locus-tag	class	description
HS042_RS00025	COG1403	HNH endonuclease
HS042_RS00050	COG3772	lysozyme
HS042_RS00085	COG1802	Transcriptional regulator
HS042_RS00085	COG4626	Terminase
HS042_RS00090	COG4695	Portal protein
HS042_RS00200	COG0538	isocitrate dehydrogenase activity
HS042_RS00215	COG3064	Membrane
HS042_RS00250	COG1942	4-Oxalocrotonate Tautomerase
HS042_RS00280	COG1609	Transcriptional regulator
HS042_RS00290	COG0673	inositol 2-dehydrogenase activity
HS042_RS00320	COG0589	response to stress
HS042_RS00325	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS00330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS042_RS00335	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS00340	COG1917	Cupin 2, conserved barrel domain protein
HS042_RS00340	COG1396	sequence-specific DNA binding
HS042_RS00345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HS042_RS00350	COG0174	glutamine synthetase
HS042_RS00355	COG0531	amino acid
HS042_RS00370	COG3248	Nucleoside-binding outer membrane protein
HS042_RS00385	COG1605	Chorismate mutase
HS042_RS00400	COG1228	amidohydrolase
HS042_RS00410	COG0402	S-adenosylhomocysteine deaminase activity
HS042_RS00430	COG2211	Major facilitator Superfamily
HS042_RS00445	COG0477	Major facilitator Superfamily
HS042_RS00450	COG0583	DNA-binding transcription factor activity
HS042_RS00460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HS042_RS00465	COG3493	citrate carrier protein
HS042_RS00530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HS042_RS00530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HS042_RS00535	COG3008	intermembrane lipid transfer
HS042_RS00540	COG2995	paraquat-inducible protein a
HS042_RS00545	COG1956	GAF domain-containing protein
HS042_RS00550	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HS042_RS00555	COG0793	Belongs to the peptidase S41A family
HS042_RS00575	COG1120	ATPase activity
HS042_RS00580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HS042_RS00590	COG0501	Belongs to the peptidase M48B family
HS042_RS00595	COG2814	Major facilitator Superfamily
HS042_RS00625	COG2188	Transcriptional regulator
HS042_RS00640	COG1823	symporter activity
HS042_RS00645	COG1988	membrane-bound metal-dependent
HS042_RS00650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HS042_RS00665	COG3001	Fructosamine kinase
HS042_RS00670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HS042_RS00675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HS042_RS00680	COG1121	(ABC) transporter
HS042_RS00685	COG0803	Belongs to the bacterial solute-binding protein 9 family
HS042_RS00715	COG0814	amino acid
HS042_RS00735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HS042_RS00745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HS042_RS00750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HS042_RS00760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HS042_RS00780	COG4139	cobalamin transport
HS042_RS00785	COG0386	Belongs to the glutathione peroxidase family
HS042_RS00790	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HS042_RS00795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HS042_RS00800	COG1215	transferase activity, transferring glycosyl groups
HS042_RS00805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HS042_RS00805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HS042_RS00810	COG0726	polysaccharide deacetylase
HS042_RS00815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HS042_RS00820	COG2076	Multidrug Resistance protein
HS042_RS00825	COG2076	Multidrug Resistance protein
HS042_RS00830	COG0791	NLP P60 protein
HS042_RS00835	COG0095	Lipoate-protein ligase
HS042_RS00855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HS042_RS00860	COG4558	Periplasmic binding protein
HS042_RS00865	COG3720	iron ion transport
HS042_RS00880	COG0386	Belongs to the glutathione peroxidase family
HS042_RS00885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HS042_RS00890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HS042_RS00895	COG0574	Belongs to the PEP-utilizing enzyme family
HS042_RS00895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HS042_RS00905	COG0628	permease
HS042_RS00910	COG0247	lactate metabolic process
HS042_RS00910	COG0277	FAD linked oxidase domain protein
HS042_RS00915	COG2050	protein possibly involved in aromatic compounds catabolism
HS042_RS00925	COG0316	Belongs to the HesB IscA family
HS042_RS00930	COG0719	Fe-S assembly protein
HS042_RS00935	COG0396	ATPase activity
HS042_RS00940	COG0719	Fe-S assembly protein
HS042_RS00945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HS042_RS00950	COG2166	iron-sulfur cluster assembly
HS042_RS00955	COG1388	LysM domain
HS042_RS00955	COG1376	ErfK ybiS ycfS ynhG family protein
HS042_RS00965	COG0469	pyruvate kinase activity
HS042_RS00990	COG0534	Mate efflux family protein
HS042_RS00995	COG0307	riboflavin synthase, alpha
HS042_RS01005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HS042_RS01010	COG2814	Major facilitator Superfamily
HS042_RS01015	COG0583	DNA-binding transcription factor activity
HS042_RS01020	COG1609	Transcriptional regulator
HS042_RS01035	COG0791	NLP P60 protein
HS042_RS01040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HS042_RS01050	COG0346	lactoylglutathione lyase activity
HS042_RS01055	COG1902	pentaerythritol trinitrate reductase activity
HS042_RS01060	COG1309	transcriptional regulator
HS042_RS01065	COG2194	sulfuric ester hydrolase activity
HS042_RS01075	COG0583	DNA-binding transcription factor activity
HS042_RS01080	COG3313	Fe-S protein
HS042_RS01085	COG4989	oxidoreductase activity
HS042_RS01090	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HS042_RS01100	COG1289	transmembrane transporter activity
HS042_RS01105	COG1566	PFAM secretion protein HlyD family protein
HS042_RS01115	COG1846	Transcriptional regulator
HS042_RS01120	COG3133	Outer membrane lipoprotein
HS042_RS01125	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HS042_RS01135	COG0259	pyridoxamine-phosphate oxidase activity
HS042_RS01140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HS042_RS01150	COG0625	glutathione transferase activity
HS042_RS01165	COG1418	mRNA catabolic process
HS042_RS01200	COG3135	benzoate transporter
HS042_RS01205	COG1396	sequence-specific DNA binding
HS042_RS01210	COG1505	serine-type exopeptidase activity
HS042_RS01215	COG3104	oligopeptide transport
HS042_RS01220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HS042_RS01230	COG4659	FMN binding
HS042_RS01240	COG2207	Transcriptional regulator
HS042_RS01240	COG3708	Transcriptional regulator
HS042_RS01245	COG4656	Part of a membrane complex involved in electron transport
HS042_RS01250	COG2878	Part of a membrane complex involved in electron transport
HS042_RS01255	COG4657	Part of a membrane complex involved in electron transport
HS042_RS01265	COG0673	inositol 2-dehydrogenase activity
HS042_RS01270	COG0385	Bile acid
HS042_RS01280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HS042_RS01285	COG1349	DNA-binding transcription factor activity
HS042_RS01290	COG0494	nUDIX hydrolase
HS042_RS01300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HS042_RS01305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS01305	COG1263	PTS System
HS042_RS01310	COG1609	Transcriptional regulator
HS042_RS01325	COG0583	DNA-binding transcription factor activity
HS042_RS01335	COG5339	Protein conserved in bacteria
HS042_RS01350	COG0114	fumarate hydratase activity
HS042_RS01365	COG2378	regulation of single-species biofilm formation
HS042_RS01380	COG1472	Belongs to the glycosyl hydrolase 3 family
HS042_RS01385	COG1649	PFAM Uncharacterised BCR, COG1649
HS042_RS01390	COG2814	Major facilitator Superfamily
HS042_RS01395	COG0583	DNA-binding transcription factor activity
HS042_RS01400	COG1940	carbohydrate kinase activity
HS042_RS01405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HS042_RS01415	COG0789	Transcriptional regulator
HS042_RS01445	COG0477	Major facilitator Superfamily
HS042_RS01460	COG1742	UPF0060 membrane protein
HS042_RS01465	COG4221	oxidoreductase activity
HS042_RS01475	COG4772	TonB-dependent receptor
HS042_RS01480	COG3712	iron ion homeostasis
HS042_RS01485	COG1595	DNA-templated transcription, initiation
HS042_RS01490	COG0402	S-adenosylhomocysteine deaminase activity
HS042_RS01500	COG0339	signal peptide processing
HS042_RS01505	COG2271	Major facilitator Superfamily
HS042_RS01510	COG1335	isochorismatase
HS042_RS01515	COG3473	Maleate cis-trans isomerase
HS042_RS01520	COG0596	Alpha beta hydrolase
HS042_RS01525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HS042_RS01530	COG2309	aminopeptidase activity
HS042_RS01535	COG1846	Transcriptional regulator
HS042_RS01540	COG2080	2 iron, 2 sulfur cluster binding
HS042_RS01545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HS042_RS01545	COG2010	Cytochrome c
HS042_RS01600	COG2140	Oxalate decarboxylase
HS042_RS01635	COG0596	Alpha beta hydrolase
HS042_RS01685	COG2169	Transcriptional regulator
HS042_RS01685	COG1917	Cupin 2, conserved barrel domain protein
HS042_RS01705	COG2814	Major facilitator Superfamily
HS042_RS01710	COG1335	isochorismatase
HS042_RS01735	COG0768	penicillin binding
HS042_RS01750	COG0840	transmembrane signaling receptor activity
HS042_RS01775	COG0583	DNA-binding transcription factor activity
HS042_RS01785	COG2814	Major facilitator Superfamily
HS042_RS01795	COG1349	DNA-binding transcription factor activity
HS042_RS01800	COG0673	inositol 2-dehydrogenase activity
HS042_RS01805	COG0477	Major facilitator Superfamily
HS042_RS01810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HS042_RS01830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HS042_RS01835	COG2862	Uncharacterized protein family, UPF0114
HS042_RS01840	COG2814	Major facilitator Superfamily
HS042_RS01845	COG0583	DNA-binding transcription factor activity
HS042_RS01855	COG0446	pyridine nucleotide-disulphide oxidoreductase
HS042_RS01870	COG1064	alcohol dehydrogenase
HS042_RS01880	COG3284	Transcriptional regulator
HS042_RS01890	COG2814	Major facilitator Superfamily
HS042_RS01900	COG2223	nitrite transmembrane transporter activity
HS042_RS01910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HS042_RS01925	COG5001	Diguanylate cyclase
HS042_RS01925	COG3300	MHYT domain
HS042_RS01965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HS042_RS01980	COG0583	DNA-binding transcription factor activity
HS042_RS01985	COG0076	glutamate decarboxylase activity
HS042_RS01990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HS042_RS01995	COG1902	pentaerythritol trinitrate reductase activity
HS042_RS01995	COG0446	pyridine nucleotide-disulphide oxidoreductase
HS042_RS02000	COG0789	Transcriptional regulator
HS042_RS02005	COG0148	phosphopyruvate hydratase activity
HS042_RS02015	COG1227	inorganic diphosphatase activity
HS042_RS02020	COG5001	Diguanylate cyclase
HS042_RS02020	COG3447	MASE1 domain protein
HS042_RS02020	COG5002	protein histidine kinase activity
HS042_RS02035	COG0583	DNA-binding transcription factor activity
HS042_RS02060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HS042_RS02070	COG1063	alcohol dehydrogenase
HS042_RS02100	COG1082	Xylose isomerase domain protein TIM barrel
HS042_RS02105	COG0673	inositol 2-dehydrogenase activity
HS042_RS02145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HS042_RS02185	COG2249	NAD(P)H dehydrogenase (quinone) activity
HS042_RS02190	COG1280	lysine exporter protein (LysE YggA)
HS042_RS02215	COG0477	Major facilitator Superfamily
HS042_RS02230	COG2382	esterase
HS042_RS02235	COG4774	siderophore transport
HS042_RS02245	COG1113	amino acid transport
HS042_RS02250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HS042_RS02255	COG0318	PFAM AMP-dependent synthetase and ligase
HS042_RS02260	COG0693	protein deglycase activity
HS042_RS02275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HS042_RS02305	COG2957	Belongs to the agmatine deiminase family
HS042_RS02310	COG0583	DNA-binding transcription factor activity
HS042_RS02320	COG0243	molybdopterin cofactor binding
HS042_RS02340	COG0778	Nitroreductase
HS042_RS02345	COG2010	Cytochrome c
HS042_RS02345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HS042_RS02350	COG2010	Cytochrome c
HS042_RS02350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HS042_RS02355	COG2080	2 iron, 2 sulfur cluster binding
HS042_RS02370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HS042_RS02375	COG1737	Transcriptional regulator
HS042_RS02380	COG2723	6-phospho-beta-galactosidase activity
HS042_RS02385	COG3048	D-serine ammonia-lyase activity
HS042_RS02400	COG5507	3-demethylubiquinone-9 3-methyltransferase
HS042_RS02405	COG2199	diguanylate cyclase activity
HS042_RS02425	COG1196	nuclear chromosome segregation
HS042_RS02425	COG3264	Mechanosensitive ion channel
HS042_RS02430	COG0488	(ABC) transporter
HS042_RS02435	COG0483	inositol monophosphate 1-phosphatase activity
HS042_RS02440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HS042_RS02455	COG2239	Acts as a magnesium transporter
HS042_RS02490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HS042_RS02495	COG0697	spore germination
HS042_RS02535	COG0363	glucosamine-6-phosphate deaminase activity
HS042_RS02540	COG3158	transport of potassium into the cell
HS042_RS02620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HS042_RS02640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HS042_RS02645	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HS042_RS02670	COG1175	transmembrane transport
HS042_RS02675	COG0395	ABC-type sugar transport system, permease component
HS042_RS02680	COG3842	ATPase activity
HS042_RS02685	COG0673	inositol 2-dehydrogenase activity
HS042_RS02690	COG1940	carbohydrate kinase activity
HS042_RS02695	COG1349	DNA-binding transcription factor activity
HS042_RS02700	COG2222	sugar isomerase
HS042_RS02715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HS042_RS02725	COG0589	response to stress
HS042_RS02730	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HS042_RS02735	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HS042_RS02750	COG0531	amino acid
HS042_RS02775	COG0745	RESPONSE REGULATOR receiver
HS042_RS02780	COG2205	protein histidine kinase activity
HS042_RS02785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HS042_RS02790	COG2267	carboxylic ester hydrolase activity
HS042_RS02800	COG3591	Belongs to the peptidase S1B family
HS042_RS02810	COG2814	Major facilitator Superfamily
HS042_RS02815	COG1643	Atp-dependent helicase
HS042_RS02820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HS042_RS02825	COG3784	Protein of unknown function (DUF1318)
HS042_RS02835	COG2911	Protein conserved in bacteria
HS042_RS02840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS042_RS02845	COG3187	Heat shock protein
HS042_RS02850	COG3042	response to heat
HS042_RS02860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS042_RS02860	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS042_RS02860	COG0674	pyruvate-flavodoxin oxidoreductase activity
HS042_RS02860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HS042_RS02865	COG0037	tRNA processing
HS042_RS02895	COG4166	transmembrane transport
HS042_RS02905	COG2866	Carboxypeptidase
HS042_RS02910	COG4948	Mandelate Racemase Muconate Lactonizing
HS042_RS02915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HS042_RS02925	COG3768	UPF0283 membrane protein
HS042_RS02930	COG3106	COG3106 Predicted ATPase
HS042_RS02940	COG1983	PspC domain protein
HS042_RS02950	COG1842	Phage shock protein A
HS042_RS02955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HS042_RS02970	COG1469	GTP cyclohydrolase I activity
HS042_RS02985	COG4171	peptide transport system, permease
HS042_RS02990	COG4172	Belongs to the ABC transporter superfamily
HS042_RS02995	COG4172	Belongs to the ABC transporter superfamily
HS042_RS03000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HS042_RS03000	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HS042_RS03005	COG0583	DNA-binding transcription factor activity
HS042_RS03015	COG0243	molybdopterin cofactor binding
HS042_RS03030	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HS042_RS03035	COG0477	Major facilitator Superfamily
HS042_RS03040	COG1473	amidohydrolase
HS042_RS03050	COG1966	Carbon starvation protein
HS042_RS03055	COG0859	PFAM glycosyl transferase family 9
HS042_RS03085	COG2831	hemolysin activation secretion protein
HS042_RS03090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HS042_RS03095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HS042_RS03100	COG1882	Formate acetyltransferase
HS042_RS03105	COG1349	DNA-binding transcription factor activity
HS042_RS03115	COG0023	Translation Initiation Factor
HS042_RS03120	COG0284	orotidine-5'-phosphate decarboxylase activity
HS042_RS03135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HS042_RS03140	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HS042_RS03145	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS03150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HS042_RS03155	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS03160	COG1129	ABC transporter
HS042_RS03175	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS03180	COG3958	Transketolase
HS042_RS03185	COG3959	Transketolase, thiamine diphosphate binding domain
HS042_RS03190	COG1349	DNA-binding transcription factor activity
HS042_RS03195	COG0671	phosphoesterase, PA-phosphatase related
HS042_RS03205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HS042_RS03210	COG0583	DNA-binding transcription factor activity
HS042_RS03225	COG0616	signal peptide processing
HS042_RS03230	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS03235	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HS042_RS03240	COG1187	pseudouridine synthase activity
HS042_RS03255	COG0009	L-threonylcarbamoyladenylate synthase
HS042_RS03260	COG0613	PHP domain protein
HS042_RS03275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HS042_RS03285	COG0133	tryptophan synthase activity
HS042_RS03290	COG0159	tryptophan synthase activity
HS042_RS03305	COG0727	PFAM Uncharacterised protein family (UPF0153)
HS042_RS03320	COG2917	probably involved in intracellular septation
HS042_RS03325	COG1607	acyl-coa hydrolase
HS042_RS03335	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HS042_RS03340	COG2350	Protein conserved in bacteria
HS042_RS03360	COG0583	DNA-binding transcription factor activity
HS042_RS03370	COG1609	Transcriptional regulator
HS042_RS03385	COG1070	Carbohydrate kinase
HS042_RS03390	COG1129	ABC transporter
HS042_RS03395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS03400	COG1879	ABC-type sugar transport system periplasmic component
HS042_RS03415	COG0783	Belongs to the Dps family
HS042_RS03425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HS042_RS03430	COG3099	Belongs to the UPF0263 family
HS042_RS03440	COG0444	Belongs to the ABC transporter superfamily
HS042_RS03445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HS042_RS03460	COG4166	transmembrane transport
HS042_RS03465	COG2095	MarC family integral membrane protein
HS042_RS03470	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS03470	COG1454	alcohol dehydrogenase
HS042_RS03495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HS042_RS03500	COG0745	RESPONSE REGULATOR receiver
HS042_RS03505	COG1752	Esterase of the alpha-beta hydrolase superfamily
HS042_RS03510	COG3012	SEC-C Motif Domain Protein
HS042_RS03515	COG0788	formyltetrahydrofolate deformylase activity
HS042_RS03545	COG0708	Exodeoxyribonuclease III
HS042_RS03550	COG0494	nUDIX hydrolase
HS042_RS03560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HS042_RS03565	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HS042_RS03575	COG0778	Nitroreductase
HS042_RS03580	COG0616	signal peptide processing
HS042_RS03585	COG0252	asparaginase activity
HS042_RS03590	COG1335	isochorismatase
HS042_RS03600	COG3139	Protein of unknown function (DUF1315)
HS042_RS03605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HS042_RS03620	COG3713	MltA-interacting MipA family protein
HS042_RS03625	COG2766	serine protein kinase
HS042_RS03630	COG2718	Belongs to the UPF0229 family
HS042_RS03670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HS042_RS03675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS042_RS03685	COG3443	Belongs to the bacterial solute-binding protein 9 family
HS042_RS03690	COG2719	SpoVR family
HS042_RS03700	COG2186	Transcriptional regulator
