locus-tag	class	description
HEC75_RS00030	COG4948	Mandelate Racemase Muconate Lactonizing
HEC75_RS00035	COG2271	Major facilitator Superfamily
HEC75_RS00040	COG0561	phosphatase activity
HEC75_RS00045	COG2186	Transcriptional regulator
HEC75_RS00050	COG3734	2-keto-3-deoxy-galactonokinase
HEC75_RS00055	COG0800	Aldolase
HEC75_RS00065	COG2271	Major facilitator Superfamily
HEC75_RS00070	COG2205	protein histidine kinase activity
HEC75_RS00070	COG2198	Histidine kinase
HEC75_RS00070	COG0784	Response regulator, receiver
HEC75_RS00075	COG1879	ABC-type sugar transport system periplasmic component
HEC75_RS00080	COG0745	RESPONSE REGULATOR receiver
HEC75_RS00085	COG3005	denitrification pathway
HEC75_RS00100	COG1858	cytochrome C peroxidase
HEC75_RS00110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC75_RS00115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC75_RS00120	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC75_RS00130	COG1138	Cytochrome C-type biogenesis protein
HEC75_RS00140	COG4235	cytochrome complex assembly
HEC75_RS00140	COG3088	subunit of a heme lyase
HEC75_RS00145	COG0823	Involved in the tonB-independent uptake of proteins
HEC75_RS00150	COG5645	(Lipo)protein
HEC75_RS00170	COG2149	membrane
HEC75_RS00180	COG0641	radical SAM
HEC75_RS00190	COG2610	gluconate transmembrane transporter activity
HEC75_RS00195	COG0583	DNA-binding transcription factor activity
HEC75_RS00205	COG2814	Major facilitator Superfamily
HEC75_RS00230	COG0028	Belongs to the TPP enzyme family
HEC75_RS00235	COG0440	acetolactate synthase activity
HEC75_RS00240	COG1349	DNA-binding transcription factor activity
HEC75_RS00250	COG0738	Major facilitator superfamily
HEC75_RS00285	COG2188	Transcriptional regulator
HEC75_RS00290	COG3711	transcriptional antiterminator
HEC75_RS00290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS00295	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC75_RS00300	COG3775	system Galactitol-specific IIC component
HEC75_RS00335	COG2723	6-phospho-beta-galactosidase activity
HEC75_RS00355	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC75_RS00355	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS00360	COG3715	PTS system
HEC75_RS00365	COG3716	PTS system mannose fructose sorbose family IID component
HEC75_RS00380	COG5464	transposase or invertase
HEC75_RS00410	COG1335	isochorismatase
HEC75_RS00420	COG3710	Transcriptional regulator
HEC75_RS00435	COG2771	luxR family
HEC75_RS00455	COG0419	ATPase involved in DNA repair
HEC75_RS00475	COG2211	Major facilitator Superfamily
HEC75_RS00480	COG1501	Belongs to the glycosyl hydrolase 31 family
HEC75_RS00485	COG2982	Protein involved in outer membrane biogenesis
HEC75_RS00490	COG2233	PERMEase
HEC75_RS00495	COG0786	glutamate:sodium symporter activity
HEC75_RS00500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEC75_RS00505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC75_RS00510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEC75_RS00530	COG2860	membrane
HEC75_RS00540	COG0583	DNA-binding transcription factor activity
HEC75_RS00545	COG1561	YicC-like family, N-terminal region
HEC75_RS00570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEC75_RS00600	COG1519	Transferase
HEC75_RS00605	COG0859	PFAM glycosyl transferase family 9
HEC75_RS00610	COG0438	transferase activity, transferring glycosyl groups
HEC75_RS00685	COG1216	Glycosyl transferase, family 2
HEC75_RS00690	COG2861	carbohydrate metabolic process
HEC75_RS00695	COG4942	peptidase
HEC75_RS00705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC75_RS00710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HEC75_RS00730	COG2271	Major facilitator Superfamily
HEC75_RS00740	COG1609	Transcriptional regulator
HEC75_RS00745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEC75_RS00755	COG2186	Transcriptional regulator
HEC75_RS00785	COG3722	fumarate hydratase activity
HEC75_RS00790	COG0246	Mannitol dehydrogenase
HEC75_RS00795	COG2213	PTS system mannitol-specific
HEC75_RS00795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS00800	COG0625	glutathione transferase activity
HEC75_RS00810	COG3276	selenocysteine insertion sequence binding
HEC75_RS00815	COG1940	carbohydrate kinase activity
HEC75_RS00820	COG1012	belongs to the aldehyde dehydrogenase family
HEC75_RS00835	COG0235	Class ii aldolase
HEC75_RS00840	COG3623	hexulose-6-phosphate isomerase
HEC75_RS00845	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HEC75_RS00850	COG1070	Carbohydrate kinase
HEC75_RS00855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEC75_RS00860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HEC75_RS00865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HEC75_RS00875	COG2731	YhcH YjgK YiaL family protein
HEC75_RS00885	COG1414	Transcriptional regulator
HEC75_RS00890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC75_RS00895	COG3977	Valine--pyruvate aminotransferase
HEC75_RS00900	COG0366	Alpha amylase catalytic
HEC75_RS00905	COG2992	FlgJ-related protein
HEC75_RS00910	COG2207	Transcriptional regulator
HEC75_RS00910	COG1609	Transcriptional regulator
HEC75_RS00915	COG2115	Belongs to the xylose isomerase family
HEC75_RS00920	COG1070	Carbohydrate kinase
HEC75_RS00925	COG4682	membrane
HEC75_RS00930	COG3274	enterobacterial common antigen metabolic process
HEC75_RS00960	COG1278	Cold shock
HEC75_RS00965	COG2944	sequence-specific DNA binding
HEC75_RS00980	COG2885	chlorophyll binding
HEC75_RS00985	COG0243	molybdopterin cofactor binding
HEC75_RS00990	COG0456	acetyltransferase
HEC75_RS00995	COG2818	Glycosylase
HEC75_RS01000	COG5571	outer membrane autotransporter
HEC75_RS01030	COG1609	Transcriptional regulator
HEC75_RS01045	COG0747	negative chemotaxis
HEC75_RS01050	COG0601	transmembrane transport
HEC75_RS01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEC75_RS01060	COG0444	Belongs to the ABC transporter superfamily
HEC75_RS01065	COG4608	Belongs to the ABC transporter superfamily
HEC75_RS01070	COG0814	amino acid
HEC75_RS01115	COG1215	transferase activity, transferring glycosyl groups
HEC75_RS01130	COG2200	EAL domain
HEC75_RS01130	COG2199	diguanylate cyclase activity
HEC75_RS01145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS01150	COG2200	EAL domain
HEC75_RS01155	COG2982	Protein involved in outer membrane biogenesis
HEC75_RS01160	COG0477	Major facilitator Superfamily
HEC75_RS01165	COG1295	ribonuclease BN
HEC75_RS01170	COG0583	DNA-binding transcription factor activity
HEC75_RS01175	COG2197	response regulator
HEC75_RS01195	COG2188	Transcriptional regulator
HEC75_RS01200	COG2222	sugar isomerase
HEC75_RS01205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS01210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC75_RS01220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC75_RS01225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEC75_RS01230	COG0671	phosphoesterase, PA-phosphatase related
HEC75_RS01260	COG0306	phosphate transporter
HEC75_RS01265	COG2081	HI0933 family
HEC75_RS01270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC75_RS01275	COG0842	Transport permease protein
HEC75_RS01275	COG1129	ABC transporter
HEC75_RS01280	COG0842	Transport permease protein
HEC75_RS01295	COG0628	permease
HEC75_RS01310	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEC75_RS01330	COG3714	YhhN family
HEC75_RS01340	COG3776	membrane
HEC75_RS01345	COG0742	ribosomal rna small subunit methyltransferase
HEC75_RS01350	COG0552	protein localization to endoplasmic reticulum
HEC75_RS01355	COG2884	Cell division ATP-binding protein ftsE
HEC75_RS01360	COG2177	Part of the ABC transporter FtsEX involved in
HEC75_RS01435	COG0584	glycerophosphoryl diester phosphodiesterase
HEC75_RS01445	COG0405	Gamma-glutamyltransferase
HEC75_RS01450	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HEC75_RS01465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS01470	COG1247	-acetyltransferase
HEC75_RS01475	COG0673	inositol 2-dehydrogenase activity
HEC75_RS01480	COG1741	Belongs to the pirin family
HEC75_RS01485	COG1609	Transcriptional regulator
HEC75_RS01490	COG3265	gluconokinase activity
HEC75_RS01495	COG2610	gluconate transmembrane transporter activity
HEC75_RS01510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEC75_RS01530	COG0058	SHG alpha-glucan phosphorylase activity
HEC75_RS01535	COG1414	Transcriptional regulator
HEC75_RS01540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEC75_RS01545	COG0129	dihydroxy-acid dehydratase activity
HEC75_RS01555	COG0371	Dehydrogenase
HEC75_RS01570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEC75_RS01585	COG1349	DNA-binding transcription factor activity
HEC75_RS01595	COG0058	SHG alpha-glucan phosphorylase activity
HEC75_RS01600	COG1640	4-alpha-glucanotransferase
HEC75_RS01605	COG2610	gluconate transmembrane transporter activity
HEC75_RS01615	COG1040	competence protein
HEC75_RS01625	COG5464	transposase or invertase
HEC75_RS01640	COG1918	ferrous iron import across plasma membrane
HEC75_RS01645	COG2183	response to ionizing radiation
HEC75_RS01650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEC75_RS01655	COG0745	RESPONSE REGULATOR receiver
HEC75_RS01670	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HEC75_RS01680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HEC75_RS01685	COG1011	Hydrolase
HEC75_RS01695	COG0494	nUDIX hydrolase
HEC75_RS01700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEC75_RS01705	COG4972	Pilus assembly protein
HEC75_RS01710	COG3166	PFAM Fimbrial assembly family protein
HEC75_RS01725	COG4796	Type ii and iii secretion system protein
HEC75_RS01740	COG3266	domain, Protein
HEC75_RS01745	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HEC75_RS01750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEC75_RS01790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEC75_RS01800	COG0738	Major facilitator superfamily
HEC75_RS01830	COG1289	transmembrane transporter activity
HEC75_RS01840	COG1765	OsmC-like protein
HEC75_RS01845	COG3954	Phosphoribulokinase
HEC75_RS01855	COG0429	hydrolase of the alpha beta-hydrolase fold
HEC75_RS01870	COG0488	(ABC) transporter
HEC75_RS01885	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HEC75_RS01890	COG1047	Peptidyl-prolyl cis-trans
HEC75_RS01900	COG0545	Peptidyl-prolyl cis-trans isomerase
HEC75_RS01905	COG2964	Protein conserved in bacteria
HEC75_RS01960	COG0051	transcription antitermination factor activity, RNA binding
HEC75_RS01985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEC75_RS02065	COG0201	protein transport
HEC75_RS02105	COG0789	Transcriptional regulator
HEC75_RS02110	COG3036	rescue of stalled ribosome
HEC75_RS02140	COG0758	DNA mediated transformation
HEC75_RS02150	COG0551	DNA topoisomerase type I activity
HEC75_RS02170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC75_RS02215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC75_RS02220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC75_RS02225	COG1309	transcriptional regulator
HEC75_RS02240	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HEC75_RS02265	COG4145	pantothenate transmembrane transporter activity
HEC75_RS02270	COG3924	membrane
HEC75_RS02275	COG0439	Biotin carboxylase
HEC75_RS02280	COG0511	ligase activity, forming carbon-carbon bonds
HEC75_RS02295	COG0604	alcohol dehydrogenase
HEC75_RS02300	COG2200	EAL domain
HEC75_RS02300	COG2199	diguanylate cyclase activity
HEC75_RS02305	COG1077	Cell shape determining protein MreB Mrl
HEC75_RS02310	COG1792	Involved in formation and maintenance of cell shape
HEC75_RS02315	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HEC75_RS02325	COG1530	ribonuclease E activity
HEC75_RS02330	COG3164	Protein of unknown function
HEC75_RS02335	COG0312	modulator of DNA gyrase
HEC75_RS02340	COG0583	DNA-binding transcription factor activity
HEC75_RS02365	COG2732	(Barnase) inhibitor
HEC75_RS02390	COG2188	Transcriptional regulator
HEC75_RS02400	COG0471	metal ion transport
HEC75_RS02405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC75_RS02410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC75_RS02415	COG3630	sodium ion export across plasma membrane
