locus-tag	class	description
SMWW4_RS00005	COG3312	ion transport
SMWW4_RS00020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMWW4_RS00025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMWW4_RS00030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMWW4_RS00035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMWW4_RS00040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMWW4_RS00045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMWW4_RS00050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMWW4_RS00060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMWW4_RS00065	COG0573	inorganic phosphate transmembrane transporter activity
SMWW4_RS00070	COG0581	inorganic phosphate transmembrane transporter activity
SMWW4_RS00080	COG0704	Plays a role in the regulation of phosphate uptake
SMWW4_RS00085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS00090	COG0765	amino acid transport
SMWW4_RS00095	COG0765	amino acid transport
SMWW4_RS00100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMWW4_RS00105	COG0494	nUDIX hydrolase
SMWW4_RS00110	COG2252	PERMEase
SMWW4_RS00120	COG0431	NADPH-dependent FMN reductase
SMWW4_RS00125	COG2091	lysine biosynthetic process via aminoadipic acid
SMWW4_RS00145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMWW4_RS00150	COG0706	membrane insertase activity
SMWW4_RS00155	COG0594	ribonuclease P activity
SMWW4_RS00165	COG0592	DNA-directed DNA polymerase activity
SMWW4_RS00170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMWW4_RS00175	COG0187	DNA topoisomerase II activity
SMWW4_RS00180	COG0561	phosphatase activity
SMWW4_RS00190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMWW4_RS00200	COG0823	Involved in the tonB-independent uptake of proteins
SMWW4_RS00205	COG5645	(Lipo)protein
SMWW4_RS00215	COG0071	Belongs to the small heat shock protein (HSP20) family
SMWW4_RS00220	COG0071	Belongs to the small heat shock protein (HSP20) family
SMWW4_RS00225	COG2985	domain, Protein
SMWW4_RS00230	COG3977	Valine--pyruvate aminotransferase
SMWW4_RS00235	COG0366	Alpha amylase catalytic
SMWW4_RS00240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMWW4_RS00245	COG2814	Major facilitator Superfamily
SMWW4_RS00250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMWW4_RS00260	COG1609	Transcriptional regulator
SMWW4_RS00265	COG2885	chlorophyll binding
SMWW4_RS00275	COG2818	Glycosylase
SMWW4_RS00285	COG0752	glycyl-tRNA synthetase alpha subunit
SMWW4_RS00290	COG0751	glycine-tRNA ligase activity
SMWW4_RS00300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMWW4_RS00300	COG2213	PTS system mannitol-specific
SMWW4_RS00305	COG0246	Mannitol dehydrogenase
SMWW4_RS00310	COG3722	fumarate hydratase activity
SMWW4_RS00320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMWW4_RS00335	COG2258	MOSC domain
SMWW4_RS00345	COG0840	transmembrane signaling receptor activity
SMWW4_RS00350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMWW4_RS00355	COG3383	formate dehydrogenase (NAD+) activity
SMWW4_RS00355	COG0243	molybdopterin cofactor binding
SMWW4_RS00360	COG3383	formate dehydrogenase (NAD+) activity
SMWW4_RS00360	COG0243	molybdopterin cofactor binding
SMWW4_RS00365	COG0437	4 iron, 4 sulfur cluster binding
SMWW4_RS00370	COG2864	formate dehydrogenase
SMWW4_RS00375	COG3058	Necessary for formate dehydrogenase activity
SMWW4_RS00385	COG0625	glutathione transferase activity
SMWW4_RS00390	COG1921	L-seryl-tRNASec selenium transferase activity
SMWW4_RS00395	COG3276	selenocysteine insertion sequence binding
SMWW4_RS00415	COG3274	enterobacterial common antigen metabolic process
SMWW4_RS00425	COG1335	isochorismatase
SMWW4_RS00430	COG0402	S-adenosylhomocysteine deaminase activity
SMWW4_RS00445	COG0583	DNA-binding transcription factor activity
SMWW4_RS00450	COG2807	transmembrane transport
SMWW4_RS00460	COG0582	viral genome integration into host DNA
SMWW4_RS00545	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS00560	COG3188	usher protein
SMWW4_RS00565	COG3121	Chaperone
SMWW4_RS00575	COG3539	Fimbrial protein
SMWW4_RS00580	COG3539	Fimbrial protein
SMWW4_RS00585	COG3539	Fimbrial protein
SMWW4_RS00645	COG1902	pentaerythritol trinitrate reductase activity
SMWW4_RS00650	COG2814	Major facilitator Superfamily
SMWW4_RS00680	COG1846	Transcriptional regulator
SMWW4_RS00685	COG1764	response to oxidative stress
SMWW4_RS00690	COG2194	sulfuric ester hydrolase activity
SMWW4_RS00695	COG2197	response regulator
SMWW4_RS00705	COG2271	Major facilitator Superfamily
SMWW4_RS00730	COG0747	negative chemotaxis
SMWW4_RS00735	COG0601	transmembrane transport
SMWW4_RS00740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMWW4_RS00745	COG0444	Belongs to the ABC transporter superfamily
SMWW4_RS00750	COG4608	Belongs to the ABC transporter superfamily
SMWW4_RS00755	COG2194	sulfuric ester hydrolase activity
SMWW4_RS00780	COG1215	transferase activity, transferring glycosyl groups
SMWW4_RS00785	COG1215	transferase activity, transferring glycosyl groups
SMWW4_RS00790	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SMWW4_RS00795	COG3118	belongs to the thioredoxin family
SMWW4_RS00795	COG0457	Tetratricopeptide repeat
SMWW4_RS00800	COG2200	EAL domain
SMWW4_RS00800	COG2199	diguanylate cyclase activity
SMWW4_RS00805	COG1301	dicarboxylic acid transport
SMWW4_RS00810	COG0612	Peptidase, M16
SMWW4_RS00815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMWW4_RS00825	COG0248	Ppx GppA phosphatase
SMWW4_RS00835	COG3118	belongs to the thioredoxin family
SMWW4_RS00840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMWW4_RS00845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMWW4_RS00855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMWW4_RS00860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SMWW4_RS00865	COG1088	dTDP-glucose 4,6-dehydratase activity
SMWW4_RS00870	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMWW4_RS00875	COG0456	acetyltransferase
SMWW4_RS00880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMWW4_RS00885	COG2244	polysaccharide biosynthetic process
SMWW4_RS00890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMWW4_RS00900	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SMWW4_RS00930	COG3071	HemY protein
SMWW4_RS00935	COG2959	enzyme of heme biosynthesis
SMWW4_RS00945	COG0181	hydroxymethylbilane synthase activity
SMWW4_RS00950	COG3072	Adenylate cyclase
SMWW4_RS00955	COG1965	Belongs to the frataxin family
SMWW4_RS00960	COG5567	small periplasmic lipoprotein
SMWW4_RS00965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMWW4_RS00970	COG3159	Protein conserved in bacteria
SMWW4_RS00980	COG1011	Hydrolase
SMWW4_RS00985	COG0210	DNA helicase
SMWW4_RS01005	COG2050	protein possibly involved in aromatic compounds catabolism
SMWW4_RS01015	COG0514	ATP-dependent DNA helicase (RecQ)
SMWW4_RS01020	COG1280	lysine exporter protein (LysE YggA)
SMWW4_RS01025	COG1280	lysine exporter protein (LysE YggA)
SMWW4_RS01030	COG2267	carboxylic ester hydrolase activity
SMWW4_RS01035	COG0561	phosphatase activity
SMWW4_RS01040	COG0584	glycerophosphoryl diester phosphodiesterase
SMWW4_RS01045	COG2271	Major facilitator Superfamily
SMWW4_RS01050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMWW4_RS01060	COG0247	lactate metabolic process
SMWW4_RS01075	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SMWW4_RS01080	COG0425	Belongs to the sulfur carrier protein TusA family
SMWW4_RS01085	COG2217	Heavy metal translocating P-type atpase
SMWW4_RS01100	COG3714	YhhN family
SMWW4_RS01110	COG3776	membrane
SMWW4_RS01115	COG0742	ribosomal rna small subunit methyltransferase
SMWW4_RS01120	COG0552	protein localization to endoplasmic reticulum
SMWW4_RS01125	COG2884	Cell division ATP-binding protein ftsE
SMWW4_RS01130	COG2177	Part of the ABC transporter FtsEX involved in
SMWW4_RS01150	COG0456	acetyltransferase
SMWW4_RS01160	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS01165	COG4177	L-phenylalanine transmembrane transporter activity
SMWW4_RS01180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMWW4_RS01185	COG1653	transport
SMWW4_RS01190	COG1175	transmembrane transport
SMWW4_RS01200	COG3842	ATPase activity
SMWW4_RS01205	COG0584	glycerophosphoryl diester phosphodiesterase
SMWW4_RS01220	COG0697	spore germination
SMWW4_RS01230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMWW4_RS01235	COG0412	Dienelactone hydrolase
SMWW4_RS01250	COG0586	Pfam SNARE associated Golgi protein
SMWW4_RS01255	COG1322	Protein conserved in bacteria
SMWW4_RS01260	COG2226	methyltransferase
SMWW4_RS01265	COG3165	ubiquinone biosynthetic process from chorismate
SMWW4_RS01270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMWW4_RS01275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMWW4_RS01285	COG0805	protein transport
SMWW4_RS01290	COG0084	hydrolase, TatD family'
SMWW4_RS01320	COG0183	Belongs to the thiolase family
SMWW4_RS01325	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMWW4_RS01325	COG1024	Enoyl-CoA hydratase
SMWW4_RS01335	COG0006	proline dipeptidase activity
SMWW4_RS01340	COG1739	Uncharacterized protein family UPF0029
SMWW4_RS01345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMWW4_RS01375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMWW4_RS01380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SMWW4_RS01380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SMWW4_RS01385	COG1072	(Pantothenic acid kinase))
SMWW4_RS01415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMWW4_RS01425	COG0250	Participates in transcription elongation, termination and antitermination
SMWW4_RS01440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMWW4_RS01450	COG0085	RNA polymerase activity
SMWW4_RS01455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMWW4_RS01485	COG2022	thiamine diphosphate biosynthetic process
SMWW4_RS01490	COG2104	thiamine diphosphate biosynthetic process
SMWW4_RS01495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMWW4_RS01500	COG0352	thiamine-phosphate diphosphorylase activity
SMWW4_RS01510	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
SMWW4_RS01515	COG2816	NAD+ diphosphatase activity
SMWW4_RS01520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMWW4_RS01525	COG1515	deoxyribonuclease V activity
SMWW4_RS01545	COG0151	Belongs to the GarS family
SMWW4_RS01550	COG0138	bifunctional purine biosynthesis protein purh
SMWW4_RS01580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMWW4_RS01585	COG3162	membrane
SMWW4_RS01590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMWW4_RS01595	COG1301	dicarboxylic acid transport
SMWW4_RS01600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMWW4_RS01600	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SMWW4_RS01605	COG3433	isochorismatase activity
SMWW4_RS01605	COG2226	methyltransferase
SMWW4_RS01605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMWW4_RS01610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMWW4_RS01615	COG1629	transport
SMWW4_RS01615	COG4774	siderophore transport
SMWW4_RS01620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMWW4_RS01625	COG3391	amine dehydrogenase activity
SMWW4_RS01630	COG4771	TonB-dependent receptor
SMWW4_RS01635	COG2382	esterase
SMWW4_RS01645	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SMWW4_RS01645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMWW4_RS01655	COG1169	isochorismate synthase
SMWW4_RS01660	COG1021	2,3-dihydroxybenzoate-AMP ligase
SMWW4_RS01665	COG3433	isochorismatase activity
SMWW4_RS01665	COG1535	isochorismatase
SMWW4_RS01675	COG3647	Membrane
SMWW4_RS01680	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS01705	COG3188	usher protein
SMWW4_RS01710	COG3121	Chaperone
SMWW4_RS01745	COG0583	DNA-binding transcription factor activity
SMWW4_RS01750	COG2814	Major facilitator Superfamily
SMWW4_RS01775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMWW4_RS01790	COG1309	transcriptional regulator
SMWW4_RS01795	COG4232	protein-disulfide reductase activity
SMWW4_RS01805	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMWW4_RS01820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMWW4_RS01830	COG0840	transmembrane signaling receptor activity
SMWW4_RS01840	COG1509	lysine 2,3-aminomutase activity
SMWW4_RS01845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMWW4_RS01850	COG5510	response to toxic substance
SMWW4_RS01855	COG5510	response to toxic substance
SMWW4_RS01865	COG3040	lipid binding
SMWW4_RS01870	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
SMWW4_RS01875	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
SMWW4_RS01880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMWW4_RS01885	COG1053	succinate dehydrogenase
SMWW4_RS01890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SMWW4_RS01895	COG3264	Mechanosensitive ion channel
SMWW4_RS01895	COG1511	domain protein
SMWW4_RS01905	COG1162	GTPase activity
SMWW4_RS01910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SMWW4_RS01930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMWW4_RS01935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMWW4_RS01935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMWW4_RS01940	COG0802	atpase or kinase
SMWW4_RS01950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMWW4_RS01955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMWW4_RS01965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMWW4_RS01970	COG0330	HflC and HflK could
SMWW4_RS01975	COG0330	HflC and HflK could
SMWW4_RS01980	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
SMWW4_RS01985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMWW4_RS01990	COG1959	2 iron, 2 sulfur cluster binding
SMWW4_RS01995	COG0557	exoribonuclease II activity
SMWW4_RS02000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMWW4_RS02005	COG1960	acyl-CoA dehydrogenase activity
SMWW4_RS02010	COG3766	membrane
SMWW4_RS02020	COG3650	response to hydrogen peroxide
SMWW4_RS02025	COG1073	alpha beta
SMWW4_RS02040	COG0360	Binds together with S18 to 16S ribosomal RNA
SMWW4_RS02045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMWW4_RS02050	COG0359	binds to the 23S rRNA
SMWW4_RS02060	COG3061	Opacity-associated protein A
SMWW4_RS02065	COG0545	Peptidyl-prolyl cis-trans isomerase
SMWW4_RS02070	COG0737	Belongs to the 5'-nucleotidase family
SMWW4_RS02080	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
SMWW4_RS02090	COG1253	flavin adenine dinucleotide binding
SMWW4_RS02095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMWW4_RS02100	COG0729	surface antigen
SMWW4_RS02105	COG2911	Protein conserved in bacteria
SMWW4_RS02110	COG2105	PFAM AIG2 family protein
SMWW4_RS02115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMWW4_RS02120	COG0840	transmembrane signaling receptor activity
SMWW4_RS02125	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMWW4_RS02130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMWW4_RS02145	COG1438	arginine binding
SMWW4_RS02150	COG0039	L-malate dehydrogenase activity
SMWW4_RS02155	COG3423	Transcriptional regulator
SMWW4_RS02165	COG0142	geranyltranstransferase activity
SMWW4_RS02170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMWW4_RS02175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMWW4_RS02180	COG0697	spore germination
SMWW4_RS02185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMWW4_RS02190	COG0642	Histidine kinase
SMWW4_RS02195	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS02200	COG2027	D-alanyl-D-alanine carboxypeptidase
SMWW4_RS02210	COG1534	Rna-binding protein
SMWW4_RS02215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SMWW4_RS02225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMWW4_RS02230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMWW4_RS02235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMWW4_RS02250	COG0779	Required for maturation of 30S ribosomal subunits
SMWW4_RS02255	COG0195	Participates in both transcription termination and antitermination
SMWW4_RS02260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMWW4_RS02265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMWW4_RS02270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMWW4_RS02275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMWW4_RS02280	COG1185	polyribonucleotide nucleotidyltransferase activity
SMWW4_RS02290	COG0513	Belongs to the DEAD box helicase family
SMWW4_RS02295	COG2391	methyltransferase activity
SMWW4_RS02300	COG0425	Belongs to the sulfur carrier protein TusA family
SMWW4_RS02305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMWW4_RS02325	COG0826	peptidase U32
SMWW4_RS02330	COG0826	peptidase U32
SMWW4_RS02335	COG3154	lipid carrier protein
SMWW4_RS02340	COG3153	acetyltransferase
SMWW4_RS02345	COG2827	Endonuclease containing a URI domain
SMWW4_RS02355	COG0531	amino acid
SMWW4_RS02360	COG1982	Orn Lys Arg decarboxylase major
SMWW4_RS02365	COG3787	Belongs to the UPF0306 family
SMWW4_RS02370	COG0702	epimerase
SMWW4_RS02375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMWW4_RS02385	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SMWW4_RS02390	COG3454	Phosphonate metabolism
SMWW4_RS02395	COG4778	phosphonate C-P lyase system protein PhnL
SMWW4_RS02400	COG4107	phosphonate C-P lyase system protein PhnK
SMWW4_RS02405	COG3627	carbon phosphorus lyase activity
SMWW4_RS02410	COG3626	phosphonate metabolism
SMWW4_RS02415	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
SMWW4_RS02420	COG3624	Phosphonate C-P lyase system protein PhnG
SMWW4_RS02425	COG2188	Transcriptional regulator
SMWW4_RS02430	COG0701	Predicted permease
SMWW4_RS02440	COG0602	queuosine metabolic process
SMWW4_RS02450	COG0583	DNA-binding transcription factor activity
SMWW4_RS02455	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMWW4_RS02460	COG0366	Alpha amylase catalytic
SMWW4_RS02465	COG1263	PTS System
SMWW4_RS02465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS02475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMWW4_RS02480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMWW4_RS02500	COG2308	Evidence 4 Homologs of previously reported genes of
SMWW4_RS02515	COG0540	Belongs to the ATCase OTCase family
SMWW4_RS02525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMWW4_RS02540	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMWW4_RS02545	COG0456	acetyltransferase
SMWW4_RS02555	COG2927	DNA polymerase III (CHI subunit)
SMWW4_RS02560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMWW4_RS02565	COG0795	lipopolysaccharide-transporting ATPase activity
SMWW4_RS02570	COG0795	lipopolysaccharide-transporting ATPase activity
SMWW4_RS02600	COG0556	nucleotide-excision repair
SMWW4_RS02615	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SMWW4_RS02620	COG1715	Restriction endonuclease
SMWW4_RS02645	COG2723	6-phospho-beta-galactosidase activity
SMWW4_RS02650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS02650	COG1263	PTS System
SMWW4_RS02655	COG1609	Transcriptional regulator
SMWW4_RS02660	COG1088	dTDP-glucose 4,6-dehydratase activity
SMWW4_RS02670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMWW4_RS02675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMWW4_RS02685	COG0523	cobalamin synthesis protein
SMWW4_RS02690	COG2879	small protein
SMWW4_RS02695	COG1966	Carbon starvation protein
SMWW4_RS02705	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SMWW4_RS02715	COG0174	glutamine synthetase
SMWW4_RS02745	COG0583	DNA-binding transcription factor activity
SMWW4_RS02750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SMWW4_RS02765	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMWW4_RS02770	COG2610	gluconate transmembrane transporter activity
SMWW4_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS02785	COG2207	Transcriptional regulator
SMWW4_RS02795	COG3708	Transcriptional regulator
SMWW4_RS02795	COG2207	Transcriptional regulator
SMWW4_RS02800	COG1376	ErfK ybiS ycfS ynhG family protein
SMWW4_RS02805	COG1846	Transcriptional regulator
SMWW4_RS02810	COG0163	prenyltransferase activity
SMWW4_RS02815	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMWW4_RS02820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SMWW4_RS02845	COG0811	peptide transport
SMWW4_RS02880	COG1454	alcohol dehydrogenase
SMWW4_RS02890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMWW4_RS02900	COG2267	carboxylic ester hydrolase activity
SMWW4_RS02930	COG1113	amino acid transport
