locus-tag	class	description
I6H42_RS00015	COG0515	serine threonine protein kinase
I6H42_RS00020	COG1404	Belongs to the peptidase S8 family
I6H42_RS00025	COG1404	Belongs to the peptidase S8 family
I6H42_RS00045	COG1674	ftsk spoiiie
I6H42_RS00085	COG1404	Belongs to the peptidase S8 family
I6H42_RS00110	COG0569	domain protein
I6H42_RS00115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H42_RS00130	COG0406	alpha-ribazole phosphatase activity
I6H42_RS00140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H42_RS00185	COG0366	Alpha amylase catalytic
I6H42_RS00190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6H42_RS00195	COG4948	Mandelate Racemase Muconate Lactonizing
I6H42_RS00200	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6H42_RS00205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H42_RS00210	COG1169	isochorismate synthase
I6H42_RS00215	COG2226	methyltransferase
I6H42_RS00220	COG1404	Belongs to the peptidase S8 family
I6H42_RS00245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H42_RS00250	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H42_RS00255	COG0649	NAD binding
I6H42_RS00265	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6H42_RS00270	COG1034	ATP synthesis coupled electron transport
I6H42_RS00280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H42_RS00290	COG0713	ATP synthesis coupled electron transport
I6H42_RS00295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H42_RS00305	COG1007	ATP synthesis coupled electron transport
I6H42_RS00310	COG0142	geranyltranstransferase activity
I6H42_RS00320	COG0501	Belongs to the peptidase M48B family
I6H42_RS00325	COG1666	GTP binding
I6H42_RS00345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H42_RS00355	COG2188	Transcriptional regulator
I6H42_RS00360	COG0747	negative chemotaxis
I6H42_RS00365	COG0601	transmembrane transport
I6H42_RS00375	COG4608	Belongs to the ABC transporter superfamily
I6H42_RS00380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H42_RS00390	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6H42_RS00395	COG0738	Major facilitator superfamily
I6H42_RS00400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H42_RS00405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H42_RS00415	COG0436	Aminotransferase
I6H42_RS00425	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H42_RS00435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H42_RS00440	COG0081	regulation of translation
I6H42_RS00455	COG1129	ABC transporter
I6H42_RS00460	COG2375	cellular response to nickel ion
I6H42_RS00460	COG1132	(ABC) transporter
I6H42_RS00465	COG1132	(ABC) transporter
I6H42_RS00475	COG0222	ribosome binding
I6H42_RS00480	COG0789	Transcriptional regulator
I6H42_RS00495	COG1129	ABC transporter
I6H42_RS00500	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H42_RS00510	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
I6H42_RS00520	COG1609	Transcriptional regulator
I6H42_RS00530	COG1349	DNA-binding transcription factor activity
I6H42_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
I6H42_RS00560	COG1063	alcohol dehydrogenase
I6H42_RS00565	COG1115	amino acid carrier protein
I6H42_RS00585	COG0431	NADPH-dependent FMN reductase
I6H42_RS00620	COG1335	isochorismatase
I6H42_RS00625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H42_RS00635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H42_RS00635	COG2190	(PTS) system
I6H42_RS00635	COG1263	PTS System
I6H42_RS00640	COG1609	Transcriptional regulator
I6H42_RS00650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H42_RS00670	COG2197	response regulator
I6H42_RS00675	COG4868	Belongs to the UPF0371 family
I6H42_RS00685	COG0045	succinate-CoA ligase (ADP-forming) activity
I6H42_RS00700	COG1268	BioY protein
I6H42_RS00705	COG0519	Catalyzes the synthesis of GMP from XMP
I6H42_RS00705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H42_RS00730	COG2323	membrane
I6H42_RS00770	COG1131	(ABC) transporter
I6H42_RS00775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H42_RS00785	COG1573	uracil-dna glycosylase
I6H42_RS00790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6H42_RS00795	COG2264	protein methyltransferase activity
I6H42_RS00810	COG3949	Membrane
I6H42_RS00815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H42_RS00825	COG1136	(ABC) transporter
I6H42_RS00825	COG0577	efflux transmembrane transporter activity
I6H42_RS00835	COG0084	hydrolase, TatD family'
I6H42_RS00840	COG3583	domain protein
I6H42_RS00850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H42_RS00855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H42_RS00860	COG0488	(ABC) transporter
I6H42_RS00920	COG1309	transcriptional regulator
I6H42_RS00930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H42_RS00940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H42_RS00945	COG0662	Cupin 2, conserved barrel domain protein
I6H42_RS00945	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6H42_RS00960	COG1611	Belongs to the LOG family
I6H42_RS00985	COG2239	Acts as a magnesium transporter
I6H42_RS00995	COG0006	proline dipeptidase activity
I6H42_RS01000	COG0252	asparaginase activity
I6H42_RS01005	COG1113	amino acid transport
I6H42_RS01010	COG0613	PHP domain protein
I6H42_RS01015	COG2095	MarC family integral membrane protein
I6H42_RS01025	COG0058	SHG alpha-glucan phosphorylase activity
I6H42_RS01035	COG1131	(ABC) transporter
I6H42_RS01090	COG0395	ABC-type sugar transport system, permease component
I6H42_RS01105	COG3475	LICD family
