locus-tag	class	description
F0335_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0335_RS00010	COG0592	DNA-directed DNA polymerase activity
F0335_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0335_RS00020	COG0187	DNA topoisomerase II activity
F0335_RS00025	COG0561	phosphatase activity
F0335_RS00030	COG2423	ornithine cyclodeaminase activity
F0335_RS00045	COG0823	Involved in the tonB-independent uptake of proteins
F0335_RS00050	COG5645	(Lipo)protein
F0335_RS00055	COG0071	Belongs to the small heat shock protein (HSP20) family
F0335_RS00060	COG0071	Belongs to the small heat shock protein (HSP20) family
F0335_RS00065	COG2985	domain, Protein
F0335_RS00075	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F0335_RS00080	COG3977	Valine--pyruvate aminotransferase
F0335_RS00085	COG0366	Alpha amylase catalytic
F0335_RS00095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0335_RS00100	COG2814	Major facilitator Superfamily
F0335_RS00105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0335_RS00115	COG1609	Transcriptional regulator
F0335_RS00120	COG2885	chlorophyll binding
F0335_RS00130	COG2818	Glycosylase
F0335_RS00140	COG2771	luxR family
F0335_RS00150	COG0752	glycyl-tRNA synthetase alpha subunit
F0335_RS00155	COG0751	glycine-tRNA ligase activity
F0335_RS00170	COG0246	Mannitol dehydrogenase
F0335_RS00175	COG3722	fumarate hydratase activity
F0335_RS00185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0335_RS00200	COG2258	MOSC domain
F0335_RS00205	COG0840	transmembrane signaling receptor activity
F0335_RS00210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F0335_RS00220	COG0437	4 iron, 4 sulfur cluster binding
F0335_RS00225	COG2864	formate dehydrogenase
F0335_RS00230	COG3058	Necessary for formate dehydrogenase activity
F0335_RS00240	COG0625	glutathione transferase activity
F0335_RS00245	COG1921	L-seryl-tRNASec selenium transferase activity
F0335_RS00250	COG3276	selenocysteine insertion sequence binding
F0335_RS00270	COG3274	enterobacterial common antigen metabolic process
F0335_RS00280	COG1335	isochorismatase
F0335_RS00285	COG0402	S-adenosylhomocysteine deaminase activity
F0335_RS00290	COG0583	DNA-binding transcription factor activity
F0335_RS00295	COG2807	transmembrane transport
F0335_RS00380	COG2814	Major facilitator Superfamily
F0335_RS00420	COG1846	Transcriptional regulator
F0335_RS00425	COG1764	response to oxidative stress
F0335_RS00430	COG2194	sulfuric ester hydrolase activity
F0335_RS00435	COG2197	response regulator
F0335_RS00445	COG2271	Major facilitator Superfamily
F0335_RS00470	COG0747	negative chemotaxis
F0335_RS00475	COG0601	transmembrane transport
F0335_RS00480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0335_RS00485	COG0444	Belongs to the ABC transporter superfamily
F0335_RS00490	COG4608	Belongs to the ABC transporter superfamily
F0335_RS00495	COG2194	sulfuric ester hydrolase activity
F0335_RS00520	COG1215	transferase activity, transferring glycosyl groups
F0335_RS00525	COG1215	transferase activity, transferring glycosyl groups
F0335_RS00530	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
F0335_RS00535	COG3118	belongs to the thioredoxin family
F0335_RS00535	COG0457	Tetratricopeptide repeat
F0335_RS00540	COG2199	diguanylate cyclase activity
F0335_RS00540	COG2200	EAL domain
F0335_RS00545	COG1301	dicarboxylic acid transport
F0335_RS00550	COG0612	Peptidase, M16
F0335_RS00555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0335_RS00565	COG0248	Ppx GppA phosphatase
F0335_RS00575	COG3118	belongs to the thioredoxin family
F0335_RS00580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F0335_RS00585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0335_RS00595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0335_RS00600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0335_RS00605	COG1088	dTDP-glucose 4,6-dehydratase activity
F0335_RS00610	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F0335_RS00615	COG0456	acetyltransferase
F0335_RS00620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0335_RS00625	COG2244	polysaccharide biosynthetic process
F0335_RS00630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0335_RS00640	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F0335_RS00675	COG3071	HemY protein
F0335_RS00680	COG2959	enzyme of heme biosynthesis
F0335_RS00685	COG1587	Uroporphyrinogen-III synthase
F0335_RS00690	COG0181	hydroxymethylbilane synthase activity
F0335_RS00695	COG3072	Adenylate cyclase
F0335_RS00700	COG1965	Belongs to the frataxin family
F0335_RS00705	COG5567	small periplasmic lipoprotein
F0335_RS00710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0335_RS00715	COG3159	Protein conserved in bacteria
F0335_RS00725	COG1011	Hydrolase
F0335_RS00730	COG0210	DNA helicase
F0335_RS00750	COG2050	protein possibly involved in aromatic compounds catabolism
F0335_RS00760	COG0514	ATP-dependent DNA helicase (RecQ)
F0335_RS00765	COG1280	lysine exporter protein (LysE YggA)
F0335_RS00770	COG1280	lysine exporter protein (LysE YggA)
F0335_RS00775	COG2267	carboxylic ester hydrolase activity
F0335_RS00780	COG0561	phosphatase activity
F0335_RS00785	COG0584	glycerophosphoryl diester phosphodiesterase
F0335_RS00790	COG2271	Major facilitator Superfamily
F0335_RS00795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0335_RS00805	COG0247	lactate metabolic process
F0335_RS00820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F0335_RS00825	COG0425	Belongs to the sulfur carrier protein TusA family
F0335_RS00830	COG2217	Heavy metal translocating P-type atpase
F0335_RS00845	COG3714	YhhN family
F0335_RS00855	COG3776	membrane
F0335_RS00860	COG0742	ribosomal rna small subunit methyltransferase
F0335_RS00865	COG0552	protein localization to endoplasmic reticulum
F0335_RS00865	COG0552	protein localization to endoplasmic reticulum
F0335_RS00870	COG2884	Cell division ATP-binding protein ftsE
F0335_RS00875	COG2177	Part of the ABC transporter FtsEX involved in
F0335_RS00895	COG0456	acetyltransferase
F0335_RS00905	COG0559	Belongs to the binding-protein-dependent transport system permease family
F0335_RS00910	COG4177	L-phenylalanine transmembrane transporter activity
F0335_RS00920	COG0410	ABC transporter
F0335_RS00925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0335_RS00930	COG1653	transport
F0335_RS00935	COG1175	transmembrane transport
F0335_RS00945	COG3842	ATPase activity
F0335_RS00950	COG0584	glycerophosphoryl diester phosphodiesterase
F0335_RS00965	COG0697	spore germination
F0335_RS00975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0335_RS00980	COG0412	Dienelactone hydrolase
F0335_RS00995	COG0586	Pfam SNARE associated Golgi protein
F0335_RS01000	COG1322	Protein conserved in bacteria
F0335_RS01005	COG2226	methyltransferase
F0335_RS01010	COG3165	ubiquinone biosynthetic process from chorismate
F0335_RS01015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F0335_RS01020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0335_RS01030	COG0805	protein transport
F0335_RS01035	COG0084	hydrolase, TatD family'
F0335_RS01065	COG0183	Belongs to the thiolase family
F0335_RS01070	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0335_RS01070	COG1024	Enoyl-CoA hydratase
F0335_RS01080	COG0006	proline dipeptidase activity
F0335_RS01085	COG1739	Uncharacterized protein family UPF0029
F0335_RS01090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0335_RS01120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F0335_RS01125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F0335_RS01125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F0335_RS01130	COG1072	(Pantothenic acid kinase))
F0335_RS01165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0335_RS01175	COG0250	Participates in transcription elongation, termination and antitermination
F0335_RS01190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0335_RS01200	COG0085	RNA polymerase activity
F0335_RS01205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0335_RS01235	COG2022	thiamine diphosphate biosynthetic process
F0335_RS01240	COG2104	thiamine diphosphate biosynthetic process
F0335_RS01245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0335_RS01250	COG0352	thiamine-phosphate diphosphorylase activity
F0335_RS01255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0335_RS01260	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
F0335_RS01265	COG2816	NAD+ diphosphatase activity
F0335_RS01270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F0335_RS01275	COG1515	deoxyribonuclease V activity
F0335_RS01295	COG0151	Belongs to the GarS family
F0335_RS01300	COG0138	bifunctional purine biosynthesis protein purh
F0335_RS01330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0335_RS01335	COG3162	membrane
F0335_RS01340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0335_RS01345	COG1301	dicarboxylic acid transport
F0335_RS01350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0335_RS01350	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F0335_RS01360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0335_RS01365	COG1629	transport
F0335_RS01365	COG4774	siderophore transport
F0335_RS01370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0335_RS01375	COG3391	amine dehydrogenase activity
F0335_RS01380	COG4771	TonB-dependent receptor
F0335_RS01385	COG2382	esterase
F0335_RS01395	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F0335_RS01395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0335_RS01405	COG1169	isochorismate synthase
F0335_RS01410	COG1021	2,3-dihydroxybenzoate-AMP ligase
F0335_RS01415	COG1535	isochorismatase
F0335_RS01415	COG3433	isochorismatase activity
F0335_RS01425	COG3647	Membrane
F0335_RS01455	COG3188	usher protein
F0335_RS01465	COG3121	Chaperone
F0335_RS01475	COG3539	Fimbrial protein
F0335_RS01520	COG1309	transcriptional regulator
F0335_RS01525	COG4232	protein-disulfide reductase activity
F0335_RS01550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0335_RS01565	COG1509	lysine 2,3-aminomutase activity
F0335_RS01570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0335_RS01575	COG5510	response to toxic substance
F0335_RS01580	COG5510	response to toxic substance
F0335_RS01590	COG3040	lipid binding
F0335_RS01595	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F0335_RS01600	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F0335_RS01605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0335_RS01610	COG1053	succinate dehydrogenase
F0335_RS01615	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F0335_RS01625	COG0688	phosphatidylethanolamine metabolic process
F0335_RS01630	COG1162	GTPase activity
F0335_RS01635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F0335_RS01655	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0335_RS01660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0335_RS01660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F0335_RS01665	COG0802	atpase or kinase
F0335_RS01675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F0335_RS01680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0335_RS01690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0335_RS01695	COG0330	HflC and HflK could
F0335_RS01700	COG0330	HflC and HflK could
F0335_RS01705	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
F0335_RS01710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0335_RS01715	COG1959	2 iron, 2 sulfur cluster binding
F0335_RS01720	COG0557	exoribonuclease II activity
F0335_RS01725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0335_RS01730	COG1960	acyl-CoA dehydrogenase activity
F0335_RS01735	COG3766	membrane
F0335_RS01745	COG3650	response to hydrogen peroxide
F0335_RS01750	COG1073	alpha beta
F0335_RS01765	COG0360	Binds together with S18 to 16S ribosomal RNA
F0335_RS01775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0335_RS01780	COG0359	binds to the 23S rRNA
F0335_RS01790	COG3061	Opacity-associated protein A
F0335_RS01795	COG0545	Peptidyl-prolyl cis-trans isomerase
F0335_RS01805	COG0737	Belongs to the 5'-nucleotidase family
F0335_RS01815	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F0335_RS01825	COG1253	flavin adenine dinucleotide binding
F0335_RS01830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0335_RS01835	COG0729	surface antigen
F0335_RS01840	COG2911	Protein conserved in bacteria
F0335_RS01845	COG2105	PFAM AIG2 family protein
F0335_RS01850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0335_RS01860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F0335_RS01880	COG1438	arginine binding
F0335_RS01885	COG0039	L-malate dehydrogenase activity
F0335_RS01890	COG3423	Transcriptional regulator
F0335_RS01900	COG0142	geranyltranstransferase activity
F0335_RS01905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0335_RS01910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0335_RS01920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0335_RS01925	COG0642	Histidine kinase
F0335_RS01930	COG0745	RESPONSE REGULATOR receiver
F0335_RS01935	COG2027	D-alanyl-D-alanine carboxypeptidase
F0335_RS01945	COG1534	Rna-binding protein
F0335_RS01950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F0335_RS01960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0335_RS01965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0335_RS01970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0335_RS01985	COG0779	Required for maturation of 30S ribosomal subunits
F0335_RS01990	COG0195	Participates in both transcription termination and antitermination
F0335_RS01995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0335_RS02000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0335_RS02005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F0335_RS02010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0335_RS02015	COG1185	polyribonucleotide nucleotidyltransferase activity
F0335_RS02030	COG0513	Belongs to the DEAD box helicase family
F0335_RS02035	COG2391	methyltransferase activity
F0335_RS02040	COG0425	Belongs to the sulfur carrier protein TusA family
F0335_RS02045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0335_RS02065	COG0826	peptidase U32
F0335_RS02070	COG0826	peptidase U32
F0335_RS02075	COG3154	lipid carrier protein
F0335_RS02080	COG3153	acetyltransferase
F0335_RS02085	COG2827	Endonuclease containing a URI domain
F0335_RS02090	COG0531	amino acid
F0335_RS02095	COG1982	Orn Lys Arg decarboxylase major
F0335_RS02105	COG3787	Belongs to the UPF0306 family
F0335_RS02115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F0335_RS02120	COG0702	epimerase
F0335_RS02125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F0335_RS02135	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F0335_RS02140	COG3454	Phosphonate metabolism
F0335_RS02145	COG4778	phosphonate C-P lyase system protein PhnL
F0335_RS02150	COG4107	phosphonate C-P lyase system protein PhnK
F0335_RS02155	COG3627	carbon phosphorus lyase activity
F0335_RS02160	COG3626	phosphonate metabolism
F0335_RS02165	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
F0335_RS02170	COG3624	Phosphonate C-P lyase system protein PhnG
F0335_RS02175	COG2188	Transcriptional regulator
F0335_RS02180	COG0701	Predicted permease
F0335_RS02195	COG0602	queuosine metabolic process
F0335_RS02205	COG0583	DNA-binding transcription factor activity
F0335_RS02210	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0335_RS02215	COG0366	Alpha amylase catalytic
F0335_RS02220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS02220	COG1263	PTS System
F0335_RS02230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0335_RS02250	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
F0335_RS02255	COG0540	Belongs to the ATCase OTCase family
F0335_RS02265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F0335_RS02270	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
F0335_RS02280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F0335_RS02285	COG0456	acetyltransferase
F0335_RS02295	COG2927	DNA polymerase III (CHI subunit)
F0335_RS02300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0335_RS02305	COG0795	lipopolysaccharide-transporting ATPase activity
F0335_RS02310	COG0795	lipopolysaccharide-transporting ATPase activity
F0335_RS02325	COG0582	viral genome integration into host DNA
F0335_RS02395	COG0582	viral genome integration into host DNA
F0335_RS02415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F0335_RS02440	COG1715	Restriction endonuclease
F0335_RS02465	COG2723	6-phospho-beta-galactosidase activity
F0335_RS02470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS02470	COG1263	PTS System
F0335_RS02475	COG1609	Transcriptional regulator
F0335_RS02485	COG0523	cobalamin synthesis protein
F0335_RS02490	COG2879	small protein
F0335_RS02495	COG1966	Carbon starvation protein
F0335_RS02500	COG0583	DNA-binding transcription factor activity
F0335_RS02520	COG1116	anion transmembrane transporter activity
F0335_RS02530	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F0335_RS02540	COG0174	glutamine synthetase
F0335_RS02585	COG0583	DNA-binding transcription factor activity
F0335_RS02590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F0335_RS02605	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0335_RS02610	COG2610	gluconate transmembrane transporter activity
F0335_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS02630	COG2207	Transcriptional regulator
F0335_RS02640	COG2207	Transcriptional regulator
F0335_RS02640	COG3708	Transcriptional regulator
F0335_RS02645	COG1376	ErfK ybiS ycfS ynhG family protein
F0335_RS02675	COG0811	peptide transport
F0335_RS02710	COG1454	alcohol dehydrogenase
F0335_RS02720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0335_RS02730	COG2267	carboxylic ester hydrolase activity
F0335_RS02760	COG1113	amino acid transport
F0335_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS02795	COG1846	Transcriptional regulator
F0335_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS02825	COG3971	2-oxopent-4-enoate hydratase activity
F0335_RS02845	COG2368	4-hydroxyphenylacetate
F0335_RS02850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F0335_RS02855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0335_RS02870	COG0179	Fumarylacetoacetate (FAA) hydrolase
F0335_RS02875	COG4948	Mandelate Racemase Muconate Lactonizing
F0335_RS02880	COG3618	amidohydrolase
F0335_RS02885	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS02890	COG3254	rhamnose metabolic process
F0335_RS02895	COG0738	Major facilitator superfamily
F0335_RS02915	COG1309	transcriptional regulator
F0335_RS02920	COG3706	GGDEF domain
F0335_RS02950	COG0667	Aldo Keto reductase
F0335_RS02955	COG2813	Specifically methylates the guanine in position
F0335_RS02960	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
F0335_RS02970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F0335_RS02975	COG2823	Periplasmic or secreted lipoprotein
F0335_RS02980	COG5487	UPF0391 membrane protein
F0335_RS02985	COG3237	CsbD-like
F0335_RS02990	COG4667	esterase of the alpha-beta hydrolase superfamily
F0335_RS02995	COG0084	hydrolase, TatD family'
F0335_RS03000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0335_RS03005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0335_RS03015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F0335_RS03020	COG0813	purine-nucleoside phosphorylase activity
F0335_RS03025	COG3550	peptidyl-serine autophosphorylation
F0335_RS03030	COG3726	membrane protein affecting hemolysin expression
F0335_RS03035	COG0560	Phosphoserine phosphatase
F0335_RS03055	COG0604	alcohol dehydrogenase
