locus-tag	class	description
ESZ52_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ESZ52_RS00010	COG0592	DNA-directed DNA polymerase activity
ESZ52_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ESZ52_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ESZ52_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ESZ52_RS00030	COG0187	DNA topoisomerase II activity
ESZ52_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ESZ52_RS00040	COG3266	domain, Protein
ESZ52_RS00045	COG1476	TRANSCRIPTIONal
ESZ52_RS00070	COG3177	Filamentation induced by cAMP protein fic
ESZ52_RS00085	COG1078	dGTPase activity
ESZ52_RS00165	COG2801	Transposase and inactivated derivatives
ESZ52_RS00190	COG1476	TRANSCRIPTIONal
ESZ52_RS00205	COG3328	transposase activity
ESZ52_RS00245	COG0222	ribosome binding
ESZ52_RS00270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ESZ52_RS00275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ESZ52_RS00275	COG2755	lipolytic protein G-D-S-L family
ESZ52_RS00285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ESZ52_RS00305	COG0515	serine threonine protein kinase
ESZ52_RS00310	COG0768	penicillin binding
ESZ52_RS00325	COG1716	ATPase activity
ESZ52_RS00385	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ESZ52_RS00420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ESZ52_RS00420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESZ52_RS00425	COG4106	trans-aconitate 2-methyltransferase activity
ESZ52_RS00430	COG1131	(ABC) transporter
ESZ52_RS00450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ESZ52_RS00470	COG2188	Transcriptional regulator
ESZ52_RS00480	COG4608	Belongs to the ABC transporter superfamily
ESZ52_RS00490	COG0601	transmembrane transport
ESZ52_RS00495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESZ52_RS00515	COG1404	Belongs to the peptidase S8 family
ESZ52_RS00530	COG1966	Carbon starvation protein
ESZ52_RS00540	COG2197	response regulator
ESZ52_RS00545	COG4585	Histidine kinase
ESZ52_RS00550	COG1793	dna ligase
ESZ52_RS00565	COG0702	epimerase
ESZ52_RS00600	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS00640	COG1174	glycine betaine transport
ESZ52_RS00645	COG1174	glycine betaine transport
ESZ52_RS00660	COG0737	Belongs to the 5'-nucleotidase family
ESZ52_RS00660	COG4085	toxin activity
ESZ52_RS00660	COG1525	nuclease
ESZ52_RS00670	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESZ52_RS00670	COG2247	cell wall binding repeat
ESZ52_RS00710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESZ52_RS00820	COG0667	Aldo Keto reductase
ESZ52_RS00845	COG0415	Belongs to the DNA photolyase family
ESZ52_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS00870	COG1960	acyl-CoA dehydrogenase activity
ESZ52_RS00875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ESZ52_RS00885	COG3012	SEC-C Motif Domain Protein
ESZ52_RS00915	COG0569	domain protein
ESZ52_RS00925	COG3091	SprT-like family
ESZ52_RS00930	COG1653	transport
ESZ52_RS00935	COG1175	transmembrane transport
ESZ52_RS00940	COG0395	ABC-type sugar transport system, permease component
ESZ52_RS00945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ESZ52_RS00950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ESZ52_RS00970	COG1215	transferase activity, transferring glycosyl groups
ESZ52_RS00985	COG1597	lipid kinase activity
ESZ52_RS00985	COG1803	Methylglyoxal synthase
ESZ52_RS00990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ESZ52_RS01005	COG4585	Histidine kinase
ESZ52_RS01010	COG2197	response regulator
ESZ52_RS01015	COG4152	abc transporter atp-binding protein
ESZ52_RS01025	COG0561	phosphatase activity
ESZ52_RS01030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESZ52_RS01040	COG2217	Heavy metal translocating P-type atpase
ESZ52_RS01050	COG1937	Protein conserved in bacteria
ESZ52_RS01085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ESZ52_RS01095	COG0501	Belongs to the peptidase M48B family
ESZ52_RS01100	COG0577	efflux transmembrane transporter activity
ESZ52_RS01100	COG1136	(ABC) transporter
ESZ52_RS01105	COG1136	(ABC) transporter
ESZ52_RS01105	COG0577	efflux transmembrane transporter activity
ESZ52_RS01130	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESZ52_RS01145	COG2267	carboxylic ester hydrolase activity
ESZ52_RS01150	COG0813	purine-nucleoside phosphorylase activity
ESZ52_RS01155	COG1215	transferase activity, transferring glycosyl groups
ESZ52_RS01175	COG3250	beta-galactosidase activity
ESZ52_RS01180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ESZ52_RS01215	COG0006	proline dipeptidase activity
ESZ52_RS01280	COG1131	(ABC) transporter
ESZ52_RS01285	COG2801	Transposase and inactivated derivatives
ESZ52_RS01290	COG2963	transposase activity
ESZ52_RS01300	COG0443	Heat shock 70 kDa protein
ESZ52_RS01305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ESZ52_RS01310	COG0484	heat shock protein binding
ESZ52_RS01315	COG0789	Transcriptional regulator
ESZ52_RS01325	COG1131	(ABC) transporter
ESZ52_RS01335	COG2197	response regulator
ESZ52_RS01350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ESZ52_RS01375	COG3025	triphosphatase activity
ESZ52_RS01375	COG5607	PFAM CHAD domain containing protein
ESZ52_RS01390	COG0542	response to heat
ESZ52_RS01410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ESZ52_RS01435	COG0708	Exodeoxyribonuclease III
ESZ52_RS01455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ESZ52_RS01465	COG0586	Pfam SNARE associated Golgi protein
ESZ52_RS01490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ESZ52_RS01515	COG2326	polyphosphate kinase activity
ESZ52_RS01520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ESZ52_RS01520	COG0047	phosphoribosylformylglycinamidine synthase activity
ESZ52_RS01525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ESZ52_RS01530	COG0151	Belongs to the GarS family
ESZ52_RS01550	COG0318	PFAM AMP-dependent synthetase and ligase
ESZ52_RS01550	COG0204	Acyl-transferase
ESZ52_RS01555	COG0546	phosphoglycolate phosphatase activity
ESZ52_RS01560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ESZ52_RS01585	COG1863	multisubunit Na H antiporter MnhE subunit
ESZ52_RS01590	COG0651	ATP synthesis coupled electron transport
ESZ52_RS01595	COG1006	Multisubunit Na H antiporter MnhC subunit
ESZ52_RS01600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ESZ52_RS01600	COG2111	Na H antiporter
ESZ52_RS01610	COG3119	arylsulfatase activity
ESZ52_RS01615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ESZ52_RS01635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ESZ52_RS01635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ESZ52_RS01655	COG0659	secondary active sulfate transmembrane transporter activity
ESZ52_RS01675	COG2076	Multidrug Resistance protein
ESZ52_RS01810	COG0739	heme binding
ESZ52_RS01810	COG0741	lytic transglycosylase activity
ESZ52_RS01810	COG1196	nuclear chromosome segregation
ESZ52_RS01835	COG2801	Transposase and inactivated derivatives
ESZ52_RS01840	COG2197	response regulator
ESZ52_RS01905	COG0305	Participates in initiation and elongation during chromosome replication
ESZ52_RS01905	COG0358	DNA primase activity
ESZ52_RS01930	COG4974	Belongs to the 'phage' integrase family
ESZ52_RS02025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ESZ52_RS02030	COG1408	metallophosphoesterase
ESZ52_RS02035	COG1610	YqeY-like protein
ESZ52_RS02040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESZ52_RS02065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESZ52_RS02070	COG0395	ABC-type sugar transport system, permease component
ESZ52_RS02075	COG1175	transmembrane transport
ESZ52_RS02145	COG1205	dead DEAH box helicase
ESZ52_RS02145	COG1111	helicase
ESZ52_RS02150	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ESZ52_RS02160	COG2890	protein-(glutamine-N5) methyltransferase activity
ESZ52_RS02170	COG1754	DNA topoisomerase type I activity
ESZ52_RS02170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ESZ52_RS02180	COG0626	cystathionine gamma-synthase activity
ESZ52_RS02185	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS02195	COG0789	Transcriptional regulator
ESZ52_RS02200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ESZ52_RS02205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ESZ52_RS02230	COG1131	(ABC) transporter
ESZ52_RS02245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ESZ52_RS02250	COG2027	D-alanyl-D-alanine carboxypeptidase
ESZ52_RS02260	COG0037	tRNA processing
ESZ52_RS02270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ESZ52_RS02275	COG0302	gtp cyclohydrolase
ESZ52_RS02280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ESZ52_RS02285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ESZ52_RS02300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ESZ52_RS02310	COG0649	NAD binding
ESZ52_RS02335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ESZ52_RS02350	COG1793	dna ligase
ESZ52_RS02350	COG3285	dna ligase
ESZ52_RS02355	COG3285	dna ligase
ESZ52_RS02355	COG1793	dna ligase
ESZ52_RS02360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ESZ52_RS02385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ESZ52_RS02400	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ESZ52_RS02415	COG0248	Ppx GppA phosphatase
ESZ52_RS02420	COG1082	Xylose isomerase domain protein TIM barrel
ESZ52_RS02425	COG0506	proline dehydrogenase activity
ESZ52_RS02430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ESZ52_RS02440	COG0123	including yeast histone deacetylase and acetoin utilization protein
ESZ52_RS02460	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ESZ52_RS02465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ESZ52_RS02475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ESZ52_RS02475	COG1648	precorrin-2 dehydrogenase activity
ESZ52_RS02480	COG0113	porphobilinogen synthase activity
ESZ52_RS02490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ESZ52_RS02495	COG0406	alpha-ribazole phosphatase activity
ESZ52_RS02505	COG0785	Cytochrome C biogenesis protein
ESZ52_RS02510	COG1333	cytochrome c biogenesis protein
ESZ52_RS02515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESZ52_RS02570	COG4948	Mandelate Racemase Muconate Lactonizing
ESZ52_RS02585	COG1846	Transcriptional regulator
ESZ52_RS02590	COG1132	(ABC) transporter
ESZ52_RS02600	COG1278	Cold shock
ESZ52_RS02635	COG0259	pyridoxamine-phosphate oxidase activity