I6H42_RS01110	COG0438	transferase activity, transferring glycosyl groups
I6H42_RS01120	COG3475	LICD family
I6H42_RS01125	COG3475	LICD family
I6H42_RS01130	COG3475	LICD family
I6H42_RS01135	COG0697	spore germination
I6H42_RS01190	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H42_RS01240	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I6H42_RS01245	COG0714	Associated with various cellular activities
I6H42_RS01265	COG0745	RESPONSE REGULATOR receiver
I6H42_RS01270	COG5002	protein histidine kinase activity
I6H42_RS01270	COG5000	phosphorelay sensor kinase activity
I6H42_RS01285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H42_RS01290	COG0653	protein targeting
I6H42_RS01330	COG0419	ATPase involved in DNA repair
I6H42_RS01335	COG0420	3'-5' exonuclease activity
I6H42_RS01360	COG1162	GTPase activity
I6H42_RS01365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H42_RS01395	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H42_RS01395	COG0567	Dehydrogenase, E1 component
I6H42_RS01400	COG1253	flavin adenine dinucleotide binding
I6H42_RS01410	COG0739	heme binding
I6H42_RS01415	COG0584	glycerophosphoryl diester phosphodiesterase
I6H42_RS01435	COG2826	transposase and inactivated derivatives, IS30 family
I6H42_RS01440	COG2826	transposase and inactivated derivatives, IS30 family
I6H42_RS01445	COG2826	transposase and inactivated derivatives, IS30 family
I6H42_RS01490	COG0018	arginyl-trna synthetase
I6H42_RS01535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H42_RS01545	COG1643	Atp-dependent helicase
I6H42_RS01555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H42_RS01565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H42_RS01570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H42_RS01575	COG1556	Lactate utilization protein
I6H42_RS01580	COG1139	Iron-sulfur cluster binding protein
I6H42_RS01620	COG1620	l-lactate permease
I6H42_RS01625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H42_RS01640	COG1381	Involved in DNA repair and RecF pathway recombination
I6H42_RS01645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H42_RS01665	COG1121	(ABC) transporter
I6H42_RS01680	COG2182	Extracellular solute-binding protein
I6H42_RS01685	COG1175	transmembrane transport
I6H42_RS01690	COG3833	ABC-type maltose transport systems, permease component
I6H42_RS01700	COG1131	(ABC) transporter
I6H42_RS01710	COG0423	glycine-tRNA ligase activity
I6H42_RS01715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H42_RS01720	COG0710	3-dehydroquinate dehydratase activity
I6H42_RS01735	COG0358	DNA primase activity
I6H42_RS01755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H42_RS01760	COG1132	(ABC) transporter
I6H42_RS01765	COG1132	(ABC) transporter
I6H42_RS01775	COG0519	Catalyzes the synthesis of GMP from XMP
I6H42_RS01775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H42_RS01780	COG0129	dihydroxy-acid dehydratase activity
I6H42_RS01785	COG0095	Lipoate-protein ligase
I6H42_RS01795	COG3304	Inner membrane component domain
I6H42_RS01800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H42_RS01815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6H42_RS01825	COG1115	amino acid carrier protein
I6H42_RS01850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H42_RS01880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H42_RS01895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H42_RS01900	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H42_RS01915	COG1129	ABC transporter
I6H42_RS01930	COG1132	(ABC) transporter
I6H42_RS01935	COG2375	cellular response to nickel ion
I6H42_RS01935	COG1132	(ABC) transporter
I6H42_RS01940	COG1309	transcriptional regulator
I6H42_RS01970	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H42_RS01975	COG0740	serine-type endopeptidase activity
I6H42_RS01980	COG0740	serine-type endopeptidase activity
I6H42_RS01985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H42_RS01990	COG0287	Prephenate dehydrogenase
I6H42_RS01990	COG1605	Chorismate mutase
I6H42_RS02005	COG1136	(ABC) transporter
I6H42_RS02005	COG0577	efflux transmembrane transporter activity
I6H42_RS02010	COG0577	efflux transmembrane transporter activity
I6H42_RS02020	COG1609	Transcriptional regulator
I6H42_RS02025	COG3250	beta-galactosidase activity
I6H42_RS02045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H42_RS02050	COG0549	Belongs to the carbamate kinase family
I6H42_RS02055	COG1288	antiporter activity
I6H42_RS02060	COG2197	response regulator
I6H42_RS02065	COG2056	Na+-H+ antiporter family
I6H42_RS02070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H42_RS02075	COG0433	COG0433 Predicted ATPase
I6H42_RS02095	COG1132	(ABC) transporter
I6H42_RS02100	COG1132	(ABC) transporter
I6H42_RS02105	COG0268	Binds directly to 16S ribosomal RNA
I6H42_RS02120	COG0481	GTPase activity
I6H42_RS02125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H42_RS02150	COG1420	regulation of RNA biosynthetic process
I6H42_RS02155	COG0484	heat shock protein binding
I6H42_RS02165	COG2017	converts alpha-aldose to the beta-anomer
I6H42_RS02175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H42_RS02180	COG0242	peptide deformylase activity
I6H42_RS02195	COG1882	Formate acetyltransferase
I6H42_RS02200	COG0460	homoserine dehydrogenase
I6H42_RS02205	COG0083	homoserine kinase activity
I6H42_RS02215	COG0254	rRNA binding
I6H42_RS02220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H42_RS02230	COG0009	L-threonylcarbamoyladenylate synthase