HEC75_RS02420	COG5016	pyruvate
HEC75_RS02420	COG0511	ligase activity, forming carbon-carbon bonds
HEC75_RS02425	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HEC75_RS02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEC75_RS02445	COG3105	Protein conserved in bacteria
HEC75_RS02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEC75_RS02470	COG0625	glutathione transferase activity
HEC75_RS02475	COG2969	positive regulation of protein catabolic process
HEC75_RS02505	COG2731	YhcH YjgK YiaL family protein
HEC75_RS02510	COG0402	S-adenosylhomocysteine deaminase activity
HEC75_RS02515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEC75_RS02520	COG4804	nuclease activity
HEC75_RS02525	COG0493	'glutamate synthase
HEC75_RS02530	COG0070	glutamate synthase
HEC75_RS02530	COG0067	glutamate synthase
HEC75_RS02530	COG0069	glutamate synthase activity
HEC75_RS02535	COG1242	4 iron, 4 sulfur cluster binding
HEC75_RS02540	COG2198	Histidine kinase
HEC75_RS02540	COG5002	protein histidine kinase activity
HEC75_RS02540	COG0784	Response regulator, receiver
HEC75_RS02545	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HEC75_RS02555	COG0515	serine threonine protein kinase
HEC75_RS02560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS02585	COG1137	ATPase activity
HEC75_RS02590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HEC75_RS02595	COG3117	lipopolysaccharide transmembrane transporter activity
HEC75_RS02600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEC75_RS02610	COG0530	calcium, potassium:sodium antiporter activity
HEC75_RS02615	COG1127	ABC transporter
HEC75_RS02620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEC75_RS02625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEC75_RS02630	COG2854	intermembrane phospholipid transfer
HEC75_RS02635	COG3113	response to antibiotic
HEC75_RS02640	COG5007	Belongs to the BolA IbaG family
HEC75_RS02650	COG3423	Transcriptional regulator
HEC75_RS02655	COG0142	geranyltranstransferase activity
HEC75_RS02670	COG0697	spore germination
HEC75_RS02680	COG2027	D-alanyl-D-alanine carboxypeptidase
HEC75_RS02690	COG1534	Rna-binding protein
HEC75_RS02705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEC75_RS02715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEC75_RS02785	COG0513	Belongs to the DEAD box helicase family
HEC75_RS02790	COG0814	amino acid
HEC75_RS02800	COG3034	peptidoglycan biosynthetic process
HEC75_RS02805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEC75_RS02810	COG0826	peptidase U32
HEC75_RS02815	COG0826	peptidase U32
HEC75_RS02820	COG3154	lipid carrier protein
HEC75_RS02825	COG3153	acetyltransferase
HEC75_RS02840	COG0693	protein deglycase activity
HEC75_RS02845	COG0702	epimerase
HEC75_RS02850	COG2823	Periplasmic or secreted lipoprotein
HEC75_RS02865	COG3107	peptidoglycan biosynthetic process
HEC75_RS02870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HEC75_RS02880	COG1063	alcohol dehydrogenase
HEC75_RS02885	COG3775	system Galactitol-specific IIC component
HEC75_RS02890	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC75_RS02895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS02910	COG2721	sulfolactate sulfo-lyase activity
HEC75_RS02920	COG2084	Dehydrogenase
HEC75_RS02925	COG1929	Belongs to the glycerate kinase type-1 family
HEC75_RS02935	COG0583	DNA-binding transcription factor activity
HEC75_RS02950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEC75_RS02955	COG1882	Formate acetyltransferase
HEC75_RS02960	COG1760	l-serine dehydratase
HEC75_RS02965	COG0814	amino acid
HEC75_RS02980	COG1741	Belongs to the pirin family
HEC75_RS02985	COG0583	DNA-binding transcription factor activity
HEC75_RS02990	COG3152	Membrane
HEC75_RS02995	COG0435	Glutathione S-transferase
HEC75_RS03000	COG2259	Doxx family
HEC75_RS03010	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HEC75_RS03015	COG4575	ribosome binding
HEC75_RS03020	COG1422	Protein of unknown function (DUF1090)
HEC75_RS03030	COG0586	Pfam SNARE associated Golgi protein
HEC75_RS03045	COG0673	inositol 2-dehydrogenase activity
HEC75_RS03050	COG2949	membrane
HEC75_RS03055	COG1451	nucleotide metabolic process
HEC75_RS03065	COG1902	pentaerythritol trinitrate reductase activity
HEC75_RS03065	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEC75_RS03075	COG0840	transmembrane signaling receptor activity
HEC75_RS03085	COG0840	transmembrane signaling receptor activity
HEC75_RS03090	COG1695	Transcriptional regulator
HEC75_RS03095	COG2375	cellular response to nickel ion
HEC75_RS03100	COG4974	Belongs to the 'phage' integrase family
HEC75_RS03145	COG5002	protein histidine kinase activity
HEC75_RS03145	COG2176	DNA-directed DNA polymerase activity
HEC75_RS03175	COG4695	Portal protein
HEC75_RS03270	COG5301	cellulose 1,4-beta-cellobiosidase activity
HEC75_RS03320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HEC75_RS03345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEC75_RS03360	COG4991	sh3 domain protein
HEC75_RS03365	COG3025	triphosphatase activity
HEC75_RS03385	COG2268	Band 7 protein
HEC75_RS03390	COG1585	Membrane protein implicated in regulation of membrane protease activity
HEC75_RS03430	COG3384	dioxygenase
HEC75_RS03435	COG0754	glutathionylspermidine amidase activity
HEC75_RS03450	COG0494	nUDIX hydrolase
HEC75_RS03455	COG3151	Protein conserved in bacteria
HEC75_RS03460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEC75_RS03465	COG3150	esterase
HEC75_RS03475	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HEC75_RS03480	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEC75_RS03495	COG3111	PFAM Bacterial OB fold (BOF) protein
HEC75_RS03500	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HEC75_RS03550	COG0471	metal ion transport
HEC75_RS03560	COG1979	alcohol dehydrogenase
HEC75_RS03565	COG2207	Transcriptional regulator
HEC75_RS03585	COG0848	biopolymer transport protein
HEC75_RS03590	COG1028	Short-chain dehydrogenase reductase Sdr
HEC75_RS03615	COG0840	transmembrane signaling receptor activity
HEC75_RS03625	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HEC75_RS03630	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS03635	COG5557	Pfam Polysulphide reductase, NrfD
HEC75_RS03640	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEC75_RS03645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC75_RS03650	COG1773	rubredoxin
HEC75_RS03660	COG0298	carbon dioxide binding
HEC75_RS03675	COG0625	glutathione transferase activity
HEC75_RS03680	COG0754	glutathionylspermidine amidase activity
HEC75_RS03695	COG0246	Mannitol dehydrogenase
HEC75_RS03705	COG2271	Major facilitator Superfamily
HEC75_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
HEC75_RS03735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEC75_RS03745	COG0531	amino acid
HEC75_RS03760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC75_RS03785	COG1811	Na channel or pump
HEC75_RS03885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEC75_RS04025	COG1660	Displays ATPase and GTPase activities
HEC75_RS04130	COG0697	spore germination
HEC75_RS04285	COG3550	peptidyl-serine autophosphorylation
HEC75_RS04365	COG1358	cellular component organization or biogenesis
HEC75_RS04395	COG4245	von Willebrand factor, type A
HEC75_RS04400	COG4245	von Willebrand factor, type A
HEC75_RS04545	COG0210	DNA helicase
HEC75_RS04630	COG1192	Involved in chromosome partitioning
HEC75_RS04770	COG2890	protein-(glutamine-N5) methyltransferase activity
HEC75_RS04990	COG2211	Major facilitator Superfamily
HEC75_RS05015	COG3171	Protein conserved in bacteria
HEC75_RS05025	COG0252	asparaginase activity
HEC75_RS05035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEC75_RS05040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEC75_RS05050	COG0762	integral membrane protein
HEC75_RS05055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HEC75_RS05060	COG2805	Type II/IV secretion system protein
HEC75_RS05085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEC75_RS05090	COG2356	endonuclease I
HEC75_RS05125	COG1166	arginine decarboxylase activity
HEC75_RS05135	COG0501	Belongs to the peptidase M48B family
HEC75_RS05140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEC75_RS05145	COG1122	ATPase activity
HEC75_RS05150	COG1122	ATPase activity
HEC75_RS05180	COG0191	fructose-bisphosphate aldolase activity
HEC75_RS05185	COG0668	transmembrane transport
HEC75_RS05195	COG2968	Membrane
HEC75_RS05215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEC75_RS05220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEC75_RS05240	COG0006	proline dipeptidase activity
HEC75_RS05245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC75_RS05250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC75_RS05275	COG2723	6-phospho-beta-galactosidase activity
HEC75_RS05285	COG1272	protein, Hemolysin III
HEC75_RS05345	COG4942	peptidase
HEC75_RS05390	COG3188	usher protein
HEC75_RS05425	COG0814	amino acid
HEC75_RS05440	COG0183	Belongs to the thiolase family
HEC75_RS05450	COG1028	Short-chain dehydrogenase reductase Sdr
HEC75_RS05455	COG2814	Major facilitator Superfamily
HEC75_RS05460	COG1794	racemase activity, acting on amino acids and derivatives
HEC75_RS05465	COG0583	DNA-binding transcription factor activity
HEC75_RS05475	COG1609	Transcriptional regulator
HEC75_RS05495	COG0667	Aldo Keto reductase
HEC75_RS05505	COG0861	Integral membrane protein TerC family
HEC75_RS05535	COG2165	general secretion pathway protein
HEC75_RS05540	COG4795	General secretion pathway protein
HEC75_RS05550	COG4967	type IV pilus modification protein PilV
HEC75_RS05555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEC75_RS05560	COG1025	Belongs to the peptidase M16 family
HEC75_RS05565	COG1074	ATP-dependent DNA helicase activity
HEC75_RS05570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEC75_RS05575	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HEC75_RS05575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEC75_RS05580	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEC75_RS05595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HEC75_RS05600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEC75_RS05605	COG2962	Rard protein
HEC75_RS05610	COG2166	iron-sulfur cluster assembly
HEC75_RS05615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEC75_RS05625	COG0583	DNA-binding transcription factor activity
HEC75_RS05630	COG2363	Small membrane protein
HEC75_RS05640	COG1349	DNA-binding transcription factor activity
HEC75_RS05660	COG0738	Major facilitator superfamily
HEC75_RS05665	COG0235	Class ii aldolase
HEC75_RS05670	COG1454	alcohol dehydrogenase
HEC75_RS05680	COG1760	l-serine dehydratase
HEC75_RS05685	COG0814	amino acid
HEC75_RS05690	COG1611	Belongs to the LOG family
HEC75_RS05720	COG0716	FMN binding
HEC75_RS05730	COG2271	Major facilitator Superfamily
HEC75_RS05735	COG4948	Mandelate Racemase Muconate Lactonizing
HEC75_RS05740	COG4948	Mandelate Racemase Muconate Lactonizing
HEC75_RS05745	COG1929	Belongs to the glycerate kinase type-1 family
HEC75_RS05750	COG3437	response regulator, receiver
HEC75_RS05750	COG4999	Histidine kinase
HEC75_RS05750	COG2205	protein histidine kinase activity
HEC75_RS05750	COG3850	Histidine kinase
HEC75_RS05760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEC75_RS05765	COG3609	addiction module antidote protein, CC2985 family
HEC75_RS05795	COG3539	Fimbrial protein
HEC75_RS05800	COG3121	Chaperone
HEC75_RS05805	COG3188	usher protein
HEC75_RS05810	COG3539	Fimbrial protein
HEC75_RS05815	COG3956	TIGRFAM MazG family protein
HEC75_RS05830	COG0602	queuosine metabolic process
HEC75_RS05835	COG0321	lipoyl(octanoyl) transferase activity
HEC75_RS05835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HEC75_RS05840	COG0720	synthase
HEC75_RS05865	COG1203	CRISPR-associated helicase, Cas3
HEC75_RS05880	COG1857	crispr-associated protein
HEC75_RS05895	COG1518	maintenance of DNA repeat elements
HEC75_RS05900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC75_RS05905	COG2234	aminopeptidase activity
HEC75_RS05975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEC75_RS05980	COG0163	prenyltransferase activity