HS042_RS03705	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HS042_RS03710	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HS042_RS03720	COG2983	Belongs to the UPF0260 family
HS042_RS03725	COG0179	Fumarylacetoacetate (FAA) hydrolase
HS042_RS03730	COG2951	lytic endotransglycosylase activity
HS042_RS03735	COG3100	YcgL domain-containing protein
HS042_RS03740	COG0850	regulation of cytokinetic process
HS042_RS03745	COG2894	cell division
HS042_RS03750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HS042_RS03755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HS042_RS03760	COG0318	PFAM AMP-dependent synthetase and ligase
HS042_RS03765	COG3065	identical protein binding
HS042_RS03775	COG1199	ATP-dependent helicase activity
HS042_RS03780	COG0251	oxidation-reduction process
HS042_RS03785	COG2076	Multidrug Resistance protein
HS042_RS03790	COG2076	Multidrug Resistance protein
HS042_RS03795	COG0800	Aldolase
HS042_RS03800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HS042_RS03805	COG1737	Transcriptional regulator
HS042_RS03820	COG1560	Kdo2-lipid A biosynthetic process
HS042_RS03825	COG0739	heme binding
HS042_RS03830	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HS042_RS03835	COG1121	(ABC) transporter
HS042_RS03840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HS042_RS03845	COG2255	four-way junction helicase activity
HS042_RS03850	COG0632	four-way junction helicase activity
HS042_RS03855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HS042_RS03860	COG0217	transcriptional regulatory protein
HS042_RS03865	COG0494	nUDIX hydrolase
HS042_RS03870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HS042_RS03880	COG1335	isochorismatase
HS042_RS03885	COG1801	Protein of unknown function DUF72
HS042_RS03890	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HS042_RS03895	COG2226	methyltransferase
HS042_RS03900	COG0500	methyltransferase
HS042_RS03905	COG0545	Peptidyl-prolyl cis-trans isomerase
HS042_RS03920	COG3142	Participates in the control of copper homeostasis
HS042_RS03925	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HS042_RS03930	COG3102	Protein conserved in bacteria
HS042_RS03935	COG0018	arginyl-trna synthetase
HS042_RS03945	COG0673	inositol 2-dehydrogenase activity
HS042_RS03950	COG3132	Protein of unknown function, DUF480
HS042_RS03955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HS042_RS03960	COG0477	Major facilitator Superfamily
HS042_RS03970	COG2999	glutathione oxidoreductase activity
HS042_RS03990	COG3097	Belongs to the UPF0267 family
HS042_RS03995	COG3141	response to X-ray
HS042_RS04000	COG0513	Belongs to the DEAD box helicase family
HS042_RS04010	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HS042_RS04015	COG3140	Belongs to the UPF0181 family
HS042_RS04020	COG1216	Glycosyl transferase, family 2
HS042_RS04030	COG0494	nUDIX hydrolase
HS042_RS04035	COG1760	l-serine dehydratase
HS042_RS04040	COG2200	EAL domain
HS042_RS04045	COG1253	flavin adenine dinucleotide binding
HS042_RS04050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS042_RS04050	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS04055	COG3715	PTS system
HS042_RS04060	COG3716	PTS system mannose fructose sorbose family IID component
HS042_RS04065	COG4811	Protein of unknown function (DUF986)
HS042_RS04070	COG1971	Probably functions as a manganese efflux pump
HS042_RS04075	COG2226	methyltransferase
HS042_RS04080	COG1496	oxidoreductase activity
HS042_RS04110	COG1113	amino acid transport
HS042_RS04155	COG2207	Transcriptional regulator
HS042_RS04180	COG1652	LysM domain
HS042_RS04200	COG2988	succinylglutamate desuccinylase activity
HS042_RS04205	COG3724	N-succinylarginine dihydrolase activity
HS042_RS04210	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS04215	COG3138	arginine N-succinyltransferase
HS042_RS04220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HS042_RS04230	COG4608	Belongs to the ABC transporter superfamily
HS042_RS04235	COG0444	Belongs to the ABC transporter superfamily
HS042_RS04245	COG0601	transmembrane transport
HS042_RS04255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HS042_RS04260	COG1271	oxidase subunit
HS042_RS04265	COG1294	oxidase, subunit
HS042_RS04315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HS042_RS04320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HS042_RS04325	COG2181	nitrate reductase activity
HS042_RS04330	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HS042_RS04335	COG1140	nitrate reductase beta subunit
HS042_RS04340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HS042_RS04390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HS042_RS04395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HS042_RS04400	COG3710	Transcriptional regulator
HS042_RS04405	COG2223	nitrite transmembrane transporter activity
HS042_RS04410	COG3850	Histidine kinase
HS042_RS04415	COG2197	response regulator
HS042_RS04420	COG4932	domain protein
HS042_RS04425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HS042_RS04435	COG0747	negative chemotaxis
HS042_RS04440	COG4608	Belongs to the ABC transporter superfamily
HS042_RS04445	COG0444	Belongs to the ABC transporter superfamily
HS042_RS04450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HS042_RS04455	COG0601	transmembrane transport
HS042_RS04475	COG0583	DNA-binding transcription factor activity
HS042_RS04480	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HS042_RS04485	COG4572	Cation transport regulator
HS042_RS04490	COG2375	cellular response to nickel ion
HS042_RS04495	COG0387	Pfam Sodium calcium exchanger
HS042_RS04505	COG1702	phosphate starvation-inducible protein PhoH
HS042_RS04515	COG2822	iron ion transport
HS042_RS04520	COG0672	)-iron permease
HS042_RS04530	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HS042_RS04530	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HS042_RS04530	COG0506	proline dehydrogenase activity
HS042_RS04545	COG1126	abc transporter atp-binding protein
HS042_RS04550	COG0765	amino acid transport
HS042_RS04555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS04560	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HS042_RS04570	COG1191	sigma factor activity
HS042_RS04580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HS042_RS04600	COG0583	DNA-binding transcription factor activity
HS042_RS04610	COG1677	Flagellar hook-basal body complex protein FliE
HS042_RS04620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HS042_RS04625	COG1317	bacterial-type flagellum organization
HS042_RS04630	COG1157	protein secretion by the type III secretion system
HS042_RS04635	COG2882	bacterial-type flagellum organization
HS042_RS04640	COG3144	bacterial-type flagellum assembly
HS042_RS04700	COG1256	bacterial-type flagellum assembly
HS042_RS04735	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HS042_RS04740	COG1558	bacterial-type flagellum-dependent cell motility
HS042_RS04745	COG1815	bacterial-type flagellum-dependent cell motility
HS042_RS04755	COG2747	anti-sigma28 factor FlgM
HS042_RS04760	COG3418	PFAM FlgN family protein
HS042_RS04780	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HS042_RS04785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HS042_RS04790	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HS042_RS04795	COG0745	RESPONSE REGULATOR receiver
HS042_RS04805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HS042_RS04810	COG0840	transmembrane signaling receptor activity
HS042_RS04815	COG0840	transmembrane signaling receptor activity
HS042_RS04820	COG0835	chemotaxis
HS042_RS04825	COG0643	Histidine kinase
HS042_RS04825	COG2198	Histidine kinase
HS042_RS04855	COG0589	response to stress
HS042_RS04860	COG2130	NADP-dependent
HS042_RS04865	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HS042_RS05035	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HS042_RS05040	COG3483	tryptophan 2,3-dioxygenase activity
HS042_RS05045	COG1609	Transcriptional regulator
HS042_RS05085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HS042_RS05090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HS042_RS05100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HS042_RS05120	COG3781	membrane
HS042_RS05125	COG2837	iron assimilation
HS042_RS05130	COG1414	Transcriptional regulator
HS042_RS05140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HS042_RS05145	COG0183	Belongs to the thiolase family
HS042_RS05150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HS042_RS05155	COG4948	Mandelate Racemase Muconate Lactonizing
HS042_RS05165	COG3485	protocatechuate 3,4-dioxygenase
HS042_RS05175	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HS042_RS05190	COG1393	Belongs to the ArsC family
HS042_RS05195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HS042_RS05205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HS042_RS05230	COG1285	pathogenesis
HS042_RS05240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HS042_RS05250	COG0076	glutamate decarboxylase activity
HS042_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS05285	COG3321	synthase
HS042_RS05285	COG0604	alcohol dehydrogenase
HS042_RS05295	COG0583	DNA-binding transcription factor activity
HS042_RS05300	COG3753	Protein conserved in bacteria
HS042_RS05305	COG2261	transglycosylase associated protein
HS042_RS05315	COG1560	Kdo2-lipid A biosynthetic process
HS042_RS05320	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HS042_RS05330	COG3706	GGDEF domain
HS042_RS05330	COG2203	Gaf domain
HS042_RS05330	COG5001	Diguanylate cyclase
HS042_RS05330	COG4251	negative regulation of phosphorylation
HS042_RS05340	COG2030	dehydratase
HS042_RS05340	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS05345	COG3396	Phenylacetate-CoA oxygenase
HS042_RS05350	COG3460	Phenylacetate-CoA oxygenase
HS042_RS05355	COG3396	Phenylacetate-CoA oxygenase
HS042_RS05360	COG2151	metal-sulfur cluster biosynthetic enzyme
HS042_RS05365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HS042_RS05370	COG1024	Enoyl-CoA hydratase
HS042_RS05375	COG1024	Enoyl-CoA hydratase
HS042_RS05380	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS042_RS05385	COG2050	protein possibly involved in aromatic compounds catabolism
HS042_RS05390	COG0183	Belongs to the thiolase family
HS042_RS05395	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HS042_RS05400	COG3327	negative regulation of DNA-templated transcription, initiation
HS042_RS05405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HS042_RS05410	COG1113	amino acid transport
HS042_RS05430	COG0583	DNA-binding transcription factor activity
HS042_RS05435	COG0625	glutathione transferase activity
HS042_RS05475	COG0667	Aldo Keto reductase
HS042_RS05480	COG4772	TonB-dependent receptor
HS042_RS05485	COG4993	Dehydrogenase
HS042_RS05500	COG0534	Mate efflux family protein
HS042_RS05570	COG0561	phosphatase activity
HS042_RS05585	COG2197	response regulator
HS042_RS05720	COG3228	Belongs to the MtfA family
HS042_RS05730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HS042_RS05735	COG4977	sequence-specific DNA binding
HS042_RS05745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HS042_RS05750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HS042_RS05755	COG1116	anion transmembrane transporter activity
HS042_RS05760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HS042_RS05765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HS042_RS05780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HS042_RS05800	COG3238	Protein conserved in bacteria
HS042_RS05805	COG1247	-acetyltransferase
HS042_RS05825	COG0583	DNA-binding transcription factor activity
HS042_RS05840	COG2814	Major facilitator Superfamily
HS042_RS05850	COG2011	ABC-type metal ion transport system permease component
HS042_RS05870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HS042_RS05890	COG4172	Belongs to the ABC transporter superfamily
HS042_RS05895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HS042_RS05905	COG0747	negative chemotaxis
HS042_RS05915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HS042_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS05940	COG1169	isochorismate synthase
HS042_RS05955	COG0471	metal ion transport
HS042_RS05960	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HS042_RS05970	COG3051	citrate lyase alpha subunit
HS042_RS05975	COG2301	Belongs to the HpcH HpaI aldolase family
HS042_RS05980	COG3052	prosthetic group binding
HS042_RS05985	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HS042_RS05990	COG4565	transcriptional regulatory protein
HS042_RS05995	COG3250	beta-galactosidase activity
HS042_RS06005	COG0300	oxidoreductase activity
HS042_RS06010	COG2207	Transcriptional regulator
HS042_RS06015	COG0667	Aldo Keto reductase
HS042_RS06050	COG0582	viral genome integration into host DNA
HS042_RS06055	COG4581	dead DEAH box helicase
HS042_RS06085	COG0583	DNA-binding transcription factor activity
HS042_RS06090	COG2197	response regulator
HS042_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS06110	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HS042_RS06145	COG2070	2-Nitropropane dioxygenase
HS042_RS06165	COG2271	Major facilitator Superfamily
HS042_RS06195	COG0411	ABC transporter
HS042_RS06235	COG4221	oxidoreductase activity
HS042_RS06240	COG0702	epimerase
HS042_RS06245	COG1073	alpha beta
HS042_RS06250	COG1073	alpha beta
HS042_RS06255	COG0583	DNA-binding transcription factor activity
HS042_RS06280	COG0583	DNA-binding transcription factor activity
HS042_RS06290	COG0456	acetyltransferase
HS042_RS06305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HS042_RS06310	COG0156	8-amino-7-oxononanoate synthase activity
HS042_RS06315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS042_RS06320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS042_RS06325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS042_RS06330	COG2244	polysaccharide biosynthetic process
HS042_RS06340	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HS042_RS06345	COG0795	lipopolysaccharide-transporting ATPase activity
HS042_RS06355	COG0463	Glycosyl transferase, family 2
HS042_RS06375	COG0583	DNA-binding transcription factor activity
HS042_RS06390	COG1609	Transcriptional regulator
HS042_RS06400	COG3623	hexulose-6-phosphate isomerase
HS042_RS06405	COG1070	Carbohydrate kinase
HS042_RS06410	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS06415	COG1129	ABC transporter
HS042_RS06420	COG1879	ABC-type sugar transport system periplasmic component
HS042_RS06425	COG1063	alcohol dehydrogenase
HS042_RS06435	COG1473	amidohydrolase
HS042_RS06440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS06445	COG2926	Belongs to the UPF0265 family
HS042_RS06450	COG1289	transmembrane transporter activity
HS042_RS06455	COG3023	N-Acetylmuramoyl-L-alanine amidase
HS042_RS06480	COG2925	Exonuclease
HS042_RS06485	COG0531	amino acid
HS042_RS06490	COG0174	glutamine synthetase
HS042_RS06495	COG1917	Cupin 2, conserved barrel domain protein
HS042_RS06495	COG1396	sequence-specific DNA binding
HS042_RS06500	COG1129	ABC transporter
HS042_RS06505	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS06510	COG4771	TonB-dependent receptor
HS042_RS06525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HS042_RS06535	COG0833	amino acid
HS042_RS06540	COG0583	DNA-binding transcription factor activity
HS042_RS06550	COG2855	membrane
HS042_RS06555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HS042_RS06560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HS042_RS06560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HS042_RS06560	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HS042_RS06565	COG1105	Belongs to the carbohydrate kinase PfkB family
HS042_RS06575	COG0494	nUDIX hydrolase
HS042_RS06580	COG3005	denitrification pathway
HS042_RS06585	COG0243	molybdopterin cofactor binding
HS042_RS06600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HS042_RS06605	COG1312	Catalyzes the dehydration of D-mannonate
HS042_RS06610	COG0246	Mannitol dehydrogenase
HS042_RS06620	COG0523	cobalamin synthesis protein
HS042_RS06625	COG0671	phosphoesterase, PA-phosphatase related
HS042_RS06630	COG0791	NLP P60 protein
HS042_RS06635	COG2200	EAL domain
HS042_RS06640	COG4166	transmembrane transport
HS042_RS06645	COG4174	ABC transporter (Permease)
HS042_RS06650	COG4239	(ABC) transporter, permease
HS042_RS06655	COG4172	Belongs to the ABC transporter superfamily
HS042_RS06665	COG2814	Major facilitator Superfamily
HS042_RS06670	COG1187	pseudouridine synthase activity
HS042_RS06675	COG1061	Type III restriction enzyme res subunit
HS042_RS06680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HS042_RS06685	COG3081	Nucleoid-associated protein
HS042_RS06690	COG3082	Protein of unknown function (DUF1414)
HS042_RS06695	COG3083	sulfuric ester hydrolase activity
HS042_RS06795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS042_RS06820	COG0346	lactoylglutathione lyase activity
HS042_RS06835	COG2223	nitrite transmembrane transporter activity
HS042_RS06840	COG0642	Histidine kinase
HS042_RS06840	COG2198	Histidine kinase
HS042_RS06845	COG2197	response regulator
HS042_RS06850	COG2205	protein histidine kinase activity
HS042_RS06850	COG0784	Response regulator, receiver
HS042_RS06860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HS042_RS06865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HS042_RS06875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HS042_RS06900	COG0814	amino acid
HS042_RS06915	COG0318	PFAM AMP-dependent synthetase and ligase
HS042_RS06925	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HS042_RS06930	COG0596	Alpha beta hydrolase
HS042_RS06935	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HS042_RS06940	COG4575	ribosome binding
HS042_RS06945	COG1063	alcohol dehydrogenase
HS042_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS06980	COG0028	Belongs to the TPP enzyme family
HS042_RS06985	COG0583	DNA-binding transcription factor activity
HS042_RS06990	COG1007	ATP synthesis coupled electron transport
HS042_RS06995	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS042_RS07000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HS042_RS07005	COG0713	ATP synthesis coupled electron transport
HS042_RS07010	COG0839	Belongs to the complex I subunit 6 family
HS042_RS07020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HS042_RS07025	COG1034	ATP synthesis coupled electron transport
HS042_RS07040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS042_RS07040	COG0649	NAD binding
HS042_RS07045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS042_RS07050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS042_RS07055	COG0583	DNA-binding transcription factor activity
HS042_RS07060	COG0436	Aminotransferase
HS042_RS07065	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HS042_RS07070	COG0471	metal ion transport
HS042_RS07070	COG0490	domain, Protein
HS042_RS07075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HS042_RS07080	COG3013	Belongs to the UPF0304 family
HS042_RS07085	COG3092	negative regulation of chromosome organization
HS042_RS07090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HS042_RS07095	COG0280	phosphate acetyltransferase
HS042_RS07095	COG0857	belongs to the CobB CobQ family
HS042_RS07100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HS042_RS07105	COG3959	Transketolase, thiamine diphosphate binding domain
HS042_RS07110	COG3037	sugar-specific permease SgaT UlaA
HS042_RS07120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS042_RS07125	COG1609	Transcriptional regulator
HS042_RS07130	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HS042_RS07135	COG0622	Phosphoesterase
HS042_RS07140	COG0625	glutathione transferase activity
HS042_RS07145	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HS042_RS07150	COG1090	epimerase
HS042_RS07155	COG4598	ABC transporter
HS042_RS07165	COG4215	(ABC) transporter
HS042_RS07170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS07175	COG0163	prenyltransferase activity
HS042_RS07180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HS042_RS07185	COG1286	toxin biosynthetic process
HS042_RS07190	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HS042_RS07195	COG0285	dihydrofolate synthase activity
HS042_RS07200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HS042_RS07205	COG0586	Pfam SNARE associated Golgi protein
HS042_RS07215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HS042_RS07220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HS042_RS07230	COG0697	spore germination
