_RS17615 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HEC75_RS17620 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HEC75_RS17625 ENOG4105C5B carbamate kinase HEC75_RS17630 ENOG4105G5A Protein of unknown function (DUF2877) HEC75_RS17635 ENOG4107REC cytoplasmic protein HEC75_RS17640 ENOG4107R1Q Membrane protein FdrA HEC75_RS17645 ENOG4105DG4 malate L-lactate dehydrogenase HEC75_RS17650 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HEC75_RS17655 ENOG4105S0E allantoin catabolism protein HEC75_RS17660 ENOG4105BZW Glycerate kinase HEC75_RS17665 ENOG4105DTE Xanthine uracil vitamin C permease HEC75_RS17675 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HEC75_RS17685 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEC75_RS17690 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HEC75_RS17695 ENOG41060W2 glyoxylate carboligase HEC75_RS17720 ENOG4108UMI ABC transporter, permease HEC75_RS17725 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEC75_RS17730 ENOG4105D01 (LipO)protein HEC75_RS17740 ENOG4105CV6 ABC transporter, permease HEC75_RS17745 ENOG4108I0Y (ABC) transporter HEC75_RS17750 ENOG4108UJV acyl-CoA thioesterase i HEC75_RS17755 ENOG4105E1F short-chain dehydrogenase reductase HEC75_RS17760 ENOG4107QR8 Thioredoxin HEC75_RS17765 ENOG4105C4B ABC transporter, permease HEC75_RS17770 ENOG41083J0 (ABC) transporter HEC75_RS17775 ENOG4107QX8 SPFH domain, Band 7 family protein HEC75_RS17780 ENOG4105G5H Membrane HEC75_RS17785 ENOG4108Z6Z Transcriptional regulator HEC75_RS17790 ENOG4105C59 p-type ATPase HEC75_RS17800 ENOG4105MBR gumn family HEC75_RS17805 ENOG4108Z66 YbaK ebsC protein HEC75_RS17810 ENOG4105CGH 5'-nucleotidase HEC75_RS17815 ENOG4105EU0 Major facilitator Superfamily HEC75_RS17820 ENOG4105CKD glutathione-regulated potassium-efflux system protein HEC75_RS17825 ENOG4107RE1 Inosine-guanosine kinase HEC75_RS17860 ENOG4107QMP dna polymerase iii subunits gamma and tau HEC75_RS17870 ENOG4105WD1 Membrane HEC75_RS17875 ENOG4108URS primosomal replication protein n'' HEC75_RS17880 ENOG4106428 Protein of unknown function (DUF2496) HEC75_RS17885 ENOG4105DNE Transposase HEC75_RS17890 ENOG4105EGS Mechanosensitive ion channel HEC75_RS17895 ENOG4107XI7 Tetr family transcriptional regulator HEC75_RS17900 ENOG4105C1P efflux transporter, rnd family, mfp subunit HEC75_RS17905 ENOG4105BZS acriflavin resistance protein HEC75_RS17910 ENOG4108UKR Biofilm formation regulator YbaJ HEC75_RS17920 ENOG4108UW5 maltose o-acetyltransferase HEC75_RS17925 ENOG4105GSJ Inner membrane protein ylaC HEC75_RS17940 ENOG41066DG (EAL) domain protein HEC75_RS17950 ENOG41080UX Methyltransferase HEC75_RS17955 ENOG4108MNP Glycoprotein polysaccharide metabolism HEC75_RS17960 ENOG4105C29 acyl-CoA thioesterase HEC75_RS17965 ENOG4105BZU Histidine kinase HEC75_RS17970 ENOG4108YZA Nitrogen regulatory protein pii HEC75_RS17975 ENOG4105BZ1 (ABC) transporter HEC75_RS17980 ENOG4105BZ1 (ABC) transporter HEC75_RS17985 ENOG4108XM1 transcriptional regulator AsnC family HEC75_RS18000 ENOG4108NFA extracellular solute-binding protein HEC75_RS18010 ENOG4108TGP Thioesterase superfamily protein HEC75_RS18015 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HEC75_RS18020 ENOG4105EIN peptidylprolyl cis-trans isomerase HEC75_RS18025 ENOG4105K70 DNA-binding protein HEC75_RS18030 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HEC75_RS18050 ENOG4105M85 Bola protein HEC75_RS18055 ENOG4105IEY (LipO)protein HEC75_RS18060 ENOG4105EYM Major Facilitator superfamily HEC75_RS18065 ENOG4105E2S oxidase) subunit II HEC75_RS18070 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEC75_RS18075 ENOG4105CCU oxidase (Subunit III) HEC75_RS18080 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HEC75_RS18100 ENOG4107RDB Major Facilitator HEC75_RS18110 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEC75_RS18115 ENOG4107S0N DJ-1 family HEC75_RS18130 ENOG4106S9K Transcriptional regulator HEC75_RS18140 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEC75_RS18145 ENOG4108MP3 ABC transporter, permease HEC75_RS18150 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HEC75_RS18160 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEC75_RS18165 ENOG4105CTB Polyprenyl synthetase HEC75_RS18175 ENOG4105CPC Aldo Keto reductase HEC75_RS18180 ENOG4108ZAI phosphatidylglycerophosphatase a HEC75_RS18185 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HEC75_RS18190 ENOG4107YIM Involved in the transcription termination process (By similarity) HEC75_RS18200 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HEC75_RS18210 ENOG4108KIC (LipO)protein HEC75_RS18215 ENOG4105DRB nucleoside-specific channel-forming protein HEC75_RS18225 ENOG4105N1F Hnh endonuclease HEC75_RS18240 