locus-tag	class	description
HL670_RS00005	COG2200	EAL domain
HL670_RS00080	COG0784	Response regulator, receiver
HL670_RS00080	COG2205	protein histidine kinase activity
HL670_RS00100	COG2318	DinB family
HL670_RS00105	COG2831	hemolysin activation secretion protein
HL670_RS00110	COG3210	domain, Protein
HL670_RS00145	COG3188	usher protein
HL670_RS00150	COG3121	Chaperone
HL670_RS00195	COG3210	domain, Protein
HL670_RS00210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HL670_RS00235	COG0339	signal peptide processing
HL670_RS00240	COG0742	ribosomal rna small subunit methyltransferase
HL670_RS00245	COG0517	IMP dehydrogenase activity
HL670_RS00245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HL670_RS00255	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS00260	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS00265	COG1129	ABC transporter
HL670_RS00280	COG0589	response to stress
HL670_RS00295	COG0306	phosphate transporter
HL670_RS00300	COG2081	HI0933 family
HL670_RS00330	COG2995	paraquat-inducible protein a
HL670_RS00335	COG3008	intermembrane lipid transfer
HL670_RS00335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HL670_RS00370	COG2197	response regulator
HL670_RS00390	COG3539	Fimbrial protein
HL670_RS00395	COG3121	Chaperone
HL670_RS00400	COG3188	usher protein
HL670_RS00430	COG4619	ABC transporter
HL670_RS00435	COG0390	transport system, permease component
HL670_RS00445	COG2814	Major facilitator Superfamily
HL670_RS00445	COG0477	Major facilitator Superfamily
HL670_RS00455	COG3718	enzyme involved in inositol metabolism
HL670_RS00465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL670_RS00475	COG3962	Belongs to the TPP enzyme family
HL670_RS00480	COG0673	inositol 2-dehydrogenase activity
HL670_RS00485	COG1082	Xylose isomerase domain protein TIM barrel
HL670_RS00490	COG1082	Xylose isomerase domain protein TIM barrel
HL670_RS00495	COG3191	aminopeptidase activity
HL670_RS00500	COG1247	-acetyltransferase
HL670_RS00505	COG1741	Belongs to the pirin family
HL670_RS00510	COG1609	Transcriptional regulator
HL670_RS00515	COG2610	gluconate transmembrane transporter activity
HL670_RS00520	COG3265	gluconokinase activity
HL670_RS00525	COG2095	MarC family integral membrane protein
HL670_RS00530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HL670_RS00535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HL670_RS00540	COG1523	belongs to the glycosyl hydrolase 13 family
HL670_RS00545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HL670_RS00550	COG0297	glycogen (starch) synthase activity
HL670_RS00555	COG0058	SHG alpha-glucan phosphorylase activity
HL670_RS00560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HL670_RS00565	COG1349	DNA-binding transcription factor activity
HL670_RS00570	COG0705	Rhomboid family
HL670_RS00575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL670_RS00585	COG2731	YhcH YjgK YiaL family protein
HL670_RS00590	COG2271	Major facilitator Superfamily
HL670_RS00595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL670_RS00600	COG2909	trisaccharide binding
HL670_RS00605	COG0058	SHG alpha-glucan phosphorylase activity
HL670_RS00610	COG1640	4-alpha-glucanotransferase
HL670_RS00615	COG0316	Belongs to the HesB IscA family
HL670_RS00615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HL670_RS00620	COG1040	competence protein
HL670_RS00625	COG2267	carboxylic ester hydrolase activity
HL670_RS00645	COG1918	ferrous iron import across plasma membrane
HL670_RS00650	COG2183	response to ionizing radiation
HL670_RS00655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL670_RS00660	COG0745	RESPONSE REGULATOR receiver
HL670_RS00685	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HL670_RS00690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HL670_RS00695	COG1011	Hydrolase
HL670_RS00705	COG0494	nUDIX hydrolase
HL670_RS00710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HL670_RS00735	COG4796	Type ii and iii secretion system protein
HL670_RS00740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL670_RS00745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL670_RS00770	COG0180	Tryptophanyl-tRNA synthetase
HL670_RS00775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HL670_RS00775	COG1648	precorrin-2 dehydrogenase activity
HL670_RS00790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HL670_RS00795	COG0402	S-adenosylhomocysteine deaminase activity
HL670_RS00800	COG0738	Major facilitator superfamily
HL670_RS00805	COG1609	Transcriptional regulator
HL670_RS00810	COG1486	melibiose metabolic process
HL670_RS00815	COG1447	Phosphotransferase system cellobiose-specific component IIA
HL670_RS00820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL670_RS00845	COG0433	COG0433 Predicted ATPase
HL670_RS00860	COG1289	transmembrane transporter activity
HL670_RS00865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HL670_RS00870	COG1765	OsmC-like protein
HL670_RS00875	COG3954	Phosphoribulokinase
HL670_RS00880	COG3089	Belongs to the UPF0270 family
HL670_RS00885	COG0429	hydrolase of the alpha beta-hydrolase fold
HL670_RS00900	COG4521	taurine ABC transporter
HL670_RS00910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL670_RS00920	COG0488	(ABC) transporter
HL670_RS00925	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL670_RS00935	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HL670_RS00940	COG1047	Peptidyl-prolyl cis-trans
HL670_RS00945	COG2900	Belongs to the SlyX family
HL670_RS00950	COG0545	Peptidyl-prolyl cis-trans isomerase
HL670_RS00955	COG2964	Protein conserved in bacteria
HL670_RS00960	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HL670_RS00965	COG2923	Belongs to the DsrF TusC family
HL670_RS00970	COG2168	tRNA wobble position uridine thiolation
HL670_RS00975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HL670_RS00980	COG0049	tRNA binding
HL670_RS00985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL670_RS00990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL670_RS01005	COG0051	transcription antitermination factor activity, RNA binding
HL670_RS01010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HL670_RS01015	COG0088	Forms part of the polypeptide exit tunnel
HL670_RS01020	COG0089	rRNA binding
HL670_RS01030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HL670_RS01040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HL670_RS01045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HL670_RS01050	COG0255	Belongs to the universal ribosomal protein uL29 family
HL670_RS01055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HL670_RS01060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HL670_RS01065	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HL670_RS01070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HL670_RS01075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HL670_RS01080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HL670_RS01085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HL670_RS01090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HL670_RS01095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HL670_RS01100	COG1841	ribosomal large subunit assembly
HL670_RS01105	COG0200	Binds to the 23S rRNA
HL670_RS01110	COG0201	protein transport
HL670_RS01115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL670_RS01120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HL670_RS01125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HL670_RS01130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HL670_RS01135	COG0202	RNA polymerase activity
HL670_RS01140	COG0203	ribosomal protein L17
HL670_RS01150	COG0789	Transcriptional regulator
HL670_RS01155	COG3036	rescue of stalled ribosome
HL670_RS01160	COG1970	mechanosensitive ion channel activity
HL670_RS01165	COG0569	domain protein
HL670_RS01170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL670_RS01170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL670_RS01175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL670_RS01180	COG0242	peptide deformylase activity
HL670_RS01185	COG0758	DNA mediated transformation
HL670_RS01190	COG2922	Belongs to the Smg family
HL670_RS01195	COG0551	DNA topoisomerase type I activity
HL670_RS01200	COG0009	L-threonylcarbamoyladenylate synthase
HL670_RS01205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL670_RS01210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HL670_RS01245	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HL670_RS01250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HL670_RS01255	COG2224	Isocitrate lyase
HL670_RS01260	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HL670_RS01265	COG0800	Aldolase
HL670_RS01270	COG0129	dihydroxy-acid dehydratase activity
HL670_RS01275	COG2610	gluconate transmembrane transporter activity
HL670_RS01280	COG3265	gluconokinase activity
HL670_RS01285	COG1414	Transcriptional regulator
HL670_RS01295	COG2188	Transcriptional regulator
HL670_RS01310	COG4149	molybdate abc transporter
HL670_RS01320	COG3842	ATPase activity
HL670_RS01325	COG1283	sodium-dependent phosphate transmembrane transporter activity
HL670_RS01345	COG0527	aspartate kinase activity
HL670_RS01355	COG0166	Belongs to the GPI family
HL670_RS01365	COG3223	Belongs to the PsiE family
HL670_RS01370	COG3833	ABC-type maltose transport systems, permease component
HL670_RS01375	COG1175	transmembrane transport
HL670_RS01380	COG2182	Extracellular solute-binding protein
HL670_RS01385	COG0366	Alpha amylase catalytic
HL670_RS01395	COG4580	involved in the transport of maltose and maltodextrins
HL670_RS01410	COG1609	Transcriptional regulator
HL670_RS01415	COG0477	Major facilitator Superfamily
HL670_RS01420	COG3161	chorismate lyase activity
HL670_RS01425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HL670_RS01430	COG2937	Belongs to the GPAT DAPAT family
HL670_RS01435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HL670_RS01440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HL670_RS01445	COG0534	Mate efflux family protein
HL670_RS01450	COG3237	CsbD-like
HL670_RS01455	COG0735	belongs to the Fur family
HL670_RS01465	COG1595	DNA-templated transcription, initiation
HL670_RS01475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HL670_RS01485	COG0604	alcohol dehydrogenase
HL670_RS01505	COG1113	amino acid transport
HL670_RS01510	COG1522	sequence-specific DNA binding
HL670_RS01520	COG1448	Aminotransferase
HL670_RS01530	COG2315	Protein conserved in bacteria
HL670_RS01535	COG0110	maltose O-acetyltransferase activity
HL670_RS01540	COG1064	alcohol dehydrogenase
HL670_RS01545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL670_RS01550	COG0629	single-stranded DNA binding
HL670_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS01560	COG0583	DNA-binding transcription factor activity
HL670_RS01570	COG0625	glutathione transferase activity
HL670_RS01585	COG2252	PERMEase
HL670_RS01590	COG0025	NhaP-type Na H and K H
HL670_RS01595	COG0583	DNA-binding transcription factor activity
HL670_RS01600	COG1380	Effector of murein hydrolase LrgA
HL670_RS01615	COG1560	Kdo2-lipid A biosynthetic process
HL670_RS01635	COG2264	protein methyltransferase activity
HL670_RS01640	COG4145	pantothenate transmembrane transporter activity
HL670_RS01645	COG3924	membrane
HL670_RS01650	COG0439	Biotin carboxylase
HL670_RS01655	COG0511	ligase activity, forming carbon-carbon bonds
HL670_RS01660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HL670_RS01665	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HL670_RS01670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HL670_RS01675	COG0604	alcohol dehydrogenase
HL670_RS01680	COG2199	diguanylate cyclase activity
HL670_RS01680	COG2200	EAL domain
HL670_RS01685	COG1077	Cell shape determining protein MreB Mrl
HL670_RS01695	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HL670_RS01700	COG0424	maF-like protein
HL670_RS01705	COG1530	ribonuclease E activity
HL670_RS01710	COG3164	Protein of unknown function
HL670_RS01715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL670_RS01720	COG0312	modulator of DNA gyrase
HL670_RS01810	COG0583	DNA-binding transcription factor activity
HL670_RS01820	COG1566	PFAM secretion protein HlyD family protein
HL670_RS01825	COG1289	transmembrane transporter activity
HL670_RS01835	COG2732	(Barnase) inhibitor
HL670_RS01840	COG3028	Belongs to the UPF0307 family
HL670_RS01845	COG0312	modulator of DNA gyrase
HL670_RS01850	COG3783	Cytochrome b(562)
HL670_RS01855	COG2207	Transcriptional regulator
HL670_RS01865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL670_RS01875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL670_RS01905	COG3964	amidohydrolase
HL670_RS01920	COG2706	6-phosphogluconolactonase activity
HL670_RS01925	COG3711	transcriptional antiterminator
HL670_RS01925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL670_RS01930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL670_RS01935	COG1660	Displays ATPase and GTPase activities
HL670_RS01950	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HL670_RS01955	COG1137	ATPase activity
HL670_RS01960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HL670_RS01965	COG3117	lipopolysaccharide transmembrane transporter activity
HL670_RS01970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HL670_RS01975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HL670_RS01975	COG0517	IMP dehydrogenase activity
HL670_RS01980	COG0530	calcium, potassium:sodium antiporter activity
HL670_RS01985	COG1127	ABC transporter
HL670_RS01990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HL670_RS01995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HL670_RS02000	COG2854	intermembrane phospholipid transfer
HL670_RS02005	COG3113	response to antibiotic
HL670_RS02010	COG5007	Belongs to the BolA IbaG family
HL670_RS02015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HL670_RS02020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL670_RS02025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL670_RS02030	COG3105	Protein conserved in bacteria
HL670_RS02035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HL670_RS02040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HL670_RS02045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HL670_RS02050	COG0625	glutathione transferase activity
HL670_RS02055	COG2969	positive regulation of protein catabolic process
HL670_RS02060	COG0493	'glutamate synthase
HL670_RS02070	COG1242	4 iron, 4 sulfur cluster binding
HL670_RS02075	COG5002	protein histidine kinase activity
HL670_RS02075	COG2198	Histidine kinase
HL670_RS02075	COG0784	Response regulator, receiver
HL670_RS02080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HL670_RS02090	COG2823	Periplasmic or secreted lipoprotein
HL670_RS02095	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HL670_RS02100	COG0792	nuclease activity
HL670_RS02105	COG3107	peptidoglycan biosynthetic process
HL670_RS02110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HL670_RS02120	COG1741	Belongs to the pirin family
HL670_RS02125	COG0583	DNA-binding transcription factor activity
HL670_RS02130	COG0435	Glutathione S-transferase
HL670_RS02135	COG2259	Doxx family
HL670_RS02145	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HL670_RS02150	COG4575	ribosome binding
HL670_RS02160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL670_RS02165	COG0586	Pfam SNARE associated Golgi protein
HL670_RS02185	COG1904	glucuronate isomerase
HL670_RS02190	COG2721	sulfolactate sulfo-lyase activity
HL670_RS02200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HL670_RS02205	COG0861	Integral membrane protein TerC family
HL670_RS02215	COG0673	inositol 2-dehydrogenase activity
HL670_RS02220	COG1451	nucleotide metabolic process
HL670_RS02225	COG2813	Specifically methylates the guanine in position
HL670_RS02230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL670_RS02230	COG1902	pentaerythritol trinitrate reductase activity
HL670_RS02245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HL670_RS02250	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS02260	COG0625	glutathione transferase activity
HL670_RS02275	COG3663	DNA glycosylase
HL670_RS02285	COG0358	DNA primase activity
HL670_RS02290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HL670_RS02295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HL670_RS02300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HL670_RS02305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HL670_RS02310	COG1968	undecaprenyl-diphosphatase activity
HL670_RS02315	COG0617	tRNA 3'-terminal CCA addition
HL670_RS02320	COG4991	sh3 domain protein
HL670_RS02325	COG3025	triphosphatase activity
HL670_RS02330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HL670_RS02335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HL670_RS02335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HL670_RS02340	COG0531	amino acid
HL670_RS02345	COG2960	long-chain fatty acid transporting porin activity
HL670_RS02350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL670_RS02370	COG0754	glutathionylspermidine amidase activity
HL670_RS02375	COG5463	Belongs to the UPF0441 family
HL670_RS02385	COG2376	Dihydroxyacetone kinase
HL670_RS02390	COG1461	Dihydroxyacetone kinase
HL670_RS02405	COG1538	Outer membrane efflux protein
HL670_RS02410	COG0494	nUDIX hydrolase
HL670_RS02415	COG3151	Protein conserved in bacteria
HL670_RS02420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HL670_RS02425	COG3150	esterase
HL670_RS02435	COG0583	DNA-binding transcription factor activity
HL670_RS02440	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HL670_RS02445	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL670_RS02450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL670_RS02460	COG2132	Multicopper oxidase
HL670_RS02475	COG0741	lytic transglycosylase activity
HL670_RS02485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL670_RS02490	COG1447	Phosphotransferase system cellobiose-specific component IIA
HL670_RS02495	COG2723	6-phospho-beta-galactosidase activity
HL670_RS02500	COG0656	L-ascorbic acid biosynthetic process
HL670_RS02505	COG1979	alcohol dehydrogenase
HL670_RS02510	COG2207	Transcriptional regulator
HL670_RS02525	COG0586	Pfam SNARE associated Golgi protein
HL670_RS02530	COG0675	Transposase, IS605 OrfB family
HL670_RS02550	COG0848	biopolymer transport protein
HL670_RS02555	COG3609	addiction module antidote protein, CC2985 family
HL670_RS02560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL670_RS02590	COG2831	hemolysin activation secretion protein
HL670_RS02625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HL670_RS02655	COG0454	-acetyltransferase
HL670_RS02660	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HL670_RS02665	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HL670_RS02675	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL670_RS02680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HL670_RS02690	COG3260	NADH ubiquinone oxidoreductase 20
HL670_RS02695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL670_RS02700	COG3261	NADH dehydrogenase
HL670_RS02700	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HL670_RS02705	COG0650	Formate hydrogenlyase subunit 4
HL670_RS02710	COG0651	ATP synthesis coupled electron transport
HL670_RS02715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL670_RS02725	COG0375	protein maturation
HL670_RS02730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HL670_RS02735	COG0298	carbon dioxide binding
HL670_RS02740	COG0409	Hydrogenase expression formation protein
HL670_RS02745	COG0309	Hydrogenase expression formation protein (HypE)
HL670_RS02820	COG1136	(ABC) transporter
HL670_RS02845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HL670_RS02845	COG2070	2-Nitropropane dioxygenase
HL670_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS02855	COG3320	Male sterility
HL670_RS02855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL670_RS02860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL670_RS02885	COG1131	(ABC) transporter
HL670_RS02895	COG0823	Involved in the tonB-independent uptake of proteins
HL670_RS02895	COG1506	peptidase
HL670_RS02930	COG0475	glutathione-regulated potassium exporter activity
HL670_RS02950	COG1982	Orn Lys Arg decarboxylase major
HL670_RS02960	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HL670_RS02965	COG1194	a g-specific adenine glycosylase
HL670_RS02970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HL670_RS02975	COG3171	Protein conserved in bacteria