F0335_RS03065	COG2130	NADP-dependent
F0335_RS03080	COG0488	(ABC) transporter
F0335_RS03085	COG2885	chlorophyll binding
F0335_RS03090	COG2199	diguanylate cyclase activity
F0335_RS03100	COG0741	lytic transglycosylase activity
F0335_RS03105	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
F0335_RS03110	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
F0335_RS03115	COG0406	alpha-ribazole phosphatase activity
F0335_RS03120	COG3708	Transcriptional regulator
F0335_RS03120	COG2207	Transcriptional regulator
F0335_RS03125	COG3045	CreA protein
F0335_RS03130	COG0745	RESPONSE REGULATOR receiver
F0335_RS03160	COG3022	response to hydroperoxide
F0335_RS03165	COG1115	amino acid carrier protein
F0335_RS03170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0335_RS03175	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0335_RS03185	COG1584	GPR1 FUN34 yaaH family protein
F0335_RS03190	COG0443	Heat shock 70 kDa protein
F0335_RS03195	COG0484	heat shock protein binding
F0335_RS03200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0335_RS03205	COG0583	DNA-binding transcription factor activity
F0335_RS03210	COG0268	Binds directly to 16S ribosomal RNA
F0335_RS03220	COG0196	riboflavin kinase activity
F0335_RS03225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F0335_RS03230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0335_RS03235	COG1047	Peptidyl-prolyl cis-trans
F0335_RS03240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0335_RS03265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0335_RS03270	COG0505	Belongs to the CarA family
F0335_RS03275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0335_RS03295	COG2966	Psort location CytoplasmicMembrane, score
F0335_RS03305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F0335_RS03315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0335_RS03320	COG2967	ApaG domain
F0335_RS03325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0335_RS03330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F0335_RS03340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F0335_RS03350	COG0564	pseudouridine synthase activity
F0335_RS03355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0335_RS03360	COG0417	DNA replication proofreading
F0335_RS03365	COG0586	Pfam SNARE associated Golgi protein
F0335_RS03370	COG0440	acetolactate synthase activity
F0335_RS03375	COG0028	Belongs to the TPP enzyme family
F0335_RS03390	COG1178	ABC-type Fe3 transport system permease component
F0335_RS03395	COG4143	(ABC) transporter
F0335_RS03410	COG2814	Major facilitator Superfamily
F0335_RS03415	COG0471	metal ion transport
F0335_RS03420	COG0066	3-isopropylmalate dehydratase activity
F0335_RS03425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0335_RS03430	COG0473	3-isopropylmalate dehydrogenase activity
F0335_RS03435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0335_RS03450	COG1022	Amp-dependent synthetase and ligase
F0335_RS03455	COG0028	Belongs to the TPP enzyme family
F0335_RS03475	COG2001	Belongs to the MraZ family
F0335_RS03480	COG0275	rRNA processing
F0335_RS03485	COG3116	cell division
F0335_RS03490	COG0768	penicillin binding
F0335_RS03495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0335_RS03500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0335_RS03505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0335_RS03515	COG0772	Belongs to the SEDS family
F0335_RS03520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0335_RS03525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0335_RS03535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F0335_RS03540	COG0849	cell division
F0335_RS03545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0335_RS03565	COG0653	protein targeting
F0335_RS03570	COG0494	nUDIX hydrolase
F0335_RS03575	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F0335_RS03580	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
F0335_RS03585	COG0237	dephospho-CoA kinase activity
F0335_RS03590	COG0516	GMP reductase activity
F0335_RS03595	COG1459	type II secretion system
F0335_RS03600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0335_RS03605	COG4969	Belongs to the N-Me-Phe pilin family
F0335_RS03615	COG3023	N-Acetylmuramoyl-L-alanine amidase
F0335_RS03620	COG3725	Membrane protein required for beta-lactamase induction
F0335_RS03625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0335_RS03635	COG0316	Belongs to the HesB IscA family
F0335_RS03645	COG2860	membrane
F0335_RS03655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0335_RS03660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F0335_RS03665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0335_RS03675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0335_RS03680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0335_RS03685	COG3956	TIGRFAM MazG family protein
F0335_RS03690	COG0504	CTP synthase activity
F0335_RS03720	COG2986	histidine ammonia-lyase
F0335_RS03725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0335_RS03735	COG0602	queuosine metabolic process
F0335_RS03740	COG0720	synthase
F0335_RS03745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0335_RS03750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0335_RS03755	COG0175	sulfate reduction
F0335_RS03760	COG2234	aminopeptidase activity
F0335_RS03765	COG1648	precorrin-2 dehydrogenase activity
F0335_RS03765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0335_RS03770	COG0175	sulfate reduction
F0335_RS03775	COG2895	sulfate adenylyltransferase (ATP) activity
F0335_RS03790	COG1126	abc transporter atp-binding protein
F0335_RS03795	COG0765	amino acid transport
F0335_RS03805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F0335_RS03810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F0335_RS03815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F0335_RS03820	COG0585	pseudouridine synthase activity
F0335_RS03830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F0335_RS03835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0335_RS03840	COG4942	peptidase
F0335_RS03840	COG1388	LysM domain
F0335_RS03860	COG0667	Aldo Keto reductase
F0335_RS03875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0335_RS03880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0335_RS03885	COG2723	6-phospho-beta-galactosidase activity
F0335_RS03915	COG2137	regulation of response to DNA damage stimulus
F0335_RS03920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0335_RS03925	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F0335_RS03945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0335_RS03950	COG1238	metal cluster binding
F0335_RS03955	COG2918	glutathione biosynthetic process
F0335_RS03965	COG4536	flavin adenine dinucleotide binding
F0335_RS03970	COG4137	Cytochrome C assembly protein
F0335_RS03975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F0335_RS03980	COG0228	four-way junction DNA binding
F0335_RS03985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0335_RS03995	COG0335	large ribosomal subunit rRNA binding
F0335_RS04020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0335_RS04025	COG0287	Prephenate dehydrogenase
F0335_RS04025	COG1605	Chorismate mutase
F0335_RS04030	COG0077	Prephenate dehydratase
F0335_RS04030	COG1605	Chorismate mutase
F0335_RS04035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0335_RS04040	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0335_RS04045	COG0564	pseudouridine synthase activity
F0335_RS04055	COG0542	response to heat
F0335_RS04090	COG0656	L-ascorbic acid biosynthetic process
F0335_RS04095	COG0583	DNA-binding transcription factor activity
F0335_RS04100	COG3021	interspecies interaction between organisms
F0335_RS04105	COG0741	lytic transglycosylase activity
F0335_RS04105	COG1388	LysM domain
F0335_RS04115	COG2226	methyltransferase
F0335_RS04120	COG0328	RNA-DNA hybrid ribonuclease activity
F0335_RS04125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0335_RS04150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0335_RS04165	COG0436	Aminotransferase
F0335_RS04170	COG0235	Class ii aldolase
F0335_RS04175	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
F0335_RS04180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F0335_RS04185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F0335_RS04190	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
F0335_RS04200	COG1960	acyl-CoA dehydrogenase activity
F0335_RS04205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0335_RS04210	COG0121	glutamine amidotransferase
F0335_RS04215	COG3034	peptidoglycan biosynthetic process
F0335_RS04220	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0335_RS04225	COG1805	sodium ion transport
F0335_RS04230	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0335_RS04235	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0335_RS04240	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0335_RS04245	COG2871	sodium ion transport
F0335_RS04250	COG1477	protein flavinylation
F0335_RS04255	COG2991	Protein conserved in bacteria
F0335_RS04275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0335_RS04280	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0335_RS04285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F0335_RS04315	COG2314	TM2 domain
F0335_RS04345	COG3038	cytochrome b561
F0335_RS04350	COG0747	negative chemotaxis
F0335_RS04355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F0335_RS04360	COG1733	regulation of RNA biosynthetic process
F0335_RS04365	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0335_RS04380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0335_RS04385	COG2207	Transcriptional regulator
F0335_RS04390	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS04400	COG2169	Transcriptional regulator
F0335_RS04400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0335_RS04420	COG3961	Belongs to the TPP enzyme family
F0335_RS04450	COG1349	DNA-binding transcription factor activity
F0335_RS04455	COG0346	lactoylglutathione lyase activity
F0335_RS04470	COG1335	isochorismatase
F0335_RS04480	COG3011	Protein conserved in bacteria
F0335_RS04490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0335_RS04495	COG3416	Protein conserved in bacteria
F0335_RS04505	COG2226	methyltransferase
F0335_RS04555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0335_RS04575	COG1595	DNA-templated transcription, initiation
F0335_RS04610	COG3123	guanosine phosphorylase activity
F0335_RS04615	COG2974	May be involved in recombination
F0335_RS04620	COG1940	carbohydrate kinase activity
F0335_RS04640	COG0419	ATPase involved in DNA repair
F0335_RS04645	COG0420	3'-5' exonuclease activity
F0335_RS04650	COG0745	RESPONSE REGULATOR receiver
F0335_RS04655	COG5002	protein histidine kinase activity
F0335_RS04675	COG3093	addiction module antidote protein HigA
F0335_RS04690	COG0668	transmembrane transport
F0335_RS04695	COG0366	Alpha amylase catalytic
F0335_RS04705	COG0450	alkyl hydroperoxide reductase
F0335_RS04710	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
F0335_RS04715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0335_RS04720	COG0343	queuine tRNA-ribosyltransferase activity
F0335_RS04725	COG1862	Preprotein translocase
F0335_RS04735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0335_RS04740	COG4238	major outer membrane lipoprotein
F0335_RS04745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0335_RS04750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0335_RS04750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0335_RS04755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0335_RS04760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0335_RS04765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F0335_RS04770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F0335_RS04775	COG0667	Aldo Keto reductase
F0335_RS04780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0335_RS04785	COG0142	geranyltranstransferase activity
F0335_RS04790	COG1722	exodeoxyribonuclease VII activity
F0335_RS04795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0335_RS04795	COG0301	tRNA thio-modification
F0335_RS04800	COG0693	protein deglycase activity
F0335_RS04805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F0335_RS04810	COG1666	GTP binding
F0335_RS04815	COG2814	Major facilitator Superfamily
F0335_RS04820	COG0109	protoheme IX farnesyltransferase activity
F0335_RS04825	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F0335_RS04830	COG1845	cytochrome c oxidase, subunit III
F0335_RS04835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F0335_RS04840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F0335_RS04845	COG2223	nitrite transmembrane transporter activity
F0335_RS04850	COG3056	Lipoprotein
F0335_RS04855	COG0271	Belongs to the BolA IbaG family
F0335_RS04860	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0335_RS04870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0335_RS04875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0335_RS04885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0335_RS04890	COG1555	photosystem II stabilization
F0335_RS04895	COG0824	Thioesterase
F0335_RS04900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F0335_RS04905	COG4533	DNA binding
F0335_RS04910	COG0561	phosphatase activity
F0335_RS04920	COG1522	sequence-specific DNA binding
F0335_RS04925	COG1132	(ABC) transporter
F0335_RS04930	COG1132	(ABC) transporter
F0335_RS04935	COG0347	Belongs to the P(II) protein family
F0335_RS04940	COG0004	ammonium transporteR
F0335_RS04945	COG1946	Acyl-CoA thioesterase
F0335_RS04950	COG3126	Type III secretion system lipoprotein chaperone (YscW)
F0335_RS04955	COG3695	enzyme binding
F0335_RS04980	COG1121	(ABC) transporter
F0335_RS04985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0335_RS04990	COG0803	Belongs to the bacterial solute-binding protein 9 family
F0335_RS04995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0335_RS05000	COG0254	rRNA binding
F0335_RS05005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0335_RS05010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0335_RS05015	COG1309	transcriptional regulator
F0335_RS05020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F0335_RS05025	COG1196	nuclear chromosome segregation
F0335_RS05025	COG3264	Mechanosensitive ion channel
F0335_RS05040	COG2832	Protein of unknown function (DUF454)
F0335_RS05045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0335_RS05050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F0335_RS05060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0335_RS05065	COG0326	Molecular chaperone. Has ATPase activity
F0335_RS05070	COG0563	adenylate kinase activity
F0335_RS05075	COG3835	regulator
F0335_RS05080	COG2610	gluconate transmembrane transporter activity
F0335_RS05085	COG1929	Belongs to the glycerate kinase type-1 family
F0335_RS05090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0335_RS05095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0335_RS05100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0335_RS05100	COG4651	solute:proton antiporter activity
F0335_RS05105	COG2223	nitrite transmembrane transporter activity
F0335_RS05110	COG0737	Belongs to the 5'-nucleotidase family
F0335_RS05115	COG2027	D-alanyl-D-alanine carboxypeptidase
F0335_RS05120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0335_RS05125	COG3735	TraB family
F0335_RS05130	COG2217	Heavy metal translocating P-type atpase
F0335_RS05135	COG0789	Transcriptional regulator
F0335_RS05140	COG1585	Membrane protein implicated in regulation of membrane protease activity
F0335_RS05145	COG0330	HflC and HflK could
F0335_RS05150	COG0583	DNA-binding transcription factor activity
F0335_RS05165	COG3960	tartronate-semialdehyde synthase activity
F0335_RS05170	COG3622	Belongs to the hyi family
F0335_RS05175	COG2084	Dehydrogenase
F0335_RS05180	COG2271	Major facilitator Superfamily
F0335_RS05185	COG1929	Belongs to the glycerate kinase type-1 family
F0335_RS05190	COG3257	ureidoglycine aminohydrolase activity
F0335_RS05200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0335_RS05205	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F0335_RS05210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F0335_RS05215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F0335_RS05225	COG0549	Belongs to the carbamate kinase family
F0335_RS05230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0335_RS05235	COG3118	belongs to the thioredoxin family
F0335_RS05240	COG0300	oxidoreductase activity
F0335_RS05245	COG2755	lipolytic protein G-D-S-L family
F0335_RS05250	COG4181	ATPase activity
F0335_RS05255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F0335_RS05260	COG2814	Major facilitator Superfamily
F0335_RS05265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F0335_RS05270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F0335_RS05275	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0335_RS05280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0335_RS05285	COG0215	cysteine-tRNA ligase activity
F0335_RS05290	COG2501	S4 domain
F0335_RS05295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0335_RS05325	COG0667	Aldo Keto reductase
F0335_RS05340	COG2199	diguanylate cyclase activity
F0335_RS05345	COG1278	Cold shock
F0335_RS05360	COG0765	amino acid transport
F0335_RS05375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0335_RS05390	COG2814	Major facilitator Superfamily
F0335_RS05395	COG1309	transcriptional regulator
F0335_RS05400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0335_RS05410	COG3706	GGDEF domain
F0335_RS05420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0335_RS05425	COG0321	lipoyl(octanoyl) transferase activity
F0335_RS05435	COG1686	Belongs to the peptidase S11 family
F0335_RS05440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0335_RS05445	COG0772	Belongs to the SEDS family
F0335_RS05450	COG0768	penicillin binding
F0335_RS05455	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F0335_RS05460	COG0799	negative regulation of ribosome biogenesis
F0335_RS05465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0335_RS05470	COG1466	dna polymerase III delta subunit
F0335_RS05475	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F0335_RS05480	COG0495	leucyl-tRNA aminoacylation
F0335_RS05485	COG2888	peptidyl-tyrosine sulfation
F0335_RS05495	COG1957	nucleoside hydrolase
F0335_RS05500	COG1126	abc transporter atp-binding protein
F0335_RS05505	COG0765	amino acid transport
F0335_RS05520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F0335_RS05525	COG4535	Mg2 and Co2 transporter CorC
F0335_RS05530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0335_RS05535	COG1702	phosphate starvation-inducible protein PhoH
F0335_RS05540	COG2824	Alkylphosphonate utilization operon protein PhnA
F0335_RS05545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0335_RS05550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0335_RS05585	COG0367	asparagine synthase
F0335_RS05590	COG3469	chitinase activity
F0335_RS05595	COG0647	UMP catabolic process
F0335_RS05600	COG1846	Transcriptional regulator
F0335_RS05600	COG1940	carbohydrate kinase activity
F0335_RS05605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0335_RS05610	COG0363	glucosamine-6-phosphate deaminase activity
F0335_RS05615	COG2190	(PTS) system
F0335_RS05615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS05615	COG1263	PTS System
F0335_RS05620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0335_RS05640	COG0735	belongs to the Fur family
F0335_RS05655	COG0596	Alpha beta hydrolase
