locus-tag	class	description
HWC64_gp002	COG1702	phosphate starvation-inducible protein PhoH
HWC64_gp004	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWC64_gp007	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWC64_gp011	COG0328	RNA-DNA hybrid ribonuclease activity
HWC64_gp023	COG1328	CTP reductase activity
HWC64_gp026	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWC64_gp039	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWC64_gp040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWC64_gp043	COG0358	DNA primase activity
HWC64_gp052	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWC64_gp053	COG0756	dUTP diphosphatase activity
HWC64_gp141	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HWC64_gp164	COG3172	ATPase kinase involved in NAD metabolism