locus-tag	class	description
AL485_RS00010	COG0309	Hydrogenase expression formation protein (HypE)
AL485_RS00015	COG0409	Hydrogenase expression formation protein
AL485_RS00020	COG0298	carbon dioxide binding
AL485_RS00025	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AL485_RS00030	COG0375	protein maturation
AL485_RS00040	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL485_RS00045	COG0651	ATP synthesis coupled electron transport
AL485_RS00050	COG0650	Formate hydrogenlyase subunit 4
AL485_RS00055	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AL485_RS00055	COG3261	NADH dehydrogenase
AL485_RS00060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL485_RS00065	COG3260	NADH ubiquinone oxidoreductase 20
AL485_RS00075	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AL485_RS00080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL485_RS00085	COG3383	formate dehydrogenase (NAD+) activity
AL485_RS00090	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AL485_RS00095	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AL485_RS00110	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS00115	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL485_RS00120	COG1802	Transcriptional regulator
AL485_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS00160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AL485_RS00175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL485_RS00180	COG0076	glutamate decarboxylase activity
AL485_RS00230	COG3284	Transcriptional regulator
AL485_RS00240	COG1064	alcohol dehydrogenase
AL485_RS00255	COG1522	sequence-specific DNA binding
AL485_RS00280	COG0583	DNA-binding transcription factor activity
AL485_RS00285	COG2814	Major facilitator Superfamily
AL485_RS00300	COG0673	inositol 2-dehydrogenase activity
AL485_RS00315	COG4558	Periplasmic binding protein
AL485_RS00330	COG2862	Uncharacterized protein family, UPF0114
AL485_RS00350	COG0371	Dehydrogenase
AL485_RS00370	COG2814	Major facilitator Superfamily
AL485_RS00380	COG2814	Major facilitator Superfamily
AL485_RS00390	COG0583	DNA-binding transcription factor activity
AL485_RS00395	COG2079	MmgE PrpD family protein
AL485_RS00400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS00415	COG1126	abc transporter atp-binding protein
AL485_RS00425	COG0768	penicillin binding
AL485_RS00445	COG4608	Belongs to the ABC transporter superfamily
AL485_RS00450	COG0444	Belongs to the ABC transporter superfamily
AL485_RS00455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL485_RS00460	COG0601	transmembrane transport
AL485_RS00465	COG0747	negative chemotaxis
AL485_RS00470	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AL485_RS00485	COG2814	Major facilitator Superfamily
AL485_RS00545	COG0596	Alpha beta hydrolase
AL485_RS00580	COG2723	6-phospho-beta-galactosidase activity
AL485_RS00585	COG1263	PTS System
AL485_RS00585	COG2190	(PTS) system
AL485_RS00585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS00595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL485_RS00595	COG2010	Cytochrome c
AL485_RS00630	COG0583	DNA-binding transcription factor activity
AL485_RS00635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL485_RS00635	COG2010	Cytochrome c
AL485_RS00640	COG2080	2 iron, 2 sulfur cluster binding
AL485_RS00645	COG1846	Transcriptional regulator
AL485_RS00650	COG2309	aminopeptidase activity
AL485_RS00655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL485_RS00660	COG0596	Alpha beta hydrolase
AL485_RS00665	COG3473	Maleate cis-trans isomerase
AL485_RS00670	COG1335	isochorismatase
AL485_RS00675	COG2271	Major facilitator Superfamily
AL485_RS00680	COG0339	signal peptide processing
AL485_RS00690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL485_RS00700	COG0402	S-adenosylhomocysteine deaminase activity
AL485_RS00705	COG1940	carbohydrate kinase activity
AL485_RS00710	COG2182	Extracellular solute-binding protein
AL485_RS00725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL485_RS00730	COG3842	ATPase activity
AL485_RS00735	COG1595	DNA-templated transcription, initiation
AL485_RS00740	COG3712	iron ion homeostasis
AL485_RS00745	COG4772	TonB-dependent receptor
AL485_RS00750	COG0477	Major facilitator Superfamily
AL485_RS00760	COG4221	oxidoreductase activity
AL485_RS00765	COG1742	UPF0060 membrane protein
AL485_RS00780	COG0477	Major facilitator Superfamily
AL485_RS00790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL485_RS00795	COG1940	carbohydrate kinase activity
AL485_RS00800	COG0583	DNA-binding transcription factor activity
AL485_RS00805	COG2814	Major facilitator Superfamily
AL485_RS00820	COG2378	regulation of single-species biofilm formation
AL485_RS00825	COG0114	fumarate hydratase activity
AL485_RS00840	COG5339	Protein conserved in bacteria
AL485_RS00845	COG5339	Protein conserved in bacteria
AL485_RS00850	COG5339	Protein conserved in bacteria
AL485_RS00860	COG0583	DNA-binding transcription factor activity
AL485_RS00870	COG2814	Major facilitator Superfamily
AL485_RS00885	COG1609	Transcriptional regulator
AL485_RS00890	COG1263	PTS System
AL485_RS00890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS00895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL485_RS00905	COG0494	nUDIX hydrolase
AL485_RS00910	COG1349	DNA-binding transcription factor activity
AL485_RS00915	COG0205	6-phosphofructokinase activity
AL485_RS00940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL485_RS00945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL485_RS00950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL485_RS00955	COG0385	Bile acid
AL485_RS00960	COG0673	inositol 2-dehydrogenase activity
AL485_RS00970	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS00975	COG1129	ABC transporter
AL485_RS00980	COG1879	ABC-type sugar transport system periplasmic component
AL485_RS00985	COG1069	ribulokinase activity
AL485_RS00990	COG2160	L-arabinose isomerase activity
AL485_RS01000	COG4657	Part of a membrane complex involved in electron transport
AL485_RS01005	COG2878	Part of a membrane complex involved in electron transport
AL485_RS01010	COG4656	Part of a membrane complex involved in electron transport
AL485_RS01015	COG2207	Transcriptional regulator
AL485_RS01015	COG3708	Transcriptional regulator
AL485_RS01025	COG4659	FMN binding
AL485_RS01035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL485_RS01040	COG3104	oligopeptide transport
AL485_RS01045	COG1505	serine-type exopeptidase activity
AL485_RS01050	COG1396	sequence-specific DNA binding
AL485_RS01055	COG3135	benzoate transporter
AL485_RS01085	COG1418	mRNA catabolic process
AL485_RS01105	COG0625	glutathione transferase activity
AL485_RS01115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL485_RS01120	COG0259	pyridoxamine-phosphate oxidase activity
AL485_RS01125	COG3895	Periplasmic Protein
AL485_RS01130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL485_RS01135	COG3133	Outer membrane lipoprotein
AL485_RS01140	COG1846	Transcriptional regulator
AL485_RS01145	COG1566	PFAM secretion protein HlyD family protein
AL485_RS01150	COG1289	transmembrane transporter activity
AL485_RS01160	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL485_RS01165	COG4989	oxidoreductase activity
AL485_RS01170	COG3313	Fe-S protein
AL485_RS01175	COG0583	DNA-binding transcription factor activity
AL485_RS01180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL485_RS01185	COG2194	sulfuric ester hydrolase activity
AL485_RS01190	COG1309	transcriptional regulator
AL485_RS01195	COG1902	pentaerythritol trinitrate reductase activity
AL485_RS01200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AL485_RS01205	COG0346	lactoylglutathione lyase activity
AL485_RS01215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL485_RS01220	COG0791	NLP P60 protein
AL485_RS01230	COG1609	Transcriptional regulator
AL485_RS01235	COG0583	DNA-binding transcription factor activity
AL485_RS01240	COG2814	Major facilitator Superfamily
AL485_RS01245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL485_RS01255	COG0307	riboflavin synthase, alpha
AL485_RS01260	COG0534	Mate efflux family protein
AL485_RS01285	COG0469	pyruvate kinase activity
AL485_RS01295	COG1376	ErfK ybiS ycfS ynhG family protein
AL485_RS01295	COG1388	LysM domain
AL485_RS01300	COG2166	iron-sulfur cluster assembly
AL485_RS01305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL485_RS01310	COG0719	Fe-S assembly protein
AL485_RS01315	COG0396	ATPase activity
AL485_RS01320	COG0719	Fe-S assembly protein
AL485_RS01325	COG0316	Belongs to the HesB IscA family
AL485_RS01335	COG2050	protein possibly involved in aromatic compounds catabolism
AL485_RS01340	COG0247	lactate metabolic process
AL485_RS01340	COG0277	FAD linked oxidase domain protein
AL485_RS01345	COG0628	permease
AL485_RS01355	COG0574	Belongs to the PEP-utilizing enzyme family
AL485_RS01355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL485_RS01365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL485_RS01370	COG0386	Belongs to the glutathione peroxidase family
AL485_RS01385	COG3720	iron ion transport
AL485_RS01390	COG4558	Periplasmic binding protein
AL485_RS01395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL485_RS01400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL485_RS01415	COG0095	Lipoate-protein ligase
AL485_RS01420	COG0791	NLP P60 protein
AL485_RS01425	COG2076	Multidrug Resistance protein
AL485_RS01430	COG2076	Multidrug Resistance protein
AL485_RS01435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL485_RS01440	COG0726	polysaccharide deacetylase
AL485_RS01445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL485_RS01445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL485_RS01450	COG1215	transferase activity, transferring glycosyl groups
AL485_RS01455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL485_RS01460	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL485_RS01465	COG0386	Belongs to the glutathione peroxidase family
AL485_RS01470	COG4139	cobalamin transport
AL485_RS01480	COG0776	regulation of translation
AL485_RS01490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL485_RS01495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL485_RS01500	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL485_RS01510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL485_RS01540	COG0814	amino acid
AL485_RS01570	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL485_RS01575	COG1121	(ABC) transporter
AL485_RS01580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL485_RS01585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL485_RS01595	COG3001	Fructosamine kinase
AL485_RS01610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL485_RS01615	COG1988	membrane-bound metal-dependent
AL485_RS01620	COG1823	symporter activity
AL485_RS01635	COG2188	Transcriptional regulator
AL485_RS01645	COG2814	Major facilitator Superfamily
AL485_RS01650	COG0501	Belongs to the peptidase M48B family
AL485_RS01660	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL485_RS01665	COG1956	GAF domain-containing protein
AL485_RS01670	COG2995	paraquat-inducible protein a
AL485_RS01675	COG3008	intermembrane lipid transfer
AL485_RS01680	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AL485_RS01680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL485_RS01735	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL485_RS01740	COG3493	citrate carrier protein
AL485_RS01745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL485_RS01765	COG0477	Major facilitator Superfamily
AL485_RS01770	COG2211	Major facilitator Superfamily
AL485_RS01790	COG0402	S-adenosylhomocysteine deaminase activity
AL485_RS01800	COG1228	amidohydrolase
AL485_RS01815	COG1605	Chorismate mutase
AL485_RS01850	COG0531	amino acid
AL485_RS01855	COG0174	glutamine synthetase
AL485_RS01860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL485_RS01865	COG1917	Cupin 2, conserved barrel domain protein
AL485_RS01865	COG1396	sequence-specific DNA binding
AL485_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS01875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL485_RS01880	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS01885	COG0589	response to stress
AL485_RS01890	COG1335	isochorismatase
AL485_RS01895	COG1278	Cold shock
AL485_RS01915	COG0673	inositol 2-dehydrogenase activity
AL485_RS01950	COG0628	permease
AL485_RS01960	COG0583	DNA-binding transcription factor activity
AL485_RS01965	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS01975	COG2963	transposase activity
AL485_RS01980	COG2801	Transposase and inactivated derivatives
AL485_RS02000	COG0538	isocitrate dehydrogenase activity
AL485_RS02005	COG1187	pseudouridine synthase activity
AL485_RS02020	COG0482	sulfurtransferase activity
AL485_RS02025	COG2915	High frequency lysogenization protein hflD homolog
AL485_RS02030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL485_RS02065	COG0745	RESPONSE REGULATOR receiver
AL485_RS02075	COG2850	peptidyl-arginine hydroxylation
AL485_RS02080	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AL485_RS02085	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL485_RS02090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS02090	COG1263	PTS System
AL485_RS02095	COG1486	melibiose metabolic process
AL485_RS02115	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL485_RS02125	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL485_RS02140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL485_RS02145	COG3706	GGDEF domain
AL485_RS02150	COG4702	Belongs to the UPF0303 family
AL485_RS02155	COG0659	secondary active sulfate transmembrane transporter activity
AL485_RS02175	COG2890	protein-(glutamine-N5) methyltransferase activity
AL485_RS02180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL485_RS02185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL485_RS02190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL485_RS02195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL485_RS02200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL485_RS02210	COG0193	aminoacyl-tRNA hydrolase activity
AL485_RS02215	COG0659	secondary active sulfate transmembrane transporter activity
AL485_RS02220	COG0012	GTP binding
AL485_RS02225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL485_RS02235	COG0740	serine-type endopeptidase activity
AL485_RS02250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL485_RS02255	COG2313	pseudouridylate synthase activity
AL485_RS02260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL485_RS02265	COG0531	amino acid
AL485_RS02270	COG2731	YhcH YjgK YiaL family protein
AL485_RS02275	COG3250	beta-galactosidase activity
AL485_RS02280	COG1609	Transcriptional regulator
AL485_RS02290	COG3408	Glycogen debranching enzyme
AL485_RS02290	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AL485_RS02295	COG0589	response to stress
AL485_RS02300	COG1858	cytochrome C peroxidase
AL485_RS02330	COG1464	Belongs to the NlpA lipoprotein family
AL485_RS02350	COG0579	oxidoreductase
AL485_RS02360	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS02365	COG1129	ABC transporter
AL485_RS02380	COG3290	protein histidine kinase activity
AL485_RS02385	COG4565	transcriptional regulatory protein
AL485_RS02410	COG3655	Transcriptional regulator
AL485_RS02420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL485_RS02495	COG2801	Transposase and inactivated derivatives
AL485_RS02500	COG2963	transposase activity
AL485_RS02535	COG4725	Belongs to the MT-A70-like family
AL485_RS02670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL485_RS02675	COG2135	peptidase activity
AL485_RS02695	COG0582	viral genome integration into host DNA
AL485_RS02705	COG1276	copper resistance
AL485_RS02710	COG2372	response to copper ion
AL485_RS02715	COG1528	Iron-storage protein
AL485_RS02735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL485_RS02740	COG1770	oligopeptidase
AL485_RS02745	COG2979	Protein of unknown function (DUF533)
AL485_RS02750	COG3381	protein complex oligomerization
AL485_RS02755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL485_RS02760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL485_RS02780	COG3708	Transcriptional regulator
AL485_RS02780	COG2207	Transcriptional regulator
AL485_RS02785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS02805	COG1252	NADH dehydrogenase
AL485_RS02810	COG3150	esterase
AL485_RS02820	COG0510	thiamine kinase activity
AL485_RS02825	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AL485_RS02830	COG5633	Lipoprotein
AL485_RS02835	COG0537	adenosine 5'-monophosphoramidase activity
AL485_RS02840	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL485_RS02845	COG1733	regulation of RNA biosynthetic process
AL485_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS02860	COG0583	DNA-binding transcription factor activity
AL485_RS02870	COG1914	H( )-stimulated, divalent metal cation uptake system
AL485_RS02875	COG1321	iron dependent repressor
AL485_RS02885	COG1263	PTS System
AL485_RS02885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS02890	COG0084	hydrolase, TatD family'
AL485_RS02895	COG0470	DNA polymerase III
AL485_RS02900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL485_RS02905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL485_RS02910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL485_RS02915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL485_RS02920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL485_RS02935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL485_RS02940	COG0416	fatty acid biosynthetic process
AL485_RS02945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL485_RS02960	COG0564	pseudouridine synthase activity
AL485_RS02965	COG1530	ribonuclease E activity
AL485_RS02970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL485_RS02975	COG0418	dihydroorotase activity
AL485_RS03010	COG0628	permease
AL485_RS03015	COG3038	cytochrome b561
AL485_RS03020	COG2353	YceI-like domain
AL485_RS03025	COG1054	Belongs to the UPF0176 family
AL485_RS03030	COG1902	pentaerythritol trinitrate reductase activity
AL485_RS03040	COG1560	Kdo2-lipid A biosynthetic process
AL485_RS03050	COG2814	Major facilitator Superfamily
AL485_RS03060	COG0346	lactoylglutathione lyase activity
AL485_RS03075	COG0640	Transcriptional regulator
AL485_RS03085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL485_RS03100	COG5645	(Lipo)protein
AL485_RS03105	COG2943	transferase activity, transferring hexosyl groups
AL485_RS03110	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AL485_RS03140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS03165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL485_RS03170	COG1486	melibiose metabolic process
AL485_RS03175	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL485_RS03180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL485_RS03215	COG0322	excinuclease ABC activity
AL485_RS03220	COG2197	response regulator
AL485_RS03230	COG3136	membrane protein required for alginate biosynthesis
AL485_RS03270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL485_RS03275	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS03280	COG0531	amino acid
AL485_RS03295	COG2197	response regulator
AL485_RS03300	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL485_RS03305	COG0183	Belongs to the thiolase family
AL485_RS03310	COG0156	8-amino-7-oxononanoate synthase activity
AL485_RS03315	COG2814	Major facilitator Superfamily
AL485_RS03320	COG1024	Enoyl-CoA hydratase
AL485_RS03330	COG2271	Major facilitator Superfamily
AL485_RS03335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AL485_RS03345	COG3064	Membrane
AL485_RS03355	COG0322	excinuclease ABC activity
AL485_RS03375	COG1113	amino acid transport
AL485_RS03380	COG1309	transcriptional regulator
AL485_RS03385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS03390	COG1335	isochorismatase
AL485_RS03395	COG0251	oxidation-reduction process
AL485_RS03400	COG2267	carboxylic ester hydrolase activity
AL485_RS03405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL485_RS03410	COG2233	PERMEase
AL485_RS03435	COG1280	lysine exporter protein (LysE YggA)
AL485_RS03440	COG0655	NAD(P)H dehydrogenase (quinone) activity
AL485_RS03450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL485_RS03480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL485_RS03490	COG0670	Belongs to the BI1 family
AL485_RS03495	COG2920	part of a sulfur-relay system
AL485_RS03500	COG1254	Belongs to the acylphosphatase family
AL485_RS03505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL485_RS03510	COG3785	DNA binding