HEC75_RS05990	COG1349	DNA-binding transcription factor activity
HEC75_RS05995	COG2084	Dehydrogenase
HEC75_RS06005	COG0235	Class ii aldolase
HEC75_RS06010	COG3622	Belongs to the hyi family
HEC75_RS06015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC75_RS06020	COG2610	gluconate transmembrane transporter activity
HEC75_RS06030	COG0477	Major facilitator Superfamily
HEC75_RS06110	COG2207	Transcriptional regulator
HEC75_RS06200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEC75_RS06280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC75_RS06285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC75_RS06290	COG1121	(ABC) transporter
HEC75_RS06310	COG0309	Hydrogenase expression formation protein (HypE)
HEC75_RS06315	COG0409	Hydrogenase expression formation protein
HEC75_RS06320	COG0298	carbon dioxide binding
HEC75_RS06325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEC75_RS06340	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC75_RS06345	COG0651	ATP synthesis coupled electron transport
HEC75_RS06350	COG0650	Formate hydrogenlyase subunit 4
HEC75_RS06355	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HEC75_RS06355	COG3261	NADH dehydrogenase
HEC75_RS06360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC75_RS06365	COG3260	NADH ubiquinone oxidoreductase 20
HEC75_RS06375	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC75_RS06385	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC75_RS06390	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEC75_RS06415	COG1349	DNA-binding transcription factor activity
HEC75_RS06420	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS06425	COG1028	Short-chain dehydrogenase reductase Sdr
HEC75_RS06435	COG3732	PTS system glucitol sorbitol-specific
HEC75_RS06440	COG3730	PTS system glucitol sorbitol-specific
HEC75_RS06445	COG2951	lytic endotransglycosylase activity
HEC75_RS06450	COG1546	Belongs to the CinA family
HEC75_RS06470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEC75_RS06500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC75_RS06505	COG1238	metal cluster binding
HEC75_RS06525	COG2814	Major facilitator Superfamily
HEC75_RS06530	COG1566	PFAM secretion protein HlyD family protein
HEC75_RS06535	COG1846	Transcriptional regulator
HEC75_RS06540	COG2814	Major facilitator Superfamily
HEC75_RS06580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC75_RS06590	COG4575	ribosome binding
HEC75_RS06615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC75_RS06620	COG0640	Transcriptional regulator
HEC75_RS06625	COG0401	homolog of Blt101
HEC75_RS06630	COG1652	LysM domain
HEC75_RS06635	COG1802	Transcriptional regulator
HEC75_RS06640	COG1113	amino acid transport
HEC75_RS06645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEC75_RS06650	COG1012	belongs to the aldehyde dehydrogenase family
HEC75_RS06655	COG0579	oxidoreductase
HEC75_RS06685	COG0642	Histidine kinase
HEC75_RS06690	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC75_RS06700	COG2990	Protein conserved in bacteria
HEC75_RS06720	COG2819	hydrolase of the alpha beta superfamily
HEC75_RS06785	COG0582	viral genome integration into host DNA
HEC75_RS06795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC75_RS06820	COG2867	negative regulation of translational initiation
HEC75_RS06835	COG0497	DNA recombination
HEC75_RS06855	COG4536	flavin adenine dinucleotide binding
HEC75_RS06860	COG4137	Cytochrome C assembly protein
HEC75_RS06865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEC75_RS06890	COG2199	diguanylate cyclase activity
HEC75_RS06905	COG0287	Prephenate dehydrogenase
HEC75_RS06905	COG1605	Chorismate mutase
HEC75_RS06915	COG1605	Chorismate mutase
HEC75_RS06915	COG0077	Prephenate dehydratase
HEC75_RS06925	COG4974	Belongs to the 'phage' integrase family
HEC75_RS06965	COG4695	Portal protein
HEC75_RS07055	COG5301	cellulose 1,4-beta-cellobiosidase activity
HEC75_RS07085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEC75_RS07090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC75_RS07105	COG0542	response to heat
HEC75_RS07135	COG0477	Major facilitator Superfamily
HEC75_RS07140	COG5544	Lipoprotein
HEC75_RS07145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC75_RS07160	COG3118	belongs to the thioredoxin family
HEC75_RS07165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC75_RS07185	COG0583	DNA-binding transcription factor activity
HEC75_RS07190	COG0513	Belongs to the DEAD box helicase family
HEC75_RS07225	COG3086	response to oxidative stress
HEC75_RS07265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC75_RS07270	COG0583	DNA-binding transcription factor activity
HEC75_RS07275	COG2223	nitrite transmembrane transporter activity
HEC75_RS07280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEC75_RS07285	COG1737	Transcriptional regulator
HEC75_RS07295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC75_RS07295	COG1263	PTS System
HEC75_RS07300	COG0560	Phosphoserine phosphatase
HEC75_RS07325	COG2205	protein histidine kinase activity
HEC75_RS07330	COG3170	Tfp pilus assembly protein FimV
HEC75_RS07335	COG2204	response regulator
HEC75_RS07340	COG0347	Belongs to the P(II) protein family
HEC75_RS07345	COG3104	oligopeptide transport
HEC75_RS07355	COG0531	amino acid
HEC75_RS07360	COG3710	Transcriptional regulator
HEC75_RS07370	COG1017	nitric oxide dioxygenase activity
HEC75_RS07370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC75_RS07380	COG2814	Major facilitator Superfamily
HEC75_RS07385	COG3711	transcriptional antiterminator
HEC75_RS07395	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC75_RS07440	COG0822	iron-sulfur transferase activity
HEC75_RS07460	COG0633	Ferredoxin
HEC75_RS07465	COG2975	iron-sulfur cluster assembly
HEC75_RS07485	COG2897	thiosulfate sulfurtransferase activity
HEC75_RS07490	COG2373	Large extracellular alpha-helical protein
HEC75_RS07495	COG4953	penicillin-binding protein 1C
HEC75_RS07500	COG0243	molybdopterin cofactor binding
HEC75_RS07505	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS07545	COG2976	Protein conserved in bacteria
HEC75_RS07560	COG1645	bacterial-type flagellum-dependent swarming motility
HEC75_RS07600	COG0516	GMP reductase activity
HEC75_RS07600	COG0517	IMP dehydrogenase activity
HEC75_RS07625	COG3133	Outer membrane lipoprotein
HEC75_RS07640	COG2200	EAL domain
HEC75_RS07655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEC75_RS07670	COG2233	PERMEase
HEC75_RS07680	COG1393	Belongs to the ArsC family
HEC75_RS07690	COG0628	permease
HEC75_RS07695	COG3835	regulator
HEC75_RS07700	COG2610	gluconate transmembrane transporter activity
HEC75_RS07705	COG1929	Belongs to the glycerate kinase type-1 family
HEC75_RS07710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEC75_RS07715	COG2716	regulation of RNA biosynthetic process
HEC75_RS07720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEC75_RS07725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HEC75_RS07735	COG2321	neutral zinc metallopeptidase
HEC75_RS07755	COG1393	Belongs to the ArsC family
HEC75_RS07765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC75_RS07770	COG3850	Histidine kinase
HEC75_RS07775	COG0493	'glutamate synthase
HEC75_RS07775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC75_RS07790	COG5342	invasion associated locus B
HEC75_RS07800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEC75_RS07925	COG2837	iron assimilation
HEC75_RS07945	COG4208	sulfate ABC transporter
HEC75_RS07950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEC75_RS07995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS08020	COG3530	Putative quorum-sensing-regulated virulence factor
HEC75_RS08025	COG0385	Bile acid
HEC75_RS08030	COG0583	DNA-binding transcription factor activity
HEC75_RS08040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEC75_RS08045	COG2211	Major facilitator Superfamily
HEC75_RS08055	COG0583	DNA-binding transcription factor activity
HEC75_RS08085	COG3415	Transposase
HEC75_RS08090	COG3415	Transposase
HEC75_RS08105	COG2200	EAL domain
HEC75_RS08105	COG2199	diguanylate cyclase activity
HEC75_RS08110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEC75_RS08125	COG0667	Aldo Keto reductase
HEC75_RS08130	COG3961	Belongs to the TPP enzyme family
HEC75_RS08150	COG0436	Aminotransferase
HEC75_RS08160	COG1560	Kdo2-lipid A biosynthetic process
HEC75_RS08210	COG2755	lipolytic protein G-D-S-L family
HEC75_RS08210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEC75_RS08215	COG0463	Glycosyl transferase, family 2
HEC75_RS08220	COG2246	polysaccharide biosynthetic process
HEC75_RS08240	COG2116	formate transmembrane transporter activity
HEC75_RS08255	COG3691	Protein conserved in bacteria
HEC75_RS08270	COG2062	phosphohistidine phosphatase, SixA
HEC75_RS08295	COG0730	response to heat
HEC75_RS08300	COG3101	peptidyl-lysine hydroxylation
HEC75_RS08315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC75_RS08355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEC75_RS08365	COG0586	Pfam SNARE associated Golgi protein
HEC75_RS08375	COG0285	dihydrofolate synthase activity
HEC75_RS08380	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HEC75_RS08385	COG1286	toxin biosynthetic process
HEC75_RS08390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HEC75_RS08395	COG3829	transcription factor binding
HEC75_RS08410	COG3457	Alanine racemase
HEC75_RS08415	COG0833	amino acid
HEC75_RS08450	COG1090	epimerase
HEC75_RS08455	COG0625	glutathione transferase activity
HEC75_RS08460	COG0625	glutathione transferase activity
HEC75_RS08465	COG0622	Phosphoesterase
HEC75_RS08475	COG1609	Transcriptional regulator
HEC75_RS08480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS08490	COG3037	sugar-specific permease SgaT UlaA
HEC75_RS08495	COG3959	Transketolase, thiamine diphosphate binding domain
HEC75_RS08500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEC75_RS08505	COG1288	antiporter activity
HEC75_RS08530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC75_RS08535	COG0490	domain, Protein
HEC75_RS08535	COG0471	metal ion transport
HEC75_RS08545	COG0436	Aminotransferase
HEC75_RS08550	COG0583	DNA-binding transcription factor activity
HEC75_RS08600	COG0839	Belongs to the complex I subunit 6 family
HEC75_RS08610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEC75_RS08615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC75_RS08625	COG0835	chemotaxis
HEC75_RS08625	COG0784	Response regulator, receiver
HEC75_RS08635	COG2153	protein acetylation
HEC75_RS08640	COG4575	ribosome binding
HEC75_RS08645	COG1169	isochorismate synthase
HEC75_RS08740	COG0247	lactate metabolic process
HEC75_RS08750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEC75_RS08755	COG2271	Major facilitator Superfamily
HEC75_RS08760	COG0584	glycerophosphoryl diester phosphodiesterase
HEC75_RS08765	COG0583	DNA-binding transcription factor activity
HEC75_RS08770	COG2814	Major facilitator Superfamily
HEC75_RS08775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC75_RS08805	COG4948	Mandelate Racemase Muconate Lactonizing
HEC75_RS08825	COG0642	Histidine kinase
HEC75_RS08825	COG2198	Histidine kinase
HEC75_RS08850	COG4615	Cyclic peptide transporter
HEC75_RS08860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC75_RS08860	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC75_RS08865	COG3062	negative regulation of establishment of protein localization
HEC75_RS08875	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS08880	COG0348	domain, Protein
HEC75_RS08885	COG3043	anaerobic respiration
HEC75_RS08890	COG3005	denitrification pathway
HEC75_RS08900	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC75_RS08905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC75_RS08910	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC75_RS08920	COG1138	Cytochrome C-type biogenesis protein
HEC75_RS08930	COG3088	subunit of a heme lyase
HEC75_RS08930	COG4235	cytochrome complex assembly
HEC75_RS08935	COG2197	response regulator
HEC75_RS09000	COG1061	Type III restriction enzyme res subunit
HEC75_RS09010	COG2814	Major facilitator Superfamily