ESZ52_RS02640	COG1321	iron dependent repressor
ESZ52_RS02645	COG0791	NLP P60 protein
ESZ52_RS02645	COG1388	LysM domain
ESZ52_RS02645	COG3103	Sh3 type 3 domain protein
ESZ52_RS02660	COG0420	3'-5' exonuclease activity
ESZ52_RS02685	COG1278	Cold shock
ESZ52_RS02695	COG1272	protein, Hemolysin III
ESZ52_RS02700	COG0477	Major facilitator Superfamily
ESZ52_RS02715	COG1970	mechanosensitive ion channel activity
ESZ52_RS02745	COG0315	cyclic pyranopterin monophosphate synthase activity
ESZ52_RS02765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ESZ52_RS02795	COG1053	succinate dehydrogenase
ESZ52_RS02800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ESZ52_RS02845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESZ52_RS02850	COG0084	hydrolase, TatD family'
ESZ52_RS02875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ESZ52_RS02885	COG0488	(ABC) transporter
ESZ52_RS02910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ESZ52_RS02915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ESZ52_RS02920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ESZ52_RS02925	COG0193	aminoacyl-tRNA hydrolase activity
ESZ52_RS02930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ESZ52_RS02935	COG2011	ABC-type metal ion transport system permease component
ESZ52_RS02945	COG1464	Belongs to the NlpA lipoprotein family
ESZ52_RS02965	COG1842	Phage shock protein A
ESZ52_RS02995	COG0148	phosphopyruvate hydratase activity
ESZ52_RS03115	COG0739	heme binding
ESZ52_RS03115	COG0741	lytic transglycosylase activity
ESZ52_RS03115	COG1196	nuclear chromosome segregation
ESZ52_RS03165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ESZ52_RS03180	COG4977	sequence-specific DNA binding
ESZ52_RS03180	COG1917	Cupin 2, conserved barrel domain protein
ESZ52_RS03185	COG0477	Major facilitator Superfamily
ESZ52_RS03195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ESZ52_RS03215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESZ52_RS03255	COG2354	Protein conserved in bacteria
ESZ52_RS03260	COG0183	Belongs to the thiolase family
ESZ52_RS03265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESZ52_RS03270	COG0318	PFAM AMP-dependent synthetase and ligase
ESZ52_RS03275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ESZ52_RS03285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESZ52_RS03295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ESZ52_RS03305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ESZ52_RS03320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ESZ52_RS03325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESZ52_RS03330	COG0765	amino acid transport
ESZ52_RS03340	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ESZ52_RS03360	COG1072	(Pantothenic acid kinase))
ESZ52_RS03370	COG0736	holo-[acyl-carrier-protein] synthase activity
ESZ52_RS03385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ESZ52_RS03390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ESZ52_RS03400	COG0028	Belongs to the TPP enzyme family
ESZ52_RS03405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ESZ52_RS03410	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ESZ52_RS03415	COG2080	2 iron, 2 sulfur cluster binding
ESZ52_RS03420	COG0549	Belongs to the carbamate kinase family
ESZ52_RS03460	COG2233	PERMEase
ESZ52_RS03475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ESZ52_RS03480	COG1304	FMN binding
ESZ52_RS03490	COG0154	amidase activity
ESZ52_RS03510	COG0066	3-isopropylmalate dehydratase activity
ESZ52_RS03515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ESZ52_RS03520	COG0473	3-isopropylmalate dehydrogenase activity
ESZ52_RS03525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ESZ52_RS03530	COG0802	atpase or kinase
ESZ52_RS03535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ESZ52_RS03560	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESZ52_RS03560	COG0567	Dehydrogenase, E1 component
ESZ52_RS03585	COG0018	arginyl-trna synthetase
ESZ52_RS03590	COG0460	homoserine dehydrogenase
ESZ52_RS03600	COG0254	rRNA binding
ESZ52_RS03605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ESZ52_RS03610	COG2890	protein-(glutamine-N5) methyltransferase activity
ESZ52_RS03625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ESZ52_RS03630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESZ52_RS03645	COG0356	it plays a direct role in the translocation of protons across the membrane
ESZ52_RS03650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESZ52_RS03655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ESZ52_RS03660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESZ52_RS03665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ESZ52_RS03670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ESZ52_RS03675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ESZ52_RS03680	COG0427	acetyl-CoA hydrolase
ESZ52_RS03685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ESZ52_RS03710	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ESZ52_RS03715	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESZ52_RS03730	COG0346	lactoylglutathione lyase activity
ESZ52_RS03735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ESZ52_RS03740	COG0183	Belongs to the thiolase family
ESZ52_RS03760	COG0596	Alpha beta hydrolase
ESZ52_RS03775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ESZ52_RS03780	COG0366	Alpha amylase catalytic
ESZ52_RS03785	COG0366	Alpha amylase catalytic
ESZ52_RS03800	COG1024	Enoyl-CoA hydratase
ESZ52_RS03825	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ESZ52_RS03835	COG0482	sulfurtransferase activity
ESZ52_RS03855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ESZ52_RS03860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ESZ52_RS03870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESZ52_RS03875	COG0154	amidase activity
ESZ52_RS03880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESZ52_RS03920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ESZ52_RS03925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ESZ52_RS03940	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESZ52_RS03945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ESZ52_RS03965	COG1234	tRNA 3'-trailer cleavage
ESZ52_RS03975	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ESZ52_RS03985	COG2364	Membrane
ESZ52_RS04005	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ESZ52_RS04010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ESZ52_RS04015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ESZ52_RS04020	COG0083	homoserine kinase activity
ESZ52_RS04025	COG0384	phenazine biosynthesis protein PhzF
ESZ52_RS04030	COG2755	lipolytic protein G-D-S-L family
ESZ52_RS04050	COG0156	8-amino-7-oxononanoate synthase activity
ESZ52_RS04055	COG1063	alcohol dehydrogenase
ESZ52_RS04070	COG1295	ribonuclease BN
ESZ52_RS04110	COG3845	ABC transporter
ESZ52_RS04115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ESZ52_RS04130	COG0542	response to heat
ESZ52_RS04150	COG1196	nuclear chromosome segregation
ESZ52_RS04180	COG0791	NLP P60 protein
ESZ52_RS04180	COG1388	LysM domain
ESZ52_RS04180	COG3103	Sh3 type 3 domain protein
ESZ52_RS04205	COG1937	Protein conserved in bacteria
ESZ52_RS04225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ESZ52_RS04230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ESZ52_RS04240	COG0662	Cupin 2, conserved barrel domain protein
ESZ52_RS04260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESZ52_RS04270	COG0785	Cytochrome C biogenesis protein
ESZ52_RS04305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ESZ52_RS04315	COG1937	Protein conserved in bacteria
ESZ52_RS04330	COG5002	protein histidine kinase activity
ESZ52_RS04335	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS04345	COG2132	Multicopper oxidase
ESZ52_RS04365	COG1937	Protein conserved in bacteria
ESZ52_RS04445	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ESZ52_RS04455	COG0372	Belongs to the citrate synthase family
ESZ52_RS04460	COG0372	Belongs to the citrate synthase family
ESZ52_RS04465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ESZ52_RS04475	COG1404	Belongs to the peptidase S8 family
ESZ52_RS04485	COG1605	Chorismate mutase
ESZ52_RS04485	COG0287	Prephenate dehydrogenase
ESZ52_RS04510	COG0564	pseudouridine synthase activity
ESZ52_RS04520	COG1404	Belongs to the peptidase S8 family
ESZ52_RS04525	COG1946	Acyl-CoA thioesterase
ESZ52_RS04535	COG1556	Lactate utilization protein
ESZ52_RS04540	COG1139	Iron-sulfur cluster binding protein
ESZ52_RS04545	COG0247	lactate metabolic process
ESZ52_RS04565	COG1278	Cold shock
ESZ52_RS04580	COG1253	flavin adenine dinucleotide binding
ESZ52_RS04590	COG0366	Alpha amylase catalytic
ESZ52_RS04595	COG2346	COG2346, Truncated hemoglobins
ESZ52_RS04605	COG0668	transmembrane transport
ESZ52_RS04625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ESZ52_RS04635	COG2239	Acts as a magnesium transporter
ESZ52_RS04655	COG0544	peptidyl-prolyl cis-trans isomerase activity
ESZ52_RS04670	COG0740	serine-type endopeptidase activity
ESZ52_RS04675	COG0740	serine-type endopeptidase activity
ESZ52_RS04680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ESZ52_RS04695	COG0714	Associated with various cellular activities
ESZ52_RS04710	COG0525	valine-tRNA ligase activity
ESZ52_RS04715	COG1115	amino acid carrier protein
ESZ52_RS04720	COG0277	FAD linked oxidase domain protein
ESZ52_RS04730	COG0285	dihydrofolate synthase activity
ESZ52_RS04750	COG1968	undecaprenyl-diphosphatase activity
ESZ52_RS04755	COG0105	UTP biosynthetic process
ESZ52_RS04790	COG0768	penicillin binding
ESZ52_RS04795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ESZ52_RS04820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ESZ52_RS04825	COG1185	polyribonucleotide nucleotidyltransferase activity
ESZ52_RS04850	COG3396	Phenylacetate-CoA oxygenase
ESZ52_RS04855	COG3460	Phenylacetate-CoA oxygenase
ESZ52_RS04860	COG3396	Phenylacetate-CoA oxygenase
ESZ52_RS04865	COG2151	metal-sulfur cluster biosynthetic enzyme
ESZ52_RS04870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ESZ52_RS04875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESZ52_RS04880	COG0424	maF-like protein
ESZ52_RS04900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ESZ52_RS04910	COG1024	Enoyl-CoA hydratase