SMWW4_RS02950	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS02980	COG1846	Transcriptional regulator
SMWW4_RS02995	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS03000	COG3384	dioxygenase
SMWW4_RS03010	COG3971	2-oxopent-4-enoate hydratase activity
SMWW4_RS03030	COG2368	4-hydroxyphenylacetate
SMWW4_RS03035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMWW4_RS03040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMWW4_RS03050	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS03055	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMWW4_RS03060	COG4948	Mandelate Racemase Muconate Lactonizing
SMWW4_RS03065	COG3618	amidohydrolase
SMWW4_RS03070	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS03075	COG3254	rhamnose metabolic process
SMWW4_RS03080	COG0738	Major facilitator superfamily
SMWW4_RS03100	COG1309	transcriptional regulator
SMWW4_RS03105	COG3706	GGDEF domain
SMWW4_RS03135	COG0667	Aldo Keto reductase
SMWW4_RS03140	COG0582	viral genome integration into host DNA
SMWW4_RS03175	COG0582	viral genome integration into host DNA
SMWW4_RS03210	COG0545	Peptidyl-prolyl cis-trans isomerase
SMWW4_RS03285	COG2813	Specifically methylates the guanine in position
SMWW4_RS03290	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
SMWW4_RS03305	COG3550	peptidyl-serine autophosphorylation
SMWW4_RS03310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMWW4_RS03315	COG2823	Periplasmic or secreted lipoprotein
SMWW4_RS03320	COG3237	CsbD-like
SMWW4_RS03325	COG4667	esterase of the alpha-beta hydrolase superfamily
SMWW4_RS03330	COG0084	hydrolase, TatD family'
SMWW4_RS03335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SMWW4_RS03340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMWW4_RS03350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SMWW4_RS03355	COG0813	purine-nucleoside phosphorylase activity
SMWW4_RS03360	COG3726	membrane protein affecting hemolysin expression
SMWW4_RS03365	COG0560	Phosphoserine phosphatase
SMWW4_RS03385	COG0604	alcohol dehydrogenase
SMWW4_RS03395	COG0488	(ABC) transporter
SMWW4_RS03400	COG2885	chlorophyll binding
SMWW4_RS03405	COG2199	diguanylate cyclase activity
SMWW4_RS03415	COG0741	lytic transglycosylase activity
SMWW4_RS03420	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
SMWW4_RS03425	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
SMWW4_RS03430	COG0406	alpha-ribazole phosphatase activity
SMWW4_RS03435	COG3708	Transcriptional regulator
SMWW4_RS03435	COG2207	Transcriptional regulator
SMWW4_RS03440	COG3045	CreA protein
SMWW4_RS03445	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS03470	COG3022	response to hydroperoxide
SMWW4_RS03475	COG1115	amino acid carrier protein
SMWW4_RS03480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMWW4_RS03485	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMWW4_RS03495	COG1584	GPR1 FUN34 yaaH family protein
SMWW4_RS03500	COG0443	Heat shock 70 kDa protein
SMWW4_RS03505	COG0484	heat shock protein binding
SMWW4_RS03510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMWW4_RS03515	COG0583	DNA-binding transcription factor activity
SMWW4_RS03520	COG0268	Binds directly to 16S ribosomal RNA
SMWW4_RS03525	COG0196	riboflavin kinase activity
SMWW4_RS03530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMWW4_RS03535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMWW4_RS03540	COG1047	Peptidyl-prolyl cis-trans
SMWW4_RS03545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMWW4_RS03570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMWW4_RS03575	COG0505	Belongs to the CarA family
SMWW4_RS03580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMWW4_RS03585	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMWW4_RS03600	COG2966	Psort location CytoplasmicMembrane, score
SMWW4_RS03610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMWW4_RS03620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMWW4_RS03625	COG2967	ApaG domain
SMWW4_RS03630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMWW4_RS03635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMWW4_RS03645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SMWW4_RS03655	COG0564	pseudouridine synthase activity
SMWW4_RS03660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMWW4_RS03665	COG0417	DNA replication proofreading
SMWW4_RS03670	COG0586	Pfam SNARE associated Golgi protein
SMWW4_RS03675	COG0440	acetolactate synthase activity
SMWW4_RS03680	COG0028	Belongs to the TPP enzyme family
SMWW4_RS03690	COG1178	ABC-type Fe3 transport system permease component
SMWW4_RS03705	COG2814	Major facilitator Superfamily
SMWW4_RS03710	COG0471	metal ion transport
SMWW4_RS03715	COG0066	3-isopropylmalate dehydratase activity
SMWW4_RS03720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMWW4_RS03725	COG0473	3-isopropylmalate dehydrogenase activity
SMWW4_RS03730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMWW4_RS03735	COG0583	DNA-binding transcription factor activity
SMWW4_RS03740	COG1022	Amp-dependent synthetase and ligase
SMWW4_RS03745	COG0028	Belongs to the TPP enzyme family
SMWW4_RS03765	COG2001	Belongs to the MraZ family
SMWW4_RS03770	COG0275	rRNA processing
SMWW4_RS03775	COG3116	cell division
SMWW4_RS03780	COG0768	penicillin binding
SMWW4_RS03785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMWW4_RS03790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMWW4_RS03795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMWW4_RS03805	COG0772	Belongs to the SEDS family
SMWW4_RS03810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMWW4_RS03815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMWW4_RS03825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SMWW4_RS03830	COG0849	cell division
SMWW4_RS03835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMWW4_RS03855	COG0653	protein targeting
SMWW4_RS03860	COG0494	nUDIX hydrolase
SMWW4_RS03865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SMWW4_RS03870	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
SMWW4_RS03880	COG0516	GMP reductase activity
SMWW4_RS03885	COG1459	type II secretion system
SMWW4_RS03890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMWW4_RS03895	COG4969	Belongs to the N-Me-Phe pilin family
SMWW4_RS03905	COG3023	N-Acetylmuramoyl-L-alanine amidase
SMWW4_RS03910	COG3725	Membrane protein required for beta-lactamase induction
SMWW4_RS03915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMWW4_RS03925	COG0316	Belongs to the HesB IscA family
SMWW4_RS03930	COG2860	membrane
SMWW4_RS03940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMWW4_RS03945	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMWW4_RS03950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMWW4_RS03960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMWW4_RS03965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMWW4_RS03970	COG3956	TIGRFAM MazG family protein
SMWW4_RS03980	COG0504	CTP synthase activity
SMWW4_RS04010	COG2986	histidine ammonia-lyase
SMWW4_RS04020	COG2271	Major facilitator Superfamily
SMWW4_RS04025	COG0602	queuosine metabolic process
SMWW4_RS04030	COG0720	synthase
SMWW4_RS04035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SMWW4_RS04040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMWW4_RS04045	COG0175	sulfate reduction
SMWW4_RS04050	COG2234	aminopeptidase activity
SMWW4_RS04055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMWW4_RS04055	COG1648	precorrin-2 dehydrogenase activity
SMWW4_RS04060	COG0175	sulfate reduction
SMWW4_RS04065	COG2895	sulfate adenylyltransferase (ATP) activity
SMWW4_RS04080	COG1126	abc transporter atp-binding protein
SMWW4_RS04085	COG0765	amino acid transport
SMWW4_RS04095	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SMWW4_RS04100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMWW4_RS04105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMWW4_RS04110	COG0585	pseudouridine synthase activity
SMWW4_RS04115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMWW4_RS04120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMWW4_RS04125	COG1388	LysM domain
SMWW4_RS04125	COG4942	peptidase
SMWW4_RS04130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMWW4_RS04135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SMWW4_RS04145	COG0667	Aldo Keto reductase
SMWW4_RS04155	COG0583	DNA-binding transcription factor activity
SMWW4_RS04160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMWW4_RS04165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMWW4_RS04170	COG2723	6-phospho-beta-galactosidase activity
SMWW4_RS04175	COG2169	Transcriptional regulator
SMWW4_RS04175	COG1917	Cupin 2, conserved barrel domain protein
SMWW4_RS04200	COG2137	regulation of response to DNA damage stimulus
SMWW4_RS04205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMWW4_RS04210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMWW4_RS04235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMWW4_RS04240	COG1238	metal cluster binding
SMWW4_RS04245	COG2918	glutathione biosynthetic process
SMWW4_RS04255	COG4536	flavin adenine dinucleotide binding
SMWW4_RS04260	COG4137	Cytochrome C assembly protein
SMWW4_RS04265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMWW4_RS04270	COG0228	four-way junction DNA binding
SMWW4_RS04275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMWW4_RS04285	COG0335	large ribosomal subunit rRNA binding
SMWW4_RS04305	COG3137	Salt-induced outer membrane protein
SMWW4_RS04310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMWW4_RS04315	COG1605	Chorismate mutase
SMWW4_RS04315	COG0287	Prephenate dehydrogenase
SMWW4_RS04320	COG1605	Chorismate mutase
SMWW4_RS04320	COG0077	Prephenate dehydratase
SMWW4_RS04325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMWW4_RS04330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMWW4_RS04335	COG0564	pseudouridine synthase activity
SMWW4_RS04345	COG0542	response to heat
SMWW4_RS04375	COG0656	L-ascorbic acid biosynthetic process
SMWW4_RS04380	COG0583	DNA-binding transcription factor activity
SMWW4_RS04385	COG2814	Major facilitator Superfamily
SMWW4_RS04395	COG1388	LysM domain
SMWW4_RS04395	COG0741	lytic transglycosylase activity
SMWW4_RS04405	COG2226	methyltransferase
SMWW4_RS04410	COG0328	RNA-DNA hybrid ribonuclease activity
SMWW4_RS04415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMWW4_RS04440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMWW4_RS04455	COG0436	Aminotransferase
SMWW4_RS04460	COG0235	Class ii aldolase
SMWW4_RS04465	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SMWW4_RS04470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SMWW4_RS04475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMWW4_RS04480	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SMWW4_RS04490	COG1960	acyl-CoA dehydrogenase activity
SMWW4_RS04495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMWW4_RS04500	COG0121	glutamine amidotransferase
SMWW4_RS04505	COG3034	peptidoglycan biosynthetic process
SMWW4_RS04510	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SMWW4_RS04515	COG1805	sodium ion transport
SMWW4_RS04520	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SMWW4_RS04525	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SMWW4_RS04530	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SMWW4_RS04535	COG2871	sodium ion transport
SMWW4_RS04540	COG1477	protein flavinylation
SMWW4_RS04545	COG2991	Protein conserved in bacteria
SMWW4_RS04550	COG0584	glycerophosphoryl diester phosphodiesterase
SMWW4_RS04555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMWW4_RS04560	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMWW4_RS04565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SMWW4_RS04570	COG1073	alpha beta
SMWW4_RS04645	COG2207	Transcriptional regulator
SMWW4_RS04650	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS04655	COG5002	protein histidine kinase activity
SMWW4_RS04660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMWW4_RS04675	COG3009	Protein conserved in bacteria
SMWW4_RS04680	COG3008	intermembrane lipid transfer
SMWW4_RS04680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMWW4_RS04685	COG2995	paraquat-inducible protein a
SMWW4_RS04690	COG2819	hydrolase of the alpha beta superfamily
SMWW4_RS04695	COG2314	TM2 domain
SMWW4_RS04710	COG1335	isochorismatase
SMWW4_RS04725	COG2207	Transcriptional regulator
SMWW4_RS04730	COG1335	isochorismatase
SMWW4_RS04775	COG3038	cytochrome b561
SMWW4_RS04780	COG0747	negative chemotaxis
SMWW4_RS04785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMWW4_RS04790	COG1733	regulation of RNA biosynthetic process
SMWW4_RS04795	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMWW4_RS04810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMWW4_RS04815	COG2207	Transcriptional regulator
SMWW4_RS04820	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS04830	COG2169	Transcriptional regulator
SMWW4_RS04830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMWW4_RS04850	COG3961	Belongs to the TPP enzyme family
SMWW4_RS04880	COG1349	DNA-binding transcription factor activity
SMWW4_RS04885	COG0346	lactoylglutathione lyase activity
SMWW4_RS04900	COG1335	isochorismatase
SMWW4_RS04910	COG3011	Protein conserved in bacteria
SMWW4_RS04920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMWW4_RS04925	COG3416	Protein conserved in bacteria
SMWW4_RS04935	COG2226	methyltransferase
SMWW4_RS04985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMWW4_RS05005	COG1595	DNA-templated transcription, initiation
SMWW4_RS05055	COG4126	flavin adenine dinucleotide binding
SMWW4_RS05060	COG3123	guanosine phosphorylase activity
SMWW4_RS05065	COG2974	May be involved in recombination
SMWW4_RS05070	COG1940	carbohydrate kinase activity
SMWW4_RS05090	COG0419	ATPase involved in DNA repair
SMWW4_RS05095	COG0420	3'-5' exonuclease activity
SMWW4_RS05100	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS05105	COG5002	protein histidine kinase activity
SMWW4_RS05130	COG0668	transmembrane transport
SMWW4_RS05135	COG0366	Alpha amylase catalytic
SMWW4_RS05145	COG0450	alkyl hydroperoxide reductase
SMWW4_RS05150	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
SMWW4_RS05155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMWW4_RS05160	COG0343	queuine tRNA-ribosyltransferase activity
SMWW4_RS05165	COG1862	Preprotein translocase
SMWW4_RS05175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMWW4_RS05180	COG4238	major outer membrane lipoprotein
SMWW4_RS05185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMWW4_RS05190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMWW4_RS05190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMWW4_RS05195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMWW4_RS05200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMWW4_RS05205	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SMWW4_RS05210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SMWW4_RS05215	COG0667	Aldo Keto reductase
SMWW4_RS05220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMWW4_RS05225	COG0142	geranyltranstransferase activity
SMWW4_RS05230	COG1722	exodeoxyribonuclease VII activity
SMWW4_RS05235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMWW4_RS05235	COG0301	tRNA thio-modification
SMWW4_RS05240	COG0693	protein deglycase activity
SMWW4_RS05245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMWW4_RS05250	COG1666	GTP binding
SMWW4_RS05255	COG2814	Major facilitator Superfamily
SMWW4_RS05260	COG0109	protoheme IX farnesyltransferase activity
SMWW4_RS05265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SMWW4_RS05270	COG1845	cytochrome c oxidase, subunit III
SMWW4_RS05275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMWW4_RS05280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMWW4_RS05285	COG2223	nitrite transmembrane transporter activity
SMWW4_RS05290	COG3056	Lipoprotein
SMWW4_RS05295	COG0271	Belongs to the BolA IbaG family
SMWW4_RS05300	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMWW4_RS05310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMWW4_RS05315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMWW4_RS05325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMWW4_RS05330	COG1555	photosystem II stabilization
SMWW4_RS05335	COG0824	Thioesterase
SMWW4_RS05340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMWW4_RS05345	COG4533	DNA binding
SMWW4_RS05350	COG0561	phosphatase activity
SMWW4_RS05360	COG1522	sequence-specific DNA binding
SMWW4_RS05365	COG1132	(ABC) transporter
SMWW4_RS05370	COG1132	(ABC) transporter
SMWW4_RS05375	COG0347	Belongs to the P(II) protein family
SMWW4_RS05380	COG0004	ammonium transporteR
SMWW4_RS05385	COG1946	Acyl-CoA thioesterase
SMWW4_RS05390	COG3126	Type III secretion system lipoprotein chaperone (YscW)
SMWW4_RS05395	COG3695	enzyme binding
SMWW4_RS05420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMWW4_RS05425	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMWW4_RS05430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMWW4_RS05435	COG0254	rRNA binding
SMWW4_RS05440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMWW4_RS05445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMWW4_RS05450	COG1309	transcriptional regulator
SMWW4_RS05455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SMWW4_RS05460	COG1196	nuclear chromosome segregation
SMWW4_RS05460	COG3264	Mechanosensitive ion channel
SMWW4_RS05475	COG2832	Protein of unknown function (DUF454)
SMWW4_RS05480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMWW4_RS05485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMWW4_RS05495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMWW4_RS05500	COG0326	Molecular chaperone. Has ATPase activity
SMWW4_RS05505	COG0563	adenylate kinase activity
SMWW4_RS05510	COG3835	regulator
SMWW4_RS05515	COG2610	gluconate transmembrane transporter activity
SMWW4_RS05520	COG1929	Belongs to the glycerate kinase type-1 family
SMWW4_RS05525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMWW4_RS05530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMWW4_RS05535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMWW4_RS05535	COG4651	solute:proton antiporter activity
SMWW4_RS05540	COG2223	nitrite transmembrane transporter activity
SMWW4_RS05545	COG0737	Belongs to the 5'-nucleotidase family
SMWW4_RS05550	COG2027	D-alanyl-D-alanine carboxypeptidase
SMWW4_RS05555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMWW4_RS05560	COG3735	TraB family
SMWW4_RS05565	COG2217	Heavy metal translocating P-type atpase
SMWW4_RS05575	COG0778	Nitroreductase
SMWW4_RS05590	COG3321	synthase
SMWW4_RS05595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMWW4_RS05600	COG0156	8-amino-7-oxononanoate synthase activity
SMWW4_RS05605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMWW4_RS05610	COG1414	Transcriptional regulator
SMWW4_RS05610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMWW4_RS05630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMWW4_RS05635	COG1960	acyl-CoA dehydrogenase activity
SMWW4_RS05640	COG0789	Transcriptional regulator
SMWW4_RS05645	COG1585	Membrane protein implicated in regulation of membrane protease activity
SMWW4_RS05650	COG0330	HflC and HflK could
SMWW4_RS05670	COG3960	tartronate-semialdehyde synthase activity
SMWW4_RS05675	COG3622	Belongs to the hyi family
SMWW4_RS05680	COG2084	Dehydrogenase
SMWW4_RS05685	COG2271	Major facilitator Superfamily
SMWW4_RS05690	COG1929	Belongs to the glycerate kinase type-1 family
SMWW4_RS05695	COG3257	ureidoglycine aminohydrolase activity
SMWW4_RS05705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMWW4_RS05710	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMWW4_RS05715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMWW4_RS05720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMWW4_RS05730	COG0549	Belongs to the carbamate kinase family
SMWW4_RS05735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMWW4_RS05740	COG3118	belongs to the thioredoxin family
SMWW4_RS05745	COG0300	oxidoreductase activity
SMWW4_RS05750	COG2755	lipolytic protein G-D-S-L family
SMWW4_RS05755	COG4181	ATPase activity
SMWW4_RS05760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SMWW4_RS05770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SMWW4_RS05775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMWW4_RS05780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMWW4_RS05785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMWW4_RS05790	COG0215	cysteine-tRNA ligase activity