HL670_RS02980	COG2066	Belongs to the glutaminase family
HL670_RS02995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL670_RS03000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HL670_RS03005	COG1872	DUF167
HL670_RS03010	COG0762	integral membrane protein
HL670_RS03015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL670_RS03020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HL670_RS03025	COG2805	Type II/IV secretion system protein
HL670_RS03030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HL670_RS03040	COG0189	ligase activity
HL670_RS03045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HL670_RS03050	COG2356	endonuclease I
HL670_RS03055	COG3091	SprT-like family
HL670_RS03060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HL670_RS03060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HL670_RS03065	COG3708	Transcriptional regulator
HL670_RS03065	COG2207	Transcriptional regulator
HL670_RS03090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL670_RS03090	COG2010	Cytochrome c
HL670_RS03095	COG3940	Belongs to the glycosyl hydrolase 43 family
HL670_RS03100	COG2211	Major facilitator Superfamily
HL670_RS03105	COG1113	amino acid transport
HL670_RS03110	COG2186	Transcriptional regulator
HL670_RS03115	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HL670_RS03120	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL670_RS03125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL670_RS03135	COG3112	Uncharacterised protein family (UPF0231)
HL670_RS03140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HL670_RS03145	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HL670_RS03155	COG2132	Multicopper oxidase
HL670_RS03165	COG0288	reversible hydration of carbon dioxide
HL670_RS03170	COG1131	(ABC) transporter
HL670_RS03175	COG0842	Transport permease protein
HL670_RS03185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HL670_RS03190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HL670_RS03195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HL670_RS03200	COG0745	RESPONSE REGULATOR receiver
HL670_RS03205	COG0642	Histidine kinase
HL670_RS03210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HL670_RS03220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL670_RS03230	COG1489	DNA binding
HL670_RS03235	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HL670_RS03240	COG1643	Atp-dependent helicase
HL670_RS03245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HL670_RS03250	COG4774	siderophore transport
HL670_RS03255	COG1120	ATPase activity
HL670_RS03260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HL670_RS03265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL670_RS03275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL670_RS03285	COG1166	arginine decarboxylase activity
HL670_RS03295	COG0010	Belongs to the arginase family
HL670_RS03300	COG1187	pseudouridine synthase activity
HL670_RS03305	COG2146	nitrite reductase [NAD(P)H] activity
HL670_RS03325	COG1414	Transcriptional regulator
HL670_RS03340	COG2271	Major facilitator Superfamily
HL670_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS03360	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HL670_RS03375	COG0501	Belongs to the peptidase M48B family
HL670_RS03380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HL670_RS03390	COG1175	transmembrane transport
HL670_RS03395	COG3842	ATPase activity
HL670_RS03400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL670_RS03405	COG0126	phosphoglycerate kinase activity
HL670_RS03410	COG0191	fructose-bisphosphate aldolase activity
HL670_RS03425	COG3122	Protein conserved in bacteria
HL670_RS03435	COG0235	Class ii aldolase
HL670_RS03440	COG3623	hexulose-6-phosphate isomerase
HL670_RS03445	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HL670_RS03450	COG1070	Carbohydrate kinase
HL670_RS03460	COG2731	YhcH YjgK YiaL family protein
HL670_RS03480	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS03485	COG1129	ABC transporter
HL670_RS03490	COG1414	Transcriptional regulator
HL670_RS03495	COG1279	arginine transmembrane transporter activity
HL670_RS03505	COG0583	DNA-binding transcription factor activity
HL670_RS03510	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HL670_RS03515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL670_RS03520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HL670_RS03530	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HL670_RS03535	COG3079	Belongs to the UPF0149 family
HL670_RS03540	COG0006	proline dipeptidase activity
HL670_RS03545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL670_RS03550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL670_RS03565	COG1509	lysine 2,3-aminomutase activity
HL670_RS03570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL670_RS03575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HL670_RS03580	COG0509	glycine decarboxylation via glycine cleavage system
HL670_RS03585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL670_RS03585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL670_RS03610	COG3713	MltA-interacting MipA family protein
HL670_RS03655	COG1272	protein, Hemolysin III
HL670_RS03665	COG0354	folic acid binding
HL670_RS03670	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HL670_RS03680	COG0745	RESPONSE REGULATOR receiver
HL670_RS03685	COG2205	protein histidine kinase activity
HL670_RS03690	COG4452	Inner membrane protein CreD
HL670_RS03695	COG0716	FMN binding
HL670_RS03700	COG4974	Belongs to the 'phage' integrase family
HL670_RS03705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL670_RS03720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HL670_RS03730	COG0582	viral genome integration into host DNA
HL670_RS03745	COG3561	AntA/AntB antirepressor
HL670_RS03805	COG0741	lytic transglycosylase activity
HL670_RS03875	COG1278	Cold shock
HL670_RS03885	COG0484	heat shock protein binding
HL670_RS03890	COG3247	response to pH
HL670_RS03895	COG4942	peptidase
HL670_RS03915	COG5265	(ABC) transporter
HL670_RS03920	COG1942	4-Oxalocrotonate Tautomerase
HL670_RS03930	COG1309	transcriptional regulator
HL670_RS03935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL670_RS03940	COG1304	FMN binding
HL670_RS03945	COG0583	DNA-binding transcription factor activity
HL670_RS03970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS03980	COG1538	Outer membrane efflux protein
HL670_RS03985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL670_RS03990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL670_RS03995	COG0582	viral genome integration into host DNA
HL670_RS04000	COG3539	Fimbrial protein
HL670_RS04005	COG3121	Chaperone
HL670_RS04020	COG3539	Fimbrial protein
HL670_RS04025	COG2197	response regulator
HL670_RS04030	COG2197	response regulator
HL670_RS04035	COG0582	viral genome integration into host DNA
HL670_RS04040	COG4615	Cyclic peptide transporter
HL670_RS04055	COG2807	transmembrane transport
HL670_RS04060	COG4178	(ABC) transporter
HL670_RS04080	COG0583	DNA-binding transcription factor activity
HL670_RS04085	COG2814	Major facilitator Superfamily
HL670_RS04090	COG0583	DNA-binding transcription factor activity
HL670_RS04100	COG1609	Transcriptional regulator
HL670_RS04110	COG1609	Transcriptional regulator
HL670_RS04120	COG0204	Acyl-transferase
HL670_RS04120	COG0318	PFAM AMP-dependent synthetase and ligase
HL670_RS04125	COG0477	Major facilitator Superfamily
HL670_RS04130	COG0667	Aldo Keto reductase
HL670_RS04140	COG0861	Integral membrane protein TerC family
HL670_RS04145	COG3066	DNA modification
HL670_RS04150	COG0494	nUDIX hydrolase
HL670_RS04160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HL670_RS04165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HL670_RS04195	COG1025	Belongs to the peptidase M16 family
HL670_RS04200	COG1074	ATP-dependent DNA helicase activity
HL670_RS04205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HL670_RS04210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HL670_RS04210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL670_RS04215	COG0860	N-Acetylmuramoyl-L-alanine amidase
HL670_RS04235	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HL670_RS04240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HL670_RS04245	COG2166	iron-sulfur cluster assembly
HL670_RS04250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL670_RS04260	COG0583	DNA-binding transcription factor activity
HL670_RS04265	COG2363	Small membrane protein
HL670_RS04270	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HL670_RS04275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL670_RS04280	COG1611	Belongs to the LOG family
HL670_RS04300	COG2814	Major facilitator Superfamily
HL670_RS04305	COG3098	single-species biofilm formation
HL670_RS04310	COG0564	pseudouridine synthase activity
HL670_RS04330	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HL670_RS04340	COG0052	Belongs to the universal ribosomal protein uS2 family
HL670_RS04345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HL670_RS04350	COG0528	UMP kinase activity
HL670_RS04355	COG0233	cytoplasmic translational termination
HL670_RS04360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HL670_RS04365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL670_RS04370	COG0575	Belongs to the CDS family
HL670_RS04375	COG0750	zinc metalloprotease
HL670_RS04380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL670_RS04385	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HL670_RS04390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL670_RS04395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL670_RS04400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL670_RS04405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL670_RS04410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HL670_RS04420	COG0825	malonyl-CoA metabolic process
HL670_RS04430	COG0346	lactoylglutathione lyase activity
HL670_RS04435	COG0037	tRNA processing
HL670_RS04445	COG4568	rho-dependent transcription termination
HL670_RS04460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HL670_RS04465	COG3015	lipoprotein NlpE involved in copper resistance
HL670_RS04470	COG0442	prolyl-tRNA aminoacylation
HL670_RS04475	COG1720	tRNA m6t6A37 methyltransferase activity
HL670_RS04500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HL670_RS04535	COG5544	Lipoprotein
HL670_RS04540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HL670_RS04545	COG1042	CoA-binding domain protein
HL670_RS04545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL670_RS04545	COG0045	succinate-CoA ligase (ADP-forming) activity
HL670_RS04555	COG3118	belongs to the thioredoxin family
HL670_RS04560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL670_RS04565	COG2814	Major facilitator Superfamily
HL670_RS04570	COG1566	PFAM secretion protein HlyD family protein
HL670_RS04580	COG1846	Transcriptional regulator
HL670_RS04590	COG2814	Major facilitator Superfamily
HL670_RS04595	COG0583	DNA-binding transcription factor activity
HL670_RS04600	COG2113	Glycine betaine
HL670_RS04605	COG4176	ABC-type proline glycine betaine transport system permease component
HL670_RS04610	COG4175	Glycine betaine
HL670_RS04625	COG3493	citrate carrier protein
HL670_RS04635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HL670_RS04645	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS04675	COG1780	Probably involved in ribonucleotide reductase function
HL670_RS04680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HL670_RS04685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL670_RS04695	COG4575	ribosome binding
HL670_RS04700	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HL670_RS04715	COG0477	Major facilitator Superfamily
HL670_RS04720	COG0583	DNA-binding transcription factor activity
HL670_RS04735	COG0477	Major facilitator Superfamily
HL670_RS04755	COG2259	Doxx family
HL670_RS04760	COG2388	GCN5-related N-acetyl-transferase
HL670_RS04770	COG2226	methyltransferase
HL670_RS04785	COG3713	MltA-interacting MipA family protein
HL670_RS04790	COG0667	Aldo Keto reductase
HL670_RS04795	COG0583	DNA-binding transcription factor activity
HL670_RS04815	COG0058	SHG alpha-glucan phosphorylase activity
HL670_RS04825	COG2205	protein histidine kinase activity
HL670_RS04825	COG0745	RESPONSE REGULATOR receiver
HL670_RS04825	COG3292	Two component regulator propeller
HL670_RS04840	COG5001	Diguanylate cyclase
HL670_RS04840	COG3447	MASE1 domain protein
HL670_RS04840	COG5002	protein histidine kinase activity
HL670_RS04850	COG3250	beta-galactosidase activity
HL670_RS04900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HL670_RS04905	COG2867	negative regulation of translational initiation
HL670_RS04910	COG2914	Belongs to the UPF0125 (RnfH) family
HL670_RS04915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL670_RS04920	COG0497	DNA recombination
HL670_RS04925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HL670_RS04930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL670_RS04935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HL670_RS04940	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HL670_RS04955	COG0513	Belongs to the DEAD box helicase family
HL670_RS04960	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HL670_RS04985	COG3086	response to oxidative stress
HL670_RS04995	COG0481	GTPase activity
HL670_RS05000	COG0681	Belongs to the peptidase S26 family
HL670_RS05005	COG0571	ribonuclease III activity
HL670_RS05010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HL670_RS05015	COG1381	Involved in DNA repair and RecF pathway recombination
HL670_RS05020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HL670_RS05025	COG0736	holo-[acyl-carrier-protein] synthase activity
HL670_RS05030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL670_RS05035	COG1737	Transcriptional regulator
HL670_RS05040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HL670_RS05045	COG1263	PTS System
HL670_RS05045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL670_RS05050	COG0560	Phosphoserine phosphatase
HL670_RS05065	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HL670_RS05075	COG2205	protein histidine kinase activity
HL670_RS05080	COG3170	Tfp pilus assembly protein FimV
HL670_RS05085	COG2204	response regulator
HL670_RS05090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL670_RS05090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HL670_RS05095	COG0347	Belongs to the P(II) protein family
HL670_RS05110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HL670_RS05115	COG3842	ATPase activity
HL670_RS05125	COG1177	transmembrane transport
HL670_RS05130	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS05135	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HL670_RS05145	COG1017	nitric oxide dioxygenase activity
HL670_RS05145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL670_RS05150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HL670_RS05155	COG2814	Major facilitator Superfamily
HL670_RS05160	COG3711	transcriptional antiterminator
HL670_RS05165	COG3683	transport system, periplasmic component
HL670_RS05170	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HL670_RS05185	COG1959	2 iron, 2 sulfur cluster binding
HL670_RS05190	COG1104	cysteine desulfurase activity
HL670_RS05195	COG0822	iron-sulfur transferase activity
HL670_RS05200	COG0316	Belongs to the HesB IscA family
HL670_RS05205	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HL670_RS05210	COG0443	Heat shock 70 kDa protein
HL670_RS05215	COG0633	Ferredoxin
HL670_RS05220	COG2975	iron-sulfur cluster assembly
HL670_RS05225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HL670_RS05235	COG2373	Large extracellular alpha-helical protein
HL670_RS05240	COG4953	penicillin-binding protein 1C
HL670_RS05245	COG0105	UTP biosynthetic process
HL670_RS05250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HL670_RS05260	COG1426	Protein conserved in bacteria
HL670_RS05265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HL670_RS05270	COG0124	histidyl-tRNA synthetase
HL670_RS05275	COG2976	Protein conserved in bacteria
HL670_RS05280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL670_RS05285	COG1160	GTP binding
HL670_RS05310	COG1609	Transcriptional regulator
HL670_RS05315	COG2271	Major facilitator Superfamily
HL670_RS05325	COG1570	exodeoxyribonuclease VII activity
HL670_RS05330	COG0517	IMP dehydrogenase activity
HL670_RS05330	COG0516	GMP reductase activity
HL670_RS05335	COG0519	Catalyzes the synthesis of GMP from XMP
HL670_RS05335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HL670_RS05345	COG1733	regulation of RNA biosynthetic process
HL670_RS05355	COG0784	Response regulator, receiver
HL670_RS05355	COG2198	Histidine kinase
HL670_RS05355	COG2205	protein histidine kinase activity
HL670_RS05360	COG2197	response regulator
HL670_RS05395	COG2814	Major facilitator Superfamily
HL670_RS05410	COG0456	acetyltransferase
HL670_RS05415	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HL670_RS05420	COG0351	phosphomethylpyrimidine kinase
HL670_RS05435	COG1349	DNA-binding transcription factor activity
HL670_RS05440	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL670_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS05460	COG3730	PTS system glucitol sorbitol-specific
HL670_RS05465	COG1830	Aldolase
HL670_RS05470	COG1802	Transcriptional regulator
HL670_RS05480	COG0246	Mannitol dehydrogenase
HL670_RS05485	COG2271	Major facilitator Superfamily
HL670_RS05490	COG1063	alcohol dehydrogenase
HL670_RS05495	COG4948	Mandelate Racemase Muconate Lactonizing
HL670_RS05500	COG1597	lipid kinase activity
HL670_RS05510	COG3422	double-strand break repair
HL670_RS05520	COG0745	RESPONSE REGULATOR receiver
HL670_RS05525	COG2205	protein histidine kinase activity
HL670_RS05530	COG2814	Major facilitator Superfamily
HL670_RS05535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL670_RS05540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL670_RS05545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS05550	COG0667	Aldo Keto reductase
HL670_RS05560	COG2046	Belongs to the sulfate adenylyltransferase family
HL670_RS05560	COG0529	Catalyzes the synthesis of activated sulfate
HL670_RS05570	COG0443	Heat shock 70 kDa protein
HL670_RS05575	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HL670_RS05585	COG5001	Diguanylate cyclase
HL670_RS05585	COG5002	protein histidine kinase activity
HL670_RS05585	COG3447	MASE1 domain protein
HL670_RS05590	COG2239	Acts as a magnesium transporter
HL670_RS05605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HL670_RS05610	COG0573	inorganic phosphate transmembrane transporter activity
HL670_RS05615	COG0573	inorganic phosphate transmembrane transporter activity
HL670_RS05690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL670_RS05695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HL670_RS05700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HL670_RS05705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HL670_RS05710	COG2233	PERMEase
HL670_RS05715	COG2261	transglycosylase associated protein
HL670_RS05725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HL670_RS05730	COG1393	Belongs to the ArsC family
HL670_RS05735	COG4783	chaperone-mediated protein folding
HL670_RS05770	COG0243	molybdopterin cofactor binding
HL670_RS05775	COG0542	response to heat
HL670_RS05780	COG2837	iron assimilation
HL670_RS05785	COG1271	oxidase subunit
HL670_RS05790	COG1294	oxidase, subunit
HL670_RS05805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HL670_RS05810	COG0314	molybdopterin synthase activity
HL670_RS05815	COG3781	membrane
HL670_RS05820	COG0628	permease
HL670_RS05825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HL670_RS05830	COG2716	regulation of RNA biosynthetic process
HL670_RS05835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL670_RS05840	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HL670_RS05845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HL670_RS05850	COG2321	neutral zinc metallopeptidase
HL670_RS05860	COG0400	carboxylic ester hydrolase activity
HL670_RS05885	COG1876	peptidase activity
HL670_RS05890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL670_RS05895	COG1393	Belongs to the ArsC family
HL670_RS05910	COG0456	acetyltransferase
HL670_RS05940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL670_RS05950	COG2197	response regulator
HL670_RS05955	COG3850	Histidine kinase
HL670_RS05960	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL670_RS05960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL670_RS05965	COG3062	negative regulation of establishment of protein localization
