locus-tag class description HEC78_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEC78_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC78_RS00030 ENOG4105CXK mandelate racemase muconate lactonizing HEC78_RS00035 ENOG4105DJB Major Facilitator Superfamily HEC78_RS00040 ENOG410667J hydrolase HEC78_RS00045 ENOG4105EMF GntR family transcriptional regulator HEC78_RS00050 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HEC78_RS00055 ENOG4108RTU Aldolase HEC78_RS00065 ENOG4105DJB Major Facilitator Superfamily HEC78_RS00070 ENOG4105BZU Histidine kinase HEC78_RS00075 ENOG4108SV3 Tmao reductase system periplasmic protein tort HEC78_RS00080 ENOG4106WF9 DNA-binding transcriptional regulator TorR HEC78_RS00085 ENOG4105CUW cytochrome C-TYPE protein HEC78_RS00090 ENOG4108EM1 reductase HEC78_RS00100 ENOG4105CA0 peroxidase HEC78_RS00135 ENOG4105DA4 cytochrome c-type biogenesis protein HEC78_RS00155 ENOG4105D99 atp gtp-binding protein HEC78_RS00160 ENOG4105R2A (LipO)protein HEC78_RS00180 ENOG4105VG5 Membrane HEC78_RS00185 ENOG4105JP4 Inner membrane protein yidG HEC78_RS00190 ENOG4105J13 transcriptional regulator HEC78_RS00205 ENOG4105W8I Transcriptional regulator HEC78_RS00215 ENOG4105E5M Multidrug resistance protein D HEC78_RS00240 ENOG4105C7K acetolactate synthase HEC78_RS00245 ENOG4105M71 acetolactate synthase 1 regulatory subunit HEC78_RS00250 ENOG4107FB0 transcriptional regulator DeoR family HEC78_RS00260 ENOG4105EDR glucose galactose transporter HEC78_RS00270 ENOG4108KX4 response regulator HEC78_RS00275 ENOG4105BZU Histidine kinase HEC78_RS00280 ENOG4105CXY transporter HEC78_RS00290 ENOG4108SAJ Protein of unknown function (DUF1198) HEC78_RS00305 ENOG41090UW PTS System HEC78_RS00310 ENOG4105DT3 PTS system, galactitol-specific IIc component HEC78_RS00320 ENOG4105D2N Aldolase HEC78_RS00345 ENOG4105CS2 ec 3.2.1.21 HEC78_RS00365 ENOG4105DAS pts system HEC78_RS00370 ENOG4105ETZ PTS System HEC78_RS00375 ENOG4105F3R pts system mannose fructose sorbose family iid HEC78_RS00390 ENOG4105DNE Transposase HEC78_RS00395 ENOG4108UZ3 Transporter HEC78_RS00405 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEC78_RS00420 ENOG4105CHJ isochorismatase hydrolase HEC78_RS00430 ENOG4108TC1 Transcriptional regulator HEC78_RS00435 ENOG4105FV3 HEC78_RS00445 ENOG4105ISV protein with bipartite regulator domain HEC78_RS00465 ENOG4107WZZ SMC domain protein HEC78_RS00485 ENOG4105CT4 transporter HEC78_RS00490 ENOG4105CJQ hydrolase, family 31 HEC78_RS00495 ENOG4105JV1 AsmA family HEC78_RS00500 ENOG4105C2W permease HEC78_RS00505 ENOG4105D6U Sodium Glutamate Symporter HEC78_RS00510 ENOG4105CB5 ATP-dependent DNA helicase recG HEC78_RS00515 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HEC78_RS00520 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEC78_RS00540 ENOG4105EN6 Membrane HEC78_RS00555 ENOG4105DSJ YicC domain protein HEC78_RS00560 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HEC78_RS00580 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HEC78_RS00610 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HEC78_RS00615 ENOG4105DKP glycosyl transferase, family 9 HEC78_RS00620 ENOG4107RJ7 Glycosyl transferase (Group 1 HEC78_RS00625 ENOG4107543 (lipo)polysaccharide HEC78_RS00630 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide HEC78_RS00635 ENOG4107XU6 Glycosyl transferase (Group 1 HEC78_RS00640 ENOG4106AH0 Glycosyl Transferase HEC78_RS00650 ENOG4108PDR lipopolysaccharide core biosynthesis protein HEC78_RS00655 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HEC78_RS00660 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HEC78_RS00665 ENOG4108FRV O-antigen ligase HEC78_RS00670 ENOG4105D16 lipopolysaccharide heptosyltransferase i HEC78_RS00675 ENOG4105XA0 heptosyltransferase ii HEC78_RS00685 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HEC78_RS00695 ENOG4105K64 Glycosyl transferase, family 2 HEC78_RS00700 ENOG4105PXI polysaccharide deacetylase HEC78_RS00705 ENOG41063SB peptidase HEC78_RS00715 ENOG4107YZP Rhodanese domain protein HEC78_RS00720 ENOG4105VW4 glutaredoxin 3 HEC78_RS00725 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HEC78_RS00730 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEC78_RS00735 ENOG4105D7W serine acetyltransferase HEC78_RS00740 ENOG4105DJB Major Facilitator Superfamily HEC78_RS00745 ENOG4105DIA mandelate racemase muconate lactonizing HEC78_RS00750 ENOG4105ETE Transcriptional regulator (LacI family HEC78_RS00755 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HEC78_RS00765 ENOG41073TP transcriptional regulator HEC78_RS00770 ENOG4105DAA L-lactate HEC78_RS00775 ENOG4105EUR Domain-Containing protein HEC78_RS00780 ENOG4108WY4 inner membrane lipoprotein HEC78_RS00785 ENOG4108YYI Protein of unknown function (DUF2810) HEC78_RS00795 ENOG4105E61 Mannitol repressor protein HEC78_RS00800 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HEC78_RS00805 ENOG4105CTS PTS system mannitol-specific HEC78_RS00810 ENOG4108U78 Glutathione S-transferase HEC78_RS00820 ENOG4105EM7 Selenocysteine-specific translation elongation factor HEC78_RS00825 ENOG41066F8 ROK family HEC78_RS00830 ENOG4105C26 Dehydrogenase HEC78_RS00845 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HEC78_RS00850 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HEC78_RS00855 ENOG4105H6Q decarboxylase HEC78_RS00860 ENOG4105CMG Carbohydrate kinase HEC78_RS00865 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HEC78_RS00870 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HEC78_RS00875 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HEC78_RS00880 ENOG4108M5W HEC78_RS00885 ENOG4108R66 Conserved Protein HEC78_RS00890 ENOG4105DG4 malate L-lactate dehydrogenase HEC78_RS00895 ENOG4105J4Q Transcriptional regulator HEC78_RS00900 ENOG4108XIB electron transport protein ysaA HEC78_RS00905 ENOG4105JKW Valine--pyruvate aminotransferase HEC78_RS00910 ENOG4107T9C Alpha amylase catalytic region HEC78_RS00915 ENOG4108UR8 BAX protein HEC78_RS00920 ENOG4105T16 Transcriptional regulator (AraC family) HEC78_RS00925 ENOG4105C93 Xylose Isomerase HEC78_RS00930 ENOG4105CMG Carbohydrate kinase HEC78_RS00935 ENOG410688U Inner membrane protein yiaB HEC78_RS00940 ENOG4105MEV Acyl-transferase HEC78_RS00960 ENOG4108RS6 transposase HEC78_RS00975 ENOG4105MVF Transcriptional regulator HEC78_RS00980 ENOG4106JH6 (LipO)protein HEC78_RS00990 ENOG4108ZG0 Ompa motb domain protein HEC78_RS00995 ENOG4107QY8 reductase HEC78_RS01000 ENOG4105HNP -acetyltransferase HEC78_RS01005 ENOG4108R3E Dna-3-methyladenine glycosylase i HEC78_RS01010 ENOG4105EAX Putative lipase HEC78_RS01015 ENOG4105DIJ Phosphoethanolamine transferase HEC78_RS01030 ENOG4108RS6 transposase HEC78_RS01040 ENOG4105CQ4 Transcriptional regulator HEC78_RS01055 ENOG4105DEF Extracellular solute-binding protein, family 5 HEC78_RS01060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC78_RS01065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEC78_RS01070 ENOG4105C3U ABC transporter HEC78_RS01075 ENOG4108JQ7 (ABC) transporter HEC78_RS01080 ENOG4105C44 Serine transporter HEC78_RS01095 ENOG4105D1V cellulose synthase operon protein YhjU HEC78_RS01100 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HEC78_RS01110 ENOG410661M cytoplasmic protein HEC78_RS01115 ENOG4105UTS cellulose synthase operon protein YhjQ HEC78_RS01120 ENOG4107QZ7 Cellulose synthase catalytic subunit HEC78_RS01125 ENOG4107EEX Cellulose synthase regulator protein HEC78_RS01130 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HEC78_RS01135 ENOG4105EJG cellulose synthase HEC78_RS01140 ENOG4105BZU Histidine kinase HEC78_RS01150 ENOG4105CS0 peptidase HEC78_RS01155 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HEC78_RS01160 ENOG4105CMB EAL domain-containing protein HEC78_RS01165 ENOG41066T0 asmA family HEC78_RS01170 ENOG4105CSH Transporter HEC78_RS01175 ENOG4107H3J ribonuclease HEC78_RS01180 ENOG4105CBN LysR family transcriptional regulator HEC78_RS01185 ENOG4106S2D Transcriptional regulator HEC78_RS01205 ENOG4105FDP GntR family transcriptional regulator HEC78_RS01210 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HEC78_RS01215 ENOG4108KPW sugar kinase HEC78_RS01220 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HEC78_RS01230 ENOG4105DC8 reductase HEC78_RS01235 ENOG4105D6S protein involved in catabolism of external DNA HEC78_RS01240 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEC78_RS01245 ENOG4105DGW oligopeptidase A HEC78_RS01255 ENOG4105DUX Transporter HEC78_RS01260 ENOG4108M6U Universal stress protein A HEC78_RS01270 ENOG4105CJ3 phosphate transporter HEC78_RS01275 ENOG4105CBX hi0933 family HEC78_RS01280 ENOG4105D0S secretion protein (HlyD HEC78_RS01285 ENOG4105CJ1 ABC, transporter HEC78_RS01290 ENOG4105CMI transporter HEC78_RS01300 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HEC78_RS01305 ENOG4105DSF transport protein HEC78_RS01315 ENOG4108W1V Lipoprotein HEC78_RS01320 ENOG4105EX9 Membrane HEC78_RS01330 ENOG4105C8Q Methyl-accepting chemotaxis HEC78_RS01340 ENOG4107FS9 Membrane HEC78_RS01350 ENOG4105MG3 Membrane HEC78_RS01355 ENOG4106H78 methyltransferase HEC78_RS01360 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HEC78_RS01365 ENOG4105CAK Cell division ATP-binding protein ftsE HEC78_RS01370 ENOG4105CRP Part of the ABC transporter FtsEX involved in HEC78_RS01380 ENOG4105CP9 extracellular ligand-binding receptor HEC78_RS01390 ENOG4105U59 -acetyltransferase HEC78_RS01395 ENOG4105CP9 extracellular ligand-binding receptor HEC78_RS01400 ENOG4105C32 Amino acid ABC transporter (Permease) HEC78_RS01405 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HEC78_RS01410 ENOG4105C0Z ABC transporter HEC78_RS01415 ENOG4108IV0 ABC, transporter HEC78_RS01425 ENOG4105BZ7 extracellular solute-binding protein family 1 HEC78_RS01440 ENOG4108IJ9 (ABC) transporter HEC78_RS01445 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HEC78_RS01450 ENOG4105WC8 Conserved Protein HEC78_RS01455 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HEC78_RS01460 ENOG41080QX K07048 phosphotriesterase-related protein HEC78_RS01475 ENOG4108RVA ribokinase HEC78_RS01480 ENOG4105WCN acetyltransferase HEC78_RS01485 ENOG4105D9R oxidoreductase HEC78_RS01490 ENOG4105C2I pirin domain protein HEC78_RS01495 ENOG4105DIQ Transcriptional regulator HEC78_RS01500 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEC78_RS01505 ENOG4105C6Z Gluconate HEC78_RS01515 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HEC78_RS01520 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HEC78_RS01540 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEC78_RS01545 ENOG4107HP6 Transcriptional regulator HEC78_RS01550 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEC78_RS01555 ENOG4105C01 Dihydroxy-acid dehydratase HEC78_RS01565 ENOG4105DCT glycerol dehydrogenase HEC78_RS01580 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HEC78_RS01595 ENOG4105E98 transcriptional regulator DeoR family HEC78_RS01605 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEC78_RS01610 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HEC78_RS01615 ENOG4105C6Z Gluconate HEC78_RS01625 ENOG4105MJ2 Competence protein HEC78_RS01635 ENOG4105DNE Transposase HEC78_RS01650 ENOG4105XFK Ferrous iron transport protein A HEC78_RS01655 ENOG4105BZM domain protein HEC78_RS01660 ENOG4108RRZ Transcription elongation factor GreB HEC78_RS01670 ENOG4105E0F Histidine kinase HEC78_RS01680 ENOG4108MAJ Membrane HEC78_RS01690 ENOG4105VEJ Heat shock protein HEC78_RS01695 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HEC78_RS01705 ENOG4107RK2 ADP-ribose diphosphatase NudE HEC78_RS01710 ENOG4108JQC penicillin-binding protein 1A HEC78_RS01715 ENOG4108U1Q Pilus assembly protein HEC78_RS01720 ENOG41065NF Fimbrial assembly family protein HEC78_RS01725 ENOG4105XPX DNA utilization protein HofO HEC78_RS01730 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HEC78_RS01735 ENOG4105E4G Type IV pilus HEC78_RS01750 ENOG4105EGB membrane protein DamX HEC78_RS01755 ENOG4105DFE Dna adenine methylase HEC78_RS01760 ENOG4105DJV ribulose-phosphate 3-epimerase HEC78_RS01770 ENOG4105C31 Tryptophanyl-tRNA synthetase HEC78_RS01775 ENOG4105VYH HEC78_RS01780 ENOG4107EF2 surface-exposed virulence protein HEC78_RS01785 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HEC78_RS01790 ENOG4107V9H nitrite transporter HEC78_RS01795 ENOG4105WZK nitrite reductase NADPH small subunit HEC78_RS01800 ENOG4107QZF nitrite reductase NADPH large subunit HEC78_RS01810 ENOG4106DTQ Protein TsgA homolog HEC78_RS01815 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HEC78_RS01820 ENOG4106195 uncharacterized protein yhfG HEC78_RS01825 ENOG4105MZU cell filamentation protein HEC78_RS01830 ENOG4105DDQ anthranilate synthase HEC78_RS01835 ENOG4105C8Y Acetylornithine aminotransferase HEC78_RS01840 ENOG410613R integral membrane protein, YccS YhfK family HEC78_RS01845 ENOG4107RYR Transcriptional regulator, Crp Fnr family HEC78_RS01850 ENOG4108UKZ OsmC family HEC78_RS01855 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HEC78_RS01865 ENOG4105DNZ Alpha Beta Hydrolase HEC78_RS01870 ENOG4105N0V mono-oxygenase ydhR HEC78_RS01875 ENOG4108K70 Transcriptional regulator HEC78_RS01880 ENOG4105C5H ABC transporter HEC78_RS01895 ENOG4105VKU nucleicacid-binding protein HEC78_RS01900 ENOG4108YZY peptidylprolyl cis-trans isomerase HEC78_RS01905 ENOG4105VRX Protein slyX homolog HEC78_RS01910 ENOG4108V1T peptidylprolyl cis-trans isomerase HEC78_RS01915 ENOG4105WWK YheO domain protein HEC78_RS01940 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HEC78_RS01950 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEC78_RS01955 ENOG4105W53 bacterioferritin-associated ferredoxin HEC78_RS01960 ENOG4108UQY Iron-storage protein HEC78_RS01965 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HEC78_RS01995 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HEC78_RS02015 ENOG41083MP 50s ribosomal protein l29 HEC78_RS02020 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HEC78_RS02030 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HEC78_RS02055 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HEC78_RS02065 ENOG4105VPB 50S ribosomal protein L30 HEC78_RS02075 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HEC78_RS02080 ENOG41067V7 50S ribosomal protein L36 HEC78_RS02095 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HEC78_RS02110 ENOG4105VTS DnaJ-like, subfamily C HEC78_RS02115 ENOG4105W1Y Transcriptional regulator HEC78_RS02120 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HEC78_RS02125 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HEC78_RS02130 ENOG4105C1A potassium transporter peripheral membrane HEC78_RS02150 ENOG4105C79 DNA protecting protein DprA HEC78_RS02160 ENOG4108WI1 Dna topoisomerase HEC78_RS02175 ENOG4105SG3 Protein of unknown function (DUF1488) HEC78_RS02180 ENOG4108Z0R Transferase HEC78_RS02220 ENOG4105XCM membrane LIPOPROTEIN HEC78_RS02225 ENOG4105BZS acriflavin resistance protein HEC78_RS02230 ENOG4105C1P efflux transporter, rnd family, mfp subunit HEC78_RS02235 ENOG4108XG4 DNA-binding transcriptional regulator HEC78_RS02240 ENOG4105BZU Histidine kinase HEC78_RS02245 ENOG41061ME transport protein HEC78_RS02250 ENOG4105CEC DNA methylase N-4 N-6 HEC78_RS02260 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HEC78_RS02275 ENOG4108IA2 Sodium pantothenate symporter HEC78_RS02280 ENOG4105RG0 Membrane HEC78_RS02285 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HEC78_RS02290 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HEC78_RS02305 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HEC78_RS02310 ENOG41062P1 Diguanylate cyclase phosphodiesterase HEC78_RS02320 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HEC78_RS02325 ENOG4105VQ7 Rod shape-determining protein MreD HEC78_RS02335 ENOG4105C03 ribonuclease HEC78_RS02340 ENOG4105QD6 exported protein HEC78_RS02345 ENOG4105D1U peptidase U62 modulator of DNA gyrase HEC78_RS02350 ENOG4105CR8 Transcriptional regulator HEC78_RS02355 ENOG4105ZQC membrane protein AaeX HEC78_RS02370 ENOG4108RS6 transposase HEC78_RS02375 ENOG4105UNR (Barnase) inhibitor HEC78_RS02380 ENOG4105RID UPF0379 protein yhcN HEC78_RS02385 ENOG4105RID UPF0379 protein yhcN HEC78_RS02410 ENOG4105C8P )-transporter HEC78_RS02415 ENOG4106DSS Tartrate dehydratase subunit alpha HEC78_RS02420 ENOG4107GFK fumarate HEC78_RS02430 ENOG4107QSA Oxaloacetate decarboxylase HEC78_RS02435 ENOG4105D9Q decarboxylase (Beta subunit) HEC78_RS02450 ENOG4105C0H protease HEC78_RS02455 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HEC78_RS02460 ENOG4105D6Z AFG1 family ATPase HEC78_RS02480 ENOG4107MKT Stringent starvation protein a HEC78_RS02485 ENOG4105KB2 stringent starvation protein b HEC78_RS02515 ENOG4108R66 Conserved Protein HEC78_RS02520 ENOG4105DZC cytosine deaminase HEC78_RS02525 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HEC78_RS02530 ENOG4105DFS Conserved Protein HEC78_RS02535 ENOG4105BZ8 glutamate synthase HEC78_RS02540 ENOG4105CBC glutamate synthase HEC78_RS02545 ENOG4105N5T Radical SAM Protein HEC78_RS02550 ENOG4105BZU Histidine kinase HEC78_RS02555 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HEC78_RS02565 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HEC78_RS02570 ENOG41080Z8 PHOSPHOCARRIER protein HEC78_RS02580 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HEC78_RS02585 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HEC78_RS02590 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC78_RS02595 ENOG4108IUZ ABC transporter HEC78_RS02600 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HEC78_RS02605 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HEC78_RS02610 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HEC78_RS02615 ENOG4105C2X Arabinose 5-phosphate isomerase HEC78_RS02620 ENOG4105FEU K -dependent Na -Ca exchanger HEC78_RS02625 ENOG4105DHJ ABC, transporter HEC78_RS02630 ENOG4105CY3 ABC transporter, permease HEC78_RS02635 ENOG4107PE3 Mammalian cell entry related domain protein HEC78_RS02640 ENOG4105E3I toluene tolerance HEC78_RS02645 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HEC78_RS02650 ENOG4105VFK BolA family HEC78_RS02660 ENOG4105HVQ Regulatory factor of