ESZ52_RS04915	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS04940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS04955	COG2815	serine threonine protein kinase
ESZ52_RS04955	COG0515	serine threonine protein kinase
ESZ52_RS04960	COG1316	TRANSCRIPTIONal
ESZ52_RS04990	COG0778	Nitroreductase
ESZ52_RS04990	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ESZ52_RS04995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ESZ52_RS05025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESZ52_RS05030	COG1663	tetraacyldisaccharide 4'-kinase activity
ESZ52_RS05030	COG2835	tetraacyldisaccharide 4'-kinase activity
ESZ52_RS05045	COG3483	tryptophan 2,3-dioxygenase activity
ESZ52_RS05060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ESZ52_RS05065	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS05070	COG5002	protein histidine kinase activity
ESZ52_RS05070	COG5000	phosphorelay sensor kinase activity
ESZ52_RS05075	COG5401	PFAM Sporulation and spore germination
ESZ52_RS05085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ESZ52_RS05090	COG3214	Protein conserved in bacteria
ESZ52_RS05095	COG0653	protein targeting
ESZ52_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
ESZ52_RS05155	COG2902	Dehydrogenase
ESZ52_RS05170	COG1228	amidohydrolase
ESZ52_RS05190	COG0574	Belongs to the PEP-utilizing enzyme family
ESZ52_RS05190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ESZ52_RS05195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ESZ52_RS05205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ESZ52_RS05215	COG2813	Specifically methylates the guanine in position
ESZ52_RS05220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ESZ52_RS05235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ESZ52_RS05260	COG0798	PFAM Bile acid sodium symporter
ESZ52_RS05275	COG2226	methyltransferase
ESZ52_RS05300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ESZ52_RS05305	COG0268	Binds directly to 16S ribosomal RNA
ESZ52_RS05310	COG0495	leucyl-tRNA aminoacylation
ESZ52_RS05315	COG1307	EDD domain protein, DegV family
ESZ52_RS05320	COG1555	photosystem II stabilization
ESZ52_RS05320	COG1596	polysaccharide export
ESZ52_RS05575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ESZ52_RS05580	COG1234	tRNA 3'-trailer cleavage
ESZ52_RS05585	COG0583	DNA-binding transcription factor activity
ESZ52_RS05590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ESZ52_RS05605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ESZ52_RS05635	COG2226	methyltransferase
ESZ52_RS05650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS05680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ESZ52_RS05685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESZ52_RS05710	COG3344	reverse transcriptase
ESZ52_RS05720	COG3547	Transposase (IS116 IS110 IS902 family)
ESZ52_RS05780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS05790	COG2814	Major facilitator Superfamily
ESZ52_RS05800	COG1129	ABC transporter
ESZ52_RS05805	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESZ52_RS05825	COG0673	inositol 2-dehydrogenase activity
ESZ52_RS05850	COG2353	YceI-like domain
ESZ52_RS05860	COG0723	plastoquinol--plastocyanin reductase activity
ESZ52_RS05865	COG0572	uridine kinase
ESZ52_RS05870	COG1070	Carbohydrate kinase
ESZ52_RS05875	COG1063	alcohol dehydrogenase
ESZ52_RS05880	COG1063	alcohol dehydrogenase
ESZ52_RS05890	COG0395	ABC-type sugar transport system, permease component
ESZ52_RS05925	COG2031	fatty acid transporter
ESZ52_RS05930	COG1063	alcohol dehydrogenase
ESZ52_RS05940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS05955	COG1725	Transcriptional regulator
ESZ52_RS05980	COG1716	ATPase activity
ESZ52_RS06030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ESZ52_RS06050	COG2733	membrane
ESZ52_RS06070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS06095	COG1643	Atp-dependent helicase
ESZ52_RS06100	COG1228	amidohydrolase
ESZ52_RS06105	COG0402	S-adenosylhomocysteine deaminase activity
ESZ52_RS06110	COG1660	Displays ATPase and GTPase activities
ESZ52_RS06120	COG3314	Sporulation integral membrane protein YlbJ
ESZ52_RS06125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ESZ52_RS06130	COG2154	pterin-4-alpha-carbinolamine dehydratase
ESZ52_RS06135	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ESZ52_RS06135	COG0237	dephospho-CoA kinase activity
ESZ52_RS06150	COG1506	peptidase
ESZ52_RS06150	COG0823	Involved in the tonB-independent uptake of proteins
ESZ52_RS06170	COG0589	response to stress
ESZ52_RS06180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ESZ52_RS06205	COG0714	Associated with various cellular activities
ESZ52_RS06210	COG2001	Belongs to the MraZ family
ESZ52_RS06215	COG0275	rRNA processing
ESZ52_RS06225	COG0768	penicillin binding
ESZ52_RS06235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESZ52_RS06240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ESZ52_RS06250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ESZ52_RS06255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ESZ52_RS06260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ESZ52_RS06265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ESZ52_RS06290	COG2894	cell division
ESZ52_RS06315	COG1496	oxidoreductase activity
ESZ52_RS06325	COG1799	cell septum assembly
ESZ52_RS06345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ESZ52_RS06355	COG0587	DNA-directed DNA polymerase activity
ESZ52_RS06370	COG4166	transmembrane transport
ESZ52_RS06375	COG0601	transmembrane transport
ESZ52_RS06380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESZ52_RS06390	COG4608	Belongs to the ABC transporter superfamily
ESZ52_RS06400	COG4129	membrane
ESZ52_RS06430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ESZ52_RS06440	COG0590	tRNA wobble adenosine to inosine editing
ESZ52_RS06440	COG0037	tRNA processing
ESZ52_RS06445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ESZ52_RS06460	COG0321	lipoyl(octanoyl) transferase activity
ESZ52_RS06465	COG0515	serine threonine protein kinase
ESZ52_RS06465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ESZ52_RS06475	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESZ52_RS06480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESZ52_RS06485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ESZ52_RS06490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ESZ52_RS06510	COG0435	Glutathione S-transferase
ESZ52_RS06515	COG0180	Tryptophanyl-tRNA synthetase
ESZ52_RS06530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ESZ52_RS06535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ESZ52_RS06540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ESZ52_RS06555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ESZ52_RS06565	COG1845	cytochrome c oxidase, subunit III
ESZ52_RS06575	COG0723	plastoquinol--plastocyanin reductase activity
ESZ52_RS06580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ESZ52_RS06610	COG1940	carbohydrate kinase activity
ESZ52_RS06615	COG1940	carbohydrate kinase activity
ESZ52_RS06630	COG0204	Acyl-transferase
ESZ52_RS06630	COG0318	PFAM AMP-dependent synthetase and ligase
ESZ52_RS06635	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ESZ52_RS06645	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ESZ52_RS06650	COG2815	serine threonine protein kinase
ESZ52_RS06650	COG0515	serine threonine protein kinase
ESZ52_RS06655	COG1388	LysM domain
ESZ52_RS06655	COG3942	CHAP domain
ESZ52_RS06665	COG0142	geranyltranstransferase activity
ESZ52_RS06680	COG0587	DNA-directed DNA polymerase activity
ESZ52_RS06685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESZ52_RS06705	COG0187	DNA topoisomerase II activity
ESZ52_RS06710	COG0513	Belongs to the DEAD box helicase family
ESZ52_RS06715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ESZ52_RS06730	COG0733	neurotransmitter:sodium symporter activity
ESZ52_RS06735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ESZ52_RS06775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS06775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS06775	COG1703	isobutyryl-CoA mutase activity
ESZ52_RS06790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESZ52_RS06795	COG3268	Saccharopine dehydrogenase
ESZ52_RS06815	COG2755	lipolytic protein G-D-S-L family
ESZ52_RS06815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ESZ52_RS06825	COG1012	belongs to the aldehyde dehydrogenase family
ESZ52_RS06830	COG1012	belongs to the aldehyde dehydrogenase family
ESZ52_RS06865	COG1012	belongs to the aldehyde dehydrogenase family
ESZ52_RS06870	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ESZ52_RS06880	COG3387	PFAM Glycoside hydrolase 15-related
ESZ52_RS06885	COG0513	Belongs to the DEAD box helicase family
ESZ52_RS06895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ESZ52_RS06900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ESZ52_RS06905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ESZ52_RS06905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESZ52_RS06910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ESZ52_RS06920	COG1960	acyl-CoA dehydrogenase activity
ESZ52_RS06925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESZ52_RS06935	COG2855	membrane
ESZ52_RS06940	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ESZ52_RS06945	COG1691	(AIR) carboxylase
ESZ52_RS06950	COG1606	tRNA processing
ESZ52_RS06955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ESZ52_RS06960	COG1609	Transcriptional regulator
ESZ52_RS06970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ESZ52_RS06975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ESZ52_RS06975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ESZ52_RS06985	COG1904	glucuronate isomerase
ESZ52_RS06990	COG0246	Mannitol dehydrogenase
ESZ52_RS06995	COG0588	phosphoglycerate mutase activity
ESZ52_RS07015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ESZ52_RS07055	COG0596	Alpha beta hydrolase
ESZ52_RS07060	COG0432	Pfam Uncharacterised protein family UPF0047
ESZ52_RS07065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ESZ52_RS07090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ESZ52_RS07135	COG0778	Nitroreductase
ESZ52_RS07160	COG1435	thymidine kinase activity
ESZ52_RS07170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ESZ52_RS07185	COG0756	dUTP diphosphatase activity
