locus-tag class description F0335_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) F0335_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F0335_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) F0335_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0335_RS00025 ENOG410667J hydrolase F0335_RS00045 ENOG4105D99 atp gtp-binding protein F0335_RS00050 ENOG4105R2A (LipO)protein F0335_RS00055 ENOG4108ZNX Heat shock protein F0335_RS00060 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) F0335_RS00065 ENOG4105D0C transport protein F0335_RS00075 ENOG41068KX affects formate dehydrogenase-N F0335_RS00080 ENOG4105JKW Valine--pyruvate aminotransferase F0335_RS00085 ENOG4107T9C Alpha amylase catalytic region F0335_RS00095 ENOG4105C5I Dehydrogenase F0335_RS00100 ENOG4105JHE Major Facilitator Superfamily F0335_RS00105 ENOG4105D7K pfkb domain protein F0335_RS00115 ENOG4108M60 Transcriptional regulator F0335_RS00120 ENOG4108ZG0 Ompa motb domain protein F0335_RS00130 ENOG4108R3E Dna-3-methyladenine glycosylase i F0335_RS00150 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit F0335_RS00155 ENOG4105C38 Glycyl-tRNA synthetase beta subunit F0335_RS00160 ENOG4106JH6 (LipO)protein F0335_RS00170 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase F0335_RS00175 ENOG4105E61 Mannitol repressor protein F0335_RS00185 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0335_RS00190 ENOG4108YYI Protein of unknown function (DUF2810) F0335_RS00200 ENOG4108RPX mosc domain containing protein F0335_RS00205 ENOG4105C8Q Methyl-accepting chemotaxis F0335_RS00210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0335_RS00220 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein F0335_RS00225 ENOG4108MG3 formate dehydrogenase F0335_RS00230 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) F0335_RS00240 ENOG4108U78 Glutathione S-transferase F0335_RS00245 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) F0335_RS00250 ENOG4105EM7 Selenocysteine-specific translation elongation factor F0335_RS00270 ENOG4105MEV Acyl-transferase F0335_RS00280 ENOG4108RWI nicotinamidase F0335_RS00285 ENOG4105DZC cytosine deaminase F0335_RS00290 ENOG4107NQ8 LysR family Transcriptional regulator F0335_RS00295 ENOG4105DJ2 Major Facilitator Superfamily F0335_RS00355 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F0335_RS00380 ENOG4105F27 Major Facilitator F0335_RS00395 ENOG4105CHR reductase F0335_RS00410 ENOG4105TW1 Carbohydrate-selective porin OprB F0335_RS00420 ENOG4105K56 Transcriptional regulator F0335_RS00425 ENOG4108ZHJ Organic hydroperoxide resistance protein F0335_RS00430 ENOG4105DIJ Phosphoethanolamine transferase F0335_RS00435 ENOG4108KX4 response regulator F0335_RS00440 ENOG4105BZU Histidine kinase F0335_RS00445 ENOG4105CXY transporter F0335_RS00470 ENOG4105DEF Extracellular solute-binding protein, family 5 F0335_RS00475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F0335_RS00480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F0335_RS00485 ENOG4105C3U ABC transporter F0335_RS00490 ENOG4108JQ7 (ABC) transporter F0335_RS00495 ENOG4105D1V cellulose synthase operon protein YhjU F0335_RS00500 ENOG4105WQA Cellulose biosynthesis protein BcsF F0335_RS00505 ENOG4105U74 cellulose biosynthesis protein BcsE F0335_RS00520 ENOG4107QZ7 Cellulose synthase catalytic subunit F0335_RS00525 ENOG4107EEX Cellulose synthase regulator protein F0335_RS00530 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) F0335_RS00535 ENOG4105EJG cellulose synthase F0335_RS00540 ENOG4105BZU Histidine kinase F0335_RS00545 ENOG4105CK2 sodium dicarboxylate symporter F0335_RS00550 ENOG4105CS0 peptidase F0335_RS00555 ENOG4105KQ5 peptidylprolyl cis-trans isomerase F0335_RS00560 ENOG4105C4R Atp-dependent dna helicase F0335_RS00565 ENOG4105C9X ppx gppa phosphatase F0335_RS00570 ENOG4105C1J atp-dependent rna helicase F0335_RS00580 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) F0335_RS00585 ENOG4105ESV Glycosyl transferase, family 4 F0335_RS00590 ENOG4105SFE lipopolysaccharide biosynthesis protein F0335_RS00595 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F0335_RS00600 ENOG4108IJ1 Dehydrogenase F0335_RS00605 ENOG4105C1B dTDP-glucose 4-6-dehydratase F0335_RS00610 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) F0335_RS00615 ENOG4108WJ1 acetyltransferase F0335_RS00620 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase F0335_RS00625 ENOG4105EGZ biosynthesis protein F0335_RS00630 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) F0335_RS00635 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) F0335_RS00640 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family F0335_RS00645 ENOG4105C85 amino acid F0335_RS00675 ENOG410601J HemY protein F0335_RS00680 ENOG4105ECF c-methyltransferase F0335_RS00685 ENOG41076E6 Uroporphyrinogen-III Synthase F0335_RS00690 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) F0335_RS00700 ENOG4105XQ6 frataxin-like protein F0335_RS00705 ENOG4105S7Z (LipO)protein F0335_RS00710 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) F0335_RS00715 ENOG4105CT0 Protein of unknown function, DUF484 F0335_RS00725 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant F0335_RS00730 ENOG4105C4R Atp-dependent dna helicase F0335_RS00745 ENOG4105FR1 rard protein F0335_RS00750 ENOG4108VUY thioesterase Superfamily protein F0335_RS00755 ENOG4105HDD phospholipase F0335_RS00760 ENOG4105C9U ATP-dependent DNA helicase RecQ F0335_RS00765 ENOG4105CCF Lysine exporter protein (Lyse ygga) F0335_RS00770 ENOG410829K Lysine exporter protein (Lyse ygga) F0335_RS00775 ENOG4108EUD Lysophospholipase F0335_RS00780 ENOG4105DQF Hydrolase F0335_RS00785 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase F0335_RS00790 ENOG4105CXY transporter F0335_RS00795 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A F0335_RS00805 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F0335_RS00810 ENOG4108W1V Lipoprotein F0335_RS00820 ENOG4105EX9 Membrane F0335_RS00825 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) F0335_RS00830 ENOG4105C59 p-type ATPase F0335_RS00845 ENOG4107FS9 Membrane F0335_RS00855 ENOG4105MG3 Membrane F0335_RS00860 ENOG4106H78 methyltransferase F0335_RS00865 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F0335_RS00865 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F0335_RS00870 ENOG4105CAK Cell division ATP-binding protein ftsE F0335_RS00875 ENOG4105CRP Part of the ABC transporter FtsEX involved in F0335_RS00895 ENOG4105U59 -acetyltransferase F0335_RS00905 ENOG4105C32 Amino acid ABC transporter (Permease) F0335_RS00910 ENOG4105CF8 branched-chain amino acid ABC transporter, permease F0335_RS00915 ENOG4105C0Z ABC transporter F0335_RS00920 ENOG4108IV0 ABC, transporter F0335_RS00925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0335_RS00930 ENOG4105BZ7 extracellular solute-binding protein family 1 F0335_RS00935 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component F0335_RS00945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0335_RS00950 ENOG4107T6V glycerophosphoryl diester phosphodiesterase F0335_RS00965 ENOG4105EMK carboxylate amino acid amine transporter F0335_RS00970 ENOG4105DZ2 Transcriptional regulator F0335_RS00975 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) F0335_RS00980 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) F0335_RS00985 ENOG4107SXA Phosphorylase F0335_RS00995 ENOG4108KF1 Membrane F0335_RS01000 ENOG4105CGY Dna recombination protein F0335_RS01005 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F0335_RS01010 ENOG4105JC1 sterol-binding domain protein F0335_RS01015 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) F0335_RS01020 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) F0335_RS01030 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) F0335_RS01035 ENOG4105F8V Hydrolase, tatD family F0335_RS01040 ENOG4105D52 delta-aminolevulinic acid dehydratase F0335_RS01045 ENOG4105MDZ Transcriptional activator rfaH F0335_RS01060 ENOG4107QK7 reductase F0335_RS01065 ENOG4105CHU acetyl-coa acetyltransferase F0335_RS01070 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F0335_RS01080 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) F0335_RS01085 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein F0335_RS01090 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) F0335_RS01095 ENOG4108RR8 protoporphyrinogen oxidase F0335_RS01120 ENOG4105D4A Cell wall formation (By similarity) F0335_RS01125 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase F0335_RS01130 ENOG4105CS9 pantothenic acid kinase F0335_RS01165 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) F0335_RS01170 ENOG4105PM1 preprotein translocase subunit SecE F0335_RS01175 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F0335_RS01190 ENOG4108VZM 50s ribosomal protein L10 F0335_RS01200 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F0335_RS01205 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F0335_RS01230 ENOG4105D41 biosynthesis protein thiH F0335_RS01235 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) F0335_RS01240 ENOG4105WHD thiamine biosynthesis protein ThiS F0335_RS01245 ENOG4105D06 uba thif-type nad fad binding protein F0335_RS01250 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) F0335_RS01255 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) F0335_RS01260 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor F0335_RS01265 ENOG4105E09 nadh pyrophosphatase F0335_RS01270 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) F0335_RS01275 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) F0335_RS01280 ENOG4105R2J Conserved Protein F0335_RS01290 ENOG4108T8B Protein of unknown function (DUF1481) F0335_RS01295 ENOG4105C12 Phosphoribosylglycinamide synthetase F0335_RS01300 ENOG4105DC1 bifunctional purine biosynthesis protein purh F0335_RS01330 ENOG4107QN1 sodium solute F0335_RS01335 ENOG41062QD Membrane F0335_RS01340 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F0335_RS01345 ENOG4105CK2 sodium dicarboxylate symporter F0335_RS01350 ENOG4105C0W non-ribosomal peptide synthetase F0335_RS01360 ENOG4105C0W non-ribosomal peptide synthetase F0335_RS01365 ENOG4107RBR Receptor F0335_RS01370 ENOG4105CEY Amp-dependent synthetase and ligase F0335_RS01375 ENOG4108NS2 receptor F0335_RS01380 ENOG4107RNH Outer membrane receptor FepA F0335_RS01385 ENOG4105E93 esterase F0335_RS01395 ENOG4105C0W non-ribosomal peptide synthetase F0335_RS01405 ENOG4105E4F Isochorismate synthase F0335_RS01410 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F0335_RS01415 ENOG4105WQI isochorismatase F0335_RS01420 ENOG4108NS2 receptor F0335_RS01425 ENOG4108R5S membrane F0335_RS01455 ENOG4106PG1 outer membrane usher protein F0335_RS01465 ENOG4108FZ9 Chaperone F0335_RS01475 ENOG4105UGQ Fimbrial F0335_RS01520 ENOG4108SIC Transcriptional regulator F0335_RS01525 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) F0335_RS01550 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) F0335_RS01560 ENOG4108ZVF (LipO)protein F0335_RS01565 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein F0335_RS01570 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) F0335_RS01575 ENOG4107PEH Entericidin EcnA/B family F0335_RS01580 ENOG4106BSU Entericidin B F0335_RS01590 ENOG4105QNF Outer membrane lipoprotein F0335_RS01595 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) F0335_RS01600 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) F0335_RS01615 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) F0335_RS01625 ENOG4105DJ4 phosphatidylserine decarboxylase F0335_RS01630 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) F0335_RS01635 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) F0335_RS01655 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) F0335_RS01660 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) F0335_RS01665 ENOG4105K8N protein family UPF0079, ATPase F0335_RS01670 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F0335_RS01675 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) F0335_RS01680 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) F0335_RS01690 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F0335_RS01695 ENOG4107QJR hflk protein F0335_RS01700 ENOG4105EPW hflc protein F0335_RS01710 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis F0335_RS01715 ENOG4105KPV Transcriptional regulator F0335_RS01720 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) F0335_RS01725 ENOG4105C2N RNA methyltransferase TrmH family group 3 F0335_RS01730 ENOG4105CSU acyl-Coa dehydrogenase F0335_RS01735 ENOG4105Z6B inner membrane protein yjfl F0335_RS01745 ENOG4105WSB biofilm stress and motility protein A F0335_RS01750 ENOG4108MXZ Esterase F0335_RS01765 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) F0335_RS01775 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) F0335_RS01780 ENOG4105K9Q Binds to the 23S rRNA (By similarity) F0335_RS01790 ENOG4105FHY Opacity-associated protein A F0335_RS01795 ENOG4108V1T peptidylprolyl cis-trans isomerase F0335_RS01805 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic F0335_RS01810 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase F0335_RS01815 ENOG4108UUE Transcriptional regulator F0335_RS01820 ENOG41061GZ Protein of unknown function (DUF1107) F0335_RS01825 ENOG4105C37 (CBS) domain F0335_RS01830 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) F0335_RS01835 ENOG4105CFU surface antigen F0335_RS01840 ENOG4105MA0 exported protein F0335_RS01845 ENOG4108ZHD aig2 family F0335_RS01850 ENOG4105F0N pyrophosphate phospho-hydrolase F0335_RS01855 ENOG4105C8Q Methyl-accepting chemotaxis F0335_RS01860 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 F0335_RS01880 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) F0335_RS01885 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F0335_RS01890 ENOG4105HVQ Regulatory factor of maltose metabolism F0335_RS01900 ENOG4105EAH synthase F0335_RS01905 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) F0335_RS01910 ENOG4105K46 50S ribosomal protein l27 F0335_RS01920 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control F0335_RS01935 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase F0335_RS01940 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) F0335_RS01945 ENOG4105HBR Rna-binding protein F0335_RS01950 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) F0335_RS01955 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) F0335_RS01960 ENOG4105EEI dihydropteroate synthase F0335_RS01965 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) F0335_RS01970 ENOG4105NTZ Preprotein translocase subunit SecG F0335_RS01985 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) F0335_RS01990 ENOG4105CHV Transcription elongation factor NusA F0335_RS01995 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) F0335_RS02000 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) F0335_RS02005 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) F0335_RS02010 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) F0335_RS02015 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) F0335_RS02030 ENOG4105C1J atp-dependent rna helicase F0335_RS02035 ENOG41066VF YeeE YedE family protein F0335_RS02045 ENOG4105DEN Luciferase family F0335_RS02080 ENOG4108YYD acetyltransferase F0335_RS02085 ENOG41082IR Excinuclease ABC C subunit domain protein F0335_RS02090 ENOG4105D5Q Arginine ornithine antiporter F0335_RS02095 ENOG4105CXN decarboxylase F0335_RS02105 ENOG4108ZPB UPF0306 protein F0335_RS02110 ENOG41069ZX F0335_RS02115 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) F0335_RS02120 ENOG4105K4T epimerase F0335_RS02125 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein F0335_RS02135 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) F0335_RS02140 ENOG4105FD8 phosphonate metabolism protein PhnM F0335_RS02145 ENOG4105HRV phosphonate c-p lyase system protein phnl F0335_RS02150 ENOG4105ENV phosphonate C-P lyase system protein PhnK F0335_RS02155 ENOG4105FT8 Phosphonate metabolism F0335_RS02160 ENOG4105EKV Phosphonate metabolism protein F0335_RS02165 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH F0335_RS02170 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG F0335_RS02175 ENOG4107RJJ Transcriptional regulator F0335_RS02180 ENOG4107S21 permease F0335_RS02195 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) F0335_RS02200 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase F0335_RS02205 ENOG410642W LysR family Transcriptional regulator F0335_RS02210 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein F0335_RS02215 ENOG4105CG3 alpha amylase, catalytic region F0335_RS02220 ENOG4105C5Y PTS System F0335_RS02225 ENOG4105D4X repressor F0335_RS02230 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic F0335_RS02245 ENOG4105KME endoribonuclease L-psp F0335_RS02250 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) F0335_RS02255 ENOG4105CXT aspartate transcarbamylase F0335_RS02265 ENOG4105DBV ornithine carbamoyltransferase F0335_RS02270 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) F0335_RS02275 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase F0335_RS02280 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) F0335_RS02285 ENOG4108MJ3 acetyltransferase F0335_RS02295 ENOG4105MYG DNA polymerase iii, chi subunit F0335_RS02300 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) F0335_RS02305 ENOG4108M8S permease YjgP YjgQ family protein F0335_RS02310 ENOG4108K5H permease YjgP YjgQ family protein F0335_RS02345 ENOG4105ZTC transcriptional activator, Ogr delta F0335_RS02415 ENOG4105DZR Type I site-specific deoxyribonuclease F0335_RS02440 ENOG4106H3A restriction F0335_RS02465 ENOG4105CS2 ec 3.2.1.21 F0335_RS02470 ENOG4105C5Y PTS System F0335_RS02475 ENOG4105DDV Transcriptional regulator (LacI family F0335_RS02485 ENOG4105CKI cobalamin synthesis protein F0335_RS02490 ENOG4105VCD cytoplasmic protein F0335_RS02495 ENOG4105D22 carbon starvation protein F0335_RS02500 ENOG4105DDW LysR family Transcriptional regulator F0335_RS02530 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase F0335_RS02540 ENOG4105CFQ glutamine synthetase F0335_RS02585 ENOG4106NZI LysR family Transcriptional regulator F0335_RS02590 ENOG4105D6N CoA-transferase, subunit a F0335_RS02600 ENOG4105CHU acetyl-coa acetyltransferase F0335_RS02605 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) F0335_RS02610 ENOG4105CY2 Citrate transporter F0335_RS02615 ENOG4105DTD Dehydrogenase F0335_RS02630 ENOG4105R1U AraC Family Transcriptional Regulator F0335_RS02640 ENOG4105UEI Transcriptional Regulator AraC Family F0335_RS02645 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F0335_RS02660 ENOG4105M8F Biopolymer transport protein exbD tolR F0335_RS02700 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F0335_RS02705 ENOG4105EVZ LysR family transcriptional regulator F0335_RS02710 ENOG4105C0A alcohol dehydrogenase F0335_RS02715 ENOG4108UDW Transcriptional regulator, luxr family F0335_RS02720 ENOG4105CJP fad dependent oxidoreductase F0335_RS02730 ENOG410832A alpha/beta hydrolase fold F0335_RS02735 ENOG4105DGU Histone deacetylase F0335_RS02745 ENOG4108UAJ Transcriptional regulator F0335_RS02750 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) F0335_RS02760 ENOG4105C85 amino acid F0335_RS02780 ENOG4107ZQV short-chain dehydrogenase reductase F0335_RS02795 ENOG4108V8F Transcriptional regulator, MarR family F0335_RS02810 ENOG4105C26 Dehydrogenase F0335_RS02845 ENOG4105EFA 4-hydroxyphenylacetate F0335_RS02850 ENOG4107UWN reductase F0335_RS02855 ENOG4107R6D beta-lactam binding protein AmpH F0335_RS02870 ENOG4105ERH Fumarylacetoacetate hydrolase F0335_RS02875 ENOG4105DIA mandelate racemase muconate lactonizing F0335_RS02885 ENOG4105CHR reductase F0335_RS02890 ENOG4105QJH Domain of unknown function (DUF718) F0335_RS02895 ENOG4105EDR glucose galactose transporter F0335_RS02915 ENOG4108IG5 Transcriptional regulator F0335_RS02920 ENOG4105BZU Histidine kinase F0335_RS02925 ENOG4105YBH Protein of unknown function (DUF1435) F0335_RS02950 ENOG4105CPC Aldo Keto reductase F0335_RS02955 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) F0335_RS02960 ENOG4108WPU DNA polymerase III subunit psi F0335_RS02965 ENOG4105KEG ribosomal-protein-alanine acetyltransferase F0335_RS02970 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) F0335_RS02975 ENOG4105K3G Periplasmic Protein F0335_RS02985 ENOG4105VDW Csbd family F0335_RS02990 ENOG4108NRW Phospholipase, patatin family F0335_RS02995 ENOG4105EYA deoxyribonuclease F0335_RS03000 ENOG4105D9N nucleoside F0335_RS03005 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) F0335_RS03015 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) F0335_RS03020 ENOG4105D3A purine nucleoside phosphorylase DeoD-type F0335_RS03025 ENOG4105EUP HipA domain protein F0335_RS03030 ENOG41062Z9 Membrane F0335_RS03035 ENOG4105EAC phosphoserine phosphatase F0335_RS03040 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) F0335_RS03045 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase F0335_RS03055 ENOG4105CIS alcohol dehydrogenase F0335_RS03065 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein F0335_RS03080 ENOG4105C5H ABC transporter F0335_RS03085 ENOG41090EK ompa motb domain protein F0335_RS03090 ENOG4108KHX Diguanylate cyclase F0335_RS03095 ENOG4108WS1 F0335_RS03100 ENOG4107SC1 transglycosylase F0335_RS03105 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) F0335_RS03110 