locus-tag	class	description
HEC78_RS00030	COG4948	Mandelate Racemase Muconate Lactonizing
HEC78_RS00035	COG2271	Major facilitator Superfamily
HEC78_RS00040	COG0561	phosphatase activity
HEC78_RS00045	COG2186	Transcriptional regulator
HEC78_RS00050	COG3734	2-keto-3-deoxy-galactonokinase
HEC78_RS00055	COG0800	Aldolase
HEC78_RS00065	COG2271	Major facilitator Superfamily
HEC78_RS00070	COG2198	Histidine kinase
HEC78_RS00070	COG0784	Response regulator, receiver
HEC78_RS00070	COG2205	protein histidine kinase activity
HEC78_RS00075	COG1879	ABC-type sugar transport system periplasmic component
HEC78_RS00080	COG0745	RESPONSE REGULATOR receiver
HEC78_RS00085	COG3005	denitrification pathway
HEC78_RS00100	COG1858	cytochrome C peroxidase
HEC78_RS00135	COG1138	Cytochrome C-type biogenesis protein
HEC78_RS00155	COG0823	Involved in the tonB-independent uptake of proteins
HEC78_RS00160	COG5645	(Lipo)protein
HEC78_RS00180	COG2149	membrane
HEC78_RS00190	COG0641	radical SAM
HEC78_RS00200	COG2610	gluconate transmembrane transporter activity
HEC78_RS00205	COG0583	DNA-binding transcription factor activity
HEC78_RS00215	COG2814	Major facilitator Superfamily
HEC78_RS00240	COG0028	Belongs to the TPP enzyme family
HEC78_RS00245	COG0440	acetolactate synthase activity
HEC78_RS00250	COG1349	DNA-binding transcription factor activity
HEC78_RS00260	COG0738	Major facilitator superfamily
HEC78_RS00295	COG2188	Transcriptional regulator
HEC78_RS00300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS00300	COG3711	transcriptional antiterminator
HEC78_RS00305	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC78_RS00310	COG3775	system Galactitol-specific IIC component
HEC78_RS00345	COG2723	6-phospho-beta-galactosidase activity
HEC78_RS00365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS00365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC78_RS00370	COG3715	PTS system
HEC78_RS00375	COG3716	PTS system mannose fructose sorbose family IID component
HEC78_RS00390	COG5464	transposase or invertase
HEC78_RS00420	COG1335	isochorismatase
HEC78_RS00430	COG3710	Transcriptional regulator
HEC78_RS00445	COG2771	luxR family
HEC78_RS00465	COG0419	ATPase involved in DNA repair
HEC78_RS00485	COG2211	Major facilitator Superfamily
HEC78_RS00490	COG1501	Belongs to the glycosyl hydrolase 31 family
HEC78_RS00495	COG2982	Protein involved in outer membrane biogenesis
HEC78_RS00500	COG2233	PERMEase
HEC78_RS00505	COG0786	glutamate:sodium symporter activity
HEC78_RS00510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEC78_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC78_RS00520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEC78_RS00540	COG2860	membrane
HEC78_RS00550	COG0583	DNA-binding transcription factor activity
HEC78_RS00555	COG1561	YicC-like family, N-terminal region
HEC78_RS00580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEC78_RS00610	COG1519	Transferase
HEC78_RS00615	COG0859	PFAM glycosyl transferase family 9
HEC78_RS00620	COG0438	transferase activity, transferring glycosyl groups
HEC78_RS00695	COG1216	Glycosyl transferase, family 2
HEC78_RS00700	COG2861	carbohydrate metabolic process
HEC78_RS00705	COG4942	peptidase
HEC78_RS00715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC78_RS00720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HEC78_RS00740	COG2271	Major facilitator Superfamily
HEC78_RS00750	COG1609	Transcriptional regulator
HEC78_RS00755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEC78_RS00765	COG2186	Transcriptional regulator
HEC78_RS00795	COG3722	fumarate hydratase activity
HEC78_RS00800	COG0246	Mannitol dehydrogenase
HEC78_RS00805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS00805	COG2213	PTS system mannitol-specific
HEC78_RS00810	COG0625	glutathione transferase activity
HEC78_RS00820	COG3276	selenocysteine insertion sequence binding
HEC78_RS00825	COG1940	carbohydrate kinase activity
HEC78_RS00830	COG1012	belongs to the aldehyde dehydrogenase family
HEC78_RS00845	COG0235	Class ii aldolase
HEC78_RS00850	COG3623	hexulose-6-phosphate isomerase
HEC78_RS00855	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HEC78_RS00860	COG1070	Carbohydrate kinase
HEC78_RS00865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEC78_RS00870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HEC78_RS00875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HEC78_RS00885	COG2731	YhcH YjgK YiaL family protein
HEC78_RS00895	COG1414	Transcriptional regulator
HEC78_RS00900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC78_RS00905	COG3977	Valine--pyruvate aminotransferase
HEC78_RS00910	COG0366	Alpha amylase catalytic
HEC78_RS00915	COG2992	FlgJ-related protein
HEC78_RS00920	COG1609	Transcriptional regulator
HEC78_RS00920	COG2207	Transcriptional regulator
HEC78_RS00925	COG2115	Belongs to the xylose isomerase family
HEC78_RS00930	COG1070	Carbohydrate kinase
HEC78_RS00935	COG4682	membrane
HEC78_RS00940	COG3274	enterobacterial common antigen metabolic process
HEC78_RS00970	COG1278	Cold shock
HEC78_RS00975	COG2944	sequence-specific DNA binding
HEC78_RS00990	COG2885	chlorophyll binding
HEC78_RS00995	COG0243	molybdopterin cofactor binding
HEC78_RS01000	COG0456	acetyltransferase
HEC78_RS01005	COG2818	Glycosylase
HEC78_RS01010	COG5571	outer membrane autotransporter
HEC78_RS01040	COG1609	Transcriptional regulator
HEC78_RS01055	COG0747	negative chemotaxis
HEC78_RS01060	COG0601	transmembrane transport
HEC78_RS01065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEC78_RS01070	COG0444	Belongs to the ABC transporter superfamily
HEC78_RS01075	COG4608	Belongs to the ABC transporter superfamily
HEC78_RS01080	COG0814	amino acid
HEC78_RS01125	COG1215	transferase activity, transferring glycosyl groups
HEC78_RS01140	COG2199	diguanylate cyclase activity
HEC78_RS01140	COG2200	EAL domain
HEC78_RS01155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS01160	COG2200	EAL domain
HEC78_RS01165	COG2982	Protein involved in outer membrane biogenesis
HEC78_RS01170	COG0477	Major facilitator Superfamily
HEC78_RS01175	COG1295	ribonuclease BN
HEC78_RS01180	COG0583	DNA-binding transcription factor activity
HEC78_RS01185	COG2197	response regulator
HEC78_RS01205	COG2188	Transcriptional regulator
HEC78_RS01210	COG2222	sugar isomerase
HEC78_RS01215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS01220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC78_RS01230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC78_RS01235	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEC78_RS01240	COG0671	phosphoesterase, PA-phosphatase related
HEC78_RS01270	COG0306	phosphate transporter
HEC78_RS01275	COG2081	HI0933 family
HEC78_RS01280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC78_RS01285	COG1129	ABC transporter
HEC78_RS01285	COG0842	Transport permease protein
HEC78_RS01290	COG0842	Transport permease protein
HEC78_RS01305	COG0628	permease
HEC78_RS01320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEC78_RS01340	COG3714	YhhN family
HEC78_RS01350	COG3776	membrane
HEC78_RS01355	COG0742	ribosomal rna small subunit methyltransferase
HEC78_RS01360	COG0552	protein localization to endoplasmic reticulum
HEC78_RS01365	COG2884	Cell division ATP-binding protein ftsE
HEC78_RS01370	COG2177	Part of the ABC transporter FtsEX involved in
HEC78_RS01445	COG0584	glycerophosphoryl diester phosphodiesterase
HEC78_RS01455	COG0405	Gamma-glutamyltransferase
HEC78_RS01460	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HEC78_RS01475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS01480	COG1247	-acetyltransferase
HEC78_RS01485	COG0673	inositol 2-dehydrogenase activity
HEC78_RS01490	COG1741	Belongs to the pirin family
HEC78_RS01495	COG1609	Transcriptional regulator
HEC78_RS01500	COG3265	gluconokinase activity
HEC78_RS01505	COG2610	gluconate transmembrane transporter activity
HEC78_RS01520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEC78_RS01540	COG0058	SHG alpha-glucan phosphorylase activity
HEC78_RS01545	COG1414	Transcriptional regulator
HEC78_RS01550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEC78_RS01555	COG0129	dihydroxy-acid dehydratase activity
HEC78_RS01565	COG0371	Dehydrogenase
HEC78_RS01580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEC78_RS01595	COG1349	DNA-binding transcription factor activity
HEC78_RS01605	COG0058	SHG alpha-glucan phosphorylase activity
HEC78_RS01610	COG1640	4-alpha-glucanotransferase
HEC78_RS01615	COG2610	gluconate transmembrane transporter activity
HEC78_RS01625	COG1040	competence protein
HEC78_RS01635	COG5464	transposase or invertase
HEC78_RS01650	COG1918	ferrous iron import across plasma membrane
HEC78_RS01655	COG2183	response to ionizing radiation
HEC78_RS01660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEC78_RS01665	COG0745	RESPONSE REGULATOR receiver
HEC78_RS01680	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HEC78_RS01690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HEC78_RS01695	COG1011	Hydrolase
HEC78_RS01705	COG0494	nUDIX hydrolase
HEC78_RS01710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEC78_RS01715	COG4972	Pilus assembly protein
HEC78_RS01720	COG3166	PFAM Fimbrial assembly family protein
HEC78_RS01735	COG4796	Type ii and iii secretion system protein
HEC78_RS01750	COG3266	domain, Protein
HEC78_RS01755	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HEC78_RS01760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEC78_RS01800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEC78_RS01810	COG0738	Major facilitator superfamily
HEC78_RS01840	COG1289	transmembrane transporter activity
HEC78_RS01850	COG1765	OsmC-like protein
HEC78_RS01855	COG3954	Phosphoribulokinase
HEC78_RS01865	COG0429	hydrolase of the alpha beta-hydrolase fold
HEC78_RS01880	COG0488	(ABC) transporter
HEC78_RS01895	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HEC78_RS01900	COG1047	Peptidyl-prolyl cis-trans
HEC78_RS01910	COG0545	Peptidyl-prolyl cis-trans isomerase
HEC78_RS01915	COG2964	Protein conserved in bacteria
HEC78_RS01970	COG0051	transcription antitermination factor activity, RNA binding
HEC78_RS01995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEC78_RS02075	COG0201	protein transport
HEC78_RS02115	COG0789	Transcriptional regulator
HEC78_RS02120	COG3036	rescue of stalled ribosome
HEC78_RS02150	COG0758	DNA mediated transformation
HEC78_RS02160	COG0551	DNA topoisomerase type I activity
HEC78_RS02180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC78_RS02225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC78_RS02230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC78_RS02235	COG1309	transcriptional regulator
HEC78_RS02250	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HEC78_RS02275	COG4145	pantothenate transmembrane transporter activity
HEC78_RS02280	COG3924	membrane
HEC78_RS02285	COG0439	Biotin carboxylase
HEC78_RS02290	COG0511	ligase activity, forming carbon-carbon bonds
HEC78_RS02305	COG0604	alcohol dehydrogenase
HEC78_RS02310	COG2200	EAL domain
HEC78_RS02310	COG2199	diguanylate cyclase activity
HEC78_RS02315	COG1077	Cell shape determining protein MreB Mrl
HEC78_RS02320	COG1792	Involved in formation and maintenance of cell shape
HEC78_RS02325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HEC78_RS02335	COG1530	ribonuclease E activity
HEC78_RS02340	COG3164	Protein of unknown function
HEC78_RS02345	COG0312	modulator of DNA gyrase
HEC78_RS02350	COG0583	DNA-binding transcription factor activity
HEC78_RS02375	COG2732	(Barnase) inhibitor
HEC78_RS02400	COG2188	Transcriptional regulator
HEC78_RS02410	COG0471	metal ion transport
HEC78_RS02415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC78_RS02420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC78_RS02425	COG3630	sodium ion export across plasma membrane
HEC78_RS02430	COG5016	pyruvate
HEC78_RS02430	COG0511	ligase activity, forming carbon-carbon bonds
HEC78_RS02435	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HEC78_RS02450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEC78_RS02455	COG3105	Protein conserved in bacteria