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEC75_RS18250 ENOG4105VIE preprotein translocase, subunit YajC HEC75_RS18270 ENOG4105D3R alkyl hydroperoxide reductase HEC75_RS18280 ENOG4107R28 alpha amylase, catalytic region HEC75_RS18285 ENOG4105C85 amino acid HEC75_RS18290 ENOG4105CWM branched-chain amino acid transport system II carrier protein HEC75_RS18295 ENOG4105BZU Histidine kinase HEC75_RS18300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEC75_RS18305 ENOG4107RH8 nuclease SbcCD subunit D HEC75_RS18310 ENOG4105EYH Exonuclease HEC75_RS18315 ENOG4105F27 Major Facilitator HEC75_RS18320 ENOG4105DKQ ROK family HEC75_RS18335 ENOG4105HBA AroM protein HEC75_RS18340 ENOG4105SS3 HEC75_RS18355 ENOG4105II7 pyrroline-5-carboxylate reductase HEC75_RS18360 ENOG4105BZU Histidine kinase HEC75_RS18365 ENOG4105VIF phosphate starvation-inducible protein HEC75_RS18385 ENOG4105CPF Cell wall formation (By similarity) HEC75_RS18390 ENOG4105UNH Membrane HEC75_RS18395 ENOG4105FR5 inner membrane protein YaiY HEC75_RS18400 ENOG4107QS8 (LipO)protein HEC75_RS18405 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HEC75_RS18410 ENOG4107R6D beta-lactam binding protein AmpH HEC75_RS18415 ENOG4108PNB DNA-binding transcriptional regulator HEC75_RS18420 ENOG4108NSE outer membrane autotransporter barrel HEC75_RS18425 ENOG4105D52 delta-aminolevulinic acid dehydratase HEC75_RS18430 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEC75_RS18435 ENOG4105DXD 2-methylcitrate dehydratase HEC75_RS18440 ENOG4105BZN citrate synthase HEC75_RS18445 ENOG4105CR4 methylisocitrate lyase HEC75_RS18450 ENOG4108JU7 Transcriptional regulator HEC75_RS18455 ENOG4105TDT uncharacterized protein yahO HEC75_RS18460 ENOG4105E82 cytochrome subunit of dehydrogenase HEC75_RS18480 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEC75_RS18485 ENOG4105C4M (Ubiquinol oxidase) subunit I HEC75_RS18495 ENOG4105D8D Type III HEC75_RS18500 ENOG4107QMH DNA methylase HEC75_RS18505 ENOG4105JHE Major Facilitator Superfamily HEC75_RS18535 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HEC75_RS18555 ENOG4108T1M outer membrane protein x HEC75_RS18570 ENOG4107XTP (EAL) domain protein HEC75_RS18585 ENOG4105X0I Fimbrial HEC75_RS18590 ENOG4108VEV chaperone HEC75_RS18595 ENOG4105CW0 outer membrane usher protein HEC75_RS18615 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HEC75_RS18620 ENOG4105CKK Glycosyl transferase, family 2 HEC75_RS18730 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HEC75_RS18735 ENOG4105KUS lysozyme HEC75_RS18745 ENOG4105HGD Antitermination protein HEC75_RS18790 ENOG4105NY2 NinB protein HEC75_RS18800 ENOG4105CDU Replicative dna helicase HEC75_RS18885 ENOG4105VIZ double-strand break repair protein HEC75_RS18905 ENOG41077V0 CPS-53 (KpLE1) prophage HEC75_RS18940 ENOG4108KU3 Integrase HEC75_RS18960 ENOG4105FCK Membrane HEC75_RS18975 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HEC75_RS18980 ENOG4105CIN aminoacyl-histidine dipeptidase HEC75_RS18985 ENOG4108S2Y peptide Chain Release factor HEC75_RS19000 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HEC75_RS19005 ENOG4105E7A Glutamine amidotransferase HEC75_RS19020 ENOG4107QPN acyl-Coa dehydrogenase HEC75_RS19025 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HEC75_RS19035 ENOG4105T40 surface antigen msp4 family protein HEC75_RS19055 ENOG4108XM1 transcriptional regulator AsnC family HEC75_RS19095 ENOG4105W7K Transcriptional regulator HEC75_RS19180 ENOG4105CS6 Rhs element vgr protein HEC75_RS19280 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC75_RS19320 ENOG4107RZZ dna polymerase iii epsilon subunit HEC75_RS19325 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HEC75_RS19330 ENOG4105D1A Methyltransferase HEC75_RS19340 ENOG4105E9H Lytic Murein transglycosylase HEC75_RS19345 ENOG4105F2W methyltransferase HEC75_RS19355 ENOG4105F27 Major Facilitator HEC75_RS19360 ENOG4105HEI LysR family (Transcriptional regulator HEC75_RS19365 ENOG4105CV8 reductase HEC75_RS19400 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HEC75_RS19405 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEC75_RS19410 ENOG4108UMI ABC transporter, permease HEC75_RS19415 ENOG4105D01 (LipO)protein HEC75_RS19420 ENOG4108R8X outer membrane lipoprotein HEC75_RS19425 ENOG4108R96 Methyltransferase, YaeB family HEC75_RS19435 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HEC75_RS19440 ENOG4108YZN class I peptide chain release factor HEC75_RS19445 ENOG4108VWS Yaeq family HEC75_RS19455 ENOG4105M1T rho-binding antiterminator HEC75_RS19465 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HEC75_RS19470 ENOG4105CXN decarboxylase HEC75_RS19475 ENOG4108M1A Chitin-binding protein HEC75_RS19485 ENOG4105C0B DNA polymerase III (alpha subunit) HEC75_RS19505 