locus-tag	class	description
I6I95_RS00010	COG2814	Major facilitator Superfamily
I6I95_RS00015	COG1380	Effector of murein hydrolase LrgA
I6I95_RS00020	COG1346	cytolysis
I6I95_RS00025	COG0295	cytidine deaminase activity
I6I95_RS00030	COG0281	malic enzyme
I6I95_RS00035	COG2949	membrane
I6I95_RS00055	COG1609	Transcriptional regulator
I6I95_RS00060	COG2311	Membrane
I6I95_RS00065	COG0302	gtp cyclohydrolase
I6I95_RS00070	COG0477	Major facilitator Superfamily
I6I95_RS00075	COG0583	DNA-binding transcription factor activity
I6I95_RS00100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I95_RS00105	COG0601	transmembrane transport
I6I95_RS00110	COG0747	negative chemotaxis
I6I95_RS00115	COG4172	Belongs to the ABC transporter superfamily
I6I95_RS00120	COG1446	asparaginase
I6I95_RS00130	COG0303	'Molybdopterin
I6I95_RS00135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I95_RS00145	COG0488	(ABC) transporter
I6I95_RS00160	COG0583	DNA-binding transcription factor activity
I6I95_RS00185	COG0640	Transcriptional regulator
I6I95_RS00190	COG0625	glutathione transferase activity
I6I95_RS00205	COG1309	transcriptional regulator
I6I95_RS00210	COG0702	epimerase
I6I95_RS00215	COG0579	oxidoreductase
I6I95_RS00220	COG3708	Transcriptional regulator
I6I95_RS00220	COG2207	Transcriptional regulator
I6I95_RS00240	COG3539	Fimbrial protein
I6I95_RS00245	COG2200	EAL domain
I6I95_RS00255	COG0069	glutamate synthase activity
I6I95_RS00260	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I95_RS00265	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS00270	COG1309	transcriptional regulator
I6I95_RS00275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I95_RS00285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I95_RS00290	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6I95_RS00295	COG0745	RESPONSE REGULATOR receiver
I6I95_RS00300	COG5002	protein histidine kinase activity
I6I95_RS00320	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6I95_RS00325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I95_RS00330	COG3622	Belongs to the hyi family
I6I95_RS00340	COG0583	DNA-binding transcription factor activity
I6I95_RS00345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I95_RS00350	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I95_RS00360	COG2731	YhcH YjgK YiaL family protein
I6I95_RS00365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I95_RS00375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I95_RS00380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS00385	COG0765	amino acid transport
I6I95_RS00390	COG1126	abc transporter atp-binding protein
I6I95_RS00395	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6I95_RS00400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I95_RS00415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I95_RS00425	COG0477	Major facilitator Superfamily
I6I95_RS00435	COG1280	lysine exporter protein (LysE YggA)
I6I95_RS00440	COG0583	DNA-binding transcription factor activity
I6I95_RS00445	COG2814	Major facilitator Superfamily
I6I95_RS00450	COG0697	spore germination
I6I95_RS00455	COG1522	sequence-specific DNA binding
I6I95_RS00460	COG1199	ATP-dependent helicase activity
I6I95_RS00465	COG1942	4-Oxalocrotonate Tautomerase
I6I95_RS00470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I95_RS00485	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6I95_RS00535	COG0697	spore germination
I6I95_RS00545	COG0583	DNA-binding transcription factor activity
I6I95_RS00560	COG1174	glycine betaine transport
I6I95_RS00565	COG1125	glycine betaine transport
I6I95_RS00570	COG1174	glycine betaine transport
I6I95_RS00575	COG1732	Glycine betaine
I6I95_RS00595	COG0583	DNA-binding transcription factor activity
I6I95_RS00600	COG1335	isochorismatase
I6I95_RS00615	COG0625	glutathione transferase activity
I6I95_RS00625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I95_RS00640	COG1683	Conserved Protein
I6I95_RS00650	COG2897	thiosulfate sulfurtransferase activity
I6I95_RS00655	COG0583	DNA-binding transcription factor activity
I6I95_RS00685	COG3511	phospholipase C
I6I95_RS00720	COG1802	Transcriptional regulator
I6I95_RS00750	COG4807	Protein conserved in bacteria
I6I95_RS00765	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I95_RS00775	COG1063	alcohol dehydrogenase
I6I95_RS00780	COG1802	Transcriptional regulator
I6I95_RS00785	COG2271	Major facilitator Superfamily
I6I95_RS00795	COG0583	DNA-binding transcription factor activity
I6I95_RS00825	COG0583	DNA-binding transcription factor activity
I6I95_RS00830	COG0456	acetyltransferase
I6I95_RS00835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I95_RS00840	COG2011	ABC-type metal ion transport system permease component
I6I95_RS00845	COG1464	Belongs to the NlpA lipoprotein family
I6I95_RS00850	COG1309	transcriptional regulator
I6I95_RS00865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I95_RS00885	COG0366	Alpha amylase catalytic
I6I95_RS00910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I95_RS00915	COG1070	Carbohydrate kinase
I6I95_RS00925	COG0583	DNA-binding transcription factor activity
I6I95_RS00940	COG1192	Involved in chromosome partitioning
I6I95_RS00955	COG1120	ATPase activity
I6I95_RS00960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I95_RS00965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I95_RS00980	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I95_RS00990	COG0436	Aminotransferase
I6I95_RS01020	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I95_RS01035	COG0277	FAD linked oxidase domain protein
I6I95_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS01055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I95_RS01070	COG1464	Belongs to the NlpA lipoprotein family
I6I95_RS01085	COG0697	spore germination
I6I95_RS01095	COG2354	Protein conserved in bacteria
I6I95_RS01110	COG1686	Belongs to the peptidase S11 family
I6I95_RS01115	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I95_RS01120	COG4977	sequence-specific DNA binding
I6I95_RS01130	COG0586	Pfam SNARE associated Golgi protein
I6I95_RS01135	COG1280	lysine exporter protein (LysE YggA)
I6I95_RS01140	COG0583	DNA-binding transcription factor activity
I6I95_RS01160	COG0583	DNA-binding transcription factor activity
I6I95_RS01250	COG3121	Chaperone
I6I95_RS01255	COG3188	usher protein
I6I95_RS01280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I95_RS01285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I95_RS01290	COG0513	Belongs to the DEAD box helicase family
I6I95_RS01295	COG1309	transcriptional regulator
I6I95_RS01300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS01305	COG1131	(ABC) transporter
I6I95_RS01310	COG0842	Transport permease protein
I6I95_RS01315	COG0842	Transport permease protein
I6I95_RS01320	COG0670	Belongs to the BI1 family
I6I95_RS01325	COG0314	molybdopterin synthase activity
I6I95_RS01330	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6I95_RS01335	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I95_RS01340	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I95_RS01345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I95_RS01350	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I95_RS01355	COG4628	conserved protein (DUF2132)
I6I95_RS01360	COG0556	nucleotide-excision repair
I6I95_RS01380	COG0156	8-amino-7-oxononanoate synthase activity
I6I95_RS01385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I95_RS01400	COG1881	PFAM PEBP family protein
I6I95_RS01405	COG2706	6-phosphogluconolactonase activity
I6I95_RS01410	COG0561	phosphatase activity
I6I95_RS01420	COG4149	molybdate abc transporter
I6I95_RS01425	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I95_RS01435	COG3585	molybdate ion transport
I6I95_RS01435	COG2005	Transcriptional regulator
I6I95_RS01440	COG1119	ATPase activity
I6I95_RS01455	COG1085	galactose-1-phosphate uridylyltransferase
I6I95_RS01460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I95_RS01465	COG2017	converts alpha-aldose to the beta-anomer
I6I95_RS01475	COG0588	phosphoglycerate mutase activity
I6I95_RS01480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I95_RS01485	COG2197	response regulator
I6I95_RS01490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS01490	COG2205	protein histidine kinase activity
I6I95_RS01495	COG1230	cation diffusion facilitator family transporter
I6I95_RS01505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I95_RS01560	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6I95_RS01565	COG2885	chlorophyll binding
I6I95_RS01570	COG0823	Involved in the tonB-independent uptake of proteins
I6I95_RS01575	COG3064	Membrane