HEC78_RS02460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEC78_RS02480	COG0625	glutathione transferase activity
HEC78_RS02485	COG2969	positive regulation of protein catabolic process
HEC78_RS02515	COG2731	YhcH YjgK YiaL family protein
HEC78_RS02520	COG0402	S-adenosylhomocysteine deaminase activity
HEC78_RS02525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEC78_RS02530	COG4804	nuclease activity
HEC78_RS02535	COG0493	'glutamate synthase
HEC78_RS02540	COG0070	glutamate synthase
HEC78_RS02540	COG0069	glutamate synthase activity
HEC78_RS02540	COG0067	glutamate synthase
HEC78_RS02545	COG1242	4 iron, 4 sulfur cluster binding
HEC78_RS02550	COG0784	Response regulator, receiver
HEC78_RS02550	COG2198	Histidine kinase
HEC78_RS02550	COG5002	protein histidine kinase activity
HEC78_RS02555	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HEC78_RS02565	COG0515	serine threonine protein kinase
HEC78_RS02570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS02595	COG1137	ATPase activity
HEC78_RS02600	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HEC78_RS02605	COG3117	lipopolysaccharide transmembrane transporter activity
HEC78_RS02610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEC78_RS02620	COG0530	calcium, potassium:sodium antiporter activity
HEC78_RS02625	COG1127	ABC transporter
HEC78_RS02630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEC78_RS02635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEC78_RS02640	COG2854	intermembrane phospholipid transfer
HEC78_RS02645	COG3113	response to antibiotic
HEC78_RS02650	COG5007	Belongs to the BolA IbaG family
HEC78_RS02660	COG3423	Transcriptional regulator
HEC78_RS02665	COG0142	geranyltranstransferase activity
HEC78_RS02680	COG0697	spore germination
HEC78_RS02690	COG2027	D-alanyl-D-alanine carboxypeptidase
HEC78_RS02700	COG1534	Rna-binding protein
HEC78_RS02715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEC78_RS02725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEC78_RS02795	COG0513	Belongs to the DEAD box helicase family
HEC78_RS02800	COG0814	amino acid
HEC78_RS02810	COG3034	peptidoglycan biosynthetic process
HEC78_RS02815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEC78_RS02820	COG0826	peptidase U32
HEC78_RS02825	COG0826	peptidase U32
HEC78_RS02830	COG3154	lipid carrier protein
HEC78_RS02835	COG3153	acetyltransferase
HEC78_RS02850	COG0693	protein deglycase activity
HEC78_RS02855	COG0702	epimerase
HEC78_RS02860	COG2823	Periplasmic or secreted lipoprotein
HEC78_RS02875	COG3107	peptidoglycan biosynthetic process
HEC78_RS02880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HEC78_RS02890	COG1063	alcohol dehydrogenase
HEC78_RS02895	COG3775	system Galactitol-specific IIC component
HEC78_RS02900	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC78_RS02905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS02920	COG2721	sulfolactate sulfo-lyase activity
HEC78_RS02930	COG2084	Dehydrogenase
HEC78_RS02935	COG1929	Belongs to the glycerate kinase type-1 family
HEC78_RS02945	COG0583	DNA-binding transcription factor activity
HEC78_RS02960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEC78_RS02965	COG1882	Formate acetyltransferase
HEC78_RS02970	COG1760	l-serine dehydratase
HEC78_RS02975	COG0814	amino acid
HEC78_RS02990	COG1741	Belongs to the pirin family
HEC78_RS02995	COG0583	DNA-binding transcription factor activity
HEC78_RS03000	COG3152	Membrane
HEC78_RS03005	COG0435	Glutathione S-transferase
HEC78_RS03010	COG2259	Doxx family
HEC78_RS03020	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HEC78_RS03025	COG4575	ribosome binding
HEC78_RS03030	COG1422	Protein of unknown function (DUF1090)
HEC78_RS03040	COG0586	Pfam SNARE associated Golgi protein
HEC78_RS03055	COG0673	inositol 2-dehydrogenase activity
HEC78_RS03060	COG2949	membrane
HEC78_RS03065	COG1451	nucleotide metabolic process
HEC78_RS03075	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEC78_RS03075	COG1902	pentaerythritol trinitrate reductase activity
HEC78_RS03085	COG0840	transmembrane signaling receptor activity
HEC78_RS03095	COG0840	transmembrane signaling receptor activity
HEC78_RS03100	COG1695	Transcriptional regulator
HEC78_RS03105	COG2375	cellular response to nickel ion
HEC78_RS03110	COG4974	Belongs to the 'phage' integrase family
HEC78_RS03155	COG2176	DNA-directed DNA polymerase activity
HEC78_RS03155	COG5002	protein histidine kinase activity
HEC78_RS03185	COG4695	Portal protein
HEC78_RS03280	COG5301	cellulose 1,4-beta-cellobiosidase activity
HEC78_RS03330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HEC78_RS03355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEC78_RS03370	COG4991	sh3 domain protein
HEC78_RS03375	COG3025	triphosphatase activity
HEC78_RS03395	COG2268	Band 7 protein
HEC78_RS03400	COG1585	Membrane protein implicated in regulation of membrane protease activity
HEC78_RS03440	COG3384	dioxygenase
HEC78_RS03445	COG0754	glutathionylspermidine amidase activity
HEC78_RS03460	COG0494	nUDIX hydrolase
HEC78_RS03465	COG3151	Protein conserved in bacteria
HEC78_RS03470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEC78_RS03475	COG3150	esterase
HEC78_RS03485	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HEC78_RS03490	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEC78_RS03505	COG3111	PFAM Bacterial OB fold (BOF) protein
HEC78_RS03510	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HEC78_RS03560	COG0471	metal ion transport
HEC78_RS03570	COG1979	alcohol dehydrogenase
HEC78_RS03575	COG2207	Transcriptional regulator
HEC78_RS03595	COG0848	biopolymer transport protein
HEC78_RS03600	COG1028	Short-chain dehydrogenase reductase Sdr
HEC78_RS03625	COG0840	transmembrane signaling receptor activity
HEC78_RS03635	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HEC78_RS03640	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS03645	COG5557	Pfam Polysulphide reductase, NrfD
HEC78_RS03650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEC78_RS03655	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC78_RS03660	COG1773	rubredoxin
HEC78_RS03670	COG0298	carbon dioxide binding
HEC78_RS03685	COG0625	glutathione transferase activity
HEC78_RS03690	COG0754	glutathionylspermidine amidase activity
HEC78_RS03705	COG0246	Mannitol dehydrogenase
HEC78_RS03715	COG2271	Major facilitator Superfamily
HEC78_RS03740	COG1012	belongs to the aldehyde dehydrogenase family
HEC78_RS03745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEC78_RS03755	COG0531	amino acid
HEC78_RS03770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC78_RS03795	COG1811	Na channel or pump
HEC78_RS03800	COG1982	Orn Lys Arg decarboxylase major
HEC78_RS03805	COG2211	Major facilitator Superfamily
HEC78_RS03830	COG3171	Protein conserved in bacteria
HEC78_RS03840	COG0252	asparaginase activity
HEC78_RS03850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEC78_RS03855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEC78_RS03865	COG0762	integral membrane protein
HEC78_RS03870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HEC78_RS03875	COG2805	Type II/IV secretion system protein
HEC78_RS03900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEC78_RS03905	COG2356	endonuclease I
HEC78_RS03940	COG1166	arginine decarboxylase activity
HEC78_RS03950	COG0501	Belongs to the peptidase M48B family
HEC78_RS03955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEC78_RS03960	COG1122	ATPase activity
HEC78_RS03965	COG1122	ATPase activity
HEC78_RS03995	COG0191	fructose-bisphosphate aldolase activity
HEC78_RS04000	COG0668	transmembrane transport
HEC78_RS04010	COG2968	Membrane
HEC78_RS04030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEC78_RS04035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEC78_RS04055	COG0006	proline dipeptidase activity
HEC78_RS04060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC78_RS04065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC78_RS04090	COG2723	6-phospho-beta-galactosidase activity
HEC78_RS04100	COG1272	protein, Hemolysin III
HEC78_RS04160	COG4942	peptidase
HEC78_RS04205	COG3188	usher protein
HEC78_RS04240	COG0814	amino acid
HEC78_RS04255	COG0183	Belongs to the thiolase family
HEC78_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
HEC78_RS04270	COG2814	Major facilitator Superfamily
HEC78_RS04275	COG1794	racemase activity, acting on amino acids and derivatives
HEC78_RS04280	COG0583	DNA-binding transcription factor activity
HEC78_RS04290	COG1609	Transcriptional regulator
HEC78_RS04310	COG0667	Aldo Keto reductase
HEC78_RS04320	COG0861	Integral membrane protein TerC family
HEC78_RS04350	COG2165	general secretion pathway protein
HEC78_RS04355	COG4795	General secretion pathway protein
HEC78_RS04365	COG4967	type IV pilus modification protein PilV
HEC78_RS04370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEC78_RS04375	COG1025	Belongs to the peptidase M16 family
HEC78_RS04380	COG1074	ATP-dependent DNA helicase activity
HEC78_RS04385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEC78_RS04390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEC78_RS04390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HEC78_RS04395	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEC78_RS04410	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HEC78_RS04415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEC78_RS04420	COG2962	Rard protein
HEC78_RS04425	COG2166	iron-sulfur cluster assembly
HEC78_RS04430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEC78_RS04440	COG0583	DNA-binding transcription factor activity
HEC78_RS04445	COG2363	Small membrane protein
HEC78_RS04455	COG1349	DNA-binding transcription factor activity
HEC78_RS04475	COG0738	Major facilitator superfamily
HEC78_RS04480	COG0235	Class ii aldolase
HEC78_RS04485	COG1454	alcohol dehydrogenase
HEC78_RS04495	COG1760	l-serine dehydratase
HEC78_RS04500	COG0814	amino acid
HEC78_RS04505	COG1611	Belongs to the LOG family
HEC78_RS04535	COG0716	FMN binding
HEC78_RS04545	COG2271	Major facilitator Superfamily
HEC78_RS04550	COG4948	Mandelate Racemase Muconate Lactonizing
HEC78_RS04555	COG4948	Mandelate Racemase Muconate Lactonizing
HEC78_RS04560	COG1929	Belongs to the glycerate kinase type-1 family
HEC78_RS04565	COG4999	Histidine kinase
HEC78_RS04565	COG2205	protein histidine kinase activity
HEC78_RS04565	COG3437	response regulator, receiver
HEC78_RS04565	COG3850	Histidine kinase
HEC78_RS04575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEC78_RS04580	COG3609	addiction module antidote protein, CC2985 family
HEC78_RS04610	COG3539	Fimbrial protein
HEC78_RS04615	COG3121	Chaperone
HEC78_RS04620	COG3188	usher protein
HEC78_RS04625	COG3539	Fimbrial protein
HEC78_RS04630	COG3956	TIGRFAM MazG family protein
HEC78_RS04645	COG0602	queuosine metabolic process
HEC78_RS04650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HEC78_RS04650	COG0321	lipoyl(octanoyl) transferase activity
HEC78_RS04655	COG0720	synthase
HEC78_RS04680	COG1203	CRISPR-associated helicase, Cas3
HEC78_RS04695	COG1857	crispr-associated protein
HEC78_RS04710	COG1518	maintenance of DNA repeat elements
HEC78_RS04715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC78_RS04720	COG2234	aminopeptidase activity
HEC78_RS04790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEC78_RS04795	COG0163	prenyltransferase activity
HEC78_RS04805	COG1349	DNA-binding transcription factor activity
HEC78_RS04810	COG2084	Dehydrogenase
HEC78_RS04820	COG0235	Class ii aldolase
HEC78_RS04825	COG3622	Belongs to the hyi family
HEC78_RS04830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC78_RS04835	COG2610	gluconate transmembrane transporter activity
HEC78_RS04845	COG0477	Major facilitator Superfamily
HEC78_RS04925	COG2207	Transcriptional regulator
HEC78_RS05015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEC78_RS05095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC78_RS05100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC78_RS05105	COG1121	(ABC) transporter
HEC78_RS05125	COG0309	Hydrogenase expression formation protein (HypE)
HEC78_RS05130	COG0409	Hydrogenase expression formation protein
HEC78_RS05135	COG0298	carbon dioxide binding