AL485_RS03515	COG1832	CoA-binding protein
AL485_RS03525	COG1803	Methylglyoxal synthase
AL485_RS03530	COG0210	DNA helicase
AL485_RS03535	COG3304	Inner membrane component domain
AL485_RS03540	COG1289	transmembrane transporter activity
AL485_RS03545	COG3070	regulator of competence-specific genes
AL485_RS03550	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
AL485_RS03560	COG3120	sequence-specific DNA binding
AL485_RS03565	COG1067	ATP-dependent peptidase activity
AL485_RS03570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL485_RS03580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL485_RS03585	COG3009	Protein conserved in bacteria
AL485_RS03590	COG3008	intermembrane lipid transfer
AL485_RS03590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL485_RS03595	COG2995	paraquat-inducible protein a
AL485_RS03600	COG0488	(ABC) transporter
AL485_RS03605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL485_RS03605	COG0116	Belongs to the methyltransferase superfamily
AL485_RS03610	COG3217	Mosc domain protein beta barrel domain protein
AL485_RS03610	COG0633	Ferredoxin
AL485_RS03620	COG0167	dihydroorotate dehydrogenase activity
AL485_RS03625	COG0431	NADPH-dependent FMN reductase
AL485_RS03630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL485_RS03635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS03640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL485_RS03650	COG0308	aminopeptidase N
AL485_RS03655	COG3706	GGDEF domain
AL485_RS03660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL485_RS03665	COG0017	Asparaginyl-tRNA synthetase
AL485_RS03675	COG1448	Aminotransferase
AL485_RS03680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL485_RS03685	COG3108	Peptidase M15
AL485_RS03690	COG2989	Protein conserved in bacteria
AL485_RS03695	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL485_RS03705	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL485_RS03710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL485_RS03720	COG3173	Aminoglycoside phosphotransferase
AL485_RS03725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL485_RS03730	COG2835	tetraacyldisaccharide 4'-kinase activity
AL485_RS03735	COG3214	Protein conserved in bacteria
AL485_RS03740	COG1278	Cold shock
AL485_RS03750	COG5383	Protein conserved in bacteria
AL485_RS03755	COG1663	tetraacyldisaccharide 4'-kinase activity
AL485_RS03765	COG0658	competence protein
AL485_RS03765	COG2333	competence protein COMEC
AL485_RS03770	COG0776	regulation of translation
AL485_RS03775	COG0539	negative regulation of cytoplasmic translation
AL485_RS03780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL485_RS03785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL485_RS03790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL485_RS03795	COG0252	asparaginase activity
AL485_RS03800	COG1944	ATP diphosphatase activity
AL485_RS03805	COG2116	formate transmembrane transporter activity
AL485_RS03810	COG1882	Formate acetyltransferase
AL485_RS03815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL485_RS03825	COG3381	protein complex oligomerization
AL485_RS03835	COG0437	4 iron, 4 sulfur cluster binding
AL485_RS03845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL485_RS03850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL485_RS03855	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL485_RS03860	COG1674	ftsk spoiiie
AL485_RS03860	COG3107	peptidoglycan biosynthetic process
AL485_RS03870	COG0492	ferredoxin-NADP+ reductase activity
AL485_RS03875	COG0583	DNA-binding transcription factor activity
AL485_RS03885	COG4988	ABC transporter
AL485_RS03890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL485_RS03895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL485_RS03900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL485_RS03905	COG0542	response to heat
AL485_RS03910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL485_RS03915	COG1278	Cold shock
AL485_RS03925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS03930	COG2990	Protein conserved in bacteria
AL485_RS03935	COG3593	DNA synthesis involved in DNA repair
AL485_RS03940	COG2431	L-lysine efflux transmembrane transporter activity
AL485_RS03945	COG1151	hydroxylamine reductase activity
AL485_RS03950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL485_RS03955	COG0028	Belongs to the TPP enzyme family
AL485_RS03960	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL485_RS03970	COG0702	epimerase
AL485_RS03975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL485_RS03980	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL485_RS03985	COG3064	Membrane
AL485_RS03990	COG0393	Putative heavy-metal-binding
AL485_RS04000	COG1126	abc transporter atp-binding protein
AL485_RS04005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS04010	COG4215	(ABC) transporter
AL485_RS04015	COG4160	amino acid transport
AL485_RS04020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS04025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL485_RS04035	COG1177	transmembrane transport
AL485_RS04040	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL485_RS04045	COG3842	ATPase activity
AL485_RS04050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL485_RS04060	COG0189	ligase activity
AL485_RS04080	COG2985	domain, Protein
AL485_RS04080	COG0569	domain protein
AL485_RS04085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL485_RS04090	COG4574	serine-type endopeptidase inhibitor activity
AL485_RS04105	COG0671	phosphoesterase, PA-phosphatase related
AL485_RS04115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL485_RS04120	COG1349	DNA-binding transcription factor activity
AL485_RS04125	COG0814	amino acid
AL485_RS04130	COG1760	l-serine dehydratase
AL485_RS04135	COG1686	Belongs to the peptidase S11 family
AL485_RS04160	COG0625	glutathione transferase activity
AL485_RS04165	COG2133	pyrroloquinoline quinone binding
AL485_RS04175	COG0598	Magnesium transport protein CorA
AL485_RS04180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL485_RS04195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL485_RS04200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL485_RS04210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL485_RS04225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL485_RS04230	COG0107	imidazoleglycerol-phosphate synthase activity
AL485_RS04235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL485_RS04235	COG0140	phosphoribosyl-ATP diphosphatase activity
AL485_RS04240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL485_RS04270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL485_RS04320	COG0438	transferase activity, transferring glycosyl groups
AL485_RS04325	COG2244	polysaccharide biosynthetic process
AL485_RS04370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL485_RS04375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL485_RS04380	COG1253	flavin adenine dinucleotide binding
AL485_RS04385	COG3069	C4-dicarboxylate transmembrane transporter activity
AL485_RS04390	COG2982	Protein involved in outer membrane biogenesis
AL485_RS04395	COG0717	Belongs to the dCTP deaminase family
AL485_RS04400	COG0572	uridine kinase
AL485_RS04410	COG0489	protein tyrosine kinase activity
AL485_RS04415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL485_RS04415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL485_RS04420	COG2814	Major facilitator Superfamily
AL485_RS04425	COG1380	Effector of murein hydrolase LrgA
AL485_RS04430	COG1346	cytolysis
AL485_RS04435	COG0295	cytidine deaminase activity
AL485_RS04440	COG0281	malic enzyme
AL485_RS04445	COG2949	membrane
AL485_RS04465	COG1609	Transcriptional regulator
AL485_RS04470	COG2311	Membrane
AL485_RS04475	COG0302	gtp cyclohydrolase
AL485_RS04480	COG0477	Major facilitator Superfamily
AL485_RS04485	COG0583	DNA-binding transcription factor activity
AL485_RS04515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL485_RS04520	COG0601	transmembrane transport
AL485_RS04525	COG0747	negative chemotaxis
AL485_RS04530	COG4172	Belongs to the ABC transporter superfamily
AL485_RS04545	COG0303	'Molybdopterin
AL485_RS04550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL485_RS04555	COG0488	(ABC) transporter
AL485_RS04570	COG0288	reversible hydration of carbon dioxide
AL485_RS04575	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AL485_RS04595	COG0640	Transcriptional regulator
AL485_RS04600	COG0625	glutathione transferase activity
AL485_RS04620	COG0579	oxidoreductase
AL485_RS04625	COG2207	Transcriptional regulator
AL485_RS04625	COG3708	Transcriptional regulator
AL485_RS04635	COG3188	usher protein
AL485_RS04640	COG3121	Chaperone
AL485_RS04650	COG2200	EAL domain
AL485_RS04660	COG0069	glutamate synthase activity
AL485_RS04665	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AL485_RS04670	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS04675	COG1309	transcriptional regulator
AL485_RS04680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL485_RS04695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL485_RS04700	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AL485_RS04705	COG0745	RESPONSE REGULATOR receiver
AL485_RS04710	COG5002	protein histidine kinase activity
AL485_RS04725	COG3188	usher protein
AL485_RS04765	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AL485_RS04770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL485_RS04775	COG1349	DNA-binding transcription factor activity
AL485_RS04780	COG2084	Dehydrogenase
AL485_RS04785	COG3395	kinase activity
AL485_RS04790	COG0235	Class ii aldolase
AL485_RS04795	COG3622	Belongs to the hyi family
AL485_RS04800	COG2610	gluconate transmembrane transporter activity
AL485_RS04815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL485_RS04820	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AL485_RS04830	COG2731	YhcH YjgK YiaL family protein
AL485_RS04840	COG0783	Belongs to the Dps family
AL485_RS04845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL485_RS04855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS04860	COG0765	amino acid transport
AL485_RS04865	COG1126	abc transporter atp-binding protein
AL485_RS04870	COG0668	transmembrane transport
AL485_RS04900	COG3121	Chaperone
AL485_RS04930	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AL485_RS04935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL485_RS04950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL485_RS04960	COG0477	Major facilitator Superfamily
AL485_RS04970	COG1280	lysine exporter protein (LysE YggA)
AL485_RS04975	COG0583	DNA-binding transcription factor activity
AL485_RS04980	COG2814	Major facilitator Superfamily
AL485_RS04985	COG0697	spore germination
AL485_RS04990	COG1522	sequence-specific DNA binding
AL485_RS04995	COG1199	ATP-dependent helicase activity
AL485_RS05020	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AL485_RS05045	COG0697	spore germination
AL485_RS05065	COG1174	glycine betaine transport
AL485_RS05070	COG1125	glycine betaine transport
AL485_RS05075	COG1174	glycine betaine transport
AL485_RS05080	COG1732	Glycine betaine
AL485_RS05090	COG1051	belongs to the nudix hydrolase family
AL485_RS05100	COG0583	DNA-binding transcription factor activity
AL485_RS05105	COG1335	isochorismatase
AL485_RS05115	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AL485_RS05125	COG0625	glutathione transferase activity
AL485_RS05135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL485_RS05140	COG4221	oxidoreductase activity
AL485_RS05155	COG1683	Conserved Protein
AL485_RS05165	COG2897	thiosulfate sulfurtransferase activity
AL485_RS05170	COG0583	DNA-binding transcription factor activity
AL485_RS05175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL485_RS05185	COG3511	phospholipase C
AL485_RS05225	COG1802	Transcriptional regulator
AL485_RS05245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS05260	COG0840	transmembrane signaling receptor activity
AL485_RS05265	COG4807	Protein conserved in bacteria
AL485_RS05285	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AL485_RS05295	COG1063	alcohol dehydrogenase
AL485_RS05300	COG1802	Transcriptional regulator
AL485_RS05305	COG2271	Major facilitator Superfamily
AL485_RS05315	COG0583	DNA-binding transcription factor activity
AL485_RS05325	COG2084	Dehydrogenase
AL485_RS05330	COG1335	isochorismatase
AL485_RS05350	COG0583	DNA-binding transcription factor activity
AL485_RS05360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL485_RS05365	COG2011	ABC-type metal ion transport system permease component
AL485_RS05370	COG1464	Belongs to the NlpA lipoprotein family
AL485_RS05375	COG1309	transcriptional regulator
AL485_RS05410	COG0366	Alpha amylase catalytic
AL485_RS05435	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL485_RS05440	COG1070	Carbohydrate kinase
AL485_RS05445	COG2814	Major facilitator Superfamily
AL485_RS05465	COG1192	Involved in chromosome partitioning
AL485_RS05480	COG1120	ATPase activity
AL485_RS05485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL485_RS05490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL485_RS05495	COG1472	Belongs to the glycosyl hydrolase 3 family
AL485_RS05505	COG0436	Aminotransferase
AL485_RS05515	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL485_RS05530	COG0277	FAD linked oxidase domain protein
AL485_RS05535	COG0840	transmembrane signaling receptor activity
AL485_RS05570	COG1464	Belongs to the NlpA lipoprotein family
AL485_RS05580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL485_RS05595	COG2354	Protein conserved in bacteria
AL485_RS05605	COG4566	intracellular signal transduction
AL485_RS05610	COG4191	Histidine kinase
AL485_RS05625	COG1686	Belongs to the peptidase S11 family
AL485_RS05630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AL485_RS05635	COG4977	sequence-specific DNA binding
AL485_RS05645	COG0586	Pfam SNARE associated Golgi protein
AL485_RS05650	COG1280	lysine exporter protein (LysE YggA)
AL485_RS05655	COG0583	DNA-binding transcription factor activity
AL485_RS05675	COG0583	DNA-binding transcription factor activity
AL485_RS05690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL485_RS05715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL485_RS05720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL485_RS05745	COG0513	Belongs to the DEAD box helicase family
AL485_RS05750	COG1309	transcriptional regulator
AL485_RS05755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS05760	COG1131	(ABC) transporter
AL485_RS05765	COG0842	Transport permease protein
AL485_RS05770	COG0842	Transport permease protein
AL485_RS05775	COG0670	Belongs to the BI1 family
AL485_RS05780	COG0314	molybdopterin synthase activity
AL485_RS05785	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL485_RS05790	COG0315	cyclic pyranopterin monophosphate synthase activity
AL485_RS05795	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL485_RS05800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL485_RS05805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL485_RS05810	COG4628	conserved protein (DUF2132)
AL485_RS05815	COG0556	nucleotide-excision repair
AL485_RS05835	COG0156	8-amino-7-oxononanoate synthase activity
AL485_RS05840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL485_RS05855	COG1881	PFAM PEBP family protein
AL485_RS05860	COG2706	6-phosphogluconolactonase activity
AL485_RS05865	COG0561	phosphatase activity
AL485_RS05875	COG4149	molybdate abc transporter
AL485_RS05880	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL485_RS05885	COG1120	ATPase activity
AL485_RS05890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL485_RS05895	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL485_RS05905	COG4774	siderophore transport
AL485_RS05910	COG3585	molybdate ion transport
AL485_RS05910	COG2005	Transcriptional regulator
AL485_RS05915	COG1119	ATPase activity
AL485_RS05930	COG1085	galactose-1-phosphate uridylyltransferase
AL485_RS05935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL485_RS05940	COG2017	converts alpha-aldose to the beta-anomer
AL485_RS05950	COG0588	phosphoglycerate mutase activity
AL485_RS05960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL485_RS05965	COG2197	response regulator
AL485_RS05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS05970	COG2205	protein histidine kinase activity
AL485_RS05975	COG1230	cation diffusion facilitator family transporter
AL485_RS05985	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL485_RS06025	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL485_RS06030	COG2885	chlorophyll binding
AL485_RS06035	COG0823	Involved in the tonB-independent uptake of proteins
AL485_RS06040	COG3064	Membrane
AL485_RS06045	COG0848	biopolymer transport protein
AL485_RS06050	COG0811	peptide transport
AL485_RS06055	COG0824	Thioesterase
AL485_RS06060	COG3790	cyd operon protein YbgE
AL485_RS06065	COG4890	Cyd operon protein YbgT
AL485_RS06070	COG1294	oxidase, subunit
AL485_RS06075	COG1271	oxidase subunit
AL485_RS06080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL485_RS06085	COG0045	succinate-CoA ligase (ADP-forming) activity
AL485_RS06090	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL485_RS06095	COG0567	Dehydrogenase, E1 component
AL485_RS06100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL485_RS06110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL485_RS06145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL485_RS06150	COG1984	allophanate hydrolase subunit 2
AL485_RS06155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL485_RS06160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL485_RS06165	COG5212	phosphodiesterase
AL485_RS06175	COG3272	Protein of unknown function (DUF1722)
AL485_RS06190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AL485_RS06195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AL485_RS06200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AL485_RS06205	COG2205	protein histidine kinase activity
AL485_RS06210	COG0745	RESPONSE REGULATOR receiver
AL485_RS06220	COG1695	Transcriptional regulator
AL485_RS06225	COG0033	Phosphoglucomutase
AL485_RS06230	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL485_RS06235	COG0596	Alpha beta hydrolase
AL485_RS06250	COG0735	belongs to the Fur family
AL485_RS06270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL485_RS06280	COG0363	glucosamine-6-phosphate deaminase activity
AL485_RS06285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL485_RS06290	COG1846	Transcriptional regulator
AL485_RS06290	COG1940	carbohydrate kinase activity
AL485_RS06295	COG0647	UMP catabolic process
AL485_RS06300	COG3469	chitinase activity
AL485_RS06305	COG0367	asparagine synthase
AL485_RS06340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL485_RS06345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL485_RS06350	COG2824	Alkylphosphonate utilization operon protein PhnA
AL485_RS06355	COG1702	phosphate starvation-inducible protein PhoH
AL485_RS06360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL485_RS06365	COG4535	Mg2 and Co2 transporter CorC
AL485_RS06370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL485_RS06380	COG0765	amino acid transport
AL485_RS06385	COG0765	amino acid transport
AL485_RS06390	COG1126	abc transporter atp-binding protein
AL485_RS06395	COG1957	nucleoside hydrolase
AL485_RS06405	COG2888	peptidyl-tyrosine sulfation
AL485_RS06410	COG0495	leucyl-tRNA aminoacylation
AL485_RS06415	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL485_RS06420	COG1466	dna polymerase III delta subunit
AL485_RS06425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL485_RS06430	COG0799	negative regulation of ribosome biogenesis
AL485_RS06435	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL485_RS06440	COG0768	penicillin binding
AL485_RS06445	COG0772	Belongs to the SEDS family
AL485_RS06450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL485_RS06455	COG1686	Belongs to the peptidase S11 family
AL485_RS06460	COG2921	Belongs to the UPF0250 family
AL485_RS06465	COG0321	lipoyl(octanoyl) transferase activity
AL485_RS06470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL485_RS06480	COG3706	GGDEF domain
AL485_RS06485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL485_RS06495	COG2814	Major facilitator Superfamily
AL485_RS06505	COG1473	amidohydrolase
AL485_RS06510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS06515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS06525	COG0765	amino acid transport
AL485_RS06530	COG1126	abc transporter atp-binding protein
AL485_RS06540	COG1278	Cold shock