maltose metabolism HEC78_RS02665 ENOG4105EAH synthase HEC78_RS02675 ENOG4105K46 50S ribosomal protein l27 HEC78_RS02680 ENOG4105QYV Membrane HEC78_RS02690 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HEC78_RS02695 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEC78_RS02700 ENOG4105HBR Rna-binding protein HEC78_RS02710 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEC78_RS02715 ENOG4105EEI dihydropteroate synthase HEC78_RS02725 ENOG4105NTZ Preprotein translocase subunit SecG HEC78_RS02750 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HEC78_RS02755 ENOG4105CHV Transcription elongation factor NusA HEC78_RS02795 ENOG4105C1J atp-dependent rna helicase HEC78_RS02800 ENOG4105CIC tryptophan-specific transport protein HEC78_RS02810 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HEC78_RS02815 ENOG4105DEN Luciferase family HEC78_RS02835 ENOG4108YYD acetyltransferase HEC78_RS02850 ENOG4107R7Y intracellular protease Pfpi family HEC78_RS02855 ENOG4105K4T epimerase HEC78_RS02860 ENOG4105W4M Transport-associated protein HEC78_RS02875 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HEC78_RS02880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HEC78_RS02890 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HEC78_RS02895 ENOG4105DT3 PTS system, galactitol-specific IIc component HEC78_RS02900 ENOG41090UW PTS System HEC78_RS02905 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HEC78_RS02920 ENOG4105CTX dehydratase HEC78_RS02930 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEC78_RS02935 ENOG4105BZW Glycerate kinase HEC78_RS02945 ENOG410811B TRANSCRIPTIONal HEC78_RS02950 ENOG4105C7B Threonine dehydratase HEC78_RS02960 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEC78_RS02965 ENOG4105C6N Formate acetyltransferase HEC78_RS02970 ENOG4105EJQ L-serine dehydratase HEC78_RS02975 ENOG4105C44 Serine transporter HEC78_RS02985 ENOG4106D80 Uncharacterized protein YhaL HEC78_RS02990 ENOG4108CNN domain protein HEC78_RS02995 ENOG4105CWB LysR family transcriptional Regulator HEC78_RS03000 ENOG4105KAF membrAne HEC78_RS03005 ENOG4105CHF Glutathione S-transferase HEC78_RS03010 ENOG4108VBZ doxx family HEC78_RS03015 ENOG4105YJD HEC78_RS03020 ENOG41090KG Inner membrane protein YqjE HEC78_RS03025 ENOG4105NE1 Conserved Protein HEC78_RS03030 ENOG4105WAY exported protein HEC78_RS03040 ENOG4106W5V Membrane HEC78_RS03050 ENOG4105DU1 integral membrane protein, terc HEC78_RS03055 ENOG4105EE0 oxidoreductase HEC78_RS03060 ENOG4108UB4 uncharacterized protein ygjQ HEC78_RS03065 ENOG4108VKG metal-dependent hydrolase HEC78_RS03075 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEC78_RS03085 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HEC78_RS03095 ENOG4105C8Q Methyl-accepting chemotaxis HEC78_RS03100 ENOG4105NTW Transcriptional regulator HEC78_RS03105 ENOG4105Q26 Siderophore-interacting protein HEC78_RS03110 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC78_RS03125 ENOG4105MEH HEC78_RS03155 ENOG4108IRC dna polymerase iii HEC78_RS03165 ENOG4105DFE Dna adenine methylase HEC78_RS03170 ENOG4105VZ1 Replication Protein HEC78_RS03185 ENOG4105ED4 portal protein HEC78_RS03280 ENOG4108X9F tail fiber protein HEC78_RS03315 ENOG4108VCA G U mismatch-specific DNA glycosylase HEC78_RS03320 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC78_RS03325 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HEC78_RS03355 ENOG4107ZVW dihydroneopterin aldolase HEC78_RS03370 ENOG4106MWK domain protein HEC78_RS03375 ENOG4105I7R Adenylate cyclase HEC78_RS03395 ENOG4107S78 Band 7 protein HEC78_RS03400 ENOG4105PV3 Inner membrane protein yqiJ HEC78_RS03410 ENOG4105W0Z cytoplasmic protein HEC78_RS03420 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) HEC78_RS03430 ENOG4108MR7 Arylsulfotransferase HEC78_RS03440 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HEC78_RS03445 ENOG4106032 Glutathionylspermidine synthase HEC78_RS03450 ENOG4105F1G UPF0441 protein HEC78_RS03460 ENOG41087AY ADP-Ribose pyrophosphatase HEC78_RS03465 ENOG4108SX3 cytoplasmic protein HEC78_RS03470 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HEC78_RS03475 ENOG4105IPS esterase HEC78_RS03480 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC78_RS03485 ENOG4105VRH Antibiotic biosynthesis monooxygenase HEC78_RS03490 ENOG4105NF4 modulator of drug activity HEC78_RS03495 ENOG4105DHQ Histidine kinase HEC78_RS03500 ENOG4105XJC Two component transcriptional regulator (Winged helix family HEC78_RS03505 ENOG4105H4F exported protein HEC78_RS03510 ENOG4105F4I Transcriptional regulator HEC78_RS03515 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC78_RS03520 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HEC78_RS03525 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HEC78_RS03550 ENOG4105CCT upf0313 protein HEC78_RS03560 ENOG4107QPK )-transporter HEC78_RS03565 ENOG4105CV8 reductase HEC78_RS03570 ENOG4108I6A alcohol dehydrogenase HEC78_RS03575 ENOG4105CF7 AraC family transcriptional regulator HEC78_RS03580 ENOG4108K81 inner membrane protein YghB HEC78_RS03585 ENOG4105C28 cystathionine HEC78_RS03590 ENOG4105CWK Biopolymer transport protein, ExbB HEC78_RS03595 ENOG4108ZZF transport protein (ExbD) HEC78_RS03600 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEC78_RS03625 ENOG4105C8Q Methyl-accepting chemotaxis HEC78_RS03630 ENOG410900S Protein of unknown function (DUF2623) HEC78_RS03635 ENOG4105E3S small subunit HEC78_RS03640 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC78_RS03645 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HEC78_RS03650 ENOG4105DPX Hydrogenase, large subunit HEC78_RS03655 ENOG4108USZ hydrogenase HEC78_RS03660 ENOG4108WGS hydrogenase 2-specific chaperone HEC78_RS03665 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HEC78_RS03670 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HEC78_RS03675 ENOG4105S10 periplasmic binding protein HEC78_RS03680 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HEC78_RS03685 ENOG4105CYM Glutathione S-transferase HEC78_RS03690 ENOG4106032 Glutathionylspermidine synthase HEC78_RS03705 ENOG4105DEI Mannitol dehydrogenase HEC78_RS03715 ENOG4105DPW Major facilitator superfamily MFS_1 HEC78_RS03740 ENOG4105C26 Dehydrogenase HEC78_RS03745 ENOG4105CJP fad dependent oxidoreductase HEC78_RS03755 ENOG4105CUB amino acid HEC78_RS03765 ENOG4108UAJ Transcriptional regulator HEC78_RS03770 ENOG4105E3J oxidoreductase HEC78_RS03775 ENOG41066GK UPF0379 protein ykgI HEC78_RS03795 ENOG4108UQV Membrane HEC78_RS03800 ENOG4105CXN decarboxylase HEC78_RS03805 ENOG4105EAA nucleoside HEC78_RS03815 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HEC78_RS03820 ENOG4105CEN a g-specific adenine glycosylase HEC78_RS03830 ENOG41090ED Protein with unknown function (DUF469) HEC78_RS03835 ENOG4105K33 Periplasmic Protein HEC78_RS03840 ENOG4105HDK L-asparaginase HEC78_RS03845 ENOG4106MH3 alpha helix chain HEC78_RS03850 ENOG4105CSA Coproporphyrinogen iii oxidase HEC78_RS03855 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HEC78_RS03865 ENOG4108VIA integral membrane protein HEC78_RS03870 ENOG4105DFA alanine racemase domain protein HEC78_RS03875 ENOG4105CZX twitching motility protein HEC78_RS03895 ENOG4105D7Z glutathione synthase HEC78_RS03900 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HEC78_RS03905 ENOG4105RWS endonuclease I HEC78_RS03940 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HEC78_RS03950 ENOG4108K0D peptidase, M48 HEC78_RS03955 ENOG4105CV1 Transketolase (EC 2.2.1.1) HEC78_RS03960 ENOG4108JJB ABC transporter HEC78_RS03965 ENOG4108JJB ABC transporter HEC78_RS03990 ENOG4105BZA Phosphoglycerate kinase HEC78_RS03995 ENOG4105D2N Aldolase HEC78_RS04000 ENOG4105D64 Mechanosensitive ion channel HEC78_RS04010 ENOG4105MPN Membrane HEC78_RS04030 ENOG4108JQ1 Dehydrogenase HEC78_RS04035 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HEC78_RS04055 ENOG4107RAQ aminopeptidase HEC78_RS04060 ENOG4105D0A hydroxylase HEC78_RS04065 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HEC78_RS04090 ENOG4105CS2 ec 3.2.1.21 HEC78_RS04100 ENOG4108UT2 hemolysin iii HEC78_RS04120 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HEC78_RS04125 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HEC78_RS04130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC78_RS04135 ENOG4105T95 Thiol disulfide interChange protein HEC78_RS04140 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HEC78_RS04160 ENOG4108K5P (LipO)protein HEC78_RS04180 ENOG4105VGJ Virulence-associated protein HEC78_RS04185 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HEC78_RS04190 ENOG4108T1M outer membrane protein x HEC78_RS04210 ENOG4106P2F Pfam:Pili_assembly_C HEC78_RS04240 ENOG4108MHD transport protein HEC78_RS04250 ENOG4105C5Q Transcriptional regulator HEC78_RS04255 ENOG4105CHU acetyl-coa acetyltransferase HEC78_RS04265 ENOG4105CHR reductase HEC78_RS04270 ENOG4107QNK )-transporter HEC78_RS04280 ENOG4105RQF LysR family Transcriptional regulator HEC78_RS04290 ENOG4105DDV Transcriptional regulator (LacI family HEC78_RS04310 ENOG4105CPC Aldo Keto reductase HEC78_RS04315 ENOG4105SUV lipoprotein YgdR HEC78_RS04320 ENOG4105EE5 Membrane protein terC HEC78_RS04335 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HEC78_RS04350 ENOG4105IPU prepilin peptidase dependent protein A HEC78_RS04355 ENOG4105JCS prepilin peptidase dependent protein HEC78_RS04360 ENOG4105SEN Protein of unknown function (DUF2509) HEC78_RS04365 ENOG4105RVB Prepilin peptidase dependent protein c HEC78_RS04370 ENOG4105DSY exodeoxyribonuclease V, gamma HEC78_RS04375 ENOG4107QXK peptidase HEC78_RS04380 ENOG4107QKA exodeoxyribonuclease V beta HEC78_RS04385 ENOG4107QYX exodeoxyribonuclease v alpha HEC78_RS04390 ENOG4108EKC n-acetylglutamate synthase HEC78_RS04395 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HEC78_RS04410 ENOG4105CA3 membrane-bound lytic murein transglycosylase HEC78_RS04415 ENOG4105CUZ uba thif-type nad fad binding protein HEC78_RS04420 ENOG4105FR1 rard protein HEC78_RS04425 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HEC78_RS04430 ENOG4105C9B Cysteine desulfurase HEC78_RS04435 ENOG4105M5B (LipO)protein HEC78_RS04440 ENOG4105ETT transcriptional Regulator, LysR family HEC78_RS04445 ENOG4105M08 Membrane HEC78_RS04455 ENOG4107EDW L-fucose operon activator HEC78_RS04465 ENOG4105CMG Carbohydrate kinase HEC78_RS04475 ENOG4105EDR glucose galactose transporter HEC78_RS04480 ENOG4107W7X Aldolase HEC78_RS04485 ENOG4105C0A alcohol dehydrogenase HEC78_RS04495 ENOG4105EJQ L-serine dehydratase HEC78_RS04500 ENOG4105C44 Serine transporter HEC78_RS04505 ENOG4105EWT decarboxylase family HEC78_RS04530 ENOG4105DR9 pseudouridine synthase HEC78_RS04535 ENOG4105QDK Flavodoxin HEC78_RS04545 ENOG4105DJB Major Facilitator Superfamily HEC78_RS04550 ENOG4105EQX glucarate dehydratase HEC78_RS04555 ENOG4105EQX glucarate dehydratase HEC78_RS04560 ENOG4105BZW Glycerate kinase HEC78_RS04565 ENOG4105BZU Histidine kinase HEC78_RS04570 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HEC78_RS04575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEC78_RS04580 ENOG4105X54 addiction module antidote protein HEC78_RS04610 ENOG4105NEV Fimbrial HEC78_RS04615 ENOG4108FZ9 Chaperone HEC78_RS04620 ENOG4106PG1 outer membrane usher protein HEC78_RS04630 ENOG4105DXN mazG family HEC78_RS04640 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HEC78_RS04645 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HEC78_RS04650 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEC78_RS04655 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HEC78_RS04670 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HEC78_RS04680 ENOG4105DTT CRISPR-associated helicase, cas3 HEC78_RS04695 ENOG41060M0 Crispr-associated protein, cse4 family HEC78_RS04700 ENOG4108VWQ crispr-associated protein HEC78_RS04710 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HEC78_RS04715 ENOG4105PWE CRISPR-associated protein cas2 HEC78_RS04720 ENOG4108MXK alkaline phosphatase isozyme conversion HEC78_RS04740 ENOG4105N0Z inner membrane protein ygbE HEC78_RS04775 ENOG4108K5P (LipO)protein HEC78_RS04785 ENOG4105KZM cytoplasmic protein HEC78_RS04790 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEC78_RS04795 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEC78_RS04805 ENOG4105MVE transcriptional regulator HEC78_RS04815 ENOG4105G63 Type III effector Hrp-dependent HEC78_RS04825 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HEC78_RS04830 ENOG4105EXW epimerase dehydratase HEC78_RS04835 ENOG4105C6Z Gluconate HEC78_RS04840 ENOG4105JQN Transcriptional regulator HEC78_RS04845 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC78_RS04880 ENOG4105MEW serine threonine protein phosphatase HEC78_RS04925 ENOG41090HZ type iii secretion HEC78_RS04935 ENOG4108N8R Invasion protein HEC78_RS04940 ENOG4108HR8 type iii secretion HEC78_RS04945 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone HEC78_RS04950 ENOG4108JIR Flagellum-specific ATP synthase HEC78_RS04955 ENOG41077MC Secretory protein (Associated with virulence) HEC78_RS04960 ENOG41078G4 surface presentation of HEC78_RS04965 ENOG4105T85 surface presentation of antigens protein HEC78_RS04970 ENOG41075IY surface presentation of antigens protein SpaP HEC78_RS04975 ENOG4105U07 type iii secretion HEC78_RS04980 ENOG4108TN6 type iii secretion HEC78_RS04985 ENOG4108M6W surface presentation of antigens protein SpaS HEC78_RS04995 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE HEC78_RS05005 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HEC78_RS05010 ENOG4105MH6 Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates SipC activity HEC78_RS05015 ENOG41079WB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEC78_RS05030 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear HEC78_RS05040 ENOG4108YAB Invasion protein HEC78_RS05050 ENOG4108RC9 Type III secretion system protein HEC78_RS05055 ENOG4105Y7Q type iii secretion HEC78_RS05060 ENOG4106BTR HEC78_RS05065 ENOG4108RBT type iii secretion HEC78_RS05095 ENOG4105CC5 ABC transporter HEC78_RS05100 ENOG4105CC5 ABC transporter HEC78_RS05105 ENOG4105DIK (ABC) transporter HEC78_RS05115 ENOG4105VXR cytoplasmic protein HEC78_RS05125 ENOG4105C45 hydrogenase expression formation protein (HypE) HEC78_RS05130 ENOG4105CQS hydrogenase expression formation protein HypD HEC78_RS05135 ENOG41083WG hydrogenase assembly chaperone HEC78_RS05140 ENOG4107RSS Hydrogenase accessory protein HypB HEC78_RS05145 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HEC78_RS05150 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HEC78_RS05155 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HEC78_RS05160 ENOG4107R30 NADH dehydrogenase HEC78_RS05165 ENOG4107TDF Formate hydrogenlyase subunit 4 HEC78_RS05170 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC78_RS05175 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HEC78_RS05180 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HEC78_RS05185 ENOG4105I6X formate hydrogenlyase maturation HEC78_RS05190 ENOG4108MG9 hydrogenase 3 maturation protease HEC78_RS05200 ENOG4108RC0 Electron transport protein HEC78_RS05205 ENOG4105C8H hydrogenase maturation protein Hypf HEC78_RS05225 ENOG4105C2X Arabinose 5-phosphate isomerase HEC78_RS05230 ENOG410804X Transcriptional regulator HEC78_RS05235 ENOG4105J92 DNA-binding transcriptional activator GutM HEC78_RS05240 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HEC78_RS05245 ENOG4105VI0 Pts system, glucitol sorbitol-specific HEC78_RS05250 ENOG4105DZY Pts system, glucitol sorbitol-specific HEC78_RS05255 ENOG410787A Pts system, glucitol sorbitol-specific HEC78_RS05260 ENOG4105CVE Lytic murein transglycosylase HEC78_RS05265 ENOG4107TH8 cina domain protein HEC78_RS05280 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HEC78_RS05285 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HEC78_RS05315 ENOG4107VXZ Hydrolase HEC78_RS05320 ENOG4105W39 Membrane HEC78_RS05340 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC78_RS05345 ENOG4105CW7 secretion protein, HlyD family HEC78_RS05350 ENOG4105NTK Transcriptional repressor Mpra HEC78_RS05360 ENOG4105GIJ Glycine betaine HEC78_RS05365 ENOG4108HQS Glycine betaine HEC78_RS05370 ENOG4108IJ7 Glycine betaine HEC78_RS05375 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC78_RS05380 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC78_RS05390 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HEC78_RS05395 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEC78_RS05405 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HEC78_RS05410 ENOG4108WMJ Protein of unknown function (DUF2002) HEC78_RS05415 ENOG4108RNS Exports L-alanine (By similarity) HEC78_RS05420 ENOG4108X73 DNA- binding protein HEC78_RS05430 ENOG4108V62 Rhodanese domain protein HEC78_RS05435 ENOG41080HT Transcriptional regulator, arsr family HEC78_RS05440 ENOG4105VPI YqaE family transport protein HEC78_RS05445 ENOG4109066 lysm domain bon superfamily protein HEC78_RS05450 ENOG4108PVQ transcriptional regulator HEC78_RS05455 ENOG4105C85 amino acid HEC78_RS05460 ENOG4108JPW Aminotransferase HEC78_RS05465 ENOG4105C26 Dehydrogenase HEC78_RS05470 ENOG4105D5U fad dependent oxidoreductase HEC78_RS05500 ENOG4105DHQ Histidine kinase HEC78_RS05515 ENOG4108MJ5 VirK protein HEC78_RS05530 ENOG4107RNH Outer membrane receptor FepA HEC78_RS05535 ENOG4105NIV Esterase HEC78_RS05555 ENOG4108C33 Resolvase HEC78_RS05560 ENOG4105I03 Flagellin HEC78_RS05600 ENOG4105DFP Integrase HEC78_RS05635 ENOG4108Z1B Cyclase dehydrase HEC78_RS05645 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC78_RS05650 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HEC78_RS05670 ENOG4108JU6 CBS domain protein HEC78_RS05675 ENOG4106KVJ cytochrome C assembly protein HEC78_RS05680 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HEC78_RS05700 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HEC78_RS05705 ENOG4108KHX Diguanylate cyclase HEC78_RS05710 ENOG4108WS1 HEC78_RS05715 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC78_RS05720 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HEC78_RS05730 ENOG4105CQC Prephenate dehydratase HEC78_RS05740 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC78_RS05780 