HEC78_RS05140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEC78_RS05155	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC78_RS05160	COG0651	ATP synthesis coupled electron transport
HEC78_RS05165	COG0650	Formate hydrogenlyase subunit 4
HEC78_RS05170	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HEC78_RS05170	COG3261	NADH dehydrogenase
HEC78_RS05175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC78_RS05180	COG3260	NADH ubiquinone oxidoreductase 20
HEC78_RS05190	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC78_RS05200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC78_RS05205	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEC78_RS05230	COG1349	DNA-binding transcription factor activity
HEC78_RS05235	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
HEC78_RS05250	COG3732	PTS system glucitol sorbitol-specific
HEC78_RS05255	COG3730	PTS system glucitol sorbitol-specific
HEC78_RS05260	COG2951	lytic endotransglycosylase activity
HEC78_RS05265	COG1546	Belongs to the CinA family
HEC78_RS05285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEC78_RS05315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC78_RS05320	COG1238	metal cluster binding
HEC78_RS05340	COG2814	Major facilitator Superfamily
HEC78_RS05345	COG1566	PFAM secretion protein HlyD family protein
HEC78_RS05350	COG1846	Transcriptional regulator
HEC78_RS05355	COG2814	Major facilitator Superfamily
HEC78_RS05395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC78_RS05405	COG4575	ribosome binding
HEC78_RS05430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC78_RS05435	COG0640	Transcriptional regulator
HEC78_RS05440	COG0401	homolog of Blt101
HEC78_RS05445	COG1652	LysM domain
HEC78_RS05450	COG1802	Transcriptional regulator
HEC78_RS05455	COG1113	amino acid transport
HEC78_RS05460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEC78_RS05465	COG1012	belongs to the aldehyde dehydrogenase family
HEC78_RS05470	COG0579	oxidoreductase
HEC78_RS05500	COG0642	Histidine kinase
HEC78_RS05505	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC78_RS05515	COG2990	Protein conserved in bacteria
HEC78_RS05535	COG2819	hydrolase of the alpha beta superfamily
HEC78_RS05600	COG0582	viral genome integration into host DNA
HEC78_RS05610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC78_RS05635	COG2867	negative regulation of translational initiation
HEC78_RS05650	COG0497	DNA recombination
HEC78_RS05670	COG4536	flavin adenine dinucleotide binding
HEC78_RS05675	COG4137	Cytochrome C assembly protein
HEC78_RS05680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEC78_RS05705	COG2199	diguanylate cyclase activity
HEC78_RS05720	COG1605	Chorismate mutase
HEC78_RS05720	COG0287	Prephenate dehydrogenase
HEC78_RS05730	COG0077	Prephenate dehydratase
HEC78_RS05730	COG1605	Chorismate mutase
HEC78_RS05740	COG4974	Belongs to the 'phage' integrase family
HEC78_RS05780	COG4695	Portal protein
HEC78_RS05870	COG5301	cellulose 1,4-beta-cellobiosidase activity
HEC78_RS05900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEC78_RS05905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC78_RS05920	COG0542	response to heat
HEC78_RS05950	COG0477	Major facilitator Superfamily
HEC78_RS05955	COG5544	Lipoprotein
HEC78_RS05960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC78_RS05975	COG3118	belongs to the thioredoxin family
HEC78_RS05980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC78_RS06000	COG0583	DNA-binding transcription factor activity
HEC78_RS06005	COG0513	Belongs to the DEAD box helicase family
HEC78_RS06040	COG3086	response to oxidative stress
HEC78_RS06080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC78_RS06085	COG0583	DNA-binding transcription factor activity
HEC78_RS06090	COG2223	nitrite transmembrane transporter activity
HEC78_RS06095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEC78_RS06100	COG1737	Transcriptional regulator
HEC78_RS06110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC78_RS06110	COG1263	PTS System
HEC78_RS06115	COG0560	Phosphoserine phosphatase
HEC78_RS06140	COG2205	protein histidine kinase activity
HEC78_RS06145	COG3170	Tfp pilus assembly protein FimV
HEC78_RS06150	COG2204	response regulator
HEC78_RS06155	COG0347	Belongs to the P(II) protein family
HEC78_RS06160	COG3104	oligopeptide transport
HEC78_RS06170	COG0531	amino acid
HEC78_RS06175	COG3710	Transcriptional regulator
HEC78_RS06185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC78_RS06185	COG1017	nitric oxide dioxygenase activity
HEC78_RS06195	COG2814	Major facilitator Superfamily
HEC78_RS06200	COG3711	transcriptional antiterminator
HEC78_RS06210	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC78_RS06255	COG0822	iron-sulfur transferase activity
HEC78_RS06275	COG0633	Ferredoxin
HEC78_RS06280	COG2975	iron-sulfur cluster assembly
HEC78_RS06300	COG2897	thiosulfate sulfurtransferase activity
HEC78_RS06305	COG2373	Large extracellular alpha-helical protein
HEC78_RS06310	COG4953	penicillin-binding protein 1C
HEC78_RS06315	COG0243	molybdopterin cofactor binding
HEC78_RS06320	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS06360	COG2976	Protein conserved in bacteria
HEC78_RS06375	COG1645	bacterial-type flagellum-dependent swarming motility
HEC78_RS06415	COG0517	IMP dehydrogenase activity
HEC78_RS06415	COG0516	GMP reductase activity
HEC78_RS06440	COG3133	Outer membrane lipoprotein
HEC78_RS06455	COG2200	EAL domain
HEC78_RS06470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEC78_RS06485	COG2233	PERMEase
HEC78_RS06495	COG1393	Belongs to the ArsC family
HEC78_RS06505	COG0628	permease
HEC78_RS06510	COG3835	regulator
HEC78_RS06515	COG2610	gluconate transmembrane transporter activity
HEC78_RS06520	COG1929	Belongs to the glycerate kinase type-1 family
HEC78_RS06525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEC78_RS06530	COG2716	regulation of RNA biosynthetic process
HEC78_RS06535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEC78_RS06540	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HEC78_RS06550	COG2321	neutral zinc metallopeptidase
HEC78_RS06570	COG1393	Belongs to the ArsC family
HEC78_RS06580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC78_RS06585	COG3850	Histidine kinase
HEC78_RS06590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC78_RS06590	COG0493	'glutamate synthase
HEC78_RS06605	COG5342	invasion associated locus B
HEC78_RS06615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEC78_RS06740	COG2837	iron assimilation
HEC78_RS06760	COG4208	sulfate ABC transporter
HEC78_RS06765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEC78_RS06810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS06835	COG3530	Putative quorum-sensing-regulated virulence factor
HEC78_RS06840	COG0385	Bile acid
HEC78_RS06845	COG0583	DNA-binding transcription factor activity
HEC78_RS06855	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEC78_RS06860	COG2211	Major facilitator Superfamily
HEC78_RS06870	COG0583	DNA-binding transcription factor activity
HEC78_RS06900	COG3415	Transposase
HEC78_RS06905	COG3415	Transposase
HEC78_RS06920	COG2199	diguanylate cyclase activity
HEC78_RS06920	COG2200	EAL domain
HEC78_RS06925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEC78_RS06940	COG0667	Aldo Keto reductase
HEC78_RS06945	COG3961	Belongs to the TPP enzyme family
HEC78_RS06965	COG0436	Aminotransferase
HEC78_RS06975	COG1560	Kdo2-lipid A biosynthetic process
HEC78_RS07030	COG0463	Glycosyl transferase, family 2
HEC78_RS07035	COG2246	polysaccharide biosynthetic process
HEC78_RS07055	COG2116	formate transmembrane transporter activity
HEC78_RS07070	COG3691	Protein conserved in bacteria
HEC78_RS07085	COG2062	phosphohistidine phosphatase, SixA
HEC78_RS07110	COG0730	response to heat
HEC78_RS07115	COG3101	peptidyl-lysine hydroxylation
HEC78_RS07130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC78_RS07170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEC78_RS07180	COG0586	Pfam SNARE associated Golgi protein
HEC78_RS07190	COG0285	dihydrofolate synthase activity
HEC78_RS07195	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HEC78_RS07200	COG1286	toxin biosynthetic process
HEC78_RS07205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HEC78_RS07210	COG3829	transcription factor binding
HEC78_RS07220	COG0531	amino acid
HEC78_RS07225	COG3457	Alanine racemase
HEC78_RS07230	COG0833	amino acid
HEC78_RS07265	COG1090	epimerase
HEC78_RS07270	COG0625	glutathione transferase activity
HEC78_RS07275	COG0625	glutathione transferase activity
HEC78_RS07280	COG0622	Phosphoesterase
HEC78_RS07290	COG1609	Transcriptional regulator
HEC78_RS07295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS07305	COG3037	sugar-specific permease SgaT UlaA
HEC78_RS07310	COG3959	Transketolase, thiamine diphosphate binding domain
HEC78_RS07315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEC78_RS07320	COG1288	antiporter activity
HEC78_RS07345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC78_RS07350	COG0471	metal ion transport
HEC78_RS07350	COG0490	domain, Protein
HEC78_RS07360	COG0436	Aminotransferase
HEC78_RS07365	COG0583	DNA-binding transcription factor activity
HEC78_RS07415	COG0839	Belongs to the complex I subunit 6 family
HEC78_RS07425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEC78_RS07430	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC78_RS07440	COG0835	chemotaxis
HEC78_RS07440	COG0784	Response regulator, receiver
HEC78_RS07450	COG2153	protein acetylation
HEC78_RS07455	COG4575	ribosome binding
HEC78_RS07460	COG1169	isochorismate synthase
HEC78_RS07555	COG0247	lactate metabolic process
HEC78_RS07565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEC78_RS07570	COG2271	Major facilitator Superfamily
HEC78_RS07575	COG0584	glycerophosphoryl diester phosphodiesterase
HEC78_RS07580	COG0583	DNA-binding transcription factor activity
HEC78_RS07585	COG2814	Major facilitator Superfamily
HEC78_RS07590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC78_RS07620	COG4948	Mandelate Racemase Muconate Lactonizing
HEC78_RS07640	COG2198	Histidine kinase
HEC78_RS07640	COG0642	Histidine kinase
HEC78_RS07665	COG4615	Cyclic peptide transporter
HEC78_RS07675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC78_RS07675	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC78_RS07680	COG3062	negative regulation of establishment of protein localization
HEC78_RS07690	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS07695	COG0348	domain, Protein
HEC78_RS07700	COG3043	anaerobic respiration
HEC78_RS07705	COG3005	denitrification pathway
HEC78_RS07715	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC78_RS07720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC78_RS07725	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEC78_RS07735	COG1138	Cytochrome C-type biogenesis protein
HEC78_RS07745	COG3088	subunit of a heme lyase
HEC78_RS07745	COG4235	cytochrome complex assembly
HEC78_RS07750	COG2197	response regulator
HEC78_RS07815	COG1061	Type III restriction enzyme res subunit
HEC78_RS07825	COG2814	Major facilitator Superfamily
HEC78_RS07835	COG4172	Belongs to the ABC transporter superfamily
HEC78_RS07840	COG4239	(ABC) transporter, permease
HEC78_RS07845	COG4174	ABC transporter (Permease)
HEC78_RS07850	COG4166	transmembrane transport
HEC78_RS07855	COG2200	EAL domain
HEC78_RS07860	COG0791	NLP P60 protein
HEC78_RS07865	COG0671	phosphoesterase, PA-phosphatase related
HEC78_RS07870	COG0523	cobalamin synthesis protein
HEC78_RS07905	COG1105	Belongs to the carbohydrate kinase PfkB family
HEC78_RS07910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC78_RS07910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC78_RS07910	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HEC78_RS07915	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HEC78_RS07920	COG2855	membrane
HEC78_RS07925	COG0583	DNA-binding transcription factor activity
HEC78_RS07930	COG0833	amino acid
HEC78_RS07935	COG4771	TonB-dependent receptor
HEC78_RS07940	COG2271	Major facilitator Superfamily