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) F0335_RS03115 ENOG4105CVJ phosphoglycerate mutase F0335_RS03120 ENOG4105UEI Transcriptional Regulator AraC Family F0335_RS03125 ENOG4108RH0 Crea protein F0335_RS03130 ENOG41065U4 response regulator F0335_RS03160 ENOG4105D1Q UPF0246 protein F0335_RS03165 ENOG4105BZG amino acid carrier protein F0335_RS03170 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F0335_RS03175 ENOG4108RIR Molybdenum cofactor biosynthesis protein F0335_RS03180 ENOG4105CSH Transporter F0335_RS03185 ENOG4106HK8 GPR1 FUN34 yaaH family protein F0335_RS03190 ENOG4105CFG Acts as a chaperone (By similarity) F0335_RS03195 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) F0335_RS03200 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) F0335_RS03205 ENOG41063Z6 transcriptional regulator, lysR family F0335_RS03210 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) F0335_RS03215 ENOG410647N response to DNA damage stimulus F0335_RS03220 ENOG4105DTN riboflavin biosynthesis protein ribF F0335_RS03225 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) F0335_RS03230 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) F0335_RS03235 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase F0335_RS03240 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) F0335_RS03245 ENOG4105JQN Transcriptional regulator F0335_RS03265 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) F0335_RS03270 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain F0335_RS03275 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain F0335_RS03295 ENOG4105DWK Membrane F0335_RS03305 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) F0335_RS03315 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) F0335_RS03320 ENOG4105NWN ApaG protein F0335_RS03325 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) F0335_RS03330 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) F0335_RS03340 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) F0335_RS03350 ENOG4105D3G Pseudouridine synthase F0335_RS03355 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) F0335_RS03360 ENOG4105CQ2 DNA polymerase F0335_RS03365 ENOG4108KF1 Membrane F0335_RS03370 ENOG4105M71 acetolactate synthase 1 regulatory subunit F0335_RS03375 ENOG4105C7K acetolactate synthase F0335_RS03390 ENOG4106SMU thiamine transporter membrane protein F0335_RS03395 ENOG4105DP9 ABC transporter F0335_RS03410 ENOG4105S8Q sugar efflux transporter F0335_RS03415 ENOG4107QPK )-transporter F0335_RS03420 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F0335_RS03425 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F0335_RS03430 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) F0335_RS03435 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F0335_RS03445 ENOG41064T2 transcriptional regulator, lysR family F0335_RS03450 ENOG4108IQE Amp-dependent synthetase and ligase F0335_RS03455 ENOG4105C7K acetolactate synthase F0335_RS03460 ENOG4108ZP8 Acetolactate synthase small subunit F0335_RS03465 ENOG4107B7Y DNA-binding transcriptional regulator FruR F0335_RS03470 ENOG4108RNS Exports L-alanine (By similarity) F0335_RS03475 ENOG4108V6E Cell division protein mraZ F0335_RS03480 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) F0335_RS03485 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) F0335_RS03490 ENOG4105CJN penicillin-binding protein F0335_RS03495 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F0335_RS03500 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) F0335_RS03505 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) F0335_RS03515 ENOG4105CNI cell division protein FtsW F0335_RS03520 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) F0335_RS03525 ENOG4105DFU Cell wall formation (By similarity) F0335_RS03535 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) F0335_RS03540 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) F0335_RS03545 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F0335_RS03560 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) F0335_RS03565 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving F0335_RS03570 ENOG4105M6F mutator MutT protein F0335_RS03575 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) F0335_RS03580 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) F0335_RS03585 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) F0335_RS03590 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F0335_RS03595 ENOG4105D7Q type ii secretion system F0335_RS03600 ENOG4107QHF type ii secretion system protein e F0335_RS03605 ENOG4108ZUW Major pilin subunit F0335_RS03610 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase F0335_RS03615 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase F0335_RS03620 ENOG4106A72 regulatory protein AmpE F0335_RS03625 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase F0335_RS03635 ENOG4108YX9 iron--sulfur cluster insertion protein erpA F0335_RS03645 ENOG4105EN6 Membrane F0335_RS03655 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) F0335_RS03660 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein F0335_RS03665 ENOG4105C0H protease F0335_RS03675 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F0335_RS03680 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F0335_RS03685 ENOG4105DXN mazG family F0335_RS03690 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) F0335_RS03715 ENOG4105C85 amino acid F0335_RS03720 ENOG4105C84 Histidine ammonia-lyase F0335_RS03725 ENOG4105CGP Urocanate hydratase F0335_RS03735 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F0335_RS03740 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase F0335_RS03745 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F0335_RS03750 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) F0335_RS03755 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) F0335_RS03760 ENOG4108MXK alkaline phosphatase isozyme conversion F0335_RS03765 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F0335_RS03770 ENOG4105C11 sulfate adenylyltransferase), subunit 2 F0335_RS03775 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) F0335_RS03780 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) F0335_RS03785 ENOG4105N0Z inner membrane protein ygbE F0335_RS03790 ENOG4105CDA abc transporter atp-binding protein F0335_RS03795 ENOG4105E5Q amino acid AbC transporter F0335_RS03800 ENOG4106PMH Extracellular solute-binding protein family 3 F0335_RS03805 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) F0335_RS03810 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) F0335_RS03815 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) F0335_RS03820 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) F0335_RS03830 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) F0335_RS03835 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) F0335_RS03840 ENOG4108K5P (LipO)protein F0335_RS03860 ENOG4105CPC Aldo Keto reductase F0335_RS03865 ENOG4107EXU Short-chain dehydrogenase reductase Sdr F0335_RS03870 ENOG4105EQ2 LysR family Transcriptional regulator F0335_RS03875 ENOG4105VZJ PTS System F0335_RS03880 ENOG4105CK1 PTS System F0335_RS03885 ENOG4105CS2 ec 3.2.1.21 F0335_RS03915 ENOG4105Y3E Modulates RecA activity (By similarity) F0335_RS03920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F0335_RS03945 ENOG4107VXZ Hydrolase F0335_RS03950 ENOG4105W39 Membrane F0335_RS03955 ENOG4105D9M gamma-glutamylcysteine synthetase F0335_RS03965 ENOG4108JU6 CBS domain protein F0335_RS03970 ENOG4106KVJ cytochrome C assembly protein F0335_RS03975 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY F0335_RS03980 ENOG4105K5M 30s ribosomal protein S16 F0335_RS03985 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) F0335_RS03995 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) F0335_RS04000 ENOG4105ZTC transcriptional activator, Ogr delta F0335_RS04020 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F0335_RS04025 ENOG4105EHE chorismate mutase- prephenate dehydrogenase F0335_RS04030 ENOG4105CQC Prephenate dehydratase F0335_RS04035 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA F0335_RS04040 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane F0335_RS04045 ENOG4105C34 Pseudouridine synthase F0335_RS04050 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F0335_RS04055 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F0335_RS04090 ENOG4105CV8 reductase F0335_RS04095 ENOG4105HEI LysR family (Transcriptional regulator F0335_RS04100 ENOG4107NA1 Endonuclease Exonuclease phosphatase F0335_RS04105 ENOG4105E9H Lytic Murein transglycosylase F0335_RS04115 ENOG4105D1A Methyltransferase F0335_RS04120 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F0335_RS04125 ENOG4107RZZ dna polymerase iii epsilon subunit F0335_RS04150 ENOG4105C5R Aminotransferase F0335_RS04165 ENOG4105CHM Aminotransferase F0335_RS04170 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) F0335_RS04175 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) F0335_RS04180 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) F0335_RS04185 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) F0335_RS04190 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) F0335_RS04200 ENOG4107QPN acyl-Coa dehydrogenase F0335_RS04205 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) F0335_RS04210 ENOG4105E7A Glutamine amidotransferase F0335_RS04215 ENOG4105F7V ErfK ybiS ycfS ynhG family protein F0335_RS04220 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) F0335_RS04225 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) F0335_RS04230 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) F0335_RS04235 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) F0335_RS04240 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) F0335_RS04245 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) F0335_RS04250 ENOG4105CJ2 (LipO)protein F0335_RS04275 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F0335_RS04280 ENOG4105CIN aminoacyl-histidine dipeptidase F0335_RS04285 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) F0335_RS04290 ENOG4105V1F Fermentation respiration switch protein F0335_RS04295 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) F0335_RS04315 ENOG4105YB8 TM2 domain containing protein F0335_RS04345 ENOG4105CPW cytochrome b561 F0335_RS04350 ENOG4105DEF Extracellular solute-binding protein, family 5 F0335_RS04355 ENOG4108MEJ flavin reductase domain protein F0335_RS04360 ENOG4105KVH Transcriptional regulator F0335_RS04365 ENOG4108X0B nad(p)h dehydrogenase (quinone) F0335_RS04380 ENOG4108Z33 Thiol disulfide Interchange Protein F0335_RS04385 ENOG4108WFR AraC Family Transcriptional Regulator F0335_RS04390 ENOG4105C26 Dehydrogenase F0335_RS04400 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F0335_RS04415 ENOG4107QS8 (LipO)protein F0335_RS04420 ENOG4107RA9 decarboxylase F0335_RS04430 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) F0335_RS04435 ENOG4105RI1 glycoprotein receptor F0335_RS04450 ENOG4105E98 transcriptional regulator DeoR family F0335_RS04455 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase F0335_RS04460 ENOG4105JQN Transcriptional regulator F0335_RS04465 ENOG4105EUB pirin domain protein F0335_RS04470 ENOG4105CHJ isochorismatase hydrolase F0335_RS04480 ENOG4105KIR Thiol-disulfide oxidoreductase dcc F0335_RS04490 ENOG41068WN F0335_RS04495 ENOG4105G4C Periplasmic ligand-binding sensor protein F0335_RS04505 ENOG4105F2W methyltransferase F0335_RS04510 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F0335_RS04550 ENOG4105XYF acetyltransferase F0335_RS04555 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) F0335_RS04570 ENOG4105SS3 F0335_RS04575 ENOG4108SF5 RNA Polymerase F0335_RS04610 ENOG4105NBK UPF0345 protein F0335_RS04615 ENOG4105DH7 May be involved in recombination (By similarity) F0335_RS04620 ENOG4105DKQ ROK family F0335_RS04640 ENOG4105EYH Exonuclease F0335_RS04645 ENOG4107RH8 nuclease SbcCD subunit D F0335_RS04650 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0335_RS04655 ENOG4105BZU Histidine kinase F0335_RS04660 ENOG4105DJH phosphate F0335_RS04665 ENOG4105CWM branched-chain amino acid transport system II carrier protein F0335_RS04670 ENOG4105C85 amino acid F0335_RS04675 ENOG41084S7 Plasmid maintenance system antidote protein F0335_RS04690 ENOG4105CUY Mechanosensitive ion channel F0335_RS04695 ENOG4107R28 alpha amylase, catalytic region F0335_RS04705 ENOG4105D3R alkyl hydroperoxide reductase F0335_RS04710 ENOG4108ZYK Acyl carrier protein phosphodiesterase F0335_RS04715 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) F0335_RS04720 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) F0335_RS04725 ENOG4105VIE preprotein translocase, subunit YajC F0335_RS04735 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F0335_RS04740 ENOG4108KIC (LipO)protein F0335_RS04745 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) F0335_RS04750 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F0335_RS04755 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) F0335_RS04760 ENOG4107YIM Involved in the transcription termination process (By similarity) F0335_RS04765 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) F0335_RS04770 ENOG4108ZAI phosphatidylglycerophosphatase a F0335_RS04775 ENOG4105CPC Aldo Keto reductase F0335_RS04780 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) F0335_RS04785 ENOG4105CTB Polyprenyl synthetase F0335_RS04790 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) F0335_RS04795 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) F0335_RS04800 ENOG4107S0N DJ-1 family F0335_RS04805 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) F0335_RS04810 ENOG4108VPT UPF0234 protein F0335_RS04815 ENOG4107RDB Major Facilitator F0335_RS04820 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) F0335_RS04825 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) F0335_RS04830 ENOG4105CCU oxidase (Subunit III) F0335_RS04835 ENOG4105BZ9 Cytochrome C oxidase, subunit I F0335_RS04840 ENOG4105E2S oxidase) subunit II F0335_RS04845 ENOG4105EYM Major Facilitator superfamily F0335_RS04850 ENOG4105IEY (LipO)protein F0335_RS04855 ENOG4105M85 Bola protein F0335_RS04860 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation F0335_RS04870 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) F0335_RS04875 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) F0335_RS04885 ENOG4105EIN peptidylprolyl cis-trans isomerase F0335_RS04890 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein F0335_RS04895 ENOG4108TGP Thioesterase superfamily protein F0335_RS04900 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) F0335_RS04905 ENOG4108NFA extracellular solute-binding protein F0335_RS04910 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) F0335_RS04920 ENOG4108XM1 transcriptional regulator AsnC family F0335_RS04925 ENOG4105BZ1 (ABC) transporter F0335_RS04930 ENOG4105BZ1 (ABC) transporter F0335_RS04935 ENOG4108YZA Nitrogen regulatory protein pii F0335_RS04940 ENOG4105BZU Histidine kinase F0335_RS04945 ENOG4105C29 acyl-CoA thioesterase F0335_RS04950 ENOG4108MNP Glycoprotein polysaccharide metabolism F0335_RS04955 ENOG41080UX Methyltransferase F0335_RS04965 ENOG4105KF5 hemolysin expression-modulating protein F0335_RS04970 ENOG4108UKR Biofilm formation regulator YbaJ F0335_RS04980 ENOG4105DIK (ABC) transporter F0335_RS04985 ENOG4105CC5 ABC transporter F0335_RS04990 ENOG4105DSE periplasmic solute binding protein F0335_RS04995 ENOG4105YK5 50S ribosomal protein L36 F0335_RS05000 ENOG4105NRA 50s ribosomal protein l31 type b F0335_RS05005 ENOG4105BZS acriflavin resistance protein F0335_RS05010 ENOG4105C1P efflux transporter, rnd family, mfp subunit F0335_RS05015 ENOG4107XI7 Tetr family transcriptional regulator F0335_RS05020 ENOG41090EX DsrE family F0335_RS05025 ENOG4105EGS Mechanosensitive ion channel F0335_RS05030 ENOG4106428 Protein of unknown function (DUF2496) F0335_RS05040 ENOG4105WD1 Membrane F0335_RS05045 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) F0335_RS05050 ENOG4107QMP dna polymerase iii subunits gamma and tau F0335_RS05055 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) F0335_RS05060 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) F0335_RS05065 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) F0335_RS05070 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) F0335_RS05075 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR F0335_RS05080 ENOG4107QQ0 gntp family F0335_RS05085 ENOG4105BZW Glycerate kinase F0335_RS05090 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) F0335_RS05095 ENOG4107RE1 Inosine-guanosine kinase F0335_RS05100 ENOG4105CKD glutathione-regulated potassium-efflux system protein F0335_RS05105 ENOG4105EU0 Major facilitator Superfamily F0335_RS05110 ENOG4105CGH 5'-nucleotidase F0335_RS05115 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family F0335_RS05120 ENOG4108Z66 YbaK ebsC protein F0335_RS05125 ENOG4105MBR gumn family F0335_RS05130 ENOG4105C59 p-type ATPase F0335_RS05135 ENOG4108Z6Z Transcriptional regulator F0335_RS05140 ENOG4105G5H Membrane F0335_RS05145 ENOG4107QX8 SPFH domain, Band 7 family protein F0335_RS05150 ENOG4107653 Transcriptional regulator F0335_RS05165 ENOG41060W2 glyoxylate carboligase F0335_RS05170 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) F0335_RS05175 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F0335_RS05180 ENOG4105CSP Major Facilitator Superfamily F0335_RS05185 ENOG4105BZW Glycerate kinase F0335_RS05190 ENOG4105S0E allantoin catabolism protein F0335_RS05200 ENOG4105CE7 Amidase, hydantoinase carbamoylase family F0335_RS05205 ENOG4105DG4 malate L-lactate dehydrogenase F0335_RS05210 ENOG4107R1Q Membrane protein FdrA F0335_RS05215 ENOG4107REC cytoplasmic protein F0335_RS05220 ENOG4105G5A Protein of unknown function (DUF2877) F0335_RS05225 ENOG4105C5B carbamate kinase F0335_RS05230 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F0335_RS05235 ENOG4107QR8 Thioredoxin F0335_RS05240 ENOG4105E1F short-chain dehydrogenase reductase F0335_RS05245 ENOG4108UJV acyl-CoA thioesterase i F0335_RS05250 ENOG4108I0Y (ABC) transporter F0335_RS05255 ENOG4105CV6 ABC transporter, permease F0335_RS05260 ENOG4107QNK )-transporter F0335_RS05265 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit F0335_RS05270 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F0335_RS05275 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) F0335_RS05280 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) F0335_RS05285 ENOG4105C8N cysteinyl-tRNA synthetase F0335_RS05290 ENOG4105WQ3 Rna-binding protein F0335_RS05295 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) F0335_RS05325 ENOG4105CPC Aldo Keto reductase F0335_RS05330 ENOG4105EQ2 LysR family Transcriptional regulator F0335_RS05340 ENOG4105BZU Histidine kinase F0335_RS05345 ENOG4105VEQ Cold shock protein F0335_RS05355 ENOG4105CDA abc transporter atp-binding protein F0335_RS05360 ENOG4105DRP amino acid AbC transporter F0335_RS05370 ENOG4105EAB amino acid AbC transporter F0335_RS05390 ENOG4105C2C drug resistance transporter, Bcr CflA F0335_RS05395 ENOG4105YA8 Transcriptional regulator F0335_RS05400 ENOG4107Z6W Protein CrcB homolog F0335_RS05410 ENOG4105BZU Histidine kinase F0335_RS05415 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) F0335_RS05420 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) F0335_RS05425 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) F0335_RS05430 ENOG4108Z43 UPF0250 protein F0335_RS05435 ENOG4105DZ1 carboxypeptidase F0335_RS05440 ENOG4105K6T rare lipoprotein A F0335_RS05445 ENOG4105CNI cell division protein FtsW F0335_RS05450 ENOG4105CJN penicillin-binding protein F0335_RS05455 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) F0335_RS05460 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) F0335_RS05465 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) F0335_RS05470 ENOG4105DJF DNA polymerase III, delta' subunit F0335_RS05475 ENOG4108U2H Rare lipoprotein B F0335_RS05480 ENOG4105C8T Leucyl-tRNA synthetase F0335_RS05485 ENOG4107PAI alpha helical protein F0335_RS05495 ENOG4105DU0 nucleoside hydrolase F0335_RS05500 ENOG4105CDA abc transporter atp-binding protein F0335_RS05505 ENOG4105DRP amino acid AbC transporter F0335_RS05515 ENOG4107RP9 extracellular solute-binding protein, family 3 F0335_RS05520 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) F0335_RS05525 ENOG4108JU5 Magnesium and cobalt efflux protein F0335_RS05530 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) F0335_RS05535 ENOG4105C9A Phoh family F0335_RS05540 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA F0335_RS05545 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) F0335_RS05550 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family F0335_RS05585 ENOG4105CAQ asparagine synthetase F0335_RS05590 ENOG4105E03 chitinase F0335_RS05595 ENOG4105D4U had-superfamily hydrolase, subfamily iia F0335_RS05600 ENOG4105E2R ROK family F0335_RS05605 ENOG4105CE4 GlcNAc 6-P deacetylase F0335_RS05610 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) F0335_RS05615 ENOG4105CI1 PTS System F0335_RS05620 ENOG4105CX6 glutaminyL-tRNA synthetase F0335_RS05625 ENOG4105J5J Outer membrane porin F0335_RS05630 ENOG4105GX6 (LipO)protein F0335_RS05640 ENOG41090R7 Ferric uptake F0335_RS05645 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) F0335_RS05650 ENOG4105NNH LexA