HL670_RS05970	COG0243	molybdopterin cofactor binding
HL670_RS05975	COG3043	anaerobic respiration
HL670_RS05980	COG3005	denitrification pathway
HL670_RS05985	COG0494	nUDIX hydrolase
HL670_RS05995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HL670_RS06000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL670_RS06005	COG3397	chitin binding
HL670_RS06010	COG0583	DNA-binding transcription factor activity
HL670_RS06045	COG2040	homocysteine
HL670_RS06050	COG0833	amino acid
HL670_RS06060	COG1671	Belongs to the UPF0178 family
HL670_RS06065	COG0408	coproporphyrinogen oxidase activity
HL670_RS06075	COG0456	acetyltransferase
HL670_RS06080	COG3111	PFAM Bacterial OB fold (BOF) protein
HL670_RS06095	COG2837	iron assimilation
HL670_RS06100	COG4150	thiosulfate binding
HL670_RS06105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HL670_RS06110	COG4208	sulfate ABC transporter
HL670_RS06120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HL670_RS06130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS06135	COG0745	RESPONSE REGULATOR receiver
HL670_RS06140	COG2205	protein histidine kinase activity
HL670_RS06150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL670_RS06155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL670_RS06165	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HL670_RS06170	COG3115	cell septum assembly
HL670_RS06175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL670_RS06180	COG3530	Putative quorum-sensing-regulated virulence factor
HL670_RS06185	COG0385	Bile acid
HL670_RS06190	COG0583	DNA-binding transcription factor activity
HL670_RS06205	COG4303	Ethanolamine ammonia lyase large subunit
HL670_RS06210	COG4302	ethanolamine ammonia-lyase activity
HL670_RS06230	COG0747	negative chemotaxis
HL670_RS06235	COG4771	TonB-dependent receptor
HL670_RS06240	COG2382	esterase
HL670_RS06245	COG3251	PFAM MbtH domain protein
HL670_RS06255	COG1120	ATPase activity
HL670_RS06260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL670_RS06265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL670_RS06275	COG4592	Periplasmic binding protein
HL670_RS06280	COG1169	isochorismate synthase
HL670_RS06290	COG3433	isochorismatase activity
HL670_RS06290	COG1535	isochorismatase
HL670_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS06325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL670_RS06340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL670_RS06345	COG1914	H( )-stimulated, divalent metal cation uptake system
HL670_RS06355	COG0667	Aldo Keto reductase
HL670_RS06360	COG3961	Belongs to the TPP enzyme family
HL670_RS06375	COG1794	racemase activity, acting on amino acids and derivatives
HL670_RS06390	COG2223	nitrite transmembrane transporter activity
HL670_RS06400	COG3279	Response regulator of the LytR AlgR family
HL670_RS06405	COG3275	phosphorelay sensor kinase activity
HL670_RS06420	COG0436	Aminotransferase
HL670_RS06425	COG3038	cytochrome b561
HL670_RS06435	COG1598	PFAM Uncharacterised protein family UPF0150
HL670_RS06445	COG2951	lytic endotransglycosylase activity
HL670_RS06465	COG0697	spore germination
HL670_RS06475	COG0583	DNA-binding transcription factor activity
HL670_RS06485	COG2116	formate transmembrane transporter activity
HL670_RS06495	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL670_RS06500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL670_RS06505	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL670_RS06510	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HL670_RS06515	COG1138	Cytochrome C-type biogenesis protein
HL670_RS06520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HL670_RS06525	COG3088	subunit of a heme lyase
HL670_RS06525	COG4235	cytochrome complex assembly
HL670_RS06530	COG3088	subunit of a heme lyase
HL670_RS06530	COG4235	cytochrome complex assembly
HL670_RS06545	COG3691	Protein conserved in bacteria
HL670_RS06550	COG0183	Belongs to the thiolase family
HL670_RS06555	COG1024	Enoyl-CoA hydratase
HL670_RS06555	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL670_RS06560	COG2062	phosphohistidine phosphatase, SixA
HL670_RS06565	COG2840	Smr protein MutS2
HL670_RS06570	COG2890	protein-(glutamine-N5) methyltransferase activity
HL670_RS06575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HL670_RS06580	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HL670_RS06585	COG0730	response to heat
HL670_RS06590	COG3101	peptidyl-lysine hydroxylation
HL670_RS06600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL670_RS06600	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HL670_RS06605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL670_RS06630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS06640	COG1477	protein flavinylation
HL670_RS06645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HL670_RS06650	COG2195	Cleaves the N-terminal amino acid of tripeptides
HL670_RS06695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HL670_RS06700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL670_RS06735	COG0642	Histidine kinase
HL670_RS06740	COG0697	spore germination
HL670_RS06750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL670_RS06755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HL670_RS06765	COG0586	Pfam SNARE associated Golgi protein
HL670_RS06770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HL670_RS06775	COG0285	dihydrofolate synthase activity
HL670_RS06780	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HL670_RS06785	COG1286	toxin biosynthetic process
HL670_RS06790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HL670_RS06795	COG0163	prenyltransferase activity
HL670_RS06800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL670_RS06805	COG4215	(ABC) transporter
HL670_RS06820	COG1090	epimerase
HL670_RS06825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HL670_RS06830	COG0625	glutathione transferase activity
HL670_RS06840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HL670_RS06845	COG0280	phosphate acetyltransferase
HL670_RS06845	COG0857	belongs to the CobB CobQ family
HL670_RS06850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HL670_RS06855	COG3092	negative regulation of chromosome organization
HL670_RS06860	COG3013	Belongs to the UPF0304 family
HL670_RS06865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL670_RS06870	COG0490	domain, Protein
HL670_RS06870	COG0471	metal ion transport
HL670_RS06875	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HL670_RS06880	COG0436	Aminotransferase
HL670_RS06890	COG0583	DNA-binding transcription factor activity
HL670_RS06895	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL670_RS06900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL670_RS06905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL670_RS06905	COG0649	NAD binding
HL670_RS06920	COG1034	ATP synthesis coupled electron transport
HL670_RS06925	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL670_RS06935	COG0839	Belongs to the complex I subunit 6 family
HL670_RS06940	COG0713	ATP synthesis coupled electron transport
HL670_RS06945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HL670_RS06950	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL670_RS06955	COG1007	ATP synthesis coupled electron transport
HL670_RS06965	COG0028	Belongs to the TPP enzyme family
HL670_RS06995	COG1609	Transcriptional regulator
HL670_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS07005	COG1063	alcohol dehydrogenase
HL670_RS07010	COG4575	ribosome binding
HL670_RS07020	COG1169	isochorismate synthase
HL670_RS07025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HL670_RS07030	COG0596	Alpha beta hydrolase
HL670_RS07035	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HL670_RS07060	COG0814	amino acid
HL670_RS07075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL670_RS07085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL670_RS07090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HL670_RS07100	COG0784	Response regulator, receiver
HL670_RS07100	COG2205	protein histidine kinase activity
HL670_RS07110	COG2198	Histidine kinase
HL670_RS07110	COG0642	Histidine kinase
HL670_RS07115	COG2223	nitrite transmembrane transporter activity
HL670_RS07135	COG0346	lactoylglutathione lyase activity
HL670_RS07160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL670_RS07190	COG3082	Protein of unknown function (DUF1414)
HL670_RS07200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HL670_RS07205	COG1061	Type III restriction enzyme res subunit
HL670_RS07210	COG1187	pseudouridine synthase activity
HL670_RS07215	COG2814	Major facilitator Superfamily
HL670_RS07225	COG4172	Belongs to the ABC transporter superfamily
HL670_RS07230	COG4239	(ABC) transporter, permease
HL670_RS07235	COG4174	ABC transporter (Permease)
HL670_RS07240	COG4166	transmembrane transport
HL670_RS07250	COG0791	NLP P60 protein
HL670_RS07255	COG0671	phosphoesterase, PA-phosphatase related
HL670_RS07260	COG0523	cobalamin synthesis protein
HL670_RS07270	COG0246	Mannitol dehydrogenase
HL670_RS07275	COG1312	Catalyzes the dehydration of D-mannonate
HL670_RS07280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HL670_RS07300	COG0243	molybdopterin cofactor binding
HL670_RS07305	COG3005	denitrification pathway
HL670_RS07310	COG0494	nUDIX hydrolase
HL670_RS07320	COG1105	Belongs to the carbohydrate kinase PfkB family
HL670_RS07325	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HL670_RS07325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL670_RS07325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL670_RS07330	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HL670_RS07335	COG2855	membrane
HL670_RS07340	COG0583	DNA-binding transcription factor activity
HL670_RS07345	COG0833	amino acid
HL670_RS07350	COG3706	GGDEF domain
HL670_RS07355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL670_RS07360	COG1120	ATPase activity
HL670_RS07375	COG1129	ABC transporter
HL670_RS07385	COG1396	sequence-specific DNA binding
HL670_RS07385	COG1917	Cupin 2, conserved barrel domain protein
HL670_RS07390	COG0174	glutamine synthetase
HL670_RS07395	COG0531	amino acid
HL670_RS07400	COG2925	Exonuclease
HL670_RS07425	COG3023	N-Acetylmuramoyl-L-alanine amidase
HL670_RS07430	COG1289	transmembrane transporter activity
HL670_RS07435	COG2926	Belongs to the UPF0265 family
HL670_RS07440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL670_RS07445	COG1473	amidohydrolase
HL670_RS07490	COG1174	glycine betaine transport
HL670_RS07505	COG2986	histidine ammonia-lyase
HL670_RS07540	COG3414	Phosphotransferase system galactitol-specific IIB component
HL670_RS07545	COG3775	system Galactitol-specific IIC component
HL670_RS07550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL670_RS07560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HL670_RS07570	COG1129	ABC transporter
HL670_RS07575	COG1879	ABC-type sugar transport system periplasmic component
HL670_RS07580	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS07585	COG1070	Carbohydrate kinase
HL670_RS07605	COG0559	Belongs to the binding-protein-dependent transport system permease family
HL670_RS07635	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL670_RS07640	COG2207	Transcriptional regulator
HL670_RS07645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HL670_RS07650	COG3477	response to acidic pH
HL670_RS07660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HL670_RS07665	COG0022	dehydrogenase e1 component
HL670_RS07675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL670_RS07680	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS07695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HL670_RS07755	COG0277	FAD linked oxidase domain protein
HL670_RS07760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL670_RS07780	COG0251	oxidation-reduction process
HL670_RS07785	COG0402	S-adenosylhomocysteine deaminase activity
HL670_RS07795	COG0583	DNA-binding transcription factor activity
HL670_RS07825	COG4565	transcriptional regulatory protein
HL670_RS07830	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HL670_RS07835	COG3052	prosthetic group binding
HL670_RS07840	COG2301	Belongs to the HpcH HpaI aldolase family
HL670_RS07845	COG3051	citrate lyase alpha subunit
HL670_RS07860	COG0471	metal ion transport
HL670_RS07880	COG2977	Belongs to the P-Pant transferase superfamily
HL670_RS07900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HL670_RS07905	COG1063	alcohol dehydrogenase
HL670_RS07910	COG2271	Major facilitator Superfamily
HL670_RS07915	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS07925	COG2186	Transcriptional regulator
HL670_RS07945	COG0601	transmembrane transport
HL670_RS07950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL670_RS07955	COG4172	Belongs to the ABC transporter superfamily
HL670_RS07960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS07975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS07990	COG0859	PFAM glycosyl transferase family 9
HL670_RS08000	COG0583	DNA-binding transcription factor activity
HL670_RS08020	COG3238	Protein conserved in bacteria
HL670_RS08055	COG0436	Aminotransferase
HL670_RS08070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HL670_RS08080	COG0436	Aminotransferase
HL670_RS08120	COG4774	siderophore transport
HL670_RS08155	COG0583	DNA-binding transcription factor activity
HL670_RS08160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL670_RS08170	COG0583	DNA-binding transcription factor activity
HL670_RS08190	COG2207	Transcriptional regulator
HL670_RS08195	COG1881	PFAM PEBP family protein
HL670_RS08215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS08220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL670_RS08265	COG0583	DNA-binding transcription factor activity
HL670_RS08270	COG1902	pentaerythritol trinitrate reductase activity
HL670_RS08285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HL670_RS08330	COG1301	dicarboxylic acid transport
HL670_RS08340	COG0583	DNA-binding transcription factor activity
HL670_RS08345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL670_RS08355	COG0702	epimerase
HL670_RS08360	COG0702	epimerase
HL670_RS08375	COG0398	Pfam SNARE associated Golgi protein
HL670_RS08380	COG1309	transcriptional regulator
HL670_RS08385	COG1309	transcriptional regulator
HL670_RS08390	COG1902	pentaerythritol trinitrate reductase activity
HL670_RS08395	COG4221	oxidoreductase activity
HL670_RS08415	COG1733	regulation of RNA biosynthetic process
HL670_RS08445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HL670_RS08450	COG0732	type I restriction modification DNA specificity domain
HL670_RS08455	COG0419	ATPase involved in DNA repair
HL670_RS08495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL670_RS08510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HL670_RS08520	COG0386	Belongs to the glutathione peroxidase family
HL670_RS08530	COG4227	nucleotidyltransferase activity
HL670_RS08635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HL670_RS08675	COG1733	regulation of RNA biosynthetic process
HL670_RS08680	COG4221	oxidoreductase activity
HL670_RS08685	COG4221	oxidoreductase activity
HL670_RS08695	COG2207	Transcriptional regulator
HL670_RS08705	COG0667	Aldo Keto reductase
HL670_RS08720	COG0656	L-ascorbic acid biosynthetic process
HL670_RS08735	COG2814	Major facilitator Superfamily
HL670_RS08740	COG0582	viral genome integration into host DNA
HL670_RS08755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HL670_RS08770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL670_RS08775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL670_RS08780	COG1116	anion transmembrane transporter activity
HL670_RS08785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HL670_RS08790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS08800	COG4977	sequence-specific DNA binding
HL670_RS08805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL670_RS08815	COG3842	ATPase activity
HL670_RS08825	COG1840	ABC-type Fe3 transport system, periplasmic component
HL670_RS08830	COG1609	Transcriptional regulator
HL670_RS08835	COG3284	Transcriptional regulator
HL670_RS08840	COG0095	Lipoate-protein ligase
HL670_RS08845	COG1063	alcohol dehydrogenase
HL670_RS08890	COG0583	DNA-binding transcription factor activity
HL670_RS08925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL670_RS08930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL670_RS08930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HL670_RS08945	COG2986	histidine ammonia-lyase
HL670_RS08955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS08960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS08990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS09015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HL670_RS09025	COG3228	Belongs to the MtfA family
HL670_RS09055	COG0673	inositol 2-dehydrogenase activity
HL670_RS09075	COG0534	Mate efflux family protein
HL670_RS09085	COG1486	melibiose metabolic process
HL670_RS09090	COG2223	nitrite transmembrane transporter activity
HL670_RS09100	COG4993	Dehydrogenase
HL670_RS09135	COG1914	H( )-stimulated, divalent metal cation uptake system
HL670_RS09150	COG0625	glutathione transferase activity
HL670_RS09155	COG0583	DNA-binding transcription factor activity
HL670_RS09175	COG1113	amino acid transport
HL670_RS09180	COG0697	spore germination
HL670_RS09190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HL670_RS09195	COG3327	negative regulation of DNA-templated transcription, initiation
HL670_RS09200	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL670_RS09205	COG2050	protein possibly involved in aromatic compounds catabolism
HL670_RS09210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL670_RS09215	COG1024	Enoyl-CoA hydratase
HL670_RS09220	COG1024	Enoyl-CoA hydratase
HL670_RS09225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL670_RS09230	COG2151	metal-sulfur cluster biosynthetic enzyme
HL670_RS09235	COG3396	Phenylacetate-CoA oxygenase
HL670_RS09240	COG3460	Phenylacetate-CoA oxygenase
HL670_RS09245	COG3396	Phenylacetate-CoA oxygenase
HL670_RS09255	COG2203	Gaf domain
HL670_RS09255	COG3706	GGDEF domain
HL670_RS09255	COG4251	negative regulation of phosphorylation
HL670_RS09255	COG5001	Diguanylate cyclase
HL670_RS09265	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HL670_RS09270	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS09275	COG0583	DNA-binding transcription factor activity
HL670_RS09285	COG2261	transglycosylase associated protein
HL670_RS09290	COG3753	Protein conserved in bacteria
HL670_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS09310	COG0604	alcohol dehydrogenase
HL670_RS09310	COG3321	synthase
HL670_RS09355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HL670_RS09365	COG1285	pathogenesis
HL670_RS09415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HL670_RS09420	COG1393	Belongs to the ArsC family
HL670_RS09430	COG0183	Belongs to the thiolase family
HL670_RS09445	COG1414	Transcriptional regulator
HL670_RS09500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HL670_RS09505	COG1609	Transcriptional regulator
HL670_RS09510	COG2211	Major facilitator Superfamily
HL670_RS09525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL670_RS09555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL670_RS09565	COG3483	tryptophan 2,3-dioxygenase activity
HL670_RS09570	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HL670_RS09610	COG0643	Histidine kinase
HL670_RS09610	COG2198	Histidine kinase
HL670_RS09615	COG0835	chemotaxis
HL670_RS09625	COG0840	transmembrane signaling receptor activity
HL670_RS09630	COG0840	transmembrane signaling receptor activity
HL670_RS09635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HL670_RS09640	COG2201	protein-glutamate methylesterase activity
HL670_RS09645	COG0745	RESPONSE REGULATOR receiver
HL670_RS09650	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HL670_RS09655	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL670_RS09660	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL670_RS09675	COG3418	PFAM FlgN family protein
HL670_RS09680	COG2747	anti-sigma28 factor FlgM
HL670_RS09690	COG1815	bacterial-type flagellum-dependent cell motility
HL670_RS09695	COG1558	bacterial-type flagellum-dependent cell motility
HL670_RS09700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HL670_RS09705	COG1749	Flagellar hook protein flgE
HL670_RS09715	COG4786	Flagellar basal body rod
HL670_RS09735	COG1256	bacterial-type flagellum assembly
HL670_RS09780	COG1580	Controls the rotational direction of flagella during chemotaxis
HL670_RS09785	COG3144	bacterial-type flagellum assembly
HL670_RS09790	COG2882	bacterial-type flagellum organization
HL670_RS09795	COG1157	protein secretion by the type III secretion system
HL670_RS09800	COG1317	bacterial-type flagellum organization
HL670_RS09805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL670_RS09815	COG1677	Flagellar hook-basal body complex protein FliE
HL670_RS09855	COG1191	sigma factor activity
HL670_RS09865	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HL670_RS09895	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HL670_RS09895	COG0506	proline dehydrogenase activity
HL670_RS09895	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HL670_RS09910	COG0672	)-iron permease
HL670_RS09925	COG4772	TonB-dependent receptor
HL670_RS09930	COG1702	phosphate starvation-inducible protein PhoH
HL670_RS09940	COG0387	Pfam Sodium calcium exchanger
HL670_RS09945	COG2375	cellular response to nickel ion
HL670_RS09950	COG4572	Cation transport regulator
HL670_RS09955	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HL670_RS09960	COG0583	DNA-binding transcription factor activity
HL670_RS09965	COG4166	transmembrane transport
HL670_RS09970	COG0601	transmembrane transport
HL670_RS09975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL670_RS09980	COG0444	Belongs to the ABC transporter superfamily
HL670_RS09985	COG4608	Belongs to the ABC transporter superfamily
HL670_RS09995	COG3707	response regulator
HL670_RS10000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL670_RS10010	COG1116	anion transmembrane transporter activity
HL670_RS10015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HL670_RS10015	COG2146	nitrite reductase [NAD(P)H] activity
HL670_RS10020	COG0243	molybdopterin cofactor binding
HL670_RS10025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HL670_RS10025	COG1648	precorrin-2 dehydrogenase activity
HL670_RS10040	COG4932	domain protein
HL670_RS10045	COG2197	response regulator
HL670_RS10050	COG3850	Histidine kinase
HL670_RS10060	COG3710	Transcriptional regulator
HL670_RS10065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL670_RS10070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL670_RS10095	COG0463	Glycosyl transferase, family 2
HL670_RS10105	COG1215	transferase activity, transferring glycosyl groups
HL670_RS10115	COG1216	Glycosyl transferase, family 2
HL670_RS10120	COG1216	Glycosyl transferase, family 2
HL670_RS10120	COG0463	Glycosyl transferase, family 2
HL670_RS10130	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HL670_RS10135	COG1140	nitrate reductase beta subunit
HL670_RS10140	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HL670_RS10145	COG2181	nitrate reductase activity
HL670_RS10150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL670_RS10155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL670_RS10205	COG1294	oxidase, subunit
HL670_RS10210	COG1271	oxidase subunit
HL670_RS10215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL670_RS10225	COG0601	transmembrane transport
HL670_RS10235	COG0444	Belongs to the ABC transporter superfamily
HL670_RS10240	COG4608	Belongs to the ABC transporter superfamily
HL670_RS10250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL670_RS10255	COG3138	arginine N-succinyltransferase
HL670_RS10260	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS10265	COG3724	N-succinylarginine dihydrolase activity
HL670_RS10270	COG2988	succinylglutamate desuccinylase activity
HL670_RS10290	COG1652	LysM domain
HL670_RS10315	COG2207	Transcriptional regulator
HL670_RS10390	COG2226	methyltransferase
HL670_RS10395	COG0640	Transcriptional regulator
HL670_RS10405	COG1971	Probably functions as a manganese efflux pump
HL670_RS10410	COG4811	Protein of unknown function (DUF986)
HL670_RS10415	COG3716	PTS system mannose fructose sorbose family IID component
HL670_RS10420	COG3715	PTS system
HL670_RS10425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL670_RS10425	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL670_RS10430	COG1253	flavin adenine dinucleotide binding
HL670_RS10435	COG2200	EAL domain
HL670_RS10440	COG1760	l-serine dehydratase
HL670_RS10445	COG0494	nUDIX hydrolase
HL670_RS10455	COG1216	Glycosyl transferase, family 2
HL670_RS10460	COG3140	Belongs to the UPF0181 family
HL670_RS10465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HL670_RS10470	COG0513	Belongs to the DEAD box helicase family
HL670_RS10475	COG3141	response to X-ray
HL670_RS10500	COG2999	glutathione oxidoreductase activity
HL670_RS10510	COG0477	Major facilitator Superfamily
HL670_RS10515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL670_RS10535	COG0018	arginyl-trna synthetase
HL670_RS10540	COG3102	Protein conserved in bacteria
HL670_RS10545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HL670_RS10550	COG3142	Participates in the control of copper homeostasis
HL670_RS10580	COG0500	methyltransferase
HL670_RS10585	COG2226	methyltransferase
HL670_RS10590	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HL670_RS10595	COG1801	Protein of unknown function DUF72
HL670_RS10600	COG1335	isochorismatase
HL670_RS10610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HL670_RS10615	COG0494	nUDIX hydrolase
HL670_RS10620	COG0217	transcriptional regulatory protein
HL670_RS10625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HL670_RS10630	COG0632	four-way junction helicase activity
HL670_RS10635	COG2255	four-way junction helicase activity
HL670_RS10640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL670_RS10645	COG1121	(ABC) transporter
HL670_RS10650	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HL670_RS10655	COG0739	heme binding
HL670_RS10660	COG1560	Kdo2-lipid A biosynthetic process
HL670_RS10670	COG0469	pyruvate kinase activity
HL670_RS10675	COG1737	Transcriptional regulator
HL670_RS10680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HL670_RS10685	COG0800	Aldolase
HL670_RS10690	COG2076	Multidrug Resistance protein
HL670_RS10695	COG2076	Multidrug Resistance protein
HL670_RS10700	COG0251	oxidation-reduction process
HL670_RS10705	COG1199	ATP-dependent helicase activity
HL670_RS10715	COG3065	identical protein binding
HL670_RS10720	COG0318	PFAM AMP-dependent synthetase and ligase
HL670_RS10725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HL670_RS10730	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HL670_RS10735	COG2894	cell division
HL670_RS10740	COG0850	regulation of cytokinetic process
HL670_RS10745	COG3100	YcgL domain-containing protein
HL670_RS10750	COG2951	lytic endotransglycosylase activity
HL670_RS10755	COG0179	Fumarylacetoacetate (FAA) hydrolase
HL670_RS10765	COG2983	Belongs to the UPF0260 family
HL670_RS10770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HL670_RS10775	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HL670_RS10780	COG2186	Transcriptional regulator
HL670_RS10790	COG2719	SpoVR family
HL670_RS10795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL670_RS10800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HL670_RS10815	COG0601	transmembrane transport
HL670_RS10830	COG0444	Belongs to the ABC transporter superfamily
HL670_RS10855	COG0401	homolog of Blt101
HL670_RS10875	COG2718	Belongs to the UPF0229 family
HL670_RS10880	COG2766	serine protein kinase
HL670_RS10885	COG3713	MltA-interacting MipA family protein
HL670_RS10895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL670_RS10900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL670_RS10905	COG3139	Protein of unknown function (DUF1315)
HL670_RS10915	COG1335	isochorismatase
HL670_RS10920	COG0252	asparaginase activity
HL670_RS10930	COG0778	Nitroreductase
HL670_RS10945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HL670_RS10955	COG0494	nUDIX hydrolase
HL670_RS10960	COG0708	Exodeoxyribonuclease III
HL670_RS10985	COG0788	formyltetrahydrofolate deformylase activity
HL670_RS10990	COG3012	SEC-C Motif Domain Protein
HL670_RS11000	COG0745	RESPONSE REGULATOR receiver
HL670_RS11005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HL670_RS11030	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS11030	COG1454	alcohol dehydrogenase
HL670_RS11035	COG2095	MarC family integral membrane protein
HL670_RS11040	COG4166	transmembrane transport
HL670_RS11055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL670_RS11060	COG0444	Belongs to the ABC transporter superfamily
HL670_RS11070	COG3099	Belongs to the UPF0263 family
HL670_RS11075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HL670_RS11115	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HL670_RS11120	COG2350	Protein conserved in bacteria
HL670_RS11125	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HL670_RS11135	COG1607	acyl-coa hydrolase
HL670_RS11140	COG2917	probably involved in intracellular septation
HL670_RS11155	COG0727	PFAM Uncharacterised protein family (UPF0153)
HL670_RS11160	COG3047	cAMP biosynthetic process
HL670_RS11170	COG0159	tryptophan synthase activity
HL670_RS11175	COG0133	tryptophan synthase activity
HL670_RS11185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL670_RS11200	COG0613	PHP domain protein
HL670_RS11205	COG0009	L-threonylcarbamoyladenylate synthase
HL670_RS11220	COG1187	pseudouridine synthase activity
HL670_RS11225	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HL670_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS11235	COG0616	signal peptide processing
HL670_RS11250	COG0583	DNA-binding transcription factor activity
HL670_RS11260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HL670_RS11270	COG0671	phosphoesterase, PA-phosphatase related
HL670_RS11275	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HL670_RS11280	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HL670_RS11300	COG0023	Translation Initiation Factor
HL670_RS11310	COG0235	Class ii aldolase
HL670_RS11315	COG1349	DNA-binding transcription factor activity
HL670_RS11320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL670_RS11325	COG1966	Carbon starvation protein
HL670_RS11330	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HL670_RS11335	COG0243	molybdopterin cofactor binding
HL670_RS11350	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL670_RS11350	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL670_RS11360	COG4172	Belongs to the ABC transporter superfamily
HL670_RS11365	COG4171	peptide transport system, permease
HL670_RS11370	COG4168	peptide transport system, permease
HL670_RS11380	COG1469	GTP cyclohydrolase I activity
HL670_RS11400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HL670_RS11405	COG1842	Phage shock protein A
HL670_RS11415	COG1983	PspC domain protein
HL670_RS11430	COG3106	COG3106 Predicted ATPase
HL670_RS11435	COG3768	UPF0283 membrane protein
HL670_RS11445	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HL670_RS11450	COG4948	Mandelate Racemase Muconate Lactonizing
HL670_RS11455	COG2866	Carboxypeptidase
HL670_RS11465	COG4166	transmembrane transport
HL670_RS11485	COG0037	tRNA processing
HL670_RS11510	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL670_RS11510	COG1013	pyruvate-flavodoxin oxidoreductase activity
HL670_RS11510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL670_RS11510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HL670_RS11520	COG3042	response to heat
HL670_RS11525	COG3187	Heat shock protein
HL670_RS11530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL670_RS11535	COG2911	Protein conserved in bacteria
HL670_RS11545	COG3784	Protein of unknown function (DUF1318)
HL670_RS11550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HL670_RS11555	COG1643	Atp-dependent helicase
HL670_RS11575	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HL670_RS11580	COG2205	protein histidine kinase activity
HL670_RS11585	COG0745	RESPONSE REGULATOR receiver
HL670_RS11615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HL670_RS11620	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HL670_RS11625	COG0589	response to stress
HL670_RS11635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL670_RS11655	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HL670_RS11680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS11685	COG2755	lipolytic protein G-D-S-L family
HL670_RS11685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL670_RS11700	COG0306	phosphate transporter
HL670_RS11815	COG0697	spore germination
HL670_RS11820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL670_RS11850	COG0642	Histidine kinase
HL670_RS11855	COG0583	DNA-binding transcription factor activity
HL670_RS11870	COG2239	Acts as a magnesium transporter
HL670_RS11920	COG1196	nuclear chromosome segregation
HL670_RS11920	COG3264	Mechanosensitive ion channel
HL670_RS11930	COG2190	(PTS) system
HL670_RS11930	COG1263	PTS System
HL670_RS11930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL670_RS11935	COG0583	DNA-binding transcription factor activity
HL670_RS11940	COG1653	transport
HL670_RS11960	COG3842	ATPase activity
HL670_RS11965	COG0366	Alpha amylase catalytic
HL670_RS11975	COG1129	ABC transporter
HL670_RS11985	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS11995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL670_RS12015	COG2011	ABC-type metal ion transport system permease component
HL670_RS12020	COG2199	diguanylate cyclase activity
HL670_RS12025	COG5507	3-demethylubiquinone-9 3-methyltransferase
HL670_RS12040	COG3048	D-serine ammonia-lyase activity
HL670_RS12045	COG1414	Transcriptional regulator
HL670_RS12065	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HL670_RS12070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL670_RS12080	COG2814	Major facilitator Superfamily
HL670_RS12095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL670_RS12100	COG0583	DNA-binding transcription factor activity
HL670_RS12105	COG3485	protocatechuate 3,4-dioxygenase
HL670_RS12110	COG3485	protocatechuate 3,4-dioxygenase
HL670_RS12120	COG2723	6-phospho-beta-galactosidase activity
HL670_RS12130	COG2271	Major facilitator Superfamily
HL670_RS12135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL670_RS12145	COG1045	serine acetyltransferase
HL670_RS12150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HL670_RS12155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL670_RS12165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL670_RS12170	COG2011	ABC-type metal ion transport system permease component
HL670_RS12205	COG0583	DNA-binding transcription factor activity
HL670_RS12215	COG1396	sequence-specific DNA binding
HL670_RS12220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL670_RS12225	COG3135	benzoate transporter
HL670_RS12250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL670_RS12265	COG0693	protein deglycase activity
HL670_RS12280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HL670_RS12325	COG1733	regulation of RNA biosynthetic process
HL670_RS12330	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL670_RS12335	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL670_RS12340	COG0583	DNA-binding transcription factor activity
HL670_RS12345	COG1082	Xylose isomerase domain protein TIM barrel
HL670_RS12350	COG0673	inositol 2-dehydrogenase activity
HL670_RS12365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL670_RS12385	COG2070	2-Nitropropane dioxygenase
HL670_RS12385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HL670_RS12400	COG3321	synthase
HL670_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS12400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS12400	COG0318	PFAM AMP-dependent synthetase and ligase
HL670_RS12400	COG0300	oxidoreductase activity
HL670_RS12415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS12415	COG0300	oxidoreductase activity
HL670_RS12415	COG3321	synthase
HL670_RS12415	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS12415	COG0318	PFAM AMP-dependent synthetase and ligase
HL670_RS12420	COG3321	synthase
HL670_RS12420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS12420	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS12420	COG4221	oxidoreductase activity
HL670_RS12425	COG4221	oxidoreductase activity
HL670_RS12425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS12425	COG3321	synthase
HL670_RS12430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL670_RS12430	COG3321	synthase
HL670_RS12430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS12430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL670_RS12435	COG3321	synthase
HL670_RS12435	COG4221	oxidoreductase activity
HL670_RS12435	COG0300	oxidoreductase activity
HL670_RS12435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL670_RS12440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS12460	COG2072	flavoprotein involved in K transport
HL670_RS12470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL670_RS12475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL670_RS12480	COG3425	synthase
HL670_RS12485	COG1024	Enoyl-CoA hydratase
HL670_RS12510	COG0702	epimerase
HL670_RS12515	COG1733	regulation of RNA biosynthetic process
HL670_RS12520	COG4221	oxidoreductase activity
HL670_RS12530	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS12540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL670_RS12560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL670_RS12575	COG4580	involved in the transport of maltose and maltodextrins
HL670_RS12580	COG1447	Phosphotransferase system cellobiose-specific component IIA
HL670_RS12585	COG2723	6-phospho-beta-galactosidase activity
HL670_RS12590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL670_RS12590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL670_RS12600	COG1609	Transcriptional regulator
HL670_RS12610	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL670_RS12615	COG3713	MltA-interacting MipA family protein
HL670_RS12625	COG0789	Transcriptional regulator
HL670_RS12630	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL670_RS12630	COG1902	pentaerythritol trinitrate reductase activity
HL670_RS12660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HL670_RS12665	COG0076	glutamate decarboxylase activity
HL670_RS12690	COG0426	domain, Protein
HL670_RS12690	COG1773	rubredoxin
HL670_RS12695	COG3604	Transcriptional regulator
HL670_RS12705	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS12710	COG2207	Transcriptional regulator
HL670_RS12715	COG4993	Dehydrogenase
HL670_RS12765	COG1522	sequence-specific DNA binding
HL670_RS12790	COG0583	DNA-binding transcription factor activity
HL670_RS12810	COG0673	inositol 2-dehydrogenase activity
HL670_RS12825	COG4558	Periplasmic binding protein
HL670_RS12840	COG2862	Uncharacterized protein family, UPF0114
HL670_RS12845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL670_RS12885	COG1874	Beta-galactosidase
HL670_RS12895	COG3833	ABC-type maltose transport systems, permease component
HL670_RS12900	COG1175	transmembrane transport
HL670_RS12905	COG2182	Extracellular solute-binding protein
HL670_RS12915	COG2315	Protein conserved in bacteria
HL670_RS12980	COG1309	transcriptional regulator
HL670_RS12990	COG0371	Dehydrogenase
HL670_RS13010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HL670_RS13015	COG2814	Major facilitator Superfamily
HL670_RS13025	COG2814	Major facilitator Superfamily
HL670_RS13035	COG0583	DNA-binding transcription factor activity
HL670_RS13040	COG2079	MmgE PrpD family protein
HL670_RS13045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS13055	COG0765	amino acid transport
HL670_RS13060	COG1126	abc transporter atp-binding protein
HL670_RS13085	COG0768	penicillin binding
HL670_RS13100	COG0583	DNA-binding transcription factor activity
HL670_RS13115	COG4608	Belongs to the ABC transporter superfamily
HL670_RS13120	COG0444	Belongs to the ABC transporter superfamily
HL670_RS13125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL670_RS13130	COG0601	transmembrane transport
HL670_RS13135	COG0747	negative chemotaxis
HL670_RS13150	COG3153	acetyltransferase
HL670_RS13170	COG1215	transferase activity, transferring glycosyl groups
HL670_RS13175	COG2814	Major facilitator Superfamily
HL670_RS13210	COG0384	phenazine biosynthesis protein PhzF
HL670_RS13220	COG3609	addiction module antidote protein, CC2985 family
HL670_RS13245	COG3711	transcriptional antiterminator
HL670_RS13250	COG2723	6-phospho-beta-galactosidase activity
HL670_RS13255	COG1263	PTS System
HL670_RS13255	COG2190	(PTS) system
HL670_RS13255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL670_RS13275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL670_RS13300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL670_RS13300	COG2010	Cytochrome c
HL670_RS13305	COG2080	2 iron, 2 sulfur cluster binding
HL670_RS13310	COG1846	Transcriptional regulator
HL670_RS13315	COG2309	aminopeptidase activity
HL670_RS13320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL670_RS13325	COG0596	Alpha beta hydrolase
HL670_RS13330	COG3473	Maleate cis-trans isomerase
HL670_RS13335	COG1335	isochorismatase
HL670_RS13340	COG2271	Major facilitator Superfamily
HL670_RS13345	COG0339	signal peptide processing
HL670_RS13355	COG0366	Alpha amylase catalytic
HL670_RS13380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL670_RS13390	COG0402	S-adenosylhomocysteine deaminase activity
HL670_RS13395	COG3469	chitinase activity
HL670_RS13400	COG3397	chitin binding
HL670_RS13405	COG1940	carbohydrate kinase activity
HL670_RS13410	COG2182	Extracellular solute-binding protein
HL670_RS13425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL670_RS13435	COG0477	Major facilitator Superfamily
HL670_RS13440	COG0667	Aldo Keto reductase
HL670_RS13450	COG4221	oxidoreductase activity
HL670_RS13455	COG1742	UPF0060 membrane protein
HL670_RS13480	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HL670_RS13490	COG0583	DNA-binding transcription factor activity
HL670_RS13495	COG2814	Major facilitator Superfamily
HL670_RS13510	COG2378	regulation of single-species biofilm formation
HL670_RS13515	COG0583	DNA-binding transcription factor activity
HL670_RS13525	COG0114	fumarate hydratase activity
HL670_RS13540	COG5339	Protein conserved in bacteria
HL670_RS13550	COG0583	DNA-binding transcription factor activity
HL670_RS13565	COG1609	Transcriptional regulator
HL670_RS13570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL670_RS13570	COG1263	PTS System
HL670_RS13575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HL670_RS13585	COG0494	nUDIX hydrolase
HL670_RS13590	COG1349	DNA-binding transcription factor activity
HL670_RS13595	COG0205	6-phosphofructokinase activity
HL670_RS13630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL670_RS13635	COG0385	Bile acid
HL670_RS13640	COG0673	inositol 2-dehydrogenase activity
HL670_RS13645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HL670_RS13650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HL670_RS13655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL670_RS13670	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS13675	COG1129	ABC transporter
HL670_RS13680	COG1879	ABC-type sugar transport system periplasmic component
HL670_RS13685	COG1069	ribulokinase activity
HL670_RS13690	COG2160	L-arabinose isomerase activity
HL670_RS13700	COG4657	Part of a membrane complex involved in electron transport
HL670_RS13705	COG2878	Part of a membrane complex involved in electron transport
HL670_RS13710	COG4656	Part of a membrane complex involved in electron transport
HL670_RS13725	COG4659	FMN binding
HL670_RS13735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HL670_RS13740	COG3104	oligopeptide transport
HL670_RS13750	COG1396	sequence-specific DNA binding
HL670_RS13755	COG3135	benzoate transporter
HL670_RS13800	COG1418	mRNA catabolic process
HL670_RS13815	COG0625	glutathione transferase activity
HL670_RS13830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HL670_RS13835	COG0259	pyridoxamine-phosphate oxidase activity
HL670_RS13840	COG3895	Periplasmic Protein
HL670_RS13845	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HL670_RS13850	COG3133	Outer membrane lipoprotein
HL670_RS13855	COG1846	Transcriptional regulator
HL670_RS13865	COG1566	PFAM secretion protein HlyD family protein
HL670_RS13880	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HL670_RS13885	COG4989	oxidoreductase activity
HL670_RS13890	COG3313	Fe-S protein
HL670_RS13895	COG0583	DNA-binding transcription factor activity
HL670_RS13905	COG2194	sulfuric ester hydrolase activity
HL670_RS13910	COG1309	transcriptional regulator
HL670_RS13915	COG1902	pentaerythritol trinitrate reductase activity
HL670_RS13920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HL670_RS13925	COG0346	lactoylglutathione lyase activity
HL670_RS13935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HL670_RS13940	COG0791	NLP P60 protein
HL670_RS13950	COG1609	Transcriptional regulator
HL670_RS13955	COG0583	DNA-binding transcription factor activity
HL670_RS13960	COG2814	Major facilitator Superfamily
HL670_RS13965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL670_RS13975	COG0307	riboflavin synthase, alpha
HL670_RS13980	COG0534	Mate efflux family protein
HL670_RS14020	COG1388	LysM domain
HL670_RS14020	COG1376	ErfK ybiS ycfS ynhG family protein
HL670_RS14025	COG2166	iron-sulfur cluster assembly
HL670_RS14030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL670_RS14035	COG0719	Fe-S assembly protein
HL670_RS14040	COG0396	ATPase activity
HL670_RS14050	COG0316	Belongs to the HesB IscA family
HL670_RS14060	COG2050	protein possibly involved in aromatic compounds catabolism
HL670_RS14065	COG0247	lactate metabolic process
HL670_RS14065	COG0277	FAD linked oxidase domain protein
HL670_RS14075	COG0574	Belongs to the PEP-utilizing enzyme family
HL670_RS14075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL670_RS14085	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HL670_RS14090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HL670_RS14095	COG0386	Belongs to the glutathione peroxidase family
HL670_RS14110	COG3720	iron ion transport
HL670_RS14115	COG4558	Periplasmic binding protein
HL670_RS14120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL670_RS14140	COG0095	Lipoate-protein ligase
HL670_RS14145	COG0791	NLP P60 protein
HL670_RS14150	COG2076	Multidrug Resistance protein
HL670_RS14155	COG2076	Multidrug Resistance protein
HL670_RS14160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HL670_RS14165	COG0726	polysaccharide deacetylase
HL670_RS14170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL670_RS14170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL670_RS14175	COG1215	transferase activity, transferring glycosyl groups
HL670_RS14185	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HL670_RS14190	COG0386	Belongs to the glutathione peroxidase family
HL670_RS14195	COG4139	cobalamin transport
HL670_RS14205	COG0776	regulation of translation
HL670_RS14215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HL670_RS14225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HL670_RS14230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HL670_RS14240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL670_RS14250	COG2963	transposase activity
HL670_RS14270	COG0814	amino acid
HL670_RS14300	COG0803	Belongs to the bacterial solute-binding protein 9 family
HL670_RS14305	COG1121	(ABC) transporter
HL670_RS14310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL670_RS14315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL670_RS14325	COG3001	Fructosamine kinase
HL670_RS14340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL670_RS14345	COG1988	membrane-bound metal-dependent
HL670_RS14360	COG2814	Major facilitator Superfamily
HL670_RS14365	COG0501	Belongs to the peptidase M48B family
HL670_RS14375	COG0793	Belongs to the peptidase S41A family
HL670_RS14380	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HL670_RS14385	COG1956	GAF domain-containing protein
HL670_RS14390	COG2995	paraquat-inducible protein a
HL670_RS14395	COG3008	intermembrane lipid transfer
HL670_RS14400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL670_RS14400	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HL670_RS14460	COG3493	citrate carrier protein
HL670_RS14465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HL670_RS14475	COG0583	DNA-binding transcription factor activity
HL670_RS14495	COG0477	Major facilitator Superfamily
HL670_RS14505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL670_RS14515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HL670_RS14530	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS14535	COG2211	Major facilitator Superfamily
HL670_RS14550	COG0371	Dehydrogenase
HL670_RS14560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL670_RS14565	COG1116	anion transmembrane transporter activity
HL670_RS14570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL670_RS14575	COG2358	TRAP transporter, solute receptor (TAXI family
HL670_RS14585	COG0402	S-adenosylhomocysteine deaminase activity
HL670_RS14595	COG1228	amidohydrolase
HL670_RS14610	COG1605	Chorismate mutase
HL670_RS14645	COG0531	amino acid
HL670_RS14650	COG0174	glutamine synthetase
HL670_RS14655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HL670_RS14660	COG1396	sequence-specific DNA binding
HL670_RS14660	COG1917	Cupin 2, conserved barrel domain protein
HL670_RS14665	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS14670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL670_RS14675	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS14685	COG1278	Cold shock
HL670_RS14715	COG0673	inositol 2-dehydrogenase activity
HL670_RS14740	COG0628	permease
HL670_RS14755	COG3064	Membrane
HL670_RS14765	COG0583	DNA-binding transcription factor activity
HL670_RS14770	COG0538	isocitrate dehydrogenase activity
HL670_RS14815	COG3772	lysozyme
HL670_RS14840	COG1403	HNH endonuclease
HL670_RS14885	COG0582	viral genome integration into host DNA
HL670_RS14900	COG0538	isocitrate dehydrogenase activity
HL670_RS14905	COG1187	pseudouridine synthase activity
HL670_RS14915	COG0482	sulfurtransferase activity
HL670_RS14920	COG2915	High frequency lysogenization protein hflD homolog
HL670_RS14925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HL670_RS14945	COG0745	RESPONSE REGULATOR receiver
HL670_RS14955	COG2850	peptidyl-arginine hydroxylation
HL670_RS14960	COG0583	DNA-binding transcription factor activity
HL670_RS14975	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HL670_RS14980	COG2195	Cleaves the N-terminal amino acid of tripeptides
HL670_RS14985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL670_RS14985	COG1263	PTS System
HL670_RS14990	COG1486	melibiose metabolic process
HL670_RS15010	COG4591	ABC-type transport system involved in lipoprotein release permease component
HL670_RS15020	COG4591	ABC-type transport system involved in lipoprotein release permease component
HL670_RS15035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HL670_RS15040	COG4702	Belongs to the UPF0303 family
HL670_RS15045	COG0659	secondary active sulfate transmembrane transporter activity
HL670_RS15050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HL670_RS15065	COG2890	protein-(glutamine-N5) methyltransferase activity
HL670_RS15070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HL670_RS15075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HL670_RS15085	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HL670_RS15090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HL670_RS15095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL670_RS15105	COG0193	aminoacyl-tRNA hydrolase activity
HL670_RS15110	COG0659	secondary active sulfate transmembrane transporter activity
HL670_RS15115	COG0012	GTP binding
HL670_RS15130	COG2184	nucleotidyltransferase activity
HL670_RS15140	COG0740	serine-type endopeptidase activity
HL670_RS15160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL670_RS15165	COG2313	pseudouridylate synthase activity
HL670_RS15170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL670_RS15175	COG0589	response to stress
HL670_RS15185	COG1464	Belongs to the NlpA lipoprotein family
HL670_RS15200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS15205	COG1129	ABC transporter
HL670_RS15220	COG3290	protein histidine kinase activity
HL670_RS15225	COG4565	transcriptional regulatory protein
HL670_RS15260	COG3655	Transcriptional regulator
HL670_RS15305	COG4771	TonB-dependent receptor
HL670_RS15315	COG0745	RESPONSE REGULATOR receiver
HL670_RS15325	COG1276	copper resistance
HL670_RS15330	COG2372	response to copper ion
HL670_RS15335	COG1528	Iron-storage protein
HL670_RS15355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL670_RS15360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HL670_RS15365	COG1770	oligopeptidase
HL670_RS15370	COG2979	Protein of unknown function (DUF533)
HL670_RS15375	COG3381	protein complex oligomerization
HL670_RS15380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HL670_RS15385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL670_RS15415	COG2207	Transcriptional regulator
HL670_RS15415	COG3708	Transcriptional regulator
HL670_RS15420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS15440	COG3134	Outer membrane lipoprotein
HL670_RS15445	COG1252	NADH dehydrogenase
HL670_RS15450	COG3150	esterase
HL670_RS15465	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HL670_RS15470	COG5633	Lipoprotein
HL670_RS15475	COG0537	adenosine 5'-monophosphoramidase activity
HL670_RS15485	COG1733	regulation of RNA biosynthetic process
HL670_RS15490	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS15505	COG1914	H( )-stimulated, divalent metal cation uptake system
HL670_RS15510	COG1321	iron dependent repressor
HL670_RS15515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL670_RS15515	COG1263	PTS System
HL670_RS15520	COG0084	hydrolase, TatD family'
HL670_RS15525	COG0470	DNA polymerase III
HL670_RS15530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HL670_RS15535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HL670_RS15540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL670_RS15550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL670_RS15555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL670_RS15565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HL670_RS15570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL670_RS15575	COG0416	fatty acid biosynthetic process
HL670_RS15580	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HL670_RS15585	COG1399	metal-binding, possibly nucleic acid-binding protein
HL670_RS15595	COG0564	pseudouridine synthase activity
HL670_RS15605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HL670_RS15610	COG0418	dihydroorotase activity
HL670_RS15645	COG0628	permease
HL670_RS15650	COG3038	cytochrome b561
HL670_RS15655	COG2353	YceI-like domain
HL670_RS15665	COG1902	pentaerythritol trinitrate reductase activity
HL670_RS15675	COG1560	Kdo2-lipid A biosynthetic process
HL670_RS15685	COG2814	Major facilitator Superfamily
HL670_RS15690	COG3104	oligopeptide transport
HL670_RS15695	COG0346	lactoylglutathione lyase activity
HL670_RS15710	COG0640	Transcriptional regulator
HL670_RS15720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL670_RS15735	COG5645	(Lipo)protein
HL670_RS15740	COG2943	transferase activity, transferring hexosyl groups
HL670_RS15745	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HL670_RS15760	COG3263	regulation of cellular component size
HL670_RS15780	COG0322	excinuclease ABC activity
HL670_RS15785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS15800	COG0477	Major facilitator Superfamily
HL670_RS15845	COG2197	response regulator
HL670_RS15855	COG3136	membrane protein required for alginate biosynthesis
HL670_RS15890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL670_RS15905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL670_RS15910	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS15915	COG0531	amino acid
HL670_RS15925	COG0589	response to stress
HL670_RS15930	COG2197	response regulator
HL670_RS15935	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL670_RS15945	COG0156	8-amino-7-oxononanoate synthase activity
HL670_RS15950	COG2814	Major facilitator Superfamily
HL670_RS15980	COG1113	amino acid transport
HL670_RS15985	COG1309	transcriptional regulator
HL670_RS15990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS15995	COG1335	isochorismatase
HL670_RS16000	COG0251	oxidation-reduction process
HL670_RS16005	COG2267	carboxylic ester hydrolase activity
HL670_RS16010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL670_RS16015	COG2233	PERMEase
HL670_RS16045	COG1280	lysine exporter protein (LysE YggA)
HL670_RS16050	COG0655	NAD(P)H dehydrogenase (quinone) activity
HL670_RS16070	COG0582	viral genome integration into host DNA
HL670_RS16080	COG3311	Transcriptional regulator
HL670_RS16140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HL670_RS16150	COG1566	PFAM secretion protein HlyD family protein
HL670_RS16180	COG1733	regulation of RNA biosynthetic process
HL670_RS16185	COG0702	epimerase
HL670_RS16200	COG1902	pentaerythritol trinitrate reductase activity
HL670_RS16215	COG1609	Transcriptional regulator
HL670_RS16240	COG1609	Transcriptional regulator
HL670_RS16265	COG2814	Major facilitator Superfamily
HL670_RS16330	COG3436	PFAM IS66 Orf2 family protein
HL670_RS16400	COG3344	reverse transcriptase
HL670_RS16440	COG2814	Major facilitator Superfamily
HL670_RS16465	COG1174	glycine betaine transport
HL670_RS16470	COG1174	glycine betaine transport
HL670_RS16480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL670_RS16495	COG4983	Phage plasmid primase, P4 family domain protein
HL670_RS16510	COG3596	GTP binding
HL670_RS16515	COG2378	regulation of single-species biofilm formation
HL670_RS16550	COG2003	Belongs to the UPF0758 family
HL670_RS16580	COG0670	Belongs to the BI1 family
HL670_RS16585	COG2920	part of a sulfur-relay system
HL670_RS16590	COG1254	Belongs to the acylphosphatase family
HL670_RS16595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HL670_RS16605	COG1832	CoA-binding protein
HL670_RS16615	COG1803	Methylglyoxal synthase
HL670_RS16620	COG0210	DNA helicase
HL670_RS16625	COG3304	Inner membrane component domain
HL670_RS16630	COG1289	transmembrane transporter activity
HL670_RS16635	COG3070	regulator of competence-specific genes
HL670_RS16640	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HL670_RS16650	COG3120	sequence-specific DNA binding
HL670_RS16655	COG1067	ATP-dependent peptidase activity
HL670_RS16660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL670_RS16675	COG3130	regulation of translation
HL670_RS16680	COG3009	Protein conserved in bacteria
HL670_RS16685	COG3008	intermembrane lipid transfer
HL670_RS16685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HL670_RS16695	COG0488	(ABC) transporter
HL670_RS16700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HL670_RS16700	COG0116	Belongs to the methyltransferase superfamily
HL670_RS16705	COG0633	Ferredoxin
HL670_RS16705	COG3217	Mosc domain protein beta barrel domain protein
HL670_RS16715	COG0167	dihydroorotate dehydrogenase activity
HL670_RS16720	COG0431	NADPH-dependent FMN reductase
HL670_RS16725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL670_RS16730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS16735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL670_RS16745	COG0308	aminopeptidase N
HL670_RS16755	COG3706	GGDEF domain
HL670_RS16760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HL670_RS16765	COG0017	Asparaginyl-tRNA synthetase
HL670_RS16775	COG1448	Aminotransferase
HL670_RS16780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL670_RS16785	COG3108	Peptidase M15
HL670_RS16790	COG2989	Protein conserved in bacteria
HL670_RS16795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HL670_RS16805	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HL670_RS16810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HL670_RS16815	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HL670_RS16820	COG3173	Aminoglycoside phosphotransferase
HL670_RS16825	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HL670_RS16830	COG2835	tetraacyldisaccharide 4'-kinase activity
HL670_RS16835	COG3214	Protein conserved in bacteria
HL670_RS16840	COG1278	Cold shock
HL670_RS16850	COG5383	Protein conserved in bacteria
HL670_RS16855	COG1663	tetraacyldisaccharide 4'-kinase activity
HL670_RS16865	COG2333	competence protein COMEC
HL670_RS16865	COG0658	competence protein
HL670_RS16870	COG0776	regulation of translation
HL670_RS16875	COG0539	negative regulation of cytoplasmic translation
HL670_RS16880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HL670_RS16885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HL670_RS16890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HL670_RS16910	COG0252	asparaginase activity
HL670_RS16915	COG1944	ATP diphosphatase activity
HL670_RS16920	COG2116	formate transmembrane transporter activity
HL670_RS16925	COG1882	Formate acetyltransferase
HL670_RS16930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL670_RS16955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HL670_RS16960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HL670_RS16965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HL670_RS16970	COG3107	peptidoglycan biosynthetic process
HL670_RS16970	COG1674	ftsk spoiiie
HL670_RS16980	COG0492	ferredoxin-NADP+ reductase activity
HL670_RS16985	COG0583	DNA-binding transcription factor activity
HL670_RS17000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HL670_RS17005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HL670_RS17010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HL670_RS17015	COG0542	response to heat
HL670_RS17020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HL670_RS17025	COG1278	Cold shock
HL670_RS17035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS17040	COG2990	Protein conserved in bacteria
HL670_RS17045	COG3593	DNA synthesis involved in DNA repair
HL670_RS17050	COG2431	L-lysine efflux transmembrane transporter activity
HL670_RS17055	COG1151	hydroxylamine reductase activity
HL670_RS17060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL670_RS17065	COG0028	Belongs to the TPP enzyme family
HL670_RS17070	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HL670_RS17080	COG0702	epimerase
HL670_RS17085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL670_RS17090	COG3023	N-Acetylmuramoyl-L-alanine amidase
HL670_RS17100	COG0393	Putative heavy-metal-binding
HL670_RS17110	COG1522	sequence-specific DNA binding
HL670_RS17120	COG1126	abc transporter atp-binding protein
HL670_RS17125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL670_RS17130	COG4215	(ABC) transporter
HL670_RS17135	COG4160	amino acid transport
HL670_RS17140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL670_RS17150	COG2026	Addiction module toxin, RelE StbE family
HL670_RS17155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL670_RS17165	COG1177	transmembrane transport
HL670_RS17170	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL670_RS17175	COG3842	ATPase activity
HL670_RS17180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HL670_RS17190	COG0189	ligase activity
HL670_RS17210	COG0569	domain protein
HL670_RS17210	COG2985	domain, Protein
HL670_RS17230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HL670_RS17235	COG4574	serine-type endopeptidase inhibitor activity
HL670_RS17250	COG0671	phosphoesterase, PA-phosphatase related
HL670_RS17260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HL670_RS17265	COG1349	DNA-binding transcription factor activity
HL670_RS17270	COG0814	amino acid
HL670_RS17275	COG1760	l-serine dehydratase
HL670_RS17280	COG1686	Belongs to the peptidase S11 family
HL670_RS17290	COG0626	cystathionine gamma-synthase activity
HL670_RS17305	COG0625	glutathione transferase activity
HL670_RS17310	COG2133	pyrroloquinoline quinone binding
HL670_RS17340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL670_RS17350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HL670_RS17360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL670_RS17375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HL670_RS17380	COG0107	imidazoleglycerol-phosphate synthase activity
HL670_RS17385	COG0140	phosphoribosyl-ATP diphosphatase activity
HL670_RS17385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HL670_RS17390	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HL670_RS17440	COG1088	dTDP-glucose 4,6-dehydratase activity
HL670_RS17480	COG2244	polysaccharide biosynthetic process
HL670_RS17535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HL670_RS17540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HL670_RS17550	COG1253	flavin adenine dinucleotide binding
HL670_RS17555	COG3069	C4-dicarboxylate transmembrane transporter activity
HL670_RS17565	COG0717	Belongs to the dCTP deaminase family
HL670_RS17570	COG0572	uridine kinase
HL670_RS17580	COG0489	protein tyrosine kinase activity
HL670_RS17585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL670_RS17585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL670_RS17595	COG2814	Major facilitator Superfamily
HL670_RS17600	COG1380	Effector of murein hydrolase LrgA
HL670_RS17605	COG1346	cytolysis
HL670_RS17610	COG0295	cytidine deaminase activity
HL670_RS17615	COG0281	malic enzyme
HL670_RS17620	COG2949	membrane
HL670_RS17640	COG1609	Transcriptional regulator
HL670_RS17650	COG0302	gtp cyclohydrolase
HL670_RS17660	COG0583	DNA-binding transcription factor activity
HL670_RS17685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL670_RS17690	COG0601	transmembrane transport
HL670_RS17695	COG0747	negative chemotaxis
HL670_RS17700	COG4172	Belongs to the ABC transporter superfamily
HL670_RS17705	COG1446	asparaginase
HL670_RS17715	COG0303	'Molybdopterin
HL670_RS17720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL670_RS17725	COG0488	(ABC) transporter
HL670_RS17735	COG0583	DNA-binding transcription factor activity
HL670_RS17755	COG0583	DNA-binding transcription factor activity
HL670_RS17760	COG1335	isochorismatase
HL670_RS17770	COG0640	Transcriptional regulator
HL670_RS17775	COG0625	glutathione transferase activity
HL670_RS17790	COG1309	transcriptional regulator
HL670_RS17795	COG0702	epimerase
HL670_RS17800	COG0579	oxidoreductase
HL670_RS17805	COG2207	Transcriptional regulator
HL670_RS17805	COG3708	Transcriptional regulator
HL670_RS17825	COG3539	Fimbrial protein
HL670_RS17830	COG2200	EAL domain
HL670_RS17840	COG0069	glutamate synthase activity
HL670_RS17845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HL670_RS17850	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS17855	COG1309	transcriptional regulator
HL670_RS17860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL670_RS17870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HL670_RS17875	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HL670_RS17880	COG0745	RESPONSE REGULATOR receiver
HL670_RS17885	COG5002	protein histidine kinase activity
HL670_RS17905	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HL670_RS17910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HL670_RS17920	COG3622	Belongs to the hyi family
HL670_RS17930	COG0583	DNA-binding transcription factor activity
HL670_RS17935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL670_RS17940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HL670_RS17950	COG2731	YhcH YjgK YiaL family protein
HL670_RS17955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HL670_RS17965	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HL670_RS17970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL670_RS17975	COG0765	amino acid transport
HL670_RS17980	COG1126	abc transporter atp-binding protein
HL670_RS17985	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HL670_RS17990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL670_RS18005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL670_RS18015	COG0477	Major facilitator Superfamily
HL670_RS18025	COG1280	lysine exporter protein (LysE YggA)
HL670_RS18030	COG0583	DNA-binding transcription factor activity
HL670_RS18035	COG0477	Major facilitator Superfamily
HL670_RS18040	COG0697	spore germination
HL670_RS18045	COG1522	sequence-specific DNA binding
HL670_RS18050	COG1199	ATP-dependent helicase activity
HL670_RS18055	COG1942	4-Oxalocrotonate Tautomerase
HL670_RS18060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL670_RS18075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HL670_RS18125	COG0697	spore germination
HL670_RS18135	COG0583	DNA-binding transcription factor activity
HL670_RS18160	COG1174	glycine betaine transport
HL670_RS18165	COG1125	glycine betaine transport
HL670_RS18170	COG1174	glycine betaine transport
HL670_RS18175	COG1732	Glycine betaine
HL670_RS18195	COG0583	DNA-binding transcription factor activity
HL670_RS18200	COG1335	isochorismatase
HL670_RS18225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL670_RS18240	COG1683	Conserved Protein
HL670_RS18250	COG2897	thiosulfate sulfurtransferase activity
HL670_RS18255	COG0583	DNA-binding transcription factor activity
HL670_RS18285	COG3511	phospholipase C
HL670_RS18320	COG1802	Transcriptional regulator
HL670_RS18345	COG4807	Protein conserved in bacteria
HL670_RS18360	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HL670_RS18370	COG1063	alcohol dehydrogenase
HL670_RS18375	COG1802	Transcriptional regulator
HL670_RS18380	COG2271	Major facilitator Superfamily
HL670_RS18390	COG0583	DNA-binding transcription factor activity
HL670_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS18420	COG0583	DNA-binding transcription factor activity
HL670_RS18425	COG0456	acetyltransferase
HL670_RS18430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HL670_RS18435	COG2011	ABC-type metal ion transport system permease component
HL670_RS18445	COG1309	transcriptional regulator
HL670_RS18460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL670_RS18505	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HL670_RS18510	COG1070	Carbohydrate kinase
HL670_RS18520	COG0583	DNA-binding transcription factor activity
HL670_RS18535	COG1192	Involved in chromosome partitioning
HL670_RS18550	COG2267	carboxylic ester hydrolase activity
HL670_RS18580	COG2226	methyltransferase
HL670_RS18585	COG0717	Belongs to the dCTP deaminase family
HL670_RS18630	COG1472	Belongs to the glycosyl hydrolase 3 family
HL670_RS18640	COG0436	Aminotransferase
HL670_RS18655	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL670_RS18670	COG0277	FAD linked oxidase domain protein
HL670_RS18675	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS18690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL670_RS18705	COG1464	Belongs to the NlpA lipoprotein family
HL670_RS18720	COG0697	spore germination
HL670_RS18730	COG2354	Protein conserved in bacteria
HL670_RS18745	COG1686	Belongs to the peptidase S11 family
HL670_RS18750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HL670_RS18765	COG0586	Pfam SNARE associated Golgi protein
HL670_RS18770	COG1280	lysine exporter protein (LysE YggA)
HL670_RS18795	COG0583	DNA-binding transcription factor activity
HL670_RS18835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HL670_RS18840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL670_RS18845	COG0513	Belongs to the DEAD box helicase family
HL670_RS18850	COG1309	transcriptional regulator
HL670_RS18855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS18860	COG1131	(ABC) transporter
HL670_RS18865	COG0842	Transport permease protein
HL670_RS18870	COG0842	Transport permease protein
HL670_RS18875	COG0670	Belongs to the BI1 family
HL670_RS18880	COG0314	molybdopterin synthase activity
HL670_RS18885	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HL670_RS18890	COG0315	cyclic pyranopterin monophosphate synthase activity
HL670_RS18895	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL670_RS18900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL670_RS18905	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HL670_RS18910	COG4628	conserved protein (DUF2132)
HL670_RS18915	COG0556	nucleotide-excision repair
HL670_RS18940	COG0156	8-amino-7-oxononanoate synthase activity
HL670_RS18945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HL670_RS18960	COG1881	PFAM PEBP family protein
HL670_RS18965	COG2706	6-phosphogluconolactonase activity
HL670_RS18995	COG2755	lipolytic protein G-D-S-L family
HL670_RS18995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL670_RS19010	COG3299	homolog of phage Mu protein gp47
HL670_RS19060	COG4386	tail sheath protein
HL670_RS19135	COG0561	phosphatase activity
HL670_RS19145	COG4149	molybdate abc transporter
HL670_RS19150	COG0725	ABC transporter, periplasmic molybdate-binding protein
HL670_RS19160	COG3585	molybdate ion transport
HL670_RS19160	COG2005	Transcriptional regulator
HL670_RS19165	COG1119	ATPase activity
HL670_RS19180	COG1085	galactose-1-phosphate uridylyltransferase
HL670_RS19185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HL670_RS19190	COG2017	converts alpha-aldose to the beta-anomer
HL670_RS19200	COG0588	phosphoglycerate mutase activity
HL670_RS19230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HL670_RS19235	COG2197	response regulator
HL670_RS19240	COG2205	protein histidine kinase activity
HL670_RS19240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL670_RS19245	COG1230	cation diffusion facilitator family transporter
HL670_RS19255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HL670_RS19300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HL670_RS19305	COG2885	chlorophyll binding
HL670_RS19310	COG0823	Involved in the tonB-independent uptake of proteins
HL670_RS19315	COG3064	Membrane
HL670_RS19315	COG3064	Membrane
HL670_RS19320	COG0848	biopolymer transport protein
HL670_RS19325	COG0811	peptide transport
HL670_RS19330	COG0824	Thioesterase
HL670_RS19335	COG3790	cyd operon protein YbgE
HL670_RS19340	COG4890	Cyd operon protein YbgT
HL670_RS19345	COG1294	oxidase, subunit
HL670_RS19350	COG1271	oxidase subunit
HL670_RS19355	COG0737	Belongs to the 5'-nucleotidase family
HL670_RS19360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HL670_RS19365	COG0045	succinate-CoA ligase (ADP-forming) activity
HL670_RS19370	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL670_RS19375	COG0567	Dehydrogenase, E1 component
HL670_RS19380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HL670_RS19390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HL670_RS19405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL670_RS19425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HL670_RS19430	COG1984	allophanate hydrolase subunit 2
HL670_RS19435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HL670_RS19440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HL670_RS19445	COG5212	phosphodiesterase
HL670_RS19455	COG3272	Protein of unknown function (DUF1722)
HL670_RS19470	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HL670_RS19475	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HL670_RS19480	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HL670_RS19485	COG2205	protein histidine kinase activity
HL670_RS19490	COG0745	RESPONSE REGULATOR receiver
HL670_RS19500	COG1695	Transcriptional regulator
HL670_RS19505	COG0033	Phosphoglucomutase
HL670_RS19510	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HL670_RS19515	COG0596	Alpha beta hydrolase
HL670_RS19530	COG0735	belongs to the Fur family
HL670_RS19545	COG2814	Major facilitator Superfamily
HL670_RS19565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL670_RS19575	COG0363	glucosamine-6-phosphate deaminase activity
HL670_RS19580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HL670_RS19585	COG1846	Transcriptional regulator
HL670_RS19585	COG1940	carbohydrate kinase activity
HL670_RS19590	COG0647	UMP catabolic process
HL670_RS19595	COG3469	chitinase activity
HL670_RS19600	COG0367	asparagine synthase
HL670_RS19635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL670_RS19640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL670_RS19645	COG2824	Alkylphosphonate utilization operon protein PhnA
HL670_RS19650	COG1702	phosphate starvation-inducible protein PhoH
HL670_RS19655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HL670_RS19660	COG4535	Mg2 and Co2 transporter CorC
HL670_RS19665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HL670_RS19675	COG0765	amino acid transport
HL670_RS19680	COG0765	amino acid transport
HL670_RS19685	COG1126	abc transporter atp-binding protein
HL670_RS19690	COG1957	nucleoside hydrolase
HL670_RS19700	COG2888	peptidyl-tyrosine sulfation
HL670_RS19705	COG0495	leucyl-tRNA aminoacylation
HL670_RS19710	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HL670_RS19715	COG1466	dna polymerase III delta subunit
HL670_RS19720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HL670_RS19725	COG0799	negative regulation of ribosome biogenesis
HL670_RS19730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HL670_RS19735	COG0768	penicillin binding
HL670_RS19740	COG0772	Belongs to the SEDS family
HL670_RS19745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HL670_RS19750	COG1686	Belongs to the peptidase S11 family
HL670_RS19755	COG2921	Belongs to the UPF0250 family
HL670_RS19760	COG0321	lipoyl(octanoyl) transferase activity
HL670_RS19765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HL670_RS19775	COG3706	GGDEF domain
HL670_RS19785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HL670_RS19795	COG2814	Major facilitator Superfamily
HL670_RS19805	COG1473	amidohydrolase
HL670_RS19810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS19820	COG0765	amino acid transport
HL670_RS19825	COG1126	abc transporter atp-binding protein
HL670_RS19835	COG1278	Cold shock
HL670_RS19860	COG0667	Aldo Keto reductase
HL670_RS19930	COG0583	DNA-binding transcription factor activity
HL670_RS19940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HL670_RS19945	COG1074	ATP-dependent DNA helicase activity
HL670_RS19970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HL670_RS19975	COG2501	S4 domain
HL670_RS19980	COG0215	cysteine-tRNA ligase activity
HL670_RS19985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL670_RS19990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL670_RS19995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HL670_RS20000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HL670_RS20010	COG2814	Major facilitator Superfamily
HL670_RS20015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HL670_RS20020	COG4181	ATPase activity
HL670_RS20025	COG2755	lipolytic protein G-D-S-L family
HL670_RS20030	COG0300	oxidoreductase activity
HL670_RS20035	COG3118	belongs to the thioredoxin family
HL670_RS20040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL670_RS20045	COG0330	HflC and HflK could
HL670_RS20050	COG1585	Membrane protein implicated in regulation of membrane protease activity
HL670_RS20055	COG0789	Transcriptional regulator
HL670_RS20060	COG2217	Heavy metal translocating P-type atpase
HL670_RS20065	COG3735	TraB family
HL670_RS20070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HL670_RS20075	COG0737	Belongs to the 5'-nucleotidase family
HL670_RS20080	COG2223	nitrite transmembrane transporter activity
HL670_RS20090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL670_RS20095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HL670_RS20100	COG0563	adenylate kinase activity
HL670_RS20105	COG0326	Molecular chaperone. Has ATPase activity
HL670_RS20110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HL670_RS20125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HL670_RS20130	COG2832	Protein of unknown function (DUF454)
HL670_RS20150	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HL670_RS20155	COG1309	transcriptional regulator
HL670_RS20160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL670_RS20165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL670_RS20170	COG0254	rRNA binding
HL670_RS20175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL670_RS20180	COG0803	Belongs to the bacterial solute-binding protein 9 family
HL670_RS20185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL670_RS20190	COG1121	(ABC) transporter
HL670_RS20215	COG3397	chitin binding
HL670_RS20250	COG2165	general secretion pathway protein
HL670_RS20305	COG3695	enzyme binding
HL670_RS20310	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HL670_RS20315	COG1946	Acyl-CoA thioesterase
HL670_RS20320	COG0004	ammonium transporteR
HL670_RS20325	COG0347	Belongs to the P(II) protein family
HL670_RS20330	COG1132	(ABC) transporter
HL670_RS20335	COG1132	(ABC) transporter
HL670_RS20340	COG1522	sequence-specific DNA binding
HL670_RS20350	COG0561	phosphatase activity
HL670_RS20355	COG4533	DNA binding
HL670_RS20360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HL670_RS20365	COG0824	Thioesterase
HL670_RS20370	COG1555	photosystem II stabilization
HL670_RS20375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL670_RS20385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL670_RS20390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HL670_RS20400	COG0544	peptidyl-prolyl cis-trans isomerase activity
HL670_RS20405	COG0271	Belongs to the BolA IbaG family
HL670_RS20410	COG3056	Lipoprotein
HL670_RS20415	COG2223	nitrite transmembrane transporter activity
HL670_RS20420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HL670_RS20425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HL670_RS20430	COG1845	cytochrome c oxidase, subunit III