I6H42_RS02235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H42_RS02245	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H42_RS02255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H42_RS02260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H42_RS02265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H42_RS02270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H42_RS02275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H42_RS02290	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6H42_RS02300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6H42_RS02325	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H42_RS02330	COG0366	Alpha amylase catalytic
I6H42_RS02340	COG0180	Tryptophanyl-tRNA synthetase
I6H42_RS02350	COG2086	electron transfer activity
I6H42_RS02355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6H42_RS02365	COG0482	sulfurtransferase activity
I6H42_RS02400	COG1321	iron dependent repressor
I6H42_RS02410	COG0495	leucyl-tRNA aminoacylation
I6H42_RS02425	COG1045	serine acetyltransferase
I6H42_RS02430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H42_RS02435	COG1739	Uncharacterized protein family UPF0029
I6H42_RS02460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6H42_RS02470	COG0736	holo-[acyl-carrier-protein] synthase activity
I6H42_RS02475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H42_RS02475	COG3321	synthase
I6H42_RS02475	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6H42_RS02480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H42_RS02485	COG4770	biotin carboxylase activity
I6H42_RS02515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H42_RS02515	COG1263	PTS System
I6H42_RS02530	COG1216	Glycosyl transferase, family 2
I6H42_RS02540	COG0733	neurotransmitter:sodium symporter activity
I6H42_RS02575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H42_RS02590	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H42_RS02615	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6H42_RS02620	COG2815	serine threonine protein kinase
I6H42_RS02620	COG0515	serine threonine protein kinase
I6H42_RS02630	COG0142	geranyltranstransferase activity
I6H42_RS02635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H42_RS02660	COG0228	four-way junction DNA binding
I6H42_RS02665	COG1837	Belongs to the UPF0109 family
I6H42_RS02670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H42_RS02680	COG0335	large ribosomal subunit rRNA binding
I6H42_RS02685	COG0681	Belongs to the peptidase S26 family
I6H42_RS02690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H42_RS02700	COG0792	nuclease activity
I6H42_RS02725	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H42_RS02730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H42_RS02740	COG0233	cytoplasmic translational termination
I6H42_RS02750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H42_RS02765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6H42_RS02770	COG0750	zinc metalloprotease
I6H42_RS02775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6H42_RS02790	COG0442	prolyl-tRNA aminoacylation
I6H42_RS02810	COG1027	Aspartate ammonia-lyase
I6H42_RS02815	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6H42_RS02830	COG1252	NADH dehydrogenase
I6H42_RS02835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H42_RS02840	COG0321	lipoyl(octanoyl) transferase activity
I6H42_RS02845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H42_RS02865	COG1940	carbohydrate kinase activity
I6H42_RS02875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6H42_RS02895	COG1438	arginine binding
I6H42_RS02900	COG0137	argininosuccinate synthase activity
I6H42_RS02910	COG0165	Argininosuccinate lyase
I6H42_RS02915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H42_RS02940	COG0647	UMP catabolic process
I6H42_RS02955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H42_RS02985	COG0719	Fe-S assembly protein
I6H42_RS02995	COG0396	ATPase activity
I6H42_RS03010	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H42_RS03015	COG0318	PFAM AMP-dependent synthetase and ligase
I6H42_RS03025	COG0343	queuine tRNA-ribosyltransferase activity
I6H42_RS03035	COG0488	(ABC) transporter
I6H42_RS03040	COG1126	abc transporter atp-binding protein
I6H42_RS03045	COG0765	amino acid transport
I6H42_RS03065	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H42_RS03070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H42_RS03080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H42_RS03085	COG1881	PFAM PEBP family protein
I6H42_RS03100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H42_RS03150	COG0656	L-ascorbic acid biosynthetic process
I6H42_RS03165	COG1222	aaa ATPase
I6H42_RS03170	COG4122	O-methyltransferase activity
I6H42_RS03180	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6H42_RS03190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H42_RS03195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H42_RS03200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H42_RS03205	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H42_RS03210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H42_RS03215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H42_RS03225	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6H42_RS03235	COG0194	GDP metabolic process
I6H42_RS03240	COG1758	RNA polymerase activity
I6H42_RS03250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H42_RS03265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H42_RS03275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H42_RS03280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H42_RS03285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H42_RS03310	COG1216	Glycosyl transferase, family 2
