locus-tag class description GH768_RS00010 ENOG4107QX9 Thiol disulfide interChange protein GH768_RS00015 ENOG4105DA4 cytochrome c-type biogenesis protein GH768_RS00025 ENOG4105X3C heme exporter protein GH768_RS00030 ENOG41060IM Heme exporter protein GH768_RS00035 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GH768_RS00040 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GH768_RS00045 ENOG4105CUW cytochrome C-TYPE protein GH768_RS00050 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) GH768_RS00055 ENOG4105GXZ Ferredoxin-type protein NapH GH768_RS00060 ENOG4108BGM Quinol dehydrogenase periplasmic component GH768_RS00070 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase GH768_RS00075 ENOG4108ZNS ferredoxin-type protein NapF GH768_RS00085 ENOG4105CHH sulfate transporter GH768_RS00090 ENOG4105IBP Cyclic peptide transporter GH768_RS00095 ENOG4105CF1 Alkylated DNA repair protein GH768_RS00100 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GH768_RS00105 ENOG4105CJ2 (LipO)protein GH768_RS00110 ENOG4105FCK Membrane GH768_RS00115 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GH768_RS00120 ENOG41068CG regulatoR GH768_RS00125 ENOG4105BZU Histidine kinase GH768_RS00130 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH768_RS00135 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GH768_RS00140 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GH768_RS00145 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GH768_RS00150 ENOG4105XPH Ferredoxin GH768_RS00155 ENOG4105CZM Major Facilitator GH768_RS00160 ENOG4105GZI Transcriptional regulator GH768_RS00165 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GH768_RS00170 ENOG4105CXY transporter GH768_RS00175 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GH768_RS00185 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GH768_RS00195 ENOG4108EWA cinA-like protein GH768_RS00200 ENOG4108UII YfaZ family GH768_RS00250 ENOG4106GZG polymyxin resistance protein B GH768_RS00255 ENOG4105CEY Amp-dependent synthetase and ligase GH768_RS00265 ENOG4108IPT Naphthoate synthase GH768_RS00280 ENOG4105E4F Isochorismate synthase GH768_RS00285 ENOG4105TNS Conserved Protein GH768_RS00290 ENOG4107YB6 acetyltransferase, (GNAT) family GH768_RS00310 ENOG4105C8S subunit m GH768_RS00315 ENOG4105D65 subunit l GH768_RS00325 ENOG4107UFS subunit j GH768_RS00335 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GH768_RS00340 ENOG4108IEH NADH dehydrogenase subunit g GH768_RS00345 ENOG4107QIZ NADH dehydrogenase GH768_RS00350 ENOG4105GKE subunit e GH768_RS00360 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GH768_RS00365 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GH768_RS00375 ENOG4107NQ8 LysR family Transcriptional regulator GH768_RS00380 ENOG4105CHM Aminotransferase GH768_RS00390 ENOG4107QWE )-transporter GH768_RS00395 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GH768_RS00410 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GH768_RS00415 ENOG4105C6K Malic enzyme GH768_RS00420 ENOG4105CSX c4-dicarboxylate anaerobic carrier GH768_RS00425 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GH768_RS00430 ENOG4108HHA Transketolase GH768_RS00435 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GH768_RS00445 ENOG4106ETB IIa component GH768_RS00450 ENOG4105K2J Transcriptional regulator GH768_RS00455 ENOG4105PTV Nudix Hydrolase GH768_RS00460 ENOG4108RE9 Phosphodiesterase GH768_RS00465 ENOG4108SHQ Glutathione S-transferase GH768_RS00470 ENOG4105CYM Glutathione S-transferase GH768_RS00475 ENOG4105ECP epimerase GH768_RS00480 ENOG4108JEH abc transporter atp-binding protein GH768_RS00485 ENOG4106YG3 ABC transporter GH768_RS00490 ENOG4105DSP amino acid AbC transporter GH768_RS00495 ENOG4105E89 ABC transporter GH768_RS00500 ENOG4105E89 ABC transporter GH768_RS00505 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GH768_RS00515 ENOG4106M28 alanine racemase domain protein GH768_RS00520 ENOG4105E5D amino acid GH768_RS00530 ENOG4108JUB Transcriptional regulator GH768_RS00535 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GH768_RS00540 ENOG4105E96 Colicin v production protein GH768_RS00545 ENOG4108S3P Sporulation domain protein GH768_RS00550 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GH768_RS00560 ENOG4105DQR SNARE associated Golgi GH768_RS00570 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GH768_RS00580 ENOG4106WZ1 flagella biosynthesis regulator GH768_RS00595 ENOG4105R8V Transcriptional regulator GH768_RS00610 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GH768_RS00615 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GH768_RS00620 ENOG4105MH2 YfcL protein GH768_RS00625 ENOG4108BPE -transporting atpase GH768_RS00630 ENOG4105EJ9 Membrane GH768_RS00635 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) GH768_RS00645 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GH768_RS00655 ENOG4108BY2 phosphohistidine phosphatase GH768_RS00670 ENOG4105KZW UPF0381 protein GH768_RS00675 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GH768_RS00680 ENOG410903C (LipO)protein GH768_RS00685 ENOG4105S64 Formate nitrite transporter GH768_RS00705 ENOG4108NC2 Outer membrane protease GH768_RS00710 ENOG4105W9M Membrane GH768_RS00715 ENOG4105D1S lipid A biosynthesis GH768_RS00725 ENOG4105CHM Aminotransferase GH768_RS00730 ENOG4108CIP transcriptional regulator GH768_RS00735 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GH768_RS00740 ENOG4105CN9 Peptidase m42 family protein GH768_RS00745 ENOG4105DC7 peptidase M24 GH768_RS00750 ENOG410863U PTS System GH768_RS00755 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GH768_RS00770 ENOG4107RA9 decarboxylase GH768_RS00775 ENOG4105CPC Aldo Keto reductase GH768_RS00780 ENOG4109076 Conserved Protein GH768_RS00790 ENOG4105D9N nucleoside GH768_RS00795 ENOG4108KMM Diguanylate cyclase GH768_RS00810 ENOG4105HZG regulatoR GH768_RS00815 ENOG4105GXM Putative transcription regulator (DUF1323) GH768_RS00850 ENOG4105CS6 Rhs element vgr protein GH768_RS00855 ENOG4105CNA YD repeat protein GH768_RS00880 ENOG4108M0I Transcriptional regulator GH768_RS00885 ENOG4105DHU Bile acid GH768_RS00890 ENOG4105VRT cytoplasmic protein GH768_RS00910 ENOG4105C6T cysteine synthase GH768_RS00925 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GH768_RS00930 ENOG4105C5Y PTS System GH768_RS00940 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GH768_RS00945 ENOG4105CSW GntR family transcriptional regulator GH768_RS00950 ENOG41089BK Glutamine amido-transferase GH768_RS00955 ENOG4105C6T cysteine synthase GH768_RS00960 ENOG4108IJ6 ABC transporter GH768_RS00965 ENOG4105ECW sulfate abc transporter GH768_RS00970 ENOG4108I5D sulfate abc transporter GH768_RS00975 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GH768_RS00980 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GH768_RS00985 ENOG4105EZR dyp-type peroxidase family protein GH768_RS00990 ENOG4105E7K (LipO)protein GH768_RS00995 ENOG4105QZU Inner membrane protein YfeZ GH768_RS01000 ENOG4108R6G acetyltransferase GH768_RS01005 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase GH768_RS01015 ENOG4108K3Z AraC family transcriptional regulator GH768_RS01020 ENOG4108X49 Ethanolamine utilization protein EutK GH768_RS01025 ENOG4106D67 ethanolamine utilization protein GH768_RS01035 ENOG4105CPD ethanolamine ammonia-lyase GH768_RS01040 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase GH768_RS01045 ENOG4105ENY Ethanolamine utilization protein eutH GH768_RS01050 ENOG4105C0A alcohol dehydrogenase GH768_RS01055 ENOG4107YMV ethanolamine utilization protein GH768_RS01060 ENOG4108EKI Dehydrogenase GH768_RS01065 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml GH768_RS01070 ENOG4105KNY Microcompartments protein GH768_RS01075 ENOG4108IJ2 phosphate acetyltransferase GH768_RS01080 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase GH768_RS01085 ENOG4105NDK ethanolamine utilization protein GH768_RS01090 ENOG4106S4J ethanolamine utilization protein EutP GH768_RS01095 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place GH768_RS01100 ENOG4105C4X radical SAM domain protein GH768_RS01105 ENOG4105ENH Sulfatase GH768_RS01110 ENOG4105C6K Malic enzyme GH768_RS01120 ENOG4105CV1 Transketolase (EC 2.2.1.1) GH768_RS01130 ENOG4108PVD exported protein GH768_RS01135 ENOG4107VIJ nudix hydrolase GH768_RS01140 ENOG4107S1E Beta-lactamase GH768_RS01145 ENOG4105BZ8 glutamate synthase GH768_RS01150 ENOG4105BZU Histidine kinase GH768_RS01155 ENOG4105BZS acriflavin resistance protein GH768_RS01165 ENOG4105KUZ arsenate reductase GH768_RS01170 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GH768_RS01180 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GH768_RS01185 ENOG4105CGZ zinc metallopeptidase GH768_RS01195 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GH768_RS01200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH768_RS01205 ENOG4105RH4 Glycine cleavage system transcriptional repressor GH768_RS01210 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GH768_RS01215 ENOG4105BZW Glycerate kinase GH768_RS01220 ENOG4107QQ0 gntp family GH768_RS01225 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GH768_RS01230 ENOG4105C02 permease GH768_RS01235 ENOG4105ERG peptidase m48, ste24p GH768_RS01240 ENOG4105K89 arsenate reductase GH768_RS01245 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) GH768_RS01250 ENOG4105C2W permease GH768_RS01255 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GH768_RS01265 ENOG4108V3E phosphoribosylglycinamide formyltransferase GH768_RS01270 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GH768_RS01275 ENOG4105C9X ppx gppa phosphatase GH768_RS01280 ENOG4105BZU Histidine kinase GH768_RS01290 ENOG41062G3 Protein of unknown function (DUF2633) GH768_RS01295 ENOG4108ZMA Outer membrane lipoprotein GH768_RS01300 ENOG41066DY Membrane GH768_RS01335 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GH768_RS01340 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GH768_RS01345 ENOG4105D4Y metalloprotease GH768_RS01355 ENOG4105VPD cellular component movement GH768_RS01365 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GH768_RS01370 ENOG4105N21 Membrane GH768_RS01390 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GH768_RS01395 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GH768_RS01410 ENOG4105QAX Iron-sulfur GH768_RS01415 ENOG4107QY8 reductase GH768_RS01420 ENOG4108JQB penicillin-binding protein 1C GH768_RS01430 ENOG4105KHC sulfurtransferase GH768_RS01435 ENOG4105YYA enhanced serine sensitivity protein SseB GH768_RS01445 ENOG4105WVQ Fe-S assembly protein IscX GH768_RS01450 ENOG4108ZIT Ferredoxin, 2FE-2S GH768_RS01455 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GH768_RS01460 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) GH768_RS01465 ENOG4108Z4V iron-sulfur cluster assembly GH768_RS01470 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GH768_RS01485 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GH768_RS01490 ENOG4105ECY inositol monophosphatase GH768_RS01495 ENOG4105D5B Sulfite reductase, subunit A GH768_RS01500 ENOG4107SHJ sulfite reductase subunit b GH768_RS01505 ENOG410810Y Sulfite reductase GH768_RS01510 ENOG4105D7X high-affinity nickel-transporter GH768_RS01520 ENOG4108MN2 Stationary phase inducible protein CsiE GH768_RS01525 ENOG4105D8G Major Facilitator superfamily GH768_RS01540 ENOG4108M3R transcriptional activator CadC GH768_RS01545 ENOG4105D5Q Arginine ornithine antiporter GH768_RS01550 ENOG4105CXN decarboxylase GH768_RS01555 ENOG4105DUX Transporter GH768_RS01565 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH768_RS01570 ENOG4108SKK alpha helix protein GH768_RS01575 ENOG4107WP9 Histidine kinase GH768_RS01580 ENOG4108ETH Formylglycinamide ribotide synthetase GH768_RS01590 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GH768_RS01595 ENOG4108Z6B deaminase GH768_RS01600 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB GH768_RS01610 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GH768_RS01615 ENOG4106G6Q Transcriptional regulator GH768_RS01620 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GH768_RS01650 ENOG4105C3F Signal peptidase i GH768_RS01660 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GH768_RS01685 ENOG4108IYU L-aspartate oxidase GH768_RS01695 ENOG4105C1J atp-dependent rna helicase GH768_RS01700 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) GH768_RS01710 ENOG4105EIB trna rrna methyltransferase GH768_RS01715 ENOG4105K63 Thioredoxin GH768_RS01720 ENOG4106IUH DTW domain containing protein GH768_RS01725 ENOG4105CD5 CoA-binding domain protein GH768_RS01730 ENOG4105JIM Phosphatidylserine synthase GH768_RS01735 ENOG4105T42 (LipO)protein GH768_RS01740 ENOG4105CSH Transporter GH768_RS01770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GH768_RS01775 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GH768_RS01780 ENOG4105C34 Pseudouridine synthase GH768_RS01785 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GH768_RS01790 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GH768_RS01815 ENOG4105UZW Tail fiber assembly protein GH768_RS01820 ENOG4108X9F tail fiber protein GH768_RS01915 ENOG4105ED4 portal protein GH768_RS01955 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH768_RS01965 ENOG4105CQC Prephenate dehydratase GH768_RS01975 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GH768_RS01980 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GH768_RS01985 ENOG4108WS1 GH768_RS01990 ENOG4108KHX Diguanylate cyclase GH768_RS01995 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GH768_RS02015 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GH768_RS02020 ENOG4106KVJ cytochrome C assembly protein GH768_RS02025 ENOG4108JU6 CBS domain protein GH768_RS02040 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GH768_RS02045 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GH768_RS02055 ENOG4108Z1B Cyclase dehydrase GH768_RS02075 ENOG4105BZ1 (ABC) transporter GH768_RS02090 ENOG4105DFP Integrase GH768_RS02205 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GH768_RS02210 ENOG4105UZW Tail fiber assembly protein GH768_RS02230 ENOG4105NIV Esterase GH768_RS02235 ENOG4107RNH Outer membrane receptor FepA GH768_RS02245 ENOG4108MJ5 VirK protein GH768_RS02255 ENOG4105DHQ Histidine kinase GH768_RS02285 ENOG4105D5U fad dependent oxidoreductase GH768_RS02290 ENOG4105C26 Dehydrogenase GH768_RS02295 ENOG4108JPW Aminotransferase GH768_RS02300 ENOG4105C85 amino acid GH768_RS02305 ENOG4108PVQ transcriptional regulator GH768_RS02310 ENOG4109066 lysm domain bon superfamily protein GH768_RS02315 ENOG4105VPI YqaE family transport protein GH768_RS02320 ENOG41080HT Transcriptional regulator, arsr family GH768_RS02325 ENOG4108V62 Rhodanese domain protein GH768_RS02335 ENOG4108X73 DNA- binding protein GH768_RS02340 ENOG4108RNS Exports L-alanine (By similarity) GH768_RS02345 ENOG4108WMJ Protein of unknown function (DUF2002) GH768_RS02350 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) GH768_RS02355 ENOG4105WAZ (Glutaredoxin-like protein) NrdH GH768_RS02360 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GH768_RS02365 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GH768_RS02370 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GH768_RS02375 ENOG4108IJ7 Glycine betaine GH768_RS02380 ENOG4108HQS Glycine betaine GH768_RS02385 ENOG4105GIJ Glycine betaine GH768_RS02395 ENOG4105NTK Transcriptional repressor Mpra GH768_RS02400 ENOG4105CW7 secretion protein, HlyD family GH768_RS02405 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH768_RS02410 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GH768_RS02415 ENOG4105D9M gamma-glutamylcysteine synthetase GH768_RS02420 ENOG4105W39 Membrane GH768_RS02425 ENOG4107VXZ Hydrolase GH768_RS02455 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GH768_RS02460 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GH768_RS02475 ENOG4107TH8 cina domain protein GH768_RS02480 ENOG4105CVE Lytic murein transglycosylase GH768_RS02485 ENOG410787A Pts system, glucitol sorbitol-specific GH768_RS02490 ENOG4105DZY Pts system, glucitol sorbitol-specific GH768_RS02495 ENOG4105VI0 Pts system, glucitol sorbitol-specific GH768_RS02500 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase GH768_RS02505 ENOG4105J92 DNA-binding transcriptional activator GutM GH768_RS02510 ENOG410804X Transcriptional regulator GH768_RS02515 ENOG4105C2X Arabinose 5-phosphate isomerase GH768_RS02525 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center GH768_RS02535 ENOG4105C8H hydrogenase maturation protein Hypf GH768_RS02540 ENOG4108RC0 Electron transport protein GH768_RS02545 ENOG4108MG9 hydrogenase 3 maturation protease GH768_RS02550 ENOG4105I6X formate hydrogenlyase maturation GH768_RS02555 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit GH768_RS02560 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit GH768_RS02565 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GH768_RS02570 ENOG4107TDF Formate hydrogenlyase subunit 4 GH768_RS02575 ENOG4107R30 NADH dehydrogenase GH768_RS02580 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) GH768_RS02585 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA GH768_RS02590 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GH768_RS02595 ENOG4107RSS Hydrogenase accessory protein HypB GH768_RS02600 ENOG41083WG hydrogenase assembly chaperone GH768_RS02605 ENOG4105CQS hydrogenase expression formation protein HypD GH768_RS02610 ENOG4105C45 hydrogenase expression formation protein (HypE) GH768_RS02620 ENOG4105VXR cytoplasmic protein GH768_RS02630 ENOG4105DIK (ABC) transporter GH768_RS02635 ENOG4105CC5 ABC transporter GH768_RS02640 ENOG4105CC5 ABC transporter GH768_RS02670 ENOG4108RBT type iii secretion GH768_RS02675 ENOG4106BTR GH768_RS02680 ENOG4105Y7Q