AL485_RS06545	COG2199	diguanylate cyclase activity
AL485_RS06555	COG0583	DNA-binding transcription factor activity
AL485_RS06560	COG0667	Aldo Keto reductase
AL485_RS06565	COG2814	Major facilitator Superfamily
AL485_RS06585	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AL485_RS06590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL485_RS06605	COG1917	Cupin 2, conserved barrel domain protein
AL485_RS06625	COG0604	alcohol dehydrogenase
AL485_RS06630	COG0604	alcohol dehydrogenase
AL485_RS06640	COG2259	Doxx family
AL485_RS06675	COG2003	Belongs to the UPF0758 family
AL485_RS06700	COG3596	GTP binding
AL485_RS06715	COG4983	Phage plasmid primase, P4 family domain protein
AL485_RS06735	COG0737	Belongs to the 5'-nucleotidase family
AL485_RS06745	COG0737	Belongs to the 5'-nucleotidase family
AL485_RS06780	COG0859	PFAM glycosyl transferase family 9
AL485_RS06805	COG3539	Fimbrial protein
AL485_RS06815	COG3121	Chaperone
AL485_RS06820	COG3188	usher protein
AL485_RS06855	COG0582	viral genome integration into host DNA
AL485_RS06870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL485_RS06875	COG2501	S4 domain
AL485_RS06880	COG0215	cysteine-tRNA ligase activity
AL485_RS06885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL485_RS06890	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL485_RS06895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL485_RS06900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL485_RS06910	COG2814	Major facilitator Superfamily
AL485_RS06915	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL485_RS06920	COG4181	ATPase activity
AL485_RS06925	COG2755	lipolytic protein G-D-S-L family
AL485_RS06930	COG0300	oxidoreductase activity
AL485_RS06935	COG3118	belongs to the thioredoxin family
AL485_RS06940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL485_RS06945	COG0330	HflC and HflK could
AL485_RS06950	COG1585	Membrane protein implicated in regulation of membrane protease activity
AL485_RS06955	COG0789	Transcriptional regulator
AL485_RS06960	COG2217	Heavy metal translocating P-type atpase
AL485_RS06965	COG3735	TraB family
AL485_RS06970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL485_RS06975	COG2020	methyltransferase activity
AL485_RS06980	COG0737	Belongs to the 5'-nucleotidase family
AL485_RS06985	COG2223	nitrite transmembrane transporter activity
AL485_RS06990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL485_RS06990	COG4651	solute:proton antiporter activity
AL485_RS06995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL485_RS07000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL485_RS07005	COG1929	Belongs to the glycerate kinase type-1 family
AL485_RS07010	COG2610	gluconate transmembrane transporter activity
AL485_RS07015	COG3835	regulator
AL485_RS07020	COG0563	adenylate kinase activity
AL485_RS07025	COG0326	Molecular chaperone. Has ATPase activity
AL485_RS07030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL485_RS07035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL485_RS07040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL485_RS07045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL485_RS07050	COG2832	Protein of unknown function (DUF454)
AL485_RS07065	COG3264	Mechanosensitive ion channel
AL485_RS07065	COG1196	nuclear chromosome segregation
AL485_RS07070	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL485_RS07075	COG1309	transcriptional regulator
AL485_RS07080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS07085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL485_RS07090	COG0254	rRNA binding
AL485_RS07095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL485_RS07100	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL485_RS07105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL485_RS07110	COG1121	(ABC) transporter
AL485_RS07135	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AL485_RS07140	COG2252	PERMEase
AL485_RS07150	COG3695	enzyme binding
AL485_RS07155	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL485_RS07160	COG1946	Acyl-CoA thioesterase
AL485_RS07170	COG0688	phosphatidylethanolamine metabolic process
AL485_RS07175	COG2258	MOSC domain
AL485_RS07180	COG0004	ammonium transporteR
AL485_RS07185	COG0347	Belongs to the P(II) protein family
AL485_RS07190	COG1132	(ABC) transporter
AL485_RS07195	COG1132	(ABC) transporter
AL485_RS07200	COG1522	sequence-specific DNA binding
AL485_RS07205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL485_RS07210	COG0561	phosphatase activity
AL485_RS07215	COG4533	DNA binding
AL485_RS07220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL485_RS07225	COG0824	Thioesterase
AL485_RS07230	COG1555	photosystem II stabilization
AL485_RS07235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL485_RS07245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL485_RS07250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL485_RS07260	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL485_RS07265	COG0271	Belongs to the BolA IbaG family
AL485_RS07270	COG3056	Lipoprotein
AL485_RS07275	COG2223	nitrite transmembrane transporter activity
AL485_RS07280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL485_RS07285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL485_RS07290	COG1845	cytochrome c oxidase, subunit III
AL485_RS07295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL485_RS07300	COG0109	protoheme IX farnesyltransferase activity
AL485_RS07305	COG2814	Major facilitator Superfamily
AL485_RS07310	COG1666	GTP binding
AL485_RS07315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL485_RS07320	COG0693	protein deglycase activity
AL485_RS07325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL485_RS07325	COG0301	tRNA thio-modification
AL485_RS07330	COG1722	exodeoxyribonuclease VII activity
AL485_RS07335	COG0142	geranyltranstransferase activity
AL485_RS07340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL485_RS07345	COG0667	Aldo Keto reductase
AL485_RS07350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL485_RS07355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL485_RS07360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL485_RS07365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL485_RS07370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL485_RS07370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL485_RS07375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL485_RS07380	COG4238	major outer membrane lipoprotein
AL485_RS07410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL485_RS07415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL485_RS07420	COG1862	Preprotein translocase
AL485_RS07425	COG0343	queuine tRNA-ribosyltransferase activity
AL485_RS07430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL485_RS07435	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL485_RS07440	COG0450	alkyl hydroperoxide reductase
AL485_RS07450	COG0366	Alpha amylase catalytic
AL485_RS07455	COG0668	transmembrane transport
AL485_RS07475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL485_RS07485	COG5002	protein histidine kinase activity
AL485_RS07490	COG0745	RESPONSE REGULATOR receiver
AL485_RS07495	COG0420	3'-5' exonuclease activity
AL485_RS07500	COG0419	ATPase involved in DNA repair
AL485_RS07510	COG1940	carbohydrate kinase activity
AL485_RS07525	COG0191	fructose-bisphosphate aldolase activity
AL485_RS07540	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS07545	COG1129	ABC transporter
AL485_RS07555	COG2974	May be involved in recombination
AL485_RS07560	COG3123	guanosine phosphorylase activity
AL485_RS07565	COG4126	flavin adenine dinucleotide binding
AL485_RS07580	COG1414	Transcriptional regulator
AL485_RS07605	COG0667	Aldo Keto reductase
AL485_RS07610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL485_RS07660	COG2226	methyltransferase
AL485_RS07670	COG3416	Protein conserved in bacteria
AL485_RS07685	COG3011	Protein conserved in bacteria
AL485_RS07695	COG1335	isochorismatase
AL485_RS07710	COG0346	lactoylglutathione lyase activity
AL485_RS07715	COG1349	DNA-binding transcription factor activity
AL485_RS07745	COG3961	Belongs to the TPP enzyme family
AL485_RS07785	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS07790	COG2207	Transcriptional regulator
AL485_RS07800	COG3391	amine dehydrogenase activity
AL485_RS07805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL485_RS07810	COG1629	transport
AL485_RS07810	COG4774	siderophore transport
AL485_RS07815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL485_RS07820	COG2226	methyltransferase
AL485_RS07820	COG3433	isochorismatase activity
AL485_RS07820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL485_RS07835	COG0747	negative chemotaxis
AL485_RS07840	COG3038	cytochrome b561
AL485_RS07855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL485_RS07860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL485_RS07870	COG1073	alpha beta
AL485_RS07875	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL485_RS07880	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL485_RS07885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL485_RS07890	COG0584	glycerophosphoryl diester phosphodiesterase
AL485_RS07895	COG2991	Protein conserved in bacteria
AL485_RS07900	COG1477	protein flavinylation
AL485_RS07905	COG2871	sodium ion transport
AL485_RS07910	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL485_RS07915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL485_RS07920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL485_RS07925	COG1805	sodium ion transport
AL485_RS07930	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL485_RS07935	COG3034	peptidoglycan biosynthetic process
AL485_RS07940	COG0121	glutamine amidotransferase
AL485_RS07945	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL485_RS07950	COG1960	acyl-CoA dehydrogenase activity
AL485_RS07960	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AL485_RS07965	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AL485_RS07970	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AL485_RS07975	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AL485_RS07980	COG0235	Class ii aldolase
AL485_RS07985	COG0436	Aminotransferase
AL485_RS08000	COG2351	hydroxyisourate hydrolase activity
AL485_RS08015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL485_RS08020	COG1126	abc transporter atp-binding protein
AL485_RS08025	COG0765	amino acid transport
AL485_RS08075	COG2375	cellular response to nickel ion
AL485_RS08125	COG1953	Uracil, thiamine, allantoin
AL485_RS08135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL485_RS08140	COG0328	RNA-DNA hybrid ribonuclease activity
AL485_RS08145	COG2226	methyltransferase
AL485_RS08150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL485_RS08155	COG0741	lytic transglycosylase activity
AL485_RS08155	COG1388	LysM domain
AL485_RS08165	COG2814	Major facilitator Superfamily
AL485_RS08170	COG0583	DNA-binding transcription factor activity
AL485_RS08175	COG0656	L-ascorbic acid biosynthetic process
AL485_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS08190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL485_RS08195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL485_RS08225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL485_RS08230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL485_RS08240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL485_RS08290	COG0542	response to heat
AL485_RS08300	COG0564	pseudouridine synthase activity
AL485_RS08305	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL485_RS08310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL485_RS08315	COG1605	Chorismate mutase
AL485_RS08315	COG0077	Prephenate dehydratase
AL485_RS08320	COG0287	Prephenate dehydrogenase
AL485_RS08320	COG1605	Chorismate mutase
AL485_RS08325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL485_RS08335	COG3137	Salt-induced outer membrane protein
AL485_RS08345	COG0335	large ribosomal subunit rRNA binding
AL485_RS08355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL485_RS08360	COG0228	four-way junction DNA binding
AL485_RS08365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL485_RS08370	COG4137	Cytochrome C assembly protein
AL485_RS08375	COG4536	flavin adenine dinucleotide binding
AL485_RS08380	COG1854	S-ribosylhomocysteine lyase activity
AL485_RS08385	COG2918	glutathione biosynthetic process
AL485_RS08390	COG1238	metal cluster binding
AL485_RS08395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL485_RS08430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AL485_RS08435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL485_RS08440	COG2137	regulation of response to DNA damage stimulus
AL485_RS08445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL485_RS08465	COG1917	Cupin 2, conserved barrel domain protein
AL485_RS08465	COG2169	Transcriptional regulator
AL485_RS08470	COG2723	6-phospho-beta-galactosidase activity
AL485_RS08475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL485_RS08480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL485_RS08485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL485_RS08490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL485_RS08495	COG4942	peptidase
AL485_RS08495	COG1388	LysM domain
AL485_RS08505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL485_RS08510	COG0585	pseudouridine synthase activity
AL485_RS08515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL485_RS08520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL485_RS08525	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL485_RS08535	COG0765	amino acid transport
AL485_RS08550	COG0529	Catalyzes the synthesis of activated sulfate
AL485_RS08555	COG2895	sulfate adenylyltransferase (ATP) activity
AL485_RS08560	COG0175	sulfate reduction
AL485_RS08565	COG1648	precorrin-2 dehydrogenase activity
AL485_RS08565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL485_RS08570	COG2234	aminopeptidase activity
AL485_RS08575	COG0175	sulfate reduction
AL485_RS08580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL485_RS08585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL485_RS08590	COG0720	synthase
AL485_RS08595	COG0602	queuosine metabolic process
AL485_RS08600	COG2271	Major facilitator Superfamily
AL485_RS08605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL485_RS08610	COG2986	histidine ammonia-lyase
AL485_RS08625	COG4176	ABC-type proline glycine betaine transport system permease component
AL485_RS08630	COG4175	Glycine betaine
AL485_RS08635	COG2986	histidine ammonia-lyase
AL485_RS08655	COG0148	phosphopyruvate hydratase activity
AL485_RS08660	COG0504	CTP synthase activity
AL485_RS08665	COG3956	TIGRFAM MazG family protein
AL485_RS08670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL485_RS08675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL485_RS08685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL485_RS08690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL485_RS08695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL485_RS08705	COG2860	membrane
AL485_RS08715	COG0316	Belongs to the HesB IscA family
AL485_RS08725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL485_RS08730	COG3725	Membrane protein required for beta-lactamase induction
AL485_RS08735	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL485_RS08810	COG4969	Belongs to the N-Me-Phe pilin family
AL485_RS08820	COG1459	type II secretion system
AL485_RS08825	COG0516	GMP reductase activity
AL485_RS08835	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL485_RS08840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL485_RS08845	COG0494	nUDIX hydrolase
AL485_RS08850	COG0653	protein targeting
AL485_RS08870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL485_RS08875	COG0849	cell division
AL485_RS08880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL485_RS08890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL485_RS08895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL485_RS08900	COG0772	Belongs to the SEDS family
AL485_RS08910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL485_RS08915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL485_RS08920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL485_RS08925	COG0768	penicillin binding
AL485_RS08930	COG3116	cell division
AL485_RS08935	COG0275	rRNA processing
AL485_RS08940	COG2001	Belongs to the MraZ family
AL485_RS08960	COG0028	Belongs to the TPP enzyme family
AL485_RS08965	COG1022	Amp-dependent synthetase and ligase
AL485_RS08975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL485_RS08980	COG0473	3-isopropylmalate dehydrogenase activity
AL485_RS08985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL485_RS08990	COG0066	3-isopropylmalate dehydratase activity
AL485_RS09000	COG2814	Major facilitator Superfamily
AL485_RS09010	COG4143	(ABC) transporter
AL485_RS09015	COG1178	ABC-type Fe3 transport system permease component
AL485_RS09025	COG0028	Belongs to the TPP enzyme family
AL485_RS09030	COG0440	acetolactate synthase activity
AL485_RS09035	COG0586	Pfam SNARE associated Golgi protein
AL485_RS09040	COG0417	DNA replication proofreading
AL485_RS09045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL485_RS09050	COG0564	pseudouridine synthase activity
AL485_RS09060	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL485_RS09070	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL485_RS09075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL485_RS09080	COG2967	ApaG domain
AL485_RS09095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL485_RS09105	COG2966	Psort location CytoplasmicMembrane, score
AL485_RS09120	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL485_RS09125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL485_RS09130	COG0505	Belongs to the CarA family
AL485_RS09135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL485_RS09140	COG2186	Transcriptional regulator
AL485_RS09145	COG3734	2-keto-3-deoxy-galactonokinase
AL485_RS09150	COG0800	Aldolase
AL485_RS09160	COG2271	Major facilitator Superfamily
AL485_RS09165	COG0129	dihydroxy-acid dehydratase activity
AL485_RS09170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL485_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS09200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL485_RS09205	COG1047	Peptidyl-prolyl cis-trans
AL485_RS09210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL485_RS09215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL485_RS09220	COG0196	riboflavin kinase activity
AL485_RS09225	COG0268	Binds directly to 16S ribosomal RNA
AL485_RS09230	COG0583	DNA-binding transcription factor activity
AL485_RS09235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL485_RS09240	COG0484	heat shock protein binding
AL485_RS09245	COG0443	Heat shock 70 kDa protein
AL485_RS09250	COG1584	GPR1 FUN34 yaaH family protein
AL485_RS09260	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL485_RS09265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL485_RS09270	COG1115	amino acid carrier protein
AL485_RS09275	COG3022	response to hydroperoxide
AL485_RS09285	COG0083	homoserine kinase activity
AL485_RS09300	COG0745	RESPONSE REGULATOR receiver
AL485_RS09305	COG3045	CreA protein
AL485_RS09310	COG3708	Transcriptional regulator
AL485_RS09310	COG2207	Transcriptional regulator
AL485_RS09315	COG0406	alpha-ribazole phosphatase activity
AL485_RS09320	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL485_RS09325	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL485_RS09330	COG0741	lytic transglycosylase activity
AL485_RS09340	COG2199	diguanylate cyclase activity
AL485_RS09345	COG2885	chlorophyll binding
AL485_RS09350	COG0488	(ABC) transporter
AL485_RS09360	COG0604	alcohol dehydrogenase
AL485_RS09375	COG0560	Phosphoserine phosphatase
AL485_RS09380	COG3726	membrane protein affecting hemolysin expression
AL485_RS09390	COG0813	purine-nucleoside phosphorylase activity
AL485_RS09395	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL485_RS09400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL485_RS09405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL485_RS09410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL485_RS09415	COG0084	hydrolase, TatD family'
AL485_RS09420	COG4667	esterase of the alpha-beta hydrolase superfamily
AL485_RS09425	COG3237	CsbD-like
AL485_RS09430	COG2823	Periplasmic or secreted lipoprotein
AL485_RS09435	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL485_RS09445	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AL485_RS09450	COG2813	Specifically methylates the guanine in position