HS042_RS07235	COG0642	Histidine kinase
HS042_RS07275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HS042_RS07280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HS042_RS07320	COG2195	Cleaves the N-terminal amino acid of tripeptides
HS042_RS07325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HS042_RS07340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HS042_RS07345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS042_RS07345	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HS042_RS07355	COG3101	peptidyl-lysine hydroxylation
HS042_RS07360	COG0730	response to heat
HS042_RS07365	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HS042_RS07370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HS042_RS07375	COG2890	protein-(glutamine-N5) methyltransferase activity
HS042_RS07380	COG2840	Smr protein MutS2
HS042_RS07385	COG2062	phosphohistidine phosphatase, SixA
HS042_RS07390	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS042_RS07390	COG1024	Enoyl-CoA hydratase
HS042_RS07395	COG0183	Belongs to the thiolase family
HS042_RS07400	COG3691	Protein conserved in bacteria
HS042_RS07415	COG3088	subunit of a heme lyase
HS042_RS07415	COG4235	cytochrome complex assembly
HS042_RS07420	COG3088	subunit of a heme lyase
HS042_RS07420	COG4235	cytochrome complex assembly
HS042_RS07425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HS042_RS07430	COG1138	Cytochrome C-type biogenesis protein
HS042_RS07435	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HS042_RS07440	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HS042_RS07445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HS042_RS07450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HS042_RS07460	COG2116	formate transmembrane transporter activity
HS042_RS07470	COG2706	6-phosphogluconolactonase activity
HS042_RS07475	COG3708	Transcriptional regulator
HS042_RS07475	COG2207	Transcriptional regulator
HS042_RS07490	COG2197	response regulator
HS042_RS07500	COG0583	DNA-binding transcription factor activity
HS042_RS07510	COG0697	spore germination
HS042_RS07525	COG2951	lytic endotransglycosylase activity
HS042_RS07540	COG1215	transferase activity, transferring glycosyl groups
HS042_RS07545	COG1649	PFAM Uncharacterised BCR, COG1649
HS042_RS07545	COG0726	polysaccharide deacetylase
HS042_RS07550	COG0457	Tetratricopeptide repeat
HS042_RS07555	COG1598	PFAM Uncharacterised protein family UPF0150
HS042_RS07570	COG3038	cytochrome b561
HS042_RS07575	COG0436	Aminotransferase
HS042_RS07590	COG3275	phosphorelay sensor kinase activity
HS042_RS07595	COG3279	Response regulator of the LytR AlgR family
HS042_RS07605	COG2223	nitrite transmembrane transporter activity
HS042_RS07620	COG1794	racemase activity, acting on amino acids and derivatives
HS042_RS07635	COG3961	Belongs to the TPP enzyme family
HS042_RS07640	COG0667	Aldo Keto reductase
HS042_RS07650	COG1914	H( )-stimulated, divalent metal cation uptake system
HS042_RS07655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HS042_RS07670	COG2116	formate transmembrane transporter activity
HS042_RS07675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HS042_RS07705	COG4592	Periplasmic binding protein
HS042_RS07710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HS042_RS07715	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HS042_RS07720	COG1120	ATPase activity
HS042_RS07725	COG0747	negative chemotaxis
HS042_RS07745	COG4302	ethanolamine ammonia-lyase activity
HS042_RS07750	COG4303	Ethanolamine ammonia lyase large subunit
HS042_RS07765	COG0583	DNA-binding transcription factor activity
HS042_RS07770	COG0385	Bile acid
HS042_RS07775	COG3530	Putative quorum-sensing-regulated virulence factor
HS042_RS07780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HS042_RS07785	COG3115	cell septum assembly
HS042_RS07790	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HS042_RS07800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS042_RS07805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HS042_RS07815	COG2205	protein histidine kinase activity
HS042_RS07820	COG0745	RESPONSE REGULATOR receiver
HS042_RS07825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HS042_RS07835	COG4208	sulfate ABC transporter
HS042_RS07840	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HS042_RS07850	COG2837	iron assimilation
HS042_RS07865	COG3111	PFAM Bacterial OB fold (BOF) protein
HS042_RS07870	COG0456	acetyltransferase
HS042_RS07875	COG0860	N-Acetylmuramoyl-L-alanine amidase
HS042_RS07880	COG0408	coproporphyrinogen oxidase activity
HS042_RS07885	COG1671	Belongs to the UPF0178 family
HS042_RS07895	COG1770	oligopeptidase
HS042_RS07910	COG0833	amino acid
HS042_RS07915	COG2040	homocysteine
HS042_RS07960	COG0583	DNA-binding transcription factor activity
HS042_RS07965	COG3397	chitin binding
HS042_RS07980	COG2376	Dihydroxyacetone kinase
HS042_RS07985	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS07990	COG2814	Major facilitator Superfamily
HS042_RS07995	COG1063	alcohol dehydrogenase
HS042_RS08000	COG0698	ribose 5-phosphate isomerase
HS042_RS08005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HS042_RS08010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HS042_RS08015	COG0494	nUDIX hydrolase
HS042_RS08020	COG3850	Histidine kinase
HS042_RS08025	COG2197	response regulator
HS042_RS08035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HS042_RS08055	COG0454	-acetyltransferase
HS042_RS08065	COG1393	Belongs to the ArsC family
HS042_RS08070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS042_RS08075	COG1876	peptidase activity
HS042_RS08085	COG0400	carboxylic ester hydrolase activity
HS042_RS08090	COG1444	tRNA N-acetyltransferase activity
HS042_RS08095	COG2321	neutral zinc metallopeptidase
HS042_RS08100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HS042_RS08105	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HS042_RS08110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HS042_RS08115	COG2716	regulation of RNA biosynthetic process
HS042_RS08120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HS042_RS08125	COG0628	permease
HS042_RS08155	COG1522	sequence-specific DNA binding
HS042_RS08170	COG4783	chaperone-mediated protein folding
HS042_RS08175	COG1393	Belongs to the ArsC family
HS042_RS08180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HS042_RS08190	COG2261	transglycosylase associated protein
HS042_RS08195	COG2233	PERMEase
HS042_RS08200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HS042_RS08205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HS042_RS08210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HS042_RS08215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HS042_RS08270	COG0573	inorganic phosphate transmembrane transporter activity
HS042_RS08275	COG0573	inorganic phosphate transmembrane transporter activity
HS042_RS08280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HS042_RS08295	COG2239	Acts as a magnesium transporter
HS042_RS08300	COG5001	Diguanylate cyclase
HS042_RS08300	COG5002	protein histidine kinase activity
HS042_RS08300	COG3447	MASE1 domain protein
HS042_RS08315	COG0443	Heat shock 70 kDa protein
HS042_RS08330	COG0667	Aldo Keto reductase
HS042_RS08335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS042_RS08340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HS042_RS08345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HS042_RS08350	COG2814	Major facilitator Superfamily
HS042_RS08355	COG2205	protein histidine kinase activity
HS042_RS08360	COG0745	RESPONSE REGULATOR receiver
HS042_RS08375	COG3422	double-strand break repair
HS042_RS08380	COG0826	peptidase U32
HS042_RS08385	COG1597	lipid kinase activity
HS042_RS08395	COG1063	alcohol dehydrogenase
HS042_RS08400	COG2271	Major facilitator Superfamily
HS042_RS08405	COG0246	Mannitol dehydrogenase
HS042_RS08415	COG1802	Transcriptional regulator
HS042_RS08420	COG1830	Aldolase
HS042_RS08425	COG3730	PTS system glucitol sorbitol-specific
HS042_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS08445	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS042_RS08450	COG1349	DNA-binding transcription factor activity
HS042_RS08465	COG0351	phosphomethylpyrimidine kinase
HS042_RS08470	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HS042_RS08490	COG1289	transmembrane transporter activity
HS042_RS08500	COG2814	Major facilitator Superfamily
HS042_RS08510	COG1187	pseudouridine synthase activity
HS042_RS08530	COG0784	Response regulator, receiver
HS042_RS08530	COG2198	Histidine kinase
HS042_RS08530	COG2205	protein histidine kinase activity
HS042_RS08540	COG0519	Catalyzes the synthesis of GMP from XMP
HS042_RS08540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HS042_RS08545	COG0517	IMP dehydrogenase activity
HS042_RS08545	COG0516	GMP reductase activity
HS042_RS08550	COG1570	exodeoxyribonuclease VII activity
HS042_RS08560	COG2271	Major facilitator Superfamily
HS042_RS08565	COG1609	Transcriptional regulator
HS042_RS08580	COG1645	bacterial-type flagellum-dependent swarming motility
HS042_RS08590	COG1160	GTP binding
HS042_RS08595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS042_RS08600	COG2976	Protein conserved in bacteria
HS042_RS08605	COG0124	histidyl-tRNA synthetase
HS042_RS08610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HS042_RS08615	COG1426	Protein conserved in bacteria
HS042_RS08625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HS042_RS08630	COG0105	UTP biosynthetic process
HS042_RS08640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HS042_RS08645	COG2975	iron-sulfur cluster assembly
HS042_RS08650	COG0633	Ferredoxin
HS042_RS08655	COG0443	Heat shock 70 kDa protein
HS042_RS08660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HS042_RS08665	COG0316	Belongs to the HesB IscA family
HS042_RS08670	COG0822	iron-sulfur transferase activity
HS042_RS08675	COG1104	cysteine desulfurase activity
HS042_RS08680	COG1959	2 iron, 2 sulfur cluster binding
HS042_RS08695	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HS042_RS08700	COG3683	transport system, periplasmic component
HS042_RS08705	COG3711	transcriptional antiterminator
HS042_RS08710	COG2814	Major facilitator Superfamily
HS042_RS08715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HS042_RS08720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HS042_RS08720	COG1017	nitric oxide dioxygenase activity
HS042_RS08730	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HS042_RS08735	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS08740	COG1177	transmembrane transport
HS042_RS08745	COG1176	ABC-type spermidine putrescine transport system, permease component I
HS042_RS08750	COG3842	ATPase activity
HS042_RS08755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HS042_RS08765	COG0583	DNA-binding transcription factor activity
HS042_RS08770	COG0347	Belongs to the P(II) protein family
HS042_RS08775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HS042_RS08775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS042_RS08780	COG2204	response regulator
HS042_RS08785	COG3170	Tfp pilus assembly protein FimV
HS042_RS08790	COG2205	protein histidine kinase activity
HS042_RS08800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HS042_RS08815	COG0560	Phosphoserine phosphatase
HS042_RS08820	COG1263	PTS System
HS042_RS08820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS08825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HS042_RS08830	COG1737	Transcriptional regulator
HS042_RS08835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HS042_RS08840	COG0736	holo-[acyl-carrier-protein] synthase activity
HS042_RS08845	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HS042_RS08850	COG1381	Involved in DNA repair and RecF pathway recombination
HS042_RS08855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HS042_RS08860	COG0571	ribonuclease III activity
HS042_RS08870	COG0481	GTPase activity
HS042_RS08880	COG3086	response to oxidative stress
HS042_RS08885	COG3026	antisigma factor binding
HS042_RS08900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HS042_RS08905	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HS042_RS08910	COG0513	Belongs to the DEAD box helicase family
HS042_RS08930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HS042_RS08935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HS042_RS08940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HS042_RS08945	COG0497	DNA recombination
HS042_RS08950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS042_RS08955	COG2914	Belongs to the UPF0125 (RnfH) family
HS042_RS08960	COG2867	negative regulation of translational initiation
HS042_RS08965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HS042_RS08975	COG0582	viral genome integration into host DNA
HS042_RS09040	COG0495	leucyl-tRNA aminoacylation
HS042_RS09060	COG1619	proteins homologs of microcin C7 resistance protein MccF
HS042_RS09065	COG2226	methyltransferase
HS042_RS09130	COG1566	PFAM secretion protein HlyD family protein
HS042_RS09145	COG0583	DNA-binding transcription factor activity
HS042_RS09150	COG3182	Iron-regulated membrane protein
HS042_RS09160	COG0454	-acetyltransferase
HS042_RS09165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HS042_RS09180	COG2388	GCN5-related N-acetyl-transferase
HS042_RS09185	COG3592	Divergent 4Fe-4S mono-cluster
HS042_RS09190	COG2259	Doxx family
HS042_RS09195	COG2840	Smr protein MutS2
HS042_RS09215	COG0477	Major facilitator Superfamily
HS042_RS09225	COG0477	Major facilitator Superfamily
HS042_RS09240	COG4575	ribosome binding
HS042_RS09250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HS042_RS09255	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HS042_RS09260	COG1780	Probably involved in ribonucleotide reductase function
HS042_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS09285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HS042_RS09290	COG1752	Esterase of the alpha-beta hydrolase superfamily
HS042_RS09295	COG3493	citrate carrier protein
HS042_RS09320	COG4176	ABC-type proline glycine betaine transport system permease component
HS042_RS09325	COG2113	Glycine betaine
HS042_RS09330	COG0583	DNA-binding transcription factor activity
HS042_RS09335	COG2814	Major facilitator Superfamily
HS042_RS09340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HS042_RS09350	COG1846	Transcriptional regulator
HS042_RS09360	COG1566	PFAM secretion protein HlyD family protein
HS042_RS09365	COG2814	Major facilitator Superfamily
HS042_RS09370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HS042_RS09375	COG3118	belongs to the thioredoxin family
HS042_RS09380	COG3148	PFAM DTW domain containing protein
HS042_RS09385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HS042_RS09385	COG1042	CoA-binding domain protein
HS042_RS09385	COG0045	succinate-CoA ligase (ADP-forming) activity
HS042_RS09390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HS042_RS09395	COG0477	Major facilitator Superfamily
HS042_RS09425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HS042_RS09435	COG2011	ABC-type metal ion transport system permease component
HS042_RS09450	COG1720	tRNA m6t6A37 methyltransferase activity
HS042_RS09455	COG0442	prolyl-tRNA aminoacylation
HS042_RS09460	COG3015	lipoprotein NlpE involved in copper resistance
HS042_RS09465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HS042_RS09480	COG4568	rho-dependent transcription termination
HS042_RS09490	COG0037	tRNA processing
HS042_RS09495	COG3104	oligopeptide transport
HS042_RS09505	COG0531	amino acid
HS042_RS09510	COG3710	Transcriptional regulator
HS042_RS09515	COG0346	lactoylglutathione lyase activity
HS042_RS09520	COG1982	Orn Lys Arg decarboxylase major
HS042_RS09525	COG0825	malonyl-CoA metabolic process
HS042_RS09535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HS042_RS09540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HS042_RS09545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HS042_RS09550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HS042_RS09555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HS042_RS09560	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HS042_RS09565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS042_RS09570	COG0750	zinc metalloprotease
HS042_RS09575	COG0575	Belongs to the CDS family
HS042_RS09580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HS042_RS09585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HS042_RS09590	COG0233	cytoplasmic translational termination
HS042_RS09595	COG0528	UMP kinase activity
HS042_RS09605	COG0052	Belongs to the universal ribosomal protein uS2 family
HS042_RS09615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HS042_RS09635	COG0564	pseudouridine synthase activity
HS042_RS09640	COG4953	penicillin-binding protein 1C
HS042_RS09645	COG2373	Large extracellular alpha-helical protein
HS042_RS09650	COG3098	single-species biofilm formation
HS042_RS09655	COG2814	Major facilitator Superfamily
HS042_RS09670	COG1611	Belongs to the LOG family
HS042_RS09675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HS042_RS09680	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HS042_RS09685	COG2363	Small membrane protein
HS042_RS09690	COG0583	DNA-binding transcription factor activity
HS042_RS09700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HS042_RS09705	COG2166	iron-sulfur cluster assembly
HS042_RS09710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HS042_RS09715	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HS042_RS09735	COG0860	N-Acetylmuramoyl-L-alanine amidase
HS042_RS09740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HS042_RS09740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HS042_RS09745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HS042_RS09750	COG1074	ATP-dependent DNA helicase activity
HS042_RS09755	COG1025	Belongs to the peptidase M16 family
HS042_RS09760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HS042_RS09780	COG2165	general secretion pathway protein
HS042_RS09785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HS042_RS09790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HS042_RS09800	COG0494	nUDIX hydrolase
HS042_RS09805	COG3066	DNA modification
HS042_RS09810	COG0861	Integral membrane protein TerC family
HS042_RS09820	COG0667	Aldo Keto reductase
HS042_RS09825	COG0477	Major facilitator Superfamily
HS042_RS09830	COG0318	PFAM AMP-dependent synthetase and ligase
HS042_RS09830	COG0204	Acyl-transferase
HS042_RS09840	COG1609	Transcriptional regulator
HS042_RS09860	COG0583	DNA-binding transcription factor activity
HS042_RS09865	COG0583	DNA-binding transcription factor activity
HS042_RS09885	COG4178	(ABC) transporter
HS042_RS09895	COG3716	PTS system mannose fructose sorbose family IID component
HS042_RS09900	COG3715	PTS system
HS042_RS09905	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS09915	COG1349	DNA-binding transcription factor activity
HS042_RS09920	COG2807	transmembrane transport
HS042_RS09935	COG4615	Cyclic peptide transporter
HS042_RS09940	COG0583	DNA-binding transcription factor activity
HS042_RS09945	COG1620	l-lactate permease
HS042_RS09950	COG1304	FMN binding
HS042_RS09960	COG2814	Major facilitator Superfamily
HS042_RS09980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HS042_RS09985	COG1309	transcriptional regulator
HS042_RS09990	COG5265	(ABC) transporter
HS042_RS09995	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HS042_RS10000	COG4942	peptidase
HS042_RS10005	COG3247	response to pH
HS042_RS10030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HS042_RS10035	COG1609	Transcriptional regulator
HS042_RS10055	COG2731	YhcH YjgK YiaL family protein
HS042_RS10060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS042_RS10065	COG2271	Major facilitator Superfamily
HS042_RS10135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HS042_RS10145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HS042_RS10150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HS042_RS10155	COG4974	Belongs to the 'phage' integrase family
HS042_RS10160	COG0716	FMN binding
HS042_RS10170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HS042_RS10175	COG0354	folic acid binding
HS042_RS10185	COG1272	protein, Hemolysin III
HS042_RS10195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS042_RS10200	COG1940	carbohydrate kinase activity