F0335_RS05660	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
F0335_RS05665	COG0033	Phosphoglucomutase
F0335_RS05670	COG1695	Transcriptional regulator
F0335_RS05680	COG0745	RESPONSE REGULATOR receiver
F0335_RS05685	COG2205	protein histidine kinase activity
F0335_RS05690	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F0335_RS05695	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F0335_RS05700	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F0335_RS05715	COG3272	Protein of unknown function (DUF1722)
F0335_RS05725	COG5212	phosphodiesterase
F0335_RS05730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0335_RS05735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F0335_RS05740	COG1984	allophanate hydrolase subunit 2
F0335_RS05745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F0335_RS05765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0335_RS05780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F0335_RS05785	COG1053	succinate dehydrogenase
F0335_RS05790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0335_RS05795	COG0567	Dehydrogenase, E1 component
F0335_RS05800	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0335_RS05805	COG0045	succinate-CoA ligase (ADP-forming) activity
F0335_RS05810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F0335_RS05820	COG1271	oxidase subunit
F0335_RS05825	COG1294	oxidase, subunit
F0335_RS05830	COG4890	Cyd operon protein YbgT
F0335_RS05835	COG3790	cyd operon protein YbgE
F0335_RS05840	COG0824	Thioesterase
F0335_RS05845	COG0811	peptide transport
F0335_RS05850	COG0848	biopolymer transport protein
F0335_RS05855	COG3064	Membrane
F0335_RS05860	COG0823	Involved in the tonB-independent uptake of proteins
F0335_RS05865	COG2885	chlorophyll binding
F0335_RS05870	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
F0335_RS05915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F0335_RS05925	COG1230	cation diffusion facilitator family transporter
F0335_RS05930	COG2205	protein histidine kinase activity
F0335_RS05930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0335_RS05935	COG2197	response regulator
F0335_RS05940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0335_RS05955	COG0588	phosphoglycerate mutase activity
F0335_RS05965	COG2017	converts alpha-aldose to the beta-anomer
F0335_RS05970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0335_RS05975	COG1085	galactose-1-phosphate uridylyltransferase
F0335_RS05990	COG1119	ATPase activity
F0335_RS05995	COG3585	molybdate ion transport
F0335_RS05995	COG2005	Transcriptional regulator
F0335_RS06000	COG4774	siderophore transport
F0335_RS06010	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F0335_RS06015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0335_RS06020	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0335_RS06030	COG0725	ABC transporter, periplasmic molybdate-binding protein
F0335_RS06035	COG4149	molybdate abc transporter
F0335_RS06045	COG0561	phosphatase activity
F0335_RS06050	COG2706	6-phosphogluconolactonase activity
F0335_RS06055	COG1881	PFAM PEBP family protein
F0335_RS06095	COG0556	nucleotide-excision repair
F0335_RS06100	COG4628	conserved protein (DUF2132)
F0335_RS06105	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F0335_RS06110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0335_RS06115	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0335_RS06120	COG0315	cyclic pyranopterin monophosphate synthase activity
F0335_RS06125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F0335_RS06130	COG0314	molybdopterin synthase activity
F0335_RS06135	COG0670	Belongs to the BI1 family
F0335_RS06140	COG0842	Transport permease protein
F0335_RS06145	COG0842	Transport permease protein
F0335_RS06150	COG1131	(ABC) transporter
F0335_RS06155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0335_RS06160	COG1309	transcriptional regulator
F0335_RS06165	COG0513	Belongs to the DEAD box helicase family
F0335_RS06170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0335_RS06175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0335_RS06185	COG3842	ATPase activity
F0335_RS06195	COG1840	ABC-type Fe3 transport system, periplasmic component
F0335_RS06200	COG2271	Major facilitator Superfamily
F0335_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS06225	COG0583	DNA-binding transcription factor activity
F0335_RS06245	COG0583	DNA-binding transcription factor activity
F0335_RS06250	COG0586	Pfam SNARE associated Golgi protein
F0335_RS06260	COG4977	sequence-specific DNA binding
F0335_RS06265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F0335_RS06300	COG2354	Protein conserved in bacteria
F0335_RS06310	COG1464	Belongs to the NlpA lipoprotein family
F0335_RS06320	COG0456	acetyltransferase
F0335_RS06345	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0335_RS06355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0335_RS06365	COG0840	transmembrane signaling receptor activity
F0335_RS06370	COG0277	FAD linked oxidase domain protein
F0335_RS06385	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0335_RS06395	COG0436	Aminotransferase
F0335_RS06405	COG1472	Belongs to the glycosyl hydrolase 3 family
F0335_RS06450	COG2134	cdp-diacylglycerol pyrophosphatase
F0335_RS06480	COG1192	Involved in chromosome partitioning
F0335_RS06490	COG0583	DNA-binding transcription factor activity
F0335_RS06500	COG1070	Carbohydrate kinase
F0335_RS06505	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F0335_RS06510	COG0697	spore germination
F0335_RS06565	COG1309	transcriptional regulator
F0335_RS06570	COG1464	Belongs to the NlpA lipoprotein family
F0335_RS06575	COG2011	ABC-type metal ion transport system permease component
F0335_RS06580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0335_RS06585	COG0519	Catalyzes the synthesis of GMP from XMP
F0335_RS06605	COG2084	Dehydrogenase
F0335_RS06620	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
F0335_RS06635	COG4807	Protein conserved in bacteria
F0335_RS06655	COG1802	Transcriptional regulator
F0335_RS06675	COG0411	ABC transporter
F0335_RS06710	COG0583	DNA-binding transcription factor activity
F0335_RS06715	COG2897	thiosulfate sulfurtransferase activity
F0335_RS06720	COG0494	nUDIX hydrolase
F0335_RS06725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0335_RS06735	COG0625	glutathione transferase activity
F0335_RS06745	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F0335_RS06755	COG1335	isochorismatase
F0335_RS06760	COG0583	DNA-binding transcription factor activity
F0335_RS06775	COG1732	Glycine betaine
F0335_RS06780	COG1174	glycine betaine transport
F0335_RS06785	COG1125	glycine betaine transport
F0335_RS06790	COG1174	glycine betaine transport
F0335_RS06815	COG0583	DNA-binding transcription factor activity
F0335_RS06825	COG0697	spore germination
F0335_RS06870	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
F0335_RS06885	COG0625	glutathione transferase activity
F0335_RS06890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0335_RS06895	COG1942	4-Oxalocrotonate Tautomerase
F0335_RS06905	COG1522	sequence-specific DNA binding
F0335_RS06930	COG2079	MmgE PrpD family protein
F0335_RS06935	COG1280	lysine exporter protein (LysE YggA)
F0335_RS06945	COG0477	Major facilitator Superfamily
F0335_RS06955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0335_RS06975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F0335_RS06980	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
F0335_RS06995	COG1309	transcriptional regulator
F0335_RS07000	COG1214	PFAM Peptidase M22, glycoprotease
F0335_RS07000	COG0456	acetyltransferase
F0335_RS07010	COG0668	transmembrane transport
F0335_RS07015	COG1126	abc transporter atp-binding protein
F0335_RS07020	COG0765	amino acid transport
F0335_RS07025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0335_RS07030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F0335_RS07040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0335_RS07045	COG2731	YhcH YjgK YiaL family protein
F0335_RS07055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F0335_RS07060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0335_RS07075	COG2610	gluconate transmembrane transporter activity
F0335_RS07080	COG3622	Belongs to the hyi family
F0335_RS07085	COG0235	Class ii aldolase
F0335_RS07090	COG3395	kinase activity
F0335_RS07095	COG2084	Dehydrogenase
F0335_RS07100	COG1349	DNA-binding transcription factor activity
F0335_RS07110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F0335_RS07115	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
F0335_RS07155	COG3188	usher protein
F0335_RS07170	COG5002	protein histidine kinase activity
F0335_RS07175	COG0745	RESPONSE REGULATOR receiver
F0335_RS07180	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
F0335_RS07185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F0335_RS07200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0335_RS07205	COG1309	transcriptional regulator
F0335_RS07210	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS07215	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F0335_RS07220	COG0069	glutamate synthase activity
F0335_RS07230	COG2200	EAL domain
F0335_RS07240	COG3121	Chaperone
F0335_RS07245	COG3188	usher protein
F0335_RS07255	COG2207	Transcriptional regulator
F0335_RS07255	COG3708	Transcriptional regulator
F0335_RS07260	COG0579	oxidoreductase
F0335_RS07270	COG0625	glutathione transferase activity
F0335_RS07275	COG0640	Transcriptional regulator
F0335_RS07290	COG0583	DNA-binding transcription factor activity
F0335_RS07305	COG3811	Belongs to the UPF0386 family
F0335_RS07310	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
F0335_RS07320	COG0583	DNA-binding transcription factor activity
F0335_RS07330	COG0488	(ABC) transporter
F0335_RS07335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0335_RS07340	COG0303	'Molybdopterin
F0335_RS07360	COG0747	negative chemotaxis
F0335_RS07365	COG0601	transmembrane transport
F0335_RS07370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0335_RS07395	COG0583	DNA-binding transcription factor activity
F0335_RS07400	COG0477	Major facilitator Superfamily
F0335_RS07405	COG0302	gtp cyclohydrolase
F0335_RS07410	COG2311	Membrane
F0335_RS07415	COG1609	Transcriptional regulator
F0335_RS07440	COG2949	membrane
F0335_RS07445	COG0281	malic enzyme
F0335_RS07450	COG0295	cytidine deaminase activity
F0335_RS07455	COG1346	cytolysis
F0335_RS07460	COG1380	Effector of murein hydrolase LrgA
F0335_RS07475	COG3206	protein involved in exopolysaccharide biosynthesis
F0335_RS07475	COG0489	protein tyrosine kinase activity
F0335_RS07495	COG2814	Major facilitator Superfamily
F0335_RS07505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0335_RS07505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0335_RS07510	COG0489	protein tyrosine kinase activity
F0335_RS07520	COG0572	uridine kinase
F0335_RS07525	COG0717	Belongs to the dCTP deaminase family
F0335_RS07530	COG2982	Protein involved in outer membrane biogenesis
F0335_RS07535	COG3069	C4-dicarboxylate transmembrane transporter activity
F0335_RS07540	COG1253	flavin adenine dinucleotide binding
F0335_RS07545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F0335_RS07550	COG0438	transferase activity, transferring glycosyl groups
F0335_RS07555	COG2244	polysaccharide biosynthetic process
F0335_RS07560	COG0438	transferase activity, transferring glycosyl groups
F0335_RS07580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0335_RS07615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0335_RS07660	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0335_RS07665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0335_RS07665	COG0140	phosphoribosyl-ATP diphosphatase activity
F0335_RS07670	COG0107	imidazoleglycerol-phosphate synthase activity
F0335_RS07675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0335_RS07690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0335_RS07695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0335_RS07700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0335_RS07710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0335_RS07715	COG0583	DNA-binding transcription factor activity
F0335_RS07735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0335_RS07740	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F0335_RS07745	COG3153	acetyltransferase
F0335_RS07745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0335_RS07780	COG0598	Magnesium transport protein CorA
F0335_RS07790	COG2133	pyrroloquinoline quinone binding
F0335_RS07795	COG0625	glutathione transferase activity
F0335_RS07815	COG0626	cystathionine gamma-synthase activity
F0335_RS07825	COG1686	Belongs to the peptidase S11 family
F0335_RS07850	COG3539	Fimbrial protein
F0335_RS07855	COG3188	usher protein
F0335_RS07860	COG3121	Chaperone
F0335_RS07880	COG0545	Peptidyl-prolyl cis-trans isomerase
F0335_RS07885	COG2197	response regulator
F0335_RS07890	COG1760	l-serine dehydratase
F0335_RS07895	COG0814	amino acid
F0335_RS07900	COG1349	DNA-binding transcription factor activity
F0335_RS07905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0335_RS07915	COG0671	phosphoesterase, PA-phosphatase related
F0335_RS07930	COG4574	serine-type endopeptidase inhibitor activity
F0335_RS07940	COG3395	kinase activity
F0335_RS07945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F0335_RS07970	COG1595	DNA-templated transcription, initiation
F0335_RS07975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0335_RS07980	COG0569	domain protein
F0335_RS07980	COG2985	domain, Protein
F0335_RS08000	COG0189	ligase activity
F0335_RS08010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0335_RS08015	COG3842	ATPase activity
F0335_RS08020	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0335_RS08025	COG1177	transmembrane transport
F0335_RS08035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0335_RS08040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0335_RS08045	COG4160	amino acid transport
F0335_RS08050	COG4215	(ABC) transporter
F0335_RS08055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0335_RS08060	COG1126	abc transporter atp-binding protein
F0335_RS08070	COG0393	Putative heavy-metal-binding
F0335_RS08080	COG3023	N-Acetylmuramoyl-L-alanine amidase
F0335_RS08085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0335_RS08090	COG0702	epimerase
F0335_RS08105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS08105	COG2190	(PTS) system
F0335_RS08105	COG1263	PTS System
F0335_RS08110	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
F0335_RS08115	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
F0335_RS08120	COG0028	Belongs to the TPP enzyme family
F0335_RS08125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0335_RS08130	COG1151	hydroxylamine reductase activity
F0335_RS08135	COG2431	L-lysine efflux transmembrane transporter activity
F0335_RS08140	COG3593	DNA synthesis involved in DNA repair
F0335_RS08145	COG2990	Protein conserved in bacteria
F0335_RS08150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0335_RS08160	COG1278	Cold shock
F0335_RS08165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F0335_RS08170	COG0542	response to heat
F0335_RS08175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0335_RS08180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F0335_RS08185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F0335_RS08200	COG0583	DNA-binding transcription factor activity
F0335_RS08205	COG0492	ferredoxin-NADP+ reductase activity
F0335_RS08215	COG3107	peptidoglycan biosynthetic process
F0335_RS08215	COG1674	ftsk spoiiie
F0335_RS08220	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F0335_RS08225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F0335_RS08230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0335_RS08240	COG2814	Major facilitator Superfamily
F0335_RS08245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0335_RS08250	COG1882	Formate acetyltransferase
F0335_RS08255	COG2116	formate transmembrane transporter activity
F0335_RS08260	COG1944	ATP diphosphatase activity
F0335_RS08265	COG0252	asparaginase activity
F0335_RS08270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0335_RS08275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F0335_RS08280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0335_RS08285	COG0539	negative regulation of cytoplasmic translation
F0335_RS08295	COG2333	competence protein COMEC
F0335_RS08295	COG0658	competence protein
F0335_RS08300	COG1132	(ABC) transporter
F0335_RS08305	COG1663	tetraacyldisaccharide 4'-kinase activity
F0335_RS08310	COG5383	Protein conserved in bacteria
F0335_RS08320	COG1278	Cold shock
F0335_RS08325	COG3214	Protein conserved in bacteria
F0335_RS08330	COG2835	tetraacyldisaccharide 4'-kinase activity
F0335_RS08335	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F0335_RS08340	COG3173	Aminoglycoside phosphotransferase
F0335_RS08345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0335_RS08350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0335_RS08355	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
F0335_RS08365	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F0335_RS08370	COG2989	Protein conserved in bacteria
F0335_RS08375	COG3108	Peptidase M15
F0335_RS08380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0335_RS08385	COG1448	Aminotransferase
F0335_RS08395	COG0017	Asparaginyl-tRNA synthetase
F0335_RS08400	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F0335_RS08405	COG3706	GGDEF domain
F0335_RS08415	COG0308	aminopeptidase N
F0335_RS08425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F0335_RS08430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0335_RS08435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F0335_RS08440	COG0431	NADPH-dependent FMN reductase
F0335_RS08445	COG0167	dihydroorotate dehydrogenase activity
F0335_RS08455	COG0633	Ferredoxin
F0335_RS08455	COG3217	Mosc domain protein beta barrel domain protein
F0335_RS08460	COG0116	Belongs to the methyltransferase superfamily
F0335_RS08460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0335_RS08465	COG0488	(ABC) transporter
F0335_RS08470	COG2995	paraquat-inducible protein a
F0335_RS08475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0335_RS08475	COG3008	intermembrane lipid transfer
F0335_RS08480	COG3009	Protein conserved in bacteria
F0335_RS08485	COG3130	regulation of translation
F0335_RS08490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0335_RS08500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0335_RS08505	COG1067	ATP-dependent peptidase activity
F0335_RS08525	COG3070	regulator of competence-specific genes
F0335_RS08530	COG1289	transmembrane transporter activity
F0335_RS08535	COG3304	Inner membrane component domain
F0335_RS08540	COG0210	DNA helicase
F0335_RS08545	COG1803	Methylglyoxal synthase
F0335_RS08555	COG1832	CoA-binding protein
F0335_RS08560	COG3785	DNA binding
F0335_RS08565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0335_RS08570	COG1254	Belongs to the acylphosphatase family
F0335_RS08575	COG2920	part of a sulfur-relay system
F0335_RS08580	COG0670	Belongs to the BI1 family
F0335_RS08600	COG0789	Transcriptional regulator
F0335_RS08610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0335_RS08625	COG0655	NAD(P)H dehydrogenase (quinone) activity
F0335_RS08645	COG1113	amino acid transport
F0335_RS08660	COG2271	Major facilitator Superfamily
F0335_RS08680	COG2814	Major facilitator Superfamily
F0335_RS08685	COG2197	response regulator