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HEC75_RS19510 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HEC75_RS19515 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HEC75_RS19530 ENOG4105KNE Phosphatidate cytidylyltransferase HEC75_RS19545 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HEC75_RS19550 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HEC75_RS19560 ENOG4105CE9 30S ribosomal protein S2 HEC75_RS19565 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HEC75_RS19580 ENOG4105CSH Transporter HEC75_RS19590 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HEC75_RS19595 ENOG4105C0H protease HEC75_RS19610 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HEC75_RS19615 ENOG4105EN6 Membrane HEC75_RS19620 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HEC75_RS19635 ENOG4106RDH Protein of unknown function (DUF2544) HEC75_RS19645 ENOG4105UGQ Fimbrial HEC75_RS19650 ENOG4105NEV Fimbrial HEC75_RS19655 ENOG4108FZ9 Chaperone HEC75_RS19660 ENOG4106PG1 outer membrane usher protein HEC75_RS19675 ENOG4105S6R Iron-hydroxamate transporter permease subunit HEC75_RS19680 ENOG4105J76 Periplasmic binding protein HEC75_RS19685 ENOG4105E0A ABC, transporter HEC75_RS19690 ENOG4105E0K tonB-dependent siderophore receptor HEC75_RS19695 ENOG4105BZ4 penicillin-binding protein HEC75_RS19700 ENOG4105CQ7 ATP-dependent helicase HEC75_RS19705 ENOG4107XID 2'-5' rna ligase HEC75_RS19715 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HEC75_RS19720 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HEC75_RS19725 ENOG4105DJ0 Poly(A) Polymerase HEC75_RS19730 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HEC75_RS19755 ENOG4108VEV chaperone HEC75_RS19760 ENOG4105CW0 outer membrane usher protein HEC75_RS19765 ENOG4108XEY fimbrial-like adhesin protein HEC75_RS19785 ENOG4107BJW polysaccharide deacetylase HEC75_RS19790 ENOG4108YTN IIa component HEC75_RS19795 ENOG4105E3A (ABC) transporter HEC75_RS19800 ENOG4105DA5 (ABC) transporter HEC75_RS19805 ENOG41077A9 carbonic anhydrase HEC75_RS19810 ENOG4108UGV hypoxanthine phosphoribosyltransferase HEC75_RS19815 ENOG4105DZG Dehydrogenase HEC75_RS19820 ENOG4105E3B Multicopper oxidase HEC75_RS19825 ENOG4108ZRK uncharacterized protein yacC HEC75_RS19840 ENOG4105MVE transcriptional regulator HEC75_RS19845 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HEC75_RS19850 ENOG4107S2N Type III effector Hrp-dependent HEC75_RS19855 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HEC75_RS19865 ENOG4107QIJ Aconitate hydratase 2 HEC75_RS19870 ENOG4108NST exported protein HEC75_RS19885 ENOG4107QN2 dihydrolipoyl dehydrogenase HEC75_RS19890 ENOG4107QSN dihydrolipoamide acetyltransferase HEC75_RS19895 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEC75_RS19910 ENOG4105CT4 transporter HEC75_RS19915 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HEC75_RS19920 ENOG4106A72 regulatory protein AmpE HEC75_RS19930 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HEC75_RS19935 ENOG4108ZUW Major pilin subunit HEC75_RS19940 ENOG4107QHF type ii secretion system protein e HEC75_RS19945 ENOG4105D7Q type ii secretion system HEC75_RS19955 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HEC75_RS19965 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HEC75_RS19980 ENOG4105M6F mutator MutT protein HEC75_RS20000 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HEC75_RS20005 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HEC75_RS20010 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HEC75_RS20030 ENOG4105CNI cell division protein FtsW HEC75_RS20040 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HEC75_RS20045 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HEC75_RS20055 ENOG4105CJN penicillin-binding protein HEC75_RS20060 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HEC75_RS20075 ENOG4107B7Y DNA-binding transcriptional regulator FruR HEC75_RS20080 ENOG4108ZP8 Acetolactate synthase small subunit HEC75_RS20085 ENOG4105C7K acetolactate synthase HEC75_RS20090 ENOG41064T2 transcriptional regulator, lysR family HEC75_RS20110 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEC75_RS20150 ENOG4108KF1 Membrane HEC75_RS20155 ENOG41063TF transcriptional regulator (AraC HEC75_RS20170 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HEC75_RS20190 ENOG4105CQ2 DNA polymerase HEC75_RS20200 ENOG4105D3G Pseudouridine synthase HEC75_RS20210 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HEC75_RS20220 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HEC75_RS20230 ENOG4105NWN ApaG protein HEC75_RS20270 ENOG4105M5B (LipO)protein HEC75_RS20275 ENOG4105C54 Major Facilitator superfamily HEC75_RS20280 ENOG4105WQV ferredoxin-like protein HEC75_RS20285 