AL485_RS09455	COG0667	Aldo Keto reductase
AL485_RS09490	COG0738	Major facilitator superfamily
AL485_RS09495	COG3254	rhamnose metabolic process
AL485_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS09505	COG3618	amidohydrolase
AL485_RS09510	COG4948	Mandelate Racemase Muconate Lactonizing
AL485_RS09515	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL485_RS09520	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS09530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL485_RS09535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL485_RS09540	COG2368	4-hydroxyphenylacetate
AL485_RS09560	COG3971	2-oxopent-4-enoate hydratase activity
AL485_RS09575	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS09590	COG1846	Transcriptional regulator
AL485_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS09615	COG1113	amino acid transport
AL485_RS09635	COG2267	carboxylic ester hydrolase activity
AL485_RS09645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL485_RS09655	COG1454	alcohol dehydrogenase
AL485_RS09695	COG0811	peptide transport
AL485_RS09720	COG1376	ErfK ybiS ycfS ynhG family protein
AL485_RS09725	COG3708	Transcriptional regulator
AL485_RS09725	COG2207	Transcriptional regulator
AL485_RS09735	COG2207	Transcriptional regulator
AL485_RS09745	COG3391	amine dehydrogenase activity
AL485_RS09755	COG0174	glutamine synthetase
AL485_RS09770	COG1966	Carbon starvation protein
AL485_RS09775	COG2879	small protein
AL485_RS09780	COG0523	cobalamin synthesis protein
AL485_RS09795	COG1609	Transcriptional regulator
AL485_RS09800	COG1263	PTS System
AL485_RS09800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS09805	COG2723	6-phospho-beta-galactosidase activity
AL485_RS09825	COG1401	restriction endodeoxyribonuclease activity
AL485_RS09840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL485_RS09850	COG1396	sequence-specific DNA binding
AL485_RS09860	COG1280	lysine exporter protein (LysE YggA)
AL485_RS09880	COG0795	lipopolysaccharide-transporting ATPase activity
AL485_RS09885	COG0795	lipopolysaccharide-transporting ATPase activity
AL485_RS09890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL485_RS09895	COG2927	DNA polymerase III (CHI subunit)
AL485_RS09905	COG0456	acetyltransferase
AL485_RS09915	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AL485_RS09925	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AL485_RS09930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL485_RS09945	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AL485_RS09960	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL485_RS09970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL485_RS09975	COG0540	Belongs to the ATCase OTCase family
AL485_RS09980	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL485_RS09995	COG2308	Evidence 4 Homologs of previously reported genes of
AL485_RS10035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS10035	COG1263	PTS System
AL485_RS10040	COG0366	Alpha amylase catalytic
AL485_RS10045	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL485_RS10050	COG0583	DNA-binding transcription factor activity
AL485_RS10075	COG0701	Predicted permease
AL485_RS10080	COG2188	Transcriptional regulator
AL485_RS10085	COG3624	Phosphonate C-P lyase system protein PhnG
AL485_RS10090	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AL485_RS10095	COG3626	phosphonate metabolism
AL485_RS10100	COG3627	carbon phosphorus lyase activity
AL485_RS10105	COG4107	phosphonate C-P lyase system protein PhnK
AL485_RS10110	COG4778	phosphonate C-P lyase system protein PhnL
AL485_RS10120	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AL485_RS10130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL485_RS10135	COG0702	epimerase
AL485_RS10140	COG3787	Belongs to the UPF0306 family
AL485_RS10145	COG1982	Orn Lys Arg decarboxylase major
AL485_RS10160	COG3153	acetyltransferase
AL485_RS10165	COG3154	lipid carrier protein
AL485_RS10175	COG0826	peptidase U32
AL485_RS10180	COG2850	peptidyl-arginine hydroxylation
AL485_RS10200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS10205	COG0425	Belongs to the sulfur carrier protein TusA family
AL485_RS10210	COG2391	methyltransferase activity
AL485_RS10215	COG0513	Belongs to the DEAD box helicase family
AL485_RS10225	COG1185	polyribonucleotide nucleotidyltransferase activity
AL485_RS10230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL485_RS10235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL485_RS10240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL485_RS10245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL485_RS10250	COG0195	Participates in both transcription termination and antitermination
AL485_RS10255	COG0779	Required for maturation of 30S ribosomal subunits
AL485_RS10270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL485_RS10275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL485_RS10280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL485_RS10285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL485_RS10290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL485_RS10295	COG1534	Rna-binding protein
AL485_RS10305	COG2027	D-alanyl-D-alanine carboxypeptidase
AL485_RS10310	COG0745	RESPONSE REGULATOR receiver
AL485_RS10315	COG0642	Histidine kinase
AL485_RS10320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL485_RS10325	COG0697	spore germination
AL485_RS10330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL485_RS10335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL485_RS10340	COG0142	geranyltranstransferase activity
AL485_RS10350	COG3423	Transcriptional regulator
AL485_RS10355	COG0039	L-malate dehydrogenase activity
AL485_RS10360	COG1438	arginine binding
AL485_RS10375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL485_RS10380	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL485_RS10385	COG0840	transmembrane signaling receptor activity
AL485_RS10390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL485_RS10395	COG2105	PFAM AIG2 family protein
AL485_RS10400	COG2911	Protein conserved in bacteria
AL485_RS10405	COG0729	surface antigen
AL485_RS10410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL485_RS10415	COG1253	flavin adenine dinucleotide binding
AL485_RS10425	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL485_RS10430	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL485_RS10435	COG0737	Belongs to the 5'-nucleotidase family
AL485_RS10440	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AL485_RS10445	COG0545	Peptidyl-prolyl cis-trans isomerase
AL485_RS10450	COG3061	Opacity-associated protein A
AL485_RS10460	COG0359	binds to the 23S rRNA
AL485_RS10465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL485_RS10470	COG0360	Binds together with S18 to 16S ribosomal RNA
AL485_RS10480	COG1073	alpha beta
AL485_RS10485	COG3650	response to hydrogen peroxide
AL485_RS10495	COG3766	membrane
AL485_RS10500	COG1960	acyl-CoA dehydrogenase activity
AL485_RS10505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL485_RS10510	COG0557	exoribonuclease II activity
AL485_RS10515	COG1959	2 iron, 2 sulfur cluster binding
AL485_RS10520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL485_RS10525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL485_RS10530	COG0330	HflC and HflK could
AL485_RS10535	COG0330	HflC and HflK could
AL485_RS10545	COG1923	regulation of RNA biosynthetic process
AL485_RS10550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL485_RS10555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL485_RS10560	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL485_RS10565	COG0802	atpase or kinase
AL485_RS10570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL485_RS10570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL485_RS10575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL485_RS10595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL485_RS10600	COG1162	GTPase activity
AL485_RS10605	COG0688	phosphatidylethanolamine metabolic process
AL485_RS10610	COG3264	Mechanosensitive ion channel
AL485_RS10610	COG1511	domain protein
AL485_RS10615	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL485_RS10620	COG1053	succinate dehydrogenase
AL485_RS10625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL485_RS10630	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL485_RS10635	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL485_RS10650	COG5510	response to toxic substance
AL485_RS10655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL485_RS10675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL485_RS10695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL485_RS10705	COG4232	protein-disulfide reductase activity
AL485_RS10710	COG1309	transcriptional regulator
AL485_RS10720	COG2205	protein histidine kinase activity
AL485_RS10720	COG0784	Response regulator, receiver
AL485_RS10720	COG2198	Histidine kinase
AL485_RS10725	COG1879	ABC-type sugar transport system periplasmic component
AL485_RS10735	COG3005	denitrification pathway
AL485_RS10740	COG0243	molybdopterin cofactor binding
AL485_RS10775	COG3647	Membrane
AL485_RS10780	COG4942	peptidase
AL485_RS10785	COG1301	dicarboxylic acid transport
AL485_RS10790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL485_RS10795	COG3162	membrane
AL485_RS10800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL485_RS10830	COG0138	bifunctional purine biosynthesis protein purh
AL485_RS10835	COG0151	Belongs to the GarS family
AL485_RS10855	COG1515	deoxyribonuclease V activity
AL485_RS10860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL485_RS10865	COG2816	NAD+ diphosphatase activity
AL485_RS10870	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL485_RS10880	COG0352	thiamine-phosphate diphosphorylase activity
AL485_RS10885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL485_RS10890	COG2104	thiamine diphosphate biosynthetic process
AL485_RS10895	COG2022	thiamine diphosphate biosynthetic process
AL485_RS10915	COG2205	protein histidine kinase activity
AL485_RS10930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL485_RS10935	COG0085	RNA polymerase activity
AL485_RS10940	COG0222	ribosome binding
AL485_RS10945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL485_RS10950	COG0081	regulation of translation
AL485_RS10960	COG0250	Participates in transcription elongation, termination and antitermination
AL485_RS10970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL485_RS11005	COG1072	(Pantothenic acid kinase))
AL485_RS11010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL485_RS11010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL485_RS11015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL485_RS11045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL485_RS11050	COG1739	Uncharacterized protein family UPF0029
AL485_RS11055	COG0006	proline dipeptidase activity
AL485_RS11065	COG1024	Enoyl-CoA hydratase
AL485_RS11065	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL485_RS11070	COG0183	Belongs to the thiolase family
AL485_RS11100	COG0084	hydrolase, TatD family'
AL485_RS11105	COG0805	protein transport
AL485_RS11115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL485_RS11120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL485_RS11125	COG3165	ubiquinone biosynthetic process from chorismate
AL485_RS11130	COG2226	methyltransferase
AL485_RS11135	COG1322	Protein conserved in bacteria
AL485_RS11140	COG0586	Pfam SNARE associated Golgi protein
AL485_RS11155	COG0412	Dienelactone hydrolase
AL485_RS11160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL485_RS11185	COG0584	glycerophosphoryl diester phosphodiesterase
AL485_RS11190	COG3842	ATPase activity
AL485_RS11200	COG1175	transmembrane transport
AL485_RS11205	COG1653	transport
AL485_RS11210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL485_RS11215	COG0410	ABC transporter
AL485_RS11230	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL485_RS11240	COG0456	acetyltransferase
AL485_RS11260	COG2177	Part of the ABC transporter FtsEX involved in
AL485_RS11265	COG2884	Cell division ATP-binding protein ftsE
AL485_RS11270	COG0552	protein localization to endoplasmic reticulum
AL485_RS11270	COG0552	protein localization to endoplasmic reticulum
AL485_RS11275	COG0742	ribosomal rna small subunit methyltransferase
AL485_RS11280	COG3776	membrane
AL485_RS11290	COG2197	response regulator
AL485_RS11310	COG0582	viral genome integration into host DNA
AL485_RS11325	COG0582	viral genome integration into host DNA
AL485_RS11330	COG3714	YhhN family
AL485_RS11370	COG0425	Belongs to the sulfur carrier protein TusA family
AL485_RS11375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL485_RS11380	COG0456	acetyltransferase
AL485_RS11390	COG0247	lactate metabolic process
AL485_RS11400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL485_RS11405	COG2271	Major facilitator Superfamily
AL485_RS11410	COG0584	glycerophosphoryl diester phosphodiesterase
AL485_RS11415	COG0561	phosphatase activity
AL485_RS11420	COG2267	carboxylic ester hydrolase activity
AL485_RS11425	COG1280	lysine exporter protein (LysE YggA)
AL485_RS11430	COG1280	lysine exporter protein (LysE YggA)
AL485_RS11435	COG0514	ATP-dependent DNA helicase (RecQ)
AL485_RS11440	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AL485_RS11445	COG2050	protein possibly involved in aromatic compounds catabolism
AL485_RS11455	COG3180	Ammonia monooxygenase
AL485_RS11470	COG0210	DNA helicase
AL485_RS11475	COG1011	Hydrolase
AL485_RS11485	COG3159	Protein conserved in bacteria
AL485_RS11490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL485_RS11500	COG1965	Belongs to the frataxin family
AL485_RS11505	COG3072	Adenylate cyclase
AL485_RS11510	COG0181	hydroxymethylbilane synthase activity
AL485_RS11520	COG2959	enzyme of heme biosynthesis
AL485_RS11525	COG3071	HemY protein
AL485_RS11560	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL485_RS11570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL485_RS11575	COG2244	polysaccharide biosynthetic process
AL485_RS11580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL485_RS11585	COG0456	acetyltransferase
AL485_RS11590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AL485_RS11595	COG1088	dTDP-glucose 4,6-dehydratase activity
AL485_RS11600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL485_RS11605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL485_RS11615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL485_RS11620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL485_RS11625	COG3118	belongs to the thioredoxin family
AL485_RS11630	COG0513	Belongs to the DEAD box helicase family
AL485_RS11635	COG0248	Ppx GppA phosphatase
AL485_RS11645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL485_RS11650	COG0612	Peptidase, M16
AL485_RS11655	COG1301	dicarboxylic acid transport
AL485_RS11660	COG2200	EAL domain
AL485_RS11660	COG2199	diguanylate cyclase activity
AL485_RS11665	COG0457	Tetratricopeptide repeat
AL485_RS11665	COG3118	belongs to the thioredoxin family
AL485_RS11670	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AL485_RS11675	COG1215	transferase activity, transferring glycosyl groups
AL485_RS11680	COG1215	transferase activity, transferring glycosyl groups
AL485_RS11705	COG2194	sulfuric ester hydrolase activity
AL485_RS11710	COG4608	Belongs to the ABC transporter superfamily
AL485_RS11715	COG0444	Belongs to the ABC transporter superfamily
AL485_RS11720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL485_RS11725	COG0601	transmembrane transport
AL485_RS11730	COG0747	negative chemotaxis
AL485_RS11760	COG2271	Major facilitator Superfamily
AL485_RS11770	COG2197	response regulator
AL485_RS11775	COG2194	sulfuric ester hydrolase activity
AL485_RS11780	COG1764	response to oxidative stress
AL485_RS11785	COG1846	Transcriptional regulator
AL485_RS11835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL485_RS11840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL485_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS11850	COG1609	Transcriptional regulator
AL485_RS11890	COG2807	transmembrane transport
AL485_RS11895	COG0583	DNA-binding transcription factor activity
AL485_RS11910	COG2207	Transcriptional regulator
AL485_RS11910	COG1609	Transcriptional regulator
AL485_RS11915	COG4214	carbohydrate transport
AL485_RS11925	COG4213	ABC transporter substrate-binding protein
AL485_RS11930	COG2115	Belongs to the xylose isomerase family
AL485_RS11935	COG1070	Carbohydrate kinase
AL485_RS11940	COG0402	S-adenosylhomocysteine deaminase activity
AL485_RS11945	COG1335	isochorismatase
AL485_RS11955	COG3274	enterobacterial common antigen metabolic process
AL485_RS11965	COG3276	selenocysteine insertion sequence binding
AL485_RS11970	COG1921	L-seryl-tRNASec selenium transferase activity
AL485_RS11975	COG0625	glutathione transferase activity
AL485_RS11985	COG3058	Necessary for formate dehydrogenase activity
AL485_RS11990	COG2864	formate dehydrogenase
AL485_RS11995	COG0437	4 iron, 4 sulfur cluster binding
AL485_RS12000	COG3383	formate dehydrogenase (NAD+) activity
AL485_RS12000	COG0243	molybdopterin cofactor binding
AL485_RS12005	COG0243	molybdopterin cofactor binding
AL485_RS12005	COG3383	formate dehydrogenase (NAD+) activity
AL485_RS12015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL485_RS12040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL485_RS12050	COG3722	fumarate hydratase activity
AL485_RS12055	COG0246	Mannitol dehydrogenase
AL485_RS12060	COG2213	PTS system mannitol-specific
AL485_RS12060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL485_RS12075	COG0751	glycine-tRNA ligase activity
AL485_RS12080	COG0752	glycyl-tRNA synthetase alpha subunit
AL485_RS12085	COG2271	Major facilitator Superfamily
AL485_RS12095	COG2818	Glycosylase
AL485_RS12100	COG0456	acetyltransferase
AL485_RS12105	COG2885	chlorophyll binding
AL485_RS12110	COG1609	Transcriptional regulator
AL485_RS12120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL485_RS12125	COG2814	Major facilitator Superfamily
AL485_RS12130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL485_RS12135	COG0366	Alpha amylase catalytic
AL485_RS12140	COG3977	Valine--pyruvate aminotransferase
AL485_RS12145	COG2985	domain, Protein
AL485_RS12150	COG0071	Belongs to the small heat shock protein (HSP20) family
AL485_RS12155	COG0071	Belongs to the small heat shock protein (HSP20) family
AL485_RS12165	COG5645	(Lipo)protein
AL485_RS12170	COG0823	Involved in the tonB-independent uptake of proteins
AL485_RS12175	COG2271	Major facilitator Superfamily
AL485_RS12185	COG4948	Mandelate Racemase Muconate Lactonizing
AL485_RS12190	COG0800	Aldolase
AL485_RS12195	COG3734	2-keto-3-deoxy-galactonokinase
AL485_RS12200	COG2186	Transcriptional regulator
AL485_RS12205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL485_RS12210	COG2423	ornithine cyclodeaminase activity
AL485_RS12215	COG0561	phosphatase activity
AL485_RS12220	COG0187	DNA topoisomerase II activity
AL485_RS12225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL485_RS12230	COG0592	DNA-directed DNA polymerase activity
AL485_RS12235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL485_RS12240	COG0594	ribonuclease P activity
AL485_RS12245	COG0706	membrane insertase activity
AL485_RS12250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL485_RS12265	COG2091	lysine biosynthetic process via aminoadipic acid
AL485_RS12270	COG0431	NADPH-dependent FMN reductase
AL485_RS12280	COG2252	PERMEase
AL485_RS12285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL485_RS12295	COG0765	amino acid transport
AL485_RS12300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS12305	COG0704	Plays a role in the regulation of phosphate uptake
AL485_RS12315	COG0581	inorganic phosphate transmembrane transporter activity
AL485_RS12320	COG0573	inorganic phosphate transmembrane transporter activity
AL485_RS12325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL485_RS12335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL485_RS12340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL485_RS12345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL485_RS12350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL485_RS12355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL485_RS12360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL485_RS12365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL485_RS12380	COG3312	ion transport
AL485_RS12385	COG0357	Ribosomal RNA small subunit methyltransferase G