F0335_RS08690	COG0589	response to stress
F0335_RS08705	COG0531	amino acid
F0335_RS08710	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS08715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0335_RS08760	COG3136	membrane protein required for alginate biosynthesis
F0335_RS08770	COG2197	response regulator
F0335_RS08775	COG0322	excinuclease ABC activity
F0335_RS08800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0335_RS08845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0335_RS08850	COG0322	excinuclease ABC activity
F0335_RS08885	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F0335_RS08890	COG2943	transferase activity, transferring hexosyl groups
F0335_RS08895	COG5645	(Lipo)protein
F0335_RS08915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0335_RS08925	COG0640	Transcriptional regulator
F0335_RS08940	COG0346	lactoylglutathione lyase activity
F0335_RS08945	COG3104	oligopeptide transport
F0335_RS08950	COG2814	Major facilitator Superfamily
F0335_RS08960	COG1560	Kdo2-lipid A biosynthetic process
F0335_RS08975	COG2353	YceI-like domain
F0335_RS08980	COG3038	cytochrome b561
F0335_RS08985	COG0628	permease
F0335_RS09030	COG0418	dihydroorotase activity
F0335_RS09035	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F0335_RS09040	COG1530	ribonuclease E activity
F0335_RS09045	COG0564	pseudouridine synthase activity
F0335_RS09055	COG1399	metal-binding, possibly nucleic acid-binding protein
F0335_RS09060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0335_RS09065	COG0416	fatty acid biosynthetic process
F0335_RS09070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0335_RS09075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F0335_RS09085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0335_RS09090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0335_RS09095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0335_RS09100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0335_RS09105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0335_RS09110	COG0470	DNA polymerase III
F0335_RS09115	COG0084	hydrolase, TatD family'
F0335_RS09120	COG1263	PTS System
F0335_RS09120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS09140	COG1321	iron dependent repressor
F0335_RS09145	COG1914	H( )-stimulated, divalent metal cation uptake system
F0335_RS09150	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS09155	COG1733	regulation of RNA biosynthetic process
F0335_RS09165	COG0537	adenosine 5'-monophosphoramidase activity
F0335_RS09170	COG5633	Lipoprotein
F0335_RS09175	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
F0335_RS09180	COG0510	thiamine kinase activity
F0335_RS09190	COG3150	esterase
F0335_RS09195	COG1252	NADH dehydrogenase
F0335_RS09200	COG3134	Outer membrane lipoprotein
F0335_RS09220	COG2207	Transcriptional regulator
F0335_RS09220	COG3708	Transcriptional regulator
F0335_RS09245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0335_RS09250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F0335_RS09255	COG3381	protein complex oligomerization
F0335_RS09260	COG2979	Protein of unknown function (DUF533)
F0335_RS09265	COG1770	oligopeptidase
F0335_RS09270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0335_RS09290	COG1528	Iron-storage protein
F0335_RS09295	COG2372	response to copper ion
F0335_RS09300	COG1276	copper resistance
F0335_RS09375	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0335_RS09390	COG4565	transcriptional regulatory protein
F0335_RS09395	COG3290	protein histidine kinase activity
F0335_RS09410	COG1129	ABC transporter
F0335_RS09415	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS09430	COG1464	Belongs to the NlpA lipoprotein family
F0335_RS09440	COG0589	response to stress
F0335_RS09445	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
F0335_RS09445	COG3408	Glycogen debranching enzyme
F0335_RS09455	COG1609	Transcriptional regulator
F0335_RS09460	COG3250	beta-galactosidase activity
F0335_RS09465	COG2731	YhcH YjgK YiaL family protein
F0335_RS09470	COG0531	amino acid
F0335_RS09475	COG0640	Transcriptional regulator
F0335_RS09485	COG0740	serine-type endopeptidase activity
F0335_RS09495	COG3121	Chaperone
F0335_RS09505	COG3188	usher protein
F0335_RS09510	COG3121	Chaperone
F0335_RS09525	COG1733	regulation of RNA biosynthetic process
F0335_RS09535	COG0583	DNA-binding transcription factor activity
F0335_RS09545	COG0012	GTP binding
F0335_RS09550	COG0659	secondary active sulfate transmembrane transporter activity
F0335_RS09555	COG0193	aminoacyl-tRNA hydrolase activity
F0335_RS09565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0335_RS09570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F0335_RS09575	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F0335_RS09585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F0335_RS09590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0335_RS09595	COG2890	protein-(glutamine-N5) methyltransferase activity
F0335_RS09600	COG3094	Invasion gene expression up-regulator, SirB
F0335_RS09605	COG2912	Transglutaminase-like superfamily
F0335_RS09610	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F0335_RS09615	COG0659	secondary active sulfate transmembrane transporter activity
F0335_RS09620	COG4702	Belongs to the UPF0303 family
F0335_RS09625	COG3706	GGDEF domain
F0335_RS09630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F0335_RS09635	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0335_RS09645	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0335_RS09670	COG1486	melibiose metabolic process
F0335_RS09675	COG1263	PTS System
F0335_RS09675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS09680	COG1177	transmembrane transport
F0335_RS09700	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0335_RS09705	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F0335_RS09720	COG2850	peptidyl-arginine hydroxylation
F0335_RS09730	COG0745	RESPONSE REGULATOR receiver
F0335_RS09735	COG1397	ADP-ribosylglycohydrolase
F0335_RS09740	COG2188	Transcriptional regulator
F0335_RS09755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0335_RS09760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F0335_RS09765	COG2915	High frequency lysogenization protein hflD homolog
F0335_RS09775	COG0482	sulfurtransferase activity
F0335_RS09790	COG1187	pseudouridine synthase activity
F0335_RS09795	COG0538	isocitrate dehydrogenase activity
F0335_RS09815	COG0582	viral genome integration into host DNA
F0335_RS09830	COG1403	HNH endonuclease
F0335_RS09865	COG4220	transposase activity
F0335_RS09915	COG3064	Membrane
F0335_RS09985	COG1278	Cold shock
F0335_RS09995	COG1335	isochorismatase
F0335_RS10000	COG0589	response to stress
F0335_RS10005	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS10010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0335_RS10015	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS10020	COG1917	Cupin 2, conserved barrel domain protein
F0335_RS10020	COG1396	sequence-specific DNA binding
F0335_RS10025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F0335_RS10030	COG0174	glutamine synthetase
F0335_RS10065	COG1605	Chorismate mutase
F0335_RS10080	COG1228	amidohydrolase
F0335_RS10090	COG0402	S-adenosylhomocysteine deaminase activity
F0335_RS10110	COG2211	Major facilitator Superfamily
F0335_RS10115	COG0477	Major facilitator Superfamily
F0335_RS10135	COG0583	DNA-binding transcription factor activity
F0335_RS10145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F0335_RS10155	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F0335_RS10215	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
F0335_RS10215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0335_RS10220	COG3008	intermembrane lipid transfer
F0335_RS10225	COG2995	paraquat-inducible protein a
F0335_RS10230	COG1956	GAF domain-containing protein
F0335_RS10235	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F0335_RS10240	COG0793	Belongs to the peptidase S41A family
F0335_RS10245	COG0501	Belongs to the peptidase M48B family
F0335_RS10255	COG2814	Major facilitator Superfamily
F0335_RS10260	COG1414	Transcriptional regulator
F0335_RS10285	COG2188	Transcriptional regulator
F0335_RS10305	COG1988	membrane-bound metal-dependent
F0335_RS10310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0335_RS10325	COG3001	Fructosamine kinase
F0335_RS10330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0335_RS10335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0335_RS10340	COG1121	(ABC) transporter
F0335_RS10345	COG0803	Belongs to the bacterial solute-binding protein 9 family
F0335_RS10375	COG0814	amino acid
F0335_RS10405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F0335_RS10415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0335_RS10420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0335_RS10430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0335_RS10450	COG4139	cobalamin transport
F0335_RS10455	COG0386	Belongs to the glutathione peroxidase family
F0335_RS10465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0335_RS10470	COG1215	transferase activity, transferring glycosyl groups
F0335_RS10475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0335_RS10475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0335_RS10480	COG0726	polysaccharide deacetylase
F0335_RS10485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F0335_RS10490	COG2076	Multidrug Resistance protein
F0335_RS10495	COG2076	Multidrug Resistance protein
F0335_RS10500	COG0791	NLP P60 protein
F0335_RS10505	COG0095	Lipoate-protein ligase
F0335_RS10525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0335_RS10530	COG4558	Periplasmic binding protein
F0335_RS10535	COG3720	iron ion transport
F0335_RS10550	COG0386	Belongs to the glutathione peroxidase family
F0335_RS10560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F0335_RS10565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0335_RS10565	COG0574	Belongs to the PEP-utilizing enzyme family
F0335_RS10575	COG0628	permease
F0335_RS10580	COG0247	lactate metabolic process
F0335_RS10580	COG0277	FAD linked oxidase domain protein
F0335_RS10585	COG2050	protein possibly involved in aromatic compounds catabolism
F0335_RS10595	COG0316	Belongs to the HesB IscA family
F0335_RS10600	COG0719	Fe-S assembly protein
F0335_RS10605	COG0396	ATPase activity
F0335_RS10610	COG0719	Fe-S assembly protein
F0335_RS10615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0335_RS10620	COG2166	iron-sulfur cluster assembly
F0335_RS10625	COG1388	LysM domain
F0335_RS10625	COG1376	ErfK ybiS ycfS ynhG family protein
F0335_RS10635	COG0469	pyruvate kinase activity
F0335_RS10660	COG0534	Mate efflux family protein
F0335_RS10665	COG0307	riboflavin synthase, alpha
F0335_RS10675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0335_RS10680	COG2814	Major facilitator Superfamily
F0335_RS10685	COG0583	DNA-binding transcription factor activity
F0335_RS10690	COG1609	Transcriptional regulator
F0335_RS10705	COG0791	NLP P60 protein
F0335_RS10710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F0335_RS10720	COG0346	lactoylglutathione lyase activity
F0335_RS10725	COG1902	pentaerythritol trinitrate reductase activity
F0335_RS10730	COG1309	transcriptional regulator
F0335_RS10735	COG2194	sulfuric ester hydrolase activity
F0335_RS10745	COG0583	DNA-binding transcription factor activity
F0335_RS10750	COG3313	Fe-S protein
F0335_RS10755	COG4989	oxidoreductase activity
F0335_RS10760	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F0335_RS10770	COG1289	transmembrane transporter activity
F0335_RS10775	COG1566	PFAM secretion protein HlyD family protein
F0335_RS10785	COG1846	Transcriptional regulator
F0335_RS10790	COG3133	Outer membrane lipoprotein
F0335_RS10795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F0335_RS10805	COG0259	pyridoxamine-phosphate oxidase activity
F0335_RS10810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0335_RS10825	COG0625	glutathione transferase activity
F0335_RS10875	COG3135	benzoate transporter
F0335_RS10880	COG1396	sequence-specific DNA binding
F0335_RS10885	COG1505	serine-type exopeptidase activity
F0335_RS10890	COG3104	oligopeptide transport
F0335_RS10895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F0335_RS10905	COG4659	FMN binding
F0335_RS10915	COG2207	Transcriptional regulator
F0335_RS10915	COG3708	Transcriptional regulator
F0335_RS10920	COG4656	Part of a membrane complex involved in electron transport
F0335_RS10925	COG2878	Part of a membrane complex involved in electron transport
F0335_RS10930	COG4657	Part of a membrane complex involved in electron transport
F0335_RS10940	COG0673	inositol 2-dehydrogenase activity
F0335_RS10945	COG0385	Bile acid
F0335_RS10955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0335_RS10965	COG0494	nUDIX hydrolase
F0335_RS10975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F0335_RS10980	COG1263	PTS System
F0335_RS10980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS10985	COG1609	Transcriptional regulator
F0335_RS11005	COG0583	DNA-binding transcription factor activity
F0335_RS11015	COG5339	Protein conserved in bacteria
F0335_RS11035	COG0114	fumarate hydratase activity
F0335_RS11040	COG2378	regulation of single-species biofilm formation
F0335_RS11065	COG2814	Major facilitator Superfamily
F0335_RS11075	COG1940	carbohydrate kinase activity
F0335_RS11080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0335_RS11090	COG0789	Transcriptional regulator
F0335_RS11135	COG1742	UPF0060 membrane protein
F0335_RS11140	COG4221	oxidoreductase activity
F0335_RS11150	COG4772	TonB-dependent receptor
F0335_RS11160	COG1595	DNA-templated transcription, initiation
F0335_RS11165	COG0402	S-adenosylhomocysteine deaminase activity
F0335_RS11225	COG0339	signal peptide processing
F0335_RS11230	COG2271	Major facilitator Superfamily
F0335_RS11235	COG1335	isochorismatase
F0335_RS11240	COG3473	Maleate cis-trans isomerase
F0335_RS11245	COG0596	Alpha beta hydrolase
F0335_RS11250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0335_RS11255	COG2309	aminopeptidase activity
F0335_RS11260	COG1846	Transcriptional regulator
F0335_RS11265	COG2080	2 iron, 2 sulfur cluster binding
F0335_RS11270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0335_RS11270	COG2010	Cytochrome c
F0335_RS11280	COG0583	DNA-binding transcription factor activity
F0335_RS11315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F0335_RS11315	COG2755	lipolytic protein G-D-S-L family
F0335_RS11345	COG4221	oxidoreductase activity
F0335_RS11350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F0335_RS11360	COG1280	lysine exporter protein (LysE YggA)
F0335_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS11385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0335_RS11405	COG1073	alpha beta
F0335_RS11410	COG2140	Oxalate decarboxylase
F0335_RS11415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS11415	COG2190	(PTS) system
F0335_RS11415	COG1263	PTS System
F0335_RS11420	COG2723	6-phospho-beta-galactosidase activity
F0335_RS11425	COG3711	transcriptional antiterminator
F0335_RS11460	COG0596	Alpha beta hydrolase
F0335_RS11470	COG3209	COG3209 Rhs family protein
F0335_RS11505	COG0384	phenazine biosynthesis protein PhzF
F0335_RS11535	COG2814	Major facilitator Superfamily
F0335_RS11555	COG0768	penicillin binding
F0335_RS11575	COG0840	transmembrane signaling receptor activity
F0335_RS11600	COG0583	DNA-binding transcription factor activity
F0335_RS11610	COG2814	Major facilitator Superfamily
F0335_RS11620	COG1349	DNA-binding transcription factor activity
F0335_RS11625	COG0673	inositol 2-dehydrogenase activity
F0335_RS11655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0335_RS11660	COG2862	Uncharacterized protein family, UPF0114
F0335_RS11665	COG2814	Major facilitator Superfamily
F0335_RS11670	COG0583	DNA-binding transcription factor activity
F0335_RS11680	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0335_RS11690	COG3453	Protein conserved in bacteria
F0335_RS11690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0335_RS11695	COG1064	alcohol dehydrogenase
F0335_RS11700	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS11705	COG3284	Transcriptional regulator
F0335_RS11720	COG2814	Major facilitator Superfamily
F0335_RS11725	COG5001	Diguanylate cyclase
F0335_RS11725	COG3300	MHYT domain
F0335_RS11745	COG1802	Transcriptional regulator
F0335_RS11755	COG2267	carboxylic ester hydrolase activity
F0335_RS11760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F0335_RS11765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0335_RS11770	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS11775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F0335_RS11825	COG0076	glutamate decarboxylase activity
F0335_RS11830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F0335_RS11835	COG1902	pentaerythritol trinitrate reductase activity
F0335_RS11835	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0335_RS11845	COG0148	phosphopyruvate hydratase activity
F0335_RS11855	COG1227	inorganic diphosphatase activity
F0335_RS11900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0335_RS11910	COG0477	Major facilitator Superfamily
F0335_RS11915	COG1309	transcriptional regulator
F0335_RS11925	COG4774	siderophore transport
F0335_RS11940	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F0335_RS11945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0335_RS11975	COG1082	Xylose isomerase domain protein TIM barrel
F0335_RS11980	COG0673	inositol 2-dehydrogenase activity
F0335_RS12010	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F0335_RS12010	COG0456	acetyltransferase
F0335_RS12020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0335_RS12065	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0335_RS12070	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0335_RS12075	COG1733	regulation of RNA biosynthetic process
F0335_RS12080	COG0477	Major facilitator Superfamily
F0335_RS12095	COG2382	esterase
F0335_RS12100	COG4774	siderophore transport
F0335_RS12110	COG1113	amino acid transport
F0335_RS12115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F0335_RS12120	COG0318	PFAM AMP-dependent synthetase and ligase
F0335_RS12125	COG0693	protein deglycase activity
F0335_RS12140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0335_RS12160	COG2957	Belongs to the agmatine deiminase family
F0335_RS12165	COG0583	DNA-binding transcription factor activity
F0335_RS12175	COG0243	molybdopterin cofactor binding
F0335_RS12195	COG0778	Nitroreductase
F0335_RS12200	COG2010	Cytochrome c
F0335_RS12200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0335_RS12205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0335_RS12205	COG2010	Cytochrome c
F0335_RS12210	COG2080	2 iron, 2 sulfur cluster binding
F0335_RS12225	COG1737	Transcriptional regulator
F0335_RS12230	COG2723	6-phospho-beta-galactosidase activity
F0335_RS12235	COG3048	D-serine ammonia-lyase activity
F0335_RS12250	COG5507	3-demethylubiquinone-9 3-methyltransferase
F0335_RS12255	COG2199	diguanylate cyclase activity
F0335_RS12275	COG3264	Mechanosensitive ion channel
F0335_RS12275	COG1196	nuclear chromosome segregation
F0335_RS12280	COG0488	(ABC) transporter
F0335_RS12295	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F0335_RS12310	COG2239	Acts as a magnesium transporter
F0335_RS12360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0335_RS12365	COG0697	spore germination
F0335_RS12460	COG0306	phosphate transporter