I6I95_RS01575	COG3064	Membrane
I6I95_RS01580	COG0848	biopolymer transport protein
I6I95_RS01585	COG0811	peptide transport
I6I95_RS01590	COG0824	Thioesterase
I6I95_RS01595	COG3790	cyd operon protein YbgE
I6I95_RS01600	COG4890	Cyd operon protein YbgT
I6I95_RS01605	COG1294	oxidase, subunit
I6I95_RS01610	COG1271	oxidase subunit
I6I95_RS01615	COG0737	Belongs to the 5'-nucleotidase family
I6I95_RS01620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I95_RS01625	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I95_RS01630	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I95_RS01635	COG0567	Dehydrogenase, E1 component
I6I95_RS01640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I95_RS01650	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I95_RS01665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I95_RS01685	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I95_RS01690	COG1984	allophanate hydrolase subunit 2
I6I95_RS01695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I95_RS01700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I95_RS01705	COG5212	phosphodiesterase
I6I95_RS01715	COG3272	Protein of unknown function (DUF1722)
I6I95_RS01730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I95_RS01735	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I95_RS01740	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I95_RS01745	COG2205	protein histidine kinase activity
I6I95_RS01750	COG0745	RESPONSE REGULATOR receiver
I6I95_RS01760	COG1695	Transcriptional regulator
I6I95_RS01765	COG0033	Phosphoglucomutase
I6I95_RS01770	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6I95_RS01775	COG0596	Alpha beta hydrolase
I6I95_RS01790	COG0735	belongs to the Fur family
I6I95_RS01805	COG2814	Major facilitator Superfamily
I6I95_RS01825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I95_RS01830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS01830	COG2190	(PTS) system
I6I95_RS01830	COG1263	PTS System
I6I95_RS01835	COG0363	glucosamine-6-phosphate deaminase activity
I6I95_RS01840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I95_RS01845	COG1846	Transcriptional regulator
I6I95_RS01845	COG1940	carbohydrate kinase activity
I6I95_RS01850	COG0647	UMP catabolic process
I6I95_RS01855	COG3469	chitinase activity
I6I95_RS01860	COG0367	asparagine synthase
I6I95_RS01895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I95_RS01900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I95_RS01905	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I95_RS01910	COG1702	phosphate starvation-inducible protein PhoH
I6I95_RS01915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I95_RS01920	COG4535	Mg2 and Co2 transporter CorC
I6I95_RS01925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I95_RS01935	COG0765	amino acid transport
I6I95_RS01940	COG0765	amino acid transport
I6I95_RS01945	COG1126	abc transporter atp-binding protein
I6I95_RS01950	COG1957	nucleoside hydrolase
I6I95_RS01960	COG2888	peptidyl-tyrosine sulfation
I6I95_RS01965	COG0495	leucyl-tRNA aminoacylation
I6I95_RS01970	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6I95_RS01975	COG1466	dna polymerase III delta subunit
I6I95_RS01980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I95_RS01985	COG0799	negative regulation of ribosome biogenesis
I6I95_RS01990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I95_RS01995	COG0768	penicillin binding
I6I95_RS02000	COG0772	Belongs to the SEDS family
I6I95_RS02005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I95_RS02010	COG1686	Belongs to the peptidase S11 family
I6I95_RS02015	COG2921	Belongs to the UPF0250 family
I6I95_RS02020	COG0321	lipoyl(octanoyl) transferase activity
I6I95_RS02025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I95_RS02035	COG3706	GGDEF domain
I6I95_RS02045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I95_RS02055	COG2814	Major facilitator Superfamily
I6I95_RS02065	COG1473	amidohydrolase
I6I95_RS02070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS02080	COG0765	amino acid transport
I6I95_RS02085	COG1126	abc transporter atp-binding protein
I6I95_RS02095	COG1278	Cold shock
I6I95_RS02105	COG2199	diguanylate cyclase activity
I6I95_RS02120	COG0667	Aldo Keto reductase
I6I95_RS02285	COG3121	Chaperone
I6I95_RS02290	COG3188	usher protein
I6I95_RS02360	COG0582	viral genome integration into host DNA
I6I95_RS02365	COG0582	viral genome integration into host DNA
I6I95_RS02385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I95_RS02390	COG2501	S4 domain
I6I95_RS02395	COG0215	cysteine-tRNA ligase activity
I6I95_RS02400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I95_RS02405	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I95_RS02410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I95_RS02415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I95_RS02425	COG2814	Major facilitator Superfamily
I6I95_RS02430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I95_RS02435	COG4181	ATPase activity
I6I95_RS02440	COG2755	lipolytic protein G-D-S-L family
I6I95_RS02445	COG0300	oxidoreductase activity
I6I95_RS02450	COG3118	belongs to the thioredoxin family
I6I95_RS02455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I95_RS02460	COG0549	Belongs to the carbamate kinase family
I6I95_RS02470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I95_RS02475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I95_RS02480	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I95_RS02485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I95_RS02495	COG3257	ureidoglycine aminohydrolase activity
I6I95_RS02500	COG1929	Belongs to the glycerate kinase type-1 family
I6I95_RS02505	COG2271	Major facilitator Superfamily
I6I95_RS02510	COG2084	Dehydrogenase
I6I95_RS02515	COG3622	Belongs to the hyi family
I6I95_RS02520	COG3960	tartronate-semialdehyde synthase activity
I6I95_RS02540	COG0330	HflC and HflK could
I6I95_RS02545	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I95_RS02550	COG0789	Transcriptional regulator
I6I95_RS02555	COG2217	Heavy metal translocating P-type atpase
I6I95_RS02560	COG3735	TraB family
I6I95_RS02565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I95_RS02570	COG0737	Belongs to the 5'-nucleotidase family
I6I95_RS02575	COG2223	nitrite transmembrane transporter activity
I6I95_RS02580	COG4651	solute:proton antiporter activity
I6I95_RS02580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I95_RS02590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I95_RS02595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I95_RS02600	COG0563	adenylate kinase activity
I6I95_RS02605	COG0326	Molecular chaperone. Has ATPase activity
I6I95_RS02610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I95_RS02620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I95_RS02625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I95_RS02630	COG2832	Protein of unknown function (DUF454)
I6I95_RS02645	COG3264	Mechanosensitive ion channel
I6I95_RS02645	COG1196	nuclear chromosome segregation
I6I95_RS02650	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I95_RS02655	COG1309	transcriptional regulator
I6I95_RS02660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS02665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I95_RS02670	COG0254	rRNA binding
I6I95_RS02675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I95_RS02680	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I95_RS02685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I95_RS02690	COG1121	(ABC) transporter
I6I95_RS02715	COG3397	chitin binding
I6I95_RS02750	COG2165	general secretion pathway protein
I6I95_RS02770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I95_RS02805	COG3695	enzyme binding
I6I95_RS02810	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6I95_RS02815	COG1946	Acyl-CoA thioesterase
I6I95_RS02820	COG0004	ammonium transporteR
I6I95_RS02825	COG0347	Belongs to the P(II) protein family
I6I95_RS02830	COG1132	(ABC) transporter
I6I95_RS02835	COG1132	(ABC) transporter
I6I95_RS02840	COG1522	sequence-specific DNA binding
I6I95_RS02850	COG0561	phosphatase activity
I6I95_RS02855	COG4533	DNA binding
I6I95_RS02860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I95_RS02865	COG0824	Thioesterase
I6I95_RS02870	COG1555	photosystem II stabilization
I6I95_RS02875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I95_RS02885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I95_RS02890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I95_RS02900	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I95_RS02905	COG0271	Belongs to the BolA IbaG family