ENOG4105ED4 portal protein HEC78_RS05870 ENOG4108X9F tail fiber protein HEC78_RS05900 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HEC78_RS05905 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HEC78_RS05910 ENOG4105C34 Pseudouridine synthase HEC78_RS05915 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HEC78_RS05920 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC78_RS05950 ENOG4105CSH Transporter HEC78_RS05955 ENOG4105T42 (LipO)protein HEC78_RS05960 ENOG4105JIM Phosphatidylserine synthase HEC78_RS05965 ENOG4105CD5 CoA-binding domain protein HEC78_RS05970 ENOG4106IUH DTW domain containing protein HEC78_RS05975 ENOG4105K63 Thioredoxin HEC78_RS05980 ENOG4105EIB trna rrna methyltransferase HEC78_RS05990 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HEC78_RS06000 ENOG41090KR LysR family transcriptional Regulator HEC78_RS06005 ENOG4105C1J atp-dependent rna helicase HEC78_RS06015 ENOG4108IYU L-aspartate oxidase HEC78_RS06040 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HEC78_RS06050 ENOG4105C3F Signal peptidase i HEC78_RS06080 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HEC78_RS06085 ENOG4105DND Transcriptional regulator HEC78_RS06095 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEC78_RS06100 ENOG4106G6Q Transcriptional regulator HEC78_RS06115 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HEC78_RS06120 ENOG4108Z6B deaminase HEC78_RS06125 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HEC78_RS06135 ENOG4108ETH Formylglycinamide ribotide synthetase HEC78_RS06140 ENOG4107WP9 Histidine kinase HEC78_RS06145 ENOG4108SKK alpha helix protein HEC78_RS06150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC78_RS06160 ENOG4105DUX Transporter HEC78_RS06165 ENOG4105CXN decarboxylase HEC78_RS06170 ENOG4105D5Q Arginine ornithine antiporter HEC78_RS06175 ENOG4108M3R transcriptional activator CadC HEC78_RS06185 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEC78_RS06195 ENOG4105D8G Major Facilitator superfamily HEC78_RS06200 ENOG4108MN2 Stationary phase inducible protein CsiE HEC78_RS06210 ENOG4105D7X high-affinity nickel-transporter HEC78_RS06215 ENOG410810Y Sulfite reductase HEC78_RS06220 ENOG4107SHJ sulfite reductase subunit b HEC78_RS06230 ENOG4107XM9 (LipO)protein HEC78_RS06235 ENOG4105ECY inositol monophosphatase HEC78_RS06240 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HEC78_RS06255 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HEC78_RS06260 ENOG4108Z4V iron-sulfur cluster assembly HEC78_RS06275 ENOG4108ZIT Ferredoxin, 2FE-2S HEC78_RS06280 ENOG4105WVQ Fe-S assembly protein IscX HEC78_RS06290 ENOG4105YYA enhanced serine sensitivity protein SseB HEC78_RS06300 ENOG4105KHC sulfurtransferase HEC78_RS06305 ENOG4105DN3 alpha-2-macroglobulin domain protein HEC78_RS06310 ENOG4108JQB penicillin-binding protein 1C HEC78_RS06315 ENOG4107QY8 reductase HEC78_RS06320 ENOG4105QAX Iron-sulfur HEC78_RS06360 ENOG4105N21 Membrane HEC78_RS06365 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC78_RS06375 ENOG4105VPD cellular component movement HEC78_RS06415 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEC78_RS06435 ENOG41066DY Membrane HEC78_RS06440 ENOG4108ZMA Outer membrane lipoprotein HEC78_RS06445 ENOG41062G3 Protein of unknown function (DUF2633) HEC78_RS06455 ENOG4105BZU Histidine kinase HEC78_RS06460 ENOG4105C9X ppx gppa phosphatase HEC78_RS06465 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HEC78_RS06470 ENOG4108V3E phosphoribosylglycinamide formyltransferase HEC78_RS06480 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HEC78_RS06485 ENOG4105C2W permease HEC78_RS06495 ENOG4105K89 arsenate reductase HEC78_RS06500 ENOG4105ERG peptidase m48, ste24p HEC78_RS06505 ENOG4105C02 permease HEC78_RS06510 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HEC78_RS06515 ENOG4107QQ0 gntp family HEC78_RS06520 ENOG4105BZW Glycerate kinase HEC78_RS06525 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HEC78_RS06530 ENOG4105RH4 Glycine cleavage system transcriptional repressor HEC78_RS06535 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEC78_RS06540 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC78_RS06550 ENOG4105CGZ zinc metallopeptidase HEC78_RS06555 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HEC78_RS06565 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HEC78_RS06570 ENOG4105KUZ arsenate reductase HEC78_RS06580 ENOG4105BZS acriflavin resistance protein HEC78_RS06585 ENOG4105BZU Histidine kinase HEC78_RS06590 ENOG4105BZ8 glutamate synthase HEC78_RS06600 ENOG4107VIJ nudix hydrolase HEC78_RS06605 ENOG4108PVD exported protein HEC78_RS06615 ENOG4105CV1 Transketolase (EC 2.2.1.1) HEC78_RS06620 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEC78_RS06625 ENOG4105C6K Malic enzyme HEC78_RS06630 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HEC78_RS06635 ENOG4106S4J ethanolamine utilization protein EutP HEC78_RS06640 ENOG4105NDK ethanolamine utilization protein HEC78_RS06645 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HEC78_RS06650 ENOG4108IJ2 phosphate acetyltransferase HEC78_RS06655 ENOG4105KNY Microcompartments protein HEC78_RS06660 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HEC78_RS06665 ENOG4108EKI Dehydrogenase HEC78_RS06670 ENOG4107YMV ethanolamine utilization protein HEC78_RS06675 ENOG4105C0A alcohol dehydrogenase HEC78_RS06680 ENOG4105ENY Ethanolamine utilization protein eutH HEC78_RS06685 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HEC78_RS06690 ENOG4105CPD ethanolamine ammonia-lyase HEC78_RS06700 ENOG4106D67 ethanolamine utilization protein HEC78_RS06705 ENOG4108X49 Ethanolamine utilization protein EutK HEC78_RS06710 ENOG4108K3Z AraC family transcriptional regulator HEC78_RS06720 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HEC78_RS06725 ENOG4108R6G acetyltransferase HEC78_RS06730 ENOG4105QZU Inner membrane protein YfeZ HEC78_RS06735 ENOG4105E7K (LipO)protein HEC78_RS06740 ENOG4105EZR dyp-type peroxidase family protein HEC78_RS06745 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HEC78_RS06750 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HEC78_RS06755 ENOG4108I5D sulfate abc transporter HEC78_RS06760 ENOG4105ECW sulfate abc transporter HEC78_RS06765 ENOG4108IJ6 ABC transporter HEC78_RS06770 ENOG4105C6T cysteine synthase HEC78_RS06775 ENOG4105M0Y HEC78_RS06780 ENOG41089BK Glutamine amido-transferase HEC78_RS06785 ENOG4105CSW GntR family transcriptional regulator HEC78_RS06790 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HEC78_RS06800 ENOG4105C5Y PTS System HEC78_RS06805 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HEC78_RS06815 ENOG4105C6T cysteine synthase HEC78_RS06835 ENOG4105VRT cytoplasmic protein HEC78_RS06840 ENOG4105DHU Bile acid HEC78_RS06845 ENOG4108M0I Transcriptional regulator HEC78_RS06850 ENOG4108NFH Sugar hydrolase HEC78_RS06855 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HEC78_RS06860 ENOG4105EAA nucleoside HEC78_RS06870 ENOG4105CN8 Transcriptional regulator HEC78_RS06900 ENOG4105GXM Putative transcription regulator (DUF1323) HEC78_RS06905 ENOG4105HZG regulatoR HEC78_RS06920 ENOG4108KMM Diguanylate cyclase HEC78_RS06925 ENOG4105D9N nucleoside HEC78_RS06935 ENOG4109076 Conserved Protein HEC78_RS06940 ENOG4105CPC Aldo Keto reductase HEC78_RS06945 ENOG4107RA9 decarboxylase HEC78_RS06965 ENOG4105CHM Aminotransferase HEC78_RS06975 ENOG4105D1S lipid A biosynthesis HEC78_RS06980 ENOG4105W9M Membrane HEC78_RS06985 ENOG4105CXY transporter HEC78_RS06990 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HEC78_RS07000 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HEC78_RS07005 ENOG4108NC2 Outer membrane protease HEC78_RS07030 ENOG4105CKK Glycosyl transferase, family 2 HEC78_RS07035 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HEC78_RS07040 ENOG4108BUD transposase HEC78_RS07055 ENOG4105S64 Formate nitrite transporter HEC78_RS07060 ENOG410903C (LipO)protein HEC78_RS07065 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HEC78_RS07070 ENOG4105KZW UPF0381 protein HEC78_RS07085 ENOG4108BY2 phosphohistidine phosphatase HEC78_RS07095 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HEC78_RS07110 ENOG4105EJ9 Membrane HEC78_RS07115 ENOG4108BPE -transporting atpase HEC78_RS07120 ENOG4105MH2 YfcL protein HEC78_RS07125 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HEC78_RS07130 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEC78_RS07160 ENOG4106WZ1 flagella biosynthesis regulator HEC78_RS07170 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HEC78_RS07180 ENOG4105DQR SNARE associated Golgi HEC78_RS07190 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HEC78_RS07195 ENOG4108S3P Sporulation domain protein HEC78_RS07200 ENOG4105E96 Colicin v production protein HEC78_RS07205 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HEC78_RS07210 ENOG4108JUB Transcriptional regulator HEC78_RS07220 ENOG4105E5D amino acid HEC78_RS07225 ENOG4106M28 alanine racemase domain protein HEC78_RS07235 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEC78_RS07240 ENOG4105E89 ABC transporter HEC78_RS07245 ENOG4105E89 ABC transporter HEC78_RS07250 ENOG4105DSP amino acid AbC transporter HEC78_RS07255 ENOG4106YG3 ABC transporter HEC78_RS07260 ENOG4108JEH abc transporter atp-binding protein HEC78_RS07265 ENOG4105ECP epimerase HEC78_RS07270 ENOG4105CYM Glutathione S-transferase HEC78_RS07275 ENOG4108SHQ Glutathione S-transferase HEC78_RS07280 ENOG4108RE9 Phosphodiesterase HEC78_RS07285 ENOG4105PTV Nudix Hydrolase HEC78_RS07290 ENOG4105K2J Transcriptional regulator HEC78_RS07295 ENOG4106ETB IIa component HEC78_RS07305 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HEC78_RS07310 ENOG4108HHA Transketolase HEC78_RS07315 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HEC78_RS07320 ENOG4105CSX c4-dicarboxylate anaerobic carrier HEC78_RS07325 ENOG4105C6K Malic enzyme HEC78_RS07330 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEC78_RS07345 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HEC78_RS07350 ENOG4107QWE )-transporter HEC78_RS07360 ENOG4105CHM Aminotransferase HEC78_RS07365 ENOG4107NQ8 LysR family Transcriptional regulator HEC78_RS07375 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEC78_RS07380 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC78_RS07390 ENOG4105GKE subunit e HEC78_RS07395 ENOG4107QIZ NADH dehydrogenase HEC78_RS07400 ENOG4108IEH NADH dehydrogenase subunit g HEC78_RS07415 ENOG4107UFS subunit j HEC78_RS07425 ENOG4105D65 subunit l HEC78_RS07430 ENOG4105C8S subunit m HEC78_RS07450 ENOG4107YB6 acetyltransferase, (GNAT) family HEC78_RS07455 ENOG4105TNS Conserved Protein HEC78_RS07460 ENOG4105E4F Isochorismate synthase HEC78_RS07475 ENOG4108IPT Naphthoate synthase HEC78_RS07485 ENOG4105CEY Amp-dependent synthetase and ligase HEC78_RS07490 ENOG4106GZG polymyxin resistance protein B HEC78_RS07545 ENOG4108EWA cinA-like protein HEC78_RS07555 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HEC78_RS07565 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HEC78_RS07570 ENOG4105CXY transporter HEC78_RS07575 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HEC78_RS07580 ENOG4105GZI Transcriptional regulator HEC78_RS07585 ENOG4105CZM Major Facilitator HEC78_RS07590 ENOG4105XPH Ferredoxin HEC78_RS07595 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC78_RS07600 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC78_RS07620 ENOG4105CXK mandelate racemase muconate lactonizing HEC78_RS07625 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC78_RS07630 ENOG4105BZU Histidine kinase HEC78_RS07635 ENOG41068CG regulatoR HEC78_RS07640 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HEC78_RS07645 ENOG4105FCK Membrane HEC78_RS07650 ENOG4105CJ2 (LipO)protein HEC78_RS07655 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEC78_RS07660 ENOG4105CF1 Alkylated DNA repair protein HEC78_RS07665 ENOG4105IBP Cyclic peptide transporter HEC78_RS07675 ENOG4108ZNS ferredoxin-type protein NapF HEC78_RS07680 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HEC78_RS07690 ENOG4108BGM Quinol dehydrogenase periplasmic component HEC78_RS07695 ENOG4105GXZ Ferredoxin-type protein NapH HEC78_RS07700 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HEC78_RS07705 ENOG4105CUW cytochrome C-TYPE protein HEC78_RS07715 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HEC78_RS07720 ENOG41060IM Heme exporter protein HEC78_RS07725 ENOG4105X3C heme exporter protein HEC78_RS07735 ENOG4105DA4 cytochrome c-type biogenesis protein HEC78_RS07740 ENOG4107QX9 Thiol disulfide interChange protein HEC78_RS07745 ENOG4105KWW Biogenesis protein HEC78_RS07750 ENOG4105WH1 Two component transcriptional regulator luxr family HEC78_RS07790 ENOG4105E68 Sulfatase HEC78_RS07815 ENOG4105CFI type iii restriction protein res subunit HEC78_RS07820 ENOG4105I08 Pseudouridine synthase HEC78_RS07825 ENOG4105C2C drug resistance transporter, Bcr CflA HEC78_RS07830 ENOG4105HG6 HEC78_RS07835 ENOG4108JQ5 ABC transporter HEC78_RS07840 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HEC78_RS07845 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HEC78_RS07850 ENOG4105E43 Extracellular solute-binding protein, family 5 HEC78_RS07855 ENOG4105CXC rtn protein HEC78_RS07860 ENOG4107TT5 NLP P60 protein HEC78_RS07865 ENOG41076MN Phosphoesterase, PA-phosphatase related HEC78_RS07870 ENOG4105CKI cobalamin synthesis protein HEC78_RS07875 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HEC78_RS07880 ENOG4105KRS Proteinase inhibitor HEC78_RS07895 ENOG4105S8Q sugar efflux transporter HEC78_RS07900 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HEC78_RS07905 ENOG4105DE4 1-phosphofructokinase HEC78_RS07910 ENOG4105DM4 PTS System HEC78_RS07915 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HEC78_RS07920 ENOG4105HMI Membrane HEC78_RS07925 ENOG4105DUM transcriptional regulator, lysR family HEC78_RS07930 ENOG4108IQI permease HEC78_RS07935 ENOG4105D05 Receptor HEC78_RS07940 ENOG4105CXY transporter HEC78_RS07945 ENOG4105EAC phosphoserine phosphatase HEC78_RS07950 ENOG4105EJQ L-serine dehydratase HEC78_RS07965 ENOG4105EUJ GTP cyclohydrolase i HEC78_RS07970 ENOG4105DHF Membrane HEC78_RS07975 ENOG41060NJ transcriptional regulator HEC78_RS07980 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HEC78_RS07985 ENOG4105C2J ABC transporter HEC78_RS07990 ENOG4107SDZ Galactoside transport system permease protein mglC HEC78_RS07995 ENOG4107SJI Dehydrogenase HEC78_RS08000 ENOG4105BZ8 glutamate synthase HEC78_RS08005 ENOG4105Y9N Membrane HEC78_RS08010 ENOG4107GZ4 SanA protein HEC78_RS08020 ENOG41067MG lrgb family HEC78_RS08050 ENOG4108RXX maleylacetoacetate isomerase HEC78_RS08055 ENOG4105MSY salicylate hydroxylase HEC78_RS08060 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HEC78_RS08070 ENOG4105ETP RND efflux system, outer membrane lipoprotein HEC78_RS08075 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEC78_RS08080 ENOG4105KHU inner membrane protein YohD HEC78_RS08085 ENOG41069YE inner membrane protein yohC HEC78_RS08090 ENOG41061WM D-Alanyl-D-Alanine HEC78_RS08095 ENOG4105CXG d-lactate dehydrogenase HEC78_RS08100 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEC78_RS08105 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HEC78_RS08110 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HEC78_RS08115 ENOG4108IJ8 ABC transporter HEC78_RS08120 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HEC78_RS08135 ENOG4108HRK Histidine kinase HEC78_RS08140 ENOG4108NEV two component transcriptional regulator, LytTR family HEC78_RS08145 ENOG4108W15 Protein of unknown function (DUF1456) HEC78_RS08155 ENOG4108YCW (LipO)protein HEC78_RS08165 ENOG4105D1F ATP-binding protein HEC78_RS08180 ENOG4108MQF Chaperone HEC78_RS08185 ENOG4105CW0 outer membrane usher protein HEC78_RS08195 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HEC78_RS08205 ENOG4105DWF phosphomethylpyrimidine kinase HEC78_RS08210 ENOG4105FDP GntR family transcriptional regulator HEC78_RS08215 ENOG4108TFM Kinase, PfkB family HEC78_RS08220 ENOG4108KD5 ADP-ribosylation crystallin J1 HEC78_RS08225 ENOG4105EAA nucleoside HEC78_RS08230 ENOG4105EIE fructose-bisphosphate aldolase HEC78_RS08245 ENOG41090V3 Tir chaperone protein (CesT) family HEC78_RS08255 ENOG4105CFP Peptidase U32 HEC78_RS08295 ENOG4105CNA YD repeat protein HEC78_RS08300 ENOG4105CNA YD repeat protein HEC78_RS08310 ENOG4105NUP lyase containing HEAT-repeat HEC78_RS08360 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC78_RS08365 ENOG4105EB3 Histidine kinase HEC78_RS08395 ENOG4105R8A Heat shock protein HEC78_RS08400 ENOG4105D03 DNA-3-methyladenine glycosylase II HEC78_RS08405 ENOG4105BZU Histidine kinase HEC78_RS08420 ENOG4108GAE asmA family HEC78_RS08425 ENOG4105EE5 Membrane protein terC HEC78_RS08430 ENOG4105DAY polysaccharide export protein HEC78_RS08435 ENOG4105KJF protein tyrosine phosphatase HEC78_RS08440 ENOG4105D75 Capsular exopolysaccharide family HEC78_RS08445 ENOG41090RK glycosyl transferase HEC78_RS08450 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HEC78_RS08455 ENOG4107RXY Glycosyl transferase HEC78_RS08460 ENOG4108NYJ Colanic acid HEC78_RS08465 ENOG4105ECJ Glycosyl Transferase HEC78_RS08470 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HEC78_RS08475 ENOG4105C0K Gdp-mannose 4,6-dehydratase HEC78_RS08480 ENOG4105C30 Nad-dependent epimerase dehydratase HEC78_RS08485 ENOG4105FGF GDP-mannose mannosyl hydrolase HEC78_RS08490 ENOG4106CD9 glycosyl transferase group 1 HEC78_RS08495 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HEC78_RS08500 ENOG4107QKV phosphomannomutase HEC78_RS08505 ENOG4105D3Q Sugar transferase HEC78_RS08510 ENOG4105PSV Polysaccharide Biosynthesis Protein HEC78_RS08515 ENOG4105C74 pyruvyl transferase HEC78_RS08520 ENOG4107T8Q Glycosyl transferase (Group 1 HEC78_RS08525 ENOG4105G1A colanic acid biosynthesis protein HEC78_RS08530 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEC78_RS08535 ENOG4105C1B dTDP-glucose 4-6-dehydratase HEC78_RS08540 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HEC78_RS08545 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HEC78_RS08550 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEC78_RS08555 