F0335_RS12480	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F0335_RS12485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0335_RS12505	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F0335_RS12510	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
F0335_RS12535	COG1175	transmembrane transport
F0335_RS12540	COG0395	ABC-type sugar transport system, permease component
F0335_RS12545	COG3842	ATPase activity
F0335_RS12550	COG0673	inositol 2-dehydrogenase activity
F0335_RS12555	COG1940	carbohydrate kinase activity
F0335_RS12560	COG1349	DNA-binding transcription factor activity
F0335_RS12565	COG2222	sugar isomerase
F0335_RS12580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0335_RS12590	COG0589	response to stress
F0335_RS12595	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F0335_RS12600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F0335_RS12610	COG0531	amino acid
F0335_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS12635	COG0745	RESPONSE REGULATOR receiver
F0335_RS12640	COG2205	protein histidine kinase activity
F0335_RS12645	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F0335_RS12650	COG2267	carboxylic ester hydrolase activity
F0335_RS12660	COG3591	Belongs to the peptidase S1B family
F0335_RS12665	COG2207	Transcriptional regulator
F0335_RS12670	COG2814	Major facilitator Superfamily
F0335_RS12675	COG1643	Atp-dependent helicase
F0335_RS12680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F0335_RS12685	COG3784	Protein of unknown function (DUF1318)
F0335_RS12695	COG2911	Protein conserved in bacteria
F0335_RS12700	COG0583	DNA-binding transcription factor activity
F0335_RS12710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0335_RS12715	COG3187	Heat shock protein
F0335_RS12720	COG3042	response to heat
F0335_RS12730	COG1013	pyruvate-flavodoxin oxidoreductase activity
F0335_RS12730	COG0674	pyruvate-flavodoxin oxidoreductase activity
F0335_RS12730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0335_RS12730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F0335_RS12735	COG0037	tRNA processing
F0335_RS12765	COG4166	transmembrane transport
F0335_RS12775	COG2866	Carboxypeptidase
F0335_RS12780	COG4948	Mandelate Racemase Muconate Lactonizing
F0335_RS12785	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F0335_RS12795	COG3768	UPF0283 membrane protein
F0335_RS12800	COG3106	COG3106 Predicted ATPase
F0335_RS12810	COG1983	PspC domain protein
F0335_RS12820	COG1842	Phage shock protein A
F0335_RS12825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F0335_RS12830	COG0738	Major facilitator superfamily
F0335_RS12835	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS12850	COG1469	GTP cyclohydrolase I activity
F0335_RS12865	COG4171	peptide transport system, permease
F0335_RS12870	COG4172	Belongs to the ABC transporter superfamily
F0335_RS12875	COG4172	Belongs to the ABC transporter superfamily
F0335_RS12885	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0335_RS12885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0335_RS12905	COG0243	molybdopterin cofactor binding
F0335_RS12920	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
F0335_RS12925	COG0477	Major facilitator Superfamily
F0335_RS12930	COG1473	amidohydrolase
F0335_RS12935	COG1966	Carbon starvation protein
F0335_RS12940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0335_RS12945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0335_RS12950	COG1882	Formate acetyltransferase
F0335_RS12955	COG1349	DNA-binding transcription factor activity
F0335_RS12965	COG0023	Translation Initiation Factor
F0335_RS12985	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F0335_RS12990	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F0335_RS12995	COG0671	phosphoesterase, PA-phosphatase related
F0335_RS13005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F0335_RS13020	COG0583	DNA-binding transcription factor activity
F0335_RS13035	COG0616	signal peptide processing
F0335_RS13040	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS13045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F0335_RS13050	COG1187	pseudouridine synthase activity
F0335_RS13065	COG0009	L-threonylcarbamoyladenylate synthase
F0335_RS13070	COG0613	PHP domain protein
F0335_RS13085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0335_RS13095	COG0133	tryptophan synthase activity
F0335_RS13100	COG0159	tryptophan synthase activity
F0335_RS13115	COG0727	PFAM Uncharacterised protein family (UPF0153)
F0335_RS13130	COG2917	probably involved in intracellular septation
F0335_RS13135	COG1607	acyl-coa hydrolase
F0335_RS13145	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0335_RS13150	COG2350	Protein conserved in bacteria
F0335_RS13170	COG0583	DNA-binding transcription factor activity
F0335_RS13180	COG1609	Transcriptional regulator
F0335_RS13195	COG1070	Carbohydrate kinase
F0335_RS13200	COG1129	ABC transporter
F0335_RS13205	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS13210	COG1879	ABC-type sugar transport system periplasmic component
F0335_RS13225	COG0783	Belongs to the Dps family
F0335_RS13235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0335_RS13240	COG3099	Belongs to the UPF0263 family
F0335_RS13250	COG0444	Belongs to the ABC transporter superfamily
F0335_RS13255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0335_RS13270	COG4166	transmembrane transport
F0335_RS13275	COG2095	MarC family integral membrane protein
F0335_RS13280	COG1454	alcohol dehydrogenase
F0335_RS13280	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS13305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F0335_RS13310	COG0745	RESPONSE REGULATOR receiver
F0335_RS13315	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0335_RS13320	COG3012	SEC-C Motif Domain Protein
F0335_RS13325	COG0788	formyltetrahydrofolate deformylase activity
F0335_RS13360	COG0708	Exodeoxyribonuclease III
F0335_RS13365	COG0494	nUDIX hydrolase
F0335_RS13375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0335_RS13380	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
F0335_RS13390	COG0778	Nitroreductase
F0335_RS13395	COG0616	signal peptide processing
F0335_RS13400	COG0252	asparaginase activity
F0335_RS13405	COG1335	isochorismatase
F0335_RS13415	COG3139	Protein of unknown function (DUF1315)
F0335_RS13420	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0335_RS13435	COG3713	MltA-interacting MipA family protein
F0335_RS13450	COG2718	Belongs to the UPF0229 family
F0335_RS13495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0335_RS13500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0335_RS13510	COG3443	Belongs to the bacterial solute-binding protein 9 family
F0335_RS13515	COG2719	SpoVR family
F0335_RS13520	COG2186	Transcriptional regulator
F0335_RS13525	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0335_RS13530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F0335_RS13535	COG2983	Belongs to the UPF0260 family
F0335_RS13540	COG0179	Fumarylacetoacetate (FAA) hydrolase
F0335_RS13545	COG2951	lytic endotransglycosylase activity
F0335_RS13550	COG3100	YcgL domain-containing protein
F0335_RS13555	COG0850	regulation of cytokinetic process
F0335_RS13560	COG2894	cell division
F0335_RS13565	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F0335_RS13570	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F0335_RS13575	COG0318	PFAM AMP-dependent synthetase and ligase
F0335_RS13580	COG3065	identical protein binding
F0335_RS13590	COG1199	ATP-dependent helicase activity
F0335_RS13595	COG0251	oxidation-reduction process
F0335_RS13600	COG2076	Multidrug Resistance protein
F0335_RS13605	COG2076	Multidrug Resistance protein
F0335_RS13610	COG0800	Aldolase
F0335_RS13615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F0335_RS13620	COG1737	Transcriptional regulator
F0335_RS13625	COG0469	pyruvate kinase activity
F0335_RS13635	COG1560	Kdo2-lipid A biosynthetic process
F0335_RS13640	COG0739	heme binding
F0335_RS13645	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F0335_RS13650	COG1121	(ABC) transporter
F0335_RS13655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0335_RS13660	COG2255	four-way junction helicase activity
F0335_RS13665	COG0632	four-way junction helicase activity
F0335_RS13670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F0335_RS13675	COG0217	transcriptional regulatory protein
F0335_RS13680	COG0494	nUDIX hydrolase
F0335_RS13685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0335_RS13695	COG1335	isochorismatase
F0335_RS13700	COG1801	Protein of unknown function DUF72
F0335_RS13705	COG3788	relative of glutathione S-transferase, MAPEG superfamily
F0335_RS13710	COG2226	methyltransferase
F0335_RS13715	COG0500	methyltransferase
F0335_RS13720	COG0545	Peptidyl-prolyl cis-trans isomerase
F0335_RS13730	COG3142	Participates in the control of copper homeostasis
F0335_RS13735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F0335_RS13740	COG3102	Protein conserved in bacteria
F0335_RS13745	COG0018	arginyl-trna synthetase
F0335_RS13755	COG0673	inositol 2-dehydrogenase activity
F0335_RS13760	COG3132	Protein of unknown function, DUF480
F0335_RS13765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0335_RS13770	COG0477	Major facilitator Superfamily
F0335_RS13780	COG2999	glutathione oxidoreductase activity
F0335_RS13785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F0335_RS13805	COG3141	response to X-ray
F0335_RS13810	COG0513	Belongs to the DEAD box helicase family
F0335_RS13820	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F0335_RS13825	COG3140	Belongs to the UPF0181 family
F0335_RS13840	COG0494	nUDIX hydrolase
F0335_RS13845	COG1760	l-serine dehydratase
F0335_RS13850	COG2200	EAL domain
F0335_RS13855	COG1253	flavin adenine dinucleotide binding
F0335_RS13860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS13860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS13865	COG3715	PTS system
F0335_RS13870	COG3716	PTS system mannose fructose sorbose family IID component
F0335_RS13875	COG4811	Protein of unknown function (DUF986)
F0335_RS13880	COG1971	Probably functions as a manganese efflux pump
F0335_RS13885	COG2226	methyltransferase
F0335_RS13915	COG1113	amino acid transport
F0335_RS13960	COG2207	Transcriptional regulator
F0335_RS13985	COG1652	LysM domain
F0335_RS14005	COG2988	succinylglutamate desuccinylase activity
F0335_RS14010	COG3724	N-succinylarginine dihydrolase activity
F0335_RS14015	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS14020	COG3138	arginine N-succinyltransferase
F0335_RS14025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0335_RS14035	COG4608	Belongs to the ABC transporter superfamily
F0335_RS14040	COG0444	Belongs to the ABC transporter superfamily
F0335_RS14050	COG0601	transmembrane transport
F0335_RS14060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0335_RS14065	COG1271	oxidase subunit
F0335_RS14070	COG1294	oxidase, subunit
F0335_RS14120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0335_RS14125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0335_RS14130	COG2181	nitrate reductase activity
F0335_RS14135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F0335_RS14140	COG1140	nitrate reductase beta subunit
F0335_RS14145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F0335_RS14185	COG0489	protein tyrosine kinase activity
F0335_RS14185	COG3206	protein involved in exopolysaccharide biosynthesis
F0335_RS14195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0335_RS14200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0335_RS14205	COG3710	Transcriptional regulator
F0335_RS14215	COG3850	Histidine kinase
F0335_RS14220	COG2197	response regulator
F0335_RS14225	COG4932	domain protein
F0335_RS14230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F0335_RS14240	COG0747	negative chemotaxis
F0335_RS14245	COG4608	Belongs to the ABC transporter superfamily
F0335_RS14250	COG0444	Belongs to the ABC transporter superfamily
F0335_RS14255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0335_RS14260	COG0601	transmembrane transport
F0335_RS14270	COG0583	DNA-binding transcription factor activity
F0335_RS14275	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
F0335_RS14280	COG4572	Cation transport regulator
F0335_RS14285	COG2375	cellular response to nickel ion
F0335_RS14290	COG0387	Pfam Sodium calcium exchanger
F0335_RS14300	COG1702	phosphate starvation-inducible protein PhoH
F0335_RS14310	COG2822	iron ion transport
F0335_RS14315	COG0672	)-iron permease
F0335_RS14325	COG0506	proline dehydrogenase activity
F0335_RS14325	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F0335_RS14325	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F0335_RS14345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F0335_RS14355	COG1191	sigma factor activity
F0335_RS14385	COG0583	DNA-binding transcription factor activity
F0335_RS14400	COG1677	Flagellar hook-basal body complex protein FliE
F0335_RS14410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F0335_RS14415	COG1317	bacterial-type flagellum organization
F0335_RS14420	COG1157	protein secretion by the type III secretion system
F0335_RS14425	COG2882	bacterial-type flagellum organization
F0335_RS14430	COG3144	bacterial-type flagellum assembly
F0335_RS14480	COG1256	bacterial-type flagellum assembly
F0335_RS14515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F0335_RS14520	COG1558	bacterial-type flagellum-dependent cell motility
F0335_RS14525	COG1815	bacterial-type flagellum-dependent cell motility
F0335_RS14535	COG2747	anti-sigma28 factor FlgM
F0335_RS14540	COG3418	PFAM FlgN family protein
F0335_RS14560	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F0335_RS14565	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F0335_RS14570	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
F0335_RS14575	COG0745	RESPONSE REGULATOR receiver
F0335_RS14585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0335_RS14590	COG0840	transmembrane signaling receptor activity
F0335_RS14595	COG0840	transmembrane signaling receptor activity
F0335_RS14600	COG0835	chemotaxis
F0335_RS14605	COG0643	Histidine kinase
F0335_RS14605	COG2198	Histidine kinase
F0335_RS14640	COG0589	response to stress
F0335_RS14645	COG2130	NADP-dependent
F0335_RS14650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
F0335_RS14660	COG3501	Rhs element vgr protein
F0335_RS14820	COG3501	Rhs element vgr protein
F0335_RS14830	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
F0335_RS14835	COG3483	tryptophan 2,3-dioxygenase activity
F0335_RS14840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0335_RS14850	COG3059	membrane
F0335_RS14855	COG2207	Transcriptional regulator
F0335_RS14860	COG1609	Transcriptional regulator
F0335_RS14895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0335_RS14905	COG3712	iron ion homeostasis
F0335_RS14910	COG1595	DNA-templated transcription, initiation
F0335_RS14915	COG1629	transport
F0335_RS14920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0335_RS14945	COG3781	membrane
F0335_RS14950	COG2837	iron assimilation
F0335_RS14960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F0335_RS14970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F0335_RS14995	COG1285	pathogenesis
F0335_RS15010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0335_RS15020	COG0076	glutamate decarboxylase activity
F0335_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS15055	COG3321	synthase
F0335_RS15055	COG0604	alcohol dehydrogenase
F0335_RS15065	COG0583	DNA-binding transcription factor activity
F0335_RS15070	COG3753	Protein conserved in bacteria
F0335_RS15075	COG2261	transglycosylase associated protein
F0335_RS15085	COG1560	Kdo2-lipid A biosynthetic process
F0335_RS15090	COG2764	glyoxalase bleomycin resistance protein dioxygenase
F0335_RS15100	COG5001	Diguanylate cyclase
F0335_RS15100	COG4251	negative regulation of phosphorylation
F0335_RS15100	COG3706	GGDEF domain
F0335_RS15100	COG2203	Gaf domain
F0335_RS15110	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS15110	COG2030	dehydratase
F0335_RS15115	COG3396	Phenylacetate-CoA oxygenase
F0335_RS15120	COG3460	Phenylacetate-CoA oxygenase
F0335_RS15125	COG3396	Phenylacetate-CoA oxygenase
F0335_RS15130	COG2151	metal-sulfur cluster biosynthetic enzyme
F0335_RS15135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0335_RS15140	COG1024	Enoyl-CoA hydratase
F0335_RS15145	COG1024	Enoyl-CoA hydratase
F0335_RS15150	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0335_RS15155	COG2050	protein possibly involved in aromatic compounds catabolism
F0335_RS15160	COG0183	Belongs to the thiolase family
F0335_RS15165	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F0335_RS15170	COG3327	negative regulation of DNA-templated transcription, initiation
F0335_RS15175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F0335_RS15190	COG1113	amino acid transport
F0335_RS15195	COG1448	Aminotransferase
F0335_RS15210	COG0583	DNA-binding transcription factor activity
F0335_RS15215	COG0625	glutathione transferase activity
F0335_RS15255	COG0667	Aldo Keto reductase
F0335_RS15260	COG4772	TonB-dependent receptor
F0335_RS15265	COG4993	Dehydrogenase
F0335_RS15300	COG3539	Fimbrial protein
F0335_RS15310	COG3121	Chaperone
F0335_RS15315	COG3188	usher protein
F0335_RS15320	COG3539	Fimbrial protein
F0335_RS15340	COG0534	Mate efflux family protein
F0335_RS15370	COG3228	Belongs to the MtfA family
F0335_RS15380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0335_RS15385	COG4977	sequence-specific DNA binding
F0335_RS15395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0335_RS15400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F0335_RS15405	COG1116	anion transmembrane transporter activity
F0335_RS15410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F0335_RS15415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F0335_RS15430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0335_RS15450	COG3238	Protein conserved in bacteria
F0335_RS15455	COG1247	-acetyltransferase
F0335_RS15475	COG0583	DNA-binding transcription factor activity
F0335_RS15485	COG0859	PFAM glycosyl transferase family 9
F0335_RS15505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0335_RS15525	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS15530	COG1169	isochorismate synthase
F0335_RS15545	COG0471	metal ion transport
F0335_RS15550	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F0335_RS15560	COG3051	citrate lyase alpha subunit
F0335_RS15565	COG2301	Belongs to the HpcH HpaI aldolase family
F0335_RS15570	COG3052	prosthetic group binding
F0335_RS15575	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F0335_RS15585	COG3250	beta-galactosidase activity
F0335_RS15595	COG0300	oxidoreductase activity
F0335_RS15600	COG2207	Transcriptional regulator
F0335_RS15610	COG0667	Aldo Keto reductase
F0335_RS15645	COG2197	response regulator
F0335_RS15655	COG1121	(ABC) transporter
F0335_RS15675	COG2814	Major facilitator Superfamily
F0335_RS15700	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F0335_RS15725	COG2070	2-Nitropropane dioxygenase
F0335_RS15745	COG2271	Major facilitator Superfamily
F0335_RS15775	COG0411	ABC transporter
F0335_RS15800	COG0702	epimerase
F0335_RS15805	COG1073	alpha beta
F0335_RS15810	COG1073	alpha beta
F0335_RS15815	COG0583	DNA-binding transcription factor activity
F0335_RS15845	COG0583	DNA-binding transcription factor activity
F0335_RS15865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0335_RS15870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0335_RS15875	COG0156	8-amino-7-oxononanoate synthase activity