I6H42_RS03325	COG0443	Heat shock 70 kDa protein
I6H42_RS03340	COG1716	ATPase activity
I6H42_RS03365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H42_RS03370	COG1160	GTP binding
I6H42_RS03375	COG0519	Catalyzes the synthesis of GMP from XMP
I6H42_RS03395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H42_RS03410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H42_RS03445	COG0363	glucosamine-6-phosphate deaminase activity
I6H42_RS03455	COG0149	triose-phosphate isomerase activity
I6H42_RS03460	COG0126	phosphoglycerate kinase activity
I6H42_RS03465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H42_RS03470	COG1481	regulation of sporulation
I6H42_RS03480	COG1660	Displays ATPase and GTPase activities
I6H42_RS03490	COG0322	excinuclease ABC activity
I6H42_RS03505	COG1022	Amp-dependent synthetase and ligase
I6H42_RS03515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H42_RS03525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H42_RS03540	COG0556	nucleotide-excision repair
I6H42_RS03545	COG0237	dephospho-CoA kinase activity
I6H42_RS03550	COG1114	Component of the transport system for branched-chain amino acids
I6H42_RS03555	COG0539	negative regulation of cytoplasmic translation
I6H42_RS03565	COG2050	protein possibly involved in aromatic compounds catabolism
I6H42_RS03590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H42_RS03615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H42_RS03620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H42_RS03625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H42_RS03645	COG0009	L-threonylcarbamoyladenylate synthase
I6H42_RS03655	COG0477	Major facilitator Superfamily
I6H42_RS03670	COG1162	GTPase activity
I6H42_RS03675	COG0124	histidyl-tRNA synthetase
I6H42_RS03680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H42_RS03685	COG1196	nuclear chromosome segregation
I6H42_RS03690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H42_RS03695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H42_RS03700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H42_RS03705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H42_RS03715	COG2255	four-way junction helicase activity
I6H42_RS03720	COG0632	four-way junction helicase activity
I6H42_RS03725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H42_RS03735	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6H42_RS03740	COG0217	transcriptional regulatory protein
I6H42_RS03760	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6H42_RS03780	COG1119	ATPase activity
I6H42_RS03785	COG0297	glycogen (starch) synthase activity
I6H42_RS03795	COG0560	Phosphoserine phosphatase
I6H42_RS03800	COG1051	belongs to the nudix hydrolase family
I6H42_RS03820	COG0438	transferase activity, transferring glycosyl groups
I6H42_RS03830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H42_RS03840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H42_RS03915	COG0038	chloride channel
I6H42_RS03920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H42_RS03925	COG0531	amino acid
I6H42_RS03930	COG0569	domain protein
I6H42_RS03975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H42_RS03985	COG2814	Major facilitator Superfamily
I6H42_RS04000	COG0187	DNA topoisomerase II activity
I6H42_RS04025	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6H42_RS04030	COG1461	Dihydroxyacetone kinase
I6H42_RS04035	COG2376	Dihydroxyacetone kinase
I6H42_RS04040	COG0285	dihydrofolate synthase activity
I6H42_RS04050	COG0701	Predicted permease
I6H42_RS04060	COG3119	arylsulfatase activity
I6H42_RS04065	COG0641	radical SAM
I6H42_RS04070	COG0730	response to heat
I6H42_RS04075	COG0247	lactate metabolic process
I6H42_RS04080	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6H42_RS04085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6H42_RS04090	COG3590	peptidase
I6H42_RS04125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H42_RS04130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H42_RS04135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H42_RS04140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H42_RS04145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H42_RS04150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H42_RS04155	COG1530	ribonuclease E activity
I6H42_RS04160	COG1271	oxidase subunit
I6H42_RS04165	COG1294	oxidase, subunit
I6H42_RS04170	COG4988	ABC transporter
I6H42_RS04175	COG1132	(ABC) transporter
I6H42_RS04195	COG0571	ribonuclease III activity
I6H42_RS04215	COG0742	ribosomal rna small subunit methyltransferase
I6H42_RS04230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H42_RS04235	COG1309	transcriptional regulator
I6H42_RS04250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H42_RS04255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H42_RS04260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H42_RS04300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H42_RS04305	COG3599	regulation of cell shape
I6H42_RS04315	COG1799	cell septum assembly
I6H42_RS04325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H42_RS04335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H42_RS04340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H42_RS04350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H42_RS04355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H42_RS04360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H42_RS04365	COG0768	penicillin binding