HEC78_RS07945	COG0560	Phosphoserine phosphatase
HEC78_RS07950	COG1760	l-serine dehydratase
HEC78_RS07970	COG2311	Membrane
HEC78_RS08010	COG2949	membrane
HEC78_RS08020	COG1346	cytolysis
HEC78_RS08035	COG2271	Major facilitator Superfamily
HEC78_RS08050	COG0625	glutathione transferase activity
HEC78_RS08055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC78_RS08070	COG1538	Outer membrane efflux protein
HEC78_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
HEC78_RS08080	COG0586	Pfam SNARE associated Golgi protein
HEC78_RS08090	COG1686	Belongs to the peptidase S11 family
HEC78_RS08095	COG0277	FAD linked oxidase domain protein
HEC78_RS08105	COG1732	Glycine betaine
HEC78_RS08110	COG1174	glycine betaine transport
HEC78_RS08115	COG1125	glycine betaine transport
HEC78_RS08120	COG1174	glycine betaine transport
HEC78_RS08135	COG3275	phosphorelay sensor kinase activity
HEC78_RS08145	COG4807	Protein conserved in bacteria
HEC78_RS08155	COG4808	Protein conserved in bacteria
HEC78_RS08180	COG3121	Chaperone
HEC78_RS08185	COG3188	usher protein
HEC78_RS08195	COG5455	response to cobalt ion
HEC78_RS08210	COG2188	Transcriptional regulator
HEC78_RS08215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS08220	COG1397	ADP-ribosylglycohydrolase
HEC78_RS08225	COG2211	Major facilitator Superfamily
HEC78_RS08230	COG1830	Aldolase
HEC78_RS08280	COG3209	COG3209 Rhs family protein
HEC78_RS08295	COG3209	COG3209 Rhs family protein
HEC78_RS08300	COG3209	COG3209 Rhs family protein
HEC78_RS08310	COG1413	lyase activity
HEC78_RS08315	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HEC78_RS08360	COG0745	RESPONSE REGULATOR receiver
HEC78_RS08365	COG2205	protein histidine kinase activity
HEC78_RS08395	COG0443	Heat shock 70 kDa protein
HEC78_RS08400	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEC78_RS08405	COG3447	MASE1 domain protein
HEC78_RS08405	COG5001	Diguanylate cyclase
HEC78_RS08405	COG5002	protein histidine kinase activity
HEC78_RS08420	COG2982	Protein involved in outer membrane biogenesis
HEC78_RS08425	COG1253	flavin adenine dinucleotide binding
HEC78_RS08445	COG0463	Glycosyl transferase, family 2
HEC78_RS08450	COG1045	serine acetyltransferase
HEC78_RS08455	COG0438	transferase activity, transferring glycosyl groups
HEC78_RS08465	COG1216	Glycosyl transferase, family 2
HEC78_RS08470	COG0110	maltose O-acetyltransferase activity
HEC78_RS08475	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEC78_RS08480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC78_RS08490	COG0297	glycogen (starch) synthase activity
HEC78_RS08505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEC78_RS08510	COG2244	polysaccharide biosynthetic process
HEC78_RS08515	COG2327	Polysaccharide pyruvyl transferase
HEC78_RS08560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEC78_RS08675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC78_RS08680	COG0583	DNA-binding transcription factor activity
HEC78_RS08690	COG0531	amino acid
HEC78_RS08695	COG2925	Exonuclease
HEC78_RS08735	COG1289	transmembrane transporter activity
HEC78_RS08770	COG4656	Part of a membrane complex involved in electron transport
HEC78_RS08775	COG1012	belongs to the aldehyde dehydrogenase family
HEC78_RS08775	COG1454	alcohol dehydrogenase
HEC78_RS08805	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEC78_RS08865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HEC78_RS08935	COG1122	ATPase activity
HEC78_RS08970	COG0534	Mate efflux family protein
HEC78_RS08980	COG0582	viral genome integration into host DNA
HEC78_RS08990	COG3423	Transcriptional regulator
HEC78_RS09025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEC78_RS09030	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEC78_RS09035	COG1733	regulation of RNA biosynthetic process
HEC78_RS09195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEC78_RS09205	COG0582	viral genome integration into host DNA
HEC78_RS09235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC78_RS09245	COG1418	mRNA catabolic process
HEC78_RS09250	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEC78_RS09255	COG3727	T/G mismatch-specific endonuclease activity
HEC78_RS09260	COG0697	spore germination
HEC78_RS09265	COG2354	Protein conserved in bacteria
HEC78_RS09270	COG5475	Uncharacterized small protein (DUF2158)
HEC78_RS09375	COG0425	Belongs to the sulfur carrier protein TusA family
HEC78_RS09450	COG2197	response regulator
HEC78_RS09465	COG2197	response regulator
HEC78_RS09510	COG3318	Belongs to the UPF0149 family
HEC78_RS09510	COG3012	SEC-C Motif Domain Protein
HEC78_RS09515	COG0814	amino acid
HEC78_RS09525	COG1528	Iron-storage protein
HEC78_RS09540	COG1528	Iron-storage protein
HEC78_RS09645	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HEC78_RS09660	COG3102	Protein conserved in bacteria
HEC78_RS09680	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HEC78_RS09685	COG1801	Protein of unknown function DUF72
HEC78_RS09690	COG1335	isochorismatase
HEC78_RS09700	COG0494	nUDIX hydrolase
HEC78_RS09735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC78_RS09740	COG1121	(ABC) transporter
HEC78_RS09745	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HEC78_RS09750	COG0739	heme binding
HEC78_RS09755	COG1560	Kdo2-lipid A biosynthetic process
HEC78_RS09765	COG1737	Transcriptional regulator
HEC78_RS09770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEC78_RS09775	COG0129	dihydroxy-acid dehydratase activity
HEC78_RS09780	COG0800	Aldolase
HEC78_RS09790	COG3141	response to X-ray
HEC78_RS09800	COG2979	Protein of unknown function (DUF533)
HEC78_RS09805	COG1770	oligopeptidase
HEC78_RS09810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC78_RS09815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC78_RS09825	COG2372	response to copper ion
HEC78_RS09830	COG1276	copper resistance
HEC78_RS09840	COG0582	viral genome integration into host DNA
HEC78_RS09905	COG5562	phage envelope protein
HEC78_RS09940	COG3008	intermembrane lipid transfer
HEC78_RS09945	COG2995	paraquat-inducible protein a
HEC78_RS09950	COG1956	GAF domain-containing protein
HEC78_RS09970	COG2814	Major facilitator Superfamily
HEC78_RS09975	COG1414	Transcriptional regulator
HEC78_RS10005	COG0768	penicillin binding
HEC78_RS10010	COG2226	methyltransferase
HEC78_RS10025	COG3716	PTS system mannose fructose sorbose family IID component
HEC78_RS10030	COG3715	PTS system
HEC78_RS10035	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS10035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC78_RS10040	COG1253	flavin adenine dinucleotide binding
HEC78_RS10045	COG2200	EAL domain
HEC78_RS10050	COG1760	l-serine dehydratase
HEC78_RS10070	COG0251	oxidation-reduction process
HEC78_RS10075	COG1199	ATP-dependent helicase activity
HEC78_RS10085	COG3065	identical protein binding
HEC78_RS10095	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEC78_RS10105	COG2894	cell division
HEC78_RS10120	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEC78_RS10160	COG2719	SpoVR family
HEC78_RS10180	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEC78_RS10205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEC78_RS10215	COG1294	oxidase, subunit
HEC78_RS10220	COG1271	oxidase subunit
HEC78_RS10225	COG1773	rubredoxin
HEC78_RS10230	COG1999	signal sequence binding
HEC78_RS10235	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC78_RS10240	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HEC78_RS10310	COG3423	Transcriptional regulator
HEC78_RS10325	COG2003	Belongs to the UPF0758 family
HEC78_RS10345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HEC78_RS10370	COG5290	Psort location Cytoplasmic, score
HEC78_RS10410	COG2963	transposase activity
HEC78_RS10415	COG2826	transposase and inactivated derivatives, IS30 family
HEC78_RS10425	COG0582	viral genome integration into host DNA
HEC78_RS10430	COG0012	GTP binding
HEC78_RS10445	COG0659	secondary active sulfate transmembrane transporter activity
HEC78_RS10495	COG0387	Pfam Sodium calcium exchanger
HEC78_RS10500	COG4572	Cation transport regulator
HEC78_RS10505	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HEC78_RS10510	COG4932	domain protein
HEC78_RS10515	COG2197	response regulator
HEC78_RS10520	COG3850	Histidine kinase
HEC78_RS10525	COG2223	nitrite transmembrane transporter activity
HEC78_RS10530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HEC78_RS10535	COG1140	nitrate reductase beta subunit
HEC78_RS10540	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HEC78_RS10545	COG2181	nitrate reductase activity
HEC78_RS10575	COG0788	formyltetrahydrofolate deformylase activity
HEC78_RS10585	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEC78_RS10590	COG0745	RESPONSE REGULATOR receiver
HEC78_RS10595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEC78_RS10610	COG1454	alcohol dehydrogenase
HEC78_RS10610	COG1012	belongs to the aldehyde dehydrogenase family
HEC78_RS10615	COG2095	MarC family integral membrane protein
HEC78_RS10645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEC78_RS10665	COG2350	Protein conserved in bacteria
HEC78_RS10690	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEC78_RS10700	COG3546	catalase activity
HEC78_RS10705	COG3685	Protein conserved in bacteria
HEC78_RS10710	COG3685	Protein conserved in bacteria
HEC78_RS10715	COG3729	General stress protein
HEC78_RS10755	COG0009	L-threonylcarbamoyladenylate synthase
HEC78_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
HEC78_RS10775	COG0616	signal peptide processing
HEC78_RS10815	COG0671	phosphoesterase, PA-phosphatase related
HEC78_RS10820	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HEC78_RS10825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEC78_RS10845	COG1349	DNA-binding transcription factor activity
HEC78_RS10855	COG5001	Diguanylate cyclase
HEC78_RS10865	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC78_RS10865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC78_RS10955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HEC78_RS10960	COG1842	Phage shock protein A
HEC78_RS10970	COG1983	PspC domain protein
HEC78_RS10980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC78_RS10985	COG3106	COG3106 Predicted ATPase
HEC78_RS11005	COG4948	Mandelate Racemase Muconate Lactonizing
HEC78_RS11010	COG2866	Carboxypeptidase
HEC78_RS11015	COG4166	transmembrane transport
HEC78_RS11025	COG0583	DNA-binding transcription factor activity
HEC78_RS11030	COG0656	L-ascorbic acid biosynthetic process
HEC78_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
HEC78_RS11040	COG1309	transcriptional regulator
HEC78_RS11075	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HEC78_RS11095	COG0668	transmembrane transport
HEC78_RS11100	COG3182	Iron-regulated membrane protein
HEC78_RS11120	COG2840	Smr protein MutS2
HEC78_RS11125	COG0840	transmembrane signaling receptor activity
HEC78_RS11135	COG0513	Belongs to the DEAD box helicase family
HEC78_RS11155	COG2076	Multidrug Resistance protein
HEC78_RS11170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC78_RS11170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEC78_RS11170	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEC78_RS11170	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEC78_RS11180	COG3042	response to heat
HEC78_RS11185	COG3187	Heat shock protein
HEC78_RS11190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEC78_RS11195	COG2911	Protein conserved in bacteria
HEC78_RS11205	COG3784	Protein of unknown function (DUF1318)
HEC78_RS11220	COG1643	Atp-dependent helicase
HEC78_RS11225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEC78_RS11230	COG3038	cytochrome b561
HEC78_RS11235	COG0500	methyltransferase
HEC78_RS11245	COG0765	amino acid transport
HEC78_RS11255	COG0765	amino acid transport
HEC78_RS11260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC78_RS11295	COG0840	transmembrane signaling receptor activity
HEC78_RS11300	COG0583	DNA-binding transcription factor activity
HEC78_RS11305	COG5383	Protein conserved in bacteria
HEC78_RS11310	COG2272	Belongs to the type-B carboxylesterase lipase family
HEC78_RS11315	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HEC78_RS11320	COG2353	YceI-like domain