type iii secretion GH768_RS02685 ENOG4108RC9 Type III secretion system protein GH768_RS02695 ENOG4108YAB Invasion protein GH768_RS02700 ENOG4105FTC Lytic transglycosylase catalytic GH768_RS02705 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear GH768_RS02720 ENOG41079WB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GH768_RS02730 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC GH768_RS02740 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE GH768_RS02750 ENOG4108M6W surface presentation of antigens protein SpaS GH768_RS02755 ENOG4108TN6 type iii secretion GH768_RS02760 ENOG4105U07 type iii secretion GH768_RS02765 ENOG41075IY surface presentation of antigens protein SpaP GH768_RS02770 ENOG4105T85 surface presentation of antigens protein GH768_RS02775 ENOG41078G4 surface presentation of GH768_RS02780 ENOG41077MC Secretory protein (Associated with virulence) GH768_RS02785 ENOG4108JIR Flagellum-specific ATP synthase GH768_RS02790 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone GH768_RS02795 ENOG4108HR8 type iii secretion GH768_RS02800 ENOG4108N8R Invasion protein GH768_RS02810 ENOG41090HZ type iii secretion GH768_RS02830 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH768_RS02835 ENOG4105JQN Transcriptional regulator GH768_RS02840 ENOG4105C6Z Gluconate GH768_RS02845 ENOG4105EXW epimerase dehydratase GH768_RS02850 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GH768_RS02860 ENOG4105G63 Type III effector Hrp-dependent GH768_RS02870 ENOG4105MVE transcriptional regulator GH768_RS02880 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GH768_RS02885 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GH768_RS02890 ENOG4105KZM cytoplasmic protein GH768_RS02900 ENOG4108K5P (LipO)protein GH768_RS02935 ENOG4105N0Z inner membrane protein ygbE GH768_RS02955 ENOG4108MXK alkaline phosphatase isozyme conversion GH768_RS02970 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GH768_RS02980 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GH768_RS02985 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GH768_RS02990 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GH768_RS03015 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GH768_RS03025 ENOG4105DXN mazG family GH768_RS03030 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GH768_RS03040 ENOG4105BZU Histidine kinase GH768_RS03050 ENOG4105QDK Flavodoxin GH768_RS03055 ENOG4105DR9 pseudouridine synthase GH768_RS03060 ENOG4105WP7 tRNA pseudouridine synthase C GH768_RS03075 ENOG4105EWT decarboxylase family GH768_RS03080 ENOG4105C44 Serine transporter GH768_RS03085 ENOG4105EJQ L-serine dehydratase GH768_RS03095 ENOG4105C0A alcohol dehydrogenase GH768_RS03100 ENOG4107W7X Aldolase GH768_RS03105 ENOG4105EDR glucose galactose transporter GH768_RS03115 ENOG4105CMG Carbohydrate kinase GH768_RS03125 ENOG4107EDW L-fucose operon activator GH768_RS03135 ENOG4105M08 Membrane GH768_RS03140 ENOG4105ETT transcriptional Regulator, LysR family GH768_RS03145 ENOG4105M5B (LipO)protein GH768_RS03150 ENOG4105C9B Cysteine desulfurase GH768_RS03155 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GH768_RS03160 ENOG4105FR1 rard protein GH768_RS03165 ENOG4105CUZ uba thif-type nad fad binding protein GH768_RS03170 ENOG4105CA3 membrane-bound lytic murein transglycosylase GH768_RS03185 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GH768_RS03190 ENOG4108EKC n-acetylglutamate synthase GH768_RS03195 ENOG4107QYX exodeoxyribonuclease v alpha GH768_RS03200 ENOG4107QKA exodeoxyribonuclease V beta GH768_RS03205 ENOG4107QXK peptidase GH768_RS03210 ENOG4105DSY exodeoxyribonuclease V, gamma GH768_RS03215 ENOG4105RVB Prepilin peptidase dependent protein c GH768_RS03220 ENOG4105SEN Protein of unknown function (DUF2509) GH768_RS03225 ENOG4105JCS prepilin peptidase dependent protein GH768_RS03230 ENOG4105IPU prepilin peptidase dependent protein A GH768_RS03245 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GH768_RS03250 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GH768_RS03260 ENOG4105EE5 Membrane protein terC GH768_RS03265 ENOG4105SUV lipoprotein YgdR GH768_RS03270 ENOG4105CPC Aldo Keto reductase GH768_RS03275 ENOG4107S74 Lysophospholipid transporter LplT GH768_RS03290 ENOG4105DDV Transcriptional regulator (LacI family GH768_RS03300 ENOG4105RQF LysR family Transcriptional regulator GH768_RS03310 ENOG4107QNK )-transporter GH768_RS03315 ENOG4105CHR reductase GH768_RS03325 ENOG4105CHU acetyl-coa acetyltransferase GH768_RS03330 ENOG4105C5Q Transcriptional regulator GH768_RS03340 ENOG4108MHD transport protein GH768_RS03350 ENOG4106PHM regulatory protein GH768_RS03385 ENOG4108K5P (LipO)protein GH768_RS03405 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GH768_RS03410 ENOG4105T95 Thiol disulfide interChange protein GH768_RS03415 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH768_RS03420 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GH768_RS03425 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB GH768_RS03440 ENOG4108UT2 hemolysin iii GH768_RS03450 ENOG4105CS2 ec 3.2.1.21 GH768_RS03455 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GH768_RS03465 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GH768_RS03470 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GH768_RS03475 ENOG4105D0A hydroxylase GH768_RS03480 ENOG4107RAQ aminopeptidase GH768_RS03500 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GH768_RS03505 ENOG4108JQ1 Dehydrogenase GH768_RS03510 ENOG4105E66 phosphoriboisomerase A GH768_RS03520 ENOG4105D5P Methylmalonyl-coA mutase GH768_RS03525 ENOG4105DJT lAO AO transport system ATPase GH768_RS03530 ENOG4108M7F enoyl-CoA hydratase isomerase GH768_RS03535 ENOG4105CYC Transferase GH768_RS03540 ENOG4105DEQ transcriptional regulator GH768_RS03545 ENOG4105MPN Membrane GH768_RS03555 ENOG4105D64 Mechanosensitive ion channel GH768_RS03560 ENOG4105D2N Aldolase GH768_RS03565 ENOG4105BZA Phosphoglycerate kinase GH768_RS03590 ENOG4108JJB ABC transporter GH768_RS03595 ENOG4108JJB ABC transporter GH768_RS03600 ENOG4107Z1W Fructose transport system kinase GH768_RS03605 ENOG4105CV1 Transketolase (EC 2.2.1.1) GH768_RS03610 ENOG4108K0D peptidase, M48 GH768_RS03620 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GH768_RS03635 ENOG4107QNK )-transporter GH768_RS03645 ENOG4105RWS endonuclease I GH768_RS03650 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GH768_RS03655 ENOG4105D7Z glutathione synthase GH768_RS03675 ENOG4105CZX twitching motility protein GH768_RS03680 ENOG4105DFA alanine racemase domain protein GH768_RS03685 ENOG4108VIA integral membrane protein GH768_RS03700 ENOG4105CSA Coproporphyrinogen iii oxidase GH768_RS03705 ENOG4105HDK L-asparaginase GH768_RS03710 ENOG4105K33 Periplasmic Protein GH768_RS03715 ENOG41090ED Protein with unknown function (DUF469) GH768_RS03725 ENOG4105CEN a g-specific adenine glycosylase GH768_RS03730 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GH768_RS03745 ENOG4105CXN decarboxylase GH768_RS03750 ENOG4108UQV Membrane GH768_RS03770 ENOG4108WC9 type VI secretion system effector, hcp1 family GH768_RS03775 ENOG4105CS6 Rhs element vgr protein GH768_RS03800 ENOG4105CYC Transferase GH768_RS03805 ENOG4105DJG MaoC domain protein dehydratase GH768_RS03820 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GH768_RS03830 ENOG4108UAJ Transcriptional regulator GH768_RS03840 ENOG4105CUB amino acid GH768_RS03850 ENOG4105CJP fad dependent oxidoreductase GH768_RS03855 ENOG4105C26 Dehydrogenase GH768_RS03870 ENOG4105DPW Major facilitator superfamily MFS_1 GH768_RS03880 ENOG4105DEI Mannitol dehydrogenase GH768_RS03895 ENOG4105E4I Glycoside hydrolase family 28 GH768_RS03900 ENOG4105CT4 transporter GH768_RS03910 ENOG4106032 Glutathionylspermidine synthase GH768_RS03915 ENOG4105CYM Glutathione S-transferase GH768_RS03920 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein GH768_RS03925 ENOG4105S10 periplasmic binding protein GH768_RS03930 ENOG41082MF Hydrogenase assembly chaperone hypC hupF GH768_RS03935 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GH768_RS03940 ENOG4108WGS hydrogenase 2-specific chaperone GH768_RS03945 ENOG4108USZ hydrogenase GH768_RS03950 ENOG4105DPX Hydrogenase, large subunit GH768_RS03955 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit GH768_RS03960 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GH768_RS03965 ENOG4105E3S small subunit GH768_RS03970 ENOG410900S Protein of unknown function (DUF2623) GH768_RS03975 ENOG4105C8Q Methyl-accepting chemotaxis GH768_RS04000 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GH768_RS04005 ENOG4108ZZF transport protein (ExbD) GH768_RS04010 ENOG4105CWK Biopolymer transport protein, ExbB GH768_RS04015 ENOG4105C28 cystathionine GH768_RS04020 ENOG4108K81 inner membrane protein YghB GH768_RS04025 ENOG4105CF7 AraC family transcriptional regulator GH768_RS04030 ENOG4108I6A alcohol dehydrogenase GH768_RS04035 ENOG4105CV8 reductase GH768_RS04040 ENOG4107QPK )-transporter GH768_RS04050 ENOG4105CCT upf0313 protein GH768_RS04055 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) GH768_RS04060 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GH768_RS04065 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH768_RS04070 ENOG4105GMB type VI secretion system effector, hcp1 family GH768_RS04100 ENOG4105H4F exported protein GH768_RS04105 ENOG4105XJC Two component transcriptional regulator (Winged helix family GH768_RS04110 ENOG4105DHQ Histidine kinase GH768_RS04115 ENOG4105NF4 modulator of drug activity GH768_RS04120 ENOG4105VRH Antibiotic biosynthesis monooxygenase GH768_RS04125 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH768_RS04130 ENOG4105IPS esterase GH768_RS04135 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GH768_RS04140 ENOG4108SX3 cytoplasmic protein GH768_RS04145 ENOG41087AY ADP-Ribose pyrophosphatase GH768_RS04155 ENOG4105F1G UPF0441 protein GH768_RS04160 ENOG4106032 Glutathionylspermidine synthase GH768_RS04165 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GH768_RS04175 ENOG4108MR7 Arylsulfotransferase GH768_RS04185 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) GH768_RS04195 ENOG4105W0Z cytoplasmic protein GH768_RS04215 ENOG4105I7R Adenylate cyclase GH768_RS04220 ENOG4106MWK domain protein GH768_RS04235 ENOG4107ZVW dihydroneopterin aldolase GH768_RS04245 ENOG4105EJC lysr family transcriptional regulator GH768_RS04250 ENOG4106DSS Tartrate dehydratase subunit alpha GH768_RS04255 ENOG4107GFK fumarate GH768_RS04260 ENOG4107QPK )-transporter GH768_RS04275 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GH768_RS04280 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH768_RS04285 ENOG4108VCA G U mismatch-specific DNA glycosylase GH768_RS04300 ENOG4105Q26 Siderophore-interacting protein GH768_RS04305 ENOG4105NTW Transcriptional regulator GH768_RS04310 ENOG4105C8Q Methyl-accepting chemotaxis GH768_RS04315 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GH768_RS04325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GH768_RS04335 ENOG4108VKG metal-dependent hydrolase GH768_RS04340 ENOG4105EE0 oxidoreductase GH768_RS04345 ENOG4105DU1 integral membrane protein, terc GH768_RS04355 ENOG4105CTX dehydratase GH768_RS04365 ENOG4105DPW Major facilitator superfamily MFS_1 GH768_RS04370 ENOG4107YCY Transcriptional regulator GH768_RS04375 ENOG4106W5V Membrane GH768_RS04385 ENOG4105WAY exported protein GH768_RS04390 ENOG4105NE1 Conserved Protein GH768_RS04395 ENOG41090KG Inner membrane protein YqjE GH768_RS04400 ENOG4105YJD GH768_RS04405 ENOG4108VBZ doxx family GH768_RS04410 ENOG4105CHF Glutathione S-transferase GH768_RS04415 ENOG4105KAF membrAne GH768_RS04420 ENOG4105CWB LysR family transcriptional Regulator GH768_RS04425 ENOG4108CNN domain protein GH768_RS04430 ENOG4106D80 Uncharacterized protein YhaL GH768_RS04440 ENOG4105C44 Serine transporter GH768_RS04445 ENOG4105EJQ L-serine dehydratase GH768_RS04450 ENOG4105C6N Formate acetyltransferase GH768_RS04460 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) GH768_RS04465 ENOG4105C7B Threonine dehydratase GH768_RS04470 ENOG410811B TRANSCRIPTIONal GH768_RS04485 ENOG4105E98 transcriptional regulator DeoR family GH768_RS04490 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GH768_RS04495 ENOG4105CE4 GlcNAc 6-P deacetylase GH768_RS04500 ENOG4105E70 isomerase GH768_RS04505 ENOG4105D2N Aldolase GH768_RS04510 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GH768_RS04530 ENOG4105W4M Transport-associated protein GH768_RS04535 ENOG4105K4T epimerase GH768_RS04540 ENOG4107R7Y intracellular protease Pfpi family GH768_RS04555 ENOG4108YYD acetyltransferase GH768_RS04580 ENOG4105CIC tryptophan-specific transport protein GH768_RS04585 ENOG4105C1J atp-dependent rna helicase GH768_RS04615 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GH768_RS04620 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GH768_RS04625 ENOG4105CHV Transcription elongation factor NusA GH768_RS04630 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GH768_RS04640 ENOG4105CDH Citrulline--aspartate ligase GH768_RS04650 ENOG4105NTZ Preprotein translocase subunit SecG GH768_RS04655 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GH768_RS04660 ENOG4105EEI dihydropteroate synthase GH768_RS04665 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GH768_RS04675 ENOG4105HBR Rna-binding protein GH768_RS04680 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GH768_RS04685 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GH768_RS04695 ENOG4105QYV Membrane GH768_RS04700 ENOG4105K46 50S ribosomal protein l27 GH768_RS04710 ENOG4105EAH synthase GH768_RS04715 ENOG4105HVQ Regulatory factor of maltose metabolism GH768_RS04725 ENOG4105VFK BolA family GH768_RS04730 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane GH768_RS04735 ENOG4105E3I toluene tolerance GH768_RS04740 ENOG4107PE3 Mammalian cell entry related domain protein GH768_RS04745 ENOG4105CY3 ABC transporter, permease GH768_RS04750 ENOG4105DHJ ABC, transporter GH768_RS04755 ENOG4105FEU K -dependent Na -Ca exchanger GH768_RS04760 ENOG4105C2X Arabinose 5-phosphate isomerase GH768_RS04765 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GH768_RS04770 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) GH768_RS04775 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GH768_RS04780 ENOG4108IUZ ABC transporter GH768_RS04785 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH768_RS04790 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GH768_RS04795 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GH768_RS04800 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GH768_RS04805 ENOG41080Z8 PHOSPHOCARRIER protein GH768_RS04810 ENOG4108NIH transferase activity, transferring phosphorus-containing groups GH768_RS04820 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GH768_RS04825 ENOG4105BZU Histidine kinase GH768_RS04830 ENOG4105N5T Radical SAM Protein GH768_RS04835 ENOG4105CBC glutamate synthase GH768_RS04840 ENOG4105BZ8 glutamate synthase GH768_RS04850 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GH768_RS04855 ENOG4105DZC cytosine deaminase GH768_RS04860 ENOG4108R66 Conserved Protein GH768_RS04875 ENOG4105JHE Major Facilitator Superfamily GH768_RS04890 ENOG4105KB2 stringent starvation protein b GH768_RS04895 ENOG4107MKT Stringent starvation protein a GH768_RS04910 ENOG4105D6Z AFG1 family ATPase GH768_RS04915 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GH768_RS04920 ENOG4105C0H protease GH768_RS04930 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GH768_RS04940 ENOG4105RID UPF0379 protein yhcN GH768_RS04950 ENOG4105UNR (Barnase) inhibitor GH768_RS04960 ENOG4105Y49 secretion protein, HlyD family GH768_RS04965 ENOG4105ZQC membrane protein AaeX GH768_RS04970 ENOG4105CR8 Transcriptional regulator GH768_RS04980 ENOG4105D1U peptidase U62 modulator of DNA gyrase GH768_RS04985 ENOG4105QD6 exported protein GH768_RS04990 ENOG4105C03 ribonuclease GH768_RS04995 ENOG4108Z03 MAF-like protein GH768_RS05000 ENOG4105VQ7 Rod shape-determining protein MreD GH768_RS05005 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GH768_RS05015 ENOG41062P1 Diguanylate cyclase phosphodiesterase GH768_RS05020 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GH768_RS05035 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GH768_RS05040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GH768_RS05045 ENOG4105RG0 Membrane GH768_RS05050 ENOG4108IA2 Sodium pantothenate symporter GH768_RS05055 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GH768_RS05060 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GH768_RS05070 ENOG4105CEC DNA methylase N-4 N-6 GH768_RS05075 ENOG41061ME transport protein GH768_RS05080 ENOG4105BZU Histidine kinase GH768_RS05085 ENOG4108XG4 DNA-binding transcriptional regulator GH768_RS05090 ENOG4105C1P efflux transporter, rnd family, mfp subunit GH768_RS05095 ENOG4105BZS acriflavin resistance protein GH768_RS05100 ENOG4105XCM membrane LIPOPROTEIN GH768_RS05145 ENOG4108Z0R Transferase GH768_RS05150 ENOG4105SG3 Protein of unknown function (DUF1488) GH768_RS05165 ENOG4108WI1 Dna topoisomerase GH768_RS05175 ENOG4105C79 DNA protecting protein DprA GH768_RS05195 ENOG4105C1A potassium transporter peripheral membrane GH768_RS05200 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GH768_RS05205 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system GH768_RS05210 ENOG4105W1Y Transcriptional regulator GH768_RS05215 ENOG4105VTS DnaJ-like, subfamily C GH768_RS05220 ENOG4108ZT0 50S ribosomal protein l17 GH768_RS05230 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GH768_RS05245 ENOG41067V7 50S ribosomal protein L36 GH768_RS05250 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GH768_RS05260 ENOG4105VPB 50S ribosomal protein L30 GH768_RS05285 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GH768_RS05290 