ENOG4107QK7 reductase HEC78_RS08560 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HEC78_RS08565 ENOG4105FAW cDP-glucose 4,6-dehydratase HEC78_RS08570 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HEC78_RS08575 ENOG4108SMP Nad-dependent epimerase dehydratase HEC78_RS08580 ENOG4105FB1 Polysaccharide Biosynthesis Protein HEC78_RS08585 ENOG4107YYJ Glycosyl transferase, family 2 HEC78_RS08595 ENOG4108KBE Glycosyl transferase, family 2 HEC78_RS08600 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HEC78_RS08605 ENOG4106ECQ phosphomannomutase HEC78_RS08610 ENOG4105D3Q Sugar transferase HEC78_RS08615 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HEC78_RS08620 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEC78_RS08625 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HEC78_RS08630 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HEC78_RS08645 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HEC78_RS08650 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HEC78_RS08675 ENOG4107SRH Nad-dependent epimerase dehydratase HEC78_RS08680 ENOG4105EQ1 Transcriptional regulator HEC78_RS08690 ENOG4105CUB amino acid HEC78_RS08695 ENOG4105CJB Exodeoxyribonuclease I HEC78_RS08710 ENOG4108J2R molybdopterin oxidoreductase HEC78_RS08715 ENOG4105QAX Iron-sulfur HEC78_RS08720 ENOG4108NWD Cytochrome HEC78_RS08725 ENOG4105DZ1 carboxypeptidase HEC78_RS08730 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HEC78_RS08735 ENOG4105DR8 Membrane HEC78_RS08740 ENOG41090HJ UPF0265 protein HEC78_RS08745 ENOG4105JZC GHMP kinase HEC78_RS08750 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEC78_RS08755 ENOG4105KTW ethanolamine utilization protein HEC78_RS08760 ENOG4105M3W utilization protein HEC78_RS08770 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HEC78_RS08775 ENOG4105C0A alcohol dehydrogenase HEC78_RS08780 ENOG4108EKI Dehydrogenase HEC78_RS08790 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HEC78_RS08800 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HEC78_RS08810 ENOG4105KNY Microcompartments protein HEC78_RS08820 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HEC78_RS08825 ENOG4108ZFT Dehydratase small subunit HEC78_RS08830 ENOG4105YCI dehydratase medium subunit HEC78_RS08835 ENOG4105DMB glycerol dehydratase HEC78_RS08840 ENOG4105EHR propanediol utilization protein pduB HEC78_RS08845 ENOG4105KNY Microcompartments protein HEC78_RS08850 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEC78_RS08855 ENOG4107XVH Transcriptional regulator HEC78_RS08860 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEC78_RS08865 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HEC78_RS08870 ENOG41081F0 Precorrin-8x methylmutase HEC78_RS08880 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HEC78_RS08885 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HEC78_RS08890 ENOG4105CIA precorrin-4 C(11)-methyltransferase HEC78_RS08895 ENOG4108P62 biosynthesis protein (CbiG) HEC78_RS08900 ENOG4105E4R Precorrin-3B C17-methyltransferase HEC78_RS08905 ENOG4105QUC reductase HEC78_RS08910 ENOG4107PPM cobalt chelatase HEC78_RS08915 ENOG4105DVK Precorrin-2 c20-methyltransferase HEC78_RS08920 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEC78_RS08925 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEC78_RS08930 ENOG4108V4M Cobalt abc transporter HEC78_RS08935 ENOG4108JJB ABC transporter HEC78_RS08945 ENOG4108YZT Adenosylcobinamide kinase HEC78_RS08960 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC78_RS08970 ENOG4105UQX Mate efflux family protein HEC78_RS08990 ENOG4105HVQ Regulatory factor of maltose metabolism HEC78_RS09025 ENOG4105FYV Amp nucleosidase HEC78_RS09030 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HEC78_RS09035 ENOG4105KVH Transcriptional regulator HEC78_RS09095 ENOG4108YX2 DNA-binding protein HEC78_RS09195 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HEC78_RS09205 ENOG4105DFP Integrase HEC78_RS09215 ENOG4105KT5 UmuD protein HEC78_RS09220 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEC78_RS09235 ENOG4105FCK Membrane HEC78_RS09240 ENOG4105Y0K Inner membrane protein YedR HEC78_RS09245 ENOG4105EST Metal Dependent Phosphohydrolase HEC78_RS09250 ENOG4105DVF Cytosine-specific methyltransferase HEC78_RS09255 ENOG41090BB DNA mismatch endonuclease (vsr) HEC78_RS09260 ENOG4105FDR Membrane HEC78_RS09265 ENOG4105CKW Inner membrane protein yedI HEC78_RS09270 ENOG4105VNZ cytoplasmic protein HEC78_RS09280 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase HEC78_RS09285 ENOG4105YX3 cellular response to acidity HEC78_RS09295 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HEC78_RS09300 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HEC78_RS09305 ENOG4105VS8 Flagellar biosynthetic protein fliq HEC78_RS09310 ENOG4105CN7 Flagellar biosynthetic protein FliP HEC78_RS09315 ENOG4105K0P flagellar biosynthesis protein HEC78_RS09320 ENOG4105DD5 Flagellar motor switch protein HEC78_RS09325 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HEC78_RS09330 ENOG4107ZI8 flagellar basal body-associated protein flil HEC78_RS09335 ENOG4105WF4 Flagellar hook-length control protein HEC78_RS09340 ENOG4105GSA Flagellar export protein flij HEC78_RS09345 ENOG4108JIR Flagellum-specific ATP synthase HEC78_RS09350 ENOG41090PJ Flagellar assembly protein HEC78_RS09355 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HEC78_RS09360 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HEC78_RS09380 ENOG41066VF YeeE YedE family protein HEC78_RS09385 ENOG4105JCU Inherit from NOG: (Lipo)protein HEC78_RS09390 ENOG4105E5K Alpha-amylase HEC78_RS09400 ENOG4105MQ3 flagellar protein FliS HEC78_RS09405 ENOG4105DTS flagellar hook-associated HEC78_RS09420 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC78_RS09425 ENOG4108M9K flagella biosynthesis protein FliZ HEC78_RS09430 ENOG4105EAB amino acid AbC transporter HEC78_RS09440 ENOG4105E5Q amino acid AbC transporter HEC78_RS09445 ENOG4105CDA abc transporter atp-binding protein HEC78_RS09450 ENOG4105VJY transcriptional regulator HEC78_RS09455 ENOG4105XVG cytoplasmic protein HEC78_RS09465 ENOG4105WH1 Two component transcriptional regulator luxr family HEC78_RS09510 ENOG4106RHG Yeca family HEC78_RS09515 ENOG4105E0U tyrosine-specific transport protein HEC78_RS09520 ENOG4105VVZ metal-binding protein HEC78_RS09525 ENOG41090A1 ferritin HEC78_RS09530 ENOG4105P23 (LipO)protein HEC78_RS09540 ENOG4108UEC Ferritin-like protein HEC78_RS09555 ENOG4108K4C ec 3.1.3.12 HEC78_RS09565 ENOG4108VA4 Universal stress protein HEC78_RS09575 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HEC78_RS09580 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HEC78_RS09585 ENOG4107RD7 Flagellar Motor Protein, MotA HEC78_RS09590 ENOG4105ER2 Ompa motb domain protein HEC78_RS09595 ENOG4105CBS Chea signal transduction histidine kinase HEC78_RS09600 ENOG4108V3W Chemotaxis protein, CheW HEC78_RS09605 ENOG4105C8Q Methyl-accepting chemotaxis HEC78_RS09610 ENOG4105BZU Histidine kinase HEC78_RS09620 ENOG4108VYJ response regulator receiver protein HEC78_RS09625 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HEC78_RS09630 ENOG4105D00 flagellar biosynthetic protein flhB HEC78_RS09635 ENOG4105D7B Flagellar biosynthesis protein flha HEC78_RS09640 ENOG4105IRD Flagellar protein FlhE HEC78_RS09645 ENOG4105F5H Glycosyl Hydrolase Family 88 HEC78_RS09660 ENOG4106ZCM YecM protein HEC78_RS09680 ENOG4105WJG Glutathione HEC78_RS09685 ENOG41081XQ Conserved Protein HEC78_RS09690 ENOG4105D3W isochorismatase HEC78_RS09700 ENOG4108TIT dATP pyrophosphohydrolase HEC78_RS09705 ENOG4105CDY transcriptional regulatory protein HEC78_RS09715 ENOG4107S01 Repressor protein MetJ HEC78_RS09735 ENOG4105FAV ABC, transporter HEC78_RS09740 ENOG4105FDK ABC transporter HEC78_RS09745 ENOG4105NXV High-affinity zinc uptake system protein HEC78_RS09750 ENOG4105DR5 peptidase HEC78_RS09755 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HEC78_RS09760 ENOG4105CA9 Pyruvate kinase HEC78_RS09765 ENOG4106KNT transcriptional regulator HEC78_RS09770 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HEC78_RS09775 ENOG4105C01 Dihydroxy-acid dehydratase HEC78_RS09780 ENOG4108UHU Aldolase HEC78_RS09785 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HEC78_RS09790 ENOG4105X2V dna damage-inducible protein HEC78_RS09800 ENOG4108Q2J Inner membrane protein YebE HEC78_RS09805 ENOG4105CUG Oligopeptidase b HEC78_RS09810 ENOG4105UMD exodeoxyribonuclease X HEC78_RS09815 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HEC78_RS09820 ENOG4105MPK DNA polymerase III subunit theta HEC78_RS09825 ENOG4105FXM Copper resistance protein HEC78_RS09830 ENOG4108PNC copper resistance HEC78_RS09835 ENOG4105NKT exported protein HEC78_RS09840 ENOG4108I1J Integrase HEC78_RS09905 ENOG41064WM Uncharacterized protein YcgX HEC78_RS09910 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling HEC78_RS09920 ENOG4108R1E Serine threonine protein phosphatase 1 HEC78_RS09925 ENOG4105UVW uncharacterized protein yebW HEC78_RS09930 ENOG4105WT8 Protein of unknown function (DUF1480) HEC78_RS09940 ENOG4105DY2 Paraquat-inducible protein b HEC78_RS09945 ENOG4105H2K paraquat-inducible protein a HEC78_RS09950 ENOG4108ZGC gaf domain protein HEC78_RS09960 ENOG4105CN1 protease HEC78_RS09965 ENOG4105D0M Protease HtpX homolog HEC78_RS09970 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC78_RS09975 ENOG4105J4Q Transcriptional regulator HEC78_RS09985 ENOG4106CCY Protein MgrB homolog HEC78_RS09990 ENOG4105Q3Y exported protein HEC78_RS10005 ENOG4105CJN penicillin-binding protein HEC78_RS10010 ENOG4105DHI Methyltransferase HEC78_RS10025 ENOG4105F3R pts system mannose fructose sorbose family iid HEC78_RS10030 ENOG4105ETZ PTS System HEC78_RS10035 ENOG4105DAS pts system HEC78_RS10040 ENOG4105EE5 Membrane protein terC HEC78_RS10045 ENOG4107XTP (EAL) domain protein HEC78_RS10050 ENOG4105EJQ L-serine dehydratase HEC78_RS10060 ENOG4105CRQ synthase (Component I) HEC78_RS10065 ENOG4105X5C UPF0181 protein HEC78_RS10070 ENOG4105M4H endoribonuclease L-psp HEC78_RS10075 ENOG4105DVT helicase HEC78_RS10080 ENOG41072GX Peptidase M22 Glycoprotease HEC78_RS10085 ENOG4105Y4Z Outer Membrane Lipoprotein HEC78_RS10090 ENOG4105CEY Amp-dependent synthetase and ligase HEC78_RS10095 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HEC78_RS10105 ENOG4107QMS site-determining protein HEC78_RS10120 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HEC78_RS10135 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HEC78_RS10145 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HEC78_RS10160 ENOG4105ED1 spovr family HEC78_RS10170 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEC78_RS10180 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HEC78_RS10190 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HEC78_RS10205 ENOG4105D82 Glutamate dehydrogenase HEC78_RS10215 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEC78_RS10220 ENOG4105C4M (Ubiquinol oxidase) subunit I HEC78_RS10225 ENOG4105MVP hydrogenase-1 operon protein HyaF HEC78_RS10230 ENOG4108VXY Hydrogenase-1 operon protein HyaE HEC78_RS10235 ENOG4108USZ hydrogenase HEC78_RS10240 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HEC78_RS10310 ENOG4105HVQ Regulatory factor of maltose metabolism HEC78_RS10325 ENOG4108XS9 dna repair protein HEC78_RS10335 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HEC78_RS10370 ENOG4105DB4 HEC78_RS10380 ENOG41065RQ ADP-ribosylation crystallin J1 HEC78_RS10415 ENOG4105F9F transposase HEC78_RS10425 ENOG4105DFP Integrase HEC78_RS10430 ENOG4105C3G gtp-binding protein HEC78_RS10440 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HEC78_RS10445 ENOG4105CHH sulfate transporter HEC78_RS10450 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEC78_RS10465 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HEC78_RS10475 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEC78_RS10480 ENOG4108YY7 Invasion gene expression up-regulator SirB HEC78_RS10485 ENOG41063JG Transcriptional regulator HEC78_RS10495 ENOG4105EWV Sodium calcium exchanger membrane region HEC78_RS10500 ENOG4105WS7 Cation transport regulator HEC78_RS10505 ENOG41090EX DsrE family HEC78_RS10510 ENOG4105ID0 Putative invasin HEC78_RS10515 ENOG4105WH1 Two component transcriptional regulator luxr family HEC78_RS10520 ENOG4105BZU Histidine kinase HEC78_RS10525 ENOG4105DQQ Major facilitator superfamily MFS_1 HEC78_RS10530 ENOG4105CRU nitrate reductase, alpha subunit HEC78_RS10535 ENOG4108IUE nitrate reductase beta subunit HEC78_RS10540 ENOG4105R3A Nitrate reductase HEC78_RS10545 ENOG41076YT nitrate reductase, gamma subunit HEC78_RS10575 ENOG4105CIY formyltetrahydrofolate deformylase HEC78_RS10585 ENOG4105D78 K07001 NTE family protein HEC78_RS10590 ENOG4105I93 response regulator HEC78_RS10595 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEC78_RS10610 ENOG4105C0A alcohol dehydrogenase HEC78_RS10615 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HEC78_RS10620 ENOG4107QSI ABC, transporter HEC78_RS10625 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC78_RS10630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEC78_RS10635 ENOG4105C3U ABC transporter HEC78_RS10640 ENOG4108JQ7 (ABC) transporter HEC78_RS10645 ENOG4105EYW Ion transport protein HEC78_RS10665 ENOG4105K9H YciI-like protein HEC78_RS10670 ENOG410822N TonB family HEC78_RS10675 ENOG4105NAU thioesterase Superfamily protein HEC78_RS10690 ENOG4105PI0 Ferredoxin HEC78_RS10695 ENOG4105EIF outer membrane protein W HEC78_RS10700 ENOG4105WEF catalase HEC78_RS10705 ENOG4108N8X transition metal ion binding HEC78_RS10710 ENOG4108Z9Z response to DNA damage stimulus HEC78_RS10730 ENOG4105DK0 Indole-3-glycerol phosphate synthase HEC78_RS10735 ENOG4108EFP Anthranilate synthase component II HEC78_RS10740 ENOG4105CRQ synthase (Component I) HEC78_RS10750 ENOG4105DB7 PHP domain protein HEC78_RS10755 ENOG4107RTD sua5 ycio yrdc ywlc family protein HEC78_RS10760 ENOG4105FE9 pseudouridine synthase HEC78_RS10765 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HEC78_RS10770 ENOG4105UBK short-chain dehydrogenase reductase HEC78_RS10775 ENOG4105ERU peptidase HEC78_RS10780 ENOG4105RKX Protein of unknown function (DUF2498) HEC78_RS10785 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEC78_RS10790 ENOG4107R11 Transcriptional regulator HEC78_RS10805 ENOG4107QM5 aconitate hydratase HEC78_RS10810 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HEC78_RS10815 ENOG4105EYK Phosphatidylglycerophosphatase B HEC78_RS10820 ENOG4105Q4A inner membrane protein yciS HEC78_RS10825 ENOG4105CFV Tetratricopeptide repeat protein HEC78_RS10835 ENOG4108ZJT translation initiation factor, Sui1 HEC78_RS10840 ENOG41061RM osmotically inducible lipoprotein HEC78_RS10845 ENOG4105N2W Transcriptional regulator HEC78_RS10855 ENOG4105BZU Histidine kinase HEC78_RS10865 ENOG4105Q4T oxidoreductase HEC78_RS10870 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HEC78_RS10895 ENOG4108JQ2 peptide transport system atp-binding protein HEC78_RS10900 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HEC78_RS10905 ENOG4108EU3 peptide transport system, permease HEC78_RS10945 ENOG4108EKA peptide transport system, permease HEC78_RS10950 ENOG4108J59 Extracellular solute-binding protein, family 5 HEC78_RS10955 ENOG4105E51 psp operon transcriptional activator HEC78_RS10960 ENOG41087YS Phage shock protein A HEC78_RS10965 ENOG4105YYT phage shock protein B HEC78_RS10970 ENOG4105FM1 phage shock protein C HEC78_RS10975 ENOG4105NNG Peripheral inner membrane phage-shock protein HEC78_RS10980 ENOG4105K8Z Phage shock protein HEC78_RS10985 ENOG4105CM6 amino acid regulated cytosolic protein HEC78_RS10995 ENOG4108JU8 Transcriptional regulator HEC78_RS11000 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HEC78_RS11005 ENOG4107S8C mandelate racemase muconate lactonizing HEC78_RS11010 ENOG4105KXI murein peptide amidase A HEC78_RS11015 ENOG4107QSI ABC, transporter HEC78_RS11025 ENOG4105HEI LysR family (Transcriptional regulator HEC78_RS11030 ENOG4105CV8 reductase HEC78_RS11035 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HEC78_RS11040 ENOG4108XFH Transcriptional regulator HEC78_RS11055 ENOG4106PHM regulatory protein HEC78_RS11075 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HEC78_RS11095 ENOG4105D64 Mechanosensitive ion channel HEC78_RS11100 ENOG4105S5I Membrane HEC78_RS11105 ENOG4105Q9Y Universal stress protein HEC78_RS11110 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HEC78_RS11115 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEC78_RS11120 ENOG4108DG9 Smr protein MutS2 HEC78_RS11125 ENOG4105C8Q Methyl-accepting chemotaxis HEC78_RS11135 ENOG4105C1J atp-dependent rna helicase HEC78_RS11155 ENOG410814C multidrug resistance protein HEC78_RS11160 ENOG4108RW8 Universal stress protein F HEC78_RS11165 ENOG4108RS6 transposase HEC78_RS11170 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HEC78_RS11180 ENOG4105IKK cytoplasmic protein HEC78_RS11185 ENOG41090X5 Heat shock protein hslJ HEC78_RS11190 ENOG4105C5I Dehydrogenase HEC78_RS11195 ENOG4107H52 Dicarboxylate transport HEC78_RS11200 ENOG410689M (LipO)protein HEC78_RS11205 ENOG4105WXT Conserved Protein HEC78_RS11220 ENOG4105CQ7 ATP-dependent helicase HEC78_RS11225 ENOG4107DB1 DUF218 domain HEC78_RS11230 ENOG4105CPW cytochrome b561 HEC78_RS11235 ENOG4108WF3 methyltransferase HEC78_RS11245 ENOG4105E5Q amino acid AbC transporter HEC78_RS11255 ENOG4105E5Q amino acid AbC transporter HEC78_RS11260 ENOG4107R0W ABC transporter HEC78_RS11270 ENOG4107ZUJ lipid metabolic process HEC78_RS11295 ENOG4105C8Q Methyl-accepting chemotaxis HEC78_RS11300 ENOG4105DDW LysR family Transcriptional regulator HEC78_RS11305 ENOG4105E32 cytoplasmic protein HEC78_RS11310 ENOG4105EBR Carboxylesterase HEC78_RS11315 ENOG4105DJ9 glucan biosynthesis protein HEC78_RS11320 ENOG4108YYC ycei family HEC78_RS11335 ENOG4108PQ7 sgc region transcriptional regulator HEC78_RS11340 ENOG4108RK0 3-epimerase HEC78_RS11345 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HEC78_RS11350 ENOG4106P19 photosystem i assembly btpa HEC78_RS11355 ENOG4105DT3 PTS system, galactitol-specific IIc component HEC78_RS11360 