F0335_RS15880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0335_RS15885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0335_RS15890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0335_RS15895	COG2244	polysaccharide biosynthetic process
F0335_RS15905	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F0335_RS15910	COG0795	lipopolysaccharide-transporting ATPase activity
F0335_RS15935	COG0583	DNA-binding transcription factor activity
F0335_RS15950	COG1609	Transcriptional regulator
F0335_RS15960	COG3623	hexulose-6-phosphate isomerase
F0335_RS15965	COG1070	Carbohydrate kinase
F0335_RS15970	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS15980	COG1879	ABC-type sugar transport system periplasmic component
F0335_RS15985	COG1063	alcohol dehydrogenase
F0335_RS15995	COG1473	amidohydrolase
F0335_RS16000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0335_RS16005	COG2926	Belongs to the UPF0265 family
F0335_RS16010	COG1289	transmembrane transporter activity
F0335_RS16015	COG3023	N-Acetylmuramoyl-L-alanine amidase
F0335_RS16040	COG2925	Exonuclease
F0335_RS16045	COG0531	amino acid
F0335_RS16050	COG0174	glutamine synthetase
F0335_RS16055	COG1396	sequence-specific DNA binding
F0335_RS16055	COG1917	Cupin 2, conserved barrel domain protein
F0335_RS16060	COG1129	ABC transporter
F0335_RS16065	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS16070	COG4771	TonB-dependent receptor
F0335_RS16085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0335_RS16095	COG0833	amino acid
F0335_RS16100	COG0583	DNA-binding transcription factor activity
F0335_RS16110	COG2855	membrane
F0335_RS16115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0335_RS16125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0335_RS16125	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F0335_RS16125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0335_RS16130	COG1105	Belongs to the carbohydrate kinase PfkB family
F0335_RS16135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS16135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS16140	COG0494	nUDIX hydrolase
F0335_RS16145	COG3005	denitrification pathway
F0335_RS16150	COG0243	molybdopterin cofactor binding
F0335_RS16170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0335_RS16175	COG1312	Catalyzes the dehydration of D-mannonate
F0335_RS16180	COG0246	Mannitol dehydrogenase
F0335_RS16190	COG0523	cobalamin synthesis protein
F0335_RS16195	COG0671	phosphoesterase, PA-phosphatase related
F0335_RS16200	COG0791	NLP P60 protein
F0335_RS16205	COG2200	EAL domain
F0335_RS16210	COG4166	transmembrane transport
F0335_RS16215	COG4174	ABC transporter (Permease)
F0335_RS16220	COG4239	(ABC) transporter, permease
F0335_RS16225	COG4172	Belongs to the ABC transporter superfamily
F0335_RS16235	COG2814	Major facilitator Superfamily
F0335_RS16240	COG1187	pseudouridine synthase activity
F0335_RS16245	COG1061	Type III restriction enzyme res subunit
F0335_RS16250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F0335_RS16255	COG3081	Nucleoid-associated protein
F0335_RS16260	COG3082	Protein of unknown function (DUF1414)
F0335_RS16265	COG3083	sulfuric ester hydrolase activity
F0335_RS16310	COG5301	cellulose 1,4-beta-cellobiosidase activity
F0335_RS16395	COG3772	lysozyme
F0335_RS16425	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0335_RS16440	COG0346	lactoylglutathione lyase activity
F0335_RS16455	COG2223	nitrite transmembrane transporter activity
F0335_RS16460	COG2198	Histidine kinase
F0335_RS16460	COG0642	Histidine kinase
F0335_RS16470	COG0784	Response regulator, receiver
F0335_RS16470	COG2205	protein histidine kinase activity
F0335_RS16480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0335_RS16485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0335_RS16495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0335_RS16520	COG0814	amino acid
F0335_RS16535	COG0318	PFAM AMP-dependent synthetase and ligase
F0335_RS16545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F0335_RS16550	COG0596	Alpha beta hydrolase
F0335_RS16555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F0335_RS16560	COG4575	ribosome binding
F0335_RS16570	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS16575	COG1609	Transcriptional regulator
F0335_RS16605	COG0028	Belongs to the TPP enzyme family
F0335_RS16610	COG0583	DNA-binding transcription factor activity
F0335_RS16615	COG1007	ATP synthesis coupled electron transport
F0335_RS16620	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0335_RS16625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0335_RS16630	COG0713	ATP synthesis coupled electron transport
F0335_RS16635	COG0839	Belongs to the complex I subunit 6 family
F0335_RS16645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0335_RS16650	COG1034	ATP synthesis coupled electron transport
F0335_RS16665	COG0649	NAD binding
F0335_RS16665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0335_RS16670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0335_RS16675	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0335_RS16680	COG0583	DNA-binding transcription factor activity
F0335_RS16685	COG0436	Aminotransferase
F0335_RS16690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F0335_RS16695	COG0490	domain, Protein
F0335_RS16695	COG0471	metal ion transport
F0335_RS16700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0335_RS16705	COG3013	Belongs to the UPF0304 family
F0335_RS16710	COG3092	negative regulation of chromosome organization
F0335_RS16715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0335_RS16720	COG0280	phosphate acetyltransferase
F0335_RS16720	COG0857	belongs to the CobB CobQ family
F0335_RS16740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0335_RS16745	COG3959	Transketolase, thiamine diphosphate binding domain
F0335_RS16750	COG3037	sugar-specific permease SgaT UlaA
F0335_RS16760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS16765	COG1609	Transcriptional regulator
F0335_RS16770	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F0335_RS16775	COG0622	Phosphoesterase
F0335_RS16780	COG0625	glutathione transferase activity
F0335_RS16785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0335_RS16790	COG1090	epimerase
F0335_RS16795	COG4598	ABC transporter
F0335_RS16805	COG4215	(ABC) transporter
F0335_RS16810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0335_RS16815	COG0163	prenyltransferase activity
F0335_RS16820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F0335_RS16825	COG1286	toxin biosynthetic process
F0335_RS16830	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
F0335_RS16835	COG0285	dihydrofolate synthase activity
F0335_RS16840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0335_RS16845	COG0586	Pfam SNARE associated Golgi protein
F0335_RS16855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0335_RS16860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0335_RS16870	COG0697	spore germination
F0335_RS16875	COG0642	Histidine kinase
F0335_RS16915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0335_RS16920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0335_RS16960	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0335_RS16980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0335_RS16995	COG3101	peptidyl-lysine hydroxylation
F0335_RS17000	COG0730	response to heat
F0335_RS17005	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
F0335_RS17010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0335_RS17015	COG2890	protein-(glutamine-N5) methyltransferase activity
F0335_RS17020	COG2840	Smr protein MutS2
F0335_RS17025	COG2062	phosphohistidine phosphatase, SixA
F0335_RS17030	COG1024	Enoyl-CoA hydratase
F0335_RS17030	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0335_RS17035	COG0183	Belongs to the thiolase family
F0335_RS17040	COG3691	Protein conserved in bacteria
F0335_RS17055	COG3088	subunit of a heme lyase
F0335_RS17055	COG4235	cytochrome complex assembly
F0335_RS17060	COG4235	cytochrome complex assembly
F0335_RS17060	COG3088	subunit of a heme lyase
F0335_RS17065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0335_RS17070	COG1138	Cytochrome C-type biogenesis protein
F0335_RS17075	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F0335_RS17080	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0335_RS17085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0335_RS17090	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0335_RS17100	COG2116	formate transmembrane transporter activity
F0335_RS17115	COG2207	Transcriptional regulator
F0335_RS17115	COG3708	Transcriptional regulator
F0335_RS17130	COG2197	response regulator
F0335_RS17150	COG0583	DNA-binding transcription factor activity
F0335_RS17160	COG0697	spore germination
F0335_RS17175	COG2951	lytic endotransglycosylase activity
F0335_RS17185	COG1598	PFAM Uncharacterised protein family UPF0150
F0335_RS17195	COG3038	cytochrome b561
F0335_RS17200	COG0436	Aminotransferase
F0335_RS17220	COG3279	Response regulator of the LytR AlgR family
F0335_RS17230	COG2223	nitrite transmembrane transporter activity
F0335_RS17245	COG1794	racemase activity, acting on amino acids and derivatives
F0335_RS17255	COG0583	DNA-binding transcription factor activity
F0335_RS17260	COG3961	Belongs to the TPP enzyme family
F0335_RS17265	COG0667	Aldo Keto reductase
F0335_RS17275	COG1914	H( )-stimulated, divalent metal cation uptake system
F0335_RS17280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0335_RS17295	COG2116	formate transmembrane transporter activity
F0335_RS17300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0335_RS17330	COG4592	Periplasmic binding protein
F0335_RS17335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0335_RS17340	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0335_RS17345	COG1120	ATPase activity
F0335_RS17350	COG0747	negative chemotaxis
F0335_RS17370	COG4302	ethanolamine ammonia-lyase activity
F0335_RS17375	COG4303	Ethanolamine ammonia lyase large subunit
F0335_RS17390	COG0583	DNA-binding transcription factor activity
F0335_RS17395	COG0385	Bile acid
F0335_RS17400	COG3530	Putative quorum-sensing-regulated virulence factor
F0335_RS17405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0335_RS17410	COG3115	cell septum assembly
F0335_RS17415	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
F0335_RS17425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS17430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0335_RS17440	COG2205	protein histidine kinase activity
F0335_RS17445	COG0745	RESPONSE REGULATOR receiver
F0335_RS17460	COG4208	sulfate ABC transporter
F0335_RS17465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F0335_RS17470	COG4150	thiosulfate binding
F0335_RS17475	COG2837	iron assimilation
F0335_RS17490	COG3111	PFAM Bacterial OB fold (BOF) protein
F0335_RS17495	COG0456	acetyltransferase
F0335_RS17500	COG0860	N-Acetylmuramoyl-L-alanine amidase
F0335_RS17505	COG0408	coproporphyrinogen oxidase activity
F0335_RS17510	COG1671	Belongs to the UPF0178 family
F0335_RS17515	COG1629	transport
F0335_RS17515	COG4206	TonB-dependent receptor
F0335_RS17520	COG1770	oligopeptidase
F0335_RS17535	COG0833	amino acid
F0335_RS17540	COG2040	homocysteine
F0335_RS17570	COG0583	DNA-binding transcription factor activity
F0335_RS17575	COG3397	chitin binding
F0335_RS17580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0335_RS17585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0335_RS17590	COG0494	nUDIX hydrolase
F0335_RS17595	COG3850	Histidine kinase
F0335_RS17600	COG2197	response regulator
F0335_RS17610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0335_RS17630	COG0454	-acetyltransferase
F0335_RS17640	COG1393	Belongs to the ArsC family
F0335_RS17645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0335_RS17650	COG1876	peptidase activity
F0335_RS17660	COG0400	carboxylic ester hydrolase activity
F0335_RS17670	COG2321	neutral zinc metallopeptidase
F0335_RS17675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0335_RS17680	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
F0335_RS17685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0335_RS17690	COG2716	regulation of RNA biosynthetic process
F0335_RS17695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F0335_RS17700	COG0628	permease
F0335_RS17750	COG4783	chaperone-mediated protein folding
F0335_RS17755	COG1393	Belongs to the ArsC family
F0335_RS17765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0335_RS17775	COG2261	transglycosylase associated protein
F0335_RS17785	COG2233	PERMEase
F0335_RS17795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0335_RS17800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F0335_RS17805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0335_RS17825	COG0573	inorganic phosphate transmembrane transporter activity
F0335_RS17830	COG0573	inorganic phosphate transmembrane transporter activity
F0335_RS17835	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0335_RS17850	COG2239	Acts as a magnesium transporter
F0335_RS17855	COG3447	MASE1 domain protein
F0335_RS17855	COG5001	Diguanylate cyclase
F0335_RS17855	COG5002	protein histidine kinase activity
F0335_RS17870	COG0443	Heat shock 70 kDa protein
F0335_RS17885	COG0667	Aldo Keto reductase
F0335_RS17890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0335_RS17895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0335_RS17900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0335_RS17905	COG2814	Major facilitator Superfamily
F0335_RS17910	COG2205	protein histidine kinase activity
F0335_RS17915	COG0745	RESPONSE REGULATOR receiver
F0335_RS17930	COG3422	double-strand break repair
F0335_RS17940	COG1597	lipid kinase activity
F0335_RS17945	COG4948	Mandelate Racemase Muconate Lactonizing
F0335_RS17950	COG1063	alcohol dehydrogenase
F0335_RS17955	COG2271	Major facilitator Superfamily
F0335_RS17960	COG0246	Mannitol dehydrogenase
F0335_RS17970	COG1802	Transcriptional regulator
F0335_RS17975	COG1830	Aldolase
F0335_RS17985	COG3730	PTS system glucitol sorbitol-specific
F0335_RS18000	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS18005	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS18010	COG1349	DNA-binding transcription factor activity
F0335_RS18025	COG0351	phosphomethylpyrimidine kinase
F0335_RS18030	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F0335_RS18045	COG2814	Major facilitator Superfamily
F0335_RS18065	COG1187	pseudouridine synthase activity
F0335_RS18085	COG2205	protein histidine kinase activity
F0335_RS18085	COG5002	protein histidine kinase activity
F0335_RS18085	COG0784	Response regulator, receiver
F0335_RS18095	COG1733	regulation of RNA biosynthetic process
F0335_RS18105	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
F0335_RS18130	COG5314	conjugation
F0335_RS18160	COG0582	viral genome integration into host DNA
F0335_RS18165	COG0519	Catalyzes the synthesis of GMP from XMP
F0335_RS18165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0335_RS18170	COG0517	IMP dehydrogenase activity
F0335_RS18170	COG0516	GMP reductase activity
F0335_RS18175	COG1570	exodeoxyribonuclease VII activity
F0335_RS18185	COG2271	Major facilitator Superfamily
F0335_RS18190	COG1609	Transcriptional regulator
F0335_RS18205	COG1645	bacterial-type flagellum-dependent swarming motility
F0335_RS18215	COG1160	GTP binding
F0335_RS18220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0335_RS18225	COG2976	Protein conserved in bacteria
F0335_RS18230	COG0124	histidyl-tRNA synthetase
F0335_RS18235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0335_RS18240	COG1426	Protein conserved in bacteria
F0335_RS18250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F0335_RS18255	COG0105	UTP biosynthetic process
F0335_RS18265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0335_RS18270	COG2975	iron-sulfur cluster assembly
F0335_RS18275	COG0633	Ferredoxin
F0335_RS18280	COG0443	Heat shock 70 kDa protein
F0335_RS18285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F0335_RS18290	COG0316	Belongs to the HesB IscA family
F0335_RS18295	COG0822	iron-sulfur transferase activity
F0335_RS18300	COG1104	cysteine desulfurase activity
F0335_RS18305	COG1959	2 iron, 2 sulfur cluster binding
F0335_RS18320	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F0335_RS18325	COG3683	transport system, periplasmic component
F0335_RS18335	COG2814	Major facilitator Superfamily
F0335_RS18340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0335_RS18345	COG1017	nitric oxide dioxygenase activity
F0335_RS18345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0335_RS18355	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F0335_RS18360	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS18365	COG1177	transmembrane transport
F0335_RS18370	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0335_RS18375	COG3842	ATPase activity
F0335_RS18380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0335_RS18395	COG0347	Belongs to the P(II) protein family
F0335_RS18400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0335_RS18400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0335_RS18405	COG2204	response regulator
F0335_RS18410	COG3170	Tfp pilus assembly protein FimV
F0335_RS18415	COG2205	protein histidine kinase activity
F0335_RS18425	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F0335_RS18440	COG0560	Phosphoserine phosphatase
F0335_RS18445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS18445	COG1263	PTS System
F0335_RS18450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0335_RS18455	COG1737	Transcriptional regulator
F0335_RS18550	COG0740	serine-type endopeptidase activity
F0335_RS18585	COG3179	chitinase
F0335_RS18715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0335_RS18720	COG0736	holo-[acyl-carrier-protein] synthase activity
F0335_RS18725	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F0335_RS18730	COG1381	Involved in DNA repair and RecF pathway recombination
F0335_RS18735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0335_RS18740	COG0571	ribonuclease III activity
F0335_RS18750	COG0481	GTPase activity
F0335_RS18760	COG3086	response to oxidative stress
F0335_RS18765	COG3026	antisigma factor binding
F0335_RS18780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F0335_RS18785	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F0335_RS18790	COG0513	Belongs to the DEAD box helicase family
F0335_RS18810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0335_RS18815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0335_RS18820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0335_RS18825	COG0497	DNA recombination
F0335_RS18830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0335_RS18835	COG2914	Belongs to the UPF0125 (RnfH) family
F0335_RS18840	COG2867	negative regulation of translational initiation
F0335_RS18845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0335_RS18865	COG3182	Iron-regulated membrane protein
F0335_RS18875	COG0454	-acetyltransferase
F0335_RS18905	COG2388	GCN5-related N-acetyl-transferase
F0335_RS18910	COG3592	Divergent 4Fe-4S mono-cluster
F0335_RS18915	COG2259	Doxx family
F0335_RS18920	COG2840	Smr protein MutS2
F0335_RS18940	COG0477	Major facilitator Superfamily
F0335_RS18960	COG0477	Major facilitator Superfamily
F0335_RS18975	COG4575	ribosome binding
F0335_RS18985	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0335_RS18990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0335_RS18995	COG1780	Probably involved in ribonucleotide reductase function