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GH768_RS05295 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GH768_RS05305 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GH768_RS05310 ENOG41083MP 50s ribosomal protein l29 GH768_RS05330 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GH768_RS05360 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GH768_RS05365 ENOG4108UQY Iron-storage protein GH768_RS05370 ENOG4105W53 bacterioferritin-associated ferredoxin GH768_RS05375 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GH768_RS05380 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GH768_RS05385 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GH768_RS05410 ENOG4105WWK YheO domain protein GH768_RS05415 ENOG4108V1T peptidylprolyl cis-trans isomerase GH768_RS05420 ENOG4105VRX Protein slyX homolog GH768_RS05425 ENOG4108YZY peptidylprolyl cis-trans isomerase GH768_RS05430 ENOG4105VKU nucleicacid-binding protein GH768_RS05445 ENOG4105C5H ABC transporter GH768_RS05450 ENOG4105N0V mono-oxygenase ydhR GH768_RS05455 ENOG4105DNZ Alpha Beta Hydrolase GH768_RS05465 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GH768_RS05470 ENOG4108UKZ OsmC family GH768_RS05475 ENOG4107RYR Transcriptional regulator, Crp Fnr family GH768_RS05480 ENOG410613R integral membrane protein, YccS YhfK family GH768_RS05485 ENOG4105C8Y Acetylornithine aminotransferase GH768_RS05490 ENOG4105DDQ anthranilate synthase GH768_RS05495 ENOG4105MZU cell filamentation protein GH768_RS05500 ENOG4106195 uncharacterized protein yhfG GH768_RS05505 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GH768_RS05515 ENOG4107QZF nitrite reductase NADPH large subunit GH768_RS05520 ENOG4105WZK nitrite reductase NADPH small subunit GH768_RS05525 ENOG4107V9H nitrite transporter GH768_RS05535 ENOG4107EF2 surface-exposed virulence protein GH768_RS05540 ENOG4105VYH GH768_RS05545 ENOG4105C31 Tryptophanyl-tRNA synthetase GH768_RS05555 ENOG4105DJV ribulose-phosphate 3-epimerase GH768_RS05560 ENOG4105DFE Dna adenine methylase GH768_RS05565 ENOG4105EGB membrane protein DamX GH768_RS05580 ENOG4105E4G Type IV pilus GH768_RS05585 ENOG4105ITY Required for the use of extracellular DNA as a nutrient GH768_RS05590 ENOG4105XPX DNA utilization protein HofO GH768_RS05595 ENOG41065NF Fimbrial assembly family protein GH768_RS05600 ENOG4108U1Q Pilus assembly protein GH768_RS05605 ENOG4108JQC penicillin-binding protein 1A GH768_RS05610 ENOG4107RK2 ADP-ribose diphosphatase NudE GH768_RS05620 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 GH768_RS05625 ENOG4105VEJ Heat shock protein GH768_RS05630 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GH768_RS05635 ENOG4108MAJ Membrane GH768_RS05640 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GH768_RS05645 ENOG4105E0F Histidine kinase GH768_RS05655 ENOG4108RRZ Transcription elongation factor GreB GH768_RS05660 ENOG4105BZM domain protein GH768_RS05665 ENOG4105XFK Ferrous iron transport protein A GH768_RS05680 ENOG4105DNE Transposase GH768_RS05690 ENOG4105MJ2 Competence protein GH768_RS05700 ENOG4105C6Z Gluconate GH768_RS05705 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GH768_RS05710 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GH768_RS05715 ENOG41061ZR Transcriptional regulator GH768_RS05720 ENOG4105E98 transcriptional regulator DeoR family GH768_RS05725 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GH768_RS05730 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GH768_RS05735 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GH768_RS05740 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GH768_RS05760 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GH768_RS05765 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GH768_RS05770 ENOG4105C6Z Gluconate GH768_RS05775 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GH768_RS05780 ENOG4105DIQ Transcriptional regulator GH768_RS05785 ENOG4105C2I pirin domain protein GH768_RS05790 ENOG4105D9R oxidoreductase GH768_RS05795 ENOG4105GMB type VI secretion system effector, hcp1 family GH768_RS05800 ENOG4106FA4 GH768_RS05805 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GH768_RS05810 ENOG4105WC8 Conserved Protein GH768_RS05815 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GH768_RS05820 ENOG4108IJ9 (ABC) transporter GH768_RS05830 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GH768_RS05835 ENOG4105BZ7 extracellular solute-binding protein family 1 GH768_RS05840 ENOG4108IV0 ABC, transporter GH768_RS05845 ENOG4105C0Z ABC transporter GH768_RS05850 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GH768_RS05855 ENOG4105C32 Amino acid ABC transporter (Permease) GH768_RS05860 ENOG4105CP9 extracellular ligand-binding receptor GH768_RS05865 ENOG4105U59 -acetyltransferase GH768_RS05870 ENOG4105CP9 extracellular ligand-binding receptor GH768_RS05880 ENOG4105CRP Part of the ABC transporter FtsEX involved in GH768_RS05885 ENOG4105CAK Cell division ATP-binding protein ftsE GH768_RS05890 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GH768_RS05895 ENOG4106H78 methyltransferase GH768_RS05900 ENOG4105MG3 Membrane GH768_RS05910 ENOG4107FS9 Membrane GH768_RS05920 ENOG4105C8Q Methyl-accepting chemotaxis GH768_RS05930 ENOG4105EX9 Membrane GH768_RS05935 ENOG4108W1V Lipoprotein GH768_RS05945 ENOG4105DSF transport protein GH768_RS05950 ENOG4107YAK holo-(acyl carrier protein) synthase 2 GH768_RS05960 ENOG4105CMI transporter GH768_RS05965 ENOG4105CJ1 ABC, transporter GH768_RS05970 ENOG4105D0S secretion protein (HlyD GH768_RS05975 ENOG4105CBX hi0933 family GH768_RS05980 ENOG4105CJ3 phosphate transporter GH768_RS05990 ENOG4108M6U Universal stress protein A GH768_RS05995 ENOG4105DUX Transporter GH768_RS06005 ENOG4105DGW oligopeptidase A GH768_RS06015 ENOG4105D6S protein involved in catabolism of external DNA GH768_RS06020 ENOG4105DC8 reductase GH768_RS06040 ENOG4106S2D Transcriptional regulator GH768_RS06045 ENOG4105CBN LysR family transcriptional regulator GH768_RS06050 ENOG4107H3J ribonuclease GH768_RS06055 ENOG4105CSH Transporter GH768_RS06060 ENOG41066T0 asmA family GH768_RS06065 ENOG4105CMB EAL domain-containing protein GH768_RS06070 ENOG4107SS6 2-dehydro-3-deoxygluconokinase GH768_RS06075 ENOG4105CS0 peptidase GH768_RS06085 ENOG4105BZU Histidine kinase GH768_RS06090 ENOG4105EJG cellulose synthase GH768_RS06095 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GH768_RS06100 ENOG4107EEX Cellulose synthase regulator protein GH768_RS06105 ENOG4107QZ7 Cellulose synthase catalytic subunit GH768_RS06110 ENOG4105UTS cellulose synthase operon protein YhjQ GH768_RS06115 ENOG410661M cytoplasmic protein GH768_RS06125 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT GH768_RS06130 ENOG4105D1V cellulose synthase operon protein YhjU GH768_RS06145 ENOG4105C44 Serine transporter GH768_RS06150 ENOG4108JQ7 (ABC) transporter GH768_RS06155 ENOG4105C3U ABC transporter GH768_RS06160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH768_RS06165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH768_RS06170 ENOG4105DEF Extracellular solute-binding protein, family 5 GH768_RS06190 ENOG4105DIJ Phosphoethanolamine transferase GH768_RS06195 ENOG4105EAX Putative lipase GH768_RS06200 ENOG4108R3E Dna-3-methyladenine glycosylase i GH768_RS06205 ENOG4105HNP -acetyltransferase GH768_RS06210 ENOG4107QY8 reductase GH768_RS06215 ENOG4108ZG0 Ompa motb domain protein GH768_RS06225 ENOG4106JH6 (LipO)protein GH768_RS06230 ENOG4105MVF Transcriptional regulator GH768_RS06260 ENOG4105MEV Acyl-transferase GH768_RS06270 ENOG4105CMG Carbohydrate kinase GH768_RS06280 ENOG4105T16 Transcriptional regulator (AraC family) GH768_RS06285 ENOG4108UR8 BAX protein GH768_RS06295 ENOG4105JKW Valine--pyruvate aminotransferase GH768_RS06300 ENOG4108XIB electron transport protein ysaA GH768_RS06305 ENOG4105J4Q Transcriptional regulator GH768_RS06315 ENOG4108R66 Conserved Protein GH768_RS06320 ENOG4108M5W GH768_RS06325 ENOG4105DJB Major Facilitator Superfamily GH768_RS06330 ENOG4105CMG Carbohydrate kinase GH768_RS06335 ENOG4105H6Q decarboxylase GH768_RS06340 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase GH768_RS06345 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GH768_RS06355 ENOG4105CT4 transporter GH768_RS06365 ENOG4105C26 Dehydrogenase GH768_RS06370 ENOG41066F8 ROK family GH768_RS06375 ENOG4105C0A alcohol dehydrogenase GH768_RS06380 ENOG4105EM7 Selenocysteine-specific translation elongation factor GH768_RS06390 ENOG4108U78 Glutathione S-transferase GH768_RS06395 ENOG4105CTS PTS system mannitol-specific GH768_RS06405 ENOG4105E61 Mannitol repressor protein GH768_RS06415 ENOG4108YYI Protein of unknown function (DUF2810) GH768_RS06420 ENOG4105DAA L-lactate GH768_RS06425 ENOG41073TP transcriptional regulator GH768_RS06435 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GH768_RS06440 ENOG4105D7W serine acetyltransferase GH768_RS06445 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GH768_RS06450 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GH768_RS06455 ENOG4105VW4 glutaredoxin 3 GH768_RS06460 ENOG4107YZP Rhodanese domain protein GH768_RS06470 ENOG41063SB peptidase GH768_RS06475 ENOG4105PXI polysaccharide deacetylase GH768_RS06480 ENOG4105K64 Glycosyl transferase, family 2 GH768_RS06485 ENOG4105CPQ Dehydrogenase GH768_RS06490 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GH768_RS06500 ENOG4105XA0 heptosyltransferase ii GH768_RS06505 ENOG4105D16 lipopolysaccharide heptosyltransferase i GH768_RS06510 ENOG4108FRV O-antigen ligase GH768_RS06520 ENOG4108QD8 lipopolysaccharide core biosynthesis protein GH768_RS06525 ENOG4108PDR lipopolysaccharide core biosynthesis protein GH768_RS06530 ENOG4105X1N Glycosyl transferase family 8 GH768_RS06535 ENOG4106AH0 Glycosyl Transferase GH768_RS06540 ENOG4107XU6 Glycosyl transferase (Group 1 GH768_RS06550 ENOG4107543 (lipo)polysaccharide GH768_RS06555 ENOG4107RJ7 Glycosyl transferase (Group 1 GH768_RS06560 ENOG4105DKP glycosyl transferase, family 9 GH768_RS06565 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GH768_RS06595 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GH768_RS06615 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GH768_RS06620 ENOG4105DSJ YicC domain protein GH768_RS06635 ENOG4105EN6 Membrane GH768_RS06655 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GH768_RS06660 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GH768_RS06665 ENOG4105CB5 ATP-dependent DNA helicase recG GH768_RS06670 ENOG4105D6U Sodium Glutamate Symporter GH768_RS06675 ENOG4105C2W permease GH768_RS06680 ENOG4105JV1 AsmA family GH768_RS06685 ENOG4105CJQ hydrolase, family 31 GH768_RS06690 ENOG4105CT4 transporter GH768_RS06705 ENOG4105CHJ isochorismatase hydrolase GH768_RS06730 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GH768_RS06735 ENOG4105KT7 mgtC SapB transporter GH768_RS06740 ENOG4108UZ3 Transporter GH768_RS06780 ENOG4105F3R pts system mannose fructose sorbose family iid GH768_RS06785 ENOG4105ETZ PTS System GH768_RS06790 ENOG4105DAS pts system GH768_RS06810 ENOG4105CS2 ec 3.2.1.21 GH768_RS06820 ENOG4108SAJ Protein of unknown function (DUF1198) GH768_RS06825 ENOG4105CXY transporter GH768_RS06830 ENOG4105CXY transporter GH768_RS06835 ENOG4105BZU Histidine kinase GH768_RS06840 ENOG4108KX4 response regulator GH768_RS06850 ENOG4105EDR glucose galactose transporter GH768_RS06860 ENOG4107FB0 transcriptional regulator DeoR family GH768_RS06865 ENOG4105M71 acetolactate synthase 1 regulatory subunit GH768_RS06870 ENOG4105C7K acetolactate synthase GH768_RS06895 ENOG4105E5M Multidrug resistance protein D GH768_RS06905 ENOG4105J13 transcriptional regulator GH768_RS06910 ENOG4105JP4 Inner membrane protein yidG GH768_RS06915 ENOG4105VG5 Membrane GH768_RS06930 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) GH768_RS06940 ENOG4105R2A (LipO)protein GH768_RS06945 ENOG4105D99 atp gtp-binding protein GH768_RS06950 ENOG4105KWW Biogenesis protein GH768_RS06955 ENOG4107QX9 Thiol disulfide interChange protein GH768_RS06960 ENOG4105DA4 cytochrome c-type biogenesis protein GH768_RS06970 ENOG4105X3C heme exporter protein GH768_RS06975 ENOG41060IM Heme exporter protein GH768_RS06980 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GH768_RS06985 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GH768_RS06990 ENOG4105CA0 peroxidase GH768_RS07000 ENOG4108EM1 reductase GH768_RS07005 ENOG4105CUW cytochrome C-TYPE protein GH768_RS07010 ENOG4106WF9 DNA-binding transcriptional regulator TorR GH768_RS07015 ENOG4108SV3 Tmao reductase system periplasmic protein tort GH768_RS07020 ENOG4105BZU Histidine kinase GH768_RS07040 ENOG410667J hydrolase GH768_RS07045 ENOG4105DPW Major facilitator superfamily MFS_1 GH768_RS07050 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria GH768_RS07070 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH768_RS07080 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GH768_RS07090 ENOG4105VG0 50S ribosomal protein l34 GH768_RS07125 ENOG4105E8Q phosphopantetheinyl transferase GH768_RS07130 ENOG4108YYH Nadph-dependent fmn reductase GH768_RS07135 ENOG4105C7N Xanthine uracil vitamin C permease GH768_RS07140 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 GH768_RS07150 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GH768_RS07155 ENOG4105E2Z phosphate ABC transporter (Permease GH768_RS07160 ENOG4105C8U phosphate abc transporter GH768_RS07165 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GH768_RS07170 ENOG4105CS2 ec 3.2.1.21 GH768_RS07175 ENOG41066F8 ROK family GH768_RS07185 ENOG4105VCP PTS System GH768_RS07190 ENOG4105CK1 PTS System GH768_RS07210 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GH768_RS07215 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GH768_RS07220 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GH768_RS07240 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GH768_RS07255 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation GH768_RS07270 ENOG4105QTB Flavodoxin GH768_RS07275 ENOG4108VVK transcriptional Regulator, AsnC GH768_RS07295 ENOG4105DFH Transport of potassium into the cell (By similarity) GH768_RS07310 ENOG4105CNN ABC, transporter GH768_RS07315 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GH768_RS07320 ENOG4108RVA ribokinase GH768_RS07325 ENOG4105ETE Transcriptional regulator (LacI family GH768_RS07330 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH768_RS07335 ENOG4107EJG GntR family transcriptional regulator GH768_RS07380 ENOG4105C0P Mg chelatase subunit ChlI GH768_RS07395 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GH768_RS07400 ENOG4105CM2 brancheD-chain amino acid aminotransferase GH768_RS07410 ENOG4105C7B Threonine dehydratase GH768_RS07420 ENOG4105RKW reductase (By GH768_RS07425 ENOG4105CMT Dihydroxyacetone kinase GH768_RS07430 ENOG4105EMY transcriptional regulator GH768_RS07440 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GH768_RS07450 ENOG4107SXA Phosphorylase GH768_RS07455 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GH768_RS07460 ENOG4105C4R Atp-dependent dna helicase GH768_RS07470 ENOG4105C1J atp-dependent rna helicase GH768_RS07485 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GH768_RS07490 ENOG4105ESV Glycosyl transferase, family 4 GH768_RS07495 ENOG4105SFE lipopolysaccharide biosynthesis protein GH768_RS07500 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GH768_RS07505 ENOG4108IJ1 Dehydrogenase GH768_RS07510 ENOG4105C1B dTDP-glucose 4-6-dehydratase GH768_RS07515 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GH768_RS07520 ENOG4108WJ1 acetyltransferase GH768_RS07525 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GH768_RS07530 ENOG4105EGZ biosynthesis protein GH768_RS07545 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family GH768_RS07550 ENOG4105C85 amino acid GH768_RS07575 ENOG410601J HemY protein GH768_RS07580 ENOG4105ECF c-methyltransferase GH768_RS07585 ENOG41076E6 Uroporphyrinogen-III Synthase GH768_RS07595 ENOG4107T0K Adenylate cyclase GH768_RS07600 ENOG4105XQ6 frataxin-like protein GH768_RS07605 ENOG4105S7Z (LipO)protein GH768_RS07615 ENOG4105CT0 Protein of unknown function, DUF484 GH768_RS07620 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH768_RS07625 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GH768_RS07630 ENOG4105C4R Atp-dependent dna helicase GH768_RS07635 ENOG4107QUT magnesium and cobalt transport protein CorA GH768_RS07650 ENOG4105FR1 rard protein GH768_RS07655 ENOG4108VUY thioesterase Superfamily protein GH768_RS07660 ENOG4105HDD phospholipase GH768_RS07665 ENOG4105C9U ATP-dependent DNA helicase RecQ GH768_RS07670 ENOG4105CCF Lysine exporter protein (Lyse ygga) GH768_RS07675 ENOG410829K Lysine exporter protein (Lyse ygga) GH768_RS07680 ENOG4108EUD Lysophospholipase GH768_RS07685 ENOG4105DQF Hydrolase GH768_RS07690 ENOG4105EMK carboxylate amino acid amine transporter GH768_RS07695 ENOG4105DZ2 Transcriptional regulator GH768_RS07705 ENOG4105C4X radical SAM domain protein GH768_RS07710 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GH768_RS07715 ENOG4107SXA Phosphorylase GH768_RS07720 ENOG4105CGY Dna recombination protein GH768_RS07730 ENOG4105JC1 sterol-binding domain protein GH768_RS07740 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GH768_RS07745 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GH768_RS07750 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GH768_RS07755 ENOG4105F8V Hydrolase, tatD family GH768_RS07760 ENOG4105MDZ Transcriptional activator rfaH GH768_RS07765 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GH768_RS07770 ENOG4107QK7 reductase GH768_RS07775 ENOG4105CHU acetyl-coa acetyltransferase GH768_RS07780 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) GH768_RS07790 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GH768_RS07795 