HS042_RS10205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HS042_RS10215	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS10220	COG1129	ABC transporter
HS042_RS10230	COG1349	DNA-binding transcription factor activity
HS042_RS10245	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS10275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HS042_RS10275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HS042_RS10280	COG0509	glycine decarboxylation via glycine cleavage system
HS042_RS10285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HS042_RS10290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HS042_RS10295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HS042_RS10300	COG0006	proline dipeptidase activity
HS042_RS10305	COG3079	Belongs to the UPF0149 family
HS042_RS10310	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HS042_RS10320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HS042_RS10325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HS042_RS10335	COG0583	DNA-binding transcription factor activity
HS042_RS10345	COG1279	arginine transmembrane transporter activity
HS042_RS10355	COG3122	Protein conserved in bacteria
HS042_RS10370	COG2271	Major facilitator Superfamily
HS042_RS10385	COG0191	fructose-bisphosphate aldolase activity
HS042_RS10390	COG0126	phosphoglycerate kinase activity
HS042_RS10395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HS042_RS10400	COG0583	DNA-binding transcription factor activity
HS042_RS10405	COG0473	3-isopropylmalate dehydrogenase activity
HS042_RS10410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HS042_RS10415	COG4638	Rieske (2fe-2S)
HS042_RS10425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HS042_RS10430	COG3842	ATPase activity
HS042_RS10435	COG1175	transmembrane transport
HS042_RS10450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS042_RS10460	COG1114	Component of the transport system for branched-chain amino acids
HS042_RS10465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HS042_RS10470	COG0501	Belongs to the peptidase M48B family
HS042_RS10485	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HS042_RS10490	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS10495	COG2267	carboxylic ester hydrolase activity
HS042_RS10520	COG1414	Transcriptional regulator
HS042_RS10525	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS10540	COG2146	nitrite reductase [NAD(P)H] activity
HS042_RS10545	COG2271	Major facilitator Superfamily
HS042_RS10555	COG0010	Belongs to the arginase family
HS042_RS10560	COG1166	arginine decarboxylase activity
HS042_RS10565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HS042_RS10575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HS042_RS10580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HS042_RS10585	COG1120	ATPase activity
HS042_RS10590	COG4774	siderophore transport
HS042_RS10595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HS042_RS10600	COG1643	Atp-dependent helicase
HS042_RS10605	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HS042_RS10610	COG1489	DNA binding
HS042_RS10620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HS042_RS10625	COG0617	tRNA 3'-terminal CCA addition
HS042_RS10630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HS042_RS10635	COG0642	Histidine kinase
HS042_RS10645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HS042_RS10650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HS042_RS10655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HS042_RS10660	COG0726	polysaccharide deacetylase
HS042_RS10665	COG0842	Transport permease protein
HS042_RS10670	COG1131	(ABC) transporter
HS042_RS10675	COG0288	reversible hydration of carbon dioxide
HS042_RS10685	COG2132	Multicopper oxidase
HS042_RS10695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HS042_RS10700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HS042_RS10705	COG3112	Uncharacterised protein family (UPF0231)
HS042_RS10715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS042_RS10720	COG0508	dehydrogenase complex catalyzes the overall conversion of
HS042_RS10725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HS042_RS10730	COG2186	Transcriptional regulator
HS042_RS10735	COG1113	amino acid transport
HS042_RS10740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HS042_RS10740	COG2010	Cytochrome c
HS042_RS10750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HS042_RS10750	COG2010	Cytochrome c
HS042_RS10760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HS042_RS10765	COG2207	Transcriptional regulator
HS042_RS10765	COG3708	Transcriptional regulator
HS042_RS10775	COG3091	SprT-like family
HS042_RS10780	COG2356	endonuclease I
HS042_RS10785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HS042_RS10790	COG0189	ligase activity
HS042_RS10795	COG1678	Uncharacterized ACR, COG1678
HS042_RS10800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HS042_RS10805	COG2805	Type II/IV secretion system protein
HS042_RS10810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HS042_RS10815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HS042_RS10820	COG0762	integral membrane protein
HS042_RS10825	COG1872	DUF167
HS042_RS10835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HS042_RS10855	COG2066	Belongs to the glutaminase family
HS042_RS10860	COG3171	Protein conserved in bacteria
HS042_RS10865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HS042_RS10875	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HS042_RS10880	COG0741	lytic transglycosylase activity
HS042_RS10885	COG1982	Orn Lys Arg decarboxylase major
HS042_RS10920	COG2819	hydrolase of the alpha beta superfamily
HS042_RS10925	COG0454	-acetyltransferase
HS042_RS10950	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HS042_RS10950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HS042_RS10965	COG4772	TonB-dependent receptor
HS042_RS10970	COG0583	DNA-binding transcription factor activity
HS042_RS10975	COG1473	amidohydrolase
HS042_RS10980	COG1473	amidohydrolase
HS042_RS10985	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HS042_RS11015	COG0848	biopolymer transport protein
HS042_RS11030	COG0586	Pfam SNARE associated Golgi protein
HS042_RS11035	COG0583	DNA-binding transcription factor activity
HS042_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS11040	COG0604	alcohol dehydrogenase
HS042_RS11040	COG3321	synthase
HS042_RS11045	COG2207	Transcriptional regulator
HS042_RS11050	COG1979	alcohol dehydrogenase
HS042_RS11055	COG0656	L-ascorbic acid biosynthetic process
HS042_RS11060	COG0741	lytic transglycosylase activity
HS042_RS11070	COG2186	Transcriptional regulator
HS042_RS11080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS042_RS11085	COG2211	Major facilitator Superfamily
HS042_RS11090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HS042_RS11095	COG0583	DNA-binding transcription factor activity
HS042_RS11100	COG2132	Multicopper oxidase
HS042_RS11105	COG0204	Acyl-transferase
HS042_RS11110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HS042_RS11115	COG2249	NAD(P)H dehydrogenase (quinone) activity
HS042_RS11120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HS042_RS11125	COG0583	DNA-binding transcription factor activity
HS042_RS11130	COG0187	DNA topoisomerase II activity
HS042_RS11135	COG3150	esterase
HS042_RS11140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HS042_RS11145	COG3151	Protein conserved in bacteria
HS042_RS11150	COG0494	nUDIX hydrolase
HS042_RS11155	COG1538	Outer membrane efflux protein
HS042_RS11165	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HS042_RS11165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS042_RS11165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HS042_RS11170	COG1461	Dihydroxyacetone kinase
HS042_RS11175	COG2376	Dihydroxyacetone kinase
HS042_RS11185	COG5463	Belongs to the UPF0441 family
HS042_RS11190	COG0754	glutathionylspermidine amidase activity
HS042_RS11195	COG3384	dioxygenase
HS042_RS11205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HS042_RS11215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HS042_RS11215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HS042_RS11220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HS042_RS11225	COG3025	triphosphatase activity
HS042_RS11230	COG4991	sh3 domain protein
HS042_RS11235	COG0617	tRNA 3'-terminal CCA addition
HS042_RS11240	COG1968	undecaprenyl-diphosphatase activity
HS042_RS11245	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HS042_RS11250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HS042_RS11255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HS042_RS11260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HS042_RS11265	COG0358	DNA primase activity
HS042_RS11290	COG1733	regulation of RNA biosynthetic process
HS042_RS11295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HS042_RS11315	COG0625	glutathione transferase activity
HS042_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS11330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HS042_RS11340	COG0488	(ABC) transporter
HS042_RS11345	COG1902	pentaerythritol trinitrate reductase activity
HS042_RS11345	COG0446	pyridine nucleotide-disulphide oxidoreductase
HS042_RS11350	COG2813	Specifically methylates the guanine in position
HS042_RS11355	COG3549	Plasmid maintenance system killer
HS042_RS11360	COG3093	addiction module antidote protein HigA
HS042_RS11365	COG1451	nucleotide metabolic process
HS042_RS11370	COG0673	inositol 2-dehydrogenase activity
HS042_RS11375	COG0519	Catalyzes the synthesis of GMP from XMP
HS042_RS11375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HS042_RS11380	COG0861	Integral membrane protein TerC family
HS042_RS11385	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HS042_RS11390	COG2721	sulfolactate sulfo-lyase activity
HS042_RS11395	COG1904	glucuronate isomerase
HS042_RS11400	COG2271	Major facilitator Superfamily
HS042_RS11415	COG0586	Pfam SNARE associated Golgi protein
HS042_RS11420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HS042_RS11430	COG4575	ribosome binding
HS042_RS11435	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HS042_RS11445	COG2259	Doxx family
HS042_RS11450	COG0435	Glutathione S-transferase
HS042_RS11455	COG0583	DNA-binding transcription factor activity
HS042_RS11460	COG1741	Belongs to the pirin family
HS042_RS11470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HS042_RS11475	COG3107	peptidoglycan biosynthetic process
HS042_RS11480	COG0792	nuclease activity
HS042_RS11485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HS042_RS11490	COG2823	Periplasmic or secreted lipoprotein
HS042_RS11500	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HS042_RS11505	COG0784	Response regulator, receiver
HS042_RS11505	COG2198	Histidine kinase
HS042_RS11505	COG5002	protein histidine kinase activity
HS042_RS11510	COG1242	4 iron, 4 sulfur cluster binding
HS042_RS11515	COG0069	glutamate synthase activity
HS042_RS11515	COG0070	glutamate synthase
HS042_RS11515	COG0067	glutamate synthase
HS042_RS11520	COG0493	'glutamate synthase
HS042_RS11530	COG2969	positive regulation of protein catabolic process
HS042_RS11535	COG0625	glutathione transferase activity
HS042_RS11540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HS042_RS11545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HS042_RS11550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HS042_RS11555	COG3105	Protein conserved in bacteria
HS042_RS11560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HS042_RS11565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HS042_RS11570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HS042_RS11575	COG5007	Belongs to the BolA IbaG family
HS042_RS11580	COG3113	response to antibiotic
HS042_RS11585	COG2854	intermembrane phospholipid transfer
HS042_RS11590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HS042_RS11595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HS042_RS11600	COG1127	ABC transporter
HS042_RS11605	COG0530	calcium, potassium:sodium antiporter activity
HS042_RS11610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HS042_RS11610	COG0517	IMP dehydrogenase activity
HS042_RS11615	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HS042_RS11620	COG3117	lipopolysaccharide transmembrane transporter activity
HS042_RS11625	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HS042_RS11630	COG1137	ATPase activity
HS042_RS11635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HS042_RS11650	COG1660	Displays ATPase and GTPase activities
HS042_RS11655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS042_RS11660	COG4680	protein conserved in bacteria
HS042_RS11665	COG5499	transcription regulator containing HTH domain
HS042_RS11670	COG3711	transcriptional antiterminator
HS042_RS11670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS042_RS11690	COG3964	amidohydrolase
HS042_RS11720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HS042_RS11730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HS042_RS11740	COG2207	Transcriptional regulator
HS042_RS11745	COG3783	Cytochrome b(562)
HS042_RS11750	COG0312	modulator of DNA gyrase
HS042_RS11755	COG3028	Belongs to the UPF0307 family
HS042_RS11760	COG2732	(Barnase) inhibitor
HS042_RS11770	COG1289	transmembrane transporter activity
HS042_RS11775	COG1566	PFAM secretion protein HlyD family protein
HS042_RS11785	COG0583	DNA-binding transcription factor activity
HS042_RS11810	COG2134	cdp-diacylglycerol pyrophosphatase
HS042_RS11815	COG0312	modulator of DNA gyrase
HS042_RS11820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS042_RS11825	COG3164	Protein of unknown function
HS042_RS11830	COG1530	ribonuclease E activity
HS042_RS11835	COG0424	maF-like protein
HS042_RS11840	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HS042_RS11845	COG1792	Involved in formation and maintenance of cell shape
HS042_RS11850	COG1077	Cell shape determining protein MreB Mrl
HS042_RS11855	COG2200	EAL domain
HS042_RS11855	COG2199	diguanylate cyclase activity
HS042_RS11860	COG0604	alcohol dehydrogenase
HS042_RS11865	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HS042_RS11870	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HS042_RS11875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HS042_RS11880	COG0511	ligase activity, forming carbon-carbon bonds
HS042_RS11885	COG0439	Biotin carboxylase
HS042_RS11895	COG0039	L-malate dehydrogenase activity
HS042_RS11905	COG2211	Major facilitator Superfamily
HS042_RS11915	COG3924	membrane
HS042_RS11920	COG4145	pantothenate transmembrane transporter activity
HS042_RS11925	COG2264	protein methyltransferase activity
HS042_RS11955	COG1560	Kdo2-lipid A biosynthetic process
HS042_RS11965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HS042_RS11965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HS042_RS11975	COG1380	Effector of murein hydrolase LrgA
HS042_RS11980	COG0583	DNA-binding transcription factor activity
HS042_RS11985	COG0025	NhaP-type Na H and K H
HS042_RS11990	COG2252	PERMEase
HS042_RS12000	COG0625	glutathione transferase activity
HS042_RS12015	COG0583	DNA-binding transcription factor activity
HS042_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS12040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HS042_RS12045	COG1064	alcohol dehydrogenase
HS042_RS12050	COG0110	maltose O-acetyltransferase activity
HS042_RS12055	COG2315	Protein conserved in bacteria
HS042_RS12060	COG0432	Pfam Uncharacterised protein family UPF0047
HS042_RS12065	COG1448	Aminotransferase
HS042_RS12070	COG1522	sequence-specific DNA binding
HS042_RS12090	COG0604	alcohol dehydrogenase
HS042_RS12100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HS042_RS12120	COG0735	belongs to the Fur family
HS042_RS12125	COG3237	CsbD-like
HS042_RS12130	COG0534	Mate efflux family protein
HS042_RS12135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HS042_RS12140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HS042_RS12145	COG2937	Belongs to the GPAT DAPAT family
HS042_RS12150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HS042_RS12155	COG3161	chorismate lyase activity
HS042_RS12160	COG0477	Major facilitator Superfamily
HS042_RS12165	COG1609	Transcriptional regulator
HS042_RS12180	COG4580	involved in the transport of maltose and maltodextrins
HS042_RS12190	COG0366	Alpha amylase catalytic
HS042_RS12195	COG2182	Extracellular solute-binding protein
HS042_RS12200	COG1175	transmembrane transport
HS042_RS12205	COG3833	ABC-type maltose transport systems, permease component
HS042_RS12210	COG3223	Belongs to the PsiE family
HS042_RS12220	COG0166	Belongs to the GPI family
HS042_RS12230	COG0527	aspartate kinase activity
HS042_RS12250	COG1283	sodium-dependent phosphate transmembrane transporter activity
HS042_RS12255	COG3842	ATPase activity
HS042_RS12265	COG0395	ABC-type sugar transport system, permease component
HS042_RS12270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HS042_RS12280	COG2188	Transcriptional regulator
HS042_RS12285	COG0646	methionine synthase
HS042_RS12285	COG1410	methionine synthase
HS042_RS12290	COG1414	Transcriptional regulator
HS042_RS12295	COG3265	gluconokinase activity
HS042_RS12300	COG2610	gluconate transmembrane transporter activity
HS042_RS12305	COG0129	dihydroxy-acid dehydratase activity
HS042_RS12310	COG0800	Aldolase
HS042_RS12315	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HS042_RS12325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HS042_RS12330	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HS042_RS12365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HS042_RS12370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HS042_RS12375	COG0009	L-threonylcarbamoyladenylate synthase
HS042_RS12380	COG0551	DNA topoisomerase type I activity
HS042_RS12385	COG2922	Belongs to the Smg family
HS042_RS12390	COG0758	DNA mediated transformation
HS042_RS12395	COG0242	peptide deformylase activity
HS042_RS12400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HS042_RS12405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HS042_RS12405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HS042_RS12410	COG0569	domain protein
HS042_RS12415	COG1970	mechanosensitive ion channel activity
HS042_RS12420	COG3036	rescue of stalled ribosome
HS042_RS12425	COG0789	Transcriptional regulator
HS042_RS12435	COG0203	ribosomal protein L17
HS042_RS12440	COG0202	RNA polymerase activity
HS042_RS12445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HS042_RS12450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HS042_RS12455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HS042_RS12460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HS042_RS12465	COG0201	protein transport
HS042_RS12475	COG1841	ribosomal large subunit assembly
HS042_RS12480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HS042_RS12485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HS042_RS12490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HS042_RS12530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HS042_RS12535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HS042_RS12545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HS042_RS12555	COG0089	rRNA binding
HS042_RS12560	COG0088	Forms part of the polypeptide exit tunnel
HS042_RS12565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HS042_RS12570	COG0051	transcription antitermination factor activity, RNA binding
HS042_RS12585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HS042_RS12595	COG0049	tRNA binding
HS042_RS12600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HS042_RS12605	COG2168	tRNA wobble position uridine thiolation
HS042_RS12610	COG2923	Belongs to the DsrF TusC family
HS042_RS12615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HS042_RS12620	COG2964	Protein conserved in bacteria
HS042_RS12625	COG0545	Peptidyl-prolyl cis-trans isomerase
HS042_RS12630	COG2900	Belongs to the SlyX family
HS042_RS12635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HS042_RS12640	COG1757	Na H antiporter
HS042_RS12645	COG1609	Transcriptional regulator
HS042_RS12650	COG1047	Peptidyl-prolyl cis-trans
HS042_RS12655	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HS042_RS12665	COG2249	NAD(P)H dehydrogenase (quinone) activity
HS042_RS12670	COG0488	(ABC) transporter
HS042_RS12675	COG2175	clavaminate synthase activity
HS042_RS12680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HS042_RS12690	COG4521	taurine ABC transporter