SMWW4_RS05795	COG2501	S4 domain
SMWW4_RS05800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMWW4_RS05830	COG0667	Aldo Keto reductase
SMWW4_RS05845	COG2199	diguanylate cyclase activity
SMWW4_RS05850	COG1278	Cold shock
SMWW4_RS05860	COG1126	abc transporter atp-binding protein
SMWW4_RS05865	COG0765	amino acid transport
SMWW4_RS05875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS05880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMWW4_RS05885	COG1473	amidohydrolase
SMWW4_RS05895	COG2814	Major facilitator Superfamily
SMWW4_RS05900	COG1309	transcriptional regulator
SMWW4_RS05905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMWW4_RS05915	COG3706	GGDEF domain
SMWW4_RS05925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMWW4_RS05930	COG0321	lipoyl(octanoyl) transferase activity
SMWW4_RS05940	COG1686	Belongs to the peptidase S11 family
SMWW4_RS05945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMWW4_RS05950	COG0772	Belongs to the SEDS family
SMWW4_RS05955	COG0768	penicillin binding
SMWW4_RS05960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMWW4_RS05965	COG0799	negative regulation of ribosome biogenesis
SMWW4_RS05970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMWW4_RS05975	COG1466	dna polymerase III delta subunit
SMWW4_RS05980	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
SMWW4_RS05985	COG0495	leucyl-tRNA aminoacylation
SMWW4_RS05990	COG2888	peptidyl-tyrosine sulfation
SMWW4_RS06000	COG1957	nucleoside hydrolase
SMWW4_RS06005	COG1126	abc transporter atp-binding protein
SMWW4_RS06010	COG0765	amino acid transport
SMWW4_RS06015	COG0765	amino acid transport
SMWW4_RS06025	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMWW4_RS06030	COG4535	Mg2 and Co2 transporter CorC
SMWW4_RS06035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMWW4_RS06040	COG1702	phosphate starvation-inducible protein PhoH
SMWW4_RS06045	COG2824	Alkylphosphonate utilization operon protein PhnA
SMWW4_RS06050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMWW4_RS06055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMWW4_RS06090	COG0367	asparagine synthase
SMWW4_RS06095	COG3469	chitinase activity
SMWW4_RS06100	COG0647	UMP catabolic process
SMWW4_RS06105	COG1846	Transcriptional regulator
SMWW4_RS06105	COG1940	carbohydrate kinase activity
SMWW4_RS06110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMWW4_RS06115	COG0363	glucosamine-6-phosphate deaminase activity
SMWW4_RS06120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS06120	COG1263	PTS System
SMWW4_RS06120	COG2190	(PTS) system
SMWW4_RS06125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMWW4_RS06145	COG0735	belongs to the Fur family
SMWW4_RS06160	COG0596	Alpha beta hydrolase
SMWW4_RS06165	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
SMWW4_RS06170	COG0033	Phosphoglucomutase
SMWW4_RS06175	COG1695	Transcriptional regulator
SMWW4_RS06185	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS06190	COG2205	protein histidine kinase activity
SMWW4_RS06195	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMWW4_RS06200	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMWW4_RS06205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMWW4_RS06220	COG3272	Protein of unknown function (DUF1722)
SMWW4_RS06230	COG5212	phosphodiesterase
SMWW4_RS06235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMWW4_RS06240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SMWW4_RS06245	COG1984	allophanate hydrolase subunit 2
SMWW4_RS06250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMWW4_RS06270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMWW4_RS06285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SMWW4_RS06290	COG1053	succinate dehydrogenase
SMWW4_RS06295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMWW4_RS06300	COG0567	Dehydrogenase, E1 component
SMWW4_RS06305	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMWW4_RS06310	COG0045	succinate-CoA ligase (ADP-forming) activity
SMWW4_RS06315	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMWW4_RS06320	COG0737	Belongs to the 5'-nucleotidase family
SMWW4_RS06325	COG1271	oxidase subunit
SMWW4_RS06330	COG1294	oxidase, subunit
SMWW4_RS06335	COG3790	cyd operon protein YbgE
SMWW4_RS06340	COG0824	Thioesterase
SMWW4_RS06345	COG0811	peptide transport
SMWW4_RS06350	COG0848	biopolymer transport protein
SMWW4_RS06355	COG3064	Membrane
SMWW4_RS06360	COG0823	Involved in the tonB-independent uptake of proteins
SMWW4_RS06365	COG2885	chlorophyll binding
SMWW4_RS06370	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
SMWW4_RS06385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SMWW4_RS06395	COG1230	cation diffusion facilitator family transporter
SMWW4_RS06400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS06400	COG2205	protein histidine kinase activity
SMWW4_RS06405	COG2197	response regulator
SMWW4_RS06410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMWW4_RS06425	COG0588	phosphoglycerate mutase activity
SMWW4_RS06435	COG2017	converts alpha-aldose to the beta-anomer
SMWW4_RS06440	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMWW4_RS06445	COG1085	galactose-1-phosphate uridylyltransferase
SMWW4_RS06460	COG1119	ATPase activity
SMWW4_RS06465	COG2005	Transcriptional regulator
SMWW4_RS06465	COG3585	molybdate ion transport
SMWW4_RS06470	COG4774	siderophore transport
SMWW4_RS06480	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMWW4_RS06485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMWW4_RS06490	COG1120	ATPase activity
SMWW4_RS06500	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMWW4_RS06505	COG4149	molybdate abc transporter
SMWW4_RS06515	COG0561	phosphatase activity
SMWW4_RS06525	COG2706	6-phosphogluconolactonase activity
SMWW4_RS06530	COG1881	PFAM PEBP family protein
SMWW4_RS06585	COG0556	nucleotide-excision repair
SMWW4_RS06590	COG4628	conserved protein (DUF2132)
SMWW4_RS06595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMWW4_RS06600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMWW4_RS06605	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMWW4_RS06610	COG0315	cyclic pyranopterin monophosphate synthase activity
SMWW4_RS06615	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SMWW4_RS06620	COG0314	molybdopterin synthase activity
SMWW4_RS06625	COG0670	Belongs to the BI1 family
SMWW4_RS06630	COG0842	Transport permease protein
SMWW4_RS06635	COG0842	Transport permease protein
SMWW4_RS06640	COG1131	(ABC) transporter
SMWW4_RS06645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMWW4_RS06650	COG1309	transcriptional regulator
SMWW4_RS06655	COG0513	Belongs to the DEAD box helicase family
SMWW4_RS06660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMWW4_RS06665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMWW4_RS06675	COG3842	ATPase activity
SMWW4_RS06685	COG1840	ABC-type Fe3 transport system, periplasmic component
SMWW4_RS06690	COG2271	Major facilitator Superfamily
SMWW4_RS06715	COG0679	Auxin Efflux Carrier
SMWW4_RS06725	COG0469	pyruvate kinase activity
SMWW4_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS06735	COG0583	DNA-binding transcription factor activity
SMWW4_RS06755	COG0583	DNA-binding transcription factor activity
SMWW4_RS06760	COG0586	Pfam SNARE associated Golgi protein
SMWW4_RS06770	COG4977	sequence-specific DNA binding
SMWW4_RS06775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMWW4_RS06780	COG1686	Belongs to the peptidase S11 family
SMWW4_RS06800	COG2354	Protein conserved in bacteria
SMWW4_RS06815	COG3692	DNA binding
SMWW4_RS06820	COG1464	Belongs to the NlpA lipoprotein family
SMWW4_RS06830	COG0456	acetyltransferase
SMWW4_RS06855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMWW4_RS06865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMWW4_RS06870	COG0277	FAD linked oxidase domain protein
SMWW4_RS06885	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMWW4_RS06895	COG0436	Aminotransferase
SMWW4_RS06905	COG1472	Belongs to the glycosyl hydrolase 3 family
SMWW4_RS06930	COG2134	cdp-diacylglycerol pyrophosphatase
SMWW4_RS06940	COG1192	Involved in chromosome partitioning
SMWW4_RS06955	COG0583	DNA-binding transcription factor activity
SMWW4_RS06965	COG1070	Carbohydrate kinase
SMWW4_RS06970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SMWW4_RS06975	COG0697	spore germination
SMWW4_RS07015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMWW4_RS07030	COG1309	transcriptional regulator
SMWW4_RS07035	COG1464	Belongs to the NlpA lipoprotein family
SMWW4_RS07040	COG2011	ABC-type metal ion transport system permease component
SMWW4_RS07045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMWW4_RS07050	COG0519	Catalyzes the synthesis of GMP from XMP
SMWW4_RS07070	COG2084	Dehydrogenase
SMWW4_RS07085	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SMWW4_RS07095	COG3639	organic phosphonate transmembrane transporter activity
SMWW4_RS07100	COG4807	Protein conserved in bacteria
SMWW4_RS07115	COG0439	Biotin carboxylase
SMWW4_RS07120	COG1802	Transcriptional regulator
SMWW4_RS07140	COG0411	ABC transporter
SMWW4_RS07180	COG0583	DNA-binding transcription factor activity
SMWW4_RS07185	COG2897	thiosulfate sulfurtransferase activity
SMWW4_RS07190	COG0494	nUDIX hydrolase
SMWW4_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS07210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMWW4_RS07215	COG0625	glutathione transferase activity
SMWW4_RS07225	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SMWW4_RS07235	COG1335	isochorismatase
SMWW4_RS07240	COG0583	DNA-binding transcription factor activity
SMWW4_RS07255	COG1732	Glycine betaine
SMWW4_RS07260	COG1174	glycine betaine transport
SMWW4_RS07265	COG1125	glycine betaine transport
SMWW4_RS07270	COG1174	glycine betaine transport
SMWW4_RS07285	COG0583	DNA-binding transcription factor activity
SMWW4_RS07290	COG0697	spore germination
SMWW4_RS07320	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SMWW4_RS07335	COG0625	glutathione transferase activity
SMWW4_RS07345	COG1942	4-Oxalocrotonate Tautomerase
SMWW4_RS07355	COG1522	sequence-specific DNA binding
SMWW4_RS07360	COG0697	spore germination
SMWW4_RS07380	COG2079	MmgE PrpD family protein
SMWW4_RS07385	COG1280	lysine exporter protein (LysE YggA)
SMWW4_RS07395	COG0477	Major facilitator Superfamily
SMWW4_RS07405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMWW4_RS07425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMWW4_RS07430	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
SMWW4_RS07440	COG1309	transcriptional regulator
SMWW4_RS07455	COG0668	transmembrane transport
SMWW4_RS07460	COG1126	abc transporter atp-binding protein
SMWW4_RS07465	COG0765	amino acid transport
SMWW4_RS07470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS07475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMWW4_RS07490	COG2731	YhcH YjgK YiaL family protein
SMWW4_RS07500	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SMWW4_RS07505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMWW4_RS07520	COG2610	gluconate transmembrane transporter activity
SMWW4_RS07525	COG3622	Belongs to the hyi family
SMWW4_RS07530	COG0235	Class ii aldolase
SMWW4_RS07535	COG3395	kinase activity
SMWW4_RS07540	COG2084	Dehydrogenase
SMWW4_RS07545	COG1349	DNA-binding transcription factor activity
SMWW4_RS07555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMWW4_RS07560	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SMWW4_RS07580	COG5002	protein histidine kinase activity
SMWW4_RS07585	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS07590	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SMWW4_RS07595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMWW4_RS07615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMWW4_RS07620	COG1309	transcriptional regulator
SMWW4_RS07625	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS07630	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMWW4_RS07635	COG0069	glutamate synthase activity
SMWW4_RS07645	COG2200	EAL domain
SMWW4_RS07655	COG3121	Chaperone
SMWW4_RS07660	COG3188	usher protein
SMWW4_RS07670	COG3708	Transcriptional regulator
SMWW4_RS07670	COG2207	Transcriptional regulator
SMWW4_RS07675	COG0579	oxidoreductase
SMWW4_RS07685	COG0625	glutathione transferase activity
SMWW4_RS07690	COG0640	Transcriptional regulator
SMWW4_RS07700	COG1335	isochorismatase
SMWW4_RS07705	COG0583	DNA-binding transcription factor activity
SMWW4_RS07720	COG3811	Belongs to the UPF0386 family
SMWW4_RS07725	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SMWW4_RS07735	COG0583	DNA-binding transcription factor activity
SMWW4_RS07755	COG0488	(ABC) transporter
SMWW4_RS07765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMWW4_RS07775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMWW4_RS07775	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMWW4_RS07795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMWW4_RS07800	COG0303	'Molybdopterin
SMWW4_RS07815	COG4172	Belongs to the ABC transporter superfamily
SMWW4_RS07820	COG0747	negative chemotaxis
SMWW4_RS07825	COG0601	transmembrane transport
SMWW4_RS07830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMWW4_RS07855	COG0583	DNA-binding transcription factor activity
SMWW4_RS07860	COG0477	Major facilitator Superfamily
SMWW4_RS07865	COG0302	gtp cyclohydrolase
SMWW4_RS07870	COG2311	Membrane
SMWW4_RS07895	COG2949	membrane
SMWW4_RS07900	COG0281	malic enzyme
SMWW4_RS07905	COG0295	cytidine deaminase activity
SMWW4_RS07910	COG1346	cytolysis
SMWW4_RS07915	COG1380	Effector of murein hydrolase LrgA
SMWW4_RS07920	COG2814	Major facilitator Superfamily
SMWW4_RS07930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMWW4_RS07930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMWW4_RS07935	COG0489	protein tyrosine kinase activity
SMWW4_RS07945	COG0572	uridine kinase
SMWW4_RS07950	COG0717	Belongs to the dCTP deaminase family
SMWW4_RS07955	COG2982	Protein involved in outer membrane biogenesis
SMWW4_RS07960	COG3069	C4-dicarboxylate transmembrane transporter activity
SMWW4_RS07965	COG1253	flavin adenine dinucleotide binding
SMWW4_RS07970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMWW4_RS07975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMWW4_RS07985	COG0489	protein tyrosine kinase activity
SMWW4_RS07985	COG3206	protein involved in exopolysaccharide biosynthesis
SMWW4_RS08045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMWW4_RS08075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMWW4_RS08095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMWW4_RS08095	COG0140	phosphoribosyl-ATP diphosphatase activity
SMWW4_RS08100	COG0107	imidazoleglycerol-phosphate synthase activity
SMWW4_RS08105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMWW4_RS08115	COG0131	Imidazoleglycerol-phosphate dehydratase
SMWW4_RS08115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMWW4_RS08120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMWW4_RS08125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMWW4_RS08130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMWW4_RS08135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMWW4_RS08150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMWW4_RS08155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMWW4_RS08155	COG3153	acetyltransferase
SMWW4_RS08160	COG0598	Magnesium transport protein CorA
SMWW4_RS08170	COG2133	pyrroloquinoline quinone binding
SMWW4_RS08175	COG0625	glutathione transferase activity
SMWW4_RS08190	COG0626	cystathionine gamma-synthase activity
SMWW4_RS08200	COG1686	Belongs to the peptidase S11 family
SMWW4_RS08225	COG3539	Fimbrial protein
SMWW4_RS08230	COG3188	usher protein
SMWW4_RS08235	COG3121	Chaperone
SMWW4_RS08255	COG0545	Peptidyl-prolyl cis-trans isomerase
SMWW4_RS08260	COG2197	response regulator
SMWW4_RS08265	COG1760	l-serine dehydratase
SMWW4_RS08270	COG0814	amino acid
SMWW4_RS08275	COG1349	DNA-binding transcription factor activity
SMWW4_RS08280	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMWW4_RS08290	COG0671	phosphoesterase, PA-phosphatase related
SMWW4_RS08300	COG4574	serine-type endopeptidase inhibitor activity
SMWW4_RS08305	COG2985	domain, Protein
SMWW4_RS08305	COG0569	domain protein
SMWW4_RS08325	COG0189	ligase activity
SMWW4_RS08335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SMWW4_RS08340	COG3842	ATPase activity
SMWW4_RS08345	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMWW4_RS08350	COG1177	transmembrane transport
SMWW4_RS08360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMWW4_RS08365	COG2026	Addiction module toxin, RelE StbE family
SMWW4_RS08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS08380	COG4160	amino acid transport
SMWW4_RS08385	COG4215	(ABC) transporter
SMWW4_RS08390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS08395	COG1126	abc transporter atp-binding protein
SMWW4_RS08405	COG0393	Putative heavy-metal-binding
SMWW4_RS08415	COG3023	N-Acetylmuramoyl-L-alanine amidase
SMWW4_RS08420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMWW4_RS08425	COG0702	epimerase
SMWW4_RS08435	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
SMWW4_RS08440	COG0028	Belongs to the TPP enzyme family
SMWW4_RS08445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMWW4_RS08450	COG1151	hydroxylamine reductase activity
SMWW4_RS08455	COG2431	L-lysine efflux transmembrane transporter activity
SMWW4_RS08460	COG3593	DNA synthesis involved in DNA repair
SMWW4_RS08465	COG2990	Protein conserved in bacteria
SMWW4_RS08470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMWW4_RS08480	COG1278	Cold shock
SMWW4_RS08485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMWW4_RS08490	COG0542	response to heat
SMWW4_RS08495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMWW4_RS08500	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SMWW4_RS08505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SMWW4_RS08515	COG0492	ferredoxin-NADP+ reductase activity
SMWW4_RS08525	COG1674	ftsk spoiiie
SMWW4_RS08525	COG3107	peptidoglycan biosynthetic process
SMWW4_RS08530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SMWW4_RS08535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMWW4_RS08540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMWW4_RS08550	COG2814	Major facilitator Superfamily
SMWW4_RS08555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMWW4_RS08560	COG1882	Formate acetyltransferase
SMWW4_RS08565	COG2116	formate transmembrane transporter activity
SMWW4_RS08570	COG1944	ATP diphosphatase activity
SMWW4_RS08575	COG0252	asparaginase activity
SMWW4_RS08580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMWW4_RS08585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMWW4_RS08590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMWW4_RS08595	COG0539	negative regulation of cytoplasmic translation
SMWW4_RS08605	COG2333	competence protein COMEC
SMWW4_RS08605	COG0658	competence protein
SMWW4_RS08610	COG1132	(ABC) transporter
SMWW4_RS08615	COG1663	tetraacyldisaccharide 4'-kinase activity
SMWW4_RS08620	COG5383	Protein conserved in bacteria
SMWW4_RS08630	COG1278	Cold shock
SMWW4_RS08635	COG3214	Protein conserved in bacteria
SMWW4_RS08640	COG2835	tetraacyldisaccharide 4'-kinase activity
SMWW4_RS08645	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMWW4_RS08650	COG3173	Aminoglycoside phosphotransferase
SMWW4_RS08655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SMWW4_RS08660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMWW4_RS08665	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
SMWW4_RS08675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMWW4_RS08680	COG2989	Protein conserved in bacteria
SMWW4_RS08685	COG3108	Peptidase M15
SMWW4_RS08690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMWW4_RS08695	COG1448	Aminotransferase
SMWW4_RS08705	COG0017	Asparaginyl-tRNA synthetase
SMWW4_RS08710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SMWW4_RS08715	COG3706	GGDEF domain
SMWW4_RS08720	COG0308	aminopeptidase N
SMWW4_RS08730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMWW4_RS08735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMWW4_RS08740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMWW4_RS08745	COG0431	NADPH-dependent FMN reductase