regulated protein F0335_RS05655 ENOG4105EV9 Alpha Beta Hydrolase F0335_RS05665 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 F0335_RS05670 ENOG4105NTW Transcriptional regulator F0335_RS05680 ENOG4105EEX Two component transcriptional regulator (Winged helix family F0335_RS05685 ENOG4105C08 Histidine kinase F0335_RS05690 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) F0335_RS05695 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F0335_RS05700 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F0335_RS05710 ENOG4105XIQ Protein of unknown function (DUF2517) F0335_RS05715 ENOG4107SEY Conserved Protein F0335_RS05720 ENOG4105CVP deoxyribo-dipyrimidine photolyase F0335_RS05725 ENOG4107RF4 Phosphodiesterase F0335_RS05730 ENOG4107QNR UPF0135 protein F0335_RS05735 ENOG4105P4J Allophanate hydrolase, subunit 1 F0335_RS05740 ENOG4107R7A Allophanate hydrolase subunit 2 F0335_RS05745 ENOG4105E7W lamb ycsf family protein F0335_RS05765 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) F0335_RS05770 ENOG4105BZN citrate synthase F0335_RS05775 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit F0335_RS05780 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein F0335_RS05785 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) F0335_RS05790 ENOG4105E33 succinate dehydrogenase F0335_RS05795 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 F0335_RS05800 ENOG4105C7S Dehydrogenase F0335_RS05805 ENOG4105CMV Succinyl-CoA synthetase subunit beta F0335_RS05810 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha F0335_RS05820 ENOG4105C4M (Ubiquinol oxidase) subunit I F0335_RS05825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F0335_RS05835 ENOG4105KJB cyd operon protein YbgE F0335_RS05840 ENOG4107YD3 Thioesterase F0335_RS05845 ENOG4105E02 MotA TolQ exbB proton channel F0335_RS05855 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA F0335_RS05860 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) F0335_RS05865 ENOG4105KCK Peptidoglycan-associated lipoprotein F0335_RS05870 ENOG4105UFD tol-pal system protein YbgF F0335_RS05915 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) F0335_RS05920 ENOG4106Z1T Nicotinamide Mononucleotide Transporter F0335_RS05925 ENOG4105PGM cation diffusion facilitator family transporter F0335_RS05930 ENOG4105BZU Histidine kinase F0335_RS05935 ENOG4108WQH regulatoR F0335_RS05940 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F0335_RS05955 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F0335_RS05965 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) F0335_RS05970 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) F0335_RS05975 ENOG4105F0Z galactose-1-phosphate uridylyltransferase F0335_RS05990 ENOG4105DKW ABC transporter F0335_RS05995 ENOG4105F4R Transcriptional regulator mode F0335_RS06000 ENOG4105E0K tonB-dependent siderophore receptor F0335_RS06010 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) F0335_RS06015 ENOG4105EHG Permease protein F0335_RS06020 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) F0335_RS06030 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein F0335_RS06035 ENOG4105E0C molybdate abc transporter F0335_RS06045 ENOG4108K4B hydrolase F0335_RS06050 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) F0335_RS06055 ENOG4108V1U phospholipid-binding protein F0335_RS06095 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) F0335_RS06100 ENOG4105VYA Uncharacterized conserved protein (DUF2132) F0335_RS06105 ENOG4105CHW UPF0052 protein F0335_RS06110 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F0335_RS06115 ENOG4108RIR Molybdenum cofactor biosynthesis protein F0335_RS06120 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F0335_RS06125 ENOG4105M00 molybdopterin converting factor, subunit 1 F0335_RS06130 ENOG4108ZAF Molybdopterin F0335_RS06135 ENOG4105HFZ Membrane F0335_RS06140 ENOG4107QWP ABC-2 type transporter F0335_RS06145 ENOG4107QWP ABC-2 type transporter F0335_RS06150 ENOG4105CJ1 ABC, transporter F0335_RS06155 ENOG4105D0S secretion protein (HlyD F0335_RS06160 ENOG4107MVR Transcriptional regulator F0335_RS06165 ENOG4105C1J atp-dependent rna helicase F0335_RS06170 ENOG4108JQ1 Dehydrogenase F0335_RS06175 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) F0335_RS06185 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0335_RS06190 ENOG4107RCV ABC transporter, permease F0335_RS06195 ENOG4105C4Y ABC transporter F0335_RS06200 ENOG4105CXY transporter F0335_RS06205 ENOG4105BZU Histidine kinase F0335_RS06210 ENOG4108KX4 response regulator F0335_RS06215 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase F0335_RS06220 ENOG4105CHR reductase F0335_RS06225 ENOG4105ETT transcriptional Regulator, LysR family F0335_RS06235 ENOG4105C85 amino acid F0335_RS06245 ENOG4105HEI LysR family (Transcriptional regulator F0335_RS06250 ENOG4105KHU inner membrane protein YohD F0335_RS06260 ENOG4105ECQ AraC Family Transcriptional Regulator F0335_RS06265 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) F0335_RS06300 ENOG4105CKW Inner membrane protein yedI F0335_RS06310 ENOG4105D01 (LipO)protein F0335_RS06320 ENOG4108U7W acetyltransferase F0335_RS06330 ENOG41069YE inner membrane protein yohC F0335_RS06345 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) F0335_RS06355 ENOG4105EHG Permease protein F0335_RS06360 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F0335_RS06365 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor F0335_RS06370 ENOG4105CXG d-lactate dehydrogenase F0335_RS06375 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F0335_RS06385 ENOG4105CPF Cell wall formation (By similarity) F0335_RS06390 ENOG4105E89 ABC transporter F0335_RS06395 ENOG4105CHM Aminotransferase F0335_RS06405 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F0335_RS06425 ENOG4105S10 periplasmic binding protein F0335_RS06430 ENOG4105EHG Permease protein F0335_RS06435 ENOG4108W0P ABC transporter F0335_RS06440 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein F0335_RS06445 ENOG41082A2 Alpha beta hydrolase F0335_RS06450 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) F0335_RS06480 ENOG4107QJE Chromosome Partitioning Protein F0335_RS06485 ENOG4105N1F Hnh endonuclease F0335_RS06490 ENOG4105CC0 LysR family Transcriptional regulator F0335_RS06495 ENOG4107RTG Major Facilitator superfamily F0335_RS06500 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) F0335_RS06505 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound F0335_RS06510 ENOG4108594 Permease of the drug metabolite transporter F0335_RS06535 ENOG4105E5K Alpha-amylase F0335_RS06540 ENOG4108MJ3 acetyltransferase F0335_RS06555 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction F0335_RS06560 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction F0335_RS06565 ENOG4108IND Tetr family transcriptional regulator F0335_RS06570 ENOG4105D01 (LipO)protein F0335_RS06575 ENOG4108UMI ABC transporter, permease F0335_RS06580 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F0335_RS06585 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F0335_RS06605 ENOG4106KE4 Dehydrogenase F0335_RS06620 ENOG4105EHI Phosphonate ABC transporter, periplasmic F0335_RS06635 ENOG4108W15 Protein of unknown function (DUF1456) F0335_RS06655 ENOG4105DRR Transcriptional regulator, GntR family F0335_RS06675 ENOG4105C0Z ABC transporter F0335_RS06680 ENOG4108IV0 ABC, transporter F0335_RS06710 ENOG4107NQ8 LysR family Transcriptional regulator F0335_RS06715 ENOG4105KHC sulfurtransferase F0335_RS06720 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F0335_RS06725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0335_RS06735 ENOG4108TGY Glutathione S-transferase F0335_RS06745 ENOG4105EFZ amidohydrolase F0335_RS06755 ENOG4105CHJ isochorismatase hydrolase F0335_RS06760 ENOG4105EQ1 Transcriptional regulator F0335_RS06775 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system F0335_RS06780 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component F0335_RS06785 ENOG4108IJ8 ABC transporter F0335_RS06790 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component F0335_RS06815 ENOG4105CR8 Transcriptional regulator F0335_RS06825 ENOG4105FDR Membrane F0335_RS06870 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family F0335_RS06875 ENOG4105CD5 CoA-binding domain protein F0335_RS06885 ENOG4108N27 Glutathione S-transferase F0335_RS06890 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase F0335_RS06895 ENOG4105MDS 4-oxalocrotonate tautomerase F0335_RS06900 ENOG4105DVT helicase F0335_RS06915 ENOG4108JU7 Transcriptional regulator F0335_RS06920 ENOG4105CR4 methylisocitrate lyase F0335_RS06925 ENOG4105BZN citrate synthase F0335_RS06930 ENOG4105DXD 2-methylcitrate dehydratase F0335_RS06935 ENOG410829K Lysine exporter protein (Lyse ygga) F0335_RS06955 ENOG4108MTB glycosyl transferase family F0335_RS06965 ENOG4107B2H carbonic anhydrase F0335_RS06970 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction F0335_RS06975 ENOG4105EW6 flavin reductase domain protein, FMN-binding F0335_RS06980 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) F0335_RS06990 ENOG4107SDU Methyl-accepting chemotaxis F0335_RS06995 ENOG4108RZE Tetr family transcriptional regulator F0335_RS07010 ENOG4105D8X mechanosensitive ion channel F0335_RS07015 ENOG4105CDA abc transporter atp-binding protein F0335_RS07020 ENOG4105E5Q amino acid AbC transporter F0335_RS07025 ENOG4107R0W ABC transporter F0335_RS07030 ENOG4105KSC Transcriptional regulator, TraR DksA family F0335_RS07045 ENOG4108R66 Conserved Protein F0335_RS07055 ENOG4108T1M outer membrane protein x F0335_RS07060 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase F0335_RS07075 ENOG4105C6Z Gluconate F0335_RS07080 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) F0335_RS07085 ENOG4105FB2 class II Aldolase F0335_RS07090 ENOG4105G63 Type III effector Hrp-dependent F0335_RS07095 ENOG4105ZXK Dehydrogenase F0335_RS07100 ENOG4105MVE transcriptional regulator F0335_RS07110 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) F0335_RS07115 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) F0335_RS07150 ENOG4108NN8 Fimbrial protein F0335_RS07155 ENOG4108N3D putative enzyme F0335_RS07160 ENOG4106PYX Receptor F0335_RS07170 ENOG4105BZU Histidine kinase F0335_RS07175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0335_RS07180 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) F0335_RS07185 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) F0335_RS07200 ENOG4105C94 Transporter F0335_RS07205 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) F0335_RS07210 ENOG4105C26 Dehydrogenase F0335_RS07215 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) F0335_RS07220 ENOG4105CBC glutamate synthase F0335_RS07230 ENOG4105CMB EAL domain-containing protein F0335_RS07240 ENOG4108VCD Chaperone F0335_RS07245 ENOG4105CW0 outer membrane usher protein F0335_RS07255 ENOG4105UEI Transcriptional Regulator AraC Family F0335_RS07260 ENOG4105DWT malate dehydrogenase (quinone) F0335_RS07270 ENOG4105CYM Glutathione S-transferase F0335_RS07275 ENOG4108ZHR arsR family transcriptional regulator F0335_RS07290 ENOG410642W LysR family Transcriptional regulator F0335_RS07305 ENOG4105YCT UPF0386 protein F0335_RS07310 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) F0335_RS07315 ENOG4107B2H carbonic anhydrase F0335_RS07320 ENOG4105DND Transcriptional regulator F0335_RS07330 ENOG4105C5H ABC transporter F0335_RS07335 ENOG4105D06 uba thif-type nad fad binding protein F0335_RS07340 ENOG4105CVM Molybdenum cofactor synthesis domain protein F0335_RS07350 ENOG4105D44 asparaginase F0335_RS07360 ENOG4105DEF Extracellular solute-binding protein, family 5 F0335_RS07365 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F0335_RS07370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F0335_RS07395 ENOG4105EGI Transcriptional regulator F0335_RS07400 ENOG4105CBP Major Facilitator F0335_RS07405 ENOG4105EUJ GTP cyclohydrolase i F0335_RS07410 ENOG4105DHF Membrane F0335_RS07415 ENOG41060NJ transcriptional regulator F0335_RS07430 ENOG4107SDZ Galactoside transport system permease protein mglC F0335_RS07440 ENOG4107GZ4 SanA protein F0335_RS07445 ENOG4107R1I NAD-dependent malic enzyme F0335_RS07450 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) F0335_RS07455 ENOG41067MG lrgb family F0335_RS07460 ENOG4105VAW lrga family F0335_RS07475 ENOG4105D75 Capsular exopolysaccharide family F0335_RS07480 ENOG4107ZF2 Phosphatase F0335_RS07485 ENOG4105DAY polysaccharide export protein F0335_RS07490 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F0335_RS07495 ENOG4105E5W Transporter F0335_RS07505 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F0335_RS07510 ENOG4105D1F ATP-binding protein F0335_RS07515 ENOG4105MH5 phosphoesterase PA-phosphatase related protein F0335_RS07520 ENOG4105DBI uridine monophosphokinase F0335_RS07525 ENOG4105DHP deoxycytidine triphosphate deaminase F0335_RS07530 ENOG4108GAE asmA family F0335_RS07535 ENOG4105CEE C4-dicarboxylate transporter F0335_RS07540 ENOG4105EE5 Membrane protein terC F0335_RS07545 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F0335_RS07550 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) F0335_RS07560 ENOG4105CG5 Glycosyl transferase (Group 1 F0335_RS07580 ENOG4105D3Q Sugar transferase F0335_RS07595 ENOG4108JJ6 Type I secretion system ATPase F0335_RS07600 ENOG4107QZV Type I secretion membrane fusion protein F0335_RS07605 ENOG4105DFG type I secretion outer membrane protein F0335_RS07610 ENOG4105CJT Mannose-1-phosphate guanylyltransferase F0335_RS07615 ENOG4107QKV phosphomannomutase F0335_RS07620 ENOG4105CMR udp-glucose 4-epimerase F0335_RS07625 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase F0335_RS07645 ENOG4105EY8 ABC transporter F0335_RS07660 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) F0335_RS07665 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase F0335_RS07670 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) F0335_RS07675 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase F0335_RS07690 ENOG4105CIH Imidazole acetol-phosphate transaminase F0335_RS07695 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) F0335_RS07700 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) F0335_RS07710 ENOG4107SRH Nad-dependent epimerase dehydratase F0335_RS07715 ENOG4105CC0 LysR family Transcriptional regulator F0335_RS07725 ENOG4105EVZ LysR family transcriptional regulator F0335_RS07730 ENOG4105CYW agmatinase F0335_RS07735 ENOG4107QN1 sodium solute F0335_RS07740 ENOG4105ETS cytosine purines uracil thiamine allantoin F0335_RS07745 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase F0335_RS07780 ENOG4105D7N magnesium and cobalt transport protein CorA F0335_RS07790 ENOG4105D8V Glucose sorbosone dehydrogenase F0335_RS07795 ENOG4108TGY Glutathione S-transferase F0335_RS07815 ENOG4105C28 cystathionine F0335_RS07825 ENOG4105DZ1 carboxypeptidase F0335_RS07850 ENOG4108RQP Major type 1 subunit fimbrin F0335_RS07855 ENOG4106PG1 outer membrane usher protein F0335_RS07860 ENOG4108FZ9 Chaperone F0335_RS07880 ENOG4108V1T peptidylprolyl cis-trans isomerase F0335_RS07885 ENOG41068CG regulatoR F0335_RS07890 ENOG4105EJQ L-serine dehydratase F0335_RS07895 ENOG4105C44 Serine transporter F0335_RS07900 ENOG4107FB0 transcriptional regulator DeoR family F0335_RS07905 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) F0335_RS07915 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F0335_RS07930 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) F0335_RS07935 ENOG4105ETT transcriptional Regulator, LysR family F0335_RS07940 ENOG4107S2N Type III effector Hrp-dependent F0335_RS07945 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) F0335_RS07970 ENOG4108KPJ rna polymerase sigma factor F0335_RS07975 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F0335_RS07980 ENOG4105D0C transport protein F0335_RS07985 ENOG4105GWF inner membrane protein YbjM F0335_RS07990 ENOG41090BQ Glutaredoxin F0335_RS07995 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress F0335_RS08000 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) F0335_RS08005 ENOG4108RMJ sensory transduction regulator F0335_RS08010 ENOG4107RUE extracellular solute-binding protein family 1 F0335_RS08015 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0335_RS08020 ENOG4105F38 ABC transporter, permease F0335_RS08025 ENOG4105D38 putrescine abc transporter F0335_RS08030 ENOG4105RBQ inner membrane protein ybjO F0335_RS08035 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) F0335_RS08040 ENOG4106TNF Periplasmic binding protein F0335_RS08045 ENOG4105DMR ABC, transporter F0335_RS08050 ENOG4105GBT ABC transporter F0335_RS08055 ENOG4106PMH Extracellular solute-binding protein family 3 F0335_RS08060 ENOG4105E5Z arginine transporter ATP-binding subunit F0335_RS08065 ENOG41064MM (LipO)protein F0335_RS08070 ENOG4105K8R UPF0145 protein F0335_RS08080 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase F0335_RS08085 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase F0335_RS08090 ENOG4105CGD Nad-dependent epimerase dehydratase F0335_RS08105 ENOG4105CI1 PTS System F0335_RS08110 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) F0335_RS08115 ENOG4105C5W Aldolase F0335_RS08120 ENOG4105C7K acetolactate synthase F0335_RS08125 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F0335_RS08130 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) F0335_RS08135 ENOG4105DWU Membrane F0335_RS08140 ENOG4105CPB ATP-dependent endonuclease of the OLD family F0335_RS08145 ENOG4108MJ5 VirK protein F0335_RS08150 ENOG4105DJY efflux transporter, rnd family, mfp subunit F0335_RS08160 ENOG4105VEQ Cold shock protein F0335_RS08165 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) F0335_RS08170 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F0335_RS08180 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) F0335_RS08185 ENOG4108JJ8 (ABC) transporter F0335_RS08190 ENOG4108JJ9 ABC, transporter F0335_RS08195 ENOG4108K3A Glutathione S-transferase F0335_RS08200 ENOG4108M0I Transcriptional regulator F0335_RS08205 ENOG4105C3M thioredoxin reductase F0335_RS08210 ENOG4105EW9 transcriptional regulator AsnC family F0335_RS08215 ENOG4105CNU cell division protein FtsK F0335_RS08220 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) F0335_RS08225 ENOG4105D1H recombination factor protein RarA F0335_RS08230 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) F0335_RS08240 ENOG4108ISG Major Facilitator F0335_RS08245 ENOG4105F1A Pyruvate formate-lyase F0335_RS08250 ENOG4105C6N Formate acetyltransferase F0335_RS08255 ENOG4105TMB Formate nitrite transporter F0335_RS08260 ENOG4105DDY UPF0142 protein ycaO F0335_RS08265 ENOG4105HDK L-asparaginase F0335_RS08270 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) F0335_RS08275 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase F0335_RS08280 ENOG4105CAT Cytidine monophosphate kinase F0335_RS08285 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) F0335_RS08295 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 F0335_RS08300 ENOG4105BZ1 (ABC) transporter F0335_RS08305 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) F0335_RS08310 ENOG4105E32 cytoplasmic protein F0335_RS08320 ENOG4105VEQ Cold shock protein F0335_RS08325 ENOG4105T0Z Conserved Protein F0335_RS08330 ENOG4105W49 UPF0434 protein F0335_RS08335 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) F0335_RS08340 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups F0335_RS08345 ENOG4107S90 membrAne F0335_RS08350 ENOG4106371 Methyltransferase F0335_RS08355 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) F0335_RS08365 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) F0335_RS08370 ENOG4105DIT ErfK YbiS YcfS YnhG family protein F0335_RS08375 ENOG4105EAQ (twin-arginine translocation) pathway signal F0335_RS08380 ENOG4105C5X domain protein F0335_RS08385 ENOG4105CGF Aromatic amino acid aminotransferase F0335_RS08395 ENOG4105C5S asparaginyl-tRNA synthetase F0335_RS08400 ENOG4107RH7 Nicotinate phosphoribosyltransferase F0335_RS08405 ENOG4105BZU Histidine kinase F0335_RS08415 ENOG4105CD8 aminopeptidase N F0335_RS08425 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F0335_RS08430 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) F0335_RS08435 ENOG4105GVF (ABC) transporter F0335_RS08445 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) F0335_RS08450 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) F0335_RS08455 ENOG4105QVC MOSC domain-containing protein F0335_RS08460 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) F0335_RS08465 ENOG4105C5H ABC transporter F0335_RS08470 ENOG4105F1S paraquat-inducible protein a F0335_RS08475 ENOG4105DY2 Paraquat-inducible protein b F0335_RS08480 ENOG4108Q2G (LipO)protein F0335_RS08485 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) F0335_RS08490 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F0335_RS08500 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) F0335_RS08505 ENOG4105DAN ATP-dependent protease F0335_RS08525 ENOG4108RZ1 DNA transformation protein F0335_RS08530 ENOG4105EM2 membrane F0335_RS08535 ENOG410901E Membrane F0335_RS08540 ENOG41088T4 Helicase IV F0335_RS08545 ENOG4108Z5K methylglyoxal synthase F0335_RS08555 ENOG4105K4P CoA-binding domain protein F0335_RS08560 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) F0335_RS08565 ENOG4105DR4 Methyltransferase F0335_RS08570 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 