HEC78_RS11325	COG1304	FMN binding
HEC78_RS11335	COG1349	DNA-binding transcription factor activity
HEC78_RS11340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEC78_RS11345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS11350	COG0434	BtpA family
HEC78_RS11355	COG3775	system Galactitol-specific IIC component
HEC78_RS11360	COG3414	Phosphotransferase system galactitol-specific IIB component
HEC78_RS11370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC78_RS11375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC78_RS11380	COG1275	C4-dicarboxylate transporter malic acid transport protein
HEC78_RS11385	COG0500	methyltransferase
HEC78_RS11395	COG3135	benzoate transporter
HEC78_RS11400	COG1396	sequence-specific DNA binding
HEC78_RS11405	COG0826	peptidase U32
HEC78_RS11430	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEC78_RS11435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEC78_RS11475	COG3238	Protein conserved in bacteria
HEC78_RS11485	COG2130	NADP-dependent
HEC78_RS11490	COG1802	Transcriptional regulator
HEC78_RS11495	COG4772	TonB-dependent receptor
HEC78_RS11500	COG3391	amine dehydrogenase activity
HEC78_RS11530	COG2181	nitrate reductase activity
HEC78_RS11535	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HEC78_RS11540	COG1140	nitrate reductase beta subunit
HEC78_RS11545	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HEC78_RS11585	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS11590	COG2864	formate dehydrogenase
HEC78_RS11595	COG1064	alcohol dehydrogenase
HEC78_RS11615	COG1764	response to oxidative stress
HEC78_RS11640	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEC78_RS11655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HEC78_RS11660	COG1757	Na H antiporter
HEC78_RS11665	COG1609	Transcriptional regulator
HEC78_RS11705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEC78_RS11730	COG2271	Major facilitator Superfamily
HEC78_RS11735	COG1063	alcohol dehydrogenase
HEC78_RS11740	COG2186	Transcriptional regulator
HEC78_RS11750	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HEC78_RS11755	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEC78_RS11780	COG1773	rubredoxin
HEC78_RS11805	COG3781	membrane
HEC78_RS11820	COG1012	belongs to the aldehyde dehydrogenase family
HEC78_RS11825	COG0583	DNA-binding transcription factor activity
HEC78_RS11860	COG2814	Major facilitator Superfamily
HEC78_RS11870	COG3111	PFAM Bacterial OB fold (BOF) protein
HEC78_RS11875	COG1546	Belongs to the CinA family
HEC78_RS11880	COG3729	General stress protein
HEC78_RS11890	COG4221	oxidoreductase activity
HEC78_RS11895	COG1802	Transcriptional regulator
HEC78_RS11905	COG0246	Mannitol dehydrogenase
HEC78_RS11910	COG0477	Major facilitator Superfamily
HEC78_RS11915	COG1063	alcohol dehydrogenase
HEC78_RS11935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC78_RS11950	COG0243	molybdopterin cofactor binding
HEC78_RS11955	COG0243	molybdopterin cofactor binding
HEC78_RS11960	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS11965	COG3302	dmso reductase anchor subunit
HEC78_RS12005	COG1940	carbohydrate kinase activity
HEC78_RS12010	COG0583	DNA-binding transcription factor activity
HEC78_RS12015	COG2814	Major facilitator Superfamily
HEC78_RS12025	COG3591	Belongs to the peptidase S1B family
HEC78_RS12040	COG0628	permease
HEC78_RS12045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HEC78_RS12050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HEC78_RS12060	COG0531	amino acid
HEC78_RS12065	COG3136	membrane protein required for alginate biosynthesis
HEC78_RS12070	COG0745	RESPONSE REGULATOR receiver
HEC78_RS12080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC78_RS12085	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HEC78_RS12090	COG2205	protein histidine kinase activity
HEC78_RS12115	COG5339	Protein conserved in bacteria
HEC78_RS12130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEC78_RS12135	COG0673	inositol 2-dehydrogenase activity
HEC78_RS12185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEC78_RS12195	COG0625	glutathione transferase activity
HEC78_RS12215	COG3895	Periplasmic Protein
HEC78_RS12240	COG1566	PFAM secretion protein HlyD family protein
HEC78_RS12255	COG4989	oxidoreductase activity
HEC78_RS12260	COG3313	Fe-S protein
HEC78_RS12265	COG1309	transcriptional regulator
HEC78_RS12270	COG1902	pentaerythritol trinitrate reductase activity
HEC78_RS12285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEC78_RS12290	COG0791	NLP P60 protein
HEC78_RS12310	COG0583	DNA-binding transcription factor activity
HEC78_RS12315	COG2814	Major facilitator Superfamily
HEC78_RS12320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEC78_RS12325	COG0307	riboflavin synthase, alpha
HEC78_RS12505	COG0789	Transcriptional regulator
HEC78_RS12510	COG3272	Protein of unknown function (DUF1722)
HEC78_RS12545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS12555	COG2267	carboxylic ester hydrolase activity
HEC78_RS12560	COG0531	amino acid
HEC78_RS12580	COG4238	major outer membrane lipoprotein
HEC78_RS12585	COG1376	ErfK ybiS ycfS ynhG family protein
HEC78_RS12600	COG0719	Fe-S assembly protein
HEC78_RS12605	COG0396	ATPase activity
HEC78_RS12610	COG0719	Fe-S assembly protein
HEC78_RS12615	COG0316	Belongs to the HesB IscA family
HEC78_RS12630	COG2050	protein possibly involved in aromatic compounds catabolism
HEC78_RS12635	COG0277	FAD linked oxidase domain protein
HEC78_RS12635	COG0247	lactate metabolic process
HEC78_RS12640	COG0628	permease
HEC78_RS12655	COG0738	Major facilitator superfamily
HEC78_RS12660	COG2271	Major facilitator Superfamily
HEC78_RS12675	COG4670	ketone body catabolic process
HEC78_RS12680	COG1960	acyl-CoA dehydrogenase activity
HEC78_RS12685	COG2207	Transcriptional regulator
HEC78_RS12685	COG1917	Cupin 2, conserved barrel domain protein
HEC78_RS12690	COG2086	electron transfer activity
HEC78_RS12695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEC78_RS12700	COG0644	oxidoreductase
HEC78_RS12705	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HEC78_RS12710	COG0318	PFAM AMP-dependent synthetase and ligase
HEC78_RS12715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEC78_RS12715	COG0574	Belongs to the PEP-utilizing enzyme family
HEC78_RS12730	COG4256	Hemin uptake protein
HEC78_RS12750	COG0791	NLP P60 protein
HEC78_RS12760	COG0386	Belongs to the glutathione peroxidase family
HEC78_RS12825	COG3137	Salt-induced outer membrane protein
HEC78_RS12830	COG1105	Belongs to the carbohydrate kinase PfkB family
HEC78_RS12840	COG3001	Fructosamine kinase
HEC78_RS12850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC78_RS12855	COG1988	membrane-bound metal-dependent
HEC78_RS12870	COG0753	catalase activity
HEC78_RS12880	COG1486	melibiose metabolic process
HEC78_RS12900	COG1447	Phosphotransferase system cellobiose-specific component IIA
HEC78_RS12905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC78_RS12910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC78_RS12915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC78_RS12930	COG3678	ATP-independent chaperone mediated protein folding
HEC78_RS12965	COG0494	nUDIX hydrolase
HEC78_RS12980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEC78_RS12990	COG0778	Nitroreductase
HEC78_RS12995	COG0616	signal peptide processing
HEC78_RS13000	COG0252	asparaginase activity
HEC78_RS13005	COG1335	isochorismatase
HEC78_RS13010	COG3139	Protein of unknown function (DUF1315)
HEC78_RS13030	COG0656	L-ascorbic acid biosynthetic process
HEC78_RS13035	COG0641	radical SAM
HEC78_RS13040	COG3713	MltA-interacting MipA family protein
HEC78_RS13045	COG2766	serine protein kinase
HEC78_RS13065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC78_RS13080	COG2207	Transcriptional regulator
HEC78_RS13085	COG2807	transmembrane transport
HEC78_RS13090	COG3189	MarR family transcriptional regulator
HEC78_RS13100	COG3042	response to heat
HEC78_RS13110	COG2261	transglycosylase associated protein
HEC78_RS13125	COG3615	Tellurite resistance protein tehB
HEC78_RS13135	COG1605	Chorismate mutase
HEC78_RS13150	COG0789	Transcriptional regulator
HEC78_RS13165	COG3443	Belongs to the bacterial solute-binding protein 9 family
HEC78_RS13180	COG0668	transmembrane transport
HEC78_RS13185	COG1124	(ABC) transporter
HEC78_RS13215	COG3038	cytochrome b561
HEC78_RS13225	COG0071	Belongs to the small heat shock protein (HSP20) family
HEC78_RS13275	COG3021	interspecies interaction between organisms
HEC78_RS13310	COG0538	isocitrate dehydrogenase activity
HEC78_RS13340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEC78_RS13355	COG2850	peptidyl-arginine hydroxylation
HEC78_RS13385	COG1177	transmembrane transport
HEC78_RS13405	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEC78_RS13410	COG1136	(ABC) transporter
HEC78_RS13415	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEC78_RS13420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEC78_RS13425	COG1388	LysM domain
HEC78_RS13425	COG1376	ErfK ybiS ycfS ynhG family protein
HEC78_RS13435	COG1309	transcriptional regulator
HEC78_RS13440	COG3134	Outer membrane lipoprotein
HEC78_RS13445	COG1252	NADH dehydrogenase
HEC78_RS13470	COG5633	Lipoprotein
HEC78_RS13475	COG0537	adenosine 5'-monophosphoramidase activity
HEC78_RS13480	COG4773	Receptor
HEC78_RS13490	COG0084	hydrolase, TatD family'
HEC78_RS13495	COG0470	DNA polymerase III
HEC78_RS13505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEC78_RS13510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEC78_RS13515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC78_RS13535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEC78_RS13560	COG0564	pseudouridine synthase activity
HEC78_RS13565	COG1530	ribonuclease E activity
HEC78_RS13655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC78_RS13665	COG2999	glutathione oxidoreductase activity
HEC78_RS13700	COG3038	cytochrome b561
HEC78_RS13715	COG1560	Kdo2-lipid A biosynthetic process
HEC78_RS13730	COG5645	(Lipo)protein
HEC78_RS13735	COG2943	transferase activity, transferring hexosyl groups
HEC78_RS13750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC78_RS13810	COG3381	protein complex oligomerization
HEC78_RS13880	COG0673	inositol 2-dehydrogenase activity
HEC78_RS13885	COG2814	Major facilitator Superfamily
HEC78_RS13905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEC78_RS13910	COG1737	Transcriptional regulator
HEC78_RS13915	COG1702	phosphate starvation-inducible protein PhoH
HEC78_RS13935	COG1309	transcriptional regulator
HEC78_RS13940	COG3729	General stress protein
HEC78_RS13960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEC78_RS13965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEC78_RS13965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEC78_RS13970	COG4232	protein-disulfide reductase activity
HEC78_RS14015	COG3971	2-oxopent-4-enoate hydratase activity
HEC78_RS14025	COG3384	dioxygenase
HEC78_RS14030	COG1012	belongs to the aldehyde dehydrogenase family
HEC78_RS14040	COG1846	Transcriptional regulator
HEC78_RS14045	COG2368	4-hydroxyphenylacetate
HEC78_RS14060	COG0745	RESPONSE REGULATOR receiver
HEC78_RS14065	COG2205	protein histidine kinase activity
HEC78_RS14115	COG0670	Belongs to the BI1 family
HEC78_RS14135	COG1881	PFAM PEBP family protein
HEC78_RS14150	COG1832	CoA-binding protein
HEC78_RS14165	COG0210	DNA helicase
HEC78_RS14170	COG3304	Inner membrane component domain
HEC78_RS14175	COG1289	transmembrane transporter activity
HEC78_RS14180	COG3070	regulator of competence-specific genes
HEC78_RS14200	COG1067	ATP-dependent peptidase activity
HEC78_RS14210	COG3130	regulation of translation
HEC78_RS14215	COG3009	Protein conserved in bacteria
HEC78_RS14220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEC78_RS14220	COG3008	intermembrane lipid transfer
HEC78_RS14225	COG2995	paraquat-inducible protein a
HEC78_RS14230	COG0488	(ABC) transporter
HEC78_RS14240	COG0633	Ferredoxin
HEC78_RS14240	COG3217	Mosc domain protein beta barrel domain protein
HEC78_RS14255	COG0308	aminopeptidase N