HS042_RS12705	COG0429	hydrolase of the alpha beta-hydrolase fold
HS042_RS12710	COG3089	Belongs to the UPF0270 family
HS042_RS12715	COG3954	Phosphoribulokinase
HS042_RS12720	COG1765	OsmC-like protein
HS042_RS12725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HS042_RS12730	COG1289	transmembrane transporter activity
HS042_RS12745	COG0433	COG0433 Predicted ATPase
HS042_RS12765	COG3275	phosphorelay sensor kinase activity
HS042_RS12770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HS042_RS12775	COG1447	Phosphotransferase system cellobiose-specific component IIA
HS042_RS12780	COG1486	melibiose metabolic process
HS042_RS12785	COG1609	Transcriptional regulator
HS042_RS12790	COG0738	Major facilitator superfamily
HS042_RS12795	COG0402	S-adenosylhomocysteine deaminase activity
HS042_RS12800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HS042_RS12815	COG1648	precorrin-2 dehydrogenase activity
HS042_RS12815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HS042_RS12820	COG0180	Tryptophanyl-tRNA synthetase
HS042_RS12825	COG0546	phosphoglycolate phosphatase activity
HS042_RS12845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HS042_RS12850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HS042_RS12855	COG4796	Type ii and iii secretion system protein
HS042_RS12880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HS042_RS12885	COG0494	nUDIX hydrolase
HS042_RS12895	COG1011	Hydrolase
HS042_RS12900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HS042_RS12905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HS042_RS12920	COG1487	ribonuclease activity
HS042_RS12940	COG0484	heat shock protein binding
HS042_RS12945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HS042_RS12950	COG2183	response to ionizing radiation
HS042_RS12955	COG1918	ferrous iron import across plasma membrane
HS042_RS12980	COG1040	competence protein
HS042_RS12985	COG0316	Belongs to the HesB IscA family
HS042_RS12985	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HS042_RS12990	COG1640	4-alpha-glucanotransferase
HS042_RS12995	COG0058	SHG alpha-glucan phosphorylase activity
HS042_RS13000	COG2909	trisaccharide binding
HS042_RS13005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HS042_RS13010	COG0705	Rhomboid family
HS042_RS13015	COG1349	DNA-binding transcription factor activity
HS042_RS13020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HS042_RS13025	COG0058	SHG alpha-glucan phosphorylase activity
HS042_RS13030	COG0297	glycogen (starch) synthase activity
HS042_RS13035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HS042_RS13040	COG1523	belongs to the glycosyl hydrolase 13 family
HS042_RS13045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HS042_RS13050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HS042_RS13055	COG2095	MarC family integral membrane protein
HS042_RS13060	COG3265	gluconokinase activity
HS042_RS13065	COG2610	gluconate transmembrane transporter activity
HS042_RS13070	COG1609	Transcriptional regulator
HS042_RS13075	COG1741	Belongs to the pirin family
HS042_RS13080	COG1247	-acetyltransferase
HS042_RS13085	COG3191	aminopeptidase activity
HS042_RS13090	COG1082	Xylose isomerase domain protein TIM barrel
HS042_RS13095	COG1082	Xylose isomerase domain protein TIM barrel
HS042_RS13100	COG0673	inositol 2-dehydrogenase activity
HS042_RS13105	COG3962	Belongs to the TPP enzyme family
HS042_RS13110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS042_RS13130	COG3718	enzyme involved in inositol metabolism
HS042_RS13140	COG0477	Major facilitator Superfamily
HS042_RS13140	COG2814	Major facilitator Superfamily
HS042_RS13150	COG0390	transport system, permease component
HS042_RS13155	COG4619	ABC transporter
HS042_RS13185	COG3188	usher protein
HS042_RS13210	COG2197	response regulator
HS042_RS13220	COG0697	spore germination
HS042_RS13240	COG0583	DNA-binding transcription factor activity
HS042_RS13250	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS13280	COG2081	HI0933 family
HS042_RS13285	COG0306	phosphate transporter
HS042_RS13300	COG0583	DNA-binding transcription factor activity
HS042_RS13305	COG0589	response to stress
HS042_RS13320	COG1129	ABC transporter
HS042_RS13325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS13330	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS13345	COG0742	ribosomal rna small subunit methyltransferase
HS042_RS13350	COG0339	signal peptide processing
HS042_RS13365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HS042_RS13370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS042_RS13375	COG2318	DinB family
HS042_RS13390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HS042_RS13425	COG5441	Belongs to the UPF0261 family
HS042_RS13430	COG3678	ATP-independent chaperone mediated protein folding
HS042_RS13435	COG5001	Diguanylate cyclase
HS042_RS13440	COG1024	Enoyl-CoA hydratase
HS042_RS13445	COG1295	ribonuclease BN
HS042_RS13450	COG0477	Major facilitator Superfamily
HS042_RS13455	COG2134	cdp-diacylglycerol pyrophosphatase
HS042_RS13460	COG2982	Protein involved in outer membrane biogenesis
HS042_RS13465	COG2200	EAL domain
HS042_RS13470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS042_RS13480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HS042_RS13505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HS042_RS13510	COG0129	dihydroxy-acid dehydratase activity
HS042_RS13515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HS042_RS13520	COG3978	acetolactate synthase activity
HS042_RS13535	COG2814	Major facilitator Superfamily
HS042_RS13545	COG3085	chromosome segregation
HS042_RS13590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HS042_RS13595	COG4206	TonB-dependent receptor
HS042_RS13600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HS042_RS13615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS042_RS13625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HS042_RS13625	COG0678	peroxiredoxin activity
HS042_RS13630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS042_RS13640	COG0165	Argininosuccinate lyase
HS042_RS13645	COG0137	argininosuccinate synthase activity
HS042_RS13650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HS042_RS13665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HS042_RS13675	COG0460	homoserine dehydrogenase
HS042_RS13675	COG0527	aspartate kinase activity
HS042_RS13680	COG0626	cystathionine gamma-synthase activity
HS042_RS13685	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HS042_RS13690	COG0254	rRNA binding
HS042_RS13695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HS042_RS13700	COG1609	Transcriptional regulator
HS042_RS13705	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HS042_RS13710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HS042_RS13715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HS042_RS13720	COG1575	Belongs to the MenA family. Type 1 subfamily
HS042_RS13725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HS042_RS13730	COG3074	FtsZ-dependent cytokinesis
HS042_RS13745	COG1494	fructose-1,6-bisphosphatase
HS042_RS13750	COG2814	Major facilitator Superfamily
HS042_RS13765	COG3152	Membrane
HS042_RS13775	COG0149	triose-phosphate isomerase activity
HS042_RS13780	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HS042_RS13785	COG0205	6-phosphofructokinase activity
HS042_RS13790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HS042_RS13795	COG3678	ATP-independent chaperone mediated protein folding
HS042_RS13800	COG0745	RESPONSE REGULATOR receiver
HS042_RS13805	COG2205	protein histidine kinase activity
HS042_RS13810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HS042_RS13825	COG1045	serine acetyltransferase
HS042_RS13840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HS042_RS13845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HS042_RS13850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HS042_RS13855	COG4942	peptidase
HS042_RS13860	COG2861	carbohydrate metabolic process
HS042_RS13870	COG0156	8-amino-7-oxononanoate synthase activity
HS042_RS13875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HS042_RS13880	COG0859	PFAM glycosyl transferase family 9
HS042_RS13885	COG0859	PFAM glycosyl transferase family 9
HS042_RS13890	COG0438	transferase activity, transferring glycosyl groups
HS042_RS13895	COG3307	-O-antigen
HS042_RS13900	COG1442	glycosyl transferase family 8
HS042_RS13900	COG1216	Glycosyl transferase, family 2
HS042_RS13915	COG0859	PFAM glycosyl transferase family 9
HS042_RS13920	COG0438	transferase activity, transferring glycosyl groups
HS042_RS13925	COG0438	transferase activity, transferring glycosyl groups
HS042_RS13935	COG1519	Transferase
HS042_RS13955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HS042_RS13960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HS042_RS13965	COG2003	Belongs to the UPF0758 family
HS042_RS13970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HS042_RS13975	COG0756	dUTP diphosphatase activity
HS042_RS13980	COG1309	transcriptional regulator
HS042_RS13985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HS042_RS13990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HS042_RS13995	COG1561	YicC-like family, N-terminal region
HS042_RS14005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HS042_RS14015	COG2860	membrane
HS042_RS14020	COG0194	GDP metabolic process
HS042_RS14025	COG1758	RNA polymerase activity
HS042_RS14030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HS042_RS14035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HS042_RS14040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HS042_RS14045	COG0786	glutamate:sodium symporter activity
HS042_RS14050	COG2233	PERMEase
HS042_RS14055	COG2982	Protein involved in outer membrane biogenesis
HS042_RS14060	COG0456	acetyltransferase
HS042_RS14065	COG1490	D-aminoacyl-tRNA deacylase activity
HS042_RS14070	COG1295	ribonuclease BN
HS042_RS14075	COG1011	Hydrolase
HS042_RS14080	COG1217	gtp-binding protein TYPA
HS042_RS14090	COG3852	Histidine kinase
HS042_RS14105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HS042_RS14110	COG3078	GTPase activator activity
HS042_RS14115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HS042_RS14120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HS042_RS14120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HS042_RS14125	COG0204	Acyl-transferase
HS042_RS14130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HS042_RS14135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HS042_RS14140	COG3084	Protein conserved in bacteria
HS042_RS14145	COG0746	molybdenum cofactor guanylyltransferase activity
HS042_RS14150	COG1763	Mo-molybdopterin cofactor biosynthetic process
HS042_RS14175	COG2186	Transcriptional regulator
HS042_RS14180	COG0477	Major facilitator Superfamily
HS042_RS14185	COG1609	Transcriptional regulator
HS042_RS14190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS042_RS14195	COG1879	ABC-type sugar transport system periplasmic component
HS042_RS14200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS14205	COG1129	ABC transporter
HS042_RS14210	COG1869	D-ribose catabolic process
HS042_RS14215	COG3158	transport of potassium into the cell
HS042_RS14220	COG0714	Associated with various cellular activities
HS042_RS14225	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HS042_RS14230	COG2502	aspartate--ammonia ligase
HS042_RS14235	COG1522	sequence-specific DNA binding
HS042_RS14240	COG0716	FMN binding
HS042_RS14245	COG0445	tRNA wobble uridine modification
HS042_RS14250	COG0357	Ribosomal RNA small subunit methyltransferase G
HS042_RS14255	COG3312	ion transport
HS042_RS14270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HS042_RS14275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HS042_RS14280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HS042_RS14285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HS042_RS14290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HS042_RS14295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HS042_RS14300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HS042_RS14310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HS042_RS14315	COG0573	inorganic phosphate transmembrane transporter activity
HS042_RS14320	COG0581	inorganic phosphate transmembrane transporter activity
HS042_RS14330	COG0704	Plays a role in the regulation of phosphate uptake
HS042_RS14335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS14340	COG0765	amino acid transport
HS042_RS14345	COG0765	amino acid transport
HS042_RS14350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HS042_RS14355	COG0494	nUDIX hydrolase
HS042_RS14360	COG2252	PERMEase
HS042_RS14370	COG0431	NADPH-dependent FMN reductase
HS042_RS14375	COG2091	lysine biosynthetic process via aminoadipic acid
HS042_RS14400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HS042_RS14405	COG0706	membrane insertase activity
HS042_RS14410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HS042_RS14415	COG0594	ribonuclease P activity
HS042_RS14430	COG0592	DNA-directed DNA polymerase activity
HS042_RS14435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS042_RS14440	COG0187	DNA topoisomerase II activity
HS042_RS14445	COG0561	phosphatase activity
HS042_RS14465	COG0823	Involved in the tonB-independent uptake of proteins
HS042_RS14470	COG5645	(Lipo)protein
HS042_RS14475	COG0071	Belongs to the small heat shock protein (HSP20) family
HS042_RS14480	COG0071	Belongs to the small heat shock protein (HSP20) family
HS042_RS14485	COG2985	domain, Protein
HS042_RS14490	COG3977	Valine--pyruvate aminotransferase
HS042_RS14495	COG0366	Alpha amylase catalytic
HS042_RS14505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS042_RS14510	COG2814	Major facilitator Superfamily
HS042_RS14515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS042_RS14525	COG1609	Transcriptional regulator
HS042_RS14530	COG2885	chlorophyll binding
HS042_RS14540	COG2818	Glycosylase
HS042_RS14550	COG0752	glycyl-tRNA synthetase alpha subunit
HS042_RS14555	COG0751	glycine-tRNA ligase activity
HS042_RS14565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HS042_RS14565	COG2213	PTS system mannitol-specific
HS042_RS14570	COG0246	Mannitol dehydrogenase
HS042_RS14575	COG3722	fumarate hydratase activity
HS042_RS14585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HS042_RS14600	COG2258	MOSC domain
HS042_RS14610	COG0840	transmembrane signaling receptor activity
HS042_RS14615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HS042_RS14625	COG0437	4 iron, 4 sulfur cluster binding
HS042_RS14630	COG2864	formate dehydrogenase
HS042_RS14635	COG3058	Necessary for formate dehydrogenase activity
HS042_RS14645	COG0625	glutathione transferase activity
HS042_RS14650	COG1921	L-seryl-tRNASec selenium transferase activity
HS042_RS14655	COG3276	selenocysteine insertion sequence binding
HS042_RS14675	COG3274	enterobacterial common antigen metabolic process
HS042_RS14685	COG1335	isochorismatase
HS042_RS14690	COG0402	S-adenosylhomocysteine deaminase activity
HS042_RS14705	COG0583	DNA-binding transcription factor activity
HS042_RS14710	COG2807	transmembrane transport
HS042_RS14770	COG1902	pentaerythritol trinitrate reductase activity
HS042_RS14775	COG2814	Major facilitator Superfamily
HS042_RS14805	COG1846	Transcriptional regulator
HS042_RS14810	COG1764	response to oxidative stress
HS042_RS14815	COG2194	sulfuric ester hydrolase activity
HS042_RS14820	COG2197	response regulator
HS042_RS14830	COG2271	Major facilitator Superfamily
HS042_RS14865	COG0747	negative chemotaxis
HS042_RS14870	COG0601	transmembrane transport
HS042_RS14875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HS042_RS14880	COG0444	Belongs to the ABC transporter superfamily
HS042_RS14885	COG4608	Belongs to the ABC transporter superfamily
HS042_RS14890	COG2194	sulfuric ester hydrolase activity
HS042_RS14915	COG1215	transferase activity, transferring glycosyl groups
HS042_RS14920	COG1215	transferase activity, transferring glycosyl groups
HS042_RS14925	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HS042_RS14930	COG3118	belongs to the thioredoxin family
HS042_RS14930	COG0457	Tetratricopeptide repeat
HS042_RS14935	COG2199	diguanylate cyclase activity
HS042_RS14935	COG2200	EAL domain
HS042_RS14940	COG1301	dicarboxylic acid transport
HS042_RS14945	COG0612	Peptidase, M16
HS042_RS14950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HS042_RS14960	COG0248	Ppx GppA phosphatase
HS042_RS14970	COG3118	belongs to the thioredoxin family
HS042_RS14975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HS042_RS14980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HS042_RS14990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HS042_RS14995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HS042_RS15000	COG1088	dTDP-glucose 4,6-dehydratase activity
HS042_RS15005	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HS042_RS15010	COG0456	acetyltransferase
HS042_RS15015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HS042_RS15020	COG2244	polysaccharide biosynthetic process
HS042_RS15025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HS042_RS15035	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HS042_RS15070	COG3071	HemY protein
HS042_RS15075	COG2959	enzyme of heme biosynthesis
HS042_RS15085	COG0181	hydroxymethylbilane synthase activity
HS042_RS15090	COG3072	Adenylate cyclase
HS042_RS15095	COG1965	Belongs to the frataxin family
HS042_RS15100	COG5567	small periplasmic lipoprotein
HS042_RS15105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HS042_RS15110	COG3159	Protein conserved in bacteria
HS042_RS15120	COG1011	Hydrolase
HS042_RS15125	COG0210	DNA helicase
HS042_RS15145	COG2050	protein possibly involved in aromatic compounds catabolism
HS042_RS15155	COG0514	ATP-dependent DNA helicase (RecQ)
HS042_RS15160	COG1280	lysine exporter protein (LysE YggA)
HS042_RS15165	COG1280	lysine exporter protein (LysE YggA)
HS042_RS15170	COG2267	carboxylic ester hydrolase activity
HS042_RS15175	COG0561	phosphatase activity
HS042_RS15180	COG0584	glycerophosphoryl diester phosphodiesterase
HS042_RS15185	COG2271	Major facilitator Superfamily
HS042_RS15190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HS042_RS15200	COG0247	lactate metabolic process
HS042_RS15215	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HS042_RS15220	COG0425	Belongs to the sulfur carrier protein TusA family
HS042_RS15225	COG2217	Heavy metal translocating P-type atpase
HS042_RS15240	COG3714	YhhN family
HS042_RS15250	COG3776	membrane
HS042_RS15255	COG0742	ribosomal rna small subunit methyltransferase
HS042_RS15260	COG0552	protein localization to endoplasmic reticulum
HS042_RS15260	COG0552	protein localization to endoplasmic reticulum
HS042_RS15265	COG2884	Cell division ATP-binding protein ftsE
HS042_RS15270	COG2177	Part of the ABC transporter FtsEX involved in
HS042_RS15290	COG0456	acetyltransferase
HS042_RS15300	COG0559	Belongs to the binding-protein-dependent transport system permease family
HS042_RS15305	COG4177	L-phenylalanine transmembrane transporter activity
HS042_RS15320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HS042_RS15325	COG1653	transport
HS042_RS15330	COG1175	transmembrane transport
HS042_RS15340	COG3842	ATPase activity
HS042_RS15345	COG0584	glycerophosphoryl diester phosphodiesterase
HS042_RS15360	COG0697	spore germination
HS042_RS15370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HS042_RS15375	COG0412	Dienelactone hydrolase
HS042_RS15390	COG0586	Pfam SNARE associated Golgi protein
HS042_RS15395	COG1322	Protein conserved in bacteria
HS042_RS15400	COG2226	methyltransferase
HS042_RS15405	COG3165	ubiquinone biosynthetic process from chorismate
HS042_RS15410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HS042_RS15415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HS042_RS15425	COG0805	protein transport
HS042_RS15430	COG0084	hydrolase, TatD family'
HS042_RS15490	COG0183	Belongs to the thiolase family
HS042_RS15495	COG1024	Enoyl-CoA hydratase
HS042_RS15495	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS042_RS15505	COG0006	proline dipeptidase activity
HS042_RS15510	COG1739	Uncharacterized protein family UPF0029
HS042_RS15515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HS042_RS15545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HS042_RS15550	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HS042_RS15550	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HS042_RS15555	COG1072	(Pantothenic acid kinase))