F0335_RS08575 ENOG4108Z0T Part of a sulfur-relay system (By similarity) F0335_RS08580 ENOG4108MN8 Membrane F0335_RS08600 ENOG4108Z4X TRANSCRIPTIONal F0335_RS08605 ENOG4105ENT Efflux transporter rnd family, mfp subunit F0335_RS08610 ENOG4105BZS acriflavin resistance protein F0335_RS08625 ENOG4105CS1 NAD(P)H quinone oxidoreductase F0335_RS08660 ENOG4105CSP Major Facilitator Superfamily F0335_RS08680 ENOG4105F27 Major Facilitator F0335_RS08690 ENOG4108U51 Universal stress protein F0335_RS08700 ENOG4105DG4 malate L-lactate dehydrogenase F0335_RS08705 ENOG4107QTZ amino acid F0335_RS08710 ENOG4105CZJ Aldehyde dehydrogenase F0335_RS08715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F0335_RS08725 ENOG4105CTU Proline racemase F0335_RS08760 ENOG4105RA2 Membrane F0335_RS08765 ENOG4105XVG cytoplasmic protein F0335_RS08770 ENOG4105WH1 Two component transcriptional regulator luxr family F0335_RS08775 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) F0335_RS08800 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter F0335_RS08830 ENOG4105CSH Transporter F0335_RS08845 ENOG4105DJY efflux transporter, rnd family, mfp subunit F0335_RS08850 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) F0335_RS08865 ENOG4105GSJ Inner membrane protein ylaC F0335_RS08880 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) F0335_RS08885 ENOG4105DJ9 glucan biosynthesis protein F0335_RS08890 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) F0335_RS08895 ENOG4105NAC (LipO)protein F0335_RS08905 ENOG4108W47 Acidic protein msyB F0335_RS08915 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F0335_RS08925 ENOG41080HT Transcriptional regulator, arsr family F0335_RS08940 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase F0335_RS08945 ENOG4105DUX Transporter F0335_RS08950 ENOG4105C6X Major Facilitator F0335_RS08960 ENOG4105D1S lipid A biosynthesis F0335_RS08970 ENOG4105C72 UPF0176 protein F0335_RS08975 ENOG4108YYC ycei family F0335_RS08980 ENOG4105DS1 cytochrome b561 F0335_RS08985 ENOG4105DSF transport protein F0335_RS09015 ENOG4105PVA Biofilm formation regulatory protein BssS F0335_RS09030 ENOG4105EKE dihydroorotase F0335_RS09035 ENOG41067V3 Antibiotic biosynthesis monooxygenase F0335_RS09040 ENOG4107QQB Ribonuclease E F0335_RS09045 ENOG4105EI2 Pseudouridine synthase F0335_RS09055 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein F0335_RS09060 ENOG4105VGS 50s ribosomal protein l32 F0335_RS09065 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) F0335_RS09070 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F0335_RS09075 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F0335_RS09080 ENOG4105CHR reductase F0335_RS09085 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F0335_RS09090 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F0335_RS09095 ENOG4105YAZ 4-amino-4-deoxychorismate lyase F0335_RS09100 ENOG4105HHA aminodeoxychorismate lyase F0335_RS09105 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) F0335_RS09110 ENOG4107QRG dna polymerase iii F0335_RS09115 ENOG4105F8V Hydrolase, tatD family F0335_RS09120 ENOG4105CI1 PTS System F0335_RS09140 ENOG4105KST dependent repressor F0335_RS09145 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) F0335_RS09150 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr F0335_RS09155 ENOG4105KVH Transcriptional regulator F0335_RS09165 ENOG4105K59 histidine triad (HIT) protein F0335_RS09170 ENOG41090DQ Lipoprotein F0335_RS09175 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) F0335_RS09180 ENOG4108RUM thiamine kinase F0335_RS09190 ENOG4105D0Y UPF0227 protein F0335_RS09195 ENOG4105CEP NADH dehydrogenase F0335_RS09200 ENOG4107MBR 17 kDa surface antigen F0335_RS09220 ENOG4105UEI Transcriptional Regulator AraC Family F0335_RS09245 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase F0335_RS09250 ENOG4107SSZ Phosphatase F0335_RS09255 ENOG4107XHZ cytoplasmic chaperone TorD family protein F0335_RS09260 ENOG4108Q2J Inner membrane protein YebE F0335_RS09265 ENOG4105CUG Oligopeptidase b F0335_RS09270 ENOG4105UMD exodeoxyribonuclease X F0335_RS09285 ENOG4105MPK DNA polymerase III subunit theta F0335_RS09290 ENOG41090A1 ferritin F0335_RS09295 ENOG4105FXM Copper resistance protein F0335_RS09300 ENOG4108PNC copper resistance F0335_RS09375 ENOG4105RKW reductase (By F0335_RS09390 ENOG4108MRH transcriptional regulatory protein F0335_RS09395 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F0335_RS09410 ENOG4105C2J ABC transporter F0335_RS09415 ENOG4105CNN ABC, transporter F0335_RS09430 ENOG4105D01 (LipO)protein F0335_RS09445 ENOG4107WCA isomerase F0335_RS09450 ENOG4107W6W Conserved Protein F0335_RS09455 ENOG4105CQ4 Transcriptional regulator F0335_RS09460 ENOG4105CNT hydrolase family 2 F0335_RS09465 ENOG4105FK9 beta-D-galactosidase beta subunit F0335_RS09470 ENOG4105E5D amino acid F0335_RS09475 ENOG41082SX arsR family transcriptional regulator F0335_RS09485 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F0335_RS09495 ENOG4105GQR Chaperone F0335_RS09505 ENOG4105CW0 outer membrane usher protein F0335_RS09510 ENOG4108MQF Chaperone F0335_RS09535 ENOG4107RSM transcriptional regulator F0335_RS09545 ENOG4105C3G gtp-binding protein F0335_RS09550 ENOG4105CHH sulfate transporter F0335_RS09555 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) F0335_RS09560 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria F0335_RS09565 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F0335_RS09570 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) F0335_RS09575 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) F0335_RS09585 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) F0335_RS09590 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) F0335_RS09595 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F0335_RS09600 ENOG4108YY7 Invasion gene expression up-regulator SirB F0335_RS09605 ENOG41063JG Transcriptional regulator F0335_RS09610 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase F0335_RS09615 ENOG4105CHH sulfate transporter F0335_RS09620 ENOG41090KN UPF0303 protein F0335_RS09625 ENOG4105BZU Histidine kinase F0335_RS09630 ENOG4108JA2 transcriptioN-repair coupling factor F0335_RS09635 ENOG4105D60 lipoprotein releasing system transmembrane protein F0335_RS09645 ENOG4105D60 lipoprotein releasing system transmembrane protein F0335_RS09660 ENOG4108HM4 ABC transporter F0335_RS09670 ENOG4105F8D glycoside hydrolase family 4 F0335_RS09675 ENOG4105CI1 PTS System F0335_RS09680 ENOG4105D38 putrescine abc transporter F0335_RS09700 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) F0335_RS09705 ENOG4105DG4 malate L-lactate dehydrogenase F0335_RS09720 ENOG4105EZE Cupin 4 family protein F0335_RS09730 ENOG4105XJC Two component transcriptional regulator (Winged helix family F0335_RS09735 ENOG4108KD5 ADP-ribosylation crystallin J1 F0335_RS09740 ENOG4105FDP GntR family transcriptional regulator F0335_RS09755 ENOG4105D9U N-acetyltransferase F0335_RS09760 ENOG4107QTF adenylosuccinate lyase F0335_RS09765 ENOG41075W9 High frequency lysogenization protein HflD homolog F0335_RS09775 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) F0335_RS09790 ENOG4108R99 pseudouridine synthase F0335_RS09795 ENOG4108HMX isocitrate dehydrogenase (NADP) F0335_RS09815 ENOG4108I1J Integrase F0335_RS09820 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 F0335_RS09830 ENOG4108MXB Protein of unknown function (DUF968) F0335_RS09835 ENOG4105HRS Antitermination protein F0335_RS09865 ENOG4105FKG DNA packaging protein F0335_RS09870 ENOG4105UZW Tail fiber assembly protein F0335_RS09875 ENOG4107DE1 head-to-tail joining protein F0335_RS09900 ENOG4108RW8 Universal stress protein F F0335_RS09905 ENOG4105M5B (LipO)protein F0335_RS09910 ENOG4105M5B (LipO)protein F0335_RS09915 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA F0335_RS09985 ENOG4105VEQ Cold shock protein F0335_RS09995 ENOG4105CHJ isochorismatase hydrolase F0335_RS10000 ENOG4108M6U Universal stress protein A F0335_RS10005 ENOG41061TZ Short-chain dehydrogenase reductase Sdr F0335_RS10010 ENOG4105CJP fad dependent oxidoreductase F0335_RS10015 ENOG4105C26 Dehydrogenase F0335_RS10020 ENOG4107VRI Transcriptional regulator F0335_RS10025 ENOG4108Z86 Glutamine amidotransferase F0335_RS10030 ENOG4105CFQ glutamine synthetase F0335_RS10050 ENOG4105DRB nucleoside-specific channel-forming protein F0335_RS10065 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) F0335_RS10080 ENOG4105CI2 imidazolone-5-propionate hydrolase F0335_RS10085 ENOG4105CZE histidine utilization repressor F0335_RS10090 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) F0335_RS10095 ENOG41090B9 response to stress F0335_RS10100 ENOG4106NDP Transcriptional regulator F0335_RS10105 ENOG4108HKT sucrose-6-phosphate hydrolase F0335_RS10110 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) F0335_RS10115 ENOG4105CSH Transporter F0335_RS10135 ENOG410642W LysR family Transcriptional regulator F0335_RS10145 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase F0335_RS10155 ENOG4105QNJ serralysin (EC 3.4.24.40) F0335_RS10180 ENOG4105WT8 Protein of unknown function (DUF1480) F0335_RS10215 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B F0335_RS10220 ENOG4105DY2 Paraquat-inducible protein b F0335_RS10225 ENOG4105H2K paraquat-inducible protein a F0335_RS10230 ENOG4108ZGC gaf domain protein F0335_RS10235 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) F0335_RS10240 ENOG4105CN1 protease F0335_RS10245 ENOG4105D0M Protease HtpX homolog F0335_RS10255 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0335_RS10260 ENOG4105J4Q Transcriptional regulator F0335_RS10265 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component F0335_RS10270 ENOG4108MP3 ABC transporter, permease F0335_RS10280 ENOG4105CY5 solute-binding protein F0335_RS10285 ENOG4106S9K Transcriptional regulator F0335_RS10305 ENOG4107K5X Membrane-bound metal-dependent hydrolase F0335_RS10310 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 F0335_RS10320 ENOG4107PN8 YfeABCD locus regulator F0335_RS10330 ENOG4105CC5 ABC transporter F0335_RS10335 ENOG4105CC5 ABC transporter F0335_RS10340 ENOG4105DIK (ABC) transporter F0335_RS10345 ENOG4105DSE periplasmic solute binding protein F0335_RS10350 ENOG4105P10 Uncharacterized protein ydiZ F0335_RS10355 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division F0335_RS10375 ENOG4105C44 Serine transporter F0335_RS10385 ENOG41082NP Multiple antibiotic resistance F0335_RS10405 ENOG4105C22 threonyL-tRNA synthetase F0335_RS10415 ENOG41082NX 50s ribosomal protein l35 F0335_RS10420 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) F0335_RS10430 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) F0335_RS10450 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) F0335_RS10455 ENOG4108V06 Glutathione peroxidase F0335_RS10465 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase F0335_RS10470 ENOG4105CKK Glycosyl transferase, family 2 F0335_RS10475 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) F0335_RS10480 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) F0335_RS10485 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) F0335_RS10490 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) F0335_RS10495 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) F0335_RS10500 ENOG4108QBX (LipO)protein F0335_RS10505 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) F0335_RS10525 ENOG4105EHG Permease protein F0335_RS10530 ENOG4107R4I Periplasmic binding protein F0335_RS10535 ENOG4106QJH hemin transport protein F0335_RS10540 ENOG4107ENK receptor F0335_RS10545 ENOG4107F3C Hemin uptake protein F0335_RS10550 ENOG4108V06 Glutathione peroxidase F0335_RS10555 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F0335_RS10560 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) F0335_RS10565 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) F0335_RS10575 ENOG4105IPI Membrane F0335_RS10580 ENOG4105CQB FAD linked oxidase domain protein F0335_RS10585 ENOG4105KA0 thioesterase Superfamily protein F0335_RS10595 ENOG4108Z4V iron-sulfur cluster assembly F0335_RS10600 ENOG4105DIW FeS assembly protein SUFB F0335_RS10605 ENOG4105C3K feS assembly ATPase SufC F0335_RS10610 ENOG4105JRK feS assembly protein SufD F0335_RS10615 ENOG4105C9B Cysteine desulfurase F0335_RS10620 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) F0335_RS10625 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F0335_RS10635 ENOG4105CA9 Pyruvate kinase F0335_RS10660 ENOG4107QI1 Mate efflux family protein F0335_RS10665 ENOG4108R6K riboflavin synthase, subunit alpha F0335_RS10675 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F0335_RS10680 ENOG4105CZQ inner membrane transport protein YdhC F0335_RS10685 ENOG4105F52 Transcriptional regulator F0335_RS10690 ENOG4105ETE Transcriptional regulator (LacI family F0335_RS10700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0335_RS10705 ENOG4105K4H Nlp p60 protein F0335_RS10710 ENOG4105M2J Glutaredoxin F0335_RS10720 ENOG4108UYE Lactoylglutathione lyase F0335_RS10725 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F0335_RS10730 ENOG4108WUH Transcriptional regulator, TetR family F0335_RS10735 ENOG4105DIJ Phosphoethanolamine transferase F0335_RS10745 ENOG4105HEI LysR family (Transcriptional regulator F0335_RS10750 ENOG4105XZD Fe-S protein F0335_RS10755 ENOG4107RGM aldo keto reductase F0335_RS10765 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0335_RS10770 ENOG4105DSW Fusaric acid resistance protein F0335_RS10775 ENOG4105Y49 secretion protein, HlyD family F0335_RS10785 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) F0335_RS10790 ENOG4108XTF Outer Membrane Lipoprotein F0335_RS10795 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) F0335_RS10805 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) F0335_RS10810 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F0335_RS10825 ENOG4108K3A Glutathione S-transferase F0335_RS10835 ENOG4108ZR5 Conserved Protein F0335_RS10860 ENOG4105KME endoribonuclease L-psp F0335_RS10875 ENOG4105DKK Benzoate F0335_RS10880 ENOG4108JCI Transcriptional regulator F0335_RS10890 ENOG4105DUX Transporter F0335_RS10895 ENOG4105CSM endonuclease III F0335_RS10905 ENOG4108UQQ Electron transport complex F0335_RS10915 ENOG4105UEI Transcriptional Regulator AraC Family F0335_RS10920 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) F0335_RS10925 ENOG4108R3D Electron transport complex F0335_RS10930 ENOG4105DGN Electron transport complex F0335_RS10935 ENOG4105M9B inner membrane protein ydgK F0335_RS10940 ENOG4105D9R oxidoreductase F0335_RS10945 ENOG4105DHU Bile acid F0335_RS10955 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) F0335_RS10965 ENOG4107VIJ nudix hydrolase F0335_RS10975 ENOG4105C87 Aminotransferase class I and II F0335_RS10980 ENOG4105CI1 PTS System F0335_RS10985 ENOG4107P2S Transcriptional regulator F0335_RS10990 ENOG4105ETT transcriptional Regulator, LysR family F0335_RS11005 ENOG410642W LysR family Transcriptional regulator F0335_RS11010 ENOG4107S1E Beta-lactamase F0335_RS11015 ENOG4106J39 exported protein F0335_RS11020 ENOG4105EIP mannose-6-phosphate isomerase F0335_RS11035 ENOG4105C9Q fumarate hydratase class II F0335_RS11040 ENOG4105D29 Helix-turn-helix type 11 domain protein F0335_RS11050 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) F0335_RS11060 ENOG4105F32 YngK protein F0335_RS11065 ENOG4105D94 Major Facilitator Superfamily F0335_RS11075 ENOG4105DAG ROK family F0335_RS11080 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) F0335_RS11090 ENOG4108Z4X TRANSCRIPTIONal F0335_RS11100 ENOG4108IJ8 ABC transporter F0335_RS11105 ENOG4105E90 ABC transporter F0335_RS11110 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system F0335_RS11115 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component F0335_RS11125 ENOG4105KBG Protein of unknown function (DUF1161) F0335_RS11130 ENOG4105M5Q UPF0482 protein F0335_RS11135 ENOG4105KK4 UPF0060 membrane protein F0335_RS11140 ENOG4105EMU Dehydrogenase F0335_RS11150 ENOG4105GAV receptor F0335_RS11160 ENOG4108SF5 RNA Polymerase F0335_RS11165 ENOG4107QUY Guanine deaminase F0335_RS11170 ENOG4108MBX Secretion Protein F0335_RS11175 ENOG4108JJA ABC, transporter F0335_RS11225 ENOG4105DGW oligopeptidase A F0335_RS11230 ENOG4105CSP Major Facilitator Superfamily F0335_RS11235 ENOG4108UAU isochorismatase F0335_RS11240 ENOG4105RE0 Asp Glu hydantoin racemase F0335_RS11250 ENOG4105MSY salicylate hydroxylase F0335_RS11260 ENOG4108VHT MarR family transcriptional regulator F0335_RS11265 ENOG4108XHQ (2Fe-2S)-binding domain protein F0335_RS11270 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding F0335_RS11275 ENOG4107U2T alpha beta F0335_RS11280 ENOG4105C5Q Transcriptional regulator F0335_RS11300 ENOG4108MBX Secretion Protein F0335_RS11315 ENOG4105EXC Acyl-transferase F0335_RS11340 ENOG4105JQN Transcriptional regulator F0335_RS11345 ENOG4105EMU Dehydrogenase F0335_RS11350 ENOG4105Q2H domain protein F0335_RS11360 ENOG4105CCF Lysine exporter protein (Lyse ygga) F0335_RS11365 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F0335_RS11385 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) F0335_RS11400 ENOG4105EQ2 LysR family Transcriptional regulator F0335_RS11405 ENOG4105ENX hydrolase F0335_RS11410 ENOG4105F0F Oxalate decarboxylase F0335_RS11415 ENOG4105C5Y PTS System F0335_RS11420 ENOG4105CS2 ec 3.2.1.21 F0335_RS11425 ENOG4105CID antiterminator F0335_RS11460 ENOG4105CPT Alpha beta hydrolase F0335_RS11470 ENOG4107TV1 YD repeat protein F0335_RS11505 ENOG4105JAB phenazine biosynthesis protein, phzf family F0335_RS11535 ENOG4105C6X Major Facilitator F0335_RS11545 ENOG4105PMV Membrane F0335_RS11555 ENOG4105CJN penicillin-binding protein F0335_RS11575 ENOG4105C8Q Methyl-accepting chemotaxis F0335_RS11580 ENOG41061RM osmotically inducible lipoprotein F0335_RS11600 ENOG410642W LysR family Transcriptional regulator F0335_RS11605 ENOG4107S1E Beta-lactamase F0335_RS11610 ENOG4105F27 Major Facilitator F0335_RS11620 ENOG4105E98 transcriptional regulator DeoR family F0335_RS11625 ENOG4105D9R oxidoreductase F0335_RS11655 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) F0335_RS11660 ENOG4108TEB UPF0114 protein F0335_RS11665 ENOG4105EQ0 Major Facilitator superfamily F0335_RS11670 ENOG4105HEI LysR family (Transcriptional regulator F0335_RS11680 ENOG4107S7U Sulfide dehydrogenase F0335_RS11690 ENOG4107QPB Beta-lactamase domain protein F0335_RS11695 ENOG4105DQ4 alcohol dehydrogenase F0335_RS11700 ENOG4105C26 Dehydrogenase F0335_RS11705 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family F0335_RS11715 ENOG4105F87 Dehydratase F0335_RS11720 ENOG4105C2C drug resistance transporter, Bcr CflA F0335_RS11725 ENOG4105BZU Histidine kinase F0335_RS11745 ENOG4105DRR Transcriptional regulator, GntR family F0335_RS11755 ENOG4108MXF Alpha Beta Hydrolase F0335_RS11760 ENOG4105MXW flavin reductase domain protein, FMN-binding F0335_RS11765 ENOG4108M8W Monooxygenase F0335_RS11770 ENOG4105C26 Dehydrogenase F0335_RS11775 ENOG4105ETS cytosine purines uracil thiamine allantoin F0335_RS11780 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF F0335_RS11795 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) F0335_RS11800 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) F0335_RS11810 ENOG4108IGT Dipeptidase F0335_RS11815 ENOG41090VV Protein of unknown function (DUF2846) F0335_RS11825 ENOG4105DY8 decarboxylase F0335_RS11830 ENOG4108JPW Aminotransferase F0335_RS11835 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F0335_RS11845 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) F0335_RS11855 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase F0335_RS11900 ENOG4107RZC phospholipase d F0335_RS11910 ENOG4105C57 major facilitator superfamily F0335_RS11925 ENOG4105E0K tonB-dependent siderophore receptor F0335_RS11945 ENOG4105C6T cysteine synthase F0335_RS11975 ENOG4107QP6 Xylose isomerase domain protein TIM barrel F0335_RS11980 ENOG4105CIB oxidoreductase Domain protein F0335_RS12010 ENOG4105RHY Pfam:UPF0157 F0335_RS12020 ENOG4108UIN ybak prolyl-trna synthetase associated region F0335_RS12065 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF F0335_RS12070 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein F0335_RS12075 ENOG4105KVH Transcriptional regulator F0335_RS12080 ENOG4105E8G Major facilitator Superfamily F0335_RS12095 ENOG4105E93 esterase F0335_RS12100 ENOG4105E0K tonB-dependent siderophore receptor F0335_RS12105 ENOG4108SGR YheO domain-containing protein F0335_RS12115 ENOG4105D82 Glutamate dehydrogenase F0335_RS12120 ENOG4105CEY Amp-dependent synthetase and ligase F0335_RS12125 ENOG4108Z0Z intracellular protease Pfpi family F0335_RS12135 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F0335_RS12140 ENOG4105BZS acriflavin resistance protein F0335_RS12145 ENOG4105C1P efflux transporter, rnd family, mfp subunit F0335_RS12160 ENOG4105DWY Agmatine deiminase F0335_RS12165 ENOG4105ETT transcriptional Regulator, LysR family F0335_RS12170 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) F0335_RS12175 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit F0335_RS12200 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding F0335_RS12205 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding F0335_RS12210 ENOG4108XHQ (2Fe-2S)-binding domain protein F0335_RS12225 ENOG4108Q3X Transcriptional regulator F0335_RS12230 ENOG4105CS2 ec 3.2.1.21 F0335_RS12235 