locus-tag	class	description
I6I38_RS00010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I38_RS00015	COG4206	TonB-dependent receptor
I6I38_RS00020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I38_RS00060	COG1879	ABC-type sugar transport system periplasmic component
I6I38_RS00065	COG1129	ABC transporter
I6I38_RS00070	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS00075	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS00080	COG0583	DNA-binding transcription factor activity
I6I38_RS00085	COG3085	chromosome segregation
I6I38_RS00090	COG0606	chelatase, subunit chli
I6I38_RS00095	COG2814	Major facilitator Superfamily
I6I38_RS00110	COG3978	acetolactate synthase activity
I6I38_RS00115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I38_RS00120	COG0129	dihydroxy-acid dehydratase activity
I6I38_RS00125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I38_RS00135	COG0583	DNA-binding transcription factor activity
I6I38_RS00140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I38_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS00150	COG1942	4-Oxalocrotonate Tautomerase
I6I38_RS00155	COG2200	EAL domain
I6I38_RS00160	COG2982	Protein involved in outer membrane biogenesis
I6I38_RS00165	COG2134	cdp-diacylglycerol pyrophosphatase
I6I38_RS00170	COG0477	Major facilitator Superfamily
I6I38_RS00175	COG1295	ribonuclease BN
I6I38_RS00180	COG1024	Enoyl-CoA hydratase
I6I38_RS00185	COG5001	Diguanylate cyclase
I6I38_RS00190	COG3678	ATP-independent chaperone mediated protein folding
I6I38_RS00215	COG2205	protein histidine kinase activity
I6I38_RS00215	COG0784	Response regulator, receiver
I6I38_RS00225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I38_RS00230	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I38_RS00245	COG0154	amidase activity
I6I38_RS00255	COG0339	signal peptide processing
I6I38_RS00260	COG0742	ribosomal rna small subunit methyltransferase
I6I38_RS00265	COG0737	Belongs to the 5'-nucleotidase family
I6I38_RS00270	COG0517	IMP dehydrogenase activity
I6I38_RS00270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I38_RS00280	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS00285	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS00290	COG1129	ABC transporter
I6I38_RS00305	COG0589	response to stress
I6I38_RS00315	COG0306	phosphate transporter
I6I38_RS00320	COG2081	HI0933 family
I6I38_RS00365	COG2197	response regulator
I6I38_RS00395	COG3188	usher protein
I6I38_RS00425	COG4619	ABC transporter
I6I38_RS00430	COG0390	transport system, permease component
I6I38_RS00440	COG2814	Major facilitator Superfamily
I6I38_RS00440	COG0477	Major facilitator Superfamily
I6I38_RS00450	COG3718	enzyme involved in inositol metabolism
I6I38_RS00460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS00465	COG3962	Belongs to the TPP enzyme family
I6I38_RS00470	COG0673	inositol 2-dehydrogenase activity
I6I38_RS00475	COG1082	Xylose isomerase domain protein TIM barrel
I6I38_RS00480	COG1082	Xylose isomerase domain protein TIM barrel
I6I38_RS00485	COG3191	aminopeptidase activity
I6I38_RS00490	COG1247	-acetyltransferase
I6I38_RS00495	COG1741	Belongs to the pirin family
I6I38_RS00500	COG1609	Transcriptional regulator
I6I38_RS00505	COG2610	gluconate transmembrane transporter activity
I6I38_RS00510	COG3265	gluconokinase activity
I6I38_RS00515	COG2095	MarC family integral membrane protein
I6I38_RS00520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I38_RS00525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I38_RS00530	COG1523	belongs to the glycosyl hydrolase 13 family
I6I38_RS00535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I38_RS00540	COG0297	glycogen (starch) synthase activity
I6I38_RS00545	COG0058	SHG alpha-glucan phosphorylase activity
I6I38_RS00550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I38_RS00555	COG1349	DNA-binding transcription factor activity
I6I38_RS00560	COG0705	Rhomboid family
I6I38_RS00565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I38_RS00575	COG2909	trisaccharide binding
I6I38_RS00580	COG0058	SHG alpha-glucan phosphorylase activity
I6I38_RS00585	COG1640	4-alpha-glucanotransferase
I6I38_RS00590	COG0316	Belongs to the HesB IscA family
I6I38_RS00590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I38_RS00595	COG1040	competence protein
I6I38_RS00600	COG2267	carboxylic ester hydrolase activity
I6I38_RS00620	COG1918	ferrous iron import across plasma membrane
I6I38_RS00625	COG2183	response to ionizing radiation
I6I38_RS00630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I38_RS00660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I38_RS00665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I38_RS00670	COG1011	Hydrolase
I6I38_RS00680	COG0494	nUDIX hydrolase
I6I38_RS00685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I38_RS00710	COG4796	Type ii and iii secretion system protein
I6I38_RS00720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I38_RS00725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I38_RS00745	COG0546	phosphoglycolate phosphatase activity
I6I38_RS00750	COG0180	Tryptophanyl-tRNA synthetase
I6I38_RS00755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I38_RS00755	COG1648	precorrin-2 dehydrogenase activity
I6I38_RS00770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I38_RS00775	COG0402	S-adenosylhomocysteine deaminase activity
I6I38_RS00780	COG0738	Major facilitator superfamily
I6I38_RS00785	COG1609	Transcriptional regulator
I6I38_RS00790	COG1486	melibiose metabolic process
I6I38_RS00795	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I38_RS00800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I38_RS00805	COG3275	phosphorelay sensor kinase activity
I6I38_RS00825	COG0433	COG0433 Predicted ATPase
I6I38_RS00840	COG1289	transmembrane transporter activity
I6I38_RS00845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I38_RS00850	COG1765	OsmC-like protein
I6I38_RS00855	COG3954	Phosphoribulokinase
I6I38_RS00860	COG3089	Belongs to the UPF0270 family
I6I38_RS00865	COG0429	hydrolase of the alpha beta-hydrolase fold
I6I38_RS00880	COG4521	taurine ABC transporter
I6I38_RS00890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I38_RS00895	COG2175	clavaminate synthase activity
I6I38_RS00900	COG0488	(ABC) transporter
I6I38_RS00905	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I38_RS00915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I38_RS00920	COG1047	Peptidyl-prolyl cis-trans
I6I38_RS00925	COG2900	Belongs to the SlyX family
I6I38_RS00930	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I38_RS00935	COG2964	Protein conserved in bacteria
I6I38_RS00940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I38_RS00945	COG2923	Belongs to the DsrF TusC family
I6I38_RS00950	COG2168	tRNA wobble position uridine thiolation
I6I38_RS00955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I38_RS00960	COG0049	tRNA binding
I6I38_RS00965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I38_RS00970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I38_RS00985	COG0051	transcription antitermination factor activity, RNA binding
I6I38_RS00990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I38_RS00995	COG0088	Forms part of the polypeptide exit tunnel
I6I38_RS01000	COG0089	rRNA binding
I6I38_RS01005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I38_RS01010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I38_RS01020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I38_RS01025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I38_RS01030	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I38_RS01035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I38_RS01040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I38_RS01045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I38_RS01050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I38_RS01055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I38_RS01065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I38_RS01070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I38_RS01075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I38_RS01085	COG0200	Binds to the 23S rRNA
I6I38_RS01090	COG0201	protein transport
I6I38_RS01095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I38_RS01100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I38_RS01105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I38_RS01110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I38_RS01115	COG0202	RNA polymerase activity
I6I38_RS01120	COG0203	ribosomal protein L17
I6I38_RS01130	COG0789	Transcriptional regulator
I6I38_RS01135	COG3036	rescue of stalled ribosome
I6I38_RS01140	COG1970	mechanosensitive ion channel activity
I6I38_RS01145	COG0569	domain protein
I6I38_RS01150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I38_RS01150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I38_RS01155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I38_RS01160	COG0242	peptide deformylase activity
I6I38_RS01165	COG0758	DNA mediated transformation
I6I38_RS01170	COG2922	Belongs to the Smg family
I6I38_RS01175	COG0551	DNA topoisomerase type I activity
I6I38_RS01180	COG0009	L-threonylcarbamoyladenylate synthase
I6I38_RS01185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I38_RS01190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I38_RS01225	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6I38_RS01230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I38_RS01240	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I38_RS01245	COG0800	Aldolase
I6I38_RS01250	COG0129	dihydroxy-acid dehydratase activity
I6I38_RS01255	COG2610	gluconate transmembrane transporter activity
I6I38_RS01260	COG3265	gluconokinase activity
I6I38_RS01280	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6I38_RS01285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I38_RS01290	COG3457	Alanine racemase
I6I38_RS01305	COG2188	Transcriptional regulator
I6I38_RS01310	COG1414	Transcriptional regulator
I6I38_RS01315	COG1410	methionine synthase
I6I38_RS01315	COG0646	methionine synthase
I6I38_RS01320	COG2188	Transcriptional regulator
I6I38_RS01335	COG4149	molybdate abc transporter
I6I38_RS01345	COG3842	ATPase activity
I6I38_RS01350	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I38_RS01370	COG0527	aspartate kinase activity
I6I38_RS01380	COG0166	Belongs to the GPI family
I6I38_RS01390	COG3223	Belongs to the PsiE family
I6I38_RS01395	COG3833	ABC-type maltose transport systems, permease component
I6I38_RS01400	COG1175	transmembrane transport
I6I38_RS01405	COG2182	Extracellular solute-binding protein
I6I38_RS01410	COG0366	Alpha amylase catalytic
I6I38_RS01420	COG4580	involved in the transport of maltose and maltodextrins
I6I38_RS01435	COG1609	Transcriptional regulator
I6I38_RS01440	COG0477	Major facilitator Superfamily
I6I38_RS01445	COG3161	chorismate lyase activity
I6I38_RS01450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I38_RS01455	COG2937	Belongs to the GPAT DAPAT family
I6I38_RS01460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I38_RS01465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I38_RS01470	COG0534	Mate efflux family protein
I6I38_RS01475	COG3237	CsbD-like
I6I38_RS01480	COG0735	belongs to the Fur family
I6I38_RS01490	COG1595	DNA-templated transcription, initiation
I6I38_RS01500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I38_RS01515	COG0604	alcohol dehydrogenase
I6I38_RS01535	COG1522	sequence-specific DNA binding
I6I38_RS01540	COG1448	Aminotransferase
I6I38_RS01550	COG2315	Protein conserved in bacteria
I6I38_RS01555	COG0110	maltose O-acetyltransferase activity
I6I38_RS01560	COG1064	alcohol dehydrogenase
I6I38_RS01565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I38_RS01570	COG0629	single-stranded DNA binding
I6I38_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS01580	COG0583	DNA-binding transcription factor activity
I6I38_RS01590	COG0625	glutathione transferase activity
I6I38_RS01600	COG2252	PERMEase
I6I38_RS01605	COG0025	NhaP-type Na H and K H
I6I38_RS01610	COG0583	DNA-binding transcription factor activity
I6I38_RS01615	COG1380	Effector of murein hydrolase LrgA
I6I38_RS01625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I38_RS01625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I38_RS01635	COG1560	Kdo2-lipid A biosynthetic process
I6I38_RS01645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I38_RS01650	COG0076	glutamate decarboxylase activity
I6I38_RS01670	COG2264	protein methyltransferase activity
I6I38_RS01675	COG4145	pantothenate transmembrane transporter activity
I6I38_RS01680	COG3924	membrane
I6I38_RS01685	COG0439	Biotin carboxylase
I6I38_RS01690	COG0511	ligase activity, forming carbon-carbon bonds
I6I38_RS01695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I38_RS01700	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I38_RS01705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I38_RS01710	COG0604	alcohol dehydrogenase
I6I38_RS01715	COG2200	EAL domain
I6I38_RS01715	COG2199	diguanylate cyclase activity
I6I38_RS01720	COG1077	Cell shape determining protein MreB Mrl
I6I38_RS01725	COG1792	Involved in formation and maintenance of cell shape
I6I38_RS01730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I38_RS01735	COG0424	maF-like protein
I6I38_RS01740	COG1530	ribonuclease E activity
I6I38_RS01745	COG3164	Protein of unknown function
I6I38_RS01750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I38_RS01755	COG0312	modulator of DNA gyrase
I6I38_RS01775	COG3210	domain, Protein
I6I38_RS01805	COG0583	DNA-binding transcription factor activity
I6I38_RS01815	COG1566	PFAM secretion protein HlyD family protein
I6I38_RS01820	COG1289	transmembrane transporter activity
I6I38_RS01830	COG2732	(Barnase) inhibitor
I6I38_RS01835	COG3028	Belongs to the UPF0307 family
I6I38_RS01840	COG0312	modulator of DNA gyrase
I6I38_RS01845	COG3783	Cytochrome b(562)
I6I38_RS01850	COG2207	Transcriptional regulator
I6I38_RS01860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I38_RS01890	COG3964	amidohydrolase
I6I38_RS01905	COG2706	6-phosphogluconolactonase activity
I6I38_RS01910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I38_RS01910	COG3711	transcriptional antiterminator
I6I38_RS01915	COG5499	transcription regulator containing HTH domain
I6I38_RS01920	COG4680	protein conserved in bacteria
I6I38_RS01925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I38_RS01930	COG1660	Displays ATPase and GTPase activities
I6I38_RS01945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I38_RS01950	COG1137	ATPase activity
I6I38_RS01955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I38_RS01960	COG3117	lipopolysaccharide transmembrane transporter activity
I6I38_RS01965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I38_RS01970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I38_RS01970	COG0517	IMP dehydrogenase activity
I6I38_RS01975	COG0530	calcium, potassium:sodium antiporter activity
I6I38_RS01985	COG1127	ABC transporter
I6I38_RS01990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I38_RS01995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I38_RS02000	COG2854	intermembrane phospholipid transfer
I6I38_RS02005	COG3113	response to antibiotic
I6I38_RS02010	COG5007	Belongs to the BolA IbaG family
I6I38_RS02015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I38_RS02020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I38_RS02025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I38_RS02030	COG3105	Protein conserved in bacteria
I6I38_RS02035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I38_RS02040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I38_RS02045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I38_RS02050	COG0625	glutathione transferase activity
I6I38_RS02055	COG2969	positive regulation of protein catabolic process
I6I38_RS02065	COG0493	'glutamate synthase
I6I38_RS02070	COG0067	glutamate synthase
I6I38_RS02070	COG0070	glutamate synthase
I6I38_RS02070	COG0069	glutamate synthase activity
I6I38_RS02075	COG1242	4 iron, 4 sulfur cluster binding
I6I38_RS02080	COG5002	protein histidine kinase activity
I6I38_RS02080	COG2198	Histidine kinase
I6I38_RS02080	COG0784	Response regulator, receiver
I6I38_RS02085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6I38_RS02100	COG2823	Periplasmic or secreted lipoprotein
I6I38_RS02105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I38_RS02110	COG0792	nuclease activity
I6I38_RS02115	COG3107	peptidoglycan biosynthetic process
I6I38_RS02120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I38_RS02130	COG1741	Belongs to the pirin family
I6I38_RS02135	COG0583	DNA-binding transcription factor activity
I6I38_RS02140	COG0435	Glutathione S-transferase
I6I38_RS02145	COG2259	Doxx family
I6I38_RS02155	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6I38_RS02160	COG4575	ribosome binding
I6I38_RS02170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I38_RS02175	COG0586	Pfam SNARE associated Golgi protein
I6I38_RS02190	COG2271	Major facilitator Superfamily
I6I38_RS02195	COG1904	glucuronate isomerase
I6I38_RS02200	COG2721	sulfolactate sulfo-lyase activity
I6I38_RS02205	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I38_RS02210	COG0861	Integral membrane protein TerC family
I6I38_RS02215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I38_RS02215	COG0519	Catalyzes the synthesis of GMP from XMP
I6I38_RS02220	COG0673	inositol 2-dehydrogenase activity
I6I38_RS02225	COG1451	nucleotide metabolic process
I6I38_RS02230	COG2813	Specifically methylates the guanine in position
I6I38_RS02235	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I38_RS02235	COG1902	pentaerythritol trinitrate reductase activity
I6I38_RS02250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I38_RS02255	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS02265	COG0625	glutathione transferase activity
I6I38_RS02280	COG3663	DNA glycosylase
I6I38_RS02295	COG0358	DNA primase activity
I6I38_RS02300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I38_RS02305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I38_RS02315	COG1132	(ABC) transporter
I6I38_RS02315	COG2375	cellular response to nickel ion
I6I38_RS02320	COG4774	siderophore transport
I6I38_RS02325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I38_RS02330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I38_RS02335	COG1968	undecaprenyl-diphosphatase activity
I6I38_RS02340	COG0617	tRNA 3'-terminal CCA addition
I6I38_RS02345	COG4991	sh3 domain protein
I6I38_RS02350	COG3025	triphosphatase activity
I6I38_RS02355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I38_RS02360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I38_RS02360	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I38_RS02365	COG0531	amino acid
I6I38_RS02370	COG2960	long-chain fatty acid transporting porin activity
I6I38_RS02375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I38_RS02385	COG3384	dioxygenase
I6I38_RS02390	COG1609	Transcriptional regulator
I6I38_RS02405	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I38_RS02405	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS02410	COG3715	PTS system
I6I38_RS02415	COG3716	PTS system mannose fructose sorbose family IID component
I6I38_RS02425	COG2140	Oxalate decarboxylase
I6I38_RS02430	COG0754	glutathionylspermidine amidase activity
I6I38_RS02435	COG5463	Belongs to the UPF0441 family
I6I38_RS02445	COG2376	Dihydroxyacetone kinase
I6I38_RS02450	COG1461	Dihydroxyacetone kinase
I6I38_RS02465	COG1312	Catalyzes the dehydration of D-mannonate
I6I38_RS02470	COG1538	Outer membrane efflux protein
I6I38_RS02475	COG0494	nUDIX hydrolase
I6I38_RS02480	COG3151	Protein conserved in bacteria
I6I38_RS02485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I38_RS02490	COG3150	esterase
I6I38_RS02500	COG0583	DNA-binding transcription factor activity
I6I38_RS02505	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I38_RS02510	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I38_RS02520	COG0204	Acyl-transferase
I6I38_RS02525	COG2132	Multicopper oxidase
I6I38_RS02530	COG3240	lipase activity
I6I38_RS02535	COG0583	DNA-binding transcription factor activity
I6I38_RS02560	COG0583	DNA-binding transcription factor activity
I6I38_RS02565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6I38_RS02570	COG2211	Major facilitator Superfamily
I6I38_RS02575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS02585	COG0741	lytic transglycosylase activity
I6I38_RS02590	COG1940	carbohydrate kinase activity
I6I38_RS02595	COG0457	Tetratricopeptide repeat
I6I38_RS02600	COG2814	Major facilitator Superfamily
I6I38_RS02600	COG0477	Major facilitator Superfamily
I6I38_RS02605	COG1879	ABC-type sugar transport system periplasmic component
I6I38_RS02610	COG1129	ABC transporter
I6I38_RS02615	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS02620	COG1063	alcohol dehydrogenase
I6I38_RS02625	COG2017	converts alpha-aldose to the beta-anomer
I6I38_RS02635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I38_RS02640	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I38_RS02645	COG2723	6-phospho-beta-galactosidase activity
I6I38_RS02655	COG0402	S-adenosylhomocysteine deaminase activity
I6I38_RS02660	COG0656	L-ascorbic acid biosynthetic process
I6I38_RS02665	COG1979	alcohol dehydrogenase
I6I38_RS02670	COG2207	Transcriptional regulator