HEC78_RS14265	COG0017	Asparaginyl-tRNA synthetase
HEC78_RS14270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC78_RS14275	COG1448	Aminotransferase
HEC78_RS14280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEC78_RS14285	COG3108	Peptidase M15
HEC78_RS14290	COG2989	Protein conserved in bacteria
HEC78_RS14300	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HEC78_RS14310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEC78_RS14315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEC78_RS14320	COG3173	Aminoglycoside phosphotransferase
HEC78_RS14335	COG3214	Protein conserved in bacteria
HEC78_RS14350	COG0658	competence protein
HEC78_RS14350	COG2333	competence protein COMEC
HEC78_RS14360	COG0539	negative regulation of cytoplasmic translation
HEC78_RS14370	COG0501	Belongs to the peptidase M48B family
HEC78_RS14385	COG2323	membrane
HEC78_RS14390	COG1944	ATP diphosphatase activity
HEC78_RS14395	COG2116	formate transmembrane transporter activity
HEC78_RS14400	COG1882	Formate acetyltransferase
HEC78_RS14420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC78_RS14425	COG0531	amino acid
HEC78_RS14435	COG3302	dmso reductase anchor subunit
HEC78_RS14440	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS14445	COG0243	molybdopterin cofactor binding
HEC78_RS14455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEC78_RS14475	COG0492	ferredoxin-NADP+ reductase activity
HEC78_RS14480	COG4988	ABC transporter
HEC78_RS14485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEC78_RS14505	COG0583	DNA-binding transcription factor activity
HEC78_RS14515	COG1335	isochorismatase
HEC78_RS14535	COG0542	response to heat
HEC78_RS14545	COG1278	Cold shock
HEC78_RS14550	COG0577	efflux transmembrane transporter activity
HEC78_RS14550	COG1136	(ABC) transporter
HEC78_RS14555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC78_RS14560	COG2990	Protein conserved in bacteria
HEC78_RS14565	COG3593	DNA synthesis involved in DNA repair
HEC78_RS14570	COG2431	L-lysine efflux transmembrane transporter activity
HEC78_RS14580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC78_RS14585	COG0028	Belongs to the TPP enzyme family
HEC78_RS14590	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HEC78_RS14595	COG0702	epimerase
HEC78_RS14600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC78_RS14605	COG3023	N-Acetylmuramoyl-L-alanine amidase
HEC78_RS14620	COG1126	abc transporter atp-binding protein
HEC78_RS14625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC78_RS14630	COG4215	(ABC) transporter
HEC78_RS14635	COG4160	amino acid transport
HEC78_RS14640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC78_RS14670	COG1177	transmembrane transport
HEC78_RS14675	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEC78_RS14680	COG3842	ATPase activity
HEC78_RS14685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEC78_RS14725	COG3226	Transcriptional regulator
HEC78_RS14730	COG0738	Major facilitator superfamily
HEC78_RS14735	COG0561	phosphatase activity
HEC78_RS14740	COG2814	Major facilitator Superfamily
HEC78_RS14745	COG0671	phosphoesterase, PA-phosphatase related
HEC78_RS14750	COG1349	DNA-binding transcription factor activity
HEC78_RS14755	COG1686	Belongs to the peptidase S11 family
HEC78_RS14760	COG0625	glutathione transferase activity
HEC78_RS14765	COG2133	pyrroloquinoline quinone binding
HEC78_RS14790	COG0747	negative chemotaxis
HEC78_RS14815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC78_RS14820	COG1882	Formate acetyltransferase
HEC78_RS14825	COG0561	phosphatase activity
HEC78_RS14835	COG0488	(ABC) transporter
HEC78_RS14840	COG1376	ErfK ybiS ycfS ynhG family protein
HEC78_RS14845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HEC78_RS14860	COG2194	sulfuric ester hydrolase activity
HEC78_RS14865	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HEC78_RS14880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC78_RS14885	COG0765	amino acid transport
HEC78_RS14890	COG1126	abc transporter atp-binding protein
HEC78_RS14895	COG0668	transmembrane transport
HEC78_RS14905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEC78_RS14915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEC78_RS14925	COG0513	Belongs to the DEAD box helicase family
HEC78_RS14930	COG1309	transcriptional regulator
HEC78_RS14935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC78_RS14940	COG1131	(ABC) transporter
HEC78_RS14945	COG0842	Transport permease protein
HEC78_RS14950	COG0842	Transport permease protein
HEC78_RS14960	COG3568	Endonuclease Exonuclease Phosphatase
HEC78_RS14965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC78_RS14970	COG0392	lysyltransferase activity
HEC78_RS14985	COG0670	Belongs to the BI1 family
HEC78_RS14995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEC78_RS15005	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEC78_RS15030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEC78_RS15055	COG1881	PFAM PEBP family protein
HEC78_RS15085	COG4677	pectinesterase activity
HEC78_RS15095	COG0561	phosphatase activity
HEC78_RS15105	COG4149	molybdate abc transporter
HEC78_RS15110	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEC78_RS15120	COG3585	molybdate ion transport
HEC78_RS15120	COG2005	Transcriptional regulator
HEC78_RS15125	COG1119	ATPase activity
HEC78_RS15150	COG2017	converts alpha-aldose to the beta-anomer
HEC78_RS15160	COG1120	ATPase activity
HEC78_RS15165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC78_RS15175	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HEC78_RS15180	COG5016	pyruvate
HEC78_RS15180	COG0511	ligase activity, forming carbon-carbon bonds
HEC78_RS15190	COG0490	domain, Protein
HEC78_RS15190	COG0471	metal ion transport
HEC78_RS15195	COG0583	DNA-binding transcription factor activity
HEC78_RS15200	COG0583	DNA-binding transcription factor activity
HEC78_RS15210	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC78_RS15210	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC78_RS15215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEC78_RS15225	COG1230	cation diffusion facilitator family transporter
HEC78_RS15270	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HEC78_RS15275	COG2885	chlorophyll binding
HEC78_RS15285	COG3064	Membrane
HEC78_RS15290	COG0848	biopolymer transport protein
HEC78_RS15295	COG0811	peptide transport
HEC78_RS15300	COG0824	Thioesterase
HEC78_RS15305	COG3790	cyd operon protein YbgE
HEC78_RS15310	COG4890	Cyd operon protein YbgT
HEC78_RS15315	COG1294	oxidase, subunit
HEC78_RS15320	COG1271	oxidase subunit
HEC78_RS15325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC78_RS15335	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEC78_RS15340	COG0567	Dehydrogenase, E1 component
HEC78_RS15355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEC78_RS15375	COG3180	Ammonia monooxygenase
HEC78_RS15390	COG1984	allophanate hydrolase subunit 2
HEC78_RS15395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HEC78_RS15440	COG2205	protein histidine kinase activity
HEC78_RS15445	COG0745	RESPONSE REGULATOR receiver
HEC78_RS15455	COG1982	Orn Lys Arg decarboxylase major
HEC78_RS15460	COG0531	amino acid
HEC78_RS15470	COG0033	Phosphoglucomutase
HEC78_RS15480	COG0596	Alpha beta hydrolase
HEC78_RS15495	COG0735	belongs to the Fur family
HEC78_RS15500	COG0583	DNA-binding transcription factor activity
HEC78_RS15505	COG1053	succinate dehydrogenase
HEC78_RS15545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEC78_RS15550	COG1940	carbohydrate kinase activity
HEC78_RS15550	COG1846	Transcriptional regulator
HEC78_RS15555	COG0647	UMP catabolic process
HEC78_RS15560	COG0367	asparagine synthase
HEC78_RS15600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC78_RS15610	COG1702	phosphate starvation-inducible protein PhoH
HEC78_RS15635	COG0765	amino acid transport
HEC78_RS15640	COG0765	amino acid transport
HEC78_RS15645	COG1126	abc transporter atp-binding protein
HEC78_RS15660	COG2888	peptidyl-tyrosine sulfation
HEC78_RS15665	COG3290	protein histidine kinase activity
HEC78_RS15665	COG3829	transcription factor binding
HEC78_RS15695	COG1466	dna polymerase III delta subunit
HEC78_RS15705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEC78_RS15715	COG0799	negative regulation of ribosome biogenesis
HEC78_RS15725	COG0768	penicillin binding
HEC78_RS15730	COG0772	Belongs to the SEDS family
HEC78_RS15735	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEC78_RS15740	COG1686	Belongs to the peptidase S11 family
HEC78_RS15755	COG0583	DNA-binding transcription factor activity
HEC78_RS15770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC78_RS15790	COG3069	C4-dicarboxylate transmembrane transporter activity
HEC78_RS15795	COG4565	transcriptional regulatory protein
HEC78_RS15805	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HEC78_RS15815	COG2301	Belongs to the HpcH HpaI aldolase family
HEC78_RS15820	COG3051	citrate lyase alpha subunit
HEC78_RS15835	COG0471	metal ion transport
HEC78_RS15840	COG3719	Belongs to the RNase T2 family
HEC78_RS15845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEC78_RS15850	COG1063	alcohol dehydrogenase
HEC78_RS15870	COG0243	molybdopterin cofactor binding
HEC78_RS15890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEC78_RS15895	COG0583	DNA-binding transcription factor activity
HEC78_RS15900	COG3969	phosphoadenosine phosphosulfate
HEC78_RS15905	COG1475	DNA binding
HEC78_RS15910	COG0436	Aminotransferase
HEC78_RS15915	COG0371	Dehydrogenase
HEC78_RS15920	COG2879	small protein
HEC78_RS15925	COG1966	Carbon starvation protein
HEC78_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
HEC78_RS15940	COG1535	isochorismatase
HEC78_RS15940	COG3433	isochorismatase activity
HEC78_RS15945	COG1021	2,3-dihydroxybenzoate-AMP ligase
HEC78_RS15950	COG1169	isochorismate synthase
HEC78_RS15955	COG4592	Periplasmic binding protein
HEC78_RS15965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC78_RS15970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC78_RS15975	COG1120	ATPase activity
HEC78_RS15980	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HEC78_RS15985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEC78_RS15985	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HEC78_RS15990	COG3251	PFAM MbtH domain protein
HEC78_RS15995	COG2382	esterase
HEC78_RS16000	COG4771	TonB-dependent receptor
HEC78_RS16005	COG2977	Belongs to the P-Pant transferase superfamily
HEC78_RS16030	COG2315	Protein conserved in bacteria
HEC78_RS16045	COG0668	transmembrane transport
HEC78_RS16050	COG1113	amino acid transport
HEC78_RS16060	COG3059	membrane
HEC78_RS16070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC78_RS16075	COG2207	Transcriptional regulator
HEC78_RS16095	COG2246	polysaccharide biosynthetic process
HEC78_RS16100	COG0463	Glycosyl transferase, family 2
HEC78_RS16180	COG2501	S4 domain
HEC78_RS16185	COG1988	membrane-bound metal-dependent
HEC78_RS16205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEC78_RS16215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEC78_RS16220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HEC78_RS16225	COG0549	Belongs to the carbamate kinase family
HEC78_RS16235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC78_RS16240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC78_RS16245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HEC78_RS16250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEC78_RS16255	COG3257	ureidoglycine aminohydrolase activity
HEC78_RS16260	COG1929	Belongs to the glycerate kinase type-1 family
HEC78_RS16265	COG2233	PERMEase
HEC78_RS16275	COG1953	Uracil, thiamine, allantoin
HEC78_RS16285	COG2084	Dehydrogenase
HEC78_RS16290	COG3622	Belongs to the hyi family
HEC78_RS16295	COG3960	tartronate-semialdehyde synthase activity
HEC78_RS16330	COG1464	Belongs to the NlpA lipoprotein family
HEC78_RS16340	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEC78_RS16345	COG4181	ATPase activity
HEC78_RS16350	COG2755	lipolytic protein G-D-S-L family
HEC78_RS16355	COG0300	oxidoreductase activity
HEC78_RS16360	COG3118	belongs to the thioredoxin family