AL485_RS12390	COG0445	tRNA wobble uridine modification
AL485_RS12395	COG0716	FMN binding
AL485_RS12400	COG1522	sequence-specific DNA binding
AL485_RS12405	COG2502	aspartate--ammonia ligase
AL485_RS12410	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL485_RS12415	COG0714	Associated with various cellular activities
AL485_RS12420	COG3158	transport of potassium into the cell
AL485_RS12425	COG1869	D-ribose catabolic process
AL485_RS12430	COG1129	ABC transporter
AL485_RS12435	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS12445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL485_RS12450	COG1609	Transcriptional regulator
AL485_RS12455	COG0477	Major facilitator Superfamily
AL485_RS12460	COG2186	Transcriptional regulator
AL485_RS12485	COG1763	Mo-molybdopterin cofactor biosynthetic process
AL485_RS12490	COG0746	molybdenum cofactor guanylyltransferase activity
AL485_RS12495	COG3084	Protein conserved in bacteria
AL485_RS12500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL485_RS12505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL485_RS12510	COG0204	Acyl-transferase
AL485_RS12515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL485_RS12515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL485_RS12520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL485_RS12525	COG3078	GTPase activator activity
AL485_RS12530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL485_RS12540	COG3852	Histidine kinase
AL485_RS12545	COG0174	glutamine synthetase
AL485_RS12550	COG1217	gtp-binding protein TYPA
AL485_RS12555	COG1011	Hydrolase
AL485_RS12560	COG1295	ribonuclease BN
AL485_RS12565	COG1490	D-aminoacyl-tRNA deacylase activity
AL485_RS12570	COG0456	acetyltransferase
AL485_RS12580	COG2982	Protein involved in outer membrane biogenesis
AL485_RS12585	COG2233	PERMEase
AL485_RS12590	COG0786	glutamate:sodium symporter activity
AL485_RS12595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL485_RS12600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL485_RS12605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL485_RS12610	COG1758	RNA polymerase activity
AL485_RS12615	COG0194	GDP metabolic process
AL485_RS12625	COG2860	membrane
AL485_RS12635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL485_RS12640	COG4221	oxidoreductase activity
AL485_RS12645	COG1561	YicC-like family, N-terminal region
AL485_RS12650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL485_RS12655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL485_RS12660	COG1309	transcriptional regulator
AL485_RS12665	COG0756	dUTP diphosphatase activity
AL485_RS12670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL485_RS12680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL485_RS12690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL485_RS12695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL485_RS12705	COG1519	Transferase
AL485_RS12715	COG0438	transferase activity, transferring glycosyl groups
AL485_RS12720	COG0438	transferase activity, transferring glycosyl groups
AL485_RS12725	COG0859	PFAM glycosyl transferase family 9
AL485_RS12735	COG0859	PFAM glycosyl transferase family 9
AL485_RS12750	COG0859	PFAM glycosyl transferase family 9
AL485_RS12755	COG0859	PFAM glycosyl transferase family 9
AL485_RS12760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL485_RS12765	COG0156	8-amino-7-oxononanoate synthase activity
AL485_RS12770	COG1063	alcohol dehydrogenase
AL485_RS12775	COG2861	carbohydrate metabolic process
AL485_RS12780	COG4942	peptidase
AL485_RS12785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL485_RS12790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL485_RS12795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL485_RS12800	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL485_RS12805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL485_RS12810	COG1045	serine acetyltransferase
AL485_RS12825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL485_RS12830	COG2205	protein histidine kinase activity
AL485_RS12835	COG0745	RESPONSE REGULATOR receiver
AL485_RS12840	COG3678	ATP-independent chaperone mediated protein folding
AL485_RS12845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL485_RS12850	COG0205	6-phosphofructokinase activity
AL485_RS12855	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AL485_RS12860	COG0149	triose-phosphate isomerase activity
AL485_RS12870	COG3152	Membrane
AL485_RS12885	COG2814	Major facilitator Superfamily
AL485_RS12890	COG1494	fructose-1,6-bisphosphatase
AL485_RS12900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL485_RS12910	COG3074	FtsZ-dependent cytokinesis
AL485_RS12915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL485_RS12920	COG1575	Belongs to the MenA family. Type 1 subfamily
AL485_RS12925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL485_RS12930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL485_RS12935	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL485_RS12940	COG1609	Transcriptional regulator
AL485_RS12945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL485_RS12950	COG0254	rRNA binding
AL485_RS12955	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL485_RS12960	COG0626	cystathionine gamma-synthase activity
AL485_RS12965	COG0460	homoserine dehydrogenase
AL485_RS12965	COG0527	aspartate kinase activity
AL485_RS12970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL485_RS12975	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL485_RS12990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL485_RS12995	COG0137	argininosuccinate synthase activity
AL485_RS13000	COG0165	Argininosuccinate lyase
AL485_RS13010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL485_RS13015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL485_RS13015	COG0678	peroxiredoxin activity
AL485_RS13025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL485_RS13040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL485_RS13050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL485_RS13090	COG1879	ABC-type sugar transport system periplasmic component
AL485_RS13095	COG1129	ABC transporter
AL485_RS13100	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS13105	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS13110	COG0583	DNA-binding transcription factor activity
AL485_RS13115	COG3085	chromosome segregation
AL485_RS13120	COG0606	chelatase, subunit chli
AL485_RS13125	COG2814	Major facilitator Superfamily
AL485_RS13135	COG3978	acetolactate synthase activity
AL485_RS13140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL485_RS13145	COG0129	dihydroxy-acid dehydratase activity
AL485_RS13150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL485_RS13160	COG0583	DNA-binding transcription factor activity
AL485_RS13165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL485_RS13170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL485_RS13175	COG1942	4-Oxalocrotonate Tautomerase
AL485_RS13180	COG2200	EAL domain
AL485_RS13185	COG2982	Protein involved in outer membrane biogenesis
AL485_RS13190	COG2134	cdp-diacylglycerol pyrophosphatase
AL485_RS13195	COG0477	Major facilitator Superfamily
AL485_RS13200	COG1295	ribonuclease BN
AL485_RS13205	COG1024	Enoyl-CoA hydratase
AL485_RS13210	COG5001	Diguanylate cyclase
AL485_RS13215	COG3678	ATP-independent chaperone mediated protein folding
AL485_RS13235	COG2205	protein histidine kinase activity
AL485_RS13235	COG0784	Response regulator, receiver
AL485_RS13245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL485_RS13250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL485_RS13265	COG0154	amidase activity
AL485_RS13275	COG0339	signal peptide processing
AL485_RS13280	COG0742	ribosomal rna small subunit methyltransferase
AL485_RS13285	COG0737	Belongs to the 5'-nucleotidase family
AL485_RS13300	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS13305	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS13310	COG1129	ABC transporter
AL485_RS13325	COG0589	response to stress
AL485_RS13335	COG0306	phosphate transporter
AL485_RS13340	COG2081	HI0933 family
AL485_RS13385	COG2197	response regulator
AL485_RS13415	COG3188	usher protein
AL485_RS13445	COG4619	ABC transporter
AL485_RS13450	COG0390	transport system, permease component
AL485_RS13460	COG0477	Major facilitator Superfamily
AL485_RS13460	COG2814	Major facilitator Superfamily
AL485_RS13470	COG3718	enzyme involved in inositol metabolism
AL485_RS13480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL485_RS13485	COG3962	Belongs to the TPP enzyme family
AL485_RS13490	COG0673	inositol 2-dehydrogenase activity
AL485_RS13495	COG1082	Xylose isomerase domain protein TIM barrel
AL485_RS13500	COG1082	Xylose isomerase domain protein TIM barrel
AL485_RS13505	COG3191	aminopeptidase activity
AL485_RS13510	COG1247	-acetyltransferase
AL485_RS13515	COG1741	Belongs to the pirin family
AL485_RS13520	COG1609	Transcriptional regulator
AL485_RS13525	COG2610	gluconate transmembrane transporter activity
AL485_RS13530	COG3265	gluconokinase activity
AL485_RS13535	COG2095	MarC family integral membrane protein
AL485_RS13540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL485_RS13545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL485_RS13550	COG1523	belongs to the glycosyl hydrolase 13 family
AL485_RS13555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL485_RS13565	COG0058	SHG alpha-glucan phosphorylase activity
AL485_RS13570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL485_RS13575	COG1349	DNA-binding transcription factor activity
AL485_RS13580	COG0705	Rhomboid family
AL485_RS13585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL485_RS13635	COG2909	trisaccharide binding
AL485_RS13640	COG0058	SHG alpha-glucan phosphorylase activity
AL485_RS13645	COG1640	4-alpha-glucanotransferase
AL485_RS13650	COG0316	Belongs to the HesB IscA family
AL485_RS13650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL485_RS13655	COG1040	competence protein
AL485_RS13660	COG2267	carboxylic ester hydrolase activity
AL485_RS13680	COG1918	ferrous iron import across plasma membrane
AL485_RS13685	COG2183	response to ionizing radiation
AL485_RS13690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL485_RS13720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL485_RS13725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL485_RS13730	COG1011	Hydrolase
AL485_RS13740	COG0494	nUDIX hydrolase
AL485_RS13745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL485_RS13770	COG4796	Type ii and iii secretion system protein
AL485_RS13780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL485_RS13785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL485_RS13805	COG0546	phosphoglycolate phosphatase activity
AL485_RS13810	COG0180	Tryptophanyl-tRNA synthetase
AL485_RS13815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL485_RS13815	COG1648	precorrin-2 dehydrogenase activity
AL485_RS13830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL485_RS13835	COG0402	S-adenosylhomocysteine deaminase activity
AL485_RS13840	COG0738	Major facilitator superfamily
AL485_RS13845	COG1609	Transcriptional regulator
AL485_RS13850	COG1486	melibiose metabolic process
AL485_RS13855	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL485_RS13860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL485_RS13865	COG3275	phosphorelay sensor kinase activity
AL485_RS13885	COG0433	COG0433 Predicted ATPase
AL485_RS13900	COG1289	transmembrane transporter activity
AL485_RS13905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL485_RS13910	COG1765	OsmC-like protein
AL485_RS13915	COG3954	Phosphoribulokinase
AL485_RS13920	COG3089	Belongs to the UPF0270 family
AL485_RS13925	COG0429	hydrolase of the alpha beta-hydrolase fold
AL485_RS13940	COG4521	taurine ABC transporter
AL485_RS13950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL485_RS13955	COG2175	clavaminate synthase activity
AL485_RS13960	COG0488	(ABC) transporter
AL485_RS13965	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL485_RS13975	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AL485_RS13980	COG1047	Peptidyl-prolyl cis-trans
AL485_RS13985	COG2900	Belongs to the SlyX family
AL485_RS13990	COG0545	Peptidyl-prolyl cis-trans isomerase
AL485_RS13995	COG2964	Protein conserved in bacteria
AL485_RS14000	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL485_RS14005	COG2923	Belongs to the DsrF TusC family
AL485_RS14010	COG2168	tRNA wobble position uridine thiolation
AL485_RS14015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL485_RS14020	COG0049	tRNA binding
AL485_RS14025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL485_RS14030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL485_RS14045	COG0051	transcription antitermination factor activity, RNA binding
AL485_RS14050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL485_RS14055	COG0088	Forms part of the polypeptide exit tunnel
AL485_RS14060	COG0089	rRNA binding
AL485_RS14065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL485_RS14070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL485_RS14080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL485_RS14085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL485_RS14090	COG0255	Belongs to the universal ribosomal protein uL29 family
AL485_RS14095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL485_RS14100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL485_RS14105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL485_RS14110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL485_RS14115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL485_RS14125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL485_RS14130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL485_RS14135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL485_RS14145	COG0200	Binds to the 23S rRNA
AL485_RS14150	COG0201	protein transport
AL485_RS14155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL485_RS14160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL485_RS14165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL485_RS14170	COG0202	RNA polymerase activity
AL485_RS14175	COG0203	ribosomal protein L17
AL485_RS14185	COG0789	Transcriptional regulator
AL485_RS14190	COG3036	rescue of stalled ribosome
AL485_RS14195	COG1970	mechanosensitive ion channel activity
AL485_RS14200	COG0569	domain protein
AL485_RS14205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL485_RS14205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL485_RS14210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL485_RS14215	COG0242	peptide deformylase activity
AL485_RS14220	COG0758	DNA mediated transformation
AL485_RS14225	COG2922	Belongs to the Smg family
AL485_RS14230	COG0551	DNA topoisomerase type I activity
AL485_RS14235	COG0009	L-threonylcarbamoyladenylate synthase
AL485_RS14245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL485_RS14280	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL485_RS14285	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL485_RS14295	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AL485_RS14300	COG0800	Aldolase
AL485_RS14305	COG0129	dihydroxy-acid dehydratase activity
AL485_RS14310	COG2610	gluconate transmembrane transporter activity
AL485_RS14315	COG3265	gluconokinase activity
AL485_RS14320	COG1414	Transcriptional regulator
AL485_RS14330	COG2188	Transcriptional regulator
AL485_RS14345	COG4149	molybdate abc transporter
AL485_RS14355	COG3842	ATPase activity
AL485_RS14360	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL485_RS14380	COG0527	aspartate kinase activity
AL485_RS14390	COG0166	Belongs to the GPI family
AL485_RS14400	COG3223	Belongs to the PsiE family
AL485_RS14405	COG3833	ABC-type maltose transport systems, permease component
AL485_RS14410	COG1175	transmembrane transport
AL485_RS14415	COG2182	Extracellular solute-binding protein
AL485_RS14420	COG0366	Alpha amylase catalytic
AL485_RS14430	COG4580	involved in the transport of maltose and maltodextrins
AL485_RS14445	COG1609	Transcriptional regulator
AL485_RS14450	COG0477	Major facilitator Superfamily
AL485_RS14455	COG3161	chorismate lyase activity
AL485_RS14460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL485_RS14465	COG2937	Belongs to the GPAT DAPAT family
AL485_RS14470	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL485_RS14475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL485_RS14480	COG0534	Mate efflux family protein
AL485_RS14485	COG3237	CsbD-like
AL485_RS14490	COG0735	belongs to the Fur family
AL485_RS14500	COG1595	DNA-templated transcription, initiation
AL485_RS14510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL485_RS14525	COG0604	alcohol dehydrogenase
AL485_RS14545	COG1522	sequence-specific DNA binding
AL485_RS14550	COG1448	Aminotransferase
AL485_RS14560	COG2315	Protein conserved in bacteria
AL485_RS14565	COG0110	maltose O-acetyltransferase activity
AL485_RS14570	COG1064	alcohol dehydrogenase
AL485_RS14580	COG0629	single-stranded DNA binding
AL485_RS14585	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS14590	COG0583	DNA-binding transcription factor activity
AL485_RS14600	COG0625	glutathione transferase activity
AL485_RS14610	COG2252	PERMEase
AL485_RS14615	COG0025	NhaP-type Na H and K H
AL485_RS14620	COG0583	DNA-binding transcription factor activity
AL485_RS14625	COG1380	Effector of murein hydrolase LrgA
AL485_RS14640	COG1560	Kdo2-lipid A biosynthetic process
AL485_RS14665	COG2264	protein methyltransferase activity
AL485_RS14670	COG4145	pantothenate transmembrane transporter activity
AL485_RS14675	COG3924	membrane
AL485_RS14680	COG0439	Biotin carboxylase
AL485_RS14685	COG0511	ligase activity, forming carbon-carbon bonds
AL485_RS14690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL485_RS14695	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AL485_RS14700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL485_RS14705	COG0604	alcohol dehydrogenase
AL485_RS14710	COG2199	diguanylate cyclase activity
AL485_RS14710	COG2200	EAL domain
AL485_RS14715	COG1077	Cell shape determining protein MreB Mrl
AL485_RS14720	COG1792	Involved in formation and maintenance of cell shape
AL485_RS14725	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL485_RS14730	COG0424	maF-like protein
AL485_RS14735	COG1530	ribonuclease E activity
AL485_RS14740	COG3164	Protein of unknown function
AL485_RS14745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL485_RS14750	COG0312	modulator of DNA gyrase
AL485_RS14760	COG3210	domain, Protein
AL485_RS14775	COG3210	domain, Protein
AL485_RS14790	COG0583	DNA-binding transcription factor activity
AL485_RS14800	COG1566	PFAM secretion protein HlyD family protein
AL485_RS14805	COG1289	transmembrane transporter activity
AL485_RS14815	COG2732	(Barnase) inhibitor
AL485_RS14820	COG3028	Belongs to the UPF0307 family
AL485_RS14825	COG0312	modulator of DNA gyrase
AL485_RS14830	COG3783	Cytochrome b(562)
AL485_RS14835	COG2207	Transcriptional regulator
AL485_RS14845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL485_RS14875	COG3964	amidohydrolase
AL485_RS14890	COG2706	6-phosphogluconolactonase activity
AL485_RS14895	COG3711	transcriptional antiterminator
AL485_RS14895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL485_RS14900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL485_RS14905	COG1660	Displays ATPase and GTPase activities
AL485_RS14920	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AL485_RS14925	COG1137	ATPase activity
AL485_RS14930	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL485_RS14935	COG3117	lipopolysaccharide transmembrane transporter activity
AL485_RS14940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AL485_RS14945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL485_RS14945	COG0517	IMP dehydrogenase activity
AL485_RS14950	COG0530	calcium, potassium:sodium antiporter activity
AL485_RS14955	COG1127	ABC transporter
AL485_RS14960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL485_RS14965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL485_RS14970	COG2854	intermembrane phospholipid transfer
AL485_RS14975	COG3113	response to antibiotic
AL485_RS14980	COG5007	Belongs to the BolA IbaG family
AL485_RS14985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL485_RS14990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL485_RS14995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL485_RS15000	COG3105	Protein conserved in bacteria