I6I38_RS02675	COG0604	alcohol dehydrogenase
I6I38_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS02675	COG3321	synthase
I6I38_RS02680	COG0583	DNA-binding transcription factor activity
I6I38_RS02685	COG0586	Pfam SNARE associated Golgi protein
I6I38_RS02700	COG0848	biopolymer transport protein
I6I38_RS02705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I38_RS02735	COG2831	hemolysin activation secretion protein
I6I38_RS02740	COG2994	toxin metabolic process
I6I38_RS02745	COG3210	domain, Protein
I6I38_RS02790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6I38_RS02795	COG1473	amidohydrolase
I6I38_RS02800	COG1473	amidohydrolase
I6I38_RS02805	COG0583	DNA-binding transcription factor activity
I6I38_RS02810	COG4772	TonB-dependent receptor
I6I38_RS02825	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I38_RS02825	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I38_RS02850	COG0454	-acetyltransferase
I6I38_RS02870	COG1982	Orn Lys Arg decarboxylase major
I6I38_RS02875	COG0741	lytic transglycosylase activity
I6I38_RS02880	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I38_RS02890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I38_RS02895	COG3171	Protein conserved in bacteria
I6I38_RS02900	COG2066	Belongs to the glutaminase family
I6I38_RS02915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I38_RS02920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I38_RS02925	COG1872	DUF167
I6I38_RS02930	COG0762	integral membrane protein
I6I38_RS02935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I38_RS02940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I38_RS02945	COG2805	Type II/IV secretion system protein
I6I38_RS02950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I38_RS02955	COG1678	Uncharacterized ACR, COG1678
I6I38_RS02960	COG0189	ligase activity
I6I38_RS02965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I38_RS02970	COG2356	endonuclease I
I6I38_RS02975	COG3091	SprT-like family
I6I38_RS02980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I38_RS02980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I38_RS02985	COG3708	Transcriptional regulator
I6I38_RS02985	COG2207	Transcriptional regulator
I6I38_RS02990	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I38_RS03000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I38_RS03000	COG2010	Cytochrome c
I6I38_RS03010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I38_RS03010	COG2010	Cytochrome c
I6I38_RS03015	COG1113	amino acid transport
I6I38_RS03020	COG2186	Transcriptional regulator
I6I38_RS03025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I38_RS03030	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I38_RS03035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I38_RS03050	COG3112	Uncharacterised protein family (UPF0231)
I6I38_RS03055	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I38_RS03060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I38_RS03070	COG2132	Multicopper oxidase
I6I38_RS03080	COG0288	reversible hydration of carbon dioxide
I6I38_RS03085	COG1131	(ABC) transporter
I6I38_RS03090	COG0842	Transport permease protein
I6I38_RS03095	COG0726	polysaccharide deacetylase
I6I38_RS03100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I38_RS03105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I38_RS03110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I38_RS03120	COG0642	Histidine kinase
I6I38_RS03125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I38_RS03130	COG0617	tRNA 3'-terminal CCA addition
I6I38_RS03135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I38_RS03145	COG1489	DNA binding
I6I38_RS03150	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I38_RS03155	COG1643	Atp-dependent helicase
I6I38_RS03160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I38_RS03165	COG4774	siderophore transport
I6I38_RS03170	COG1120	ATPase activity
I6I38_RS03175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I38_RS03180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I38_RS03200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I38_RS03210	COG1166	arginine decarboxylase activity
I6I38_RS03215	COG0010	Belongs to the arginase family
I6I38_RS03220	COG1187	pseudouridine synthase activity
I6I38_RS03225	COG2271	Major facilitator Superfamily
I6I38_RS03230	COG2146	nitrite reductase [NAD(P)H] activity
I6I38_RS03250	COG1414	Transcriptional regulator
I6I38_RS03265	COG2271	Major facilitator Superfamily
I6I38_RS03275	COG2267	carboxylic ester hydrolase activity
I6I38_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS03285	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I38_RS03300	COG0501	Belongs to the peptidase M48B family
I6I38_RS03305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I38_RS03315	COG1175	transmembrane transport
I6I38_RS03320	COG3842	ATPase activity
I6I38_RS03325	COG0473	3-isopropylmalate dehydrogenase activity
I6I38_RS03330	COG0583	DNA-binding transcription factor activity
I6I38_RS03335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I38_RS03340	COG0126	phosphoglycerate kinase activity
I6I38_RS03345	COG0191	fructose-bisphosphate aldolase activity
I6I38_RS03360	COG2271	Major facilitator Superfamily
I6I38_RS03370	COG0235	Class ii aldolase
I6I38_RS03375	COG3623	hexulose-6-phosphate isomerase
I6I38_RS03380	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6I38_RS03385	COG1070	Carbohydrate kinase
I6I38_RS03395	COG2731	YhcH YjgK YiaL family protein
I6I38_RS03415	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS03420	COG1129	ABC transporter
I6I38_RS03425	COG1414	Transcriptional regulator
I6I38_RS03430	COG1279	arginine transmembrane transporter activity
I6I38_RS03440	COG0583	DNA-binding transcription factor activity
I6I38_RS03450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I38_RS03455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I38_RS03465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6I38_RS03470	COG3079	Belongs to the UPF0149 family
I6I38_RS03475	COG0006	proline dipeptidase activity
I6I38_RS03480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I38_RS03485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I38_RS03490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I38_RS03495	COG0509	glycine decarboxylation via glycine cleavage system
I6I38_RS03500	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I38_RS03500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I38_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS03575	COG1272	protein, Hemolysin III
I6I38_RS03585	COG0354	folic acid binding
I6I38_RS03590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I38_RS03600	COG0745	RESPONSE REGULATOR receiver
I6I38_RS03605	COG2205	protein histidine kinase activity
I6I38_RS03610	COG4452	Inner membrane protein CreD
I6I38_RS03615	COG0716	FMN binding
I6I38_RS03620	COG4974	Belongs to the 'phage' integrase family
I6I38_RS03625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I38_RS03630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I38_RS03640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I38_RS03660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I38_RS03670	COG5002	protein histidine kinase activity
I6I38_RS03670	COG2205	protein histidine kinase activity
I6I38_RS03670	COG0784	Response regulator, receiver
I6I38_RS03675	COG2197	response regulator
I6I38_RS03695	COG0484	heat shock protein binding
I6I38_RS03700	COG3247	response to pH
I6I38_RS03705	COG0583	DNA-binding transcription factor activity
I6I38_RS03710	COG1335	isochorismatase
I6I38_RS03715	COG5265	(ABC) transporter
I6I38_RS03720	COG1942	4-Oxalocrotonate Tautomerase
I6I38_RS03730	COG1304	FMN binding
I6I38_RS03735	COG1620	l-lactate permease
I6I38_RS03745	COG4615	Cyclic peptide transporter
I6I38_RS03760	COG2807	transmembrane transport
I6I38_RS03765	COG1349	DNA-binding transcription factor activity
I6I38_RS03775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS03780	COG3715	PTS system
I6I38_RS03785	COG3716	PTS system mannose fructose sorbose family IID component
I6I38_RS03795	COG4178	(ABC) transporter
I6I38_RS03815	COG0583	DNA-binding transcription factor activity
I6I38_RS03820	COG2814	Major facilitator Superfamily
I6I38_RS03825	COG0583	DNA-binding transcription factor activity
I6I38_RS03845	COG1609	Transcriptional regulator
I6I38_RS03855	COG1609	Transcriptional regulator
I6I38_RS03865	COG0318	PFAM AMP-dependent synthetase and ligase
I6I38_RS03865	COG0204	Acyl-transferase
I6I38_RS03870	COG0477	Major facilitator Superfamily
I6I38_RS03875	COG0667	Aldo Keto reductase
I6I38_RS03885	COG0861	Integral membrane protein TerC family
I6I38_RS03890	COG3066	DNA modification
I6I38_RS03895	COG0494	nUDIX hydrolase
I6I38_RS03905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I38_RS03910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I38_RS03935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I38_RS03940	COG1025	Belongs to the peptidase M16 family
I6I38_RS03945	COG1074	ATP-dependent DNA helicase activity
I6I38_RS03950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I38_RS03955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I38_RS03955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I38_RS03960	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I38_RS03965	COG2271	Major facilitator Superfamily
I6I38_RS03985	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6I38_RS03990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I38_RS03995	COG2166	iron-sulfur cluster assembly
I6I38_RS04000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I38_RS04010	COG0583	DNA-binding transcription factor activity
I6I38_RS04015	COG2363	Small membrane protein
I6I38_RS04020	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6I38_RS04025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I38_RS04030	COG1611	Belongs to the LOG family
I6I38_RS04040	COG2814	Major facilitator Superfamily
I6I38_RS04045	COG3098	single-species biofilm formation
I6I38_RS04050	COG2373	Large extracellular alpha-helical protein
I6I38_RS04055	COG4953	penicillin-binding protein 1C
I6I38_RS04060	COG0564	pseudouridine synthase activity
I6I38_RS04080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I38_RS04090	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I38_RS04095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I38_RS04100	COG0528	UMP kinase activity
I6I38_RS04105	COG0233	cytoplasmic translational termination
I6I38_RS04110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I38_RS04115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I38_RS04120	COG0575	Belongs to the CDS family
I6I38_RS04125	COG0750	zinc metalloprotease
I6I38_RS04130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I38_RS04135	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6I38_RS04140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I38_RS04145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I38_RS04150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I38_RS04155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I38_RS04160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I38_RS04170	COG0825	malonyl-CoA metabolic process
I6I38_RS04175	COG1982	Orn Lys Arg decarboxylase major
I6I38_RS04190	COG0346	lactoylglutathione lyase activity
I6I38_RS04195	COG3710	Transcriptional regulator
I6I38_RS04200	COG0531	amino acid
I6I38_RS04210	COG3104	oligopeptide transport
I6I38_RS04215	COG0037	tRNA processing
I6I38_RS04225	COG4568	rho-dependent transcription termination
I6I38_RS04240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I38_RS04245	COG3015	lipoprotein NlpE involved in copper resistance
I6I38_RS04250	COG0442	prolyl-tRNA aminoacylation
I6I38_RS04255	COG1720	tRNA m6t6A37 methyltransferase activity
I6I38_RS04270	COG2011	ABC-type metal ion transport system permease component
I6I38_RS04280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I38_RS04310	COG0477	Major facilitator Superfamily
I6I38_RS04315	COG5544	Lipoprotein
I6I38_RS04320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I38_RS04325	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I38_RS04325	COG1042	CoA-binding domain protein
I6I38_RS04325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I38_RS04330	COG3148	PFAM DTW domain containing protein
I6I38_RS04335	COG3118	belongs to the thioredoxin family
I6I38_RS04340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I38_RS04345	COG2814	Major facilitator Superfamily
I6I38_RS04350	COG1566	PFAM secretion protein HlyD family protein
I6I38_RS04355	COG1538	Outer membrane efflux protein
I6I38_RS04360	COG1846	Transcriptional regulator
I6I38_RS04370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I38_RS04375	COG2814	Major facilitator Superfamily
I6I38_RS04380	COG0583	DNA-binding transcription factor activity
I6I38_RS04385	COG2113	Glycine betaine
I6I38_RS04390	COG2113	Glycine betaine
I6I38_RS04395	COG4176	ABC-type proline glycine betaine transport system permease component
I6I38_RS04400	COG4175	Glycine betaine
I6I38_RS04415	COG3493	citrate carrier protein
I6I38_RS04430	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS04450	COG1780	Probably involved in ribonucleotide reductase function
I6I38_RS04455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I38_RS04460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I38_RS04470	COG4575	ribosome binding
I6I38_RS04490	COG0583	DNA-binding transcription factor activity
I6I38_RS04500	COG2207	Transcriptional regulator
I6I38_RS04500	COG3708	Transcriptional regulator
I6I38_RS04520	COG2840	Smr protein MutS2
I6I38_RS04525	COG2259	Doxx family
I6I38_RS04530	COG2388	GCN5-related N-acetyl-transferase
I6I38_RS04540	COG2226	methyltransferase
I6I38_RS04555	COG3713	MltA-interacting MipA family protein
I6I38_RS04560	COG0583	DNA-binding transcription factor activity
I6I38_RS04575	COG1566	PFAM secretion protein HlyD family protein
I6I38_RS04585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I38_RS04590	COG2867	negative regulation of translational initiation
I6I38_RS04595	COG2914	Belongs to the UPF0125 (RnfH) family
I6I38_RS04605	COG0497	DNA recombination
I6I38_RS04610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I38_RS04615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I38_RS04620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I38_RS04625	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I6I38_RS04640	COG0513	Belongs to the DEAD box helicase family
I6I38_RS04645	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I38_RS04650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I38_RS04670	COG3086	response to oxidative stress
I6I38_RS04680	COG0481	GTPase activity
I6I38_RS04685	COG0681	Belongs to the peptidase S26 family
I6I38_RS04690	COG0571	ribonuclease III activity
I6I38_RS04695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I38_RS04700	COG1381	Involved in DNA repair and RecF pathway recombination
I6I38_RS04705	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I38_RS04710	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I38_RS04715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I38_RS04720	COG2194	sulfuric ester hydrolase activity
I6I38_RS04725	COG1737	Transcriptional regulator
I6I38_RS04730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I38_RS04735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS04735	COG1263	PTS System
I6I38_RS04740	COG0560	Phosphoserine phosphatase
I6I38_RS04745	COG1454	alcohol dehydrogenase
I6I38_RS04760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I38_RS04770	COG2205	protein histidine kinase activity
I6I38_RS04775	COG3170	Tfp pilus assembly protein FimV
I6I38_RS04780	COG2204	response regulator
I6I38_RS04785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I38_RS04785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I38_RS04790	COG0347	Belongs to the P(II) protein family
I6I38_RS04805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I38_RS04810	COG3842	ATPase activity
I6I38_RS04815	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I38_RS04820	COG1177	transmembrane transport
I6I38_RS04825	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS04830	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I38_RS04840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I38_RS04840	COG1017	nitric oxide dioxygenase activity
I6I38_RS04845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I38_RS04850	COG2814	Major facilitator Superfamily
I6I38_RS04855	COG3711	transcriptional antiterminator
I6I38_RS04860	COG3683	transport system, periplasmic component
I6I38_RS04865	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I38_RS04880	COG1959	2 iron, 2 sulfur cluster binding
I6I38_RS04885	COG1104	cysteine desulfurase activity
I6I38_RS04890	COG0822	iron-sulfur transferase activity
I6I38_RS04895	COG0316	Belongs to the HesB IscA family
I6I38_RS04900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I38_RS04905	COG0443	Heat shock 70 kDa protein
I6I38_RS04910	COG0633	Ferredoxin
I6I38_RS04915	COG2975	iron-sulfur cluster assembly
I6I38_RS04920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I38_RS04930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I38_RS04935	COG1757	Na H antiporter
I6I38_RS04940	COG1609	Transcriptional regulator
I6I38_RS04945	COG0105	UTP biosynthetic process
I6I38_RS04950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I38_RS04960	COG1426	Protein conserved in bacteria
I6I38_RS04965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I38_RS04970	COG0124	histidyl-tRNA synthetase
I6I38_RS04975	COG2976	Protein conserved in bacteria
I6I38_RS04980	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I38_RS04985	COG1160	GTP binding
I6I38_RS04995	COG1645	bacterial-type flagellum-dependent swarming motility
I6I38_RS05015	COG2271	Major facilitator Superfamily
I6I38_RS05025	COG1570	exodeoxyribonuclease VII activity
I6I38_RS05030	COG0516	GMP reductase activity
I6I38_RS05030	COG0517	IMP dehydrogenase activity
I6I38_RS05035	COG0519	Catalyzes the synthesis of GMP from XMP
I6I38_RS05035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I38_RS05055	COG1733	regulation of RNA biosynthetic process
I6I38_RS05065	COG0784	Response regulator, receiver
I6I38_RS05065	COG2198	Histidine kinase
I6I38_RS05065	COG2205	protein histidine kinase activity
I6I38_RS05070	COG2197	response regulator
I6I38_RS05100	COG2814	Major facilitator Superfamily
I6I38_RS05105	COG2188	Transcriptional regulator
I6I38_RS05110	COG1082	Xylose isomerase domain protein TIM barrel
I6I38_RS05115	COG2271	Major facilitator Superfamily
I6I38_RS05125	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I38_RS05130	COG0351	phosphomethylpyrimidine kinase
I6I38_RS05150	COG1349	DNA-binding transcription factor activity
I6I38_RS05155	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I38_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS05175	COG3730	PTS system glucitol sorbitol-specific
I6I38_RS05180	COG1830	Aldolase
I6I38_RS05185	COG1802	Transcriptional regulator
I6I38_RS05190	COG0246	Mannitol dehydrogenase
I6I38_RS05195	COG2271	Major facilitator Superfamily
I6I38_RS05200	COG1063	alcohol dehydrogenase
I6I38_RS05205	COG4948	Mandelate Racemase Muconate Lactonizing
I6I38_RS05210	COG1597	lipid kinase activity
I6I38_RS05215	COG0826	peptidase U32
I6I38_RS05220	COG3422	double-strand break repair
I6I38_RS05235	COG0745	RESPONSE REGULATOR receiver
I6I38_RS05240	COG2205	protein histidine kinase activity
I6I38_RS05245	COG2814	Major facilitator Superfamily
I6I38_RS05250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I38_RS05255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I38_RS05260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS05265	COG0667	Aldo Keto reductase
I6I38_RS05275	COG0443	Heat shock 70 kDa protein
I6I38_RS05280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6I38_RS05290	COG3447	MASE1 domain protein
I6I38_RS05290	COG5001	Diguanylate cyclase
I6I38_RS05290	COG5002	protein histidine kinase activity
I6I38_RS05295	COG2239	Acts as a magnesium transporter
I6I38_RS05305	COG2200	EAL domain
I6I38_RS05315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I38_RS05320	COG0573	inorganic phosphate transmembrane transporter activity
I6I38_RS05325	COG0573	inorganic phosphate transmembrane transporter activity
I6I38_RS05335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I38_RS05340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I38_RS05345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I38_RS05350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I38_RS05355	COG2233	PERMEase
I6I38_RS05360	COG2261	transglycosylase associated protein
I6I38_RS05375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I38_RS05380	COG1393	Belongs to the ArsC family
I6I38_RS05385	COG4783	chaperone-mediated protein folding
I6I38_RS05415	COG3585	molybdate ion transport
I6I38_RS05415	COG2005	Transcriptional regulator
I6I38_RS05430	COG0628	permease
I6I38_RS05435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I38_RS05440	COG2716	regulation of RNA biosynthetic process
I6I38_RS05455	COG4974	Belongs to the 'phage' integrase family
I6I38_RS05545	COG4695	Portal protein
I6I38_RS05680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I38_RS05685	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I38_RS05690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I38_RS05695	COG2321	neutral zinc metallopeptidase