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HEC75_RS20330 ENOG4108XNW Transcriptional activatory protein CaiF HEC75_RS20335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HEC75_RS20340 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HEC75_RS20365 ENOG4105CHY citrate lyase, alpha HEC75_RS20370 ENOG4105CI0 Citrate lyase HEC75_RS20380 ENOG4105DUA (citrate (pro-3S)-lyase ligase HEC75_RS20395 ENOG4107QSA Oxaloacetate decarboxylase HEC75_RS20400 ENOG4105D9Q decarboxylase (Beta subunit) HEC75_RS20405 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEC75_RS20410 ENOG4106YYS transcriptional regulatory protein HEC75_RS20430 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HEC75_RS20445 ENOG4105DTN riboflavin biosynthesis protein ribF HEC75_RS20450 ENOG410647N response to DNA damage stimulus HEC75_RS20470 ENOG41063Z6 transcriptional regulator, lysR family HEC75_RS20490 ENOG4105C4X radical SAM domain protein HEC75_RS20495 ENOG41061MV Arylsulfatase HEC75_RS20505 ENOG4105CGH 5'-nucleotidase HEC75_RS20540 ENOG4106PH7 chaperone HEC75_RS20555 ENOG4105MHR Fimbrial protein HEC75_RS20560 ENOG4105CW0 outer membrane usher protein HEC75_RS20565 ENOG4108AF8 Chaperone HEC75_RS20570 ENOG4108RQP Major type 1 subunit fimbrin HEC75_RS20620 ENOG4108WTA UPF0412 protein YaaI HEC75_RS20625 ENOG4108QUJ UPF0174 protein YaaW HEC75_RS20630 ENOG4106HK8 GPR1 FUN34 yaaH family protein HEC75_RS20635 ENOG4108RIR Molybdenum cofactor biosynthesis protein HEC75_RS20640 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEC75_RS20645 ENOG4105BZG amino acid carrier protein HEC75_RS20655 ENOG4105D98 threonine synthase HEC75_RS20665 ENOG4105CFH Aspartokinase HEC75_RS20675 ENOG4106FVC RNA methyltransferase HEC75_RS20680 ENOG410759A HEC75_RS20685 ENOG41065U4 response regulator HEC75_RS20695 ENOG4108PNB DNA-binding transcriptional regulator HEC75_RS20705 ENOG4108VCD Chaperone HEC75_RS20710 ENOG4105CW0 outer membrane usher protein HEC75_RS20725 ENOG4105CT7 inner membrane cred family protein HEC75_RS20730 ENOG4105EB3 Histidine kinase HEC75_RS20735 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC75_RS20740 ENOG4108RH0 Crea protein HEC75_RS20745 ENOG4105UEI Transcriptional Regulator AraC Family HEC75_RS20765 ENOG4107SC1 transglycosylase HEC75_RS20770 ENOG4105C5H ABC transporter HEC75_RS20775 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HEC75_RS20780 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HEC75_RS20785 ENOG4105EAC phosphoserine phosphatase HEC75_RS20790 ENOG41062Z9 Membrane HEC75_RS20825 ENOG4105G0K glycine radical enzyme YjjI family HEC75_RS20830 ENOG41076CZ activating enzyme HEC75_RS20835 ENOG4105EYA deoxyribonuclease HEC75_RS20840 ENOG4108NRW Phospholipase, patatin family HEC75_RS20850 ENOG4105K3G Periplasmic Protein HEC75_RS20860 ENOG4105PAD Hydrolase HEC75_RS20865 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HEC75_RS20870 ENOG4108WPU DNA polymerase III subunit psi HEC75_RS20895 ENOG4105YBH Protein of unknown function (DUF1435) HEC75_RS20900 ENOG4105BZU Histidine kinase HEC75_RS20905 ENOG4108819 ferric iron reductase HEC75_RS20910 ENOG4108UIN ybak prolyl-trna synthetase associated region HEC75_RS20915 ENOG4108T94 DNA-binding transcriptional activator BglJ HEC75_RS20920 ENOG4108N8T regulatoR HEC75_RS20925 ENOG4105DWK Membrane HEC75_RS20940 ENOG4106CVF DNA replication protein HEC75_RS20945 ENOG4105RI1 glycoprotein receptor HEC75_RS20955 ENOG4105C8Q Methyl-accepting chemotaxis HEC75_RS20960 ENOG4105D22 carbon starvation protein HEC75_RS20965 ENOG4105VCD cytoplasmic protein HEC75_RS20970 ENOG4105CKI cobalamin synthesis protein HEC75_RS20975 ENOG41063TF transcriptional regulator (AraC HEC75_RS20980 ENOG4105E82 cytochrome subunit of dehydrogenase HEC75_RS20985 ENOG4108HFV HEC75_RS21000 ENOG4105C26 Dehydrogenase HEC75_RS21005 ENOG4105DNE Transposase HEC75_RS21010 ENOG41083G8 Multidrug resistance protein MdtM HEC75_RS21015 ENOG4106BRA Membrane HEC75_RS21020 ENOG4105CBP Major Facilitator HEC75_RS21025 ENOG41074DU domain protein HEC75_RS21030 ENOG4108P2H Inner membrane protein YjiG HEC75_RS21035 ENOG4105DYB Isoaspartyl dipeptidase HEC75_RS21040 ENOG4107YNJ LysR family Transcriptional regulator HEC75_RS21060 ENOG4105C6F GntR Family Transcriptional Regulator HEC75_RS21080 ENOG4105KZM cytoplasmic protein HEC75_RS21090 ENOG4105DTA methyltransferase HEC75_RS21140 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC75_RS21160 ENOG4105C0D helicase HEC75_RS21175 ENOG4107QMH DNA methylase HEC75_RS21195 ENOG4105DQ4 alcohol dehydrogenase HEC75_RS21200 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEC75_RS21205 ENOG4105CPQ Dehydrogenase HEC75_RS21210 ENOG4105CHR reductase HEC75_RS21215 ENOG4105C6Z Gluconate HEC75_RS21220 ENOG4105K2J Transcriptional regulator HEC75_RS21225 