HEC75_RS09020	COG4172	Belongs to the ABC transporter superfamily
HEC75_RS09025	COG4239	(ABC) transporter, permease
HEC75_RS09030	COG4174	ABC transporter (Permease)
HEC75_RS09035	COG4166	transmembrane transport
HEC75_RS09040	COG2200	EAL domain
HEC75_RS09045	COG0791	NLP P60 protein
HEC75_RS09050	COG0671	phosphoesterase, PA-phosphatase related
HEC75_RS09055	COG0523	cobalamin synthesis protein
HEC75_RS09090	COG1105	Belongs to the carbohydrate kinase PfkB family
HEC75_RS09095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC75_RS09095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC75_RS09095	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HEC75_RS09100	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HEC75_RS09105	COG2855	membrane
HEC75_RS09110	COG0583	DNA-binding transcription factor activity
HEC75_RS09115	COG0833	amino acid
HEC75_RS09120	COG4771	TonB-dependent receptor
HEC75_RS09125	COG2271	Major facilitator Superfamily
HEC75_RS09130	COG0560	Phosphoserine phosphatase
HEC75_RS09135	COG1760	l-serine dehydratase
HEC75_RS09155	COG2311	Membrane
HEC75_RS09195	COG2949	membrane
HEC75_RS09205	COG1346	cytolysis
HEC75_RS09220	COG2271	Major facilitator Superfamily
HEC75_RS09235	COG0625	glutathione transferase activity
HEC75_RS09240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC75_RS09255	COG1538	Outer membrane efflux protein
HEC75_RS09260	COG1028	Short-chain dehydrogenase reductase Sdr
HEC75_RS09265	COG0586	Pfam SNARE associated Golgi protein
HEC75_RS09275	COG1686	Belongs to the peptidase S11 family
HEC75_RS09280	COG0277	FAD linked oxidase domain protein
HEC75_RS09290	COG1732	Glycine betaine
HEC75_RS09295	COG1174	glycine betaine transport
HEC75_RS09300	COG1125	glycine betaine transport
HEC75_RS09305	COG1174	glycine betaine transport
HEC75_RS09320	COG3275	phosphorelay sensor kinase activity
HEC75_RS09330	COG4807	Protein conserved in bacteria
HEC75_RS09340	COG4808	Protein conserved in bacteria
HEC75_RS09365	COG3121	Chaperone
HEC75_RS09370	COG3188	usher protein
HEC75_RS09380	COG5455	response to cobalt ion
HEC75_RS09395	COG2188	Transcriptional regulator
HEC75_RS09400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS09405	COG1397	ADP-ribosylglycohydrolase
HEC75_RS09410	COG2211	Major facilitator Superfamily
HEC75_RS09415	COG1830	Aldolase
HEC75_RS09465	COG3209	COG3209 Rhs family protein
HEC75_RS09480	COG3209	COG3209 Rhs family protein
HEC75_RS09485	COG3209	COG3209 Rhs family protein
HEC75_RS09495	COG1413	lyase activity
HEC75_RS09500	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HEC75_RS09545	COG0745	RESPONSE REGULATOR receiver
HEC75_RS09550	COG2205	protein histidine kinase activity
HEC75_RS09610	COG4771	TonB-dependent receptor
HEC75_RS09800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEC75_RS09805	COG3447	MASE1 domain protein
HEC75_RS09805	COG5001	Diguanylate cyclase
HEC75_RS09805	COG5002	protein histidine kinase activity
HEC75_RS09820	COG2982	Protein involved in outer membrane biogenesis
HEC75_RS09825	COG1253	flavin adenine dinucleotide binding
HEC75_RS09845	COG0463	Glycosyl transferase, family 2
HEC75_RS09850	COG1045	serine acetyltransferase
HEC75_RS09855	COG0438	transferase activity, transferring glycosyl groups
HEC75_RS09865	COG1216	Glycosyl transferase, family 2
HEC75_RS09870	COG0110	maltose O-acetyltransferase activity
HEC75_RS09875	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEC75_RS09880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC75_RS09890	COG0297	glycogen (starch) synthase activity
HEC75_RS09905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEC75_RS09910	COG2244	polysaccharide biosynthetic process
HEC75_RS09915	COG2327	Polysaccharide pyruvyl transferase
HEC75_RS09960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEC75_RS10075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC75_RS10080	COG0583	DNA-binding transcription factor activity
HEC75_RS10090	COG0531	amino acid
HEC75_RS10095	COG2925	Exonuclease
HEC75_RS10135	COG1289	transmembrane transporter activity
HEC75_RS10170	COG4656	Part of a membrane complex involved in electron transport
HEC75_RS10175	COG1012	belongs to the aldehyde dehydrogenase family
HEC75_RS10175	COG1454	alcohol dehydrogenase
HEC75_RS10205	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEC75_RS10265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HEC75_RS10335	COG1122	ATPase activity
HEC75_RS10370	COG0534	Mate efflux family protein
HEC75_RS10380	COG0582	viral genome integration into host DNA
HEC75_RS10390	COG3423	Transcriptional regulator
HEC75_RS10425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEC75_RS10430	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEC75_RS10435	COG1733	regulation of RNA biosynthetic process
HEC75_RS10595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEC75_RS10605	COG0582	viral genome integration into host DNA
HEC75_RS10635	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC75_RS10645	COG1418	mRNA catabolic process
HEC75_RS10650	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEC75_RS10655	COG3727	T/G mismatch-specific endonuclease activity
HEC75_RS10660	COG0697	spore germination
HEC75_RS10665	COG2354	Protein conserved in bacteria
HEC75_RS10670	COG5475	Uncharacterized small protein (DUF2158)
HEC75_RS10775	COG0425	Belongs to the sulfur carrier protein TusA family
HEC75_RS10850	COG2197	response regulator
HEC75_RS10865	COG2197	response regulator
HEC75_RS10910	COG3012	SEC-C Motif Domain Protein
HEC75_RS10910	COG3318	Belongs to the UPF0149 family
HEC75_RS10915	COG0814	amino acid
HEC75_RS10925	COG1528	Iron-storage protein
HEC75_RS10940	COG1528	Iron-storage protein
HEC75_RS11045	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HEC75_RS11060	COG3102	Protein conserved in bacteria
HEC75_RS11080	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HEC75_RS11085	COG1801	Protein of unknown function DUF72
HEC75_RS11090	COG1335	isochorismatase
HEC75_RS11100	COG0494	nUDIX hydrolase
HEC75_RS11135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC75_RS11140	COG1121	(ABC) transporter
HEC75_RS11145	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HEC75_RS11150	COG0739	heme binding
HEC75_RS11155	COG1560	Kdo2-lipid A biosynthetic process
HEC75_RS11165	COG1737	Transcriptional regulator
HEC75_RS11170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEC75_RS11175	COG0129	dihydroxy-acid dehydratase activity
HEC75_RS11180	COG0800	Aldolase
HEC75_RS11190	COG3141	response to X-ray
HEC75_RS11200	COG2979	Protein of unknown function (DUF533)
HEC75_RS11205	COG1770	oligopeptidase
HEC75_RS11210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC75_RS11215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC75_RS11225	COG2372	response to copper ion
HEC75_RS11230	COG1276	copper resistance
HEC75_RS11240	COG0582	viral genome integration into host DNA
HEC75_RS11305	COG5562	phage envelope protein
HEC75_RS11340	COG3008	intermembrane lipid transfer
HEC75_RS11345	COG2995	paraquat-inducible protein a
HEC75_RS11350	COG1956	GAF domain-containing protein
HEC75_RS11370	COG2814	Major facilitator Superfamily
HEC75_RS11375	COG1414	Transcriptional regulator
HEC75_RS11405	COG0768	penicillin binding
HEC75_RS11410	COG2226	methyltransferase
HEC75_RS11425	COG3716	PTS system mannose fructose sorbose family IID component
HEC75_RS11430	COG3715	PTS system
HEC75_RS11435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS11435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC75_RS11440	COG1253	flavin adenine dinucleotide binding
HEC75_RS11445	COG2200	EAL domain
HEC75_RS11450	COG1760	l-serine dehydratase
HEC75_RS11470	COG0251	oxidation-reduction process
HEC75_RS11475	COG1199	ATP-dependent helicase activity
HEC75_RS11485	COG3065	identical protein binding
HEC75_RS11495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEC75_RS11505	COG2894	cell division
HEC75_RS11520	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEC75_RS11560	COG2719	SpoVR family
HEC75_RS11580	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEC75_RS11605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEC75_RS11615	COG1294	oxidase, subunit
HEC75_RS11620	COG1271	oxidase subunit
HEC75_RS11625	COG1773	rubredoxin
HEC75_RS11630	COG1999	signal sequence binding
HEC75_RS11635	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC75_RS11640	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HEC75_RS11710	COG3423	Transcriptional regulator
HEC75_RS11725	COG2003	Belongs to the UPF0758 family
HEC75_RS11745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HEC75_RS11770	COG5290	Psort location Cytoplasmic, score
HEC75_RS11805	COG2963	transposase activity
HEC75_RS11810	COG2826	transposase and inactivated derivatives, IS30 family
HEC75_RS11820	COG0582	viral genome integration into host DNA
HEC75_RS11825	COG0012	GTP binding
HEC75_RS11840	COG0659	secondary active sulfate transmembrane transporter activity
HEC75_RS11890	COG0387	Pfam Sodium calcium exchanger
HEC75_RS11895	COG4572	Cation transport regulator
HEC75_RS11900	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HEC75_RS11905	COG4932	domain protein
HEC75_RS11910	COG2197	response regulator
HEC75_RS11915	COG3850	Histidine kinase
HEC75_RS11920	COG2223	nitrite transmembrane transporter activity
HEC75_RS11925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HEC75_RS11930	COG1140	nitrate reductase beta subunit
HEC75_RS11935	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HEC75_RS11940	COG2181	nitrate reductase activity
HEC75_RS11970	COG0788	formyltetrahydrofolate deformylase activity
HEC75_RS11980	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEC75_RS11985	COG0745	RESPONSE REGULATOR receiver
HEC75_RS11990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEC75_RS12005	COG1012	belongs to the aldehyde dehydrogenase family
HEC75_RS12005	COG1454	alcohol dehydrogenase
HEC75_RS12010	COG2095	MarC family integral membrane protein
HEC75_RS12040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEC75_RS12060	COG2350	Protein conserved in bacteria
HEC75_RS12085	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEC75_RS12095	COG3546	catalase activity
HEC75_RS12100	COG3685	Protein conserved in bacteria
HEC75_RS12105	COG3685	Protein conserved in bacteria
HEC75_RS12110	COG3729	General stress protein
HEC75_RS12150	COG0009	L-threonylcarbamoyladenylate synthase
HEC75_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
HEC75_RS12170	COG0616	signal peptide processing
HEC75_RS12210	COG0671	phosphoesterase, PA-phosphatase related
HEC75_RS12215	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HEC75_RS12220	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEC75_RS12240	COG1349	DNA-binding transcription factor activity
HEC75_RS12250	COG5001	Diguanylate cyclase
HEC75_RS12260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC75_RS12260	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC75_RS12350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HEC75_RS12355	COG1842	Phage shock protein A
HEC75_RS12365	COG1983	PspC domain protein
HEC75_RS12375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC75_RS12380	COG3106	COG3106 Predicted ATPase
HEC75_RS12400	COG4948	Mandelate Racemase Muconate Lactonizing
HEC75_RS12405	COG2866	Carboxypeptidase
HEC75_RS12410	COG4166	transmembrane transport
HEC75_RS12420	COG0583	DNA-binding transcription factor activity
HEC75_RS12425	COG0656	L-ascorbic acid biosynthetic process
HEC75_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
HEC75_RS12435	COG1309	transcriptional regulator
HEC75_RS12470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HEC75_RS12490	COG0668	transmembrane transport
HEC75_RS12495	COG3182	Iron-regulated membrane protein
HEC75_RS12515	COG2840	Smr protein MutS2
HEC75_RS12520	COG0840	transmembrane signaling receptor activity
HEC75_RS12530	COG0513	Belongs to the DEAD box helicase family
HEC75_RS12550	COG2076	Multidrug Resistance protein
HEC75_RS12565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEC75_RS12565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC75_RS12565	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEC75_RS12565	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEC75_RS12575	COG3042	response to heat