I6I38_RS05700	COG1444	tRNA N-acetyltransferase activity
I6I38_RS05705	COG0400	carboxylic ester hydrolase activity
I6I38_RS05715	COG1876	peptidase activity
I6I38_RS05720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I38_RS05725	COG1393	Belongs to the ArsC family
I6I38_RS05740	COG0456	acetyltransferase
I6I38_RS05760	COG4771	TonB-dependent receptor
I6I38_RS05770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I38_RS05780	COG2197	response regulator
I6I38_RS05785	COG3850	Histidine kinase
I6I38_RS05790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I38_RS05790	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I38_RS05795	COG3062	negative regulation of establishment of protein localization
I6I38_RS05800	COG0243	molybdopterin cofactor binding
I6I38_RS05805	COG3043	anaerobic respiration
I6I38_RS05810	COG3005	denitrification pathway
I6I38_RS05815	COG0494	nUDIX hydrolase
I6I38_RS05820	COG2207	Transcriptional regulator
I6I38_RS05820	COG3708	Transcriptional regulator
I6I38_RS05825	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I38_RS05830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I38_RS05835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I38_RS05840	COG3397	chitin binding
I6I38_RS05845	COG0583	DNA-binding transcription factor activity
I6I38_RS05880	COG2040	homocysteine
I6I38_RS05885	COG0833	amino acid
I6I38_RS05900	COG1770	oligopeptidase
I6I38_RS05910	COG1671	Belongs to the UPF0178 family
I6I38_RS05915	COG0408	coproporphyrinogen oxidase activity
I6I38_RS05925	COG0456	acetyltransferase
I6I38_RS05930	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I38_RS05945	COG2837	iron assimilation
I6I38_RS05950	COG4150	thiosulfate binding
I6I38_RS05955	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I38_RS05960	COG4208	sulfate ABC transporter
I6I38_RS05970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I38_RS05975	COG1136	(ABC) transporter
I6I38_RS05975	COG0577	efflux transmembrane transporter activity
I6I38_RS05980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS05985	COG0745	RESPONSE REGULATOR receiver
I6I38_RS05990	COG2205	protein histidine kinase activity
I6I38_RS06000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I38_RS06005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I38_RS06020	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6I38_RS06025	COG3115	cell septum assembly
I6I38_RS06030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I38_RS06035	COG3530	Putative quorum-sensing-regulated virulence factor
I6I38_RS06040	COG0385	Bile acid
I6I38_RS06045	COG0583	DNA-binding transcription factor activity
I6I38_RS06060	COG4303	Ethanolamine ammonia lyase large subunit
I6I38_RS06065	COG4302	ethanolamine ammonia-lyase activity
I6I38_RS06085	COG0747	negative chemotaxis
I6I38_RS06090	COG4771	TonB-dependent receptor
I6I38_RS06095	COG2382	esterase
I6I38_RS06100	COG3251	PFAM MbtH domain protein
I6I38_RS06105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I38_RS06105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I38_RS06110	COG1120	ATPase activity
I6I38_RS06115	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I38_RS06120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I38_RS06130	COG4592	Periplasmic binding protein
I6I38_RS06135	COG1169	isochorismate synthase
I6I38_RS06140	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I38_RS06145	COG3433	isochorismatase activity
I6I38_RS06145	COG1535	isochorismatase
I6I38_RS06150	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS06190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I38_RS06195	COG2116	formate transmembrane transporter activity
I6I38_RS06210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I38_RS06215	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I38_RS06225	COG0667	Aldo Keto reductase
I6I38_RS06230	COG3961	Belongs to the TPP enzyme family
I6I38_RS06245	COG1794	racemase activity, acting on amino acids and derivatives
I6I38_RS06260	COG2223	nitrite transmembrane transporter activity
I6I38_RS06270	COG3279	Response regulator of the LytR AlgR family
I6I38_RS06275	COG3275	phosphorelay sensor kinase activity
I6I38_RS06290	COG0436	Aminotransferase
I6I38_RS06295	COG3038	cytochrome b561
I6I38_RS06310	COG1598	PFAM Uncharacterised protein family UPF0150
I6I38_RS06320	COG2951	lytic endotransglycosylase activity
I6I38_RS06335	COG0697	spore germination
I6I38_RS06345	COG0583	DNA-binding transcription factor activity
I6I38_RS06350	COG3122	Protein conserved in bacteria
I6I38_RS06360	COG2116	formate transmembrane transporter activity
I6I38_RS06370	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I38_RS06375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I38_RS06380	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I38_RS06385	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I38_RS06390	COG1138	Cytochrome C-type biogenesis protein
I6I38_RS06395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I38_RS06400	COG3088	subunit of a heme lyase
I6I38_RS06400	COG4235	cytochrome complex assembly
I6I38_RS06405	COG4235	cytochrome complex assembly
I6I38_RS06405	COG3088	subunit of a heme lyase
I6I38_RS06420	COG3691	Protein conserved in bacteria
I6I38_RS06425	COG0183	Belongs to the thiolase family
I6I38_RS06430	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I38_RS06430	COG1024	Enoyl-CoA hydratase
I6I38_RS06435	COG2062	phosphohistidine phosphatase, SixA
I6I38_RS06440	COG2840	Smr protein MutS2
I6I38_RS06445	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I38_RS06450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I38_RS06455	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6I38_RS06460	COG0730	response to heat
I6I38_RS06465	COG3101	peptidyl-lysine hydroxylation
I6I38_RS06475	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I38_RS06475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I38_RS06480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I38_RS06505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS06510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I38_RS06515	COG1477	protein flavinylation
I6I38_RS06520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I38_RS06525	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I38_RS06565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I38_RS06570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I38_RS06610	COG0642	Histidine kinase
I6I38_RS06615	COG0697	spore germination
I6I38_RS06625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I38_RS06630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I38_RS06640	COG0586	Pfam SNARE associated Golgi protein
I6I38_RS06645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I38_RS06650	COG0285	dihydrofolate synthase activity
I6I38_RS06655	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6I38_RS06660	COG1286	toxin biosynthetic process
I6I38_RS06665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I38_RS06670	COG0163	prenyltransferase activity
I6I38_RS06675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS06680	COG4215	(ABC) transporter
I6I38_RS06690	COG4598	ABC transporter
I6I38_RS06695	COG1090	epimerase
I6I38_RS06700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I38_RS06705	COG0625	glutathione transferase activity
I6I38_RS06710	COG0622	Phosphoesterase
I6I38_RS06715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I38_RS06720	COG0857	belongs to the CobB CobQ family
I6I38_RS06720	COG0280	phosphate acetyltransferase
I6I38_RS06725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I38_RS06730	COG3092	negative regulation of chromosome organization
I6I38_RS06735	COG3013	Belongs to the UPF0304 family
I6I38_RS06740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I38_RS06745	COG0471	metal ion transport
I6I38_RS06745	COG0490	domain, Protein
I6I38_RS06750	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6I38_RS06755	COG0436	Aminotransferase
I6I38_RS06760	COG0583	DNA-binding transcription factor activity
I6I38_RS06765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I38_RS06770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I38_RS06775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I38_RS06775	COG0649	NAD binding
I6I38_RS06790	COG1034	ATP synthesis coupled electron transport
I6I38_RS06795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I38_RS06805	COG0839	Belongs to the complex I subunit 6 family
I6I38_RS06810	COG0713	ATP synthesis coupled electron transport
I6I38_RS06815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I38_RS06820	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I38_RS06825	COG1007	ATP synthesis coupled electron transport
I6I38_RS06845	COG0028	Belongs to the TPP enzyme family
I6I38_RS06870	COG1609	Transcriptional regulator
I6I38_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS06880	COG1063	alcohol dehydrogenase
I6I38_RS06885	COG4575	ribosome binding
I6I38_RS06890	COG3459	Glycosyltransferase 36 associated
I6I38_RS06895	COG1169	isochorismate synthase
I6I38_RS06900	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I38_RS06905	COG0596	Alpha beta hydrolase
I6I38_RS06910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I38_RS06935	COG0814	amino acid
I6I38_RS06945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I38_RS06950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I38_RS06960	COG2721	sulfolactate sulfo-lyase activity
I6I38_RS06970	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS06975	COG1063	alcohol dehydrogenase
I6I38_RS06980	COG2271	Major facilitator Superfamily
I6I38_RS06985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I38_RS06985	COG0473	3-isopropylmalate dehydrogenase activity
I6I38_RS06995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I38_RS07005	COG2205	protein histidine kinase activity
I6I38_RS07005	COG0784	Response regulator, receiver
I6I38_RS07015	COG0642	Histidine kinase
I6I38_RS07015	COG2198	Histidine kinase
I6I38_RS07020	COG2223	nitrite transmembrane transporter activity
I6I38_RS07035	COG0346	lactoylglutathione lyase activity
I6I38_RS07070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I38_RS07085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I38_RS07085	COG2755	lipolytic protein G-D-S-L family
I6I38_RS07100	COG3082	Protein of unknown function (DUF1414)
I6I38_RS07105	COG3081	Nucleoid-associated protein
I6I38_RS07110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I38_RS07115	COG1061	Type III restriction enzyme res subunit
I6I38_RS07120	COG1187	pseudouridine synthase activity
I6I38_RS07125	COG2814	Major facilitator Superfamily
I6I38_RS07135	COG4172	Belongs to the ABC transporter superfamily
I6I38_RS07140	COG4239	(ABC) transporter, permease
I6I38_RS07145	COG4174	ABC transporter (Permease)
I6I38_RS07150	COG4166	transmembrane transport
I6I38_RS07155	COG2200	EAL domain
I6I38_RS07160	COG0791	NLP P60 protein
I6I38_RS07165	COG0671	phosphoesterase, PA-phosphatase related
I6I38_RS07170	COG0523	cobalamin synthesis protein
I6I38_RS07180	COG0246	Mannitol dehydrogenase
I6I38_RS07185	COG1312	Catalyzes the dehydration of D-mannonate
I6I38_RS07190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I38_RS07210	COG0243	molybdopterin cofactor binding
I6I38_RS07215	COG3005	denitrification pathway
I6I38_RS07220	COG0494	nUDIX hydrolase
I6I38_RS07230	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I38_RS07235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I38_RS07235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I38_RS07235	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I38_RS07240	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I38_RS07245	COG2855	membrane
I6I38_RS07250	COG0583	DNA-binding transcription factor activity
I6I38_RS07255	COG0833	amino acid
I6I38_RS07265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I38_RS07280	COG4771	TonB-dependent receptor
I6I38_RS07285	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS07290	COG1129	ABC transporter
I6I38_RS07295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I38_RS07300	COG1917	Cupin 2, conserved barrel domain protein
I6I38_RS07300	COG1396	sequence-specific DNA binding
I6I38_RS07305	COG0174	glutamine synthetase
I6I38_RS07310	COG0531	amino acid
I6I38_RS07315	COG2925	Exonuclease
I6I38_RS07340	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I38_RS07345	COG1289	transmembrane transporter activity
I6I38_RS07350	COG2926	Belongs to the UPF0265 family
I6I38_RS07355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS07360	COG1473	amidohydrolase
I6I38_RS07375	COG1349	DNA-binding transcription factor activity
I6I38_RS07385	COG1129	ABC transporter
I6I38_RS07390	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS07395	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS07400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I38_RS07405	COG1940	carbohydrate kinase activity
I6I38_RS07410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS07435	COG0411	ABC transporter
I6I38_RS07450	COG1609	Transcriptional regulator
I6I38_RS07455	COG0673	inositol 2-dehydrogenase activity
I6I38_RS07460	COG1082	Xylose isomerase domain protein TIM barrel
I6I38_RS07470	COG2271	Major facilitator Superfamily
I6I38_RS07475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6I38_RS07555	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I6I38_RS07565	COG3504	Conjugal transfer protein
I6I38_RS07570	COG3736	Type IV secretory pathway, component VirB8
I6I38_RS07595	COG3451	type IV secretory pathway VirB4
I6I38_RS07615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I38_RS07630	COG2207	Transcriptional regulator
I6I38_RS07645	COG1566	PFAM secretion protein HlyD family protein
I6I38_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS07680	COG1737	Transcriptional regulator
I6I38_RS07695	COG0582	viral genome integration into host DNA
I6I38_RS07700	COG0583	DNA-binding transcription factor activity
I6I38_RS07705	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS07715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I38_RS07720	COG2072	flavoprotein involved in K transport
I6I38_RS07780	COG0604	alcohol dehydrogenase
I6I38_RS07780	COG3321	synthase
I6I38_RS07795	COG0583	DNA-binding transcription factor activity
I6I38_RS07840	COG0667	Aldo Keto reductase
I6I38_RS07845	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I38_RS07850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I38_RS07855	COG1733	regulation of RNA biosynthetic process
I6I38_RS07870	COG2807	transmembrane transport
I6I38_RS07875	COG2207	Transcriptional regulator
I6I38_RS07885	COG0582	viral genome integration into host DNA
I6I38_RS07895	COG3250	beta-galactosidase activity
I6I38_RS07900	COG4565	transcriptional regulatory protein
I6I38_RS07905	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6I38_RS07910	COG3052	prosthetic group binding
I6I38_RS07915	COG2301	Belongs to the HpcH HpaI aldolase family
I6I38_RS07920	COG3051	citrate lyase alpha subunit
I6I38_RS07935	COG0471	metal ion transport
I6I38_RS07945	COG2977	Belongs to the P-Pant transferase superfamily
I6I38_RS07965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I38_RS07975	COG0747	negative chemotaxis
I6I38_RS07980	COG0601	transmembrane transport
I6I38_RS07985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I38_RS07990	COG4172	Belongs to the ABC transporter superfamily
I6I38_RS07995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS08015	COG0859	PFAM glycosyl transferase family 9
I6I38_RS08025	COG0583	DNA-binding transcription factor activity
I6I38_RS08050	COG3238	Protein conserved in bacteria
I6I38_RS08060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I38_RS08065	COG0583	DNA-binding transcription factor activity
I6I38_RS08100	COG0642	Histidine kinase
I6I38_RS08110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS08125	COG3781	membrane
I6I38_RS08130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I38_RS08145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I38_RS08150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I38_RS08155	COG1116	anion transmembrane transporter activity
I6I38_RS08160	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I38_RS08165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS08170	COG4977	sequence-specific DNA binding
I6I38_RS08175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I38_RS08185	COG3842	ATPase activity
I6I38_RS08195	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I38_RS08200	COG1609	Transcriptional regulator
I6I38_RS08230	COG0583	DNA-binding transcription factor activity
I6I38_RS08235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I38_RS08245	COG3228	Belongs to the MtfA family
I6I38_RS08255	COG4977	sequence-specific DNA binding
I6I38_RS08260	COG1335	isochorismatase
I6I38_RS08295	COG0795	lipopolysaccharide-transporting ATPase activity
I6I38_RS08300	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6I38_RS08310	COG2244	polysaccharide biosynthetic process
I6I38_RS08315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I38_RS08320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I38_RS08325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I38_RS08330	COG0156	8-amino-7-oxononanoate synthase activity
I6I38_RS08335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I38_RS08350	COG0456	acetyltransferase
I6I38_RS08360	COG0534	Mate efflux family protein
I6I38_RS08370	COG1486	melibiose metabolic process
I6I38_RS08375	COG2223	nitrite transmembrane transporter activity
I6I38_RS08385	COG4993	Dehydrogenase
I6I38_RS08390	COG0667	Aldo Keto reductase
I6I38_RS08420	COG0625	glutathione transferase activity
I6I38_RS08425	COG0583	DNA-binding transcription factor activity
I6I38_RS08445	COG1113	amino acid transport
I6I38_RS08450	COG0697	spore germination
I6I38_RS08460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I38_RS08465	COG3327	negative regulation of DNA-templated transcription, initiation
I6I38_RS08470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6I38_RS08475	COG0183	Belongs to the thiolase family
I6I38_RS08480	COG2050	protein possibly involved in aromatic compounds catabolism
I6I38_RS08485	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I38_RS08490	COG1024	Enoyl-CoA hydratase
I6I38_RS08495	COG1024	Enoyl-CoA hydratase
I6I38_RS08500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I38_RS08505	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I38_RS08510	COG3396	Phenylacetate-CoA oxygenase
I6I38_RS08515	COG3460	Phenylacetate-CoA oxygenase
I6I38_RS08520	COG3396	Phenylacetate-CoA oxygenase
I6I38_RS08525	COG2030	dehydratase
I6I38_RS08525	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS08530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I38_RS08540	COG2203	Gaf domain
I6I38_RS08540	COG5001	Diguanylate cyclase
I6I38_RS08540	COG3706	GGDEF domain
I6I38_RS08540	COG4251	negative regulation of phosphorylation
I6I38_RS08550	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6I38_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS08560	COG0583	DNA-binding transcription factor activity
I6I38_RS08565	COG2261	transglycosylase associated protein
I6I38_RS08570	COG3753	Protein conserved in bacteria
I6I38_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS08590	COG0604	alcohol dehydrogenase
I6I38_RS08590	COG3321	synthase
I6I38_RS08605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I38_RS08625	COG0076	glutamate decarboxylase activity
I6I38_RS08635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I38_RS08645	COG1285	pathogenesis
I6I38_RS08690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I38_RS08700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I38_RS08705	COG0183	Belongs to the thiolase family
I6I38_RS08710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I38_RS08720	COG1414	Transcriptional regulator
I6I38_RS08725	COG2837	iron assimilation
I6I38_RS08750	COG0156	8-amino-7-oxononanoate synthase activity
I6I38_RS08760	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6I38_RS08765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I38_RS08780	COG3483	tryptophan 2,3-dioxygenase activity
I6I38_RS08785	COG0583	DNA-binding transcription factor activity
I6I38_RS08790	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I38_RS08795	COG2130	NADP-dependent
I6I38_RS08830	COG0643	Histidine kinase
I6I38_RS08830	COG2198	Histidine kinase
I6I38_RS08835	COG0835	chemotaxis
I6I38_RS08840	COG0840	transmembrane signaling receptor activity
I6I38_RS08845	COG0840	transmembrane signaling receptor activity
I6I38_RS08850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I38_RS08860	COG0745	RESPONSE REGULATOR receiver
I6I38_RS08865	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I38_RS08870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I38_RS08875	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I38_RS08885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I38_RS08895	COG3418	PFAM FlgN family protein
I6I38_RS08900	COG2747	anti-sigma28 factor FlgM
I6I38_RS08910	COG1815	bacterial-type flagellum-dependent cell motility
I6I38_RS08915	COG1558	bacterial-type flagellum-dependent cell motility
I6I38_RS08920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I38_RS08955	COG1256	bacterial-type flagellum assembly
I6I38_RS08975	COG1987	bacterial-type flagellum assembly
I6I38_RS09000	COG1580	Controls the rotational direction of flagella during chemotaxis
I6I38_RS09010	COG2882	bacterial-type flagellum organization