I6H42_RS04375	COG0275	rRNA processing
I6H42_RS04380	COG2001	Belongs to the MraZ family
I6H42_RS04390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H42_RS04410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H42_RS04415	COG0318	PFAM AMP-dependent synthetase and ligase
I6H42_RS04420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H42_RS04430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6H42_RS04445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H42_RS04450	COG2813	Specifically methylates the guanine in position
I6H42_RS04455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H42_RS04460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H42_RS04475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H42_RS04480	COG1546	Belongs to the CinA family
I6H42_RS04480	COG1058	Belongs to the CinA family
I6H42_RS04485	COG2137	regulation of response to DNA damage stimulus
I6H42_RS04490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H42_RS04510	COG1674	ftsk spoiiie
I6H42_RS04520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6H42_RS04535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H42_RS04540	COG0612	Peptidase, M16
I6H42_RS04545	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H42_RS04550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H42_RS04555	COG0196	riboflavin kinase activity
I6H42_RS04560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H42_RS04565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H42_RS04570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H42_RS04580	COG0195	Participates in both transcription termination and antitermination
I6H42_RS04585	COG0779	Required for maturation of 30S ribosomal subunits
I6H42_RS04600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H42_RS04615	COG2985	domain, Protein
I6H42_RS04615	COG0569	domain protein
I6H42_RS04650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H42_RS04655	COG0154	amidase activity
I6H42_RS04660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H42_RS04665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H42_RS04670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H42_RS04700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H42_RS04715	COG0114	fumarate hydratase activity
I6H42_RS04740	COG1136	(ABC) transporter
I6H42_RS04740	COG0577	efflux transmembrane transporter activity
I6H42_RS04750	COG1309	transcriptional regulator
I6H42_RS04775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H42_RS04775	COG3253	May function as heme-dependent peroxidase
I6H42_RS04785	COG0833	amino acid
I6H42_RS04790	COG1285	pathogenesis
I6H42_RS04805	COG1615	UPF0182 protein
I6H42_RS04815	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H42_RS04840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6H42_RS04845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H42_RS04855	COG0583	DNA-binding transcription factor activity
I6H42_RS04865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H42_RS04895	COG0363	glucosamine-6-phosphate deaminase activity
I6H42_RS04900	COG3142	Participates in the control of copper homeostasis
I6H42_RS04905	COG1940	carbohydrate kinase activity
I6H42_RS04915	COG1940	carbohydrate kinase activity
I6H42_RS04920	COG4166	transmembrane transport
I6H42_RS04930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H42_RS04965	COG1937	Protein conserved in bacteria
I6H42_RS04970	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H42_RS04985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H42_RS05000	COG2884	Cell division ATP-binding protein ftsE
I6H42_RS05005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6H42_RS05010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H42_RS05060	COG0463	Glycosyl transferase, family 2
I6H42_RS05075	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H42_RS05100	COG0438	transferase activity, transferring glycosyl groups
I6H42_RS05130	COG1316	TRANSCRIPTIONal
I6H42_RS05135	COG1316	TRANSCRIPTIONal
I6H42_RS05140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H42_RS05145	COG2205	protein histidine kinase activity
I6H42_RS05150	COG0745	RESPONSE REGULATOR receiver
I6H42_RS05160	COG0424	maF-like protein
I6H42_RS05185	COG1217	gtp-binding protein TYPA
I6H42_RS05210	COG0789	Transcriptional regulator
I6H42_RS05235	COG0395	ABC-type sugar transport system, permease component
I6H42_RS05240	COG1175	transmembrane transport
I6H42_RS05245	COG1653	transport
I6H42_RS05270	COG4268	DNA restriction-modification system
I6H42_RS05275	COG1401	restriction endodeoxyribonuclease activity
I6H42_RS05295	COG0012	GTP binding
I6H42_RS05300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6H42_RS05305	COG1570	exodeoxyribonuclease VII activity
I6H42_RS05310	COG1722	exodeoxyribonuclease VII activity
I6H42_RS05320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H42_RS05330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H42_RS05340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H42_RS05345	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H42_RS05375	COG0148	phosphopyruvate hydratase activity
I6H42_RS05390	COG0193	aminoacyl-tRNA hydrolase activity
I6H42_RS05400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H42_RS05415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H42_RS05420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H42_RS05425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H42_RS05475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6H42_RS05475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H42_RS05490	COG0039	L-malate dehydrogenase activity