ENOG4108K5H permease YjgP YjgQ family protein HEC75_RS21230 ENOG4108M8S permease YjgP YjgQ family protein HEC75_RS21240 ENOG4105MYG DNA polymerase iii, chi subunit HEC75_RS21245 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HEC75_RS21250 ENOG4108M3P Membrane HEC75_RS21255 ENOG4108MJ3 acetyltransferase HEC75_RS21270 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HEC75_RS21275 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HEC75_RS21280 ENOG4105DBV ornithine carbamoyltransferase HEC75_RS21285 ENOG4105XEP YhcH YjgK YiaL family protein HEC75_RS21290 ENOG4105CEU Arginine dihydrolase HEC75_RS21295 ENOG4105C5B carbamate kinase HEC75_RS21300 ENOG4105DBV ornithine carbamoyltransferase HEC75_RS21305 ENOG4105CSX c4-dicarboxylate anaerobic carrier HEC75_RS21310 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HEC75_RS21320 ENOG41077AM PyrBI operon attenuator HEC75_RS21335 ENOG4105KME endoribonuclease L-psp HEC75_RS21350 ENOG4105D4X repressor HEC75_RS21355 ENOG4105C5Y PTS System HEC75_RS21360 ENOG4105CG3 alpha amylase, catalytic region HEC75_RS21365 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HEC75_RS21370 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HEC75_RS21375 ENOG4105K4U addiction module toxin, RelE StbE family HEC75_RS21385 ENOG4105EMD TRANSCRIPTIONal HEC75_RS21400 ENOG41069H0 dihydroorotase EC 3.5.2.3 HEC75_RS21430 ENOG4108XVM Cytochrome b(562) HEC75_RS21435 ENOG4105CMS peptidase U62, modulator of DNA gyrase HEC75_RS21445 ENOG4105F0H myo-inositol catabolism protein HEC75_RS21455 ENOG4105IE8 Alpha-ketoglutarate permease HEC75_RS21460 ENOG4105CK5 oxidoreductase HEC75_RS21465 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEC75_RS21470 ENOG4105D7K pfkb domain protein HEC75_RS21480 ENOG4107VG4 Xylose isomerase domain protein TIM barrel HEC75_RS21485 ENOG4108MYR Secreted protein HEC75_RS21510 ENOG4105C26 Dehydrogenase HEC75_RS21515 ENOG4105DH8 myo-inositol catabolism HEC75_RS21520 ENOG4107QNK )-transporter HEC75_RS21525 ENOG4107QNK )-transporter HEC75_RS21530 ENOG4105CHC glucokinase (EC 2.7.1.2) HEC75_RS21535 ENOG4105DFU Cell wall formation (By similarity) HEC75_RS21545 ENOG4105F0N pyrophosphate phospho-hydrolase HEC75_RS21550 ENOG41069H0 dihydroorotase EC 3.5.2.3 HEC75_RS21555 ENOG4105DJB Major Facilitator Superfamily HEC75_RS21560 ENOG4108ZHD aig2 family HEC75_RS21580 ENOG4105C37 (CBS) domain HEC75_RS21585 ENOG41061GZ Protein of unknown function (DUF1107) HEC75_RS21590 ENOG4108UUE Transcriptional regulator HEC75_RS21595 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HEC75_RS21600 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HEC75_RS21605 ENOG4105KVH Transcriptional regulator HEC75_RS21610 ENOG4105ECR NmrA family HEC75_RS21615 ENOG4105DXC membrane HEC75_RS21630 ENOG4108V1T peptidylprolyl cis-trans isomerase HEC75_RS21635 ENOG4105FHY Opacity-associated protein A HEC75_RS21645 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HEC75_RS21650 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEC75_RS21655 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HEC75_RS21660 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HEC75_RS21670 ENOG4105KIT UPF0379 protein yjfY HEC75_RS21700 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HEC75_RS21715 ENOG4108MXZ Esterase HEC75_RS21720 ENOG4105WSB biofilm stress and motility protein A HEC75_RS21725 ENOG4105S17 UPF0379 protein yjfN HEC75_RS21730 ENOG4105CSU acyl-Coa dehydrogenase HEC75_RS21735 ENOG4106032 Glutathionylspermidine synthase HEC75_RS21740 ENOG4108KXT Conserved Protein HEC75_RS21745 ENOG4105Z6B inner membrane protein yjfl HEC75_RS21750 ENOG4107VNS Protein of unknown function (DUF2491) HEC75_RS21755 ENOG4108P9J Phage shock protein A HEC75_RS21760 ENOG4105FUX Conserved Protein HEC75_RS21765 ENOG4105C2N RNA methyltransferase TrmH family group 3 HEC75_RS21770 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HEC75_RS21790 ENOG4105EPW hflc protein HEC75_RS21795 ENOG4107QJR hflk protein HEC75_RS21800 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HEC75_RS21805 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HEC75_RS21820 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HEC75_RS21825 ENOG4105K8N protein family UPF0079, ATPase HEC75_RS21830 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HEC75_RS21835 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HEC75_RS21850 ENOG4106TNF Periplasmic binding protein HEC75_RS21855 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HEC75_RS21870 ENOG4105EGS Mechanosensitive ion channel HEC75_RS21875 ENOG4106CG8 Inner membrane protein YjeO HEC75_RS21880 ENOG4107SC7 Inner membrane transporter yjeM HEC75_RS21890 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEC75_RS21895 ENOG4105E33 