HEC75_RS12580	COG3187	Heat shock protein
HEC75_RS12585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEC75_RS12590	COG2911	Protein conserved in bacteria
HEC75_RS12600	COG3784	Protein of unknown function (DUF1318)
HEC75_RS12615	COG1643	Atp-dependent helicase
HEC75_RS12620	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEC75_RS12625	COG3038	cytochrome b561
HEC75_RS12630	COG0500	methyltransferase
HEC75_RS12640	COG0765	amino acid transport
HEC75_RS12650	COG0765	amino acid transport
HEC75_RS12655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC75_RS12690	COG0840	transmembrane signaling receptor activity
HEC75_RS12695	COG0583	DNA-binding transcription factor activity
HEC75_RS12700	COG5383	Protein conserved in bacteria
HEC75_RS12705	COG2272	Belongs to the type-B carboxylesterase lipase family
HEC75_RS12710	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HEC75_RS12715	COG2353	YceI-like domain
HEC75_RS12720	COG1304	FMN binding
HEC75_RS12730	COG1349	DNA-binding transcription factor activity
HEC75_RS12735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEC75_RS12740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS12745	COG0434	BtpA family
HEC75_RS12750	COG3775	system Galactitol-specific IIC component
HEC75_RS12755	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC75_RS12765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC75_RS12770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC75_RS12775	COG1275	C4-dicarboxylate transporter malic acid transport protein
HEC75_RS12780	COG0500	methyltransferase
HEC75_RS12790	COG3135	benzoate transporter
HEC75_RS12795	COG1396	sequence-specific DNA binding
HEC75_RS12800	COG0826	peptidase U32
HEC75_RS12825	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEC75_RS12830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEC75_RS12870	COG3238	Protein conserved in bacteria
HEC75_RS12880	COG2130	NADP-dependent
HEC75_RS12885	COG1802	Transcriptional regulator
HEC75_RS12890	COG4772	TonB-dependent receptor
HEC75_RS12895	COG3391	amine dehydrogenase activity
HEC75_RS12925	COG2181	nitrate reductase activity
HEC75_RS12930	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HEC75_RS12935	COG1140	nitrate reductase beta subunit
HEC75_RS12940	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HEC75_RS12980	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS12985	COG2864	formate dehydrogenase
HEC75_RS12990	COG1064	alcohol dehydrogenase
HEC75_RS13010	COG1764	response to oxidative stress
HEC75_RS13035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEC75_RS13050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HEC75_RS13055	COG1757	Na H antiporter
HEC75_RS13060	COG1609	Transcriptional regulator
HEC75_RS13100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEC75_RS13125	COG2271	Major facilitator Superfamily
HEC75_RS13130	COG1063	alcohol dehydrogenase
HEC75_RS13135	COG2186	Transcriptional regulator
HEC75_RS13145	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HEC75_RS13150	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEC75_RS13175	COG1773	rubredoxin
HEC75_RS13200	COG3781	membrane
HEC75_RS13215	COG1012	belongs to the aldehyde dehydrogenase family
HEC75_RS13220	COG0583	DNA-binding transcription factor activity
HEC75_RS13255	COG2814	Major facilitator Superfamily
HEC75_RS13265	COG3111	PFAM Bacterial OB fold (BOF) protein
HEC75_RS13270	COG1546	Belongs to the CinA family
HEC75_RS13275	COG3729	General stress protein
HEC75_RS13285	COG4221	oxidoreductase activity
HEC75_RS13290	COG1802	Transcriptional regulator
HEC75_RS13300	COG0246	Mannitol dehydrogenase
HEC75_RS13305	COG0477	Major facilitator Superfamily
HEC75_RS13310	COG1063	alcohol dehydrogenase
HEC75_RS13330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC75_RS13345	COG0243	molybdopterin cofactor binding
HEC75_RS13350	COG0243	molybdopterin cofactor binding
HEC75_RS13355	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS13360	COG3302	dmso reductase anchor subunit
HEC75_RS13400	COG1940	carbohydrate kinase activity
HEC75_RS13405	COG0583	DNA-binding transcription factor activity
HEC75_RS13410	COG2814	Major facilitator Superfamily
HEC75_RS13420	COG3591	Belongs to the peptidase S1B family
HEC75_RS13435	COG0628	permease
HEC75_RS13440	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HEC75_RS13445	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HEC75_RS13455	COG0531	amino acid
HEC75_RS13460	COG3136	membrane protein required for alginate biosynthesis
HEC75_RS13465	COG0745	RESPONSE REGULATOR receiver
HEC75_RS13475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC75_RS13480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HEC75_RS13485	COG2205	protein histidine kinase activity
HEC75_RS13510	COG5339	Protein conserved in bacteria
HEC75_RS13525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEC75_RS13530	COG0673	inositol 2-dehydrogenase activity
HEC75_RS13580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEC75_RS13590	COG0625	glutathione transferase activity
HEC75_RS13610	COG3895	Periplasmic Protein
HEC75_RS13635	COG1566	PFAM secretion protein HlyD family protein
HEC75_RS13650	COG4989	oxidoreductase activity
HEC75_RS13655	COG3313	Fe-S protein
HEC75_RS13660	COG1309	transcriptional regulator
HEC75_RS13665	COG1902	pentaerythritol trinitrate reductase activity
HEC75_RS13680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEC75_RS13685	COG0791	NLP P60 protein
HEC75_RS13705	COG0583	DNA-binding transcription factor activity
HEC75_RS13710	COG2814	Major facilitator Superfamily
HEC75_RS13715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEC75_RS13720	COG0307	riboflavin synthase, alpha
HEC75_RS13905	COG0789	Transcriptional regulator
HEC75_RS13910	COG3272	Protein of unknown function (DUF1722)
HEC75_RS13945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS13955	COG2267	carboxylic ester hydrolase activity
HEC75_RS13960	COG0531	amino acid
HEC75_RS13980	COG4238	major outer membrane lipoprotein
HEC75_RS13985	COG1376	ErfK ybiS ycfS ynhG family protein
HEC75_RS14000	COG0719	Fe-S assembly protein
HEC75_RS14005	COG0396	ATPase activity
HEC75_RS14010	COG0719	Fe-S assembly protein
HEC75_RS14015	COG0316	Belongs to the HesB IscA family
HEC75_RS14030	COG2050	protein possibly involved in aromatic compounds catabolism
HEC75_RS14035	COG0247	lactate metabolic process
HEC75_RS14035	COG0277	FAD linked oxidase domain protein
HEC75_RS14040	COG0628	permease
HEC75_RS14055	COG0738	Major facilitator superfamily
HEC75_RS14060	COG2271	Major facilitator Superfamily
HEC75_RS14075	COG4670	ketone body catabolic process
HEC75_RS14080	COG1960	acyl-CoA dehydrogenase activity
HEC75_RS14085	COG2207	Transcriptional regulator
HEC75_RS14085	COG1917	Cupin 2, conserved barrel domain protein
HEC75_RS14090	COG2086	electron transfer activity
HEC75_RS14095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEC75_RS14100	COG0644	oxidoreductase
HEC75_RS14105	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HEC75_RS14110	COG0318	PFAM AMP-dependent synthetase and ligase
HEC75_RS14115	COG0574	Belongs to the PEP-utilizing enzyme family
HEC75_RS14115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEC75_RS14130	COG4256	Hemin uptake protein
HEC75_RS14150	COG0791	NLP P60 protein
HEC75_RS14160	COG0386	Belongs to the glutathione peroxidase family
HEC75_RS14235	COG3137	Salt-induced outer membrane protein
HEC75_RS14240	COG1105	Belongs to the carbohydrate kinase PfkB family
HEC75_RS14250	COG3001	Fructosamine kinase
HEC75_RS14260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC75_RS14265	COG1988	membrane-bound metal-dependent
HEC75_RS14280	COG0753	catalase activity
HEC75_RS14305	COG1447	Phosphotransferase system cellobiose-specific component IIA
HEC75_RS14310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC75_RS14315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC75_RS14320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC75_RS14335	COG3678	ATP-independent chaperone mediated protein folding
HEC75_RS14370	COG0494	nUDIX hydrolase
HEC75_RS14385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEC75_RS14395	COG0778	Nitroreductase
HEC75_RS14400	COG0616	signal peptide processing
HEC75_RS14405	COG0252	asparaginase activity
HEC75_RS14410	COG1335	isochorismatase
HEC75_RS14415	COG3139	Protein of unknown function (DUF1315)
HEC75_RS14435	COG0656	L-ascorbic acid biosynthetic process
HEC75_RS14440	COG0641	radical SAM
HEC75_RS14445	COG3713	MltA-interacting MipA family protein
HEC75_RS14450	COG2766	serine protein kinase
HEC75_RS14465	COG2199	diguanylate cyclase activity
HEC75_RS14470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC75_RS14485	COG2207	Transcriptional regulator
HEC75_RS14490	COG2807	transmembrane transport
HEC75_RS14495	COG3189	MarR family transcriptional regulator
HEC75_RS14505	COG3042	response to heat
HEC75_RS14515	COG2261	transglycosylase associated protein
HEC75_RS14530	COG3615	Tellurite resistance protein tehB
HEC75_RS14540	COG1605	Chorismate mutase
HEC75_RS14555	COG0789	Transcriptional regulator
HEC75_RS14570	COG3443	Belongs to the bacterial solute-binding protein 9 family
HEC75_RS14585	COG0668	transmembrane transport
HEC75_RS14590	COG1124	(ABC) transporter
HEC75_RS14620	COG3038	cytochrome b561
HEC75_RS14630	COG0071	Belongs to the small heat shock protein (HSP20) family
HEC75_RS14680	COG3021	interspecies interaction between organisms
HEC75_RS14715	COG0538	isocitrate dehydrogenase activity
HEC75_RS14745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEC75_RS14760	COG2850	peptidyl-arginine hydroxylation
HEC75_RS14790	COG1177	transmembrane transport
HEC75_RS14810	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEC75_RS14815	COG1136	(ABC) transporter
HEC75_RS14820	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEC75_RS14825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEC75_RS14830	COG1376	ErfK ybiS ycfS ynhG family protein
HEC75_RS14830	COG1388	LysM domain
HEC75_RS14840	COG1309	transcriptional regulator
HEC75_RS14845	COG3134	Outer membrane lipoprotein
HEC75_RS14850	COG1252	NADH dehydrogenase
HEC75_RS14875	COG5633	Lipoprotein
HEC75_RS14880	COG0537	adenosine 5'-monophosphoramidase activity
HEC75_RS14885	COG4773	Receptor
HEC75_RS14895	COG0084	hydrolase, TatD family'
HEC75_RS14900	COG0470	DNA polymerase III
HEC75_RS14910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEC75_RS14915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEC75_RS14920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC75_RS14940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEC75_RS14965	COG0564	pseudouridine synthase activity
HEC75_RS14970	COG1530	ribonuclease E activity
HEC75_RS15060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC75_RS15070	COG2999	glutathione oxidoreductase activity
HEC75_RS15105	COG3038	cytochrome b561
HEC75_RS15120	COG1560	Kdo2-lipid A biosynthetic process
HEC75_RS15135	COG5645	(Lipo)protein
HEC75_RS15140	COG2943	transferase activity, transferring hexosyl groups
HEC75_RS15155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC75_RS15215	COG3381	protein complex oligomerization
HEC75_RS15285	COG0673	inositol 2-dehydrogenase activity
HEC75_RS15290	COG2814	Major facilitator Superfamily
HEC75_RS15310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEC75_RS15315	COG1737	Transcriptional regulator
HEC75_RS15320	COG1702	phosphate starvation-inducible protein PhoH
HEC75_RS15340	COG1309	transcriptional regulator
HEC75_RS15345	COG3729	General stress protein
HEC75_RS15365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEC75_RS15370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEC75_RS15370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEC75_RS15375	COG4232	protein-disulfide reductase activity
HEC75_RS15420	COG3971	2-oxopent-4-enoate hydratase activity
HEC75_RS15430	COG3384	dioxygenase
HEC75_RS15435	COG1012	belongs to the aldehyde dehydrogenase family
HEC75_RS15445	COG1846	Transcriptional regulator
HEC75_RS15450	COG2368	4-hydroxyphenylacetate