ENOG4105BZC d-serine deaminase F0335_RS12250 ENOG4105KCV RNA signal recognition particle 4.5S RNA F0335_RS12255 ENOG4105BZU Histidine kinase F0335_RS12275 ENOG4105EGS Mechanosensitive ion channel F0335_RS12280 ENOG4105C5H ABC transporter F0335_RS12290 ENOG4105ECY inositol monophosphatase F0335_RS12295 ENOG41076HS cation diffusion facilitator family transporter F0335_RS12310 ENOG4105CJW magnesium transporter F0335_RS12315 ENOG4107QSI ABC, transporter F0335_RS12360 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) F0335_RS12365 ENOG4105DXC membrane F0335_RS12410 ENOG4105C32 Amino acid ABC transporter (Permease) F0335_RS12415 ENOG4105CF8 branched-chain amino acid ABC transporter, permease F0335_RS12420 ENOG4105C0Z ABC transporter F0335_RS12425 ENOG4108IV0 ABC, transporter F0335_RS12440 ENOG4105CE7 Amidase, hydantoinase carbamoylase family F0335_RS12460 ENOG4105CJ3 phosphate transporter F0335_RS12465 ENOG4105CSR polyphosphate kinase 2 F0335_RS12475 ENOG41061WM D-Alanyl-D-Alanine F0335_RS12480 ENOG4107QPD alcohol dehydrogenase F0335_RS12485 ENOG4105DEN Luciferase family F0335_RS12490 ENOG4105CSW GntR family transcriptional regulator F0335_RS12500 ENOG41089BK Glutamine amido-transferase F0335_RS12510 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) F0335_RS12540 ENOG4105DRS transport system, permease F0335_RS12545 ENOG4108IJ9 (ABC) transporter F0335_RS12550 ENOG4105DDC Oxidoreductase domain protein F0335_RS12555 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) F0335_RS12560 ENOG4105E98 transcriptional regulator DeoR family F0335_RS12565 ENOG4105E70 isomerase F0335_RS12570 ENOG4105D2N Aldolase F0335_RS12580 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F0335_RS12585 ENOG4105DS0 Transcriptional regulator, Crp Fnr family F0335_RS12590 ENOG4105Q9Y Universal stress protein F0335_RS12595 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F0335_RS12600 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F0335_RS12605 ENOG4105C5D exported protein F0335_RS12610 ENOG4105D5Q Arginine ornithine antiporter F0335_RS12630 ENOG410642E Short chain dehydrogenase F0335_RS12635 ENOG4107EXC regulatoR F0335_RS12640 ENOG4105JJR Histidine kinase F0335_RS12645 ENOG4105CTD carboxy-peptidase F0335_RS12660 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap F0335_RS12665 ENOG4105E7U AraC family transcriptional regulator F0335_RS12670 ENOG4105CBK multidrug resistance protein F0335_RS12675 ENOG4105CQ7 ATP-dependent helicase F0335_RS12680 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) F0335_RS12685 ENOG4105WXT Conserved Protein F0335_RS12690 ENOG410689M (LipO)protein F0335_RS12695 ENOG4107H52 Dicarboxylate transport F0335_RS12700 ENOG4105EGI Transcriptional regulator F0335_RS12710 ENOG4105C5I Dehydrogenase F0335_RS12715 ENOG41090X5 Heat shock protein hslJ F0335_RS12720 ENOG4105IKK cytoplasmic protein F0335_RS12730 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) F0335_RS12735 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) F0335_RS12765 ENOG4107QSI ABC, transporter F0335_RS12775 ENOG4105KXI murein peptide amidase A F0335_RS12780 ENOG4107S8C mandelate racemase muconate lactonizing F0335_RS12785 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) F0335_RS12795 ENOG4106K28 UPF0283 membrane protein F0335_RS12800 ENOG4105CM6 amino acid regulated cytosolic protein F0335_RS12805 ENOG4105NNG Peripheral inner membrane phage-shock protein F0335_RS12810 ENOG4105FM1 phage shock protein C F0335_RS12815 ENOG4105YYT phage shock protein B F0335_RS12820 ENOG41087YS Phage shock protein A F0335_RS12825 ENOG4105E51 psp operon transcriptional activator F0335_RS12830 ENOG4106UW1 Major Facilitator superfamily F0335_RS12835 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr F0335_RS12850 ENOG4107UHU Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) F0335_RS12855 ENOG4108J59 Extracellular solute-binding protein, family 5 F0335_RS12860 ENOG4108EKA peptide transport system, permease F0335_RS12865 ENOG4108EU3 peptide transport system, permease F0335_RS12870 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein F0335_RS12875 ENOG4108JQ2 peptide transport system atp-binding protein F0335_RS12885 ENOG4105Q4T oxidoreductase F0335_RS12895 ENOG4105DUM transcriptional regulator, lysR family F0335_RS12900 ENOG4105DZ1 carboxypeptidase F0335_RS12905 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit F0335_RS12920 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) F0335_RS12930 ENOG4105CH2 amidohydrolase F0335_RS12935 ENOG4105D22 carbon starvation protein F0335_RS12940 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F0335_RS12945 ENOG4105F1A Pyruvate formate-lyase F0335_RS12955 ENOG4105N2W Transcriptional regulator F0335_RS12965 ENOG4108ZJT translation initiation factor, Sui1 F0335_RS12985 ENOG4105CFV Tetratricopeptide repeat protein F0335_RS12990 ENOG4105Q4A inner membrane protein yciS F0335_RS12995 ENOG4105EYK Phosphatidylglycerophosphatase B F0335_RS13005 ENOG4107QM5 aconitate hydratase F0335_RS13020 ENOG4107R11 Transcriptional regulator F0335_RS13025 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F0335_RS13030 ENOG4105RKX Protein of unknown function (DUF2498) F0335_RS13035 ENOG4105ERU peptidase F0335_RS13040 ENOG4105UBK short-chain dehydrogenase reductase F0335_RS13045 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase F0335_RS13050 ENOG4105FE9 pseudouridine synthase F0335_RS13065 ENOG4107RTD sua5 ycio yrdc ywlc family protein F0335_RS13070 ENOG4105DB7 PHP domain protein F0335_RS13085 ENOG4107QYG anthranilate phosphoribosyltransferase F0335_RS13090 ENOG4105DK0 Indole-3-glycerol phosphate synthase F0335_RS13095 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) F0335_RS13100 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) F0335_RS13110 ENOG4105EIF outer membrane protein W F0335_RS13115 ENOG4105PI0 Ferredoxin F0335_RS13120 ENOG4108S3I UPF0259 membrane protein F0335_RS13130 ENOG4107835 probably involved in intracellular septation (By similarity) F0335_RS13135 ENOG4105NAU thioesterase Superfamily protein F0335_RS13145 ENOG4105WPN DNA integration recombination invertion protein F0335_RS13150 ENOG4105K9H YciI-like protein F0335_RS13170 ENOG4107NQ8 LysR family Transcriptional regulator F0335_RS13180 ENOG4105ETE Transcriptional regulator (LacI family F0335_RS13195 ENOG4105CMG Carbohydrate kinase F0335_RS13200 ENOG4105C2J ABC transporter F0335_RS13205 ENOG4105CNN ABC, transporter F0335_RS13210 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F0335_RS13225 ENOG4108RMU ferritin dps family protein F0335_RS13235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F0335_RS13240 ENOG4108W5H UPF0263 protein F0335_RS13245 ENOG4108JQ7 (ABC) transporter F0335_RS13250 ENOG4105C3U ABC transporter F0335_RS13255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F0335_RS13260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F0335_RS13265 ENOG4107QSI ABC, transporter F0335_RS13270 ENOG4108J59 Extracellular solute-binding protein, family 5 F0335_RS13275 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein F0335_RS13280 ENOG4105C0A alcohol dehydrogenase F0335_RS13300 ENOG4105C6Y Udp-glucose 6-dehydrogenase F0335_RS13305 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F0335_RS13310 ENOG4105I93 response regulator F0335_RS13315 ENOG4105D78 K07001 NTE family protein F0335_RS13320 ENOG4105K5B UPF0225 protein F0335_RS13325 ENOG4105CIY formyltetrahydrofolate deformylase F0335_RS13355 ENOG4108URH decarboxylase F0335_RS13360 ENOG4105CGK Exodeoxyribonuclease III F0335_RS13365 ENOG4105M6F mutator MutT protein F0335_RS13370 ENOG4105MTM Protein of unknown function (DUF1496) F0335_RS13375 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F0335_RS13380 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) F0335_RS13390 ENOG41069NU Nitroreductase F0335_RS13395 ENOG4105D07 Signal peptide peptidase, SppA F0335_RS13400 ENOG4105HDK L-asparaginase F0335_RS13405 ENOG4108RWI nicotinamidase F0335_RS13415 ENOG4105VUT cytoplasmic protein F0335_RS13420 ENOG4105E0X reductase F0335_RS13425 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F0335_RS13430 ENOG4105DSB aldose 1-epimerase F0335_RS13435 ENOG4105GNX MltA-interacting MipA family protein F0335_RS13450 ENOG4106AKX UPF0229 protein F0335_RS13490 ENOG4105CNH Multidrug resistance protein MdtL F0335_RS13495 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F0335_RS13500 ENOG4105MWK D-amino acid dehydrogenase, small subunit F0335_RS13510 ENOG4108MEK Metal-binding protein YodA F0335_RS13515 ENOG4105ED1 spovr family F0335_RS13520 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) F0335_RS13525 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) F0335_RS13530 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) F0335_RS13535 ENOG4108ZZ3 UPF0260 protein F0335_RS13540 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase F0335_RS13545 ENOG4105CVE Lytic murein transglycosylase F0335_RS13550 ENOG4105VNG YcgL domain-containing protein F0335_RS13555 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) F0335_RS13560 ENOG4107QMS site-determining protein F0335_RS13565 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) F0335_RS13570 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) F0335_RS13575 ENOG4105CEY Amp-dependent synthetase and ligase F0335_RS13580 ENOG4105Y4Z Outer Membrane Lipoprotein F0335_RS13585 ENOG41072GX Peptidase M22 Glycoprotease F0335_RS13590 ENOG4105DVT helicase F0335_RS13595 ENOG4105M4H endoribonuclease L-psp F0335_RS13600 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) F0335_RS13605 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) F0335_RS13610 ENOG4108UHU Aldolase F0335_RS13615 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F0335_RS13620 ENOG4106KNT transcriptional regulator F0335_RS13625 ENOG4105CA9 Pyruvate kinase F0335_RS13635 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase F0335_RS13640 ENOG4105DR5 peptidase F0335_RS13645 ENOG4105NXV High-affinity zinc uptake system protein F0335_RS13650 ENOG4105FDK ABC transporter F0335_RS13655 ENOG4105FAV ABC, transporter F0335_RS13660 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) F0335_RS13665 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) F0335_RS13670 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) F0335_RS13675 ENOG4105CDY transcriptional regulatory protein F0335_RS13680 ENOG4108TIT dATP pyrophosphohydrolase F0335_RS13685 ENOG4105C9M aspartyl-trna synthetase F0335_RS13695 ENOG4105D3W isochorismatase F0335_RS13700 ENOG41081XQ Conserved Protein F0335_RS13705 ENOG4105WJG Glutathione F0335_RS13710 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) F0335_RS13715 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) F0335_RS13720 ENOG4108V1T peptidylprolyl cis-trans isomerase F0335_RS13730 ENOG4106N3A copper homeostasis protein cutc F0335_RS13735 ENOG4105C87 Aminotransferase class I and II F0335_RS13740 ENOG4106ZCM YecM protein F0335_RS13745 ENOG4105C75 arginyL-tRNA synthetase F0335_RS13750 ENOG4105CJR Integral membrane protein (MviN F0335_RS13755 ENOG4105EP9 oxidoreductase F0335_RS13760 ENOG4108YXG UPF0502 protein F0335_RS13765 ENOG4105D9U N-acetyltransferase F0335_RS13770 ENOG4105EV4 Multidrug resistance protein mdtH F0335_RS13780 ENOG4105E9S glutaredoxin 2 F0335_RS13785 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) F0335_RS13790 ENOG4105F3T (LipO)protein F0335_RS13800 ENOG4105N5Z UPF0267 protein F0335_RS13805 ENOG4105X2V dna damage-inducible protein F0335_RS13810 ENOG4105C1J atp-dependent rna helicase F0335_RS13820 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR F0335_RS13825 ENOG4105X5C UPF0181 protein F0335_RS13840 ENOG4105P8F nudix hydrolase F0335_RS13845 ENOG4105EJQ L-serine dehydratase F0335_RS13850 ENOG4107XTP (EAL) domain protein F0335_RS13855 ENOG4105EE5 Membrane protein terC F0335_RS13860 ENOG4105DAS pts system F0335_RS13865 ENOG4105ETZ PTS System F0335_RS13870 ENOG4105F3R pts system mannose fructose sorbose family iid F0335_RS13875 ENOG4108NK4 UPF0266 membrane protein F0335_RS13880 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) F0335_RS13885 ENOG4105DHI Methyltransferase F0335_RS13890 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F0335_RS13915 ENOG4105C85 amino acid F0335_RS13935 ENOG41064PC F0335_RS13945 ENOG4105TIK F0335_RS13950 ENOG4105N4N Protein of unknown function (DUF2766) F0335_RS13955 ENOG4105XH3 F0335_RS13970 ENOG4105EUB pirin domain protein F0335_RS13985 ENOG4109066 lysm domain bon superfamily protein F0335_RS13990 ENOG4105UVW uncharacterized protein yebW F0335_RS14005 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) F0335_RS14010 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) F0335_RS14015 ENOG4105C26 Dehydrogenase F0335_RS14020 ENOG4105F4X arginine F0335_RS14025 ENOG4105C8Y Acetylornithine aminotransferase F0335_RS14035 ENOG4108JQ7 (ABC) transporter F0335_RS14040 ENOG4105C3U ABC transporter F0335_RS14060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0335_RS14065 ENOG4105C4M (Ubiquinol oxidase) subunit I F0335_RS14070 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F0335_RS14120 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase F0335_RS14125 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F0335_RS14130 ENOG41076YT nitrate reductase, gamma subunit F0335_RS14135 ENOG4105R3A Nitrate reductase F0335_RS14140 ENOG4108IUE nitrate reductase beta subunit F0335_RS14145 ENOG4105CRU nitrate reductase, alpha subunit F0335_RS14160 ENOG4105CG5 Glycosyl transferase (Group 1 F0335_RS14185 ENOG4105D75 Capsular exopolysaccharide family F0335_RS14190 ENOG4105DAY polysaccharide export protein F0335_RS14195 ENOG4105ESV Glycosyl transferase, family 4 F0335_RS14200 ENOG4105DMT epimerase dehydratase F0335_RS14205 ENOG4108M3R transcriptional activator CadC F0335_RS14215 ENOG4105BZU Histidine kinase F0335_RS14220 ENOG4105WH1 Two component transcriptional regulator luxr family F0335_RS14225 ENOG4105ID0 Putative invasin F0335_RS14230 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) F0335_RS14240 ENOG4105DEF Extracellular solute-binding protein, family 5 F0335_RS14245 ENOG4108JQ7 (ABC) transporter F0335_RS14250 ENOG4105C3U ABC transporter F0335_RS14255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F0335_RS14260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F0335_RS14270 ENOG4107R11 Transcriptional regulator F0335_RS14275 ENOG4108NH8 Cation transport protein F0335_RS14280 ENOG4105WS7 Cation transport regulator F0335_RS14285 ENOG4105Q26 Siderophore-interacting protein F0335_RS14290 ENOG4105EWV Sodium calcium exchanger membrane region F0335_RS14300 ENOG4105D5M phosphate starvation-inducible protein F0335_RS14310 ENOG410650H (LipO)protein F0335_RS14315 ENOG4105EKT )-iron permease F0335_RS14320 ENOG4105CK7 Sodium proline symporter F0335_RS14325 ENOG4105C26 Dehydrogenase F0335_RS14330 ENOG4105CDA abc transporter atp-binding protein F0335_RS14335 ENOG4105E5Q amino acid AbC transporter F0335_RS14340 ENOG4105EAB amino acid AbC transporter F0335_RS14345 ENOG4105K6H D-cysteine desulfhydrase F0335_RS14350 ENOG4108M9K flagella biosynthesis protein FliZ F0335_RS14355 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0335_RS14365 ENOG4105DTS flagellar hook-associated F0335_RS14370 ENOG4105MQ3 flagellar protein FliS F0335_RS14375 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) F0335_RS14385 ENOG4105CC0 LysR family Transcriptional regulator F0335_RS14400 ENOG4105VQ0 flagellar hook-basal body complex protein fliE F0335_RS14405 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) F0335_RS14410 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F0335_RS14415 ENOG41090PJ Flagellar assembly protein F0335_RS14420 ENOG4108JIR Flagellum-specific ATP synthase F0335_RS14425 ENOG4105GSA Flagellar export protein flij F0335_RS14430 ENOG4105WF4 Flagellar hook-length control protein F0335_RS14435 ENOG4107ZI8 flagellar basal body-associated protein flil F0335_RS14440 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F0335_RS14445 ENOG4105DD5 Flagellar motor switch protein F0335_RS14455 ENOG4105CN7 Flagellar biosynthetic protein FliP F0335_RS14460 ENOG4105VS8 Flagellar biosynthetic protein fliq F0335_RS14465 ENOG4105D19 Role in flagellar biosynthesis (By similarity) F0335_RS14475 ENOG4105DTJ flagellar hook-associated protein F0335_RS14480 ENOG4105E1Q flagellar hook-associated protein F0335_RS14485 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj F0335_RS14500 ENOG4105CGA flagellar basal-body rod protein FlgG F0335_RS14505 ENOG4108KPB Flagellar basal-body rod protein FlgF F0335_RS14510 ENOG4105BZE flagellar hook protein, FlgE F0335_RS14515 ENOG4105W00 Flagellar hook capping protein F0335_RS14520 ENOG4108ZC9 flagellar basal-body rod protein flgc F0335_RS14530 ENOG4105CKS Flagella basal body P-ring formation protein flgA F0335_RS14535 ENOG4105M9M anti-sigma28 factor FlgM F0335_RS14540 ENOG4105QVD Flagella synthesis protein FlgN F0335_RS14560 ENOG4105D7B Flagellar biosynthesis protein flha F0335_RS14565 ENOG4105D00 flagellar biosynthetic protein flhB F0335_RS14570 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) F0335_RS14575 ENOG4108VYJ response regulator receiver protein F0335_RS14585 ENOG4105BZU Histidine kinase F0335_RS14590 ENOG4105C8Q Methyl-accepting chemotaxis F0335_RS14595 ENOG4105C8Q Methyl-accepting chemotaxis F0335_RS14600 ENOG4108V3W Chemotaxis protein, CheW F0335_RS14605 ENOG4105CBS Chea signal transduction histidine kinase F0335_RS14610 ENOG4105ER2 Ompa motb domain protein F0335_RS14615 ENOG4107RD7 Flagellar Motor Protein, MotA F0335_RS14635 ENOG4105QZ5 OriC-binding nucleoid-associated protein F0335_RS14640 ENOG4108VA4 Universal stress protein F0335_RS14645 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein F0335_RS14710 ENOG4106VK6 Flagellar motor protein F0335_RS14755 ENOG4108WC9 type VI secretion system effector, hcp1 family F0335_RS14810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F0335_RS14820 ENOG4105CS6 Rhs element vgr protein F0335_RS14830 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) F0335_RS14835 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) F0335_RS14840 ENOG4107QN2 dihydrolipoyl dehydrogenase F0335_RS14850 ENOG4108KBJ Inner membrane protein YkgB F0335_RS14855 ENOG4108K01 transcriptional regulator F0335_RS14860 ENOG4105ETE Transcriptional regulator (LacI family F0335_RS14890 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) F0335_RS14895 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F0335_RS14905 ENOG4108S3W Anti-feci sigma factor, fecr F0335_RS14910 ENOG4108SF5 RNA Polymerase F0335_RS14915 ENOG4105X58 receptor F0335_RS14920 ENOG4105KT5 UmuD protein F0335_RS14945 ENOG4105FFC UPF0187 protein F0335_RS14950 ENOG4105EZR dyp-type peroxidase family protein F0335_RS14970 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) F0335_RS14990 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic F0335_RS14995 ENOG4105KT7 mgtC SapB transporter F0335_RS15010 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F F0335_RS15015 ENOG4108MGI Transcriptional regulator F0335_RS15020 ENOG4105DY8 decarboxylase F0335_RS15035 ENOG4105VZF DsrB protein F0335_RS15065 ENOG410642W LysR family Transcriptional regulator F0335_RS15070 ENOG4105VP5 Bacterial protein of unknown function (DUF937) F0335_RS15075 ENOG4105Y3U Transglycosylase-associated protein F0335_RS15085 ENOG4105D1S lipid A biosynthesis F0335_RS15090 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase F0335_RS15110 ENOG4105DXM phenylacetic acid degradation protein F0335_RS15115 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit F0335_RS15120 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit F0335_RS15125 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit F0335_RS15130 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit F0335_RS15135 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F0335_RS15140 ENOG4105E39 Enoyl-CoA hydratase F0335_RS15145 ENOG4108UKI Enoyl-CoA hydratase F0335_RS15150 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F0335_RS15155 ENOG4108ZJI phenylacetic acid degradation protein F0335_RS15160 ENOG4105CHU acetyl-coa acetyltransferase F0335_RS15165 ENOG4105DZS Phenylacetate-CoA ligase F0335_RS15170 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein F0335_RS15175 ENOG4108Z0R Transferase F0335_RS15190 ENOG4105C85 amino acid F0335_RS15195 ENOG4105CGF Aromatic amino acid aminotransferase F0335_RS15210 ENOG4105CC0 LysR family Transcriptional regulator F0335_RS15230 ENOG4105C26 Dehydrogenase F0335_RS15250 ENOG4105EQ2 LysR family Transcriptional regulator F0335_RS15255 ENOG4105CPC Aldo Keto reductase F0335_RS15260 ENOG4105CHB tonB-dependent Receptor F0335_RS15265 ENOG4105DZG Dehydrogenase F0335_RS15300 ENOG4105UGQ Fimbrial F0335_RS15310 ENOG4108FZ9 Chaperone F0335_RS15315 ENOG4106PG1 outer membrane usher protein F0335_RS15320 ENOG4108RQP Major type 1 subunit fimbrin F0335_RS15340 ENOG4105UQX Mate efflux family protein F0335_RS15345 ENOG4105XQF Lipoprotein F0335_RS15370 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) F0335_RS15400 ENOG4105ETU transcriptional activator (TenA F0335_RS15405 ENOG4108YI8 ABC transporter F0335_RS15410 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component F0335_RS15415 ENOG4107Z6I Thiamine biosynthesis protein F0335_RS15425 ENOG4107RES phosphoglycerol transferase I F0335_RS15430 ENOG4105FYV Amp nucleosidase F0335_RS15450 ENOG4108T9Y Inner membrane protein ydcZ F0335_RS15455 