HEC78_RS16365	COG0390	transport system, permease component
HEC78_RS16370	COG4619	ABC transporter
HEC78_RS16375	COG0330	HflC and HflK could
HEC78_RS16380	COG1585	Membrane protein implicated in regulation of membrane protease activity
HEC78_RS16390	COG2217	Heavy metal translocating P-type atpase
HEC78_RS16400	COG3735	TraB family
HEC78_RS16415	COG2223	nitrite transmembrane transporter activity
HEC78_RS16420	COG4651	solute:proton antiporter activity
HEC78_RS16420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEC78_RS16425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS16470	COG2832	Protein of unknown function (DUF454)
HEC78_RS16475	COG3923	Primosomal replication protein n
HEC78_RS16485	COG5464	transposase or invertase
HEC78_RS16490	COG3264	Mechanosensitive ion channel
HEC78_RS16490	COG1196	nuclear chromosome segregation
HEC78_RS16495	COG1309	transcriptional regulator
HEC78_RS16500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC78_RS16505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC78_RS16520	COG0110	maltose O-acetyltransferase activity
HEC78_RS16540	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HEC78_RS16550	COG3695	enzyme binding
HEC78_RS16555	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HEC78_RS16560	COG1946	Acyl-CoA thioesterase
HEC78_RS16565	COG0004	ammonium transporteR
HEC78_RS16570	COG0347	Belongs to the P(II) protein family
HEC78_RS16575	COG1132	(ABC) transporter
HEC78_RS16580	COG1132	(ABC) transporter
HEC78_RS16585	COG1522	sequence-specific DNA binding
HEC78_RS16600	COG4533	DNA binding
HEC78_RS16610	COG0824	Thioesterase
HEC78_RS16615	COG1555	photosystem II stabilization
HEC78_RS16620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEC78_RS16630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEC78_RS16650	COG0271	Belongs to the BolA IbaG family
HEC78_RS16655	COG3056	Lipoprotein
HEC78_RS16660	COG2223	nitrite transmembrane transporter activity
HEC78_RS16665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEC78_RS16670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEC78_RS16675	COG1845	cytochrome c oxidase, subunit III
HEC78_RS16680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEC78_RS16705	COG2814	Major facilitator Superfamily
HEC78_RS16735	COG2188	Transcriptional regulator
HEC78_RS16770	COG0142	geranyltranstransferase activity
HEC78_RS16780	COG0667	Aldo Keto reductase
HEC78_RS16785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HEC78_RS16805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEC78_RS16805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEC78_RS16815	COG4238	major outer membrane lipoprotein
HEC78_RS16845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEC78_RS16855	COG1862	Preprotein translocase
HEC78_RS16875	COG0450	alkyl hydroperoxide reductase
HEC78_RS16885	COG0366	Alpha amylase catalytic
HEC78_RS16900	COG5002	protein histidine kinase activity
HEC78_RS16910	COG0420	3'-5' exonuclease activity
HEC78_RS16915	COG0419	ATPase involved in DNA repair
HEC78_RS16920	COG2814	Major facilitator Superfamily
HEC78_RS16925	COG1940	carbohydrate kinase activity
HEC78_RS16940	COG4126	flavin adenine dinucleotide binding
HEC78_RS16960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEC78_RS16965	COG3706	GGDEF domain
HEC78_RS17010	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HEC78_RS17015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEC78_RS17030	COG0113	porphobilinogen synthase activity
HEC78_RS17065	COG1280	lysine exporter protein (LysE YggA)
HEC78_RS17085	COG1294	oxidase, subunit
HEC78_RS17090	COG1271	oxidase subunit
HEC78_RS17110	COG2814	Major facilitator Superfamily
HEC78_RS17120	COG0789	Transcriptional regulator
HEC78_RS17175	COG2200	EAL domain
HEC78_RS17190	COG3539	Fimbrial protein
HEC78_RS17195	COG3121	Chaperone
HEC78_RS17200	COG3188	usher protein
HEC78_RS17220	COG2246	polysaccharide biosynthetic process
HEC78_RS17225	COG0463	Glycosyl transferase, family 2
HEC78_RS17340	COG3772	lysozyme
HEC78_RS17350	COG0484	heat shock protein binding
HEC78_RS17405	COG0305	Participates in initiation and elongation during chromosome replication
HEC78_RS17490	COG4712	double-strand break repair protein
HEC78_RS17545	COG0582	viral genome integration into host DNA
HEC78_RS17680	COG3567	Phage-associated protein, HI1409 family
HEC78_RS17685	COG1783	phage Terminase large subunit
HEC78_RS17770	COG0305	Participates in initiation and elongation during chromosome replication
HEC78_RS17795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEC78_RS17870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEC78_RS17880	COG0582	viral genome integration into host DNA
HEC78_RS17920	COG2195	Cleaves the N-terminal amino acid of tripeptides
HEC78_RS17925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEC78_RS17930	COG1690	Belongs to the RtcB family
HEC78_RS17940	COG3034	peptidoglycan biosynthetic process
HEC78_RS17945	COG0121	glutamine amidotransferase
HEC78_RS17965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC78_RS17995	COG1522	sequence-specific DNA binding
HEC78_RS18125	COG3501	Rhs element vgr protein
HEC78_RS18170	COG2885	chlorophyll binding
HEC78_RS18170	COG3047	cAMP biosynthetic process
HEC78_RS18275	COG2226	methyltransferase
HEC78_RS18285	COG0741	lytic transglycosylase activity
HEC78_RS18285	COG1388	LysM domain
HEC78_RS18290	COG2226	methyltransferase
HEC78_RS18300	COG2814	Major facilitator Superfamily
HEC78_RS18305	COG0583	DNA-binding transcription factor activity
HEC78_RS18310	COG0656	L-ascorbic acid biosynthetic process
HEC78_RS18345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HEC78_RS18370	COG1720	tRNA m6t6A37 methyltransferase activity
HEC78_RS18380	COG3015	lipoprotein NlpE involved in copper resistance
HEC78_RS18385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEC78_RS18400	COG4568	rho-dependent transcription termination
HEC78_RS18410	COG0346	lactoylglutathione lyase activity
HEC78_RS18475	COG0575	Belongs to the CDS family
HEC78_RS18525	COG0477	Major facilitator Superfamily
HEC78_RS18535	COG3835	regulator
HEC78_RS18555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEC78_RS18560	COG2860	membrane
HEC78_RS18590	COG3539	Fimbrial protein
HEC78_RS18595	COG3539	Fimbrial protein
HEC78_RS18600	COG3121	Chaperone
HEC78_RS18605	COG3188	usher protein
HEC78_RS18620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEC78_RS18625	COG1120	ATPase activity
HEC78_RS18630	COG4774	siderophore transport
HEC78_RS18635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEC78_RS18640	COG1643	Atp-dependent helicase
HEC78_RS18645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HEC78_RS18670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEC78_RS18695	COG3121	Chaperone
HEC78_RS18700	COG3188	usher protein
HEC78_RS18705	COG3539	Fimbrial protein
HEC78_RS18725	COG0726	polysaccharide deacetylase
HEC78_RS18730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS18735	COG0842	Transport permease protein
HEC78_RS18740	COG1131	(ABC) transporter
HEC78_RS18745	COG0288	reversible hydration of carbon dioxide
HEC78_RS18755	COG4993	Dehydrogenase
HEC78_RS18760	COG2132	Multicopper oxidase
HEC78_RS18780	COG1349	DNA-binding transcription factor activity
HEC78_RS18810	COG3064	Membrane
HEC78_RS18825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC78_RS18830	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEC78_RS18835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEC78_RS18850	COG2211	Major facilitator Superfamily
HEC78_RS18855	COG3940	Belongs to the glycosyl hydrolase 43 family
HEC78_RS18860	COG3725	Membrane protein required for beta-lactamase induction
HEC78_RS18875	COG4969	Belongs to the N-Me-Phe pilin family
HEC78_RS18880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEC78_RS18885	COG1459	type II secretion system
HEC78_RS18920	COG0494	nUDIX hydrolase
HEC78_RS18940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEC78_RS18945	COG0849	cell division
HEC78_RS18970	COG0772	Belongs to the SEDS family
HEC78_RS18985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEC78_RS18995	COG0768	penicillin binding
HEC78_RS19090	COG0586	Pfam SNARE associated Golgi protein
HEC78_RS19130	COG0417	DNA replication proofreading
HEC78_RS19150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HEC78_RS19160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEC78_RS19195	COG3119	arylsulfatase activity
HEC78_RS19215	COG2271	Major facilitator Superfamily
HEC78_RS19225	COG0644	oxidoreductase
HEC78_RS19335	COG0511	ligase activity, forming carbon-carbon bonds
HEC78_RS19335	COG5016	pyruvate
HEC78_RS19340	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HEC78_RS19370	COG1047	Peptidyl-prolyl cis-trans
HEC78_RS19385	COG0196	riboflavin kinase activity
HEC78_RS19410	COG0583	DNA-binding transcription factor activity
HEC78_RS19430	COG0641	radical SAM
HEC78_RS19435	COG3119	arylsulfatase activity
HEC78_RS19445	COG0737	Belongs to the 5'-nucleotidase family
HEC78_RS19480	COG3121	Chaperone
HEC78_RS19485	COG3539	Fimbrial protein
HEC78_RS19500	COG3188	usher protein
HEC78_RS19565	COG4735	regulation of single-species biofilm formation
HEC78_RS19570	COG1584	GPR1 FUN34 yaaH family protein
HEC78_RS19575	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEC78_RS19585	COG1115	amino acid carrier protein
HEC78_RS19595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEC78_RS19605	COG0527	aspartate kinase activity
HEC78_RS19605	COG0460	homoserine dehydrogenase
HEC78_RS19615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HEC78_RS19625	COG0745	RESPONSE REGULATOR receiver
HEC78_RS19645	COG3121	Chaperone
HEC78_RS19665	COG4452	Inner membrane protein CreD
HEC78_RS19670	COG2205	protein histidine kinase activity
HEC78_RS19675	COG0745	RESPONSE REGULATOR receiver
HEC78_RS19680	COG3045	CreA protein
HEC78_RS19685	COG2207	Transcriptional regulator
HEC78_RS19685	COG3708	Transcriptional regulator
HEC78_RS19710	COG0488	(ABC) transporter
HEC78_RS19725	COG0560	Phosphoserine phosphatase
HEC78_RS19730	COG3726	membrane protein affecting hemolysin expression
HEC78_RS19765	COG1328	CTP reductase activity
HEC78_RS19770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC78_RS19775	COG0084	hydrolase, TatD family'
HEC78_RS19780	COG4667	esterase of the alpha-beta hydrolase superfamily
HEC78_RS19790	COG2823	Periplasmic or secreted lipoprotein
HEC78_RS19800	COG1011	Hydrolase
HEC78_RS19810	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HEC78_RS19840	COG3706	GGDEF domain
HEC78_RS19845	COG4114	ferric iron reductase
HEC78_RS19850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC78_RS19855	COG2197	response regulator
HEC78_RS19860	COG2197	response regulator
HEC78_RS19865	COG2966	Psort location CytoplasmicMembrane, score
HEC78_RS19880	COG1484	DNA-dependent DNA replication
HEC78_RS19895	COG0840	transmembrane signaling receptor activity
HEC78_RS19900	COG1966	Carbon starvation protein
HEC78_RS19905	COG2879	small protein
HEC78_RS19910	COG0523	cobalamin synthesis protein
HEC78_RS19920	COG1280	lysine exporter protein (LysE YggA)
HEC78_RS19925	COG3586	endonuclease activity
HEC78_RS19940	COG1012	belongs to the aldehyde dehydrogenase family
HEC78_RS19945	COG5464	transposase or invertase
HEC78_RS19955	COG2733	membrane
HEC78_RS19960	COG0477	Major facilitator Superfamily
HEC78_RS19965	COG3366	ferrous iron transmembrane transporter activity
HEC78_RS19970	COG0700	Nucleoside recognition
HEC78_RS19975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEC78_RS19980	COG0583	DNA-binding transcription factor activity
HEC78_RS20000	COG2186	Transcriptional regulator
HEC78_RS20005	COG0412	Dienelactone hydrolase
HEC78_RS20030	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HEC78_RS20100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEC78_RS20105	COG0464	growth
HEC78_RS20110	COG1404	Belongs to the peptidase S8 family
HEC78_RS20115	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HEC78_RS20125	COG0582	viral genome integration into host DNA
HEC78_RS20135	COG1064	alcohol dehydrogenase
HEC78_RS20140	COG3265	gluconokinase activity
HEC78_RS20145	COG1063	alcohol dehydrogenase