HEC75_RS15465	COG0745	RESPONSE REGULATOR receiver
HEC75_RS15470	COG2205	protein histidine kinase activity
HEC75_RS15520	COG0670	Belongs to the BI1 family
HEC75_RS15540	COG1881	PFAM PEBP family protein
HEC75_RS15555	COG1832	CoA-binding protein
HEC75_RS15570	COG0210	DNA helicase
HEC75_RS15575	COG3304	Inner membrane component domain
HEC75_RS15580	COG1289	transmembrane transporter activity
HEC75_RS15585	COG3070	regulator of competence-specific genes
HEC75_RS15605	COG1067	ATP-dependent peptidase activity
HEC75_RS15615	COG3130	regulation of translation
HEC75_RS15620	COG3009	Protein conserved in bacteria
HEC75_RS15625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEC75_RS15625	COG3008	intermembrane lipid transfer
HEC75_RS15630	COG2995	paraquat-inducible protein a
HEC75_RS15635	COG0488	(ABC) transporter
HEC75_RS15645	COG3217	Mosc domain protein beta barrel domain protein
HEC75_RS15645	COG0633	Ferredoxin
HEC75_RS15660	COG0308	aminopeptidase N
HEC75_RS15670	COG0017	Asparaginyl-tRNA synthetase
HEC75_RS15675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC75_RS15680	COG1448	Aminotransferase
HEC75_RS15685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEC75_RS15690	COG3108	Peptidase M15
HEC75_RS15695	COG2989	Protein conserved in bacteria
HEC75_RS15705	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HEC75_RS15715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEC75_RS15720	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEC75_RS15725	COG3173	Aminoglycoside phosphotransferase
HEC75_RS15740	COG3214	Protein conserved in bacteria
HEC75_RS15755	COG0658	competence protein
HEC75_RS15755	COG2333	competence protein COMEC
HEC75_RS15765	COG0539	negative regulation of cytoplasmic translation
HEC75_RS15775	COG0501	Belongs to the peptidase M48B family
HEC75_RS15790	COG2323	membrane
HEC75_RS15795	COG1944	ATP diphosphatase activity
HEC75_RS15800	COG2116	formate transmembrane transporter activity
HEC75_RS15805	COG1882	Formate acetyltransferase
HEC75_RS15820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC75_RS15825	COG0531	amino acid
HEC75_RS15835	COG3302	dmso reductase anchor subunit
HEC75_RS15840	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS15845	COG0243	molybdopterin cofactor binding
HEC75_RS15855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEC75_RS15875	COG0492	ferredoxin-NADP+ reductase activity
HEC75_RS15880	COG4988	ABC transporter
HEC75_RS15885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEC75_RS15905	COG0583	DNA-binding transcription factor activity
HEC75_RS15915	COG1335	isochorismatase
HEC75_RS15935	COG0542	response to heat
HEC75_RS15945	COG1278	Cold shock
HEC75_RS15950	COG1136	(ABC) transporter
HEC75_RS15950	COG0577	efflux transmembrane transporter activity
HEC75_RS15955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC75_RS15960	COG2990	Protein conserved in bacteria
HEC75_RS15965	COG3593	DNA synthesis involved in DNA repair
HEC75_RS15970	COG2431	L-lysine efflux transmembrane transporter activity
HEC75_RS15980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC75_RS15985	COG0028	Belongs to the TPP enzyme family
HEC75_RS15990	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HEC75_RS15995	COG0702	epimerase
HEC75_RS16000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC75_RS16005	COG3023	N-Acetylmuramoyl-L-alanine amidase
HEC75_RS16020	COG1126	abc transporter atp-binding protein
HEC75_RS16025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC75_RS16030	COG4215	(ABC) transporter
HEC75_RS16035	COG4160	amino acid transport
HEC75_RS16040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC75_RS16070	COG1177	transmembrane transport
HEC75_RS16075	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEC75_RS16080	COG3842	ATPase activity
HEC75_RS16085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEC75_RS16125	COG3226	Transcriptional regulator
HEC75_RS16130	COG0738	Major facilitator superfamily
HEC75_RS16135	COG0561	phosphatase activity
HEC75_RS16140	COG2814	Major facilitator Superfamily
HEC75_RS16145	COG0671	phosphoesterase, PA-phosphatase related
HEC75_RS16150	COG1349	DNA-binding transcription factor activity
HEC75_RS16155	COG1686	Belongs to the peptidase S11 family
HEC75_RS16160	COG0625	glutathione transferase activity
HEC75_RS16165	COG2133	pyrroloquinoline quinone binding
HEC75_RS16190	COG0747	negative chemotaxis
HEC75_RS16215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC75_RS16220	COG1882	Formate acetyltransferase
HEC75_RS16225	COG0561	phosphatase activity
HEC75_RS16235	COG0488	(ABC) transporter
HEC75_RS16240	COG1376	ErfK ybiS ycfS ynhG family protein
HEC75_RS16245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HEC75_RS16260	COG2194	sulfuric ester hydrolase activity
HEC75_RS16265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HEC75_RS16280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC75_RS16285	COG0765	amino acid transport
HEC75_RS16290	COG1126	abc transporter atp-binding protein
HEC75_RS16295	COG0668	transmembrane transport
HEC75_RS16305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEC75_RS16315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEC75_RS16325	COG0513	Belongs to the DEAD box helicase family
HEC75_RS16330	COG1309	transcriptional regulator
HEC75_RS16335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC75_RS16340	COG1131	(ABC) transporter
HEC75_RS16345	COG0842	Transport permease protein
HEC75_RS16350	COG0842	Transport permease protein
HEC75_RS16360	COG3568	Endonuclease Exonuclease Phosphatase
HEC75_RS16365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC75_RS16370	COG0392	lysyltransferase activity
HEC75_RS16385	COG0670	Belongs to the BI1 family
HEC75_RS16395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEC75_RS16405	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEC75_RS16430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEC75_RS16455	COG1881	PFAM PEBP family protein
HEC75_RS16485	COG4677	pectinesterase activity
HEC75_RS16495	COG0561	phosphatase activity
HEC75_RS16505	COG4149	molybdate abc transporter
HEC75_RS16510	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEC75_RS16520	COG3585	molybdate ion transport
HEC75_RS16520	COG2005	Transcriptional regulator
HEC75_RS16525	COG1119	ATPase activity
HEC75_RS16550	COG2017	converts alpha-aldose to the beta-anomer
HEC75_RS16560	COG1120	ATPase activity
HEC75_RS16565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC75_RS16575	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HEC75_RS16580	COG0511	ligase activity, forming carbon-carbon bonds
HEC75_RS16580	COG5016	pyruvate
HEC75_RS16590	COG0471	metal ion transport
HEC75_RS16590	COG0490	domain, Protein
HEC75_RS16595	COG0583	DNA-binding transcription factor activity
HEC75_RS16600	COG0583	DNA-binding transcription factor activity
HEC75_RS16610	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC75_RS16610	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC75_RS16615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEC75_RS16625	COG1230	cation diffusion facilitator family transporter
HEC75_RS16670	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HEC75_RS16675	COG2885	chlorophyll binding
HEC75_RS16685	COG3064	Membrane
HEC75_RS16690	COG0848	biopolymer transport protein
HEC75_RS16695	COG0811	peptide transport
HEC75_RS16700	COG0824	Thioesterase
HEC75_RS16705	COG3790	cyd operon protein YbgE
HEC75_RS16710	COG4890	Cyd operon protein YbgT
HEC75_RS16715	COG1294	oxidase, subunit
HEC75_RS16720	COG1271	oxidase subunit
HEC75_RS16725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC75_RS16735	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEC75_RS16740	COG0567	Dehydrogenase, E1 component
HEC75_RS16755	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEC75_RS16775	COG3180	Ammonia monooxygenase
HEC75_RS16790	COG1984	allophanate hydrolase subunit 2
HEC75_RS16795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HEC75_RS16840	COG2205	protein histidine kinase activity
HEC75_RS16845	COG0745	RESPONSE REGULATOR receiver
HEC75_RS16855	COG1982	Orn Lys Arg decarboxylase major
HEC75_RS16860	COG0531	amino acid
HEC75_RS16870	COG0033	Phosphoglucomutase
HEC75_RS16880	COG0596	Alpha beta hydrolase
HEC75_RS16895	COG0735	belongs to the Fur family
HEC75_RS16900	COG0583	DNA-binding transcription factor activity
HEC75_RS16905	COG1053	succinate dehydrogenase
HEC75_RS16945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEC75_RS16950	COG1846	Transcriptional regulator
HEC75_RS16950	COG1940	carbohydrate kinase activity
HEC75_RS16955	COG0647	UMP catabolic process
HEC75_RS16960	COG0367	asparagine synthase
HEC75_RS17000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC75_RS17010	COG1702	phosphate starvation-inducible protein PhoH
HEC75_RS17035	COG0765	amino acid transport
HEC75_RS17040	COG0765	amino acid transport
HEC75_RS17045	COG1126	abc transporter atp-binding protein
HEC75_RS17060	COG2888	peptidyl-tyrosine sulfation
HEC75_RS17065	COG3829	transcription factor binding
HEC75_RS17065	COG3290	protein histidine kinase activity
HEC75_RS17095	COG1466	dna polymerase III delta subunit
HEC75_RS17105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEC75_RS17115	COG0799	negative regulation of ribosome biogenesis
HEC75_RS17125	COG0768	penicillin binding
HEC75_RS17130	COG0772	Belongs to the SEDS family
HEC75_RS17135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEC75_RS17140	COG1686	Belongs to the peptidase S11 family
HEC75_RS17155	COG0583	DNA-binding transcription factor activity
HEC75_RS17170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC75_RS17190	COG3069	C4-dicarboxylate transmembrane transporter activity
HEC75_RS17195	COG4565	transcriptional regulatory protein
HEC75_RS17205	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HEC75_RS17215	COG2301	Belongs to the HpcH HpaI aldolase family
HEC75_RS17220	COG3051	citrate lyase alpha subunit
HEC75_RS17235	COG0471	metal ion transport
HEC75_RS17240	COG3719	Belongs to the RNase T2 family
HEC75_RS17245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEC75_RS17250	COG1063	alcohol dehydrogenase
HEC75_RS17270	COG0243	molybdopterin cofactor binding
HEC75_RS17290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEC75_RS17295	COG0583	DNA-binding transcription factor activity
HEC75_RS17300	COG3969	phosphoadenosine phosphosulfate
HEC75_RS17305	COG1475	DNA binding
HEC75_RS17310	COG0436	Aminotransferase
HEC75_RS17315	COG0371	Dehydrogenase
HEC75_RS17320	COG2879	small protein
HEC75_RS17325	COG1966	Carbon starvation protein
HEC75_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
HEC75_RS17340	COG1535	isochorismatase
HEC75_RS17340	COG3433	isochorismatase activity
HEC75_RS17345	COG1021	2,3-dihydroxybenzoate-AMP ligase
HEC75_RS17350	COG1169	isochorismate synthase
HEC75_RS17355	COG4592	Periplasmic binding protein
HEC75_RS17365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC75_RS17370	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC75_RS17375	COG1120	ATPase activity
HEC75_RS17380	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HEC75_RS17385	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HEC75_RS17385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEC75_RS17390	COG3251	PFAM MbtH domain protein
HEC75_RS17395	COG2382	esterase
HEC75_RS17400	COG4771	TonB-dependent receptor
HEC75_RS17405	COG2977	Belongs to the P-Pant transferase superfamily
HEC75_RS17430	COG2315	Protein conserved in bacteria
HEC75_RS17445	COG0668	transmembrane transport
HEC75_RS17450	COG1113	amino acid transport
HEC75_RS17460	COG3059	membrane
HEC75_RS17470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC75_RS17475	COG2207	Transcriptional regulator
HEC75_RS17495	COG2246	polysaccharide biosynthetic process
HEC75_RS17500	COG0463	Glycosyl transferase, family 2
HEC75_RS17580	COG2501	S4 domain
HEC75_RS17585	COG1988	membrane-bound metal-dependent
HEC75_RS17605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEC75_RS17615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEC75_RS17620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HEC75_RS17625	COG0549	Belongs to the carbamate kinase family