ENOG4108Z7F N-acetyltransferase F0335_RS15465 ENOG410900S Protein of unknown function (DUF2623) F0335_RS15475 ENOG4105W8I Transcriptional regulator F0335_RS15485 ENOG4105DKP glycosyl transferase, family 9 F0335_RS15505 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F0335_RS15510 ENOG4105EXG Transcriptional regulator F0335_RS15515 ENOG4105CF1 Alkylated DNA repair protein F0335_RS15520 ENOG4105DTR rard protein F0335_RS15525 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase F0335_RS15530 ENOG4105E4F Isochorismate synthase F0335_RS15540 ENOG4105D6F Phosphatase F0335_RS15545 ENOG4107QPK )-transporter F0335_RS15550 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase F0335_RS15560 ENOG4105CHY citrate lyase, alpha F0335_RS15565 ENOG4105CI0 Citrate lyase F0335_RS15570 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) F0335_RS15575 ENOG4105DUA (citrate (pro-3S)-lyase ligase F0335_RS15585 ENOG4105CNT hydrolase family 2 F0335_RS15595 ENOG4105E1F short-chain dehydrogenase reductase F0335_RS15600 ENOG4105CF7 AraC family transcriptional regulator F0335_RS15610 ENOG4105CPC Aldo Keto reductase F0335_RS15615 ENOG4105ENX hydrolase F0335_RS15630 ENOG4105EQ2 LysR family Transcriptional regulator F0335_RS15640 ENOG4105ETT transcriptional Regulator, LysR family F0335_RS15655 ENOG4105DIK (ABC) transporter F0335_RS15660 ENOG4105EHG Permease protein F0335_RS15675 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0335_RS15680 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase F0335_RS15695 ENOG4107RGH Aldehyde dehydrogenase F0335_RS15700 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) F0335_RS15725 ENOG4105EA8 2-Nitropropane dioxygenase F0335_RS15745 ENOG4105C54 Major Facilitator superfamily F0335_RS15770 ENOG4108IV0 ABC, transporter F0335_RS15775 ENOG4105C0Z ABC transporter F0335_RS15780 ENOG4105CF8 branched-chain amino acid ABC transporter, permease F0335_RS15785 ENOG4105C32 Amino acid ABC transporter (Permease) F0335_RS15805 ENOG4105ENX hydrolase F0335_RS15810 ENOG4105ENX hydrolase F0335_RS15815 ENOG4105EQ2 LysR family Transcriptional regulator F0335_RS15835 ENOG4105CSH Transporter F0335_RS15845 ENOG4105F04 LysR family Transcriptional regulator F0335_RS15850 ENOG41080IJ Diacylglycerol kinase F0335_RS15870 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F0335_RS15875 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F0335_RS15880 ENOG4108GH0 ATP-binding protein yghT F0335_RS15885 ENOG4108NDC ATP-binding protein yghS F0335_RS15890 ENOG4106FPV ATP-binding protein YghR F0335_RS15895 ENOG4108S55 polysaccharide biosynthesis protein F0335_RS15905 ENOG4108UUE Transcriptional regulator F0335_RS15910 ENOG4108M8S permease YjgP YjgQ family protein F0335_RS15935 ENOG410810E transcriptional regulator, lysR family F0335_RS15950 ENOG4105FKQ transcriptional regulator F0335_RS15955 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase F0335_RS15960 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase F0335_RS15965 ENOG4105CMG Carbohydrate kinase F0335_RS15970 ENOG4105CNN ABC, transporter F0335_RS15980 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F0335_RS15985 ENOG4105CPQ Dehydrogenase F0335_RS15995 ENOG4105CH2 amidohydrolase F0335_RS16000 ENOG4105E89 ABC transporter F0335_RS16005 ENOG41090HJ UPF0265 protein F0335_RS16010 ENOG4105DR8 Membrane F0335_RS16015 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase F0335_RS16040 ENOG4105CJB Exodeoxyribonuclease I F0335_RS16045 ENOG4105CUB amino acid F0335_RS16050 ENOG4105CFQ glutamine synthetase F0335_RS16055 ENOG4107VRI Transcriptional regulator F0335_RS16060 ENOG4105C2J ABC transporter F0335_RS16065 ENOG4105CNN ABC, transporter F0335_RS16070 ENOG4105D05 Receptor F0335_RS16085 ENOG4105EHG Permease protein F0335_RS16090 ENOG4105BZU Histidine kinase F0335_RS16095 ENOG4108IQI permease F0335_RS16100 ENOG4105DUM transcriptional regulator, lysR family F0335_RS16110 ENOG4105HMI Membrane F0335_RS16115 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) F0335_RS16125 ENOG4105DM4 PTS System F0335_RS16130 ENOG4105DE4 1-phosphofructokinase F0335_RS16135 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein F0335_RS16140 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F0335_RS16145 ENOG4105CUW cytochrome C-TYPE protein F0335_RS16150 ENOG4107QY8 reductase F0335_RS16160 ENOG4105KRS Proteinase inhibitor F0335_RS16170 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) F0335_RS16175 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) F0335_RS16180 ENOG4105DEI Mannitol dehydrogenase F0335_RS16190 ENOG4105CKI cobalamin synthesis protein F0335_RS16195 ENOG41076MN Phosphoesterase, PA-phosphatase related F0335_RS16200 ENOG4107TT5 NLP P60 protein F0335_RS16205 ENOG4105CXC rtn protein F0335_RS16210 ENOG4105E43 Extracellular solute-binding protein, family 5 F0335_RS16215 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component F0335_RS16220 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component F0335_RS16225 ENOG4108JQ5 ABC transporter F0335_RS16230 ENOG4105HG6 F0335_RS16235 ENOG4105C2C drug resistance transporter, Bcr CflA F0335_RS16240 ENOG4105I08 Pseudouridine synthase F0335_RS16245 ENOG4105CFI type iii restriction protein res subunit F0335_RS16250 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) F0335_RS16255 ENOG4106V8H Nucleoid-associated protein F0335_RS16260 ENOG4105PAN UPF0352 protein F0335_RS16265 ENOG4105E68 Sulfatase F0335_RS16280 ENOG4105DB1 molybdopterin oxidoreductase F0335_RS16285 ENOG4106WHD Tetrathionate reductase F0335_RS16295 ENOG4106AFQ Histidine kinase F0335_RS16305 ENOG4105Y50 Virulence Protein F0335_RS16310 ENOG4108X9F tail fiber protein F0335_RS16395 ENOG4105KUS lysozyme F0335_RS16405 ENOG4105HRS Antitermination protein F0335_RS16425 ENOG4105KKI DNA-binding transcriptional activator OsmE F0335_RS16440 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) F0335_RS16450 ENOG4105M0C cytoplasmic protein F0335_RS16455 ENOG4106UW1 Major Facilitator superfamily F0335_RS16460 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC F0335_RS16470 ENOG4105BZU Histidine kinase F0335_RS16475 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0335_RS16480 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) F0335_RS16485 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F0335_RS16490 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F0335_RS16495 ENOG4105XPH Ferredoxin F0335_RS16520 ENOG4105E0U tyrosine-specific transport protein F0335_RS16525 ENOG4108UII YfaZ family F0335_RS16530 ENOG4105CH6 catalase F0335_RS16535 ENOG4105CEY Amp-dependent synthetase and ligase F0335_RS16545 ENOG4108IPT Naphthoate synthase F0335_RS16550 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) F0335_RS16555 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) F0335_RS16560 ENOG4105TNS Conserved Protein F0335_RS16570 ENOG4105CHR reductase F0335_RS16575 ENOG4105K2J Transcriptional regulator F0335_RS16580 ENOG4108UQ5 membrane protein YcdZ F0335_RS16605 ENOG4105C7K acetolactate synthase F0335_RS16610 ENOG4105HEI LysR family (Transcriptional regulator F0335_RS16615 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0335_RS16620 ENOG4105C8S subunit m F0335_RS16625 ENOG4105D65 subunit l F0335_RS16630 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0335_RS16635 ENOG4107UFS subunit j F0335_RS16645 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) F0335_RS16650 ENOG4108IEH NADH dehydrogenase subunit g F0335_RS16655 ENOG4107QIZ NADH dehydrogenase F0335_RS16660 ENOG4105GKE subunit e F0335_RS16665 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0335_RS16670 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0335_RS16675 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F0335_RS16680 ENOG4107NQ8 LysR family Transcriptional regulator F0335_RS16685 ENOG4105CHM Aminotransferase F0335_RS16690 ENOG4105DK2 UPF0207 protein F0335_RS16695 ENOG4107QWE )-transporter F0335_RS16700 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 F0335_RS16705 ENOG4105XWI UPF0304 protein F0335_RS16710 ENOG4105PQ6 UPF0208 membrane protein F0335_RS16715 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F0335_RS16720 ENOG4105C6K Malic enzyme F0335_RS16740 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) F0335_RS16745 ENOG4108HHA Transketolase F0335_RS16750 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC F0335_RS16760 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia F0335_RS16765 ENOG4105K2J Transcriptional regulator F0335_RS16770 ENOG4105PTV Nudix Hydrolase F0335_RS16775 ENOG4108RE9 Phosphodiesterase F0335_RS16780 ENOG4105CYM Glutathione S-transferase F0335_RS16785 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase F0335_RS16790 ENOG4105ECP epimerase F0335_RS16795 ENOG4108JEH abc transporter atp-binding protein F0335_RS16800 ENOG4106YG3 ABC transporter F0335_RS16805 ENOG4105DSP amino acid AbC transporter F0335_RS16810 ENOG4105E89 ABC transporter F0335_RS16815 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase F0335_RS16820 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase F0335_RS16825 ENOG4105E96 Colicin v production protein F0335_RS16830 ENOG4108S3P Sporulation domain protein F0335_RS16835 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F0335_RS16840 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) F0335_RS16845 ENOG4105DQR SNARE associated Golgi F0335_RS16855 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F0335_RS16860 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) F0335_RS16870 ENOG410631K Membrane F0335_RS16875 ENOG4105DHQ Histidine kinase F0335_RS16905 ENOG4105EQK -acetyltransferase F0335_RS16915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0335_RS16920 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F0335_RS16930 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) F0335_RS16940 ENOG4106WZ1 flagella biosynthesis regulator F0335_RS16960 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) F0335_RS16975 ENOG4105XCM membrane LIPOPROTEIN F0335_RS16980 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F0335_RS16990 ENOG4105MH2 YfcL protein F0335_RS16995 ENOG4108BPE -transporting atpase F0335_RS17000 ENOG4105EJ9 Membrane F0335_RS17005 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) F0335_RS17010 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase F0335_RS17015 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) F0335_RS17020 ENOG4108DG9 Smr protein MutS2 F0335_RS17025 ENOG4108BY2 phosphohistidine phosphatase F0335_RS17030 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F0335_RS17035 ENOG4105CHU acetyl-coa acetyltransferase F0335_RS17040 ENOG4105KZW UPF0381 protein F0335_RS17045 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation F0335_RS17050 ENOG410903C (LipO)protein F0335_RS17055 ENOG4105KWW Biogenesis protein F0335_RS17060 ENOG4105KWW Biogenesis protein F0335_RS17065 ENOG4107QX9 Thiol disulfide interChange protein F0335_RS17070 ENOG4105DA4 cytochrome c-type biogenesis protein F0335_RS17075 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) F0335_RS17080 ENOG4105X3C heme exporter protein F0335_RS17085 ENOG41060IM Heme exporter protein F0335_RS17090 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) F0335_RS17100 ENOG4105S64 Formate nitrite transporter F0335_RS17115 ENOG4105UEI Transcriptional Regulator AraC Family F0335_RS17130 ENOG4105WH1 Two component transcriptional regulator luxr family F0335_RS17150 ENOG4105W8I Transcriptional regulator F0335_RS17160 ENOG4108Q5Y Membrane F0335_RS17175 ENOG4105CVE Lytic murein transglycosylase F0335_RS17185 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin F0335_RS17195 ENOG4108VKM cytochrome b561 F0335_RS17200 ENOG4105CHM Aminotransferase F0335_RS17210 ENOG41072TH Protein of unknown function (DUF1479) F0335_RS17220 ENOG4105DY9 regulatoR F0335_RS17225 ENOG41062C6 Protein of unknown function (DUF2502) F0335_RS17230 ENOG4105FCD Major Facilitator F0335_RS17255 ENOG4105CR8 Transcriptional regulator F0335_RS17260 ENOG4107RA9 decarboxylase F0335_RS17265 ENOG4105CPC Aldo Keto reductase F0335_RS17275 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) F0335_RS17280 ENOG4105D9N nucleoside F0335_RS17295 ENOG4105TMB Formate nitrite transporter F0335_RS17300 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) F0335_RS17330 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein F0335_RS17335 ENOG4105DQ5 transport system permease protein F0335_RS17340 ENOG4105TVJ transport system, permease F0335_RS17345 ENOG4105E0A ABC, transporter F0335_RS17350 ENOG4105DEF Extracellular solute-binding protein, family 5 F0335_RS17355 ENOG4105C7K acetolactate synthase F0335_RS17370 ENOG4107FQ9 ethanolamine ammonia-lyase F0335_RS17375 ENOG4105CPD ethanolamine ammonia-lyase F0335_RS17390 ENOG4108M0I Transcriptional regulator F0335_RS17395 ENOG4105DHU Bile acid F0335_RS17400 ENOG4105VRT cytoplasmic protein F0335_RS17405 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) F0335_RS17410 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) F0335_RS17415 ENOG4105EXN Sulfate transport protein CysZ F0335_RS17420 ENOG4105C6T cysteine synthase F0335_RS17430 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F0335_RS17435 ENOG4105C5Y PTS System F0335_RS17440 ENOG4105E0F Histidine kinase F0335_RS17445 ENOG4105E3W Two component transcriptional regulator (Winged helix family F0335_RS17450 ENOG4105C6T cysteine synthase F0335_RS17460 ENOG4105ECW sulfate abc transporter F0335_RS17465 ENOG4108I5D sulfate abc transporter F0335_RS17470 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein F0335_RS17475 ENOG4105EZR dyp-type peroxidase family protein F0335_RS17480 ENOG4105E7K (LipO)protein F0335_RS17485 ENOG4105QZU Inner membrane protein YfeZ F0335_RS17490 ENOG4105H4F exported protein F0335_RS17495 ENOG4108R6G acetyltransferase F0335_RS17500 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase F0335_RS17505 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) F0335_RS17510 ENOG4108UPT UPF0178 protein F0335_RS17520 ENOG4105CUG Oligopeptidase b F0335_RS17535 ENOG4108IQI permease F0335_RS17540 ENOG4107QK5 Homocysteine s-methyltransferase F0335_RS17545 ENOG4105C6K Malic enzyme F0335_RS17570 ENOG4105EQ1 Transcriptional regulator F0335_RS17575 ENOG4108M1A Chitin-binding protein F0335_RS17580 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F0335_RS17585 ENOG4105CV1 Transketolase (EC 2.2.1.1) F0335_RS17590 ENOG4107VIJ nudix hydrolase F0335_RS17595 ENOG4105BZU Histidine kinase F0335_RS17600 ENOG4105WH1 Two component transcriptional regulator luxr family F0335_RS17610 ENOG4105BZS acriflavin resistance protein F0335_RS17630 ENOG4105VEV -acetyltransferase F0335_RS17640 ENOG4105KUZ arsenate reductase F0335_RS17645 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) F0335_RS17655 ENOG4105XYK UPF0370 protein F0335_RS17660 ENOG4106KED esterase YpfH F0335_RS17670 ENOG4105CGZ zinc metallopeptidase F0335_RS17675 ENOG4105C8V SAICAR synthetase F0335_RS17680 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F0335_RS17685 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F0335_RS17690 ENOG4105RH4 Glycine cleavage system transcriptional repressor F0335_RS17695 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F0335_RS17700 ENOG4105C02 permease F0335_RS17715 ENOG4108NS2 receptor F0335_RS17735 ENOG4105EW9 transcriptional regulator AsnC family F0335_RS17750 ENOG4105ERG peptidase m48, ste24p F0335_RS17755 ENOG4105K89 arsenate reductase F0335_RS17765 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) F0335_RS17775 ENOG4105Y3U Transglycosylase-associated protein F0335_RS17785 ENOG4105C2W permease F0335_RS17790 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) F0335_RS17795 ENOG4105CXB phosphoribosylaminoimidazole synthetase F0335_RS17800 ENOG4108V3E phosphoribosylglycinamide formyltransferase F0335_RS17805 ENOG4108MK9 spermidine N(1)-acetyltransferase F0335_RS17825 ENOG4105C8U phosphate abc transporter F0335_RS17830 ENOG4105C8U phosphate abc transporter F0335_RS17835 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) F0335_RS17840 ENOG4105C9X ppx gppa phosphatase F0335_RS17850 ENOG4105CJW magnesium transporter F0335_RS17855 ENOG4105BZU Histidine kinase F0335_RS17870 ENOG4105R8A Heat shock protein F0335_RS17885 ENOG4105CPC Aldo Keto reductase F0335_RS17890 ENOG4105ENT Efflux transporter rnd family, mfp subunit F0335_RS17895 ENOG4105BZS acriflavin resistance protein F0335_RS17900 ENOG4105BZS acriflavin resistance protein F0335_RS17905 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0335_RS17910 ENOG4105EB3 Histidine kinase F0335_RS17915 ENOG4105E3W Two component transcriptional regulator (Winged helix family F0335_RS17930 ENOG4105KWI UPF0339 protein F0335_RS17935 ENOG4105CFP Peptidase U32 F0335_RS17940 ENOG4107TE5 Lipid kinase F0335_RS17945 ENOG4105CXK mandelate racemase muconate lactonizing F0335_RS17950 ENOG4105CPQ Dehydrogenase F0335_RS17955 ENOG4108I5G Major Facilitator superfamily F0335_RS17960 ENOG4105DEI Mannitol dehydrogenase F0335_RS17970 ENOG4107XBN GntR Family Transcriptional Regulator F0335_RS17975 ENOG4105EIE fructose-bisphosphate aldolase F0335_RS17985 ENOG410787A Pts system, glucitol sorbitol-specific F0335_RS17990 ENOG4105DZY Pts system, glucitol sorbitol-specific F0335_RS17995 ENOG4105VI0 Pts system, glucitol sorbitol-specific F0335_RS18000 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase F0335_RS18005 ENOG4105J92 DNA-binding transcriptional activator GutM F0335_RS18010 ENOG410804X Transcriptional regulator F0335_RS18020 ENOG4108ZGU inhibitor of vertebrate lysozyme F0335_RS18025 ENOG4105DWF phosphomethylpyrimidine kinase F0335_RS18030 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase F0335_RS18065 ENOG4105FE9 pseudouridine synthase F0335_RS18085 ENOG4105BZU Histidine kinase F0335_RS18095 ENOG4105KVH Transcriptional regulator F0335_RS18160 ENOG4105DFP Integrase F0335_RS18165 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F0335_RS18170 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F0335_RS18175 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) F0335_RS18185 ENOG4105DPW Major facilitator superfamily MFS_1 F0335_RS18190 ENOG4105ETE Transcriptional regulator (LacI family F0335_RS18195 ENOG4105D4Y metalloprotease F0335_RS18205 ENOG4105VPD cellular component movement F0335_RS18215 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) F0335_RS18220 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F0335_RS18225 ENOG4105N21 Membrane F0335_RS18230 ENOG4105CUT histidyl-tRNA synthetase F0335_RS18235 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) F0335_RS18240 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) F0335_RS18250 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs F0335_RS18255 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) F0335_RS18260 ENOG4105YYA enhanced serine sensitivity protein SseB F0335_RS18265 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) F0335_RS18270 ENOG4105WVQ Fe-S assembly protein IscX F0335_RS18275 ENOG4108ZIT Ferredoxin, 2FE-2S F0335_RS18280 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB F0335_RS18285 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) F0335_RS18290 ENOG4108Z4V iron-sulfur cluster assembly F0335_RS18295 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins F0335_RS18300 ENOG4105C3J Cysteine desulfurase F0335_RS18305 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family F0335_RS18315 ENOG4105ECY inositol monophosphatase F0335_RS18320 ENOG4105D7X high-affinity nickel-transporter F0335_RS18325 ENOG41065CD Exported protein F0335_RS18335 ENOG4105D8G Major Facilitator superfamily F0335_RS18340 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) F0335_RS18345 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F0335_RS18360 ENOG4105C26 Dehydrogenase F0335_RS18365 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component F0335_RS18370 ENOG4105D81 ABC transporter, permease F0335_RS18375 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0335_RS18380 ENOG4107TYH extracellular solute-binding protein family 1 F0335_RS18385 ENOG4105C26 Dehydrogenase F0335_RS18390 ENOG4105C5Q Transcriptional regulator F0335_RS18395 ENOG4108YZA Nitrogen regulatory protein pii F0335_RS18400 ENOG4105C4K Nad synthetase F0335_RS18405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0335_RS18410 ENOG4108SKK alpha helix protein F0335_RS18415 ENOG4107WP9 Histidine kinase F0335_RS18425 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) F0335_RS18430 ENOG4108Z6B deaminase F0335_RS18440 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB F0335_RS18450 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate F0335_RS18455 ENOG4106G6Q Transcriptional regulator F0335_RS18550 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F0335_RS18585 ENOG4105NVB glycoside hydrolase, family 19 F0335_RS18645 ENOG4108S1U F0335_RS18715 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding F0335_RS18720 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) F0335_RS18725 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) F0335_RS18730 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) F0335_RS18735 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F0335_RS18740 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) F0335_RS18745 ENOG4105C3F Signal peptidase i F0335_RS18750 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) F0335_RS18760 ENOG4105WMJ Positive regulator of sigma E, RseC MucC