succinate dehydrogenase HEC75_RS21905 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HEC75_RS21915 ENOG4105KPY Small multidrug resistance protein HEC75_RS21925 ENOG4106BSU Entericidin B HEC75_RS21935 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HEC75_RS21940 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HEC75_RS21945 ENOG4105MTB Uncharacterized protein YjeJ HEC75_RS21950 ENOG4108ZVF (LipO)protein HEC75_RS21965 ENOG4105DVH amino acid HEC75_RS21970 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HEC75_RS21975 ENOG4108IJ0 Aspartate ammonia-lyase HEC75_RS21980 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HEC75_RS21995 ENOG4108SIC Transcriptional regulator HEC75_RS22010 ENOG4105SBG acid phosphatase HEC75_RS22040 ENOG41068CG regulatoR HEC75_RS22055 ENOG4108ZK4 sdia-regulated domain-containing protein HEC75_RS22065 ENOG4108NEM leader-binding protein dmsD HEC75_RS22070 ENOG4107KGK dmso reductase anchor subunit HEC75_RS22075 ENOG4105QAX Iron-sulfur HEC75_RS22080 ENOG4107QY8 reductase HEC75_RS22085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEC75_RS22090 ENOG4108MRH transcriptional regulatory protein HEC75_RS22100 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HEC75_RS22105 ENOG4107GFK fumarate HEC75_RS22110 ENOG4105CT4 transporter HEC75_RS22115 ENOG4105F8D glycoside hydrolase family 4 HEC75_RS22120 ENOG4108K2B transcriptional regulator HEC75_RS22125 ENOG4105CXN decarboxylase HEC75_RS22130 ENOG4106ZGR Transcriptional regulator HEC75_RS22135 ENOG4105D5Q Arginine ornithine antiporter HEC75_RS22140 ENOG4105DIJ Phosphoethanolamine transferase HEC75_RS22145 ENOG4105XJC Two component transcriptional regulator (Winged helix family HEC75_RS22150 ENOG4105ECM Sensor protein basS pmrB HEC75_RS22160 ENOG4105CSH Transporter HEC75_RS22165 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HEC75_RS22170 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HEC75_RS22175 ENOG410870W N-acetyltransferase HEC75_RS22190 ENOG41082ND Uncharacterized protein yjcO HEC75_RS22200 ENOG4105CK2 sodium dicarboxylate symporter HEC75_RS22205 ENOG4108W0S formate-dependent nitrite reductase complex HEC75_RS22215 ENOG4108QKW cytochrome c-type biogenesis protein HEC75_RS22220 ENOG4105DVI reductase, NrfD HEC75_RS22225 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC75_RS22230 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HEC75_RS22240 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEC75_RS22245 ENOG41062QD Membrane HEC75_RS22255 ENOG41067MG lrgb family HEC75_RS22265 ENOG4105CMU LysR family (Transcriptional regulator HEC75_RS22270 ENOG4105EEQ Na H antiporter HEC75_RS22275 ENOG4105C7N Xanthine uracil vitamin C permease HEC75_RS22285 ENOG4108Z4X TRANSCRIPTIONal HEC75_RS22290 ENOG4108W3Q Transcriptional regulator HEC75_RS22295 ENOG4108M8H domain protein HEC75_RS22300 ENOG4105PMV Membrane HEC75_RS22335 ENOG4108UUM single-stranded DNA-binding protein HEC75_RS22340 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEC75_RS22355 ENOG4105MSB protein, conserved in bacteria HEC75_RS22360 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HEC75_RS22365 ENOG4105F0S class B acid phosphatase HEC75_RS22370 ENOG4105CGF Aromatic amino acid aminotransferase HEC75_RS22375 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEC75_RS22380 ENOG4105CDU Replicative dna helicase HEC75_RS22385 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEC75_RS22390 ENOG4105P4Z Phage shock protein G HEC75_RS22395 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HEC75_RS22405 ENOG4105MYN Zinc uptake regulation protein HEC75_RS22410 ENOG4105VDW Csbd family HEC75_RS22420 ENOG4107R73 Mate efflux family protein HEC75_RS22425 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEC75_RS22430 ENOG41080IJ Diacylglycerol kinase HEC75_RS22450 ENOG4107W52 maltose operon periplasmic protein HEC75_RS22460 ENOG4108IJ9 (ABC) transporter HEC75_RS22465 ENOG4107FKK extracellular solute-binding protein family 1 HEC75_RS22470 ENOG4105D56 permease protein HEC75_RS22475 ENOG4105EG2 ABC transporter, permease HEC75_RS22485 ENOG4105E3R (LipO)protein HEC75_RS22490 ENOG4108Q9C Periplasmic Protein HEC75_RS22495 ENOG4108MDC (LipO)protein HEC75_RS22510 ENOG4105CFH Aspartokinase HEC75_RS22525 ENOG410667J hydrolase HEC75_RS22530 ENOG4105E98 transcriptional regulator DeoR family HEC75_RS22535 ENOG4108ZR5 Conserved Protein HEC75_RS22540 ENOG4105FE9 pseudouridine synthase HEC75_RS22545 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HEC75_RS22560 ENOG4105EAM Na Pi-cotransporter HEC75_RS22565 ENOG4105C3R Methionine synthase HEC75_RS22570 ENOG41069M3 Transcriptional regulator HEC75_RS22585 ENOG4108I9X Isocitrate lyase HEC75_RS22590 ENOG4107QP3 malate synthase g HEC75_RS22600 ENOG4105K5X