SMWW4_RS08750	COG0167	dihydroorotate dehydrogenase activity
SMWW4_RS08760	COG0633	Ferredoxin
SMWW4_RS08760	COG3217	Mosc domain protein beta barrel domain protein
SMWW4_RS08765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMWW4_RS08765	COG0116	Belongs to the methyltransferase superfamily
SMWW4_RS08770	COG0488	(ABC) transporter
SMWW4_RS08775	COG2995	paraquat-inducible protein a
SMWW4_RS08780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMWW4_RS08780	COG3008	intermembrane lipid transfer
SMWW4_RS08785	COG3009	Protein conserved in bacteria
SMWW4_RS08790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMWW4_RS08800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMWW4_RS08805	COG1067	ATP-dependent peptidase activity
SMWW4_RS08825	COG3070	regulator of competence-specific genes
SMWW4_RS08830	COG1289	transmembrane transporter activity
SMWW4_RS08835	COG3304	Inner membrane component domain
SMWW4_RS08840	COG0210	DNA helicase
SMWW4_RS08845	COG1803	Methylglyoxal synthase
SMWW4_RS08855	COG1832	CoA-binding protein
SMWW4_RS08860	COG3785	DNA binding
SMWW4_RS08865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMWW4_RS08870	COG1254	Belongs to the acylphosphatase family
SMWW4_RS08875	COG2920	part of a sulfur-relay system
SMWW4_RS08880	COG0670	Belongs to the BI1 family
SMWW4_RS08905	COG2197	response regulator
SMWW4_RS08915	COG3121	Chaperone
SMWW4_RS08920	COG3188	usher protein
SMWW4_RS08930	COG0789	Transcriptional regulator
SMWW4_RS08935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMWW4_RS08940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMWW4_RS08955	COG0655	NAD(P)H dehydrogenase (quinone) activity
SMWW4_RS08985	COG1113	amino acid transport
SMWW4_RS09000	COG2271	Major facilitator Superfamily
SMWW4_RS09025	COG2814	Major facilitator Superfamily
SMWW4_RS09030	COG0156	8-amino-7-oxononanoate synthase activity
SMWW4_RS09035	COG0183	Belongs to the thiolase family
SMWW4_RS09040	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMWW4_RS09045	COG2197	response regulator
SMWW4_RS09050	COG0589	response to stress
SMWW4_RS09065	COG0531	amino acid
SMWW4_RS09070	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS09075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMWW4_RS09095	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMWW4_RS09115	COG3136	membrane protein required for alginate biosynthesis
SMWW4_RS09125	COG2197	response regulator
SMWW4_RS09130	COG0322	excinuclease ABC activity
SMWW4_RS09155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMWW4_RS09190	COG1538	Outer membrane efflux protein
SMWW4_RS09200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMWW4_RS09205	COG0322	excinuclease ABC activity
SMWW4_RS09245	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SMWW4_RS09250	COG2943	transferase activity, transferring hexosyl groups
SMWW4_RS09255	COG5645	(Lipo)protein
SMWW4_RS09270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMWW4_RS09280	COG0640	Transcriptional regulator
SMWW4_RS09305	COG2814	Major facilitator Superfamily
SMWW4_RS09315	COG1560	Kdo2-lipid A biosynthetic process
SMWW4_RS09325	COG1054	Belongs to the UPF0176 family
SMWW4_RS09330	COG2353	YceI-like domain
SMWW4_RS09335	COG3038	cytochrome b561
SMWW4_RS09340	COG0628	permease
SMWW4_RS09425	COG0418	dihydroorotase activity
SMWW4_RS09430	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SMWW4_RS09435	COG1530	ribonuclease E activity
SMWW4_RS09445	COG0564	pseudouridine synthase activity
SMWW4_RS09455	COG1399	metal-binding, possibly nucleic acid-binding protein
SMWW4_RS09460	COG0416	fatty acid biosynthetic process
SMWW4_RS09465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMWW4_RS09470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMWW4_RS09480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMWW4_RS09485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMWW4_RS09490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMWW4_RS09495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMWW4_RS09500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMWW4_RS09505	COG0470	DNA polymerase III
SMWW4_RS09510	COG0084	hydrolase, TatD family'
SMWW4_RS09515	COG1263	PTS System
SMWW4_RS09515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS09525	COG1321	iron dependent repressor
SMWW4_RS09530	COG1914	H( )-stimulated, divalent metal cation uptake system
SMWW4_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS09540	COG1733	regulation of RNA biosynthetic process
SMWW4_RS09545	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SMWW4_RS09550	COG0537	adenosine 5'-monophosphoramidase activity
SMWW4_RS09555	COG5633	Lipoprotein
SMWW4_RS09560	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
SMWW4_RS09565	COG0510	thiamine kinase activity
SMWW4_RS09575	COG3150	esterase
SMWW4_RS09580	COG1252	NADH dehydrogenase
SMWW4_RS09585	COG3134	Outer membrane lipoprotein
SMWW4_RS09600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMWW4_RS09605	COG3708	Transcriptional regulator
SMWW4_RS09605	COG2207	Transcriptional regulator
SMWW4_RS09620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMWW4_RS09625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMWW4_RS09630	COG3381	protein complex oligomerization
SMWW4_RS09635	COG2979	Protein of unknown function (DUF533)
SMWW4_RS09640	COG1770	oligopeptidase
SMWW4_RS09645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMWW4_RS09650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMWW4_RS09660	COG0583	DNA-binding transcription factor activity
SMWW4_RS09675	COG1528	Iron-storage protein
SMWW4_RS09680	COG2372	response to copper ion
SMWW4_RS09685	COG1276	copper resistance
SMWW4_RS09725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMWW4_RS09810	COG3772	lysozyme
SMWW4_RS09910	COG0739	heme binding
SMWW4_RS09910	COG1196	nuclear chromosome segregation
SMWW4_RS09910	COG0741	lytic transglycosylase activity
SMWW4_RS10010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMWW4_RS10025	COG4565	transcriptional regulatory protein
SMWW4_RS10030	COG3290	protein histidine kinase activity
SMWW4_RS10045	COG1129	ABC transporter
SMWW4_RS10050	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS10065	COG1464	Belongs to the NlpA lipoprotein family
SMWW4_RS10075	COG0589	response to stress
SMWW4_RS10080	COG3408	Glycogen debranching enzyme
SMWW4_RS10080	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SMWW4_RS10090	COG1609	Transcriptional regulator
SMWW4_RS10095	COG3250	beta-galactosidase activity
SMWW4_RS10100	COG2731	YhcH YjgK YiaL family protein
SMWW4_RS10105	COG0531	amino acid
SMWW4_RS10110	COG0640	Transcriptional regulator
SMWW4_RS10120	COG0740	serine-type endopeptidase activity
SMWW4_RS10145	COG3121	Chaperone
SMWW4_RS10175	COG0012	GTP binding
SMWW4_RS10180	COG0659	secondary active sulfate transmembrane transporter activity
SMWW4_RS10185	COG0193	aminoacyl-tRNA hydrolase activity
SMWW4_RS10195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMWW4_RS10200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMWW4_RS10205	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
SMWW4_RS10210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMWW4_RS10215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMWW4_RS10220	COG2890	protein-(glutamine-N5) methyltransferase activity
SMWW4_RS10225	COG3094	Invasion gene expression up-regulator, SirB
SMWW4_RS10230	COG2912	Transglutaminase-like superfamily
SMWW4_RS10235	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMWW4_RS10240	COG0659	secondary active sulfate transmembrane transporter activity
SMWW4_RS10245	COG4702	Belongs to the UPF0303 family
SMWW4_RS10250	COG3706	GGDEF domain
SMWW4_RS10255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMWW4_RS10260	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMWW4_RS10270	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMWW4_RS10295	COG1486	melibiose metabolic process
SMWW4_RS10300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS10300	COG1263	PTS System
SMWW4_RS10305	COG1177	transmembrane transport
SMWW4_RS10320	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMWW4_RS10370	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMWW4_RS10375	COG2850	peptidyl-arginine hydroxylation
SMWW4_RS10385	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS10390	COG1397	ADP-ribosylglycohydrolase
SMWW4_RS10395	COG2188	Transcriptional regulator
SMWW4_RS10410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMWW4_RS10415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMWW4_RS10420	COG2915	High frequency lysogenization protein hflD homolog
SMWW4_RS10430	COG0482	sulfurtransferase activity
SMWW4_RS10445	COG1187	pseudouridine synthase activity
SMWW4_RS10450	COG0538	isocitrate dehydrogenase activity
SMWW4_RS10465	COG3064	Membrane
SMWW4_RS10495	COG1942	4-Oxalocrotonate Tautomerase
SMWW4_RS10525	COG1609	Transcriptional regulator
SMWW4_RS10535	COG0673	inositol 2-dehydrogenase activity
SMWW4_RS10565	COG0589	response to stress
SMWW4_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS10575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMWW4_RS10580	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS10585	COG1917	Cupin 2, conserved barrel domain protein
SMWW4_RS10585	COG1396	sequence-specific DNA binding
SMWW4_RS10590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMWW4_RS10595	COG0174	glutamine synthetase
SMWW4_RS10600	COG0531	amino acid
SMWW4_RS10615	COG3248	Nucleoside-binding outer membrane protein
SMWW4_RS10630	COG1605	Chorismate mutase
SMWW4_RS10645	COG1228	amidohydrolase
SMWW4_RS10655	COG0402	S-adenosylhomocysteine deaminase activity
SMWW4_RS10675	COG2211	Major facilitator Superfamily
SMWW4_RS10690	COG0477	Major facilitator Superfamily
SMWW4_RS10705	COG0583	DNA-binding transcription factor activity
SMWW4_RS10715	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMWW4_RS10720	COG3493	citrate carrier protein
SMWW4_RS10780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMWW4_RS10780	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SMWW4_RS10785	COG3008	intermembrane lipid transfer
SMWW4_RS10790	COG2995	paraquat-inducible protein a
SMWW4_RS10795	COG1956	GAF domain-containing protein
SMWW4_RS10800	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
SMWW4_RS10805	COG0793	Belongs to the peptidase S41A family
SMWW4_RS10825	COG1120	ATPase activity
SMWW4_RS10830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMWW4_RS10835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMWW4_RS10840	COG0501	Belongs to the peptidase M48B family
SMWW4_RS10850	COG2814	Major facilitator Superfamily
SMWW4_RS10880	COG2188	Transcriptional regulator
SMWW4_RS10895	COG1823	symporter activity
SMWW4_RS10900	COG1988	membrane-bound metal-dependent
SMWW4_RS10905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMWW4_RS10920	COG3001	Fructosamine kinase
SMWW4_RS10925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMWW4_RS10930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMWW4_RS10935	COG1121	(ABC) transporter
SMWW4_RS10940	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMWW4_RS10970	COG0814	amino acid
SMWW4_RS10995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMWW4_RS11005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMWW4_RS11010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMWW4_RS11015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMWW4_RS11040	COG4139	cobalamin transport
SMWW4_RS11045	COG0386	Belongs to the glutathione peroxidase family
SMWW4_RS11050	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
SMWW4_RS11055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMWW4_RS11060	COG1215	transferase activity, transferring glycosyl groups
SMWW4_RS11065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMWW4_RS11065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMWW4_RS11070	COG0726	polysaccharide deacetylase
SMWW4_RS11075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SMWW4_RS11080	COG2076	Multidrug Resistance protein
SMWW4_RS11085	COG2076	Multidrug Resistance protein
SMWW4_RS11090	COG0791	NLP P60 protein
SMWW4_RS11095	COG0095	Lipoate-protein ligase
SMWW4_RS11115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMWW4_RS11120	COG4558	Periplasmic binding protein
SMWW4_RS11125	COG3720	iron ion transport
SMWW4_RS11140	COG0386	Belongs to the glutathione peroxidase family
SMWW4_RS11145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMWW4_RS11150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SMWW4_RS11160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMWW4_RS11160	COG0574	Belongs to the PEP-utilizing enzyme family
SMWW4_RS11165	COG0628	permease
SMWW4_RS11170	COG0277	FAD linked oxidase domain protein
SMWW4_RS11170	COG0247	lactate metabolic process
SMWW4_RS11175	COG2050	protein possibly involved in aromatic compounds catabolism
SMWW4_RS11185	COG0316	Belongs to the HesB IscA family
SMWW4_RS11190	COG0719	Fe-S assembly protein
SMWW4_RS11195	COG0396	ATPase activity
SMWW4_RS11200	COG0719	Fe-S assembly protein
SMWW4_RS11205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMWW4_RS11210	COG2166	iron-sulfur cluster assembly
SMWW4_RS11215	COG1388	LysM domain
SMWW4_RS11215	COG1376	ErfK ybiS ycfS ynhG family protein
SMWW4_RS11225	COG0469	pyruvate kinase activity
SMWW4_RS11240	COG0534	Mate efflux family protein
SMWW4_RS11245	COG0307	riboflavin synthase, alpha
SMWW4_RS11255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMWW4_RS11260	COG2814	Major facilitator Superfamily
SMWW4_RS11265	COG0583	DNA-binding transcription factor activity
SMWW4_RS11270	COG1609	Transcriptional regulator
SMWW4_RS11280	COG0791	NLP P60 protein
SMWW4_RS11285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SMWW4_RS11295	COG0346	lactoylglutathione lyase activity
SMWW4_RS11300	COG1902	pentaerythritol trinitrate reductase activity
SMWW4_RS11305	COG1309	transcriptional regulator
SMWW4_RS11310	COG2194	sulfuric ester hydrolase activity
SMWW4_RS11320	COG0583	DNA-binding transcription factor activity
SMWW4_RS11325	COG3313	Fe-S protein
SMWW4_RS11330	COG4989	oxidoreductase activity
SMWW4_RS11335	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SMWW4_RS11345	COG1289	transmembrane transporter activity
SMWW4_RS11350	COG1566	PFAM secretion protein HlyD family protein
SMWW4_RS11355	COG1846	Transcriptional regulator
SMWW4_RS11360	COG3133	Outer membrane lipoprotein
SMWW4_RS11365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SMWW4_RS11375	COG0259	pyridoxamine-phosphate oxidase activity
SMWW4_RS11380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMWW4_RS11390	COG0625	glutathione transferase activity
SMWW4_RS11405	COG1418	mRNA catabolic process
SMWW4_RS11440	COG3135	benzoate transporter
SMWW4_RS11445	COG1396	sequence-specific DNA binding
SMWW4_RS11450	COG1505	serine-type exopeptidase activity
SMWW4_RS11455	COG3104	oligopeptide transport
SMWW4_RS11460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMWW4_RS11470	COG4659	FMN binding
SMWW4_RS11480	COG3708	Transcriptional regulator
SMWW4_RS11480	COG2207	Transcriptional regulator
SMWW4_RS11485	COG4656	Part of a membrane complex involved in electron transport
SMWW4_RS11490	COG2878	Part of a membrane complex involved in electron transport
SMWW4_RS11495	COG4657	Part of a membrane complex involved in electron transport
SMWW4_RS11505	COG0673	inositol 2-dehydrogenase activity
SMWW4_RS11510	COG0385	Bile acid
SMWW4_RS11520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMWW4_RS11525	COG1349	DNA-binding transcription factor activity
SMWW4_RS11530	COG0494	nUDIX hydrolase
SMWW4_RS11540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMWW4_RS11545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS11545	COG1263	PTS System
SMWW4_RS11550	COG1609	Transcriptional regulator
SMWW4_RS11565	COG0583	DNA-binding transcription factor activity
SMWW4_RS11575	COG5339	Protein conserved in bacteria
SMWW4_RS11590	COG0114	fumarate hydratase activity
SMWW4_RS11605	COG2378	regulation of single-species biofilm formation
SMWW4_RS11620	COG1472	Belongs to the glycosyl hydrolase 3 family
SMWW4_RS11625	COG1649	PFAM Uncharacterised BCR, COG1649
SMWW4_RS11630	COG2814	Major facilitator Superfamily
SMWW4_RS11635	COG0583	DNA-binding transcription factor activity
SMWW4_RS11640	COG1940	carbohydrate kinase activity
SMWW4_RS11645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMWW4_RS11655	COG0789	Transcriptional regulator
SMWW4_RS11685	COG0477	Major facilitator Superfamily
SMWW4_RS11700	COG1742	UPF0060 membrane protein
SMWW4_RS11705	COG4221	oxidoreductase activity
SMWW4_RS11715	COG4772	TonB-dependent receptor
SMWW4_RS11720	COG3712	iron ion homeostasis
SMWW4_RS11725	COG1595	DNA-templated transcription, initiation
SMWW4_RS11730	COG0402	S-adenosylhomocysteine deaminase activity
SMWW4_RS11740	COG0339	signal peptide processing
SMWW4_RS11745	COG2271	Major facilitator Superfamily
SMWW4_RS11750	COG1335	isochorismatase
SMWW4_RS11755	COG3473	Maleate cis-trans isomerase
SMWW4_RS11760	COG0596	Alpha beta hydrolase
SMWW4_RS11765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMWW4_RS11770	COG2309	aminopeptidase activity
SMWW4_RS11775	COG1846	Transcriptional regulator
SMWW4_RS11780	COG2080	2 iron, 2 sulfur cluster binding
SMWW4_RS11785	COG2010	Cytochrome c
SMWW4_RS11785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMWW4_RS11840	COG2140	Oxalate decarboxylase
SMWW4_RS11875	COG0596	Alpha beta hydrolase
SMWW4_RS11925	COG2169	Transcriptional regulator
SMWW4_RS11925	COG1917	Cupin 2, conserved barrel domain protein
SMWW4_RS11945	COG2814	Major facilitator Superfamily
SMWW4_RS11950	COG1335	isochorismatase
SMWW4_RS11975	COG0768	penicillin binding
SMWW4_RS11990	COG0840	transmembrane signaling receptor activity
SMWW4_RS12015	COG1126	abc transporter atp-binding protein
SMWW4_RS12020	COG0765	amino acid transport
SMWW4_RS12030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMWW4_RS12035	COG2079	MmgE PrpD family protein
SMWW4_RS12050	COG2814	Major facilitator Superfamily
SMWW4_RS12060	COG1349	DNA-binding transcription factor activity
SMWW4_RS12065	COG0673	inositol 2-dehydrogenase activity
SMWW4_RS12070	COG0477	Major facilitator Superfamily
SMWW4_RS12095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMWW4_RS12100	COG2862	Uncharacterized protein family, UPF0114
SMWW4_RS12105	COG2814	Major facilitator Superfamily
SMWW4_RS12110	COG0583	DNA-binding transcription factor activity
SMWW4_RS12120	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMWW4_RS12135	COG1064	alcohol dehydrogenase
SMWW4_RS12145	COG3284	Transcriptional regulator
SMWW4_RS12155	COG2814	Major facilitator Superfamily
SMWW4_RS12165	COG2223	nitrite transmembrane transporter activity
SMWW4_RS12175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMWW4_RS12190	COG5001	Diguanylate cyclase
SMWW4_RS12190	COG3300	MHYT domain
SMWW4_RS12235	COG0583	DNA-binding transcription factor activity
SMWW4_RS12240	COG0076	glutamate decarboxylase activity
SMWW4_RS12245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMWW4_RS12250	COG1902	pentaerythritol trinitrate reductase activity
SMWW4_RS12250	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMWW4_RS12255	COG0789	Transcriptional regulator
SMWW4_RS12260	COG0148	phosphopyruvate hydratase activity
SMWW4_RS12270	COG1227	inorganic diphosphatase activity
SMWW4_RS12275	COG5001	Diguanylate cyclase
SMWW4_RS12275	COG3447	MASE1 domain protein
SMWW4_RS12275	COG5002	protein histidine kinase activity
SMWW4_RS12290	COG0583	DNA-binding transcription factor activity
SMWW4_RS12300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMWW4_RS12315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMWW4_RS12320	COG1063	alcohol dehydrogenase
SMWW4_RS12345	COG1082	Xylose isomerase domain protein TIM barrel
SMWW4_RS12350	COG0673	inositol 2-dehydrogenase activity
SMWW4_RS12380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMWW4_RS12415	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMWW4_RS12420	COG1280	lysine exporter protein (LysE YggA)
SMWW4_RS12440	COG1733	regulation of RNA biosynthetic process
SMWW4_RS12445	COG0477	Major facilitator Superfamily
SMWW4_RS12460	COG2382	esterase
SMWW4_RS12465	COG4774	siderophore transport
SMWW4_RS12475	COG1113	amino acid transport