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HEC78_RS11365 ENOG4105CN9 Peptidase m42 family protein HEC78_RS11370 ENOG4108Z9I -acetyltransferase HEC78_RS11375 ENOG4107WE3 acetyltransferase YdcK HEC78_RS11380 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HEC78_RS11385 ENOG41088CC tellurite resistance protein tehB HEC78_RS11390 ENOG4108KKZ (LipO)protein HEC78_RS11395 ENOG4105DKK Benzoate HEC78_RS11400 ENOG4108JCI Transcriptional regulator HEC78_RS11405 ENOG4105CFP Peptidase U32 HEC78_RS11410 ENOG4105RR0 Protein of unknown function (DUF2554) HEC78_RS11430 ENOG4108UQS dipeptidase HEC78_RS11435 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEC78_RS11450 ENOG410654E Membrane HEC78_RS11470 ENOG4105R71 cytoplasmic protein HEC78_RS11475 ENOG4108T9Y Inner membrane protein ydcZ HEC78_RS11480 ENOG4108Z7F N-acetyltransferase HEC78_RS11485 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEC78_RS11490 ENOG4108WYP Transcriptional regulator HEC78_RS11495 ENOG4105CHB tonB-dependent Receptor HEC78_RS11500 ENOG4108NS2 receptor HEC78_RS11505 ENOG4105SUV lipoprotein YgdR HEC78_RS11510 ENOG4105C85 amino acid HEC78_RS11520 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HEC78_RS11525 ENOG4105JAB phenazine biosynthesis protein, phzf family HEC78_RS11530 ENOG4105D0D Nitrate reductase 2, gamma subunit HEC78_RS11535 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HEC78_RS11540 ENOG4108IUE nitrate reductase beta subunit HEC78_RS11545 ENOG4105CRU nitrate reductase, alpha subunit HEC78_RS11550 ENOG4107QND Nitrite extrusion protein HEC78_RS11585 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC78_RS11590 ENOG4108MG3 formate dehydrogenase HEC78_RS11595 ENOG4105DQ4 alcohol dehydrogenase HEC78_RS11610 ENOG4105TPS biofilm-dependent modulation protein HEC78_RS11615 ENOG4108Z9K Osmotically inducible protein HEC78_RS11620 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HEC78_RS11630 ENOG4105XXV Acid-resistance protein HEC78_RS11640 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HEC78_RS11655 ENOG4105C87 Aminotransferase class I and II HEC78_RS11660 ENOG4105DFD Na H antiporter HEC78_RS11665 ENOG41060NJ transcriptional regulator HEC78_RS11705 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HEC78_RS11730 ENOG4108I5G Major Facilitator superfamily HEC78_RS11735 ENOG4105CPQ Dehydrogenase HEC78_RS11740 ENOG4105C6F GntR Family Transcriptional Regulator HEC78_RS11755 ENOG4105DPX Hydrogenase, large subunit HEC78_RS11760 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HEC78_RS11780 ENOG4105MVP hydrogenase-1 operon protein HyaF HEC78_RS11805 ENOG4105FFC UPF0187 protein HEC78_RS11810 ENOG4105M0C cytoplasmic protein HEC78_RS11820 ENOG4105C26 Dehydrogenase HEC78_RS11825 ENOG4105EGI Transcriptional regulator HEC78_RS11840 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEC78_RS11845 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HEC78_RS11850 ENOG4106DNR multiple antibiotic resistance protein HEC78_RS11855 ENOG4108594 Permease of the drug metabolite transporter HEC78_RS11860 ENOG4105E5W Transporter HEC78_RS11870 ENOG4108YDI single-species biofilm formation on inanimate substrate HEC78_RS11875 ENOG4108WTK competence damage-inducible protein HEC78_RS11885 ENOG4105DGW oligopeptidase A HEC78_RS11890 ENOG4105EMU Dehydrogenase HEC78_RS11895 ENOG4107XBN GntR Family Transcriptional Regulator HEC78_RS11900 ENOG41061EV selenium-binding protein YdfZ HEC78_RS11905 ENOG4105DEI Mannitol dehydrogenase HEC78_RS11915 ENOG4105CPQ Dehydrogenase HEC78_RS11935 ENOG4108MK9 spermidine N(1)-acetyltransferase HEC78_RS11945 ENOG4105KBG Protein of unknown function (DUF1161) HEC78_RS11950 ENOG4107QY8 reductase HEC78_RS11955 ENOG4105C3J Cysteine desulfurase HEC78_RS11960 ENOG4105QAX Iron-sulfur HEC78_RS11965 ENOG4107KGK dmso reductase anchor subunit HEC78_RS11970 ENOG4108NEM leader-binding protein dmsD HEC78_RS11975 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HEC78_RS11980 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HEC78_RS11985 ENOG4105E90 ABC transporter HEC78_RS11990 ENOG4108IJ8 ABC transporter HEC78_RS12000 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HEC78_RS12005 ENOG4105DAG ROK family HEC78_RS12010 ENOG4106NZI LysR family Transcriptional regulator HEC78_RS12015 ENOG4105D94 Major Facilitator Superfamily HEC78_RS12025 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HEC78_RS12040 ENOG4105DSF transport protein HEC78_RS12045 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HEC78_RS12050 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HEC78_RS12055 ENOG4105C5D exported protein HEC78_RS12060 ENOG4105D5Q Arginine ornithine antiporter HEC78_RS12065 ENOG4105RA2 Membrane HEC78_RS12070 ENOG4107EXC regulatoR HEC78_RS12080 ENOG4105FCK Membrane HEC78_RS12085 ENOG4105CPN adenine deaminase HEC78_RS12090 ENOG4105JJR Histidine kinase HEC78_RS12100 ENOG4105C9Q fumarate hydratase class II HEC78_RS12105 ENOG4107GFK fumarate HEC78_RS12110 ENOG4105EIP mannose-6-phosphate isomerase HEC78_RS12115 ENOG4106J39 exported protein HEC78_RS12130 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEC78_RS12135 ENOG4105D9R oxidoreductase HEC78_RS12140 ENOG4106C6R beta-lactam resistance protein HEC78_RS12150 ENOG4105M9B inner membrane protein ydgK HEC78_RS12175 ENOG4108UQQ Electron transport complex HEC78_RS12185 ENOG4105CSM endonuclease III HEC78_RS12190 ENOG4105DUX Transporter HEC78_RS12195 ENOG4108K3A Glutathione S-transferase HEC78_RS12215 ENOG410642K Lysozyme inhibitor HEC78_RS12225 ENOG4108XTF Outer Membrane Lipoprotein HEC78_RS12240 ENOG4105Y49 secretion protein, HlyD family HEC78_RS12245 ENOG4105DSW Fusaric acid resistance protein HEC78_RS12250 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEC78_RS12255 ENOG4107RGM aldo keto reductase HEC78_RS12260 ENOG4105XZD Fe-S protein HEC78_RS12265 ENOG4108WUH Transcriptional regulator, TetR family HEC78_RS12270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEC78_RS12275 ENOG4108UYE Lactoylglutathione lyase HEC78_RS12280 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HEC78_RS12285 ENOG4105M2J Glutaredoxin HEC78_RS12290 ENOG4105K4H Nlp p60 protein HEC78_RS12295 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEC78_RS12310 ENOG4105F52 Transcriptional regulator HEC78_RS12315 ENOG4105CZQ inner membrane transport protein YdhC HEC78_RS12320 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEC78_RS12325 ENOG4108R6K riboflavin synthase, subunit alpha HEC78_RS12345 ENOG4108IUF type iii secretion HEC78_RS12350 ENOG4108TN6 type iii secretion HEC78_RS12355 ENOG41083GP type iii secretion HEC78_RS12360 ENOG4108HHI Type III secretion system protein HEC78_RS12365 ENOG41063Q7 Type III secretion system protein HEC78_RS12380 ENOG4108JIR Flagellum-specific ATP synthase HEC78_RS12390 ENOG4106H1D secretion system apparatus protein HEC78_RS12395 ENOG4105UQF type iii secretion HEC78_RS12400 ENOG4106563 type III secretion system apparatus protein HEC78_RS12450 ENOG4106FZW pathogenicity island effector protein HEC78_RS12455 ENOG4108SZ7 secretion system effector HEC78_RS12465 ENOG4105ZQI secreted protein HEC78_RS12495 ENOG4105BZU Histidine kinase HEC78_RS12505 ENOG4108XDN Transcriptional regulator HEC78_RS12510 ENOG4107SEY Conserved Protein HEC78_RS12515 ENOG4105RFR Protein of unknown function (DUF2767) HEC78_RS12520 ENOG4108ZXC Two component transcriptional regulator, luxr family HEC78_RS12525 ENOG4106AFQ Histidine kinase HEC78_RS12530 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC78_RS12535 ENOG4106WHD Tetrathionate reductase HEC78_RS12540 ENOG4105DB1 molybdopterin oxidoreductase HEC78_RS12545 ENOG4108RVA ribokinase HEC78_RS12555 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) HEC78_RS12560 ENOG4105CUB amino acid HEC78_RS12565 ENOG4105CA9 Pyruvate kinase HEC78_RS12585 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC78_RS12600 ENOG4105JRK feS assembly protein SufD HEC78_RS12605 ENOG4105C3K feS assembly ATPase SufC HEC78_RS12610 ENOG4105DIW FeS assembly protein SUFB HEC78_RS12615 ENOG4108Z4V iron-sulfur cluster assembly HEC78_RS12620 ENOG4108ETY sodium dicarboxylate symporter HEC78_RS12625 ENOG410671Z uncharacterized protein ydiH HEC78_RS12630 ENOG4105KA0 thioesterase Superfamily protein HEC78_RS12635 ENOG4105CQB FAD linked oxidase domain protein HEC78_RS12640 ENOG4105IPI Membrane HEC78_RS12650 ENOG4105SUA Ydil protein HEC78_RS12655 ENOG4105EMV Major Facilitator HEC78_RS12660 ENOG4105EMV Major Facilitator HEC78_RS12675 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HEC78_RS12680 ENOG4105C1G acyl-Coa dehydrogenase HEC78_RS12685 ENOG4105W4W Transcriptional regulator HEC78_RS12690 ENOG4105CV7 Electron transfer flavoprotein HEC78_RS12695 ENOG4105C10 Electron transfer flavoprotein HEC78_RS12700 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HEC78_RS12705 ENOG41090P5 ferredoxin-like protein HEC78_RS12710 ENOG4105CEY Amp-dependent synthetase and ligase HEC78_RS12715 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HEC78_RS12725 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC78_RS12750 ENOG4108QBX (LipO)protein HEC78_RS12760 ENOG4108V06 Glutathione peroxidase HEC78_RS12770 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HEC78_RS12775 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HEC78_RS12795 ENOG41082NX 50s ribosomal protein l35 HEC78_RS12800 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HEC78_RS12825 ENOG4108NE3 Salt-induced outer membrane protein HEC78_RS12830 ENOG4105DE4 1-phosphofructokinase HEC78_RS12835 ENOG4105P10 Uncharacterized protein ydiZ HEC78_RS12845 ENOG4107PN8 YfeABCD locus regulator HEC78_RS12850 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HEC78_RS12855 ENOG4107K5X Membrane-bound metal-dependent hydrolase HEC78_RS12860 ENOG4108ETY sodium dicarboxylate symporter HEC78_RS12870 ENOG4105CH6 catalase HEC78_RS12880 ENOG4105F8D glycoside hydrolase family 4 HEC78_RS12900 ENOG4105VCP PTS System HEC78_RS12905 ENOG4105CK1 PTS System HEC78_RS12910 ENOG4105VZJ PTS System HEC78_RS12915 ENOG4105KKI DNA-binding transcriptional activator OsmE HEC78_RS12925 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HEC78_RS12930 ENOG4108SPG Periplasmic Protein HEC78_RS12945 ENOG4105C26 Dehydrogenase HEC78_RS12960 ENOG4105CGK Exodeoxyribonuclease III HEC78_RS12965 ENOG4105M6F mutator MutT protein HEC78_RS12970 ENOG4105MTM Protein of unknown function (DUF1496) HEC78_RS12975 ENOG4105D82 Glutamate dehydrogenase HEC78_RS12980 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEC78_RS12985 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HEC78_RS12990 ENOG41069NU Nitroreductase HEC78_RS12995 ENOG4105D07 Signal peptide peptidase, SppA HEC78_RS13000 ENOG4105HDK L-asparaginase HEC78_RS13005 ENOG4108RWI nicotinamidase HEC78_RS13010 ENOG4105VUT cytoplasmic protein HEC78_RS13020 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEC78_RS13025 ENOG4105DSB aldose 1-epimerase HEC78_RS13030 ENOG4105CV8 reductase HEC78_RS13035 ENOG4105C4X radical SAM domain protein HEC78_RS13040 ENOG4105GNX MltA-interacting MipA family protein HEC78_RS13045 ENOG4105CYN Serine protein kinase HEC78_RS13065 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HEC78_RS13080 ENOG4105R1U AraC Family Transcriptional Regulator HEC78_RS13085 ENOG4105DJ2 Major Facilitator Superfamily HEC78_RS13090 ENOG4105K78 MarR family Transcriptional regulator HEC78_RS13100 ENOG4105UCG Domain of unknown function (DUF333) HEC78_RS13105 ENOG4106G4W HEC78_RS13110 ENOG4105Y3U Transglycosylase-associated protein HEC78_RS13120 ENOG4105YP6 Domain of unknown function (DUF1869) HEC78_RS13125 ENOG4108YS1 cytoplasmic protein HEC78_RS13135 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HEC78_RS13150 ENOG4108Z6Z Transcriptional regulator HEC78_RS13165 ENOG4108MEK Metal-binding protein YodA HEC78_RS13180 ENOG4105D64 Mechanosensitive ion channel HEC78_RS13185 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HEC78_RS13190 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HEC78_RS13215 ENOG4108VKM cytochrome b561 HEC78_RS13225 ENOG4108ZNX Heat shock protein HEC78_RS13250 ENOG4105H38 Membrane HEC78_RS13260 ENOG41060EU Cold shock-like protein HEC78_RS13265 ENOG4106F2Y RICIN HEC78_RS13270 ENOG4105Y50 Virulence Protein HEC78_RS13275 ENOG4108TMH cytolethal distending toxin HEC78_RS13305 ENOG4108RS6 transposase HEC78_RS13310 ENOG4108HMX isocitrate dehydrogenase (NADP) HEC78_RS13315 ENOG4108R99 pseudouridine synthase HEC78_RS13340 ENOG4107QTF adenylosuccinate lyase HEC78_RS13355 ENOG4105EZE Cupin 4 family protein HEC78_RS13370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEC78_RS13385 ENOG4105D38 putrescine abc transporter HEC78_RS13390 ENOG4108HM4 ABC transporter HEC78_RS13395 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HEC78_RS13405 ENOG4105D60 lipoprotein releasing system transmembrane protein HEC78_RS13410 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEC78_RS13415 ENOG4105D60 lipoprotein releasing system transmembrane protein HEC78_RS13420 ENOG4108JA2 transcriptioN-repair coupling factor HEC78_RS13425 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC78_RS13430 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HEC78_RS13435 ENOG4108IND Tetr family transcriptional regulator HEC78_RS13440 ENOG4107MBR 17 kDa surface antigen HEC78_RS13445 ENOG4105CEP NADH dehydrogenase HEC78_RS13465 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HEC78_RS13470 ENOG41090DQ Lipoprotein HEC78_RS13475 ENOG4105K59 histidine triad (HIT) protein HEC78_RS13480 ENOG4105CNM Receptor HEC78_RS13485 ENOG4105CI1 PTS System HEC78_RS13490 ENOG4105F8V Hydrolase, tatD family HEC78_RS13495 ENOG4107QRG dna polymerase iii HEC78_RS13505 ENOG4105HHA aminodeoxychorismate lyase HEC78_RS13510 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HEC78_RS13515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEC78_RS13520 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEC78_RS13525 ENOG4105CHR reductase HEC78_RS13530 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HEC78_RS13535 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEC78_RS13550 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HEC78_RS13560 ENOG4105EI2 Pseudouridine synthase HEC78_RS13565 ENOG4107QQB Ribonuclease E HEC78_RS13570 ENOG4105DTJ flagellar hook-associated protein HEC78_RS13575 ENOG4105E1Q flagellar hook-associated protein HEC78_RS13580 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HEC78_RS13595 ENOG4105CGA flagellar basal-body rod protein FlgG HEC78_RS13600 ENOG4108KPB Flagellar basal-body rod protein FlgF HEC78_RS13605 ENOG4105BZE flagellar hook protein, FlgE HEC78_RS13610 ENOG4105W00 Flagellar hook capping protein HEC78_RS13615 ENOG4108ZC9 flagellar basal-body rod protein flgc HEC78_RS13620 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HEC78_RS13625 ENOG4105CKS Flagella basal body P-ring formation protein flgA HEC78_RS13630 ENOG4105M9M anti-sigma28 factor FlgM HEC78_RS13635 ENOG4105QVD Flagella synthesis protein FlgN HEC78_RS13640 ENOG4105CJR Integral membrane protein (MviN HEC78_RS13645 ENOG4105EP9 oxidoreductase HEC78_RS13655 ENOG4105D9U N-acetyltransferase HEC78_RS13665 ENOG4105E9S glutaredoxin 2 HEC78_RS13670 ENOG4105F3T (LipO)protein HEC78_RS13680 ENOG4105MEA DNA damage-inducible protein i HEC78_RS13685 ENOG4105PVA Biofilm formation regulatory protein BssS HEC78_RS13695 ENOG4106974 biofilm formation HEC78_RS13700 ENOG4105DS1 cytochrome b561 HEC78_RS13705 ENOG4108YYC ycei family HEC78_RS13715 ENOG4105D1S lipid A biosynthesis HEC78_RS13725 ENOG4108W47 Acidic protein msyB HEC78_RS13730 ENOG4105NAC (LipO)protein HEC78_RS13735 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HEC78_RS13745 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HEC78_RS13750 ENOG4107RZC phospholipase d HEC78_RS13755 ENOG4108UVJ appr-1-p processing domain protein HEC78_RS13760 ENOG41068SS HEC78_RS13765 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HEC78_RS13770 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HEC78_RS13775 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HEC78_RS13780 ENOG41086KC Transcriptional regulator HEC78_RS13785 ENOG4108XDW curli assembly protein CsgE HEC78_RS13790 ENOG4108WYR Curli production assembly transport component, CsgF HEC78_RS13795 ENOG4105P8Q Curli production assembly transport component CsgG HEC78_RS13800 ENOG4108RS6 transposase HEC78_RS13805 ENOG4108UQ5 membrane protein YcdZ HEC78_RS13810 ENOG4107XHZ cytoplasmic chaperone TorD family protein HEC78_RS13880 ENOG4107RJ5 oxidoreductase HEC78_RS13885 ENOG4105JHE Major Facilitator Superfamily HEC78_RS13890 ENOG4108QGT oligogalacturonate-specific porin HEC78_RS13900 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HEC78_RS13905 ENOG4107RJ1 sodium solute HEC78_RS13910 ENOG4105QEK Transcriptional regulator HEC78_RS13915 ENOG4105D5M phosphate starvation-inducible protein HEC78_RS13920 ENOG4105CK7 Sodium proline symporter HEC78_RS13935 ENOG4108R86 Transcriptional regulator HEC78_RS13940 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HEC78_RS13945 ENOG4105CS1 NAD(P)H quinone oxidoreductase HEC78_RS13950 ENOG4105XH3 HEC78_RS13955 ENOG4105D6F Phosphatase HEC78_RS13960 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HEC78_RS13965 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEC78_RS13970 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HEC78_RS14025 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HEC78_RS14030 ENOG4105C26 Dehydrogenase HEC78_RS14040 ENOG4108V8F Transcriptional regulator, MarR family HEC78_RS14045 ENOG4105EFA 4-hydroxyphenylacetate HEC78_RS14050 ENOG4107UWN reductase HEC78_RS14055 ENOG4105VT2 5-hydroxyisourate hydrolase HEC78_RS14060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEC78_RS14065 ENOG4107ZY3 Histidine kinase HEC78_RS14080 ENOG4106YSC HEC78_RS14085 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell HEC78_RS14090 ENOG4106HNN Invasion protein HEC78_RS14100 ENOG41084BJ Pentapeptide repeat protein HEC78_RS14115 ENOG4108MN8 Membrane HEC78_RS14125 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HEC78_RS14135 ENOG4108V1U phospholipid-binding protein HEC78_RS14150 ENOG4105K4P CoA-binding domain protein HEC78_RS14160 ENOG4108Z5K methylglyoxal synthase HEC78_RS14165 ENOG41088T4 