ESZ52_RS07200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ESZ52_RS07205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ESZ52_RS07210	COG2514	catechol 2,3-dioxygenase activity
ESZ52_RS07215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS07245	COG2326	polyphosphate kinase activity
ESZ52_RS07265	COG1597	lipid kinase activity
ESZ52_RS07280	COG1757	Na H antiporter
ESZ52_RS07310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ESZ52_RS07315	COG0673	inositol 2-dehydrogenase activity
ESZ52_RS07325	COG0351	phosphomethylpyrimidine kinase
ESZ52_RS07330	COG0352	thiamine-phosphate diphosphorylase activity
ESZ52_RS07335	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ESZ52_RS07350	COG1132	(ABC) transporter
ESZ52_RS07415	COG2267	carboxylic ester hydrolase activity
ESZ52_RS07420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ESZ52_RS07455	COG4589	Belongs to the CDS family
ESZ52_RS07470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ESZ52_RS07485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ESZ52_RS07490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ESZ52_RS07500	COG0488	(ABC) transporter
ESZ52_RS07505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ESZ52_RS07520	COG3253	May function as heme-dependent peroxidase
ESZ52_RS07525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESZ52_RS07530	COG1793	dna ligase
ESZ52_RS07530	COG3285	dna ligase
ESZ52_RS07535	COG1793	dna ligase
ESZ52_RS07545	COG2326	polyphosphate kinase activity
ESZ52_RS07600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ESZ52_RS07715	COG2337	Toxic component of a toxin-antitoxin (TA) module
ESZ52_RS07720	COG1136	(ABC) transporter
ESZ52_RS07770	COG2409	Drug exporters of the RND superfamily
ESZ52_RS07780	COG2197	response regulator
ESZ52_RS07820	COG0739	heme binding
ESZ52_RS07820	COG0741	lytic transglycosylase activity
ESZ52_RS07820	COG1196	nuclear chromosome segregation
ESZ52_RS07865	COG1136	(ABC) transporter
ESZ52_RS07890	COG0789	Transcriptional regulator
ESZ52_RS07915	COG1230	cation diffusion facilitator family transporter
ESZ52_RS07945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ESZ52_RS07955	COG0785	Cytochrome C biogenesis protein
ESZ52_RS07965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESZ52_RS08015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ESZ52_RS08020	COG1294	oxidase, subunit
ESZ52_RS08025	COG1271	oxidase subunit
ESZ52_RS08040	COG0739	heme binding
ESZ52_RS08060	COG3336	cytochrome c oxidase
ESZ52_RS08075	COG0640	Transcriptional regulator
ESZ52_RS08080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESZ52_RS08085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ESZ52_RS08165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ESZ52_RS08210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESZ52_RS08230	COG1335	isochorismatase
ESZ52_RS08235	COG1051	belongs to the nudix hydrolase family
ESZ52_RS08270	COG0640	Transcriptional regulator
ESZ52_RS08275	COG0346	lactoylglutathione lyase activity
ESZ52_RS08310	COG3546	catalase activity
ESZ52_RS08325	COG1058	Belongs to the CinA family
ESZ52_RS08325	COG1546	Belongs to the CinA family
ESZ52_RS08330	COG0028	Belongs to the TPP enzyme family
ESZ52_RS08340	COG1012	belongs to the aldehyde dehydrogenase family
ESZ52_RS08345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESZ52_RS08350	COG0601	transmembrane transport
ESZ52_RS08360	COG0444	Belongs to the ABC transporter superfamily
ESZ52_RS08370	COG1725	Transcriptional regulator
ESZ52_RS08380	COG0747	negative chemotaxis
ESZ52_RS08410	COG2247	cell wall binding repeat
ESZ52_RS08410	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESZ52_RS08430	COG2115	Belongs to the xylose isomerase family
ESZ52_RS08440	COG1175	transmembrane transport
ESZ52_RS08450	COG1472	Belongs to the glycosyl hydrolase 3 family
ESZ52_RS08465	COG2017	converts alpha-aldose to the beta-anomer
ESZ52_RS08470	COG1960	acyl-CoA dehydrogenase activity
ESZ52_RS08495	COG4948	Mandelate Racemase Muconate Lactonizing
ESZ52_RS08500	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ESZ52_RS08505	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ESZ52_RS08505	COG2508	Transcriptional regulator
ESZ52_RS08520	COG0444	Belongs to the ABC transporter superfamily
ESZ52_RS08575	COG1063	alcohol dehydrogenase
ESZ52_RS08590	COG2267	carboxylic ester hydrolase activity
ESZ52_RS08630	COG4608	Belongs to the ABC transporter superfamily
ESZ52_RS08645	COG0747	negative chemotaxis
ESZ52_RS08650	COG0747	negative chemotaxis
ESZ52_RS08655	COG0747	negative chemotaxis
ESZ52_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS08665	COG0747	negative chemotaxis
ESZ52_RS08670	COG0196	riboflavin kinase activity
ESZ52_RS08675	COG0596	Alpha beta hydrolase
ESZ52_RS08675	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESZ52_RS08695	COG1960	acyl-CoA dehydrogenase activity
ESZ52_RS08705	COG0183	Belongs to the thiolase family
ESZ52_RS08710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESZ52_RS08715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESZ52_RS08720	COG0281	malic enzyme
ESZ52_RS08725	COG1984	allophanate hydrolase subunit 2
ESZ52_RS08735	COG1914	H( )-stimulated, divalent metal cation uptake system
ESZ52_RS08765	COG1131	(ABC) transporter
ESZ52_RS08800	COG1183	phosphatidylcholine synthase activity
ESZ52_RS08805	COG4946	Tricorn protease homolog
ESZ52_RS08805	COG0793	Belongs to the peptidase S41A family
ESZ52_RS08825	COG0596	Alpha beta hydrolase
ESZ52_RS08865	COG2860	membrane
ESZ52_RS08870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESZ52_RS08885	COG0318	PFAM AMP-dependent synthetase and ligase
ESZ52_RS08920	COG0247	lactate metabolic process
ESZ52_RS08920	COG0277	FAD linked oxidase domain protein
ESZ52_RS08925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ESZ52_RS08935	COG1024	Enoyl-CoA hydratase
ESZ52_RS08950	COG4585	Histidine kinase
ESZ52_RS08955	COG2197	response regulator
ESZ52_RS09015	COG3842	ATPase activity
ESZ52_RS09025	COG1176	ABC-type spermidine putrescine transport system, permease component I
ESZ52_RS09030	COG1802	Transcriptional regulator
ESZ52_RS09115	COG0110	maltose O-acetyltransferase activity
ESZ52_RS09155	COG0018	arginyl-trna synthetase
ESZ52_RS09160	COG3547	Transposase (IS116 IS110 IS902 family)
ESZ52_RS09195	COG2337	Toxic component of a toxin-antitoxin (TA) module
ESZ52_RS09250	COG1222	aaa ATPase
ESZ52_RS09255	COG1764	response to oxidative stress
ESZ52_RS09260	COG1846	Transcriptional regulator
ESZ52_RS09265	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS09270	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS09285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESZ52_RS09290	COG0626	cystathionine gamma-synthase activity
ESZ52_RS09295	COG0596	Alpha beta hydrolase
ESZ52_RS09295	COG2945	thiolester hydrolase activity
ESZ52_RS09365	COG0492	ferredoxin-NADP+ reductase activity
ESZ52_RS09370	COG0385	Bile acid
ESZ52_RS09380	COG1053	succinate dehydrogenase
ESZ52_RS09400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ESZ52_RS09415	COG0747	negative chemotaxis
ESZ52_RS09435	COG0436	Aminotransferase
ESZ52_RS09445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ESZ52_RS09455	COG2197	response regulator
ESZ52_RS09490	COG4249	Peptidase C14 caspase catalytic subunit p20
ESZ52_RS09490	COG2319	Wd-40 repeat
ESZ52_RS09520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ESZ52_RS09525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ESZ52_RS09535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ESZ52_RS09585	COG0477	Major facilitator Superfamily
ESZ52_RS09590	COG0431	NADPH-dependent FMN reductase
ESZ52_RS09605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ESZ52_RS09645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ESZ52_RS09675	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ESZ52_RS09680	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ESZ52_RS09685	COG0217	transcriptional regulatory protein
ESZ52_RS09690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ESZ52_RS09695	COG0632	four-way junction helicase activity
ESZ52_RS09700	COG2255	four-way junction helicase activity
ESZ52_RS09710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESZ52_RS09715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESZ52_RS09720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ESZ52_RS09725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ESZ52_RS09730	COG1362	aminopeptidase activity
ESZ52_RS09735	COG1196	nuclear chromosome segregation
ESZ52_RS09745	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ESZ52_RS09750	COG0124	histidyl-tRNA synthetase
ESZ52_RS09765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ESZ52_RS09770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ESZ52_RS09775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ESZ52_RS09780	COG0131	Imidazoleglycerol-phosphate dehydratase
ESZ52_RS09780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ESZ52_RS09785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ESZ52_RS09795	COG0107	imidazoleglycerol-phosphate synthase activity
ESZ52_RS09835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ESZ52_RS09840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ESZ52_RS09850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ESZ52_RS09865	COG1160	GTP binding
ESZ52_RS09895	COG0509	glycine decarboxylation via glycine cleavage system
ESZ52_RS09920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ESZ52_RS09920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ESZ52_RS09940	COG0456	acetyltransferase
ESZ52_RS09945	COG0596	Alpha beta hydrolase
ESZ52_RS09950	COG0009	L-threonylcarbamoyladenylate synthase
ESZ52_RS09980	COG2985	domain, Protein
ESZ52_RS09980	COG0569	domain protein
ESZ52_RS10010	COG2267	carboxylic ester hydrolase activity
ESZ52_RS10055	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
ESZ52_RS10070	COG2011	ABC-type metal ion transport system permease component
ESZ52_RS10085	COG0537	adenosine 5'-monophosphoramidase activity
ESZ52_RS10135	COG0463	Glycosyl transferase, family 2
ESZ52_RS10145	COG1607	acyl-coa hydrolase
ESZ52_RS10150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS10155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ESZ52_RS10160	COG0604	alcohol dehydrogenase
ESZ52_RS10170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ESZ52_RS10175	COG1619	proteins homologs of microcin C7 resistance protein MccF