SMWW4_RS12480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMWW4_RS12485	COG0318	PFAM AMP-dependent synthetase and ligase
SMWW4_RS12490	COG0693	protein deglycase activity
SMWW4_RS12505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMWW4_RS12535	COG2957	Belongs to the agmatine deiminase family
SMWW4_RS12540	COG0583	DNA-binding transcription factor activity
SMWW4_RS12550	COG0243	molybdopterin cofactor binding
SMWW4_RS12570	COG0778	Nitroreductase
SMWW4_RS12575	COG2010	Cytochrome c
SMWW4_RS12575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMWW4_RS12580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMWW4_RS12580	COG2010	Cytochrome c
SMWW4_RS12585	COG2080	2 iron, 2 sulfur cluster binding
SMWW4_RS12600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMWW4_RS12605	COG1737	Transcriptional regulator
SMWW4_RS12610	COG2723	6-phospho-beta-galactosidase activity
SMWW4_RS12615	COG3048	D-serine ammonia-lyase activity
SMWW4_RS12630	COG5507	3-demethylubiquinone-9 3-methyltransferase
SMWW4_RS12635	COG2199	diguanylate cyclase activity
SMWW4_RS12655	COG3264	Mechanosensitive ion channel
SMWW4_RS12655	COG1196	nuclear chromosome segregation
SMWW4_RS12660	COG0488	(ABC) transporter
SMWW4_RS12665	COG0483	inositol monophosphate 1-phosphatase activity
SMWW4_RS12670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMWW4_RS12680	COG2239	Acts as a magnesium transporter
SMWW4_RS12715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMWW4_RS12720	COG0697	spore germination
SMWW4_RS12765	COG0363	glucosamine-6-phosphate deaminase activity
SMWW4_RS12770	COG3158	transport of potassium into the cell
SMWW4_RS12850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMWW4_RS12870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SMWW4_RS12875	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SMWW4_RS12900	COG1175	transmembrane transport
SMWW4_RS12905	COG0395	ABC-type sugar transport system, permease component
SMWW4_RS12910	COG3842	ATPase activity
SMWW4_RS12915	COG0673	inositol 2-dehydrogenase activity
SMWW4_RS12920	COG1940	carbohydrate kinase activity
SMWW4_RS12925	COG1349	DNA-binding transcription factor activity
SMWW4_RS12930	COG2222	sugar isomerase
SMWW4_RS12945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMWW4_RS12955	COG0589	response to stress
SMWW4_RS12960	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SMWW4_RS12965	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SMWW4_RS12975	COG0531	amino acid
SMWW4_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS13000	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS13005	COG2205	protein histidine kinase activity
SMWW4_RS13010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SMWW4_RS13015	COG2267	carboxylic ester hydrolase activity
SMWW4_RS13025	COG3591	Belongs to the peptidase S1B family
SMWW4_RS13035	COG2814	Major facilitator Superfamily
SMWW4_RS13040	COG1643	Atp-dependent helicase
SMWW4_RS13045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMWW4_RS13050	COG3784	Protein of unknown function (DUF1318)
SMWW4_RS13060	COG2911	Protein conserved in bacteria
SMWW4_RS13065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMWW4_RS13070	COG3187	Heat shock protein
SMWW4_RS13075	COG3042	response to heat
SMWW4_RS13085	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMWW4_RS13085	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMWW4_RS13085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMWW4_RS13085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMWW4_RS13090	COG0037	tRNA processing
SMWW4_RS13120	COG4166	transmembrane transport
SMWW4_RS13130	COG2866	Carboxypeptidase
SMWW4_RS13135	COG4948	Mandelate Racemase Muconate Lactonizing
SMWW4_RS13140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMWW4_RS13150	COG3768	UPF0283 membrane protein
SMWW4_RS13155	COG3106	COG3106 Predicted ATPase
SMWW4_RS13165	COG1983	PspC domain protein
SMWW4_RS13175	COG1842	Phage shock protein A
SMWW4_RS13180	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SMWW4_RS13195	COG1469	GTP cyclohydrolase I activity
SMWW4_RS13210	COG4171	peptide transport system, permease
SMWW4_RS13215	COG4172	Belongs to the ABC transporter superfamily
SMWW4_RS13220	COG4172	Belongs to the ABC transporter superfamily
SMWW4_RS13225	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMWW4_RS13225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMWW4_RS13235	COG0583	DNA-binding transcription factor activity
SMWW4_RS13245	COG0243	molybdopterin cofactor binding
SMWW4_RS13250	COG0583	DNA-binding transcription factor activity
SMWW4_RS13260	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
SMWW4_RS13265	COG0477	Major facilitator Superfamily
SMWW4_RS13270	COG1473	amidohydrolase
SMWW4_RS13275	COG1966	Carbon starvation protein
SMWW4_RS13280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMWW4_RS13285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMWW4_RS13290	COG1882	Formate acetyltransferase
SMWW4_RS13295	COG1349	DNA-binding transcription factor activity
SMWW4_RS13305	COG0023	Translation Initiation Factor
SMWW4_RS13310	COG0284	orotidine-5'-phosphate decarboxylase activity
SMWW4_RS13325	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SMWW4_RS13330	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
SMWW4_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS13340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMWW4_RS13345	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS13350	COG1129	ABC transporter
SMWW4_RS13360	COG1879	ABC-type sugar transport system periplasmic component
SMWW4_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS13370	COG3958	Transketolase
SMWW4_RS13375	COG3959	Transketolase, thiamine diphosphate binding domain
SMWW4_RS13380	COG1349	DNA-binding transcription factor activity
SMWW4_RS13385	COG0671	phosphoesterase, PA-phosphatase related
SMWW4_RS13395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMWW4_RS13400	COG0583	DNA-binding transcription factor activity
SMWW4_RS13415	COG0616	signal peptide processing
SMWW4_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS13425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SMWW4_RS13430	COG1187	pseudouridine synthase activity
SMWW4_RS13510	COG0009	L-threonylcarbamoyladenylate synthase
SMWW4_RS13515	COG0613	PHP domain protein
SMWW4_RS13530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMWW4_RS13540	COG0133	tryptophan synthase activity
SMWW4_RS13545	COG0159	tryptophan synthase activity
SMWW4_RS13560	COG0727	PFAM Uncharacterised protein family (UPF0153)
SMWW4_RS13575	COG2917	probably involved in intracellular septation
SMWW4_RS13580	COG1607	acyl-coa hydrolase
SMWW4_RS13590	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMWW4_RS13595	COG2350	Protein conserved in bacteria
SMWW4_RS13615	COG0583	DNA-binding transcription factor activity
SMWW4_RS13625	COG1609	Transcriptional regulator
SMWW4_RS13640	COG1070	Carbohydrate kinase
SMWW4_RS13645	COG1129	ABC transporter
SMWW4_RS13650	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS13655	COG1879	ABC-type sugar transport system periplasmic component
SMWW4_RS13670	COG0783	Belongs to the Dps family
SMWW4_RS13680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMWW4_RS13685	COG3099	Belongs to the UPF0263 family
SMWW4_RS13695	COG0444	Belongs to the ABC transporter superfamily
SMWW4_RS13700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMWW4_RS13715	COG4166	transmembrane transport
SMWW4_RS13720	COG2095	MarC family integral membrane protein
SMWW4_RS13725	COG1454	alcohol dehydrogenase
SMWW4_RS13725	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS13750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMWW4_RS13755	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS13760	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMWW4_RS13765	COG3012	SEC-C Motif Domain Protein
SMWW4_RS13770	COG0788	formyltetrahydrofolate deformylase activity
SMWW4_RS13790	COG0708	Exodeoxyribonuclease III
SMWW4_RS13795	COG0494	nUDIX hydrolase
SMWW4_RS13805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMWW4_RS13810	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SMWW4_RS13820	COG0778	Nitroreductase
SMWW4_RS13825	COG0616	signal peptide processing
SMWW4_RS13830	COG0252	asparaginase activity
SMWW4_RS13835	COG1335	isochorismatase
SMWW4_RS13845	COG3139	Protein of unknown function (DUF1315)
SMWW4_RS13850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMWW4_RS13865	COG3713	MltA-interacting MipA family protein
SMWW4_RS13870	COG2766	serine protein kinase
SMWW4_RS13875	COG2718	Belongs to the UPF0229 family
SMWW4_RS13920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMWW4_RS13925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMWW4_RS13935	COG3443	Belongs to the bacterial solute-binding protein 9 family
SMWW4_RS13940	COG2719	SpoVR family
SMWW4_RS13945	COG2186	Transcriptional regulator
SMWW4_RS13950	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMWW4_RS13955	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMWW4_RS13965	COG2983	Belongs to the UPF0260 family
SMWW4_RS13970	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMWW4_RS13975	COG2951	lytic endotransglycosylase activity
SMWW4_RS13980	COG3100	YcgL domain-containing protein
SMWW4_RS13985	COG0850	regulation of cytokinetic process
SMWW4_RS13990	COG2894	cell division
SMWW4_RS13995	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMWW4_RS14000	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SMWW4_RS14005	COG0318	PFAM AMP-dependent synthetase and ligase
SMWW4_RS14010	COG3065	identical protein binding
SMWW4_RS14020	COG1199	ATP-dependent helicase activity
SMWW4_RS14025	COG0251	oxidation-reduction process
SMWW4_RS14030	COG2076	Multidrug Resistance protein
SMWW4_RS14035	COG2076	Multidrug Resistance protein
SMWW4_RS14040	COG0800	Aldolase
SMWW4_RS14045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SMWW4_RS14050	COG1737	Transcriptional regulator
SMWW4_RS14065	COG1560	Kdo2-lipid A biosynthetic process
SMWW4_RS14070	COG0739	heme binding
SMWW4_RS14075	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
SMWW4_RS14080	COG1121	(ABC) transporter
SMWW4_RS14085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMWW4_RS14090	COG2255	four-way junction helicase activity
SMWW4_RS14095	COG0632	four-way junction helicase activity
SMWW4_RS14100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMWW4_RS14105	COG0217	transcriptional regulatory protein
SMWW4_RS14110	COG0494	nUDIX hydrolase
SMWW4_RS14115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMWW4_RS14125	COG1335	isochorismatase
SMWW4_RS14130	COG1801	Protein of unknown function DUF72
SMWW4_RS14135	COG3788	relative of glutathione S-transferase, MAPEG superfamily
SMWW4_RS14140	COG2226	methyltransferase
SMWW4_RS14145	COG0500	methyltransferase
SMWW4_RS14150	COG0545	Peptidyl-prolyl cis-trans isomerase
SMWW4_RS14165	COG3142	Participates in the control of copper homeostasis
SMWW4_RS14170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMWW4_RS14175	COG3102	Protein conserved in bacteria
SMWW4_RS14180	COG0018	arginyl-trna synthetase
SMWW4_RS14190	COG0673	inositol 2-dehydrogenase activity
SMWW4_RS14195	COG3132	Protein of unknown function, DUF480
SMWW4_RS14200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMWW4_RS14205	COG0477	Major facilitator Superfamily
SMWW4_RS14215	COG2999	glutathione oxidoreductase activity
SMWW4_RS14235	COG3097	Belongs to the UPF0267 family
SMWW4_RS14240	COG3141	response to X-ray
SMWW4_RS14245	COG0513	Belongs to the DEAD box helicase family
SMWW4_RS14255	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMWW4_RS14260	COG3140	Belongs to the UPF0181 family
SMWW4_RS14265	COG1216	Glycosyl transferase, family 2
SMWW4_RS14275	COG0494	nUDIX hydrolase
SMWW4_RS14280	COG1760	l-serine dehydratase
SMWW4_RS14285	COG2200	EAL domain
SMWW4_RS14290	COG1253	flavin adenine dinucleotide binding
SMWW4_RS14295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMWW4_RS14295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS14300	COG3715	PTS system
SMWW4_RS14305	COG3716	PTS system mannose fructose sorbose family IID component
SMWW4_RS14310	COG4811	Protein of unknown function (DUF986)
SMWW4_RS14315	COG1971	Probably functions as a manganese efflux pump
SMWW4_RS14320	COG2226	methyltransferase
SMWW4_RS14325	COG1496	oxidoreductase activity
SMWW4_RS14345	COG1113	amino acid transport
SMWW4_RS14395	COG2207	Transcriptional regulator
SMWW4_RS14410	COG1652	LysM domain
SMWW4_RS14430	COG2988	succinylglutamate desuccinylase activity
SMWW4_RS14435	COG3724	N-succinylarginine dihydrolase activity
SMWW4_RS14440	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS14445	COG3138	arginine N-succinyltransferase
SMWW4_RS14450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMWW4_RS14460	COG4608	Belongs to the ABC transporter superfamily
SMWW4_RS14465	COG0444	Belongs to the ABC transporter superfamily
SMWW4_RS14475	COG0601	transmembrane transport
SMWW4_RS14485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMWW4_RS14490	COG1271	oxidase subunit
SMWW4_RS14495	COG1294	oxidase, subunit
SMWW4_RS14545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMWW4_RS14550	COG2181	nitrate reductase activity
SMWW4_RS14555	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SMWW4_RS14560	COG1140	nitrate reductase beta subunit
SMWW4_RS14565	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SMWW4_RS14615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMWW4_RS14620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMWW4_RS14625	COG3710	Transcriptional regulator
SMWW4_RS14630	COG2223	nitrite transmembrane transporter activity
SMWW4_RS14635	COG3850	Histidine kinase
SMWW4_RS14640	COG2197	response regulator
SMWW4_RS14645	COG4932	domain protein
SMWW4_RS14650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SMWW4_RS14660	COG0747	negative chemotaxis
SMWW4_RS14665	COG4608	Belongs to the ABC transporter superfamily
SMWW4_RS14670	COG0444	Belongs to the ABC transporter superfamily
SMWW4_RS14675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMWW4_RS14680	COG0601	transmembrane transport
SMWW4_RS14700	COG0583	DNA-binding transcription factor activity
SMWW4_RS14705	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
SMWW4_RS14710	COG4572	Cation transport regulator
SMWW4_RS14715	COG2375	cellular response to nickel ion
SMWW4_RS14720	COG0387	Pfam Sodium calcium exchanger
SMWW4_RS14730	COG4695	Portal protein
SMWW4_RS14765	COG1702	phosphate starvation-inducible protein PhoH
SMWW4_RS14775	COG2822	iron ion transport
SMWW4_RS14780	COG0672	)-iron permease
SMWW4_RS14790	COG0506	proline dehydrogenase activity
SMWW4_RS14790	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SMWW4_RS14790	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SMWW4_RS14800	COG1126	abc transporter atp-binding protein
SMWW4_RS14805	COG0765	amino acid transport
SMWW4_RS14810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS14815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SMWW4_RS14825	COG1191	sigma factor activity
SMWW4_RS14835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMWW4_RS14855	COG0583	DNA-binding transcription factor activity
SMWW4_RS14865	COG1677	Flagellar hook-basal body complex protein FliE
SMWW4_RS14875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMWW4_RS14880	COG1317	bacterial-type flagellum organization
SMWW4_RS14885	COG1157	protein secretion by the type III secretion system
SMWW4_RS14890	COG2882	bacterial-type flagellum organization
SMWW4_RS14950	COG1256	bacterial-type flagellum assembly
SMWW4_RS14985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SMWW4_RS14990	COG1558	bacterial-type flagellum-dependent cell motility
SMWW4_RS14995	COG1815	bacterial-type flagellum-dependent cell motility
SMWW4_RS15005	COG2747	anti-sigma28 factor FlgM
SMWW4_RS15010	COG3418	PFAM FlgN family protein
SMWW4_RS15030	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMWW4_RS15035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMWW4_RS15040	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SMWW4_RS15045	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS15055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMWW4_RS15060	COG0840	transmembrane signaling receptor activity
SMWW4_RS15065	COG0840	transmembrane signaling receptor activity
SMWW4_RS15070	COG0835	chemotaxis
SMWW4_RS15075	COG0643	Histidine kinase
SMWW4_RS15075	COG2198	Histidine kinase
SMWW4_RS15110	COG0589	response to stress
SMWW4_RS15115	COG2130	NADP-dependent
SMWW4_RS15120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SMWW4_RS15290	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SMWW4_RS15295	COG3483	tryptophan 2,3-dioxygenase activity
SMWW4_RS15300	COG1609	Transcriptional regulator
SMWW4_RS15345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMWW4_RS15350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMWW4_RS15370	COG3781	membrane
SMWW4_RS15375	COG2837	iron assimilation
SMWW4_RS15380	COG1414	Transcriptional regulator
SMWW4_RS15390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SMWW4_RS15395	COG0183	Belongs to the thiolase family
SMWW4_RS15400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMWW4_RS15405	COG4948	Mandelate Racemase Muconate Lactonizing
SMWW4_RS15415	COG3485	protocatechuate 3,4-dioxygenase
SMWW4_RS15425	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SMWW4_RS15440	COG1393	Belongs to the ArsC family
SMWW4_RS15445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMWW4_RS15455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SMWW4_RS15480	COG1285	pathogenesis
SMWW4_RS15485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMWW4_RS15495	COG0076	glutamate decarboxylase activity
SMWW4_RS15530	COG3321	synthase
SMWW4_RS15530	COG0604	alcohol dehydrogenase
SMWW4_RS15530	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS15540	COG0583	DNA-binding transcription factor activity
SMWW4_RS15545	COG3753	Protein conserved in bacteria
SMWW4_RS15550	COG2261	transglycosylase associated protein
SMWW4_RS15560	COG1560	Kdo2-lipid A biosynthetic process
SMWW4_RS15565	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SMWW4_RS15575	COG2203	Gaf domain
SMWW4_RS15575	COG3706	GGDEF domain
SMWW4_RS15575	COG4251	negative regulation of phosphorylation
SMWW4_RS15575	COG5001	Diguanylate cyclase
SMWW4_RS15585	COG2030	dehydratase
SMWW4_RS15585	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS15590	COG3396	Phenylacetate-CoA oxygenase
SMWW4_RS15595	COG3460	Phenylacetate-CoA oxygenase
SMWW4_RS15600	COG3396	Phenylacetate-CoA oxygenase
SMWW4_RS15605	COG2151	metal-sulfur cluster biosynthetic enzyme
SMWW4_RS15610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMWW4_RS15615	COG1024	Enoyl-CoA hydratase
SMWW4_RS15620	COG1024	Enoyl-CoA hydratase
SMWW4_RS15625	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMWW4_RS15630	COG2050	protein possibly involved in aromatic compounds catabolism
SMWW4_RS15635	COG0183	Belongs to the thiolase family
SMWW4_RS15640	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMWW4_RS15645	COG3327	negative regulation of DNA-templated transcription, initiation
SMWW4_RS15650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMWW4_RS15655	COG1113	amino acid transport
SMWW4_RS15675	COG0583	DNA-binding transcription factor activity
SMWW4_RS15680	COG0625	glutathione transferase activity
SMWW4_RS15720	COG0667	Aldo Keto reductase
SMWW4_RS15725	COG4772	TonB-dependent receptor
SMWW4_RS15730	COG4993	Dehydrogenase
SMWW4_RS15745	COG0534	Mate efflux family protein
SMWW4_RS15785	COG3121	Chaperone
SMWW4_RS15810	COG0561	phosphatase activity
SMWW4_RS15825	COG2197	response regulator
SMWW4_RS15955	COG3228	Belongs to the MtfA family
SMWW4_RS15965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMWW4_RS15970	COG4977	sequence-specific DNA binding
SMWW4_RS15980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMWW4_RS15985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SMWW4_RS15990	COG1116	anion transmembrane transporter activity
SMWW4_RS15995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMWW4_RS16000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMWW4_RS16015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMWW4_RS16030	COG3238	Protein conserved in bacteria
SMWW4_RS16035	COG1247	-acetyltransferase