acetyltransferase HEC75_RS22625 ENOG4105DC1 bifunctional purine biosynthesis protein purh HEC75_RS22630 ENOG4105C12 Phosphoribosylglycinamide synthetase HEC75_RS22635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC75_RS22640 ENOG4105BZU Histidine kinase HEC75_RS22650 ENOG4108T8B Protein of unknown function (DUF1481) HEC75_RS22655 ENOG4105K70 DNA-binding protein HEC75_RS22660 ENOG4105R2J Conserved Protein HEC75_RS22695 ENOG4105D06 uba thif-type nad fad binding protein HEC75_RS22700 ENOG4105WHD thiamine biosynthesis protein ThiS HEC75_RS22710 ENOG4105D41 biosynthesis protein thiH HEC75_RS22730 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEC75_RS22735 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEC75_RS22740 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEC75_RS22745 ENOG4108VZM 50s ribosomal protein L10 HEC75_RS22760 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HEC75_RS22765 ENOG4105PM1 preprotein translocase subunit SecE HEC75_RS22770 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEC75_RS22805 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HEC75_RS22810 ENOG4105D4A Cell wall formation (By similarity) HEC75_RS22855 ENOG4108Y73 Membrane HEC75_RS22870 ENOG4105C5Q Transcriptional regulator HEC75_RS22905 ENOG4105DIJ Phosphoethanolamine transferase HEC75_RS22910 ENOG4106R3P AraC family transcriptional regulator HEC75_RS22920 ENOG4105DCT glycerol dehydrogenase HEC75_RS22925 ENOG4108XC3 NADH ubiquinone oxidoreductase HEC75_RS22935 ENOG4105SYT Methylenetetrahydrofolate reductase HEC75_RS22945 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEC75_RS22950 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEC75_RS22955 ENOG4105CGH 5'-nucleotidase HEC75_RS22970 ENOG4105D64 Mechanosensitive ion channel HEC75_RS22975 ENOG4105CFH Aspartokinase HEC75_RS22980 ENOG4105C28 cystathionine HEC75_RS22990 ENOG4108MR7 Arylsulfotransferase HEC75_RS23005 ENOG4105C25 Primosomal protein n' HEC75_RS23010 ENOG4105ETE Transcriptional regulator (LacI family HEC75_RS23015 ENOG41063M6 Cell Division Protein HEC75_RS23030 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HEC75_RS23045 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEC75_RS23055 ENOG4105CBT Fructose-1,6-bisphosphatase HEC75_RS23060 ENOG4105DP0 ferredoxin-NADP reductase HEC75_RS23065 ENOG4108VTS Membrane HEC75_RS23070 ENOG4105EBK exported protein HEC75_RS23095 ENOG4105D7K pfkb domain protein HEC75_RS23100 ENOG4105CT4 transporter HEC75_RS23110 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HEC75_RS23115 ENOG4105CTQ phosphohexokinase HEC75_RS23125 ENOG4105FMW periplasmic HEC75_RS23130 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC75_RS23135 ENOG4105E0F Histidine kinase HEC75_RS23145 ENOG4108RPX mosc domain containing protein HEC75_RS23150 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEC75_RS23155 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HEC75_RS23160 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HEC75_RS23165 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HEC75_RS23170 ENOG4108QGT oligogalacturonate-specific porin HEC75_RS23195 ENOG4105DKG l-rhamnose isomerase HEC75_RS23205 ENOG4105C0A alcohol dehydrogenase HEC75_RS23220 ENOG4108UMN azlc family HEC75_RS23230 ENOG4108V87 frv operon regulatory protein HEC75_RS23235 ENOG4108V87 frv operon regulatory protein HEC75_RS23250 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC75_RS23255 ENOG4108MG3 formate dehydrogenase HEC75_RS23270 ENOG41068KX affects formate dehydrogenase-N HEC75_RS23280 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HEC75_RS23285 ENOG4108Z3N Transcriptional regulator HEC75_RS23290 ENOG4105SUU thioesterase domain HEC75_RS23305 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HEC75_RS23310 ENOG4105E98 transcriptional regulator DeoR family HEC75_RS23315 ENOG4108MGF sugar kinase HEC75_RS23320 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEC75_RS23325 ENOG4105D2M Aldolase HEC75_RS23330 ENOG4107QKS N-acylglucosamine 2-epimerase HEC75_RS23335 ENOG4107WI4 Aldose-1-epimerase HEC75_RS23340 ENOG4105CJQ hydrolase, family 31 HEC75_RS23345 ENOG4105CT4 transporter HEC75_RS23350 ENOG4105CT4 transporter HEC75_RS23355 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HEC75_RS23385 ENOG4108K4B hydrolase HEC75_RS23390 ENOG4105CI3 gtp-binding protein typa HEC75_RS23395 ENOG4105C5F glutamine synthetase HEC75_RS23400 ENOG4105CUX Signal transduction histidine kinase HEC75_RS23405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC75_RS23410 ENOG4106FIY HEC75_RS23415 ENOG4105D4P Coproporphyrinogen iii oxidase HEC75_RS23435 ENOG4105C2M dna polymerase I HEC75_RS23440 ENOG4106HNH Acyl-transferase HEC75_RS23445 ENOG4108Z33 Thiol disulfide Interchange