I6I38_RS09015	COG1157	protein secretion by the type III secretion system
I6I38_RS09020	COG1317	bacterial-type flagellum organization
I6I38_RS09025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I38_RS09035	COG1677	Flagellar hook-basal body complex protein FliE
I6I38_RS09055	COG1609	Transcriptional regulator
I6I38_RS09090	COG1191	sigma factor activity
I6I38_RS09100	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I38_RS09105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS09110	COG0765	amino acid transport
I6I38_RS09115	COG1126	abc transporter atp-binding protein
I6I38_RS09130	COG0506	proline dehydrogenase activity
I6I38_RS09130	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I38_RS09130	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I38_RS09140	COG0672	)-iron permease
I6I38_RS09145	COG2822	iron ion transport
I6I38_RS09155	COG4772	TonB-dependent receptor
I6I38_RS09160	COG1702	phosphate starvation-inducible protein PhoH
I6I38_RS09165	COG3302	dmso reductase anchor subunit
I6I38_RS09170	COG0437	4 iron, 4 sulfur cluster binding
I6I38_RS09175	COG0243	molybdopterin cofactor binding
I6I38_RS09185	COG0387	Pfam Sodium calcium exchanger
I6I38_RS09195	COG4572	Cation transport regulator
I6I38_RS09200	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6I38_RS09205	COG0583	DNA-binding transcription factor activity
I6I38_RS09215	COG4166	transmembrane transport
I6I38_RS09220	COG0601	transmembrane transport
I6I38_RS09225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I38_RS09230	COG0444	Belongs to the ABC transporter superfamily
I6I38_RS09235	COG4608	Belongs to the ABC transporter superfamily
I6I38_RS09255	COG4932	domain protein
I6I38_RS09260	COG2197	response regulator
I6I38_RS09265	COG3850	Histidine kinase
I6I38_RS09270	COG2223	nitrite transmembrane transporter activity
I6I38_RS09275	COG3710	Transcriptional regulator
I6I38_RS09280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I38_RS09285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I38_RS09295	COG0489	protein tyrosine kinase activity
I6I38_RS09295	COG3206	protein involved in exopolysaccharide biosynthesis
I6I38_RS09330	COG1216	Glycosyl transferase, family 2
I6I38_RS09335	COG1216	Glycosyl transferase, family 2
I6I38_RS09335	COG0463	Glycosyl transferase, family 2
I6I38_RS09345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I38_RS09350	COG1140	nitrate reductase beta subunit
I6I38_RS09355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6I38_RS09360	COG2181	nitrate reductase activity
I6I38_RS09365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I38_RS09370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I38_RS09420	COG1294	oxidase, subunit
I6I38_RS09425	COG1271	oxidase subunit
I6I38_RS09430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I38_RS09440	COG0601	transmembrane transport
I6I38_RS09450	COG0444	Belongs to the ABC transporter superfamily
I6I38_RS09455	COG4608	Belongs to the ABC transporter superfamily
I6I38_RS09470	COG1609	Transcriptional regulator
I6I38_RS09475	COG3842	ATPase activity
I6I38_RS09480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I38_RS09485	COG0395	ABC-type sugar transport system, permease component
I6I38_RS09490	COG1175	transmembrane transport
I6I38_RS09500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I38_RS09505	COG3138	arginine N-succinyltransferase
I6I38_RS09510	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS09515	COG3724	N-succinylarginine dihydrolase activity
I6I38_RS09520	COG2988	succinylglutamate desuccinylase activity
I6I38_RS09540	COG1652	LysM domain
I6I38_RS09560	COG2207	Transcriptional regulator
I6I38_RS09605	COG1113	amino acid transport
I6I38_RS09635	COG2226	methyltransferase
I6I38_RS09640	COG1971	Probably functions as a manganese efflux pump
I6I38_RS09645	COG4811	Protein of unknown function (DUF986)
I6I38_RS09650	COG3716	PTS system mannose fructose sorbose family IID component
I6I38_RS09655	COG3715	PTS system
I6I38_RS09660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I38_RS09660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS09665	COG1253	flavin adenine dinucleotide binding
I6I38_RS09670	COG2200	EAL domain
I6I38_RS09675	COG1760	l-serine dehydratase
I6I38_RS09680	COG0494	nUDIX hydrolase
I6I38_RS09685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I38_RS09690	COG1216	Glycosyl transferase, family 2
I6I38_RS09695	COG3140	Belongs to the UPF0181 family
I6I38_RS09700	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I38_RS09705	COG0513	Belongs to the DEAD box helicase family
I6I38_RS09710	COG3141	response to X-ray
I6I38_RS09715	COG3097	Belongs to the UPF0267 family
I6I38_RS09735	COG2999	glutathione oxidoreductase activity
I6I38_RS09745	COG0477	Major facilitator Superfamily
I6I38_RS09750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I38_RS09755	COG3132	Protein of unknown function, DUF480
I6I38_RS09770	COG0018	arginyl-trna synthetase
I6I38_RS09775	COG3102	Protein conserved in bacteria
I6I38_RS09780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I38_RS09785	COG3142	Participates in the control of copper homeostasis
I6I38_RS09795	COG0500	methyltransferase
I6I38_RS09800	COG2226	methyltransferase
I6I38_RS09805	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6I38_RS09810	COG1801	Protein of unknown function DUF72
I6I38_RS09815	COG1335	isochorismatase
I6I38_RS09825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I38_RS09830	COG0494	nUDIX hydrolase
I6I38_RS09835	COG0217	transcriptional regulatory protein
I6I38_RS09840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I38_RS09845	COG0632	four-way junction helicase activity
I6I38_RS09850	COG2255	four-way junction helicase activity
I6I38_RS09855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I38_RS09860	COG1121	(ABC) transporter
I6I38_RS09865	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6I38_RS09870	COG0739	heme binding
I6I38_RS09875	COG1560	Kdo2-lipid A biosynthetic process
I6I38_RS09885	COG0469	pyruvate kinase activity
I6I38_RS09890	COG1737	Transcriptional regulator
I6I38_RS09895	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I38_RS09900	COG0800	Aldolase
I6I38_RS09905	COG2076	Multidrug Resistance protein
I6I38_RS09910	COG2076	Multidrug Resistance protein
I6I38_RS09915	COG0251	oxidation-reduction process
I6I38_RS09920	COG1199	ATP-dependent helicase activity
I6I38_RS09930	COG3065	identical protein binding
I6I38_RS09935	COG0318	PFAM AMP-dependent synthetase and ligase
I6I38_RS09940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I38_RS09945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I38_RS09950	COG2894	cell division
I6I38_RS09955	COG0850	regulation of cytokinetic process
I6I38_RS09960	COG3100	YcgL domain-containing protein
I6I38_RS09965	COG2951	lytic endotransglycosylase activity
I6I38_RS09970	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I38_RS09980	COG2983	Belongs to the UPF0260 family
I6I38_RS09985	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I38_RS09990	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I38_RS09995	COG2186	Transcriptional regulator
I6I38_RS10005	COG2719	SpoVR family
I6I38_RS10010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I38_RS10015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I38_RS10045	COG0444	Belongs to the ABC transporter superfamily
I6I38_RS10060	COG4774	siderophore transport
I6I38_RS10070	COG0401	homolog of Blt101
I6I38_RS10095	COG2718	Belongs to the UPF0229 family
I6I38_RS10100	COG2766	serine protein kinase
I6I38_RS10110	COG3713	MltA-interacting MipA family protein
I6I38_RS10120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I38_RS10125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I38_RS10130	COG3139	Protein of unknown function (DUF1315)
I6I38_RS10140	COG1335	isochorismatase
I6I38_RS10145	COG0252	asparaginase activity
I6I38_RS10150	COG0616	signal peptide processing
I6I38_RS10155	COG0778	Nitroreductase
I6I38_RS10165	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6I38_RS10170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I38_RS10180	COG0494	nUDIX hydrolase
I6I38_RS10185	COG0708	Exodeoxyribonuclease III
I6I38_RS10235	COG0788	formyltetrahydrofolate deformylase activity
I6I38_RS10240	COG3012	SEC-C Motif Domain Protein
I6I38_RS10245	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I38_RS10250	COG0745	RESPONSE REGULATOR receiver
I6I38_RS10255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I38_RS10280	COG1454	alcohol dehydrogenase
I6I38_RS10280	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS10285	COG2095	MarC family integral membrane protein
I6I38_RS10305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I38_RS10310	COG0444	Belongs to the ABC transporter superfamily
I6I38_RS10335	COG3192	ethanolamine utilization protein
I6I38_RS10340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I38_RS10350	COG3099	Belongs to the UPF0263 family
I6I38_RS10355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I38_RS10365	COG0783	Belongs to the Dps family
I6I38_RS10390	COG2350	Protein conserved in bacteria
I6I38_RS10395	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I38_RS10415	COG1609	Transcriptional regulator
I6I38_RS10420	COG1607	acyl-coa hydrolase
I6I38_RS10425	COG2917	probably involved in intracellular septation
I6I38_RS10440	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6I38_RS10445	COG3047	cAMP biosynthetic process
I6I38_RS10455	COG0159	tryptophan synthase activity
I6I38_RS10460	COG0133	tryptophan synthase activity
I6I38_RS10480	COG0613	PHP domain protein
I6I38_RS10485	COG0009	L-threonylcarbamoyladenylate synthase
I6I38_RS10500	COG1187	pseudouridine synthase activity
I6I38_RS10505	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6I38_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS10515	COG0616	signal peptide processing
I6I38_RS10530	COG0583	DNA-binding transcription factor activity
I6I38_RS10545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I38_RS10555	COG0671	phosphoesterase, PA-phosphatase related
I6I38_RS10560	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6I38_RS10565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I38_RS10585	COG0023	Translation Initiation Factor
I6I38_RS10595	COG0235	Class ii aldolase
I6I38_RS10600	COG1349	DNA-binding transcription factor activity
I6I38_RS10605	COG1882	Formate acetyltransferase
I6I38_RS10610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I38_RS10615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I38_RS10620	COG1966	Carbon starvation protein
I6I38_RS10625	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6I38_RS10640	COG0243	molybdopterin cofactor binding
I6I38_RS10650	COG0583	DNA-binding transcription factor activity
I6I38_RS10655	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I38_RS10655	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I38_RS10670	COG4171	peptide transport system, permease
I6I38_RS10685	COG1469	GTP cyclohydrolase I activity
I6I38_RS10700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6I38_RS10705	COG1842	Phage shock protein A
I6I38_RS10715	COG1983	PspC domain protein
I6I38_RS10725	COG3106	COG3106 Predicted ATPase
I6I38_RS10730	COG3768	UPF0283 membrane protein
I6I38_RS10740	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I38_RS10745	COG4948	Mandelate Racemase Muconate Lactonizing
I6I38_RS10750	COG2866	Carboxypeptidase
I6I38_RS10760	COG4166	transmembrane transport
I6I38_RS10785	COG0037	tRNA processing
I6I38_RS10800	COG0789	Transcriptional regulator
I6I38_RS10825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS10830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I38_RS10830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I38_RS10830	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I38_RS10830	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I38_RS10840	COG3042	response to heat
I6I38_RS10845	COG3187	Heat shock protein
I6I38_RS10850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I38_RS10855	COG2911	Protein conserved in bacteria
I6I38_RS10865	COG3784	Protein of unknown function (DUF1318)
I6I38_RS10875	COG1643	Atp-dependent helicase
I6I38_RS10885	COG3591	Belongs to the peptidase S1B family
I6I38_RS10895	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6I38_RS10900	COG2205	protein histidine kinase activity
I6I38_RS10905	COG0745	RESPONSE REGULATOR receiver
I6I38_RS10910	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS10920	COG0531	amino acid
I6I38_RS10930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6I38_RS10935	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6I38_RS10940	COG0589	response to stress
I6I38_RS10960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I38_RS10975	COG2222	sugar isomerase
I6I38_RS10980	COG1349	DNA-binding transcription factor activity
I6I38_RS10985	COG1940	carbohydrate kinase activity
I6I38_RS10995	COG3842	ATPase activity
I6I38_RS11000	COG0395	ABC-type sugar transport system, permease component
I6I38_RS11005	COG1175	transmembrane transport
I6I38_RS11030	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6I38_RS11035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6I38_RS11055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS11070	COG0306	phosphate transporter
I6I38_RS11130	COG3158	transport of potassium into the cell
I6I38_RS11140	COG1309	transcriptional regulator
I6I38_RS11170	COG0697	spore germination
I6I38_RS11175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I38_RS11200	COG2239	Acts as a magnesium transporter
I6I38_RS11225	COG0488	(ABC) transporter
I6I38_RS11230	COG1511	domain protein
I6I38_RS11230	COG3264	Mechanosensitive ion channel
I6I38_RS11235	COG1054	Belongs to the UPF0176 family
I6I38_RS11245	COG1263	PTS System
I6I38_RS11245	COG2190	(PTS) system
I6I38_RS11245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS11250	COG0583	DNA-binding transcription factor activity
I6I38_RS11255	COG1653	transport
I6I38_RS11275	COG3842	ATPase activity
I6I38_RS11280	COG0366	Alpha amylase catalytic
I6I38_RS11290	COG2199	diguanylate cyclase activity
I6I38_RS11295	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6I38_RS11305	COG3048	D-serine ammonia-lyase activity
I6I38_RS11310	COG1414	Transcriptional regulator
I6I38_RS11330	COG2814	Major facilitator Superfamily
I6I38_RS11340	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS11350	COG3962	Belongs to the TPP enzyme family
I6I38_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS11375	COG0673	inositol 2-dehydrogenase activity
I6I38_RS11385	COG1879	ABC-type sugar transport system periplasmic component
I6I38_RS11395	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I38_RS11400	COG0583	DNA-binding transcription factor activity
I6I38_RS11405	COG3485	protocatechuate 3,4-dioxygenase
I6I38_RS11410	COG3485	protocatechuate 3,4-dioxygenase
I6I38_RS11415	COG2723	6-phospho-beta-galactosidase activity
I6I38_RS11420	COG1737	Transcriptional regulator
I6I38_RS11425	COG2271	Major facilitator Superfamily
I6I38_RS11430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I38_RS11435	COG2080	2 iron, 2 sulfur cluster binding
I6I38_RS11440	COG2010	Cytochrome c
I6I38_RS11440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I38_RS11455	COG1396	sequence-specific DNA binding
I6I38_RS11485	COG0582	viral genome integration into host DNA
I6I38_RS11495	COG0583	DNA-binding transcription factor activity
I6I38_RS11500	COG2957	Belongs to the agmatine deiminase family
I6I38_RS11525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I38_RS11540	COG0693	protein deglycase activity
I6I38_RS11545	COG0318	PFAM AMP-dependent synthetase and ligase
I6I38_RS11550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I38_RS11555	COG1113	amino acid transport
I6I38_RS11570	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS11580	COG0583	DNA-binding transcription factor activity
I6I38_RS11595	COG0583	DNA-binding transcription factor activity
I6I38_RS11600	COG2610	gluconate transmembrane transporter activity
I6I38_RS11605	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I38_RS11605	COG1902	pentaerythritol trinitrate reductase activity
I6I38_RS11610	COG0789	Transcriptional regulator
I6I38_RS11640	COG2197	response regulator
I6I38_RS11665	COG0309	Hydrogenase expression formation protein (HypE)
I6I38_RS11670	COG0409	Hydrogenase expression formation protein
I6I38_RS11675	COG0298	carbon dioxide binding
I6I38_RS11680	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I38_RS11685	COG0375	protein maturation
I6I38_RS11695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I38_RS11700	COG0651	ATP synthesis coupled electron transport
I6I38_RS11705	COG0650	Formate hydrogenlyase subunit 4
I6I38_RS11710	COG3261	NADH dehydrogenase
I6I38_RS11710	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6I38_RS11715	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I38_RS11720	COG3260	NADH ubiquinone oxidoreductase 20
I6I38_RS11730	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6I38_RS11735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I38_RS11740	COG3383	formate dehydrogenase (NAD+) activity
I6I38_RS11745	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6I38_RS11750	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I38_RS11765	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS11770	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I38_RS11775	COG1802	Transcriptional regulator
I6I38_RS11810	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS11815	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I38_RS11825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I38_RS11830	COG0076	glutamate decarboxylase activity
I6I38_RS11855	COG0583	DNA-binding transcription factor activity
I6I38_RS11860	COG4993	Dehydrogenase
I6I38_RS11880	COG3284	Transcriptional regulator
I6I38_RS11890	COG1064	alcohol dehydrogenase
I6I38_RS11915	COG1522	sequence-specific DNA binding
I6I38_RS11940	COG0583	DNA-binding transcription factor activity
I6I38_RS11945	COG2814	Major facilitator Superfamily
I6I38_RS11960	COG0673	inositol 2-dehydrogenase activity
I6I38_RS11975	COG4558	Periplasmic binding protein
I6I38_RS11990	COG2862	Uncharacterized protein family, UPF0114
I6I38_RS12010	COG0371	Dehydrogenase
I6I38_RS12030	COG2814	Major facilitator Superfamily
I6I38_RS12040	COG2814	Major facilitator Superfamily
I6I38_RS12050	COG0583	DNA-binding transcription factor activity
I6I38_RS12055	COG2079	MmgE PrpD family protein
I6I38_RS12060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS12070	COG0765	amino acid transport
I6I38_RS12075	COG1126	abc transporter atp-binding protein
I6I38_RS12090	COG0768	penicillin binding
I6I38_RS12110	COG4608	Belongs to the ABC transporter superfamily
I6I38_RS12115	COG0444	Belongs to the ABC transporter superfamily
I6I38_RS12120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I38_RS12125	COG0601	transmembrane transport
I6I38_RS12130	COG0747	negative chemotaxis
I6I38_RS12135	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6I38_RS12150	COG2814	Major facilitator Superfamily
I6I38_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS12210	COG0596	Alpha beta hydrolase
I6I38_RS12245	COG2723	6-phospho-beta-galactosidase activity
I6I38_RS12250	COG2190	(PTS) system
I6I38_RS12250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS12250	COG1263	PTS System
I6I38_RS12255	COG2140	Oxalate decarboxylase
I6I38_RS12260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I38_RS12260	COG2010	Cytochrome c
I6I38_RS12275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I38_RS12295	COG0583	DNA-binding transcription factor activity
I6I38_RS12300	COG2010	Cytochrome c
I6I38_RS12300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I38_RS12305	COG2080	2 iron, 2 sulfur cluster binding
I6I38_RS12310	COG1846	Transcriptional regulator
I6I38_RS12315	COG2309	aminopeptidase activity
I6I38_RS12320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I38_RS12325	COG0596	Alpha beta hydrolase
I6I38_RS12330	COG3473	Maleate cis-trans isomerase
I6I38_RS12335	COG1335	isochorismatase
I6I38_RS12340	COG2271	Major facilitator Superfamily
I6I38_RS12345	COG0339	signal peptide processing
I6I38_RS12355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I38_RS12365	COG0402	S-adenosylhomocysteine deaminase activity
I6I38_RS12370	COG1940	carbohydrate kinase activity
I6I38_RS12375	COG2182	Extracellular solute-binding protein
I6I38_RS12390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS12395	COG3842	ATPase activity
I6I38_RS12400	COG1595	DNA-templated transcription, initiation
I6I38_RS12405	COG3712	iron ion homeostasis
I6I38_RS12410	COG4772	TonB-dependent receptor
I6I38_RS12415	COG0477	Major facilitator Superfamily
I6I38_RS12425	COG4221	oxidoreductase activity
I6I38_RS12430	COG1742	UPF0060 membrane protein
I6I38_RS12445	COG0477	Major facilitator Superfamily
I6I38_RS12455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I38_RS12460	COG1940	carbohydrate kinase activity
I6I38_RS12465	COG0583	DNA-binding transcription factor activity
I6I38_RS12470	COG2814	Major facilitator Superfamily
I6I38_RS12485	COG2378	regulation of single-species biofilm formation
I6I38_RS12490	COG0114	fumarate hydratase activity
I6I38_RS12505	COG5339	Protein conserved in bacteria
I6I38_RS12515	COG0583	DNA-binding transcription factor activity
I6I38_RS12525	COG2814	Major facilitator Superfamily
I6I38_RS12540	COG1609	Transcriptional regulator