F0335_RS18765 ENOG4105VQK sigma E regulatory protein, MucB RseB F0335_RS18780 ENOG4108IYU L-aspartate oxidase F0335_RS18785 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) F0335_RS18790 ENOG4105C1J atp-dependent rna helicase F0335_RS18810 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) F0335_RS18815 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ F0335_RS18820 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) F0335_RS18825 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F0335_RS18830 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F0335_RS18835 ENOG4105VDB UPF0125 protein F0335_RS18840 ENOG4108Z1B Cyclase dehydrase F0335_RS18845 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) F0335_RS18865 ENOG4105S5I Membrane F0335_RS18905 ENOG410830R acetyltransferase F0335_RS18910 ENOG4105VR1 Pfam:DUF1271 F0335_RS18915 ENOG4108SB3 DoxX Family F0335_RS18920 ENOG4108DG9 Smr protein MutS2 F0335_RS18930 ENOG4108SAJ Protein of unknown function (DUF1198) F0335_RS18935 ENOG4108WMJ Protein of unknown function (DUF2002) F0335_RS18940 ENOG4105F9N Major Facilitator Superfamily F0335_RS18955 ENOG4105JQN Transcriptional regulator F0335_RS18960 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0335_RS18975 ENOG4105TNS Conserved Protein F0335_RS18985 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F0335_RS18990 ENOG4105WAZ (Glutaredoxin-like protein) NrdH F0335_RS18995 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) F0335_RS19005 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F0335_RS19015 ENOG4105H9W Short-chain dehydrogenase reductase Sdr F0335_RS19025 ENOG4105Q2H domain protein F0335_RS19035 ENOG4105D2K citrate carrier protein F0335_RS19040 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F0335_RS19045 ENOG4106YYS transcriptional regulatory protein F0335_RS19055 ENOG4108IJ7 Glycine betaine F0335_RS19060 ENOG4108HQS Glycine betaine F0335_RS19065 ENOG4105GIJ Glycine betaine F0335_RS19070 ENOG4106NZI LysR family Transcriptional regulator F0335_RS19075 ENOG4105EQ0 Major Facilitator superfamily F0335_RS19080 ENOG4108UMN azlc family F0335_RS19085 ENOG4105ZED uncharacterized protein ygaH F0335_RS19090 ENOG4105NTK Transcriptional repressor Mpra F0335_RS19100 ENOG4105CW7 secretion protein, HlyD family F0335_RS19105 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0335_RS19110 ENOG4105EIB trna rrna methyltransferase F0335_RS19115 ENOG4105K63 Thioredoxin F0335_RS19120 ENOG4106IUH DTW domain containing protein F0335_RS19125 ENOG4105CD5 CoA-binding domain protein F0335_RS19130 ENOG4105JIM Phosphatidylserine synthase F0335_RS19135 ENOG4105CSH Transporter F0335_RS19160 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase F0335_RS19170 ENOG4108UMI ABC transporter, permease F0335_RS19175 ENOG4105D01 (LipO)protein F0335_RS19180 ENOG4108R8X outer membrane lipoprotein F0335_RS19185 ENOG4108R96 Methyltransferase, YaeB family F0335_RS19190 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) F0335_RS19195 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion F0335_RS19200 ENOG4108YZN class I peptide chain release factor F0335_RS19205 ENOG4108VWS Yaeq family F0335_RS19215 ENOG4105M1T rho-binding antiterminator F0335_RS19220 ENOG4105N7H Cytochrome F0335_RS19225 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) F0335_RS19230 ENOG4105DUX Transporter F0335_RS19235 ENOG4105CXN decarboxylase F0335_RS19240 ENOG4105D5Q Arginine ornithine antiporter F0335_RS19245 ENOG4108M3R transcriptional activator CadC F0335_RS19250 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase F0335_RS19255 ENOG4105CXN decarboxylase F0335_RS19260 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) F0335_RS19265 ENOG4105C0B DNA polymerase III (alpha subunit) F0335_RS19270 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F0335_RS19275 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F0335_RS19280 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F0335_RS19285 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) F0335_RS19290 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F0335_RS19295 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) F0335_RS19300 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane F0335_RS19305 ENOG4105DZP Membrane-associated zinc metalloprotease F0335_RS19310 ENOG4105KNE Phosphatidate cytidylyltransferase F0335_RS19315 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F0335_RS19320 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) F0335_RS19325 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) F0335_RS19330 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F0335_RS19335 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) F0335_RS19340 ENOG4105CE9 30S ribosomal protein S2 F0335_RS19345 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F0335_RS19350 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) F0335_RS19360 ENOG4108T8E UPF0325 protein F0335_RS19365 ENOG4105QDK Flavodoxin F0335_RS19370 ENOG4105DR9 pseudouridine synthase F0335_RS19380 ENOG4105DN3 alpha-2-macroglobulin domain protein F0335_RS19385 ENOG4105WP7 tRNA pseudouridine synthase C F0335_RS19390 ENOG4107RGD Major Facilitator superfamily F0335_RS19405 ENOG4105EWT decarboxylase family F0335_RS19410 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease F0335_RS19415 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) F0335_RS19420 ENOG4105M08 Membrane F0335_RS19425 ENOG4105ETT transcriptional Regulator, LysR family F0335_RS19430 ENOG4105M5B (LipO)protein F0335_RS19435 ENOG4105C9B Cysteine desulfurase F0335_RS19440 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) F0335_RS19445 ENOG4105CUZ uba thif-type nad fad binding protein F0335_RS19450 ENOG4105CA3 membrane-bound lytic murein transglycosylase F0335_RS19470 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F0335_RS19475 ENOG4107QZM n-acetylglutamate synthase F0335_RS19480 ENOG4107QYX exodeoxyribonuclease v alpha F0335_RS19485 ENOG4107QKA exodeoxyribonuclease V beta F0335_RS19490 ENOG4107QXK peptidase F0335_RS19495 ENOG4105DSY exodeoxyribonuclease V, gamma F0335_RS19515 ENOG4105IPU prepilin peptidase dependent protein A F0335_RS19520 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) F0335_RS19525 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) F0335_RS19530 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase F0335_RS19535 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F0335_RS19540 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) F0335_RS19550 ENOG4105SUV lipoprotein YgdR F0335_RS19555 ENOG4105CPC Aldo Keto reductase F0335_RS19560 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) F0335_RS19565 ENOG4105CEY Amp-dependent synthetase and ligase F0335_RS19575 ENOG4105GQR Chaperone F0335_RS19580 ENOG4108D1K outer membrane usher protein F0335_RS19600 ENOG41060NJ transcriptional regulator F0335_RS19610 ENOG4105RQF LysR family Transcriptional regulator F0335_RS19615 ENOG4105EJC lysr family transcriptional regulator F0335_RS19645 ENOG4105F3R pts system mannose fructose sorbose family iid F0335_RS19650 ENOG4105ETZ PTS System F0335_RS19655 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB F0335_RS19660 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of F0335_RS19665 ENOG4105E98 transcriptional regulator DeoR family F0335_RS19670 ENOG4105DJ2 Major Facilitator Superfamily F0335_RS19685 ENOG4105IBP Cyclic peptide transporter F0335_RS19690 ENOG4105CC0 LysR family Transcriptional regulator F0335_RS19695 ENOG4105DAA L-lactate F0335_RS19700 ENOG4105DMF Dehydrogenase F0335_RS19720 ENOG4105C94 Transporter F0335_RS19725 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) F0335_RS19730 ENOG4108JJ7 ABC transporter F0335_RS19740 ENOG4108K5P (LipO)protein F0335_RS19745 ENOG4108YK4 Acid-resistance membrane protein F0335_RS19760 ENOG4105UYK outer membrane protein a F0335_RS19775 ENOG4105C9B Cysteine desulfurase F0335_RS19785 ENOG4105C94 Transporter F0335_RS19795 ENOG4105CRK lysyL-tRNA synthetase F0335_RS19805 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) F0335_RS19810 ENOG4105T95 Thiol disulfide interChange protein F0335_RS19815 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F0335_RS19820 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) F0335_RS19825 ENOG4105CT7 inner membrane cred family protein F0335_RS19830 ENOG4105EB3 Histidine kinase F0335_RS19835 ENOG4105E3W Two component transcriptional regulator (Winged helix family F0335_RS19845 ENOG4105Y75 tpr repeat protein F0335_RS19850 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) F0335_RS19860 ENOG4108UT2 hemolysin iii F0335_RS19870 ENOG4108RVA ribokinase F0335_RS19875 ENOG4107TFG D-allose kinase F0335_RS19880 ENOG4105UP7 3-epimerase F0335_RS19890 ENOG4105CNN ABC, transporter F0335_RS19895 ENOG4105C2J ABC transporter F0335_RS19905 ENOG4105E98 transcriptional regulator DeoR family F0335_RS19920 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F0335_RS19950 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor F0335_RS19955 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) F0335_RS19960 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) F0335_RS19965 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family F0335_RS19970 ENOG4105D0A hydroxylase F0335_RS19975 ENOG4107RAQ aminopeptidase F0335_RS19980 ENOG4105E07 UPF0149 protein F0335_RS19985 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) F0335_RS19995 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase F0335_RS20000 ENOG4108JQ1 Dehydrogenase F0335_RS20010 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) F0335_RS20015 ENOG4105MPN Membrane F0335_RS20020 ENOG4108ZUB Lysine exporter protein (Lyse ygga) F0335_RS20025 ENOG4105J4Q Transcriptional regulator F0335_RS20030 ENOG4105C2J ABC transporter F0335_RS20035 ENOG4105CNN ABC, transporter F0335_RS20055 ENOG4108R66 Conserved Protein F0335_RS20065 ENOG4105CMG Carbohydrate kinase F0335_RS20070 ENOG4105H6Q decarboxylase F0335_RS20075 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase F0335_RS20080 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase F0335_RS20085 ENOG4105D3G Pseudouridine synthase F0335_RS20090 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme F0335_RS20100 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) F0335_RS20110 ENOG4105D64 Mechanosensitive ion channel F0335_RS20120 ENOG4105D2N Aldolase F0335_RS20125 ENOG4105BZA Phosphoglycerate kinase F0335_RS20130 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F0335_RS20135 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0335_RS20140 ENOG4107Z33 ABC transporter, permease F0335_RS20155 ENOG4108Z7R Chaperone CsaA F0335_RS20165 ENOG4105CWM branched-chain amino acid transport system II carrier protein F0335_RS20170 ENOG4105CV1 Transketolase (EC 2.2.1.1) F0335_RS20175 ENOG4108K0D peptidase, M48 F0335_RS20190 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) F0335_RS20195 ENOG4105CHR reductase F0335_RS20215 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase F0335_RS20225 ENOG4108FUF Transcriptional regulator, IclR family F0335_RS20230 ENOG4105CHR reductase F0335_RS20250 ENOG4105DJB Major Facilitator Superfamily F0335_RS20260 ENOG4105CYW agmatinase F0335_RS20265 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) F0335_RS20275 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP F0335_RS20285 ENOG4105S6R Iron-hydroxamate transporter permease subunit F0335_RS20290 ENOG4105J76 Periplasmic binding protein F0335_RS20295 ENOG4105E0A ABC, transporter F0335_RS20300 ENOG4105E0K tonB-dependent siderophore receptor F0335_RS20305 ENOG4105BZ4 penicillin-binding protein F0335_RS20310 ENOG4105CQ7 ATP-dependent helicase F0335_RS20315 ENOG4107XID 2'-5' rna ligase F0335_RS20320 ENOG4105PW4 Sugar fermentation stimulation protein homolog F0335_RS20325 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters F0335_RS20330 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) F0335_RS20335 ENOG4105DJ0 Poly(A) Polymerase F0335_RS20340 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase F0335_RS20345 ENOG4105DHQ Histidine kinase F0335_RS20350 ENOG4105XJC Two component transcriptional regulator (Winged helix family F0335_RS20355 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) F0335_RS20360 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) F0335_RS20365 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) F0335_RS20370 ENOG4107BJW polysaccharide deacetylase F0335_RS20375 ENOG4105E3A (ABC) transporter F0335_RS20380 ENOG4105DA5 (ABC) transporter F0335_RS20385 ENOG41077A9 carbonic anhydrase F0335_RS20390 ENOG4108UGV hypoxanthine phosphoribosyltransferase F0335_RS20405 ENOG4105E3B Multicopper oxidase F0335_RS20410 ENOG4108ZRK uncharacterized protein yacC F0335_RS20415 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) F0335_RS20420 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) F0335_RS20425 ENOG4108ZIG UPF0231 protein F0335_RS20430 ENOG4107QIJ Aconitate hydratase 2 F0335_RS20435 ENOG4107QN2 dihydrolipoyl dehydrogenase F0335_RS20440 ENOG4107QSN dihydrolipoamide acetyltransferase F0335_RS20445 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) F0335_RS20450 ENOG41073TP transcriptional regulator F0335_RS20455 ENOG4105C85 amino acid F0335_RS20460 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding F0335_RS20470 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding F0335_RS20480 ENOG4105XRQ Xanthine dehydrogenase accessory factor F0335_RS20485 ENOG4105UEI Transcriptional Regulator AraC Family F0335_RS20490 ENOG4107GFK fumarate F0335_RS20495 ENOG4105GPY SprT protein F0335_RS20500 ENOG4105RWS endonuclease I F0335_RS20505 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) F0335_RS20510 ENOG4105D7Z glutathione synthase F0335_RS20515 ENOG4108UJU UPF0301 protein F0335_RS20520 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) F0335_RS20525 ENOG4105CZX twitching motility protein F0335_RS20530 ENOG4105DFA alanine racemase domain protein F0335_RS20535 ENOG4105II7 pyrroline-5-carboxylate reductase F0335_RS20540 ENOG4108VIA integral membrane protein F0335_RS20545 ENOG4105VZ9 UPF0235 protein F0335_RS20555 ENOG4105CSA Coproporphyrinogen iii oxidase F0335_RS20570 ENOG4105K33 Periplasmic Protein F0335_RS20575 ENOG4105CSV Glutaminase F0335_RS20580 ENOG41090ED Protein with unknown function (DUF469) F0335_RS20585 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) F0335_RS20590 ENOG4105CEN a g-specific adenine glycosylase F0335_RS20595 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) F0335_RS20600 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division F0335_RS20605 ENOG4105CXN decarboxylase F0335_RS20615 ENOG4108WC9 type VI secretion system effector, hcp1 family F0335_RS20620 ENOG4108WC9 type VI secretion system effector, hcp1 family F0335_RS20630 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) F0335_RS20640 ENOG4105NIV Esterase F0335_RS20645 ENOG4105VEV -acetyltransferase F0335_RS20685 ENOG4105GAV receptor F0335_RS20690 ENOG4106KR7 LysR family Transcriptional regulator F0335_RS20695 ENOG4105CH2 amidohydrolase F0335_RS20700 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B F0335_RS20705 ENOG4105CFC Transporter F0335_RS20710 ENOG4105D7K pfkb domain protein F0335_RS20730 ENOG4105WBN Transcriptional regulator (LacI family F0335_RS20735 ENOG4108ZZF transport protein (ExbD) F0335_RS20740 ENOG4105CWK Biopolymer transport protein, ExbB F0335_RS20745 ENOG4105C28 cystathionine F0335_RS20750 ENOG4108K81 inner membrane protein YghB F0335_RS20755 ENOG4105CC0 LysR family Transcriptional regulator F0335_RS20765 ENOG4105CF7 AraC family transcriptional regulator F0335_RS20770 ENOG4108I6A alcohol dehydrogenase F0335_RS20775 ENOG4105CV8 reductase F0335_RS20780 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division F0335_RS20790 ENOG4105C6F GntR Family Transcriptional Regulator F0335_RS20800 ENOG4108TFM Kinase, PfkB family F0335_RS20805 ENOG4105EAA nucleoside F0335_RS20810 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) F0335_RS20815 ENOG4105CN8 Transcriptional regulator F0335_RS20820 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) F0335_RS20825 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase F0335_RS20830 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0335_RS20835 ENOG4105NF4 modulator of drug activity F0335_RS20840 ENOG4105VRH Antibiotic biosynthesis monooxygenase F0335_RS20845 ENOG4105HEI LysR family (Transcriptional regulator F0335_RS20850 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0335_RS20855 ENOG4105IPS esterase F0335_RS20860 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) F0335_RS20865 ENOG4108SX3 cytoplasmic protein F0335_RS20870 ENOG41087AY ADP-Ribose pyrophosphatase F0335_RS20875 ENOG4105DFG type I secretion outer membrane protein F0335_RS20885 ENOG4105VDH Dihydroxyacetone kinase F0335_RS20890 ENOG4108UTZ Dihydroxyacetone kinase F0335_RS20895 ENOG4105CMT Dihydroxyacetone kinase F0335_RS20905 ENOG4105F1G UPF0441 protein F0335_RS20910 ENOG4106032 Glutathionylspermidine synthase F0335_RS20915 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F0335_RS20925 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) F0335_RS20930 ENOG4105W0Z cytoplasmic protein F0335_RS20935 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) F0335_RS20940 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) F0335_RS20945 ENOG4105I7R Adenylate cyclase F0335_RS20950 ENOG4106MWK domain protein F0335_RS20955 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate F0335_RS20960 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F0335_RS20965 ENOG4107ZVW dihydroneopterin aldolase F0335_RS20970 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) F0335_RS20975 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F0335_RS20985 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F0335_RS20990 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0335_RS21030 ENOG4108SHQ Glutathione S-transferase F0335_RS21040 ENOG4105C26 Dehydrogenase F0335_RS21045 ENOG4108JPW Aminotransferase F0335_RS21055 ENOG4105C5H ABC transporter F0335_RS21060 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F0335_RS21065 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) F0335_RS21070 ENOG4108VKG metal-dependent hydrolase F0335_RS21075 ENOG4105EE0 oxidoreductase F0335_RS21085 ENOG4105DU1 integral membrane protein, terc F0335_RS21090 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) F0335_RS21095 ENOG4105CTX dehydratase F0335_RS21100 ENOG4105D2H Uronic isomerase F0335_RS21110 ENOG4105DPW Major facilitator superfamily MFS_1 F0335_RS21125 ENOG4106W5V Membrane F0335_RS21130 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) F0335_RS21140 ENOG4105NE1 Conserved Protein F0335_RS21145 ENOG41090KG Inner membrane protein YqjE F0335_RS21150 ENOG4105YJD F0335_RS21155 ENOG4108VBZ doxx family F0335_RS21160 ENOG4105CHF Glutathione S-transferase F0335_RS21165 ENOG4105CWB LysR family transcriptional Regulator F0335_RS21170 ENOG4108CNN domain protein F0335_RS21180 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) F0335_RS21185 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) F0335_RS21190 ENOG41082RQ UPF0102 protein F0335_RS21195 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) F0335_RS21200 ENOG4105W4M Transport-associated protein F0335_RS21210 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain F0335_RS21215 ENOG4105BZU Histidine kinase F0335_RS21220 ENOG4105N5T Radical SAM Protein F0335_RS21225 ENOG4105CBC glutamate synthase F0335_RS21230 ENOG4105BZ8 glutamate synthase F0335_RS21240 ENOG4105KB2 stringent starvation protein b F0335_RS21245 ENOG4107MKT Stringent starvation protein a F0335_RS21250 ENOG4108UJD 30S ribosomal protein S9 F0335_RS21255 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) F0335_RS21260 ENOG4105D6Z AFG1 family ATPase F0335_RS21265 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III F0335_RS21270 ENOG4105C0H protease F0335_RS21275 ENOG4105C0H protease F0335_RS21280 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F0335_RS21285 ENOG4105VFK BolA family F0335_RS21290 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane F0335_RS21295 ENOG4105E3I toluene tolerance F0335_RS21300 ENOG4107PE3 Mammalian cell entry related domain protein F0335_RS21305 ENOG4105CY3 ABC transporter, permease F0335_RS21310 ENOG4105DHJ ABC, transporter F0335_RS21315 ENOG4105FEU K -dependent Na -Ca exchanger F0335_RS21320 ENOG4105C2X Arabinose 5-phosphate isomerase F0335_RS21325 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase F0335_RS21330 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) F0335_RS21335 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA F0335_RS21340 ENOG4108IUZ ABC transporter F0335_RS21345 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0335_RS21350 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA F0335_RS21355 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN F0335_RS21360 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) F0335_RS21365 ENOG41080Z8 PHOSPHOCARRIER protein F0335_RS21370 ENOG4105EMD TRANSCRIPTIONal F0335_RS21375 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) F0335_RS21390 ENOG41069H0 dihydroorotase EC 3.5.2.3 F0335_RS21420 ENOG4105NXH GreA GreB family elongation factor F0335_RS21430 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) F0335_RS21440 ENOG4105R1U AraC Family Transcriptional Regulator F0335_RS21445 ENOG4108XVM Cytochrome b(562) F0335_RS21450 ENOG4105CMS