F0335_RS19005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0335_RS19015	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS19025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F0335_RS19030	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0335_RS19035	COG3493	citrate carrier protein
F0335_RS19060	COG4176	ABC-type proline glycine betaine transport system permease component
F0335_RS19065	COG2113	Glycine betaine
F0335_RS19070	COG0583	DNA-binding transcription factor activity
F0335_RS19075	COG2814	Major facilitator Superfamily
F0335_RS19080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
F0335_RS19090	COG1846	Transcriptional regulator
F0335_RS19100	COG1566	PFAM secretion protein HlyD family protein
F0335_RS19105	COG2814	Major facilitator Superfamily
F0335_RS19110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0335_RS19115	COG3118	belongs to the thioredoxin family
F0335_RS19130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0335_RS19135	COG0477	Major facilitator Superfamily
F0335_RS19160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0335_RS19170	COG2011	ABC-type metal ion transport system permease component
F0335_RS19185	COG1720	tRNA m6t6A37 methyltransferase activity
F0335_RS19190	COG0442	prolyl-tRNA aminoacylation
F0335_RS19195	COG3015	lipoprotein NlpE involved in copper resistance
F0335_RS19200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F0335_RS19215	COG4568	rho-dependent transcription termination
F0335_RS19225	COG0037	tRNA processing
F0335_RS19230	COG3104	oligopeptide transport
F0335_RS19240	COG0531	amino acid
F0335_RS19245	COG3710	Transcriptional regulator
F0335_RS19250	COG0346	lactoylglutathione lyase activity
F0335_RS19260	COG0825	malonyl-CoA metabolic process
F0335_RS19265	COG0587	DNA-directed DNA polymerase activity
F0335_RS19270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0335_RS19275	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0335_RS19280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0335_RS19285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0335_RS19290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0335_RS19295	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
F0335_RS19300	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0335_RS19305	COG0750	zinc metalloprotease
F0335_RS19310	COG0575	Belongs to the CDS family
F0335_RS19315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0335_RS19320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F0335_RS19325	COG0233	cytoplasmic translational termination
F0335_RS19330	COG0528	UMP kinase activity
F0335_RS19340	COG0052	Belongs to the universal ribosomal protein uS2 family
F0335_RS19350	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F0335_RS19370	COG0564	pseudouridine synthase activity
F0335_RS19380	COG2373	Large extracellular alpha-helical protein
F0335_RS19385	COG3098	single-species biofilm formation
F0335_RS19390	COG2814	Major facilitator Superfamily
F0335_RS19405	COG1611	Belongs to the LOG family
F0335_RS19410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0335_RS19415	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
F0335_RS19420	COG2363	Small membrane protein
F0335_RS19425	COG0583	DNA-binding transcription factor activity
F0335_RS19435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0335_RS19440	COG2166	iron-sulfur cluster assembly
F0335_RS19445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F0335_RS19450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F0335_RS19470	COG0860	N-Acetylmuramoyl-L-alanine amidase
F0335_RS19475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F0335_RS19475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0335_RS19480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0335_RS19485	COG1074	ATP-dependent DNA helicase activity
F0335_RS19490	COG1025	Belongs to the peptidase M16 family
F0335_RS19495	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F0335_RS19515	COG2165	general secretion pathway protein
F0335_RS19520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F0335_RS19525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0335_RS19535	COG0494	nUDIX hydrolase
F0335_RS19540	COG3066	DNA modification
F0335_RS19555	COG0667	Aldo Keto reductase
F0335_RS19560	COG0477	Major facilitator Superfamily
F0335_RS19565	COG0204	Acyl-transferase
F0335_RS19565	COG0318	PFAM AMP-dependent synthetase and ligase
F0335_RS19575	COG3121	Chaperone
F0335_RS19600	COG1609	Transcriptional regulator
F0335_RS19610	COG0583	DNA-binding transcription factor activity
F0335_RS19615	COG0583	DNA-binding transcription factor activity
F0335_RS19645	COG3716	PTS system mannose fructose sorbose family IID component
F0335_RS19650	COG3715	PTS system
F0335_RS19655	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0335_RS19665	COG1349	DNA-binding transcription factor activity
F0335_RS19670	COG2807	transmembrane transport
F0335_RS19685	COG4615	Cyclic peptide transporter
F0335_RS19690	COG0583	DNA-binding transcription factor activity
F0335_RS19695	COG1620	l-lactate permease
F0335_RS19700	COG1304	FMN binding
F0335_RS19710	COG2814	Major facilitator Superfamily
F0335_RS19720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0335_RS19725	COG1309	transcriptional regulator
F0335_RS19730	COG5265	(ABC) transporter
F0335_RS19740	COG4942	peptidase
F0335_RS19745	COG3247	response to pH
F0335_RS19775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0335_RS19785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0335_RS19795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F0335_RS19805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F0335_RS19810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0335_RS19815	COG4974	Belongs to the 'phage' integrase family
F0335_RS19820	COG0716	FMN binding
F0335_RS19825	COG4452	Inner membrane protein CreD
F0335_RS19830	COG2205	protein histidine kinase activity
F0335_RS19835	COG0745	RESPONSE REGULATOR receiver
F0335_RS19845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F0335_RS19850	COG0354	folic acid binding
F0335_RS19860	COG1272	protein, Hemolysin III
F0335_RS19870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0335_RS19875	COG1940	carbohydrate kinase activity
F0335_RS19880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0335_RS19890	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS19895	COG1129	ABC transporter
F0335_RS19905	COG1349	DNA-binding transcription factor activity
F0335_RS19920	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS19950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0335_RS19950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0335_RS19955	COG0509	glycine decarboxylation via glycine cleavage system
F0335_RS19960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0335_RS19965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0335_RS19970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0335_RS19975	COG0006	proline dipeptidase activity
F0335_RS19980	COG3079	Belongs to the UPF0149 family
F0335_RS19985	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F0335_RS19995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0335_RS20000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0335_RS20010	COG0583	DNA-binding transcription factor activity
F0335_RS20020	COG1279	arginine transmembrane transporter activity
F0335_RS20025	COG1414	Transcriptional regulator
F0335_RS20030	COG1129	ABC transporter
F0335_RS20035	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS20055	COG2731	YhcH YjgK YiaL family protein
F0335_RS20065	COG1070	Carbohydrate kinase
F0335_RS20070	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F0335_RS20075	COG3623	hexulose-6-phosphate isomerase
F0335_RS20080	COG0235	Class ii aldolase
F0335_RS20090	COG3122	Protein conserved in bacteria
F0335_RS20105	COG2271	Major facilitator Superfamily
F0335_RS20120	COG0191	fructose-bisphosphate aldolase activity
F0335_RS20125	COG0126	phosphoglycerate kinase activity
F0335_RS20130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0335_RS20135	COG3842	ATPase activity
F0335_RS20140	COG1175	transmembrane transport
F0335_RS20155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0335_RS20165	COG1114	Component of the transport system for branched-chain amino acids
F0335_RS20170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0335_RS20175	COG0501	Belongs to the peptidase M48B family
F0335_RS20190	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
F0335_RS20195	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS20200	COG2267	carboxylic ester hydrolase activity
F0335_RS20225	COG1414	Transcriptional regulator
F0335_RS20230	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS20245	COG2146	nitrite reductase [NAD(P)H] activity
F0335_RS20250	COG2271	Major facilitator Superfamily
F0335_RS20260	COG0010	Belongs to the arginase family
F0335_RS20265	COG1166	arginine decarboxylase activity
F0335_RS20275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0335_RS20290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0335_RS20295	COG1120	ATPase activity
F0335_RS20300	COG4774	siderophore transport
F0335_RS20305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0335_RS20310	COG1643	Atp-dependent helicase
F0335_RS20315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F0335_RS20320	COG1489	DNA binding
F0335_RS20330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0335_RS20335	COG0617	tRNA 3'-terminal CCA addition
F0335_RS20340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0335_RS20345	COG0642	Histidine kinase
F0335_RS20355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0335_RS20360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0335_RS20365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F0335_RS20370	COG0726	polysaccharide deacetylase
F0335_RS20375	COG0842	Transport permease protein
F0335_RS20380	COG1131	(ABC) transporter
F0335_RS20385	COG0288	reversible hydration of carbon dioxide
F0335_RS20405	COG2132	Multicopper oxidase
F0335_RS20415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F0335_RS20420	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F0335_RS20425	COG3112	Uncharacterised protein family (UPF0231)
F0335_RS20435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0335_RS20440	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0335_RS20445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0335_RS20450	COG2186	Transcriptional regulator
F0335_RS20455	COG1113	amino acid transport
F0335_RS20460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0335_RS20460	COG2010	Cytochrome c
F0335_RS20470	COG2010	Cytochrome c
F0335_RS20470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0335_RS20480	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F0335_RS20485	COG3708	Transcriptional regulator
F0335_RS20485	COG2207	Transcriptional regulator
F0335_RS20495	COG3091	SprT-like family
F0335_RS20500	COG2356	endonuclease I
F0335_RS20505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F0335_RS20510	COG0189	ligase activity
F0335_RS20515	COG1678	Uncharacterized ACR, COG1678
F0335_RS20520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0335_RS20525	COG2805	Type II/IV secretion system protein
F0335_RS20530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0335_RS20535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0335_RS20540	COG0762	integral membrane protein
F0335_RS20545	COG1872	DUF167
F0335_RS20555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0335_RS20575	COG2066	Belongs to the glutaminase family
F0335_RS20580	COG3171	Protein conserved in bacteria
F0335_RS20585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0335_RS20595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F0335_RS20600	COG0741	lytic transglycosylase activity
F0335_RS20605	COG1982	Orn Lys Arg decarboxylase major
F0335_RS20640	COG2819	hydrolase of the alpha beta superfamily
F0335_RS20645	COG0454	-acetyltransferase
F0335_RS20685	COG4772	TonB-dependent receptor
F0335_RS20690	COG0583	DNA-binding transcription factor activity
F0335_RS20695	COG1473	amidohydrolase
F0335_RS20700	COG1473	amidohydrolase
F0335_RS20705	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F0335_RS20735	COG0848	biopolymer transport protein
F0335_RS20750	COG0586	Pfam SNARE associated Golgi protein
F0335_RS20755	COG0583	DNA-binding transcription factor activity
F0335_RS20760	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS20760	COG3321	synthase
F0335_RS20760	COG0604	alcohol dehydrogenase
F0335_RS20765	COG2207	Transcriptional regulator
F0335_RS20770	COG1979	alcohol dehydrogenase
F0335_RS20775	COG0656	L-ascorbic acid biosynthetic process
F0335_RS20790	COG2186	Transcriptional regulator
F0335_RS20800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0335_RS20805	COG2211	Major facilitator Superfamily
F0335_RS20810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F0335_RS20815	COG0583	DNA-binding transcription factor activity
F0335_RS20820	COG2132	Multicopper oxidase
F0335_RS20830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0335_RS20835	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0335_RS20840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F0335_RS20845	COG0583	DNA-binding transcription factor activity
F0335_RS20850	COG0187	DNA topoisomerase II activity
F0335_RS20855	COG3150	esterase
F0335_RS20860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F0335_RS20865	COG3151	Protein conserved in bacteria
F0335_RS20870	COG0494	nUDIX hydrolase
F0335_RS20875	COG1538	Outer membrane efflux protein
F0335_RS20885	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
F0335_RS20885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0335_RS20885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS20890	COG1461	Dihydroxyacetone kinase
F0335_RS20895	COG2376	Dihydroxyacetone kinase
F0335_RS20905	COG5463	Belongs to the UPF0441 family
F0335_RS20910	COG0754	glutathionylspermidine amidase activity
F0335_RS20915	COG3384	dioxygenase
F0335_RS20925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0335_RS20935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0335_RS20935	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0335_RS20940	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F0335_RS20945	COG3025	triphosphatase activity
F0335_RS20950	COG4991	sh3 domain protein
F0335_RS20955	COG0617	tRNA 3'-terminal CCA addition
F0335_RS20960	COG1968	undecaprenyl-diphosphatase activity
F0335_RS20965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0335_RS20970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F0335_RS20975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0335_RS20980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F0335_RS20985	COG0358	DNA primase activity
F0335_RS21030	COG0625	glutathione transferase activity
F0335_RS21040	COG1012	belongs to the aldehyde dehydrogenase family
F0335_RS21045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F0335_RS21055	COG0488	(ABC) transporter
F0335_RS21060	COG1902	pentaerythritol trinitrate reductase activity
F0335_RS21060	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0335_RS21065	COG2813	Specifically methylates the guanine in position
F0335_RS21070	COG1451	nucleotide metabolic process
F0335_RS21075	COG0673	inositol 2-dehydrogenase activity
F0335_RS21080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0335_RS21080	COG0519	Catalyzes the synthesis of GMP from XMP
F0335_RS21085	COG0861	Integral membrane protein TerC family
F0335_RS21090	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F0335_RS21095	COG2721	sulfolactate sulfo-lyase activity
F0335_RS21100	COG1904	glucuronate isomerase
F0335_RS21110	COG2271	Major facilitator Superfamily
F0335_RS21125	COG0586	Pfam SNARE associated Golgi protein
F0335_RS21130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0335_RS21140	COG4575	ribosome binding
F0335_RS21145	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
F0335_RS21155	COG2259	Doxx family
F0335_RS21160	COG0435	Glutathione S-transferase
F0335_RS21165	COG0583	DNA-binding transcription factor activity
F0335_RS21170	COG1741	Belongs to the pirin family
F0335_RS21180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F0335_RS21185	COG3107	peptidoglycan biosynthetic process
F0335_RS21190	COG0792	nuclease activity
F0335_RS21195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0335_RS21200	COG2823	Periplasmic or secreted lipoprotein
F0335_RS21210	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F0335_RS21215	COG0784	Response regulator, receiver
F0335_RS21215	COG2198	Histidine kinase
F0335_RS21215	COG5002	protein histidine kinase activity
F0335_RS21220	COG1242	4 iron, 4 sulfur cluster binding
F0335_RS21225	COG0069	glutamate synthase activity
F0335_RS21225	COG0067	glutamate synthase
F0335_RS21225	COG0070	glutamate synthase
F0335_RS21230	COG0493	'glutamate synthase
F0335_RS21240	COG2969	positive regulation of protein catabolic process
F0335_RS21245	COG0625	glutathione transferase activity
F0335_RS21250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0335_RS21255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0335_RS21260	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F0335_RS21265	COG3105	Protein conserved in bacteria
F0335_RS21270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0335_RS21275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0335_RS21280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0335_RS21285	COG5007	Belongs to the BolA IbaG family
F0335_RS21290	COG3113	response to antibiotic
F0335_RS21295	COG2854	intermembrane phospholipid transfer
F0335_RS21300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0335_RS21305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0335_RS21310	COG1127	ABC transporter
F0335_RS21315	COG0530	calcium, potassium:sodium antiporter activity
F0335_RS21320	COG0517	IMP dehydrogenase activity
F0335_RS21320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F0335_RS21325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F0335_RS21330	COG3117	lipopolysaccharide transmembrane transporter activity
F0335_RS21335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F0335_RS21340	COG1137	ATPase activity
F0335_RS21345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F0335_RS21360	COG1660	Displays ATPase and GTPase activities
F0335_RS21365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS21370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0335_RS21370	COG3711	transcriptional antiterminator
F0335_RS21375	COG2706	6-phosphogluconolactonase activity
F0335_RS21390	COG3964	amidohydrolase
F0335_RS21420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0335_RS21430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0335_RS21440	COG2207	Transcriptional regulator
F0335_RS21445	COG3783	Cytochrome b(562)
F0335_RS21450	COG0312	modulator of DNA gyrase
F0335_RS21455	COG3028	Belongs to the UPF0307 family
F0335_RS21460	COG2732	(Barnase) inhibitor
F0335_RS21470	COG1289	transmembrane transporter activity
F0335_RS21475	COG1566	PFAM secretion protein HlyD family protein
F0335_RS21485	COG0583	DNA-binding transcription factor activity
F0335_RS21510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0335_RS21555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0335_RS21570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0335_RS21575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0335_RS21600	COG2134	cdp-diacylglycerol pyrophosphatase
F0335_RS21605	COG0312	modulator of DNA gyrase
F0335_RS21610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0335_RS21615	COG3164	Protein of unknown function