ESZ52_RS10180	COG1522	sequence-specific DNA binding
ESZ52_RS10190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESZ52_RS10215	COG0805	protein transport
ESZ52_RS10220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ESZ52_RS10225	COG2378	regulation of single-species biofilm formation
ESZ52_RS10240	COG2066	Belongs to the glutaminase family
ESZ52_RS10255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ESZ52_RS10270	COG1309	transcriptional regulator
ESZ52_RS10275	COG0477	Major facilitator Superfamily
ESZ52_RS10290	COG1222	aaa ATPase
ESZ52_RS10310	COG1994	Peptidase M50
ESZ52_RS10310	COG0517	IMP dehydrogenase activity
ESZ52_RS10325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESZ52_RS10330	COG0215	cysteine-tRNA ligase activity
ESZ52_RS10355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS10375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESZ52_RS10445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ESZ52_RS10450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ESZ52_RS10470	COG2755	lipolytic protein G-D-S-L family
ESZ52_RS10475	COG2706	6-phosphogluconolactonase activity
ESZ52_RS10500	COG1175	transmembrane transport
ESZ52_RS10505	COG0395	ABC-type sugar transport system, permease component
ESZ52_RS10515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ESZ52_RS10520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS10530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESZ52_RS10535	COG0488	(ABC) transporter
ESZ52_RS10555	COG1404	Belongs to the peptidase S8 family
ESZ52_RS10555	COG4412	M6 family metalloprotease domain protein
ESZ52_RS10560	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ESZ52_RS10580	COG3657	addiction module killer protein
ESZ52_RS10585	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESZ52_RS10595	COG2361	Protein of unknown function DUF86
ESZ52_RS10600	COG2337	Toxic component of a toxin-antitoxin (TA) module
ESZ52_RS10605	COG3609	addiction module antidote protein, CC2985 family
ESZ52_RS10675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESZ52_RS10680	COG1881	PFAM PEBP family protein
ESZ52_RS10700	COG1119	ATPase activity
ESZ52_RS10710	COG2031	fatty acid transporter
ESZ52_RS10715	COG0297	glycogen (starch) synthase activity
ESZ52_RS10730	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS10755	COG1132	(ABC) transporter
ESZ52_RS10760	COG0488	(ABC) transporter
ESZ52_RS10785	COG2151	metal-sulfur cluster biosynthetic enzyme
ESZ52_RS10790	COG0822	iron-sulfur transferase activity
ESZ52_RS10800	COG0396	ATPase activity
ESZ52_RS10835	COG1073	alpha beta
ESZ52_RS10840	COG1612	heme a metabolic process
ESZ52_RS10845	COG0109	protoheme IX farnesyltransferase activity
ESZ52_RS10855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ESZ52_RS10860	COG0166	Belongs to the GPI family
ESZ52_RS10880	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ESZ52_RS10885	COG0149	triose-phosphate isomerase activity
ESZ52_RS10890	COG0126	phosphoglycerate kinase activity
ESZ52_RS10895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ESZ52_RS10900	COG1481	regulation of sporulation
ESZ52_RS10910	COG1660	Displays ATPase and GTPase activities
ESZ52_RS10915	COG0322	excinuclease ABC activity
ESZ52_RS10925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ESZ52_RS10930	COG0067	glutamate synthase
ESZ52_RS10930	COG0069	glutamate synthase activity
ESZ52_RS10930	COG0070	glutamate synthase
ESZ52_RS10945	COG5006	permease, DMT superfamily
ESZ52_RS10950	COG0556	nucleotide-excision repair
ESZ52_RS10960	COG0539	negative regulation of cytoplasmic translation
ESZ52_RS10965	COG2226	methyltransferase
ESZ52_RS11035	COG0159	tryptophan synthase activity
ESZ52_RS11040	COG0133	tryptophan synthase activity
ESZ52_RS11045	COG0134	indole-3-glycerol-phosphate synthase activity
ESZ52_RS11055	COG1132	(ABC) transporter
ESZ52_RS11060	COG1132	(ABC) transporter
ESZ52_RS11075	COG3201	nicotinamide mononucleotide transporter
ESZ52_RS11080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ESZ52_RS11090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ESZ52_RS11095	COG4172	Belongs to the ABC transporter superfamily
ESZ52_RS11110	COG0747	negative chemotaxis
ESZ52_RS11130	COG1758	RNA polymerase activity
ESZ52_RS11135	COG0194	GDP metabolic process
ESZ52_RS11145	COG0284	orotidine-5'-phosphate decarboxylase activity
ESZ52_RS11160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ESZ52_RS11170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ESZ52_RS11175	COG0540	Belongs to the ATCase OTCase family
ESZ52_RS11180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ESZ52_RS11190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ESZ52_RS11195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ESZ52_RS11200	COG0069	glutamate synthase activity
ESZ52_RS11205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ESZ52_RS11210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ESZ52_RS11215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ESZ52_RS11225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ESZ52_RS11240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ESZ52_RS11270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ESZ52_RS11275	COG0494	nUDIX hydrolase
ESZ52_RS11280	COG0504	CTP synthase activity
ESZ52_RS11285	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS11310	COG0497	DNA recombination
ESZ52_RS11315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ESZ52_RS11330	COG0647	UMP catabolic process
ESZ52_RS11355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ESZ52_RS11360	COG2094	Belongs to the DNA glycosylase MPG family
ESZ52_RS11365	COG0165	Argininosuccinate lyase
ESZ52_RS11370	COG1438	arginine binding
ESZ52_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS11385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESZ52_RS11385	COG0072	phenylalanine-tRNA ligase activity
ESZ52_RS11390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ESZ52_RS11405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ESZ52_RS11410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ESZ52_RS11415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ESZ52_RS11420	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS11445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ESZ52_RS11460	COG0174	glutamine synthetase
ESZ52_RS11500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ESZ52_RS11500	COG2146	nitrite reductase [NAD(P)H] activity
ESZ52_RS11520	COG0557	exoribonuclease II activity
ESZ52_RS11525	COG3022	response to hydroperoxide
ESZ52_RS11545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ESZ52_RS11565	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ESZ52_RS11570	COG0584	glycerophosphoryl diester phosphodiesterase
ESZ52_RS11585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ESZ52_RS11590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ESZ52_RS11600	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS11620	COG1126	abc transporter atp-binding protein
ESZ52_RS11625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESZ52_RS11630	COG0765	amino acid transport
ESZ52_RS11635	COG0765	amino acid transport
ESZ52_RS11650	COG0358	DNA primase activity
ESZ52_RS11655	COG0477	Major facilitator Superfamily
ESZ52_RS11680	COG2070	2-Nitropropane dioxygenase
ESZ52_RS11750	COG0693	protein deglycase activity
ESZ52_RS11775	COG1595	DNA-templated transcription, initiation
ESZ52_RS11780	COG0423	glycine-tRNA ligase activity
ESZ52_RS11800	COG1121	(ABC) transporter
ESZ52_RS11815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ESZ52_RS11820	COG1381	Involved in DNA repair and RecF pathway recombination
ESZ52_RS11835	COG1461	Dihydroxyacetone kinase
ESZ52_RS11840	COG2376	Dihydroxyacetone kinase
ESZ52_RS11855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ESZ52_RS11865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ESZ52_RS11885	COG0484	heat shock protein binding
ESZ52_RS11890	COG1420	regulation of RNA biosynthetic process
ESZ52_RS11895	COG0114	fumarate hydratase activity
ESZ52_RS11940	COG2326	polyphosphate kinase activity
ESZ52_RS11945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ESZ52_RS11950	COG0481	GTPase activity
ESZ52_RS11960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ESZ52_RS11965	COG0277	FAD linked oxidase domain protein
ESZ52_RS11970	COG0277	FAD linked oxidase domain protein
ESZ52_RS11975	COG0247	lactate metabolic process
ESZ52_RS11980	COG1620	l-lactate permease
ESZ52_RS11990	COG0406	alpha-ribazole phosphatase activity
ESZ52_RS11995	COG0799	negative regulation of ribosome biogenesis
ESZ52_RS12000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ESZ52_RS12010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ESZ52_RS12015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ESZ52_RS12020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ESZ52_RS12025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ESZ52_RS12030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ESZ52_RS12035	COG1530	ribonuclease E activity
ESZ52_RS12050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ESZ52_RS12070	COG0772	Belongs to the SEDS family
ESZ52_RS12080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ESZ52_RS12085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ESZ52_RS12090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ESZ52_RS12090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ESZ52_RS12105	COG0779	Required for maturation of 30S ribosomal subunits
ESZ52_RS12125	COG1331	Highly conserved protein containing a thioredoxin domain
ESZ52_RS12145	COG0442	prolyl-tRNA aminoacylation
ESZ52_RS12190	COG1505	serine-type exopeptidase activity
ESZ52_RS12200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ESZ52_RS12205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ESZ52_RS12220	COG0456	acetyltransferase
ESZ52_RS12230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ESZ52_RS12235	COG0750	zinc metalloprotease
ESZ52_RS12275	COG3655	Transcriptional regulator
ESZ52_RS12280	COG2318	DinB family
ESZ52_RS12285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ESZ52_RS12290	COG0575	Belongs to the CDS family
ESZ52_RS12295	COG0233	cytoplasmic translational termination
ESZ52_RS12300	COG0528	UMP kinase activity