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GH768_RS07800 ENOG4108RR8 protoporphyrinogen oxidase GH768_RS07825 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GH768_RS07830 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GH768_RS07835 ENOG4105PC1 Conserved Protein GH768_RS07845 ENOG4108Z33 Thiol disulfide Interchange Protein GH768_RS07850 ENOG4106HNH Acyl-transferase GH768_RS07855 ENOG4105C2M dna polymerase I GH768_RS07875 ENOG4105D4P Coproporphyrinogen iii oxidase GH768_RS07880 ENOG4106FIY GH768_RS07885 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH768_RS07890 ENOG4105CUX Signal transduction histidine kinase GH768_RS07895 ENOG4105C5F glutamine synthetase GH768_RS07900 ENOG4105CI3 gtp-binding protein typa GH768_RS07905 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is GH768_RS07910 ENOG4105CT4 transporter GH768_RS07915 ENOG4105CT4 transporter GH768_RS07920 ENOG4105CJQ hydrolase, family 31 GH768_RS07925 ENOG4107WI4 Aldose-1-epimerase GH768_RS07930 ENOG4107QKS N-acylglucosamine 2-epimerase GH768_RS07935 ENOG4105D2M Aldolase GH768_RS07940 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GH768_RS07945 ENOG4108MGF sugar kinase GH768_RS07950 ENOG4105E98 transcriptional regulator DeoR family GH768_RS07955 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 GH768_RS07970 ENOG4105SUU thioesterase domain GH768_RS07980 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system GH768_RS07995 ENOG4108MG3 formate dehydrogenase GH768_RS08000 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GH768_RS08035 ENOG4108JJA ABC, transporter GH768_RS08040 ENOG4108MBX Secretion Protein GH768_RS08070 ENOG4105CTQ phosphohexokinase GH768_RS08085 ENOG4105D2N Aldolase GH768_RS08110 ENOG4108UMN azlc family GH768_RS08120 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GH768_RS08125 ENOG4105C0A alcohol dehydrogenase GH768_RS08135 ENOG4105DKG l-rhamnose isomerase GH768_RS08145 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GH768_RS08160 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GH768_RS08170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH768_RS08175 ENOG4108RPX mosc domain containing protein GH768_RS08180 ENOG4105E0F Histidine kinase GH768_RS08185 ENOG4105E3W Two component transcriptional regulator (Winged helix family GH768_RS08190 ENOG4105FMW periplasmic GH768_RS08235 ENOG4105CTQ phosphohexokinase GH768_RS08240 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GH768_RS08245 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) GH768_RS08255 ENOG4107QPK )-transporter GH768_RS08265 ENOG4105EBK exported protein GH768_RS08270 ENOG4108VTS Membrane GH768_RS08275 ENOG4105DP0 ferredoxin-NADP reductase GH768_RS08280 ENOG4105CBT Fructose-1,6-bisphosphatase GH768_RS08290 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GH768_RS08300 ENOG4108JUB Transcriptional regulator GH768_RS08305 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GH768_RS08310 ENOG4105CTX dehydratase GH768_RS08325 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GH768_RS08340 ENOG41063M6 Cell Division Protein GH768_RS08345 ENOG4105ETE Transcriptional regulator (LacI family GH768_RS08350 ENOG4105C25 Primosomal protein n' GH768_RS08360 ENOG4108QGT oligogalacturonate-specific porin GH768_RS08365 ENOG4105CT4 transporter GH768_RS08375 ENOG4105C28 cystathionine GH768_RS08380 ENOG4105CFH Aspartokinase GH768_RS08390 ENOG4105CGH 5'-nucleotidase GH768_RS08395 ENOG4105SYT Methylenetetrahydrofolate reductase GH768_RS08405 ENOG4105DCT glycerol dehydrogenase GH768_RS08415 ENOG4106R3P AraC family transcriptional regulator GH768_RS08420 ENOG4105DIJ Phosphoethanolamine transferase GH768_RS08450 ENOG4105C5Q Transcriptional regulator GH768_RS08460 ENOG4105EJ2 Transcriptional regulator GH768_RS08465 ENOG4108Y73 Membrane GH768_RS08510 ENOG4105D4A Cell wall formation (By similarity) GH768_RS08515 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GH768_RS08550 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GH768_RS08555 ENOG4105PM1 preprotein translocase subunit SecE GH768_RS08560 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GH768_RS08575 ENOG4108VZM 50s ribosomal protein L10 GH768_RS08585 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GH768_RS08590 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GH768_RS08620 ENOG4105D41 biosynthesis protein thiH GH768_RS08630 ENOG4105WHD thiamine biosynthesis protein ThiS GH768_RS08635 ENOG4105D06 uba thif-type nad fad binding protein GH768_RS08640 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GH768_RS08645 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GH768_RS08650 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) GH768_RS08665 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GH768_RS08670 ENOG4105R2J Conserved Protein GH768_RS08680 ENOG4108T8B Protein of unknown function (DUF1481) GH768_RS08690 ENOG4105BZU Histidine kinase GH768_RS08695 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH768_RS08700 ENOG4105C12 Phosphoribosylglycinamide synthetase GH768_RS08730 ENOG4105K5X acetyltransferase GH768_RS08740 ENOG4107QP3 malate synthase g GH768_RS08745 ENOG4108I9X Isocitrate lyase GH768_RS08760 ENOG41069M3 Transcriptional regulator GH768_RS08770 ENOG4105C3R Methionine synthase GH768_RS08775 ENOG4105EAM Na Pi-cotransporter GH768_RS08790 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GH768_RS08795 ENOG4105FE9 pseudouridine synthase GH768_RS08800 ENOG4108ZR5 Conserved Protein GH768_RS08805 ENOG4105CFH Aspartokinase GH768_RS08820 ENOG4108MDC (LipO)protein GH768_RS08825 ENOG4108Q9C Periplasmic Protein GH768_RS08830 ENOG4105E3R (LipO)protein GH768_RS08835 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GH768_RS08840 ENOG4107QNK )-transporter GH768_RS08845 ENOG4105EG2 ABC transporter, permease GH768_RS08850 ENOG4105D56 permease protein GH768_RS08855 ENOG4107FKK extracellular solute-binding protein family 1 GH768_RS08860 ENOG4108IJ9 (ABC) transporter GH768_RS08870 ENOG4107W52 maltose operon periplasmic protein GH768_RS08890 ENOG41080IJ Diacylglycerol kinase GH768_RS08895 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GH768_RS08900 ENOG4107R73 Mate efflux family protein GH768_RS08910 ENOG4105VDW Csbd family GH768_RS08915 ENOG4105MYN Zinc uptake regulation protein GH768_RS08925 ENOG4105E2A Dehydrogenase GH768_RS08930 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GH768_RS08935 ENOG4105P4Z Phage shock protein G GH768_RS08940 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GH768_RS08945 ENOG4105CDU Replicative dna helicase GH768_RS08950 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GH768_RS08955 ENOG4105CGF Aromatic amino acid aminotransferase GH768_RS08960 ENOG4105F0S class B acid phosphatase GH768_RS08970 ENOG4105MSB protein, conserved in bacteria GH768_RS08985 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GH768_RS08990 ENOG4108UUM single-stranded DNA-binding protein GH768_RS09025 ENOG4105PMV Membrane GH768_RS09030 ENOG4108M8H domain protein GH768_RS09035 ENOG4108W3Q Transcriptional regulator GH768_RS09040 ENOG4108Z4X TRANSCRIPTIONal GH768_RS09050 ENOG4105C7N Xanthine uracil vitamin C permease GH768_RS09055 ENOG4105EEQ Na H antiporter GH768_RS09060 ENOG4105CMU LysR family (Transcriptional regulator GH768_RS09070 ENOG41067MG lrgb family GH768_RS09075 ENOG4107QN1 sodium solute GH768_RS09080 ENOG41062QD Membrane GH768_RS09085 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GH768_RS09095 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit GH768_RS09100 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GH768_RS09105 ENOG4105DVI reductase, NrfD GH768_RS09110 ENOG4108QKW cytochrome c-type biogenesis protein GH768_RS09120 ENOG4108W0S formate-dependent nitrite reductase complex GH768_RS09125 ENOG4105CK2 sodium dicarboxylate symporter GH768_RS09130 ENOG41082ND Uncharacterized protein yjcO GH768_RS09140 ENOG4105ETP RND efflux system, outer membrane lipoprotein GH768_RS09145 ENOG4108MI0 Resistance protein GH768_RS09150 ENOG4105J12 Multidrug resistance protein mdtN GH768_RS09155 ENOG4106833 GH768_RS09160 ENOG4105EUZ Beta-lactamase domain protein GH768_RS09170 ENOG410870W N-acetyltransferase GH768_RS09175 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase GH768_RS09180 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GH768_RS09185 ENOG4105CSH Transporter GH768_RS09195 ENOG4105ECM Sensor protein basS pmrB GH768_RS09200 ENOG4105XJC Two component transcriptional regulator (Winged helix family GH768_RS09205 ENOG4105DIJ Phosphoethanolamine transferase GH768_RS09210 ENOG4105D5Q Arginine ornithine antiporter GH768_RS09215 ENOG4106ZGR Transcriptional regulator GH768_RS09220 ENOG4105CXN decarboxylase GH768_RS09225 ENOG4108K2B transcriptional regulator GH768_RS09230 ENOG4105F8D glycoside hydrolase family 4 GH768_RS09235 ENOG4105CT4 transporter GH768_RS09240 ENOG4107GFK fumarate GH768_RS09245 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GH768_RS09255 ENOG4108MRH transcriptional regulatory protein GH768_RS09260 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GH768_RS09265 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GH768_RS09270 ENOG4105EHG Permease protein GH768_RS09275 ENOG4107R4I Periplasmic binding protein GH768_RS09280 ENOG4106QJH hemin transport protein GH768_RS09285 ENOG4107ENK receptor GH768_RS09300 ENOG4108ZK4 sdia-regulated domain-containing protein GH768_RS09305 ENOG4108N8T regulatoR GH768_RS09330 ENOG4108SIC Transcriptional regulator GH768_RS09345 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GH768_RS09350 ENOG4108IJ0 Aspartate ammonia-lyase GH768_RS09355 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GH768_RS09360 ENOG4105DVH amino acid GH768_RS09375 ENOG4108ZVF (LipO)protein GH768_RS09380 ENOG4105MTB Uncharacterized protein YjeJ GH768_RS09385 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GH768_RS09390 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GH768_RS09400 ENOG4106BSU Entericidin B GH768_RS09410 ENOG4105KPY Small multidrug resistance protein GH768_RS09420 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GH768_RS09430 ENOG4105E33 succinate dehydrogenase GH768_RS09435 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GH768_RS09445 ENOG4107SC7 Inner membrane transporter yjeM GH768_RS09455 ENOG4106CG8 Inner membrane protein YjeO GH768_RS09460 ENOG4105EGS Mechanosensitive ion channel GH768_RS09475 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GH768_RS09480 ENOG4106TNF Periplasmic binding protein GH768_RS09500 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GH768_RS09505 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GH768_RS09510 ENOG4105K8N protein family UPF0079, ATPase GH768_RS09515 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GH768_RS09530 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GH768_RS09535 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GH768_RS09540 ENOG4107QJR hflk protein GH768_RS09545 ENOG4105EPW hflc protein GH768_RS09565 ENOG4105BZ1 (ABC) transporter GH768_RS09570 ENOG4105DJY efflux transporter, rnd family, mfp subunit GH768_RS09575 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GH768_RS09600 ENOG4105CHR reductase GH768_RS09610 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GH768_RS09620 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GH768_RS09625 ENOG4105C2N RNA methyltransferase TrmH family group 3 GH768_RS09650 ENOG4105CSU acyl-Coa dehydrogenase GH768_RS09655 ENOG4105S17 UPF0379 protein yjfN GH768_RS09660 ENOG4105WSB biofilm stress and motility protein A GH768_RS09665 ENOG4108MXZ Esterase GH768_RS09670 ENOG4105DW5 Transcriptional regulator GH768_RS09680 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GH768_RS09690 ENOG4106ETB IIa component GH768_RS09710 ENOG4105KIT UPF0379 protein yjfY GH768_RS09720 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GH768_RS09725 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GH768_RS09730 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GH768_RS09735 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GH768_RS09745 ENOG4105FHY Opacity-associated protein A GH768_RS09750 ENOG4108V1T peptidylprolyl cis-trans isomerase GH768_RS09765 ENOG4105DXC membrane GH768_RS09770 ENOG4105ECR NmrA family GH768_RS09775 ENOG4105KVH Transcriptional regulator GH768_RS09780 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GH768_RS09785 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GH768_RS09790 ENOG4108UUE Transcriptional regulator GH768_RS09795 ENOG41061GZ Protein of unknown function (DUF1107) GH768_RS09800 ENOG4105C37 (CBS) domain GH768_RS09820 ENOG4108ZHD aig2 family GH768_RS09825 ENOG4105F0N pyrophosphate phospho-hydrolase GH768_RS09830 ENOG4105C8Q Methyl-accepting chemotaxis GH768_RS09840 ENOG4105DFU Cell wall formation (By similarity) GH768_RS09880 ENOG4105BZ1 (ABC) transporter GH768_RS09885 ENOG4105N42 UPF0307 protein GH768_RS09890 ENOG4105CMS peptidase U62, modulator of DNA gyrase GH768_RS09895 ENOG4108XVM Cytochrome b(562) GH768_RS09925 ENOG41069H0 dihydroorotase EC 3.5.2.3 GH768_RS09940 ENOG4105EMD TRANSCRIPTIONal GH768_RS09945 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A GH768_RS09955 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GH768_RS09960 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GH768_RS09965 ENOG4105CG3 alpha amylase, catalytic region GH768_RS09970 ENOG4105C5Y PTS System GH768_RS09975 ENOG4105D4X repressor GH768_RS09990 ENOG4105KME endoribonuclease L-psp GH768_RS10005 ENOG41077AM PyrBI operon attenuator GH768_RS10015 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GH768_RS10020 ENOG4105CSX c4-dicarboxylate anaerobic carrier GH768_RS10025 ENOG4105DBV ornithine carbamoyltransferase GH768_RS10030 ENOG4105C5B carbamate kinase GH768_RS10035 ENOG4105CEU Arginine dihydrolase GH768_RS10040 ENOG4105XEP YhcH YjgK YiaL family protein GH768_RS10045 ENOG4105DBV ornithine carbamoyltransferase GH768_RS10050 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) GH768_RS10055 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GH768_RS10060 ENOG4108MJ3 acetyltransferase GH768_RS10090 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GH768_RS10095 ENOG4105MYG DNA polymerase iii, chi subunit GH768_RS10105 ENOG4108M8S permease YjgP YjgQ family protein GH768_RS10110 ENOG4108K5H permease YjgP YjgQ family protein GH768_RS10130 ENOG4105DQ4 alcohol dehydrogenase GH768_RS10160 ENOG4105EQR Transposase IS116 IS110 IS902 GH768_RS10190 ENOG4105CDU Replicative dna helicase GH768_RS10205 ENOG4105TNG K13735 adhesin invasin GH768_RS10220 ENOG4105DTA methyltransferase GH768_RS10230 ENOG4105KZM cytoplasmic protein GH768_RS10240 ENOG4106AM8 polysaccharide lyase family 8 GH768_RS10265 ENOG4105F3R pts system mannose fructose sorbose family iid GH768_RS10270 ENOG4105ETZ PTS System GH768_RS10275 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB GH768_RS10295 ENOG4105C6F GntR Family Transcriptional Regulator GH768_RS10315 ENOG4107YNJ LysR family Transcriptional regulator GH768_RS10320 ENOG4105DYB Isoaspartyl dipeptidase GH768_RS10325 ENOG4108P2H Inner membrane protein YjiG GH768_RS10330 ENOG41074DU domain protein GH768_RS10335 ENOG4105CBP Major Facilitator GH768_RS10340 ENOG4106BRA Membrane GH768_RS10345 ENOG41083G8 Multidrug resistance protein MdtM GH768_RS10355 ENOG4105C26 Dehydrogenase GH768_RS10385 ENOG4108F3G Type I restriction-modification system, R subunit GH768_RS10390 ENOG4106H3A restriction GH768_RS10410 ENOG4105CKI cobalamin synthesis protein GH768_RS10415 ENOG4105VCD cytoplasmic protein GH768_RS10425 ENOG4105D22 carbon starvation protein GH768_RS10430 ENOG4105C8Q Methyl-accepting chemotaxis GH768_RS10450 ENOG4108IQ3 PTS system GH768_RS10455 ENOG4105ETZ PTS System GH768_RS10460 ENOG4105F3R pts system mannose fructose sorbose family iid GH768_RS10465 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GH768_RS10470 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GH768_RS10480 ENOG4105RI1 glycoprotein receptor GH768_RS10485 ENOG4106CVF DNA replication protein GH768_RS10500 ENOG4105DWK Membrane GH768_RS10505 ENOG4108N8T regulatoR GH768_RS10510 ENOG4108T94 DNA-binding transcriptional activator BglJ GH768_RS10515 ENOG4108UIN ybak prolyl-trna synthetase associated region GH768_RS10520 ENOG4108819 ferric iron reductase GH768_RS10525 ENOG4105BZU Histidine kinase GH768_RS10530 ENOG4105YBH Protein of unknown function (DUF1435) GH768_RS10555 ENOG4108WPU DNA polymerase III subunit psi GH768_RS10560 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GH768_RS10565 ENOG4105PAD Hydrolase GH768_RS10575 ENOG4105K3G Periplasmic Protein GH768_RS10585 ENOG4108NRW Phospholipase, patatin family GH768_RS10590 ENOG4105EYA deoxyribonuclease GH768_RS10595 ENOG41076CZ activating enzyme GH768_RS10600 ENOG4105G0K glycine radical enzyme YjjI family GH768_RS10620 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GH768_RS10630 ENOG41062Z9 Membrane GH768_RS10635 ENOG4105EAC phosphoserine phosphatase GH768_RS10640 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GH768_RS10645 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase GH768_RS10650 ENOG4105C5H ABC transporter GH768_RS10655 ENOG4107SC1 transglycosylase GH768_RS10665 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GH768_RS10675 ENOG4105UEI Transcriptional Regulator AraC Family GH768_RS10680 ENOG4108RH0 Crea protein GH768_RS10705 ENOG4108VCD Chaperone GH768_RS10715 ENOG4108PNB DNA-binding transcriptional regulator GH768_RS10725 ENOG41065U4 response regulator GH768_RS10730 ENOG410759A GH768_RS10735 ENOG4106FVC RNA methyltransferase GH768_RS10745 ENOG4105CFH Aspartokinase GH768_RS10755 ENOG4105D98 threonine synthase GH768_RS10765 ENOG4105BZG amino acid carrier protein GH768_RS10770 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GH768_RS10775 ENOG4108RIR Molybdenum cofactor biosynthesis protein GH768_RS10780 