AL485_RS15005	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL485_RS15010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL485_RS15015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL485_RS15020	COG0625	glutathione transferase activity
AL485_RS15025	COG2969	positive regulation of protein catabolic process
AL485_RS15035	COG0493	'glutamate synthase
AL485_RS15040	COG0070	glutamate synthase
AL485_RS15040	COG0069	glutamate synthase activity
AL485_RS15040	COG0067	glutamate synthase
AL485_RS15045	COG1242	4 iron, 4 sulfur cluster binding
AL485_RS15050	COG5002	protein histidine kinase activity
AL485_RS15050	COG0784	Response regulator, receiver
AL485_RS15050	COG2198	Histidine kinase
AL485_RS15055	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL485_RS15070	COG2823	Periplasmic or secreted lipoprotein
AL485_RS15075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL485_RS15080	COG0792	nuclease activity
AL485_RS15085	COG3107	peptidoglycan biosynthetic process
AL485_RS15090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL485_RS15100	COG1741	Belongs to the pirin family
AL485_RS15105	COG0583	DNA-binding transcription factor activity
AL485_RS15110	COG0435	Glutathione S-transferase
AL485_RS15115	COG2259	Doxx family
AL485_RS15125	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
AL485_RS15130	COG4575	ribosome binding
AL485_RS15140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL485_RS15145	COG0586	Pfam SNARE associated Golgi protein
AL485_RS15160	COG2271	Major facilitator Superfamily
AL485_RS15165	COG1904	glucuronate isomerase
AL485_RS15170	COG2721	sulfolactate sulfo-lyase activity
AL485_RS15175	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL485_RS15180	COG0861	Integral membrane protein TerC family
AL485_RS15185	COG0519	Catalyzes the synthesis of GMP from XMP
AL485_RS15185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL485_RS15190	COG0673	inositol 2-dehydrogenase activity
AL485_RS15195	COG1451	nucleotide metabolic process
AL485_RS15200	COG3093	addiction module antidote protein HigA
AL485_RS15205	COG3549	Plasmid maintenance system killer
AL485_RS15210	COG2813	Specifically methylates the guanine in position
AL485_RS15215	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL485_RS15215	COG1902	pentaerythritol trinitrate reductase activity
AL485_RS15230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL485_RS15235	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS15245	COG0625	glutathione transferase activity
AL485_RS15270	COG3663	DNA glycosylase
AL485_RS15285	COG0358	DNA primase activity
AL485_RS15290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL485_RS15295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL485_RS15305	COG1132	(ABC) transporter
AL485_RS15305	COG2375	cellular response to nickel ion
AL485_RS15310	COG4774	siderophore transport
AL485_RS15315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL485_RS15320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL485_RS15325	COG1968	undecaprenyl-diphosphatase activity
AL485_RS15330	COG0617	tRNA 3'-terminal CCA addition
AL485_RS15335	COG4991	sh3 domain protein
AL485_RS15340	COG3025	triphosphatase activity
AL485_RS15345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL485_RS15350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL485_RS15350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL485_RS15355	COG0531	amino acid
AL485_RS15360	COG2960	long-chain fatty acid transporting porin activity
AL485_RS15365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL485_RS15375	COG3384	dioxygenase
AL485_RS15380	COG1609	Transcriptional regulator
AL485_RS15395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS15395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL485_RS15400	COG3715	PTS system
AL485_RS15405	COG3716	PTS system mannose fructose sorbose family IID component
AL485_RS15415	COG2140	Oxalate decarboxylase
AL485_RS15420	COG0754	glutathionylspermidine amidase activity
AL485_RS15425	COG5463	Belongs to the UPF0441 family
AL485_RS15435	COG2376	Dihydroxyacetone kinase
AL485_RS15440	COG1461	Dihydroxyacetone kinase
AL485_RS15455	COG1312	Catalyzes the dehydration of D-mannonate
AL485_RS15460	COG1538	Outer membrane efflux protein
AL485_RS15465	COG0494	nUDIX hydrolase
AL485_RS15470	COG3151	Protein conserved in bacteria
AL485_RS15475	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AL485_RS15480	COG3150	esterase
AL485_RS15490	COG0583	DNA-binding transcription factor activity
AL485_RS15495	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL485_RS15500	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL485_RS15510	COG0204	Acyl-transferase
AL485_RS15515	COG2132	Multicopper oxidase
AL485_RS15520	COG0583	DNA-binding transcription factor activity
AL485_RS15525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL485_RS15530	COG2211	Major facilitator Superfamily
AL485_RS15535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL485_RS15545	COG0741	lytic transglycosylase activity
AL485_RS15550	COG1940	carbohydrate kinase activity
AL485_RS15555	COG0457	Tetratricopeptide repeat
AL485_RS15560	COG0477	Major facilitator Superfamily
AL485_RS15560	COG2814	Major facilitator Superfamily
AL485_RS15565	COG1879	ABC-type sugar transport system periplasmic component
AL485_RS15570	COG1129	ABC transporter
AL485_RS15580	COG1063	alcohol dehydrogenase
AL485_RS15585	COG2017	converts alpha-aldose to the beta-anomer
AL485_RS15595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL485_RS15600	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL485_RS15605	COG2723	6-phospho-beta-galactosidase activity
AL485_RS15615	COG0402	S-adenosylhomocysteine deaminase activity
AL485_RS15620	COG0656	L-ascorbic acid biosynthetic process
AL485_RS15625	COG1979	alcohol dehydrogenase
AL485_RS15630	COG2207	Transcriptional regulator
AL485_RS15635	COG3321	synthase
AL485_RS15635	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS15635	COG0604	alcohol dehydrogenase
AL485_RS15640	COG0583	DNA-binding transcription factor activity
AL485_RS15645	COG0586	Pfam SNARE associated Golgi protein
AL485_RS15660	COG0848	biopolymer transport protein
AL485_RS15665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL485_RS15695	COG2831	hemolysin activation secretion protein
AL485_RS15700	COG2994	toxin metabolic process
AL485_RS15705	COG3210	domain, Protein
AL485_RS15725	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL485_RS15730	COG1473	amidohydrolase
AL485_RS15735	COG1473	amidohydrolase
AL485_RS15740	COG0583	DNA-binding transcription factor activity
AL485_RS15745	COG4772	TonB-dependent receptor
AL485_RS15760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL485_RS15760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL485_RS15785	COG0454	-acetyltransferase
AL485_RS15815	COG2003	Belongs to the UPF0758 family
AL485_RS15830	COG0859	PFAM glycosyl transferase family 9
AL485_RS15860	COG2378	regulation of single-species biofilm formation
AL485_RS15865	COG3596	GTP binding
AL485_RS15920	COG0791	NLP P60 protein
AL485_RS15925	COG3753	Protein conserved in bacteria
AL485_RS15945	COG0582	viral genome integration into host DNA
AL485_RS15975	COG3121	Chaperone
AL485_RS15980	COG3121	Chaperone
AL485_RS15985	COG3188	usher protein
AL485_RS16070	COG4974	Belongs to the 'phage' integrase family
AL485_RS16080	COG3436	PFAM IS66 Orf2 family protein
AL485_RS16110	COG0582	viral genome integration into host DNA
AL485_RS16120	COG1982	Orn Lys Arg decarboxylase major
AL485_RS16125	COG0741	lytic transglycosylase activity
AL485_RS16130	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL485_RS16140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL485_RS16145	COG3171	Protein conserved in bacteria
AL485_RS16150	COG2066	Belongs to the glutaminase family
AL485_RS16170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL485_RS16175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL485_RS16180	COG1872	DUF167
AL485_RS16185	COG0762	integral membrane protein
AL485_RS16190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL485_RS16195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL485_RS16200	COG2805	Type II/IV secretion system protein
AL485_RS16205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL485_RS16210	COG1678	Uncharacterized ACR, COG1678
AL485_RS16215	COG0189	ligase activity
AL485_RS16220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL485_RS16225	COG2356	endonuclease I
AL485_RS16230	COG3091	SprT-like family
AL485_RS16235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AL485_RS16235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AL485_RS16240	COG3708	Transcriptional regulator
AL485_RS16240	COG2207	Transcriptional regulator
AL485_RS16245	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AL485_RS16255	COG2010	Cytochrome c
AL485_RS16255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL485_RS16265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL485_RS16265	COG2010	Cytochrome c
AL485_RS16270	COG1113	amino acid transport
AL485_RS16275	COG2186	Transcriptional regulator
AL485_RS16280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL485_RS16285	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL485_RS16290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL485_RS16300	COG3112	Uncharacterised protein family (UPF0231)
AL485_RS16305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AL485_RS16310	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AL485_RS16320	COG2132	Multicopper oxidase
AL485_RS16330	COG0288	reversible hydration of carbon dioxide
AL485_RS16335	COG1131	(ABC) transporter
AL485_RS16340	COG0842	Transport permease protein
AL485_RS16345	COG0726	polysaccharide deacetylase
AL485_RS16350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AL485_RS16355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL485_RS16360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL485_RS16370	COG0642	Histidine kinase
AL485_RS16375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL485_RS16380	COG0617	tRNA 3'-terminal CCA addition
AL485_RS16385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL485_RS16395	COG1489	DNA binding
AL485_RS16400	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AL485_RS16405	COG1643	Atp-dependent helicase
AL485_RS16410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL485_RS16415	COG4774	siderophore transport
AL485_RS16420	COG1120	ATPase activity
AL485_RS16425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL485_RS16430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL485_RS16440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL485_RS16445	COG1166	arginine decarboxylase activity
AL485_RS16455	COG0010	Belongs to the arginase family
AL485_RS16460	COG1187	pseudouridine synthase activity
AL485_RS16465	COG2271	Major facilitator Superfamily
AL485_RS16470	COG2146	nitrite reductase [NAD(P)H] activity
AL485_RS16490	COG1414	Transcriptional regulator
AL485_RS16505	COG2271	Major facilitator Superfamily
AL485_RS16515	COG2267	carboxylic ester hydrolase activity
AL485_RS16520	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS16525	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AL485_RS16540	COG0501	Belongs to the peptidase M48B family
AL485_RS16545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL485_RS16555	COG1175	transmembrane transport
AL485_RS16560	COG3842	ATPase activity
AL485_RS16565	COG0473	3-isopropylmalate dehydrogenase activity
AL485_RS16570	COG0583	DNA-binding transcription factor activity
AL485_RS16575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL485_RS16580	COG0126	phosphoglycerate kinase activity
AL485_RS16585	COG0191	fructose-bisphosphate aldolase activity
AL485_RS16600	COG2271	Major facilitator Superfamily
AL485_RS16610	COG0235	Class ii aldolase
AL485_RS16615	COG3623	hexulose-6-phosphate isomerase
AL485_RS16620	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL485_RS16625	COG1070	Carbohydrate kinase
AL485_RS16635	COG2731	YhcH YjgK YiaL family protein
AL485_RS16655	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS16660	COG1129	ABC transporter
AL485_RS16665	COG1414	Transcriptional regulator
AL485_RS16670	COG1279	arginine transmembrane transporter activity
AL485_RS16680	COG0583	DNA-binding transcription factor activity
AL485_RS16685	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL485_RS16690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL485_RS16695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL485_RS16705	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL485_RS16710	COG3079	Belongs to the UPF0149 family
AL485_RS16715	COG0006	proline dipeptidase activity
AL485_RS16720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL485_RS16725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL485_RS16730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL485_RS16735	COG0509	glycine decarboxylation via glycine cleavage system
AL485_RS16740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL485_RS16740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL485_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS16815	COG1272	protein, Hemolysin III
AL485_RS16825	COG0354	folic acid binding
AL485_RS16830	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL485_RS16840	COG0745	RESPONSE REGULATOR receiver
AL485_RS16845	COG2205	protein histidine kinase activity
AL485_RS16850	COG4452	Inner membrane protein CreD
AL485_RS16855	COG0716	FMN binding
AL485_RS16860	COG4974	Belongs to the 'phage' integrase family
AL485_RS16865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL485_RS16870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL485_RS16875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL485_RS16880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL485_RS16925	COG3539	Fimbrial protein
AL485_RS16930	COG3121	Chaperone
AL485_RS16935	COG3188	usher protein
AL485_RS16945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL485_RS16955	COG2186	Transcriptional regulator
AL485_RS16965	COG2197	response regulator
AL485_RS16985	COG0484	heat shock protein binding
AL485_RS16990	COG3247	response to pH
AL485_RS17000	COG1335	isochorismatase
AL485_RS17005	COG5265	(ABC) transporter
AL485_RS17010	COG1942	4-Oxalocrotonate Tautomerase
AL485_RS17020	COG1304	FMN binding
AL485_RS17025	COG1620	l-lactate permease
AL485_RS17035	COG4615	Cyclic peptide transporter
AL485_RS17040	COG2807	transmembrane transport
AL485_RS17045	COG1349	DNA-binding transcription factor activity
AL485_RS17055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS17060	COG3715	PTS system
AL485_RS17065	COG3716	PTS system mannose fructose sorbose family IID component
AL485_RS17075	COG4178	(ABC) transporter
AL485_RS17095	COG0583	DNA-binding transcription factor activity
AL485_RS17100	COG2814	Major facilitator Superfamily
AL485_RS17105	COG0583	DNA-binding transcription factor activity
AL485_RS17135	COG1609	Transcriptional regulator
AL485_RS17145	COG0204	Acyl-transferase
AL485_RS17145	COG0318	PFAM AMP-dependent synthetase and ligase
AL485_RS17150	COG0477	Major facilitator Superfamily
AL485_RS17155	COG0667	Aldo Keto reductase
AL485_RS17165	COG0861	Integral membrane protein TerC family
AL485_RS17170	COG3066	DNA modification
AL485_RS17175	COG0494	nUDIX hydrolase
AL485_RS17185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL485_RS17190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL485_RS17215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL485_RS17220	COG1025	Belongs to the peptidase M16 family
AL485_RS17225	COG1074	ATP-dependent DNA helicase activity
AL485_RS17230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL485_RS17235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL485_RS17235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL485_RS17240	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL485_RS17265	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL485_RS17270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL485_RS17280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL485_RS17290	COG0583	DNA-binding transcription factor activity
AL485_RS17295	COG2363	Small membrane protein
AL485_RS17300	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AL485_RS17305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL485_RS17310	COG1611	Belongs to the LOG family
AL485_RS17320	COG3098	single-species biofilm formation
AL485_RS17325	COG2373	Large extracellular alpha-helical protein
AL485_RS17330	COG4953	penicillin-binding protein 1C
AL485_RS17335	COG0564	pseudouridine synthase activity
AL485_RS17355	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL485_RS17365	COG0052	Belongs to the universal ribosomal protein uS2 family
AL485_RS17370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL485_RS17375	COG0528	UMP kinase activity
AL485_RS17380	COG0233	cytoplasmic translational termination
AL485_RS17385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL485_RS17390	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL485_RS17395	COG0575	Belongs to the CDS family
AL485_RS17400	COG0750	zinc metalloprotease
AL485_RS17405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL485_RS17410	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL485_RS17415	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL485_RS17420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL485_RS17425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL485_RS17430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL485_RS17435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL485_RS17445	COG0825	malonyl-CoA metabolic process
AL485_RS17450	COG1982	Orn Lys Arg decarboxylase major
AL485_RS17465	COG0346	lactoylglutathione lyase activity
AL485_RS17470	COG3710	Transcriptional regulator
AL485_RS17475	COG0531	amino acid
AL485_RS17485	COG3104	oligopeptide transport
AL485_RS17490	COG0037	tRNA processing
AL485_RS17500	COG4568	rho-dependent transcription termination
AL485_RS17515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL485_RS17520	COG3015	lipoprotein NlpE involved in copper resistance
AL485_RS17525	COG0442	prolyl-tRNA aminoacylation
AL485_RS17530	COG1720	tRNA m6t6A37 methyltransferase activity
AL485_RS17555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL485_RS17585	COG0477	Major facilitator Superfamily
AL485_RS17590	COG5544	Lipoprotein
AL485_RS17595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL485_RS17600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL485_RS17600	COG1042	CoA-binding domain protein
AL485_RS17600	COG0045	succinate-CoA ligase (ADP-forming) activity
AL485_RS17605	COG3148	PFAM DTW domain containing protein
AL485_RS17610	COG3118	belongs to the thioredoxin family
AL485_RS17615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL485_RS17620	COG2814	Major facilitator Superfamily
AL485_RS17625	COG1566	PFAM secretion protein HlyD family protein
AL485_RS17630	COG1538	Outer membrane efflux protein
AL485_RS17635	COG1846	Transcriptional regulator
AL485_RS17650	COG2814	Major facilitator Superfamily
AL485_RS17655	COG0583	DNA-binding transcription factor activity
AL485_RS17660	COG2113	Glycine betaine
AL485_RS17665	COG2113	Glycine betaine
AL485_RS17670	COG4176	ABC-type proline glycine betaine transport system permease component
AL485_RS17675	COG4175	Glycine betaine
AL485_RS17690	COG3493	citrate carrier protein
AL485_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS17725	COG1780	Probably involved in ribonucleotide reductase function
AL485_RS17730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL485_RS17735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL485_RS17745	COG4575	ribosome binding
AL485_RS17765	COG0583	DNA-binding transcription factor activity
AL485_RS17775	COG2207	Transcriptional regulator
AL485_RS17775	COG3708	Transcriptional regulator
AL485_RS17795	COG2840	Smr protein MutS2
AL485_RS17800	COG2259	Doxx family
AL485_RS17805	COG2388	GCN5-related N-acetyl-transferase
AL485_RS17815	COG2226	methyltransferase
AL485_RS17830	COG3713	MltA-interacting MipA family protein
AL485_RS17835	COG0583	DNA-binding transcription factor activity
AL485_RS17850	COG1566	PFAM secretion protein HlyD family protein
AL485_RS17865	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS17905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL485_RS17910	COG2867	negative regulation of translational initiation
AL485_RS17915	COG2914	Belongs to the UPF0125 (RnfH) family
AL485_RS17925	COG0497	DNA recombination
AL485_RS17930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL485_RS17935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL485_RS17940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL485_RS17945	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL485_RS17960	COG0513	Belongs to the DEAD box helicase family