HEC75_RS17635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC75_RS17640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC75_RS17645	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HEC75_RS17650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEC75_RS17655	COG3257	ureidoglycine aminohydrolase activity
HEC75_RS17660	COG1929	Belongs to the glycerate kinase type-1 family
HEC75_RS17665	COG2233	PERMEase
HEC75_RS17675	COG1953	Uracil, thiamine, allantoin
HEC75_RS17685	COG2084	Dehydrogenase
HEC75_RS17690	COG3622	Belongs to the hyi family
HEC75_RS17695	COG3960	tartronate-semialdehyde synthase activity
HEC75_RS17730	COG1464	Belongs to the NlpA lipoprotein family
HEC75_RS17740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEC75_RS17745	COG4181	ATPase activity
HEC75_RS17750	COG2755	lipolytic protein G-D-S-L family
HEC75_RS17755	COG0300	oxidoreductase activity
HEC75_RS17760	COG3118	belongs to the thioredoxin family
HEC75_RS17765	COG0390	transport system, permease component
HEC75_RS17770	COG4619	ABC transporter
HEC75_RS17775	COG0330	HflC and HflK could
HEC75_RS17780	COG1585	Membrane protein implicated in regulation of membrane protease activity
HEC75_RS17790	COG2217	Heavy metal translocating P-type atpase
HEC75_RS17800	COG3735	TraB family
HEC75_RS17815	COG2223	nitrite transmembrane transporter activity
HEC75_RS17820	COG4651	solute:proton antiporter activity
HEC75_RS17820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEC75_RS17825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS17870	COG2832	Protein of unknown function (DUF454)
HEC75_RS17875	COG3923	Primosomal replication protein n
HEC75_RS17885	COG5464	transposase or invertase
HEC75_RS17890	COG3264	Mechanosensitive ion channel
HEC75_RS17890	COG1196	nuclear chromosome segregation
HEC75_RS17895	COG1309	transcriptional regulator
HEC75_RS17900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC75_RS17905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC75_RS17920	COG0110	maltose O-acetyltransferase activity
HEC75_RS17940	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HEC75_RS17950	COG3695	enzyme binding
HEC75_RS17955	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HEC75_RS17960	COG1946	Acyl-CoA thioesterase
HEC75_RS17965	COG0004	ammonium transporteR
HEC75_RS17970	COG0347	Belongs to the P(II) protein family
HEC75_RS17975	COG1132	(ABC) transporter
HEC75_RS17980	COG1132	(ABC) transporter
HEC75_RS17985	COG1522	sequence-specific DNA binding
HEC75_RS18000	COG4533	DNA binding
HEC75_RS18010	COG0824	Thioesterase
HEC75_RS18015	COG1555	photosystem II stabilization
HEC75_RS18020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEC75_RS18030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEC75_RS18050	COG0271	Belongs to the BolA IbaG family
HEC75_RS18055	COG3056	Lipoprotein
HEC75_RS18060	COG2223	nitrite transmembrane transporter activity
HEC75_RS18065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEC75_RS18070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEC75_RS18075	COG1845	cytochrome c oxidase, subunit III
HEC75_RS18080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEC75_RS18100	COG2814	Major facilitator Superfamily
HEC75_RS18130	COG2188	Transcriptional regulator
HEC75_RS18165	COG0142	geranyltranstransferase activity
HEC75_RS18175	COG0667	Aldo Keto reductase
HEC75_RS18180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HEC75_RS18200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEC75_RS18200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEC75_RS18210	COG4238	major outer membrane lipoprotein
HEC75_RS18240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEC75_RS18250	COG1862	Preprotein translocase
HEC75_RS18270	COG0450	alkyl hydroperoxide reductase
HEC75_RS18280	COG0366	Alpha amylase catalytic
HEC75_RS18295	COG5002	protein histidine kinase activity
HEC75_RS18305	COG0420	3'-5' exonuclease activity
HEC75_RS18310	COG0419	ATPase involved in DNA repair
HEC75_RS18315	COG2814	Major facilitator Superfamily
HEC75_RS18320	COG1940	carbohydrate kinase activity
HEC75_RS18335	COG4126	flavin adenine dinucleotide binding
HEC75_RS18355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEC75_RS18360	COG3706	GGDEF domain
HEC75_RS18405	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HEC75_RS18410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEC75_RS18425	COG0113	porphobilinogen synthase activity
HEC75_RS18460	COG1280	lysine exporter protein (LysE YggA)
HEC75_RS18480	COG1294	oxidase, subunit
HEC75_RS18485	COG1271	oxidase subunit
HEC75_RS18505	COG2814	Major facilitator Superfamily
HEC75_RS18515	COG0789	Transcriptional regulator
HEC75_RS18570	COG2200	EAL domain
HEC75_RS18585	COG3539	Fimbrial protein
HEC75_RS18590	COG3121	Chaperone
HEC75_RS18595	COG3188	usher protein
HEC75_RS18615	COG2246	polysaccharide biosynthetic process
HEC75_RS18620	COG0463	Glycosyl transferase, family 2
HEC75_RS18735	COG3772	lysozyme
HEC75_RS18745	COG0484	heat shock protein binding
HEC75_RS18800	COG0305	Participates in initiation and elongation during chromosome replication
HEC75_RS18885	COG4712	double-strand break repair protein
HEC75_RS18940	COG0582	viral genome integration into host DNA
HEC75_RS18980	COG2195	Cleaves the N-terminal amino acid of tripeptides
HEC75_RS18985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEC75_RS18990	COG1690	Belongs to the RtcB family
HEC75_RS19000	COG3034	peptidoglycan biosynthetic process
HEC75_RS19005	COG0121	glutamine amidotransferase
HEC75_RS19025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC75_RS19055	COG1522	sequence-specific DNA binding
HEC75_RS19180	COG3501	Rhs element vgr protein
HEC75_RS19225	COG2885	chlorophyll binding
HEC75_RS19225	COG3047	cAMP biosynthetic process
HEC75_RS19330	COG2226	methyltransferase
HEC75_RS19340	COG0741	lytic transglycosylase activity
HEC75_RS19340	COG1388	LysM domain
HEC75_RS19345	COG2226	methyltransferase
HEC75_RS19355	COG2814	Major facilitator Superfamily
HEC75_RS19360	COG0583	DNA-binding transcription factor activity
HEC75_RS19365	COG0656	L-ascorbic acid biosynthetic process
HEC75_RS19400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HEC75_RS19425	COG1720	tRNA m6t6A37 methyltransferase activity
HEC75_RS19435	COG3015	lipoprotein NlpE involved in copper resistance
HEC75_RS19440	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEC75_RS19455	COG4568	rho-dependent transcription termination
HEC75_RS19465	COG0346	lactoylglutathione lyase activity
HEC75_RS19530	COG0575	Belongs to the CDS family
HEC75_RS19580	COG0477	Major facilitator Superfamily
HEC75_RS19590	COG3835	regulator
HEC75_RS19610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEC75_RS19615	COG2860	membrane
HEC75_RS19645	COG3539	Fimbrial protein
HEC75_RS19650	COG3539	Fimbrial protein
HEC75_RS19655	COG3121	Chaperone
HEC75_RS19660	COG3188	usher protein
HEC75_RS19680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEC75_RS19685	COG1120	ATPase activity
HEC75_RS19690	COG4774	siderophore transport
HEC75_RS19695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEC75_RS19700	COG1643	Atp-dependent helicase
HEC75_RS19705	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HEC75_RS19730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEC75_RS19755	COG3121	Chaperone
HEC75_RS19760	COG3188	usher protein
HEC75_RS19765	COG3539	Fimbrial protein
HEC75_RS19785	COG0726	polysaccharide deacetylase
HEC75_RS19790	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS19795	COG0842	Transport permease protein
HEC75_RS19800	COG1131	(ABC) transporter
HEC75_RS19805	COG0288	reversible hydration of carbon dioxide
HEC75_RS19815	COG4993	Dehydrogenase
HEC75_RS19820	COG2132	Multicopper oxidase
HEC75_RS19840	COG1349	DNA-binding transcription factor activity
HEC75_RS19870	COG3064	Membrane
HEC75_RS19885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC75_RS19890	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEC75_RS19895	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEC75_RS19910	COG2211	Major facilitator Superfamily
HEC75_RS19915	COG3940	Belongs to the glycosyl hydrolase 43 family
HEC75_RS19920	COG3725	Membrane protein required for beta-lactamase induction
HEC75_RS19935	COG4969	Belongs to the N-Me-Phe pilin family
HEC75_RS19940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEC75_RS19945	COG1459	type II secretion system
HEC75_RS19980	COG0494	nUDIX hydrolase
HEC75_RS20000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEC75_RS20005	COG0849	cell division
HEC75_RS20030	COG0772	Belongs to the SEDS family
HEC75_RS20045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEC75_RS20055	COG0768	penicillin binding
HEC75_RS20150	COG0586	Pfam SNARE associated Golgi protein
HEC75_RS20190	COG0417	DNA replication proofreading
HEC75_RS20210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HEC75_RS20220	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEC75_RS20255	COG3119	arylsulfatase activity
HEC75_RS20275	COG2271	Major facilitator Superfamily
HEC75_RS20285	COG0644	oxidoreductase
HEC75_RS20395	COG5016	pyruvate
HEC75_RS20395	COG0511	ligase activity, forming carbon-carbon bonds
HEC75_RS20400	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HEC75_RS20430	COG1047	Peptidyl-prolyl cis-trans
HEC75_RS20445	COG0196	riboflavin kinase activity
HEC75_RS20470	COG0583	DNA-binding transcription factor activity
HEC75_RS20490	COG0641	radical SAM
HEC75_RS20495	COG3119	arylsulfatase activity
HEC75_RS20505	COG0737	Belongs to the 5'-nucleotidase family
HEC75_RS20540	COG3121	Chaperone
HEC75_RS20545	COG3539	Fimbrial protein
HEC75_RS20560	COG3188	usher protein
HEC75_RS20625	COG4735	regulation of single-species biofilm formation
HEC75_RS20630	COG1584	GPR1 FUN34 yaaH family protein
HEC75_RS20635	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEC75_RS20645	COG1115	amino acid carrier protein
HEC75_RS20655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEC75_RS20665	COG0527	aspartate kinase activity
HEC75_RS20665	COG0460	homoserine dehydrogenase
HEC75_RS20675	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HEC75_RS20685	COG0745	RESPONSE REGULATOR receiver
HEC75_RS20705	COG3121	Chaperone
HEC75_RS20725	COG4452	Inner membrane protein CreD
HEC75_RS20730	COG2205	protein histidine kinase activity
HEC75_RS20735	COG0745	RESPONSE REGULATOR receiver
HEC75_RS20740	COG3045	CreA protein
HEC75_RS20745	COG2207	Transcriptional regulator
HEC75_RS20745	COG3708	Transcriptional regulator
HEC75_RS20770	COG0488	(ABC) transporter
HEC75_RS20785	COG0560	Phosphoserine phosphatase
HEC75_RS20790	COG3726	membrane protein affecting hemolysin expression
HEC75_RS20825	COG1328	CTP reductase activity
HEC75_RS20830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC75_RS20835	COG0084	hydrolase, TatD family'
HEC75_RS20840	COG4667	esterase of the alpha-beta hydrolase superfamily
HEC75_RS20850	COG2823	Periplasmic or secreted lipoprotein
HEC75_RS20860	COG1011	Hydrolase
HEC75_RS20870	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HEC75_RS20900	COG3706	GGDEF domain
HEC75_RS20905	COG4114	ferric iron reductase
HEC75_RS20910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC75_RS20915	COG2197	response regulator
HEC75_RS20920	COG2197	response regulator
HEC75_RS20925	COG2966	Psort location CytoplasmicMembrane, score
HEC75_RS20940	COG1484	DNA-dependent DNA replication
HEC75_RS20955	COG0840	transmembrane signaling receptor activity
HEC75_RS20960	COG1966	Carbon starvation protein
HEC75_RS20965	COG2879	small protein
HEC75_RS20970	COG0523	cobalamin synthesis protein
HEC75_RS20980	COG1280	lysine exporter protein (LysE YggA)
HEC75_RS20985	COG3586	endonuclease activity
HEC75_RS21000	COG1012	belongs to the aldehyde dehydrogenase family
HEC75_RS21005	COG5464	transposase or invertase
HEC75_RS21015	COG2733	membrane
HEC75_RS21020	COG0477	Major facilitator Superfamily
HEC75_RS21025	COG3366	ferrous iron transmembrane transporter activity
HEC75_RS21030	COG0700	Nucleoside recognition
HEC75_RS21035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEC75_RS21040	COG0583	DNA-binding transcription factor activity