Helicase IV HEC78_RS14170 ENOG410901E Membrane HEC78_RS14175 ENOG4105EM2 membrane HEC78_RS14180 ENOG4108RZ1 DNA transformation protein HEC78_RS14190 ENOG4105UYK outer membrane protein a HEC78_RS14200 ENOG4105DAN ATP-dependent protease HEC78_RS14210 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HEC78_RS14215 ENOG4108Q2G (LipO)protein HEC78_RS14220 ENOG4105DY2 Paraquat-inducible protein b HEC78_RS14225 ENOG4105F1S paraquat-inducible protein a HEC78_RS14230 ENOG4105C5H ABC transporter HEC78_RS14240 ENOG4105QVC MOSC domain-containing protein HEC78_RS14245 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HEC78_RS14255 ENOG4105CD8 aminopeptidase N HEC78_RS14265 ENOG4105C5S asparaginyl-tRNA synthetase HEC78_RS14270 ENOG4105FCK Membrane HEC78_RS14275 ENOG4105CGF Aromatic amino acid aminotransferase HEC78_RS14280 ENOG4105C5X domain protein HEC78_RS14285 ENOG4105EAQ (twin-arginine translocation) pathway signal HEC78_RS14290 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HEC78_RS14300 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HEC78_RS14310 ENOG4106371 Methyltransferase HEC78_RS14315 ENOG4107S90 membrAne HEC78_RS14320 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HEC78_RS14335 ENOG4105T0Z Conserved Protein HEC78_RS14345 ENOG4105BZ1 (ABC) transporter HEC78_RS14350 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HEC78_RS14355 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HEC78_RS14360 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HEC78_RS14370 ENOG4108K0D peptidase, M48 HEC78_RS14385 ENOG4107VMU Membrane HEC78_RS14390 ENOG4105DDY UPF0142 protein ycaO HEC78_RS14395 ENOG4105TMB Formate nitrite transporter HEC78_RS14400 ENOG4105C6N Formate acetyltransferase HEC78_RS14415 ENOG4105GUS HEC78_RS14420 ENOG4105F1A Pyruvate formate-lyase HEC78_RS14425 ENOG4105E5D amino acid HEC78_RS14435 ENOG4107KGK dmso reductase anchor subunit HEC78_RS14440 ENOG4105QAX Iron-sulfur HEC78_RS14445 ENOG4107QY8 reductase HEC78_RS14455 ENOG4105D1H recombination factor protein RarA HEC78_RS14465 ENOG4105CNU cell division protein FtsK HEC78_RS14470 ENOG4105EW9 transcriptional regulator AsnC family HEC78_RS14475 ENOG4105C3M thioredoxin reductase HEC78_RS14480 ENOG4108JJ9 ABC, transporter HEC78_RS14485 ENOG4108JJ8 (ABC) transporter HEC78_RS14500 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HEC78_RS14505 ENOG4105HEI LysR family (Transcriptional regulator HEC78_RS14510 ENOG4105EUB pirin domain protein HEC78_RS14515 ENOG4105CHJ isochorismatase hydrolase HEC78_RS14535 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC78_RS14545 ENOG4105VEQ Cold shock protein HEC78_RS14550 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEC78_RS14555 ENOG4105DJY efflux transporter, rnd family, mfp subunit HEC78_RS14560 ENOG4108MJ5 VirK protein HEC78_RS14565 ENOG4105CPB ATP-dependent endonuclease of the OLD family HEC78_RS14570 ENOG4105DWU Membrane HEC78_RS14580 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEC78_RS14585 ENOG4105C7K acetolactate synthase HEC78_RS14590 ENOG4105C5W Aldolase HEC78_RS14595 ENOG4105CGD Nad-dependent epimerase dehydratase HEC78_RS14600 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HEC78_RS14605 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HEC78_RS14615 ENOG41064MM (LipO)protein HEC78_RS14620 ENOG4105E5Z arginine transporter ATP-binding subunit HEC78_RS14625 ENOG4106PMH Extracellular solute-binding protein family 3 HEC78_RS14630 ENOG4105GBT ABC transporter HEC78_RS14635 ENOG4105DMR ABC, transporter HEC78_RS14640 ENOG4106TNF Periplasmic binding protein HEC78_RS14665 ENOG4105RBQ inner membrane protein ybjO HEC78_RS14670 ENOG4105D38 putrescine abc transporter HEC78_RS14675 ENOG4105F38 ABC transporter, permease HEC78_RS14680 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEC78_RS14685 ENOG4107RUE extracellular solute-binding protein family 1 HEC78_RS14690 ENOG4108RMJ sensory transduction regulator HEC78_RS14700 ENOG4108DBC nitroreductase HEC78_RS14705 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HEC78_RS14710 ENOG41090BQ Glutaredoxin HEC78_RS14715 ENOG4105GWF inner membrane protein YbjM HEC78_RS14725 ENOG4108RFG Tetr family transcriptional regulator HEC78_RS14730 ENOG4106UW1 Major Facilitator superfamily HEC78_RS14735 ENOG4108HCJ Hydrolase HEC78_RS14740 ENOG4107QF7 multi-drug HEC78_RS14745 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEC78_RS14750 ENOG4107FB0 transcriptional regulator DeoR family HEC78_RS14755 ENOG4105DZ1 carboxypeptidase HEC78_RS14760 ENOG4108TGY Glutathione S-transferase HEC78_RS14765 ENOG4105D8V Glucose sorbosone dehydrogenase HEC78_RS14770 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HEC78_RS14785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC78_RS14790 ENOG4105DEF Extracellular solute-binding protein, family 5 HEC78_RS14795 ENOG4108JQ6 ABC transporter HEC78_RS14800 ENOG4105D44 asparaginase HEC78_RS14805 ENOG4105CVM Molybdenum cofactor synthesis domain protein HEC78_RS14810 ENOG4105D06 uba thif-type nad fad binding protein HEC78_RS14815 ENOG4105F1A Pyruvate formate-lyase HEC78_RS14825 ENOG4108HCJ Hydrolase HEC78_RS14830 ENOG41072TH Protein of unknown function (DUF1479) HEC78_RS14835 ENOG4105C5H ABC transporter HEC78_RS14840 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC78_RS14845 ENOG4105F4P )-transporter HEC78_RS14850 ENOG4105KST dependent repressor HEC78_RS14860 ENOG4108I6E Sulfatase HEC78_RS14865 ENOG4108T1M outer membrane protein x HEC78_RS14880 ENOG4107R0W ABC transporter HEC78_RS14885 ENOG4105E5Q amino acid AbC transporter HEC78_RS14890 ENOG4105CDA abc transporter atp-binding protein HEC78_RS14895 ENOG4105D8X mechanosensitive ion channel HEC78_RS14905 ENOG4105KSC Transcriptional regulator, TraR DksA family HEC78_RS14910 ENOG4105VR4 UPF0379 protein ybiJ HEC78_RS14915 ENOG4108MTB glycosyl transferase family HEC78_RS14920 ENOG4105DVT helicase HEC78_RS14925 ENOG4105C1J atp-dependent rna helicase HEC78_RS14930 ENOG4107MVR Transcriptional regulator HEC78_RS14935 ENOG4105D0S secretion protein (HlyD HEC78_RS14940 ENOG4105CJ1 ABC, transporter HEC78_RS14945 ENOG4107QWP ABC-2 type transporter HEC78_RS14950 ENOG4107QWP ABC-2 type transporter HEC78_RS14955 ENOG4105I9U inner membrane protein ybhQ HEC78_RS14960 ENOG4105X23 Endonuclease Exonuclease phosphatase HEC78_RS14965 ENOG4105DZQ phospholipase D Transphosphatidylase HEC78_RS14970 ENOG4107UXM Membrane HEC78_RS14985 ENOG4105HFZ Membrane HEC78_RS14990 ENOG4108ZAF Molybdopterin HEC78_RS14995 ENOG4105M00 molybdopterin converting factor, subunit 1 HEC78_RS15005 ENOG4108RIR Molybdenum cofactor biosynthesis protein HEC78_RS15015 ENOG4105CHW UPF0052 protein HEC78_RS15030 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HEC78_RS15035 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEC78_RS15050 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEC78_RS15055 ENOG4108V1U phospholipid-binding protein HEC78_RS15085 ENOG4105NBR Pectinesterase HEC78_RS15095 ENOG4108K4B hydrolase HEC78_RS15105 ENOG4105E0C molybdate abc transporter HEC78_RS15110 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HEC78_RS15120 ENOG4105F4R Transcriptional regulator mode HEC78_RS15125 ENOG4105DKW ABC transporter HEC78_RS15135 ENOG4105CMR udp-glucose 4-epimerase HEC78_RS15140 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HEC78_RS15150 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEC78_RS15160 ENOG4105E0A ABC, transporter HEC78_RS15165 ENOG4105EHG Permease protein HEC78_RS15170 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HEC78_RS15175 ENOG4105D9Q decarboxylase (Beta subunit) HEC78_RS15180 ENOG4107QSA Oxaloacetate decarboxylase HEC78_RS15185 ENOG4106AFN Lyase and sodium transporter (By similarity) HEC78_RS15190 ENOG4107QWE )-transporter HEC78_RS15200 ENOG4105C5Q Transcriptional regulator HEC78_RS15210 ENOG4107GFK fumarate HEC78_RS15215 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC78_RS15220 ENOG4105JND homeobox protein HEC78_RS15225 ENOG4105PGM cation diffusion facilitator family transporter HEC78_RS15230 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HEC78_RS15270 ENOG4105UFD tol-pal system protein YbgF HEC78_RS15275 ENOG4105KCK Peptidoglycan-associated lipoprotein HEC78_RS15285 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HEC78_RS15295 ENOG4105E02 MotA TolQ exbB proton channel HEC78_RS15300 ENOG4107YD3 Thioesterase HEC78_RS15305 ENOG4105KJB cyd operon protein YbgE HEC78_RS15315 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEC78_RS15320 ENOG4105C4M (Ubiquinol oxidase) subunit I HEC78_RS15325 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HEC78_RS15335 ENOG4105C7S Dehydrogenase HEC78_RS15340 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEC78_RS15345 ENOG4105E33 succinate dehydrogenase HEC78_RS15350 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEC78_RS15355 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HEC78_RS15360 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HEC78_RS15370 ENOG4105BZN citrate synthase HEC78_RS15375 ENOG4108KK1 membrane protein AbrB duplication HEC78_RS15390 ENOG4107R7A Allophanate hydrolase subunit 2 HEC78_RS15395 ENOG4105P4J Allophanate hydrolase, subunit 1 HEC78_RS15400 ENOG4107QNR UPF0135 protein HEC78_RS15410 ENOG4105CVP deoxyribo-dipyrimidine photolyase HEC78_RS15415 ENOG4105XIQ Protein of unknown function (DUF2517) HEC78_RS15440 ENOG4105C08 Histidine kinase HEC78_RS15445 ENOG4105EEX Two component transcriptional regulator (Winged helix family HEC78_RS15455 ENOG4105CXN decarboxylase HEC78_RS15460 ENOG4105D5Q Arginine ornithine antiporter HEC78_RS15470 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HEC78_RS15475 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HEC78_RS15480 ENOG4105EV9 Alpha Beta Hydrolase HEC78_RS15485 ENOG4105NNH LexA regulated protein HEC78_RS15490 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HEC78_RS15495 ENOG41090R7 Ferric uptake HEC78_RS15500 ENOG4106P55 Transcriptional regulator HEC78_RS15505 ENOG4107EFR Flavocytochrome c HEC78_RS15510 ENOG41079YP Citrate utilization protein b HEC78_RS15515 ENOG4105CSH Transporter HEC78_RS15520 ENOG4105GX6 (LipO)protein HEC78_RS15525 ENOG4105J5J Outer membrane porin HEC78_RS15535 ENOG4105CI1 PTS System HEC78_RS15545 ENOG4105CE4 GlcNAc 6-P deacetylase HEC78_RS15550 ENOG4105E2R ROK family HEC78_RS15555 ENOG4105D4U had-superfamily hydrolase, subfamily iia HEC78_RS15560 ENOG4105CAQ asparagine synthetase HEC78_RS15600 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HEC78_RS15610 ENOG4105C9A Phoh family HEC78_RS15620 ENOG4108JU5 Magnesium and cobalt efflux protein HEC78_RS15625 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HEC78_RS15630 ENOG4107RP9 extracellular solute-binding protein, family 3 HEC78_RS15635 ENOG4105EAD ABC transporter HEC78_RS15640 ENOG4105DRP amino acid AbC transporter HEC78_RS15645 ENOG4105CDA abc transporter atp-binding protein HEC78_RS15660 ENOG4107PAI alpha helical protein HEC78_RS15665 ENOG4108JUB Transcriptional regulator HEC78_RS15670 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HEC78_RS15695 ENOG4105DJF DNA polymerase III, delta' subunit HEC78_RS15700 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HEC78_RS15705 ENOG4107QZB decarboxylase HEC78_RS15710 ENOG4108TGR phosphatase HEC78_RS15715 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HEC78_RS15720 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HEC78_RS15725 ENOG4105CJN penicillin-binding protein HEC78_RS15730 ENOG4105CNI cell division protein FtsW HEC78_RS15735 ENOG4105K6T rare lipoprotein A HEC78_RS15740 ENOG4105DZ1 carboxypeptidase HEC78_RS15745 ENOG4108Z43 UPF0250 protein HEC78_RS15755 ENOG41064T2 transcriptional regulator, lysR family HEC78_RS15775 ENOG4107Z6W Protein CrcB homolog HEC78_RS15790 ENOG4105CEE C4-dicarboxylate transporter HEC78_RS15795 ENOG4106YYS transcriptional regulatory protein HEC78_RS15805 ENOG4105DUA (citrate (pro-3S)-lyase ligase HEC78_RS15810 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HEC78_RS15815 ENOG4105CI0 Citrate lyase HEC78_RS15820 ENOG4105CHY citrate lyase, alpha HEC78_RS15825 ENOG4105YGP holo-ACP synthase CitX HEC78_RS15835 ENOG4107QPK )-transporter HEC78_RS15840 ENOG4105KTS ribonuclease HEC78_RS15845 ENOG4105NXH GreA GreB family elongation factor HEC78_RS15850 ENOG4105E2A Dehydrogenase HEC78_RS15855 ENOG4108U51 Universal stress protein HEC78_RS15865 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC78_RS15870 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEC78_RS15880 ENOG4108JU3 Alkyl hydroperoxide reductase HEC78_RS15885 ENOG4105D3R alkyl hydroperoxide reductase HEC78_RS15890 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HEC78_RS15895 ENOG4105DQS Transcriptional regulator HEC78_RS15900 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HEC78_RS15905 ENOG4105GTN ParB Domain Protein Nuclease HEC78_RS15910 ENOG4105CHM Aminotransferase HEC78_RS15915 ENOG4107SCQ Iron-containing alcohol dehydrogenase HEC78_RS15920 ENOG4105VCD cytoplasmic protein HEC78_RS15925 ENOG4105D22 carbon starvation protein HEC78_RS15935 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HEC78_RS15940 ENOG4105WQI isochorismatase HEC78_RS15945 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HEC78_RS15950 ENOG4105E4F Isochorismate synthase HEC78_RS15955 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HEC78_RS15960 ENOG4105E8G Major facilitator Superfamily HEC78_RS15965 ENOG4105DQ5 transport system permease protein HEC78_RS15970 ENOG4105TVJ transport system, permease HEC78_RS15975 ENOG4105E0A ABC, transporter HEC78_RS15980 ENOG4108QY5 Ferric enterobactin transport protein HEC78_RS15985 ENOG4105C0W non-ribosomal peptide synthetase HEC78_RS15990 ENOG41085A6 mbth domain-containing protein HEC78_RS15995 ENOG4105E93 esterase HEC78_RS16000 ENOG4107RNH Outer membrane receptor FepA HEC78_RS16005 ENOG4108TSE Transferase HEC78_RS16015 ENOG4105WQ6 Membrane HEC78_RS16020 ENOG4105HFT AraC family transcriptional regulator HEC78_RS16025 ENOG41067SE Tetr family transcriptional regulator HEC78_RS16030 ENOG4105MSB protein, conserved in bacteria HEC78_RS16035 ENOG4108RCM Nitroreductase HEC78_RS16045 ENOG4105CUY Mechanosensitive ion channel HEC78_RS16050 ENOG4105C85 amino acid HEC78_RS16060 ENOG4108KBJ Inner membrane protein YkgB HEC78_RS16065 ENOG41066GK UPF0379 protein ykgI HEC78_RS16070 ENOG4107QN2 dihydrolipoyl dehydrogenase HEC78_RS16075 ENOG4108K01 transcriptional regulator HEC78_RS16095 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HEC78_RS16100 ENOG4105CKK Glycosyl transferase, family 2 HEC78_RS16125 ENOG4106KCD HTH_LUXR HEC78_RS16135 ENOG4106721 fimbriae Y protein HEC78_RS16140 ENOG4108Q9V regulatoR HEC78_RS16145 ENOG4108ZI2 Fimbrial protein HEC78_RS16150 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HEC78_RS16155 ENOG4105CW0 outer membrane usher protein HEC78_RS16160 ENOG4108AF8 Chaperone HEC78_RS16170 ENOG4108WDE Fimbrial protein HEC78_RS16180 ENOG4105WQ3 Rna-binding protein HEC78_RS16185 ENOG4105S2T inner membrane protein YbcI HEC78_RS16205 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HEC78_RS16215 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HEC78_RS16220 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HEC78_RS16225 ENOG4105C5B carbamate kinase HEC78_RS16230 ENOG4105G5A Protein of unknown function (DUF2877) HEC78_RS16235 ENOG4107REC cytoplasmic protein HEC78_RS16240 ENOG4107R1Q Membrane protein FdrA HEC78_RS16245 ENOG4105DG4 malate L-lactate dehydrogenase HEC78_RS16250 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HEC78_RS16255 ENOG4105S0E allantoin catabolism protein HEC78_RS16260 ENOG4105BZW Glycerate kinase HEC78_RS16265 ENOG4105DTE Xanthine uracil vitamin C permease HEC78_RS16275 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HEC78_RS16285 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEC78_RS16290 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HEC78_RS16295 ENOG41060W2 glyoxylate carboligase HEC78_RS16320 ENOG4108UMI ABC transporter, permease HEC78_RS16325 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEC78_RS16330 ENOG4105D01 (LipO)protein HEC78_RS16340 ENOG4105CV6 ABC transporter, permease HEC78_RS16345 ENOG4108I0Y (ABC) transporter HEC78_RS16350 ENOG4108UJV acyl-CoA thioesterase i HEC78_RS16355 ENOG4105E1F short-chain dehydrogenase reductase HEC78_RS16360 ENOG4107QR8 Thioredoxin HEC78_RS16365 ENOG4105C4B ABC transporter, permease HEC78_RS16370 ENOG41083J0 (ABC) transporter HEC78_RS16375 ENOG4107QX8 SPFH domain, Band 7 family protein HEC78_RS16380 ENOG4105G5H Membrane HEC78_RS16385 ENOG4108Z6Z Transcriptional regulator HEC78_RS16390 ENOG4105C59 p-type ATPase HEC78_RS16400 ENOG4105MBR gumn family HEC78_RS16405 ENOG4108Z66 YbaK ebsC protein HEC78_RS16410 ENOG4105CGH 5'-nucleotidase HEC78_RS16415 ENOG4105EU0 Major facilitator Superfamily HEC78_RS16420 ENOG4105CKD glutathione-regulated potassium-efflux system protein HEC78_RS16425 ENOG4107RE1 Inosine-guanosine kinase HEC78_RS16460 ENOG4107QMP dna polymerase iii subunits gamma and tau HEC78_RS16470 ENOG4105WD1 Membrane HEC78_RS16475 ENOG4108URS primosomal replication protein n'' HEC78_RS16480 ENOG4106428 Protein of unknown function (DUF2496) HEC78_RS16485 ENOG4105DNE Transposase HEC78_RS16490 ENOG4105EGS Mechanosensitive ion channel HEC78_RS16495 ENOG4107XI7 Tetr family transcriptional regulator HEC78_RS16500 ENOG4105C1P efflux transporter, rnd family, mfp subunit HEC78_RS16505 ENOG4105BZS acriflavin resistance protein HEC78_RS16510 ENOG4108UKR Biofilm formation regulator YbaJ HEC78_RS16520 ENOG4108UW5 maltose o-acetyltransferase HEC78_RS16525 ENOG4105GSJ Inner membrane protein ylaC HEC78_RS16540 ENOG41066DG (EAL) domain protein HEC78_RS16550 ENOG41080UX Methyltransferase HEC78_RS16555 ENOG4108MNP Glycoprotein polysaccharide metabolism HEC78_RS16560 ENOG4105C29 acyl-CoA thioesterase HEC78_RS16565 ENOG4105BZU Histidine kinase HEC78_RS16570 ENOG4108YZA Nitrogen regulatory protein pii HEC78_RS16575 ENOG4105BZ1 (ABC) transporter HEC78_RS16580 ENOG4105BZ1 (ABC) transporter HEC78_RS16585 ENOG4108XM1 transcriptional regulator AsnC family HEC78_RS16600 ENOG4108NFA extracellular solute-binding protein HEC78_RS16610 ENOG4108TGP Thioesterase superfamily protein