AL485_RS17965	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL485_RS17970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL485_RS17985	COG3026	antisigma factor binding
AL485_RS17990	COG3086	response to oxidative stress
AL485_RS18010	COG3561	AntA/AntB antirepressor
AL485_RS18110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL485_RS18305	COG0481	GTPase activity
AL485_RS18310	COG0681	Belongs to the peptidase S26 family
AL485_RS18315	COG0571	ribonuclease III activity
AL485_RS18320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL485_RS18325	COG1381	Involved in DNA repair and RecF pathway recombination
AL485_RS18330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL485_RS18335	COG0736	holo-[acyl-carrier-protein] synthase activity
AL485_RS18340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL485_RS18345	COG1737	Transcriptional regulator
AL485_RS18350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL485_RS18355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS18355	COG1263	PTS System
AL485_RS18360	COG0560	Phosphoserine phosphatase
AL485_RS18365	COG1454	alcohol dehydrogenase
AL485_RS18380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL485_RS18390	COG2205	protein histidine kinase activity
AL485_RS18395	COG3170	Tfp pilus assembly protein FimV
AL485_RS18400	COG2204	response regulator
AL485_RS18405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL485_RS18405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL485_RS18410	COG0347	Belongs to the P(II) protein family
AL485_RS18430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL485_RS18435	COG3842	ATPase activity
AL485_RS18440	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL485_RS18445	COG1177	transmembrane transport
AL485_RS18450	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS18455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AL485_RS18465	COG1017	nitric oxide dioxygenase activity
AL485_RS18465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL485_RS18470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL485_RS18475	COG2814	Major facilitator Superfamily
AL485_RS18480	COG3711	transcriptional antiterminator
AL485_RS18485	COG3683	transport system, periplasmic component
AL485_RS18490	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AL485_RS18505	COG1959	2 iron, 2 sulfur cluster binding
AL485_RS18510	COG1104	cysteine desulfurase activity
AL485_RS18515	COG0822	iron-sulfur transferase activity
AL485_RS18520	COG0316	Belongs to the HesB IscA family
AL485_RS18525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL485_RS18530	COG0443	Heat shock 70 kDa protein
AL485_RS18535	COG0633	Ferredoxin
AL485_RS18540	COG2975	iron-sulfur cluster assembly
AL485_RS18545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL485_RS18555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL485_RS18560	COG1757	Na H antiporter
AL485_RS18565	COG1609	Transcriptional regulator
AL485_RS18570	COG0105	UTP biosynthetic process
AL485_RS18575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL485_RS18585	COG1426	Protein conserved in bacteria
AL485_RS18590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL485_RS18595	COG0124	histidyl-tRNA synthetase
AL485_RS18600	COG2976	Protein conserved in bacteria
AL485_RS18605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL485_RS18610	COG1160	GTP binding
AL485_RS18640	COG2271	Major facilitator Superfamily
AL485_RS18650	COG1570	exodeoxyribonuclease VII activity
AL485_RS18655	COG0517	IMP dehydrogenase activity
AL485_RS18655	COG0516	GMP reductase activity
AL485_RS18660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL485_RS18660	COG0519	Catalyzes the synthesis of GMP from XMP
AL485_RS18680	COG1733	regulation of RNA biosynthetic process
AL485_RS18690	COG0784	Response regulator, receiver
AL485_RS18690	COG2205	protein histidine kinase activity
AL485_RS18690	COG2198	Histidine kinase
AL485_RS18695	COG2197	response regulator
AL485_RS18735	COG2188	Transcriptional regulator
AL485_RS18740	COG1082	Xylose isomerase domain protein TIM barrel
AL485_RS18745	COG2271	Major facilitator Superfamily
AL485_RS18755	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL485_RS18760	COG0351	phosphomethylpyrimidine kinase
AL485_RS18780	COG1349	DNA-binding transcription factor activity
AL485_RS18785	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL485_RS18790	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS18805	COG3730	PTS system glucitol sorbitol-specific
AL485_RS18810	COG1830	Aldolase
AL485_RS18815	COG1802	Transcriptional regulator
AL485_RS18820	COG0246	Mannitol dehydrogenase
AL485_RS18825	COG2271	Major facilitator Superfamily
AL485_RS18830	COG1063	alcohol dehydrogenase
AL485_RS18835	COG4948	Mandelate Racemase Muconate Lactonizing
AL485_RS18840	COG1597	lipid kinase activity
AL485_RS18850	COG3422	double-strand break repair
AL485_RS18865	COG0745	RESPONSE REGULATOR receiver
AL485_RS18870	COG2205	protein histidine kinase activity
AL485_RS18875	COG2814	Major facilitator Superfamily
AL485_RS18880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL485_RS18885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL485_RS18890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS18895	COG0667	Aldo Keto reductase
AL485_RS18905	COG0443	Heat shock 70 kDa protein
AL485_RS18910	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL485_RS18920	COG3447	MASE1 domain protein
AL485_RS18920	COG5002	protein histidine kinase activity
AL485_RS18920	COG5001	Diguanylate cyclase
AL485_RS18935	COG2200	EAL domain
AL485_RS18945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL485_RS18950	COG0573	inorganic phosphate transmembrane transporter activity
AL485_RS18955	COG0573	inorganic phosphate transmembrane transporter activity
AL485_RS19000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL485_RS19005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL485_RS19010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL485_RS19015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL485_RS19020	COG2233	PERMEase
AL485_RS19025	COG2261	transglycosylase associated protein
AL485_RS19035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL485_RS19040	COG1393	Belongs to the ArsC family
AL485_RS19045	COG4783	chaperone-mediated protein folding
AL485_RS19075	COG2005	Transcriptional regulator
AL485_RS19075	COG3585	molybdate ion transport
AL485_RS19090	COG0628	permease
AL485_RS19095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL485_RS19100	COG2716	regulation of RNA biosynthetic process
AL485_RS19105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL485_RS19110	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL485_RS19115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL485_RS19120	COG2321	neutral zinc metallopeptidase
AL485_RS19125	COG1444	tRNA N-acetyltransferase activity
AL485_RS19130	COG0400	carboxylic ester hydrolase activity
AL485_RS19140	COG1876	peptidase activity
AL485_RS19145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL485_RS19150	COG1393	Belongs to the ArsC family
AL485_RS19165	COG0456	acetyltransferase
AL485_RS19185	COG4771	TonB-dependent receptor
AL485_RS19190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL485_RS19200	COG2197	response regulator
AL485_RS19205	COG3850	Histidine kinase
AL485_RS19210	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL485_RS19210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL485_RS19215	COG3062	negative regulation of establishment of protein localization
AL485_RS19220	COG0243	molybdopterin cofactor binding
AL485_RS19225	COG3043	anaerobic respiration
AL485_RS19230	COG3005	denitrification pathway
AL485_RS19235	COG0494	nUDIX hydrolase
AL485_RS19240	COG2207	Transcriptional regulator
AL485_RS19240	COG3708	Transcriptional regulator
AL485_RS19245	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AL485_RS19250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL485_RS19255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL485_RS19260	COG3397	chitin binding
AL485_RS19265	COG0583	DNA-binding transcription factor activity
AL485_RS19300	COG2040	homocysteine
AL485_RS19305	COG0833	amino acid
AL485_RS19320	COG1770	oligopeptidase
AL485_RS19330	COG1671	Belongs to the UPF0178 family
AL485_RS19335	COG0408	coproporphyrinogen oxidase activity
AL485_RS19345	COG0456	acetyltransferase
AL485_RS19350	COG3111	PFAM Bacterial OB fold (BOF) protein
AL485_RS19365	COG2837	iron assimilation
AL485_RS19370	COG4150	thiosulfate binding
AL485_RS19375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AL485_RS19380	COG4208	sulfate ABC transporter
AL485_RS19390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL485_RS19400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS19405	COG0745	RESPONSE REGULATOR receiver
AL485_RS19410	COG2205	protein histidine kinase activity
AL485_RS19420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL485_RS19425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL485_RS19435	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL485_RS19440	COG3115	cell septum assembly
AL485_RS19445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL485_RS19450	COG3530	Putative quorum-sensing-regulated virulence factor
AL485_RS19455	COG0385	Bile acid
AL485_RS19460	COG0583	DNA-binding transcription factor activity
AL485_RS19475	COG4303	Ethanolamine ammonia lyase large subunit
AL485_RS19480	COG4302	ethanolamine ammonia-lyase activity
AL485_RS19500	COG0747	negative chemotaxis
AL485_RS19510	COG2382	esterase
AL485_RS19515	COG3251	PFAM MbtH domain protein
AL485_RS19520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL485_RS19520	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AL485_RS19525	COG1120	ATPase activity
AL485_RS19530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL485_RS19535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL485_RS19545	COG4592	Periplasmic binding protein
AL485_RS19550	COG1169	isochorismate synthase
AL485_RS19555	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL485_RS19560	COG3433	isochorismatase activity
AL485_RS19560	COG1535	isochorismatase
AL485_RS19565	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS19595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL485_RS19600	COG2116	formate transmembrane transporter activity
AL485_RS19615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL485_RS19620	COG1914	H( )-stimulated, divalent metal cation uptake system
AL485_RS19630	COG0667	Aldo Keto reductase
AL485_RS19635	COG3961	Belongs to the TPP enzyme family
AL485_RS19650	COG1794	racemase activity, acting on amino acids and derivatives
AL485_RS19665	COG2223	nitrite transmembrane transporter activity
AL485_RS19675	COG3279	Response regulator of the LytR AlgR family
AL485_RS19680	COG3275	phosphorelay sensor kinase activity
AL485_RS19695	COG0436	Aminotransferase
AL485_RS19700	COG3038	cytochrome b561
AL485_RS19705	COG1598	PFAM Uncharacterised protein family UPF0150
AL485_RS19715	COG2951	lytic endotransglycosylase activity
AL485_RS19740	COG0583	DNA-binding transcription factor activity
AL485_RS19745	COG3122	Protein conserved in bacteria
AL485_RS19755	COG2116	formate transmembrane transporter activity
AL485_RS19770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL485_RS19775	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL485_RS19780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL485_RS19785	COG1138	Cytochrome C-type biogenesis protein
AL485_RS19790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL485_RS19795	COG3088	subunit of a heme lyase
AL485_RS19795	COG4235	cytochrome complex assembly
AL485_RS19800	COG3088	subunit of a heme lyase
AL485_RS19800	COG4235	cytochrome complex assembly
AL485_RS19815	COG3691	Protein conserved in bacteria
AL485_RS19825	COG1024	Enoyl-CoA hydratase
AL485_RS19825	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL485_RS19830	COG2062	phosphohistidine phosphatase, SixA
AL485_RS19835	COG2840	Smr protein MutS2
AL485_RS19840	COG2890	protein-(glutamine-N5) methyltransferase activity
AL485_RS19845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL485_RS19850	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AL485_RS19855	COG0730	response to heat
AL485_RS19860	COG3101	peptidyl-lysine hydroxylation
AL485_RS19870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL485_RS19870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL485_RS19875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL485_RS19900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS19905	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL485_RS19910	COG1477	protein flavinylation
AL485_RS19915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL485_RS19920	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL485_RS19965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL485_RS19970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL485_RS20010	COG0642	Histidine kinase
AL485_RS20015	COG0697	spore germination
AL485_RS20025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL485_RS20030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL485_RS20040	COG0586	Pfam SNARE associated Golgi protein
AL485_RS20045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL485_RS20050	COG0285	dihydrofolate synthase activity
AL485_RS20055	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL485_RS20060	COG1286	toxin biosynthetic process
AL485_RS20065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL485_RS20070	COG0163	prenyltransferase activity
AL485_RS20075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS20080	COG4215	(ABC) transporter
AL485_RS20090	COG4598	ABC transporter
AL485_RS20095	COG1090	epimerase
AL485_RS20100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL485_RS20105	COG0625	glutathione transferase activity
AL485_RS20110	COG0622	Phosphoesterase
AL485_RS20115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AL485_RS20120	COG0280	phosphate acetyltransferase
AL485_RS20120	COG0857	belongs to the CobB CobQ family
AL485_RS20125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL485_RS20130	COG3092	negative regulation of chromosome organization
AL485_RS20135	COG3013	Belongs to the UPF0304 family
AL485_RS20140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL485_RS20145	COG0490	domain, Protein
AL485_RS20145	COG0471	metal ion transport
AL485_RS20150	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL485_RS20155	COG0436	Aminotransferase
AL485_RS20160	COG0583	DNA-binding transcription factor activity
AL485_RS20165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL485_RS20170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL485_RS20175	COG0649	NAD binding
AL485_RS20175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL485_RS20190	COG1034	ATP synthesis coupled electron transport
AL485_RS20195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AL485_RS20205	COG0839	Belongs to the complex I subunit 6 family
AL485_RS20210	COG0713	ATP synthesis coupled electron transport
AL485_RS20215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL485_RS20220	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL485_RS20225	COG1007	ATP synthesis coupled electron transport
AL485_RS20235	COG0028	Belongs to the TPP enzyme family
AL485_RS20260	COG1609	Transcriptional regulator
AL485_RS20265	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS20270	COG1063	alcohol dehydrogenase
AL485_RS20275	COG4575	ribosome binding
AL485_RS20280	COG3459	Glycosyltransferase 36 associated
AL485_RS20285	COG1169	isochorismate synthase
AL485_RS20290	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL485_RS20295	COG0596	Alpha beta hydrolase
AL485_RS20300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL485_RS20325	COG0814	amino acid
AL485_RS20335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL485_RS20340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL485_RS20350	COG2721	sulfolactate sulfo-lyase activity
AL485_RS20360	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS20365	COG1063	alcohol dehydrogenase
AL485_RS20370	COG2271	Major facilitator Superfamily
AL485_RS20375	COG2271	Major facilitator Superfamily
AL485_RS20380	COG0473	3-isopropylmalate dehydrogenase activity
AL485_RS20380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL485_RS20390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL485_RS20400	COG2205	protein histidine kinase activity
AL485_RS20400	COG0784	Response regulator, receiver
AL485_RS20410	COG2198	Histidine kinase
AL485_RS20410	COG0642	Histidine kinase
AL485_RS20430	COG0346	lactoylglutathione lyase activity
AL485_RS20465	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL485_RS20495	COG3082	Protein of unknown function (DUF1414)
AL485_RS20500	COG3081	Nucleoid-associated protein
AL485_RS20505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL485_RS20515	COG1187	pseudouridine synthase activity
AL485_RS20520	COG2814	Major facilitator Superfamily
AL485_RS20530	COG4172	Belongs to the ABC transporter superfamily
AL485_RS20535	COG4239	(ABC) transporter, permease
AL485_RS20540	COG4174	ABC transporter (Permease)
AL485_RS20555	COG0791	NLP P60 protein
AL485_RS20560	COG0671	phosphoesterase, PA-phosphatase related
AL485_RS20565	COG0523	cobalamin synthesis protein
AL485_RS20575	COG0246	Mannitol dehydrogenase
AL485_RS20580	COG1312	Catalyzes the dehydration of D-mannonate
AL485_RS20585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL485_RS20605	COG0243	molybdopterin cofactor binding
AL485_RS20610	COG3005	denitrification pathway
AL485_RS20615	COG0494	nUDIX hydrolase
AL485_RS20625	COG1105	Belongs to the carbohydrate kinase PfkB family
AL485_RS20635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL485_RS20640	COG2855	membrane
AL485_RS20645	COG0583	DNA-binding transcription factor activity
AL485_RS20650	COG0833	amino acid
AL485_RS20660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL485_RS20675	COG4771	TonB-dependent receptor
AL485_RS20680	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL485_RS20685	COG1129	ABC transporter
AL485_RS20690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL485_RS20695	COG1917	Cupin 2, conserved barrel domain protein
AL485_RS20695	COG1396	sequence-specific DNA binding
AL485_RS20700	COG0174	glutamine synthetase
AL485_RS20705	COG0531	amino acid
AL485_RS20710	COG2925	Exonuclease
AL485_RS20735	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL485_RS20740	COG1289	transmembrane transporter activity
AL485_RS20745	COG2926	Belongs to the UPF0265 family
AL485_RS20750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS20755	COG1473	amidohydrolase
AL485_RS20790	COG0411	ABC transporter
AL485_RS20805	COG1609	Transcriptional regulator
AL485_RS20810	COG0673	inositol 2-dehydrogenase activity
AL485_RS20815	COG1082	Xylose isomerase domain protein TIM barrel
AL485_RS20825	COG2271	Major facilitator Superfamily
AL485_RS20830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL485_RS20840	COG4122	O-methyltransferase activity
AL485_RS20850	COG3250	beta-galactosidase activity
AL485_RS20855	COG4565	transcriptional regulatory protein
AL485_RS20860	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AL485_RS20865	COG3052	prosthetic group binding
AL485_RS20870	COG2301	Belongs to the HpcH HpaI aldolase family
AL485_RS20875	COG3051	citrate lyase alpha subunit
AL485_RS20890	COG0471	metal ion transport
AL485_RS20900	COG2977	Belongs to the P-Pant transferase superfamily
AL485_RS20920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL485_RS20930	COG0747	negative chemotaxis
AL485_RS20935	COG0601	transmembrane transport
AL485_RS20940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL485_RS20945	COG4172	Belongs to the ABC transporter superfamily
AL485_RS20950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS20965	COG0583	DNA-binding transcription factor activity
AL485_RS20990	COG3238	Protein conserved in bacteria
AL485_RS21005	COG0583	DNA-binding transcription factor activity
AL485_RS21045	COG0642	Histidine kinase
AL485_RS21055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS21070	COG3781	membrane
AL485_RS21075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL485_RS21090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL485_RS21095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL485_RS21100	COG1116	anion transmembrane transporter activity
AL485_RS21105	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL485_RS21110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS21120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL485_RS21130	COG3842	ATPase activity