SMWW4_RS16055	COG0583	DNA-binding transcription factor activity
SMWW4_RS16070	COG2814	Major facilitator Superfamily
SMWW4_RS16080	COG2011	ABC-type metal ion transport system permease component
SMWW4_RS16100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMWW4_RS16120	COG4172	Belongs to the ABC transporter superfamily
SMWW4_RS16125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMWW4_RS16135	COG0747	negative chemotaxis
SMWW4_RS16145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMWW4_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS16170	COG1169	isochorismate synthase
SMWW4_RS16195	COG0471	metal ion transport
SMWW4_RS16200	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SMWW4_RS16210	COG3051	citrate lyase alpha subunit
SMWW4_RS16215	COG2301	Belongs to the HpcH HpaI aldolase family
SMWW4_RS16220	COG3052	prosthetic group binding
SMWW4_RS16225	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMWW4_RS16230	COG4565	transcriptional regulatory protein
SMWW4_RS16235	COG3250	beta-galactosidase activity
SMWW4_RS16245	COG0300	oxidoreductase activity
SMWW4_RS16250	COG2207	Transcriptional regulator
SMWW4_RS16255	COG0667	Aldo Keto reductase
SMWW4_RS16305	COG2197	response regulator
SMWW4_RS16320	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS16325	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SMWW4_RS16355	COG2070	2-Nitropropane dioxygenase
SMWW4_RS16375	COG2271	Major facilitator Superfamily
SMWW4_RS16405	COG0411	ABC transporter
SMWW4_RS16430	COG1902	pentaerythritol trinitrate reductase activity
SMWW4_RS16445	COG4221	oxidoreductase activity
SMWW4_RS16450	COG0702	epimerase
SMWW4_RS16455	COG1073	alpha beta
SMWW4_RS16460	COG1073	alpha beta
SMWW4_RS16465	COG0583	DNA-binding transcription factor activity
SMWW4_RS16490	COG0583	DNA-binding transcription factor activity
SMWW4_RS16500	COG0456	acetyltransferase
SMWW4_RS16515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMWW4_RS16520	COG0156	8-amino-7-oxononanoate synthase activity
SMWW4_RS16525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMWW4_RS16530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMWW4_RS16535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMWW4_RS16540	COG2244	polysaccharide biosynthetic process
SMWW4_RS16550	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
SMWW4_RS16555	COG0795	lipopolysaccharide-transporting ATPase activity
SMWW4_RS16565	COG0463	Glycosyl transferase, family 2
SMWW4_RS16585	COG0583	DNA-binding transcription factor activity
SMWW4_RS16595	COG1609	Transcriptional regulator
SMWW4_RS16605	COG3623	hexulose-6-phosphate isomerase
SMWW4_RS16610	COG1070	Carbohydrate kinase
SMWW4_RS16615	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS16625	COG1879	ABC-type sugar transport system periplasmic component
SMWW4_RS16630	COG1063	alcohol dehydrogenase
SMWW4_RS16640	COG1473	amidohydrolase
SMWW4_RS16645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS16650	COG2926	Belongs to the UPF0265 family
SMWW4_RS16655	COG1289	transmembrane transporter activity
SMWW4_RS16660	COG3023	N-Acetylmuramoyl-L-alanine amidase
SMWW4_RS16685	COG2925	Exonuclease
SMWW4_RS16690	COG0531	amino acid
SMWW4_RS16695	COG0174	glutamine synthetase
SMWW4_RS16700	COG1917	Cupin 2, conserved barrel domain protein
SMWW4_RS16700	COG1396	sequence-specific DNA binding
SMWW4_RS16705	COG1129	ABC transporter
SMWW4_RS16710	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS16715	COG4771	TonB-dependent receptor
SMWW4_RS16730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMWW4_RS16740	COG0833	amino acid
SMWW4_RS16745	COG0583	DNA-binding transcription factor activity
SMWW4_RS16755	COG2855	membrane
SMWW4_RS16760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMWW4_RS16770	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SMWW4_RS16770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMWW4_RS16770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMWW4_RS16775	COG1105	Belongs to the carbohydrate kinase PfkB family
SMWW4_RS16785	COG0494	nUDIX hydrolase
SMWW4_RS16790	COG3005	denitrification pathway
SMWW4_RS16795	COG0243	molybdopterin cofactor binding
SMWW4_RS16810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMWW4_RS16815	COG1312	Catalyzes the dehydration of D-mannonate
SMWW4_RS16820	COG0246	Mannitol dehydrogenase
SMWW4_RS16830	COG0523	cobalamin synthesis protein
SMWW4_RS16835	COG0671	phosphoesterase, PA-phosphatase related
SMWW4_RS16840	COG0791	NLP P60 protein
SMWW4_RS16845	COG2200	EAL domain
SMWW4_RS16850	COG4166	transmembrane transport
SMWW4_RS16855	COG4174	ABC transporter (Permease)
SMWW4_RS16860	COG4239	(ABC) transporter, permease
SMWW4_RS16865	COG4172	Belongs to the ABC transporter superfamily
SMWW4_RS16875	COG2814	Major facilitator Superfamily
SMWW4_RS16880	COG1187	pseudouridine synthase activity
SMWW4_RS16885	COG1061	Type III restriction enzyme res subunit
SMWW4_RS16890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMWW4_RS16895	COG3081	Nucleoid-associated protein
SMWW4_RS16900	COG3082	Protein of unknown function (DUF1414)
SMWW4_RS16905	COG3083	sulfuric ester hydrolase activity
SMWW4_RS16965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMWW4_RS16990	COG0346	lactoylglutathione lyase activity
SMWW4_RS17005	COG2223	nitrite transmembrane transporter activity
SMWW4_RS17010	COG0642	Histidine kinase
SMWW4_RS17010	COG2198	Histidine kinase
SMWW4_RS17015	COG2197	response regulator
SMWW4_RS17020	COG2205	protein histidine kinase activity
SMWW4_RS17020	COG0784	Response regulator, receiver
SMWW4_RS17030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMWW4_RS17035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMWW4_RS17045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMWW4_RS17070	COG0814	amino acid
SMWW4_RS17095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SMWW4_RS17100	COG0596	Alpha beta hydrolase
SMWW4_RS17105	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SMWW4_RS17110	COG4575	ribosome binding
SMWW4_RS17115	COG1063	alcohol dehydrogenase
SMWW4_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS17150	COG0028	Belongs to the TPP enzyme family
SMWW4_RS17155	COG0583	DNA-binding transcription factor activity
SMWW4_RS17160	COG1007	ATP synthesis coupled electron transport
SMWW4_RS17165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMWW4_RS17170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMWW4_RS17175	COG0713	ATP synthesis coupled electron transport
SMWW4_RS17180	COG0839	Belongs to the complex I subunit 6 family
SMWW4_RS17190	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMWW4_RS17195	COG1034	ATP synthesis coupled electron transport
SMWW4_RS17210	COG0649	NAD binding
SMWW4_RS17210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMWW4_RS17215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMWW4_RS17220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMWW4_RS17225	COG0583	DNA-binding transcription factor activity
SMWW4_RS17230	COG0436	Aminotransferase
SMWW4_RS17235	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SMWW4_RS17240	COG0471	metal ion transport
SMWW4_RS17240	COG0490	domain, Protein
SMWW4_RS17245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMWW4_RS17250	COG3013	Belongs to the UPF0304 family
SMWW4_RS17255	COG3092	negative regulation of chromosome organization
SMWW4_RS17260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMWW4_RS17265	COG0280	phosphate acetyltransferase
SMWW4_RS17265	COG0857	belongs to the CobB CobQ family
SMWW4_RS17270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMWW4_RS17275	COG3959	Transketolase, thiamine diphosphate binding domain
SMWW4_RS17280	COG3037	sugar-specific permease SgaT UlaA
SMWW4_RS17290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMWW4_RS17295	COG1609	Transcriptional regulator
SMWW4_RS17300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SMWW4_RS17305	COG0622	Phosphoesterase
SMWW4_RS17310	COG0625	glutathione transferase activity
SMWW4_RS17315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMWW4_RS17320	COG1090	epimerase
SMWW4_RS17325	COG4598	ABC transporter
SMWW4_RS17335	COG4215	(ABC) transporter
SMWW4_RS17340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMWW4_RS17345	COG0163	prenyltransferase activity
SMWW4_RS17350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMWW4_RS17355	COG1286	toxin biosynthetic process
SMWW4_RS17360	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
SMWW4_RS17365	COG0285	dihydrofolate synthase activity
SMWW4_RS17370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMWW4_RS17375	COG0586	Pfam SNARE associated Golgi protein
SMWW4_RS17385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMWW4_RS17390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMWW4_RS17400	COG0697	spore germination
SMWW4_RS17405	COG0642	Histidine kinase
SMWW4_RS17445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMWW4_RS17450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMWW4_RS17490	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMWW4_RS17495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMWW4_RS17500	COG1477	protein flavinylation
SMWW4_RS17510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMWW4_RS17515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMWW4_RS17515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMWW4_RS17525	COG3101	peptidyl-lysine hydroxylation
SMWW4_RS17530	COG0730	response to heat
SMWW4_RS17535	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
SMWW4_RS17540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMWW4_RS17545	COG2890	protein-(glutamine-N5) methyltransferase activity
SMWW4_RS17550	COG2840	Smr protein MutS2
SMWW4_RS17555	COG2062	phosphohistidine phosphatase, SixA
SMWW4_RS17560	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMWW4_RS17560	COG1024	Enoyl-CoA hydratase
SMWW4_RS17565	COG0183	Belongs to the thiolase family
SMWW4_RS17570	COG3691	Protein conserved in bacteria
SMWW4_RS17585	COG3088	subunit of a heme lyase
SMWW4_RS17585	COG4235	cytochrome complex assembly
SMWW4_RS17590	COG3088	subunit of a heme lyase
SMWW4_RS17590	COG4235	cytochrome complex assembly
SMWW4_RS17595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMWW4_RS17600	COG1138	Cytochrome C-type biogenesis protein
SMWW4_RS17605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SMWW4_RS17610	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMWW4_RS17615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMWW4_RS17620	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMWW4_RS17630	COG2116	formate transmembrane transporter activity
SMWW4_RS17640	COG2706	6-phosphogluconolactonase activity
SMWW4_RS17645	COG3708	Transcriptional regulator
SMWW4_RS17645	COG2207	Transcriptional regulator
SMWW4_RS17660	COG2197	response regulator
SMWW4_RS17670	COG0583	DNA-binding transcription factor activity
SMWW4_RS17680	COG0697	spore germination
SMWW4_RS17695	COG2951	lytic endotransglycosylase activity
SMWW4_RS17710	COG1215	transferase activity, transferring glycosyl groups
SMWW4_RS17715	COG0726	polysaccharide deacetylase
SMWW4_RS17715	COG1649	PFAM Uncharacterised BCR, COG1649
SMWW4_RS17720	COG0457	Tetratricopeptide repeat
SMWW4_RS17725	COG1598	PFAM Uncharacterised protein family UPF0150
SMWW4_RS17735	COG3038	cytochrome b561
SMWW4_RS17740	COG0436	Aminotransferase
SMWW4_RS17755	COG3275	phosphorelay sensor kinase activity
SMWW4_RS17760	COG3279	Response regulator of the LytR AlgR family
SMWW4_RS17770	COG2223	nitrite transmembrane transporter activity
SMWW4_RS17785	COG1794	racemase activity, acting on amino acids and derivatives
SMWW4_RS17800	COG3961	Belongs to the TPP enzyme family
SMWW4_RS17805	COG0667	Aldo Keto reductase
SMWW4_RS17815	COG1914	H( )-stimulated, divalent metal cation uptake system
SMWW4_RS17820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SMWW4_RS17835	COG2116	formate transmembrane transporter activity
SMWW4_RS17840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMWW4_RS17870	COG4592	Periplasmic binding protein
SMWW4_RS17875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMWW4_RS17880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMWW4_RS17885	COG1120	ATPase activity
SMWW4_RS17890	COG0747	negative chemotaxis
SMWW4_RS17910	COG4302	ethanolamine ammonia-lyase activity
SMWW4_RS17915	COG4303	Ethanolamine ammonia lyase large subunit
SMWW4_RS17930	COG0583	DNA-binding transcription factor activity
SMWW4_RS17935	COG0385	Bile acid
SMWW4_RS17940	COG3530	Putative quorum-sensing-regulated virulence factor
SMWW4_RS17945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMWW4_RS17950	COG3115	cell septum assembly
SMWW4_RS17955	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
SMWW4_RS17965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMWW4_RS17970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMWW4_RS17980	COG2205	protein histidine kinase activity
SMWW4_RS17985	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS17990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMWW4_RS18000	COG4208	sulfate ABC transporter
SMWW4_RS18005	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SMWW4_RS18015	COG2837	iron assimilation
SMWW4_RS18030	COG3111	PFAM Bacterial OB fold (BOF) protein
SMWW4_RS18035	COG0456	acetyltransferase
SMWW4_RS18040	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMWW4_RS18045	COG0408	coproporphyrinogen oxidase activity
SMWW4_RS18050	COG1671	Belongs to the UPF0178 family
SMWW4_RS18060	COG1770	oligopeptidase
SMWW4_RS18075	COG0833	amino acid
SMWW4_RS18080	COG2040	homocysteine
SMWW4_RS18125	COG0583	DNA-binding transcription factor activity
SMWW4_RS18130	COG3397	chitin binding
SMWW4_RS18145	COG2376	Dihydroxyacetone kinase
SMWW4_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS18155	COG2814	Major facilitator Superfamily
SMWW4_RS18160	COG1063	alcohol dehydrogenase
SMWW4_RS18165	COG0698	ribose 5-phosphate isomerase
SMWW4_RS18170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMWW4_RS18180	COG0494	nUDIX hydrolase
SMWW4_RS18185	COG3850	Histidine kinase
SMWW4_RS18190	COG2197	response regulator
SMWW4_RS18200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMWW4_RS18215	COG0454	-acetyltransferase
SMWW4_RS18225	COG1393	Belongs to the ArsC family
SMWW4_RS18230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMWW4_RS18235	COG1876	peptidase activity
SMWW4_RS18245	COG0400	carboxylic ester hydrolase activity
SMWW4_RS18255	COG2321	neutral zinc metallopeptidase
SMWW4_RS18260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMWW4_RS18265	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SMWW4_RS18270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMWW4_RS18275	COG2716	regulation of RNA biosynthetic process
SMWW4_RS18280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMWW4_RS18285	COG0628	permease
SMWW4_RS18310	COG1522	sequence-specific DNA binding
SMWW4_RS18330	COG4783	chaperone-mediated protein folding
SMWW4_RS18335	COG1393	Belongs to the ArsC family
SMWW4_RS18340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMWW4_RS18350	COG2261	transglycosylase associated protein
SMWW4_RS18355	COG2233	PERMEase
SMWW4_RS18360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMWW4_RS18365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMWW4_RS18370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMWW4_RS18375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMWW4_RS18390	COG3210	domain, Protein
SMWW4_RS18415	COG0573	inorganic phosphate transmembrane transporter activity
SMWW4_RS18420	COG0573	inorganic phosphate transmembrane transporter activity
SMWW4_RS18425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMWW4_RS18440	COG2239	Acts as a magnesium transporter
SMWW4_RS18445	COG5002	protein histidine kinase activity
SMWW4_RS18445	COG3447	MASE1 domain protein
SMWW4_RS18445	COG5001	Diguanylate cyclase
SMWW4_RS18460	COG0443	Heat shock 70 kDa protein
SMWW4_RS18475	COG0667	Aldo Keto reductase
SMWW4_RS18480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMWW4_RS18485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMWW4_RS18490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMWW4_RS18495	COG2814	Major facilitator Superfamily
SMWW4_RS18500	COG2205	protein histidine kinase activity
SMWW4_RS18505	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS18520	COG3422	double-strand break repair
SMWW4_RS18525	COG0826	peptidase U32
SMWW4_RS18530	COG1597	lipid kinase activity
SMWW4_RS18540	COG1063	alcohol dehydrogenase
SMWW4_RS18545	COG2271	Major facilitator Superfamily
SMWW4_RS18550	COG0246	Mannitol dehydrogenase
SMWW4_RS18560	COG1802	Transcriptional regulator
SMWW4_RS18565	COG1830	Aldolase
SMWW4_RS18570	COG3730	PTS system glucitol sorbitol-specific
SMWW4_RS18585	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS18590	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMWW4_RS18595	COG1349	DNA-binding transcription factor activity
SMWW4_RS18610	COG0351	phosphomethylpyrimidine kinase
SMWW4_RS18615	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SMWW4_RS18635	COG1289	transmembrane transporter activity
SMWW4_RS18645	COG2814	Major facilitator Superfamily
SMWW4_RS18660	COG1187	pseudouridine synthase activity
SMWW4_RS18680	COG5002	protein histidine kinase activity
SMWW4_RS18680	COG2205	protein histidine kinase activity
SMWW4_RS18680	COG0784	Response regulator, receiver
SMWW4_RS18685	COG0519	Catalyzes the synthesis of GMP from XMP
SMWW4_RS18685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMWW4_RS18690	COG0516	GMP reductase activity
SMWW4_RS18690	COG0517	IMP dehydrogenase activity
SMWW4_RS18695	COG1570	exodeoxyribonuclease VII activity
SMWW4_RS18705	COG2271	Major facilitator Superfamily
SMWW4_RS18710	COG1609	Transcriptional regulator
SMWW4_RS18725	COG1645	bacterial-type flagellum-dependent swarming motility
SMWW4_RS18735	COG1160	GTP binding
SMWW4_RS18740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMWW4_RS18745	COG2976	Protein conserved in bacteria
SMWW4_RS18750	COG0124	histidyl-tRNA synthetase
SMWW4_RS18755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMWW4_RS18760	COG1426	Protein conserved in bacteria
SMWW4_RS18770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMWW4_RS18775	COG0105	UTP biosynthetic process
SMWW4_RS18785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMWW4_RS18790	COG2975	iron-sulfur cluster assembly
SMWW4_RS18795	COG0633	Ferredoxin
SMWW4_RS18800	COG0443	Heat shock 70 kDa protein
SMWW4_RS18805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMWW4_RS18810	COG0316	Belongs to the HesB IscA family
SMWW4_RS18815	COG0822	iron-sulfur transferase activity
SMWW4_RS18820	COG1104	cysteine desulfurase activity
SMWW4_RS18825	COG1959	2 iron, 2 sulfur cluster binding
SMWW4_RS18840	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMWW4_RS18845	COG3683	transport system, periplasmic component
SMWW4_RS18850	COG3711	transcriptional antiterminator
SMWW4_RS18855	COG2814	Major facilitator Superfamily
SMWW4_RS18860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMWW4_RS18865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMWW4_RS18865	COG1017	nitric oxide dioxygenase activity
SMWW4_RS18875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMWW4_RS18880	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS18885	COG1177	transmembrane transport
SMWW4_RS18890	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMWW4_RS18895	COG3842	ATPase activity
SMWW4_RS18900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SMWW4_RS18910	COG0583	DNA-binding transcription factor activity
SMWW4_RS18915	COG0347	Belongs to the P(II) protein family
SMWW4_RS18920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMWW4_RS18920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMWW4_RS18925	COG2204	response regulator
SMWW4_RS18930	COG3170	Tfp pilus assembly protein FimV
SMWW4_RS18935	COG2205	protein histidine kinase activity
SMWW4_RS18945	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SMWW4_RS18960	COG0560	Phosphoserine phosphatase
SMWW4_RS18965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS18965	COG1263	PTS System
SMWW4_RS18970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SMWW4_RS18975	COG1737	Transcriptional regulator
SMWW4_RS18990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMWW4_RS18995	COG0736	holo-[acyl-carrier-protein] synthase activity