I6H42_RS05505	COG0644	oxidoreductase
I6H42_RS05510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6H42_RS05515	COG2086	electron transfer activity
I6H42_RS05525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H42_RS05530	COG2271	Major facilitator Superfamily
I6H42_RS05535	COG2030	dehydratase
I6H42_RS05550	COG1960	acyl-CoA dehydrogenase activity
I6H42_RS05575	COG1131	(ABC) transporter
I6H42_RS05610	COG0166	Belongs to the GPI family
I6H42_RS05615	COG0205	6-phosphofructokinase activity
I6H42_RS05625	COG0280	phosphate acetyltransferase
I6H42_RS05625	COG0857	belongs to the CobB CobQ family
I6H42_RS05630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H42_RS05640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H42_RS05655	COG1051	belongs to the nudix hydrolase family
I6H42_RS05655	COG1056	cytidyltransferase-related domain
I6H42_RS05695	COG2226	methyltransferase
I6H42_RS05700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H42_RS05710	COG0813	purine-nucleoside phosphorylase activity
I6H42_RS05715	COG2390	Transcriptional regulator
I6H42_RS05730	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H42_RS05735	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H42_RS05740	COG3845	ABC transporter
I6H42_RS05760	COG0516	GMP reductase activity
I6H42_RS05775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H42_RS05800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6H42_RS05800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H42_RS05810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H42_RS05820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6H42_RS05825	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6H42_RS05835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H42_RS05840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H42_RS05845	COG1053	succinate dehydrogenase
I6H42_RS05855	COG0456	acetyltransferase
I6H42_RS05865	COG0802	atpase or kinase
I6H42_RS05870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H42_RS05875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H42_RS05875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H42_RS05880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H42_RS05885	COG1072	(Pantothenic acid kinase))
I6H42_RS05895	COG0395	ABC-type sugar transport system, permease component
I6H42_RS05930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H42_RS05935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H42_RS05940	COG0101	tRNA pseudouridine synthase activity
I6H42_RS05950	COG0366	Alpha amylase catalytic
I6H42_RS05955	COG0203	ribosomal protein L17
I6H42_RS05960	COG0202	RNA polymerase activity
I6H42_RS05965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H42_RS05970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H42_RS05975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H42_RS05980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H42_RS05985	COG0024	Methionine aminopeptidase
I6H42_RS05990	COG0563	adenylate kinase activity
I6H42_RS06000	COG0200	Binds to the 23S rRNA
I6H42_RS06005	COG1841	ribosomal large subunit assembly
I6H42_RS06010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H42_RS06020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H42_RS06025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H42_RS06030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H42_RS06035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H42_RS06040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H42_RS06045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H42_RS06050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H42_RS06055	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H42_RS06060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H42_RS06065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H42_RS06070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H42_RS06075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H42_RS06080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H42_RS06085	COG0089	rRNA binding
I6H42_RS06090	COG0088	Forms part of the polypeptide exit tunnel
I6H42_RS06095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H42_RS06100	COG0051	transcription antitermination factor activity, RNA binding
I6H42_RS06105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H42_RS06115	COG0049	tRNA binding
I6H42_RS06120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H42_RS06125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H42_RS06130	COG0085	RNA polymerase activity
I6H42_RS06175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H42_RS06180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H42_RS06185	COG1970	mechanosensitive ion channel activity
I6H42_RS06220	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6H42_RS06230	COG2252	PERMEase
I6H42_RS06240	COG1278	Cold shock
I6H42_RS06250	COG1842	Phage shock protein A
I6H42_RS06260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H42_RS06265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H42_RS06275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H42_RS06280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6H42_RS06285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H42_RS06305	COG0745	RESPONSE REGULATOR receiver
I6H42_RS06310	COG2205	protein histidine kinase activity
I6H42_RS06325	COG0459	protein refolding
I6H42_RS06335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H42_RS06350	COG0515	serine threonine protein kinase