I6I38_RS12545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS12545	COG1263	PTS System
I6I38_RS12550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I38_RS12560	COG0494	nUDIX hydrolase
I6I38_RS12565	COG1349	DNA-binding transcription factor activity
I6I38_RS12570	COG0205	6-phosphofructokinase activity
I6I38_RS12595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I38_RS12600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I38_RS12605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I38_RS12610	COG0385	Bile acid
I6I38_RS12615	COG0673	inositol 2-dehydrogenase activity
I6I38_RS12625	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS12630	COG1129	ABC transporter
I6I38_RS12635	COG1879	ABC-type sugar transport system periplasmic component
I6I38_RS12640	COG1069	ribulokinase activity
I6I38_RS12645	COG2160	L-arabinose isomerase activity
I6I38_RS12655	COG4657	Part of a membrane complex involved in electron transport
I6I38_RS12660	COG2878	Part of a membrane complex involved in electron transport
I6I38_RS12665	COG4656	Part of a membrane complex involved in electron transport
I6I38_RS12670	COG2207	Transcriptional regulator
I6I38_RS12670	COG3708	Transcriptional regulator
I6I38_RS12680	COG4659	FMN binding
I6I38_RS12690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I38_RS12695	COG3104	oligopeptide transport
I6I38_RS12700	COG1505	serine-type exopeptidase activity
I6I38_RS12705	COG1396	sequence-specific DNA binding
I6I38_RS12710	COG3135	benzoate transporter
I6I38_RS12740	COG1418	mRNA catabolic process
I6I38_RS12760	COG0625	glutathione transferase activity
I6I38_RS12770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I38_RS12775	COG0259	pyridoxamine-phosphate oxidase activity
I6I38_RS12780	COG3895	Periplasmic Protein
I6I38_RS12785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I38_RS12790	COG3133	Outer membrane lipoprotein
I6I38_RS12795	COG1846	Transcriptional regulator
I6I38_RS12805	COG1566	PFAM secretion protein HlyD family protein
I6I38_RS12810	COG1289	transmembrane transporter activity
I6I38_RS12820	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I38_RS12825	COG4989	oxidoreductase activity
I6I38_RS12830	COG3313	Fe-S protein
I6I38_RS12835	COG0583	DNA-binding transcription factor activity
I6I38_RS12840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I38_RS12845	COG2194	sulfuric ester hydrolase activity
I6I38_RS12850	COG1309	transcriptional regulator
I6I38_RS12855	COG1902	pentaerythritol trinitrate reductase activity
I6I38_RS12860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I38_RS12865	COG0346	lactoylglutathione lyase activity
I6I38_RS12875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I38_RS12880	COG0791	NLP P60 protein
I6I38_RS12895	COG1609	Transcriptional regulator
I6I38_RS12900	COG0583	DNA-binding transcription factor activity
I6I38_RS12905	COG2814	Major facilitator Superfamily
I6I38_RS12910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I38_RS12920	COG0307	riboflavin synthase, alpha
I6I38_RS12925	COG0534	Mate efflux family protein
I6I38_RS12950	COG0469	pyruvate kinase activity
I6I38_RS12960	COG1388	LysM domain
I6I38_RS12960	COG1376	ErfK ybiS ycfS ynhG family protein
I6I38_RS12965	COG2166	iron-sulfur cluster assembly
I6I38_RS12970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I38_RS12975	COG0719	Fe-S assembly protein
I6I38_RS12980	COG0396	ATPase activity
I6I38_RS12985	COG0719	Fe-S assembly protein
I6I38_RS12990	COG0316	Belongs to the HesB IscA family
I6I38_RS13000	COG2050	protein possibly involved in aromatic compounds catabolism
I6I38_RS13005	COG0277	FAD linked oxidase domain protein
I6I38_RS13005	COG0247	lactate metabolic process
I6I38_RS13010	COG0628	permease
I6I38_RS13020	COG0574	Belongs to the PEP-utilizing enzyme family
I6I38_RS13020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I38_RS13025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I38_RS13030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I38_RS13035	COG0386	Belongs to the glutathione peroxidase family
I6I38_RS13050	COG3720	iron ion transport
I6I38_RS13055	COG4558	Periplasmic binding protein
I6I38_RS13060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I38_RS13065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I38_RS13080	COG0095	Lipoate-protein ligase
I6I38_RS13085	COG0791	NLP P60 protein
I6I38_RS13090	COG2076	Multidrug Resistance protein
I6I38_RS13095	COG2076	Multidrug Resistance protein
I6I38_RS13100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I38_RS13105	COG0726	polysaccharide deacetylase
I6I38_RS13110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I38_RS13110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I38_RS13115	COG1215	transferase activity, transferring glycosyl groups
I6I38_RS13120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I38_RS13125	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6I38_RS13130	COG0386	Belongs to the glutathione peroxidase family
I6I38_RS13135	COG4139	cobalamin transport
I6I38_RS13145	COG0776	regulation of translation
I6I38_RS13155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I38_RS13165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I38_RS13170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I38_RS13180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I38_RS13210	COG0814	amino acid
I6I38_RS13240	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I38_RS13245	COG1121	(ABC) transporter
I6I38_RS13250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I38_RS13255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I38_RS13265	COG3001	Fructosamine kinase
I6I38_RS13280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I38_RS13285	COG1988	membrane-bound metal-dependent
I6I38_RS13290	COG1823	symporter activity
I6I38_RS13305	COG2188	Transcriptional regulator
I6I38_RS13315	COG2814	Major facilitator Superfamily
I6I38_RS13320	COG0501	Belongs to the peptidase M48B family
I6I38_RS13330	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6I38_RS13335	COG1956	GAF domain-containing protein
I6I38_RS13340	COG2995	paraquat-inducible protein a
I6I38_RS13345	COG3008	intermembrane lipid transfer
I6I38_RS13350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I38_RS13350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6I38_RS13415	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I38_RS13420	COG3493	citrate carrier protein
I6I38_RS13425	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I38_RS13435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I38_RS13440	COG0583	DNA-binding transcription factor activity
I6I38_RS13460	COG2986	histidine ammonia-lyase
I6I38_RS13485	COG2211	Major facilitator Superfamily
I6I38_RS13505	COG0402	S-adenosylhomocysteine deaminase activity
I6I38_RS13515	COG1228	amidohydrolase
I6I38_RS13530	COG1605	Chorismate mutase
I6I38_RS13560	COG0531	amino acid
I6I38_RS13565	COG0174	glutamine synthetase
I6I38_RS13570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I38_RS13575	COG1917	Cupin 2, conserved barrel domain protein
I6I38_RS13575	COG1396	sequence-specific DNA binding
I6I38_RS13580	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS13585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I38_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS13595	COG0589	response to stress
I6I38_RS13600	COG1335	isochorismatase
I6I38_RS13605	COG1278	Cold shock
I6I38_RS13625	COG0673	inositol 2-dehydrogenase activity
I6I38_RS13650	COG0628	permease
I6I38_RS13665	COG0538	isocitrate dehydrogenase activity
I6I38_RS13670	COG1187	pseudouridine synthase activity
I6I38_RS13685	COG0482	sulfurtransferase activity
I6I38_RS13690	COG2915	High frequency lysogenization protein hflD homolog
I6I38_RS13695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I38_RS13730	COG0745	RESPONSE REGULATOR receiver
I6I38_RS13740	COG2850	peptidyl-arginine hydroxylation
I6I38_RS13745	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I38_RS13750	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I38_RS13755	COG1263	PTS System
I6I38_RS13755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS13760	COG1486	melibiose metabolic process
I6I38_RS13780	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I38_RS13790	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I38_RS13805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I38_RS13810	COG3706	GGDEF domain
I6I38_RS13815	COG4702	Belongs to the UPF0303 family
I6I38_RS13820	COG0659	secondary active sulfate transmembrane transporter activity
I6I38_RS13825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I38_RS13840	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I38_RS13845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I38_RS13850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I38_RS13855	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I38_RS13860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I38_RS13865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I38_RS13875	COG0193	aminoacyl-tRNA hydrolase activity
I6I38_RS13880	COG0659	secondary active sulfate transmembrane transporter activity
I6I38_RS13885	COG0012	GTP binding
I6I38_RS13890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I38_RS13900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS13905	COG1737	Transcriptional regulator
I6I38_RS13910	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS13915	COG1129	ABC transporter
I6I38_RS13920	COG1879	ABC-type sugar transport system periplasmic component
I6I38_RS13930	COG0740	serine-type endopeptidase activity
I6I38_RS13945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I38_RS13950	COG2313	pseudouridylate synthase activity
I6I38_RS13955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS13960	COG0531	amino acid
I6I38_RS13965	COG2731	YhcH YjgK YiaL family protein
I6I38_RS13970	COG3250	beta-galactosidase activity
I6I38_RS13975	COG1609	Transcriptional regulator
I6I38_RS13985	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6I38_RS13985	COG3408	Glycogen debranching enzyme
I6I38_RS13990	COG0589	response to stress
I6I38_RS13995	COG1858	cytochrome C peroxidase
I6I38_RS14025	COG1464	Belongs to the NlpA lipoprotein family
I6I38_RS14045	COG0579	oxidoreductase
I6I38_RS14055	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS14060	COG1129	ABC transporter
I6I38_RS14075	COG3290	protein histidine kinase activity
I6I38_RS14080	COG4565	transcriptional regulatory protein
I6I38_RS14110	COG3655	Transcriptional regulator
I6I38_RS14120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I38_RS14145	COG1276	copper resistance
I6I38_RS14150	COG2372	response to copper ion
I6I38_RS14155	COG1528	Iron-storage protein
I6I38_RS14175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I38_RS14180	COG1770	oligopeptidase
I6I38_RS14185	COG2979	Protein of unknown function (DUF533)
I6I38_RS14190	COG3381	protein complex oligomerization
I6I38_RS14195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I38_RS14200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I38_RS14220	COG2207	Transcriptional regulator
I6I38_RS14220	COG3708	Transcriptional regulator
I6I38_RS14225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS14240	COG3134	Outer membrane lipoprotein
I6I38_RS14245	COG1252	NADH dehydrogenase
I6I38_RS14250	COG3150	esterase
I6I38_RS14260	COG0510	thiamine kinase activity
I6I38_RS14265	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6I38_RS14270	COG5633	Lipoprotein
I6I38_RS14275	COG0537	adenosine 5'-monophosphoramidase activity
I6I38_RS14280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I38_RS14285	COG1733	regulation of RNA biosynthetic process
I6I38_RS14290	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS14300	COG0583	DNA-binding transcription factor activity
I6I38_RS14310	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I38_RS14315	COG1321	iron dependent repressor
I6I38_RS14325	COG1263	PTS System
I6I38_RS14325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS14330	COG0084	hydrolase, TatD family'
I6I38_RS14335	COG0470	DNA polymerase III
I6I38_RS14340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I38_RS14345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I38_RS14350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I38_RS14355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I38_RS14360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I38_RS14375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I38_RS14380	COG0416	fatty acid biosynthetic process
I6I38_RS14385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I38_RS14400	COG0564	pseudouridine synthase activity
I6I38_RS14405	COG1530	ribonuclease E activity
I6I38_RS14410	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I38_RS14415	COG0418	dihydroorotase activity
I6I38_RS14455	COG0628	permease
I6I38_RS14460	COG3038	cytochrome b561
I6I38_RS14465	COG2353	YceI-like domain
I6I38_RS14470	COG1054	Belongs to the UPF0176 family
I6I38_RS14475	COG1902	pentaerythritol trinitrate reductase activity
I6I38_RS14485	COG1560	Kdo2-lipid A biosynthetic process
I6I38_RS14495	COG2814	Major facilitator Superfamily
I6I38_RS14505	COG0346	lactoylglutathione lyase activity
I6I38_RS14520	COG0640	Transcriptional regulator
I6I38_RS14530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I38_RS14545	COG5645	(Lipo)protein
I6I38_RS14550	COG2943	transferase activity, transferring hexosyl groups
I6I38_RS14555	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6I38_RS14590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS14610	COG2194	sulfuric ester hydrolase activity
I6I38_RS14615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I38_RS14620	COG1486	melibiose metabolic process
I6I38_RS14625	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I38_RS14630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I38_RS14645	COG2246	polysaccharide biosynthetic process
I6I38_RS14755	COG0494	nUDIX hydrolase
I6I38_RS14790	COG3179	chitinase
I6I38_RS14845	COG0305	Participates in initiation and elongation during chromosome replication
I6I38_RS14850	COG1484	DNA-dependent DNA replication
I6I38_RS14930	COG0322	excinuclease ABC activity
I6I38_RS14935	COG2197	response regulator
I6I38_RS14945	COG3136	membrane protein required for alginate biosynthesis
I6I38_RS14990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I38_RS14995	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS15000	COG0531	amino acid
I6I38_RS15015	COG2197	response regulator
I6I38_RS15020	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I38_RS15025	COG0183	Belongs to the thiolase family
I6I38_RS15030	COG0156	8-amino-7-oxononanoate synthase activity
I6I38_RS15035	COG2814	Major facilitator Superfamily
I6I38_RS15040	COG1024	Enoyl-CoA hydratase
I6I38_RS15050	COG2271	Major facilitator Superfamily
I6I38_RS15060	COG3064	Membrane
I6I38_RS15070	COG0322	excinuclease ABC activity
I6I38_RS15080	COG1113	amino acid transport
I6I38_RS15085	COG1309	transcriptional regulator
I6I38_RS15090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS15095	COG1335	isochorismatase
I6I38_RS15100	COG0251	oxidation-reduction process
I6I38_RS15105	COG2267	carboxylic ester hydrolase activity
I6I38_RS15110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I38_RS15115	COG2233	PERMEase
I6I38_RS15140	COG1280	lysine exporter protein (LysE YggA)
I6I38_RS15145	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I38_RS15155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I38_RS15185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I38_RS15275	COG4386	tail sheath protein
I6I38_RS15465	COG0582	viral genome integration into host DNA
I6I38_RS15475	COG0670	Belongs to the BI1 family
I6I38_RS15480	COG2920	part of a sulfur-relay system
I6I38_RS15485	COG1254	Belongs to the acylphosphatase family
I6I38_RS15490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I38_RS15495	COG3785	DNA binding
I6I38_RS15500	COG1832	CoA-binding protein
I6I38_RS15510	COG1803	Methylglyoxal synthase
I6I38_RS15515	COG0210	DNA helicase
I6I38_RS15520	COG3304	Inner membrane component domain
I6I38_RS15525	COG1289	transmembrane transporter activity
I6I38_RS15530	COG3070	regulator of competence-specific genes
I6I38_RS15535	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
I6I38_RS15545	COG3120	sequence-specific DNA binding
I6I38_RS15550	COG1067	ATP-dependent peptidase activity
I6I38_RS15555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I38_RS15565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I38_RS15570	COG3130	regulation of translation
I6I38_RS15575	COG3009	Protein conserved in bacteria
I6I38_RS15580	COG3008	intermembrane lipid transfer
I6I38_RS15580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I38_RS15585	COG2995	paraquat-inducible protein a
I6I38_RS15590	COG0488	(ABC) transporter
I6I38_RS15595	COG0116	Belongs to the methyltransferase superfamily
I6I38_RS15595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I38_RS15600	COG3217	Mosc domain protein beta barrel domain protein
I6I38_RS15600	COG0633	Ferredoxin
I6I38_RS15610	COG0167	dihydroorotate dehydrogenase activity
I6I38_RS15615	COG0431	NADPH-dependent FMN reductase
I6I38_RS15620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I38_RS15625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS15630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I38_RS15640	COG0308	aminopeptidase N
I6I38_RS15645	COG3706	GGDEF domain
I6I38_RS15650	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I38_RS15655	COG0017	Asparaginyl-tRNA synthetase
I6I38_RS15665	COG1448	Aminotransferase
I6I38_RS15670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I38_RS15675	COG3108	Peptidase M15
I6I38_RS15680	COG2989	Protein conserved in bacteria
I6I38_RS15685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I38_RS15695	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6I38_RS15700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I38_RS15705	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6I38_RS15710	COG3173	Aminoglycoside phosphotransferase
I6I38_RS15715	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I38_RS15720	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I38_RS15725	COG3214	Protein conserved in bacteria
I6I38_RS15730	COG1278	Cold shock
I6I38_RS15740	COG5383	Protein conserved in bacteria
I6I38_RS15745	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I38_RS15755	COG0658	competence protein
I6I38_RS15755	COG2333	competence protein COMEC
I6I38_RS15760	COG0776	regulation of translation
I6I38_RS15765	COG0539	negative regulation of cytoplasmic translation
I6I38_RS15770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I38_RS15775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I38_RS15780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I38_RS15785	COG0252	asparaginase activity
I6I38_RS15790	COG1944	ATP diphosphatase activity
I6I38_RS15795	COG2116	formate transmembrane transporter activity
I6I38_RS15800	COG1882	Formate acetyltransferase
I6I38_RS15805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I38_RS15815	COG3381	protein complex oligomerization
I6I38_RS15820	COG3302	dmso reductase anchor subunit
I6I38_RS15825	COG0437	4 iron, 4 sulfur cluster binding
I6I38_RS15830	COG0243	molybdopterin cofactor binding
I6I38_RS15835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I38_RS15840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I38_RS15845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I38_RS15850	COG3107	peptidoglycan biosynthetic process
I6I38_RS15850	COG1674	ftsk spoiiie
I6I38_RS15860	COG0492	ferredoxin-NADP+ reductase activity
I6I38_RS15865	COG0583	DNA-binding transcription factor activity
I6I38_RS15875	COG4988	ABC transporter
I6I38_RS15880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I38_RS15885	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I38_RS15890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I38_RS15895	COG0542	response to heat
I6I38_RS15900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I38_RS15905	COG1278	Cold shock
I6I38_RS15915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS15920	COG2990	Protein conserved in bacteria
I6I38_RS15925	COG3593	DNA synthesis involved in DNA repair
I6I38_RS15930	COG2431	L-lysine efflux transmembrane transporter activity
I6I38_RS15935	COG1151	hydroxylamine reductase activity
I6I38_RS15940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I38_RS15945	COG0028	Belongs to the TPP enzyme family
I6I38_RS15950	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I38_RS15960	COG0702	epimerase
I6I38_RS15965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I38_RS15970	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I38_RS15975	COG3064	Membrane
I6I38_RS15980	COG0393	Putative heavy-metal-binding
I6I38_RS15990	COG1126	abc transporter atp-binding protein
I6I38_RS15995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS16000	COG4215	(ABC) transporter
I6I38_RS16005	COG4160	amino acid transport
I6I38_RS16010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS16015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I38_RS16025	COG1177	transmembrane transport
I6I38_RS16030	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I38_RS16035	COG3842	ATPase activity
I6I38_RS16040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I38_RS16050	COG0189	ligase activity
I6I38_RS16070	COG0569	domain protein
I6I38_RS16070	COG2985	domain, Protein