ESZ52_RS12305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ESZ52_RS12310	COG0052	Belongs to the universal ribosomal protein uS2 family
ESZ52_RS12345	COG0792	nuclease activity
ESZ52_RS12355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ESZ52_RS12375	COG0560	Phosphoserine phosphatase
ESZ52_RS12375	COG3830	Belongs to the UPF0237 family
ESZ52_RS12380	COG0336	Belongs to the RNA methyltransferase TrmD family
ESZ52_RS12385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ESZ52_RS12390	COG1837	Belongs to the UPF0109 family
ESZ52_RS12395	COG0228	four-way junction DNA binding
ESZ52_RS12410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ESZ52_RS12475	COG1254	Belongs to the acylphosphatase family
ESZ52_RS12490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESZ52_RS12495	COG0571	ribonuclease III activity
ESZ52_RS12500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ESZ52_RS12510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ESZ52_RS12520	COG0742	ribosomal rna small subunit methyltransferase
ESZ52_RS12530	COG1461	Dihydroxyacetone kinase
ESZ52_RS12535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ESZ52_RS12540	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ESZ52_RS12555	COG1181	Belongs to the D-alanine--D-alanine ligase family
ESZ52_RS12560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ESZ52_RS12570	COG1920	GTP binding
ESZ52_RS12580	COG0776	regulation of translation
ESZ52_RS12595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ESZ52_RS12605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ESZ52_RS12625	COG0667	Aldo Keto reductase
ESZ52_RS12635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ESZ52_RS12635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESZ52_RS12660	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ESZ52_RS12690	COG2133	pyrroloquinoline quinone binding
ESZ52_RS12695	COG1678	Uncharacterized ACR, COG1678
ESZ52_RS12715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESZ52_RS12720	COG0601	transmembrane transport
ESZ52_RS12730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESZ52_RS12750	COG1595	DNA-templated transcription, initiation
ESZ52_RS12760	COG2026	Addiction module toxin, RelE StbE family
ESZ52_RS12765	COG2161	toxin-antitoxin pair type II binding
ESZ52_RS12820	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ESZ52_RS12830	COG2217	Heavy metal translocating P-type atpase
ESZ52_RS12835	COG2217	Heavy metal translocating P-type atpase
ESZ52_RS12860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESZ52_RS12880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ESZ52_RS12885	COG1196	nuclear chromosome segregation
ESZ52_RS12885	COG0741	lytic transglycosylase activity
ESZ52_RS12885	COG0739	heme binding
ESZ52_RS12895	COG2884	Cell division ATP-binding protein ftsE
ESZ52_RS12915	COG1012	belongs to the aldehyde dehydrogenase family
ESZ52_RS12925	COG1320	monovalent cation:proton antiporter activity
ESZ52_RS12940	COG1007	ATP synthesis coupled electron transport
ESZ52_RS12945	COG0651	ATP synthesis coupled electron transport
ESZ52_RS12950	COG0651	ATP synthesis coupled electron transport
ESZ52_RS12960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ESZ52_RS12975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESZ52_RS13015	COG1674	ftsk spoiiie
ESZ52_RS13045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ESZ52_RS13065	COG2137	regulation of response to DNA damage stimulus
ESZ52_RS13070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ESZ52_RS13100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ESZ52_RS13100	COG0825	malonyl-CoA metabolic process
ESZ52_RS13105	COG1132	(ABC) transporter
ESZ52_RS13110	COG1132	(ABC) transporter
ESZ52_RS13120	COG1201	RNA secondary structure unwinding
ESZ52_RS13140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESZ52_RS13145	COG1396	sequence-specific DNA binding
ESZ52_RS13150	COG1058	Belongs to the CinA family
ESZ52_RS13150	COG1546	Belongs to the CinA family
ESZ52_RS13160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ESZ52_RS13165	COG1674	ftsk spoiiie
ESZ52_RS13175	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ESZ52_RS13180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ESZ52_RS13190	COG0823	Involved in the tonB-independent uptake of proteins
ESZ52_RS13190	COG1506	peptidase
ESZ52_RS13190	COG4946	Tricorn protease homolog
ESZ52_RS13200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ESZ52_RS13205	COG1960	acyl-CoA dehydrogenase activity
ESZ52_RS13210	COG0789	Transcriptional regulator
ESZ52_RS13215	COG4770	biotin carboxylase activity
ESZ52_RS13230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESZ52_RS13260	COG0714	Associated with various cellular activities
ESZ52_RS13280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ESZ52_RS13285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ESZ52_RS13285	COG0662	Cupin 2, conserved barrel domain protein
ESZ52_RS13290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ESZ52_RS13315	COG1079	Belongs to the binding-protein-dependent transport system permease family
ESZ52_RS13320	COG4603	Belongs to the binding-protein-dependent transport system permease family
ESZ52_RS13325	COG3845	ABC transporter
ESZ52_RS13330	COG1744	ABC transporter substrate-binding protein PnrA-like
ESZ52_RS13335	COG1473	amidohydrolase
ESZ52_RS13335	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ESZ52_RS13340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS13340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS13345	COG0167	dihydroorotate dehydrogenase activity
ESZ52_RS13355	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS13370	COG0039	L-malate dehydrogenase activity
ESZ52_RS13380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ESZ52_RS13390	COG0138	bifunctional purine biosynthesis protein purh
ESZ52_RS13415	COG0045	succinate-CoA ligase (ADP-forming) activity
ESZ52_RS13420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS13420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS13455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ESZ52_RS13455	COG0519	Catalyzes the synthesis of GMP from XMP
ESZ52_RS13475	COG0516	GMP reductase activity
ESZ52_RS13490	COG0459	protein refolding
ESZ52_RS13495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ESZ52_RS13510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ESZ52_RS13515	COG1214	PFAM Peptidase M22, glycoprotease
ESZ52_RS13515	COG0456	acetyltransferase
ESZ52_RS13520	COG1214	PFAM Peptidase M22, glycoprotease
ESZ52_RS13520	COG0456	acetyltransferase
ESZ52_RS13540	COG1595	DNA-templated transcription, initiation
ESZ52_RS13560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ESZ52_RS13565	COG1162	GTPase activity
ESZ52_RS13570	COG0483	inositol monophosphate 1-phosphatase activity
ESZ52_RS13580	COG0612	Peptidase, M16
ESZ52_RS13590	COG1615	UPF0182 protein
ESZ52_RS13600	COG3480	Lon protease (S16) C-terminal proteolytic domain
ESZ52_RS13650	COG0210	DNA helicase
ESZ52_RS13660	COG1309	transcriptional regulator
ESZ52_RS13675	COG0513	Belongs to the DEAD box helicase family
ESZ52_RS13680	COG0613	PHP domain protein
ESZ52_RS13695	COG0006	proline dipeptidase activity
ESZ52_RS13705	COG2239	Acts as a magnesium transporter
ESZ52_RS13720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ESZ52_RS13725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESZ52_RS13730	COG1595	DNA-templated transcription, initiation
ESZ52_RS13735	COG4122	O-methyltransferase activity
ESZ52_RS13750	COG1024	Enoyl-CoA hydratase
ESZ52_RS13760	COG0519	Catalyzes the synthesis of GMP from XMP
ESZ52_RS13770	COG1611	Belongs to the LOG family
ESZ52_RS13800	COG1217	gtp-binding protein TYPA
ESZ52_RS13810	COG0747	negative chemotaxis
ESZ52_RS13815	COG0601	transmembrane transport
ESZ52_RS13820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESZ52_RS13825	COG0444	Belongs to the ABC transporter superfamily
ESZ52_RS13830	COG4608	Belongs to the ABC transporter superfamily
ESZ52_RS13850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ESZ52_RS13875	COG1131	(ABC) transporter
ESZ52_RS13910	COG1621	beta-fructofuranosidase activity
ESZ52_RS13915	COG0154	amidase activity
ESZ52_RS13930	COG0697	spore germination
ESZ52_RS13950	COG1228	amidohydrolase
ESZ52_RS13965	COG0154	amidase activity
ESZ52_RS13975	COG1802	Transcriptional regulator
ESZ52_RS13980	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESZ52_RS13990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESZ52_RS13990	COG1116	anion transmembrane transporter activity
ESZ52_RS14015	COG0386	Belongs to the glutathione peroxidase family
ESZ52_RS14035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ESZ52_RS14060	COG3467	pyridoxamine 5'-phosphate
ESZ52_RS14065	COG0488	(ABC) transporter
ESZ52_RS14110	COG1917	Cupin 2, conserved barrel domain protein
ESZ52_RS14110	COG2169	Transcriptional regulator
ESZ52_RS14130	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESZ52_RS14140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ESZ52_RS14150	COG1309	transcriptional regulator
ESZ52_RS14155	COG1131	(ABC) transporter
ESZ52_RS14160	COG3559	Exporter of polyketide antibiotics
ESZ52_RS14175	COG0589	response to stress
ESZ52_RS14180	COG2838	Isocitrate dehydrogenase
ESZ52_RS14200	COG0012	GTP binding
ESZ52_RS14205	COG1024	Enoyl-CoA hydratase
ESZ52_RS14210	COG2267	carboxylic ester hydrolase activity
ESZ52_RS14215	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS14225	COG0318	PFAM AMP-dependent synthetase and ligase
ESZ52_RS14245	COG0411	ABC transporter
ESZ52_RS14255	COG1322	Protein conserved in bacteria
ESZ52_RS14260	COG1126	abc transporter atp-binding protein
ESZ52_RS14265	COG0765	amino acid transport
ESZ52_RS14275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ESZ52_RS14285	COG1570	exodeoxyribonuclease VII activity
ESZ52_RS14300	COG1722	exodeoxyribonuclease VII activity
ESZ52_RS14330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESZ52_RS14335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ESZ52_RS14340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ESZ52_RS14355	COG0205	6-phosphofructokinase activity
ESZ52_RS14375	COG0604	alcohol dehydrogenase
ESZ52_RS14380	COG0101	tRNA pseudouridine synthase activity
