locus-tag	class	description
HOT63_gp023	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HOT63_gp024	ENOG4105C2M	dna polymerase I
HOT63_gp032	ENOG4105C2M	dna polymerase I
HOT63_gp033	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HOT63_gp036	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HOT63_gp037	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HOT63_gp051	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HOT63_gp055	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HOT63_gp058	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HOT63_gp059	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HOT63_gp061	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HOT63_gp063	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HOT63_gp108	ENOG4105MEW	serine threonine protein phosphatase
HOT63_gp128	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)