locus-tag	class	description
HFS01_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HFS01_RS00030	COG0561	phosphatase activity
HFS01_RS00050	COG2205	protein histidine kinase activity
HFS01_RS00050	COG2198	Histidine kinase
HFS01_RS00050	COG0784	Response regulator, receiver
HFS01_RS00055	COG1879	ABC-type sugar transport system periplasmic component
HFS01_RS00060	COG0745	RESPONSE REGULATOR receiver
HFS01_RS00065	COG3005	denitrification pathway
HFS01_RS00080	COG1858	cytochrome C peroxidase
HFS01_RS00090	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS01_RS00095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS01_RS00100	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS01_RS00110	COG1138	Cytochrome C-type biogenesis protein
HFS01_RS00115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFS01_RS00120	COG4235	cytochrome complex assembly
HFS01_RS00120	COG3088	subunit of a heme lyase
HFS01_RS00125	COG0823	Involved in the tonB-independent uptake of proteins
HFS01_RS00130	COG5645	(Lipo)protein
HFS01_RS00155	COG2149	membrane
HFS01_RS00165	COG0641	radical SAM
HFS01_RS00175	COG2610	gluconate transmembrane transporter activity
HFS01_RS00180	COG0583	DNA-binding transcription factor activity
HFS01_RS00190	COG2814	Major facilitator Superfamily
HFS01_RS00215	COG0028	Belongs to the TPP enzyme family
HFS01_RS00220	COG0440	acetolactate synthase activity
HFS01_RS00225	COG1349	DNA-binding transcription factor activity
HFS01_RS00235	COG0738	Major facilitator superfamily
HFS01_RS00270	COG2188	Transcriptional regulator
HFS01_RS00275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS00275	COG3711	transcriptional antiterminator
HFS01_RS00280	COG3414	Phosphotransferase system galactitol-specific IIB component
HFS01_RS00285	COG3775	system Galactitol-specific IIC component
HFS01_RS00325	COG2723	6-phospho-beta-galactosidase activity
HFS01_RS00345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS01_RS00345	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS00350	COG3715	PTS system
HFS01_RS00355	COG3716	PTS system mannose fructose sorbose family IID component
HFS01_RS00370	COG5464	transposase or invertase
HFS01_RS00380	COG1285	pathogenesis
HFS01_RS00400	COG1335	isochorismatase
HFS01_RS00410	COG3710	Transcriptional regulator
HFS01_RS00425	COG2771	luxR family
HFS01_RS00460	COG2211	Major facilitator Superfamily
HFS01_RS00465	COG1501	Belongs to the glycosyl hydrolase 31 family
HFS01_RS00470	COG2982	Protein involved in outer membrane biogenesis
HFS01_RS00475	COG2233	PERMEase
HFS01_RS00480	COG0786	glutamate:sodium symporter activity
HFS01_RS00485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFS01_RS00490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFS01_RS00495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFS01_RS00515	COG2860	membrane
HFS01_RS00525	COG0583	DNA-binding transcription factor activity
HFS01_RS00530	COG1561	YicC-like family, N-terminal region
HFS01_RS00555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFS01_RS00585	COG1519	Transferase
HFS01_RS00590	COG0859	PFAM glycosyl transferase family 9
HFS01_RS00595	COG0438	transferase activity, transferring glycosyl groups
HFS01_RS00670	COG1216	Glycosyl transferase, family 2
HFS01_RS00675	COG2861	carbohydrate metabolic process
HFS01_RS00680	COG4942	peptidase
HFS01_RS00690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFS01_RS00695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HFS01_RS00715	COG2271	Major facilitator Superfamily
HFS01_RS00725	COG1609	Transcriptional regulator
HFS01_RS00730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFS01_RS00740	COG2186	Transcriptional regulator
HFS01_RS00770	COG3722	fumarate hydratase activity
HFS01_RS00780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS00780	COG2213	PTS system mannitol-specific
HFS01_RS00785	COG0625	glutathione transferase activity
HFS01_RS00795	COG3276	selenocysteine insertion sequence binding
HFS01_RS00800	COG1940	carbohydrate kinase activity
HFS01_RS00805	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS00815	COG0235	Class ii aldolase
HFS01_RS00820	COG3623	hexulose-6-phosphate isomerase
HFS01_RS00825	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HFS01_RS00830	COG1070	Carbohydrate kinase
HFS01_RS00835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFS01_RS00840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HFS01_RS00845	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HFS01_RS00855	COG2731	YhcH YjgK YiaL family protein
HFS01_RS00865	COG1414	Transcriptional regulator
HFS01_RS00870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS01_RS00875	COG3977	Valine--pyruvate aminotransferase
HFS01_RS00880	COG0366	Alpha amylase catalytic
HFS01_RS00885	COG2992	FlgJ-related protein
HFS01_RS00890	COG1609	Transcriptional regulator
HFS01_RS00890	COG2207	Transcriptional regulator
HFS01_RS00900	COG1070	Carbohydrate kinase
HFS01_RS00905	COG4682	membrane
HFS01_RS00910	COG3274	enterobacterial common antigen metabolic process
HFS01_RS00930	COG2801	Transposase and inactivated derivatives
HFS01_RS00960	COG1278	Cold shock
HFS01_RS00965	COG2944	sequence-specific DNA binding
HFS01_RS00980	COG2885	chlorophyll binding
HFS01_RS00985	COG0243	molybdopterin cofactor binding
HFS01_RS00990	COG0456	acetyltransferase
HFS01_RS00995	COG2818	Glycosylase
HFS01_RS01000	COG5571	outer membrane autotransporter
HFS01_RS01005	COG3039	Transposase
HFS01_RS01065	COG0747	negative chemotaxis
HFS01_RS01070	COG0601	transmembrane transport
HFS01_RS01075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFS01_RS01080	COG0444	Belongs to the ABC transporter superfamily
HFS01_RS01085	COG4608	Belongs to the ABC transporter superfamily
HFS01_RS01090	COG0814	amino acid
HFS01_RS01150	COG2200	EAL domain
HFS01_RS01150	COG2199	diguanylate cyclase activity
HFS01_RS01165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS01170	COG2200	EAL domain
HFS01_RS01175	COG2982	Protein involved in outer membrane biogenesis
HFS01_RS01180	COG0477	Major facilitator Superfamily
HFS01_RS01185	COG1295	ribonuclease BN
HFS01_RS01190	COG0583	DNA-binding transcription factor activity
HFS01_RS01195	COG2197	response regulator
HFS01_RS01215	COG2188	Transcriptional regulator
HFS01_RS01220	COG2222	sugar isomerase
HFS01_RS01225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS01230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HFS01_RS01240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS01250	COG1082	Xylose isomerase domain protein TIM barrel
HFS01_RS01255	COG2814	Major facilitator Superfamily
HFS01_RS01260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFS01_RS01265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HFS01_RS01305	COG0306	phosphate transporter
HFS01_RS01310	COG2081	HI0933 family
HFS01_RS01315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS01_RS01320	COG0842	Transport permease protein
HFS01_RS01320	COG1129	ABC transporter
HFS01_RS01325	COG0842	Transport permease protein
HFS01_RS01340	COG0628	permease
HFS01_RS01355	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HFS01_RS01375	COG3714	YhhN family
HFS01_RS01385	COG3776	membrane
HFS01_RS01390	COG0742	ribosomal rna small subunit methyltransferase
HFS01_RS01395	COG0552	protein localization to endoplasmic reticulum
HFS01_RS01400	COG2884	Cell division ATP-binding protein ftsE
HFS01_RS01405	COG2177	Part of the ABC transporter FtsEX involved in
HFS01_RS01480	COG0584	glycerophosphoryl diester phosphodiesterase
HFS01_RS01490	COG0405	Gamma-glutamyltransferase
HFS01_RS01495	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HFS01_RS01510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS01515	COG1247	-acetyltransferase
HFS01_RS01520	COG0673	inositol 2-dehydrogenase activity
HFS01_RS01525	COG1741	Belongs to the pirin family
HFS01_RS01530	COG1609	Transcriptional regulator
HFS01_RS01535	COG3265	gluconokinase activity
HFS01_RS01540	COG2610	gluconate transmembrane transporter activity
HFS01_RS01555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HFS01_RS01575	COG0058	SHG alpha-glucan phosphorylase activity
HFS01_RS01580	COG1414	Transcriptional regulator
HFS01_RS01585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFS01_RS01590	COG0129	dihydroxy-acid dehydratase activity
HFS01_RS01600	COG0371	Dehydrogenase
HFS01_RS01615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HFS01_RS01630	COG1349	DNA-binding transcription factor activity
HFS01_RS01635	COG4650	regulator
HFS01_RS01645	COG1690	Belongs to the RtcB family
HFS01_RS01665	COG0058	SHG alpha-glucan phosphorylase activity
HFS01_RS01670	COG1640	4-alpha-glucanotransferase
HFS01_RS01675	COG2610	gluconate transmembrane transporter activity
HFS01_RS01695	COG5464	transposase or invertase
HFS01_RS01710	COG1918	ferrous iron import across plasma membrane
HFS01_RS01715	COG2183	response to ionizing radiation
HFS01_RS01720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFS01_RS01740	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HFS01_RS01750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HFS01_RS01755	COG1011	Hydrolase
HFS01_RS01765	COG0494	nUDIX hydrolase
HFS01_RS01770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HFS01_RS01775	COG4972	Pilus assembly protein
HFS01_RS01780	COG3166	PFAM Fimbrial assembly family protein
HFS01_RS01795	COG4796	Type ii and iii secretion system protein
HFS01_RS01810	COG3266	domain, Protein
HFS01_RS01815	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HFS01_RS01820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFS01_RS01860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFS01_RS01895	COG1289	transmembrane transporter activity
HFS01_RS01905	COG1765	OsmC-like protein
HFS01_RS01910	COG3954	Phosphoribulokinase
HFS01_RS01920	COG0429	hydrolase of the alpha beta-hydrolase fold
HFS01_RS01935	COG0488	(ABC) transporter
HFS01_RS01950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HFS01_RS01955	COG1047	Peptidyl-prolyl cis-trans
HFS01_RS01965	COG0545	Peptidyl-prolyl cis-trans isomerase
HFS01_RS01970	COG2964	Protein conserved in bacteria
HFS01_RS02025	COG0051	transcription antitermination factor activity, RNA binding
HFS01_RS02050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HFS01_RS02130	COG0201	protein transport
HFS01_RS02170	COG0789	Transcriptional regulator
HFS01_RS02175	COG3036	rescue of stalled ribosome
HFS01_RS02205	COG0758	DNA mediated transformation
HFS01_RS02215	COG0551	DNA topoisomerase type I activity
HFS01_RS02235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFS01_RS02280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFS01_RS02285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS01_RS02290	COG1309	transcriptional regulator
HFS01_RS02305	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HFS01_RS02330	COG4145	pantothenate transmembrane transporter activity
HFS01_RS02335	COG3924	membrane
HFS01_RS02340	COG0439	Biotin carboxylase
HFS01_RS02345	COG0511	ligase activity, forming carbon-carbon bonds
HFS01_RS02360	COG0604	alcohol dehydrogenase
HFS01_RS02365	COG2199	diguanylate cyclase activity
HFS01_RS02365	COG2200	EAL domain
HFS01_RS02370	COG1077	Cell shape determining protein MreB Mrl
HFS01_RS02375	COG1792	Involved in formation and maintenance of cell shape
HFS01_RS02380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HFS01_RS02395	COG3164	Protein of unknown function
HFS01_RS02400	COG0312	modulator of DNA gyrase
HFS01_RS02405	COG0583	DNA-binding transcription factor activity
HFS01_RS02425	COG2732	(Barnase) inhibitor
HFS01_RS02450	COG2188	Transcriptional regulator
HFS01_RS02460	COG0471	metal ion transport
HFS01_RS02465	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS01_RS02470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS01_RS02475	COG3630	sodium ion export across plasma membrane
HFS01_RS02485	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HFS01_RS02500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFS01_RS02505	COG3105	Protein conserved in bacteria
HFS01_RS02510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HFS01_RS02530	COG0625	glutathione transferase activity
HFS01_RS02535	COG2969	positive regulation of protein catabolic process
HFS01_RS02565	COG2731	YhcH YjgK YiaL family protein
HFS01_RS02570	COG0402	S-adenosylhomocysteine deaminase activity
HFS01_RS02580	COG4804	nuclease activity
HFS01_RS02585	COG0493	'glutamate synthase
HFS01_RS02590	COG0069	glutamate synthase activity
HFS01_RS02590	COG0067	glutamate synthase
HFS01_RS02590	COG0070	glutamate synthase
HFS01_RS02595	COG1242	4 iron, 4 sulfur cluster binding
HFS01_RS02600	COG5002	protein histidine kinase activity
HFS01_RS02600	COG2198	Histidine kinase
HFS01_RS02600	COG0784	Response regulator, receiver
HFS01_RS02605	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HFS01_RS02615	COG0515	serine threonine protein kinase
HFS01_RS02620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS02645	COG1137	ATPase activity
HFS01_RS02650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HFS01_RS02655	COG3117	lipopolysaccharide transmembrane transporter activity
HFS01_RS02660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HFS01_RS02670	COG0530	calcium, potassium:sodium antiporter activity
HFS01_RS02675	COG1127	ABC transporter
HFS01_RS02680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFS01_RS02685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFS01_RS02690	COG2854	intermembrane phospholipid transfer
HFS01_RS02695	COG3113	response to antibiotic
HFS01_RS02700	COG5007	Belongs to the BolA IbaG family
HFS01_RS02710	COG3423	Transcriptional regulator
HFS01_RS02715	COG0142	geranyltranstransferase activity
HFS01_RS02730	COG0697	spore germination
HFS01_RS02740	COG2027	D-alanyl-D-alanine carboxypeptidase
HFS01_RS02750	COG1534	Rna-binding protein
HFS01_RS02765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFS01_RS02775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HFS01_RS02845	COG0513	Belongs to the DEAD box helicase family
HFS01_RS02850	COG0814	amino acid
HFS01_RS02855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFS01_RS02860	COG0826	peptidase U32
HFS01_RS02865	COG0826	peptidase U32
HFS01_RS02870	COG3154	lipid carrier protein
HFS01_RS02875	COG3153	acetyltransferase
HFS01_RS02890	COG0693	protein deglycase activity
HFS01_RS02895	COG0702	epimerase
HFS01_RS02900	COG2823	Periplasmic or secreted lipoprotein
HFS01_RS02915	COG3107	peptidoglycan biosynthetic process
HFS01_RS02920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HFS01_RS02930	COG1063	alcohol dehydrogenase
HFS01_RS02935	COG3775	system Galactitol-specific IIC component
HFS01_RS02940	COG3414	Phosphotransferase system galactitol-specific IIB component
HFS01_RS02945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS02960	COG2721	sulfolactate sulfo-lyase activity
HFS01_RS02970	COG2084	Dehydrogenase
HFS01_RS02975	COG1929	Belongs to the glycerate kinase type-1 family
HFS01_RS02985	COG0583	DNA-binding transcription factor activity
HFS01_RS03005	COG1882	Formate acetyltransferase
HFS01_RS03010	COG1760	l-serine dehydratase
HFS01_RS03015	COG0814	amino acid
HFS01_RS03030	COG1741	Belongs to the pirin family
HFS01_RS03035	COG0583	DNA-binding transcription factor activity
HFS01_RS03040	COG3152	Membrane
HFS01_RS03045	COG0435	Glutathione S-transferase
HFS01_RS03050	COG2259	Doxx family
HFS01_RS03060	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HFS01_RS03065	COG4575	ribosome binding
HFS01_RS03070	COG1422	Protein of unknown function (DUF1090)
HFS01_RS03080	COG0586	Pfam SNARE associated Golgi protein
HFS01_RS03095	COG0673	inositol 2-dehydrogenase activity
HFS01_RS03100	COG2949	membrane
HFS01_RS03105	COG1451	nucleotide metabolic process
HFS01_RS03115	COG1902	pentaerythritol trinitrate reductase activity
HFS01_RS03115	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFS01_RS03125	COG0840	transmembrane signaling receptor activity
HFS01_RS03130	COG0840	transmembrane signaling receptor activity
HFS01_RS03135	COG1695	Transcriptional regulator
HFS01_RS03140	COG2375	cellular response to nickel ion
HFS01_RS03235	COG4626	Terminase
HFS01_RS03235	COG1802	Transcriptional regulator
HFS01_RS03360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HFS01_RS03365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFS01_RS03385	COG3468	outer membrane autotransporter barrel domain protein
HFS01_RS03415	COG2894	cell division
HFS01_RS03430	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HFS01_RS03455	COG0412	Dienelactone hydrolase
HFS01_RS03460	COG2186	Transcriptional regulator
HFS01_RS03480	COG0583	DNA-binding transcription factor activity
HFS01_RS03485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFS01_RS03490	COG0700	Nucleoside recognition
HFS01_RS03495	COG3366	ferrous iron transmembrane transporter activity
HFS01_RS03500	COG0477	Major facilitator Superfamily
HFS01_RS03505	COG2733	membrane
HFS01_RS03515	COG5464	transposase or invertase
HFS01_RS03520	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS03535	COG3586	endonuclease activity
HFS01_RS03540	COG1280	lysine exporter protein (LysE YggA)
HFS01_RS03550	COG0523	cobalamin synthesis protein
HFS01_RS03555	COG2879	small protein
HFS01_RS03560	COG1966	Carbon starvation protein
HFS01_RS03565	COG0840	transmembrane signaling receptor activity
HFS01_RS03580	COG1484	DNA-dependent DNA replication
HFS01_RS03595	COG2966	Psort location CytoplasmicMembrane, score
HFS01_RS03600	COG2197	response regulator
HFS01_RS03605	COG2197	response regulator
HFS01_RS03610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFS01_RS03615	COG4114	ferric iron reductase
HFS01_RS03620	COG3706	GGDEF domain
HFS01_RS03650	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HFS01_RS03660	COG1011	Hydrolase
HFS01_RS03670	COG2823	Periplasmic or secreted lipoprotein
HFS01_RS03680	COG4667	esterase of the alpha-beta hydrolase superfamily
HFS01_RS03685	COG0084	hydrolase, TatD family'
HFS01_RS03690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFS01_RS03695	COG1328	CTP reductase activity
HFS01_RS03725	COG3188	usher protein
HFS01_RS03730	COG3121	Chaperone
HFS01_RS03735	COG3539	Fimbrial protein
HFS01_RS03750	COG3726	membrane protein affecting hemolysin expression
HFS01_RS03755	COG0560	Phosphoserine phosphatase
HFS01_RS03770	COG0488	(ABC) transporter
HFS01_RS03795	COG3708	Transcriptional regulator
HFS01_RS03795	COG2207	Transcriptional regulator
HFS01_RS03800	COG3045	CreA protein
HFS01_RS03805	COG0745	RESPONSE REGULATOR receiver
HFS01_RS03810	COG2205	protein histidine kinase activity
HFS01_RS03815	COG4452	Inner membrane protein CreD
HFS01_RS03835	COG3121	Chaperone
HFS01_RS03855	COG0745	RESPONSE REGULATOR receiver
HFS01_RS03865	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HFS01_RS03875	COG0527	aspartate kinase activity
HFS01_RS03875	COG0460	homoserine dehydrogenase
HFS01_RS03885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HFS01_RS03895	COG1115	amino acid carrier protein
HFS01_RS03905	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFS01_RS03910	COG1584	GPR1 FUN34 yaaH family protein
HFS01_RS03915	COG4735	regulation of single-species biofilm formation
HFS01_RS03980	COG3188	usher protein
HFS01_RS03995	COG3539	Fimbrial protein
HFS01_RS04000	COG3121	Chaperone
HFS01_RS04020	COG0583	DNA-binding transcription factor activity
HFS01_RS04035	COG0737	Belongs to the 5'-nucleotidase family
HFS01_RS04045	COG3119	arylsulfatase activity
HFS01_RS04050	COG0641	radical SAM
HFS01_RS04070	COG0583	DNA-binding transcription factor activity
HFS01_RS04095	COG0196	riboflavin kinase activity
HFS01_RS04110	COG1047	Peptidyl-prolyl cis-trans
HFS01_RS04145	COG0511	ligase activity, forming carbon-carbon bonds
HFS01_RS04145	COG5016	pyruvate
HFS01_RS04230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFS01_RS04255	COG0644	oxidoreductase
HFS01_RS04265	COG2271	Major facilitator Superfamily
HFS01_RS04285	COG3119	arylsulfatase activity
HFS01_RS04320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HFS01_RS04350	COG0417	DNA replication proofreading
HFS01_RS04390	COG0586	Pfam SNARE associated Golgi protein
HFS01_RS04480	COG0768	penicillin binding
HFS01_RS04490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFS01_RS04505	COG0772	Belongs to the SEDS family
HFS01_RS04530	COG0849	cell division
HFS01_RS04535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFS01_RS04555	COG0494	nUDIX hydrolase
HFS01_RS04560	COG0667	Aldo Keto reductase
HFS01_RS04565	COG0583	DNA-binding transcription factor activity
HFS01_RS04590	COG1459	type II secretion system
HFS01_RS04595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HFS01_RS04600	COG4969	Belongs to the N-Me-Phe pilin family
HFS01_RS04615	COG3725	Membrane protein required for beta-lactamase induction
HFS01_RS04620	COG3940	Belongs to the glycosyl hydrolase 43 family
HFS01_RS04625	COG2211	Major facilitator Superfamily
HFS01_RS04640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HFS01_RS04645	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFS01_RS04650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFS01_RS04665	COG3064	Membrane
HFS01_RS04735	COG1349	DNA-binding transcription factor activity
HFS01_RS04755	COG2132	Multicopper oxidase
HFS01_RS04760	COG4993	Dehydrogenase
HFS01_RS04770	COG0288	reversible hydration of carbon dioxide
HFS01_RS04775	COG1131	(ABC) transporter
HFS01_RS04780	COG0842	Transport permease protein
HFS01_RS04785	COG3539	Fimbrial protein
HFS01_RS04805	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS04810	COG0726	polysaccharide deacetylase
HFS01_RS04830	COG3539	Fimbrial protein
HFS01_RS04835	COG3188	usher protein
HFS01_RS04840	COG3121	Chaperone
HFS01_RS04865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFS01_RS04870	COG0617	tRNA 3'-terminal CCA addition
HFS01_RS04890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HFS01_RS04895	COG1643	Atp-dependent helicase
HFS01_RS04900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFS01_RS04905	COG4774	siderophore transport
HFS01_RS04910	COG1120	ATPase activity
HFS01_RS04915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFS01_RS04930	COG3188	usher protein
HFS01_RS04935	COG3121	Chaperone
HFS01_RS04940	COG3539	Fimbrial protein
HFS01_RS04945	COG3539	Fimbrial protein
HFS01_RS04975	COG2860	membrane
HFS01_RS05000	COG3835	regulator
HFS01_RS05010	COG0477	Major facilitator Superfamily
HFS01_RS05060	COG0575	Belongs to the CDS family
HFS01_RS05120	COG1982	Orn Lys Arg decarboxylase major
HFS01_RS05125	COG0346	lactoylglutathione lyase activity
HFS01_RS05135	COG4568	rho-dependent transcription termination
HFS01_RS05150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HFS01_RS05155	COG3015	lipoprotein NlpE involved in copper resistance
HFS01_RS05165	COG1720	tRNA m6t6A37 methyltransferase activity
HFS01_RS05190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HFS01_RS05225	COG0656	L-ascorbic acid biosynthetic process
HFS01_RS05230	COG0583	DNA-binding transcription factor activity
HFS01_RS05235	COG2814	Major facilitator Superfamily
HFS01_RS05245	COG2226	methyltransferase
HFS01_RS05250	COG1388	LysM domain
HFS01_RS05250	COG0741	lytic transglycosylase activity
HFS01_RS05260	COG2226	methyltransferase
HFS01_RS05370	COG3047	cAMP biosynthetic process
HFS01_RS05370	COG2885	chlorophyll binding
HFS01_RS05440	COG3209	COG3209 Rhs family protein
HFS01_RS05460	COG3209	COG3209 Rhs family protein
HFS01_RS05470	COG3209	COG3209 Rhs family protein
HFS01_RS05500	COG3209	COG3209 Rhs family protein
HFS01_RS05615	COG1522	sequence-specific DNA binding
HFS01_RS05645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFS01_RS05660	COG0121	glutamine amidotransferase
HFS01_RS05665	COG3034	peptidoglycan biosynthetic process
HFS01_RS05675	COG1690	Belongs to the RtcB family
HFS01_RS05680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HFS01_RS05685	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFS01_RS05740	COG3188	usher protein
HFS01_RS05745	COG3121	Chaperone
HFS01_RS05750	COG3539	Fimbrial protein
HFS01_RS05765	COG2200	EAL domain
HFS01_RS05820	COG0789	Transcriptional regulator
HFS01_RS05830	COG2814	Major facilitator Superfamily
HFS01_RS05850	COG1271	oxidase subunit
HFS01_RS05855	COG1294	oxidase, subunit
HFS01_RS05875	COG1280	lysine exporter protein (LysE YggA)
HFS01_RS05910	COG0113	porphobilinogen synthase activity
HFS01_RS05925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HFS01_RS05930	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HFS01_RS05975	COG3706	GGDEF domain
HFS01_RS05980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFS01_RS06000	COG4126	flavin adenine dinucleotide binding
HFS01_RS06015	COG1940	carbohydrate kinase activity
HFS01_RS06020	COG2814	Major facilitator Superfamily
HFS01_RS06025	COG0419	ATPase involved in DNA repair
HFS01_RS06030	COG0420	3'-5' exonuclease activity
HFS01_RS06040	COG5002	protein histidine kinase activity
HFS01_RS06055	COG0366	Alpha amylase catalytic
HFS01_RS06060	COG0450	alkyl hydroperoxide reductase
HFS01_RS06080	COG1862	Preprotein translocase
HFS01_RS06090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFS01_RS06120	COG4238	major outer membrane lipoprotein
HFS01_RS06130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFS01_RS06130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFS01_RS06145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HFS01_RS06150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HFS01_RS06155	COG0667	Aldo Keto reductase
HFS01_RS06165	COG0142	geranyltranstransferase activity
HFS01_RS06200	COG2188	Transcriptional regulator
HFS01_RS06230	COG2814	Major facilitator Superfamily
HFS01_RS06250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HFS01_RS06255	COG1845	cytochrome c oxidase, subunit III
HFS01_RS06260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFS01_RS06265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFS01_RS06270	COG2223	nitrite transmembrane transporter activity
HFS01_RS06275	COG3056	Lipoprotein
HFS01_RS06280	COG0271	Belongs to the BolA IbaG family
HFS01_RS06300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HFS01_RS06310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFS01_RS06315	COG1555	photosystem II stabilization
HFS01_RS06320	COG0824	Thioesterase
HFS01_RS06330	COG4533	DNA binding
HFS01_RS06335	COG0561	phosphatase activity
HFS01_RS06345	COG1522	sequence-specific DNA binding
HFS01_RS06350	COG1132	(ABC) transporter
HFS01_RS06355	COG1132	(ABC) transporter
HFS01_RS06360	COG0347	Belongs to the P(II) protein family
HFS01_RS06365	COG0004	ammonium transporteR
HFS01_RS06370	COG1946	Acyl-CoA thioesterase
HFS01_RS06375	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HFS01_RS06380	COG3695	enzyme binding
HFS01_RS06390	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HFS01_RS06410	COG0110	maltose O-acetyltransferase activity
HFS01_RS06425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFS01_RS06430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS01_RS06435	COG1309	transcriptional regulator
HFS01_RS06440	COG1196	nuclear chromosome segregation
HFS01_RS06440	COG3264	Mechanosensitive ion channel
HFS01_RS06445	COG5464	transposase or invertase
HFS01_RS06455	COG3923	Primosomal replication protein n
HFS01_RS06460	COG2832	Protein of unknown function (DUF454)
HFS01_RS06505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS06510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFS01_RS06510	COG4651	solute:proton antiporter activity
HFS01_RS06515	COG2223	nitrite transmembrane transporter activity
HFS01_RS06530	COG3735	TraB family
HFS01_RS06540	COG2217	Heavy metal translocating P-type atpase
HFS01_RS06550	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFS01_RS06555	COG0330	HflC and HflK could
HFS01_RS06560	COG4619	ABC transporter
HFS01_RS06565	COG0390	transport system, permease component
HFS01_RS06570	COG3118	belongs to the thioredoxin family
HFS01_RS06575	COG0300	oxidoreductase activity
HFS01_RS06580	COG2755	lipolytic protein G-D-S-L family
HFS01_RS06585	COG4181	ATPase activity
HFS01_RS06590	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HFS01_RS06600	COG1464	Belongs to the NlpA lipoprotein family
HFS01_RS06635	COG3960	tartronate-semialdehyde synthase activity
HFS01_RS06640	COG3622	Belongs to the hyi family
HFS01_RS06645	COG2084	Dehydrogenase
HFS01_RS06655	COG1953	Uracil, thiamine, allantoin
HFS01_RS06665	COG2233	PERMEase
HFS01_RS06670	COG1929	Belongs to the glycerate kinase type-1 family
HFS01_RS06675	COG3257	ureidoglycine aminohydrolase activity
HFS01_RS06680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFS01_RS06685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HFS01_RS06690	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFS01_RS06695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFS01_RS06705	COG0549	Belongs to the carbamate kinase family
HFS01_RS06710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFS01_RS06715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HFS01_RS06725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFS01_RS06745	COG1988	membrane-bound metal-dependent
HFS01_RS06750	COG2501	S4 domain
HFS01_RS06830	COG2246	polysaccharide biosynthetic process
HFS01_RS06855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFS01_RS06865	COG3059	membrane
HFS01_RS06875	COG1113	amino acid transport
HFS01_RS06880	COG0668	transmembrane transport
HFS01_RS06890	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HFS01_RS06890	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HFS01_RS06895	COG2222	sugar isomerase
HFS01_RS06905	COG3716	PTS system mannose fructose sorbose family IID component
HFS01_RS06930	COG2315	Protein conserved in bacteria
HFS01_RS06955	COG2977	Belongs to the P-Pant transferase superfamily
HFS01_RS06960	COG4771	TonB-dependent receptor
HFS01_RS06965	COG2382	esterase
HFS01_RS06970	COG3251	PFAM MbtH domain protein
HFS01_RS06975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFS01_RS06975	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HFS01_RS06980	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HFS01_RS06985	COG1120	ATPase activity
HFS01_RS06990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFS01_RS06995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFS01_RS07005	COG4592	Periplasmic binding protein
HFS01_RS07010	COG1169	isochorismate synthase
HFS01_RS07015	COG1021	2,3-dihydroxybenzoate-AMP ligase
HFS01_RS07020	COG1535	isochorismatase
HFS01_RS07020	COG3433	isochorismatase activity
HFS01_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS07035	COG1966	Carbon starvation protein
HFS01_RS07040	COG2879	small protein
HFS01_RS07045	COG0371	Dehydrogenase
HFS01_RS07050	COG0436	Aminotransferase
HFS01_RS07055	COG1475	DNA binding
HFS01_RS07060	COG3969	phosphoadenosine phosphosulfate
HFS01_RS07065	COG0583	DNA-binding transcription factor activity
HFS01_RS07070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFS01_RS07090	COG0243	molybdopterin cofactor binding
HFS01_RS07110	COG1063	alcohol dehydrogenase
HFS01_RS07115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFS01_RS07120	COG3719	Belongs to the RNase T2 family
HFS01_RS07125	COG0471	metal ion transport
HFS01_RS07140	COG3051	citrate lyase alpha subunit
HFS01_RS07145	COG2301	Belongs to the HpcH HpaI aldolase family
HFS01_RS07155	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HFS01_RS07160	COG3290	protein histidine kinase activity
HFS01_RS07165	COG4565	transcriptional regulatory protein
HFS01_RS07170	COG3069	C4-dicarboxylate transmembrane transporter activity
HFS01_RS07190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFS01_RS07205	COG0583	DNA-binding transcription factor activity
HFS01_RS07220	COG1686	Belongs to the peptidase S11 family
HFS01_RS07230	COG0772	Belongs to the SEDS family
HFS01_RS07235	COG0768	penicillin binding
HFS01_RS07245	COG0799	negative regulation of ribosome biogenesis
HFS01_RS07255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFS01_RS07265	COG1466	dna polymerase III delta subunit
HFS01_RS07295	COG3290	protein histidine kinase activity
HFS01_RS07295	COG3829	transcription factor binding
HFS01_RS07300	COG2888	peptidyl-tyrosine sulfation
HFS01_RS07315	COG2214	Heat shock protein DnaJ domain protein
HFS01_RS07325	COG2214	Heat shock protein DnaJ domain protein
HFS01_RS07330	COG0443	Heat shock 70 kDa protein
HFS01_RS07345	COG1126	abc transporter atp-binding protein
HFS01_RS07350	COG0765	amino acid transport
HFS01_RS07355	COG0765	amino acid transport
HFS01_RS07380	COG1702	phosphate starvation-inducible protein PhoH
HFS01_RS07390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFS01_RS07435	COG0367	asparagine synthase
HFS01_RS07440	COG0647	UMP catabolic process
HFS01_RS07445	COG1846	Transcriptional regulator
HFS01_RS07445	COG1940	carbohydrate kinase activity
HFS01_RS07450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFS01_RS07490	COG1053	succinate dehydrogenase
HFS01_RS07495	COG0583	DNA-binding transcription factor activity
HFS01_RS07500	COG0735	belongs to the Fur family
HFS01_RS07520	COG0596	Alpha beta hydrolase
HFS01_RS07530	COG0033	Phosphoglucomutase
HFS01_RS07540	COG0531	amino acid
HFS01_RS07545	COG1982	Orn Lys Arg decarboxylase major
HFS01_RS07555	COG0745	RESPONSE REGULATOR receiver
HFS01_RS07560	COG2205	protein histidine kinase activity
HFS01_RS07605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HFS01_RS07610	COG1984	allophanate hydrolase subunit 2
HFS01_RS07625	COG0582	viral genome integration into host DNA
HFS01_RS07665	COG1216	Glycosyl transferase, family 2
HFS01_RS07690	COG3180	Ammonia monooxygenase
HFS01_RS07710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HFS01_RS07725	COG0567	Dehydrogenase, E1 component
HFS01_RS07730	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFS01_RS07740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFS01_RS07745	COG1271	oxidase subunit
HFS01_RS07750	COG1294	oxidase, subunit
HFS01_RS07755	COG4890	Cyd operon protein YbgT
HFS01_RS07760	COG3790	cyd operon protein YbgE
HFS01_RS07765	COG0824	Thioesterase
HFS01_RS07770	COG0811	peptide transport
HFS01_RS07775	COG0848	biopolymer transport protein
HFS01_RS07780	COG3064	Membrane
HFS01_RS07790	COG2885	chlorophyll binding
HFS01_RS07795	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HFS01_RS07845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFS01_RS07850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFS01_RS07855	COG1120	ATPase activity
HFS01_RS07865	COG2017	converts alpha-aldose to the beta-anomer
HFS01_RS07890	COG1119	ATPase activity
HFS01_RS07895	COG2005	Transcriptional regulator
HFS01_RS07895	COG3585	molybdate ion transport
HFS01_RS07905	COG0725	ABC transporter, periplasmic molybdate-binding protein
HFS01_RS07910	COG4149	molybdate abc transporter
HFS01_RS07920	COG0561	phosphatase activity
HFS01_RS07930	COG4677	pectinesterase activity
HFS01_RS07960	COG1881	PFAM PEBP family protein
HFS01_RS08010	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFS01_RS08020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HFS01_RS08030	COG0670	Belongs to the BI1 family
HFS01_RS08050	COG0392	lysyltransferase activity
HFS01_RS08055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFS01_RS08060	COG3568	Endonuclease Exonuclease Phosphatase
HFS01_RS08070	COG0842	Transport permease protein
HFS01_RS08075	COG0842	Transport permease protein
HFS01_RS08080	COG1131	(ABC) transporter
HFS01_RS08090	COG1309	transcriptional regulator
HFS01_RS08095	COG0583	DNA-binding transcription factor activity
HFS01_RS08100	COG2271	Major facilitator Superfamily
HFS01_RS08105	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS08110	COG3959	Transketolase, thiamine diphosphate binding domain
HFS01_RS08115	COG3958	Transketolase
HFS01_RS08120	COG1454	alcohol dehydrogenase
HFS01_RS08120	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS08125	COG0513	Belongs to the DEAD box helicase family
HFS01_RS08135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFS01_RS08145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFS01_RS08155	COG0668	transmembrane transport
HFS01_RS08160	COG1126	abc transporter atp-binding protein
HFS01_RS08165	COG0765	amino acid transport
HFS01_RS08170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS01_RS08185	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HFS01_RS08190	COG2194	sulfuric ester hydrolase activity
HFS01_RS08205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFS01_RS08210	COG1376	ErfK ybiS ycfS ynhG family protein
HFS01_RS08215	COG0488	(ABC) transporter
HFS01_RS08235	COG0561	phosphatase activity
HFS01_RS08240	COG1882	Formate acetyltransferase
HFS01_RS08245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFS01_RS08295	COG2133	pyrroloquinoline quinone binding
HFS01_RS08300	COG0625	glutathione transferase activity
HFS01_RS08305	COG1686	Belongs to the peptidase S11 family
HFS01_RS08310	COG1349	DNA-binding transcription factor activity
HFS01_RS08315	COG0671	phosphoesterase, PA-phosphatase related
HFS01_RS08320	COG2814	Major facilitator Superfamily
HFS01_RS08325	COG0561	phosphatase activity
HFS01_RS08330	COG0738	Major facilitator superfamily
HFS01_RS08335	COG3226	Transcriptional regulator
HFS01_RS08375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HFS01_RS08380	COG3842	ATPase activity
HFS01_RS08385	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFS01_RS08390	COG1177	transmembrane transport
HFS01_RS08420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS01_RS08425	COG4160	amino acid transport
HFS01_RS08430	COG4215	(ABC) transporter
HFS01_RS08435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS01_RS08440	COG1126	abc transporter atp-binding protein
HFS01_RS08455	COG3023	N-Acetylmuramoyl-L-alanine amidase
HFS01_RS08460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFS01_RS08465	COG0702	epimerase
HFS01_RS08470	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HFS01_RS08475	COG0028	Belongs to the TPP enzyme family
HFS01_RS08480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFS01_RS08490	COG2431	L-lysine efflux transmembrane transporter activity
HFS01_RS08495	COG3593	DNA synthesis involved in DNA repair
HFS01_RS08500	COG2990	Protein conserved in bacteria
HFS01_RS08505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS01_RS08510	COG0577	efflux transmembrane transporter activity
HFS01_RS08510	COG1136	(ABC) transporter
HFS01_RS08515	COG1278	Cold shock
HFS01_RS08525	COG0542	response to heat
HFS01_RS08550	COG1335	isochorismatase
HFS01_RS08560	COG0583	DNA-binding transcription factor activity
HFS01_RS08580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HFS01_RS08585	COG4988	ABC transporter
HFS01_RS08590	COG0492	ferredoxin-NADP+ reductase activity
HFS01_RS08610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFS01_RS08620	COG0243	molybdopterin cofactor binding
HFS01_RS08625	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS08630	COG3302	dmso reductase anchor subunit
HFS01_RS08640	COG0531	amino acid
HFS01_RS08645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFS01_RS08660	COG1882	Formate acetyltransferase
HFS01_RS08665	COG2116	formate transmembrane transporter activity
HFS01_RS08670	COG1944	ATP diphosphatase activity
HFS01_RS08675	COG2323	membrane
HFS01_RS08690	COG0501	Belongs to the peptidase M48B family
HFS01_RS08700	COG0539	negative regulation of cytoplasmic translation
HFS01_RS08710	COG2333	competence protein COMEC
HFS01_RS08710	COG0658	competence protein
HFS01_RS08720	COG1663	tetraacyldisaccharide 4'-kinase activity
HFS01_RS08725	COG3214	Protein conserved in bacteria
HFS01_RS08740	COG3173	Aminoglycoside phosphotransferase
HFS01_RS08745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HFS01_RS08750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFS01_RS08760	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HFS01_RS08770	COG2989	Protein conserved in bacteria
HFS01_RS08775	COG3108	Peptidase M15
HFS01_RS08780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFS01_RS08785	COG1448	Aminotransferase
HFS01_RS08790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HFS01_RS08795	COG0017	Asparaginyl-tRNA synthetase
HFS01_RS08800	COG1522	sequence-specific DNA binding
HFS01_RS08810	COG1115	amino acid carrier protein
HFS01_RS08820	COG0582	viral genome integration into host DNA
HFS01_RS08840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFS01_RS08925	COG0484	heat shock protein binding
HFS01_RS08935	COG3772	lysozyme
HFS01_RS09110	COG0308	aminopeptidase N
HFS01_RS09125	COG0633	Ferredoxin
HFS01_RS09125	COG3217	Mosc domain protein beta barrel domain protein
HFS01_RS09135	COG0488	(ABC) transporter
HFS01_RS09140	COG2995	paraquat-inducible protein a
HFS01_RS09145	COG3008	intermembrane lipid transfer
HFS01_RS09145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFS01_RS09150	COG3009	Protein conserved in bacteria
HFS01_RS09155	COG3130	regulation of translation
HFS01_RS09165	COG1067	ATP-dependent peptidase activity
HFS01_RS09185	COG3070	regulator of competence-specific genes
HFS01_RS09190	COG1289	transmembrane transporter activity
HFS01_RS09195	COG3304	Inner membrane component domain
HFS01_RS09200	COG0210	DNA helicase
HFS01_RS09215	COG1832	CoA-binding protein
HFS01_RS09230	COG1881	PFAM PEBP family protein
HFS01_RS09250	COG0670	Belongs to the BI1 family
HFS01_RS09305	COG2205	protein histidine kinase activity
HFS01_RS09310	COG0745	RESPONSE REGULATOR receiver
HFS01_RS09325	COG2368	4-hydroxyphenylacetate
HFS01_RS09330	COG1846	Transcriptional regulator
HFS01_RS09340	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS09345	COG3384	dioxygenase
HFS01_RS09355	COG3971	2-oxopent-4-enoate hydratase activity
HFS01_RS09400	COG4232	protein-disulfide reductase activity
HFS01_RS09405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFS01_RS09405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFS01_RS09410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFS01_RS09430	COG3729	General stress protein
HFS01_RS09435	COG1309	transcriptional regulator
HFS01_RS09455	COG1702	phosphate starvation-inducible protein PhoH
HFS01_RS09475	COG2801	Transposase and inactivated derivatives
HFS01_RS09480	COG2963	transposase activity
HFS01_RS09485	COG2963	transposase activity
HFS01_RS09500	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HFS01_RS09510	COG1418	mRNA catabolic process
HFS01_RS09515	COG0270	DNA (cytosine-5-)-methyltransferase activity
HFS01_RS09520	COG3727	T/G mismatch-specific endonuclease activity
HFS01_RS09525	COG0697	spore germination
HFS01_RS09530	COG2354	Protein conserved in bacteria
HFS01_RS09535	COG5475	Uncharacterized small protein (DUF2158)
HFS01_RS09640	COG0425	Belongs to the sulfur carrier protein TusA family
HFS01_RS09700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS01_RS09710	COG0765	amino acid transport
HFS01_RS09715	COG1126	abc transporter atp-binding protein
HFS01_RS09720	COG2197	response regulator
HFS01_RS09735	COG2197	response regulator
HFS01_RS09780	COG3012	SEC-C Motif Domain Protein
HFS01_RS09780	COG3318	Belongs to the UPF0149 family
HFS01_RS09785	COG0814	amino acid
HFS01_RS09795	COG1528	Iron-storage protein
HFS01_RS09810	COG1528	Iron-storage protein
HFS01_RS09915	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HFS01_RS09930	COG3102	Protein conserved in bacteria
HFS01_RS09950	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HFS01_RS09955	COG1801	Protein of unknown function DUF72
HFS01_RS09960	COG1335	isochorismatase
HFS01_RS09970	COG0494	nUDIX hydrolase
HFS01_RS10005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFS01_RS10015	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HFS01_RS10020	COG0739	heme binding
HFS01_RS10025	COG1560	Kdo2-lipid A biosynthetic process
HFS01_RS10035	COG1737	Transcriptional regulator
HFS01_RS10040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFS01_RS10045	COG0129	dihydroxy-acid dehydratase activity
HFS01_RS10050	COG0800	Aldolase
HFS01_RS10060	COG3141	response to X-ray
HFS01_RS10070	COG2979	Protein of unknown function (DUF533)
HFS01_RS10075	COG1770	oligopeptidase
HFS01_RS10080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFS01_RS10085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFS01_RS10095	COG2372	response to copper ion
HFS01_RS10100	COG1276	copper resistance
HFS01_RS10135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFS01_RS10150	COG5499	transcription regulator containing HTH domain
HFS01_RS10155	COG4680	protein conserved in bacteria
HFS01_RS10190	COG5562	phage envelope protein
HFS01_RS10225	COG3008	intermembrane lipid transfer
HFS01_RS10230	COG2995	paraquat-inducible protein a
HFS01_RS10235	COG1956	GAF domain-containing protein
HFS01_RS10255	COG2814	Major facilitator Superfamily
HFS01_RS10260	COG1414	Transcriptional regulator
HFS01_RS10290	COG0768	penicillin binding
HFS01_RS10295	COG2226	methyltransferase
HFS01_RS10310	COG3716	PTS system mannose fructose sorbose family IID component
HFS01_RS10315	COG3715	PTS system
HFS01_RS10320	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS10320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS01_RS10325	COG1253	flavin adenine dinucleotide binding
HFS01_RS10330	COG2200	EAL domain
HFS01_RS10335	COG1760	l-serine dehydratase
HFS01_RS10355	COG0251	oxidation-reduction process
HFS01_RS10360	COG1199	ATP-dependent helicase activity
HFS01_RS10370	COG3065	identical protein binding
HFS01_RS10380	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HFS01_RS10390	COG2894	cell division
HFS01_RS10405	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFS01_RS10445	COG2719	SpoVR family
HFS01_RS10465	COG1619	proteins homologs of microcin C7 resistance protein MccF
HFS01_RS10490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFS01_RS10500	COG1294	oxidase, subunit
HFS01_RS10505	COG1271	oxidase subunit
HFS01_RS10510	COG1773	rubredoxin
HFS01_RS10515	COG1999	signal sequence binding
HFS01_RS10520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HFS01_RS10525	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HFS01_RS10535	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HFS01_RS10555	COG0012	GTP binding
HFS01_RS10570	COG0659	secondary active sulfate transmembrane transporter activity
HFS01_RS10620	COG0387	Pfam Sodium calcium exchanger
HFS01_RS10625	COG4572	Cation transport regulator
HFS01_RS10630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HFS01_RS10635	COG4932	domain protein
HFS01_RS10640	COG2197	response regulator
HFS01_RS10645	COG3850	Histidine kinase
HFS01_RS10650	COG2223	nitrite transmembrane transporter activity
HFS01_RS10655	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HFS01_RS10660	COG1140	nitrate reductase beta subunit
HFS01_RS10665	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HFS01_RS10670	COG2181	nitrate reductase activity
HFS01_RS10710	COG0788	formyltetrahydrofolate deformylase activity
HFS01_RS10720	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFS01_RS10725	COG0745	RESPONSE REGULATOR receiver
HFS01_RS10730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFS01_RS10745	COG1454	alcohol dehydrogenase
HFS01_RS10745	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS10750	COG2095	MarC family integral membrane protein
HFS01_RS10780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFS01_RS10800	COG2350	Protein conserved in bacteria
HFS01_RS10825	COG0727	PFAM Uncharacterised protein family (UPF0153)
HFS01_RS10830	COG3047	cAMP biosynthetic process
HFS01_RS10835	COG3546	catalase activity
HFS01_RS10840	COG3685	Protein conserved in bacteria
HFS01_RS10845	COG3685	Protein conserved in bacteria
HFS01_RS10850	COG3729	General stress protein
HFS01_RS10890	COG0009	L-threonylcarbamoyladenylate synthase
HFS01_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS10910	COG0616	signal peptide processing
HFS01_RS10950	COG0671	phosphoesterase, PA-phosphatase related
HFS01_RS10955	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HFS01_RS10960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HFS01_RS10980	COG1349	DNA-binding transcription factor activity
HFS01_RS10990	COG5001	Diguanylate cyclase
HFS01_RS11000	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFS01_RS11000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFS01_RS11055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HFS01_RS11060	COG1842	Phage shock protein A
HFS01_RS11070	COG1983	PspC domain protein
HFS01_RS11080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFS01_RS11085	COG3106	COG3106 Predicted ATPase
HFS01_RS11105	COG4948	Mandelate Racemase Muconate Lactonizing
HFS01_RS11110	COG2866	Carboxypeptidase
HFS01_RS11115	COG4166	transmembrane transport
HFS01_RS11120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFS01_RS11135	COG3302	dmso reductase anchor subunit
HFS01_RS11140	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS11145	COG0243	molybdopterin cofactor binding
HFS01_RS11160	COG4948	Mandelate Racemase Muconate Lactonizing
HFS01_RS11165	COG0814	amino acid
HFS01_RS11170	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS11175	COG2814	Major facilitator Superfamily
HFS01_RS11185	COG0583	DNA-binding transcription factor activity