ENOG4106HK8 GPR1 FUN34 yaaH family protein GH768_RS10785 ENOG4108QUJ UPF0174 protein YaaW GH768_RS10870 ENOG4105CGH 5'-nucleotidase GH768_RS10880 ENOG41061MV Arylsulfatase GH768_RS10885 ENOG4105C4X radical SAM domain protein GH768_RS10905 ENOG41063Z6 transcriptional regulator, lysR family GH768_RS10920 ENOG4105DTN riboflavin biosynthesis protein ribF GH768_RS10935 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GH768_RS10950 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GH768_RS10970 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GH768_RS10975 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GH768_RS10980 ENOG4108XNW Transcriptional activatory protein CaiF GH768_RS10995 ENOG4105E39 Enoyl-CoA hydratase GH768_RS11000 ENOG4105J5T Amp-dependent synthetase and ligase GH768_RS11010 ENOG4105C1G acyl-Coa dehydrogenase GH768_RS11015 ENOG4105C94 Transporter GH768_RS11030 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GH768_RS11035 ENOG4105WQV ferredoxin-like protein GH768_RS11040 ENOG4105C54 Major Facilitator superfamily GH768_RS11045 ENOG4105M5B (LipO)protein GH768_RS11050 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF GH768_RS11070 ENOG4105NWN ApaG protein GH768_RS11080 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GH768_RS11090 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GH768_RS11100 ENOG4105D3G Pseudouridine synthase GH768_RS11110 ENOG4105CQ2 DNA polymerase GH768_RS11125 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GH768_RS11140 ENOG41063TF transcriptional regulator (AraC GH768_RS11155 ENOG4108KF1 Membrane GH768_RS11185 ENOG4105S8Q sugar efflux transporter GH768_RS11190 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GH768_RS11205 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GH768_RS11215 ENOG41064T2 transcriptional regulator, lysR family GH768_RS11220 ENOG4105C7K acetolactate synthase GH768_RS11225 ENOG4108ZP8 Acetolactate synthase small subunit GH768_RS11230 ENOG4107B7Y DNA-binding transcriptional regulator FruR GH768_RS11245 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GH768_RS11250 ENOG4105CJN penicillin-binding protein GH768_RS11260 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GH768_RS11265 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GH768_RS11275 ENOG4105CNI cell division protein FtsW GH768_RS11295 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GH768_RS11300 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GH768_RS11305 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GH768_RS11330 ENOG4105M6F mutator MutT protein GH768_RS11335 ENOG4108FN7 Aldo keto reductase GH768_RS11340 ENOG410642W LysR family Transcriptional regulator GH768_RS11350 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GH768_RS11355 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GH768_RS11365 ENOG4105D7Q type ii secretion system GH768_RS11370 ENOG4107QHF type ii secretion system protein e GH768_RS11375 ENOG4108ZUW Major pilin subunit GH768_RS11380 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GH768_RS11390 ENOG4106A72 regulatory protein AmpE GH768_RS11395 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GH768_RS11400 ENOG4105CT4 transporter GH768_RS11425 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GH768_RS11430 ENOG4107QSN dihydrolipoamide acetyltransferase GH768_RS11435 ENOG4107QN2 dihydrolipoyl dehydrogenase GH768_RS11450 ENOG4108NST exported protein GH768_RS11455 ENOG4107QIJ Aconitate hydratase 2 GH768_RS11465 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GH768_RS11470 ENOG4107S2N Type III effector Hrp-dependent GH768_RS11475 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GH768_RS11480 ENOG4105MVE transcriptional regulator GH768_RS11495 ENOG4108ZRK uncharacterized protein yacC GH768_RS11500 ENOG4105E3B Multicopper oxidase GH768_RS11505 ENOG4105DZG Dehydrogenase GH768_RS11510 ENOG4108UGV hypoxanthine phosphoribosyltransferase GH768_RS11515 ENOG41077A9 carbonic anhydrase GH768_RS11520 ENOG4105DA5 (ABC) transporter GH768_RS11525 ENOG4105E3A (ABC) transporter GH768_RS11530 ENOG4108YTN IIa component GH768_RS11535 ENOG4107BJW polysaccharide deacetylase GH768_RS11540 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GH768_RS11550 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GH768_RS11555 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GH768_RS11560 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GH768_RS11565 ENOG4105DJ0 Poly(A) Polymerase GH768_RS11570 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GH768_RS11575 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GH768_RS11580 ENOG4105PW4 Sugar fermentation stimulation protein homolog GH768_RS11585 ENOG4107XID 2'-5' rna ligase GH768_RS11590 ENOG4105CQ7 ATP-dependent helicase GH768_RS11595 ENOG4105BZ4 penicillin-binding protein GH768_RS11600 ENOG4105E0K tonB-dependent siderophore receptor GH768_RS11605 ENOG4105E0A ABC, transporter GH768_RS11610 ENOG4105J76 Periplasmic binding protein GH768_RS11615 ENOG4105S6R Iron-hydroxamate transporter permease subunit GH768_RS11630 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GH768_RS11635 ENOG4105EN6 Membrane GH768_RS11640 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GH768_RS11655 ENOG4105C0H protease GH768_RS11670 ENOG4105CSH Transporter GH768_RS11675 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GH768_RS11685 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GH768_RS11690 ENOG4105CE9 30S ribosomal protein S2 GH768_RS11700 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GH768_RS11705 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GH768_RS11720 ENOG4105KNE Phosphatidate cytidylyltransferase GH768_RS11730 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GH768_RS11735 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GH768_RS11740 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GH768_RS11745 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GH768_RS11750 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GH768_RS11765 ENOG4105C0B DNA polymerase III (alpha subunit) GH768_RS11770 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GH768_RS11780 ENOG4105CXN decarboxylase GH768_RS11785 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GH768_RS11795 ENOG4105M1T rho-binding antiterminator GH768_RS11805 ENOG4108VWS Yaeq family GH768_RS11810 ENOG4108YZN class I peptide chain release factor GH768_RS11815 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GH768_RS11825 ENOG4108R96 Methyltransferase, YaeB family GH768_RS11830 ENOG4108R8X outer membrane lipoprotein GH768_RS11835 ENOG4105D01 (LipO)protein GH768_RS11840 ENOG4108UMI ABC transporter, permease GH768_RS11850 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GH768_RS11885 ENOG4105DFP Integrase GH768_RS11890 ENOG410600K aminopeptidase GH768_RS11905 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GH768_RS11910 ENOG4105GMB type VI secretion system effector, hcp1 family GH768_RS11935 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GH768_RS11985 ENOG4108WC9 type VI secretion system effector, hcp1 family GH768_RS11990 ENOG4105CS6 Rhs element vgr protein GH768_RS12060 ENOG4105E9H Lytic Murein transglycosylase GH768_RS12070 ENOG4105D1A Methyltransferase GH768_RS12075 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GH768_RS12080 ENOG4107RZZ dna polymerase iii epsilon subunit GH768_RS12090 ENOG4105T40 surface antigen msp4 family protein GH768_RS12105 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GH768_RS12110 ENOG4107QPN acyl-Coa dehydrogenase GH768_RS12120 ENOG4105E7A Glutamine amidotransferase GH768_RS12125 ENOG4105F7V ErfK ybiS ycfS ynhG family protein GH768_RS12135 ENOG4105CIN aminoacyl-histidine dipeptidase GH768_RS12140 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GH768_RS12155 ENOG4105FCK Membrane GH768_RS12165 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GH768_RS12215 ENOG4107QUY Guanine deaminase GH768_RS12240 ENOG4105JHE Major Facilitator Superfamily GH768_RS12245 ENOG4107QMH DNA methylase GH768_RS12250 ENOG4105D8D Type III GH768_RS12260 ENOG4105C4M (Ubiquinol oxidase) subunit I GH768_RS12265 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GH768_RS12280 ENOG4105E82 cytochrome subunit of dehydrogenase GH768_RS12285 ENOG4105TDT uncharacterized protein yahO GH768_RS12290 ENOG4108JU7 Transcriptional regulator GH768_RS12295 ENOG4105CR4 methylisocitrate lyase GH768_RS12300 ENOG4105BZN citrate synthase GH768_RS12305 ENOG4105DXD 2-methylcitrate dehydratase GH768_RS12310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GH768_RS12315 ENOG4105D52 delta-aminolevulinic acid dehydratase GH768_RS12320 ENOG4108NSE outer membrane autotransporter barrel GH768_RS12325 ENOG4108PNB DNA-binding transcriptional regulator GH768_RS12330 ENOG4107R6D beta-lactam binding protein AmpH GH768_RS12335 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 GH768_RS12340 ENOG4107QS8 (LipO)protein GH768_RS12345 ENOG4105FR5 inner membrane protein YaiY GH768_RS12350 ENOG4105UNH Membrane GH768_RS12355 ENOG4105CPF Cell wall formation (By similarity) GH768_RS12370 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) GH768_RS12375 ENOG4105VIF phosphate starvation-inducible protein GH768_RS12380 ENOG4105BZU Histidine kinase GH768_RS12385 ENOG4105II7 pyrroline-5-carboxylate reductase GH768_RS12400 ENOG4105SS3 GH768_RS12405 ENOG4105HBA AroM protein GH768_RS12420 ENOG4105DKQ ROK family GH768_RS12425 ENOG4105F27 Major Facilitator GH768_RS12430 ENOG4105EYH Exonuclease GH768_RS12435 ENOG4107RH8 nuclease SbcCD subunit D GH768_RS12440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH768_RS12445 ENOG4105BZU Histidine kinase GH768_RS12450 ENOG4105CWM branched-chain amino acid transport system II carrier protein GH768_RS12455 ENOG4105C85 amino acid GH768_RS12460 ENOG4107R28 alpha amylase, catalytic region GH768_RS12465 ENOG4105D3R alkyl hydroperoxide reductase GH768_RS12485 ENOG4105VIE preprotein translocase, subunit YajC GH768_RS12495 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GH768_RS12500 ENOG4105N1F Hnh endonuclease GH768_RS12505 ENOG4105DRB nucleoside-specific channel-forming protein GH768_RS12510 ENOG4108KIC (LipO)protein GH768_RS12520 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GH768_RS12530 ENOG4107YIM Involved in the transcription termination process (By similarity) GH768_RS12535 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GH768_RS12540 ENOG4108ZAI phosphatidylglycerophosphatase a GH768_RS12545 ENOG4105CPC Aldo Keto reductase GH768_RS12555 ENOG4105CTB Polyprenyl synthetase GH768_RS12560 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GH768_RS12570 ENOG4107S0N DJ-1 family GH768_RS12575 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GH768_RS12585 ENOG4107RDB Major Facilitator GH768_RS12600 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GH768_RS12605 ENOG4105CCU oxidase (Subunit III) GH768_RS12610 ENOG4105BZ9 Cytochrome C oxidase, subunit I GH768_RS12615 ENOG4105E2S oxidase) subunit II GH768_RS12620 ENOG4105EYM Major Facilitator superfamily GH768_RS12625 ENOG4105IEY (LipO)protein GH768_RS12630 ENOG4105M85 Bola protein GH768_RS12645 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GH768_RS12650 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GH768_RS12655 ENOG4105K70 DNA-binding protein GH768_RS12660 ENOG4105EIN peptidylprolyl cis-trans isomerase GH768_RS12665 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GH768_RS12670 ENOG4108TGP Thioesterase superfamily protein GH768_RS12680 ENOG4108NFA extracellular solute-binding protein GH768_RS12685 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) GH768_RS12695 ENOG4108XM1 transcriptional regulator AsnC family GH768_RS12700 ENOG4105BZ1 (ABC) transporter GH768_RS12705 ENOG4105BZ1 (ABC) transporter GH768_RS12710 ENOG4108YZA Nitrogen regulatory protein pii GH768_RS12715 ENOG4105BZU Histidine kinase GH768_RS12720 ENOG4105C29 acyl-CoA thioesterase GH768_RS12725 ENOG4108MNP Glycoprotein polysaccharide metabolism GH768_RS12730 ENOG41080UX Methyltransferase GH768_RS12740 ENOG41066DG (EAL) domain protein GH768_RS12755 ENOG4105GSJ Inner membrane protein ylaC GH768_RS12760 ENOG4108UW5 maltose o-acetyltransferase GH768_RS12770 ENOG4108UKR Biofilm formation regulator YbaJ GH768_RS12775 ENOG4105BZS acriflavin resistance protein GH768_RS12780 ENOG4105C1P efflux transporter, rnd family, mfp subunit GH768_RS12785 ENOG4107XI7 Tetr family transcriptional regulator GH768_RS12790 ENOG4105EGS Mechanosensitive ion channel GH768_RS12820 ENOG4106428 Protein of unknown function (DUF2496) GH768_RS12825 ENOG4108URS primosomal replication protein n'' GH768_RS12830 ENOG4105WD1 Membrane GH768_RS12840 ENOG4107QMP dna polymerase iii subunits gamma and tau GH768_RS12875 ENOG4107RE1 Inosine-guanosine kinase GH768_RS12880 ENOG4105CKD glutathione-regulated potassium-efflux system protein GH768_RS12885 ENOG4105EU0 Major facilitator Superfamily GH768_RS12890 ENOG4105CGH 5'-nucleotidase GH768_RS12895 ENOG4108Z66 YbaK ebsC protein GH768_RS12900 ENOG4105MBR gumn family GH768_RS12905 ENOG4105C59 p-type ATPase GH768_RS12910 ENOG4108Z6Z Transcriptional regulator GH768_RS12915 ENOG4105G5H Membrane GH768_RS12920 ENOG4107QX8 SPFH domain, Band 7 family protein GH768_RS12925 ENOG41083J0 (ABC) transporter GH768_RS12930 ENOG4105C4B ABC transporter, permease GH768_RS12935 ENOG4107QR8 Thioredoxin GH768_RS12940 ENOG4105E1F short-chain dehydrogenase reductase GH768_RS12945 ENOG4108UJV acyl-CoA thioesterase i GH768_RS12950 ENOG4108I0Y (ABC) transporter GH768_RS12955 ENOG4105CV6 ABC transporter, permease GH768_RS12965 ENOG4105GMB type VI secretion system effector, hcp1 family GH768_RS12980 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GH768_RS12985 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GH768_RS12995 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GH768_RS13000 ENOG4105C8N cysteinyl-tRNA synthetase GH768_RS13005 ENOG4105WQ3 Rna-binding protein GH768_RS13015 ENOG4108WDE Fimbrial protein GH768_RS13025 ENOG4108AF8 Chaperone GH768_RS13030 ENOG4105CW0 outer membrane usher protein GH768_RS13035 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) GH768_RS13040 ENOG4108ZI2 Fimbrial protein GH768_RS13045 ENOG4108Q9V regulatoR GH768_RS13050 ENOG4106721 fimbriae Y protein GH768_RS13060 ENOG4106KCD HTH_LUXR GH768_RS13095 ENOG4105EQR Transposase IS116 IS110 IS902 GH768_RS13110 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 GH768_RS13115 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) GH768_RS13140 ENOG4108IJF Heavy metal efflux pump, CzcA GH768_RS13145 ENOG4108K01 transcriptional regulator GH768_RS13150 ENOG4107QN2 dihydrolipoyl dehydrogenase GH768_RS13155 ENOG41066GK UPF0379 protein ykgI GH768_RS13160 ENOG4108KBJ Inner membrane protein YkgB GH768_RS13170 ENOG4105C85 amino acid GH768_RS13175 ENOG4105CUY Mechanosensitive ion channel GH768_RS13185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH768_RS13190 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine GH768_RS13200 ENOG4105F3R pts system mannose fructose sorbose family iid GH768_RS13220 ENOG4108RCM Nitroreductase GH768_RS13225 ENOG4105MSB protein, conserved in bacteria GH768_RS13230 ENOG41067SE Tetr family transcriptional regulator GH768_RS13235 ENOG4105HFT AraC family transcriptional regulator GH768_RS13240 ENOG4105WQ6 Membrane GH768_RS13250 ENOG4108TSE Transferase GH768_RS13255 ENOG4107RNH Outer membrane receptor FepA GH768_RS13260 ENOG4105E93 esterase GH768_RS13265 ENOG41085A6 mbth domain-containing protein GH768_RS13270 ENOG4105C0W non-ribosomal peptide synthetase GH768_RS13275 ENOG4108QY5 Ferric enterobactin transport protein GH768_RS13280 ENOG4105E0A ABC, transporter GH768_RS13285 ENOG4105TVJ transport system, permease GH768_RS13290 ENOG4105DQ5 transport system permease protein GH768_RS13295 ENOG4105E8G Major facilitator Superfamily GH768_RS13300 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GH768_RS13305 ENOG4105E4F Isochorismate synthase GH768_RS13310 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GH768_RS13315 ENOG4105WQI isochorismatase GH768_RS13320 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GH768_RS13330 ENOG4105D22 carbon starvation protein GH768_RS13335 ENOG4105VCD cytoplasmic protein GH768_RS13340 ENOG4107SCQ Iron-containing alcohol dehydrogenase GH768_RS13345 ENOG4105CHM Aminotransferase GH768_RS13350 ENOG4105GTN ParB Domain Protein Nuclease GH768_RS13355 ENOG4105BZV Phosphoadenosine phosphosulfate reductase GH768_RS13360 ENOG4105DQS Transcriptional regulator GH768_RS13365 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase GH768_RS13370 ENOG4105D3R alkyl hydroperoxide reductase GH768_RS13375 ENOG4108JU3 Alkyl hydroperoxide reductase GH768_RS13380 ENOG4108U51 Universal stress protein GH768_RS13385 ENOG4105E2A Dehydrogenase GH768_RS13390 ENOG4105NXH GreA GreB family elongation factor GH768_RS13395 ENOG4105KTS ribonuclease GH768_RS13400 ENOG4107QPK )-transporter GH768_RS13410 ENOG4105YGP holo-ACP synthase CitX GH768_RS13415 ENOG4105CHY citrate lyase, alpha GH768_RS13420 ENOG4105CI0 Citrate lyase GH768_RS13425 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) GH768_RS13430 ENOG4105DUA (citrate (pro-3S)-lyase ligase GH768_RS13435 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GH768_RS13440 ENOG4106YYS transcriptional regulatory protein GH768_RS13445 ENOG4105CEE C4-dicarboxylate transporter GH768_RS13460 ENOG4107Z6W Protein CrcB homolog GH768_RS13480 ENOG41064T2 transcriptional regulator, lysR family GH768_RS13490 ENOG4108Z43 UPF0250 protein GH768_RS13495 ENOG4105DZ1 carboxypeptidase GH768_RS13500 ENOG4105K6T rare lipoprotein A GH768_RS13505 ENOG4105CNI cell division protein FtsW GH768_RS13510 ENOG4105CJN penicillin-binding protein GH768_RS13515 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GH768_RS13520 