Protein HEC75_RS23455 ENOG4105PC1 Conserved Protein HEC75_RS23460 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HEC75_RS23465 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HEC75_RS23500 ENOG4108RR8 protoporphyrinogen oxidase HEC75_RS23505 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HEC75_RS23510 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HEC75_RS23525 ENOG4105CHU acetyl-coa acetyltransferase HEC75_RS23530 ENOG4108MR7 Arylsulfotransferase HEC75_RS23535 ENOG4107QK7 reductase HEC75_RS23540 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEC75_RS23545 ENOG4105MDZ Transcriptional activator rfaH HEC75_RS23550 ENOG4105F8V Hydrolase, tatD family HEC75_RS23555 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HEC75_RS23560 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HEC75_RS23565 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEC75_RS23575 ENOG4105JC1 sterol-binding domain protein HEC75_RS23585 ENOG4105CGY Dna recombination protein HEC75_RS23590 ENOG4107SXA Phosphorylase HEC75_RS23595 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HEC75_RS23600 ENOG4105C4X radical SAM domain protein HEC75_RS23610 ENOG4105DZ2 Transcriptional regulator HEC75_RS23615 ENOG4105EMK carboxylate amino acid amine transporter HEC75_RS23620 ENOG4105DQF Hydrolase HEC75_RS23625 ENOG4108EUD Lysophospholipase HEC75_RS23630 ENOG410829K Lysine exporter protein (Lyse ygga) HEC75_RS23635 ENOG4105CCF Lysine exporter protein (Lyse ygga) HEC75_RS23640 ENOG4105C9U ATP-dependent DNA helicase RecQ HEC75_RS23645 ENOG4105HDD phospholipase HEC75_RS23650 ENOG4108VUY thioesterase Superfamily protein HEC75_RS23655 ENOG4105FR1 rard protein HEC75_RS23670 ENOG4107QUT magnesium and cobalt transport protein CorA HEC75_RS23675 ENOG4105C4R Atp-dependent dna helicase HEC75_RS23680 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HEC75_RS23685 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC75_RS23690 ENOG4105CT0 Protein of unknown function, DUF484 HEC75_RS23700 ENOG4105S7Z (LipO)protein HEC75_RS23725 ENOG4107T0K Adenylate cyclase HEC75_RS23735 ENOG41076E6 Uroporphyrinogen-III Synthase HEC75_RS23740 ENOG4105ECF c-methyltransferase HEC75_RS23745 ENOG410601J HemY protein HEC75_RS23750 ENOG4108RS6 transposase HEC75_RS23775 ENOG4105C85 amino acid HEC75_RS23795 ENOG4105EGZ biosynthesis protein HEC75_RS23800 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HEC75_RS23805 ENOG4108WJ1 acetyltransferase HEC75_RS23810 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HEC75_RS23810 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HEC75_RS23815 ENOG4105C1B dTDP-glucose 4-6-dehydratase HEC75_RS23820 ENOG4108IJ1 Dehydrogenase HEC75_RS23825 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HEC75_RS23830 ENOG4105SFE lipopolysaccharide biosynthesis protein HEC75_RS23835 ENOG4105ESV Glycosyl transferase, family 4 HEC75_RS23840 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HEC75_RS23865 ENOG4105C4R Atp-dependent dna helicase HEC75_RS23875 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HEC75_RS23885 ENOG4105EMY transcriptional regulator HEC75_RS23905 ENOG4105C7B Threonine dehydratase HEC75_RS23915 ENOG4105CM2 brancheD-chain amino acid aminotransferase HEC75_RS23920 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HEC75_RS23935 ENOG4105C0P Mg chelatase subunit ChlI HEC75_RS23980 ENOG4107EJG GntR family transcriptional regulator HEC75_RS23985 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC75_RS23990 ENOG4105ETE Transcriptional regulator (LacI family HEC75_RS23995 ENOG4108RVA ribokinase HEC75_RS24000 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEC75_RS24005 ENOG4105CNN ABC, transporter HEC75_RS24040 ENOG4108VVK transcriptional Regulator, AsnC HEC75_RS24045 ENOG4105QTB Flavodoxin HEC75_RS24060 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HEC75_RS24075 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HEC75_RS24095 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HEC75_RS24100 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HEC75_RS24120 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HEC75_RS24125 ENOG4105F9E Shikimate 5-dehydrogenase HEC75_RS24130 ENOG4105DM4 PTS System HEC75_RS24135 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HEC75_RS24140 ENOG4105C8U phosphate abc transporter HEC75_RS24145 ENOG4105E2Z phosphate ABC transporter (Permease HEC75_RS24150 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HEC75_RS24160 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HEC75_RS24165 ENOG4105C7N Xanthine uracil vitamin C permease HEC75_RS24170 ENOG4108YYH Nadph-dependent fmn reductase HEC75_RS24175 ENOG4105E8Q phosphopantetheinyl transferase HEC75_RS24210 ENOG4105VG0 50S ribosomal protein l34