AL485_RS21140	COG1840	ABC-type Fe3 transport system, periplasmic component
AL485_RS21145	COG1609	Transcriptional regulator
AL485_RS21170	COG0583	DNA-binding transcription factor activity
AL485_RS21175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL485_RS21185	COG3228	Belongs to the MtfA family
AL485_RS21195	COG4977	sequence-specific DNA binding
AL485_RS21200	COG1335	isochorismatase
AL485_RS21235	COG0795	lipopolysaccharide-transporting ATPase activity
AL485_RS21240	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL485_RS21250	COG2244	polysaccharide biosynthetic process
AL485_RS21260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL485_RS21265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL485_RS21270	COG0156	8-amino-7-oxononanoate synthase activity
AL485_RS21275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL485_RS21290	COG0456	acetyltransferase
AL485_RS21300	COG0534	Mate efflux family protein
AL485_RS21310	COG1486	melibiose metabolic process
AL485_RS21315	COG2223	nitrite transmembrane transporter activity
AL485_RS21325	COG4993	Dehydrogenase
AL485_RS21330	COG0667	Aldo Keto reductase
AL485_RS21360	COG0625	glutathione transferase activity
AL485_RS21365	COG0583	DNA-binding transcription factor activity
AL485_RS21385	COG1113	amino acid transport
AL485_RS21390	COG0697	spore germination
AL485_RS21400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL485_RS21405	COG3327	negative regulation of DNA-templated transcription, initiation
AL485_RS21410	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AL485_RS21415	COG0183	Belongs to the thiolase family
AL485_RS21420	COG2050	protein possibly involved in aromatic compounds catabolism
AL485_RS21430	COG1024	Enoyl-CoA hydratase
AL485_RS21435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL485_RS21440	COG2151	metal-sulfur cluster biosynthetic enzyme
AL485_RS21445	COG3396	Phenylacetate-CoA oxygenase
AL485_RS21450	COG3460	Phenylacetate-CoA oxygenase
AL485_RS21455	COG3396	Phenylacetate-CoA oxygenase
AL485_RS21460	COG2030	dehydratase
AL485_RS21460	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS21465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL485_RS21475	COG5001	Diguanylate cyclase
AL485_RS21475	COG4251	negative regulation of phosphorylation
AL485_RS21475	COG3706	GGDEF domain
AL485_RS21475	COG2203	Gaf domain
AL485_RS21485	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AL485_RS21490	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS21495	COG0583	DNA-binding transcription factor activity
AL485_RS21500	COG2261	transglycosylase associated protein
AL485_RS21505	COG3753	Protein conserved in bacteria
AL485_RS21525	COG3321	synthase
AL485_RS21525	COG0604	alcohol dehydrogenase
AL485_RS21525	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS21540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL485_RS21560	COG0076	glutamate decarboxylase activity
AL485_RS21570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL485_RS21580	COG1285	pathogenesis
AL485_RS21625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL485_RS21635	COG0431	NADPH-dependent FMN reductase
AL485_RS21640	COG2837	iron assimilation
AL485_RS21665	COG0156	8-amino-7-oxononanoate synthase activity
AL485_RS21675	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AL485_RS21680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL485_RS21695	COG3483	tryptophan 2,3-dioxygenase activity
AL485_RS21700	COG0583	DNA-binding transcription factor activity
AL485_RS21710	COG2130	NADP-dependent
AL485_RS21745	COG0643	Histidine kinase
AL485_RS21745	COG2198	Histidine kinase
AL485_RS21750	COG0835	chemotaxis
AL485_RS21755	COG0840	transmembrane signaling receptor activity
AL485_RS21760	COG0840	transmembrane signaling receptor activity
AL485_RS21765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL485_RS21775	COG0745	RESPONSE REGULATOR receiver
AL485_RS21780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL485_RS21785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL485_RS21790	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL485_RS21805	COG0583	DNA-binding transcription factor activity
AL485_RS21810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL485_RS21820	COG3418	PFAM FlgN family protein
AL485_RS21825	COG2747	anti-sigma28 factor FlgM
AL485_RS21835	COG1815	bacterial-type flagellum-dependent cell motility
AL485_RS21840	COG1558	bacterial-type flagellum-dependent cell motility
AL485_RS21845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL485_RS21880	COG1256	bacterial-type flagellum assembly
AL485_RS21895	COG1987	bacterial-type flagellum assembly
AL485_RS21930	COG2882	bacterial-type flagellum organization
AL485_RS21935	COG1157	protein secretion by the type III secretion system
AL485_RS21940	COG1317	bacterial-type flagellum organization
AL485_RS21945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL485_RS21955	COG1677	Flagellar hook-basal body complex protein FliE
AL485_RS21985	COG1191	sigma factor activity
AL485_RS21995	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AL485_RS22000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL485_RS22005	COG0765	amino acid transport
AL485_RS22010	COG1126	abc transporter atp-binding protein
AL485_RS22025	COG0506	proline dehydrogenase activity
AL485_RS22025	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AL485_RS22025	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AL485_RS22035	COG0672	)-iron permease
AL485_RS22040	COG2822	iron ion transport
AL485_RS22050	COG4772	TonB-dependent receptor
AL485_RS22055	COG1702	phosphate starvation-inducible protein PhoH
AL485_RS22065	COG0437	4 iron, 4 sulfur cluster binding
AL485_RS22070	COG0243	molybdopterin cofactor binding
AL485_RS22080	COG0387	Pfam Sodium calcium exchanger
AL485_RS22090	COG4572	Cation transport regulator
AL485_RS22095	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AL485_RS22100	COG0583	DNA-binding transcription factor activity
AL485_RS22110	COG4166	transmembrane transport
AL485_RS22115	COG0601	transmembrane transport
AL485_RS22120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL485_RS22125	COG0444	Belongs to the ABC transporter superfamily
AL485_RS22130	COG4608	Belongs to the ABC transporter superfamily
AL485_RS22150	COG4932	domain protein
AL485_RS22155	COG2197	response regulator
AL485_RS22160	COG3850	Histidine kinase
AL485_RS22165	COG2223	nitrite transmembrane transporter activity
AL485_RS22170	COG3710	Transcriptional regulator
AL485_RS22175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL485_RS22180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL485_RS22190	COG0489	protein tyrosine kinase activity
AL485_RS22190	COG3206	protein involved in exopolysaccharide biosynthesis
AL485_RS22210	COG0438	transferase activity, transferring glycosyl groups
AL485_RS22225	COG1216	Glycosyl transferase, family 2
AL485_RS22230	COG1216	Glycosyl transferase, family 2
AL485_RS22230	COG0463	Glycosyl transferase, family 2
AL485_RS22240	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL485_RS22245	COG1140	nitrate reductase beta subunit
AL485_RS22250	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AL485_RS22255	COG2181	nitrate reductase activity
AL485_RS22260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL485_RS22310	COG1294	oxidase, subunit
AL485_RS22315	COG1271	oxidase subunit
AL485_RS22320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL485_RS22330	COG0601	transmembrane transport
AL485_RS22340	COG0444	Belongs to the ABC transporter superfamily
AL485_RS22345	COG4608	Belongs to the ABC transporter superfamily
AL485_RS22360	COG1609	Transcriptional regulator
AL485_RS22370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL485_RS22375	COG0395	ABC-type sugar transport system, permease component
AL485_RS22380	COG1175	transmembrane transport
AL485_RS22390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL485_RS22395	COG3138	arginine N-succinyltransferase
AL485_RS22400	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS22405	COG3724	N-succinylarginine dihydrolase activity
AL485_RS22410	COG2988	succinylglutamate desuccinylase activity
AL485_RS22430	COG1652	LysM domain
AL485_RS22445	COG2207	Transcriptional regulator
AL485_RS22485	COG1113	amino acid transport
AL485_RS22510	COG2226	methyltransferase
AL485_RS22515	COG1971	Probably functions as a manganese efflux pump
AL485_RS22520	COG4811	Protein of unknown function (DUF986)
AL485_RS22525	COG3716	PTS system mannose fructose sorbose family IID component
AL485_RS22530	COG3715	PTS system
AL485_RS22535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS22535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL485_RS22540	COG1253	flavin adenine dinucleotide binding
AL485_RS22545	COG2200	EAL domain
AL485_RS22550	COG1760	l-serine dehydratase
AL485_RS22555	COG0494	nUDIX hydrolase
AL485_RS22565	COG1216	Glycosyl transferase, family 2
AL485_RS22570	COG3140	Belongs to the UPF0181 family
AL485_RS22575	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL485_RS22580	COG0513	Belongs to the DEAD box helicase family
AL485_RS22585	COG3141	response to X-ray
AL485_RS22590	COG3097	Belongs to the UPF0267 family
AL485_RS22610	COG2999	glutathione oxidoreductase activity
AL485_RS22620	COG0477	Major facilitator Superfamily
AL485_RS22625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL485_RS22630	COG3132	Protein of unknown function, DUF480
AL485_RS22645	COG0018	arginyl-trna synthetase
AL485_RS22650	COG3102	Protein conserved in bacteria
AL485_RS22655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL485_RS22660	COG3142	Participates in the control of copper homeostasis
AL485_RS22670	COG0500	methyltransferase
AL485_RS22675	COG2226	methyltransferase
AL485_RS22680	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AL485_RS22685	COG1801	Protein of unknown function DUF72
AL485_RS22690	COG1335	isochorismatase
AL485_RS22700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL485_RS22705	COG0494	nUDIX hydrolase
AL485_RS22710	COG0217	transcriptional regulatory protein
AL485_RS22715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL485_RS22720	COG0632	four-way junction helicase activity
AL485_RS22725	COG2255	four-way junction helicase activity
AL485_RS22730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL485_RS22735	COG1121	(ABC) transporter
AL485_RS22740	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL485_RS22745	COG0739	heme binding
AL485_RS22750	COG1560	Kdo2-lipid A biosynthetic process
AL485_RS22760	COG0469	pyruvate kinase activity
AL485_RS22765	COG1737	Transcriptional regulator
AL485_RS22770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL485_RS22775	COG0800	Aldolase
AL485_RS22780	COG2076	Multidrug Resistance protein
AL485_RS22785	COG2076	Multidrug Resistance protein
AL485_RS22790	COG0251	oxidation-reduction process
AL485_RS22795	COG1199	ATP-dependent helicase activity
AL485_RS22805	COG3065	identical protein binding
AL485_RS22810	COG0318	PFAM AMP-dependent synthetase and ligase
AL485_RS22815	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL485_RS22820	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL485_RS22825	COG2894	cell division
AL485_RS22830	COG0850	regulation of cytokinetic process
AL485_RS22835	COG3100	YcgL domain-containing protein
AL485_RS22840	COG2951	lytic endotransglycosylase activity
AL485_RS22845	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL485_RS22855	COG2983	Belongs to the UPF0260 family
AL485_RS22860	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL485_RS22865	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL485_RS22870	COG2186	Transcriptional regulator
AL485_RS22875	COG2719	SpoVR family
AL485_RS22880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL485_RS22885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL485_RS22915	COG0444	Belongs to the ABC transporter superfamily
AL485_RS22930	COG4774	siderophore transport
AL485_RS22965	COG2718	Belongs to the UPF0229 family
AL485_RS22970	COG2766	serine protein kinase
AL485_RS22975	COG3713	MltA-interacting MipA family protein
AL485_RS22985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL485_RS22990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL485_RS22995	COG3139	Protein of unknown function (DUF1315)
AL485_RS23005	COG1335	isochorismatase
AL485_RS23010	COG0252	asparaginase activity
AL485_RS23020	COG0778	Nitroreductase
AL485_RS23030	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AL485_RS23035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL485_RS23045	COG0494	nUDIX hydrolase
AL485_RS23050	COG0708	Exodeoxyribonuclease III
AL485_RS23080	COG0788	formyltetrahydrofolate deformylase activity
AL485_RS23085	COG3012	SEC-C Motif Domain Protein
AL485_RS23090	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL485_RS23095	COG0745	RESPONSE REGULATOR receiver
AL485_RS23100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL485_RS23125	COG1454	alcohol dehydrogenase
AL485_RS23125	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS23130	COG2095	MarC family integral membrane protein
AL485_RS23135	COG4166	transmembrane transport
AL485_RS23150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL485_RS23155	COG0444	Belongs to the ABC transporter superfamily
AL485_RS23180	COG3192	ethanolamine utilization protein
AL485_RS23185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL485_RS23195	COG3099	Belongs to the UPF0263 family
AL485_RS23200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL485_RS23205	COG0783	Belongs to the Dps family
AL485_RS23230	COG0582	viral genome integration into host DNA
AL485_RS23355	COG3179	chitinase
AL485_RS23440	COG0741	lytic transglycosylase activity
AL485_RS23460	COG2350	Protein conserved in bacteria
AL485_RS23465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL485_RS23485	COG1609	Transcriptional regulator
AL485_RS23490	COG1607	acyl-coa hydrolase
AL485_RS23495	COG2917	probably involved in intracellular septation
AL485_RS23510	COG0727	PFAM Uncharacterised protein family (UPF0153)
AL485_RS23515	COG3047	cAMP biosynthetic process
AL485_RS23525	COG0159	tryptophan synthase activity
AL485_RS23530	COG0133	tryptophan synthase activity
AL485_RS23540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL485_RS23555	COG0613	PHP domain protein
AL485_RS23560	COG0009	L-threonylcarbamoyladenylate synthase
AL485_RS23575	COG1187	pseudouridine synthase activity
AL485_RS23580	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL485_RS23585	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS23590	COG0616	signal peptide processing
AL485_RS23605	COG0583	DNA-binding transcription factor activity
AL485_RS23615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL485_RS23625	COG0671	phosphoesterase, PA-phosphatase related
AL485_RS23630	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL485_RS23635	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL485_RS23655	COG0023	Translation Initiation Factor
AL485_RS23665	COG0235	Class ii aldolase
AL485_RS23670	COG1349	DNA-binding transcription factor activity
AL485_RS23675	COG1882	Formate acetyltransferase
AL485_RS23680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL485_RS23685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL485_RS23690	COG1966	Carbon starvation protein
AL485_RS23695	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL485_RS23710	COG0243	molybdopterin cofactor binding
AL485_RS23720	COG0583	DNA-binding transcription factor activity
AL485_RS23725	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL485_RS23725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL485_RS23740	COG4171	peptide transport system, permease
AL485_RS23755	COG1469	GTP cyclohydrolase I activity
AL485_RS23770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL485_RS23775	COG1842	Phage shock protein A
AL485_RS23785	COG1983	PspC domain protein
AL485_RS23795	COG3106	COG3106 Predicted ATPase
AL485_RS23800	COG3768	UPF0283 membrane protein
AL485_RS23810	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL485_RS23815	COG4948	Mandelate Racemase Muconate Lactonizing
AL485_RS23820	COG2866	Carboxypeptidase
AL485_RS23830	COG4166	transmembrane transport
AL485_RS23855	COG0037	tRNA processing
AL485_RS23870	COG0789	Transcriptional regulator
AL485_RS23895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL485_RS23900	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL485_RS23900	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL485_RS23900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL485_RS23900	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL485_RS23910	COG3042	response to heat
AL485_RS23915	COG3187	Heat shock protein
AL485_RS23920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL485_RS23925	COG2911	Protein conserved in bacteria
AL485_RS23935	COG3784	Protein of unknown function (DUF1318)
AL485_RS23940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL485_RS23945	COG1643	Atp-dependent helicase
AL485_RS23950	COG2814	Major facilitator Superfamily
AL485_RS23960	COG3591	Belongs to the peptidase S1B family
AL485_RS23970	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL485_RS23975	COG2205	protein histidine kinase activity
AL485_RS23980	COG0745	RESPONSE REGULATOR receiver
AL485_RS23985	COG1028	Short-chain dehydrogenase reductase Sdr
AL485_RS23995	COG0531	amino acid
AL485_RS24010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL485_RS24015	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL485_RS24020	COG0589	response to stress
AL485_RS24030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL485_RS24045	COG2222	sugar isomerase
AL485_RS24050	COG1349	DNA-binding transcription factor activity
AL485_RS24055	COG1940	carbohydrate kinase activity
AL485_RS24065	COG3842	ATPase activity
AL485_RS24070	COG0395	ABC-type sugar transport system, permease component
AL485_RS24075	COG1175	transmembrane transport
AL485_RS24100	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AL485_RS24125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL485_RS24140	COG0306	phosphate transporter
AL485_RS24200	COG3158	transport of potassium into the cell
AL485_RS24210	COG1309	transcriptional regulator
AL485_RS24240	COG0697	spore germination
AL485_RS24245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL485_RS24270	COG2239	Acts as a magnesium transporter
AL485_RS24290	COG0488	(ABC) transporter
AL485_RS24295	COG1511	domain protein
AL485_RS24295	COG3264	Mechanosensitive ion channel
AL485_RS24305	COG2190	(PTS) system
AL485_RS24305	COG1263	PTS System
AL485_RS24305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL485_RS24310	COG0583	DNA-binding transcription factor activity
AL485_RS24315	COG1653	transport
AL485_RS24335	COG3842	ATPase activity
AL485_RS24340	COG0366	Alpha amylase catalytic
AL485_RS24345	COG2199	diguanylate cyclase activity
AL485_RS24350	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL485_RS24385	COG2723	6-phospho-beta-galactosidase activity
AL485_RS24390	COG1737	Transcriptional regulator
AL485_RS24395	COG2271	Major facilitator Superfamily
AL485_RS24400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL485_RS24405	COG2080	2 iron, 2 sulfur cluster binding
AL485_RS24410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL485_RS24410	COG2010	Cytochrome c
AL485_RS24415	COG2010	Cytochrome c
AL485_RS24415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL485_RS24430	COG1396	sequence-specific DNA binding
AL485_RS24445	COG0583	DNA-binding transcription factor activity
AL485_RS24450	COG2957	Belongs to the agmatine deiminase family
AL485_RS24475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL485_RS24490	COG0693	protein deglycase activity
AL485_RS24495	COG0318	PFAM AMP-dependent synthetase and ligase
AL485_RS24500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL485_RS24505	COG1113	amino acid transport
AL485_RS24515	COG0456	acetyltransferase
AL485_RS24515	COG1846	Transcriptional regulator
AL485_RS24520	COG1012	belongs to the aldehyde dehydrogenase family
AL485_RS24530	COG0583	DNA-binding transcription factor activity
AL485_RS24545	COG2272	Belongs to the type-B carboxylesterase lipase family
AL485_RS24550	COG0583	DNA-binding transcription factor activity
AL485_RS24555	COG2610	gluconate transmembrane transporter activity
AL485_RS24560	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL485_RS24560	COG1902	pentaerythritol trinitrate reductase activity
AL485_RS24565	COG0789	Transcriptional regulator
AL485_RS24595	COG2197	response regulator