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GH768_RS13535 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GH768_RS13540 ENOG4105DJF DNA polymerase III, delta' subunit GH768_RS13550 ENOG4105C8T Leucyl-tRNA synthetase GH768_RS13555 ENOG4107PAI alpha helical protein GH768_RS13560 ENOG4105DU0 nucleoside hydrolase GH768_RS13565 ENOG4105CDA abc transporter atp-binding protein GH768_RS13570 ENOG4105DRP amino acid AbC transporter GH768_RS13575 ENOG4105EAD ABC transporter GH768_RS13580 ENOG4107RP9 extracellular solute-binding protein, family 3 GH768_RS13585 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GH768_RS13590 ENOG4108JU5 Magnesium and cobalt efflux protein GH768_RS13600 ENOG4105C9A Phoh family GH768_RS13610 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GH768_RS13650 ENOG4105CAQ asparagine synthetase GH768_RS13655 ENOG4105D4U had-superfamily hydrolase, subfamily iia GH768_RS13660 ENOG4105E2R ROK family GH768_RS13665 ENOG4105CE4 GlcNAc 6-P deacetylase GH768_RS13675 ENOG4105CI1 PTS System GH768_RS13685 ENOG4105J5J Outer membrane porin GH768_RS13690 ENOG4105GX6 (LipO)protein GH768_RS13695 ENOG4105CSH Transporter GH768_RS13700 ENOG41079YP Citrate utilization protein b GH768_RS13705 ENOG4107EFR Flavocytochrome c GH768_RS13710 ENOG4106P55 Transcriptional regulator GH768_RS13715 ENOG41090R7 Ferric uptake GH768_RS13720 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GH768_RS13725 ENOG4105NNH LexA regulated protein GH768_RS13730 ENOG4105EV9 Alpha Beta Hydrolase GH768_RS13735 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GH768_RS13740 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GH768_RS13750 ENOG4105D5Q Arginine ornithine antiporter GH768_RS13755 ENOG4105CXN decarboxylase GH768_RS13765 ENOG4105EEX Two component transcriptional regulator (Winged helix family GH768_RS13770 ENOG4105C08 Histidine kinase GH768_RS13780 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GH768_RS13795 ENOG4105XIQ Protein of unknown function (DUF2517) GH768_RS13800 ENOG4105GMB type VI secretion system effector, hcp1 family GH768_RS13820 ENOG4105CVP deoxyribo-dipyrimidine photolyase GH768_RS13830 ENOG4107QNR UPF0135 protein GH768_RS13835 ENOG4105P4J Allophanate hydrolase, subunit 1 GH768_RS13840 ENOG4107R7A Allophanate hydrolase subunit 2 GH768_RS13855 ENOG4108W9T type 1 fimbriae regulatory protein GH768_RS13920 ENOG4108KK1 membrane protein AbrB duplication GH768_RS13925 ENOG4105BZN citrate synthase GH768_RS13935 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GH768_RS13940 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GH768_RS13945 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GH768_RS13950 ENOG4105E33 succinate dehydrogenase GH768_RS13955 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GH768_RS13960 ENOG4105C7S Dehydrogenase GH768_RS13970 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GH768_RS13975 ENOG4105C4M (Ubiquinol oxidase) subunit I GH768_RS13980 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GH768_RS13990 ENOG4105KJB cyd operon protein YbgE GH768_RS13995 ENOG4107YD3 Thioesterase GH768_RS14000 ENOG4105E02 MotA TolQ exbB proton channel GH768_RS14010 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GH768_RS14010 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GH768_RS14020 ENOG4105KCK Peptidoglycan-associated lipoprotein GH768_RS14025 ENOG4105UFD tol-pal system protein YbgF GH768_RS14060 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GH768_RS14065 ENOG4105PGM cation diffusion facilitator family transporter GH768_RS14070 ENOG4105JND homeobox protein GH768_RS14075 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GH768_RS14080 ENOG4105EHG Permease protein GH768_RS14085 ENOG4105E0A ABC, transporter GH768_RS14095 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GH768_RS14105 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GH768_RS14110 ENOG4105CMR udp-glucose 4-epimerase GH768_RS14115 ENOG4105DKW ABC transporter GH768_RS14120 ENOG4105F4R Transcriptional regulator mode GH768_RS14130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GH768_RS14135 ENOG4105E0C molybdate abc transporter GH768_RS14145 ENOG4108K4B hydrolase GH768_RS14160 ENOG4105NBR Pectinesterase GH768_RS14180 ENOG4105CGP Urocanate hydratase GH768_RS14185 ENOG4105C84 Histidine ammonia-lyase GH768_RS14190 ENOG4108V1U phospholipid-binding protein GH768_RS14195 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GH768_RS14210 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GH768_RS14215 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GH768_RS14235 ENOG4105CHW UPF0052 protein GH768_RS14245 ENOG4108RIR Molybdenum cofactor biosynthesis protein GH768_RS14255 ENOG4105M00 molybdopterin converting factor, subunit 1 GH768_RS14260 ENOG4108ZAF Molybdopterin GH768_RS14265 ENOG4105HFZ Membrane GH768_RS14270 ENOG4107UXM Membrane GH768_RS14275 ENOG4105DZQ phospholipase D Transphosphatidylase GH768_RS14280 ENOG4105X23 Endonuclease Exonuclease phosphatase GH768_RS14285 ENOG4105I9U inner membrane protein ybhQ GH768_RS14290 ENOG4107QWP ABC-2 type transporter GH768_RS14295 ENOG4107QWP ABC-2 type transporter GH768_RS14300 ENOG4105CJ1 ABC, transporter GH768_RS14310 ENOG4107MVR Transcriptional regulator GH768_RS14315 ENOG4105C1J atp-dependent rna helicase GH768_RS14320 ENOG4105DVT helicase GH768_RS14325 ENOG4108MTB glycosyl transferase family GH768_RS14330 ENOG4105VR4 UPF0379 protein ybiJ GH768_RS14335 ENOG4105KSC Transcriptional regulator, TraR DksA family GH768_RS14345 ENOG4105D8X mechanosensitive ion channel GH768_RS14350 ENOG4105CDA abc transporter atp-binding protein GH768_RS14355 ENOG4105E5Q amino acid AbC transporter GH768_RS14360 ENOG4107R0W ABC transporter GH768_RS14375 ENOG4108T1M outer membrane protein x GH768_RS14380 ENOG4108I6E Sulfatase GH768_RS14390 ENOG4105KST dependent repressor GH768_RS14395 ENOG4105F4P )-transporter GH768_RS14400 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH768_RS14405 ENOG4105C5H ABC transporter GH768_RS14415 ENOG4105DPW Major facilitator superfamily MFS_1 GH768_RS14425 ENOG41072TH Protein of unknown function (DUF1479) GH768_RS14430 ENOG4108HCJ Hydrolase GH768_RS14440 ENOG4105F1A Pyruvate formate-lyase GH768_RS14445 ENOG4105D06 uba thif-type nad fad binding protein GH768_RS14450 ENOG4105CVM Molybdenum cofactor synthesis domain protein GH768_RS14455 ENOG4105D44 asparaginase GH768_RS14460 ENOG4108JQ6 ABC transporter GH768_RS14465 ENOG4105DEF Extracellular solute-binding protein, family 5 GH768_RS14485 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway GH768_RS14490 ENOG4105CI0 Citrate lyase GH768_RS14495 ENOG4105BZJ Electron transfer flavoprotein GH768_RS14500 ENOG4105C10 Electron transfer flavoprotein GH768_RS14510 ENOG4105C1G acyl-Coa dehydrogenase GH768_RS14515 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GH768_RS14520 ENOG4108KB2 LysR family Transcriptional regulator GH768_RS14525 ENOG4105CY2 Citrate transporter GH768_RS14535 ENOG4108TGY Glutathione S-transferase GH768_RS14540 ENOG4105DZ1 carboxypeptidase GH768_RS14545 ENOG4107FB0 transcriptional regulator DeoR family GH768_RS14550 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GH768_RS14555 ENOG4107QF7 multi-drug GH768_RS14560 ENOG4108HCJ Hydrolase GH768_RS14565 ENOG4106UW1 Major Facilitator superfamily GH768_RS14570 ENOG4108RFG Tetr family transcriptional regulator GH768_RS14580 ENOG4105GWF inner membrane protein YbjM GH768_RS14585 ENOG41090BQ Glutaredoxin GH768_RS14590 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress GH768_RS14595 ENOG4108DBC nitroreductase GH768_RS14605 ENOG4108RMJ sensory transduction regulator GH768_RS14610 ENOG4107RUE extracellular solute-binding protein family 1 GH768_RS14615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH768_RS14620 ENOG4105F38 ABC transporter, permease GH768_RS14625 ENOG4105D38 putrescine abc transporter GH768_RS14630 ENOG4105RBQ inner membrane protein ybjO GH768_RS14655 ENOG4106TNF Periplasmic binding protein GH768_RS14660 ENOG4105DMR ABC, transporter GH768_RS14665 ENOG4105GBT ABC transporter GH768_RS14670 ENOG4106PMH Extracellular solute-binding protein family 3 GH768_RS14675 ENOG4105E5Z arginine transporter ATP-binding subunit GH768_RS14680 ENOG41064MM (LipO)protein GH768_RS14735 ENOG4108RS6 transposase GH768_RS14780 ENOG4105EQR Transposase IS116 IS110 IS902 GH768_RS14825 ENOG4105NVB glycoside hydrolase, family 19 GH768_RS14855 ENOG4105Y50 Virulence Protein GH768_RS14865 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GH768_RS14870 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GH768_RS14875 ENOG4105CGD Nad-dependent epimerase dehydratase GH768_RS14880 ENOG4105C5W Aldolase GH768_RS14885 ENOG4105C7K acetolactate synthase GH768_RS14890 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GH768_RS14900 ENOG4105DWU Membrane GH768_RS14905 ENOG4105CPB ATP-dependent endonuclease of the OLD family GH768_RS14910 ENOG4108MJ5 VirK protein GH768_RS14915 ENOG4105DJY efflux transporter, rnd family, mfp subunit GH768_RS14920 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GH768_RS14925 ENOG4105VEQ Cold shock protein GH768_RS14935 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GH768_RS14945 ENOG4105CHJ isochorismatase hydrolase GH768_RS14950 ENOG4105EUB pirin domain protein GH768_RS14955 ENOG4105HEI LysR family (Transcriptional regulator GH768_RS14960 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GH768_RS14975 ENOG4108JJ8 (ABC) transporter GH768_RS14980 ENOG4108JJ9 ABC, transporter GH768_RS14985 ENOG4105C3M thioredoxin reductase GH768_RS14990 ENOG4105EW9 transcriptional regulator AsnC family GH768_RS14995 ENOG4105CNU cell division protein FtsK GH768_RS15005 ENOG4105D1H recombination factor protein RarA GH768_RS15015 ENOG4107QY8 reductase GH768_RS15020 ENOG4105QAX Iron-sulfur GH768_RS15025 ENOG4107KGK dmso reductase anchor subunit GH768_RS15030 ENOG4105CHJ isochorismatase hydrolase GH768_RS15050 ENOG4105E5D amino acid GH768_RS15060 ENOG4105F1A Pyruvate formate-lyase GH768_RS15065 ENOG4105GUS GH768_RS15070 ENOG4105C6N Formate acetyltransferase GH768_RS15075 ENOG4105TMB Formate nitrite transporter GH768_RS15080 ENOG4105DDY UPF0142 protein ycaO GH768_RS15085 ENOG4107VMU Membrane GH768_RS15100 ENOG4108K0D peptidase, M48 GH768_RS15110 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GH768_RS15115 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GH768_RS15120 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GH768_RS15125 ENOG4105BZ1 (ABC) transporter GH768_RS15130 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GH768_RS15135 ENOG4105T0Z Conserved Protein GH768_RS15140 ENOG4105W49 UPF0434 protein GH768_RS15150 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups GH768_RS15155 ENOG4107S90 membrAne GH768_RS15160 ENOG4106371 Methyltransferase GH768_RS15170 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GH768_RS15180 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GH768_RS15185 ENOG4105EAQ (twin-arginine translocation) pathway signal GH768_RS15190 ENOG4105C5X domain protein GH768_RS15195 ENOG4105CGF Aromatic amino acid aminotransferase GH768_RS15200 ENOG4105FCK Membrane GH768_RS15205 ENOG4105C5S asparaginyl-tRNA synthetase GH768_RS15215 ENOG4105CD8 aminopeptidase N GH768_RS15225 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GH768_RS15240 ENOG4105C5H ABC transporter GH768_RS15245 ENOG4105F1S paraquat-inducible protein a GH768_RS15250 ENOG4105DY2 Paraquat-inducible protein b GH768_RS15255 ENOG4108Q2G (LipO)protein GH768_RS15260 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) GH768_RS15265 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GH768_RS15270 ENOG4105DAN ATP-dependent protease GH768_RS15280 ENOG4105UYK outer membrane protein a GH768_RS15285 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) GH768_RS15290 ENOG4108RZ1 DNA transformation protein GH768_RS15295 ENOG4105EM2 membrane GH768_RS15300 ENOG410901E Membrane GH768_RS15305 ENOG41088T4 Helicase IV GH768_RS15310 ENOG4108Z5K methylglyoxal synthase GH768_RS15320 ENOG4105K4P CoA-binding domain protein GH768_RS15340 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GH768_RS15350 ENOG4108MN8 Membrane GH768_RS15365 ENOG4108SEH involved in lipopolysaccharide biosynthesis GH768_RS15375 ENOG4105CSV Glutaminase GH768_RS15385 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GH768_RS15390 ENOG4105CVK Glutamate decarboxylase GH768_RS15415 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase GH768_RS15425 ENOG4106HNN Invasion protein GH768_RS15430 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell GH768_RS15450 ENOG4106YSC GH768_RS15465 ENOG4107ZY3 Histidine kinase GH768_RS15470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH768_RS15475 ENOG4105VT2 5-hydroxyisourate hydrolase GH768_RS15480 ENOG4107UWN reductase GH768_RS15485 ENOG4105EFA 4-hydroxyphenylacetate GH768_RS15490 ENOG4108V8F Transcriptional regulator, MarR family GH768_RS15500 ENOG4105C26 Dehydrogenase GH768_RS15505 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase GH768_RS15560 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GH768_RS15565 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GH768_RS15570 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GH768_RS15575 ENOG4105D6F Phosphatase GH768_RS15580 ENOG4105XH3 GH768_RS15585 ENOG4105CS1 NAD(P)H quinone oxidoreductase GH768_RS15590 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 GH768_RS15595 ENOG4108R86 Transcriptional regulator GH768_RS15610 ENOG4105CK7 Sodium proline symporter GH768_RS15615 ENOG4105D5M phosphate starvation-inducible protein GH768_RS15620 ENOG4105QEK Transcriptional regulator GH768_RS15625 ENOG4107RJ1 sodium solute GH768_RS15645 ENOG4108QGT oligogalacturonate-specific porin GH768_RS15650 ENOG4105JHE Major Facilitator Superfamily GH768_RS15655 ENOG4107RJ5 oxidoreductase GH768_RS15685 ENOG4107XHZ cytoplasmic chaperone TorD family protein GH768_RS15690 ENOG4108UQ5 membrane protein YcdZ GH768_RS15695 ENOG4105P8Q Curli production assembly transport component CsgG GH768_RS15700 ENOG4108WYR Curli production assembly transport component, CsgF GH768_RS15705 ENOG4108XDW curli assembly protein CsgE GH768_RS15710 ENOG41086KC Transcriptional regulator GH768_RS15715 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers GH768_RS15720 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin GH768_RS15725 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) GH768_RS15730 ENOG41068SS GH768_RS15735 ENOG4108UVJ appr-1-p processing domain protein GH768_RS15740 ENOG4107RZC phospholipase d GH768_RS15755 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) GH768_RS15760 ENOG4105NAC (LipO)protein GH768_RS15765 ENOG4108W47 Acidic protein msyB GH768_RS15775 ENOG4105D1S lipid A biosynthesis GH768_RS15785 ENOG4108YYC ycei family GH768_RS15790 ENOG4105DS1 cytochrome b561 GH768_RS15795 ENOG4106974 biofilm formation GH768_RS15805 ENOG4105PVA Biofilm formation regulatory protein BssS GH768_RS15810 ENOG4105MEA DNA damage-inducible protein i GH768_RS15815 ENOG4105EKE dihydroorotase GH768_RS15820 ENOG4105F3T (LipO)protein GH768_RS15825 ENOG4105E9S glutaredoxin 2 GH768_RS15835 ENOG4105D9U N-acetyltransferase GH768_RS15845 ENOG4105EP9 oxidoreductase GH768_RS15850 ENOG4105CJR Integral membrane protein (MviN GH768_RS15855 ENOG4105QVD Flagella synthesis protein FlgN GH768_RS15860 ENOG4105M9M anti-sigma28 factor FlgM GH768_RS15865 ENOG4105CKS Flagella basal body P-ring formation protein flgA GH768_RS15870 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GH768_RS15875 ENOG4108ZC9 flagellar basal-body rod protein flgc GH768_RS15880 ENOG4105W00 Flagellar hook capping protein GH768_RS15885 ENOG4105BZE flagellar hook protein, FlgE GH768_RS15890 ENOG4108KPB Flagellar basal-body rod protein FlgF GH768_RS15895 ENOG4105CGA flagellar basal-body rod protein FlgG GH768_RS15910 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GH768_RS15915 ENOG4105E1Q flagellar hook-associated protein GH768_RS15920 ENOG4105DTJ flagellar hook-associated protein GH768_RS15925 ENOG4107QQB Ribonuclease E GH768_RS15930 ENOG4105EI2 Pseudouridine synthase GH768_RS15940 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GH768_RS15960 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GH768_RS15965 ENOG4105CHR reductase GH768_RS15970 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GH768_RS15975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GH768_RS15995 ENOG4105CW0 outer membrane usher protein GH768_RS16005 ENOG4106EAR Fimbrial protein GH768_RS16010 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GH768_RS16015 ENOG4105HHA aminodeoxychorismate lyase GH768_RS16025 ENOG4107QRG dna polymerase iii GH768_RS16030 ENOG4105F8V Hydrolase, tatD family GH768_RS16035 ENOG4105CI1 PTS System GH768_RS16040 ENOG4105CNM Receptor GH768_RS16045 ENOG4105K59 histidine triad (HIT) protein GH768_RS16050 ENOG41090DQ Lipoprotein GH768_RS16055 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) GH768_RS16070 ENOG4105D0Y UPF0227 protein GH768_RS16075 ENOG4105CEP NADH dehydrogenase GH768_RS16080 ENOG4107MBR 17 kDa surface antigen GH768_RS16085 ENOG4108IND Tetr family transcriptional regulator GH768_RS16090 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction GH768_RS16095 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH768_RS16100 ENOG4108JA2 transcriptioN-repair coupling factor GH768_RS16105 ENOG4105D60 lipoprotein releasing system transmembrane protein GH768_RS16110 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GH768_RS16115 ENOG4105D60 lipoprotein releasing system transmembrane protein GH768_RS16125 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GH768_RS16130 ENOG4108HM4 ABC transporter GH768_RS16135 ENOG4105D38 putrescine abc transporter GH768_RS16160 ENOG4105EZE Cupin 4 family protein GH768_RS16175 ENOG4107QTF