I6H42_RS06350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H42_RS06355	COG3842	ATPase activity
I6H42_RS06385	COG0191	fructose-bisphosphate aldolase activity
I6H42_RS06390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H42_RS06400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H42_RS06405	COG0300	oxidoreductase activity
I6H42_RS06455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H42_RS06460	COG0789	Transcriptional regulator
I6H42_RS06465	COG0484	heat shock protein binding
I6H42_RS06475	COG0443	Heat shock 70 kDa protein
I6H42_RS06485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H42_RS06495	COG0346	lactoylglutathione lyase activity
I6H42_RS06510	COG1362	aminopeptidase activity
I6H42_RS06520	COG2985	domain, Protein
I6H42_RS06520	COG0569	domain protein
I6H42_RS06565	COG1136	(ABC) transporter
I6H42_RS06650	COG0714	Associated with various cellular activities
I6H42_RS06660	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6H42_RS06670	COG0306	phosphate transporter
I6H42_RS06685	COG0406	alpha-ribazole phosphatase activity
I6H42_RS06685	COG0494	nUDIX hydrolase
I6H42_RS06700	COG1397	ADP-ribosylglycohydrolase
I6H42_RS06710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H42_RS06780	COG0247	lactate metabolic process
I6H42_RS06780	COG2181	nitrate reductase activity
I6H42_RS06790	COG0717	Belongs to the dCTP deaminase family
I6H42_RS06810	COG0577	efflux transmembrane transporter activity
I6H42_RS06815	COG1136	(ABC) transporter
I6H42_RS06815	COG0577	efflux transmembrane transporter activity
I6H42_RS06830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H42_RS06860	COG2205	protein histidine kinase activity
I6H42_RS06865	COG0745	RESPONSE REGULATOR receiver
I6H42_RS06870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H42_RS06880	COG1136	(ABC) transporter
I6H42_RS06990	COG1205	dead DEAH box helicase
I6H42_RS06990	COG1111	helicase
I6H42_RS07045	COG0596	Alpha beta hydrolase
I6H42_RS07050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H42_RS07070	COG1408	metallophosphoesterase
I6H42_RS07105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H42_RS07140	COG1937	Protein conserved in bacteria
I6H42_RS07145	COG2217	Heavy metal translocating P-type atpase
I6H42_RS07160	COG1215	transferase activity, transferring glycosyl groups
I6H42_RS07170	COG1069	ribulokinase activity
I6H42_RS07185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H42_RS07200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H42_RS07205	COG1597	lipid kinase activity
I6H42_RS07210	COG0077	Prephenate dehydratase
I6H42_RS07320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H42_RS07340	COG4172	Belongs to the ABC transporter superfamily
I6H42_RS07350	COG1113	amino acid transport
I6H42_RS07385	COG2814	Major facilitator Superfamily
I6H42_RS07420	COG0702	epimerase
I6H42_RS07430	COG2115	Belongs to the xylose isomerase family
I6H42_RS07435	COG1070	Carbohydrate kinase
I6H42_RS07440	COG4214	carbohydrate transport
I6H42_RS07445	COG1129	ABC transporter
I6H42_RS07460	COG2964	Protein conserved in bacteria
I6H42_RS07465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6H42_RS07470	COG1757	Na H antiporter
I6H42_RS07475	COG1063	alcohol dehydrogenase
I6H42_RS07480	COG0477	Major facilitator Superfamily
I6H42_RS07485	COG1312	Catalyzes the dehydration of D-mannonate
I6H42_RS07490	COG0246	Mannitol dehydrogenase
I6H42_RS07500	COG0800	Aldolase
I6H42_RS07505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H42_RS07510	COG0698	ribose 5-phosphate isomerase
I6H42_RS07515	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H42_RS07520	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H42_RS07525	COG1129	ABC transporter
I6H42_RS07535	COG1461	Dihydroxyacetone kinase
I6H42_RS07540	COG2376	Dihydroxyacetone kinase
I6H42_RS07550	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H42_RS07555	COG1129	ABC transporter
I6H42_RS07570	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6H42_RS07580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6H42_RS07615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H42_RS07620	COG1121	(ABC) transporter
I6H42_RS07645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H42_RS07650	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H42_RS07665	COG1192	Involved in chromosome partitioning
I6H42_RS07670	COG0357	Ribosomal RNA small subunit methyltransferase G
I6H42_RS07685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H42_RS07690	COG0594	ribonuclease P activity
I6H42_RS07695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H42_RS07700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H42_RS07705	COG0592	DNA-directed DNA polymerase activity
I6H42_RS07710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H42_RS07725	COG0187	DNA topoisomerase II activity
I6H42_RS07730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H42_RS07755	COG0671	phosphoesterase, PA-phosphatase related
I6H42_RS07760	COG3012	SEC-C Motif Domain Protein
I6H42_RS07765	COG0492	ferredoxin-NADP+ reductase activity
I6H42_RS07785	COG0617	tRNA 3'-terminal CCA addition
I6H42_RS07790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6H42_RS07795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H42_RS07800	COG0359	binds to the 23S rRNA
I6H42_RS07805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H42_RS07815	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H42_RS07820	COG0534	Mate efflux family protein