HFS01_RS11195	COG0656	L-ascorbic acid biosynthetic process
HFS01_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS11205	COG1309	transcriptional regulator
HFS01_RS11240	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HFS01_RS11260	COG0668	transmembrane transport
HFS01_RS11265	COG3182	Iron-regulated membrane protein
HFS01_RS11285	COG2840	Smr protein MutS2
HFS01_RS11290	COG0840	transmembrane signaling receptor activity
HFS01_RS11300	COG0513	Belongs to the DEAD box helicase family
HFS01_RS11320	COG2076	Multidrug Resistance protein
HFS01_RS11330	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFS01_RS11330	COG1013	pyruvate-flavodoxin oxidoreductase activity
HFS01_RS11330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HFS01_RS11330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFS01_RS11340	COG3042	response to heat
HFS01_RS11345	COG3187	Heat shock protein
HFS01_RS11350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFS01_RS11355	COG2911	Protein conserved in bacteria
HFS01_RS11365	COG3784	Protein of unknown function (DUF1318)
HFS01_RS11380	COG1643	Atp-dependent helicase
HFS01_RS11385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HFS01_RS11390	COG3038	cytochrome b561
HFS01_RS11395	COG0500	methyltransferase
HFS01_RS11405	COG0765	amino acid transport
HFS01_RS11415	COG0765	amino acid transport
HFS01_RS11420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS01_RS11455	COG0840	transmembrane signaling receptor activity
HFS01_RS11460	COG0583	DNA-binding transcription factor activity
HFS01_RS11465	COG5383	Protein conserved in bacteria
HFS01_RS11470	COG2272	Belongs to the type-B carboxylesterase lipase family
HFS01_RS11480	COG2353	YceI-like domain
HFS01_RS11485	COG1304	FMN binding
HFS01_RS11495	COG1349	DNA-binding transcription factor activity
HFS01_RS11500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFS01_RS11505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS11510	COG0434	BtpA family
HFS01_RS11515	COG3775	system Galactitol-specific IIC component
HFS01_RS11520	COG3414	Phosphotransferase system galactitol-specific IIB component
HFS01_RS11530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFS01_RS11535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFS01_RS11540	COG1275	C4-dicarboxylate transporter malic acid transport protein
HFS01_RS11545	COG0500	methyltransferase
HFS01_RS11555	COG3135	benzoate transporter
HFS01_RS11560	COG1396	sequence-specific DNA binding
HFS01_RS11565	COG0826	peptidase U32
HFS01_RS11590	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HFS01_RS11595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFS01_RS11635	COG3238	Protein conserved in bacteria
HFS01_RS11645	COG2130	NADP-dependent
HFS01_RS11650	COG1802	Transcriptional regulator
HFS01_RS11655	COG4772	TonB-dependent receptor
HFS01_RS11690	COG2181	nitrate reductase activity
HFS01_RS11695	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HFS01_RS11700	COG1140	nitrate reductase beta subunit
HFS01_RS11705	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HFS01_RS11750	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS11755	COG2864	formate dehydrogenase
HFS01_RS11760	COG1064	alcohol dehydrogenase
HFS01_RS11780	COG1764	response to oxidative stress
HFS01_RS11795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HFS01_RS11810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HFS01_RS11815	COG1757	Na H antiporter
HFS01_RS11820	COG1609	Transcriptional regulator
HFS01_RS11995	COG0251	oxidation-reduction process
HFS01_RS12000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HFS01_RS12025	COG2271	Major facilitator Superfamily
HFS01_RS12030	COG1063	alcohol dehydrogenase
HFS01_RS12035	COG2186	Transcriptional regulator
HFS01_RS12045	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HFS01_RS12050	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HFS01_RS12075	COG1773	rubredoxin
HFS01_RS12100	COG3781	membrane
HFS01_RS12115	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS12120	COG0583	DNA-binding transcription factor activity
HFS01_RS12155	COG2814	Major facilitator Superfamily
HFS01_RS12165	COG3111	PFAM Bacterial OB fold (BOF) protein
HFS01_RS12170	COG1546	Belongs to the CinA family
HFS01_RS12175	COG3729	General stress protein
HFS01_RS12185	COG4221	oxidoreductase activity
HFS01_RS12190	COG1802	Transcriptional regulator
HFS01_RS12200	COG0246	Mannitol dehydrogenase
HFS01_RS12205	COG0477	Major facilitator Superfamily
HFS01_RS12210	COG1063	alcohol dehydrogenase
HFS01_RS12230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFS01_RS12245	COG0243	molybdopterin cofactor binding
HFS01_RS12250	COG0243	molybdopterin cofactor binding
HFS01_RS12255	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS12260	COG3302	dmso reductase anchor subunit
HFS01_RS12300	COG1940	carbohydrate kinase activity
HFS01_RS12305	COG0583	DNA-binding transcription factor activity
HFS01_RS12310	COG2814	Major facilitator Superfamily
HFS01_RS12320	COG3591	Belongs to the peptidase S1B family
HFS01_RS12335	COG0628	permease
HFS01_RS12340	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HFS01_RS12345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HFS01_RS12355	COG0531	amino acid
HFS01_RS12360	COG3136	membrane protein required for alginate biosynthesis
HFS01_RS12365	COG0745	RESPONSE REGULATOR receiver
HFS01_RS12370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HFS01_RS12375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HFS01_RS12380	COG2205	protein histidine kinase activity
HFS01_RS12405	COG5339	Protein conserved in bacteria
HFS01_RS12475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFS01_RS12485	COG0625	glutathione transferase activity
HFS01_RS12505	COG3895	Periplasmic Protein
HFS01_RS12530	COG1566	PFAM secretion protein HlyD family protein
HFS01_RS12545	COG4989	oxidoreductase activity
HFS01_RS12550	COG3313	Fe-S protein
HFS01_RS12555	COG1309	transcriptional regulator
HFS01_RS12560	COG1902	pentaerythritol trinitrate reductase activity
HFS01_RS12575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HFS01_RS12580	COG0791	NLP P60 protein
HFS01_RS12600	COG0583	DNA-binding transcription factor activity
HFS01_RS12605	COG2814	Major facilitator Superfamily
HFS01_RS12610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HFS01_RS12615	COG0307	riboflavin synthase, alpha
HFS01_RS12795	COG0789	Transcriptional regulator
HFS01_RS12800	COG3272	Protein of unknown function (DUF1722)
HFS01_RS12835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS12845	COG2267	carboxylic ester hydrolase activity
HFS01_RS12850	COG0531	amino acid
HFS01_RS12865	COG4238	major outer membrane lipoprotein
HFS01_RS12870	COG1376	ErfK ybiS ycfS ynhG family protein
HFS01_RS12885	COG0719	Fe-S assembly protein
HFS01_RS12890	COG0396	ATPase activity
HFS01_RS12895	COG0719	Fe-S assembly protein
HFS01_RS12900	COG0316	Belongs to the HesB IscA family
HFS01_RS12905	COG1823	symporter activity
HFS01_RS12915	COG2050	protein possibly involved in aromatic compounds catabolism
HFS01_RS12920	COG0247	lactate metabolic process
HFS01_RS12920	COG0277	FAD linked oxidase domain protein
HFS01_RS12925	COG0628	permease
HFS01_RS12940	COG0738	Major facilitator superfamily
HFS01_RS12945	COG2271	Major facilitator Superfamily
HFS01_RS12960	COG4670	ketone body catabolic process
HFS01_RS12965	COG1960	acyl-CoA dehydrogenase activity
HFS01_RS12970	COG2207	Transcriptional regulator
HFS01_RS12970	COG1917	Cupin 2, conserved barrel domain protein
HFS01_RS12975	COG2086	electron transfer activity
HFS01_RS12980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFS01_RS12985	COG0644	oxidoreductase
HFS01_RS12990	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HFS01_RS12995	COG0318	PFAM AMP-dependent synthetase and ligase
HFS01_RS13000	COG0574	Belongs to the PEP-utilizing enzyme family
HFS01_RS13000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFS01_RS13015	COG4256	Hemin uptake protein
HFS01_RS13030	COG0791	NLP P60 protein
HFS01_RS13040	COG0386	Belongs to the glutathione peroxidase family
HFS01_RS13105	COG3137	Salt-induced outer membrane protein
HFS01_RS13110	COG1105	Belongs to the carbohydrate kinase PfkB family
HFS01_RS13120	COG3001	Fructosamine kinase
HFS01_RS13130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFS01_RS13135	COG1988	membrane-bound metal-dependent
HFS01_RS13140	COG1823	symporter activity
HFS01_RS13150	COG0753	catalase activity
HFS01_RS13160	COG1486	melibiose metabolic process
HFS01_RS13165	COG2169	Transcriptional regulator
HFS01_RS13165	COG1917	Cupin 2, conserved barrel domain protein
HFS01_RS13170	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFS01_RS13175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFS01_RS13180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFS01_RS13185	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFS01_RS13195	COG0322	excinuclease ABC activity
HFS01_RS13200	COG3678	ATP-independent chaperone mediated protein folding
HFS01_RS13210	COG3724	N-succinylarginine dihydrolase activity
HFS01_RS13235	COG0494	nUDIX hydrolase
HFS01_RS13260	COG0778	Nitroreductase
HFS01_RS13265	COG0616	signal peptide processing
HFS01_RS13270	COG0252	asparaginase activity
HFS01_RS13275	COG1335	isochorismatase
HFS01_RS13280	COG3139	Protein of unknown function (DUF1315)
HFS01_RS13300	COG0656	L-ascorbic acid biosynthetic process
HFS01_RS13305	COG0641	radical SAM
HFS01_RS13310	COG3713	MltA-interacting MipA family protein
HFS01_RS13315	COG2766	serine protein kinase
HFS01_RS13330	COG2199	diguanylate cyclase activity
HFS01_RS13335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFS01_RS13350	COG2207	Transcriptional regulator
HFS01_RS13355	COG2807	transmembrane transport
HFS01_RS13360	COG3189	MarR family transcriptional regulator
HFS01_RS13370	COG3042	response to heat
HFS01_RS13380	COG2261	transglycosylase associated protein
HFS01_RS13395	COG3615	Tellurite resistance protein tehB
HFS01_RS13405	COG1605	Chorismate mutase
HFS01_RS13415	COG0789	Transcriptional regulator
HFS01_RS13430	COG3443	Belongs to the bacterial solute-binding protein 9 family
HFS01_RS13445	COG0668	transmembrane transport
HFS01_RS13450	COG1124	(ABC) transporter
HFS01_RS13470	COG0747	negative chemotaxis
HFS01_RS13480	COG3038	cytochrome b561
HFS01_RS13490	COG0071	Belongs to the small heat shock protein (HSP20) family
HFS01_RS13555	COG0538	isocitrate dehydrogenase activity
HFS01_RS13585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFS01_RS13600	COG2850	peptidyl-arginine hydroxylation
HFS01_RS13630	COG1177	transmembrane transport
HFS01_RS13650	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFS01_RS13655	COG1136	(ABC) transporter
HFS01_RS13660	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFS01_RS13665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFS01_RS13670	COG1376	ErfK ybiS ycfS ynhG family protein
HFS01_RS13670	COG1388	LysM domain
HFS01_RS13680	COG1309	transcriptional regulator
HFS01_RS13685	COG3134	Outer membrane lipoprotein
HFS01_RS13690	COG1252	NADH dehydrogenase
HFS01_RS13715	COG5633	Lipoprotein
HFS01_RS13720	COG0537	adenosine 5'-monophosphoramidase activity
HFS01_RS13725	COG4773	Receptor
HFS01_RS13735	COG0084	hydrolase, TatD family'
HFS01_RS13740	COG0470	DNA polymerase III
HFS01_RS13750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFS01_RS13755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFS01_RS13760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFS01_RS13820	COG1530	ribonuclease E activity
HFS01_RS13910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFS01_RS13920	COG2999	glutathione oxidoreductase activity
HFS01_RS13955	COG3038	cytochrome b561
HFS01_RS13970	COG1560	Kdo2-lipid A biosynthetic process
HFS01_RS13985	COG5645	(Lipo)protein
HFS01_RS13990	COG2943	transferase activity, transferring hexosyl groups
HFS01_RS14005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFS01_RS14060	COG3381	protein complex oligomerization
HFS01_RS14145	COG0582	viral genome integration into host DNA
HFS01_RS14160	COG3423	Transcriptional regulator
HFS01_RS14245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFS01_RS14285	COG0798	PFAM Bile acid sodium symporter
HFS01_RS14300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFS01_RS14305	COG0640	Transcriptional regulator
HFS01_RS14465	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HFS01_RS14480	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HFS01_RS14495	COG1454	alcohol dehydrogenase
HFS01_RS14495	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS14500	COG4656	Part of a membrane complex involved in electron transport
HFS01_RS14535	COG1289	transmembrane transporter activity
HFS01_RS14575	COG2925	Exonuclease
HFS01_RS14580	COG0531	amino acid
HFS01_RS14590	COG0583	DNA-binding transcription factor activity
HFS01_RS14595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFS01_RS14725	COG2327	Polysaccharide pyruvyl transferase
HFS01_RS14730	COG2244	polysaccharide biosynthetic process
HFS01_RS14735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFS01_RS14750	COG0297	glycogen (starch) synthase activity
HFS01_RS14760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFS01_RS14765	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HFS01_RS14770	COG0110	maltose O-acetyltransferase activity
HFS01_RS14775	COG1216	Glycosyl transferase, family 2
HFS01_RS14785	COG0438	transferase activity, transferring glycosyl groups
HFS01_RS14790	COG1045	serine acetyltransferase
HFS01_RS14795	COG0463	Glycosyl transferase, family 2
HFS01_RS14815	COG1253	flavin adenine dinucleotide binding
HFS01_RS14820	COG2982	Protein involved in outer membrane biogenesis
HFS01_RS14835	COG5002	protein histidine kinase activity
HFS01_RS14835	COG5001	Diguanylate cyclase
HFS01_RS14835	COG3447	MASE1 domain protein
HFS01_RS14840	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HFS01_RS14845	COG0443	Heat shock 70 kDa protein
HFS01_RS14875	COG2205	protein histidine kinase activity
HFS01_RS14880	COG0745	RESPONSE REGULATOR receiver
HFS01_RS14925	COG3209	COG3209 Rhs family protein
HFS01_RS14930	COG3209	COG3209 Rhs family protein
HFS01_RS14945	COG3209	COG3209 Rhs family protein
HFS01_RS14970	COG0826	peptidase U32
HFS01_RS14995	COG1830	Aldolase
HFS01_RS15000	COG2211	Major facilitator Superfamily
HFS01_RS15005	COG1397	ADP-ribosylglycohydrolase
HFS01_RS15010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS15015	COG2188	Transcriptional regulator
HFS01_RS15030	COG5455	response to cobalt ion
HFS01_RS15035	COG3539	Fimbrial protein
HFS01_RS15040	COG3188	usher protein
HFS01_RS15045	COG3121	Chaperone
HFS01_RS15070	COG4808	Protein conserved in bacteria
HFS01_RS15080	COG4807	Protein conserved in bacteria
HFS01_RS15090	COG3275	phosphorelay sensor kinase activity
HFS01_RS15105	COG1174	glycine betaine transport
HFS01_RS15110	COG1125	glycine betaine transport
HFS01_RS15115	COG1174	glycine betaine transport
HFS01_RS15120	COG1732	Glycine betaine
HFS01_RS15130	COG0277	FAD linked oxidase domain protein
HFS01_RS15135	COG1686	Belongs to the peptidase S11 family
HFS01_RS15145	COG0586	Pfam SNARE associated Golgi protein
HFS01_RS15150	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS15155	COG1538	Outer membrane efflux protein
HFS01_RS15170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFS01_RS15175	COG0625	glutathione transferase activity
HFS01_RS15190	COG2271	Major facilitator Superfamily
HFS01_RS15205	COG1346	cytolysis
HFS01_RS15215	COG2949	membrane
HFS01_RS15255	COG2311	Membrane
HFS01_RS15275	COG1760	l-serine dehydratase
HFS01_RS15280	COG0560	Phosphoserine phosphatase
HFS01_RS15285	COG2271	Major facilitator Superfamily
HFS01_RS15290	COG4771	TonB-dependent receptor
HFS01_RS15295	COG0833	amino acid
HFS01_RS15300	COG0583	DNA-binding transcription factor activity
HFS01_RS15305	COG2855	membrane
HFS01_RS15315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFS01_RS15315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFS01_RS15315	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFS01_RS15320	COG1105	Belongs to the carbohydrate kinase PfkB family
HFS01_RS15355	COG0523	cobalamin synthesis protein
HFS01_RS15360	COG0671	phosphoesterase, PA-phosphatase related
HFS01_RS15365	COG0791	NLP P60 protein
HFS01_RS15370	COG2200	EAL domain
HFS01_RS15375	COG4166	transmembrane transport
HFS01_RS15380	COG4174	ABC transporter (Permease)
HFS01_RS15385	COG4239	(ABC) transporter, permease
HFS01_RS15390	COG4172	Belongs to the ABC transporter superfamily
HFS01_RS15400	COG2814	Major facilitator Superfamily
HFS01_RS15410	COG1061	Type III restriction enzyme res subunit
HFS01_RS15455	COG2197	response regulator
HFS01_RS15460	COG3088	subunit of a heme lyase
HFS01_RS15460	COG4235	cytochrome complex assembly
HFS01_RS15465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFS01_RS15470	COG1138	Cytochrome C-type biogenesis protein
HFS01_RS15480	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS01_RS15485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFS01_RS15500	COG3005	denitrification pathway
HFS01_RS15505	COG3043	anaerobic respiration
HFS01_RS15510	COG0348	domain, Protein
HFS01_RS15515	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS15525	COG3062	negative regulation of establishment of protein localization
HFS01_RS15530	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS01_RS15530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS01_RS15540	COG4615	Cyclic peptide transporter
HFS01_RS15565	COG0642	Histidine kinase
HFS01_RS15565	COG2198	Histidine kinase
HFS01_RS15585	COG4948	Mandelate Racemase Muconate Lactonizing
HFS01_RS15615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFS01_RS15620	COG2814	Major facilitator Superfamily
HFS01_RS15625	COG0583	DNA-binding transcription factor activity
HFS01_RS15630	COG0584	glycerophosphoryl diester phosphodiesterase
HFS01_RS15635	COG2271	Major facilitator Superfamily
HFS01_RS15640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HFS01_RS15650	COG0247	lactate metabolic process
HFS01_RS15670	COG2271	Major facilitator Superfamily
HFS01_RS15680	COG1414	Transcriptional regulator
HFS01_RS15770	COG1169	isochorismate synthase
HFS01_RS15775	COG4575	ribosome binding
HFS01_RS15780	COG2153	protein acetylation
HFS01_RS15790	COG0784	Response regulator, receiver
HFS01_RS15790	COG0835	chemotaxis
HFS01_RS15795	COG2304	oxidoreductase activity
HFS01_RS15810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFS01_RS15815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFS01_RS15825	COG0839	Belongs to the complex I subunit 6 family
HFS01_RS15875	COG0583	DNA-binding transcription factor activity
HFS01_RS15880	COG0436	Aminotransferase
HFS01_RS15890	COG0490	domain, Protein
HFS01_RS15890	COG0471	metal ion transport
HFS01_RS15895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFS01_RS15920	COG1288	antiporter activity
HFS01_RS15925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HFS01_RS15930	COG3959	Transketolase, thiamine diphosphate binding domain
HFS01_RS15935	COG3037	sugar-specific permease SgaT UlaA
HFS01_RS15945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS15950	COG1609	Transcriptional regulator
HFS01_RS15960	COG0622	Phosphoesterase
HFS01_RS15965	COG0625	glutathione transferase activity
HFS01_RS15970	COG0625	glutathione transferase activity
HFS01_RS15975	COG1090	epimerase
HFS01_RS16010	COG0833	amino acid
HFS01_RS16015	COG3457	Alanine racemase
HFS01_RS16020	COG0531	amino acid
HFS01_RS16030	COG3829	transcription factor binding
HFS01_RS16035	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFS01_RS16040	COG1286	toxin biosynthetic process
HFS01_RS16045	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HFS01_RS16050	COG0285	dihydrofolate synthase activity
HFS01_RS16060	COG0586	Pfam SNARE associated Golgi protein
HFS01_RS16070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HFS01_RS16110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFS01_RS16125	COG3101	peptidyl-lysine hydroxylation
HFS01_RS16130	COG0730	response to heat
HFS01_RS16155	COG2062	phosphohistidine phosphatase, SixA
HFS01_RS16170	COG3691	Protein conserved in bacteria
HFS01_RS16185	COG2116	formate transmembrane transporter activity
HFS01_RS16225	COG1560	Kdo2-lipid A biosynthetic process
HFS01_RS16235	COG0436	Aminotransferase
HFS01_RS16250	COG3961	Belongs to the TPP enzyme family
HFS01_RS16255	COG0667	Aldo Keto reductase
HFS01_RS16270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFS01_RS16275	COG2200	EAL domain
HFS01_RS16275	COG2199	diguanylate cyclase activity
HFS01_RS16290	COG3415	Transposase
HFS01_RS16295	COG3415	Transposase
HFS01_RS16325	COG0583	DNA-binding transcription factor activity
HFS01_RS16335	COG2211	Major facilitator Superfamily
HFS01_RS16340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HFS01_RS16350	COG0583	DNA-binding transcription factor activity
HFS01_RS16355	COG0385	Bile acid
HFS01_RS16360	COG3530	Putative quorum-sensing-regulated virulence factor
HFS01_RS16385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS16440	COG4208	sulfate ABC transporter
HFS01_RS16460	COG2837	iron assimilation
HFS01_RS16595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFS01_RS16605	COG5342	invasion associated locus B
HFS01_RS16620	COG0493	'glutamate synthase
HFS01_RS16620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS01_RS16625	COG3850	Histidine kinase
HFS01_RS16630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFS01_RS16640	COG1393	Belongs to the ArsC family
HFS01_RS16660	COG2321	neutral zinc metallopeptidase
HFS01_RS16670	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HFS01_RS16680	COG2716	regulation of RNA biosynthetic process
HFS01_RS16685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFS01_RS16690	COG1929	Belongs to the glycerate kinase type-1 family
HFS01_RS16695	COG2610	gluconate transmembrane transporter activity
HFS01_RS16700	COG3835	regulator
HFS01_RS16705	COG0628	permease
HFS01_RS16715	COG1393	Belongs to the ArsC family
HFS01_RS16725	COG2233	PERMEase
HFS01_RS16740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFS01_RS16755	COG2200	EAL domain
HFS01_RS16770	COG3133	Outer membrane lipoprotein
HFS01_RS16835	COG3547	Transposase (IS116 IS110 IS902 family)
HFS01_RS16855	COG0517	IMP dehydrogenase activity
HFS01_RS16855	COG0516	GMP reductase activity
HFS01_RS16890	COG1645	bacterial-type flagellum-dependent swarming motility
HFS01_RS16905	COG2976	Protein conserved in bacteria
HFS01_RS16945	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS16950	COG0243	molybdopterin cofactor binding
HFS01_RS16955	COG4953	penicillin-binding protein 1C
HFS01_RS16960	COG2373	Large extracellular alpha-helical protein
HFS01_RS16965	COG2897	thiosulfate sulfurtransferase activity
HFS01_RS16990	COG2975	iron-sulfur cluster assembly
HFS01_RS16995	COG0633	Ferredoxin
HFS01_RS17015	COG0822	iron-sulfur transferase activity
HFS01_RS17060	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HFS01_RS17070	COG3711	transcriptional antiterminator
HFS01_RS17075	COG2814	Major facilitator Superfamily
HFS01_RS17085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFS01_RS17085	COG1017	nitric oxide dioxygenase activity
HFS01_RS17090	COG3710	Transcriptional regulator
HFS01_RS17095	COG0531	amino acid
HFS01_RS17105	COG3104	oligopeptide transport
HFS01_RS17110	COG0347	Belongs to the P(II) protein family
HFS01_RS17115	COG2204	response regulator
HFS01_RS17120	COG3170	Tfp pilus assembly protein FimV
HFS01_RS17125	COG2205	protein histidine kinase activity
HFS01_RS17150	COG0560	Phosphoserine phosphatase
HFS01_RS17155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS01_RS17155	COG1263	PTS System
HFS01_RS17165	COG1737	Transcriptional regulator
HFS01_RS17170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFS01_RS17175	COG2223	nitrite transmembrane transporter activity
HFS01_RS17180	COG0583	DNA-binding transcription factor activity
HFS01_RS17185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS01_RS17195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HFS01_RS17225	COG3086	response to oxidative stress
HFS01_RS17250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HFS01_RS17260	COG0513	Belongs to the DEAD box helicase family
HFS01_RS17265	COG0583	DNA-binding transcription factor activity
HFS01_RS17285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFS01_RS17290	COG3118	belongs to the thioredoxin family
HFS01_RS17295	COG3148	PFAM DTW domain containing protein
HFS01_RS17305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFS01_RS17310	COG5544	Lipoprotein
HFS01_RS17315	COG0477	Major facilitator Superfamily
HFS01_RS17345	COG0542	response to heat
HFS01_RS17360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFS01_RS17365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HFS01_RS17375	COG0077	Prephenate dehydratase
HFS01_RS17375	COG1605	Chorismate mutase
HFS01_RS17385	COG0287	Prephenate dehydrogenase
HFS01_RS17385	COG1605	Chorismate mutase
HFS01_RS17400	COG2199	diguanylate cyclase activity
HFS01_RS17425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFS01_RS17430	COG4137	Cytochrome C assembly protein
HFS01_RS17435	COG4536	flavin adenine dinucleotide binding
HFS01_RS17455	COG0497	DNA recombination
HFS01_RS17470	COG2867	negative regulation of translational initiation
HFS01_RS17495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFS01_RS17545	COG2819	hydrolase of the alpha beta superfamily
HFS01_RS17565	COG2990	Protein conserved in bacteria
HFS01_RS17575	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HFS01_RS17610	COG0579	oxidoreductase
HFS01_RS17615	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS17620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFS01_RS17625	COG1113	amino acid transport
HFS01_RS17630	COG1802	Transcriptional regulator
HFS01_RS17635	COG1652	LysM domain
HFS01_RS17640	COG0401	homolog of Blt101
HFS01_RS17645	COG0640	Transcriptional regulator
HFS01_RS17650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFS01_RS17675	COG4575	ribosome binding
HFS01_RS17685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFS01_RS17725	COG2814	Major facilitator Superfamily
HFS01_RS17730	COG1846	Transcriptional regulator
HFS01_RS17735	COG1566	PFAM secretion protein HlyD family protein
HFS01_RS17740	COG2814	Major facilitator Superfamily
HFS01_RS17760	COG1238	metal cluster binding
HFS01_RS17765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFS01_RS17795	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HFS01_RS17815	COG1546	Belongs to the CinA family
HFS01_RS17820	COG2951	lytic endotransglycosylase activity
HFS01_RS17825	COG3730	PTS system glucitol sorbitol-specific
HFS01_RS17830	COG3732	PTS system glucitol sorbitol-specific
HFS01_RS17840	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS17845	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS17850	COG1349	DNA-binding transcription factor activity
HFS01_RS17855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFS01_RS17855	COG0517	IMP dehydrogenase activity
HFS01_RS17875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HFS01_RS17880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS01_RS17890	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HFS01_RS17900	COG3260	NADH ubiquinone oxidoreductase 20
HFS01_RS17905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFS01_RS17910	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HFS01_RS17910	COG3261	NADH dehydrogenase
HFS01_RS17915	COG0650	Formate hydrogenlyase subunit 4
HFS01_RS17920	COG0651	ATP synthesis coupled electron transport
HFS01_RS17925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFS01_RS17940	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HFS01_RS17945	COG0298	carbon dioxide binding
HFS01_RS17950	COG0409	Hydrogenase expression formation protein
HFS01_RS17955	COG0309	Hydrogenase expression formation protein (HypE)
HFS01_RS17975	COG1121	(ABC) transporter
HFS01_RS17980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFS01_RS17985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFS01_RS18070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFS01_RS18160	COG2207	Transcriptional regulator
HFS01_RS18235	COG0477	Major facilitator Superfamily
HFS01_RS18245	COG2610	gluconate transmembrane transporter activity
HFS01_RS18250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFS01_RS18255	COG3622	Belongs to the hyi family
HFS01_RS18260	COG0235	Class ii aldolase
HFS01_RS18270	COG2084	Dehydrogenase
HFS01_RS18275	COG1349	DNA-binding transcription factor activity
HFS01_RS18285	COG0163	prenyltransferase activity
HFS01_RS18290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HFS01_RS18360	COG2234	aminopeptidase activity
HFS01_RS18365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFS01_RS18370	COG1518	maintenance of DNA repeat elements
HFS01_RS18385	COG1857	crispr-associated protein
HFS01_RS18400	COG1203	CRISPR-associated helicase, Cas3
HFS01_RS18420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFS01_RS18425	COG0720	synthase
HFS01_RS18430	COG0321	lipoyl(octanoyl) transferase activity
HFS01_RS18430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HFS01_RS18435	COG0602	queuosine metabolic process
HFS01_RS18450	COG3956	TIGRFAM MazG family protein
HFS01_RS18455	COG3539	Fimbrial protein
HFS01_RS18460	COG3188	usher protein
HFS01_RS18465	COG3121	Chaperone
HFS01_RS18470	COG3539	Fimbrial protein
HFS01_RS18505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFS01_RS18515	COG3437	response regulator, receiver
HFS01_RS18515	COG2205	protein histidine kinase activity
HFS01_RS18515	COG4999	Histidine kinase
HFS01_RS18515	COG3850	Histidine kinase
HFS01_RS18520	COG1929	Belongs to the glycerate kinase type-1 family
HFS01_RS18525	COG4948	Mandelate Racemase Muconate Lactonizing
HFS01_RS18530	COG4948	Mandelate Racemase Muconate Lactonizing
HFS01_RS18535	COG2271	Major facilitator Superfamily
HFS01_RS18540	COG0716	FMN binding
HFS01_RS18550	COG3098	single-species biofilm formation
HFS01_RS18565	COG1611	Belongs to the LOG family
HFS01_RS18570	COG0814	amino acid
HFS01_RS18575	COG1760	l-serine dehydratase
HFS01_RS18585	COG1454	alcohol dehydrogenase
HFS01_RS18590	COG0235	Class ii aldolase
HFS01_RS18595	COG0738	Major facilitator superfamily
HFS01_RS18615	COG1349	DNA-binding transcription factor activity
HFS01_RS18625	COG2363	Small membrane protein
HFS01_RS18630	COG0583	DNA-binding transcription factor activity
HFS01_RS18640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFS01_RS18645	COG2166	iron-sulfur cluster assembly
HFS01_RS18650	COG2962	Rard protein
HFS01_RS18655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HFS01_RS18660	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HFS01_RS18675	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFS01_RS18685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFS01_RS18690	COG1074	ATP-dependent DNA helicase activity
HFS01_RS18695	COG1025	Belongs to the peptidase M16 family
HFS01_RS18700	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HFS01_RS18705	COG4967	type IV pilus modification protein PilV
HFS01_RS18715	COG4795	General secretion pathway protein
HFS01_RS18720	COG2165	general secretion pathway protein
HFS01_RS18750	COG0861	Integral membrane protein TerC family
HFS01_RS18760	COG0667	Aldo Keto reductase
HFS01_RS18780	COG1609	Transcriptional regulator
HFS01_RS18790	COG0583	DNA-binding transcription factor activity
HFS01_RS18795	COG1794	racemase activity, acting on amino acids and derivatives
HFS01_RS18800	COG2814	Major facilitator Superfamily
HFS01_RS18805	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS18815	COG0183	Belongs to the thiolase family
HFS01_RS18830	COG0814	amino acid
HFS01_RS18865	COG3188	usher protein
HFS01_RS18900	COG4942	peptidase
HFS01_RS18955	COG1272	protein, Hemolysin III
HFS01_RS18965	COG2723	6-phospho-beta-galactosidase activity
HFS01_RS18990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFS01_RS18995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFS01_RS19000	COG0006	proline dipeptidase activity
HFS01_RS19020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFS01_RS19025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFS01_RS19040	COG2968	Membrane
HFS01_RS19050	COG0668	transmembrane transport
HFS01_RS19055	COG0191	fructose-bisphosphate aldolase activity
HFS01_RS19085	COG1122	ATPase activity
HFS01_RS19090	COG1122	ATPase activity
HFS01_RS19095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFS01_RS19100	COG0501	Belongs to the peptidase M48B family
HFS01_RS19110	COG2267	carboxylic ester hydrolase activity
HFS01_RS19115	COG2731	YhcH YjgK YiaL family protein
HFS01_RS19120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HFS01_RS19125	COG1063	alcohol dehydrogenase
HFS01_RS19130	COG0246	Mannitol dehydrogenase
HFS01_RS19140	COG2186	Transcriptional regulator
HFS01_RS19150	COG1166	arginine decarboxylase activity
HFS01_RS19175	COG2814	Major facilitator Superfamily
HFS01_RS19185	COG2356	endonuclease I
HFS01_RS19190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFS01_RS19215	COG2805	Type II/IV secretion system protein
HFS01_RS19220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HFS01_RS19225	COG0762	integral membrane protein
HFS01_RS19240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFS01_RS19250	COG0252	asparaginase activity
HFS01_RS19260	COG3171	Protein conserved in bacteria
HFS01_RS19285	COG2211	Major facilitator Superfamily
HFS01_RS19290	COG1982	Orn Lys Arg decarboxylase major
HFS01_RS19295	COG1811	Na channel or pump
HFS01_RS19360	COG0531	amino acid
HFS01_RS19370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFS01_RS19375	COG1012	belongs to the aldehyde dehydrogenase family
HFS01_RS19400	COG2271	Major facilitator Superfamily
HFS01_RS19410	COG0246	Mannitol dehydrogenase
HFS01_RS19425	COG0754	glutathionylspermidine amidase activity
HFS01_RS19430	COG0625	glutathione transferase activity
HFS01_RS19440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFS01_RS19445	COG0298	carbon dioxide binding
HFS01_RS19455	COG1773	rubredoxin
HFS01_RS19460	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HFS01_RS19465	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HFS01_RS19470	COG5557	Pfam Polysulphide reductase, NrfD
HFS01_RS19475	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS19480	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HFS01_RS19490	COG0840	transmembrane signaling receptor activity
HFS01_RS19515	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS19520	COG0848	biopolymer transport protein
HFS01_RS19540	COG2207	Transcriptional regulator
HFS01_RS19545	COG1979	alcohol dehydrogenase
HFS01_RS19555	COG0471	metal ion transport
HFS01_RS19585	COG3039	Transposase
HFS01_RS19605	COG0604	alcohol dehydrogenase
HFS01_RS19675	COG0697	spore germination
HFS01_RS19680	COG1234	tRNA 3'-trailer cleavage
HFS01_RS19690	COG1902	pentaerythritol trinitrate reductase activity
HFS01_RS19695	COG0640	Transcriptional regulator
HFS01_RS19765	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HFS01_RS19770	COG3111	PFAM Bacterial OB fold (BOF) protein
HFS01_RS19780	COG0642	Histidine kinase
HFS01_RS19785	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFS01_RS19790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HFS01_RS19800	COG3150	esterase
HFS01_RS19805	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFS01_RS19810	COG3151	Protein conserved in bacteria
HFS01_RS19815	COG0494	nUDIX hydrolase
HFS01_RS19830	COG0754	glutathionylspermidine amidase activity
HFS01_RS19835	COG3384	dioxygenase
HFS01_RS19875	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFS01_RS19880	COG2268	Band 7 protein
HFS01_RS19900	COG3025	triphosphatase activity
HFS01_RS19905	COG4991	sh3 domain protein
HFS01_RS19920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HFS01_RS19945	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HFS01_RS20015	COG5301	cellulose 1,4-beta-cellobiosidase activity
HFS01_RS20095	COG4695	Portal protein
HFS01_RS20180	COG4974	Belongs to the 'phage' integrase family
HFS01_RS20225	COG3423	Transcriptional regulator
HFS01_RS20230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFS01_RS20245	COG0641	radical SAM
HFS01_RS20295	COG4227	nucleotidyltransferase activity
HFS01_RS20300	COG0494	nUDIX hydrolase
HFS01_RS20320	COG1064	alcohol dehydrogenase
HFS01_RS20325	COG3265	gluconokinase activity
HFS01_RS20330	COG1063	alcohol dehydrogenase
HFS01_RS20335	COG1028	Short-chain dehydrogenase reductase Sdr
HFS01_RS20340	COG2610	gluconate transmembrane transporter activity
HFS01_RS20345	COG1609	Transcriptional regulator
HFS01_RS20350	COG0795	lipopolysaccharide-transporting ATPase activity
HFS01_RS20355	COG0795	lipopolysaccharide-transporting ATPase activity
HFS01_RS20365	COG2927	DNA polymerase III (CHI subunit)
HFS01_RS20405	COG2731	YhcH YjgK YiaL family protein
HFS01_RS20425	COG1288	antiporter activity
HFS01_RS20430	COG1438	arginine binding
HFS01_RS20480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS01_RS20480	COG1263	PTS System
HFS01_RS20485	COG0366	Alpha amylase catalytic
HFS01_RS20500	COG2026	Addiction module toxin, RelE StbE family
HFS01_RS20505	COG3077	Addiction module antitoxin, RelB DinJ family
HFS01_RS20510	COG3711	transcriptional antiterminator
HFS01_RS20510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS20525	COG3964	amidohydrolase
HFS01_RS20560	COG0312	modulator of DNA gyrase
HFS01_RS20570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFS01_RS20585	COG3964	amidohydrolase
HFS01_RS20590	COG2271	Major facilitator Superfamily
HFS01_RS20595	COG2105	PFAM AIG2 family protein
HFS01_RS20615	COG1253	flavin adenine dinucleotide binding
HFS01_RS20625	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HFS01_RS20640	COG1733	regulation of RNA biosynthetic process
HFS01_RS20645	COG0702	epimerase
HFS01_RS20650	COG0697	spore germination
HFS01_RS20660	COG1113	amino acid transport
HFS01_RS20665	COG0545	Peptidyl-prolyl cis-trans isomerase
HFS01_RS20670	COG3061	Opacity-associated protein A
HFS01_RS20685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFS01_RS20705	COG3477	response to acidic pH
HFS01_RS20750	COG1073	alpha beta
HFS01_RS20755	COG3650	response to hydrogen peroxide
HFS01_RS20765	COG1960	acyl-CoA dehydrogenase activity
HFS01_RS20770	COG0754	glutathionylspermidine amidase activity
HFS01_RS20775	COG5463	Belongs to the UPF0441 family
HFS01_RS20780	COG3766	membrane
HFS01_RS20795	COG1842	Phage shock protein A
HFS01_RS20800	COG3789	protein conserved in bacteria
HFS01_RS20810	COG0557	exoribonuclease II activity
HFS01_RS20825	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HFS01_RS20830	COG0330	HflC and HflK could
HFS01_RS20835	COG0330	HflC and HflK could
HFS01_RS20840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFS01_RS20865	COG0802	atpase or kinase
HFS01_RS20870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HFS01_RS20870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HFS01_RS20895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFS01_RS20915	COG1511	domain protein
HFS01_RS20915	COG3264	Mechanosensitive ion channel
HFS01_RS20935	COG1053	succinate dehydrogenase
HFS01_RS20940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFS01_RS20970	COG5510	response to toxic substance
HFS01_RS21010	COG0531	amino acid
HFS01_RS21015	COG3030	protein affecting phage T7 exclusion by the F plasmid
HFS01_RS21020	COG1027	Aspartate ammonia-lyase
HFS01_RS21025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HFS01_RS21040	COG1309	transcriptional regulator
HFS01_RS21075	COG4974	Belongs to the 'phage' integrase family
HFS01_RS21110	COG4735	regulation of single-species biofilm formation
HFS01_RS21115	COG2378	regulation of single-species biofilm formation
HFS01_RS21170	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HFS01_RS21170	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HFS01_RS21175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFS01_RS21180	COG1063	alcohol dehydrogenase
HFS01_RS21185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFS01_RS21190	COG1063	alcohol dehydrogenase
HFS01_RS21195	COG3716	PTS system mannose fructose sorbose family IID component
HFS01_RS21205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS01_RS21210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFS01_RS21210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFS01_RS21220	COG3039	Transposase
HFS01_RS21225	COG0671	phosphoesterase, PA-phosphatase related
HFS01_RS21250	COG2197	response regulator
HFS01_RS21255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFS01_RS21280	COG3381	protein complex oligomerization
HFS01_RS21285	COG3302	dmso reductase anchor subunit
HFS01_RS21290	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS21295	COG0243	molybdopterin cofactor binding
HFS01_RS21300	COG3290	protein histidine kinase activity
HFS01_RS21305	COG4565	transcriptional regulatory protein
HFS01_RS21315	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HFS01_RS21320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS01_RS21320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFS01_RS21335	COG2169	Transcriptional regulator
HFS01_RS21340	COG1982	Orn Lys Arg decarboxylase major
HFS01_RS21345	COG2207	Transcriptional regulator
HFS01_RS21350	COG0531	amino acid
HFS01_RS21380	COG2824	Alkylphosphonate utilization operon protein PhnA
HFS01_RS21385	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HFS01_RS21405	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HFS01_RS21410	COG1301	dicarboxylic acid transport
HFS01_RS21415	COG4235	cytochrome complex assembly
HFS01_RS21420	COG3088	subunit of a heme lyase
HFS01_RS21425	COG1138	Cytochrome C-type biogenesis protein
HFS01_RS21430	COG3301	Polysulphide reductase, NrfD
HFS01_RS21435	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS21440	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HFS01_RS21450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFS01_RS21455	COG3162	membrane
HFS01_RS21465	COG1346	cytolysis
HFS01_RS21470	COG1380	Effector of murein hydrolase LrgA
HFS01_RS21475	COG0583	DNA-binding transcription factor activity
HFS01_RS21480	COG0025	NhaP-type Na H and K H
HFS01_RS21485	COG2252	PERMEase
HFS01_RS21505	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HFS01_RS21565	COG2315	Protein conserved in bacteria
HFS01_RS21615	COG0735	belongs to the Fur family
HFS01_RS21630	COG0534	Mate efflux family protein
HFS01_RS21640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HFS01_RS21685	COG3833	ABC-type maltose transport systems, permease component
HFS01_RS21695	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFS01_RS21720	COG0527	aspartate kinase activity
HFS01_RS21800	COG2246	polysaccharide biosynthetic process
HFS01_RS21830	COG5301	cellulose 1,4-beta-cellobiosidase activity
HFS01_RS21835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HFS01_RS21870	COG3122	Protein conserved in bacteria
HFS01_RS21915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFS01_RS21955	COG0151	Belongs to the GarS family
HFS01_RS22020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFS01_RS22025	COG2104	thiamine diphosphate biosynthetic process
HFS01_RS22085	COG0250	Participates in transcription elongation, termination and antitermination
HFS01_RS22135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HFS01_RS22195	COG0583	DNA-binding transcription factor activity
HFS01_RS22230	COG2207	Transcriptional regulator
HFS01_RS22240	COG0371	Dehydrogenase
HFS01_RS22245	COG3738	Protein conserved in bacteria
HFS01_RS22260	COG0737	Belongs to the 5'-nucleotidase family
HFS01_RS22275	COG0668	transmembrane transport
HFS01_RS22280	COG0527	aspartate kinase activity
HFS01_RS22280	COG0460	homoserine dehydrogenase
HFS01_RS22285	COG0626	cystathionine gamma-synthase activity
HFS01_RS22305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFS01_RS22310	COG1609	Transcriptional regulator
HFS01_RS22315	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HFS01_RS22330	COG1575	Belongs to the MenA family. Type 1 subfamily
HFS01_RS22345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HFS01_RS22355	COG1494	fructose-1,6-bisphosphatase
HFS01_RS22365	COG3152	Membrane
HFS01_RS22420	COG1070	Carbohydrate kinase
HFS01_RS22440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFS01_RS22455	COG2211	Major facilitator Superfamily
HFS01_RS22480	COG3678	ATP-independent chaperone mediated protein folding
HFS01_RS22485	COG0745	RESPONSE REGULATOR receiver
HFS01_RS22490	COG2205	protein histidine kinase activity
HFS01_RS22505	COG2258	MOSC domain
HFS01_RS22510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFS01_RS22520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HFS01_RS22565	COG1454	alcohol dehydrogenase
HFS01_RS22580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFS01_RS22610	COG0437	4 iron, 4 sulfur cluster binding
HFS01_RS22615	COG2864	formate dehydrogenase
HFS01_RS22630	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HFS01_RS22640	COG4680	protein conserved in bacteria
HFS01_RS22645	COG5499	transcription regulator containing HTH domain
HFS01_RS22650	COG0456	acetyltransferase
HFS01_RS22665	COG1011	Hydrolase
HFS01_RS22670	COG1349	DNA-binding transcription factor activity
HFS01_RS22675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS22685	COG3684	Belongs to the aldolase LacD family
HFS01_RS22695	COG2017	converts alpha-aldose to the beta-anomer
HFS01_RS22700	COG1501	Belongs to the glycosyl hydrolase 31 family
HFS01_RS22745	COG0561	phosphatase activity
HFS01_RS22800	COG0204	Acyl-transferase
HFS01_RS22815	COG3084	Protein conserved in bacteria
HFS01_RS22820	COG0746	molybdenum cofactor guanylyltransferase activity
HFS01_RS22825	COG1763	Mo-molybdopterin cofactor biosynthetic process
HFS01_RS22865	COG1739	Uncharacterized protein family UPF0029
HFS01_RS22895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HFS01_RS22910	COG0805	protein transport
HFS01_RS22955	COG0641	radical SAM
HFS01_RS22975	COG0561	phosphatase activity
HFS01_RS22980	COG2267	carboxylic ester hydrolase activity
HFS01_RS22985	COG1280	lysine exporter protein (LysE YggA)
HFS01_RS22990	COG1280	lysine exporter protein (LysE YggA)
HFS01_RS23035	COG1011	Hydrolase
HFS01_RS23110	COG2959	enzyme of heme biosynthesis
HFS01_RS23115	COG3071	HemY protein
HFS01_RS23160	COG2244	polysaccharide biosynthetic process
HFS01_RS23165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HFS01_RS23170	COG0456	acetyltransferase
HFS01_RS23175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HFS01_RS23175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HFS01_RS23180	COG1088	dTDP-glucose 4,6-dehydratase activity
HFS01_RS23185	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HFS01_RS23215	COG3118	belongs to the thioredoxin family
HFS01_RS23290	COG3978	acetolactate synthase activity
HFS01_RS23355	COG2186	Transcriptional regulator
HFS01_RS23360	COG0477	Major facilitator Superfamily
HFS01_RS23365	COG1609	Transcriptional regulator
HFS01_RS23370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFS01_RS23380	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFS01_RS23415	COG1522	sequence-specific DNA binding
HFS01_RS23420	COG0716	FMN binding
HFS01_RS23435	COG3312	ion transport
HFS01_RS23495	COG4533	DNA binding
HFS01_RS23500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HFS01_RS23505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFS01_RS23505	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFS01_RS23505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFS01_RS23510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFS01_RS23515	COG0573	inorganic phosphate transmembrane transporter activity
HFS01_RS23520	COG0581	inorganic phosphate transmembrane transporter activity
HFS01_RS23530	COG0704	Plays a role in the regulation of phosphate uptake
HFS01_RS23535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFS01_RS23545	COG2252	PERMEase
HFS01_RS23550	COG0431	NADPH-dependent FMN reductase
HFS01_RS23555	COG2091	lysine biosynthetic process via aminoadipic acid
HFS01_RS23630	COG4974	Belongs to the 'phage' integrase family
HFS01_RS23650	COG2801	Transposase and inactivated derivatives
HFS01_RS23680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFS01_RS23685	COG0501	Belongs to the peptidase M48B family
HFS01_RS23740	COG0542	response to heat
HFS01_RS23745	COG0071	Belongs to the small heat shock protein (HSP20) family
HFS01_RS23775	COG2826	transposase and inactivated derivatives, IS30 family
HFS01_RS23845	COG3300	MHYT domain
HFS01_RS23845	COG5001	Diguanylate cyclase
HFS01_RS23905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFS01_RS23970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFS01_RS24025	COG2205	protein histidine kinase activity
HFS01_RS24030	COG0745	RESPONSE REGULATOR receiver
HFS01_RS24035	COG1276	copper resistance
HFS01_RS24040	COG2372	response to copper ion
HFS01_RS24045	COG3667	copper resistance
HFS01_RS24050	COG2132	Multicopper oxidase
HFS01_RS24060	COG0739	heme binding
HFS01_RS24090	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family