HS042_RS15590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HS042_RS15600	COG0250	Participates in transcription elongation, termination and antitermination
HS042_RS15615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HS042_RS15625	COG0085	RNA polymerase activity
HS042_RS15630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HS042_RS15660	COG2022	thiamine diphosphate biosynthetic process
HS042_RS15665	COG2104	thiamine diphosphate biosynthetic process
HS042_RS15670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HS042_RS15675	COG0352	thiamine-phosphate diphosphorylase activity
HS042_RS15680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HS042_RS15685	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HS042_RS15690	COG2816	NAD+ diphosphatase activity
HS042_RS15695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HS042_RS15700	COG1515	deoxyribonuclease V activity
HS042_RS15720	COG0151	Belongs to the GarS family
HS042_RS15725	COG0138	bifunctional purine biosynthesis protein purh
HS042_RS15755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HS042_RS15760	COG3162	membrane
HS042_RS15765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS042_RS15770	COG1301	dicarboxylic acid transport
HS042_RS15775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HS042_RS15775	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HS042_RS15780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HS042_RS15780	COG3433	isochorismatase activity
HS042_RS15780	COG2226	methyltransferase
HS042_RS15785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HS042_RS15790	COG1629	transport
HS042_RS15790	COG4774	siderophore transport
HS042_RS15795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HS042_RS15800	COG3391	amine dehydrogenase activity
HS042_RS15805	COG4771	TonB-dependent receptor
HS042_RS15810	COG2382	esterase
HS042_RS15820	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HS042_RS15820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HS042_RS15830	COG1169	isochorismate synthase
HS042_RS15835	COG1021	2,3-dihydroxybenzoate-AMP ligase
HS042_RS15840	COG1535	isochorismatase
HS042_RS15840	COG3433	isochorismatase activity
HS042_RS15850	COG3647	Membrane
HS042_RS15855	COG0745	RESPONSE REGULATOR receiver
HS042_RS15880	COG3188	usher protein
HS042_RS15885	COG3121	Chaperone
HS042_RS15930	COG0583	DNA-binding transcription factor activity
HS042_RS15935	COG2814	Major facilitator Superfamily
HS042_RS15960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HS042_RS15975	COG1309	transcriptional regulator
HS042_RS15980	COG4232	protein-disulfide reductase activity
HS042_RS15990	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HS042_RS16005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HS042_RS16015	COG0840	transmembrane signaling receptor activity
HS042_RS16025	COG1509	lysine 2,3-aminomutase activity
HS042_RS16030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HS042_RS16035	COG5510	response to toxic substance
HS042_RS16040	COG5510	response to toxic substance
HS042_RS16050	COG3040	lipid binding
HS042_RS16055	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HS042_RS16060	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HS042_RS16065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HS042_RS16070	COG1053	succinate dehydrogenase
HS042_RS16075	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HS042_RS16080	COG3264	Mechanosensitive ion channel
HS042_RS16080	COG1511	domain protein
HS042_RS16090	COG1162	GTPase activity
HS042_RS16095	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HS042_RS16115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HS042_RS16120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HS042_RS16120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HS042_RS16125	COG0802	atpase or kinase
HS042_RS16130	COG0860	N-Acetylmuramoyl-L-alanine amidase
HS042_RS16135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HS042_RS16140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HS042_RS16150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HS042_RS16155	COG0330	HflC and HflK could
HS042_RS16160	COG0330	HflC and HflK could
HS042_RS16165	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HS042_RS16170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HS042_RS16175	COG1959	2 iron, 2 sulfur cluster binding
HS042_RS16180	COG0557	exoribonuclease II activity
HS042_RS16185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HS042_RS16190	COG1960	acyl-CoA dehydrogenase activity
HS042_RS16195	COG3766	membrane
HS042_RS16205	COG3650	response to hydrogen peroxide
HS042_RS16210	COG1073	alpha beta
HS042_RS16230	COG0360	Binds together with S18 to 16S ribosomal RNA
HS042_RS16240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HS042_RS16245	COG0359	binds to the 23S rRNA
HS042_RS16255	COG3061	Opacity-associated protein A
HS042_RS16260	COG0545	Peptidyl-prolyl cis-trans isomerase
HS042_RS16265	COG0737	Belongs to the 5'-nucleotidase family
HS042_RS16275	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HS042_RS16285	COG1253	flavin adenine dinucleotide binding
HS042_RS16290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HS042_RS16295	COG0729	surface antigen
HS042_RS16300	COG2911	Protein conserved in bacteria
HS042_RS16305	COG2105	PFAM AIG2 family protein
HS042_RS16310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HS042_RS16315	COG0840	transmembrane signaling receptor activity
HS042_RS16320	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HS042_RS16325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HS042_RS16340	COG1438	arginine binding
HS042_RS16345	COG0039	L-malate dehydrogenase activity
HS042_RS16350	COG3423	Transcriptional regulator
HS042_RS16360	COG0142	geranyltranstransferase activity
HS042_RS16365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HS042_RS16370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HS042_RS16375	COG0697	spore germination
HS042_RS16380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HS042_RS16385	COG0642	Histidine kinase
HS042_RS16390	COG0745	RESPONSE REGULATOR receiver
HS042_RS16395	COG2027	D-alanyl-D-alanine carboxypeptidase
HS042_RS16405	COG1534	Rna-binding protein
HS042_RS16410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HS042_RS16420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HS042_RS16425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HS042_RS16430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HS042_RS16445	COG0779	Required for maturation of 30S ribosomal subunits
HS042_RS16450	COG0195	Participates in both transcription termination and antitermination
HS042_RS16455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HS042_RS16460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HS042_RS16465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HS042_RS16470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HS042_RS16475	COG1185	polyribonucleotide nucleotidyltransferase activity
HS042_RS16490	COG0513	Belongs to the DEAD box helicase family
HS042_RS16495	COG2391	methyltransferase activity
HS042_RS16500	COG0425	Belongs to the sulfur carrier protein TusA family
HS042_RS16505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HS042_RS16530	COG0826	peptidase U32
HS042_RS16535	COG0826	peptidase U32
HS042_RS16540	COG3154	lipid carrier protein
HS042_RS16545	COG3153	acetyltransferase
HS042_RS16550	COG2827	Endonuclease containing a URI domain
HS042_RS16560	COG0531	amino acid
HS042_RS16565	COG1982	Orn Lys Arg decarboxylase major
HS042_RS16575	COG3787	Belongs to the UPF0306 family
HS042_RS16580	COG0702	epimerase
HS042_RS16585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HS042_RS16595	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HS042_RS16600	COG3454	Phosphonate metabolism
HS042_RS16605	COG4778	phosphonate C-P lyase system protein PhnL
HS042_RS16610	COG4107	phosphonate C-P lyase system protein PhnK
HS042_RS16615	COG3627	carbon phosphorus lyase activity
HS042_RS16620	COG3626	phosphonate metabolism
HS042_RS16625	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HS042_RS16630	COG3624	Phosphonate C-P lyase system protein PhnG
HS042_RS16635	COG2188	Transcriptional regulator
HS042_RS16640	COG0701	Predicted permease
HS042_RS16675	COG0602	queuosine metabolic process
HS042_RS16685	COG0583	DNA-binding transcription factor activity
HS042_RS16690	COG2249	NAD(P)H dehydrogenase (quinone) activity
HS042_RS16695	COG0366	Alpha amylase catalytic
HS042_RS16700	COG1263	PTS System
HS042_RS16700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS16710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HS042_RS16715	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HS042_RS16735	COG2308	Evidence 4 Homologs of previously reported genes of
HS042_RS16750	COG0540	Belongs to the ATCase OTCase family
HS042_RS16760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HS042_RS16775	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HS042_RS16780	COG0456	acetyltransferase
HS042_RS16790	COG2927	DNA polymerase III (CHI subunit)
HS042_RS16795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HS042_RS16800	COG0795	lipopolysaccharide-transporting ATPase activity
HS042_RS16805	COG0795	lipopolysaccharide-transporting ATPase activity
HS042_RS16810	COG1349	DNA-binding transcription factor activity
HS042_RS16830	COG0738	Major facilitator superfamily
HS042_RS16880	COG2723	6-phospho-beta-galactosidase activity
HS042_RS16885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS16885	COG1263	PTS System
HS042_RS16890	COG1609	Transcriptional regulator
HS042_RS16895	COG1088	dTDP-glucose 4,6-dehydratase activity
HS042_RS16905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HS042_RS16910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HS042_RS16920	COG0523	cobalamin synthesis protein
HS042_RS16925	COG2879	small protein
HS042_RS16930	COG1966	Carbon starvation protein
HS042_RS16940	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HS042_RS16950	COG0174	glutamine synthetase
HS042_RS16980	COG0583	DNA-binding transcription factor activity
HS042_RS16985	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HS042_RS17000	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS042_RS17005	COG2610	gluconate transmembrane transporter activity
HS042_RS17010	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS17020	COG2207	Transcriptional regulator
HS042_RS17030	COG2207	Transcriptional regulator
HS042_RS17030	COG3708	Transcriptional regulator
HS042_RS17040	COG1846	Transcriptional regulator
HS042_RS17045	COG0163	prenyltransferase activity
HS042_RS17050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HS042_RS17060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HS042_RS17085	COG0811	peptide transport
HS042_RS17125	COG1454	alcohol dehydrogenase
HS042_RS17135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS042_RS17145	COG2267	carboxylic ester hydrolase activity
HS042_RS17175	COG1113	amino acid transport
HS042_RS17195	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS17235	COG1846	Transcriptional regulator
HS042_RS17250	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS17255	COG3384	dioxygenase
HS042_RS17265	COG3971	2-oxopent-4-enoate hydratase activity
HS042_RS17285	COG2368	4-hydroxyphenylacetate
HS042_RS17290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HS042_RS17295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HS042_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS17310	COG0179	Fumarylacetoacetate (FAA) hydrolase
HS042_RS17315	COG4948	Mandelate Racemase Muconate Lactonizing
HS042_RS17320	COG3618	amidohydrolase
HS042_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS17330	COG3254	rhamnose metabolic process
HS042_RS17335	COG0738	Major facilitator superfamily
HS042_RS17355	COG1309	transcriptional regulator
HS042_RS17360	COG3706	GGDEF domain
HS042_RS17390	COG0667	Aldo Keto reductase
HS042_RS17395	COG2813	Specifically methylates the guanine in position
HS042_RS17400	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HS042_RS17415	COG3550	peptidyl-serine autophosphorylation
HS042_RS17420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HS042_RS17425	COG2823	Periplasmic or secreted lipoprotein
HS042_RS17430	COG5487	UPF0391 membrane protein
HS042_RS17435	COG3237	CsbD-like
HS042_RS17440	COG4667	esterase of the alpha-beta hydrolase superfamily
HS042_RS17445	COG0084	hydrolase, TatD family'
HS042_RS17450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HS042_RS17455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HS042_RS17465	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HS042_RS17470	COG0813	purine-nucleoside phosphorylase activity
HS042_RS17475	COG3726	membrane protein affecting hemolysin expression
HS042_RS17480	COG0560	Phosphoserine phosphatase
HS042_RS17500	COG0604	alcohol dehydrogenase
HS042_RS17510	COG0488	(ABC) transporter
HS042_RS17515	COG2885	chlorophyll binding
HS042_RS17520	COG2199	diguanylate cyclase activity
HS042_RS17530	COG0741	lytic transglycosylase activity
HS042_RS17535	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HS042_RS17540	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HS042_RS17545	COG0406	alpha-ribazole phosphatase activity
HS042_RS17550	COG2207	Transcriptional regulator
HS042_RS17550	COG3708	Transcriptional regulator
HS042_RS17555	COG3045	CreA protein
HS042_RS17560	COG0745	RESPONSE REGULATOR receiver
HS042_RS17590	COG3022	response to hydroperoxide
HS042_RS17595	COG1115	amino acid carrier protein
HS042_RS17600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HS042_RS17605	COG0521	Mo-molybdopterin cofactor biosynthetic process
HS042_RS17615	COG1584	GPR1 FUN34 yaaH family protein
HS042_RS17620	COG0443	Heat shock 70 kDa protein
HS042_RS17625	COG0484	heat shock protein binding
HS042_RS17630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HS042_RS17635	COG0583	DNA-binding transcription factor activity
HS042_RS17640	COG0268	Binds directly to 16S ribosomal RNA
HS042_RS17645	COG0196	riboflavin kinase activity
HS042_RS17650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HS042_RS17655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HS042_RS17660	COG1047	Peptidyl-prolyl cis-trans
HS042_RS17665	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HS042_RS17690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HS042_RS17695	COG0505	Belongs to the CarA family
HS042_RS17705	COG2249	NAD(P)H dehydrogenase (quinone) activity
HS042_RS17720	COG2966	Psort location CytoplasmicMembrane, score
HS042_RS17730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HS042_RS17740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HS042_RS17745	COG2967	ApaG domain
HS042_RS17750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HS042_RS17755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HS042_RS17765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HS042_RS17775	COG0564	pseudouridine synthase activity
HS042_RS17780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HS042_RS17785	COG0417	DNA replication proofreading
HS042_RS17790	COG0586	Pfam SNARE associated Golgi protein
HS042_RS17795	COG0440	acetolactate synthase activity
HS042_RS17800	COG0028	Belongs to the TPP enzyme family
HS042_RS17815	COG1178	ABC-type Fe3 transport system permease component
HS042_RS17835	COG2814	Major facilitator Superfamily
HS042_RS17840	COG0471	metal ion transport
HS042_RS17845	COG0066	3-isopropylmalate dehydratase activity
HS042_RS17850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HS042_RS17855	COG0473	3-isopropylmalate dehydrogenase activity
HS042_RS17860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HS042_RS17870	COG0583	DNA-binding transcription factor activity
HS042_RS17875	COG1022	Amp-dependent synthetase and ligase
HS042_RS17880	COG0028	Belongs to the TPP enzyme family
HS042_RS17900	COG2001	Belongs to the MraZ family
HS042_RS17905	COG0275	rRNA processing
HS042_RS17910	COG3116	cell division
HS042_RS17915	COG0768	penicillin binding
HS042_RS17920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HS042_RS17925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HS042_RS17930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HS042_RS17940	COG0772	Belongs to the SEDS family
HS042_RS17945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HS042_RS17950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HS042_RS17960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HS042_RS17965	COG0849	cell division
HS042_RS17970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HS042_RS17990	COG0653	protein targeting
HS042_RS17995	COG0494	nUDIX hydrolase
HS042_RS18000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HS042_RS18005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HS042_RS18015	COG0516	GMP reductase activity
HS042_RS18020	COG1459	type II secretion system
HS042_RS18025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HS042_RS18030	COG4969	Belongs to the N-Me-Phe pilin family
HS042_RS18040	COG3023	N-Acetylmuramoyl-L-alanine amidase
HS042_RS18045	COG3725	Membrane protein required for beta-lactamase induction
HS042_RS18050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HS042_RS18060	COG0316	Belongs to the HesB IscA family
HS042_RS18065	COG2860	membrane
HS042_RS18075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HS042_RS18080	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HS042_RS18085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HS042_RS18095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HS042_RS18100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HS042_RS18105	COG3956	TIGRFAM MazG family protein
HS042_RS18110	COG0504	CTP synthase activity
HS042_RS18140	COG2986	histidine ammonia-lyase
HS042_RS18150	COG2271	Major facilitator Superfamily
HS042_RS18155	COG0602	queuosine metabolic process
HS042_RS18160	COG0720	synthase
HS042_RS18165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HS042_RS18170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HS042_RS18175	COG0175	sulfate reduction
HS042_RS18180	COG2234	aminopeptidase activity
HS042_RS18185	COG1648	precorrin-2 dehydrogenase activity
HS042_RS18185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HS042_RS18190	COG0175	sulfate reduction
HS042_RS18195	COG2895	sulfate adenylyltransferase (ATP) activity
HS042_RS18210	COG1126	abc transporter atp-binding protein
HS042_RS18215	COG0765	amino acid transport
HS042_RS18225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HS042_RS18230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HS042_RS18235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HS042_RS18240	COG0585	pseudouridine synthase activity
HS042_RS18245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HS042_RS18250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HS042_RS18255	COG1388	LysM domain
HS042_RS18255	COG4942	peptidase
HS042_RS18260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HS042_RS18265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HS042_RS18275	COG0667	Aldo Keto reductase
HS042_RS18280	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS18285	COG0583	DNA-binding transcription factor activity
HS042_RS18290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HS042_RS18295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HS042_RS18300	COG2723	6-phospho-beta-galactosidase activity
HS042_RS18305	COG1917	Cupin 2, conserved barrel domain protein
HS042_RS18305	COG2169	Transcriptional regulator
HS042_RS18330	COG2137	regulation of response to DNA damage stimulus
HS042_RS18340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HS042_RS18345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HS042_RS18375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HS042_RS18380	COG1238	metal cluster binding
HS042_RS18385	COG2918	glutathione biosynthetic process
HS042_RS18395	COG4536	flavin adenine dinucleotide binding
HS042_RS18400	COG4137	Cytochrome C assembly protein
HS042_RS18405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HS042_RS18410	COG0228	four-way junction DNA binding
HS042_RS18415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HS042_RS18425	COG0335	large ribosomal subunit rRNA binding
HS042_RS18445	COG3137	Salt-induced outer membrane protein
HS042_RS18450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HS042_RS18455	COG1605	Chorismate mutase