ESZ52_RS14400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ESZ52_RS14405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ESZ52_RS14410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ESZ52_RS14415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ESZ52_RS14430	COG0563	adenylate kinase activity
ESZ52_RS14440	COG0200	Binds to the 23S rRNA
ESZ52_RS14445	COG1841	ribosomal large subunit assembly
ESZ52_RS14450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ESZ52_RS14455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ESZ52_RS14460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ESZ52_RS14465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ESZ52_RS14475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ESZ52_RS14480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ESZ52_RS14485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ESZ52_RS14490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ESZ52_RS14495	COG0255	Belongs to the universal ribosomal protein uL29 family
ESZ52_RS14500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ESZ52_RS14505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ESZ52_RS14510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ESZ52_RS14515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ESZ52_RS14520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ESZ52_RS14525	COG0089	rRNA binding
ESZ52_RS14530	COG0088	Forms part of the polypeptide exit tunnel
ESZ52_RS14535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ESZ52_RS14540	COG0051	transcription antitermination factor activity, RNA binding
ESZ52_RS14555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ESZ52_RS14560	COG0049	tRNA binding
ESZ52_RS14565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ESZ52_RS14570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ESZ52_RS14575	COG0085	RNA polymerase activity
ESZ52_RS14580	COG0222	ribosome binding
ESZ52_RS14585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ESZ52_RS14600	COG0081	regulation of translation
ESZ52_RS14605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ESZ52_RS14625	COG0436	Aminotransferase
ESZ52_RS14640	COG1131	(ABC) transporter
ESZ52_RS14660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ESZ52_RS14665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ESZ52_RS14675	COG2030	dehydratase
ESZ52_RS14680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESZ52_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS14730	COG0657	acetylesterase activity
ESZ52_RS14735	COG2072	flavoprotein involved in K transport
ESZ52_RS14740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ESZ52_RS14760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ESZ52_RS14765	COG0477	Major facilitator Superfamily
ESZ52_RS14770	COG1666	GTP binding
ESZ52_RS14780	COG2323	membrane
ESZ52_RS14795	COG0501	Belongs to the peptidase M48B family
ESZ52_RS14800	COG1007	ATP synthesis coupled electron transport
ESZ52_RS14805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESZ52_RS14815	COG0713	ATP synthesis coupled electron transport
ESZ52_RS14830	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ESZ52_RS14850	COG1295	ribonuclease BN
ESZ52_RS14860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESZ52_RS14865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESZ52_RS14895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ESZ52_RS14900	COG0189	ligase activity
ESZ52_RS14910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ESZ52_RS14920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ESZ52_RS14925	COG0674	pyruvate-flavodoxin oxidoreductase activity
ESZ52_RS14925	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ESZ52_RS14930	COG1013	pyruvate-flavodoxin oxidoreductase activity
ESZ52_RS14945	COG2409	Drug exporters of the RND superfamily
ESZ52_RS14975	COG0142	geranyltranstransferase activity
ESZ52_RS14980	COG1007	ATP synthesis coupled electron transport
ESZ52_RS15005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ESZ52_RS15005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESZ52_RS15010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ESZ52_RS15015	COG1034	ATP synthesis coupled electron transport
ESZ52_RS15020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ESZ52_RS15030	COG0649	NAD binding
ESZ52_RS15035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESZ52_RS15060	COG0517	IMP dehydrogenase activity
ESZ52_RS15060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ESZ52_RS15065	COG2226	methyltransferase
ESZ52_RS15070	COG1169	isochorismate synthase
ESZ52_RS15080	COG0738	Major facilitator superfamily
ESZ52_RS15085	COG4552	Acetyltransferase involved in intracellular survival and related
ESZ52_RS15090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ESZ52_RS15095	COG1070	Carbohydrate kinase
ESZ52_RS15110	COG3590	peptidase
ESZ52_RS15120	COG3559	Exporter of polyketide antibiotics
ESZ52_RS15130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS15135	COG4166	transmembrane transport
ESZ52_RS15140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESZ52_RS15150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ESZ52_RS15155	COG1051	belongs to the nudix hydrolase family
ESZ52_RS15160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ESZ52_RS15165	COG1554	hydrolase, family 65, central catalytic
ESZ52_RS15170	COG1061	Type III restriction enzyme res subunit
ESZ52_RS15175	COG0546	phosphoglycolate phosphatase activity
ESZ52_RS15180	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS15185	COG2205	protein histidine kinase activity
ESZ52_RS15195	COG1126	abc transporter atp-binding protein
ESZ52_RS15200	COG0765	amino acid transport
ESZ52_RS15205	COG0765	amino acid transport
ESZ52_RS15215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESZ52_RS15235	COG3973	AAA domain
ESZ52_RS15235	COG3973	AAA domain
ESZ52_RS15240	COG0463	Glycosyl transferase, family 2
ESZ52_RS15265	COG1051	belongs to the nudix hydrolase family
ESZ52_RS15275	COG0459	protein refolding
ESZ52_RS15295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ESZ52_RS15315	COG0725	ABC transporter, periplasmic molybdate-binding protein
ESZ52_RS15330	COG1960	acyl-CoA dehydrogenase activity
ESZ52_RS15365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS15370	COG3415	Transposase
ESZ52_RS15370	COG2801	Transposase and inactivated derivatives
ESZ52_RS15380	COG2031	fatty acid transporter
ESZ52_RS15385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESZ52_RS15400	COG0183	Belongs to the thiolase family
ESZ52_RS15410	COG2814	Major facilitator Superfamily
ESZ52_RS15480	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ESZ52_RS15495	COG3833	ABC-type maltose transport systems, permease component
ESZ52_RS15500	COG1175	transmembrane transport
ESZ52_RS15510	COG3842	ATPase activity
ESZ52_RS15530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESZ52_RS15535	COG0215	cysteine-tRNA ligase activity
ESZ52_RS15560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESZ52_RS15575	COG0318	PFAM AMP-dependent synthetase and ligase
ESZ52_RS15580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ESZ52_RS15585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ESZ52_RS15610	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS15615	COG0588	phosphoglycerate mutase activity
ESZ52_RS15625	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS15645	COG1490	D-aminoacyl-tRNA deacylase activity
ESZ52_RS15655	COG3246	L-lysine catabolic process to acetate
ESZ52_RS15660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ESZ52_RS15665	COG1316	TRANSCRIPTIONal
ESZ52_RS15675	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ESZ52_RS15685	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS15690	COG0456	acetyltransferase
ESZ52_RS15695	COG0406	alpha-ribazole phosphatase activity
ESZ52_RS15695	COG0494	nUDIX hydrolase
ESZ52_RS15740	COG2801	Transposase and inactivated derivatives
ESZ52_RS15765	COG4176	ABC-type proline glycine betaine transport system permease component
ESZ52_RS15795	COG0471	metal ion transport
ESZ52_RS15805	COG0582	viral genome integration into host DNA
ESZ52_RS15815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESZ52_RS15820	COG1492	cobalamin metabolic process
ESZ52_RS15840	COG4139	cobalamin transport
ESZ52_RS15845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ESZ52_RS15945	COG2130	NADP-dependent
ESZ52_RS16010	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS16035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ESZ52_RS16035	COG0512	Glutamine amidotransferase of anthranilate synthase
ESZ52_RS16045	COG1252	NADH dehydrogenase
ESZ52_RS16055	COG1796	DNA polymerase
ESZ52_RS16055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ESZ52_RS16080	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ESZ52_RS16100	COG0129	dihydroxy-acid dehydratase activity
ESZ52_RS16105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ESZ52_RS16110	COG0440	acetolactate synthase activity
ESZ52_RS16120	COG1695	Transcriptional regulator
ESZ52_RS16125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESZ52_RS16155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESZ52_RS16165	COG2873	o-acetylhomoserine
ESZ52_RS16170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ESZ52_RS16190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS16200	COG1739	Uncharacterized protein family UPF0029
ESZ52_RS16205	COG2372	response to copper ion
ESZ52_RS16220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ESZ52_RS16275	COG0433	COG0433 Predicted ATPase
ESZ52_RS16310	COG0590	tRNA wobble adenosine to inosine editing
ESZ52_RS16315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ESZ52_RS16320	COG0436	Aminotransferase
ESZ52_RS16330	COG0242	peptide deformylase activity
ESZ52_RS16335	COG0436	Aminotransferase
ESZ52_RS16350	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ESZ52_RS16365	COG1316	TRANSCRIPTIONal
ESZ52_RS16370	COG1278	Cold shock
ESZ52_RS16385	COG1045	serine acetyltransferase
ESZ52_RS16400	COG1876	peptidase activity
ESZ52_RS16405	COG0717	Belongs to the dCTP deaminase family
ESZ52_RS16415	COG1324	tolerance protein
ESZ52_RS16420	COG0318	PFAM AMP-dependent synthetase and ligase
ESZ52_RS16435	COG0546	phosphoglycolate phosphatase activity
ESZ52_RS16460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ESZ52_RS16475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESZ52_RS16480	COG0596	Alpha beta hydrolase
ESZ52_RS16505	COG3191	aminopeptidase activity