adenylosuccinate lyase GH768_RS16200 ENOG4108R99 pseudouridine synthase GH768_RS16205 ENOG4108HMX isocitrate dehydrogenase (NADP) GH768_RS16210 ENOG4108I1J Integrase GH768_RS16250 ENOG4105QYK bacteriophage lambda Bor protein homolog GH768_RS16255 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium GH768_RS16270 ENOG4105Y50 Virulence Protein GH768_RS16275 ENOG4106F2Y RICIN GH768_RS16280 ENOG41060EU Cold shock-like protein GH768_RS16290 ENOG4105H38 Membrane GH768_RS16315 ENOG4108ZNX Heat shock protein GH768_RS16325 ENOG4108VKM cytochrome b561 GH768_RS16335 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GH768_RS16340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH768_RS16350 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GH768_RS16355 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GH768_RS16360 ENOG4105D64 Mechanosensitive ion channel GH768_RS16375 ENOG4108MEK Metal-binding protein YodA GH768_RS16390 ENOG4108Z6Z Transcriptional regulator GH768_RS16400 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) GH768_RS16410 ENOG4108YS1 cytoplasmic protein GH768_RS16415 ENOG4105YP6 Domain of unknown function (DUF1869) GH768_RS16425 ENOG4105Y3U Transglycosylase-associated protein GH768_RS16430 ENOG4106G4W GH768_RS16435 ENOG4105UCG Domain of unknown function (DUF333) GH768_RS16445 ENOG4105K78 MarR family Transcriptional regulator GH768_RS16450 ENOG4105DJ2 Major Facilitator Superfamily GH768_RS16455 ENOG4105R1U AraC Family Transcriptional Regulator GH768_RS16470 ENOG4108KXH Ybak prolyl-tRNA synthetase associated GH768_RS16475 ENOG4108KHP Diguanylate cyclase GH768_RS16485 ENOG4105CYN Serine protein kinase GH768_RS16490 ENOG4105GNX MltA-interacting MipA family protein GH768_RS16495 ENOG4105C4X radical SAM domain protein GH768_RS16500 ENOG4105DSB aldose 1-epimerase GH768_RS16505 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GH768_RS16515 ENOG4105VUT cytoplasmic protein GH768_RS16520 ENOG4108RWI nicotinamidase GH768_RS16525 ENOG4105HDK L-asparaginase GH768_RS16530 ENOG4105D07 Signal peptide peptidase, SppA GH768_RS16535 ENOG41069NU Nitroreductase GH768_RS16540 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GH768_RS16545 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GH768_RS16550 ENOG4105D82 Glutamate dehydrogenase GH768_RS16555 ENOG4105MTM Protein of unknown function (DUF1496) GH768_RS16560 ENOG4105M6F mutator MutT protein GH768_RS16565 ENOG4105CGK Exodeoxyribonuclease III GH768_RS16595 ENOG4108SPG Periplasmic Protein GH768_RS16600 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) GH768_RS16610 ENOG4105KKI DNA-binding transcriptional activator OsmE GH768_RS16615 ENOG4105VZJ PTS System GH768_RS16620 ENOG4105CK1 PTS System GH768_RS16625 ENOG4105VCP PTS System GH768_RS16630 ENOG4105EZV Transcriptional regulator GH768_RS16635 ENOG4105F8D glycoside hydrolase family 4 GH768_RS16645 ENOG4105CH6 catalase GH768_RS16650 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) GH768_RS16655 ENOG4108ETY sodium dicarboxylate symporter GH768_RS16660 ENOG4107K5X Membrane-bound metal-dependent hydrolase GH768_RS16665 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GH768_RS16670 ENOG4107PN8 YfeABCD locus regulator GH768_RS16680 ENOG4105P10 Uncharacterized protein ydiZ GH768_RS16685 ENOG4105DE4 1-phosphofructokinase GH768_RS16690 ENOG4108NE3 Salt-induced outer membrane protein GH768_RS16720 ENOG4105KT5 UmuD protein GH768_RS16735 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GH768_RS16740 ENOG41082NX 50s ribosomal protein l35 GH768_RS16760 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GH768_RS16765 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GH768_RS16775 ENOG4108V06 Glutathione peroxidase GH768_RS16785 ENOG4108QBX (LipO)protein GH768_RS16795 ENOG4105CNG UPF0061 protein GH768_RS16805 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GH768_RS16815 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GH768_RS16820 ENOG4105CEY Amp-dependent synthetase and ligase GH768_RS16825 ENOG41090P5 ferredoxin-like protein GH768_RS16830 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GH768_RS16835 ENOG4105C10 Electron transfer flavoprotein GH768_RS16840 ENOG4105CV7 Electron transfer flavoprotein GH768_RS16845 ENOG4105W4W Transcriptional regulator GH768_RS16850 ENOG4105C1G acyl-Coa dehydrogenase GH768_RS16855 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) GH768_RS16860 ENOG4105FF2 Type I DHQase GH768_RS16870 ENOG4105EMV Major Facilitator GH768_RS16875 ENOG4105EMV Major Facilitator GH768_RS16880 ENOG4105SUA Ydil protein GH768_RS16890 ENOG4105IPI Membrane GH768_RS16895 ENOG4105CQB FAD linked oxidase domain protein GH768_RS16900 ENOG4105KA0 thioesterase Superfamily protein GH768_RS16905 ENOG410671Z uncharacterized protein ydiH GH768_RS16910 ENOG4108ETY sodium dicarboxylate symporter GH768_RS16915 ENOG4108Z4V iron-sulfur cluster assembly GH768_RS16920 ENOG4105DIW FeS assembly protein SUFB GH768_RS16925 ENOG4105C3K feS assembly ATPase SufC GH768_RS16930 ENOG4105JRK feS assembly protein SufD GH768_RS16945 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH768_RS16955 ENOG4105CA9 Pyruvate kinase GH768_RS16965 ENOG4105DB1 molybdopterin oxidoreductase GH768_RS16970 ENOG4106WHD Tetrathionate reductase GH768_RS16975 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GH768_RS16980 ENOG4106AFQ Histidine kinase GH768_RS16985 ENOG4108ZXC Two component transcriptional regulator, luxr family GH768_RS16990 ENOG4105RFR Protein of unknown function (DUF2767) GH768_RS16995 ENOG4107SEY Conserved Protein GH768_RS17000 ENOG4108XDN Transcriptional regulator GH768_RS17010 ENOG4105BZU Histidine kinase GH768_RS17040 ENOG4105ZQI secreted protein GH768_RS17050 ENOG4108SZ7 secretion system effector GH768_RS17055 ENOG4106FZW pathogenicity island effector protein GH768_RS17105 ENOG4106563 type III secretion system apparatus protein GH768_RS17110 ENOG4105UQF type iii secretion GH768_RS17115 ENOG4106H1D secretion system apparatus protein GH768_RS17125 ENOG4108JIR Flagellum-specific ATP synthase GH768_RS17140 ENOG41063Q7 Type III secretion system protein GH768_RS17145 ENOG4108HHI Type III secretion system protein GH768_RS17150 ENOG41083GP type iii secretion GH768_RS17155 ENOG4108TN6 type iii secretion GH768_RS17160 ENOG4108IUF type iii secretion GH768_RS17185 ENOG4108R6K riboflavin synthase, subunit alpha GH768_RS17190 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GH768_RS17195 ENOG4105CZQ inner membrane transport protein YdhC GH768_RS17200 ENOG4105F52 Transcriptional regulator GH768_RS17215 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GH768_RS17220 ENOG4105K4H Nlp p60 protein GH768_RS17225 ENOG4105M2J Glutaredoxin GH768_RS17230 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GH768_RS17235 ENOG4108UYE Lactoylglutathione lyase GH768_RS17240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GH768_RS17245 ENOG4108WUH Transcriptional regulator, TetR family GH768_RS17250 ENOG4105XZD Fe-S protein GH768_RS17255 ENOG4107RGM aldo keto reductase GH768_RS17260 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GH768_RS17265 ENOG4105DSW Fusaric acid resistance protein GH768_RS17270 ENOG4105Y49 secretion protein, HlyD family GH768_RS17285 ENOG4108XTF Outer Membrane Lipoprotein GH768_RS17295 ENOG410642K Lysozyme inhibitor GH768_RS17305 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GH768_RS17315 ENOG4108K3A Glutathione S-transferase GH768_RS17320 ENOG4105DUX Transporter GH768_RS17325 ENOG4105CSM endonuclease III GH768_RS17335 ENOG4108UQQ Electron transport complex GH768_RS17360 ENOG4105M9B inner membrane protein ydgK GH768_RS17370 ENOG4106C6R beta-lactam resistance protein GH768_RS17375 ENOG4105D9R oxidoreductase GH768_RS17385 ENOG4105C87 Aminotransferase class I and II GH768_RS17390 ENOG4105CI1 PTS System GH768_RS17395 ENOG4107P2S Transcriptional regulator GH768_RS17400 ENOG4106J39 exported protein GH768_RS17405 ENOG4105EIP mannose-6-phosphate isomerase GH768_RS17410 ENOG4107GFK fumarate GH768_RS17415 ENOG4105C9Q fumarate hydratase class II GH768_RS17425 ENOG4105JJR Histidine kinase GH768_RS17435 ENOG4105FCK Membrane GH768_RS17440 ENOG4107EXC regulatoR GH768_RS17445 ENOG4105RA2 Membrane GH768_RS17450 ENOG4105D5Q Arginine ornithine antiporter GH768_RS17455 ENOG4105C5D exported protein GH768_RS17460 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GH768_RS17465 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GH768_RS17470 ENOG4105DSF transport protein GH768_RS17490 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap GH768_RS17500 ENOG4105D94 Major Facilitator Superfamily GH768_RS17505 ENOG4106NZI LysR family Transcriptional regulator GH768_RS17510 ENOG4105DAG ROK family GH768_RS17515 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GH768_RS17525 ENOG4108IJ8 ABC transporter GH768_RS17530 ENOG4105E90 ABC transporter GH768_RS17535 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GH768_RS17540 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component GH768_RS17545 ENOG4108NEM leader-binding protein dmsD GH768_RS17550 ENOG4107KGK dmso reductase anchor subunit GH768_RS17555 ENOG4105QAX Iron-sulfur GH768_RS17560 ENOG4105C3J Cysteine desulfurase GH768_RS17565 ENOG4107QY8 reductase GH768_RS17570 ENOG4105KBG Protein of unknown function (DUF1161) GH768_RS17580 ENOG4108MK9 spermidine N(1)-acetyltransferase GH768_RS17600 ENOG4105D2H Uronic isomerase GH768_RS17610 ENOG4105DEI Mannitol dehydrogenase GH768_RS17615 ENOG41061EV selenium-binding protein YdfZ GH768_RS17620 ENOG4107XBN GntR Family Transcriptional Regulator GH768_RS17625 ENOG4105EMU Dehydrogenase GH768_RS17630 ENOG4105DGW oligopeptidase A GH768_RS17640 ENOG4108WTK competence damage-inducible protein GH768_RS17645 ENOG4108YDI single-species biofilm formation on inanimate substrate GH768_RS17655 ENOG4105E5W Transporter GH768_RS17660 ENOG4108594 Permease of the drug metabolite transporter GH768_RS17670 ENOG4108ZXC Two component transcriptional regulator, luxr family GH768_RS17675 ENOG4106DNR multiple antibiotic resistance protein GH768_RS17680 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF GH768_RS17685 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GH768_RS17700 ENOG4105EGI Transcriptional regulator GH768_RS17705 ENOG4105C26 Dehydrogenase GH768_RS17715 ENOG4105M0C cytoplasmic protein GH768_RS17725 ENOG4105FFC UPF0187 protein GH768_RS17750 ENOG4105MVP hydrogenase-1 operon protein HyaF GH768_RS17765 ENOG4108USZ hydrogenase GH768_RS17770 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit GH768_RS17775 ENOG4105DPX Hydrogenase, large subunit GH768_RS17790 ENOG4105C6F GntR Family Transcriptional Regulator GH768_RS17795 ENOG4105CPQ Dehydrogenase GH768_RS17800 ENOG4108I5G Major Facilitator superfamily GH768_RS17825 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GH768_RS17875 ENOG4105MQ5 zona occludens toxin GH768_RS17940 ENOG4105MQ5 zona occludens toxin GH768_RS17960 ENOG41060NJ transcriptional regulator GH768_RS17965 ENOG4105DFD Na H antiporter GH768_RS17970 ENOG4105C87 Aminotransferase class I and II GH768_RS17985 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GH768_RS17995 ENOG4105XXV Acid-resistance protein GH768_RS18000 ENOG4108Z9K Osmotically inducible protein GH768_RS18005 ENOG4105TPS biofilm-dependent modulation protein GH768_RS18015 ENOG4107R1I NAD-dependent malic enzyme GH768_RS18020 ENOG4105DQ4 alcohol dehydrogenase GH768_RS18025 ENOG4108MG3 formate dehydrogenase GH768_RS18030 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GH768_RS18065 ENOG4107QND Nitrite extrusion protein GH768_RS18070 ENOG4105CRU nitrate reductase, alpha subunit GH768_RS18075 ENOG4108IUE nitrate reductase beta subunit GH768_RS18080 ENOG4108NZN Respiratory nitrate reductase 2 delta chain GH768_RS18085 ENOG4105D0D Nitrate reductase 2, gamma subunit GH768_RS18095 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GH768_RS18110 ENOG4105C85 amino acid GH768_RS18115 ENOG4105SUV lipoprotein YgdR GH768_RS18120 ENOG4108NS2 receptor GH768_RS18125 ENOG4105CHB tonB-dependent Receptor GH768_RS18130 ENOG4108WYP Transcriptional regulator GH768_RS18135 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GH768_RS18140 ENOG4108Z7F N-acetyltransferase GH768_RS18145 ENOG4108T9Y Inner membrane protein ydcZ GH768_RS18150 ENOG4105R71 cytoplasmic protein GH768_RS18170 ENOG410654E Membrane GH768_RS18185 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GH768_RS18190 ENOG4108UQS dipeptidase GH768_RS18205 ENOG4105C4M (Ubiquinol oxidase) subunit I GH768_RS18210 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GH768_RS18220 ENOG4105RR0 Protein of unknown function (DUF2554) GH768_RS18225 ENOG4105CFP Peptidase U32 GH768_RS18230 ENOG4108JCI Transcriptional regulator GH768_RS18235 ENOG4105DKK Benzoate GH768_RS18240 ENOG4108KKZ (LipO)protein GH768_RS18245 ENOG41088CC tellurite resistance protein tehB GH768_RS18250 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein GH768_RS18255 ENOG4107WE3 acetyltransferase YdcK GH768_RS18260 ENOG4108Z9I -acetyltransferase GH768_RS18275 ENOG4105EN6 Membrane GH768_RS18280 ENOG4105CH2 amidohydrolase GH768_RS18290 ENOG4108WN0 inhibitor of vertebrate lysozyme GH768_RS18370 ENOG4108PQ7 sgc region transcriptional regulator GH768_RS18385 ENOG4108YYC ycei family GH768_RS18395 ENOG4105EBR Carboxylesterase GH768_RS18400 ENOG4105E32 cytoplasmic protein GH768_RS18405 ENOG4105DDW LysR family Transcriptional regulator GH768_RS18410 ENOG4105C8Q Methyl-accepting chemotaxis GH768_RS18435 ENOG4107ZUJ lipid metabolic process GH768_RS18445 ENOG4107R0W ABC transporter GH768_RS18450 ENOG4105E5Q amino acid AbC transporter GH768_RS18460 ENOG4105E5Q amino acid AbC transporter GH768_RS18465 ENOG4108WF3 methyltransferase GH768_RS18470 ENOG4105CPW cytochrome b561 GH768_RS18475 ENOG4107DB1 DUF218 domain GH768_RS18480 ENOG4105CQ7 ATP-dependent helicase GH768_RS18485 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GH768_RS18495 ENOG4105WXT Conserved Protein GH768_RS18500 ENOG410689M (LipO)protein GH768_RS18505 ENOG4107H52 Dicarboxylate transport GH768_RS18510 ENOG4105C5I Dehydrogenase GH768_RS18515 ENOG41090X5 Heat shock protein hslJ GH768_RS18520 ENOG4105IKK cytoplasmic protein GH768_RS18530 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GH768_RS18535 ENOG4108RW8 Universal stress protein F GH768_RS18540 ENOG410814C multidrug resistance protein GH768_RS18560 ENOG4105C1J atp-dependent rna helicase GH768_RS18570 ENOG4105C8Q Methyl-accepting chemotaxis GH768_RS18575 ENOG4108DG9 Smr protein MutS2 GH768_RS18580 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GH768_RS18585 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GH768_RS18590 ENOG4105Q9Y Universal stress protein GH768_RS18595 ENOG4105S5I Membrane GH768_RS18600 ENOG4105D64 Mechanosensitive ion channel GH768_RS18620 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GH768_RS18640 ENOG4106PHM regulatory protein GH768_RS18650 ENOG4108XFH Transcriptional regulator GH768_RS18655 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GH768_RS18660 ENOG4108RVA ribokinase GH768_RS18670 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GH768_RS18690 ENOG4105CV8 reductase GH768_RS18725 ENOG4105C2C drug resistance transporter, Bcr CflA GH768_RS18735 ENOG4105EQ2 LysR family Transcriptional regulator GH768_RS18740 ENOG4107SET aldo keto reductase GH768_RS18750 ENOG4107QSI ABC, transporter GH768_RS18755 ENOG4105KXI murein peptide amidase A GH768_RS18760 ENOG4107S8C mandelate racemase muconate lactonizing GH768_RS18765 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GH768_RS18770 ENOG4108JU8 Transcriptional regulator GH768_RS18780 ENOG4105CM6 amino acid regulated cytosolic protein GH768_RS18785 ENOG4105K8Z Phage shock protein GH768_RS18790 ENOG4105NNG Peripheral inner membrane phage-shock protein GH768_RS18795 ENOG4105FM1 phage shock protein C GH768_RS18800 ENOG4105YYT phage shock protein B GH768_RS18805 ENOG41087YS Phage shock protein A GH768_RS18810 ENOG4105E51 psp operon transcriptional activator GH768_RS18815 ENOG4108J59 Extracellular solute-binding protein, family 5 GH768_RS18820 ENOG4108EKA peptide transport system, permease GH768_RS18850 ENOG4105KT5 UmuD protein GH768_RS18875 ENOG4108EU3 peptide transport system, permease GH768_RS18880 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GH768_RS18885 ENOG4108JQ2 peptide transport system atp-binding protein GH768_RS18905 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GH768_RS18920 ENOG4105BZU Histidine kinase GH768_RS18930 ENOG4105N2W Transcriptional regulator GH768_RS18935 ENOG41061RM osmotically inducible lipoprotein GH768_RS18940 ENOG4108ZJT translation initiation factor, Sui1 GH768_RS18950 ENOG4105CFV Tetratricopeptide repeat protein GH768_RS18955 ENOG4105Q4A inner membrane protein yciS GH768_RS18960 ENOG4105EYK Phosphatidylglycerophosphatase B GH768_RS18965 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GH768_RS18970 ENOG4107QM5 aconitate hydratase GH768_RS18985 ENOG4107R11 Transcriptional regulator GH768_RS18990 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GH768_RS18995 ENOG4105RKX Protein of unknown function (DUF2498) GH768_RS19000 ENOG4105ERU peptidase GH768_RS19005 ENOG4105UBK short-chain dehydrogenase reductase GH768_RS19010 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GH768_RS19015 ENOG4105FE9 pseudouridine synthase GH768_RS19020 ENOG4107RTD sua5 ycio yrdc ywlc family protein GH768_RS19025 ENOG4105DB7 PHP domain protein GH768_RS19035 ENOG4105CRQ synthase (Component I) GH768_RS19040 ENOG4108EFP Anthranilate synthase component II GH768_RS19045 ENOG4105DK0 Indole-3-glycerol phosphate synthase GH768_RS19065 ENOG4108Z9Z response to DNA damage stimulus GH768_RS19070 ENOG4108N8X transition metal ion binding GH768_RS19075 ENOG4105WEF catalase GH768_RS19080 ENOG4105EIF outer membrane protein W GH768_RS19085 ENOG4105PI0 