HS042_RS18455	COG0287	Prephenate dehydrogenase
HS042_RS18460	COG1605	Chorismate mutase
HS042_RS18460	COG0077	Prephenate dehydratase
HS042_RS18470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HS042_RS18475	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS042_RS18480	COG0564	pseudouridine synthase activity
HS042_RS18490	COG0542	response to heat
HS042_RS18520	COG0656	L-ascorbic acid biosynthetic process
HS042_RS18525	COG0583	DNA-binding transcription factor activity
HS042_RS18530	COG2814	Major facilitator Superfamily
HS042_RS18540	COG1388	LysM domain
HS042_RS18540	COG0741	lytic transglycosylase activity
HS042_RS18545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HS042_RS18550	COG2226	methyltransferase
HS042_RS18555	COG0328	RNA-DNA hybrid ribonuclease activity
HS042_RS18560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HS042_RS18585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HS042_RS18600	COG0436	Aminotransferase
HS042_RS18605	COG0235	Class ii aldolase
HS042_RS18610	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HS042_RS18615	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HS042_RS18620	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HS042_RS18625	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HS042_RS18635	COG1960	acyl-CoA dehydrogenase activity
HS042_RS18640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HS042_RS18645	COG0121	glutamine amidotransferase
HS042_RS18650	COG3034	peptidoglycan biosynthetic process
HS042_RS18655	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HS042_RS18660	COG1805	sodium ion transport
HS042_RS18665	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HS042_RS18670	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HS042_RS18675	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HS042_RS18680	COG2871	sodium ion transport
HS042_RS18685	COG1477	protein flavinylation
HS042_RS18690	COG2991	Protein conserved in bacteria
HS042_RS18705	COG0584	glycerophosphoryl diester phosphodiesterase
HS042_RS18710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HS042_RS18715	COG2195	Cleaves the N-terminal amino acid of tripeptides
HS042_RS18720	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HS042_RS18725	COG1073	alpha beta
HS042_RS18750	COG0582	viral genome integration into host DNA
HS042_RS18760	COG0210	DNA helicase
HS042_RS18805	COG4977	sequence-specific DNA binding
HS042_RS18810	COG0745	RESPONSE REGULATOR receiver
HS042_RS18815	COG5002	protein histidine kinase activity
HS042_RS18820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS042_RS18835	COG3009	Protein conserved in bacteria
HS042_RS18840	COG3008	intermembrane lipid transfer
HS042_RS18840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HS042_RS18845	COG2995	paraquat-inducible protein a
HS042_RS18850	COG2990	Protein conserved in bacteria
HS042_RS18855	COG2819	hydrolase of the alpha beta superfamily
HS042_RS18860	COG2314	TM2 domain
HS042_RS18875	COG1335	isochorismatase
HS042_RS18890	COG2207	Transcriptional regulator
HS042_RS18895	COG1335	isochorismatase
HS042_RS18945	COG3038	cytochrome b561
HS042_RS18950	COG0747	negative chemotaxis
HS042_RS18955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HS042_RS18960	COG1733	regulation of RNA biosynthetic process
HS042_RS18965	COG2249	NAD(P)H dehydrogenase (quinone) activity
HS042_RS18980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HS042_RS18985	COG2207	Transcriptional regulator
HS042_RS18990	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS19000	COG2169	Transcriptional regulator
HS042_RS19000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HS042_RS19020	COG3961	Belongs to the TPP enzyme family
HS042_RS19050	COG1349	DNA-binding transcription factor activity
HS042_RS19055	COG0346	lactoylglutathione lyase activity
HS042_RS19070	COG1335	isochorismatase
HS042_RS19080	COG3011	Protein conserved in bacteria
HS042_RS19090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HS042_RS19095	COG3416	Protein conserved in bacteria
HS042_RS19105	COG2226	methyltransferase
HS042_RS19155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HS042_RS19175	COG1595	DNA-templated transcription, initiation
HS042_RS19225	COG4126	flavin adenine dinucleotide binding
HS042_RS19230	COG3123	guanosine phosphorylase activity
HS042_RS19235	COG2974	May be involved in recombination
HS042_RS19240	COG1940	carbohydrate kinase activity
HS042_RS19260	COG0419	ATPase involved in DNA repair
HS042_RS19265	COG0420	3'-5' exonuclease activity
HS042_RS19270	COG0745	RESPONSE REGULATOR receiver
HS042_RS19275	COG5002	protein histidine kinase activity
HS042_RS19300	COG0668	transmembrane transport
HS042_RS19305	COG0366	Alpha amylase catalytic
HS042_RS19315	COG0450	alkyl hydroperoxide reductase
HS042_RS19320	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HS042_RS19325	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HS042_RS19330	COG0343	queuine tRNA-ribosyltransferase activity
HS042_RS19335	COG1862	Preprotein translocase
HS042_RS19345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HS042_RS19350	COG4238	major outer membrane lipoprotein
HS042_RS19355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HS042_RS19360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HS042_RS19360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HS042_RS19365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HS042_RS19370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HS042_RS19375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HS042_RS19380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HS042_RS19385	COG0667	Aldo Keto reductase
HS042_RS19390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HS042_RS19395	COG0142	geranyltranstransferase activity
HS042_RS19400	COG1722	exodeoxyribonuclease VII activity
HS042_RS19405	COG0301	tRNA thio-modification
HS042_RS19405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HS042_RS19410	COG0693	protein deglycase activity
HS042_RS19415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HS042_RS19420	COG1666	GTP binding
HS042_RS19425	COG2814	Major facilitator Superfamily
HS042_RS19430	COG0109	protoheme IX farnesyltransferase activity
HS042_RS19435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HS042_RS19440	COG1845	cytochrome c oxidase, subunit III
HS042_RS19445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS042_RS19450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HS042_RS19455	COG2223	nitrite transmembrane transporter activity
HS042_RS19460	COG3056	Lipoprotein
HS042_RS19465	COG0271	Belongs to the BolA IbaG family
HS042_RS19470	COG0544	peptidyl-prolyl cis-trans isomerase activity
HS042_RS19480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HS042_RS19485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HS042_RS19495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HS042_RS19500	COG1555	photosystem II stabilization
HS042_RS19505	COG0824	Thioesterase
HS042_RS19510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HS042_RS19515	COG4533	DNA binding
HS042_RS19520	COG0561	phosphatase activity
HS042_RS19530	COG1522	sequence-specific DNA binding
HS042_RS19535	COG1132	(ABC) transporter
HS042_RS19540	COG1132	(ABC) transporter
HS042_RS19545	COG0347	Belongs to the P(II) protein family
HS042_RS19550	COG0004	ammonium transporteR
HS042_RS19555	COG1946	Acyl-CoA thioesterase
HS042_RS19560	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HS042_RS19565	COG3695	enzyme binding
HS042_RS19595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HS042_RS19600	COG0803	Belongs to the bacterial solute-binding protein 9 family
HS042_RS19605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HS042_RS19610	COG0254	rRNA binding
HS042_RS19615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HS042_RS19620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS042_RS19625	COG1309	transcriptional regulator
HS042_RS19630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HS042_RS19635	COG3264	Mechanosensitive ion channel
HS042_RS19635	COG1196	nuclear chromosome segregation
HS042_RS19650	COG2832	Protein of unknown function (DUF454)
HS042_RS19655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HS042_RS19660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HS042_RS19670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HS042_RS19675	COG0326	Molecular chaperone. Has ATPase activity
HS042_RS19680	COG0563	adenylate kinase activity
HS042_RS19685	COG3835	regulator
HS042_RS19690	COG2610	gluconate transmembrane transporter activity
HS042_RS19695	COG1929	Belongs to the glycerate kinase type-1 family
HS042_RS19700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HS042_RS19705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS042_RS19710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HS042_RS19710	COG4651	solute:proton antiporter activity
HS042_RS19715	COG2223	nitrite transmembrane transporter activity
HS042_RS19720	COG0737	Belongs to the 5'-nucleotidase family
HS042_RS19725	COG2027	D-alanyl-D-alanine carboxypeptidase
HS042_RS19730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HS042_RS19735	COG3735	TraB family
HS042_RS19740	COG2217	Heavy metal translocating P-type atpase
HS042_RS19750	COG0778	Nitroreductase
HS042_RS19765	COG3321	synthase
HS042_RS19770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HS042_RS19775	COG0156	8-amino-7-oxononanoate synthase activity
HS042_RS19780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HS042_RS19785	COG1414	Transcriptional regulator
HS042_RS19785	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HS042_RS19805	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HS042_RS19810	COG1960	acyl-CoA dehydrogenase activity
HS042_RS19815	COG0789	Transcriptional regulator
HS042_RS19820	COG1585	Membrane protein implicated in regulation of membrane protease activity
HS042_RS19825	COG0330	HflC and HflK could
HS042_RS19845	COG3960	tartronate-semialdehyde synthase activity
HS042_RS19850	COG3622	Belongs to the hyi family
HS042_RS19855	COG2084	Dehydrogenase
HS042_RS19860	COG2271	Major facilitator Superfamily
HS042_RS19865	COG1929	Belongs to the glycerate kinase type-1 family
HS042_RS19870	COG3257	ureidoglycine aminohydrolase activity
HS042_RS19880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS042_RS19885	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HS042_RS19890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HS042_RS19895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HS042_RS19905	COG0549	Belongs to the carbamate kinase family
HS042_RS19910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HS042_RS19915	COG3118	belongs to the thioredoxin family
HS042_RS19920	COG0300	oxidoreductase activity
HS042_RS19925	COG2755	lipolytic protein G-D-S-L family
HS042_RS19930	COG4181	ATPase activity
HS042_RS19935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HS042_RS19945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HS042_RS19950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HS042_RS19955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HS042_RS19960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HS042_RS19965	COG0215	cysteine-tRNA ligase activity
HS042_RS19970	COG2501	S4 domain
HS042_RS19975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HS042_RS20010	COG0667	Aldo Keto reductase
HS042_RS20025	COG2199	diguanylate cyclase activity
HS042_RS20030	COG1278	Cold shock
HS042_RS20040	COG1126	abc transporter atp-binding protein
HS042_RS20045	COG0765	amino acid transport
HS042_RS20055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS20060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HS042_RS20065	COG1473	amidohydrolase
HS042_RS20075	COG2814	Major facilitator Superfamily
HS042_RS20080	COG1309	transcriptional regulator
HS042_RS20085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HS042_RS20095	COG3706	GGDEF domain
HS042_RS20105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HS042_RS20110	COG0321	lipoyl(octanoyl) transferase activity
HS042_RS20120	COG1686	Belongs to the peptidase S11 family
HS042_RS20125	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HS042_RS20130	COG0772	Belongs to the SEDS family
HS042_RS20135	COG0768	penicillin binding
HS042_RS20140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HS042_RS20145	COG0799	negative regulation of ribosome biogenesis
HS042_RS20150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HS042_RS20155	COG1466	dna polymerase III delta subunit
HS042_RS20160	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HS042_RS20165	COG0495	leucyl-tRNA aminoacylation
HS042_RS20170	COG2888	peptidyl-tyrosine sulfation
HS042_RS20180	COG1957	nucleoside hydrolase
HS042_RS20185	COG1126	abc transporter atp-binding protein
HS042_RS20190	COG0765	amino acid transport
HS042_RS20195	COG0765	amino acid transport
HS042_RS20205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HS042_RS20210	COG4535	Mg2 and Co2 transporter CorC
HS042_RS20215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HS042_RS20220	COG1702	phosphate starvation-inducible protein PhoH
HS042_RS20225	COG2824	Alkylphosphonate utilization operon protein PhnA
HS042_RS20230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HS042_RS20235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HS042_RS20270	COG0367	asparagine synthase
HS042_RS20275	COG3469	chitinase activity
HS042_RS20280	COG0647	UMP catabolic process
HS042_RS20285	COG1940	carbohydrate kinase activity
HS042_RS20285	COG1846	Transcriptional regulator
HS042_RS20290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HS042_RS20295	COG0363	glucosamine-6-phosphate deaminase activity
HS042_RS20300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS20300	COG1263	PTS System
HS042_RS20300	COG2190	(PTS) system
HS042_RS20305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HS042_RS20325	COG0735	belongs to the Fur family
HS042_RS20340	COG0596	Alpha beta hydrolase
HS042_RS20345	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HS042_RS20350	COG0033	Phosphoglucomutase
HS042_RS20355	COG1695	Transcriptional regulator
HS042_RS20365	COG0745	RESPONSE REGULATOR receiver
HS042_RS20370	COG2205	protein histidine kinase activity
HS042_RS20375	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HS042_RS20380	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HS042_RS20385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HS042_RS20400	COG3272	Protein of unknown function (DUF1722)
HS042_RS20410	COG5212	phosphodiesterase
HS042_RS20415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HS042_RS20420	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HS042_RS20425	COG1984	allophanate hydrolase subunit 2
HS042_RS20430	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HS042_RS20450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HS042_RS20465	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HS042_RS20470	COG1053	succinate dehydrogenase
HS042_RS20475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HS042_RS20480	COG0567	Dehydrogenase, E1 component
HS042_RS20485	COG0508	dehydrogenase complex catalyzes the overall conversion of
HS042_RS20490	COG0045	succinate-CoA ligase (ADP-forming) activity
HS042_RS20495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HS042_RS20500	COG0737	Belongs to the 5'-nucleotidase family
HS042_RS20505	COG1271	oxidase subunit
HS042_RS20510	COG1294	oxidase, subunit
HS042_RS20515	COG4890	Cyd operon protein YbgT
HS042_RS20520	COG3790	cyd operon protein YbgE
HS042_RS20525	COG0824	Thioesterase
HS042_RS20530	COG0811	peptide transport
HS042_RS20535	COG0848	biopolymer transport protein
HS042_RS20540	COG3064	Membrane
HS042_RS20545	COG0823	Involved in the tonB-independent uptake of proteins
HS042_RS20550	COG2885	chlorophyll binding
HS042_RS20555	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HS042_RS20610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HS042_RS20620	COG1230	cation diffusion facilitator family transporter
HS042_RS20625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS20625	COG2205	protein histidine kinase activity
HS042_RS20630	COG2197	response regulator
HS042_RS20635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HS042_RS20650	COG0588	phosphoglycerate mutase activity
HS042_RS20660	COG2017	converts alpha-aldose to the beta-anomer
HS042_RS20665	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HS042_RS20670	COG1085	galactose-1-phosphate uridylyltransferase
HS042_RS20685	COG1119	ATPase activity
HS042_RS20690	COG2005	Transcriptional regulator
HS042_RS20690	COG3585	molybdate ion transport
HS042_RS20695	COG4774	siderophore transport
HS042_RS20705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HS042_RS20710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HS042_RS20715	COG1120	ATPase activity
HS042_RS20725	COG0725	ABC transporter, periplasmic molybdate-binding protein
HS042_RS20730	COG4149	molybdate abc transporter
HS042_RS20740	COG0561	phosphatase activity
HS042_RS20750	COG2706	6-phosphogluconolactonase activity
HS042_RS20755	COG1881	PFAM PEBP family protein
HS042_RS20810	COG0556	nucleotide-excision repair
HS042_RS20815	COG4628	conserved protein (DUF2132)
HS042_RS20820	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HS042_RS20825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HS042_RS20830	COG0521	Mo-molybdopterin cofactor biosynthetic process
HS042_RS20835	COG0315	cyclic pyranopterin monophosphate synthase activity
HS042_RS20840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HS042_RS20845	COG0314	molybdopterin synthase activity
HS042_RS20850	COG0670	Belongs to the BI1 family
HS042_RS20855	COG0842	Transport permease protein
HS042_RS20860	COG0842	Transport permease protein
HS042_RS20865	COG1131	(ABC) transporter
HS042_RS20870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS042_RS20875	COG1309	transcriptional regulator
HS042_RS20880	COG0513	Belongs to the DEAD box helicase family
HS042_RS20885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS042_RS20890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HS042_RS20900	COG3842	ATPase activity
HS042_RS20910	COG1840	ABC-type Fe3 transport system, periplasmic component
HS042_RS20915	COG2271	Major facilitator Superfamily
HS042_RS20940	COG0679	Auxin Efflux Carrier
HS042_RS20950	COG0469	pyruvate kinase activity
HS042_RS20955	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS20965	COG0583	DNA-binding transcription factor activity
HS042_RS20985	COG0583	DNA-binding transcription factor activity
HS042_RS20990	COG0586	Pfam SNARE associated Golgi protein
HS042_RS21000	COG4977	sequence-specific DNA binding
HS042_RS21005	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HS042_RS21010	COG1686	Belongs to the peptidase S11 family
HS042_RS21030	COG2354	Protein conserved in bacteria
HS042_RS21045	COG3692	DNA binding
HS042_RS21050	COG1464	Belongs to the NlpA lipoprotein family
HS042_RS21060	COG0456	acetyltransferase
HS042_RS21080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HS042_RS21090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HS042_RS21095	COG0277	FAD linked oxidase domain protein
HS042_RS21110	COG1181	Belongs to the D-alanine--D-alanine ligase family
HS042_RS21120	COG0436	Aminotransferase
HS042_RS21130	COG1472	Belongs to the glycosyl hydrolase 3 family
HS042_RS21155	COG2134	cdp-diacylglycerol pyrophosphatase
HS042_RS21165	COG1192	Involved in chromosome partitioning
HS042_RS21180	COG0583	DNA-binding transcription factor activity
HS042_RS21190	COG1070	Carbohydrate kinase
HS042_RS21195	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HS042_RS21200	COG0697	spore germination
HS042_RS21240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HS042_RS21255	COG1309	transcriptional regulator
HS042_RS21260	COG1464	Belongs to the NlpA lipoprotein family
HS042_RS21265	COG2011	ABC-type metal ion transport system permease component
HS042_RS21270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HS042_RS21275	COG0519	Catalyzes the synthesis of GMP from XMP
HS042_RS21295	COG2084	Dehydrogenase
HS042_RS21310	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HS042_RS21325	COG4807	Protein conserved in bacteria
HS042_RS21345	COG1802	Transcriptional regulator
HS042_RS21365	COG0411	ABC transporter
HS042_RS21405	COG0583	DNA-binding transcription factor activity
HS042_RS21410	COG2897	thiosulfate sulfurtransferase activity