HEC75_RS21060	COG2186	Transcriptional regulator
HEC75_RS21065	COG0412	Dienelactone hydrolase
HEC75_RS21090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HEC75_RS21160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEC75_RS21165	COG0464	growth
HEC75_RS21170	COG1404	Belongs to the peptidase S8 family
HEC75_RS21175	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HEC75_RS21185	COG0582	viral genome integration into host DNA
HEC75_RS21195	COG1064	alcohol dehydrogenase
HEC75_RS21200	COG3265	gluconokinase activity
HEC75_RS21205	COG1063	alcohol dehydrogenase
HEC75_RS21210	COG1028	Short-chain dehydrogenase reductase Sdr
HEC75_RS21215	COG2610	gluconate transmembrane transporter activity
HEC75_RS21220	COG1609	Transcriptional regulator
HEC75_RS21225	COG0795	lipopolysaccharide-transporting ATPase activity
HEC75_RS21230	COG0795	lipopolysaccharide-transporting ATPase activity
HEC75_RS21240	COG2927	DNA polymerase III (CHI subunit)
HEC75_RS21285	COG2731	YhcH YjgK YiaL family protein
HEC75_RS21305	COG1288	antiporter activity
HEC75_RS21310	COG1438	arginine binding
HEC75_RS21355	COG1263	PTS System
HEC75_RS21355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC75_RS21360	COG0366	Alpha amylase catalytic
HEC75_RS21375	COG2026	Addiction module toxin, RelE StbE family
HEC75_RS21380	COG3077	Addiction module antitoxin, RelB DinJ family
HEC75_RS21385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC75_RS21385	COG3711	transcriptional antiterminator
HEC75_RS21400	COG3964	amidohydrolase
HEC75_RS21435	COG0312	modulator of DNA gyrase
HEC75_RS21445	COG1082	Xylose isomerase domain protein TIM barrel
HEC75_RS21455	COG2814	Major facilitator Superfamily
HEC75_RS21460	COG0673	inositol 2-dehydrogenase activity
HEC75_RS21465	COG3962	Belongs to the TPP enzyme family
HEC75_RS21470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS21480	COG1082	Xylose isomerase domain protein TIM barrel
HEC75_RS21485	COG5520	Belongs to the glycosyl hydrolase 30 family
HEC75_RS21515	COG3718	enzyme involved in inositol metabolism
HEC75_RS21520	COG0477	Major facilitator Superfamily
HEC75_RS21520	COG2814	Major facilitator Superfamily
HEC75_RS21525	COG2814	Major facilitator Superfamily
HEC75_RS21525	COG0477	Major facilitator Superfamily
HEC75_RS21530	COG1737	Transcriptional regulator
HEC75_RS21530	COG0837	glucose binding
HEC75_RS21535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEC75_RS21550	COG3964	amidohydrolase
HEC75_RS21555	COG2271	Major facilitator Superfamily
HEC75_RS21560	COG2105	PFAM AIG2 family protein
HEC75_RS21580	COG1253	flavin adenine dinucleotide binding
HEC75_RS21590	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HEC75_RS21605	COG1733	regulation of RNA biosynthetic process
HEC75_RS21610	COG0702	epimerase
HEC75_RS21615	COG0697	spore germination
HEC75_RS21625	COG1113	amino acid transport
HEC75_RS21630	COG0545	Peptidyl-prolyl cis-trans isomerase
HEC75_RS21635	COG3061	Opacity-associated protein A
HEC75_RS21650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEC75_RS21715	COG1073	alpha beta
HEC75_RS21720	COG3650	response to hydrogen peroxide
HEC75_RS21730	COG1960	acyl-CoA dehydrogenase activity
HEC75_RS21735	COG0754	glutathionylspermidine amidase activity
HEC75_RS21740	COG5463	Belongs to the UPF0441 family
HEC75_RS21745	COG3766	membrane
HEC75_RS21755	COG1842	Phage shock protein A
HEC75_RS21760	COG3789	protein conserved in bacteria
HEC75_RS21770	COG0557	exoribonuclease II activity
HEC75_RS21785	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HEC75_RS21790	COG0330	HflC and HflK could
HEC75_RS21795	COG0330	HflC and HflK could
HEC75_RS21800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEC75_RS21825	COG0802	atpase or kinase
HEC75_RS21830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEC75_RS21830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEC75_RS21850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC75_RS21870	COG1511	domain protein
HEC75_RS21870	COG3264	Mechanosensitive ion channel
HEC75_RS21890	COG1053	succinate dehydrogenase
HEC75_RS21895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEC75_RS21925	COG5510	response to toxic substance
HEC75_RS21965	COG0531	amino acid
HEC75_RS21970	COG3030	protein affecting phage T7 exclusion by the F plasmid
HEC75_RS21975	COG1027	Aspartate ammonia-lyase
HEC75_RS21980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC75_RS21995	COG1309	transcriptional regulator
HEC75_RS22010	COG0671	phosphoesterase, PA-phosphatase related
HEC75_RS22040	COG2197	response regulator
HEC75_RS22065	COG3381	protein complex oligomerization
HEC75_RS22070	COG3302	dmso reductase anchor subunit
HEC75_RS22075	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS22080	COG0243	molybdopterin cofactor binding
HEC75_RS22085	COG3290	protein histidine kinase activity
HEC75_RS22090	COG4565	transcriptional regulatory protein
HEC75_RS22100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC75_RS22105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC75_RS22105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC75_RS22120	COG2169	Transcriptional regulator
HEC75_RS22125	COG1982	Orn Lys Arg decarboxylase major
HEC75_RS22130	COG2207	Transcriptional regulator
HEC75_RS22135	COG0531	amino acid
HEC75_RS22165	COG2824	Alkylphosphonate utilization operon protein PhnA
HEC75_RS22170	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HEC75_RS22190	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HEC75_RS22200	COG1301	dicarboxylic acid transport
HEC75_RS22205	COG4235	cytochrome complex assembly
HEC75_RS22210	COG3088	subunit of a heme lyase
HEC75_RS22215	COG1138	Cytochrome C-type biogenesis protein
HEC75_RS22220	COG3301	Polysulphide reductase, NrfD
HEC75_RS22225	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS22230	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HEC75_RS22240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEC75_RS22245	COG3162	membrane
HEC75_RS22255	COG1346	cytolysis
HEC75_RS22260	COG1380	Effector of murein hydrolase LrgA
HEC75_RS22265	COG0583	DNA-binding transcription factor activity
HEC75_RS22270	COG0025	NhaP-type Na H and K H
HEC75_RS22275	COG2252	PERMEase
HEC75_RS22295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HEC75_RS22355	COG2315	Protein conserved in bacteria
HEC75_RS22365	COG3700	Belongs to the class B bacterial acid phosphatase family
HEC75_RS22405	COG0735	belongs to the Fur family
HEC75_RS22420	COG0534	Mate efflux family protein
HEC75_RS22430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEC75_RS22475	COG3833	ABC-type maltose transport systems, permease component
HEC75_RS22485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC75_RS22510	COG0527	aspartate kinase activity
HEC75_RS22525	COG0561	phosphatase activity
HEC75_RS22530	COG1349	DNA-binding transcription factor activity
HEC75_RS22545	COG3122	Protein conserved in bacteria
HEC75_RS22590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEC75_RS22630	COG0151	Belongs to the GarS family
HEC75_RS22635	COG2204	response regulator
HEC75_RS22695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEC75_RS22700	COG2104	thiamine diphosphate biosynthetic process
HEC75_RS22760	COG0250	Participates in transcription elongation, termination and antitermination
HEC75_RS22810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEC75_RS22870	COG0583	DNA-binding transcription factor activity
HEC75_RS22910	COG2207	Transcriptional regulator
HEC75_RS22920	COG0371	Dehydrogenase
HEC75_RS22925	COG3738	Protein conserved in bacteria
HEC75_RS22945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEC75_RS22950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEC75_RS22955	COG0737	Belongs to the 5'-nucleotidase family
HEC75_RS22970	COG0668	transmembrane transport
HEC75_RS22975	COG0527	aspartate kinase activity
HEC75_RS22975	COG0460	homoserine dehydrogenase
HEC75_RS22980	COG0626	cystathionine gamma-synthase activity
HEC75_RS23005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEC75_RS23010	COG1609	Transcriptional regulator
HEC75_RS23015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEC75_RS23030	COG1575	Belongs to the MenA family. Type 1 subfamily
HEC75_RS23045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEC75_RS23055	COG1494	fructose-1,6-bisphosphatase
HEC75_RS23065	COG3152	Membrane
HEC75_RS23085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEC75_RS23100	COG2211	Major facilitator Superfamily
HEC75_RS23125	COG3678	ATP-independent chaperone mediated protein folding
HEC75_RS23130	COG0745	RESPONSE REGULATOR receiver
HEC75_RS23135	COG2205	protein histidine kinase activity
HEC75_RS23145	COG2258	MOSC domain
HEC75_RS23160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HEC75_RS23205	COG1454	alcohol dehydrogenase
HEC75_RS23220	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HEC75_RS23250	COG0437	4 iron, 4 sulfur cluster binding
HEC75_RS23255	COG2864	formate dehydrogenase
HEC75_RS23270	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HEC75_RS23280	COG4680	protein conserved in bacteria
HEC75_RS23285	COG5499	transcription regulator containing HTH domain
HEC75_RS23290	COG0456	acetyltransferase
HEC75_RS23305	COG1011	Hydrolase
HEC75_RS23310	COG1349	DNA-binding transcription factor activity
HEC75_RS23315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS23325	COG3684	Belongs to the aldolase LacD family
HEC75_RS23335	COG2017	converts alpha-aldose to the beta-anomer
HEC75_RS23340	COG1501	Belongs to the glycosyl hydrolase 31 family
HEC75_RS23385	COG0561	phosphatase activity
HEC75_RS23440	COG0204	Acyl-transferase
HEC75_RS23455	COG3084	Protein conserved in bacteria
HEC75_RS23465	COG1763	Mo-molybdopterin cofactor biosynthetic process
HEC75_RS23510	COG1739	Uncharacterized protein family UPF0029
HEC75_RS23540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEC75_RS23555	COG0805	protein transport
HEC75_RS23560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEC75_RS23600	COG0641	radical SAM
HEC75_RS23620	COG0561	phosphatase activity
HEC75_RS23625	COG2267	carboxylic ester hydrolase activity
HEC75_RS23630	COG1280	lysine exporter protein (LysE YggA)
HEC75_RS23635	COG1280	lysine exporter protein (LysE YggA)
HEC75_RS23680	COG1011	Hydrolase
HEC75_RS23685	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HEC75_RS23740	COG2959	enzyme of heme biosynthesis
HEC75_RS23745	COG3071	HemY protein
HEC75_RS23795	COG2244	polysaccharide biosynthetic process
HEC75_RS23800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEC75_RS23805	COG0456	acetyltransferase
HEC75_RS23810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEC75_RS23810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEC75_RS23815	COG1088	dTDP-glucose 4,6-dehydratase activity
HEC75_RS23820	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEC75_RS23850	COG3118	belongs to the thioredoxin family
HEC75_RS23920	COG3978	acetolactate synthase activity
HEC75_RS23980	COG2186	Transcriptional regulator
HEC75_RS23985	COG0477	Major facilitator Superfamily
HEC75_RS23990	COG1609	Transcriptional regulator
HEC75_RS23995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC75_RS24005	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC75_RS24040	COG1522	sequence-specific DNA binding
HEC75_RS24045	COG0716	FMN binding
HEC75_RS24060	COG3312	ion transport
HEC75_RS24120	COG4533	DNA binding
HEC75_RS24125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEC75_RS24130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC75_RS24130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC75_RS24130	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HEC75_RS24135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEC75_RS24140	COG0573	inorganic phosphate transmembrane transporter activity
HEC75_RS24145	COG0581	inorganic phosphate transmembrane transporter activity
HEC75_RS24155	COG0704	Plays a role in the regulation of phosphate uptake
HEC75_RS24160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC75_RS24165	COG2252	PERMEase
HEC75_RS24170	COG0431	NADPH-dependent FMN reductase
HEC75_RS24175	COG2091	lysine biosynthetic process via aminoadipic acid