peptidase U62, modulator of DNA gyrase F0335_RS21455 ENOG4105N42 UPF0307 protein F0335_RS21460 ENOG4105UNR (Barnase) inhibitor F0335_RS21470 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) F0335_RS21475 ENOG4105Y49 secretion protein, HlyD family F0335_RS21485 ENOG4105CR8 Transcriptional regulator F0335_RS21510 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F0335_RS21525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F0335_RS21555 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) F0335_RS21600 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) F0335_RS21605 ENOG4105D1U peptidase U62 modulator of DNA gyrase F0335_RS21615 ENOG4105QD6 exported protein F0335_RS21620 ENOG4105C03 ribonuclease F0335_RS21625 ENOG4108Z03 MAF-like protein F0335_RS21630 ENOG4105VQ7 Rod shape-determining protein MreD F0335_RS21635 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) F0335_RS21645 ENOG41062P1 Diguanylate cyclase phosphodiesterase F0335_RS21650 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family F0335_RS21655 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) F0335_RS21660 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) F0335_RS21665 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) F0335_RS21670 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein F0335_RS21675 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F0335_RS21685 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F0335_RS21695 ENOG4105E5W Transporter F0335_RS21705 ENOG4105RG0 Membrane F0335_RS21710 ENOG4108IA2 Sodium pantothenate symporter F0335_RS21715 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) F0335_RS21740 ENOG4105D1S lipid A biosynthesis F0335_RS21745 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) F0335_RS21780 ENOG4105CMU LysR family (Transcriptional regulator F0335_RS21785 ENOG4105EEQ Na H antiporter F0335_RS21790 ENOG4105C7N Xanthine uracil vitamin C permease F0335_RS21800 ENOG4108RXX maleylacetoacetate isomerase F0335_RS21815 ENOG4105F6U Short-chain dehydrogenase reductase Sdr F0335_RS21825 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F0335_RS21830 ENOG4105DQ4 alcohol dehydrogenase F0335_RS21835 ENOG4108UW5 maltose o-acetyltransferase F0335_RS21840 ENOG4105MSB protein, conserved in bacteria F0335_RS21845 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme F0335_RS21850 ENOG4105CGF Aromatic amino acid aminotransferase F0335_RS21855 ENOG4105F7P transcriptional regulator AsnC family F0335_RS21860 ENOG4105F87 Dehydratase F0335_RS21870 ENOG4105CDU Replicative dna helicase F0335_RS21875 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F0335_RS21880 ENOG4105P4Z Phage shock protein G F0335_RS21885 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F0335_RS21895 ENOG4105MYN Zinc uptake regulation protein F0335_RS21900 ENOG4105VDW Csbd family F0335_RS21905 ENOG4107R73 Mate efflux family protein F0335_RS21910 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) F0335_RS21915 ENOG41080IJ Diacylglycerol kinase F0335_RS21920 ENOG4105E55 glycerol-3-phosphate acyltransferase F0335_RS21925 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) F0335_RS21930 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) F0335_RS21940 ENOG4105ETE Transcriptional regulator (LacI family F0335_RS21950 ENOG4107W52 maltose operon periplasmic protein F0335_RS21955 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) F0335_RS21970 ENOG4107FKK extracellular solute-binding protein family 1 F0335_RS21975 ENOG4105D56 permease protein F0335_RS21980 ENOG4105EG2 ABC transporter, permease F0335_RS21985 ENOG4108VY7 phosphate-starvation-inducible protein PsiE F0335_RS21990 ENOG4108MRJ F0335_RS21995 ENOG4107QP8 phosphohexose isomerase F0335_RS22005 ENOG4105CFH Aspartokinase F0335_RS22010 ENOG4105C09 Bile acid F0335_RS22025 ENOG4105EAM Na Pi-cotransporter F0335_RS22030 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0335_RS22055 ENOG4106S9K Transcriptional regulator F0335_RS22060 ENOG4105C3R Methionine synthase F0335_RS22065 ENOG41069M3 Transcriptional regulator F0335_RS22070 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family F0335_RS22075 ENOG4105C6Z Gluconate F0335_RS22080 ENOG4105C01 Dihydroxy-acid dehydratase F0335_RS22085 ENOG4108UHU Aldolase F0335_RS22090 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) F0335_RS22095 ENOG4108I9X Isocitrate lyase F0335_RS22100 ENOG4107QP3 malate synthase g F0335_RS22105 ENOG4105CVG Homoserine O-transsuccinylase F0335_RS22145 ENOG4108Z0R Transferase F0335_RS22150 ENOG4105E2X shikimate dehydrogenase F0335_RS22155 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F0335_RS22160 ENOG4108WI1 Dna topoisomerase F0335_RS22165 ENOG4108RPN Protein smg homolog F0335_RS22170 ENOG4105C79 DNA protecting protein DprA F0335_RS22175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F0335_RS22180 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) F0335_RS22185 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B F0335_RS22190 ENOG4105C1A potassium transporter peripheral membrane F0335_RS22195 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) F0335_RS22200 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system F0335_RS22205 ENOG4105W1Y Transcriptional regulator F0335_RS22210 ENOG4105VTS DnaJ-like, subfamily C F0335_RS22215 ENOG4108ZT0 50S ribosomal protein l17 F0335_RS22220 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F0335_RS22225 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) F0335_RS22230 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) F0335_RS22235 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits F0335_RS22245 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F0335_RS22255 ENOG4105VPB 50S ribosomal protein L30 F0335_RS22260 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) F0335_RS22265 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) F0335_RS22270 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) F0335_RS22275 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) F0335_RS22290 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) F0335_RS22300 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal F0335_RS22305 ENOG41083MP 50s ribosomal protein l29 F0335_RS22310 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) F0335_RS22315 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) F0335_RS22335 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) F0335_RS22340 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) F0335_RS22345 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) F0335_RS22365 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) F0335_RS22370 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) F0335_RS22375 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) F0335_RS22380 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) F0335_RS22385 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) F0335_RS22390 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) F0335_RS22395 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) F0335_RS22400 ENOG4105WWK YheO domain protein F0335_RS22405 ENOG4108V1T peptidylprolyl cis-trans isomerase F0335_RS22415 ENOG4105C87 Aminotransferase class I and II F0335_RS22420 ENOG4105DFD Na H antiporter F0335_RS22425 ENOG41060NJ transcriptional regulator F0335_RS22430 ENOG4108YZY peptidylprolyl cis-trans isomerase F0335_RS22435 ENOG4105VKU nucleicacid-binding protein F0335_RS22445 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein F0335_RS22450 ENOG4105C5H ABC transporter F0335_RS22455 ENOG4105E2B Taurine dioxygenase F0335_RS22460 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F0335_RS22470 ENOG4106FTQ Taurine ABC transporter, periplasmic F0335_RS22475 ENOG4105JAB phenazine biosynthesis protein, phzf family F0335_RS22485 ENOG4105DNZ Alpha Beta Hydrolase F0335_RS22490 ENOG4105YP7 UPF0270 protein F0335_RS22495 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) F0335_RS22500 ENOG4108UKZ OsmC family F0335_RS22510 ENOG410613R integral membrane protein, YccS YhfK family F0335_RS22515 ENOG4105C8Y Acetylornithine aminotransferase F0335_RS22525 ENOG4105D7A ATP-binding protein F0335_RS22530 ENOG4108NEV two component transcriptional regulator, LytTR family F0335_RS22535 ENOG4108HRK Histidine kinase F0335_RS22540 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) F0335_RS22545 ENOG4105VCP PTS System F0335_RS22550 ENOG4105F8D glycoside hydrolase family 4 F0335_RS22555 ENOG4105DDV Transcriptional regulator (LacI family F0335_RS22560 ENOG4106DTQ Protein TsgA homolog F0335_RS22565 ENOG4105DZC cytosine deaminase F0335_RS22570 ENOG4107QZF nitrite reductase NADPH large subunit F0335_RS22575 ENOG4105WZK nitrite reductase NADPH small subunit F0335_RS22580 ENOG4107V9H nitrite transporter F0335_RS22585 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F0335_RS22590 ENOG4105C31 Tryptophanyl-tRNA synthetase F0335_RS22595 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F0335_RS22615 ENOG4105D49 3-dehydroquinate synthase F0335_RS22620 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) F0335_RS22625 ENOG4105E4G Type IV pilus F0335_RS22650 ENOG4108JQC penicillin-binding protein 1A F0335_RS22655 ENOG4107RK2 ADP-ribose diphosphatase NudE F0335_RS22660 ENOG4105DQY intracellular growth attenuator F0335_RS22665 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 F0335_RS22670 ENOG4105VEJ Heat shock protein F0335_RS22675 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) F0335_RS22705 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) F0335_RS22710 ENOG4105DVC DnaJ domain protein F0335_RS22715 ENOG4108RRZ Transcription elongation factor GreB F0335_RS22725 ENOG4105XFK Ferrous iron transport protein A F0335_RS22735 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) F0335_RS22750 ENOG4105MJ2 Competence protein F0335_RS22755 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) F0335_RS22765 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) F0335_RS22770 ENOG41061ZR Transcriptional regulator F0335_RS22775 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) F0335_RS22780 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) F0335_RS22785 ENOG4105E98 transcriptional regulator DeoR family F0335_RS22790 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F0335_RS22795 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) F0335_RS22800 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) F0335_RS22805 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) F0335_RS22810 ENOG4108ESZ Glycogen debranching enzyme F0335_RS22815 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) F0335_RS22820 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F0335_RS22825 ENOG41076UM multiple antibiotic resistance (MarC)-related protein F0335_RS22830 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family F0335_RS22835 ENOG4105C6Z Gluconate F0335_RS22840 ENOG4105DIQ Transcriptional regulator F0335_RS22845 ENOG4105C2I pirin domain protein F0335_RS22850 ENOG4105WCN acetyltransferase F0335_RS22855 ENOG4105KXX peptidase s58 dmpa F0335_RS22860 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) F0335_RS22865 ENOG4105F0H myo-inositol catabolism protein F0335_RS22870 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) F0335_RS22875 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) F0335_RS22880 ENOG4105D7K pfkb domain protein F0335_RS22900 ENOG4105DH8 myo-inositol catabolism F0335_RS22905 ENOG4105C26 Dehydrogenase F0335_RS22910 ENOG4107QNK )-transporter F0335_RS22925 ENOG41083J0 (ABC) transporter F0335_RS22950 ENOG4106PG1 outer membrane usher protein F0335_RS22955 ENOG4106P2F Pfam:Pili_assembly_C F0335_RS22975 ENOG4108N8T regulatoR F0335_RS22985 ENOG4105T38 integral membrane protein F0335_RS23015 ENOG4105DU0 nucleoside hydrolase F0335_RS23025 ENOG4105CBX hi0933 family F0335_RS23030 ENOG4105CJ3 phosphate transporter F0335_RS23050 ENOG4105CKD glutathione-regulated potassium-efflux system protein F0335_RS23060 ENOG4105CBN LysR family transcriptional regulator F0335_RS23080 ENOG4105C2J ABC transporter F0335_RS23085 ENOG4105CNN ABC, transporter F0335_RS23090 ENOG4105CNN ABC, transporter F0335_RS23100 ENOG4105C2X Arabinose 5-phosphate isomerase F0335_RS23105 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) F0335_RS23110 ENOG4105DGW oligopeptidase A F0335_RS23135 ENOG4105D6S protein involved in catabolism of external DNA F0335_RS23140 ENOG4105DC8 reductase F0335_RS23150 ENOG4105JAB phenazine biosynthesis protein, phzf family F0335_RS23160 ENOG4107SQD Transcriptional regulator, GntR family F0335_RS23170 ENOG4105BZU Histidine kinase F0335_RS23195 ENOG4105EQN UPF0261 protein F0335_RS23200 ENOG4108SPG Periplasmic Protein F0335_RS23205 ENOG4105BZU Histidine kinase F0335_RS23210 ENOG4105E39 Enoyl-CoA hydratase F0335_RS23215 ENOG4107H3J ribonuclease F0335_RS23220 ENOG4105CSH Transporter F0335_RS23225 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) F0335_RS23230 ENOG41066T0 asmA family F0335_RS23235 ENOG4105CMB EAL domain-containing protein F0335_RS23240 ENOG4107SS6 2-dehydro-3-deoxygluconokinase F0335_RS23245 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F0335_RS23250 ENOG4105EMY transcriptional regulator F0335_RS23275 ENOG4105C01 Dihydroxy-acid dehydratase F0335_RS23280 ENOG4105CM2 brancheD-chain amino acid aminotransferase F0335_RS23285 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit F0335_RS23305 ENOG4105C0P Mg chelatase subunit ChlI F0335_RS23310 ENOG4108WFC UPF0438 protein yifE F0335_RS23315 ENOG4105CVI Transcriptional regulator F0335_RS23350 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) F0335_RS23355 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F0335_RS23360 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) F0335_RS23365 ENOG4108Y73 Membrane F0335_RS23375 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) F0335_RS23380 ENOG4105C5Q Transcriptional regulator F0335_RS23385 ENOG4105EHV domain protein F0335_RS23390 ENOG4107QN2 dihydrolipoyl dehydrogenase F0335_RS23400 ENOG4105CH7 arginosuccinase F0335_RS23405 ENOG4105CDH Citrulline--aspartate ligase F0335_RS23410 ENOG4105CAS nag kinase F0335_RS23425 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) F0335_RS23430 ENOG4105SYT Methylenetetrahydrofolate reductase F0335_RS23435 ENOG4105CFH Aspartokinase F0335_RS23440 ENOG4105C28 cystathionine F0335_RS23445 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) F0335_RS23450 ENOG4105VFB Binds the 23S rRNA (By similarity) F0335_RS23455 ENOG4105C25 Primosomal protein n' F0335_RS23465 ENOG41063M6 Cell Division Protein F0335_RS23470 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) F0335_RS23475 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) F0335_RS23480 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F0335_RS23485 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) F0335_RS23490 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) F0335_RS23495 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F0335_RS23505 ENOG4105CBT Fructose-1,6-bisphosphatase F0335_RS23510 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein F0335_RS23515 ENOG4105E5M Multidrug resistance protein D F0335_RS23525 ENOG4105DP0 ferredoxin-NADP reductase F0335_RS23530 ENOG4108VTS Membrane F0335_RS23535 ENOG4105EBK exported protein F0335_RS23540 ENOG4105CP7 Triose-phosphate isomerase F0335_RS23545 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein F0335_RS23550 ENOG4105CTQ phosphohexokinase F0335_RS23555 ENOG41076HS cation diffusion facilitator family transporter F0335_RS23560 ENOG4105FMW periplasmic F0335_RS23565 ENOG4105E3W Two component transcriptional regulator (Winged helix family F0335_RS23570 ENOG4105E0F Histidine kinase F0335_RS23575 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) F0335_RS23585 ENOG4108KKZ (LipO)protein F0335_RS23590 ENOG4105D7W serine acetyltransferase F0335_RS23605 ENOG4105VW4 glutaredoxin 3 F0335_RS23610 ENOG4107YZP Rhodanese domain protein F0335_RS23615 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F0335_RS23620 ENOG41063SB peptidase F0335_RS23625 ENOG4105PXI polysaccharide deacetylase F0335_RS23630 ENOG4105CPQ Dehydrogenase F0335_RS23635 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F0335_RS23640 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) F0335_RS23645 ENOG4105XA0 heptosyltransferase ii F0335_RS23650 ENOG4105D16 lipopolysaccharide heptosyltransferase i F0335_RS23655 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) F0335_RS23660 ENOG41068PG O-Antigen polymerase F0335_RS23680 ENOG4105DKP glycosyl transferase, family 9 F0335_RS23685 ENOG4107RJ7 Glycosyl transferase (Group 1 F0335_RS23690 ENOG4105CPK Glycosyl transferase (Group 1 F0335_RS23700 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase F0335_RS23720 ENOG4105W0E 50S ribosomal protein L33 F0335_RS23725 ENOG4105KDC 50s ribosomal protein l28 F0335_RS23730 ENOG4105W5Q DNA repair protein (RadC F0335_RS23735 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase F0335_RS23740 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) F0335_RS23745 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) F0335_RS23750 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) F0335_RS23755 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) F0335_RS23760 ENOG4105DSJ YicC domain protein F0335_RS23845 ENOG4105D9N nucleoside F0335_RS23855 ENOG4105EN6 Membrane F0335_RS23860 ENOG410642W LysR family Transcriptional regulator F0335_RS23870 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) F0335_RS23875 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) F0335_RS23880 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F0335_RS23885 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase F0335_RS23890 ENOG4105CB5 ATP-dependent DNA helicase recG F0335_RS23895 ENOG4105D6U Sodium Glutamate Symporter F0335_RS23900 ENOG4105C2W permease F0335_RS23905 ENOG4105JV1 AsmA family F0335_RS23910 ENOG4105SUU thioesterase domain F0335_RS23915 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) F0335_RS23920 ENOG4107S2Z UPF0761 membrane protein F0335_RS23925 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 F0335_RS23930 ENOG4105CI3 gtp-binding protein typa F0335_RS23935 ENOG4105C5F glutamine synthetase F0335_RS23940 ENOG4105CUX Signal transduction histidine kinase F0335_RS23945 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0335_RS23950 ENOG4106FIY F0335_RS23955 ENOG4105D4P Coproporphyrinogen iii oxidase F0335_RS23960 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) F0335_RS23965 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) F0335_RS23970 ENOG4105C2M dna polymerase I F0335_RS23975 ENOG4106HNH Acyl-transferase F0335_RS23980 ENOG4108Z33 Thiol disulfide Interchange Protein F0335_RS23985 ENOG4105E27 serine threonine protein kinase F0335_RS23990 ENOG4105PC1 Conserved Protein F0335_RS23995 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) F0335_RS24000 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b F0335_RS24025 ENOG4107EJG GntR family transcriptional regulator F0335_RS24030 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0335_RS24035 ENOG4105ETE Transcriptional regulator (LacI family F0335_RS24040 ENOG4108RVA ribokinase F0335_RS24045 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F0335_RS24050 ENOG4105CNN ABC, transporter F0335_RS24055 ENOG4105C2J ABC transporter F0335_RS24060 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) F0335_RS24070 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) F0335_RS24075 ENOG4105EV2 VWA domain protein interacting with AAA ATPase F0335_RS24080 ENOG4105CU9 asparagine synthetase A F0335_RS24085 ENOG4108VVK transcriptional Regulator, AsnC F0335_RS24090 ENOG4105QTB Flavodoxin F0335_RS24095 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) F0335_RS24100 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) F0335_RS24105 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation F0335_RS24110 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) F0335_RS24115 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) F0335_RS24120 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) F0335_RS24125 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) F0335_RS24130 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) F0335_RS24135 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) F0335_RS24140 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) F0335_RS24145 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) F0335_RS24150 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) F0335_RS24160 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) F0335_RS24165 ENOG4105C8U phosphate abc transporter F0335_RS24170 ENOG4105E2Z phosphate ABC transporter (Permease F0335_RS24185 ENOG4106PMH Extracellular solute-binding protein family 3 F0335_RS24190 ENOG4105EAD ABC transporter F0335_RS24195 ENOG4105E5Q amino acid AbC transporter F0335_RS24200 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 F0335_RS24210 ENOG4105C7N Xanthine uracil vitamin C permease F0335_RS24220 ENOG4108YYH Nadph-dependent fmn reductase F0335_RS24225 ENOG4107YAK holo-(acyl carrier protein) synthase 2 F0335_RS24235 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) F0335_RS24240 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F0335_RS24245 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) F0335_RS24250 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) F0335_RS24255 ENOG4105VG0 50S ribosomal protein l34