HL670_RS20435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HL670_RS20440	COG0109	protoheme IX farnesyltransferase activity
HL670_RS20445	COG2814	Major facilitator Superfamily
HL670_RS20450	COG1666	GTP binding
HL670_RS20455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HL670_RS20460	COG0693	protein deglycase activity
HL670_RS20465	COG0301	tRNA thio-modification
HL670_RS20465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL670_RS20470	COG1722	exodeoxyribonuclease VII activity
HL670_RS20475	COG0142	geranyltranstransferase activity
HL670_RS20480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HL670_RS20485	COG0667	Aldo Keto reductase
HL670_RS20490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HL670_RS20495	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HL670_RS20500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL670_RS20505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HL670_RS20510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL670_RS20510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL670_RS20515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL670_RS20525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL670_RS20535	COG1862	Preprotein translocase
HL670_RS20540	COG0343	queuine tRNA-ribosyltransferase activity
HL670_RS20545	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HL670_RS20550	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HL670_RS20555	COG0450	alkyl hydroperoxide reductase
HL670_RS20565	COG0366	Alpha amylase catalytic
HL670_RS20570	COG0668	transmembrane transport
HL670_RS20590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HL670_RS20600	COG5002	protein histidine kinase activity
HL670_RS20605	COG0745	RESPONSE REGULATOR receiver
HL670_RS20610	COG0420	3'-5' exonuclease activity
HL670_RS20615	COG0419	ATPase involved in DNA repair
HL670_RS20635	COG1940	carbohydrate kinase activity
HL670_RS20650	COG0191	fructose-bisphosphate aldolase activity
HL670_RS20665	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS20670	COG1129	ABC transporter
HL670_RS20680	COG2974	May be involved in recombination
HL670_RS20690	COG3123	guanosine phosphorylase activity
HL670_RS20715	COG0667	Aldo Keto reductase
HL670_RS20720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL670_RS20765	COG2226	methyltransferase
HL670_RS20775	COG3416	Protein conserved in bacteria
HL670_RS20810	COG1335	isochorismatase
HL670_RS20830	COG1349	DNA-binding transcription factor activity
HL670_RS20855	COG3961	Belongs to the TPP enzyme family
HL670_RS20860	COG0583	DNA-binding transcription factor activity
HL670_RS20895	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS20900	COG2207	Transcriptional regulator
HL670_RS20905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL670_RS20920	COG3391	amine dehydrogenase activity
HL670_RS20925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS20930	COG1629	transport
HL670_RS20930	COG4774	siderophore transport
HL670_RS20935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS20940	COG3433	isochorismatase activity
HL670_RS20940	COG2226	methyltransferase
HL670_RS20940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL670_RS20950	COG0747	negative chemotaxis
HL670_RS20955	COG3038	cytochrome b561
HL670_RS20970	COG0604	alcohol dehydrogenase
HL670_RS20990	COG1902	pentaerythritol trinitrate reductase activity
HL670_RS20995	COG1309	transcriptional regulator
HL670_RS21005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HL670_RS21020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HL670_RS21025	COG2195	Cleaves the N-terminal amino acid of tripeptides
HL670_RS21115	COG3121	Chaperone
HL670_RS21120	COG3539	Fimbrial protein
HL670_RS21165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL670_RS21175	COG2991	Protein conserved in bacteria
HL670_RS21180	COG1477	protein flavinylation
HL670_RS21185	COG2871	sodium ion transport
HL670_RS21190	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HL670_RS21195	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HL670_RS21200	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HL670_RS21205	COG1805	sodium ion transport
HL670_RS21210	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HL670_RS21215	COG3034	peptidoglycan biosynthetic process
HL670_RS21220	COG0121	glutamine amidotransferase
HL670_RS21225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HL670_RS21230	COG1960	acyl-CoA dehydrogenase activity
HL670_RS21245	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HL670_RS21250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HL670_RS21255	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HL670_RS21260	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HL670_RS21265	COG0235	Class ii aldolase
HL670_RS21270	COG0436	Aminotransferase
HL670_RS21280	COG1280	lysine exporter protein (LysE YggA)
HL670_RS21300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HL670_RS21305	COG1126	abc transporter atp-binding protein
HL670_RS21410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HL670_RS21415	COG0328	RNA-DNA hybrid ribonuclease activity
HL670_RS21420	COG2226	methyltransferase
HL670_RS21425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL670_RS21430	COG0741	lytic transglycosylase activity
HL670_RS21430	COG1388	LysM domain
HL670_RS21445	COG0583	DNA-binding transcription factor activity
HL670_RS21450	COG0656	L-ascorbic acid biosynthetic process
HL670_RS21460	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS21465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL670_RS21470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL670_RS21515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL670_RS21565	COG0542	response to heat
HL670_RS21575	COG0564	pseudouridine synthase activity
HL670_RS21580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL670_RS21585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HL670_RS21590	COG0077	Prephenate dehydratase
HL670_RS21590	COG1605	Chorismate mutase
HL670_RS21595	COG1605	Chorismate mutase
HL670_RS21595	COG0287	Prephenate dehydrogenase
HL670_RS21600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HL670_RS21605	COG3137	Salt-induced outer membrane protein
HL670_RS21670	COG5301	cellulose 1,4-beta-cellobiosidase activity
HL670_RS21720	COG0335	large ribosomal subunit rRNA binding
HL670_RS21725	COG0336	Belongs to the RNA methyltransferase TrmD family
HL670_RS21730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HL670_RS21735	COG0228	four-way junction DNA binding
HL670_RS21740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HL670_RS21745	COG4137	Cytochrome C assembly protein
HL670_RS21750	COG4536	flavin adenine dinucleotide binding
HL670_RS21755	COG1854	S-ribosylhomocysteine lyase activity
HL670_RS21760	COG2918	glutathione biosynthetic process
HL670_RS21765	COG1238	metal cluster binding
HL670_RS21770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL670_RS21795	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HL670_RS21800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HL670_RS21805	COG2137	regulation of response to DNA damage stimulus
HL670_RS21810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HL670_RS21830	COG2169	Transcriptional regulator
HL670_RS21830	COG1917	Cupin 2, conserved barrel domain protein
HL670_RS21835	COG2723	6-phospho-beta-galactosidase activity
HL670_RS21840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL670_RS21845	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL670_RS21860	COG0667	Aldo Keto reductase
HL670_RS21870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HL670_RS21875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL670_RS21880	COG1388	LysM domain
HL670_RS21880	COG4942	peptidase
HL670_RS21885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HL670_RS21890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HL670_RS21895	COG0585	pseudouridine synthase activity
HL670_RS21900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HL670_RS21905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HL670_RS21910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HL670_RS21920	COG0529	Catalyzes the synthesis of activated sulfate
HL670_RS21925	COG2895	sulfate adenylyltransferase (ATP) activity
HL670_RS21930	COG0175	sulfate reduction
HL670_RS21935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HL670_RS21935	COG1648	precorrin-2 dehydrogenase activity
HL670_RS21940	COG2234	aminopeptidase activity
HL670_RS21945	COG0175	sulfate reduction
HL670_RS21955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HL670_RS21960	COG0720	synthase
HL670_RS21975	COG0602	queuosine metabolic process
HL670_RS21980	COG2271	Major facilitator Superfamily
HL670_RS21985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HL670_RS21990	COG2986	histidine ammonia-lyase
HL670_RS22020	COG0504	CTP synthase activity
HL670_RS22025	COG3956	TIGRFAM MazG family protein
HL670_RS22030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HL670_RS22045	COG1929	Belongs to the glycerate kinase type-1 family
HL670_RS22050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL670_RS22055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HL670_RS22060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HL670_RS22070	COG2860	membrane
HL670_RS22075	COG0316	Belongs to the HesB IscA family
HL670_RS22085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL670_RS22090	COG3725	Membrane protein required for beta-lactamase induction
HL670_RS22095	COG3023	N-Acetylmuramoyl-L-alanine amidase
HL670_RS22105	COG4969	Belongs to the N-Me-Phe pilin family
HL670_RS22150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HL670_RS22160	COG1459	type II secretion system
HL670_RS22170	COG0237	dephospho-CoA kinase activity
HL670_RS22175	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HL670_RS22180	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HL670_RS22185	COG0494	nUDIX hydrolase
HL670_RS22190	COG0653	protein targeting
HL670_RS22210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HL670_RS22215	COG0849	cell division
HL670_RS22220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HL670_RS22225	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL670_RS22230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL670_RS22235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HL670_RS22240	COG0772	Belongs to the SEDS family
HL670_RS22250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL670_RS22255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HL670_RS22260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HL670_RS22265	COG0768	penicillin binding
HL670_RS22270	COG3116	cell division
HL670_RS22275	COG0275	rRNA processing
HL670_RS22280	COG2001	Belongs to the MraZ family
HL670_RS22300	COG0028	Belongs to the TPP enzyme family
HL670_RS22305	COG1022	Amp-dependent synthetase and ligase
HL670_RS22320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL670_RS22325	COG0473	3-isopropylmalate dehydrogenase activity
HL670_RS22330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HL670_RS22335	COG0066	3-isopropylmalate dehydratase activity
HL670_RS22340	COG0471	metal ion transport
HL670_RS22345	COG2814	Major facilitator Superfamily
HL670_RS22360	COG4143	(ABC) transporter
HL670_RS22365	COG1178	ABC-type Fe3 transport system permease component
HL670_RS22380	COG0028	Belongs to the TPP enzyme family
HL670_RS22385	COG0440	acetolactate synthase activity
HL670_RS22390	COG0586	Pfam SNARE associated Golgi protein
HL670_RS22395	COG0417	DNA replication proofreading
HL670_RS22400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL670_RS22405	COG0564	pseudouridine synthase activity
HL670_RS22415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HL670_RS22425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HL670_RS22430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HL670_RS22435	COG2967	ApaG domain
HL670_RS22440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HL670_RS22450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HL670_RS22460	COG2966	Psort location CytoplasmicMembrane, score
HL670_RS22470	COG0475	glutathione-regulated potassium exporter activity
HL670_RS22470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HL670_RS22480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HL670_RS22485	COG0505	Belongs to the CarA family
HL670_RS22490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HL670_RS22515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HL670_RS22520	COG1047	Peptidyl-prolyl cis-trans
HL670_RS22525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HL670_RS22530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HL670_RS22535	COG0196	riboflavin kinase activity
HL670_RS22550	COG0268	Binds directly to 16S ribosomal RNA
HL670_RS22555	COG0583	DNA-binding transcription factor activity
HL670_RS22560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HL670_RS22565	COG0484	heat shock protein binding
HL670_RS22570	COG0443	Heat shock 70 kDa protein
HL670_RS22575	COG1584	GPR1 FUN34 yaaH family protein
HL670_RS22585	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL670_RS22590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL670_RS22595	COG1115	amino acid carrier protein
HL670_RS22600	COG3022	response to hydroperoxide
HL670_RS22610	COG0083	homoserine kinase activity
HL670_RS22630	COG0745	RESPONSE REGULATOR receiver
HL670_RS22635	COG3045	CreA protein
HL670_RS22640	COG2207	Transcriptional regulator
HL670_RS22640	COG3708	Transcriptional regulator
HL670_RS22645	COG0406	alpha-ribazole phosphatase activity
HL670_RS22650	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HL670_RS22655	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HL670_RS22660	COG0741	lytic transglycosylase activity
HL670_RS22670	COG2199	diguanylate cyclase activity
HL670_RS22675	COG2885	chlorophyll binding
HL670_RS22680	COG0488	(ABC) transporter
HL670_RS22690	COG0604	alcohol dehydrogenase
HL670_RS22705	COG0560	Phosphoserine phosphatase
HL670_RS22710	COG3726	membrane protein affecting hemolysin expression
HL670_RS22715	COG3550	peptidyl-serine autophosphorylation
HL670_RS22725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HL670_RS22730	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HL670_RS22735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HL670_RS22740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL670_RS22745	COG0084	hydrolase, TatD family'
HL670_RS22750	COG4667	esterase of the alpha-beta hydrolase superfamily
HL670_RS22755	COG3237	CsbD-like
HL670_RS22760	COG5487	UPF0391 membrane protein
HL670_RS22765	COG2823	Periplasmic or secreted lipoprotein
HL670_RS22770	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HL670_RS22775	COG3550	peptidyl-serine autophosphorylation
HL670_RS22790	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HL670_RS22795	COG2813	Specifically methylates the guanine in position
HL670_RS22800	COG0667	Aldo Keto reductase
HL670_RS22830	COG3706	GGDEF domain
HL670_RS22835	COG1309	transcriptional regulator
HL670_RS22855	COG0738	Major facilitator superfamily
HL670_RS22860	COG3254	rhamnose metabolic process
HL670_RS22865	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS22870	COG3618	amidohydrolase
HL670_RS22875	COG4948	Mandelate Racemase Muconate Lactonizing
HL670_RS22880	COG0179	Fumarylacetoacetate (FAA) hydrolase
HL670_RS22885	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS22895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HL670_RS22900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL670_RS22905	COG2368	4-hydroxyphenylacetate
HL670_RS22925	COG3971	2-oxopent-4-enoate hydratase activity
HL670_RS22940	COG1012	belongs to the aldehyde dehydrogenase family
HL670_RS22955	COG1846	Transcriptional regulator
HL670_RS22980	COG1113	amino acid transport
HL670_RS23000	COG2267	carboxylic ester hydrolase activity
HL670_RS23010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL670_RS23020	COG1454	alcohol dehydrogenase
HL670_RS23070	COG0811	peptide transport
HL670_RS23100	COG1376	ErfK ybiS ycfS ynhG family protein
HL670_RS23105	COG3708	Transcriptional regulator
HL670_RS23105	COG2207	Transcriptional regulator
HL670_RS23110	COG2207	Transcriptional regulator
HL670_RS23120	COG3391	amine dehydrogenase activity
HL670_RS23140	COG0174	glutamine synthetase
HL670_RS23165	COG2879	small protein
HL670_RS23170	COG0523	cobalamin synthesis protein
HL670_RS23175	COG2814	Major facilitator Superfamily
HL670_RS23185	COG1609	Transcriptional regulator
HL670_RS23195	COG2723	6-phospho-beta-galactosidase activity
HL670_RS23220	COG3727	T/G mismatch-specific endonuclease activity
HL670_RS23240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HL670_RS23240	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HL670_RS23290	COG0795	lipopolysaccharide-transporting ATPase activity
HL670_RS23295	COG0795	lipopolysaccharide-transporting ATPase activity
HL670_RS23300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HL670_RS23305	COG2927	DNA polymerase III (CHI subunit)
HL670_RS23315	COG0456	acetyltransferase
HL670_RS23325	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HL670_RS23335	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HL670_RS23340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HL670_RS23350	COG0540	Belongs to the ATCase OTCase family
HL670_RS23365	COG2308	Evidence 4 Homologs of previously reported genes of
HL670_RS23385	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HL670_RS23390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HL670_RS23395	COG1609	Transcriptional regulator
HL670_RS23435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL670_RS23435	COG1263	PTS System
HL670_RS23440	COG0366	Alpha amylase catalytic
HL670_RS23445	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL670_RS23450	COG0583	DNA-binding transcription factor activity
HL670_RS23465	COG0701	Predicted permease
HL670_RS23470	COG2188	Transcriptional regulator
HL670_RS23475	COG3624	Phosphonate C-P lyase system protein PhnG
HL670_RS23480	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HL670_RS23485	COG3626	phosphonate metabolism
HL670_RS23490	COG3627	carbon phosphorus lyase activity
HL670_RS23495	COG4107	phosphonate C-P lyase system protein PhnK
HL670_RS23500	COG4778	phosphonate C-P lyase system protein PhnL
HL670_RS23505	COG3454	Phosphonate metabolism
HL670_RS23510	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HL670_RS23525	COG0702	epimerase
HL670_RS23530	COG3787	Belongs to the UPF0306 family
HL670_RS23540	COG2827	Endonuclease containing a URI domain
HL670_RS23545	COG3153	acetyltransferase
HL670_RS23550	COG3154	lipid carrier protein
HL670_RS23555	COG0826	peptidase U32
HL670_RS23560	COG0826	peptidase U32
HL670_RS23595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL670_RS23600	COG0477	Major facilitator Superfamily
HL670_RS23610	COG0425	Belongs to the sulfur carrier protein TusA family
HL670_RS23620	COG0513	Belongs to the DEAD box helicase family
HL670_RS23635	COG1185	polyribonucleotide nucleotidyltransferase activity
HL670_RS23640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HL670_RS23645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HL670_RS23650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HL670_RS23655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL670_RS23660	COG0195	Participates in both transcription termination and antitermination
HL670_RS23665	COG0779	Required for maturation of 30S ribosomal subunits
HL670_RS23680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HL670_RS23685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL670_RS23690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HL670_RS23700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HL670_RS23705	COG1534	Rna-binding protein
HL670_RS23715	COG2027	D-alanyl-D-alanine carboxypeptidase
HL670_RS23720	COG0745	RESPONSE REGULATOR receiver
HL670_RS23725	COG0642	Histidine kinase
HL670_RS23730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL670_RS23735	COG0697	spore germination
HL670_RS23740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HL670_RS23745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HL670_RS23750	COG0142	geranyltranstransferase activity
HL670_RS23760	COG3423	Transcriptional regulator
HL670_RS23765	COG0039	L-malate dehydrogenase activity
HL670_RS23770	COG1438	arginine binding
HL670_RS23785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL670_RS23790	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HL670_RS23800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HL670_RS23805	COG2105	PFAM AIG2 family protein