SMWW4_RS19000	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SMWW4_RS19005	COG1381	Involved in DNA repair and RecF pathway recombination
SMWW4_RS19010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMWW4_RS19015	COG0571	ribonuclease III activity
SMWW4_RS19025	COG0481	GTPase activity
SMWW4_RS19035	COG3086	response to oxidative stress
SMWW4_RS19040	COG3026	antisigma factor binding
SMWW4_RS19055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMWW4_RS19060	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMWW4_RS19065	COG0513	Belongs to the DEAD box helicase family
SMWW4_RS19085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMWW4_RS19090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMWW4_RS19095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMWW4_RS19100	COG0497	DNA recombination
SMWW4_RS19105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMWW4_RS19110	COG2914	Belongs to the UPF0125 (RnfH) family
SMWW4_RS19115	COG2867	negative regulation of translational initiation
SMWW4_RS19120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMWW4_RS19125	COG1566	PFAM secretion protein HlyD family protein
SMWW4_RS19140	COG0583	DNA-binding transcription factor activity
SMWW4_RS19145	COG3182	Iron-regulated membrane protein
SMWW4_RS19155	COG2197	response regulator
SMWW4_RS19165	COG3539	Fimbrial protein
SMWW4_RS19180	COG3121	Chaperone
SMWW4_RS19195	COG3188	usher protein
SMWW4_RS19225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMWW4_RS19240	COG2188	Transcriptional regulator
SMWW4_RS19245	COG2149	membrane
SMWW4_RS19255	COG0641	radical SAM
SMWW4_RS19260	COG3121	Chaperone
SMWW4_RS19305	COG2388	GCN5-related N-acetyl-transferase
SMWW4_RS19310	COG3592	Divergent 4Fe-4S mono-cluster
SMWW4_RS19315	COG2259	Doxx family
SMWW4_RS19320	COG2840	Smr protein MutS2
SMWW4_RS19340	COG0477	Major facilitator Superfamily
SMWW4_RS19350	COG0477	Major facilitator Superfamily
SMWW4_RS19365	COG4575	ribosome binding
SMWW4_RS19375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMWW4_RS19380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMWW4_RS19385	COG1780	Probably involved in ribonucleotide reductase function
SMWW4_RS19405	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS19410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMWW4_RS19415	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMWW4_RS19420	COG3493	citrate carrier protein
SMWW4_RS19440	COG4176	ABC-type proline glycine betaine transport system permease component
SMWW4_RS19445	COG2113	Glycine betaine
SMWW4_RS19450	COG0583	DNA-binding transcription factor activity
SMWW4_RS19455	COG2814	Major facilitator Superfamily
SMWW4_RS19460	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SMWW4_RS19470	COG1846	Transcriptional regulator
SMWW4_RS19480	COG1566	PFAM secretion protein HlyD family protein
SMWW4_RS19485	COG2814	Major facilitator Superfamily
SMWW4_RS19490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMWW4_RS19495	COG3118	belongs to the thioredoxin family
SMWW4_RS19500	COG3148	PFAM DTW domain containing protein
SMWW4_RS19510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMWW4_RS19515	COG0477	Major facilitator Superfamily
SMWW4_RS19545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMWW4_RS19555	COG2011	ABC-type metal ion transport system permease component
SMWW4_RS19570	COG1720	tRNA m6t6A37 methyltransferase activity
SMWW4_RS19575	COG0442	prolyl-tRNA aminoacylation
SMWW4_RS19580	COG3015	lipoprotein NlpE involved in copper resistance
SMWW4_RS19585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMWW4_RS19600	COG4568	rho-dependent transcription termination
SMWW4_RS19610	COG0037	tRNA processing
SMWW4_RS19615	COG3104	oligopeptide transport
SMWW4_RS19625	COG0531	amino acid
SMWW4_RS19630	COG3710	Transcriptional regulator
SMWW4_RS19635	COG0346	lactoylglutathione lyase activity
SMWW4_RS19640	COG1982	Orn Lys Arg decarboxylase major
SMWW4_RS19645	COG0825	malonyl-CoA metabolic process
SMWW4_RS19655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMWW4_RS19660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMWW4_RS19665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMWW4_RS19670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMWW4_RS19675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMWW4_RS19680	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
SMWW4_RS19685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMWW4_RS19690	COG0750	zinc metalloprotease
SMWW4_RS19695	COG0575	Belongs to the CDS family
SMWW4_RS19700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMWW4_RS19705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMWW4_RS19710	COG0233	cytoplasmic translational termination
SMWW4_RS19715	COG0528	UMP kinase activity
SMWW4_RS19725	COG0052	Belongs to the universal ribosomal protein uS2 family
SMWW4_RS19735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMWW4_RS19755	COG0564	pseudouridine synthase activity
SMWW4_RS19760	COG4953	penicillin-binding protein 1C
SMWW4_RS19765	COG2373	Large extracellular alpha-helical protein
SMWW4_RS19770	COG3098	single-species biofilm formation
SMWW4_RS19775	COG2814	Major facilitator Superfamily
SMWW4_RS19790	COG1611	Belongs to the LOG family
SMWW4_RS19795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMWW4_RS19800	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
SMWW4_RS19805	COG2363	Small membrane protein
SMWW4_RS19810	COG0583	DNA-binding transcription factor activity
SMWW4_RS19820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMWW4_RS19825	COG2166	iron-sulfur cluster assembly
SMWW4_RS19830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMWW4_RS19835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SMWW4_RS19855	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMWW4_RS19860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMWW4_RS19860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SMWW4_RS19865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMWW4_RS19870	COG1074	ATP-dependent DNA helicase activity
SMWW4_RS19875	COG1025	Belongs to the peptidase M16 family
SMWW4_RS19880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SMWW4_RS19900	COG2165	general secretion pathway protein
SMWW4_RS19905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMWW4_RS19910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMWW4_RS19920	COG0494	nUDIX hydrolase
SMWW4_RS19925	COG3066	DNA modification
SMWW4_RS19930	COG0861	Integral membrane protein TerC family
SMWW4_RS19940	COG0667	Aldo Keto reductase
SMWW4_RS19945	COG0477	Major facilitator Superfamily
SMWW4_RS19950	COG0204	Acyl-transferase
SMWW4_RS19950	COG0318	PFAM AMP-dependent synthetase and ligase
SMWW4_RS19960	COG1609	Transcriptional regulator
SMWW4_RS19965	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SMWW4_RS19980	COG0583	DNA-binding transcription factor activity
SMWW4_RS19985	COG0583	DNA-binding transcription factor activity
SMWW4_RS20005	COG4178	(ABC) transporter
SMWW4_RS20015	COG3716	PTS system mannose fructose sorbose family IID component
SMWW4_RS20020	COG3715	PTS system
SMWW4_RS20025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMWW4_RS20035	COG1349	DNA-binding transcription factor activity
SMWW4_RS20040	COG2807	transmembrane transport
SMWW4_RS20045	COG4615	Cyclic peptide transporter
SMWW4_RS20050	COG0583	DNA-binding transcription factor activity
SMWW4_RS20055	COG1620	l-lactate permease
SMWW4_RS20060	COG1304	FMN binding
SMWW4_RS20070	COG2814	Major facilitator Superfamily
SMWW4_RS20085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMWW4_RS20090	COG1309	transcriptional regulator
SMWW4_RS20095	COG5265	(ABC) transporter
SMWW4_RS20100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SMWW4_RS20105	COG4942	peptidase
SMWW4_RS20110	COG3247	response to pH
SMWW4_RS20135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMWW4_RS20140	COG1609	Transcriptional regulator
SMWW4_RS20160	COG2731	YhcH YjgK YiaL family protein
SMWW4_RS20165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMWW4_RS20170	COG2271	Major facilitator Superfamily
SMWW4_RS20180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMWW4_RS20185	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMWW4_RS20190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMWW4_RS20195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMWW4_RS20200	COG4974	Belongs to the 'phage' integrase family
SMWW4_RS20205	COG0716	FMN binding
SMWW4_RS20215	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SMWW4_RS20220	COG0354	folic acid binding
SMWW4_RS20230	COG1272	protein, Hemolysin III
SMWW4_RS20240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMWW4_RS20245	COG1940	carbohydrate kinase activity
SMWW4_RS20250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMWW4_RS20260	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS20265	COG1129	ABC transporter
SMWW4_RS20275	COG1349	DNA-binding transcription factor activity
SMWW4_RS20290	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS20320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMWW4_RS20320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMWW4_RS20325	COG0509	glycine decarboxylation via glycine cleavage system
SMWW4_RS20330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMWW4_RS20335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMWW4_RS20340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMWW4_RS20345	COG0006	proline dipeptidase activity
SMWW4_RS20350	COG3079	Belongs to the UPF0149 family
SMWW4_RS20355	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SMWW4_RS20360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMWW4_RS20365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMWW4_RS20375	COG0583	DNA-binding transcription factor activity
SMWW4_RS20385	COG1279	arginine transmembrane transporter activity
SMWW4_RS20395	COG3122	Protein conserved in bacteria
SMWW4_RS20410	COG2271	Major facilitator Superfamily
SMWW4_RS20425	COG0191	fructose-bisphosphate aldolase activity
SMWW4_RS20430	COG0126	phosphoglycerate kinase activity
SMWW4_RS20435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMWW4_RS20440	COG0583	DNA-binding transcription factor activity
SMWW4_RS20445	COG0473	3-isopropylmalate dehydrogenase activity
SMWW4_RS20450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMWW4_RS20455	COG4638	Rieske (2fe-2S)
SMWW4_RS20465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMWW4_RS20470	COG3842	ATPase activity
SMWW4_RS20475	COG1175	transmembrane transport
SMWW4_RS20490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMWW4_RS20500	COG1114	Component of the transport system for branched-chain amino acids
SMWW4_RS20505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMWW4_RS20510	COG0501	Belongs to the peptidase M48B family
SMWW4_RS20525	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
SMWW4_RS20530	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS20535	COG2267	carboxylic ester hydrolase activity
SMWW4_RS20560	COG1414	Transcriptional regulator
SMWW4_RS20565	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS20580	COG2146	nitrite reductase [NAD(P)H] activity
SMWW4_RS20585	COG2271	Major facilitator Superfamily
SMWW4_RS20595	COG0010	Belongs to the arginase family
SMWW4_RS20600	COG1166	arginine decarboxylase activity
SMWW4_RS20605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMWW4_RS20610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMWW4_RS20615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMWW4_RS20620	COG1120	ATPase activity
SMWW4_RS20625	COG4774	siderophore transport
SMWW4_RS20630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMWW4_RS20635	COG1643	Atp-dependent helicase
SMWW4_RS20640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SMWW4_RS20645	COG1489	DNA binding
SMWW4_RS20655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMWW4_RS20660	COG0617	tRNA 3'-terminal CCA addition
SMWW4_RS20665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMWW4_RS20670	COG0642	Histidine kinase
SMWW4_RS20680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMWW4_RS20685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMWW4_RS20690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMWW4_RS20695	COG0726	polysaccharide deacetylase
SMWW4_RS20700	COG0842	Transport permease protein
SMWW4_RS20705	COG1131	(ABC) transporter
SMWW4_RS20710	COG0288	reversible hydration of carbon dioxide
SMWW4_RS20720	COG2132	Multicopper oxidase
SMWW4_RS20730	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMWW4_RS20735	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SMWW4_RS20740	COG3112	Uncharacterised protein family (UPF0231)
SMWW4_RS20750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMWW4_RS20755	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMWW4_RS20760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMWW4_RS20765	COG2186	Transcriptional regulator
SMWW4_RS20770	COG1113	amino acid transport
SMWW4_RS20775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMWW4_RS20775	COG2010	Cytochrome c
SMWW4_RS20785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMWW4_RS20785	COG2010	Cytochrome c
SMWW4_RS20795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMWW4_RS20800	COG2207	Transcriptional regulator
SMWW4_RS20800	COG3708	Transcriptional regulator
SMWW4_RS20810	COG3091	SprT-like family
SMWW4_RS20815	COG2356	endonuclease I
SMWW4_RS20820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMWW4_RS20825	COG0189	ligase activity
SMWW4_RS20830	COG1678	Uncharacterized ACR, COG1678
SMWW4_RS20835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMWW4_RS20840	COG2805	Type II/IV secretion system protein
SMWW4_RS20845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMWW4_RS20850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMWW4_RS20855	COG0762	integral membrane protein
SMWW4_RS20860	COG1872	DUF167
SMWW4_RS20870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMWW4_RS20890	COG2066	Belongs to the glutaminase family
SMWW4_RS20895	COG3171	Protein conserved in bacteria
SMWW4_RS20900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMWW4_RS20910	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SMWW4_RS20915	COG0741	lytic transglycosylase activity
SMWW4_RS20920	COG1982	Orn Lys Arg decarboxylase major
SMWW4_RS20955	COG2819	hydrolase of the alpha beta superfamily
SMWW4_RS20960	COG0454	-acetyltransferase
SMWW4_RS20985	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMWW4_RS20985	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMWW4_RS21000	COG4772	TonB-dependent receptor
SMWW4_RS21005	COG0583	DNA-binding transcription factor activity
SMWW4_RS21010	COG1473	amidohydrolase
SMWW4_RS21015	COG1473	amidohydrolase
SMWW4_RS21020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SMWW4_RS21050	COG0848	biopolymer transport protein
SMWW4_RS21065	COG0586	Pfam SNARE associated Golgi protein
SMWW4_RS21070	COG0583	DNA-binding transcription factor activity
SMWW4_RS21075	COG0604	alcohol dehydrogenase
SMWW4_RS21075	COG3321	synthase
SMWW4_RS21075	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS21080	COG2207	Transcriptional regulator
SMWW4_RS21085	COG1979	alcohol dehydrogenase
SMWW4_RS21090	COG0656	L-ascorbic acid biosynthetic process
SMWW4_RS21095	COG0741	lytic transglycosylase activity
SMWW4_RS21105	COG2186	Transcriptional regulator
SMWW4_RS21115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMWW4_RS21120	COG2211	Major facilitator Superfamily
SMWW4_RS21125	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMWW4_RS21130	COG0583	DNA-binding transcription factor activity
SMWW4_RS21135	COG2132	Multicopper oxidase
SMWW4_RS21140	COG0204	Acyl-transferase
SMWW4_RS21150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMWW4_RS21155	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMWW4_RS21160	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SMWW4_RS21165	COG0583	DNA-binding transcription factor activity
SMWW4_RS21170	COG0187	DNA topoisomerase II activity
SMWW4_RS21175	COG3150	esterase
SMWW4_RS21180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SMWW4_RS21185	COG3151	Protein conserved in bacteria
SMWW4_RS21190	COG0494	nUDIX hydrolase
SMWW4_RS21195	COG1538	Outer membrane efflux protein
SMWW4_RS21205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMWW4_RS21205	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SMWW4_RS21205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMWW4_RS21210	COG1461	Dihydroxyacetone kinase
SMWW4_RS21215	COG2376	Dihydroxyacetone kinase
SMWW4_RS21225	COG5463	Belongs to the UPF0441 family
SMWW4_RS21230	COG0754	glutathionylspermidine amidase activity
SMWW4_RS21235	COG3384	dioxygenase
SMWW4_RS21245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMWW4_RS21255	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMWW4_RS21255	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMWW4_RS21260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SMWW4_RS21265	COG3025	triphosphatase activity
SMWW4_RS21270	COG4991	sh3 domain protein
SMWW4_RS21275	COG0617	tRNA 3'-terminal CCA addition
SMWW4_RS21280	COG1968	undecaprenyl-diphosphatase activity
SMWW4_RS21285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMWW4_RS21290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMWW4_RS21295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMWW4_RS21300	COG0358	DNA primase activity
SMWW4_RS21445	COG4695	Portal protein
SMWW4_RS21485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMWW4_RS21515	COG4974	Belongs to the 'phage' integrase family
SMWW4_RS21525	COG1733	regulation of RNA biosynthetic process
SMWW4_RS21530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMWW4_RS21550	COG0625	glutathione transferase activity
SMWW4_RS21560	COG1012	belongs to the aldehyde dehydrogenase family
SMWW4_RS21565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMWW4_RS21575	COG0488	(ABC) transporter
SMWW4_RS21580	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMWW4_RS21580	COG1902	pentaerythritol trinitrate reductase activity
SMWW4_RS21585	COG2813	Specifically methylates the guanine in position
SMWW4_RS21590	COG3549	Plasmid maintenance system killer
SMWW4_RS21595	COG3093	addiction module antidote protein HigA
SMWW4_RS21600	COG1451	nucleotide metabolic process
SMWW4_RS21605	COG0673	inositol 2-dehydrogenase activity
SMWW4_RS21610	COG0519	Catalyzes the synthesis of GMP from XMP
SMWW4_RS21610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMWW4_RS21615	COG0861	Integral membrane protein TerC family
SMWW4_RS21620	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SMWW4_RS21625	COG2721	sulfolactate sulfo-lyase activity
SMWW4_RS21630	COG1904	glucuronate isomerase
SMWW4_RS21635	COG2271	Major facilitator Superfamily
SMWW4_RS21650	COG0586	Pfam SNARE associated Golgi protein
SMWW4_RS21655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMWW4_RS21665	COG4575	ribosome binding
SMWW4_RS21670	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
SMWW4_RS21680	COG2259	Doxx family
SMWW4_RS21685	COG0435	Glutathione S-transferase
SMWW4_RS21690	COG0583	DNA-binding transcription factor activity
SMWW4_RS21695	COG1741	Belongs to the pirin family
SMWW4_RS21700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SMWW4_RS21705	COG3107	peptidoglycan biosynthetic process
SMWW4_RS21710	COG0792	nuclease activity
SMWW4_RS21715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMWW4_RS21720	COG2823	Periplasmic or secreted lipoprotein
SMWW4_RS21730	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
SMWW4_RS21735	COG2198	Histidine kinase
SMWW4_RS21735	COG5002	protein histidine kinase activity
SMWW4_RS21735	COG0784	Response regulator, receiver
SMWW4_RS21740	COG1242	4 iron, 4 sulfur cluster binding
SMWW4_RS21745	COG0069	glutamate synthase activity
SMWW4_RS21745	COG0067	glutamate synthase
SMWW4_RS21745	COG0070	glutamate synthase
SMWW4_RS21750	COG0493	'glutamate synthase
SMWW4_RS21760	COG2969	positive regulation of protein catabolic process
SMWW4_RS21765	COG0625	glutathione transferase activity
SMWW4_RS21770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMWW4_RS21775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMWW4_RS21780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SMWW4_RS21785	COG3105	Protein conserved in bacteria