I6H42_RS07825	COG0305	Participates in initiation and elongation during chromosome replication
I6H42_RS07835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6H42_RS07840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6H42_RS07845	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6H42_RS07850	COG0181	hydroxymethylbilane synthase activity
I6H42_RS07860	COG0113	porphobilinogen synthase activity
I6H42_RS07865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H42_RS07895	COG1120	ATPase activity
I6H42_RS07900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H42_RS07910	COG2814	Major facilitator Superfamily
I6H42_RS07915	COG0577	efflux transmembrane transporter activity
I6H42_RS07915	COG1136	(ABC) transporter
I6H42_RS07925	COG4585	Histidine kinase
I6H42_RS07955	COG0471	metal ion transport
I6H42_RS07960	COG4191	Histidine kinase
I6H42_RS07965	COG2204	response regulator
I6H42_RS07985	COG0778	Nitroreductase
I6H42_RS07990	COG0596	Alpha beta hydrolase
I6H42_RS08020	COG1136	(ABC) transporter
I6H42_RS08050	COG1404	Belongs to the peptidase S8 family
I6H42_RS08075	COG0705	Rhomboid family
I6H42_RS08075	COG0457	Tetratricopeptide repeat
I6H42_RS08095	COG3764	Sortase (surface protein transpeptidase)
I6H42_RS08105	COG0515	serine threonine protein kinase
I6H42_RS08110	COG0515	serine threonine protein kinase
I6H42_RS08115	COG0768	penicillin binding
I6H42_RS08130	COG1716	ATPase activity
I6H42_RS08135	COG1716	ATPase activity
I6H42_RS08140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H42_RS08160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H42_RS08190	COG5002	protein histidine kinase activity
I6H42_RS08195	COG0745	RESPONSE REGULATOR receiver
I6H42_RS08200	COG0328	RNA-DNA hybrid ribonuclease activity
I6H42_RS08225	COG1780	Probably involved in ribonucleotide reductase function
I6H42_RS08230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H42_RS08255	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H42_RS08255	COG1136	(ABC) transporter
I6H42_RS08260	COG0577	efflux transmembrane transporter activity
I6H42_RS08265	COG1760	l-serine dehydratase
I6H42_RS08270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H42_RS08275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H42_RS08285	COG0572	uridine kinase
I6H42_RS08290	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6H42_RS08300	COG1643	Atp-dependent helicase
I6H42_RS08330	COG2860	membrane
I6H42_RS08335	COG1113	amino acid transport
I6H42_RS08350	COG2197	response regulator
I6H42_RS08355	COG4585	Histidine kinase
I6H42_RS08365	COG1131	(ABC) transporter
I6H42_RS08375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H42_RS08380	COG0601	transmembrane transport
I6H42_RS08385	COG4166	transmembrane transport
I6H42_RS08415	COG2233	PERMEase
I6H42_RS08445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H42_RS08450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H42_RS08455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H42_RS08460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H42_RS08465	COG2011	ABC-type metal ion transport system permease component
I6H42_RS08475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H42_RS08480	COG0590	tRNA wobble adenosine to inosine editing
I6H42_RS08505	COG1404	Belongs to the peptidase S8 family
I6H42_RS08510	COG1404	Belongs to the peptidase S8 family
I6H42_RS08535	COG3250	beta-galactosidase activity
I6H42_RS08540	COG1297	OPT oligopeptide transporter protein
I6H42_RS08555	COG2354	Protein conserved in bacteria
I6H42_RS08560	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H42_RS08600	COG1754	DNA topoisomerase type I activity
I6H42_RS08600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H42_RS08605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H42_RS08625	COG0783	Belongs to the Dps family
I6H42_RS08630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H42_RS08635	COG0038	chloride channel
I6H42_RS08650	COG2885	chlorophyll binding
I6H42_RS08655	COG0588	phosphoglycerate mutase activity
I6H42_RS08660	COG1329	Transcriptional regulator
I6H42_RS08665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H42_RS08705	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H42_RS08715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H42_RS08720	COG0215	cysteine-tRNA ligase activity
I6H42_RS08725	COG1215	transferase activity, transferring glycosyl groups
I6H42_RS08735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H42_RS08770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H42_RS08785	COG0354	folic acid binding
I6H42_RS08790	COG1490	D-aminoacyl-tRNA deacylase activity
I6H42_RS08805	COG0714	Associated with various cellular activities
I6H42_RS08820	COG2815	serine threonine protein kinase
I6H42_RS08820	COG0515	serine threonine protein kinase
I6H42_RS08835	COG0574	Belongs to the PEP-utilizing enzyme family
I6H42_RS08835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H42_RS08840	COG0672	)-iron permease
I6H42_RS08845	COG3470	protein probably involved in high-affinity Fe2 transport
I6H42_RS08855	COG0577	efflux transmembrane transporter activity
I6H42_RS08855	COG1136	(ABC) transporter
I6H42_RS08865	COG1136	(ABC) transporter
I6H42_RS08895	COG0791	NLP P60 protein
I6H42_RS08900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6H42_RS08910	COG0037	tRNA processing
I6H42_RS08920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H42_RS08925	COG0302	gtp cyclohydrolase
I6H42_RS08935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H42_RS08950	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation