locus-tag	class	description
FY030_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY030_RS00010	COG0592	DNA-directed DNA polymerase activity
FY030_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FY030_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY030_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FY030_RS00030	COG0187	DNA topoisomerase II activity
FY030_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY030_RS00040	COG3266	domain, Protein
FY030_RS00045	COG1476	TRANSCRIPTIONal
FY030_RS00055	COG1131	(ABC) transporter
FY030_RS00075	COG1396	sequence-specific DNA binding
FY030_RS00110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY030_RS00125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY030_RS00175	COG2197	response regulator
FY030_RS00180	COG4585	Histidine kinase
FY030_RS00200	COG1309	transcriptional regulator
FY030_RS00220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FY030_RS00240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FY030_RS00245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY030_RS00245	COG2755	lipolytic protein G-D-S-L family
FY030_RS00275	COG0515	serine threonine protein kinase
FY030_RS00280	COG0768	penicillin binding
FY030_RS00295	COG1716	ATPase activity
FY030_RS00340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FY030_RS00370	COG1233	COG1233 Phytoene dehydrogenase and related
FY030_RS00375	COG4106	trans-aconitate 2-methyltransferase activity
FY030_RS00380	COG1131	(ABC) transporter
FY030_RS00400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FY030_RS00420	COG1404	Belongs to the peptidase S8 family
FY030_RS00435	COG1966	Carbon starvation protein
FY030_RS00445	COG2197	response regulator
FY030_RS00450	COG4585	Histidine kinase
FY030_RS00455	COG1793	dna ligase
FY030_RS00470	COG0702	epimerase
FY030_RS00505	COG0438	transferase activity, transferring glycosyl groups
FY030_RS00540	COG1174	glycine betaine transport
FY030_RS00545	COG1174	glycine betaine transport
FY030_RS00560	COG4085	toxin activity
FY030_RS00560	COG1525	nuclease
FY030_RS00560	COG0737	Belongs to the 5'-nucleotidase family
FY030_RS00570	COG0860	N-Acetylmuramoyl-L-alanine amidase
FY030_RS00570	COG2247	cell wall binding repeat
FY030_RS00610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY030_RS00625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY030_RS00690	COG1674	ftsk spoiiie
FY030_RS00740	COG0415	Belongs to the DNA photolyase family
FY030_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS00800	COG1175	transmembrane transport
FY030_RS00805	COG0395	ABC-type sugar transport system, permease component
FY030_RS00825	COG0471	metal ion transport
FY030_RS00830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY030_RS00850	COG1215	transferase activity, transferring glycosyl groups
FY030_RS00865	COG1597	lipid kinase activity
FY030_RS00870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY030_RS00895	COG4585	Histidine kinase
FY030_RS00900	COG2197	response regulator
FY030_RS00905	COG4152	abc transporter atp-binding protein
FY030_RS00915	COG0561	phosphatase activity
FY030_RS00920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY030_RS00930	COG2217	Heavy metal translocating P-type atpase
FY030_RS00940	COG1937	Protein conserved in bacteria
FY030_RS00965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY030_RS00980	COG1136	(ABC) transporter
FY030_RS00985	COG1136	(ABC) transporter
FY030_RS01005	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY030_RS01020	COG0813	purine-nucleoside phosphorylase activity
FY030_RS01035	COG2133	pyrroloquinoline quinone binding
FY030_RS01050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FY030_RS01080	COG3655	Transcriptional regulator
FY030_RS01085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY030_RS01095	COG1131	(ABC) transporter
FY030_RS01175	COG0300	oxidoreductase activity
FY030_RS01185	COG0443	Heat shock 70 kDa protein
FY030_RS01190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FY030_RS01195	COG0484	heat shock protein binding
FY030_RS01200	COG0789	Transcriptional regulator
FY030_RS01220	COG2197	response regulator
FY030_RS01235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FY030_RS01265	COG3025	triphosphatase activity
FY030_RS01265	COG5607	PFAM CHAD domain containing protein
FY030_RS01275	COG0428	transporter
FY030_RS01280	COG0542	response to heat
FY030_RS01300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY030_RS01325	COG0708	Exodeoxyribonuclease III
FY030_RS01340	COG4221	oxidoreductase activity
FY030_RS01345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY030_RS01375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FY030_RS01405	COG2326	polyphosphate kinase activity
FY030_RS01410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY030_RS01410	COG0047	phosphoribosylformylglycinamidine synthase activity
FY030_RS01415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY030_RS01420	COG0151	Belongs to the GarS family
FY030_RS01450	COG0204	Acyl-transferase
FY030_RS01450	COG0318	PFAM AMP-dependent synthetase and ligase
FY030_RS01455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FY030_RS01480	COG1863	multisubunit Na H antiporter MnhE subunit
FY030_RS01495	COG2111	Na H antiporter
FY030_RS01495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY030_RS01500	COG1760	l-serine dehydratase
FY030_RS01515	COG1280	lysine exporter protein (LysE YggA)
FY030_RS01525	COG1408	metallophosphoesterase
FY030_RS01530	COG1610	YqeY-like protein
FY030_RS01535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY030_RS01560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY030_RS01585	COG0494	nUDIX hydrolase
FY030_RS01630	COG1205	dead DEAH box helicase
FY030_RS01630	COG1111	helicase
FY030_RS01635	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FY030_RS01645	COG2890	protein-(glutamine-N5) methyltransferase activity
FY030_RS01655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY030_RS01655	COG1754	DNA topoisomerase type I activity
FY030_RS01660	COG0626	cystathionine gamma-synthase activity
FY030_RS01670	COG1404	Belongs to the peptidase S8 family
FY030_RS01670	COG4412	M6 family metalloprotease domain protein
FY030_RS01680	COG0789	Transcriptional regulator
FY030_RS01685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY030_RS01690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY030_RS01710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FY030_RS01725	COG0037	tRNA processing
FY030_RS01740	COG0302	gtp cyclohydrolase
FY030_RS01745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FY030_RS01750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FY030_RS01770	COG0649	NAD binding
FY030_RS01780	COG0530	calcium, potassium:sodium antiporter activity
FY030_RS01795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY030_RS01810	COG3285	dna ligase
FY030_RS01810	COG1793	dna ligase
FY030_RS01820	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY030_RS01825	COG0542	response to heat
FY030_RS01840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FY030_RS01855	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FY030_RS01870	COG0248	Ppx GppA phosphatase
FY030_RS01875	COG1082	Xylose isomerase domain protein TIM barrel
FY030_RS01880	COG0506	proline dehydrogenase activity
FY030_RS01885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FY030_RS01895	COG0123	including yeast histone deacetylase and acetoin utilization protein
FY030_RS01915	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FY030_RS01920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FY030_RS01925	COG0181	hydroxymethylbilane synthase activity
FY030_RS01935	COG0113	porphobilinogen synthase activity
FY030_RS01945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FY030_RS01950	COG0406	alpha-ribazole phosphatase activity
FY030_RS01960	COG0785	Cytochrome C biogenesis protein
FY030_RS01970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY030_RS02020	COG4948	Mandelate Racemase Muconate Lactonizing
FY030_RS02030	COG1278	Cold shock
FY030_RS02065	COG0259	pyridoxamine-phosphate oxidase activity
FY030_RS02070	COG1321	iron dependent repressor
FY030_RS02075	COG1388	LysM domain
FY030_RS02075	COG3103	Sh3 type 3 domain protein
FY030_RS02075	COG0791	NLP P60 protein
FY030_RS02090	COG0420	3'-5' exonuclease activity
FY030_RS02120	COG4974	Belongs to the 'phage' integrase family
FY030_RS02130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY030_RS02245	COG0477	Major facilitator Superfamily
FY030_RS02260	COG1970	mechanosensitive ion channel activity
FY030_RS02290	COG0315	cyclic pyranopterin monophosphate synthase activity
FY030_RS02310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY030_RS02340	COG1053	succinate dehydrogenase
FY030_RS02345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FY030_RS02365	COG1595	DNA-templated transcription, initiation
FY030_RS02400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY030_RS02405	COG0084	hydrolase, TatD family'
FY030_RS02420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY030_RS02430	COG0488	(ABC) transporter
FY030_RS02450	COG1309	transcriptional regulator
FY030_RS02455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY030_RS02460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY030_RS02465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FY030_RS02470	COG0193	aminoacyl-tRNA hydrolase activity
FY030_RS02475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY030_RS02480	COG2011	ABC-type metal ion transport system permease component
FY030_RS02490	COG1464	Belongs to the NlpA lipoprotein family
FY030_RS02505	COG1842	Phage shock protein A
FY030_RS02535	COG0148	phosphopyruvate hydratase activity
FY030_RS02585	COG0789	Transcriptional regulator
FY030_RS02610	COG2354	Protein conserved in bacteria
FY030_RS02615	COG0183	Belongs to the thiolase family
FY030_RS02620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY030_RS02625	COG0318	PFAM AMP-dependent synthetase and ligase
FY030_RS02630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY030_RS02640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY030_RS02650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY030_RS02660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY030_RS02675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY030_RS02680	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FY030_RS02690	COG1072	(Pantothenic acid kinase))
FY030_RS02700	COG0736	holo-[acyl-carrier-protein] synthase activity
FY030_RS02715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY030_RS02730	COG0549	Belongs to the carbamate kinase family
FY030_RS02740	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
FY030_RS02770	COG2233	PERMEase
FY030_RS02790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FY030_RS02795	COG1304	FMN binding
FY030_RS02805	COG0154	amidase activity
FY030_RS02815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY030_RS02820	COG0066	3-isopropylmalate dehydratase activity
FY030_RS02825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FY030_RS02830	COG0473	3-isopropylmalate dehydrogenase activity
FY030_RS02835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY030_RS02840	COG0802	atpase or kinase
FY030_RS02950	COG0018	arginyl-trna synthetase
FY030_RS02955	COG0460	homoserine dehydrogenase
FY030_RS02965	COG0254	rRNA binding
FY030_RS02970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FY030_RS02975	COG2890	protein-(glutamine-N5) methyltransferase activity
FY030_RS02980	COG2755	lipolytic protein G-D-S-L family
FY030_RS02980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY030_RS02985	COG0009	L-threonylcarbamoyladenylate synthase
FY030_RS02990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY030_RS02995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY030_RS03010	COG0356	it plays a direct role in the translocation of protons across the membrane
FY030_RS03015	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY030_RS03020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY030_RS03025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY030_RS03030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY030_RS03035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY030_RS03040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY030_RS03045	COG0427	acetyl-CoA hydrolase
FY030_RS03050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY030_RS03075	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FY030_RS03080	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY030_RS03100	COG0183	Belongs to the thiolase family
FY030_RS03130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FY030_RS03135	COG0366	Alpha amylase catalytic
FY030_RS03140	COG0366	Alpha amylase catalytic
FY030_RS03155	COG1024	Enoyl-CoA hydratase
FY030_RS03180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FY030_RS03190	COG0482	sulfurtransferase activity
FY030_RS03205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY030_RS03220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY030_RS03225	COG0154	amidase activity
FY030_RS03230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY030_RS03265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY030_RS03270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY030_RS03280	COG1473	amidohydrolase
FY030_RS03285	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY030_RS03290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FY030_RS03300	COG1234	tRNA 3'-trailer cleavage
FY030_RS03310	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY030_RS03320	COG2364	Membrane
FY030_RS03340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FY030_RS03345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY030_RS03355	COG0083	homoserine kinase activity
FY030_RS03360	COG0384	phenazine biosynthesis protein PhzF
FY030_RS03390	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY030_RS03395	COG0156	8-amino-7-oxononanoate synthase activity
FY030_RS03400	COG1063	alcohol dehydrogenase
FY030_RS03405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY030_RS03415	COG1295	ribonuclease BN
FY030_RS03430	COG0247	lactate metabolic process
FY030_RS03430	COG0277	FAD linked oxidase domain protein
FY030_RS03435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FY030_RS03445	COG0372	Belongs to the citrate synthase family
FY030_RS03450	COG0372	Belongs to the citrate synthase family
FY030_RS03460	COG1414	Transcriptional regulator
FY030_RS03465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY030_RS03470	COG1414	Transcriptional regulator
FY030_RS03485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FY030_RS03505	COG0488	(ABC) transporter
FY030_RS03525	COG1309	transcriptional regulator
FY030_RS03530	COG1129	ABC transporter
FY030_RS03545	COG2267	carboxylic ester hydrolase activity
FY030_RS03560	COG1605	Chorismate mutase
FY030_RS03560	COG0287	Prephenate dehydrogenase
FY030_RS03595	COG0564	pseudouridine synthase activity
FY030_RS03605	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FY030_RS03605	COG1404	Belongs to the peptidase S8 family
FY030_RS03610	COG1946	Acyl-CoA thioesterase
FY030_RS03615	COG1556	Lactate utilization protein
FY030_RS03625	COG0247	lactate metabolic process
FY030_RS03645	COG1278	Cold shock
FY030_RS03660	COG0366	Alpha amylase catalytic
FY030_RS03665	COG2346	COG2346, Truncated hemoglobins
FY030_RS03675	COG0668	transmembrane transport
FY030_RS03690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FY030_RS03700	COG2239	Acts as a magnesium transporter
FY030_RS03720	COG0544	peptidyl-prolyl cis-trans isomerase activity
FY030_RS03730	COG0740	serine-type endopeptidase activity
FY030_RS03735	COG0740	serine-type endopeptidase activity
FY030_RS03745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY030_RS03775	COG0525	valine-tRNA ligase activity
FY030_RS03780	COG1115	amino acid carrier protein
FY030_RS03785	COG0277	FAD linked oxidase domain protein
FY030_RS03790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FY030_RS03800	COG0285	dihydrofolate synthase activity
FY030_RS03825	COG1968	undecaprenyl-diphosphatase activity
FY030_RS03830	COG0105	UTP biosynthetic process
FY030_RS03865	COG0768	penicillin binding
FY030_RS03870	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FY030_RS03895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY030_RS03900	COG1185	polyribonucleotide nucleotidyltransferase activity
FY030_RS03925	COG3396	Phenylacetate-CoA oxygenase
FY030_RS03930	COG3460	Phenylacetate-CoA oxygenase
FY030_RS03935	COG3396	Phenylacetate-CoA oxygenase
FY030_RS03940	COG2151	metal-sulfur cluster biosynthetic enzyme
FY030_RS03945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FY030_RS03950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY030_RS03955	COG0424	maF-like protein
FY030_RS03975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY030_RS03985	COG1024	Enoyl-CoA hydratase
FY030_RS03990	COG0745	RESPONSE REGULATOR receiver
FY030_RS04010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FY030_RS04015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS04030	COG0515	serine threonine protein kinase
FY030_RS04035	COG1316	TRANSCRIPTIONal
FY030_RS04105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY030_RS04110	COG2835	tetraacyldisaccharide 4'-kinase activity
FY030_RS04110	COG1663	tetraacyldisaccharide 4'-kinase activity
FY030_RS04120	COG3483	tryptophan 2,3-dioxygenase activity
FY030_RS04135	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FY030_RS04140	COG0745	RESPONSE REGULATOR receiver
FY030_RS04145	COG5002	protein histidine kinase activity
FY030_RS04160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FY030_RS04165	COG3214	Protein conserved in bacteria
FY030_RS04170	COG0653	protein targeting
FY030_RS04210	COG1012	belongs to the aldehyde dehydrogenase family
FY030_RS04220	COG2902	Dehydrogenase
FY030_RS04235	COG1228	amidohydrolase
FY030_RS04250	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FY030_RS04265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY030_RS04280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FY030_RS04290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FY030_RS04305	COG0798	PFAM Bile acid sodium symporter
FY030_RS04325	COG2226	methyltransferase
FY030_RS04345	COG0268	Binds directly to 16S ribosomal RNA
FY030_RS04350	COG0495	leucyl-tRNA aminoacylation
FY030_RS04355	COG1307	EDD domain protein, DegV family
FY030_RS04365	COG1555	photosystem II stabilization
FY030_RS04365	COG1596	polysaccharide export
FY030_RS04375	COG0583	DNA-binding transcription factor activity
FY030_RS04380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FY030_RS04395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FY030_RS04425	COG2226	methyltransferase
FY030_RS04440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS04470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FY030_RS04525	COG2031	fatty acid transporter
FY030_RS04535	COG1129	ABC transporter
FY030_RS04540	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY030_RS04560	COG0673	inositol 2-dehydrogenase activity
FY030_RS04575	COG0659	secondary active sulfate transmembrane transporter activity
FY030_RS04585	COG0723	plastoquinol--plastocyanin reductase activity
FY030_RS04620	COG1725	Transcriptional regulator
FY030_RS04690	COG0464	growth
FY030_RS04705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY030_RS04715	COG2733	membrane
FY030_RS04725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS04740	COG1131	(ABC) transporter
FY030_RS04765	COG1643	Atp-dependent helicase
FY030_RS04770	COG1228	amidohydrolase
FY030_RS04775	COG0402	S-adenosylhomocysteine deaminase activity
FY030_RS04790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY030_RS04795	COG2154	pterin-4-alpha-carbinolamine dehydratase
FY030_RS04800	COG0584	glycerophosphoryl diester phosphodiesterase
FY030_RS04805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FY030_RS04805	COG0237	dephospho-CoA kinase activity
FY030_RS04810	COG0823	Involved in the tonB-independent uptake of proteins
FY030_RS04810	COG1506	peptidase
FY030_RS04830	COG0589	response to stress
FY030_RS04835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY030_RS04860	COG0714	Associated with various cellular activities
FY030_RS04865	COG2001	Belongs to the MraZ family
FY030_RS04870	COG0275	rRNA processing
FY030_RS04880	COG0768	penicillin binding
FY030_RS04885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FY030_RS04890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY030_RS04895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY030_RS04905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY030_RS04910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FY030_RS04915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY030_RS04920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY030_RS04935	COG1799	cell septum assembly
FY030_RS04945	COG3599	regulation of cell shape
FY030_RS04950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FY030_RS04965	COG0587	DNA-directed DNA polymerase activity
FY030_RS04985	COG4166	transmembrane transport
FY030_RS04990	COG0601	transmembrane transport
FY030_RS05000	COG0444	Belongs to the ABC transporter superfamily
FY030_RS05005	COG4608	Belongs to the ABC transporter superfamily
FY030_RS05015	COG4129	membrane
FY030_RS05075	COG1595	DNA-templated transcription, initiation
FY030_RS05085	COG2197	response regulator
FY030_RS05090	COG4585	Histidine kinase
FY030_RS05100	COG1131	(ABC) transporter
FY030_RS05145	COG0589	response to stress
FY030_RS05185	COG0656	L-ascorbic acid biosynthetic process
FY030_RS05200	COG1131	(ABC) transporter
FY030_RS05210	COG1131	(ABC) transporter
FY030_RS05265	COG1404	Belongs to the peptidase S8 family
FY030_RS05310	COG0745	RESPONSE REGULATOR receiver
FY030_RS05315	COG2205	protein histidine kinase activity
FY030_RS05335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FY030_RS05345	COG0590	tRNA wobble adenosine to inosine editing
FY030_RS05345	COG0037	tRNA processing
FY030_RS05350	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FY030_RS05365	COG0321	lipoyl(octanoyl) transferase activity
FY030_RS05370	COG0515	serine threonine protein kinase
FY030_RS05370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY030_RS05380	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY030_RS05385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY030_RS05395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY030_RS05400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY030_RS05415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY030_RS05420	COG0435	Glutathione S-transferase
FY030_RS05425	COG0180	Tryptophanyl-tRNA synthetase
FY030_RS05440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FY030_RS05445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY030_RS05450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY030_RS05465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY030_RS05470	COG1845	cytochrome c oxidase, subunit III
FY030_RS05480	COG0723	plastoquinol--plastocyanin reductase activity
FY030_RS05485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FY030_RS05515	COG1940	carbohydrate kinase activity
FY030_RS05520	COG1940	carbohydrate kinase activity
FY030_RS05540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FY030_RS05550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY030_RS05555	COG0515	serine threonine protein kinase
FY030_RS05555	COG2815	serine threonine protein kinase
FY030_RS05560	COG2815	serine threonine protein kinase
FY030_RS05560	COG0515	serine threonine protein kinase
FY030_RS05565	COG1388	LysM domain
FY030_RS05565	COG3942	CHAP domain
FY030_RS05575	COG0142	geranyltranstransferase activity
FY030_RS05590	COG0587	DNA-directed DNA polymerase activity
FY030_RS05615	COG0187	DNA topoisomerase II activity
FY030_RS05620	COG0513	Belongs to the DEAD box helicase family
FY030_RS05625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FY030_RS05640	COG0733	neurotransmitter:sodium symporter activity
FY030_RS05645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY030_RS05685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY030_RS05685	COG1703	isobutyryl-CoA mutase activity
FY030_RS05685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY030_RS05695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FY030_RS05700	COG3268	Saccharopine dehydrogenase
FY030_RS05715	COG2755	lipolytic protein G-D-S-L family
FY030_RS05715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY030_RS05735	COG1012	belongs to the aldehyde dehydrogenase family
FY030_RS05770	COG3387	PFAM Glycoside hydrolase 15-related
FY030_RS05775	COG0513	Belongs to the DEAD box helicase family
FY030_RS05785	COG1802	Transcriptional regulator
FY030_RS05790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY030_RS05795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY030_RS05800	COG3493	citrate carrier protein
FY030_RS05820	COG1960	acyl-CoA dehydrogenase activity
FY030_RS05825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY030_RS05830	COG2855	membrane
FY030_RS05835	COG2855	membrane
FY030_RS05840	COG0588	phosphoglycerate mutase activity
FY030_RS05855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY030_RS05885	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS05895	COG0596	Alpha beta hydrolase
FY030_RS05900	COG0432	Pfam Uncharacterised protein family UPF0047
FY030_RS05925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY030_RS05965	COG1473	amidohydrolase
FY030_RS05980	COG0778	Nitroreductase
FY030_RS06005	COG1435	thymidine kinase activity
FY030_RS06035	COG0756	dUTP diphosphatase activity
FY030_RS06050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY030_RS06055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY030_RS06060	COG2514	catechol 2,3-dioxygenase activity
FY030_RS06065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS06095	COG2326	polyphosphate kinase activity
FY030_RS06130	COG1757	Na H antiporter
FY030_RS06140	COG0483	inositol monophosphate 1-phosphatase activity
FY030_RS06175	COG0351	phosphomethylpyrimidine kinase
FY030_RS06180	COG0352	thiamine-phosphate diphosphorylase activity
FY030_RS06185	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FY030_RS06200	COG1132	(ABC) transporter
FY030_RS06250	COG2267	carboxylic ester hydrolase activity
FY030_RS06265	COG0860	N-Acetylmuramoyl-L-alanine amidase
FY030_RS06265	COG2247	cell wall binding repeat
FY030_RS06290	COG0584	glycerophosphoryl diester phosphodiesterase
FY030_RS06300	COG4589	Belongs to the CDS family
FY030_RS06315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY030_RS06335	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FY030_RS06350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FY030_RS06370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY030_RS06375	COG3285	dna ligase
FY030_RS06375	COG1793	dna ligase
FY030_RS06380	COG1793	dna ligase
FY030_RS06390	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FY030_RS06395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FY030_RS06400	COG3639	organic phosphonate transmembrane transporter activity
FY030_RS06405	COG2326	polyphosphate kinase activity
FY030_RS06530	COG2195	Cleaves the N-terminal amino acid of tripeptides
FY030_RS06535	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FY030_RS06555	COG0596	Alpha beta hydrolase
FY030_RS06555	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY030_RS06580	COG1027	Aspartate ammonia-lyase
FY030_RS06585	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FY030_RS06595	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FY030_RS06610	COG4145	pantothenate transmembrane transporter activity
FY030_RS06640	COG3546	catalase activity
FY030_RS06655	COG1546	Belongs to the CinA family
FY030_RS06655	COG1058	Belongs to the CinA family
FY030_RS06660	COG1131	(ABC) transporter
FY030_RS06690	COG0860	N-Acetylmuramoyl-L-alanine amidase
FY030_RS06690	COG2247	cell wall binding repeat
FY030_RS06705	COG1070	Carbohydrate kinase
FY030_RS06710	COG2115	Belongs to the xylose isomerase family
FY030_RS06720	COG1175	transmembrane transport
FY030_RS06730	COG1472	Belongs to the glycosyl hydrolase 3 family
FY030_RS06745	COG2017	converts alpha-aldose to the beta-anomer
FY030_RS06765	COG4948	Mandelate Racemase Muconate Lactonizing
FY030_RS06770	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FY030_RS06775	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FY030_RS06775	COG2508	Transcriptional regulator
FY030_RS06785	COG4608	Belongs to the ABC transporter superfamily
FY030_RS06805	COG1984	allophanate hydrolase subunit 2
FY030_RS06815	COG1914	H( )-stimulated, divalent metal cation uptake system
FY030_RS06860	COG1183	phosphatidylcholine synthase activity
FY030_RS06865	COG0793	Belongs to the peptidase S41A family
FY030_RS06865	COG4946	Tricorn protease homolog
FY030_RS06895	COG1597	lipid kinase activity
FY030_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS06925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY030_RS06940	COG0318	PFAM AMP-dependent synthetase and ligase
FY030_RS06945	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY030_RS06985	COG2084	Dehydrogenase
FY030_RS07000	COG0247	lactate metabolic process
FY030_RS07000	COG0277	FAD linked oxidase domain protein
FY030_RS07005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FY030_RS07010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY030_RS07015	COG1024	Enoyl-CoA hydratase
FY030_RS07015	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY030_RS07045	COG0395	ABC-type sugar transport system, permease component
FY030_RS07055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY030_RS07060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY030_RS07070	COG0438	transferase activity, transferring glycosyl groups
FY030_RS07075	COG0438	transferase activity, transferring glycosyl groups
FY030_RS07090	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
FY030_RS07110	COG0683	leucine binding
FY030_RS07115	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY030_RS07120	COG0411	ABC transporter
FY030_RS07125	COG0410	ABC transporter
FY030_RS07135	COG0861	Integral membrane protein TerC family
FY030_RS07145	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FY030_RS07170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FY030_RS07200	COG2319	Wd-40 repeat
FY030_RS07200	COG4249	Peptidase C14 caspase catalytic subunit p20
FY030_RS07230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FY030_RS07235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FY030_RS07245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY030_RS07310	COG1329	Transcriptional regulator
FY030_RS07325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY030_RS07345	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FY030_RS07350	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FY030_RS07355	COG0217	transcriptional regulatory protein
FY030_RS07360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FY030_RS07365	COG0632	four-way junction helicase activity
FY030_RS07370	COG2255	four-way junction helicase activity
FY030_RS07380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FY030_RS07385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FY030_RS07390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY030_RS07395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FY030_RS07400	COG1362	aminopeptidase activity
FY030_RS07405	COG1196	nuclear chromosome segregation
FY030_RS07435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FY030_RS07445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY030_RS07450	COG0131	Imidazoleglycerol-phosphate dehydratase
FY030_RS07450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FY030_RS07455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FY030_RS07465	COG0107	imidazoleglycerol-phosphate synthase activity
FY030_RS07505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FY030_RS07520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY030_RS07535	COG1160	GTP binding
FY030_RS07565	COG0509	glycine decarboxylation via glycine cleavage system
FY030_RS07590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY030_RS07590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY030_RS07615	COG0596	Alpha beta hydrolase
FY030_RS07620	COG0009	L-threonylcarbamoyladenylate synthase
FY030_RS07630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FY030_RS07635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY030_RS07660	COG2985	domain, Protein
FY030_RS07660	COG0569	domain protein
FY030_RS07670	COG1063	alcohol dehydrogenase
FY030_RS07690	COG2267	carboxylic ester hydrolase activity
FY030_RS07695	COG2814	Major facilitator Superfamily
FY030_RS07720	COG1335	isochorismatase
FY030_RS07725	COG2814	Major facilitator Superfamily
FY030_RS07735	COG3609	addiction module antidote protein, CC2985 family
FY030_RS07740	COG2337	Toxic component of a toxin-antitoxin (TA) module
FY030_RS07745	COG2318	DinB family
FY030_RS07750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY030_RS07775	COG0686	Belongs to the AlaDH PNT family
FY030_RS07790	COG0537	adenosine 5'-monophosphoramidase activity
FY030_RS07815	COG0676	glucose-6-phosphate 1-epimerase activity
FY030_RS07840	COG0463	Glycosyl transferase, family 2
FY030_RS07850	COG1607	acyl-coa hydrolase
FY030_RS07855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY030_RS07860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY030_RS07875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FY030_RS07880	COG1619	proteins homologs of microcin C7 resistance protein MccF
FY030_RS07885	COG1522	sequence-specific DNA binding
FY030_RS07895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY030_RS07910	COG4581	dead DEAH box helicase
FY030_RS07920	COG0805	protein transport
FY030_RS07925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY030_RS07930	COG2378	regulation of single-species biofilm formation
FY030_RS07945	COG2066	Belongs to the glutaminase family
FY030_RS07960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FY030_RS07975	COG1309	transcriptional regulator
FY030_RS07980	COG0477	Major facilitator Superfamily
FY030_RS07990	COG1222	aaa ATPase
FY030_RS08010	COG0517	IMP dehydrogenase activity
FY030_RS08010	COG1994	Peptidase M50
FY030_RS08025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY030_RS08030	COG0215	cysteine-tRNA ligase activity
FY030_RS08070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY030_RS08140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY030_RS08150	COG1725	Transcriptional regulator
FY030_RS08170	COG2755	lipolytic protein G-D-S-L family
FY030_RS08175	COG2706	6-phosphogluconolactonase activity
FY030_RS08205	COG1175	transmembrane transport
FY030_RS08210	COG0395	ABC-type sugar transport system, permease component
FY030_RS08220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS08225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FY030_RS08245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FY030_RS08255	COG1253	flavin adenine dinucleotide binding
FY030_RS08275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY030_RS08280	COG1881	PFAM PEBP family protein
FY030_RS08300	COG1119	ATPase activity
FY030_RS08310	COG0297	glycogen (starch) synthase activity
FY030_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS08345	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS08350	COG1132	(ABC) transporter
FY030_RS08355	COG0488	(ABC) transporter
FY030_RS08375	COG2151	metal-sulfur cluster biosynthetic enzyme
FY030_RS08380	COG0822	iron-sulfur transferase activity
FY030_RS08390	COG0396	ATPase activity
FY030_RS08430	COG1612	heme a metabolic process
FY030_RS08435	COG0109	protoheme IX farnesyltransferase activity
FY030_RS08445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY030_RS08450	COG0166	Belongs to the GPI family
FY030_RS08470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FY030_RS08475	COG0149	triose-phosphate isomerase activity
FY030_RS08480	COG0126	phosphoglycerate kinase activity
FY030_RS08485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FY030_RS08500	COG1660	Displays ATPase and GTPase activities
FY030_RS08505	COG0322	excinuclease ABC activity
FY030_RS08515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY030_RS08520	COG0067	glutamate synthase
FY030_RS08520	COG0069	glutamate synthase activity
FY030_RS08520	COG0070	glutamate synthase
FY030_RS08535	COG5006	permease, DMT superfamily
FY030_RS08540	COG0556	nucleotide-excision repair
FY030_RS08550	COG0539	negative regulation of cytoplasmic translation
FY030_RS08555	COG2226	methyltransferase
FY030_RS08630	COG0133	tryptophan synthase activity
FY030_RS08635	COG0134	indole-3-glycerol-phosphate synthase activity
FY030_RS08645	COG1132	(ABC) transporter
FY030_RS08650	COG1132	(ABC) transporter
FY030_RS08665	COG3201	nicotinamide mononucleotide transporter
FY030_RS08670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FY030_RS08680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY030_RS08700	COG0747	negative chemotaxis
FY030_RS08720	COG1758	RNA polymerase activity
FY030_RS08725	COG0194	GDP metabolic process
FY030_RS08735	COG0284	orotidine-5'-phosphate decarboxylase activity
FY030_RS08750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FY030_RS08755	COG0505	Belongs to the CarA family
FY030_RS08760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY030_RS08765	COG0540	Belongs to the ATCase OTCase family
FY030_RS08770	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FY030_RS08780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY030_RS08785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY030_RS08790	COG0069	glutamate synthase activity
FY030_RS08795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FY030_RS08800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FY030_RS08815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY030_RS08825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FY030_RS08830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY030_RS08855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY030_RS08865	COG0504	CTP synthase activity
FY030_RS08870	COG0438	transferase activity, transferring glycosyl groups
FY030_RS08890	COG0497	DNA recombination
FY030_RS08895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY030_RS08910	COG0647	UMP catabolic process
FY030_RS08935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY030_RS08940	COG2094	Belongs to the DNA glycosylase MPG family
FY030_RS08945	COG0165	Argininosuccinate lyase
FY030_RS08950	COG1438	arginine binding
FY030_RS08965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY030_RS08965	COG0072	phenylalanine-tRNA ligase activity
FY030_RS08970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY030_RS08985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY030_RS08990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY030_RS08995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY030_RS09000	COG0745	RESPONSE REGULATOR receiver
FY030_RS09020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FY030_RS09030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FY030_RS09035	COG0174	glutamine synthetase
FY030_RS09045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS09070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY030_RS09090	COG0557	exoribonuclease II activity
FY030_RS09095	COG3022	response to hydroperoxide
FY030_RS09100	COG0328	RNA-DNA hybrid ribonuclease activity
FY030_RS09100	COG0406	alpha-ribazole phosphatase activity
FY030_RS09110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FY030_RS09130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FY030_RS09135	COG0584	glycerophosphoryl diester phosphodiesterase
FY030_RS09150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY030_RS09155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY030_RS09165	COG0438	transferase activity, transferring glycosyl groups
FY030_RS09185	COG1126	abc transporter atp-binding protein
FY030_RS09190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY030_RS09195	COG0765	amino acid transport
FY030_RS09200	COG0765	amino acid transport
FY030_RS09220	COG2814	Major facilitator Superfamily
FY030_RS09250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FY030_RS09285	COG0693	protein deglycase activity
FY030_RS09310	COG1191	sigma factor activity
FY030_RS09315	COG0423	glycine-tRNA ligase activity
FY030_RS09335	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY030_RS09335	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY030_RS09345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY030_RS09355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY030_RS09360	COG1381	Involved in DNA repair and RecF pathway recombination
FY030_RS09370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY030_RS09370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FY030_RS09370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY030_RS09375	COG1461	Dihydroxyacetone kinase
FY030_RS09380	COG2376	Dihydroxyacetone kinase
FY030_RS09385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY030_RS09395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY030_RS09415	COG0484	heat shock protein binding
FY030_RS09420	COG1420	regulation of RNA biosynthetic process
FY030_RS09425	COG0114	fumarate hydratase activity
FY030_RS09465	COG2326	polyphosphate kinase activity
FY030_RS09470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY030_RS09475	COG0481	GTPase activity
FY030_RS09490	COG0277	FAD linked oxidase domain protein
FY030_RS09495	COG0277	FAD linked oxidase domain protein
FY030_RS09500	COG0247	lactate metabolic process
FY030_RS09505	COG1620	l-lactate permease
FY030_RS09515	COG0406	alpha-ribazole phosphatase activity
FY030_RS09525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY030_RS09535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FY030_RS09540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FY030_RS09545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FY030_RS09550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY030_RS09555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FY030_RS09560	COG1530	ribonuclease E activity
FY030_RS09575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY030_RS09595	COG0772	Belongs to the SEDS family
FY030_RS09605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY030_RS09610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY030_RS09615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY030_RS09615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY030_RS09630	COG0779	Required for maturation of 30S ribosomal subunits
FY030_RS09645	COG1331	Highly conserved protein containing a thioredoxin domain
FY030_RS09660	COG0442	prolyl-tRNA aminoacylation
FY030_RS09675	COG1505	serine-type exopeptidase activity
FY030_RS09685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY030_RS09690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY030_RS09705	COG0456	acetyltransferase
FY030_RS09710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FY030_RS09715	COG0750	zinc metalloprotease
FY030_RS09720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FY030_RS09750	COG2318	DinB family
FY030_RS09770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FY030_RS09775	COG0575	Belongs to the CDS family
FY030_RS09780	COG0233	cytoplasmic translational termination
FY030_RS09785	COG0528	UMP kinase activity
FY030_RS09790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY030_RS09795	COG0052	Belongs to the universal ribosomal protein uS2 family
FY030_RS09825	COG0606	chelatase, subunit chli
FY030_RS09830	COG0792	nuclease activity
FY030_RS09840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY030_RS09855	COG3830	Belongs to the UPF0237 family
FY030_RS09855	COG0560	Phosphoserine phosphatase
FY030_RS09860	COG0336	Belongs to the RNA methyltransferase TrmD family
FY030_RS09865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FY030_RS09870	COG1837	Belongs to the UPF0109 family
FY030_RS09875	COG0228	four-way junction DNA binding
FY030_RS09965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY030_RS09970	COG0571	ribonuclease III activity
FY030_RS09975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FY030_RS09985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY030_RS09995	COG0742	ribosomal rna small subunit methyltransferase
FY030_RS10005	COG1461	Dihydroxyacetone kinase
FY030_RS10010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY030_RS10030	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY030_RS10035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY030_RS10055	COG0776	regulation of translation
FY030_RS10070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY030_RS10080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY030_RS10100	COG0667	Aldo Keto reductase
FY030_RS10110	COG1335	isochorismatase
FY030_RS10135	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FY030_RS10160	COG1678	Uncharacterized ACR, COG1678
FY030_RS10175	COG3842	ATPase activity
FY030_RS10185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY030_RS10190	COG0601	transmembrane transport
FY030_RS10195	COG0747	negative chemotaxis
FY030_RS10200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY030_RS10205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FY030_RS10210	COG4214	carbohydrate transport
FY030_RS10220	COG4213	ABC transporter substrate-binding protein
FY030_RS10225	COG1940	carbohydrate kinase activity
FY030_RS10240	COG1309	transcriptional regulator
FY030_RS10260	COG0546	phosphoglycolate phosphatase activity
FY030_RS10290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY030_RS10295	COG0739	heme binding
FY030_RS10295	COG1196	nuclear chromosome segregation
FY030_RS10295	COG0741	lytic transglycosylase activity
FY030_RS10305	COG2884	Cell division ATP-binding protein ftsE
FY030_RS10320	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FY030_RS10335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY030_RS10445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY030_RS10465	COG2137	regulation of response to DNA damage stimulus
FY030_RS10470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY030_RS10500	COG0825	malonyl-CoA metabolic process
FY030_RS10500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FY030_RS10505	COG1132	(ABC) transporter
FY030_RS10520	COG1201	RNA secondary structure unwinding
FY030_RS10525	COG3842	ATPase activity
FY030_RS10530	COG1653	transport
FY030_RS10540	COG1175	transmembrane transport
FY030_RS10555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY030_RS10560	COG1396	sequence-specific DNA binding
FY030_RS10565	COG1058	Belongs to the CinA family
FY030_RS10565	COG1546	Belongs to the CinA family
FY030_RS10575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY030_RS10580	COG1674	ftsk spoiiie
FY030_RS10590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FY030_RS10595	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY030_RS10605	COG1506	peptidase
FY030_RS10605	COG4946	Tricorn protease homolog
FY030_RS10605	COG0823	Involved in the tonB-independent uptake of proteins
FY030_RS10615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY030_RS10620	COG1960	acyl-CoA dehydrogenase activity
FY030_RS10625	COG0789	Transcriptional regulator
FY030_RS10630	COG4770	biotin carboxylase activity
FY030_RS10645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY030_RS10655	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FY030_RS10675	COG0714	Associated with various cellular activities
FY030_RS10695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FY030_RS10700	COG0662	Cupin 2, conserved barrel domain protein
FY030_RS10700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY030_RS10705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY030_RS10750	COG1473	amidohydrolase
FY030_RS10750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FY030_RS10755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY030_RS10755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY030_RS10760	COG0167	dihydroorotate dehydrogenase activity
FY030_RS10770	COG0438	transferase activity, transferring glycosyl groups
FY030_RS10785	COG0039	L-malate dehydrogenase activity
FY030_RS10795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY030_RS10805	COG0138	bifunctional purine biosynthesis protein purh
FY030_RS10830	COG0045	succinate-CoA ligase (ADP-forming) activity
FY030_RS10870	COG0519	Catalyzes the synthesis of GMP from XMP
FY030_RS10870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FY030_RS10890	COG0516	GMP reductase activity
FY030_RS10905	COG0459	protein refolding
FY030_RS10910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FY030_RS10925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY030_RS10930	COG0456	acetyltransferase
FY030_RS10930	COG1214	PFAM Peptidase M22, glycoprotease
FY030_RS10935	COG0456	acetyltransferase
FY030_RS10935	COG1214	PFAM Peptidase M22, glycoprotease
FY030_RS10960	COG1595	DNA-templated transcription, initiation
FY030_RS10980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FY030_RS10985	COG1162	GTPase activity
FY030_RS10990	COG0483	inositol monophosphate 1-phosphatase activity
FY030_RS11005	COG0612	Peptidase, M16
FY030_RS11015	COG1615	UPF0182 protein
FY030_RS11030	COG3480	Lon protease (S16) C-terminal proteolytic domain
FY030_RS11085	COG0210	DNA helicase
FY030_RS11095	COG1309	transcriptional regulator
FY030_RS11110	COG0513	Belongs to the DEAD box helicase family
FY030_RS11130	COG0006	proline dipeptidase activity
FY030_RS11140	COG2239	Acts as a magnesium transporter
FY030_RS11155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY030_RS11160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY030_RS11170	COG4122	O-methyltransferase activity
FY030_RS11185	COG1024	Enoyl-CoA hydratase
FY030_RS11195	COG0519	Catalyzes the synthesis of GMP from XMP
FY030_RS11230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY030_RS11240	COG0494	nUDIX hydrolase
FY030_RS11245	COG0747	negative chemotaxis
FY030_RS11260	COG0444	Belongs to the ABC transporter superfamily
FY030_RS11265	COG4608	Belongs to the ABC transporter superfamily
FY030_RS11280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FY030_RS11305	COG1621	beta-fructofuranosidase activity
FY030_RS11330	COG1228	amidohydrolase
FY030_RS11340	COG4941	Belongs to the sigma-70 factor family
FY030_RS11350	COG0386	Belongs to the glutathione peroxidase family
FY030_RS11355	COG0277	FAD linked oxidase domain protein
FY030_RS11375	COG0395	ABC-type sugar transport system, permease component
FY030_RS11385	COG1063	alcohol dehydrogenase
FY030_RS11390	COG1070	Carbohydrate kinase
FY030_RS11425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FY030_RS11435	COG1335	isochorismatase
FY030_RS11465	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FY030_RS11490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FY030_RS11505	COG0673	inositol 2-dehydrogenase activity
FY030_RS11545	COG3467	pyridoxamine 5'-phosphate
FY030_RS11550	COG0488	(ABC) transporter
FY030_RS11555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY030_RS11560	COG2188	Transcriptional regulator
FY030_RS11565	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY030_RS11570	COG3395	kinase activity
FY030_RS11610	COG0589	response to stress
FY030_RS11615	COG2838	Isocitrate dehydrogenase
FY030_RS11660	COG2197	response regulator
FY030_RS11680	COG0012	GTP binding
FY030_RS11690	COG1322	Protein conserved in bacteria
FY030_RS11700	COG0765	amino acid transport
FY030_RS11710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FY030_RS11720	COG1570	exodeoxyribonuclease VII activity
FY030_RS11730	COG1722	exodeoxyribonuclease VII activity
FY030_RS11760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY030_RS11765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FY030_RS11770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FY030_RS11780	COG0205	6-phosphofructokinase activity
FY030_RS11800	COG0604	alcohol dehydrogenase
FY030_RS11805	COG0101	tRNA pseudouridine synthase activity
FY030_RS11810	COG0203	ribosomal protein L17
FY030_RS11815	COG0202	RNA polymerase activity
FY030_RS11825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY030_RS11830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY030_RS11835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FY030_RS11840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY030_RS11850	COG0563	adenylate kinase activity
FY030_RS11865	COG1841	ribosomal large subunit assembly
FY030_RS11870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY030_RS11875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY030_RS11880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY030_RS11885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY030_RS11895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FY030_RS11900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FY030_RS11905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY030_RS11910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FY030_RS11915	COG0255	Belongs to the universal ribosomal protein uL29 family
FY030_RS11920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY030_RS11925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY030_RS11930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY030_RS11935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY030_RS11940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY030_RS11945	COG0089	rRNA binding
FY030_RS11950	COG0088	Forms part of the polypeptide exit tunnel
FY030_RS11955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY030_RS11960	COG0051	transcription antitermination factor activity, RNA binding
FY030_RS11975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY030_RS11980	COG0049	tRNA binding
FY030_RS11985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FY030_RS11990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY030_RS11995	COG0085	RNA polymerase activity
FY030_RS12000	COG0222	ribosome binding
FY030_RS12005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY030_RS12020	COG0081	regulation of translation
FY030_RS12025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FY030_RS12045	COG0436	Aminotransferase
FY030_RS12070	COG1131	(ABC) transporter
FY030_RS12080	COG1131	(ABC) transporter
FY030_RS12085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FY030_RS12090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY030_RS12095	COG2030	dehydratase
FY030_RS12100	COG2030	dehydratase
FY030_RS12105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY030_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS12160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY030_RS12165	COG0477	Major facilitator Superfamily
FY030_RS12170	COG1666	GTP binding
FY030_RS12190	COG0501	Belongs to the peptidase M48B family
FY030_RS12195	COG1007	ATP synthesis coupled electron transport
FY030_RS12210	COG0713	ATP synthesis coupled electron transport
FY030_RS12220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY030_RS12250	COG1595	DNA-templated transcription, initiation
FY030_RS12275	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY030_RS12280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY030_RS12300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY030_RS12305	COG0189	ligase activity
FY030_RS12315	COG4133	protoheme IX ABC transporter activity
FY030_RS12325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FY030_RS12335	COG1013	pyruvate-flavodoxin oxidoreductase activity
FY030_RS12350	COG2409	Drug exporters of the RND superfamily
FY030_RS12385	COG1007	ATP synthesis coupled electron transport
FY030_RS12395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY030_RS12400	COG0713	ATP synthesis coupled electron transport
FY030_RS12410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY030_RS12415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FY030_RS12420	COG1034	ATP synthesis coupled electron transport
FY030_RS12425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FY030_RS12440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY030_RS12445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY030_RS12460	COG2176	DNA-directed DNA polymerase activity
FY030_RS12470	COG2226	methyltransferase
FY030_RS12475	COG1169	isochorismate synthase
FY030_RS12480	COG0738	Major facilitator superfamily
FY030_RS12485	COG4552	Acetyltransferase involved in intracellular survival and related
FY030_RS12490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FY030_RS12495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY030_RS12510	COG3590	peptidase
FY030_RS12520	COG3559	Exporter of polyketide antibiotics
FY030_RS12535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY030_RS12540	COG1554	hydrolase, family 65, central catalytic
FY030_RS12545	COG1061	Type III restriction enzyme res subunit
FY030_RS12550	COG0546	phosphoglycolate phosphatase activity
FY030_RS12555	COG0745	RESPONSE REGULATOR receiver
FY030_RS12560	COG2205	protein histidine kinase activity
FY030_RS12570	COG1126	abc transporter atp-binding protein
FY030_RS12575	COG0765	amino acid transport
FY030_RS12580	COG0765	amino acid transport
FY030_RS12590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY030_RS12605	COG3973	AAA domain
FY030_RS12605	COG3973	AAA domain
FY030_RS12610	COG0463	Glycosyl transferase, family 2
FY030_RS12635	COG0459	protein refolding
FY030_RS12640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY030_RS12655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FY030_RS12685	COG1454	alcohol dehydrogenase
FY030_RS12710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY030_RS12735	COG0725	ABC transporter, periplasmic molybdate-binding protein
FY030_RS12750	COG1960	acyl-CoA dehydrogenase activity
FY030_RS12805	COG4139	cobalamin transport
FY030_RS12810	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FY030_RS12855	COG1797	cobyrinic acid a,c-diamide synthase activity
FY030_RS12900	COG1522	sequence-specific DNA binding
FY030_RS12910	COG1473	amidohydrolase
FY030_RS12915	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS12920	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY030_RS12925	COG4948	Mandelate Racemase Muconate Lactonizing
FY030_RS12945	COG2188	Transcriptional regulator
FY030_RS12955	COG0601	transmembrane transport
FY030_RS12965	COG0444	Belongs to the ABC transporter superfamily
FY030_RS12970	COG4608	Belongs to the ABC transporter superfamily
FY030_RS12975	COG4948	Mandelate Racemase Muconate Lactonizing
FY030_RS12985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY030_RS12990	COG0747	negative chemotaxis
FY030_RS13030	COG1396	sequence-specific DNA binding
FY030_RS13045	COG4974	Belongs to the 'phage' integrase family
FY030_RS13100	COG1652	LysM domain
FY030_RS13110	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FY030_RS13125	COG3833	ABC-type maltose transport systems, permease component
FY030_RS13130	COG1175	transmembrane transport
FY030_RS13140	COG3842	ATPase activity
FY030_RS13160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY030_RS13165	COG0215	cysteine-tRNA ligase activity
FY030_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS13195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY030_RS13210	COG0318	PFAM AMP-dependent synthetase and ligase
FY030_RS13215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FY030_RS13220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FY030_RS13245	COG0745	RESPONSE REGULATOR receiver
FY030_RS13250	COG0588	phosphoglycerate mutase activity
FY030_RS13260	COG0438	transferase activity, transferring glycosyl groups
FY030_RS13280	COG1490	D-aminoacyl-tRNA deacylase activity
FY030_RS13290	COG3246	L-lysine catabolic process to acetate
FY030_RS13295	COG0354	folic acid binding
FY030_RS13300	COG1316	TRANSCRIPTIONal
FY030_RS13305	COG4044	May play a role in the intracellular transport of hydrophobic ligands
FY030_RS13315	COG0745	RESPONSE REGULATOR receiver
FY030_RS13320	COG0456	acetyltransferase
FY030_RS13380	COG0517	IMP dehydrogenase activity
FY030_RS13380	COG4175	Glycine betaine
FY030_RS13410	COG0471	metal ion transport
FY030_RS13420	COG0569	domain protein
FY030_RS13425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FY030_RS13460	COG3340	Belongs to the peptidase S51 family
FY030_RS13465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FY030_RS13480	COG0738	Major facilitator superfamily
FY030_RS13495	COG0477	Major facilitator Superfamily
FY030_RS13525	COG0668	transmembrane transport
FY030_RS13530	COG2130	NADP-dependent
FY030_RS13555	COG0784	Response regulator, receiver
FY030_RS13555	COG2198	Histidine kinase
FY030_RS13555	COG2205	protein histidine kinase activity
FY030_RS13580	COG0745	RESPONSE REGULATOR receiver
FY030_RS13585	COG2205	protein histidine kinase activity
FY030_RS13605	COG0512	Glutamine amidotransferase of anthranilate synthase
FY030_RS13605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY030_RS13615	COG1252	NADH dehydrogenase
FY030_RS13625	COG1796	DNA polymerase
FY030_RS13625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FY030_RS13645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY030_RS13660	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FY030_RS13665	COG0129	dihydroxy-acid dehydratase activity
FY030_RS13670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY030_RS13675	COG0440	acetolactate synthase activity
FY030_RS13690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY030_RS13710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FY030_RS13720	COG2873	o-acetylhomoserine
FY030_RS13725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FY030_RS13740	COG0366	Alpha amylase catalytic
FY030_RS13745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS13760	COG1739	Uncharacterized protein family UPF0029
FY030_RS13855	COG0590	tRNA wobble adenosine to inosine editing
FY030_RS13860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY030_RS13865	COG0436	Aminotransferase
FY030_RS13875	COG0242	peptide deformylase activity
FY030_RS13885	COG0436	Aminotransferase
FY030_RS13900	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FY030_RS13915	COG1316	TRANSCRIPTIONal
FY030_RS13925	COG1278	Cold shock
FY030_RS13940	COG1045	serine acetyltransferase
FY030_RS13955	COG1876	peptidase activity
FY030_RS13965	COG0717	Belongs to the dCTP deaminase family
FY030_RS13975	COG1324	tolerance protein
FY030_RS13980	COG0318	PFAM AMP-dependent synthetase and ligase
FY030_RS13990	COG0546	phosphoglycolate phosphatase activity
FY030_RS13995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY030_RS13995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY030_RS14010	COG0438	transferase activity, transferring glycosyl groups
FY030_RS14025	COG3191	aminopeptidase activity
FY030_RS14030	COG4608	Belongs to the ABC transporter superfamily
FY030_RS14050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS14055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY030_RS14065	COG0747	negative chemotaxis
FY030_RS14070	COG1960	acyl-CoA dehydrogenase activity
FY030_RS14100	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY030_RS14135	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY030_RS14140	COG0022	dehydrogenase e1 component
FY030_RS14155	COG1950	PFAM Membrane protein of
FY030_RS14160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY030_RS14175	COG0351	phosphomethylpyrimidine kinase
FY030_RS14195	COG1595	DNA-templated transcription, initiation
FY030_RS14215	COG1132	(ABC) transporter
FY030_RS14225	COG0438	transferase activity, transferring glycosyl groups
FY030_RS14235	COG1309	transcriptional regulator
FY030_RS14240	COG1131	(ABC) transporter
FY030_RS14245	COG3559	Exporter of polyketide antibiotics
FY030_RS14250	COG0745	RESPONSE REGULATOR receiver
FY030_RS14255	COG2205	protein histidine kinase activity
FY030_RS14280	COG3842	ATPase activity
FY030_RS14290	COG1764	response to oxidative stress
FY030_RS14315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY030_RS14345	COG0489	protein tyrosine kinase activity
FY030_RS14345	COG3206	protein involved in exopolysaccharide biosynthesis
FY030_RS14380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY030_RS14390	COG2186	Transcriptional regulator
FY030_RS14395	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY030_RS14400	COG1129	ABC transporter
FY030_RS14405	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY030_RS14410	COG1879	ABC-type sugar transport system periplasmic component
FY030_RS14420	COG0800	Aldolase
FY030_RS14435	COG1063	alcohol dehydrogenase
FY030_RS14440	COG1082	Xylose isomerase domain protein TIM barrel
FY030_RS14445	COG1063	alcohol dehydrogenase
FY030_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS14455	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS14465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY030_RS14470	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY030_RS14475	COG1129	ABC transporter
FY030_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS14490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY030_RS14500	COG2140	Oxalate decarboxylase
FY030_RS14505	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS14515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY030_RS14530	COG1086	Polysaccharide biosynthesis protein
FY030_RS14535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FY030_RS14545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FY030_RS14580	COG0489	protein tyrosine kinase activity
FY030_RS14590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY030_RS14600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FY030_RS14615	COG0579	oxidoreductase
FY030_RS14625	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FY030_RS14635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FY030_RS14665	COG1442	glycosyl transferase family 8
FY030_RS14665	COG1216	Glycosyl transferase, family 2
FY030_RS14680	COG0110	maltose O-acetyltransferase activity
FY030_RS14690	COG0438	transferase activity, transferring glycosyl groups
FY030_RS14700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY030_RS14700	COG2755	lipolytic protein G-D-S-L family
FY030_RS14715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FY030_RS14735	COG4585	Histidine kinase
FY030_RS14740	COG2197	response regulator
FY030_RS14745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FY030_RS14750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY030_RS14755	COG2171	N-acyltransferase activity
FY030_RS14760	COG0436	Aminotransferase
FY030_RS14780	COG1088	dTDP-glucose 4,6-dehydratase activity
FY030_RS14790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FY030_RS14820	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY030_RS14825	COG1115	amino acid carrier protein
FY030_RS14850	COG1074	ATP-dependent DNA helicase activity
FY030_RS14855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY030_RS14865	COG4591	ABC-type transport system involved in lipoprotein release permease component
FY030_RS14870	COG0577	efflux transmembrane transporter activity
FY030_RS14870	COG1136	(ABC) transporter
FY030_RS14880	COG2076	Multidrug Resistance protein
FY030_RS14885	COG2197	response regulator
FY030_RS14890	COG4585	Histidine kinase
FY030_RS14895	COG0442	prolyl-tRNA aminoacylation
FY030_RS14905	COG2610	gluconate transmembrane transporter activity
FY030_RS14910	COG3265	gluconokinase activity
FY030_RS14925	COG0058	SHG alpha-glucan phosphorylase activity
FY030_RS14960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FY030_RS14965	COG0604	alcohol dehydrogenase
FY030_RS14970	COG1051	belongs to the nudix hydrolase family
FY030_RS14985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FY030_RS14985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FY030_RS15025	COG1404	Belongs to the peptidase S8 family
FY030_RS15030	COG0339	signal peptide processing
FY030_RS15035	COG1846	Transcriptional regulator
FY030_RS15040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY030_RS15070	COG1268	BioY protein
FY030_RS15080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FY030_RS15085	COG2375	cellular response to nickel ion
FY030_RS15095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY030_RS15100	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY030_RS15105	COG1120	ATPase activity
FY030_RS15110	COG2409	Drug exporters of the RND superfamily
FY030_RS15120	COG0315	cyclic pyranopterin monophosphate synthase activity
FY030_RS15120	COG0521	Mo-molybdopterin cofactor biosynthetic process
FY030_RS15125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FY030_RS15135	COG0746	molybdenum cofactor guanylyltransferase activity
FY030_RS15150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FY030_RS15155	COG1140	nitrate reductase beta subunit
FY030_RS15195	COG2132	Multicopper oxidase
FY030_RS15210	COG2814	Major facilitator Superfamily
FY030_RS15215	COG2149	membrane
FY030_RS15230	COG1921	L-seryl-tRNASec selenium transferase activity
FY030_RS15235	COG0709	Synthesizes selenophosphate from selenide and ATP
FY030_RS15250	COG0437	4 iron, 4 sulfur cluster binding
FY030_RS15280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY030_RS15290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FY030_RS15325	COG3275	phosphorelay sensor kinase activity
FY030_RS15330	COG0477	Major facilitator Superfamily
FY030_RS15335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY030_RS15345	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS15350	COG0753	catalase activity
FY030_RS15360	COG0667	Aldo Keto reductase
FY030_RS15390	COG0183	Belongs to the thiolase family
FY030_RS15400	COG0318	PFAM AMP-dependent synthetase and ligase
FY030_RS15405	COG1042	CoA-binding domain protein
FY030_RS15405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FY030_RS15405	COG0045	succinate-CoA ligase (ADP-forming) activity
FY030_RS15455	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY030_RS15470	COG1028	Short-chain dehydrogenase reductase Sdr
FY030_RS15475	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FY030_RS15480	COG0406	alpha-ribazole phosphatase activity
FY030_RS15480	COG0328	RNA-DNA hybrid ribonuclease activity
FY030_RS15485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY030_RS15490	COG1404	Belongs to the peptidase S8 family
FY030_RS15490	COG4412	M6 family metalloprotease domain protein
FY030_RS15510	COG1266	CAAX protease self-immunity
FY030_RS15520	COG0300	oxidoreductase activity
FY030_RS15525	COG1230	cation diffusion facilitator family transporter
FY030_RS15560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FY030_RS15565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY030_RS15570	COG1120	ATPase activity
FY030_RS15575	COG1492	cobalamin metabolic process
FY030_RS15585	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FY030_RS15595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FY030_RS15600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FY030_RS15610	COG4067	protein conserved in archaea
FY030_RS15610	COG0189	ligase activity
FY030_RS15615	COG0569	domain protein
FY030_RS15615	COG0189	ligase activity
FY030_RS15635	COG0657	acetylesterase activity
FY030_RS15660	COG1476	TRANSCRIPTIONal
FY030_RS15705	COG1929	Belongs to the glycerate kinase type-1 family
FY030_RS15710	COG2252	PERMEase
FY030_RS15715	COG1819	glycosyl
FY030_RS15730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY030_RS15735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY030_RS15750	COG4585	Histidine kinase
FY030_RS15770	COG4106	trans-aconitate 2-methyltransferase activity
FY030_RS15815	COG0662	Cupin 2, conserved barrel domain protein
FY030_RS15835	COG0205	6-phosphofructokinase activity
FY030_RS15845	COG1819	glycosyl
FY030_RS15900	COG3655	Transcriptional regulator
FY030_RS15920	COG0018	arginyl-trna synthetase
FY030_RS15925	COG1846	Transcriptional regulator
FY030_RS15930	COG0697	spore germination
FY030_RS15960	COG2226	methyltransferase
FY030_RS15965	COG0305	Participates in initiation and elongation during chromosome replication
FY030_RS15975	COG0534	Mate efflux family protein
FY030_RS15980	COG1320	monovalent cation:proton antiporter activity
FY030_RS15985	COG2212	antiporter activity
FY030_RS16005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY030_RS16005	COG2111	Na H antiporter
FY030_RS16010	COG0359	binds to the 23S rRNA
FY030_RS16015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY030_RS16025	COG0360	Binds together with S18 to 16S ribosomal RNA
FY030_RS16050	COG1134	teichoic acid transport
FY030_RS16085	COG1215	transferase activity, transferring glycosyl groups
FY030_RS16115	COG1260	myo-inositol-1-phosphate synthase
FY030_RS16120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY030_RS16130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY030_RS16130	COG2755	lipolytic protein G-D-S-L family
FY030_RS16140	COG0617	tRNA 3'-terminal CCA addition
FY030_RS16155	COG0515	serine threonine protein kinase
FY030_RS16155	COG2815	serine threonine protein kinase
FY030_RS16160	COG1595	DNA-templated transcription, initiation
FY030_RS16175	COG3118	belongs to the thioredoxin family
FY030_RS16185	COG1192	Involved in chromosome partitioning
FY030_RS16190	COG0357	Ribosomal RNA small subunit methyltransferase G
FY030_RS16200	COG0706	membrane insertase activity
FY030_RS16205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FY030_RS16215	COG0230	Belongs to the bacterial ribosomal protein bL34 family