HEC78_RS16615 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HEC78_RS16620 ENOG4105EIN peptidylprolyl cis-trans isomerase HEC78_RS16625 ENOG4105K70 DNA-binding protein HEC78_RS16630 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HEC78_RS16650 ENOG4105M85 Bola protein HEC78_RS16655 ENOG4105IEY (LipO)protein HEC78_RS16660 ENOG4105EYM Major Facilitator superfamily HEC78_RS16665 ENOG4105E2S oxidase) subunit II HEC78_RS16670 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEC78_RS16675 ENOG4105CCU oxidase (Subunit III) HEC78_RS16680 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HEC78_RS16705 ENOG4107RDB Major Facilitator HEC78_RS16715 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEC78_RS16720 ENOG4107S0N DJ-1 family HEC78_RS16735 ENOG4106S9K Transcriptional regulator HEC78_RS16745 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEC78_RS16750 ENOG4108MP3 ABC transporter, permease HEC78_RS16755 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HEC78_RS16765 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEC78_RS16770 ENOG4105CTB Polyprenyl synthetase HEC78_RS16780 ENOG4105CPC Aldo Keto reductase HEC78_RS16785 ENOG4108ZAI phosphatidylglycerophosphatase a HEC78_RS16790 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HEC78_RS16795 ENOG4107YIM Involved in the transcription termination process (By similarity) HEC78_RS16805 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HEC78_RS16815 ENOG4108KIC (LipO)protein HEC78_RS16820 ENOG4105DRB nucleoside-specific channel-forming protein HEC78_RS16830 ENOG4105N1F Hnh endonuclease HEC78_RS16845 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEC78_RS16855 ENOG4105VIE preprotein translocase, subunit YajC HEC78_RS16875 ENOG4105D3R alkyl hydroperoxide reductase HEC78_RS16885 ENOG4107R28 alpha amylase, catalytic region HEC78_RS16890 ENOG4105C85 amino acid HEC78_RS16895 ENOG4105CWM branched-chain amino acid transport system II carrier protein HEC78_RS16900 ENOG4105BZU Histidine kinase HEC78_RS16905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEC78_RS16910 ENOG4107RH8 nuclease SbcCD subunit D HEC78_RS16915 ENOG4105EYH Exonuclease HEC78_RS16920 ENOG4105F27 Major Facilitator HEC78_RS16925 ENOG4105DKQ ROK family HEC78_RS16940 ENOG4105HBA AroM protein HEC78_RS16945 ENOG4105SS3 HEC78_RS16960 ENOG4105II7 pyrroline-5-carboxylate reductase HEC78_RS16965 ENOG4105BZU Histidine kinase HEC78_RS16970 ENOG4105VIF phosphate starvation-inducible protein HEC78_RS16990 ENOG4105CPF Cell wall formation (By similarity) HEC78_RS16995 ENOG4105UNH Membrane HEC78_RS17000 ENOG4105FR5 inner membrane protein YaiY HEC78_RS17005 ENOG4107QS8 (LipO)protein HEC78_RS17010 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HEC78_RS17015 ENOG4107R6D beta-lactam binding protein AmpH HEC78_RS17020 ENOG4108PNB DNA-binding transcriptional regulator HEC78_RS17025 ENOG4108NSE outer membrane autotransporter barrel HEC78_RS17030 ENOG4105D52 delta-aminolevulinic acid dehydratase HEC78_RS17035 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEC78_RS17040 ENOG4105DXD 2-methylcitrate dehydratase HEC78_RS17045 ENOG4105BZN citrate synthase HEC78_RS17050 ENOG4105CR4 methylisocitrate lyase HEC78_RS17055 ENOG4108JU7 Transcriptional regulator HEC78_RS17060 ENOG4105TDT uncharacterized protein yahO HEC78_RS17065 ENOG4105E82 cytochrome subunit of dehydrogenase HEC78_RS17085 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEC78_RS17090 ENOG4105C4M (Ubiquinol oxidase) subunit I HEC78_RS17100 ENOG4105D8D Type III HEC78_RS17105 ENOG4107QMH DNA methylase HEC78_RS17110 ENOG4105JHE Major Facilitator Superfamily HEC78_RS17140 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HEC78_RS17160 ENOG4108T1M outer membrane protein x HEC78_RS17175 ENOG4107XTP (EAL) domain protein HEC78_RS17190 ENOG4105X0I Fimbrial HEC78_RS17195 ENOG4108VEV chaperone HEC78_RS17200 ENOG4105CW0 outer membrane usher protein HEC78_RS17220 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HEC78_RS17225 ENOG4105CKK Glycosyl transferase, family 2 HEC78_RS17335 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HEC78_RS17340 ENOG4105KUS lysozyme HEC78_RS17350 ENOG4105HGD Antitermination protein HEC78_RS17395 ENOG4105NY2 NinB protein HEC78_RS17405 ENOG4105CDU Replicative dna helicase HEC78_RS17490 ENOG4105VIZ double-strand break repair protein HEC78_RS17510 ENOG41077V0 CPS-53 (KpLE1) prophage HEC78_RS17545 ENOG4108KU3 Integrase HEC78_RS17560 ENOG4105PTU response to oxidative stress HEC78_RS17680 ENOG4107ZQ5 Phage-associated protein, HI1409 family HEC78_RS17685 ENOG4108N0N Phage Terminase Large Subunit HEC78_RS17705 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HEC78_RS17730 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HEC78_RS17735 ENOG4105NY2 NinB protein HEC78_RS17770 ENOG4105CDU Replicative dna helicase HEC78_RS17795 ENOG4105KT5 UmuD protein HEC78_RS17870 ENOG4105KSC Transcriptional regulator, TraR DksA family HEC78_RS17880 ENOG4108KU3 Integrase HEC78_RS17900 ENOG4105FCK Membrane HEC78_RS17915 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HEC78_RS17920 ENOG4105CIN aminoacyl-histidine dipeptidase HEC78_RS17925 ENOG4108S2Y peptide Chain Release factor HEC78_RS17940 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HEC78_RS17945 ENOG4105E7A Glutamine amidotransferase HEC78_RS17960 ENOG4107QPN acyl-Coa dehydrogenase HEC78_RS17965 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HEC78_RS17975 ENOG4105T40 surface antigen msp4 family protein HEC78_RS17995 ENOG4108XM1 transcriptional regulator AsnC family HEC78_RS18035 ENOG4105W7K Transcriptional regulator HEC78_RS18125 ENOG4105CS6 Rhs element vgr protein HEC78_RS18225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC78_RS18265 ENOG4107RZZ dna polymerase iii epsilon subunit HEC78_RS18270 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HEC78_RS18275 ENOG4105D1A Methyltransferase HEC78_RS18285 ENOG4105E9H Lytic Murein transglycosylase HEC78_RS18290 ENOG4105F2W methyltransferase HEC78_RS18300 ENOG4105F27 Major Facilitator HEC78_RS18305 ENOG4105HEI LysR family (Transcriptional regulator HEC78_RS18310 ENOG4105CV8 reductase HEC78_RS18345 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HEC78_RS18350 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEC78_RS18355 ENOG4108UMI ABC transporter, permease HEC78_RS18360 ENOG4105D01 (LipO)protein HEC78_RS18365 ENOG4108R8X outer membrane lipoprotein HEC78_RS18370 ENOG4108R96 Methyltransferase, YaeB family HEC78_RS18380 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HEC78_RS18385 ENOG4108YZN class I peptide chain release factor HEC78_RS18390 ENOG4108VWS Yaeq family HEC78_RS18400 ENOG4105M1T rho-binding antiterminator HEC78_RS18410 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HEC78_RS18415 ENOG4105CXN decarboxylase HEC78_RS18420 ENOG4108M1A Chitin-binding protein HEC78_RS18430 ENOG4105C0B DNA polymerase III (alpha subunit) HEC78_RS18450 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HEC78_RS18455 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HEC78_RS18460 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HEC78_RS18475 ENOG4105KNE Phosphatidate cytidylyltransferase HEC78_RS18490 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HEC78_RS18495 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HEC78_RS18505 ENOG4105CE9 30S ribosomal protein S2 HEC78_RS18510 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HEC78_RS18525 ENOG4105CSH Transporter HEC78_RS18535 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HEC78_RS18540 ENOG4105C0H protease HEC78_RS18555 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HEC78_RS18560 ENOG4105EN6 Membrane HEC78_RS18565 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HEC78_RS18580 ENOG4106RDH Protein of unknown function (DUF2544) HEC78_RS18590 ENOG4105UGQ Fimbrial HEC78_RS18595 ENOG4105NEV Fimbrial HEC78_RS18600 ENOG4108FZ9 Chaperone HEC78_RS18605 ENOG4106PG1 outer membrane usher protein HEC78_RS18615 ENOG4105S6R Iron-hydroxamate transporter permease subunit HEC78_RS18620 ENOG4105J76 Periplasmic binding protein HEC78_RS18625 ENOG4105E0A ABC, transporter HEC78_RS18630 ENOG4105E0K tonB-dependent siderophore receptor HEC78_RS18635 ENOG4105BZ4 penicillin-binding protein HEC78_RS18640 ENOG4105CQ7 ATP-dependent helicase HEC78_RS18645 ENOG4107XID 2'-5' rna ligase HEC78_RS18655 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HEC78_RS18660 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HEC78_RS18665 ENOG4105DJ0 Poly(A) Polymerase HEC78_RS18670 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HEC78_RS18695 ENOG4108VEV chaperone HEC78_RS18700 ENOG4105CW0 outer membrane usher protein HEC78_RS18705 ENOG4108XEY fimbrial-like adhesin protein HEC78_RS18725 ENOG4107BJW polysaccharide deacetylase HEC78_RS18730 ENOG4108YTN IIa component HEC78_RS18735 ENOG4105E3A (ABC) transporter HEC78_RS18740 ENOG4105DA5 (ABC) transporter HEC78_RS18745 ENOG41077A9 carbonic anhydrase HEC78_RS18750 ENOG4108UGV hypoxanthine phosphoribosyltransferase HEC78_RS18755 ENOG4105DZG Dehydrogenase HEC78_RS18760 ENOG4105E3B Multicopper oxidase HEC78_RS18765 ENOG4108ZRK uncharacterized protein yacC HEC78_RS18780 ENOG4105MVE transcriptional regulator HEC78_RS18785 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HEC78_RS18790 ENOG4107S2N Type III effector Hrp-dependent HEC78_RS18795 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HEC78_RS18805 ENOG4107QIJ Aconitate hydratase 2 HEC78_RS18810 ENOG4108NST exported protein HEC78_RS18825 ENOG4107QN2 dihydrolipoyl dehydrogenase HEC78_RS18830 ENOG4107QSN dihydrolipoamide acetyltransferase HEC78_RS18835 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEC78_RS18850 ENOG4105CT4 transporter HEC78_RS18855 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HEC78_RS18860 ENOG4106A72 regulatory protein AmpE HEC78_RS18870 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HEC78_RS18875 ENOG4108ZUW Major pilin subunit HEC78_RS18880 ENOG4107QHF type ii secretion system protein e HEC78_RS18885 ENOG4105D7Q type ii secretion system HEC78_RS18895 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HEC78_RS18905 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HEC78_RS18920 ENOG4105M6F mutator MutT protein HEC78_RS18940 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HEC78_RS18945 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HEC78_RS18950 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HEC78_RS18970 ENOG4105CNI cell division protein FtsW HEC78_RS18980 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HEC78_RS18985 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HEC78_RS18995 ENOG4105CJN penicillin-binding protein HEC78_RS19000 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HEC78_RS19015 ENOG4107B7Y DNA-binding transcriptional regulator FruR HEC78_RS19020 ENOG4108ZP8 Acetolactate synthase small subunit HEC78_RS19025 ENOG4105C7K acetolactate synthase HEC78_RS19030 ENOG41064T2 transcriptional regulator, lysR family HEC78_RS19050 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEC78_RS19090 ENOG4108KF1 Membrane HEC78_RS19095 ENOG41063TF transcriptional regulator (AraC HEC78_RS19110 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HEC78_RS19130 ENOG4105CQ2 DNA polymerase HEC78_RS19140 ENOG4105D3G Pseudouridine synthase HEC78_RS19150 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HEC78_RS19160 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HEC78_RS19170 ENOG4105NWN ApaG protein HEC78_RS19210 ENOG4105M5B (LipO)protein HEC78_RS19215 ENOG4105C54 Major Facilitator superfamily HEC78_RS19220 ENOG4105WQV ferredoxin-like protein HEC78_RS19225 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HEC78_RS19270 ENOG4108XNW Transcriptional activatory protein CaiF HEC78_RS19275 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HEC78_RS19280 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HEC78_RS19305 ENOG4105CHY citrate lyase, alpha HEC78_RS19310 ENOG4105CI0 Citrate lyase HEC78_RS19320 ENOG4105DUA (citrate (pro-3S)-lyase ligase HEC78_RS19335 ENOG4107QSA Oxaloacetate decarboxylase HEC78_RS19340 ENOG4105D9Q decarboxylase (Beta subunit) HEC78_RS19345 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEC78_RS19350 ENOG4106YYS transcriptional regulatory protein HEC78_RS19370 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HEC78_RS19385 ENOG4105DTN riboflavin biosynthesis protein ribF HEC78_RS19390 ENOG410647N response to DNA damage stimulus HEC78_RS19410 ENOG41063Z6 transcriptional regulator, lysR family HEC78_RS19430 ENOG4105C4X radical SAM domain protein HEC78_RS19435 ENOG41061MV Arylsulfatase HEC78_RS19445 ENOG4105CGH 5'-nucleotidase HEC78_RS19480 ENOG4106PH7 chaperone HEC78_RS19495 ENOG4105MHR Fimbrial protein HEC78_RS19500 ENOG4105CW0 outer membrane usher protein HEC78_RS19505 ENOG4108AF8 Chaperone HEC78_RS19510 ENOG4108RQP Major type 1 subunit fimbrin HEC78_RS19560 ENOG4108WTA UPF0412 protein YaaI HEC78_RS19565 ENOG4108QUJ UPF0174 protein YaaW HEC78_RS19570 ENOG4106HK8 GPR1 FUN34 yaaH family protein HEC78_RS19575 ENOG4108RIR Molybdenum cofactor biosynthesis protein HEC78_RS19580 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEC78_RS19585 ENOG4105BZG amino acid carrier protein HEC78_RS19595 ENOG4105D98 threonine synthase HEC78_RS19605 ENOG4105CFH Aspartokinase HEC78_RS19615 ENOG4106FVC RNA methyltransferase HEC78_RS19620 ENOG410759A HEC78_RS19625 ENOG41065U4 response regulator HEC78_RS19635 ENOG4108PNB DNA-binding transcriptional regulator HEC78_RS19645 ENOG4108VCD Chaperone HEC78_RS19650 ENOG4105CW0 outer membrane usher protein HEC78_RS19665 ENOG4105CT7 inner membrane cred family protein HEC78_RS19670 ENOG4105EB3 Histidine kinase HEC78_RS19675 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC78_RS19680 ENOG4108RH0 Crea protein HEC78_RS19685 ENOG4105UEI Transcriptional Regulator AraC Family HEC78_RS19705 ENOG4107SC1 transglycosylase HEC78_RS19710 ENOG4105C5H ABC transporter HEC78_RS19715 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HEC78_RS19720 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HEC78_RS19725 ENOG4105EAC phosphoserine phosphatase HEC78_RS19730 ENOG41062Z9 Membrane HEC78_RS19765 ENOG4105G0K glycine radical enzyme YjjI family HEC78_RS19770 ENOG41076CZ activating enzyme HEC78_RS19775 ENOG4105EYA deoxyribonuclease HEC78_RS19780 ENOG4108NRW Phospholipase, patatin family HEC78_RS19790 ENOG4105K3G Periplasmic Protein HEC78_RS19800 ENOG4105PAD Hydrolase HEC78_RS19805 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HEC78_RS19810 ENOG4108WPU DNA polymerase III subunit psi HEC78_RS19835 ENOG4105YBH Protein of unknown function (DUF1435) HEC78_RS19840 ENOG4105BZU Histidine kinase HEC78_RS19845 ENOG4108819 ferric iron reductase HEC78_RS19850 ENOG4108UIN ybak prolyl-trna synthetase associated region HEC78_RS19855 ENOG4108T94 DNA-binding transcriptional activator BglJ HEC78_RS19860 ENOG4108N8T regulatoR HEC78_RS19865 ENOG4105DWK Membrane HEC78_RS19880 ENOG4106CVF DNA replication protein HEC78_RS19885 ENOG4105RI1 glycoprotein receptor HEC78_RS19895 ENOG4105C8Q Methyl-accepting chemotaxis HEC78_RS19900 ENOG4105D22 carbon starvation protein HEC78_RS19905 ENOG4105VCD cytoplasmic protein HEC78_RS19910 ENOG4105CKI cobalamin synthesis protein HEC78_RS19915 ENOG41063TF transcriptional regulator (AraC HEC78_RS19920 ENOG4105E82 cytochrome subunit of dehydrogenase HEC78_RS19925 ENOG4108HFV HEC78_RS19940 ENOG4105C26 Dehydrogenase HEC78_RS19945 ENOG4105DNE Transposase HEC78_RS19950 ENOG41083G8 Multidrug resistance protein MdtM HEC78_RS19955 ENOG4106BRA Membrane HEC78_RS19960 ENOG4105CBP Major Facilitator HEC78_RS19965 ENOG41074DU domain protein HEC78_RS19970 ENOG4108P2H Inner membrane protein YjiG HEC78_RS19975 ENOG4105DYB Isoaspartyl dipeptidase HEC78_RS19980 ENOG4107YNJ LysR family Transcriptional regulator HEC78_RS20000 ENOG4105C6F GntR Family Transcriptional Regulator HEC78_RS20020 ENOG4105KZM cytoplasmic protein HEC78_RS20030 ENOG4105DTA methyltransferase HEC78_RS20080 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC78_RS20100 ENOG4105C0D helicase HEC78_RS20115 ENOG4107QMH DNA methylase HEC78_RS20135 ENOG4105DQ4 alcohol dehydrogenase HEC78_RS20140 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEC78_RS20145 ENOG4105CPQ Dehydrogenase HEC78_RS20150 ENOG4105CHR reductase HEC78_RS20155 ENOG4105C6Z Gluconate HEC78_RS20160 ENOG4105K2J Transcriptional regulator HEC78_RS20165 ENOG4108K5H permease YjgP YjgQ family protein HEC78_RS20170 ENOG4108M8S permease YjgP YjgQ family protein HEC78_RS20180 ENOG4105MYG DNA polymerase iii, chi subunit HEC78_RS20185 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HEC78_RS20190 ENOG4108M3P Membrane HEC78_RS20195 ENOG4108MJ3 acetyltransferase HEC78_RS20210 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HEC78_RS20215 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HEC78_RS20220 ENOG4105DBV ornithine carbamoyltransferase HEC78_RS20225 ENOG4105XEP YhcH YjgK YiaL family protein HEC78_RS20230 ENOG4105CEU Arginine dihydrolase HEC78_RS20235 ENOG4105C5B carbamate kinase HEC78_RS20240 ENOG4105DBV ornithine carbamoyltransferase HEC78_RS20245 ENOG4105CSX c4-dicarboxylate anaerobic carrier HEC78_RS20250 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HEC78_RS20260 ENOG41077AM PyrBI operon attenuator HEC78_RS20275 ENOG4105KME endoribonuclease L-psp HEC78_RS20290 ENOG4105D4X repressor HEC78_RS20295 ENOG4105C5Y PTS System HEC78_RS20300 ENOG4105CG3 alpha amylase, catalytic region HEC78_RS20305 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HEC78_RS20310 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HEC78_RS20315 ENOG4105K4U addiction module toxin, RelE StbE family HEC78_RS20325 ENOG4105EMD TRANSCRIPTIONal HEC78_RS20340 ENOG41069H0 dihydroorotase EC 3.5.2.3 HEC78_RS20370 ENOG4108XVM Cytochrome b(562) HEC78_RS20375 ENOG4105CMS peptidase U62, modulator of DNA gyrase HEC78_RS20385 ENOG4105F0H myo-inositol catabolism protein HEC78_RS20395 ENOG4105IE8 Alpha-ketoglutarate permease HEC78_RS20400 ENOG4105CK5 oxidoreductase HEC78_RS20405 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEC78_RS20410 ENOG4105D7K pfkb domain protein HEC78_RS20420 ENOG4107VG4 Xylose isomerase domain protein TIM