I6I38_RS16075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I38_RS16080	COG4574	serine-type endopeptidase inhibitor activity
I6I38_RS16095	COG0671	phosphoesterase, PA-phosphatase related
I6I38_RS16105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I38_RS16110	COG1349	DNA-binding transcription factor activity
I6I38_RS16115	COG0814	amino acid
I6I38_RS16120	COG1760	l-serine dehydratase
I6I38_RS16125	COG1686	Belongs to the peptidase S11 family
I6I38_RS16135	COG0626	cystathionine gamma-synthase activity
I6I38_RS16150	COG0625	glutathione transferase activity
I6I38_RS16155	COG2133	pyrroloquinoline quinone binding
I6I38_RS16165	COG0598	Magnesium transport protein CorA
I6I38_RS16170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I38_RS16185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I38_RS16195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I38_RS16205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I38_RS16220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I38_RS16225	COG0107	imidazoleglycerol-phosphate synthase activity
I6I38_RS16230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I38_RS16230	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I38_RS16235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I38_RS16255	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6I38_RS16295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I38_RS16365	COG2327	Polysaccharide pyruvyl transferase
I6I38_RS16370	COG0489	protein tyrosine kinase activity
I6I38_RS16370	COG3206	protein involved in exopolysaccharide biosynthesis
I6I38_RS16375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I38_RS16385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I38_RS16390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I38_RS16395	COG1253	flavin adenine dinucleotide binding
I6I38_RS16400	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I38_RS16405	COG2982	Protein involved in outer membrane biogenesis
I6I38_RS16410	COG0717	Belongs to the dCTP deaminase family
I6I38_RS16415	COG0572	uridine kinase
I6I38_RS16425	COG0489	protein tyrosine kinase activity
I6I38_RS16430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I38_RS16430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I38_RS16435	COG2814	Major facilitator Superfamily
I6I38_RS16440	COG1380	Effector of murein hydrolase LrgA
I6I38_RS16445	COG1346	cytolysis
I6I38_RS16450	COG0295	cytidine deaminase activity
I6I38_RS16455	COG0281	malic enzyme
I6I38_RS16460	COG2949	membrane
I6I38_RS16480	COG1609	Transcriptional regulator
I6I38_RS16485	COG2311	Membrane
I6I38_RS16490	COG0302	gtp cyclohydrolase
I6I38_RS16495	COG0477	Major facilitator Superfamily
I6I38_RS16500	COG0583	DNA-binding transcription factor activity
I6I38_RS16530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I38_RS16535	COG0601	transmembrane transport
I6I38_RS16540	COG0747	negative chemotaxis
I6I38_RS16545	COG4172	Belongs to the ABC transporter superfamily
I6I38_RS16560	COG0303	'Molybdopterin
I6I38_RS16565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I38_RS16570	COG0488	(ABC) transporter
I6I38_RS16580	COG0583	DNA-binding transcription factor activity
I6I38_RS16585	COG0288	reversible hydration of carbon dioxide
I6I38_RS16590	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I38_RS16605	COG0640	Transcriptional regulator
I6I38_RS16610	COG0625	glutathione transferase activity
I6I38_RS16625	COG0579	oxidoreductase
I6I38_RS16630	COG3708	Transcriptional regulator
I6I38_RS16630	COG2207	Transcriptional regulator
I6I38_RS16640	COG3188	usher protein
I6I38_RS16645	COG3121	Chaperone
I6I38_RS16655	COG2200	EAL domain
I6I38_RS16665	COG0069	glutamate synthase activity
I6I38_RS16670	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I38_RS16675	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS16680	COG1309	transcriptional regulator
I6I38_RS16685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I38_RS16705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I38_RS16710	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6I38_RS16715	COG0745	RESPONSE REGULATOR receiver
I6I38_RS16720	COG5002	protein histidine kinase activity
I6I38_RS16735	COG3188	usher protein
I6I38_RS16775	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6I38_RS16780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I38_RS16785	COG1349	DNA-binding transcription factor activity
I6I38_RS16790	COG2084	Dehydrogenase
I6I38_RS16795	COG3395	kinase activity
I6I38_RS16800	COG0235	Class ii aldolase
I6I38_RS16805	COG3622	Belongs to the hyi family
I6I38_RS16810	COG2610	gluconate transmembrane transporter activity
I6I38_RS16825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I38_RS16830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I38_RS16840	COG2731	YhcH YjgK YiaL family protein
I6I38_RS16850	COG0783	Belongs to the Dps family
I6I38_RS16855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I38_RS16860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS16865	COG0765	amino acid transport
I6I38_RS16870	COG1126	abc transporter atp-binding protein
I6I38_RS16875	COG0668	transmembrane transport
I6I38_RS16885	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6I38_RS16890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I38_RS16905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I38_RS16915	COG0477	Major facilitator Superfamily
I6I38_RS16925	COG1280	lysine exporter protein (LysE YggA)
I6I38_RS16930	COG0583	DNA-binding transcription factor activity
I6I38_RS16935	COG2814	Major facilitator Superfamily
I6I38_RS16940	COG0697	spore germination
I6I38_RS16945	COG1522	sequence-specific DNA binding
I6I38_RS16950	COG1199	ATP-dependent helicase activity
I6I38_RS16975	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6I38_RS17000	COG0697	spore germination
I6I38_RS17025	COG1174	glycine betaine transport
I6I38_RS17030	COG1125	glycine betaine transport
I6I38_RS17035	COG1174	glycine betaine transport
I6I38_RS17040	COG1732	Glycine betaine
I6I38_RS17055	COG0583	DNA-binding transcription factor activity
I6I38_RS17060	COG1335	isochorismatase
I6I38_RS17070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I38_RS17080	COG0625	glutathione transferase activity
I6I38_RS17090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I38_RS17095	COG4221	oxidoreductase activity
I6I38_RS17110	COG1683	Conserved Protein
I6I38_RS17120	COG2897	thiosulfate sulfurtransferase activity
I6I38_RS17125	COG0583	DNA-binding transcription factor activity
I6I38_RS17130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I38_RS17145	COG3511	phospholipase C
I6I38_RS17190	COG1802	Transcriptional regulator
I6I38_RS17210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS17230	COG0840	transmembrane signaling receptor activity
I6I38_RS17235	COG4807	Protein conserved in bacteria
I6I38_RS17255	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I38_RS17265	COG1063	alcohol dehydrogenase
I6I38_RS17270	COG1802	Transcriptional regulator
I6I38_RS17275	COG2271	Major facilitator Superfamily
I6I38_RS17285	COG0583	DNA-binding transcription factor activity
I6I38_RS17295	COG2084	Dehydrogenase
I6I38_RS17300	COG1335	isochorismatase
I6I38_RS17320	COG0583	DNA-binding transcription factor activity
I6I38_RS17330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I38_RS17335	COG2011	ABC-type metal ion transport system permease component
I6I38_RS17340	COG1464	Belongs to the NlpA lipoprotein family
I6I38_RS17345	COG1309	transcriptional regulator
I6I38_RS17380	COG0366	Alpha amylase catalytic
I6I38_RS17405	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I38_RS17410	COG1070	Carbohydrate kinase
I6I38_RS17435	COG1192	Involved in chromosome partitioning
I6I38_RS17450	COG1120	ATPase activity
I6I38_RS17455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I38_RS17460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I38_RS17465	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I38_RS17475	COG0436	Aminotransferase
I6I38_RS17485	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I38_RS17500	COG0277	FAD linked oxidase domain protein
I6I38_RS17505	COG0840	transmembrane signaling receptor activity
I6I38_RS17510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I38_RS17540	COG1464	Belongs to the NlpA lipoprotein family
I6I38_RS17550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I38_RS17565	COG2354	Protein conserved in bacteria
I6I38_RS17575	COG4566	intracellular signal transduction
I6I38_RS17580	COG4191	Histidine kinase
I6I38_RS17595	COG1686	Belongs to the peptidase S11 family
I6I38_RS17600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I38_RS17605	COG4977	sequence-specific DNA binding
I6I38_RS17615	COG0586	Pfam SNARE associated Golgi protein
I6I38_RS17620	COG1280	lysine exporter protein (LysE YggA)
I6I38_RS17625	COG0583	DNA-binding transcription factor activity
I6I38_RS17645	COG0583	DNA-binding transcription factor activity
I6I38_RS17660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I38_RS17685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I38_RS17690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I38_RS17705	COG0477	Major facilitator Superfamily
I6I38_RS17715	COG0513	Belongs to the DEAD box helicase family
I6I38_RS17720	COG1309	transcriptional regulator
I6I38_RS17725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS17730	COG1131	(ABC) transporter
I6I38_RS17735	COG0842	Transport permease protein
I6I38_RS17740	COG0842	Transport permease protein
I6I38_RS17745	COG0670	Belongs to the BI1 family
I6I38_RS17750	COG0314	molybdopterin synthase activity
I6I38_RS17755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6I38_RS17760	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I38_RS17765	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I38_RS17770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I38_RS17775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I38_RS17780	COG4628	conserved protein (DUF2132)
I6I38_RS17785	COG0556	nucleotide-excision repair
I6I38_RS17810	COG0156	8-amino-7-oxononanoate synthase activity
I6I38_RS17815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I38_RS17830	COG1881	PFAM PEBP family protein
I6I38_RS17835	COG2706	6-phosphogluconolactonase activity
I6I38_RS17840	COG0561	phosphatase activity
I6I38_RS17850	COG4149	molybdate abc transporter
I6I38_RS17855	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I38_RS17865	COG1120	ATPase activity
I6I38_RS17870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I38_RS17875	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I38_RS17885	COG4774	siderophore transport
I6I38_RS17890	COG3585	molybdate ion transport
I6I38_RS17890	COG2005	Transcriptional regulator
I6I38_RS17895	COG1119	ATPase activity
I6I38_RS17910	COG1085	galactose-1-phosphate uridylyltransferase
I6I38_RS17915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I38_RS17920	COG2017	converts alpha-aldose to the beta-anomer
I6I38_RS17930	COG0588	phosphoglycerate mutase activity
I6I38_RS17935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I38_RS17940	COG2197	response regulator
I6I38_RS17945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS17945	COG2205	protein histidine kinase activity
I6I38_RS17950	COG1230	cation diffusion facilitator family transporter
I6I38_RS17960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I38_RS17990	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6I38_RS17995	COG2885	chlorophyll binding
I6I38_RS18000	COG0823	Involved in the tonB-independent uptake of proteins
I6I38_RS18005	COG3064	Membrane
I6I38_RS18010	COG0848	biopolymer transport protein
I6I38_RS18015	COG0811	peptide transport
I6I38_RS18020	COG0824	Thioesterase
I6I38_RS18025	COG3790	cyd operon protein YbgE
I6I38_RS18030	COG4890	Cyd operon protein YbgT
I6I38_RS18035	COG1294	oxidase, subunit
I6I38_RS18040	COG1271	oxidase subunit
I6I38_RS18045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I38_RS18050	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I38_RS18055	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I38_RS18060	COG0567	Dehydrogenase, E1 component
I6I38_RS18065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I38_RS18075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I38_RS18080	COG2009	succinate dehydrogenase
I6I38_RS18110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I38_RS18115	COG1984	allophanate hydrolase subunit 2
I6I38_RS18120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I38_RS18125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I38_RS18130	COG5212	phosphodiesterase
I6I38_RS18140	COG3272	Protein of unknown function (DUF1722)
I6I38_RS18155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I38_RS18160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I38_RS18165	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I38_RS18170	COG2205	protein histidine kinase activity
I6I38_RS18175	COG0745	RESPONSE REGULATOR receiver
I6I38_RS18185	COG1695	Transcriptional regulator
I6I38_RS18190	COG0033	Phosphoglucomutase
I6I38_RS18195	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6I38_RS18200	COG0596	Alpha beta hydrolase
I6I38_RS18215	COG0735	belongs to the Fur family
I6I38_RS18225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I38_RS18230	COG2814	Major facilitator Superfamily
I6I38_RS18250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I38_RS18260	COG0363	glucosamine-6-phosphate deaminase activity
I6I38_RS18265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I38_RS18270	COG1846	Transcriptional regulator
I6I38_RS18270	COG1940	carbohydrate kinase activity
I6I38_RS18275	COG0647	UMP catabolic process
I6I38_RS18280	COG3469	chitinase activity
I6I38_RS18285	COG0367	asparagine synthase
I6I38_RS18320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I38_RS18325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I38_RS18330	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I38_RS18335	COG1702	phosphate starvation-inducible protein PhoH
I6I38_RS18340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I38_RS18345	COG4535	Mg2 and Co2 transporter CorC
I6I38_RS18350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I38_RS18360	COG0765	amino acid transport
I6I38_RS18365	COG0765	amino acid transport
I6I38_RS18370	COG1126	abc transporter atp-binding protein
I6I38_RS18375	COG1957	nucleoside hydrolase
I6I38_RS18385	COG2888	peptidyl-tyrosine sulfation
I6I38_RS18390	COG0495	leucyl-tRNA aminoacylation
I6I38_RS18395	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6I38_RS18400	COG1466	dna polymerase III delta subunit
I6I38_RS18405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I38_RS18410	COG0799	negative regulation of ribosome biogenesis
I6I38_RS18415	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I38_RS18420	COG0768	penicillin binding
I6I38_RS18425	COG0772	Belongs to the SEDS family
I6I38_RS18430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I38_RS18435	COG1686	Belongs to the peptidase S11 family
I6I38_RS18440	COG2921	Belongs to the UPF0250 family
I6I38_RS18445	COG0321	lipoyl(octanoyl) transferase activity
I6I38_RS18450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I38_RS18460	COG3706	GGDEF domain
I6I38_RS18465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I38_RS18475	COG2814	Major facilitator Superfamily
I6I38_RS18485	COG1473	amidohydrolase
I6I38_RS18490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS18495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS18505	COG0765	amino acid transport
I6I38_RS18510	COG1126	abc transporter atp-binding protein
I6I38_RS18520	COG1278	Cold shock
I6I38_RS18530	COG2199	diguanylate cyclase activity
I6I38_RS18540	COG0583	DNA-binding transcription factor activity
I6I38_RS18545	COG0667	Aldo Keto reductase
I6I38_RS18565	COG0583	DNA-binding transcription factor activity
I6I38_RS18575	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6I38_RS18580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I38_RS18595	COG1917	Cupin 2, conserved barrel domain protein
I6I38_RS18615	COG0604	alcohol dehydrogenase
I6I38_RS18620	COG0604	alcohol dehydrogenase
I6I38_RS18630	COG2259	Doxx family
I6I38_RS18645	COG1309	transcriptional regulator
I6I38_RS18650	COG2995	paraquat-inducible protein a
I6I38_RS18655	COG3008	intermembrane lipid transfer
I6I38_RS18655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I38_RS18660	COG3009	Protein conserved in bacteria
I6I38_RS18670	COG0183	Belongs to the thiolase family
I6I38_RS18675	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS18700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I38_RS18705	COG2501	S4 domain
I6I38_RS18710	COG0215	cysteine-tRNA ligase activity
I6I38_RS18715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I38_RS18720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I38_RS18725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I38_RS18730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I38_RS18740	COG2814	Major facilitator Superfamily
I6I38_RS18745	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I38_RS18750	COG4181	ATPase activity
I6I38_RS18755	COG2755	lipolytic protein G-D-S-L family
I6I38_RS18760	COG0300	oxidoreductase activity
I6I38_RS18765	COG3118	belongs to the thioredoxin family
I6I38_RS18770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I38_RS18775	COG0330	HflC and HflK could
I6I38_RS18780	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I38_RS18785	COG0789	Transcriptional regulator
I6I38_RS18790	COG2217	Heavy metal translocating P-type atpase
I6I38_RS18795	COG3735	TraB family
I6I38_RS18800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I38_RS18805	COG2020	methyltransferase activity
I6I38_RS18810	COG0737	Belongs to the 5'-nucleotidase family
I6I38_RS18815	COG2223	nitrite transmembrane transporter activity
I6I38_RS18820	COG4651	solute:proton antiporter activity
I6I38_RS18820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I38_RS18825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS18830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I38_RS18835	COG1929	Belongs to the glycerate kinase type-1 family
I6I38_RS18840	COG2610	gluconate transmembrane transporter activity
I6I38_RS18845	COG3835	regulator
I6I38_RS18850	COG0563	adenylate kinase activity
I6I38_RS18855	COG0326	Molecular chaperone. Has ATPase activity
I6I38_RS18860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I38_RS18865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I38_RS18870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I38_RS18875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I38_RS18880	COG2832	Protein of unknown function (DUF454)
I6I38_RS18895	COG3264	Mechanosensitive ion channel
I6I38_RS18895	COG1196	nuclear chromosome segregation
I6I38_RS18900	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I38_RS18905	COG1309	transcriptional regulator
I6I38_RS18910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I38_RS18915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I38_RS18920	COG0254	rRNA binding
I6I38_RS18925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I38_RS18930	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I38_RS18935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I38_RS18940	COG1121	(ABC) transporter
I6I38_RS18965	COG0583	DNA-binding transcription factor activity
I6I38_RS18970	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6I38_RS18975	COG2252	PERMEase
I6I38_RS18985	COG3695	enzyme binding
I6I38_RS18990	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6I38_RS18995	COG1946	Acyl-CoA thioesterase
I6I38_RS19005	COG0688	phosphatidylethanolamine metabolic process
I6I38_RS19010	COG2258	MOSC domain
I6I38_RS19015	COG0004	ammonium transporteR
I6I38_RS19020	COG0347	Belongs to the P(II) protein family
I6I38_RS19025	COG1132	(ABC) transporter
I6I38_RS19030	COG1132	(ABC) transporter
I6I38_RS19035	COG1522	sequence-specific DNA binding
I6I38_RS19045	COG0561	phosphatase activity
I6I38_RS19050	COG4533	DNA binding
I6I38_RS19055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I38_RS19060	COG0824	Thioesterase
I6I38_RS19065	COG1555	photosystem II stabilization
I6I38_RS19070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I38_RS19080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I38_RS19085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I38_RS19095	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I38_RS19100	COG0271	Belongs to the BolA IbaG family
I6I38_RS19105	COG3056	Lipoprotein
I6I38_RS19110	COG2223	nitrite transmembrane transporter activity
I6I38_RS19115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I38_RS19120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I38_RS19125	COG1845	cytochrome c oxidase, subunit III
I6I38_RS19130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I38_RS19135	COG0109	protoheme IX farnesyltransferase activity
I6I38_RS19140	COG2814	Major facilitator Superfamily
I6I38_RS19145	COG1666	GTP binding
I6I38_RS19150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I38_RS19155	COG0693	protein deglycase activity
I6I38_RS19160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I38_RS19160	COG0301	tRNA thio-modification
I6I38_RS19165	COG1722	exodeoxyribonuclease VII activity
I6I38_RS19170	COG0142	geranyltranstransferase activity
I6I38_RS19175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I38_RS19180	COG0667	Aldo Keto reductase