Ferredoxin GH768_RS19100 ENOG4105NAU thioesterase Superfamily protein GH768_RS19105 ENOG410822N TonB family GH768_RS19110 ENOG4105K9H YciI-like protein GH768_RS19130 ENOG4105EYW Ion transport protein GH768_RS19135 ENOG4108JQ7 (ABC) transporter GH768_RS19140 ENOG4105C3U ABC transporter GH768_RS19145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH768_RS19150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH768_RS19155 ENOG4107QSI ABC, transporter GH768_RS19160 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GH768_RS19165 ENOG4105C0A alcohol dehydrogenase GH768_RS19180 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GH768_RS19185 ENOG4105I93 response regulator GH768_RS19190 ENOG4105D78 K07001 NTE family protein GH768_RS19200 ENOG4105CIY formyltetrahydrofolate deformylase GH768_RS19230 ENOG41076YT nitrate reductase, gamma subunit GH768_RS19235 ENOG4105R3A Nitrate reductase GH768_RS19240 ENOG4108IUE nitrate reductase beta subunit GH768_RS19245 ENOG4105CRU nitrate reductase, alpha subunit GH768_RS19250 ENOG4105DQQ Major facilitator superfamily MFS_1 GH768_RS19255 ENOG4105BZU Histidine kinase GH768_RS19260 ENOG4105WH1 Two component transcriptional regulator luxr family GH768_RS19265 ENOG4105ID0 Putative invasin GH768_RS19270 ENOG41090EX DsrE family GH768_RS19275 ENOG4108NH8 Cation transport protein GH768_RS19280 ENOG4105WS7 Cation transport regulator GH768_RS19285 ENOG4105EWV Sodium calcium exchanger membrane region GH768_RS19290 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GH768_RS19295 ENOG41063JG Transcriptional regulator GH768_RS19300 ENOG4108YY7 Invasion gene expression up-regulator SirB GH768_RS19305 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GH768_RS19315 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GH768_RS19325 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GH768_RS19330 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GH768_RS19335 ENOG4105CHH sulfate transporter GH768_RS19340 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria GH768_RS19350 ENOG4105C3G gtp-binding protein GH768_RS19355 ENOG4105DFP Integrase GH768_RS19360 ENOG4105MZU cell filamentation protein GH768_RS19380 ENOG4105FA0 parb-like partition protein GH768_RS19405 ENOG4105ENH Sulfatase GH768_RS19410 ENOG4105C4X radical SAM domain protein GH768_RS19420 ENOG4108YTN IIa component GH768_RS19425 ENOG4105F3R pts system mannose fructose sorbose family iid GH768_RS19430 ENOG4105ETZ PTS System GH768_RS19435 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB GH768_RS19440 ENOG4105E98 transcriptional regulator DeoR family GH768_RS19445 ENOG4105CBG Sulfatase GH768_RS19450 ENOG4108QGT oligogalacturonate-specific porin GH768_RS19465 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit GH768_RS19470 ENOG4108USZ hydrogenase GH768_RS19475 ENOG4108VXY Hydrogenase-1 operon protein HyaE GH768_RS19480 ENOG4105MVP hydrogenase-1 operon protein HyaF GH768_RS19485 ENOG4105C4M (Ubiquinol oxidase) subunit I GH768_RS19490 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GH768_RS19500 ENOG4105D82 Glutamate dehydrogenase GH768_RS19515 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) GH768_RS19525 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GH768_RS19535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GH768_RS19545 ENOG4105ED1 spovr family GH768_RS19560 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GH768_RS19570 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation GH768_RS19605 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GH768_RS19620 ENOG4107QMS site-determining protein GH768_RS19630 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GH768_RS19635 ENOG4105CEY Amp-dependent synthetase and ligase GH768_RS19640 ENOG4105Y4Z Outer Membrane Lipoprotein GH768_RS19645 ENOG41072GX Peptidase M22 Glycoprotease GH768_RS19650 ENOG4105DVT helicase GH768_RS19655 ENOG4105M4H endoribonuclease L-psp GH768_RS19660 ENOG4105X5C UPF0181 protein GH768_RS19665 ENOG4105CRQ synthase (Component I) GH768_RS19675 ENOG4105EJQ L-serine dehydratase GH768_RS19680 ENOG4107XTP (EAL) domain protein GH768_RS19685 ENOG4105EE5 Membrane protein terC GH768_RS19690 ENOG4105DAS pts system GH768_RS19695 ENOG4105ETZ PTS System GH768_RS19700 ENOG4105F3R pts system mannose fructose sorbose family iid GH768_RS19715 ENOG4105DHI Methyltransferase GH768_RS19720 ENOG4105CJN penicillin-binding protein GH768_RS19735 ENOG4105Q3Y exported protein GH768_RS19740 ENOG4106CCY Protein MgrB homolog GH768_RS19750 ENOG4105J4Q Transcriptional regulator GH768_RS19755 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH768_RS19760 ENOG4105D0M Protease HtpX homolog GH768_RS19765 ENOG4105CN1 protease GH768_RS19775 ENOG4108ZGC gaf domain protein GH768_RS19780 ENOG4105H2K paraquat-inducible protein a GH768_RS19785 ENOG4105DY2 Paraquat-inducible protein b GH768_RS19795 ENOG4105WT8 Protein of unknown function (DUF1480) GH768_RS19800 ENOG4105UVW uncharacterized protein yebW GH768_RS19805 ENOG4108R1E Serine threonine protein phosphatase 1 GH768_RS19810 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling GH768_RS19825 ENOG4108YXQ IS66 Orf2 family protein GH768_RS19845 ENOG4106P2F Pfam:Pili_assembly_C GH768_RS19895 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GH768_RS19925 ENOG4105UZW Tail fiber assembly protein GH768_RS19950 ENOG41084S7 Plasmid maintenance system antidote protein GH768_RS19965 ENOG4105NKT exported protein GH768_RS19970 ENOG4108PNC copper resistance GH768_RS19975 ENOG4105FXM Copper resistance protein GH768_RS19980 ENOG4105MPK DNA polymerase III subunit theta GH768_RS19985 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GH768_RS19990 ENOG4105UMD exodeoxyribonuclease X GH768_RS19995 ENOG4105CUG Oligopeptidase b GH768_RS20000 ENOG4108Q2J Inner membrane protein YebE GH768_RS20010 ENOG4105X2V dna damage-inducible protein GH768_RS20015 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GH768_RS20020 ENOG4108UHU Aldolase GH768_RS20025 ENOG4105C01 Dihydroxy-acid dehydratase GH768_RS20030 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GH768_RS20035 ENOG4106KNT transcriptional regulator GH768_RS20040 ENOG4105CA9 Pyruvate kinase GH768_RS20045 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GH768_RS20050 ENOG4105DR5 peptidase GH768_RS20055 ENOG4105NXV High-affinity zinc uptake system protein GH768_RS20065 ENOG4105FAV ABC, transporter GH768_RS20075 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GH768_RS20085 ENOG4105CDY transcriptional regulatory protein GH768_RS20090 ENOG4108TIT dATP pyrophosphohydrolase GH768_RS20100 ENOG4105D3W isochorismatase GH768_RS20105 ENOG41081XQ Conserved Protein GH768_RS20110 ENOG4105WJG Glutathione GH768_RS20120 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GH768_RS20130 ENOG4106ZCM YecM protein GH768_RS20145 ENOG4105F5H Glycosyl Hydrolase Family 88 GH768_RS20150 ENOG4105IRD Flagellar protein FlhE GH768_RS20155 ENOG4105D7B Flagellar biosynthesis protein flha GH768_RS20160 ENOG4105D00 flagellar biosynthetic protein flhB GH768_RS20165 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GH768_RS20170 ENOG4108VYJ response regulator receiver protein GH768_RS20180 ENOG4105BZU Histidine kinase GH768_RS20185 ENOG4105C8Q Methyl-accepting chemotaxis GH768_RS20190 ENOG4108V3W Chemotaxis protein, CheW GH768_RS20195 ENOG4105CBS Chea signal transduction histidine kinase GH768_RS20200 ENOG4105ER2 Ompa motb domain protein GH768_RS20205 ENOG4107RD7 Flagellar Motor Protein, MotA GH768_RS20210 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region GH768_RS20215 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) GH768_RS20225 ENOG4108VA4 Universal stress protein GH768_RS20235 ENOG4108K4C ec 3.1.3.12 GH768_RS20250 ENOG4108UEC Ferritin-like protein GH768_RS20255 ENOG4105N4N Protein of unknown function (DUF2766) GH768_RS20265 ENOG4105P23 (LipO)protein GH768_RS20270 ENOG41090A1 ferritin GH768_RS20275 ENOG4105VVZ metal-binding protein GH768_RS20280 ENOG4105E0U tyrosine-specific transport protein GH768_RS20285 ENOG4106RHG Yeca family GH768_RS20335 ENOG4105WH1 Two component transcriptional regulator luxr family GH768_RS20340 ENOG4105XVG cytoplasmic protein GH768_RS20345 ENOG4105VJY transcriptional regulator GH768_RS20350 ENOG4105CDA abc transporter atp-binding protein GH768_RS20355 ENOG4105E5Q amino acid AbC transporter GH768_RS20360 ENOG4105K6H D-cysteine desulfhydrase GH768_RS20365 ENOG4105EAB amino acid AbC transporter GH768_RS20370 ENOG4108M9K flagella biosynthesis protein FliZ GH768_RS20375 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH768_RS20385 ENOG4105I03 Flagellin GH768_RS20390 ENOG4105DTS flagellar hook-associated GH768_RS20395 ENOG4105MQ3 flagellar protein FliS GH768_RS20405 ENOG4105E5K Alpha-amylase GH768_RS20410 ENOG4105JCU Inherit from NOG: (Lipo)protein GH768_RS20415 ENOG41066VF YeeE YedE family protein GH768_RS20430 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GH768_RS20435 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GH768_RS20440 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GH768_RS20445 ENOG41090PJ Flagellar assembly protein GH768_RS20450 ENOG4108JIR Flagellum-specific ATP synthase GH768_RS20455 ENOG4105GSA Flagellar export protein flij GH768_RS20460 ENOG4105WF4 Flagellar hook-length control protein GH768_RS20465 ENOG4107ZI8 flagellar basal body-associated protein flil GH768_RS20470 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GH768_RS20475 ENOG4105DD5 Flagellar motor switch protein GH768_RS20480 ENOG4105K0P flagellar biosynthesis protein GH768_RS20485 ENOG4105CN7 Flagellar biosynthetic protein FliP GH768_RS20490 ENOG4105VS8 Flagellar biosynthetic protein fliq GH768_RS20495 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GH768_RS20500 ENOG4107TKS colanic acid capsular biosynthesis activation protein A GH768_RS20510 ENOG4105YX3 cellular response to acidity GH768_RS20515 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase GH768_RS20520 ENOG4105BZU Histidine kinase GH768_RS20525 ENOG4105VNZ cytoplasmic protein GH768_RS20530 ENOG4105CKW Inner membrane protein yedI GH768_RS20535 ENOG4105FDR Membrane GH768_RS20540 ENOG41090BB DNA mismatch endonuclease (vsr) GH768_RS20545 ENOG4105DVF Cytosine-specific methyltransferase GH768_RS20550 ENOG4105EST Metal Dependent Phosphohydrolase GH768_RS20555 ENOG4105Y0K Inner membrane protein YedR GH768_RS20560 ENOG4105FCK Membrane GH768_RS20655 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GH768_RS20715 ENOG4105HVQ Regulatory factor of maltose metabolism GH768_RS20735 ENOG4105UQX Mate efflux family protein GH768_RS20770 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH768_RS20790 ENOG41090HJ UPF0265 protein GH768_RS20795 ENOG4105DR8 Membrane GH768_RS20800 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) GH768_RS20805 ENOG4105DZ1 carboxypeptidase GH768_RS20810 ENOG4108NWD Cytochrome GH768_RS20815 ENOG4105QAX Iron-sulfur GH768_RS20820 ENOG4108J2R molybdopterin oxidoreductase GH768_RS20825 ENOG4105CJB Exodeoxyribonuclease I GH768_RS20830 ENOG4105CUB amino acid GH768_RS20840 ENOG4105EQ1 Transcriptional regulator GH768_RS20845 ENOG4107SRH Nad-dependent epimerase dehydratase GH768_RS20860 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GH768_RS20870 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GH768_RS20875 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GH768_RS20890 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GH768_RS20895 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) GH768_RS20900 ENOG4105C6Y Udp-glucose 6-dehydrogenase GH768_RS20905 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GH768_RS20910 ENOG4107QKV phosphomannomutase GH768_RS20925 ENOG4105FGF GDP-mannose mannosyl hydrolase GH768_RS20930 ENOG4105C30 Nad-dependent epimerase dehydratase GH768_RS20935 ENOG4105C0K Gdp-mannose 4,6-dehydratase GH768_RS20945 ENOG4105CMR udp-glucose 4-epimerase GH768_RS20960 ENOG4105ECJ Glycosyl Transferase GH768_RS20965 ENOG4105ER6 polysaccharide biosynthesis protein GH768_RS20970 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GH768_RS20975 ENOG4105DMT epimerase dehydratase GH768_RS20980 ENOG4105G1A colanic acid biosynthesis protein GH768_RS20985 ENOG4107T8Q Glycosyl transferase (Group 1 GH768_RS20990 ENOG4105C74 pyruvyl transferase GH768_RS20995 ENOG4105PSV Polysaccharide Biosynthesis Protein GH768_RS21000 ENOG4105D3Q Sugar transferase GH768_RS21005 ENOG4107QKV phosphomannomutase GH768_RS21010 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GH768_RS21015 ENOG4106CD9 glycosyl transferase group 1 GH768_RS21020 ENOG4105FGF GDP-mannose mannosyl hydrolase GH768_RS21025 ENOG4105C30 Nad-dependent epimerase dehydratase GH768_RS21030 ENOG4105C0K Gdp-mannose 4,6-dehydratase GH768_RS21035 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF GH768_RS21040 ENOG4105ECJ Glycosyl Transferase GH768_RS21045 ENOG4108NYJ Colanic acid GH768_RS21050 ENOG4107RXY Glycosyl transferase GH768_RS21055 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB GH768_RS21060 ENOG41090RK glycosyl transferase GH768_RS21065 ENOG4105D75 Capsular exopolysaccharide family GH768_RS21070 ENOG4105KJF protein tyrosine phosphatase GH768_RS21075 ENOG4105DAY polysaccharide export protein GH768_RS21080 ENOG4105EE5 Membrane protein terC GH768_RS21085 ENOG4108GAE asmA family GH768_RS21090 ENOG4105DHP deoxycytidine triphosphate deaminase GH768_RS21100 ENOG4105BZU Histidine kinase GH768_RS21105 ENOG4105D03 DNA-3-methyladenine glycosylase II GH768_RS21110 ENOG4105R8A Heat shock protein GH768_RS21140 ENOG4105EB3 Histidine kinase GH768_RS21145 ENOG4105E3W Two component transcriptional regulator (Winged helix family GH768_RS21150 ENOG4105CFP Peptidase U32 GH768_RS21155 ENOG41090V3 Tir chaperone protein (CesT) family GH768_RS21165 ENOG4105EIE fructose-bisphosphate aldolase GH768_RS21170 ENOG4105EAA nucleoside GH768_RS21175 ENOG4108KD5 ADP-ribosylation crystallin J1 GH768_RS21180 ENOG4108TFM Kinase, PfkB family GH768_RS21185 ENOG4105FDP GntR family transcriptional regulator GH768_RS21190 ENOG4105DWF phosphomethylpyrimidine kinase GH768_RS21200 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly GH768_RS21210 ENOG4105CW0 outer membrane usher protein GH768_RS21215 ENOG4108MQF Chaperone GH768_RS21220 ENOG41063W2 Fimbrial protein GH768_RS21230 ENOG4105D1F ATP-binding protein GH768_RS21235 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GH768_RS21240 ENOG4108YCW (LipO)protein GH768_RS21245 ENOG4108W15 Protein of unknown function (DUF1456) GH768_RS21250 ENOG4108NEV two component transcriptional regulator, LytTR family GH768_RS21255 ENOG4108HRK Histidine kinase GH768_RS21270 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component GH768_RS21275 ENOG4108IJ8 ABC transporter GH768_RS21280 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component GH768_RS21285 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GH768_RS21290 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GH768_RS21295 ENOG4105CXG d-lactate dehydrogenase GH768_RS21300 ENOG41061WM D-Alanyl-D-Alanine GH768_RS21305 ENOG41069YE inner membrane protein yohC GH768_RS21310 ENOG4105KHU inner membrane protein YohD GH768_RS21315 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GH768_RS21320 ENOG4105ETP RND efflux system, outer membrane lipoprotein GH768_RS21330 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GH768_RS21335 ENOG4105MSY salicylate hydroxylase GH768_RS21340 ENOG4108RXX maleylacetoacetate isomerase GH768_RS21365 ENOG4105VAW lrga family GH768_RS21370 ENOG41067MG lrgb family GH768_RS21385 ENOG4107GZ4 SanA protein GH768_RS21390 ENOG4105Y9N Membrane GH768_RS21395 ENOG4105BZ8 glutamate synthase GH768_RS21400 ENOG4107SJI Dehydrogenase GH768_RS21405 ENOG4107SDZ Galactoside transport system permease protein mglC GH768_RS21410 ENOG4105C2J ABC transporter GH768_RS21415 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator GH768_RS21420 ENOG41060NJ transcriptional regulator GH768_RS21425 ENOG4105DHF Membrane GH768_RS21430 ENOG4105EUJ GTP cyclohydrolase i GH768_RS21445 ENOG4105D05 Receptor GH768_RS21450 ENOG4108IQI permease GH768_RS21455 ENOG4105DUM transcriptional regulator, lysR family GH768_RS21460 ENOG4105HMI Membrane GH768_RS21465 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GH768_RS21470 ENOG4105DM4 PTS System GH768_RS21475 ENOG4105DE4 1-phosphofructokinase GH768_RS21480 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GH768_RS21485 ENOG4105S8Q sugar efflux transporter GH768_RS21490 ENOG4105KRS Proteinase inhibitor GH768_RS21495 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GH768_RS21500 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GH768_RS21505 ENOG4108EM1 reductase GH768_RS21510 ENOG4105CUW cytochrome C-TYPE protein GH768_RS21515 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GH768_RS21520 ENOG4105CKI cobalamin synthesis protein GH768_RS21525 ENOG41076MN Phosphoesterase, PA-phosphatase related GH768_RS21530 ENOG4107TT5 NLP P60 protein GH768_RS21535 ENOG4105CXC rtn protein GH768_RS21540 ENOG4105E43 Extracellular solute-binding protein, family 5 GH768_RS21545 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GH768_RS21550 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GH768_RS21555 ENOG4108JQ5 ABC transporter GH768_RS21560 ENOG4105HG6 GH768_RS21565 ENOG4105C2C drug resistance transporter, Bcr CflA GH768_RS21570 ENOG4105I08 Pseudouridine synthase GH768_RS21575 ENOG4105CFI type iii restriction protein res subunit GH768_RS21595 ENOG4105E68 Sulfatase GH768_RS21650 ENOG4105WH1 Two component transcriptional regulator luxr family GH768_RS21680 ENOG4105D8V Glucose sorbosone dehydrogenase GH768_RS21735 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase GH768_RS21755 ENOG4105E3W Two component transcriptional regulator (Winged helix family GH768_RS21780 ENOG4105D8V Glucose sorbosone dehydrogenase