HL670_RS23810	COG2911	Protein conserved in bacteria
HL670_RS23815	COG0729	surface antigen
HL670_RS23820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL670_RS23825	COG1253	flavin adenine dinucleotide binding
HL670_RS23835	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HL670_RS23840	COG1218	3'(2'),5'-bisphosphate nucleotidase
HL670_RS23845	COG0737	Belongs to the 5'-nucleotidase family
HL670_RS23850	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HL670_RS23855	COG0545	Peptidyl-prolyl cis-trans isomerase
HL670_RS23860	COG3061	Opacity-associated protein A
HL670_RS23870	COG0359	binds to the 23S rRNA
HL670_RS23875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HL670_RS23885	COG0360	Binds together with S18 to 16S ribosomal RNA
HL670_RS23895	COG1073	alpha beta
HL670_RS23900	COG3650	response to hydrogen peroxide
HL670_RS23920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL670_RS23930	COG1959	2 iron, 2 sulfur cluster binding
HL670_RS23935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HL670_RS23940	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HL670_RS23945	COG0330	HflC and HflK could
HL670_RS23950	COG0330	HflC and HflK could
HL670_RS23955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HL670_RS23960	COG1923	regulation of RNA biosynthetic process
HL670_RS23965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL670_RS23970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HL670_RS23980	COG0802	atpase or kinase
HL670_RS23985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HL670_RS23985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HL670_RS23990	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HL670_RS24010	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HL670_RS24015	COG1162	GTPase activity
HL670_RS24020	COG0688	phosphatidylethanolamine metabolic process
HL670_RS24025	COG3264	Mechanosensitive ion channel
HL670_RS24025	COG1511	domain protein
HL670_RS24030	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HL670_RS24035	COG1053	succinate dehydrogenase
HL670_RS24040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HL670_RS24045	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HL670_RS24050	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HL670_RS24065	COG5510	response to toxic substance
HL670_RS24070	COG5510	response to toxic substance
HL670_RS24075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HL670_RS24090	COG0459	protein refolding
HL670_RS24095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL670_RS24110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HL670_RS24120	COG4232	protein-disulfide reductase activity
HL670_RS24125	COG1309	transcriptional regulator
HL670_RS24135	COG1473	amidohydrolase
HL670_RS24140	COG0700	Nucleoside recognition
HL670_RS24145	COG3366	ferrous iron transmembrane transporter activity
HL670_RS24150	COG0583	DNA-binding transcription factor activity
HL670_RS24155	COG0659	secondary active sulfate transmembrane transporter activity
HL670_RS24160	COG0288	reversible hydration of carbon dioxide
HL670_RS24170	COG1301	dicarboxylic acid transport
HL670_RS24175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HL670_RS24180	COG3162	membrane
HL670_RS24185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL670_RS24220	COG0138	bifunctional purine biosynthesis protein purh
HL670_RS24225	COG0151	Belongs to the GarS family
HL670_RS24245	COG1515	deoxyribonuclease V activity
HL670_RS24250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HL670_RS24255	COG2816	NAD+ diphosphatase activity
HL670_RS24260	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HL670_RS24270	COG0352	thiamine-phosphate diphosphorylase activity
HL670_RS24275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL670_RS24280	COG2104	thiamine diphosphate biosynthetic process
HL670_RS24285	COG2022	thiamine diphosphate biosynthetic process
HL670_RS24300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HL670_RS24305	COG0085	RNA polymerase activity
HL670_RS24310	COG0222	ribosome binding
HL670_RS24315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HL670_RS24320	COG0081	regulation of translation
HL670_RS24325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HL670_RS24330	COG0250	Participates in transcription elongation, termination and antitermination
HL670_RS24340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL670_RS24375	COG1072	(Pantothenic acid kinase))
HL670_RS24380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HL670_RS24380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HL670_RS24385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HL670_RS24410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HL670_RS24415	COG4206	TonB-dependent receptor
HL670_RS24420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL670_RS24435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL670_RS24445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HL670_RS24445	COG0678	peroxiredoxin activity
HL670_RS24450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL670_RS24455	COG0165	Argininosuccinate lyase
HL670_RS24460	COG0137	argininosuccinate synthase activity
HL670_RS24465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL670_RS24480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HL670_RS24505	COG0626	cystathionine gamma-synthase activity
HL670_RS24510	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HL670_RS24515	COG0254	rRNA binding
HL670_RS24520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HL670_RS24525	COG1609	Transcriptional regulator
HL670_RS24530	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HL670_RS24535	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HL670_RS24540	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HL670_RS24545	COG1575	Belongs to the MenA family. Type 1 subfamily
HL670_RS24550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HL670_RS24555	COG3074	FtsZ-dependent cytokinesis
HL670_RS24560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HL670_RS24570	COG1494	fructose-1,6-bisphosphatase
HL670_RS24575	COG2814	Major facilitator Superfamily
HL670_RS24590	COG3152	Membrane
HL670_RS24600	COG0149	triose-phosphate isomerase activity
HL670_RS24605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HL670_RS24610	COG0205	6-phosphofructokinase activity
HL670_RS24615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HL670_RS24620	COG3678	ATP-independent chaperone mediated protein folding
HL670_RS24625	COG0745	RESPONSE REGULATOR receiver
HL670_RS24635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HL670_RS24650	COG1045	serine acetyltransferase
HL670_RS24655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HL670_RS24665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HL670_RS24670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL670_RS24675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HL670_RS24680	COG4942	peptidase
HL670_RS24685	COG2861	carbohydrate metabolic process
HL670_RS24690	COG1063	alcohol dehydrogenase
HL670_RS24695	COG0156	8-amino-7-oxononanoate synthase activity
HL670_RS24700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL670_RS24705	COG0859	PFAM glycosyl transferase family 9
HL670_RS24710	COG0859	PFAM glycosyl transferase family 9
HL670_RS24715	COG0438	transferase activity, transferring glycosyl groups
HL670_RS24720	COG3307	-O-antigen
HL670_RS24725	COG1216	Glycosyl transferase, family 2
HL670_RS24725	COG1442	glycosyl transferase family 8
HL670_RS24740	COG0859	PFAM glycosyl transferase family 9
HL670_RS24745	COG0438	transferase activity, transferring glycosyl groups
HL670_RS24750	COG0438	transferase activity, transferring glycosyl groups
HL670_RS24760	COG1519	Transferase
HL670_RS24785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL670_RS24790	COG2003	Belongs to the UPF0758 family
HL670_RS24795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HL670_RS24800	COG0756	dUTP diphosphatase activity
HL670_RS24805	COG1309	transcriptional regulator
HL670_RS24810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HL670_RS24815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HL670_RS24820	COG1561	YicC-like family, N-terminal region
HL670_RS24830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL670_RS24835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL670_RS24845	COG2860	membrane
HL670_RS24850	COG0583	DNA-binding transcription factor activity
HL670_RS24860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL670_RS24865	COG0194	GDP metabolic process
HL670_RS24870	COG1758	RNA polymerase activity
HL670_RS24875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HL670_RS24880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL670_RS24885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL670_RS24890	COG0786	glutamate:sodium symporter activity
HL670_RS24895	COG2233	PERMEase
HL670_RS24900	COG2982	Protein involved in outer membrane biogenesis
HL670_RS24905	COG0456	acetyltransferase
HL670_RS24910	COG1490	D-aminoacyl-tRNA deacylase activity
HL670_RS24915	COG1295	ribonuclease BN
HL670_RS24920	COG1011	Hydrolase
HL670_RS24935	COG3852	Histidine kinase
HL670_RS24955	COG3078	GTPase activator activity
HL670_RS24960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HL670_RS24965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL670_RS24965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL670_RS24970	COG0204	Acyl-transferase
HL670_RS24975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL670_RS24980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HL670_RS24985	COG3084	Protein conserved in bacteria
HL670_RS24990	COG0746	molybdenum cofactor guanylyltransferase activity
HL670_RS24995	COG1763	Mo-molybdopterin cofactor biosynthetic process
HL670_RS25020	COG2186	Transcriptional regulator
HL670_RS25025	COG0477	Major facilitator Superfamily
HL670_RS25030	COG1609	Transcriptional regulator
HL670_RS25035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL670_RS25045	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS25055	COG1869	D-ribose catabolic process
HL670_RS25060	COG3158	transport of potassium into the cell
HL670_RS25065	COG0714	Associated with various cellular activities
HL670_RS25070	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HL670_RS25075	COG2502	aspartate--ammonia ligase
HL670_RS25080	COG1522	sequence-specific DNA binding
HL670_RS25085	COG0716	FMN binding
HL670_RS25090	COG0445	tRNA wobble uridine modification
HL670_RS25095	COG0357	Ribosomal RNA small subunit methyltransferase G
HL670_RS25100	COG3312	ion transport
HL670_RS25115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HL670_RS25120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL670_RS25125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HL670_RS25130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HL670_RS25135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HL670_RS25140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HL670_RS25145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL670_RS25160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HL670_RS25165	COG0573	inorganic phosphate transmembrane transporter activity
HL670_RS25170	COG0581	inorganic phosphate transmembrane transporter activity
HL670_RS25185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL670_RS25195	COG0765	amino acid transport
HL670_RS25200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL670_RS25205	COG2252	PERMEase
HL670_RS25215	COG0431	NADPH-dependent FMN reductase
HL670_RS25220	COG2091	lysine biosynthetic process via aminoadipic acid
HL670_RS25230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HL670_RS25235	COG0706	membrane insertase activity
HL670_RS25240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HL670_RS25245	COG0594	ribonuclease P activity
HL670_RS25255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HL670_RS25260	COG0592	DNA-directed DNA polymerase activity
HL670_RS25265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HL670_RS25270	COG0187	DNA topoisomerase II activity
HL670_RS25275	COG0561	phosphatase activity
HL670_RS25280	COG2423	ornithine cyclodeaminase activity
HL670_RS25285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HL670_RS25290	COG0823	Involved in the tonB-independent uptake of proteins
HL670_RS25295	COG5645	(Lipo)protein
HL670_RS25300	COG0071	Belongs to the small heat shock protein (HSP20) family
HL670_RS25305	COG0071	Belongs to the small heat shock protein (HSP20) family
HL670_RS25315	COG3977	Valine--pyruvate aminotransferase
HL670_RS25320	COG0366	Alpha amylase catalytic
HL670_RS25325	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HL670_RS25335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL670_RS25345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL670_RS25355	COG1609	Transcriptional regulator
HL670_RS25360	COG2885	chlorophyll binding
HL670_RS25365	COG0456	acetyltransferase
HL670_RS25370	COG2818	Glycosylase
HL670_RS25380	COG2771	luxR family
HL670_RS25390	COG2271	Major facilitator Superfamily
HL670_RS25395	COG0752	glycyl-tRNA synthetase alpha subunit
HL670_RS25400	COG0751	glycine-tRNA ligase activity
HL670_RS25415	COG2213	PTS system mannitol-specific
HL670_RS25415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL670_RS25420	COG0246	Mannitol dehydrogenase
HL670_RS25425	COG3722	fumarate hydratase activity
HL670_RS25435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL670_RS25450	COG2258	MOSC domain
HL670_RS25460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HL670_RS25475	COG0437	4 iron, 4 sulfur cluster binding
HL670_RS25480	COG2864	formate dehydrogenase
HL670_RS25485	COG3058	Necessary for formate dehydrogenase activity
HL670_RS25495	COG0625	glutathione transferase activity
HL670_RS25500	COG1921	L-seryl-tRNASec selenium transferase activity
HL670_RS25505	COG3276	selenocysteine insertion sequence binding
HL670_RS25515	COG3274	enterobacterial common antigen metabolic process
HL670_RS25525	COG1335	isochorismatase
HL670_RS25530	COG0402	S-adenosylhomocysteine deaminase activity
HL670_RS25535	COG1070	Carbohydrate kinase
HL670_RS25540	COG2115	Belongs to the xylose isomerase family
HL670_RS25545	COG4213	ABC transporter substrate-binding protein
HL670_RS25550	COG1129	ABC transporter
HL670_RS25555	COG4214	carbohydrate transport
HL670_RS25560	COG2207	Transcriptional regulator
HL670_RS25560	COG1609	Transcriptional regulator
HL670_RS25565	COG0583	DNA-binding transcription factor activity
HL670_RS25570	COG2807	transmembrane transport
HL670_RS25640	COG1028	Short-chain dehydrogenase reductase Sdr
HL670_RS25665	COG1846	Transcriptional regulator
HL670_RS25670	COG1764	response to oxidative stress
HL670_RS25675	COG2194	sulfuric ester hydrolase activity
HL670_RS25680	COG2197	response regulator
HL670_RS25690	COG2271	Major facilitator Superfamily
HL670_RS25715	COG0747	negative chemotaxis
HL670_RS25720	COG0601	transmembrane transport
HL670_RS25725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL670_RS25730	COG0444	Belongs to the ABC transporter superfamily
HL670_RS25735	COG4608	Belongs to the ABC transporter superfamily
HL670_RS25740	COG2194	sulfuric ester hydrolase activity
HL670_RS25765	COG1215	transferase activity, transferring glycosyl groups
HL670_RS25770	COG1215	transferase activity, transferring glycosyl groups
HL670_RS25775	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HL670_RS25780	COG0457	Tetratricopeptide repeat
HL670_RS25780	COG3118	belongs to the thioredoxin family
HL670_RS25785	COG2200	EAL domain
HL670_RS25785	COG2199	diguanylate cyclase activity
HL670_RS25790	COG1301	dicarboxylic acid transport
HL670_RS25795	COG0612	Peptidase, M16
HL670_RS25800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL670_RS25810	COG0248	Ppx GppA phosphatase
HL670_RS25815	COG0513	Belongs to the DEAD box helicase family
HL670_RS25820	COG3118	belongs to the thioredoxin family
HL670_RS25825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HL670_RS25830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL670_RS25840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HL670_RS25845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HL670_RS25850	COG1088	dTDP-glucose 4,6-dehydratase activity
HL670_RS25855	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HL670_RS25860	COG0456	acetyltransferase
HL670_RS25865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HL670_RS25870	COG2244	polysaccharide biosynthetic process
HL670_RS25885	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HL670_RS25915	COG3071	HemY protein
HL670_RS25920	COG2959	enzyme of heme biosynthesis
HL670_RS25930	COG0181	hydroxymethylbilane synthase activity
HL670_RS25935	COG3072	Adenylate cyclase
HL670_RS25940	COG1965	Belongs to the frataxin family
HL670_RS25945	COG5567	small periplasmic lipoprotein
HL670_RS25950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL670_RS25955	COG3159	Protein conserved in bacteria
HL670_RS25965	COG1011	Hydrolase
HL670_RS25970	COG0210	DNA helicase
HL670_RS25985	COG3180	Ammonia monooxygenase
HL670_RS25995	COG2050	protein possibly involved in aromatic compounds catabolism
HL670_RS26000	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HL670_RS26010	COG1280	lysine exporter protein (LysE YggA)
HL670_RS26015	COG1280	lysine exporter protein (LysE YggA)
HL670_RS26025	COG0561	phosphatase activity
HL670_RS26030	COG0584	glycerophosphoryl diester phosphodiesterase
HL670_RS26035	COG2271	Major facilitator Superfamily
HL670_RS26040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HL670_RS26050	COG0247	lactate metabolic process
HL670_RS26065	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HL670_RS26070	COG0425	Belongs to the sulfur carrier protein TusA family
HL670_RS26075	COG2217	Heavy metal translocating P-type atpase
HL670_RS26090	COG3714	YhhN family
HL670_RS26100	COG3776	membrane
HL670_RS26105	COG0742	ribosomal rna small subunit methyltransferase
HL670_RS26110	COG0552	protein localization to endoplasmic reticulum
HL670_RS26115	COG2884	Cell division ATP-binding protein ftsE
HL670_RS26120	COG2177	Part of the ABC transporter FtsEX involved in
HL670_RS26140	COG0456	acetyltransferase
HL670_RS26150	COG0559	Belongs to the binding-protein-dependent transport system permease family
HL670_RS26155	COG4177	L-phenylalanine transmembrane transporter activity
HL670_RS26165	COG0410	ABC transporter
HL670_RS26170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL670_RS26175	COG1653	transport
HL670_RS26180	COG1175	transmembrane transport
HL670_RS26190	COG3842	ATPase activity
HL670_RS26195	COG0584	glycerophosphoryl diester phosphodiesterase
HL670_RS26235	COG0583	DNA-binding transcription factor activity
HL670_RS26240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HL670_RS26245	COG0412	Dienelactone hydrolase
HL670_RS26260	COG0586	Pfam SNARE associated Golgi protein
HL670_RS26265	COG1322	Protein conserved in bacteria
HL670_RS26270	COG2226	methyltransferase
HL670_RS26275	COG3165	ubiquinone biosynthetic process from chorismate
HL670_RS26280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HL670_RS26285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HL670_RS26295	COG0805	protein transport
HL670_RS26300	COG0084	hydrolase, TatD family'
HL670_RS26330	COG0183	Belongs to the thiolase family
HL670_RS26335	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL670_RS26335	COG1024	Enoyl-CoA hydratase
HL670_RS26340	COG2271	Major facilitator Superfamily
HL670_RS26345	COG0006	proline dipeptidase activity
HL670_RS26350	COG1739	Uncharacterized protein family UPF0029
HL670_RS26355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HL670_RS26400	COG1879	ABC-type sugar transport system periplasmic component
HL670_RS26405	COG1129	ABC transporter
HL670_RS26410	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS26415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL670_RS26420	COG0583	DNA-binding transcription factor activity
HL670_RS26425	COG3085	chromosome segregation
HL670_RS26435	COG2814	Major facilitator Superfamily
HL670_RS26450	COG3978	acetolactate synthase activity
HL670_RS26455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL670_RS26460	COG0129	dihydroxy-acid dehydratase activity
HL670_RS26465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HL670_RS26475	COG0583	DNA-binding transcription factor activity
HL670_RS26480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HL670_RS26485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL670_RS26490	COG1942	4-Oxalocrotonate Tautomerase