HS042_RS21415	COG0494	nUDIX hydrolase
HS042_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS21435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HS042_RS21445	COG0625	glutathione transferase activity
HS042_RS21455	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HS042_RS21465	COG1335	isochorismatase
HS042_RS21470	COG0583	DNA-binding transcription factor activity
HS042_RS21485	COG1732	Glycine betaine
HS042_RS21490	COG1174	glycine betaine transport
HS042_RS21495	COG1125	glycine betaine transport
HS042_RS21500	COG1174	glycine betaine transport
HS042_RS21515	COG0583	DNA-binding transcription factor activity
HS042_RS21525	COG0697	spore germination
HS042_RS21555	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HS042_RS21570	COG0625	glutathione transferase activity
HS042_RS21580	COG1942	4-Oxalocrotonate Tautomerase
HS042_RS21590	COG1522	sequence-specific DNA binding
HS042_RS21595	COG0697	spore germination
HS042_RS21615	COG2079	MmgE PrpD family protein
HS042_RS21620	COG1280	lysine exporter protein (LysE YggA)
HS042_RS21630	COG0477	Major facilitator Superfamily
HS042_RS21640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HS042_RS21660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HS042_RS21665	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HS042_RS21675	COG1309	transcriptional regulator
HS042_RS21680	COG0456	acetyltransferase
HS042_RS21680	COG1214	PFAM Peptidase M22, glycoprotease
HS042_RS21690	COG0668	transmembrane transport
HS042_RS21695	COG1126	abc transporter atp-binding protein
HS042_RS21700	COG0765	amino acid transport
HS042_RS21705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS21710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HS042_RS21720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HS042_RS21725	COG2731	YhcH YjgK YiaL family protein
HS042_RS21735	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HS042_RS21740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS042_RS21755	COG2610	gluconate transmembrane transporter activity
HS042_RS21760	COG3622	Belongs to the hyi family
HS042_RS21765	COG0235	Class ii aldolase
HS042_RS21770	COG3395	kinase activity
HS042_RS21775	COG2084	Dehydrogenase
HS042_RS21780	COG1349	DNA-binding transcription factor activity
HS042_RS21790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HS042_RS21795	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HS042_RS21815	COG5002	protein histidine kinase activity
HS042_RS21820	COG0745	RESPONSE REGULATOR receiver
HS042_RS21825	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HS042_RS21830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HS042_RS21850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HS042_RS21860	COG1309	transcriptional regulator
HS042_RS21865	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS21870	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HS042_RS21875	COG0069	glutamate synthase activity
HS042_RS21885	COG2200	EAL domain
HS042_RS21895	COG3121	Chaperone
HS042_RS21900	COG3188	usher protein
HS042_RS21910	COG3708	Transcriptional regulator
HS042_RS21910	COG2207	Transcriptional regulator
HS042_RS21915	COG0579	oxidoreductase
HS042_RS21925	COG0625	glutathione transferase activity
HS042_RS21930	COG0640	Transcriptional regulator
HS042_RS21940	COG1335	isochorismatase
HS042_RS21945	COG0583	DNA-binding transcription factor activity
HS042_RS21955	COG3811	Belongs to the UPF0386 family
HS042_RS21960	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HS042_RS21970	COG0583	DNA-binding transcription factor activity
HS042_RS21990	COG0488	(ABC) transporter
HS042_RS22005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HS042_RS22015	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HS042_RS22015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS042_RS22040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HS042_RS22045	COG0303	'Molybdopterin
HS042_RS22060	COG4172	Belongs to the ABC transporter superfamily
HS042_RS22065	COG0747	negative chemotaxis
HS042_RS22070	COG0601	transmembrane transport
HS042_RS22075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HS042_RS22100	COG0583	DNA-binding transcription factor activity
HS042_RS22105	COG0477	Major facilitator Superfamily
HS042_RS22110	COG0302	gtp cyclohydrolase
HS042_RS22115	COG2311	Membrane
HS042_RS22140	COG2949	membrane
HS042_RS22145	COG0281	malic enzyme
HS042_RS22150	COG0295	cytidine deaminase activity
HS042_RS22155	COG1346	cytolysis
HS042_RS22160	COG1380	Effector of murein hydrolase LrgA
HS042_RS22165	COG2814	Major facilitator Superfamily
HS042_RS22175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS042_RS22175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS042_RS22180	COG0489	protein tyrosine kinase activity
HS042_RS22190	COG0572	uridine kinase
HS042_RS22195	COG0717	Belongs to the dCTP deaminase family
HS042_RS22200	COG2982	Protein involved in outer membrane biogenesis
HS042_RS22205	COG3069	C4-dicarboxylate transmembrane transporter activity
HS042_RS22210	COG1253	flavin adenine dinucleotide binding
HS042_RS22215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HS042_RS22220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HS042_RS22235	COG3206	protein involved in exopolysaccharide biosynthesis
HS042_RS22235	COG0489	protein tyrosine kinase activity
HS042_RS22295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HS042_RS22325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HS042_RS22335	COG0438	transferase activity, transferring glycosyl groups
HS042_RS22350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HS042_RS22350	COG0140	phosphoribosyl-ATP diphosphatase activity
HS042_RS22355	COG0107	imidazoleglycerol-phosphate synthase activity
HS042_RS22360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HS042_RS22370	COG0131	Imidazoleglycerol-phosphate dehydratase
HS042_RS22370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HS042_RS22375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HS042_RS22380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HS042_RS22385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HS042_RS22395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HS042_RS22410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HS042_RS22415	COG3153	acetyltransferase
HS042_RS22415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS042_RS22420	COG0598	Magnesium transport protein CorA
HS042_RS22430	COG2133	pyrroloquinoline quinone binding
HS042_RS22435	COG0625	glutathione transferase activity
HS042_RS22455	COG0626	cystathionine gamma-synthase activity
HS042_RS22465	COG1686	Belongs to the peptidase S11 family
HS042_RS22490	COG3539	Fimbrial protein
HS042_RS22495	COG3188	usher protein
HS042_RS22500	COG3121	Chaperone
HS042_RS22520	COG0545	Peptidyl-prolyl cis-trans isomerase
HS042_RS22525	COG2197	response regulator
HS042_RS22530	COG1760	l-serine dehydratase
HS042_RS22535	COG0814	amino acid
HS042_RS22540	COG1349	DNA-binding transcription factor activity
HS042_RS22545	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HS042_RS22555	COG0671	phosphoesterase, PA-phosphatase related
HS042_RS22565	COG4574	serine-type endopeptidase inhibitor activity
HS042_RS22575	COG0569	domain protein
HS042_RS22575	COG2985	domain, Protein
HS042_RS22595	COG0189	ligase activity
HS042_RS22605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HS042_RS22610	COG3842	ATPase activity
HS042_RS22615	COG1176	ABC-type spermidine putrescine transport system, permease component I
HS042_RS22620	COG1177	transmembrane transport
HS042_RS22630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HS042_RS22635	COG2026	Addiction module toxin, RelE StbE family
HS042_RS22645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS22650	COG4160	amino acid transport
HS042_RS22655	COG4215	(ABC) transporter
HS042_RS22660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HS042_RS22665	COG1126	abc transporter atp-binding protein
HS042_RS22675	COG0393	Putative heavy-metal-binding
HS042_RS22685	COG3023	N-Acetylmuramoyl-L-alanine amidase
HS042_RS22690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HS042_RS22695	COG0702	epimerase
HS042_RS22705	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HS042_RS22710	COG0028	Belongs to the TPP enzyme family
HS042_RS22715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HS042_RS22720	COG1151	hydroxylamine reductase activity
HS042_RS22725	COG2431	L-lysine efflux transmembrane transporter activity
HS042_RS22730	COG3593	DNA synthesis involved in DNA repair
HS042_RS22735	COG2990	Protein conserved in bacteria
HS042_RS22740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS042_RS22750	COG1278	Cold shock
HS042_RS22755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HS042_RS22760	COG0542	response to heat
HS042_RS22765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HS042_RS22770	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HS042_RS22775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HS042_RS22785	COG0492	ferredoxin-NADP+ reductase activity
HS042_RS22795	COG1674	ftsk spoiiie
HS042_RS22795	COG3107	peptidoglycan biosynthetic process
HS042_RS22800	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HS042_RS22805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HS042_RS22810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HS042_RS22820	COG2814	Major facilitator Superfamily
HS042_RS22825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HS042_RS22830	COG1882	Formate acetyltransferase
HS042_RS22835	COG2116	formate transmembrane transporter activity
HS042_RS22840	COG1944	ATP diphosphatase activity
HS042_RS22845	COG0252	asparaginase activity
HS042_RS22850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HS042_RS22855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HS042_RS22860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HS042_RS22865	COG0539	negative regulation of cytoplasmic translation
HS042_RS22875	COG2333	competence protein COMEC
HS042_RS22875	COG0658	competence protein
HS042_RS22880	COG1132	(ABC) transporter
HS042_RS22885	COG1663	tetraacyldisaccharide 4'-kinase activity
HS042_RS22890	COG5383	Protein conserved in bacteria
HS042_RS22900	COG1278	Cold shock
HS042_RS22905	COG3214	Protein conserved in bacteria
HS042_RS22910	COG2835	tetraacyldisaccharide 4'-kinase activity
HS042_RS22915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HS042_RS22920	COG3173	Aminoglycoside phosphotransferase
HS042_RS22925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HS042_RS22930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HS042_RS22935	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HS042_RS22945	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HS042_RS22950	COG2989	Protein conserved in bacteria
HS042_RS22955	COG3108	Peptidase M15
HS042_RS22960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HS042_RS22965	COG1448	Aminotransferase
HS042_RS22975	COG0017	Asparaginyl-tRNA synthetase
HS042_RS22980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HS042_RS22985	COG3706	GGDEF domain
HS042_RS22990	COG0308	aminopeptidase N
HS042_RS23000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HS042_RS23005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HS042_RS23010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HS042_RS23015	COG0431	NADPH-dependent FMN reductase
HS042_RS23020	COG0167	dihydroorotate dehydrogenase activity
HS042_RS23030	COG0633	Ferredoxin
HS042_RS23030	COG3217	Mosc domain protein beta barrel domain protein
HS042_RS23035	COG0116	Belongs to the methyltransferase superfamily
HS042_RS23035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HS042_RS23040	COG0488	(ABC) transporter
HS042_RS23045	COG2995	paraquat-inducible protein a
HS042_RS23050	COG3008	intermembrane lipid transfer
HS042_RS23050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HS042_RS23055	COG3009	Protein conserved in bacteria
HS042_RS23060	COG3130	regulation of translation
HS042_RS23065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HS042_RS23075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HS042_RS23080	COG1067	ATP-dependent peptidase activity
HS042_RS23100	COG3070	regulator of competence-specific genes
HS042_RS23105	COG1289	transmembrane transporter activity
HS042_RS23110	COG3304	Inner membrane component domain
HS042_RS23115	COG0210	DNA helicase
HS042_RS23120	COG1803	Methylglyoxal synthase
HS042_RS23130	COG1832	CoA-binding protein
HS042_RS23135	COG3785	DNA binding
HS042_RS23140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HS042_RS23145	COG1254	Belongs to the acylphosphatase family
HS042_RS23150	COG2920	part of a sulfur-relay system
HS042_RS23155	COG0670	Belongs to the BI1 family
HS042_RS23175	COG3121	Chaperone
HS042_RS23180	COG3188	usher protein
HS042_RS23200	COG0789	Transcriptional regulator
HS042_RS23205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS042_RS23210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HS042_RS23225	COG0655	NAD(P)H dehydrogenase (quinone) activity
HS042_RS23230	COG1280	lysine exporter protein (LysE YggA)
HS042_RS23255	COG1113	amino acid transport
HS042_RS23270	COG2271	Major facilitator Superfamily
HS042_RS23295	COG2814	Major facilitator Superfamily
HS042_RS23300	COG0156	8-amino-7-oxononanoate synthase activity
HS042_RS23305	COG0183	Belongs to the thiolase family
HS042_RS23310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS042_RS23315	COG2197	response regulator
HS042_RS23320	COG0589	response to stress
HS042_RS23335	COG0531	amino acid
HS042_RS23340	COG1012	belongs to the aldehyde dehydrogenase family
HS042_RS23345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HS042_RS23375	COG0446	pyridine nucleotide-disulphide oxidoreductase
HS042_RS23395	COG3136	membrane protein required for alginate biosynthesis
HS042_RS23405	COG2197	response regulator
HS042_RS23410	COG0322	excinuclease ABC activity
HS042_RS23435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HS042_RS23470	COG1538	Outer membrane efflux protein
HS042_RS23480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS042_RS23485	COG0322	excinuclease ABC activity
HS042_RS23520	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HS042_RS23525	COG2943	transferase activity, transferring hexosyl groups
HS042_RS23530	COG5645	(Lipo)protein
HS042_RS23545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HS042_RS23555	COG0640	Transcriptional regulator
HS042_RS23580	COG2814	Major facilitator Superfamily
HS042_RS23590	COG1560	Kdo2-lipid A biosynthetic process
HS042_RS23600	COG1054	Belongs to the UPF0176 family
HS042_RS23605	COG2353	YceI-like domain
HS042_RS23610	COG3038	cytochrome b561
HS042_RS23615	COG0628	permease
HS042_RS23655	COG0418	dihydroorotase activity
HS042_RS23660	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HS042_RS23665	COG1530	ribonuclease E activity
HS042_RS23670	COG0564	pseudouridine synthase activity
HS042_RS23680	COG1399	metal-binding, possibly nucleic acid-binding protein
HS042_RS23685	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HS042_RS23690	COG0416	fatty acid biosynthetic process
HS042_RS23695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HS042_RS23700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HS042_RS23710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HS042_RS23715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HS042_RS23720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HS042_RS23725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HS042_RS23730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS042_RS23735	COG0470	DNA polymerase III
HS042_RS23740	COG0084	hydrolase, TatD family'
HS042_RS23745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS23745	COG1263	PTS System
HS042_RS23755	COG1321	iron dependent repressor
HS042_RS23760	COG1914	H( )-stimulated, divalent metal cation uptake system
HS042_RS23765	COG1028	Short-chain dehydrogenase reductase Sdr
HS042_RS23770	COG1733	regulation of RNA biosynthetic process
HS042_RS23775	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HS042_RS23780	COG0537	adenosine 5'-monophosphoramidase activity
HS042_RS23785	COG5633	Lipoprotein
HS042_RS23790	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HS042_RS23795	COG0510	thiamine kinase activity
HS042_RS23805	COG3150	esterase
HS042_RS23810	COG1252	NADH dehydrogenase
HS042_RS23815	COG3134	Outer membrane lipoprotein
HS042_RS23830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HS042_RS23835	COG2207	Transcriptional regulator
HS042_RS23835	COG3708	Transcriptional regulator
HS042_RS23860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HS042_RS23865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HS042_RS23870	COG3381	protein complex oligomerization
HS042_RS23875	COG2979	Protein of unknown function (DUF533)
HS042_RS23880	COG1770	oligopeptidase
HS042_RS23885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HS042_RS23900	COG0583	DNA-binding transcription factor activity
HS042_RS23920	COG1528	Iron-storage protein
HS042_RS23925	COG2372	response to copper ion
HS042_RS23930	COG1276	copper resistance
HS042_RS23960	COG2246	polysaccharide biosynthetic process
HS042_RS23965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HS042_RS24005	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HS042_RS24025	COG4565	transcriptional regulatory protein
HS042_RS24030	COG3290	protein histidine kinase activity
HS042_RS24045	COG1129	ABC transporter
HS042_RS24050	COG1172	Belongs to the binding-protein-dependent transport system permease family
HS042_RS24065	COG1464	Belongs to the NlpA lipoprotein family
HS042_RS24075	COG0589	response to stress
HS042_RS24080	COG3408	Glycogen debranching enzyme
HS042_RS24080	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HS042_RS24090	COG1609	Transcriptional regulator
HS042_RS24095	COG3250	beta-galactosidase activity
HS042_RS24100	COG2731	YhcH YjgK YiaL family protein
HS042_RS24105	COG0531	amino acid
HS042_RS24110	COG0640	Transcriptional regulator
HS042_RS24120	COG0740	serine-type endopeptidase activity
HS042_RS24145	COG3121	Chaperone
HS042_RS24180	COG0012	GTP binding
HS042_RS24185	COG0659	secondary active sulfate transmembrane transporter activity
HS042_RS24190	COG0193	aminoacyl-tRNA hydrolase activity
HS042_RS24200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HS042_RS24205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HS042_RS24210	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HS042_RS24215	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HS042_RS24220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HS042_RS24225	COG2890	protein-(glutamine-N5) methyltransferase activity
HS042_RS24230	COG3094	Invasion gene expression up-regulator, SirB
HS042_RS24235	COG2912	Transglutaminase-like superfamily
HS042_RS24240	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HS042_RS24245	COG0659	secondary active sulfate transmembrane transporter activity
HS042_RS24250	COG4702	Belongs to the UPF0303 family
HS042_RS24255	COG3706	GGDEF domain
HS042_RS24260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HS042_RS24265	COG4591	ABC-type transport system involved in lipoprotein release permease component
HS042_RS24275	COG4591	ABC-type transport system involved in lipoprotein release permease component
HS042_RS24305	COG1486	melibiose metabolic process
HS042_RS24310	COG1263	PTS System
HS042_RS24310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HS042_RS24315	COG1177	transmembrane transport
HS042_RS24335	COG2195	Cleaves the N-terminal amino acid of tripeptides
HS042_RS24340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HS042_RS24345	COG2850	peptidyl-arginine hydroxylation
HS042_RS24355	COG0745	RESPONSE REGULATOR receiver
HS042_RS24360	COG1397	ADP-ribosylglycohydrolase
HS042_RS24365	COG2188	Transcriptional regulator
HS042_RS24380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HS042_RS24385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HS042_RS24390	COG2915	High frequency lysogenization protein hflD homolog
HS042_RS24400	COG0482	sulfurtransferase activity
HS042_RS24415	COG1187	pseudouridine synthase activity
HS042_RS24420	COG0538	isocitrate dehydrogenase activity
HS042_RS24425	COG0582	viral genome integration into host DNA
HS042_RS24475	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HS042_RS24480	COG5532	Uncharacterized conserved protein (DUF2303)
HS042_RS24515	COG4197	protein conserved in bacteria, prophage-related