I6I38_RS19185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I38_RS19190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I38_RS19195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I38_RS19200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I38_RS19205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I38_RS19205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I38_RS19210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I38_RS19245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I38_RS19250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I38_RS19255	COG1862	Preprotein translocase
I6I38_RS19260	COG0343	queuine tRNA-ribosyltransferase activity
I6I38_RS19265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I38_RS19270	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6I38_RS19275	COG0450	alkyl hydroperoxide reductase
I6I38_RS19285	COG0366	Alpha amylase catalytic
I6I38_RS19290	COG0668	transmembrane transport
I6I38_RS19310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I38_RS19320	COG5002	protein histidine kinase activity
I6I38_RS19325	COG0745	RESPONSE REGULATOR receiver
I6I38_RS19330	COG0420	3'-5' exonuclease activity
I6I38_RS19335	COG0419	ATPase involved in DNA repair
I6I38_RS19345	COG1940	carbohydrate kinase activity
I6I38_RS19360	COG0191	fructose-bisphosphate aldolase activity
I6I38_RS19375	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS19380	COG1129	ABC transporter
I6I38_RS19390	COG2974	May be involved in recombination
I6I38_RS19395	COG3123	guanosine phosphorylase activity
I6I38_RS19400	COG4126	flavin adenine dinucleotide binding
I6I38_RS19415	COG1414	Transcriptional regulator
I6I38_RS19440	COG0667	Aldo Keto reductase
I6I38_RS19445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I38_RS19495	COG2226	methyltransferase
I6I38_RS19505	COG3416	Protein conserved in bacteria
I6I38_RS19520	COG3011	Protein conserved in bacteria
I6I38_RS19535	COG1335	isochorismatase
I6I38_RS19550	COG0346	lactoylglutathione lyase activity
I6I38_RS19555	COG1349	DNA-binding transcription factor activity
I6I38_RS19585	COG3961	Belongs to the TPP enzyme family
I6I38_RS19605	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS19610	COG2207	Transcriptional regulator
I6I38_RS19620	COG3391	amine dehydrogenase activity
I6I38_RS19625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I38_RS19630	COG4774	siderophore transport
I6I38_RS19630	COG1629	transport
I6I38_RS19635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I38_RS19640	COG3433	isochorismatase activity
I6I38_RS19640	COG2226	methyltransferase
I6I38_RS19640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I38_RS19655	COG0747	negative chemotaxis
I6I38_RS19660	COG3038	cytochrome b561
I6I38_RS19670	COG3423	Transcriptional regulator
I6I38_RS19680	COG0583	DNA-binding transcription factor activity
I6I38_RS19690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I38_RS19695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I38_RS19700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I38_RS19710	COG1073	alpha beta
I6I38_RS19715	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I38_RS19720	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I38_RS19725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I38_RS19730	COG0584	glycerophosphoryl diester phosphodiesterase
I6I38_RS19735	COG2991	Protein conserved in bacteria
I6I38_RS19740	COG1477	protein flavinylation
I6I38_RS19745	COG2871	sodium ion transport
I6I38_RS19750	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I38_RS19755	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I38_RS19760	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I38_RS19765	COG1805	sodium ion transport
I6I38_RS19770	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I38_RS19775	COG3034	peptidoglycan biosynthetic process
I6I38_RS19780	COG0121	glutamine amidotransferase
I6I38_RS19785	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I38_RS19790	COG1960	acyl-CoA dehydrogenase activity
I6I38_RS19800	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I6I38_RS19805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6I38_RS19810	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6I38_RS19815	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6I38_RS19820	COG0235	Class ii aldolase
I6I38_RS19825	COG0436	Aminotransferase
I6I38_RS19840	COG2351	hydroxyisourate hydrolase activity
I6I38_RS19855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I38_RS19860	COG1126	abc transporter atp-binding protein
I6I38_RS19865	COG0765	amino acid transport
I6I38_RS19915	COG2375	cellular response to nickel ion
I6I38_RS19965	COG1953	Uracil, thiamine, allantoin
I6I38_RS19975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I38_RS19980	COG0328	RNA-DNA hybrid ribonuclease activity
I6I38_RS19985	COG2226	methyltransferase
I6I38_RS19990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I38_RS19995	COG0741	lytic transglycosylase activity
I6I38_RS19995	COG1388	LysM domain
I6I38_RS20005	COG2814	Major facilitator Superfamily
I6I38_RS20010	COG0583	DNA-binding transcription factor activity
I6I38_RS20015	COG0656	L-ascorbic acid biosynthetic process
I6I38_RS20020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I38_RS20025	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS20030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I38_RS20035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I38_RS20065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I38_RS20070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I38_RS20080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I38_RS20130	COG0542	response to heat
I6I38_RS20140	COG0564	pseudouridine synthase activity
I6I38_RS20145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I38_RS20150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I38_RS20160	COG0077	Prephenate dehydratase
I6I38_RS20160	COG1605	Chorismate mutase
I6I38_RS20165	COG1605	Chorismate mutase
I6I38_RS20165	COG0287	Prephenate dehydrogenase
I6I38_RS20170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I38_RS20175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I38_RS20180	COG3137	Salt-induced outer membrane protein
I6I38_RS20190	COG0335	large ribosomal subunit rRNA binding
I6I38_RS20200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I38_RS20205	COG0228	four-way junction DNA binding
I6I38_RS20210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I38_RS20215	COG4137	Cytochrome C assembly protein
I6I38_RS20220	COG4536	flavin adenine dinucleotide binding
I6I38_RS20225	COG1854	S-ribosylhomocysteine lyase activity
I6I38_RS20230	COG2918	glutathione biosynthetic process
I6I38_RS20235	COG1238	metal cluster binding
I6I38_RS20240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I38_RS20270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I38_RS20275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I38_RS20280	COG2137	regulation of response to DNA damage stimulus
I6I38_RS20285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I38_RS20305	COG1917	Cupin 2, conserved barrel domain protein
I6I38_RS20305	COG2169	Transcriptional regulator
I6I38_RS20310	COG2723	6-phospho-beta-galactosidase activity
I6I38_RS20315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I38_RS20320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I38_RS20325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I38_RS20330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I38_RS20335	COG4942	peptidase
I6I38_RS20335	COG1388	LysM domain
I6I38_RS20340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I38_RS20345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I38_RS20350	COG0585	pseudouridine synthase activity
I6I38_RS20355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I38_RS20360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I38_RS20365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6I38_RS20375	COG0765	amino acid transport
I6I38_RS20390	COG0529	Catalyzes the synthesis of activated sulfate
I6I38_RS20395	COG2895	sulfate adenylyltransferase (ATP) activity
I6I38_RS20400	COG0175	sulfate reduction
I6I38_RS20405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I38_RS20405	COG1648	precorrin-2 dehydrogenase activity
I6I38_RS20410	COG2234	aminopeptidase activity
I6I38_RS20415	COG0175	sulfate reduction
I6I38_RS20420	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I38_RS20425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I38_RS20430	COG0720	synthase
I6I38_RS20435	COG0602	queuosine metabolic process
I6I38_RS20440	COG2271	Major facilitator Superfamily
I6I38_RS20445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I38_RS20450	COG2986	histidine ammonia-lyase
I6I38_RS20465	COG4176	ABC-type proline glycine betaine transport system permease component
I6I38_RS20470	COG4175	Glycine betaine
I6I38_RS20475	COG2986	histidine ammonia-lyase
I6I38_RS20495	COG0148	phosphopyruvate hydratase activity
I6I38_RS20500	COG0504	CTP synthase activity
I6I38_RS20505	COG3956	TIGRFAM MazG family protein
I6I38_RS20510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I38_RS20515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I38_RS20525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I38_RS20530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I38_RS20535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I38_RS20545	COG2860	membrane
I6I38_RS20555	COG0316	Belongs to the HesB IscA family
I6I38_RS20565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I38_RS20570	COG3725	Membrane protein required for beta-lactamase induction
I6I38_RS20575	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I38_RS20585	COG4969	Belongs to the N-Me-Phe pilin family
I6I38_RS20590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I38_RS20595	COG1459	type II secretion system
I6I38_RS20600	COG0516	GMP reductase activity
I6I38_RS20610	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6I38_RS20615	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I38_RS20620	COG0494	nUDIX hydrolase
I6I38_RS20625	COG0653	protein targeting
I6I38_RS20645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I38_RS20650	COG0849	cell division
I6I38_RS20655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I38_RS20665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I38_RS20670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I38_RS20675	COG0772	Belongs to the SEDS family
I6I38_RS20685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I38_RS20690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I38_RS20695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I38_RS20700	COG0768	penicillin binding
I6I38_RS20705	COG3116	cell division
I6I38_RS20710	COG0275	rRNA processing
I6I38_RS20715	COG2001	Belongs to the MraZ family
I6I38_RS20735	COG0028	Belongs to the TPP enzyme family
I6I38_RS20740	COG1022	Amp-dependent synthetase and ligase
I6I38_RS20745	COG0583	DNA-binding transcription factor activity
I6I38_RS20755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I38_RS20760	COG0473	3-isopropylmalate dehydrogenase activity
I6I38_RS20765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I38_RS20770	COG0066	3-isopropylmalate dehydratase activity
I6I38_RS20775	COG0471	metal ion transport
I6I38_RS20780	COG2814	Major facilitator Superfamily
I6I38_RS20795	COG4143	(ABC) transporter
I6I38_RS20800	COG1178	ABC-type Fe3 transport system permease component
I6I38_RS20815	COG0028	Belongs to the TPP enzyme family
I6I38_RS20820	COG0440	acetolactate synthase activity
I6I38_RS20825	COG0586	Pfam SNARE associated Golgi protein
I6I38_RS20830	COG0417	DNA replication proofreading
I6I38_RS20835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I38_RS20840	COG0564	pseudouridine synthase activity
I6I38_RS20850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I38_RS20860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I38_RS20865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I38_RS20870	COG2967	ApaG domain
I6I38_RS20875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I38_RS20885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I38_RS20895	COG2966	Psort location CytoplasmicMembrane, score
I6I38_RS20910	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I38_RS20915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I38_RS20920	COG0505	Belongs to the CarA family
I6I38_RS20925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I38_RS20930	COG2186	Transcriptional regulator
I6I38_RS20935	COG3734	2-keto-3-deoxy-galactonokinase
I6I38_RS20940	COG0800	Aldolase
I6I38_RS20945	COG2814	Major facilitator Superfamily
I6I38_RS20950	COG2271	Major facilitator Superfamily
I6I38_RS20955	COG0129	dihydroxy-acid dehydratase activity
I6I38_RS20960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I38_RS20965	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS20990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I38_RS20995	COG1047	Peptidyl-prolyl cis-trans
I6I38_RS21000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I38_RS21005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I38_RS21010	COG0196	riboflavin kinase activity
I6I38_RS21015	COG0268	Binds directly to 16S ribosomal RNA
I6I38_RS21020	COG0583	DNA-binding transcription factor activity
I6I38_RS21025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I38_RS21030	COG0484	heat shock protein binding
I6I38_RS21035	COG0443	Heat shock 70 kDa protein
I6I38_RS21040	COG1584	GPR1 FUN34 yaaH family protein
I6I38_RS21050	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I38_RS21055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I38_RS21060	COG1115	amino acid carrier protein
I6I38_RS21065	COG3022	response to hydroperoxide
I6I38_RS21075	COG0083	homoserine kinase activity
I6I38_RS21095	COG0745	RESPONSE REGULATOR receiver
I6I38_RS21100	COG3045	CreA protein
I6I38_RS21105	COG2207	Transcriptional regulator
I6I38_RS21105	COG3708	Transcriptional regulator
I6I38_RS21110	COG0406	alpha-ribazole phosphatase activity
I6I38_RS21115	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6I38_RS21120	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6I38_RS21125	COG0741	lytic transglycosylase activity
I6I38_RS21135	COG2199	diguanylate cyclase activity
I6I38_RS21140	COG2885	chlorophyll binding
I6I38_RS21145	COG0488	(ABC) transporter
I6I38_RS21155	COG0604	alcohol dehydrogenase
I6I38_RS21170	COG0560	Phosphoserine phosphatase
I6I38_RS21175	COG3726	membrane protein affecting hemolysin expression
I6I38_RS21185	COG0813	purine-nucleoside phosphorylase activity
I6I38_RS21190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I38_RS21195	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I38_RS21200	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I38_RS21205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I38_RS21210	COG0084	hydrolase, TatD family'
I6I38_RS21215	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I38_RS21220	COG3237	CsbD-like
I6I38_RS21225	COG5487	UPF0391 membrane protein
I6I38_RS21230	COG2823	Periplasmic or secreted lipoprotein
I6I38_RS21235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I38_RS21245	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6I38_RS21250	COG2813	Specifically methylates the guanine in position
I6I38_RS21255	COG0667	Aldo Keto reductase
I6I38_RS21290	COG0738	Major facilitator superfamily
I6I38_RS21295	COG3254	rhamnose metabolic process
I6I38_RS21300	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS21305	COG3618	amidohydrolase
I6I38_RS21310	COG4948	Mandelate Racemase Muconate Lactonizing
I6I38_RS21315	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I38_RS21320	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS21330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I38_RS21335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I38_RS21340	COG2368	4-hydroxyphenylacetate
I6I38_RS21360	COG3971	2-oxopent-4-enoate hydratase activity
I6I38_RS21375	COG1012	belongs to the aldehyde dehydrogenase family
I6I38_RS21390	COG1846	Transcriptional regulator
I6I38_RS21395	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS21415	COG1113	amino acid transport
I6I38_RS21435	COG2267	carboxylic ester hydrolase activity
I6I38_RS21445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I38_RS21455	COG1454	alcohol dehydrogenase
I6I38_RS21490	COG0811	peptide transport
I6I38_RS21510	COG1376	ErfK ybiS ycfS ynhG family protein
I6I38_RS21515	COG3708	Transcriptional regulator
I6I38_RS21515	COG2207	Transcriptional regulator
I6I38_RS21525	COG2207	Transcriptional regulator
I6I38_RS21535	COG3391	amine dehydrogenase activity
I6I38_RS21555	COG0174	glutamine synthetase
I6I38_RS21565	COG1966	Carbon starvation protein
I6I38_RS21570	COG2879	small protein
I6I38_RS21575	COG0523	cobalamin synthesis protein
I6I38_RS21600	COG3483	tryptophan 2,3-dioxygenase activity
I6I38_RS21610	COG2814	Major facilitator Superfamily
I6I38_RS21620	COG1609	Transcriptional regulator
I6I38_RS21630	COG1263	PTS System
I6I38_RS21630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS21635	COG2723	6-phospho-beta-galactosidase activity
I6I38_RS21650	COG1715	Restriction endonuclease
I6I38_RS21665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I38_RS21675	COG3550	peptidyl-serine autophosphorylation
I6I38_RS21680	COG1396	sequence-specific DNA binding
I6I38_RS21695	COG0795	lipopolysaccharide-transporting ATPase activity
I6I38_RS21700	COG0795	lipopolysaccharide-transporting ATPase activity
I6I38_RS21705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I38_RS21710	COG2927	DNA polymerase III (CHI subunit)
I6I38_RS21720	COG0456	acetyltransferase
I6I38_RS21730	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I38_RS21740	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6I38_RS21745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I38_RS21750	COG4166	transmembrane transport
I6I38_RS21760	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I38_RS21775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I38_RS21785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I38_RS21790	COG0540	Belongs to the ATCase OTCase family
I6I38_RS21795	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6I38_RS21810	COG2308	Evidence 4 Homologs of previously reported genes of
I6I38_RS21890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I38_RS21890	COG1263	PTS System
I6I38_RS21895	COG0366	Alpha amylase catalytic
I6I38_RS21900	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I38_RS21905	COG0583	DNA-binding transcription factor activity
I6I38_RS21915	COG0602	queuosine metabolic process
I6I38_RS21930	COG0701	Predicted permease
I6I38_RS21935	COG2188	Transcriptional regulator
I6I38_RS21940	COG3624	Phosphonate C-P lyase system protein PhnG
I6I38_RS21945	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I38_RS21950	COG3626	phosphonate metabolism
I6I38_RS21955	COG3627	carbon phosphorus lyase activity
I6I38_RS21960	COG4107	phosphonate C-P lyase system protein PhnK
I6I38_RS21965	COG4778	phosphonate C-P lyase system protein PhnL
I6I38_RS21970	COG3454	Phosphonate metabolism
I6I38_RS21975	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I38_RS21985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I38_RS21990	COG0702	epimerase
I6I38_RS21995	COG3787	Belongs to the UPF0306 family
I6I38_RS22005	COG1982	Orn Lys Arg decarboxylase major
I6I38_RS22010	COG0531	amino acid
I6I38_RS22020	COG3153	acetyltransferase
I6I38_RS22025	COG3154	lipid carrier protein
I6I38_RS22030	COG0826	peptidase U32
I6I38_RS22035	COG0826	peptidase U32
I6I38_RS22040	COG2850	peptidyl-arginine hydroxylation
I6I38_RS22060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I38_RS22065	COG0425	Belongs to the sulfur carrier protein TusA family
I6I38_RS22070	COG2391	methyltransferase activity
I6I38_RS22075	COG0513	Belongs to the DEAD box helicase family
I6I38_RS22090	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I38_RS22095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I38_RS22100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I38_RS22105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I38_RS22110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I38_RS22115	COG0195	Participates in both transcription termination and antitermination
I6I38_RS22120	COG0779	Required for maturation of 30S ribosomal subunits
I6I38_RS22135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I38_RS22140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I38_RS22145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I38_RS22150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I38_RS22155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I38_RS22160	COG1534	Rna-binding protein
I6I38_RS22170	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I38_RS22175	COG0745	RESPONSE REGULATOR receiver
I6I38_RS22180	COG0642	Histidine kinase
I6I38_RS22185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I38_RS22190	COG0697	spore germination
I6I38_RS22195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I38_RS22200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I38_RS22205	COG0142	geranyltranstransferase activity
I6I38_RS22215	COG3423	Transcriptional regulator
I6I38_RS22220	COG0039	L-malate dehydrogenase activity
I6I38_RS22230	COG1438	arginine binding
I6I38_RS22245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I38_RS22250	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I38_RS22255	COG0840	transmembrane signaling receptor activity