ESZ52_RS16525	COG4608	Belongs to the ABC transporter superfamily
ESZ52_RS16555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESZ52_RS16565	COG0747	negative chemotaxis
ESZ52_RS16570	COG1960	acyl-CoA dehydrogenase activity
ESZ52_RS16585	COG3336	cytochrome c oxidase
ESZ52_RS16600	COG1752	Esterase of the alpha-beta hydrolase superfamily
ESZ52_RS16610	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESZ52_RS16615	COG0022	dehydrogenase e1 component
ESZ52_RS16665	COG1404	Belongs to the peptidase S8 family
ESZ52_RS16680	COG1950	PFAM Membrane protein of
ESZ52_RS16685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ESZ52_RS16700	COG0351	phosphomethylpyrimidine kinase
ESZ52_RS16720	COG2247	cell wall binding repeat
ESZ52_RS16720	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESZ52_RS16735	COG1132	(ABC) transporter
ESZ52_RS16740	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS16750	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS16760	COG0745	RESPONSE REGULATOR receiver
ESZ52_RS16765	COG2205	protein histidine kinase activity
ESZ52_RS16785	COG3842	ATPase activity
ESZ52_RS16790	COG1176	ABC-type spermidine putrescine transport system, permease component I
ESZ52_RS16800	COG1126	abc transporter atp-binding protein
ESZ52_RS16805	COG0765	amino acid transport
ESZ52_RS16815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ESZ52_RS16840	COG0174	glutamine synthetase
ESZ52_RS16850	COG1473	amidohydrolase
ESZ52_RS16870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ESZ52_RS16890	COG1024	Enoyl-CoA hydratase
ESZ52_RS16895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ESZ52_RS16900	COG4221	oxidoreductase activity
ESZ52_RS16910	COG1129	ABC transporter
ESZ52_RS16920	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESZ52_RS16925	COG0673	inositol 2-dehydrogenase activity
ESZ52_RS16955	COG2801	Transposase and inactivated derivatives
ESZ52_RS16970	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS17000	COG1414	Transcriptional regulator
ESZ52_RS17020	COG4279	zinc finger
ESZ52_RS17025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESZ52_RS17030	COG2337	Toxic component of a toxin-antitoxin (TA) module
ESZ52_RS17065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ESZ52_RS17075	COG2186	Transcriptional regulator
ESZ52_RS17130	COG1086	Polysaccharide biosynthesis protein
ESZ52_RS17135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESZ52_RS17165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ESZ52_RS17185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESZ52_RS17190	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS17195	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS17205	COG1134	teichoic acid transport
ESZ52_RS17210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ESZ52_RS17235	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ESZ52_RS17290	COG1053	succinate dehydrogenase
ESZ52_RS17330	COG0579	oxidoreductase
ESZ52_RS17340	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ESZ52_RS17360	COG1215	transferase activity, transferring glycosyl groups
ESZ52_RS17375	COG1442	glycosyl transferase family 8
ESZ52_RS17375	COG1216	Glycosyl transferase, family 2
ESZ52_RS17390	COG0110	maltose O-acetyltransferase activity
ESZ52_RS17400	COG0438	transferase activity, transferring glycosyl groups
ESZ52_RS17410	COG2755	lipolytic protein G-D-S-L family
ESZ52_RS17410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ESZ52_RS17455	COG2197	response regulator
ESZ52_RS17460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ESZ52_RS17465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ESZ52_RS17470	COG2171	N-acyltransferase activity
ESZ52_RS17475	COG0436	Aminotransferase
ESZ52_RS17495	COG1088	dTDP-glucose 4,6-dehydratase activity
ESZ52_RS17505	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ESZ52_RS17510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ESZ52_RS17520	COG0673	inositol 2-dehydrogenase activity
ESZ52_RS17560	COG0489	protein tyrosine kinase activity
ESZ52_RS17560	COG3206	protein involved in exopolysaccharide biosynthesis
ESZ52_RS17605	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESZ52_RS17630	COG1074	ATP-dependent DNA helicase activity
ESZ52_RS17635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESZ52_RS17640	COG4591	ABC-type transport system involved in lipoprotein release permease component
ESZ52_RS17645	COG0577	efflux transmembrane transporter activity
ESZ52_RS17645	COG1136	(ABC) transporter
ESZ52_RS17655	COG2076	Multidrug Resistance protein
ESZ52_RS17660	COG2197	response regulator
ESZ52_RS17665	COG4585	Histidine kinase
ESZ52_RS17670	COG0442	prolyl-tRNA aminoacylation
ESZ52_RS17675	COG2072	flavoprotein involved in K transport
ESZ52_RS17680	COG2610	gluconate transmembrane transporter activity
ESZ52_RS17685	COG3265	gluconokinase activity
ESZ52_RS17700	COG0058	SHG alpha-glucan phosphorylase activity
ESZ52_RS17730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ESZ52_RS17745	COG3573	Dehydrogenase
ESZ52_RS17760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ESZ52_RS17760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ESZ52_RS17795	COG1404	Belongs to the peptidase S8 family
ESZ52_RS17800	COG0339	signal peptide processing
ESZ52_RS17815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ESZ52_RS17820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ESZ52_RS17825	COG0586	Pfam SNARE associated Golgi protein
ESZ52_RS17845	COG1268	BioY protein
ESZ52_RS17870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESZ52_RS17875	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESZ52_RS17880	COG1120	ATPase activity
ESZ52_RS17885	COG2409	Drug exporters of the RND superfamily
ESZ52_RS17895	COG0315	cyclic pyranopterin monophosphate synthase activity
ESZ52_RS17895	COG0521	Mo-molybdopterin cofactor biosynthetic process
ESZ52_RS17900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ESZ52_RS17910	COG0746	molybdenum cofactor guanylyltransferase activity
ESZ52_RS17930	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ESZ52_RS17935	COG1140	nitrate reductase beta subunit
ESZ52_RS17975	COG2132	Multicopper oxidase
ESZ52_RS17985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ESZ52_RS17990	COG2814	Major facilitator Superfamily
ESZ52_RS17995	COG2149	membrane
ESZ52_RS18010	COG1846	Transcriptional regulator
ESZ52_RS18025	COG0709	Synthesizes selenophosphate from selenide and ATP
ESZ52_RS18040	COG0437	4 iron, 4 sulfur cluster binding
ESZ52_RS18070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESZ52_RS18075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESZ52_RS18085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESZ52_RS18100	COG3275	phosphorelay sensor kinase activity
ESZ52_RS18105	COG0477	Major facilitator Superfamily
ESZ52_RS18115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ESZ52_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS18135	COG0667	Aldo Keto reductase
ESZ52_RS18160	COG0183	Belongs to the thiolase family
ESZ52_RS18165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS18165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESZ52_RS18170	COG0318	PFAM AMP-dependent synthetase and ligase
ESZ52_RS18220	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESZ52_RS18240	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS18245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ESZ52_RS18255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ESZ52_RS18265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESZ52_RS18270	COG1404	Belongs to the peptidase S8 family
ESZ52_RS18270	COG4412	M6 family metalloprotease domain protein
ESZ52_RS18290	COG1266	CAAX protease self-immunity
ESZ52_RS18300	COG0300	oxidoreductase activity
ESZ52_RS18310	COG1230	cation diffusion facilitator family transporter
ESZ52_RS18340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ESZ52_RS18345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ESZ52_RS18350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESZ52_RS18355	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ESZ52_RS18375	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ESZ52_RS18385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ESZ52_RS18390	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ESZ52_RS18400	COG0189	ligase activity
ESZ52_RS18400	COG4067	protein conserved in archaea
ESZ52_RS18405	COG0189	ligase activity
ESZ52_RS18405	COG0569	domain protein
ESZ52_RS18430	COG0657	acetylesterase activity
ESZ52_RS18440	COG2226	methyltransferase
ESZ52_RS18455	COG1476	TRANSCRIPTIONal
ESZ52_RS18500	COG1929	Belongs to the glycerate kinase type-1 family
ESZ52_RS18505	COG2252	PERMEase
ESZ52_RS18515	COG1819	glycosyl
ESZ52_RS18540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESZ52_RS18570	COG1028	Short-chain dehydrogenase reductase Sdr
ESZ52_RS18580	COG4585	Histidine kinase
ESZ52_RS18605	COG2217	Heavy metal translocating P-type atpase
ESZ52_RS18635	COG2226	methyltransferase
ESZ52_RS18645	COG0662	Cupin 2, conserved barrel domain protein
ESZ52_RS18700	COG0456	acetyltransferase
ESZ52_RS18745	COG1714	RDD family
ESZ52_RS18755	COG0656	L-ascorbic acid biosynthetic process
ESZ52_RS18775	COG1320	monovalent cation:proton antiporter activity
ESZ52_RS18780	COG2212	antiporter activity
ESZ52_RS18790	COG0651	ATP synthesis coupled electron transport
ESZ52_RS18795	COG1006	Multisubunit Na H antiporter MnhC subunit
ESZ52_RS18800	COG2111	Na H antiporter
ESZ52_RS18800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ESZ52_RS18805	COG0359	binds to the 23S rRNA
ESZ52_RS18810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ESZ52_RS18820	COG0360	Binds together with S18 to 16S ribosomal RNA
ESZ52_RS18865	COG1134	teichoic acid transport
ESZ52_RS18930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESZ52_RS18950	COG0617	tRNA 3'-terminal CCA addition
ESZ52_RS18970	COG1595	DNA-templated transcription, initiation
ESZ52_RS18980	COG0492	ferredoxin-NADP+ reductase activity
ESZ52_RS18985	COG3118	belongs to the thioredoxin family
ESZ52_RS18995	COG1192	Involved in chromosome partitioning
ESZ52_RS19000	COG0357	Ribosomal RNA small subunit methyltransferase G
ESZ52_RS19010	COG0706	membrane insertase activity
ESZ52_RS19015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ESZ52_RS19025	COG0230	Belongs to the bacterial ribosomal protein bL34 family