barrel HEC78_RS20425 ENOG4108MYR Secreted protein HEC78_RS20450 ENOG4105C26 Dehydrogenase HEC78_RS20455 ENOG4105DH8 myo-inositol catabolism HEC78_RS20460 ENOG4107QNK )-transporter HEC78_RS20465 ENOG4107QNK )-transporter HEC78_RS20470 ENOG4105CHC glucokinase (EC 2.7.1.2) HEC78_RS20475 ENOG4105DFU Cell wall formation (By similarity) HEC78_RS20485 ENOG4105F0N pyrophosphate phospho-hydrolase HEC78_RS20490 ENOG41069H0 dihydroorotase EC 3.5.2.3 HEC78_RS20495 ENOG4105DJB Major Facilitator Superfamily HEC78_RS20500 ENOG4108ZHD aig2 family HEC78_RS20520 ENOG4105C37 (CBS) domain HEC78_RS20525 ENOG41061GZ Protein of unknown function (DUF1107) HEC78_RS20530 ENOG4108UUE Transcriptional regulator HEC78_RS20535 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HEC78_RS20540 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HEC78_RS20545 ENOG4105KVH Transcriptional regulator HEC78_RS20550 ENOG4105ECR NmrA family HEC78_RS20555 ENOG4105DXC membrane HEC78_RS20570 ENOG4108V1T peptidylprolyl cis-trans isomerase HEC78_RS20575 ENOG4105FHY Opacity-associated protein A HEC78_RS20585 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HEC78_RS20590 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEC78_RS20595 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HEC78_RS20600 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HEC78_RS20610 ENOG4105KIT UPF0379 protein yjfY HEC78_RS20640 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HEC78_RS20655 ENOG4108MXZ Esterase HEC78_RS20660 ENOG4105WSB biofilm stress and motility protein A HEC78_RS20665 ENOG4105S17 UPF0379 protein yjfN HEC78_RS20670 ENOG4105CSU acyl-Coa dehydrogenase HEC78_RS20675 ENOG4106032 Glutathionylspermidine synthase HEC78_RS20680 ENOG4108KXT Conserved Protein HEC78_RS20685 ENOG4105Z6B inner membrane protein yjfl HEC78_RS20690 ENOG4107VNS Protein of unknown function (DUF2491) HEC78_RS20695 ENOG4108P9J Phage shock protein A HEC78_RS20700 ENOG4105FUX Conserved Protein HEC78_RS20705 ENOG4105C2N RNA methyltransferase TrmH family group 3 HEC78_RS20710 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HEC78_RS20730 ENOG4105EPW hflc protein HEC78_RS20735 ENOG4107QJR hflk protein HEC78_RS20740 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HEC78_RS20745 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HEC78_RS20760 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HEC78_RS20765 ENOG4105K8N protein family UPF0079, ATPase HEC78_RS20770 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HEC78_RS20775 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HEC78_RS20790 ENOG4106TNF Periplasmic binding protein HEC78_RS20795 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HEC78_RS20810 ENOG4105EGS Mechanosensitive ion channel HEC78_RS20815 ENOG4106CG8 Inner membrane protein YjeO HEC78_RS20820 ENOG4107SC7 Inner membrane transporter yjeM HEC78_RS20830 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEC78_RS20835 ENOG4105E33 succinate dehydrogenase HEC78_RS20845 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HEC78_RS20855 ENOG4105KPY Small multidrug resistance protein HEC78_RS20865 ENOG4106BSU Entericidin B HEC78_RS20875 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HEC78_RS20880 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HEC78_RS20885 ENOG4105MTB Uncharacterized protein YjeJ HEC78_RS20890 ENOG4108ZVF (LipO)protein HEC78_RS20905 ENOG4105DVH amino acid HEC78_RS20910 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HEC78_RS20915 ENOG4108IJ0 Aspartate ammonia-lyase HEC78_RS20920 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HEC78_RS20935 ENOG4108SIC Transcriptional regulator HEC78_RS20950 ENOG4105SBG acid phosphatase HEC78_RS20980 ENOG41068CG regulatoR HEC78_RS20995 ENOG4108ZK4 sdia-regulated domain-containing protein HEC78_RS21005 ENOG4108NEM leader-binding protein dmsD HEC78_RS21010 ENOG4107KGK dmso reductase anchor subunit HEC78_RS21015 ENOG4105QAX Iron-sulfur HEC78_RS21020 ENOG4107QY8 reductase HEC78_RS21025 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEC78_RS21030 ENOG4108MRH transcriptional regulatory protein HEC78_RS21040 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HEC78_RS21045 ENOG4107GFK fumarate HEC78_RS21050 ENOG4105CT4 transporter HEC78_RS21055 ENOG4105F8D glycoside hydrolase family 4 HEC78_RS21060 ENOG4108K2B transcriptional regulator HEC78_RS21065 ENOG4105CXN decarboxylase HEC78_RS21070 ENOG4106ZGR Transcriptional regulator HEC78_RS21075 ENOG4105D5Q Arginine ornithine antiporter HEC78_RS21080 ENOG4105DIJ Phosphoethanolamine transferase HEC78_RS21085 ENOG4105XJC Two component transcriptional regulator (Winged helix family HEC78_RS21090 ENOG4105ECM Sensor protein basS pmrB HEC78_RS21100 ENOG4105CSH Transporter HEC78_RS21105 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HEC78_RS21110 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HEC78_RS21115 ENOG410870W N-acetyltransferase HEC78_RS21130 ENOG41082ND Uncharacterized protein yjcO HEC78_RS21140 ENOG4105CK2 sodium dicarboxylate symporter HEC78_RS21145 ENOG4108W0S formate-dependent nitrite reductase complex HEC78_RS21155 ENOG4108QKW cytochrome c-type biogenesis protein HEC78_RS21160 ENOG4105DVI reductase, NrfD HEC78_RS21165 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC78_RS21170 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HEC78_RS21180 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEC78_RS21185 ENOG41062QD Membrane HEC78_RS21195 ENOG41067MG lrgb family HEC78_RS21205 ENOG4105CMU LysR family (Transcriptional regulator HEC78_RS21210 ENOG4105EEQ Na H antiporter HEC78_RS21215 ENOG4105C7N Xanthine uracil vitamin C permease HEC78_RS21225 ENOG4108Z4X TRANSCRIPTIONal HEC78_RS21230 ENOG4108W3Q Transcriptional regulator HEC78_RS21235 ENOG4108M8H domain protein HEC78_RS21240 ENOG4105PMV Membrane HEC78_RS21280 ENOG4108UUM single-stranded DNA-binding protein HEC78_RS21285 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEC78_RS21300 ENOG4105MSB protein, conserved in bacteria HEC78_RS21305 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HEC78_RS21310 ENOG4105F0S class B acid phosphatase HEC78_RS21315 ENOG4105CGF Aromatic amino acid aminotransferase HEC78_RS21320 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEC78_RS21325 ENOG4105CDU Replicative dna helicase HEC78_RS21330 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEC78_RS21335 ENOG4105P4Z Phage shock protein G HEC78_RS21340 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HEC78_RS21350 ENOG4105MYN Zinc uptake regulation protein HEC78_RS21355 ENOG4105VDW Csbd family HEC78_RS21365 ENOG4107R73 Mate efflux family protein HEC78_RS21370 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEC78_RS21375 ENOG41080IJ Diacylglycerol kinase HEC78_RS21395 ENOG4107W52 maltose operon periplasmic protein HEC78_RS21405 ENOG4108IJ9 (ABC) transporter HEC78_RS21410 ENOG4107FKK extracellular solute-binding protein family 1 HEC78_RS21415 ENOG4105D56 permease protein HEC78_RS21420 ENOG4105EG2 ABC transporter, permease HEC78_RS21430 ENOG4105E3R (LipO)protein HEC78_RS21435 ENOG4108Q9C Periplasmic Protein HEC78_RS21440 ENOG4108MDC (LipO)protein HEC78_RS21455 ENOG4105CFH Aspartokinase HEC78_RS21470 ENOG410667J hydrolase HEC78_RS21475 ENOG4105E98 transcriptional regulator DeoR family HEC78_RS21480 ENOG4108ZR5 Conserved Protein HEC78_RS21485 ENOG4105FE9 pseudouridine synthase HEC78_RS21490 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HEC78_RS21505 ENOG4105EAM Na Pi-cotransporter HEC78_RS21510 ENOG4105C3R Methionine synthase HEC78_RS21515 ENOG41069M3 Transcriptional regulator HEC78_RS21530 ENOG4108I9X Isocitrate lyase HEC78_RS21535 ENOG4107QP3 malate synthase g HEC78_RS21545 ENOG4105K5X acetyltransferase HEC78_RS21570 ENOG4105DC1 bifunctional purine biosynthesis protein purh HEC78_RS21575 ENOG4105C12 Phosphoribosylglycinamide synthetase HEC78_RS21580 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC78_RS21585 ENOG4105BZU Histidine kinase HEC78_RS21595 ENOG4108T8B Protein of unknown function (DUF1481) HEC78_RS21600 ENOG4105K70 DNA-binding protein HEC78_RS21605 ENOG4105R2J Conserved Protein HEC78_RS21640 ENOG4105D06 uba thif-type nad fad binding protein HEC78_RS21645 ENOG4105WHD thiamine biosynthesis protein ThiS HEC78_RS21655 ENOG4105D41 biosynthesis protein thiH HEC78_RS21675 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEC78_RS21680 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEC78_RS21685 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEC78_RS21690 ENOG4108VZM 50s ribosomal protein L10 HEC78_RS21705 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HEC78_RS21710 ENOG4105PM1 preprotein translocase subunit SecE HEC78_RS21715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEC78_RS21750 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HEC78_RS21755 ENOG4105D4A Cell wall formation (By similarity) HEC78_RS21800 ENOG4108Y73 Membrane HEC78_RS21815 ENOG4105C5Q Transcriptional regulator HEC78_RS21850 ENOG4105DIJ Phosphoethanolamine transferase HEC78_RS21855 ENOG4106R3P AraC family transcriptional regulator HEC78_RS21865 ENOG4105DCT glycerol dehydrogenase HEC78_RS21870 ENOG4108XC3 NADH ubiquinone oxidoreductase HEC78_RS21880 ENOG4105SYT Methylenetetrahydrofolate reductase HEC78_RS21890 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEC78_RS21895 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEC78_RS21900 ENOG4105CGH 5'-nucleotidase HEC78_RS21915 ENOG4105D64 Mechanosensitive ion channel HEC78_RS21920 ENOG4105CFH Aspartokinase HEC78_RS21925 ENOG4105C28 cystathionine HEC78_RS21935 ENOG4108MR7 Arylsulfotransferase HEC78_RS21950 ENOG4105C25 Primosomal protein n' HEC78_RS21955 ENOG4105ETE Transcriptional regulator (LacI family HEC78_RS21960 ENOG41063M6 Cell Division Protein HEC78_RS21975 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HEC78_RS21990 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEC78_RS22000 ENOG4105CBT Fructose-1,6-bisphosphatase HEC78_RS22005 ENOG4105DP0 ferredoxin-NADP reductase HEC78_RS22010 ENOG4108VTS Membrane HEC78_RS22015 ENOG4105EBK exported protein HEC78_RS22040 ENOG4105D7K pfkb domain protein HEC78_RS22045 ENOG4105CT4 transporter HEC78_RS22055 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HEC78_RS22060 ENOG4105CTQ phosphohexokinase HEC78_RS22070 ENOG4105FMW periplasmic HEC78_RS22075 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC78_RS22080 ENOG4105E0F Histidine kinase HEC78_RS22090 ENOG4108RPX mosc domain containing protein HEC78_RS22095 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEC78_RS22100 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HEC78_RS22105 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HEC78_RS22110 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HEC78_RS22115 ENOG4108QGT oligogalacturonate-specific porin HEC78_RS22140 ENOG4105DKG l-rhamnose isomerase HEC78_RS22150 ENOG4105C0A alcohol dehydrogenase HEC78_RS22165 ENOG4108UMN azlc family HEC78_RS22175 ENOG4108V87 frv operon regulatory protein HEC78_RS22180 ENOG4108V87 frv operon regulatory protein HEC78_RS22195 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC78_RS22200 ENOG4108MG3 formate dehydrogenase HEC78_RS22215 ENOG41068KX affects formate dehydrogenase-N HEC78_RS22225 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HEC78_RS22230 ENOG4108Z3N Transcriptional regulator HEC78_RS22235 ENOG4105SUU thioesterase domain HEC78_RS22250 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HEC78_RS22255 ENOG4105E98 transcriptional regulator DeoR family HEC78_RS22260 ENOG4108MGF sugar kinase HEC78_RS22265 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEC78_RS22270 ENOG4105D2M Aldolase HEC78_RS22275 ENOG4107QKS N-acylglucosamine 2-epimerase HEC78_RS22280 ENOG4107WI4 Aldose-1-epimerase HEC78_RS22285 ENOG4105CJQ hydrolase, family 31 HEC78_RS22290 ENOG4105CT4 transporter HEC78_RS22295 ENOG4105CT4 transporter HEC78_RS22300 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HEC78_RS22330 ENOG4108K4B hydrolase HEC78_RS22335 ENOG4105CI3 gtp-binding protein typa HEC78_RS22340 ENOG4105C5F glutamine synthetase HEC78_RS22345 ENOG4105CUX Signal transduction histidine kinase HEC78_RS22350 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC78_RS22355 ENOG4106FIY HEC78_RS22360 ENOG4105D4P Coproporphyrinogen iii oxidase HEC78_RS22380 ENOG4105C2M dna polymerase I HEC78_RS22385 ENOG4106HNH Acyl-transferase HEC78_RS22390 ENOG4108Z33 Thiol disulfide Interchange Protein HEC78_RS22400 ENOG4105PC1 Conserved Protein HEC78_RS22405 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HEC78_RS22410 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HEC78_RS22445 ENOG4108RR8 protoporphyrinogen oxidase HEC78_RS22450 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HEC78_RS22455 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HEC78_RS22470 ENOG4105CHU acetyl-coa acetyltransferase HEC78_RS22475 ENOG4108MR7 Arylsulfotransferase HEC78_RS22480 ENOG4107QK7 reductase HEC78_RS22485 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEC78_RS22490 ENOG4105MDZ Transcriptional activator rfaH HEC78_RS22495 ENOG4105F8V Hydrolase, tatD family HEC78_RS22500 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HEC78_RS22505 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HEC78_RS22510 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEC78_RS22520 ENOG4105JC1 sterol-binding domain protein HEC78_RS22530 ENOG4105CGY Dna recombination protein HEC78_RS22535 ENOG4107SXA Phosphorylase HEC78_RS22540 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HEC78_RS22545 ENOG4105C4X radical SAM domain protein HEC78_RS22555 ENOG4105DZ2 Transcriptional regulator HEC78_RS22560 ENOG4105EMK carboxylate amino acid amine transporter HEC78_RS22565 ENOG4105DQF Hydrolase HEC78_RS22570 ENOG4108EUD Lysophospholipase HEC78_RS22575 ENOG410829K Lysine exporter protein (Lyse ygga) HEC78_RS22580 ENOG4105CCF Lysine exporter protein (Lyse ygga) HEC78_RS22585 ENOG4105C9U ATP-dependent DNA helicase RecQ HEC78_RS22590 ENOG4105HDD phospholipase HEC78_RS22595 ENOG4108VUY thioesterase Superfamily protein HEC78_RS22600 ENOG4105FR1 rard protein HEC78_RS22615 ENOG4107QUT magnesium and cobalt transport protein CorA HEC78_RS22620 ENOG4105C4R Atp-dependent dna helicase HEC78_RS22625 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HEC78_RS22630 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC78_RS22635 ENOG4105CT0 Protein of unknown function, DUF484 HEC78_RS22645 ENOG4105S7Z (LipO)protein HEC78_RS22670 ENOG4107T0K Adenylate cyclase HEC78_RS22680 ENOG41076E6 Uroporphyrinogen-III Synthase HEC78_RS22685 ENOG4105ECF c-methyltransferase HEC78_RS22690 ENOG410601J HemY protein HEC78_RS22695 ENOG4108RS6 transposase HEC78_RS22720 ENOG4105C85 amino acid HEC78_RS22740 ENOG4105EGZ biosynthesis protein HEC78_RS22745 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HEC78_RS22750 ENOG4108WJ1 acetyltransferase HEC78_RS22755 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HEC78_RS22755 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HEC78_RS22760 ENOG4105C1B dTDP-glucose 4-6-dehydratase HEC78_RS22765 ENOG4108IJ1 Dehydrogenase HEC78_RS22770 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HEC78_RS22775 ENOG4105SFE lipopolysaccharide biosynthesis protein HEC78_RS22780 ENOG4105ESV Glycosyl transferase, family 4 HEC78_RS22785 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HEC78_RS22810 ENOG4105C4R Atp-dependent dna helicase HEC78_RS22820 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HEC78_RS22830 ENOG4105EMY transcriptional regulator HEC78_RS22850 ENOG4105C7B Threonine dehydratase HEC78_RS22860 ENOG4105CM2 brancheD-chain amino acid aminotransferase HEC78_RS22865 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HEC78_RS22880 ENOG4105C0P Mg chelatase subunit ChlI HEC78_RS22925 ENOG4107EJG GntR family transcriptional regulator HEC78_RS22930 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC78_RS22935 ENOG4105ETE Transcriptional regulator (LacI family HEC78_RS22940 ENOG4108RVA ribokinase HEC78_RS22945 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEC78_RS22950 ENOG4105CNN ABC, transporter HEC78_RS22985 ENOG4108VVK transcriptional Regulator, AsnC HEC78_RS22990 ENOG4105QTB Flavodoxin HEC78_RS23005 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HEC78_RS23020 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HEC78_RS23040 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HEC78_RS23045 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HEC78_RS23065 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HEC78_RS23070 ENOG4105F9E Shikimate 5-dehydrogenase HEC78_RS23075 ENOG4105DM4 PTS System HEC78_RS23080 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HEC78_RS23085 ENOG4105C8U phosphate abc transporter HEC78_RS23090 ENOG4105E2Z phosphate ABC transporter (Permease HEC78_RS23095 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HEC78_RS23105 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HEC78_RS23110 ENOG4105C7N Xanthine uracil vitamin C permease HEC78_RS23115 ENOG4108YYH Nadph-dependent fmn reductase HEC78_RS23120 ENOG4105E8Q phosphopantetheinyl transferase HEC78_RS23155 ENOG4105VG0 50S ribosomal protein l34 HEC78_RS23205 ENOG4105C4R Atp-dependent dna helicase HEC78_RS23380 ENOG4105DFE Dna adenine methylase HEC78_RS23420 ENOG4106JVB Replication Protein HEC78_RS23440 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEC78_RS23610 ENOG41074AV Hok/gef family HEC78_RS23615 ENOG4108BUD transposase HEC78_RS23655 ENOG4108BUD transposase HEC78_RS23680 ENOG4108KTG Membrane protein, drug metabolite transporter HEC78_RS23775 ENOG4108BUD transposase HEC78_RS23805 ENOG4105VUN Transcriptional regulator HEC78_RS23815 ENOG4108BUD transposase HEC78_RS23835 ENOG4108BUD transposase HEC78_RS23850 ENOG4108BUD transposase HEC78_RS23870 ENOG4108R0M Aminoglycoside HEC78_RS23885 ENOG4105KK6 nuclease HEC78_RS23895 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEC78_RS23900 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HEC78_RS23965 ENOG4105CAF HipA N-terminal domain protein HEC78_RS24045 ENOG4105DAX Pfam:DUF2983 HEC78_RS24075 ENOG4108M24 von Willebrand factor, type A HEC78_RS24080 ENOG4108M24 von Willebrand factor, type A