I6I38_RS22260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I38_RS22265	COG2105	PFAM AIG2 family protein
I6I38_RS22270	COG2911	Protein conserved in bacteria
I6I38_RS22275	COG0729	surface antigen
I6I38_RS22280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I38_RS22285	COG1253	flavin adenine dinucleotide binding
I6I38_RS22295	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6I38_RS22300	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I38_RS22305	COG0737	Belongs to the 5'-nucleotidase family
I6I38_RS22310	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I38_RS22315	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I38_RS22320	COG3061	Opacity-associated protein A
I6I38_RS22330	COG0359	binds to the 23S rRNA
I6I38_RS22335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I38_RS22345	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I38_RS22355	COG1073	alpha beta
I6I38_RS22360	COG3650	response to hydrogen peroxide
I6I38_RS22370	COG3766	membrane
I6I38_RS22375	COG1960	acyl-CoA dehydrogenase activity
I6I38_RS22380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I38_RS22385	COG0557	exoribonuclease II activity
I6I38_RS22390	COG1959	2 iron, 2 sulfur cluster binding
I6I38_RS22395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I38_RS22400	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6I38_RS22405	COG0330	HflC and HflK could
I6I38_RS22410	COG0330	HflC and HflK could
I6I38_RS22415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I38_RS22420	COG1923	regulation of RNA biosynthetic process
I6I38_RS22425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I38_RS22430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I38_RS22435	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I38_RS22440	COG0802	atpase or kinase
I6I38_RS22445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I38_RS22445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I38_RS22450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I38_RS22470	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I38_RS22475	COG1162	GTPase activity
I6I38_RS22480	COG0688	phosphatidylethanolamine metabolic process
I6I38_RS22485	COG1511	domain protein
I6I38_RS22485	COG3264	Mechanosensitive ion channel
I6I38_RS22490	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6I38_RS22495	COG1053	succinate dehydrogenase
I6I38_RS22500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I38_RS22505	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I38_RS22510	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I38_RS22525	COG5510	response to toxic substance
I6I38_RS22535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I38_RS22555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I38_RS22570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I38_RS22580	COG4232	protein-disulfide reductase activity
I6I38_RS22585	COG1309	transcriptional regulator
I6I38_RS22595	COG0784	Response regulator, receiver
I6I38_RS22595	COG2198	Histidine kinase
I6I38_RS22595	COG2205	protein histidine kinase activity
I6I38_RS22600	COG1879	ABC-type sugar transport system periplasmic component
I6I38_RS22605	COG3005	denitrification pathway
I6I38_RS22610	COG0243	molybdopterin cofactor binding
I6I38_RS22625	COG3647	Membrane
I6I38_RS22630	COG4942	peptidase
I6I38_RS22635	COG1301	dicarboxylic acid transport
I6I38_RS22640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I38_RS22645	COG3162	membrane
I6I38_RS22650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I38_RS22680	COG0138	bifunctional purine biosynthesis protein purh
I6I38_RS22685	COG0151	Belongs to the GarS family
I6I38_RS22705	COG1515	deoxyribonuclease V activity
I6I38_RS22710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I38_RS22715	COG2816	NAD+ diphosphatase activity
I6I38_RS22720	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6I38_RS22725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I38_RS22730	COG0352	thiamine-phosphate diphosphorylase activity
I6I38_RS22735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I38_RS22740	COG2104	thiamine diphosphate biosynthetic process
I6I38_RS22745	COG2022	thiamine diphosphate biosynthetic process
I6I38_RS22765	COG2205	protein histidine kinase activity
I6I38_RS22780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I38_RS22785	COG0085	RNA polymerase activity
I6I38_RS22790	COG0222	ribosome binding
I6I38_RS22795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I38_RS22800	COG0081	regulation of translation
I6I38_RS22810	COG0250	Participates in transcription elongation, termination and antitermination
I6I38_RS22820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I38_RS22855	COG1072	(Pantothenic acid kinase))
I6I38_RS22860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I38_RS22860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I38_RS22865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I38_RS22895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I38_RS22900	COG1739	Uncharacterized protein family UPF0029
I6I38_RS22905	COG0006	proline dipeptidase activity
I6I38_RS22910	COG2271	Major facilitator Superfamily
I6I38_RS22915	COG1024	Enoyl-CoA hydratase
I6I38_RS22915	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I38_RS22920	COG0183	Belongs to the thiolase family
I6I38_RS22950	COG0084	hydrolase, TatD family'
I6I38_RS22955	COG0805	protein transport
I6I38_RS22965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I38_RS22970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I38_RS22975	COG3165	ubiquinone biosynthetic process from chorismate
I6I38_RS22980	COG2226	methyltransferase
I6I38_RS22985	COG1322	Protein conserved in bacteria
I6I38_RS22990	COG0586	Pfam SNARE associated Golgi protein
I6I38_RS23005	COG0412	Dienelactone hydrolase
I6I38_RS23010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I38_RS23035	COG0584	glycerophosphoryl diester phosphodiesterase
I6I38_RS23040	COG3842	ATPase activity
I6I38_RS23050	COG1175	transmembrane transport
I6I38_RS23055	COG1653	transport
I6I38_RS23060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I38_RS23065	COG0410	ABC transporter
I6I38_RS23080	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS23090	COG0456	acetyltransferase
I6I38_RS23110	COG2177	Part of the ABC transporter FtsEX involved in
I6I38_RS23115	COG2884	Cell division ATP-binding protein ftsE
I6I38_RS23120	COG0552	protein localization to endoplasmic reticulum
I6I38_RS23120	COG0552	protein localization to endoplasmic reticulum
I6I38_RS23125	COG0742	ribosomal rna small subunit methyltransferase
I6I38_RS23130	COG3776	membrane
I6I38_RS23140	COG2197	response regulator
I6I38_RS23155	COG0582	viral genome integration into host DNA
I6I38_RS23170	COG0582	viral genome integration into host DNA
I6I38_RS23175	COG3714	YhhN family
I6I38_RS23210	COG0425	Belongs to the sulfur carrier protein TusA family
I6I38_RS23215	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I38_RS23220	COG0456	acetyltransferase
I6I38_RS23230	COG0247	lactate metabolic process
I6I38_RS23240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I38_RS23245	COG2271	Major facilitator Superfamily
I6I38_RS23250	COG0584	glycerophosphoryl diester phosphodiesterase
I6I38_RS23255	COG0561	phosphatase activity
I6I38_RS23260	COG2267	carboxylic ester hydrolase activity
I6I38_RS23265	COG1280	lysine exporter protein (LysE YggA)
I6I38_RS23270	COG1280	lysine exporter protein (LysE YggA)
I6I38_RS23275	COG0514	ATP-dependent DNA helicase (RecQ)
I6I38_RS23280	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6I38_RS23285	COG2050	protein possibly involved in aromatic compounds catabolism
I6I38_RS23295	COG3180	Ammonia monooxygenase
I6I38_RS23310	COG0210	DNA helicase
I6I38_RS23315	COG1011	Hydrolase
I6I38_RS23325	COG3159	Protein conserved in bacteria
I6I38_RS23330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I38_RS23340	COG1965	Belongs to the frataxin family
I6I38_RS23345	COG3072	Adenylate cyclase
I6I38_RS23350	COG0181	hydroxymethylbilane synthase activity
I6I38_RS23360	COG2959	enzyme of heme biosynthesis
I6I38_RS23365	COG3071	HemY protein
I6I38_RS23405	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6I38_RS23415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I38_RS23420	COG2244	polysaccharide biosynthetic process
I6I38_RS23425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I38_RS23430	COG0456	acetyltransferase
I6I38_RS23435	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I38_RS23440	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I38_RS23445	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I38_RS23450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I38_RS23460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I38_RS23465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I38_RS23470	COG3118	belongs to the thioredoxin family
I6I38_RS23475	COG0513	Belongs to the DEAD box helicase family
I6I38_RS23480	COG0248	Ppx GppA phosphatase
I6I38_RS23490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I38_RS23495	COG0612	Peptidase, M16
I6I38_RS23500	COG1301	dicarboxylic acid transport
I6I38_RS23505	COG2199	diguanylate cyclase activity
I6I38_RS23505	COG2200	EAL domain
I6I38_RS23510	COG0457	Tetratricopeptide repeat
I6I38_RS23510	COG3118	belongs to the thioredoxin family
I6I38_RS23515	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6I38_RS23520	COG1215	transferase activity, transferring glycosyl groups
I6I38_RS23525	COG1215	transferase activity, transferring glycosyl groups
I6I38_RS23550	COG2194	sulfuric ester hydrolase activity
I6I38_RS23555	COG4608	Belongs to the ABC transporter superfamily
I6I38_RS23560	COG0444	Belongs to the ABC transporter superfamily
I6I38_RS23565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I38_RS23570	COG0601	transmembrane transport
I6I38_RS23575	COG0747	negative chemotaxis
I6I38_RS23610	COG2271	Major facilitator Superfamily
I6I38_RS23620	COG2197	response regulator
I6I38_RS23625	COG2194	sulfuric ester hydrolase activity
I6I38_RS23630	COG1764	response to oxidative stress
I6I38_RS23635	COG1846	Transcriptional regulator
I6I38_RS23680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I38_RS23685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I38_RS23690	COG1028	Short-chain dehydrogenase reductase Sdr
I6I38_RS23735	COG2807	transmembrane transport
I6I38_RS23740	COG0583	DNA-binding transcription factor activity
I6I38_RS23745	COG1609	Transcriptional regulator
I6I38_RS23745	COG2207	Transcriptional regulator
I6I38_RS23755	COG1757	Na H antiporter
I6I38_RS23760	COG2115	Belongs to the xylose isomerase family
I6I38_RS23765	COG1070	Carbohydrate kinase
I6I38_RS23770	COG0402	S-adenosylhomocysteine deaminase activity
I6I38_RS23775	COG1335	isochorismatase
I6I38_RS23785	COG3274	enterobacterial common antigen metabolic process
I6I38_RS23795	COG3276	selenocysteine insertion sequence binding
I6I38_RS23800	COG1921	L-seryl-tRNASec selenium transferase activity
I6I38_RS23805	COG0625	glutathione transferase activity
I6I38_RS23815	COG3058	Necessary for formate dehydrogenase activity
I6I38_RS23820	COG2864	formate dehydrogenase
I6I38_RS23825	COG0437	4 iron, 4 sulfur cluster binding
I6I38_RS23840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I38_RS23850	COG2258	MOSC domain
I6I38_RS23865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I38_RS23875	COG3722	fumarate hydratase activity
I6I38_RS23880	COG0246	Mannitol dehydrogenase
I6I38_RS23885	COG2213	PTS system mannitol-specific
I6I38_RS23885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I38_RS23900	COG0751	glycine-tRNA ligase activity
I6I38_RS23905	COG0752	glycyl-tRNA synthetase alpha subunit
I6I38_RS23910	COG2271	Major facilitator Superfamily
I6I38_RS23920	COG2818	Glycosylase
I6I38_RS23925	COG0456	acetyltransferase
I6I38_RS23930	COG2885	chlorophyll binding
I6I38_RS23935	COG1609	Transcriptional regulator
I6I38_RS23945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS23950	COG2814	Major facilitator Superfamily
I6I38_RS23955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I38_RS23970	COG0366	Alpha amylase catalytic
I6I38_RS23975	COG3977	Valine--pyruvate aminotransferase
I6I38_RS23980	COG2985	domain, Protein
I6I38_RS23985	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I38_RS23990	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I38_RS23995	COG5645	(Lipo)protein
I6I38_RS24000	COG0823	Involved in the tonB-independent uptake of proteins
I6I38_RS24005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I38_RS24010	COG2423	ornithine cyclodeaminase activity
I6I38_RS24015	COG0561	phosphatase activity
I6I38_RS24020	COG0187	DNA topoisomerase II activity
I6I38_RS24025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I38_RS24030	COG0592	DNA-directed DNA polymerase activity
I6I38_RS24035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I38_RS24040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I38_RS24045	COG0594	ribonuclease P activity
I6I38_RS24050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I38_RS24055	COG0706	membrane insertase activity
I6I38_RS24060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I38_RS24075	COG2091	lysine biosynthetic process via aminoadipic acid
I6I38_RS24080	COG0431	NADPH-dependent FMN reductase
I6I38_RS24090	COG2252	PERMEase
I6I38_RS24095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I38_RS24100	COG0765	amino acid transport
I6I38_RS24105	COG0765	amino acid transport
I6I38_RS24110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I38_RS24115	COG0704	Plays a role in the regulation of phosphate uptake
I6I38_RS24125	COG0581	inorganic phosphate transmembrane transporter activity
I6I38_RS24130	COG0573	inorganic phosphate transmembrane transporter activity
I6I38_RS24135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I38_RS24145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I38_RS24150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I38_RS24155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I38_RS24160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I38_RS24165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I38_RS24170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I38_RS24175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I38_RS24190	COG3312	ion transport
I6I38_RS24195	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I38_RS24200	COG0445	tRNA wobble uridine modification
I6I38_RS24205	COG0716	FMN binding
I6I38_RS24210	COG1522	sequence-specific DNA binding
I6I38_RS24215	COG2502	aspartate--ammonia ligase
I6I38_RS24220	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6I38_RS24225	COG0714	Associated with various cellular activities
I6I38_RS24230	COG3158	transport of potassium into the cell
I6I38_RS24235	COG1869	D-ribose catabolic process
I6I38_RS24240	COG1129	ABC transporter
I6I38_RS24245	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I38_RS24255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I38_RS24260	COG1609	Transcriptional regulator
I6I38_RS24265	COG0477	Major facilitator Superfamily
I6I38_RS24270	COG2186	Transcriptional regulator
I6I38_RS24295	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I38_RS24300	COG0746	molybdenum cofactor guanylyltransferase activity
I6I38_RS24305	COG3084	Protein conserved in bacteria
I6I38_RS24310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I38_RS24315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I38_RS24320	COG0204	Acyl-transferase
I6I38_RS24325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I38_RS24325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I38_RS24330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I38_RS24335	COG3078	GTPase activator activity
I6I38_RS24340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I38_RS24355	COG3852	Histidine kinase
I6I38_RS24360	COG0174	glutamine synthetase
I6I38_RS24365	COG1217	gtp-binding protein TYPA
I6I38_RS24370	COG1011	Hydrolase
I6I38_RS24375	COG1295	ribonuclease BN
I6I38_RS24380	COG1490	D-aminoacyl-tRNA deacylase activity
I6I38_RS24385	COG0456	acetyltransferase
I6I38_RS24390	COG2982	Protein involved in outer membrane biogenesis
I6I38_RS24395	COG2233	PERMEase
I6I38_RS24400	COG0786	glutamate:sodium symporter activity
I6I38_RS24405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I38_RS24410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I38_RS24415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I38_RS24420	COG1758	RNA polymerase activity
I6I38_RS24425	COG0194	GDP metabolic process
I6I38_RS24435	COG2860	membrane
I6I38_RS24445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I38_RS24450	COG4221	oxidoreductase activity
I6I38_RS24455	COG1561	YicC-like family, N-terminal region
I6I38_RS24460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I38_RS24465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I38_RS24470	COG1309	transcriptional regulator
I6I38_RS24475	COG0756	dUTP diphosphatase activity
I6I38_RS24480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I38_RS24485	COG2003	Belongs to the UPF0758 family
I6I38_RS24490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I38_RS24500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I38_RS24505	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I38_RS24515	COG1519	Transferase
I6I38_RS24525	COG0438	transferase activity, transferring glycosyl groups
I6I38_RS24530	COG0438	transferase activity, transferring glycosyl groups
I6I38_RS24535	COG0859	PFAM glycosyl transferase family 9
I6I38_RS24550	COG1215	transferase activity, transferring glycosyl groups
I6I38_RS24555	COG3307	-O-antigen
I6I38_RS24560	COG0438	transferase activity, transferring glycosyl groups
I6I38_RS24565	COG0859	PFAM glycosyl transferase family 9
I6I38_RS24570	COG0859	PFAM glycosyl transferase family 9
I6I38_RS24575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I38_RS24580	COG0156	8-amino-7-oxononanoate synthase activity
I6I38_RS24585	COG1063	alcohol dehydrogenase
I6I38_RS24590	COG2861	carbohydrate metabolic process
I6I38_RS24595	COG4942	peptidase
I6I38_RS24600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I38_RS24605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I38_RS24610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I38_RS24615	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I38_RS24620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I38_RS24625	COG1045	serine acetyltransferase
I6I38_RS24640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I38_RS24645	COG2205	protein histidine kinase activity
I6I38_RS24650	COG0745	RESPONSE REGULATOR receiver
I6I38_RS24655	COG3678	ATP-independent chaperone mediated protein folding
I6I38_RS24660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I38_RS24665	COG0205	6-phosphofructokinase activity
I6I38_RS24670	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I38_RS24675	COG0149	triose-phosphate isomerase activity
I6I38_RS24685	COG3152	Membrane
I6I38_RS24700	COG2814	Major facilitator Superfamily
I6I38_RS24705	COG1494	fructose-1,6-bisphosphatase
I6I38_RS24715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I38_RS24720	COG3074	FtsZ-dependent cytokinesis
I6I38_RS24725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I38_RS24730	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I38_RS24735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I38_RS24740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I38_RS24745	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I38_RS24750	COG1609	Transcriptional regulator
I6I38_RS24755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I38_RS24760	COG0254	rRNA binding
I6I38_RS24765	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6I38_RS24770	COG0626	cystathionine gamma-synthase activity
I6I38_RS24775	COG0460	homoserine dehydrogenase
I6I38_RS24775	COG0527	aspartate kinase activity
I6I38_RS24780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I38_RS24785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I38_RS24800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I38_RS24805	COG0137	argininosuccinate synthase activity
I6I38_RS24810	COG0165	Argininosuccinate lyase
I6I38_RS24820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I38_RS24825	COG0678	peroxiredoxin activity
I6I38_RS24825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I38_RS24835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I38_RS24865	COG2197	response regulator
I6I38_RS24880	COG1388	LysM domain
I6I38_RS24880	COG1470	cell adhesion involved in biofilm formation
I6I38_RS24915	COG2801	Transposase and inactivated derivatives
I6I38_RS24930	COG0582	viral genome integration into host DNA
I6I38_RS24975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I38_RS25110	COG0582	viral genome integration into host DNA
I6I38_RS25115	COG0582	viral genome integration into host DNA
I6I38_RS25120	COG0582	viral genome integration into host DNA
I6I38_RS25255	COG1192	Involved in chromosome partitioning
I6I38_RS25315	COG4680	protein conserved in bacteria
I6I38_RS25320	COG5499	transcription regulator containing HTH domain
I6I38_RS25495	COG0741	lytic transglycosylase activity
I6I38_RS25510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I38_RS25595	COG1192	Involved in chromosome partitioning
I6I38_RS25625	COG2433	Pfam Transposase IS66
I6I38_RS25635	COG2433	Pfam Transposase IS66
I6I38_RS25700	COG4680	protein conserved in bacteria
I6I38_RS25730	COG0582	viral genome integration into host DNA