SMWW4_RS21790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMWW4_RS21795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMWW4_RS21800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMWW4_RS21805	COG5007	Belongs to the BolA IbaG family
SMWW4_RS21810	COG3113	response to antibiotic
SMWW4_RS21815	COG2854	intermembrane phospholipid transfer
SMWW4_RS21820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMWW4_RS21825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMWW4_RS21830	COG1127	ABC transporter
SMWW4_RS21835	COG0530	calcium, potassium:sodium antiporter activity
SMWW4_RS21840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMWW4_RS21840	COG0517	IMP dehydrogenase activity
SMWW4_RS21845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMWW4_RS21850	COG3117	lipopolysaccharide transmembrane transporter activity
SMWW4_RS21855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SMWW4_RS21860	COG1137	ATPase activity
SMWW4_RS21865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMWW4_RS21880	COG1660	Displays ATPase and GTPase activities
SMWW4_RS21885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMWW4_RS21890	COG4680	protein conserved in bacteria
SMWW4_RS21895	COG5499	transcription regulator containing HTH domain
SMWW4_RS21900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMWW4_RS21900	COG3711	transcriptional antiterminator
SMWW4_RS21920	COG3964	amidohydrolase
SMWW4_RS21950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMWW4_RS21960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMWW4_RS21970	COG2207	Transcriptional regulator
SMWW4_RS21975	COG3783	Cytochrome b(562)
SMWW4_RS21980	COG0312	modulator of DNA gyrase
SMWW4_RS21985	COG3028	Belongs to the UPF0307 family
SMWW4_RS21990	COG2732	(Barnase) inhibitor
SMWW4_RS22000	COG1289	transmembrane transporter activity
SMWW4_RS22005	COG1566	PFAM secretion protein HlyD family protein
SMWW4_RS22015	COG0583	DNA-binding transcription factor activity
SMWW4_RS22040	COG2134	cdp-diacylglycerol pyrophosphatase
SMWW4_RS22045	COG0312	modulator of DNA gyrase
SMWW4_RS22050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMWW4_RS22055	COG3164	Protein of unknown function
SMWW4_RS22060	COG1530	ribonuclease E activity
SMWW4_RS22065	COG0424	maF-like protein
SMWW4_RS22070	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SMWW4_RS22075	COG1792	Involved in formation and maintenance of cell shape
SMWW4_RS22080	COG1077	Cell shape determining protein MreB Mrl
SMWW4_RS22085	COG2199	diguanylate cyclase activity
SMWW4_RS22085	COG2200	EAL domain
SMWW4_RS22090	COG0604	alcohol dehydrogenase
SMWW4_RS22095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMWW4_RS22100	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SMWW4_RS22105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMWW4_RS22110	COG0511	ligase activity, forming carbon-carbon bonds
SMWW4_RS22115	COG0439	Biotin carboxylase
SMWW4_RS22125	COG0039	L-malate dehydrogenase activity
SMWW4_RS22135	COG2211	Major facilitator Superfamily
SMWW4_RS22145	COG3924	membrane
SMWW4_RS22150	COG4145	pantothenate transmembrane transporter activity
SMWW4_RS22155	COG2264	protein methyltransferase activity
SMWW4_RS22185	COG1560	Kdo2-lipid A biosynthetic process
SMWW4_RS22195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMWW4_RS22195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMWW4_RS22205	COG1380	Effector of murein hydrolase LrgA
SMWW4_RS22210	COG0583	DNA-binding transcription factor activity
SMWW4_RS22215	COG0025	NhaP-type Na H and K H
SMWW4_RS22220	COG2252	PERMEase
SMWW4_RS22230	COG0625	glutathione transferase activity
SMWW4_RS22245	COG0583	DNA-binding transcription factor activity
SMWW4_RS22250	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS22270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMWW4_RS22275	COG1064	alcohol dehydrogenase
SMWW4_RS22280	COG0110	maltose O-acetyltransferase activity
SMWW4_RS22285	COG2315	Protein conserved in bacteria
SMWW4_RS22290	COG0432	Pfam Uncharacterised protein family UPF0047
SMWW4_RS22295	COG1448	Aminotransferase
SMWW4_RS22300	COG1522	sequence-specific DNA binding
SMWW4_RS22320	COG0604	alcohol dehydrogenase
SMWW4_RS22330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMWW4_RS22350	COG0735	belongs to the Fur family
SMWW4_RS22355	COG3237	CsbD-like
SMWW4_RS22360	COG0534	Mate efflux family protein
SMWW4_RS22365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMWW4_RS22370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMWW4_RS22375	COG2937	Belongs to the GPAT DAPAT family
SMWW4_RS22380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMWW4_RS22385	COG3161	chorismate lyase activity
SMWW4_RS22390	COG0477	Major facilitator Superfamily
SMWW4_RS22395	COG1609	Transcriptional regulator
SMWW4_RS22410	COG4580	involved in the transport of maltose and maltodextrins
SMWW4_RS22420	COG0366	Alpha amylase catalytic
SMWW4_RS22425	COG2182	Extracellular solute-binding protein
SMWW4_RS22430	COG1175	transmembrane transport
SMWW4_RS22435	COG3833	ABC-type maltose transport systems, permease component
SMWW4_RS22440	COG3223	Belongs to the PsiE family
SMWW4_RS22450	COG0166	Belongs to the GPI family
SMWW4_RS22460	COG0527	aspartate kinase activity
SMWW4_RS22480	COG1283	sodium-dependent phosphate transmembrane transporter activity
SMWW4_RS22485	COG3842	ATPase activity
SMWW4_RS22495	COG0395	ABC-type sugar transport system, permease component
SMWW4_RS22500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMWW4_RS22510	COG2188	Transcriptional regulator
SMWW4_RS22515	COG0646	methionine synthase
SMWW4_RS22515	COG1410	methionine synthase
SMWW4_RS22520	COG1414	Transcriptional regulator
SMWW4_RS22525	COG3265	gluconokinase activity
SMWW4_RS22530	COG2610	gluconate transmembrane transporter activity
SMWW4_RS22535	COG0129	dihydroxy-acid dehydratase activity
SMWW4_RS22540	COG0800	Aldolase
SMWW4_RS22545	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
SMWW4_RS22555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMWW4_RS22560	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SMWW4_RS22595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMWW4_RS22600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMWW4_RS22605	COG0009	L-threonylcarbamoyladenylate synthase
SMWW4_RS22610	COG0551	DNA topoisomerase type I activity
SMWW4_RS22615	COG2922	Belongs to the Smg family
SMWW4_RS22620	COG0758	DNA mediated transformation
SMWW4_RS22625	COG0242	peptide deformylase activity
SMWW4_RS22630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMWW4_RS22635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMWW4_RS22635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMWW4_RS22640	COG0569	domain protein
SMWW4_RS22645	COG1970	mechanosensitive ion channel activity
SMWW4_RS22650	COG3036	rescue of stalled ribosome
SMWW4_RS22655	COG0789	Transcriptional regulator
SMWW4_RS22665	COG0203	ribosomal protein L17
SMWW4_RS22670	COG0202	RNA polymerase activity
SMWW4_RS22675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMWW4_RS22680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMWW4_RS22685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMWW4_RS22690	COG0201	protein transport
SMWW4_RS22700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMWW4_RS22705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMWW4_RS22710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMWW4_RS22745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMWW4_RS22750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMWW4_RS22760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMWW4_RS22770	COG0089	rRNA binding
SMWW4_RS22775	COG0088	Forms part of the polypeptide exit tunnel
SMWW4_RS22780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMWW4_RS22785	COG0051	transcription antitermination factor activity, RNA binding
SMWW4_RS22795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMWW4_RS22805	COG0049	tRNA binding
SMWW4_RS22815	COG2168	tRNA wobble position uridine thiolation
SMWW4_RS22820	COG2923	Belongs to the DsrF TusC family
SMWW4_RS22825	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SMWW4_RS22830	COG2964	Protein conserved in bacteria
SMWW4_RS22835	COG0545	Peptidyl-prolyl cis-trans isomerase
SMWW4_RS22840	COG2900	Belongs to the SlyX family
SMWW4_RS22845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMWW4_RS22850	COG1757	Na H antiporter
SMWW4_RS22855	COG1609	Transcriptional regulator
SMWW4_RS22860	COG1047	Peptidyl-prolyl cis-trans
SMWW4_RS22865	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
SMWW4_RS22875	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMWW4_RS22880	COG0488	(ABC) transporter
SMWW4_RS22885	COG2175	clavaminate synthase activity
SMWW4_RS22890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMWW4_RS22900	COG4521	taurine ABC transporter
SMWW4_RS22915	COG0429	hydrolase of the alpha beta-hydrolase fold
SMWW4_RS22920	COG3089	Belongs to the UPF0270 family
SMWW4_RS22925	COG3954	Phosphoribulokinase
SMWW4_RS22930	COG1765	OsmC-like protein
SMWW4_RS22935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMWW4_RS22940	COG1289	transmembrane transporter activity
SMWW4_RS22955	COG0433	COG0433 Predicted ATPase
SMWW4_RS22975	COG3275	phosphorelay sensor kinase activity
SMWW4_RS22980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMWW4_RS22990	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMWW4_RS22995	COG1486	melibiose metabolic process
SMWW4_RS23000	COG1609	Transcriptional regulator
SMWW4_RS23005	COG0738	Major facilitator superfamily
SMWW4_RS23010	COG0402	S-adenosylhomocysteine deaminase activity
SMWW4_RS23015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMWW4_RS23025	COG1648	precorrin-2 dehydrogenase activity
SMWW4_RS23025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMWW4_RS23030	COG0180	Tryptophanyl-tRNA synthetase
SMWW4_RS23035	COG0546	phosphoglycolate phosphatase activity
SMWW4_RS23055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMWW4_RS23060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMWW4_RS23065	COG4796	Type ii and iii secretion system protein
SMWW4_RS23090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMWW4_RS23095	COG0494	nUDIX hydrolase
SMWW4_RS23105	COG1011	Hydrolase
SMWW4_RS23110	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMWW4_RS23115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMWW4_RS23130	COG1487	ribonuclease activity
SMWW4_RS23150	COG0484	heat shock protein binding
SMWW4_RS23155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMWW4_RS23160	COG2183	response to ionizing radiation
SMWW4_RS23165	COG1918	ferrous iron import across plasma membrane
SMWW4_RS23190	COG1040	competence protein
SMWW4_RS23195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SMWW4_RS23195	COG0316	Belongs to the HesB IscA family
SMWW4_RS23200	COG1640	4-alpha-glucanotransferase
SMWW4_RS23205	COG0058	SHG alpha-glucan phosphorylase activity
SMWW4_RS23210	COG2909	trisaccharide binding
SMWW4_RS23215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMWW4_RS23220	COG0705	Rhomboid family
SMWW4_RS23225	COG1349	DNA-binding transcription factor activity
SMWW4_RS23230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMWW4_RS23235	COG0058	SHG alpha-glucan phosphorylase activity
SMWW4_RS23240	COG0297	glycogen (starch) synthase activity
SMWW4_RS23245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMWW4_RS23250	COG1523	belongs to the glycosyl hydrolase 13 family
SMWW4_RS23255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMWW4_RS23260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMWW4_RS23265	COG2095	MarC family integral membrane protein
SMWW4_RS23270	COG3265	gluconokinase activity
SMWW4_RS23275	COG2610	gluconate transmembrane transporter activity
SMWW4_RS23280	COG1609	Transcriptional regulator
SMWW4_RS23285	COG1741	Belongs to the pirin family
SMWW4_RS23290	COG1247	-acetyltransferase
SMWW4_RS23295	COG3191	aminopeptidase activity
SMWW4_RS23300	COG1082	Xylose isomerase domain protein TIM barrel
SMWW4_RS23305	COG1082	Xylose isomerase domain protein TIM barrel
SMWW4_RS23310	COG0673	inositol 2-dehydrogenase activity
SMWW4_RS23315	COG3962	Belongs to the TPP enzyme family
SMWW4_RS23320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMWW4_RS23340	COG3718	enzyme involved in inositol metabolism
SMWW4_RS23350	COG2814	Major facilitator Superfamily
SMWW4_RS23350	COG0477	Major facilitator Superfamily
SMWW4_RS23360	COG0390	transport system, permease component
SMWW4_RS23365	COG4619	ABC transporter
SMWW4_RS23395	COG3188	usher protein
SMWW4_RS23400	COG3121	Chaperone
SMWW4_RS23420	COG2197	response regulator
SMWW4_RS23430	COG0697	spore germination
SMWW4_RS23450	COG0583	DNA-binding transcription factor activity
SMWW4_RS23460	COG1028	Short-chain dehydrogenase reductase Sdr
SMWW4_RS23490	COG2081	HI0933 family
SMWW4_RS23495	COG0306	phosphate transporter
SMWW4_RS23510	COG0583	DNA-binding transcription factor activity
SMWW4_RS23515	COG0589	response to stress
SMWW4_RS23530	COG1129	ABC transporter
SMWW4_RS23535	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS23540	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS23555	COG0742	ribosomal rna small subunit methyltransferase
SMWW4_RS23560	COG0339	signal peptide processing
SMWW4_RS23575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SMWW4_RS23580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMWW4_RS23585	COG2318	DinB family
SMWW4_RS23600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMWW4_RS23610	COG2205	protein histidine kinase activity
SMWW4_RS23610	COG0784	Response regulator, receiver
SMWW4_RS23635	COG5441	Belongs to the UPF0261 family
SMWW4_RS23640	COG3678	ATP-independent chaperone mediated protein folding
SMWW4_RS23645	COG5001	Diguanylate cyclase
SMWW4_RS23650	COG1024	Enoyl-CoA hydratase
SMWW4_RS23655	COG1295	ribonuclease BN
SMWW4_RS23660	COG0477	Major facilitator Superfamily
SMWW4_RS23665	COG2134	cdp-diacylglycerol pyrophosphatase
SMWW4_RS23670	COG2982	Protein involved in outer membrane biogenesis
SMWW4_RS23675	COG2200	EAL domain
SMWW4_RS23680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMWW4_RS23690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMWW4_RS23715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMWW4_RS23720	COG0129	dihydroxy-acid dehydratase activity
SMWW4_RS23725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMWW4_RS23730	COG3978	acetolactate synthase activity
SMWW4_RS23740	COG2814	Major facilitator Superfamily
SMWW4_RS23750	COG3085	chromosome segregation
SMWW4_RS23795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMWW4_RS23800	COG4206	TonB-dependent receptor
SMWW4_RS23805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMWW4_RS23820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMWW4_RS23830	COG0678	peroxiredoxin activity
SMWW4_RS23830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMWW4_RS23835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMWW4_RS23845	COG0165	Argininosuccinate lyase
SMWW4_RS23850	COG0137	argininosuccinate synthase activity
SMWW4_RS23855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMWW4_RS23870	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMWW4_RS23880	COG0527	aspartate kinase activity
SMWW4_RS23880	COG0460	homoserine dehydrogenase
SMWW4_RS23885	COG0626	cystathionine gamma-synthase activity
SMWW4_RS23890	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
SMWW4_RS23895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMWW4_RS23900	COG1609	Transcriptional regulator
SMWW4_RS23905	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMWW4_RS23910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMWW4_RS23915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SMWW4_RS23920	COG1575	Belongs to the MenA family. Type 1 subfamily
SMWW4_RS23925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMWW4_RS23930	COG3074	FtsZ-dependent cytokinesis
SMWW4_RS23945	COG1494	fructose-1,6-bisphosphatase
SMWW4_RS23950	COG2814	Major facilitator Superfamily
SMWW4_RS23965	COG3152	Membrane
SMWW4_RS23975	COG0149	triose-phosphate isomerase activity
SMWW4_RS23980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SMWW4_RS23985	COG0205	6-phosphofructokinase activity
SMWW4_RS23990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMWW4_RS23995	COG3678	ATP-independent chaperone mediated protein folding
SMWW4_RS24000	COG0745	RESPONSE REGULATOR receiver
SMWW4_RS24005	COG2205	protein histidine kinase activity
SMWW4_RS24010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMWW4_RS24025	COG1045	serine acetyltransferase
SMWW4_RS24040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMWW4_RS24045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMWW4_RS24050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMWW4_RS24055	COG4942	peptidase
SMWW4_RS24060	COG2861	carbohydrate metabolic process
SMWW4_RS24070	COG0156	8-amino-7-oxononanoate synthase activity
SMWW4_RS24075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMWW4_RS24080	COG0859	PFAM glycosyl transferase family 9
SMWW4_RS24085	COG0859	PFAM glycosyl transferase family 9
SMWW4_RS24090	COG0438	transferase activity, transferring glycosyl groups
SMWW4_RS24095	COG3307	-O-antigen
SMWW4_RS24100	COG1442	glycosyl transferase family 8
SMWW4_RS24100	COG1216	Glycosyl transferase, family 2
SMWW4_RS24115	COG0859	PFAM glycosyl transferase family 9
SMWW4_RS24120	COG0438	transferase activity, transferring glycosyl groups
SMWW4_RS24125	COG0438	transferase activity, transferring glycosyl groups
SMWW4_RS24135	COG1519	Transferase
SMWW4_RS24155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMWW4_RS24160	COG2003	Belongs to the UPF0758 family
SMWW4_RS24165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMWW4_RS24170	COG0756	dUTP diphosphatase activity
SMWW4_RS24175	COG1309	transcriptional regulator
SMWW4_RS24180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMWW4_RS24185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMWW4_RS24190	COG1561	YicC-like family, N-terminal region
SMWW4_RS24200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SMWW4_RS24210	COG2860	membrane
SMWW4_RS24215	COG0194	GDP metabolic process
SMWW4_RS24220	COG1758	RNA polymerase activity
SMWW4_RS24225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMWW4_RS24230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMWW4_RS24235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMWW4_RS24240	COG0786	glutamate:sodium symporter activity
SMWW4_RS24245	COG2233	PERMEase
SMWW4_RS24250	COG2982	Protein involved in outer membrane biogenesis
SMWW4_RS24255	COG0456	acetyltransferase
SMWW4_RS24260	COG1490	D-aminoacyl-tRNA deacylase activity
SMWW4_RS24265	COG1295	ribonuclease BN
SMWW4_RS24270	COG1011	Hydrolase
SMWW4_RS24275	COG1217	gtp-binding protein TYPA
SMWW4_RS24285	COG3852	Histidine kinase
SMWW4_RS24295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMWW4_RS24300	COG3078	GTPase activator activity
SMWW4_RS24310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMWW4_RS24315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMWW4_RS24315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMWW4_RS24320	COG0204	Acyl-transferase
SMWW4_RS24325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMWW4_RS24330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SMWW4_RS24335	COG3084	Protein conserved in bacteria
SMWW4_RS24340	COG0746	molybdenum cofactor guanylyltransferase activity
SMWW4_RS24345	COG1763	Mo-molybdopterin cofactor biosynthetic process
SMWW4_RS24370	COG2186	Transcriptional regulator
SMWW4_RS24375	COG0477	Major facilitator Superfamily
SMWW4_RS24380	COG1609	Transcriptional regulator
SMWW4_RS24385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMWW4_RS24395	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMWW4_RS24400	COG1129	ABC transporter
SMWW4_RS24405	COG1869	D-ribose catabolic process
SMWW4_RS24410	COG3158	transport of potassium into the cell
SMWW4_RS24415	COG0714	Associated with various cellular activities
SMWW4_RS24420	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SMWW4_RS24425	COG2502	aspartate--ammonia ligase
SMWW4_RS24430	COG1522	sequence-specific DNA binding
SMWW4_RS24435	COG0716	FMN binding
SMWW4_RS24440	COG0445	tRNA wobble uridine modification
SMWW4_RS24445	COG0357	Ribosomal RNA small subunit methyltransferase G
SMWW4_RS24505	COG5301	cellulose 1,4-beta-cellobiosidase activity