HEC78_RS20150	COG1028	Short-chain dehydrogenase reductase Sdr
HEC78_RS20155	COG2610	gluconate transmembrane transporter activity
HEC78_RS20160	COG1609	Transcriptional regulator
HEC78_RS20165	COG0795	lipopolysaccharide-transporting ATPase activity
HEC78_RS20170	COG0795	lipopolysaccharide-transporting ATPase activity
HEC78_RS20180	COG2927	DNA polymerase III (CHI subunit)
HEC78_RS20225	COG2731	YhcH YjgK YiaL family protein
HEC78_RS20245	COG1288	antiporter activity
HEC78_RS20250	COG1438	arginine binding
HEC78_RS20295	COG1263	PTS System
HEC78_RS20295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC78_RS20300	COG0366	Alpha amylase catalytic
HEC78_RS20315	COG2026	Addiction module toxin, RelE StbE family
HEC78_RS20320	COG3077	Addiction module antitoxin, RelB DinJ family
HEC78_RS20325	COG3711	transcriptional antiterminator
HEC78_RS20325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC78_RS20340	COG3964	amidohydrolase
HEC78_RS20375	COG0312	modulator of DNA gyrase
HEC78_RS20385	COG1082	Xylose isomerase domain protein TIM barrel
HEC78_RS20395	COG2814	Major facilitator Superfamily
HEC78_RS20400	COG0673	inositol 2-dehydrogenase activity
HEC78_RS20405	COG3962	Belongs to the TPP enzyme family
HEC78_RS20410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS20420	COG1082	Xylose isomerase domain protein TIM barrel
HEC78_RS20425	COG5520	Belongs to the glycosyl hydrolase 30 family
HEC78_RS20455	COG3718	enzyme involved in inositol metabolism
HEC78_RS20460	COG0477	Major facilitator Superfamily
HEC78_RS20460	COG2814	Major facilitator Superfamily
HEC78_RS20465	COG2814	Major facilitator Superfamily
HEC78_RS20465	COG0477	Major facilitator Superfamily
HEC78_RS20470	COG1737	Transcriptional regulator
HEC78_RS20470	COG0837	glucose binding
HEC78_RS20475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEC78_RS20490	COG3964	amidohydrolase
HEC78_RS20495	COG2271	Major facilitator Superfamily
HEC78_RS20500	COG2105	PFAM AIG2 family protein
HEC78_RS20520	COG1253	flavin adenine dinucleotide binding
HEC78_RS20530	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HEC78_RS20545	COG1733	regulation of RNA biosynthetic process
HEC78_RS20550	COG0702	epimerase
HEC78_RS20555	COG0697	spore germination
HEC78_RS20565	COG1113	amino acid transport
HEC78_RS20570	COG0545	Peptidyl-prolyl cis-trans isomerase
HEC78_RS20575	COG3061	Opacity-associated protein A
HEC78_RS20590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEC78_RS20655	COG1073	alpha beta
HEC78_RS20660	COG3650	response to hydrogen peroxide
HEC78_RS20670	COG1960	acyl-CoA dehydrogenase activity
HEC78_RS20675	COG0754	glutathionylspermidine amidase activity
HEC78_RS20680	COG5463	Belongs to the UPF0441 family
HEC78_RS20685	COG3766	membrane
HEC78_RS20695	COG1842	Phage shock protein A
HEC78_RS20700	COG3789	protein conserved in bacteria
HEC78_RS20710	COG0557	exoribonuclease II activity
HEC78_RS20725	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HEC78_RS20730	COG0330	HflC and HflK could
HEC78_RS20735	COG0330	HflC and HflK could
HEC78_RS20740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEC78_RS20765	COG0802	atpase or kinase
HEC78_RS20770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEC78_RS20770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEC78_RS20790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC78_RS20810	COG1511	domain protein
HEC78_RS20810	COG3264	Mechanosensitive ion channel
HEC78_RS20830	COG1053	succinate dehydrogenase
HEC78_RS20835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEC78_RS20865	COG5510	response to toxic substance
HEC78_RS20905	COG0531	amino acid
HEC78_RS20910	COG3030	protein affecting phage T7 exclusion by the F plasmid
HEC78_RS20915	COG1027	Aspartate ammonia-lyase
HEC78_RS20920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC78_RS20935	COG1309	transcriptional regulator
HEC78_RS20950	COG0671	phosphoesterase, PA-phosphatase related
HEC78_RS20980	COG2197	response regulator
HEC78_RS21005	COG3381	protein complex oligomerization
HEC78_RS21010	COG3302	dmso reductase anchor subunit
HEC78_RS21015	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS21020	COG0243	molybdopterin cofactor binding
HEC78_RS21025	COG3290	protein histidine kinase activity
HEC78_RS21030	COG4565	transcriptional regulatory protein
HEC78_RS21040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC78_RS21045	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC78_RS21045	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC78_RS21060	COG2169	Transcriptional regulator
HEC78_RS21065	COG1982	Orn Lys Arg decarboxylase major
HEC78_RS21070	COG2207	Transcriptional regulator
HEC78_RS21075	COG0531	amino acid
HEC78_RS21105	COG2824	Alkylphosphonate utilization operon protein PhnA
HEC78_RS21110	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HEC78_RS21130	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HEC78_RS21140	COG1301	dicarboxylic acid transport
HEC78_RS21145	COG4235	cytochrome complex assembly
HEC78_RS21150	COG3088	subunit of a heme lyase
HEC78_RS21155	COG1138	Cytochrome C-type biogenesis protein
HEC78_RS21160	COG3301	Polysulphide reductase, NrfD
HEC78_RS21165	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS21170	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HEC78_RS21180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEC78_RS21185	COG3162	membrane
HEC78_RS21195	COG1346	cytolysis
HEC78_RS21200	COG1380	Effector of murein hydrolase LrgA
HEC78_RS21205	COG0583	DNA-binding transcription factor activity
HEC78_RS21210	COG0025	NhaP-type Na H and K H
HEC78_RS21215	COG2252	PERMEase
HEC78_RS21235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HEC78_RS21300	COG2315	Protein conserved in bacteria
HEC78_RS21310	COG3700	Belongs to the class B bacterial acid phosphatase family
HEC78_RS21350	COG0735	belongs to the Fur family
HEC78_RS21365	COG0534	Mate efflux family protein
HEC78_RS21375	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEC78_RS21420	COG3833	ABC-type maltose transport systems, permease component
HEC78_RS21430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC78_RS21455	COG0527	aspartate kinase activity
HEC78_RS21470	COG0561	phosphatase activity
HEC78_RS21475	COG1349	DNA-binding transcription factor activity
HEC78_RS21490	COG3122	Protein conserved in bacteria
HEC78_RS21535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEC78_RS21575	COG0151	Belongs to the GarS family
HEC78_RS21580	COG2204	response regulator
HEC78_RS21640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEC78_RS21645	COG2104	thiamine diphosphate biosynthetic process
HEC78_RS21705	COG0250	Participates in transcription elongation, termination and antitermination
HEC78_RS21755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEC78_RS21815	COG0583	DNA-binding transcription factor activity
HEC78_RS21855	COG2207	Transcriptional regulator
HEC78_RS21865	COG0371	Dehydrogenase
HEC78_RS21870	COG3738	Protein conserved in bacteria
HEC78_RS21890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEC78_RS21895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEC78_RS21900	COG0737	Belongs to the 5'-nucleotidase family
HEC78_RS21915	COG0668	transmembrane transport
HEC78_RS21920	COG0460	homoserine dehydrogenase
HEC78_RS21920	COG0527	aspartate kinase activity
HEC78_RS21925	COG0626	cystathionine gamma-synthase activity
HEC78_RS21950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEC78_RS21955	COG1609	Transcriptional regulator
HEC78_RS21960	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEC78_RS21975	COG1575	Belongs to the MenA family. Type 1 subfamily
HEC78_RS21990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEC78_RS22000	COG1494	fructose-1,6-bisphosphatase
HEC78_RS22010	COG3152	Membrane
HEC78_RS22030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEC78_RS22045	COG2211	Major facilitator Superfamily
HEC78_RS22070	COG3678	ATP-independent chaperone mediated protein folding
HEC78_RS22075	COG0745	RESPONSE REGULATOR receiver
HEC78_RS22080	COG2205	protein histidine kinase activity
HEC78_RS22090	COG2258	MOSC domain
HEC78_RS22105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HEC78_RS22150	COG1454	alcohol dehydrogenase
HEC78_RS22165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HEC78_RS22195	COG0437	4 iron, 4 sulfur cluster binding
HEC78_RS22200	COG2864	formate dehydrogenase
HEC78_RS22215	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HEC78_RS22225	COG4680	protein conserved in bacteria
HEC78_RS22230	COG5499	transcription regulator containing HTH domain
HEC78_RS22235	COG0456	acetyltransferase
HEC78_RS22250	COG1011	Hydrolase
HEC78_RS22255	COG1349	DNA-binding transcription factor activity
HEC78_RS22260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS22270	COG3684	Belongs to the aldolase LacD family
HEC78_RS22280	COG2017	converts alpha-aldose to the beta-anomer
HEC78_RS22285	COG1501	Belongs to the glycosyl hydrolase 31 family
HEC78_RS22330	COG0561	phosphatase activity
HEC78_RS22385	COG0204	Acyl-transferase
HEC78_RS22400	COG3084	Protein conserved in bacteria
HEC78_RS22410	COG1763	Mo-molybdopterin cofactor biosynthetic process
HEC78_RS22455	COG1739	Uncharacterized protein family UPF0029
HEC78_RS22485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEC78_RS22500	COG0805	protein transport
HEC78_RS22505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEC78_RS22545	COG0641	radical SAM
HEC78_RS22565	COG0561	phosphatase activity
HEC78_RS22570	COG2267	carboxylic ester hydrolase activity
HEC78_RS22575	COG1280	lysine exporter protein (LysE YggA)
HEC78_RS22580	COG1280	lysine exporter protein (LysE YggA)
HEC78_RS22625	COG1011	Hydrolase
HEC78_RS22630	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HEC78_RS22685	COG2959	enzyme of heme biosynthesis
HEC78_RS22690	COG3071	HemY protein
HEC78_RS22740	COG2244	polysaccharide biosynthetic process
HEC78_RS22745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEC78_RS22750	COG0456	acetyltransferase
HEC78_RS22755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEC78_RS22755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEC78_RS22760	COG1088	dTDP-glucose 4,6-dehydratase activity
HEC78_RS22765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEC78_RS22795	COG3118	belongs to the thioredoxin family
HEC78_RS22865	COG3978	acetolactate synthase activity
HEC78_RS22925	COG2186	Transcriptional regulator
HEC78_RS22930	COG0477	Major facilitator Superfamily
HEC78_RS22935	COG1609	Transcriptional regulator
HEC78_RS22940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC78_RS22950	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC78_RS22985	COG1522	sequence-specific DNA binding
HEC78_RS22990	COG0716	FMN binding
HEC78_RS23005	COG3312	ion transport
HEC78_RS23065	COG4533	DNA binding
HEC78_RS23070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEC78_RS23075	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HEC78_RS23075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC78_RS23075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC78_RS23080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEC78_RS23085	COG0573	inorganic phosphate transmembrane transporter activity
HEC78_RS23090	COG0581	inorganic phosphate transmembrane transporter activity
HEC78_RS23100	COG0704	Plays a role in the regulation of phosphate uptake
HEC78_RS23105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC78_RS23110	COG2252	PERMEase
HEC78_RS23115	COG0431	NADPH-dependent FMN reductase
HEC78_RS23120	COG2091	lysine biosynthetic process via aminoadipic acid
HEC78_RS23205	COG0210	DNA helicase
HEC78_RS23290	COG1192	Involved in chromosome partitioning
HEC78_RS23440	COG2890	protein-(glutamine-N5) methyltransferase activity
HEC78_RS23680	COG0697	spore germination
HEC78_RS23805	COG1695	Transcriptional regulator
HEC78_RS23830	COG3173	Aminoglycoside phosphotransferase
HEC78_RS23895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEC78_RS23965	COG3550	peptidyl-serine autophosphorylation
HEC78_RS24045	COG1358	cellular component organization or biogenesis
HEC78_RS24075	COG4245	von Willebrand factor, type A
HEC78_RS24080	COG4245	von Willebrand factor, type A