F0335_RS21620	COG1530	ribonuclease E activity
F0335_RS21625	COG0424	maF-like protein
F0335_RS21630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F0335_RS21635	COG1792	Involved in formation and maintenance of cell shape
F0335_RS21640	COG1077	Cell shape determining protein MreB Mrl
F0335_RS21645	COG2200	EAL domain
F0335_RS21645	COG2199	diguanylate cyclase activity
F0335_RS21650	COG0604	alcohol dehydrogenase
F0335_RS21655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F0335_RS21660	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
F0335_RS21665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0335_RS21670	COG0511	ligase activity, forming carbon-carbon bonds
F0335_RS21675	COG0439	Biotin carboxylase
F0335_RS21685	COG0039	L-malate dehydrogenase activity
F0335_RS21695	COG2211	Major facilitator Superfamily
F0335_RS21705	COG3924	membrane
F0335_RS21710	COG4145	pantothenate transmembrane transporter activity
F0335_RS21715	COG2264	protein methyltransferase activity
F0335_RS21740	COG1560	Kdo2-lipid A biosynthetic process
F0335_RS21745	COG0504	CTP synthase activity
F0335_RS21775	COG1380	Effector of murein hydrolase LrgA
F0335_RS21780	COG0583	DNA-binding transcription factor activity
F0335_RS21785	COG0025	NhaP-type Na H and K H
F0335_RS21790	COG2252	PERMEase
F0335_RS21800	COG0625	glutathione transferase activity
F0335_RS21815	COG1028	Short-chain dehydrogenase reductase Sdr
F0335_RS21825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0335_RS21830	COG1064	alcohol dehydrogenase
F0335_RS21835	COG0110	maltose O-acetyltransferase activity
F0335_RS21840	COG2315	Protein conserved in bacteria
F0335_RS21845	COG0432	Pfam Uncharacterised protein family UPF0047
F0335_RS21850	COG1448	Aminotransferase
F0335_RS21855	COG1522	sequence-specific DNA binding
F0335_RS21875	COG0604	alcohol dehydrogenase
F0335_RS21885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0335_RS21895	COG0735	belongs to the Fur family
F0335_RS21900	COG3237	CsbD-like
F0335_RS21905	COG0534	Mate efflux family protein
F0335_RS21910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0335_RS21915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F0335_RS21920	COG2937	Belongs to the GPAT DAPAT family
F0335_RS21925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F0335_RS21930	COG3161	chorismate lyase activity
F0335_RS21935	COG0477	Major facilitator Superfamily
F0335_RS21940	COG1609	Transcriptional regulator
F0335_RS21955	COG4580	involved in the transport of maltose and maltodextrins
F0335_RS21965	COG0366	Alpha amylase catalytic
F0335_RS21970	COG2182	Extracellular solute-binding protein
F0335_RS21975	COG1175	transmembrane transport
F0335_RS21980	COG3833	ABC-type maltose transport systems, permease component
F0335_RS21985	COG3223	Belongs to the PsiE family
F0335_RS21995	COG0166	Belongs to the GPI family
F0335_RS22005	COG0527	aspartate kinase activity
F0335_RS22025	COG1283	sodium-dependent phosphate transmembrane transporter activity
F0335_RS22040	COG0395	ABC-type sugar transport system, permease component
F0335_RS22055	COG2188	Transcriptional regulator
F0335_RS22060	COG1410	methionine synthase
F0335_RS22060	COG0646	methionine synthase
F0335_RS22065	COG1414	Transcriptional regulator
F0335_RS22070	COG3265	gluconokinase activity
F0335_RS22075	COG2610	gluconate transmembrane transporter activity
F0335_RS22080	COG0129	dihydroxy-acid dehydratase activity
F0335_RS22085	COG0800	Aldolase
F0335_RS22090	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
F0335_RS22100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F0335_RS22105	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F0335_RS22145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F0335_RS22150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0335_RS22155	COG0009	L-threonylcarbamoyladenylate synthase
F0335_RS22160	COG0551	DNA topoisomerase type I activity
F0335_RS22165	COG2922	Belongs to the Smg family
F0335_RS22170	COG0758	DNA mediated transformation
F0335_RS22175	COG0242	peptide deformylase activity
F0335_RS22180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0335_RS22185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0335_RS22185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0335_RS22190	COG0569	domain protein
F0335_RS22195	COG1970	mechanosensitive ion channel activity
F0335_RS22200	COG3036	rescue of stalled ribosome
F0335_RS22205	COG0789	Transcriptional regulator
F0335_RS22215	COG0203	ribosomal protein L17
F0335_RS22220	COG0202	RNA polymerase activity
F0335_RS22225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0335_RS22230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0335_RS22235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0335_RS22240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0335_RS22245	COG0201	protein transport
F0335_RS22255	COG1841	ribosomal large subunit assembly
F0335_RS22260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0335_RS22265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0335_RS22270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0335_RS22310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0335_RS22315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0335_RS22325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0335_RS22335	COG0089	rRNA binding
F0335_RS22340	COG0088	Forms part of the polypeptide exit tunnel
F0335_RS22345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0335_RS22350	COG0051	transcription antitermination factor activity, RNA binding
F0335_RS22365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0335_RS22375	COG0049	tRNA binding
F0335_RS22380	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F0335_RS22385	COG2168	tRNA wobble position uridine thiolation
F0335_RS22390	COG2923	Belongs to the DsrF TusC family
F0335_RS22395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F0335_RS22400	COG2964	Protein conserved in bacteria
F0335_RS22405	COG0545	Peptidyl-prolyl cis-trans isomerase
F0335_RS22415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F0335_RS22420	COG1757	Na H antiporter
F0335_RS22425	COG1609	Transcriptional regulator
F0335_RS22430	COG1047	Peptidyl-prolyl cis-trans
F0335_RS22435	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
F0335_RS22445	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0335_RS22450	COG0488	(ABC) transporter
F0335_RS22455	COG2175	clavaminate synthase activity
F0335_RS22460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F0335_RS22470	COG4521	taurine ABC transporter
F0335_RS22485	COG0429	hydrolase of the alpha beta-hydrolase fold
F0335_RS22490	COG3089	Belongs to the UPF0270 family
F0335_RS22495	COG3954	Phosphoribulokinase
F0335_RS22500	COG1765	OsmC-like protein
F0335_RS22505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0335_RS22510	COG1289	transmembrane transporter activity
F0335_RS22525	COG0433	COG0433 Predicted ATPase
F0335_RS22535	COG3275	phosphorelay sensor kinase activity
F0335_RS22540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0335_RS22545	COG1447	Phosphotransferase system cellobiose-specific component IIA
F0335_RS22550	COG1486	melibiose metabolic process
F0335_RS22555	COG1609	Transcriptional regulator
F0335_RS22560	COG0738	Major facilitator superfamily
F0335_RS22565	COG0402	S-adenosylhomocysteine deaminase activity
F0335_RS22570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0335_RS22580	COG2116	formate transmembrane transporter activity
F0335_RS22585	COG1648	precorrin-2 dehydrogenase activity
F0335_RS22585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0335_RS22590	COG0180	Tryptophanyl-tRNA synthetase
F0335_RS22595	COG0546	phosphoglycolate phosphatase activity
F0335_RS22615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F0335_RS22620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0335_RS22625	COG4796	Type ii and iii secretion system protein
F0335_RS22650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F0335_RS22655	COG0494	nUDIX hydrolase
F0335_RS22665	COG1011	Hydrolase
F0335_RS22670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F0335_RS22675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F0335_RS22700	COG0745	RESPONSE REGULATOR receiver
F0335_RS22710	COG0484	heat shock protein binding
F0335_RS22715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0335_RS22725	COG1918	ferrous iron import across plasma membrane
F0335_RS22750	COG1040	competence protein
F0335_RS22755	COG0316	Belongs to the HesB IscA family
F0335_RS22755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F0335_RS22765	COG0058	SHG alpha-glucan phosphorylase activity
F0335_RS22770	COG2909	trisaccharide binding
F0335_RS22775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0335_RS22780	COG0705	Rhomboid family
F0335_RS22785	COG1349	DNA-binding transcription factor activity
F0335_RS22790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0335_RS22795	COG0058	SHG alpha-glucan phosphorylase activity
F0335_RS22800	COG0297	glycogen (starch) synthase activity
F0335_RS22805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0335_RS22810	COG1523	belongs to the glycosyl hydrolase 13 family
F0335_RS22815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F0335_RS22820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0335_RS22825	COG2095	MarC family integral membrane protein
F0335_RS22830	COG3265	gluconokinase activity
F0335_RS22835	COG2610	gluconate transmembrane transporter activity
F0335_RS22840	COG1609	Transcriptional regulator
F0335_RS22845	COG1741	Belongs to the pirin family
F0335_RS22850	COG1247	-acetyltransferase
F0335_RS22855	COG3191	aminopeptidase activity
F0335_RS22860	COG1082	Xylose isomerase domain protein TIM barrel
F0335_RS22865	COG1082	Xylose isomerase domain protein TIM barrel
F0335_RS22870	COG0673	inositol 2-dehydrogenase activity
F0335_RS22875	COG3962	Belongs to the TPP enzyme family
F0335_RS22880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0335_RS22900	COG3718	enzyme involved in inositol metabolism
F0335_RS22910	COG2814	Major facilitator Superfamily
F0335_RS22910	COG0477	Major facilitator Superfamily
F0335_RS22925	COG4619	ABC transporter
F0335_RS22950	COG3188	usher protein
F0335_RS22975	COG2197	response regulator
F0335_RS22985	COG0697	spore germination
F0335_RS23015	COG1957	nucleoside hydrolase
F0335_RS23025	COG2081	HI0933 family
F0335_RS23030	COG0306	phosphate transporter
F0335_RS23050	COG0475	glutathione-regulated potassium exporter activity
F0335_RS23050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0335_RS23060	COG0583	DNA-binding transcription factor activity
F0335_RS23065	COG0589	response to stress
F0335_RS23080	COG1129	ABC transporter
F0335_RS23085	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS23090	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS23105	COG0742	ribosomal rna small subunit methyltransferase
F0335_RS23110	COG0339	signal peptide processing
F0335_RS23135	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F0335_RS23140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0335_RS23145	COG2318	DinB family
F0335_RS23160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0335_RS23170	COG2205	protein histidine kinase activity
F0335_RS23170	COG0784	Response regulator, receiver
F0335_RS23195	COG5441	Belongs to the UPF0261 family
F0335_RS23200	COG3678	ATP-independent chaperone mediated protein folding
F0335_RS23205	COG5001	Diguanylate cyclase
F0335_RS23210	COG1024	Enoyl-CoA hydratase
F0335_RS23215	COG1295	ribonuclease BN
F0335_RS23220	COG0477	Major facilitator Superfamily
F0335_RS23225	COG2134	cdp-diacylglycerol pyrophosphatase
F0335_RS23230	COG2982	Protein involved in outer membrane biogenesis
F0335_RS23235	COG2200	EAL domain
F0335_RS23240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0335_RS23245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0335_RS23275	COG0129	dihydroxy-acid dehydratase activity
F0335_RS23280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0335_RS23285	COG3978	acetolactate synthase activity
F0335_RS23300	COG2814	Major facilitator Superfamily
F0335_RS23310	COG3085	chromosome segregation
F0335_RS23315	COG0583	DNA-binding transcription factor activity
F0335_RS23350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0335_RS23355	COG4206	TonB-dependent receptor
F0335_RS23360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0335_RS23375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0335_RS23385	COG0678	peroxiredoxin activity
F0335_RS23385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0335_RS23390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0335_RS23400	COG0165	Argininosuccinate lyase
F0335_RS23405	COG0137	argininosuccinate synthase activity
F0335_RS23410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0335_RS23425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F0335_RS23430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F0335_RS23435	COG0460	homoserine dehydrogenase
F0335_RS23435	COG0527	aspartate kinase activity
F0335_RS23440	COG0626	cystathionine gamma-synthase activity
F0335_RS23445	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F0335_RS23450	COG0254	rRNA binding
F0335_RS23455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F0335_RS23465	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0335_RS23470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F0335_RS23475	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F0335_RS23480	COG1575	Belongs to the MenA family. Type 1 subfamily
F0335_RS23485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F0335_RS23490	COG3074	FtsZ-dependent cytokinesis
F0335_RS23505	COG1494	fructose-1,6-bisphosphatase
F0335_RS23510	COG1275	C4-dicarboxylate transporter malic acid transport protein
F0335_RS23515	COG2814	Major facilitator Superfamily
F0335_RS23530	COG3152	Membrane
F0335_RS23540	COG0149	triose-phosphate isomerase activity
F0335_RS23545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F0335_RS23550	COG0205	6-phosphofructokinase activity
F0335_RS23555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F0335_RS23560	COG3678	ATP-independent chaperone mediated protein folding
F0335_RS23565	COG0745	RESPONSE REGULATOR receiver
F0335_RS23570	COG2205	protein histidine kinase activity
F0335_RS23575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F0335_RS23590	COG1045	serine acetyltransferase
F0335_RS23605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0335_RS23610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0335_RS23615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F0335_RS23620	COG4942	peptidase
F0335_RS23625	COG2861	carbohydrate metabolic process
F0335_RS23630	COG1063	alcohol dehydrogenase
F0335_RS23635	COG0156	8-amino-7-oxononanoate synthase activity
F0335_RS23640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0335_RS23645	COG0859	PFAM glycosyl transferase family 9
F0335_RS23650	COG0859	PFAM glycosyl transferase family 9
F0335_RS23655	COG0438	transferase activity, transferring glycosyl groups
F0335_RS23660	COG3307	-O-antigen
F0335_RS23665	COG1442	glycosyl transferase family 8
F0335_RS23665	COG1216	Glycosyl transferase, family 2
F0335_RS23680	COG0859	PFAM glycosyl transferase family 9
F0335_RS23685	COG0438	transferase activity, transferring glycosyl groups
F0335_RS23690	COG0438	transferase activity, transferring glycosyl groups
F0335_RS23700	COG1519	Transferase
F0335_RS23720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0335_RS23725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0335_RS23730	COG2003	Belongs to the UPF0758 family
F0335_RS23735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F0335_RS23740	COG0756	dUTP diphosphatase activity
F0335_RS23745	COG1309	transcriptional regulator
F0335_RS23750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0335_RS23755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F0335_RS23760	COG1561	YicC-like family, N-terminal region
F0335_RS23845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0335_RS23855	COG2860	membrane
F0335_RS23860	COG0583	DNA-binding transcription factor activity
F0335_RS23870	COG0194	GDP metabolic process
F0335_RS23875	COG1758	RNA polymerase activity
F0335_RS23880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0335_RS23885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0335_RS23890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0335_RS23895	COG0786	glutamate:sodium symporter activity
F0335_RS23900	COG2233	PERMEase
F0335_RS23905	COG2982	Protein involved in outer membrane biogenesis
F0335_RS23910	COG0456	acetyltransferase
F0335_RS23915	COG1490	D-aminoacyl-tRNA deacylase activity
F0335_RS23920	COG1295	ribonuclease BN
F0335_RS23925	COG1011	Hydrolase
F0335_RS23935	COG0174	glutamine synthetase
F0335_RS23940	COG3852	Histidine kinase
F0335_RS23955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0335_RS23960	COG3078	GTPase activator activity
F0335_RS23965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F0335_RS23970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0335_RS23970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0335_RS23975	COG0204	Acyl-transferase
F0335_RS23980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0335_RS23985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F0335_RS23990	COG3084	Protein conserved in bacteria
F0335_RS23995	COG0746	molybdenum cofactor guanylyltransferase activity
F0335_RS24000	COG1763	Mo-molybdopterin cofactor biosynthetic process
F0335_RS24025	COG2186	Transcriptional regulator
F0335_RS24030	COG0477	Major facilitator Superfamily
F0335_RS24035	COG1609	Transcriptional regulator
F0335_RS24040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0335_RS24050	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0335_RS24055	COG1129	ABC transporter
F0335_RS24060	COG1869	D-ribose catabolic process
F0335_RS24065	COG3158	transport of potassium into the cell
F0335_RS24070	COG0714	Associated with various cellular activities
F0335_RS24075	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F0335_RS24080	COG2502	aspartate--ammonia ligase
F0335_RS24085	COG1522	sequence-specific DNA binding
F0335_RS24090	COG0716	FMN binding
F0335_RS24095	COG0445	tRNA wobble uridine modification
F0335_RS24100	COG0357	Ribosomal RNA small subunit methyltransferase G
F0335_RS24105	COG3312	ion transport
F0335_RS24120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0335_RS24125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0335_RS24130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0335_RS24135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0335_RS24140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0335_RS24145	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0335_RS24150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F0335_RS24160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0335_RS24165	COG0573	inorganic phosphate transmembrane transporter activity
F0335_RS24170	COG0581	inorganic phosphate transmembrane transporter activity
F0335_RS24185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0335_RS24190	COG0765	amino acid transport
F0335_RS24195	COG0765	amino acid transport
F0335_RS24200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0335_RS24210	COG2252	PERMEase
F0335_RS24220	COG0431	NADPH-dependent FMN reductase
F0335_RS24225	COG2091	lysine biosynthetic process via aminoadipic acid
F0335_RS24235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0335_RS24240	COG0706	membrane insertase activity
F0335_RS24245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F0335_RS24250	COG0594	ribonuclease P activity