I6I95_RS02910	COG3056	Lipoprotein
I6I95_RS02915	COG2223	nitrite transmembrane transporter activity
I6I95_RS02920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I95_RS02925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I95_RS02930	COG1845	cytochrome c oxidase, subunit III
I6I95_RS02935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I95_RS02940	COG0109	protoheme IX farnesyltransferase activity
I6I95_RS02945	COG2814	Major facilitator Superfamily
I6I95_RS02950	COG1666	GTP binding
I6I95_RS02955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I95_RS02960	COG0693	protein deglycase activity
I6I95_RS02965	COG0301	tRNA thio-modification
I6I95_RS02965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I95_RS02970	COG1722	exodeoxyribonuclease VII activity
I6I95_RS02975	COG0142	geranyltranstransferase activity
I6I95_RS02980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I95_RS02985	COG0667	Aldo Keto reductase
I6I95_RS02990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I95_RS02995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I95_RS03000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I95_RS03005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I95_RS03010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I95_RS03010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I95_RS03015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I95_RS03025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I95_RS03035	COG1862	Preprotein translocase
I6I95_RS03040	COG0343	queuine tRNA-ribosyltransferase activity
I6I95_RS03045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I95_RS03050	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6I95_RS03055	COG0450	alkyl hydroperoxide reductase
I6I95_RS03065	COG0366	Alpha amylase catalytic
I6I95_RS03070	COG0668	transmembrane transport
I6I95_RS03090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I95_RS03100	COG5002	protein histidine kinase activity
I6I95_RS03105	COG0745	RESPONSE REGULATOR receiver
I6I95_RS03110	COG0420	3'-5' exonuclease activity
I6I95_RS03115	COG0419	ATPase involved in DNA repair
I6I95_RS03135	COG1940	carbohydrate kinase activity
I6I95_RS03150	COG0191	fructose-bisphosphate aldolase activity
I6I95_RS03165	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS03170	COG1129	ABC transporter
I6I95_RS03180	COG2974	May be involved in recombination
I6I95_RS03190	COG3123	guanosine phosphorylase activity
I6I95_RS03215	COG0667	Aldo Keto reductase
I6I95_RS03220	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I95_RS03265	COG2226	methyltransferase
I6I95_RS03275	COG3416	Protein conserved in bacteria
I6I95_RS03290	COG3011	Protein conserved in bacteria
I6I95_RS03300	COG1335	isochorismatase
I6I95_RS03315	COG0346	lactoylglutathione lyase activity
I6I95_RS03320	COG1349	DNA-binding transcription factor activity
I6I95_RS03345	COG3961	Belongs to the TPP enzyme family
I6I95_RS03350	COG0583	DNA-binding transcription factor activity
I6I95_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS03390	COG2207	Transcriptional regulator
I6I95_RS03395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I95_RS03410	COG3391	amine dehydrogenase activity
I6I95_RS03415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I95_RS03420	COG1629	transport
I6I95_RS03420	COG4774	siderophore transport
I6I95_RS03425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I95_RS03430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I95_RS03430	COG2226	methyltransferase
I6I95_RS03430	COG3433	isochorismatase activity
I6I95_RS03440	COG0747	negative chemotaxis
I6I95_RS03445	COG3038	cytochrome b561
I6I95_RS03480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I95_RS03490	COG1073	alpha beta
I6I95_RS03495	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I95_RS03500	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I95_RS03505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I95_RS03510	COG0584	glycerophosphoryl diester phosphodiesterase
I6I95_RS03515	COG2991	Protein conserved in bacteria
I6I95_RS03520	COG1477	protein flavinylation
I6I95_RS03525	COG2871	sodium ion transport
I6I95_RS03530	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I95_RS03535	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I95_RS03540	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I95_RS03545	COG1805	sodium ion transport
I6I95_RS03550	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I95_RS03555	COG3034	peptidoglycan biosynthetic process
I6I95_RS03560	COG0121	glutamine amidotransferase
I6I95_RS03565	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I95_RS03570	COG1960	acyl-CoA dehydrogenase activity
I6I95_RS03585	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I6I95_RS03590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6I95_RS03595	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6I95_RS03600	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6I95_RS03605	COG0235	Class ii aldolase
I6I95_RS03610	COG0436	Aminotransferase
I6I95_RS03620	COG2233	PERMEase
I6I95_RS03640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I95_RS03645	COG1126	abc transporter atp-binding protein
I6I95_RS03650	COG0765	amino acid transport
I6I95_RS03740	COG1953	Uracil, thiamine, allantoin
I6I95_RS03750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I95_RS03755	COG0328	RNA-DNA hybrid ribonuclease activity
I6I95_RS03760	COG2226	methyltransferase
I6I95_RS03765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I95_RS03770	COG1388	LysM domain
I6I95_RS03770	COG0741	lytic transglycosylase activity
I6I95_RS03780	COG2814	Major facilitator Superfamily
I6I95_RS03785	COG0583	DNA-binding transcription factor activity
I6I95_RS03790	COG0656	L-ascorbic acid biosynthetic process
I6I95_RS03795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I95_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS03805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I95_RS03810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I95_RS03855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I95_RS03905	COG0542	response to heat
I6I95_RS03915	COG0564	pseudouridine synthase activity
I6I95_RS03920	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I95_RS03925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I95_RS03935	COG0077	Prephenate dehydratase
I6I95_RS03935	COG1605	Chorismate mutase
I6I95_RS03940	COG1605	Chorismate mutase
I6I95_RS03940	COG0287	Prephenate dehydrogenase
I6I95_RS03945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I95_RS03950	COG3137	Salt-induced outer membrane protein
I6I95_RS04025	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6I95_RS04075	COG0335	large ribosomal subunit rRNA binding
I6I95_RS04080	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I95_RS04085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I95_RS04090	COG0228	four-way junction DNA binding
I6I95_RS04095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I95_RS04100	COG4137	Cytochrome C assembly protein
I6I95_RS04105	COG4536	flavin adenine dinucleotide binding
I6I95_RS04110	COG1854	S-ribosylhomocysteine lyase activity
I6I95_RS04115	COG2918	glutathione biosynthetic process
I6I95_RS04120	COG1238	metal cluster binding
I6I95_RS04125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I95_RS04165	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I95_RS04170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I95_RS04175	COG2137	regulation of response to DNA damage stimulus
I6I95_RS04180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I95_RS04200	COG1917	Cupin 2, conserved barrel domain protein
I6I95_RS04200	COG2169	Transcriptional regulator
I6I95_RS04205	COG2723	6-phospho-beta-galactosidase activity
I6I95_RS04210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I95_RS04215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I95_RS04290	COG4974	Belongs to the 'phage' integrase family
I6I95_RS04295	COG2003	Belongs to the UPF0758 family
I6I95_RS04310	COG1396	sequence-specific DNA binding
I6I95_RS04330	COG0631	protein serine/threonine phosphatase activity
I6I95_RS04335	COG2815	serine threonine protein kinase
I6I95_RS04335	COG0515	serine threonine protein kinase
I6I95_RS04360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I95_RS04365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I95_RS04370	COG4942	peptidase
I6I95_RS04370	COG1388	LysM domain
I6I95_RS04375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I95_RS04380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I95_RS04385	COG0585	pseudouridine synthase activity
I6I95_RS04390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I95_RS04395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I95_RS04400	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6I95_RS04410	COG0765	amino acid transport
I6I95_RS04425	COG0529	Catalyzes the synthesis of activated sulfate
I6I95_RS04430	COG2895	sulfate adenylyltransferase (ATP) activity
I6I95_RS04435	COG0175	sulfate reduction
I6I95_RS04440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I95_RS04440	COG1648	precorrin-2 dehydrogenase activity
I6I95_RS04445	COG2234	aminopeptidase activity
I6I95_RS04450	COG0175	sulfate reduction
I6I95_RS04455	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I95_RS04460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I95_RS04465	COG0720	synthase
I6I95_RS04470	COG0602	queuosine metabolic process
I6I95_RS04475	COG2271	Major facilitator Superfamily
I6I95_RS04480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I95_RS04485	COG2986	histidine ammonia-lyase
I6I95_RS04515	COG0504	CTP synthase activity
I6I95_RS04520	COG3956	TIGRFAM MazG family protein
I6I95_RS04525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I95_RS04540	COG1929	Belongs to the glycerate kinase type-1 family
I6I95_RS04545	COG2084	Dehydrogenase
I6I95_RS04550	COG3836	Belongs to the HpcH HpaI aldolase family
I6I95_RS04555	COG4948	Mandelate Racemase Muconate Lactonizing
I6I95_RS04560	COG4948	Mandelate Racemase Muconate Lactonizing
I6I95_RS04565	COG2271	Major facilitator Superfamily
I6I95_RS04570	COG2721	sulfolactate sulfo-lyase activity
I6I95_RS04575	COG3835	regulator
I6I95_RS04580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I95_RS04585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I95_RS04590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I95_RS04600	COG2860	membrane
I6I95_RS04605	COG0316	Belongs to the HesB IscA family
I6I95_RS04615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I95_RS04620	COG3725	Membrane protein required for beta-lactamase induction
I6I95_RS04625	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I95_RS04635	COG4969	Belongs to the N-Me-Phe pilin family
I6I95_RS04640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I95_RS04645	COG1459	type II secretion system
I6I95_RS04650	COG0516	GMP reductase activity
I6I95_RS04655	COG0237	dephospho-CoA kinase activity
I6I95_RS04660	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6I95_RS04665	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I95_RS04670	COG0494	nUDIX hydrolase
I6I95_RS04675	COG0653	protein targeting
I6I95_RS04695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I95_RS04700	COG0849	cell division
I6I95_RS04705	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I95_RS04710	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I95_RS04715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I95_RS04720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I95_RS04725	COG0772	Belongs to the SEDS family
I6I95_RS04735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I95_RS04740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I95_RS04745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I95_RS04750	COG0768	penicillin binding
I6I95_RS04755	COG3116	cell division
I6I95_RS04760	COG0275	rRNA processing
I6I95_RS04765	COG2001	Belongs to the MraZ family
I6I95_RS04785	COG0028	Belongs to the TPP enzyme family
I6I95_RS04790	COG1022	Amp-dependent synthetase and ligase
I6I95_RS04805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I95_RS04810	COG0473	3-isopropylmalate dehydrogenase activity
I6I95_RS04815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I95_RS04820	COG0066	3-isopropylmalate dehydratase activity
I6I95_RS04825	COG0471	metal ion transport
I6I95_RS04830	COG2814	Major facilitator Superfamily
I6I95_RS04845	COG4143	(ABC) transporter
I6I95_RS04850	COG1178	ABC-type Fe3 transport system permease component
I6I95_RS04865	COG0028	Belongs to the TPP enzyme family
I6I95_RS04870	COG0440	acetolactate synthase activity
I6I95_RS04875	COG0586	Pfam SNARE associated Golgi protein
I6I95_RS04880	COG0417	DNA replication proofreading
I6I95_RS04885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I95_RS04890	COG0564	pseudouridine synthase activity
I6I95_RS04900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I95_RS04910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I95_RS04915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I95_RS04920	COG2967	ApaG domain
I6I95_RS04925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I95_RS04935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I95_RS04945	COG2966	Psort location CytoplasmicMembrane, score
I6I95_RS04955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I95_RS04955	COG0475	glutathione-regulated potassium exporter activity
I6I95_RS04965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I95_RS04970	COG0505	Belongs to the CarA family
I6I95_RS04975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I95_RS05000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I95_RS05005	COG1047	Peptidyl-prolyl cis-trans
I6I95_RS05010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I95_RS05015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I95_RS05020	COG0196	riboflavin kinase activity
I6I95_RS05025	COG0268	Binds directly to 16S ribosomal RNA
I6I95_RS05030	COG0583	DNA-binding transcription factor activity
I6I95_RS05035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I95_RS05040	COG0484	heat shock protein binding
I6I95_RS05045	COG0443	Heat shock 70 kDa protein
I6I95_RS05050	COG1584	GPR1 FUN34 yaaH family protein
I6I95_RS05060	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I95_RS05065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I95_RS05070	COG1115	amino acid carrier protein
I6I95_RS05075	COG3022	response to hydroperoxide
I6I95_RS05085	COG0083	homoserine kinase activity
I6I95_RS05105	COG0745	RESPONSE REGULATOR receiver
I6I95_RS05110	COG3045	CreA protein
I6I95_RS05115	COG2207	Transcriptional regulator
I6I95_RS05115	COG3708	Transcriptional regulator
I6I95_RS05120	COG0406	alpha-ribazole phosphatase activity
I6I95_RS05125	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6I95_RS05130	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6I95_RS05135	COG0741	lytic transglycosylase activity
I6I95_RS05145	COG2199	diguanylate cyclase activity
I6I95_RS05150	COG2885	chlorophyll binding
I6I95_RS05155	COG0488	(ABC) transporter
I6I95_RS05165	COG0604	alcohol dehydrogenase
I6I95_RS05180	COG0560	Phosphoserine phosphatase
I6I95_RS05185	COG3726	membrane protein affecting hemolysin expression
I6I95_RS05190	COG3550	peptidyl-serine autophosphorylation
I6I95_RS05200	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I95_RS05205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I95_RS05210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I95_RS05215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I95_RS05220	COG0084	hydrolase, TatD family'
I6I95_RS05225	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I95_RS05230	COG3237	CsbD-like
I6I95_RS05235	COG5487	UPF0391 membrane protein
I6I95_RS05240	COG2823	Periplasmic or secreted lipoprotein
I6I95_RS05245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I95_RS05250	COG3550	peptidyl-serine autophosphorylation
I6I95_RS05265	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6I95_RS05270	COG2813	Specifically methylates the guanine in position
I6I95_RS05275	COG0667	Aldo Keto reductase
I6I95_RS05305	COG3706	GGDEF domain
I6I95_RS05310	COG1309	transcriptional regulator
I6I95_RS05325	COG2814	Major facilitator Superfamily
I6I95_RS05330	COG0738	Major facilitator superfamily
I6I95_RS05335	COG3254	rhamnose metabolic process
I6I95_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS05345	COG3618	amidohydrolase
I6I95_RS05350	COG4948	Mandelate Racemase Muconate Lactonizing
I6I95_RS05355	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I95_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS05370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I95_RS05375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I95_RS05380	COG2368	4-hydroxyphenylacetate
I6I95_RS05400	COG3971	2-oxopent-4-enoate hydratase activity
I6I95_RS05415	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS05430	COG1846	Transcriptional regulator
I6I95_RS05455	COG1113	amino acid transport
I6I95_RS05475	COG2267	carboxylic ester hydrolase activity
I6I95_RS05485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I95_RS05495	COG1454	alcohol dehydrogenase
I6I95_RS05530	COG0811	peptide transport
I6I95_RS05560	COG1376	ErfK ybiS ycfS ynhG family protein
I6I95_RS05565	COG2207	Transcriptional regulator
I6I95_RS05565	COG3708	Transcriptional regulator
I6I95_RS05570	COG2207	Transcriptional regulator
I6I95_RS05575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I95_RS05585	COG0318	PFAM AMP-dependent synthetase and ligase
I6I95_RS05615	COG2814	Major facilitator Superfamily
I6I95_RS05620	COG3391	amine dehydrogenase activity
I6I95_RS05640	COG0174	glutamine synthetase
I6I95_RS05665	COG1966	Carbon starvation protein
I6I95_RS05670	COG2879	small protein
I6I95_RS05675	COG0523	cobalamin synthesis protein
I6I95_RS05690	COG1609	Transcriptional regulator
I6I95_RS05695	COG1263	PTS System
I6I95_RS05695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS05700	COG2723	6-phospho-beta-galactosidase activity
I6I95_RS05715	COG1002	Type II restriction enzyme, methylase subunits
I6I95_RS05720	COG1061	Type III restriction enzyme res subunit
I6I95_RS05725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I95_RS05730	COG3550	peptidyl-serine autophosphorylation
I6I95_RS05780	COG0795	lipopolysaccharide-transporting ATPase activity
I6I95_RS05785	COG0795	lipopolysaccharide-transporting ATPase activity
I6I95_RS05790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I95_RS05795	COG2927	DNA polymerase III (CHI subunit)
I6I95_RS05805	COG0456	acetyltransferase
I6I95_RS05815	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I95_RS05825	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6I95_RS05830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I95_RS05840	COG0540	Belongs to the ATCase OTCase family
I6I95_RS05855	COG2308	Evidence 4 Homologs of previously reported genes of
I6I95_RS05880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I95_RS05885	COG1609	Transcriptional regulator
I6I95_RS05930	COG1263	PTS System
I6I95_RS05930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS05935	COG0366	Alpha amylase catalytic
I6I95_RS05940	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I95_RS05945	COG0583	DNA-binding transcription factor activity
I6I95_RS05960	COG0701	Predicted permease
I6I95_RS05965	COG2188	Transcriptional regulator
I6I95_RS05970	COG3624	Phosphonate C-P lyase system protein PhnG
I6I95_RS05975	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I95_RS05980	COG3626	phosphonate metabolism
I6I95_RS05985	COG3627	carbon phosphorus lyase activity
I6I95_RS05990	COG4107	phosphonate C-P lyase system protein PhnK
I6I95_RS05995	COG4778	phosphonate C-P lyase system protein PhnL
I6I95_RS06000	COG3454	Phosphonate metabolism
I6I95_RS06005	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I95_RS06015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I95_RS06020	COG0702	epimerase
I6I95_RS06025	COG3787	Belongs to the UPF0306 family
I6I95_RS06035	COG2827	Endonuclease containing a URI domain
I6I95_RS06040	COG3153	acetyltransferase
I6I95_RS06045	COG3154	lipid carrier protein
I6I95_RS06050	COG0826	peptidase U32
I6I95_RS06055	COG0826	peptidase U32
I6I95_RS06090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS06095	COG0477	Major facilitator Superfamily
I6I95_RS06105	COG0425	Belongs to the sulfur carrier protein TusA family
I6I95_RS06110	COG2391	methyltransferase activity
I6I95_RS06115	COG0513	Belongs to the DEAD box helicase family
I6I95_RS06130	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I95_RS06135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I95_RS06140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I95_RS06145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I95_RS06150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I95_RS06155	COG0195	Participates in both transcription termination and antitermination
I6I95_RS06160	COG0779	Required for maturation of 30S ribosomal subunits
I6I95_RS06175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I95_RS06180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I95_RS06185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I95_RS06195	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I95_RS06200	COG1534	Rna-binding protein
I6I95_RS06210	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I95_RS06215	COG0745	RESPONSE REGULATOR receiver
I6I95_RS06220	COG0642	Histidine kinase
I6I95_RS06225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I95_RS06230	COG0697	spore germination
I6I95_RS06235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I95_RS06240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I95_RS06245	COG0142	geranyltranstransferase activity
I6I95_RS06255	COG3423	Transcriptional regulator
I6I95_RS06260	COG0039	L-malate dehydrogenase activity
I6I95_RS06265	COG1438	arginine binding
I6I95_RS06280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I95_RS06285	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I95_RS06290	COG0840	transmembrane signaling receptor activity
I6I95_RS06295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I95_RS06300	COG2105	PFAM AIG2 family protein
I6I95_RS06305	COG2911	Protein conserved in bacteria
I6I95_RS06310	COG0729	surface antigen
I6I95_RS06315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I95_RS06320	COG1253	flavin adenine dinucleotide binding
I6I95_RS06330	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6I95_RS06335	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I95_RS06340	COG0737	Belongs to the 5'-nucleotidase family
I6I95_RS06350	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I95_RS06355	COG3061	Opacity-associated protein A
I6I95_RS06365	COG0359	binds to the 23S rRNA
I6I95_RS06370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I95_RS06380	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I95_RS06390	COG1073	alpha beta
I6I95_RS06395	COG3650	response to hydrogen peroxide
I6I95_RS06405	COG3766	membrane
I6I95_RS06410	COG1960	acyl-CoA dehydrogenase activity
I6I95_RS06415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I95_RS06420	COG0557	exoribonuclease II activity
I6I95_RS06425	COG1959	2 iron, 2 sulfur cluster binding
I6I95_RS06430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I95_RS06435	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6I95_RS06440	COG0330	HflC and HflK could
I6I95_RS06445	COG0330	HflC and HflK could
I6I95_RS06450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I95_RS06455	COG1923	regulation of RNA biosynthetic process
I6I95_RS06460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I95_RS06465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I95_RS06470	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I95_RS06475	COG0802	atpase or kinase
I6I95_RS06480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I95_RS06480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I95_RS06485	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I95_RS06505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I95_RS06510	COG1162	GTPase activity
I6I95_RS06515	COG0688	phosphatidylethanolamine metabolic process
I6I95_RS06520	COG1511	domain protein
I6I95_RS06520	COG3264	Mechanosensitive ion channel
I6I95_RS06525	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6I95_RS06530	COG1053	succinate dehydrogenase
I6I95_RS06535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I95_RS06540	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I95_RS06545	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I95_RS06560	COG5510	response to toxic substance
I6I95_RS06565	COG5510	response to toxic substance
I6I95_RS06570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I95_RS06590	COG0459	protein refolding
I6I95_RS06595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I95_RS06610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I95_RS06620	COG4232	protein-disulfide reductase activity
I6I95_RS06625	COG1309	transcriptional regulator
I6I95_RS06635	COG1473	amidohydrolase
I6I95_RS06640	COG0700	Nucleoside recognition
I6I95_RS06645	COG3366	ferrous iron transmembrane transporter activity
I6I95_RS06650	COG0583	DNA-binding transcription factor activity
I6I95_RS06655	COG0659	secondary active sulfate transmembrane transporter activity
I6I95_RS06660	COG0288	reversible hydration of carbon dioxide
I6I95_RS06670	COG1301	dicarboxylic acid transport
I6I95_RS06675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I95_RS06680	COG3162	membrane
I6I95_RS06685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I95_RS06720	COG0138	bifunctional purine biosynthesis protein purh
I6I95_RS06725	COG0151	Belongs to the GarS family
I6I95_RS06745	COG1515	deoxyribonuclease V activity
I6I95_RS06750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I95_RS06755	COG2816	NAD+ diphosphatase activity
I6I95_RS06760	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6I95_RS06770	COG0352	thiamine-phosphate diphosphorylase activity
I6I95_RS06775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I95_RS06780	COG2104	thiamine diphosphate biosynthetic process
I6I95_RS06785	COG2022	thiamine diphosphate biosynthetic process
I6I95_RS06800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I95_RS06805	COG0085	RNA polymerase activity
I6I95_RS06810	COG0222	ribosome binding
I6I95_RS06815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I95_RS06820	COG0081	regulation of translation
I6I95_RS06825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I95_RS06830	COG0250	Participates in transcription elongation, termination and antitermination
I6I95_RS06840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I95_RS06875	COG1072	(Pantothenic acid kinase))
I6I95_RS06880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I95_RS06880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I95_RS06885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I95_RS06915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I95_RS06920	COG1739	Uncharacterized protein family UPF0029
I6I95_RS06925	COG0006	proline dipeptidase activity
I6I95_RS06930	COG2271	Major facilitator Superfamily
I6I95_RS06935	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I95_RS06935	COG1024	Enoyl-CoA hydratase
I6I95_RS06940	COG0183	Belongs to the thiolase family
I6I95_RS06970	COG0084	hydrolase, TatD family'
I6I95_RS06975	COG0805	protein transport
I6I95_RS06985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I95_RS06990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I95_RS06995	COG3165	ubiquinone biosynthetic process from chorismate
I6I95_RS07000	COG2226	methyltransferase
I6I95_RS07005	COG1322	Protein conserved in bacteria
I6I95_RS07010	COG0586	Pfam SNARE associated Golgi protein
I6I95_RS07025	COG0412	Dienelactone hydrolase
I6I95_RS07030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I95_RS07035	COG0583	DNA-binding transcription factor activity
I6I95_RS07055	COG0584	glycerophosphoryl diester phosphodiesterase
I6I95_RS07060	COG3842	ATPase activity
I6I95_RS07070	COG1175	transmembrane transport
I6I95_RS07075	COG1653	transport
I6I95_RS07080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I95_RS07085	COG0410	ABC transporter
I6I95_RS07095	COG4177	L-phenylalanine transmembrane transporter activity
I6I95_RS07100	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS07110	COG0456	acetyltransferase
I6I95_RS07130	COG2177	Part of the ABC transporter FtsEX involved in
I6I95_RS07135	COG2884	Cell division ATP-binding protein ftsE
I6I95_RS07140	COG0552	protein localization to endoplasmic reticulum
I6I95_RS07145	COG0742	ribosomal rna small subunit methyltransferase
I6I95_RS07150	COG3776	membrane
I6I95_RS07160	COG3714	YhhN family
I6I95_RS07175	COG2217	Heavy metal translocating P-type atpase
I6I95_RS07180	COG0425	Belongs to the sulfur carrier protein TusA family
I6I95_RS07185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I95_RS07200	COG0247	lactate metabolic process
I6I95_RS07210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I95_RS07215	COG2271	Major facilitator Superfamily
I6I95_RS07220	COG0584	glycerophosphoryl diester phosphodiesterase
I6I95_RS07225	COG0561	phosphatase activity
I6I95_RS07230	COG2267	carboxylic ester hydrolase activity
I6I95_RS07235	COG1280	lysine exporter protein (LysE YggA)
I6I95_RS07240	COG1280	lysine exporter protein (LysE YggA)
I6I95_RS07250	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6I95_RS07255	COG2050	protein possibly involved in aromatic compounds catabolism
I6I95_RS07265	COG3180	Ammonia monooxygenase
I6I95_RS07280	COG0210	DNA helicase
I6I95_RS07285	COG1011	Hydrolase
I6I95_RS07295	COG3159	Protein conserved in bacteria
I6I95_RS07300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I95_RS07305	COG5567	small periplasmic lipoprotein
I6I95_RS07310	COG1965	Belongs to the frataxin family
I6I95_RS07315	COG3072	Adenylate cyclase
I6I95_RS07320	COG0181	hydroxymethylbilane synthase activity
I6I95_RS07330	COG2959	enzyme of heme biosynthesis
I6I95_RS07335	COG3071	HemY protein
I6I95_RS07365	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6I95_RS07375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I95_RS07380	COG2244	polysaccharide biosynthetic process
I6I95_RS07385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I95_RS07390	COG0456	acetyltransferase
I6I95_RS07395	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I95_RS07400	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I95_RS07405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I95_RS07410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I95_RS07420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I95_RS07425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I95_RS07430	COG3118	belongs to the thioredoxin family
I6I95_RS07435	COG0513	Belongs to the DEAD box helicase family
I6I95_RS07440	COG0248	Ppx GppA phosphatase
I6I95_RS07450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I95_RS07455	COG0612	Peptidase, M16
I6I95_RS07460	COG1301	dicarboxylic acid transport
I6I95_RS07465	COG2199	diguanylate cyclase activity
I6I95_RS07465	COG2200	EAL domain
I6I95_RS07470	COG0457	Tetratricopeptide repeat
I6I95_RS07470	COG3118	belongs to the thioredoxin family
I6I95_RS07475	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6I95_RS07480	COG1215	transferase activity, transferring glycosyl groups
I6I95_RS07485	COG1215	transferase activity, transferring glycosyl groups
I6I95_RS07510	COG2194	sulfuric ester hydrolase activity
I6I95_RS07515	COG4608	Belongs to the ABC transporter superfamily
I6I95_RS07520	COG0444	Belongs to the ABC transporter superfamily
I6I95_RS07525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I95_RS07530	COG0601	transmembrane transport
I6I95_RS07535	COG0747	negative chemotaxis
I6I95_RS07560	COG2271	Major facilitator Superfamily
I6I95_RS07570	COG2197	response regulator
I6I95_RS07575	COG2194	sulfuric ester hydrolase activity
I6I95_RS07580	COG1764	response to oxidative stress
I6I95_RS07585	COG1846	Transcriptional regulator
I6I95_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS07630	COG0583	DNA-binding transcription factor activity
I6I95_RS07635	COG2814	Major facilitator Superfamily
I6I95_RS07670	COG3447	MASE1 domain protein
I6I95_RS07670	COG5001	Diguanylate cyclase
I6I95_RS07670	COG5002	protein histidine kinase activity
I6I95_RS07700	COG2807	transmembrane transport
I6I95_RS07705	COG0583	DNA-binding transcription factor activity
I6I95_RS07710	COG2207	Transcriptional regulator
I6I95_RS07710	COG1609	Transcriptional regulator
I6I95_RS07715	COG4214	carbohydrate transport
I6I95_RS07720	COG1129	ABC transporter
I6I95_RS07725	COG4213	ABC transporter substrate-binding protein
I6I95_RS07730	COG2115	Belongs to the xylose isomerase family
I6I95_RS07735	COG1070	Carbohydrate kinase
I6I95_RS07740	COG0402	S-adenosylhomocysteine deaminase activity
I6I95_RS07745	COG1335	isochorismatase
I6I95_RS07755	COG3274	enterobacterial common antigen metabolic process
I6I95_RS07765	COG3276	selenocysteine insertion sequence binding
I6I95_RS07770	COG1921	L-seryl-tRNASec selenium transferase activity
I6I95_RS07775	COG0625	glutathione transferase activity
I6I95_RS07785	COG3058	Necessary for formate dehydrogenase activity
I6I95_RS07790	COG2864	formate dehydrogenase
I6I95_RS07795	COG0437	4 iron, 4 sulfur cluster binding
I6I95_RS07810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I95_RS07820	COG2258	MOSC domain
I6I95_RS07835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I95_RS07845	COG3722	fumarate hydratase activity
I6I95_RS07850	COG0246	Mannitol dehydrogenase
I6I95_RS07855	COG2213	PTS system mannitol-specific
I6I95_RS07855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I95_RS07870	COG0751	glycine-tRNA ligase activity
I6I95_RS07875	COG0752	glycyl-tRNA synthetase alpha subunit
I6I95_RS07880	COG2271	Major facilitator Superfamily
I6I95_RS07890	COG2771	luxR family
I6I95_RS07900	COG2818	Glycosylase
I6I95_RS07905	COG0456	acetyltransferase
I6I95_RS07910	COG2885	chlorophyll binding
I6I95_RS07915	COG1609	Transcriptional regulator
I6I95_RS07925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I95_RS07930	COG2271	Major facilitator Superfamily
I6I95_RS07935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I95_RS07940	COG0366	Alpha amylase catalytic
I6I95_RS07945	COG3977	Valine--pyruvate aminotransferase
I6I95_RS07950	COG2985	domain, Protein
I6I95_RS07955	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I95_RS07960	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I95_RS07965	COG5645	(Lipo)protein
I6I95_RS07970	COG0823	Involved in the tonB-independent uptake of proteins
I6I95_RS07975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I95_RS07980	COG2423	ornithine cyclodeaminase activity
I6I95_RS07985	COG0561	phosphatase activity
I6I95_RS07990	COG0187	DNA topoisomerase II activity
I6I95_RS07995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I95_RS08000	COG0592	DNA-directed DNA polymerase activity
I6I95_RS08005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I95_RS08015	COG0594	ribonuclease P activity
I6I95_RS08020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I95_RS08025	COG0706	membrane insertase activity
I6I95_RS08030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I95_RS08040	COG2091	lysine biosynthetic process via aminoadipic acid
I6I95_RS08045	COG0431	NADPH-dependent FMN reductase
I6I95_RS08055	COG2252	PERMEase
I6I95_RS08060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I95_RS08065	COG0765	amino acid transport
I6I95_RS08070	COG0765	amino acid transport
I6I95_RS08075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS08090	COG0581	inorganic phosphate transmembrane transporter activity
I6I95_RS08095	COG0573	inorganic phosphate transmembrane transporter activity
I6I95_RS08100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I95_RS08115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I95_RS08120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I95_RS08125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I95_RS08130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I95_RS08135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I95_RS08140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I95_RS08145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I95_RS08160	COG3312	ion transport
I6I95_RS08165	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I95_RS08170	COG0445	tRNA wobble uridine modification
I6I95_RS08175	COG0716	FMN binding
I6I95_RS08180	COG1522	sequence-specific DNA binding
I6I95_RS08185	COG2502	aspartate--ammonia ligase
I6I95_RS08190	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6I95_RS08195	COG0714	Associated with various cellular activities
I6I95_RS08200	COG3158	transport of potassium into the cell
I6I95_RS08205	COG1869	D-ribose catabolic process
I6I95_RS08210	COG1129	ABC transporter
I6I95_RS08215	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS08225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I95_RS08230	COG1609	Transcriptional regulator
I6I95_RS08235	COG0477	Major facilitator Superfamily
I6I95_RS08240	COG2186	Transcriptional regulator
I6I95_RS08265	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I95_RS08270	COG0746	molybdenum cofactor guanylyltransferase activity
I6I95_RS08275	COG3084	Protein conserved in bacteria
I6I95_RS08280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I95_RS08285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I95_RS08290	COG0204	Acyl-transferase
I6I95_RS08295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I95_RS08295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I95_RS08300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I95_RS08305	COG3078	GTPase activator activity
I6I95_RS08325	COG3852	Histidine kinase
I6I95_RS08340	COG1011	Hydrolase
I6I95_RS08345	COG1295	ribonuclease BN
I6I95_RS08350	COG1490	D-aminoacyl-tRNA deacylase activity
I6I95_RS08355	COG0456	acetyltransferase
I6I95_RS08360	COG2982	Protein involved in outer membrane biogenesis
I6I95_RS08365	COG2233	PERMEase
I6I95_RS08370	COG0786	glutamate:sodium symporter activity
I6I95_RS08375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I95_RS08380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I95_RS08385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I95_RS08390	COG1758	RNA polymerase activity
I6I95_RS08395	COG0194	GDP metabolic process
I6I95_RS08410	COG0583	DNA-binding transcription factor activity
I6I95_RS08415	COG2860	membrane
I6I95_RS08425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I95_RS08435	COG1561	YicC-like family, N-terminal region
I6I95_RS08440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I95_RS08445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I95_RS08450	COG1309	transcriptional regulator
I6I95_RS08455	COG0756	dUTP diphosphatase activity
I6I95_RS08460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I95_RS08465	COG2003	Belongs to the UPF0758 family
I6I95_RS08470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I95_RS08480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I95_RS08495	COG1519	Transferase
I6I95_RS08505	COG0438	transferase activity, transferring glycosyl groups
I6I95_RS08510	COG0438	transferase activity, transferring glycosyl groups
I6I95_RS08515	COG0859	PFAM glycosyl transferase family 9
I6I95_RS08530	COG1216	Glycosyl transferase, family 2
I6I95_RS08530	COG1442	glycosyl transferase family 8
I6I95_RS08535	COG3307	-O-antigen
I6I95_RS08540	COG0438	transferase activity, transferring glycosyl groups
I6I95_RS08545	COG0859	PFAM glycosyl transferase family 9
I6I95_RS08550	COG0859	PFAM glycosyl transferase family 9
I6I95_RS08555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I95_RS08560	COG0156	8-amino-7-oxononanoate synthase activity
I6I95_RS08565	COG1063	alcohol dehydrogenase
I6I95_RS08570	COG2861	carbohydrate metabolic process
I6I95_RS08575	COG4942	peptidase
I6I95_RS08580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I95_RS08585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I95_RS08590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I95_RS08600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I95_RS08605	COG1045	serine acetyltransferase
I6I95_RS08620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I95_RS08625	COG2205	protein histidine kinase activity
I6I95_RS08630	COG0745	RESPONSE REGULATOR receiver
I6I95_RS08635	COG3678	ATP-independent chaperone mediated protein folding
I6I95_RS08640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I95_RS08645	COG0205	6-phosphofructokinase activity
I6I95_RS08650	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I95_RS08655	COG0149	triose-phosphate isomerase activity
I6I95_RS08665	COG3152	Membrane
I6I95_RS08680	COG2814	Major facilitator Superfamily
I6I95_RS08685	COG1494	fructose-1,6-bisphosphatase
I6I95_RS08695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I95_RS08700	COG3074	FtsZ-dependent cytokinesis
I6I95_RS08705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I95_RS08710	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I95_RS08715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I95_RS08720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I95_RS08725	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I95_RS08730	COG1609	Transcriptional regulator
I6I95_RS08735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I95_RS08740	COG0254	rRNA binding
I6I95_RS08745	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6I95_RS08750	COG0626	cystathionine gamma-synthase activity
I6I95_RS08755	COG0527	aspartate kinase activity
I6I95_RS08755	COG0460	homoserine dehydrogenase
I6I95_RS08775	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I95_RS08790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I95_RS08795	COG0137	argininosuccinate synthase activity
I6I95_RS08800	COG0165	Argininosuccinate lyase
I6I95_RS08805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I95_RS08810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I95_RS08810	COG0678	peroxiredoxin activity
I6I95_RS08820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I95_RS08835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I95_RS08840	COG4206	TonB-dependent receptor
I6I95_RS08845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I95_RS08885	COG1879	ABC-type sugar transport system periplasmic component
I6I95_RS08890	COG1129	ABC transporter
I6I95_RS08895	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS08900	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS08905	COG0583	DNA-binding transcription factor activity
I6I95_RS08910	COG3085	chromosome segregation
I6I95_RS08915	COG0606	chelatase, subunit chli
I6I95_RS08920	COG2814	Major facilitator Superfamily
I6I95_RS08935	COG3978	acetolactate synthase activity
I6I95_RS08940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I95_RS08945	COG0129	dihydroxy-acid dehydratase activity
I6I95_RS08950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I95_RS08960	COG0583	DNA-binding transcription factor activity
I6I95_RS08965	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I95_RS08970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I95_RS08975	COG1942	4-Oxalocrotonate Tautomerase
I6I95_RS08980	COG2200	EAL domain
I6I95_RS08985	COG2982	Protein involved in outer membrane biogenesis
I6I95_RS08990	COG2134	cdp-diacylglycerol pyrophosphatase
I6I95_RS08995	COG0477	Major facilitator Superfamily
I6I95_RS09000	COG1295	ribonuclease BN
I6I95_RS09010	COG1024	Enoyl-CoA hydratase
I6I95_RS09015	COG5001	Diguanylate cyclase
I6I95_RS09020	COG3678	ATP-independent chaperone mediated protein folding
I6I95_RS09025	COG5564	TIM-barrel signal transduction protein
I6I95_RS09030	COG5441	Belongs to the UPF0261 family
I6I95_RS09035	COG1309	transcriptional regulator
I6I95_RS09055	COG0784	Response regulator, receiver
I6I95_RS09055	COG2205	protein histidine kinase activity
I6I95_RS09075	COG2318	DinB family
I6I95_RS09080	COG2831	hemolysin activation secretion protein
I6I95_RS09085	COG3210	domain, Protein
I6I95_RS09120	COG3188	usher protein
I6I95_RS09125	COG3121	Chaperone
I6I95_RS09185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I95_RS09190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I95_RS09205	COG0339	signal peptide processing
I6I95_RS09210	COG0742	ribosomal rna small subunit methyltransferase
I6I95_RS09215	COG0517	IMP dehydrogenase activity
I6I95_RS09215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I95_RS09225	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS09230	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS09235	COG1129	ABC transporter
I6I95_RS09250	COG0589	response to stress
I6I95_RS09260	COG0306	phosphate transporter
I6I95_RS09265	COG2081	HI0933 family
I6I95_RS09295	COG2995	paraquat-inducible protein a
I6I95_RS09300	COG3008	intermembrane lipid transfer
I6I95_RS09300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I95_RS09330	COG2197	response regulator
I6I95_RS09360	COG3188	usher protein
I6I95_RS09390	COG4619	ABC transporter
I6I95_RS09395	COG0390	transport system, permease component
I6I95_RS09405	COG2814	Major facilitator Superfamily
I6I95_RS09405	COG0477	Major facilitator Superfamily
I6I95_RS09415	COG3718	enzyme involved in inositol metabolism
I6I95_RS09425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I95_RS09435	COG3962	Belongs to the TPP enzyme family
I6I95_RS09440	COG0673	inositol 2-dehydrogenase activity
I6I95_RS09445	COG1082	Xylose isomerase domain protein TIM barrel
I6I95_RS09450	COG1082	Xylose isomerase domain protein TIM barrel
I6I95_RS09455	COG3191	aminopeptidase activity
I6I95_RS09460	COG1247	-acetyltransferase
I6I95_RS09465	COG1741	Belongs to the pirin family
I6I95_RS09470	COG1609	Transcriptional regulator
I6I95_RS09475	COG2610	gluconate transmembrane transporter activity
I6I95_RS09480	COG3265	gluconokinase activity
I6I95_RS09485	COG2095	MarC family integral membrane protein
I6I95_RS09490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I95_RS09495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I95_RS09500	COG1523	belongs to the glycosyl hydrolase 13 family
I6I95_RS09505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I95_RS09510	COG0297	glycogen (starch) synthase activity
I6I95_RS09515	COG0058	SHG alpha-glucan phosphorylase activity
I6I95_RS09520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I95_RS09525	COG1349	DNA-binding transcription factor activity
I6I95_RS09530	COG0705	Rhomboid family
I6I95_RS09535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I95_RS09545	COG2731	YhcH YjgK YiaL family protein
I6I95_RS09550	COG2271	Major facilitator Superfamily
I6I95_RS09555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I95_RS09560	COG2909	trisaccharide binding
I6I95_RS09565	COG0058	SHG alpha-glucan phosphorylase activity
I6I95_RS09570	COG1640	4-alpha-glucanotransferase
I6I95_RS09575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I95_RS09575	COG0316	Belongs to the HesB IscA family
I6I95_RS09580	COG1040	competence protein
I6I95_RS09585	COG2267	carboxylic ester hydrolase activity
I6I95_RS09605	COG1918	ferrous iron import across plasma membrane
I6I95_RS09610	COG2183	response to ionizing radiation
I6I95_RS09615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I95_RS09645	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I95_RS09650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I95_RS09655	COG1011	Hydrolase
I6I95_RS09665	COG0494	nUDIX hydrolase
I6I95_RS09670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I95_RS09695	COG4796	Type ii and iii secretion system protein
I6I95_RS09700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I95_RS09705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I95_RS09725	COG0546	phosphoglycolate phosphatase activity
I6I95_RS09730	COG0180	Tryptophanyl-tRNA synthetase
I6I95_RS09735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I95_RS09735	COG1648	precorrin-2 dehydrogenase activity
I6I95_RS09750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I95_RS09755	COG0402	S-adenosylhomocysteine deaminase activity
I6I95_RS09760	COG0738	Major facilitator superfamily
I6I95_RS09765	COG1609	Transcriptional regulator
I6I95_RS09770	COG1486	melibiose metabolic process
I6I95_RS09775	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I95_RS09780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I95_RS09785	COG3275	phosphorelay sensor kinase activity
I6I95_RS09805	COG0433	COG0433 Predicted ATPase
I6I95_RS09820	COG1289	transmembrane transporter activity
I6I95_RS09825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I95_RS09830	COG1765	OsmC-like protein
I6I95_RS09835	COG3954	Phosphoribulokinase
I6I95_RS09840	COG3089	Belongs to the UPF0270 family
I6I95_RS09845	COG0429	hydrolase of the alpha beta-hydrolase fold
I6I95_RS09860	COG4521	taurine ABC transporter
I6I95_RS09870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I95_RS09875	COG2175	clavaminate synthase activity
I6I95_RS09880	COG0488	(ABC) transporter
I6I95_RS09885	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I95_RS09895	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I95_RS09900	COG1047	Peptidyl-prolyl cis-trans
I6I95_RS09905	COG2900	Belongs to the SlyX family
I6I95_RS09910	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I95_RS09915	COG2964	Protein conserved in bacteria
I6I95_RS09920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I95_RS09925	COG2923	Belongs to the DsrF TusC family
I6I95_RS09930	COG2168	tRNA wobble position uridine thiolation
I6I95_RS09935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I95_RS09940	COG0049	tRNA binding
I6I95_RS09945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I95_RS09950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I95_RS09965	COG0051	transcription antitermination factor activity, RNA binding
I6I95_RS09970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I95_RS09975	COG0088	Forms part of the polypeptide exit tunnel
I6I95_RS09980	COG0089	rRNA binding
I6I95_RS09990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I95_RS10000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I95_RS10005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I95_RS10010	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I95_RS10015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I95_RS10020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I95_RS10025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I95_RS10030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I95_RS10035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I95_RS10040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I95_RS10045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I95_RS10050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I95_RS10055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I95_RS10060	COG1841	ribosomal large subunit assembly
I6I95_RS10065	COG0200	Binds to the 23S rRNA
I6I95_RS10070	COG0201	protein transport
I6I95_RS10075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I95_RS10080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I95_RS10085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I95_RS10090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I95_RS10095	COG0202	RNA polymerase activity
I6I95_RS10100	COG0203	ribosomal protein L17
I6I95_RS10110	COG0789	Transcriptional regulator
I6I95_RS10115	COG3036	rescue of stalled ribosome
I6I95_RS10120	COG1970	mechanosensitive ion channel activity
I6I95_RS10125	COG0569	domain protein
I6I95_RS10130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I95_RS10130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I95_RS10135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I95_RS10140	COG0242	peptide deformylase activity
I6I95_RS10145	COG0758	DNA mediated transformation
I6I95_RS10150	COG2922	Belongs to the Smg family
I6I95_RS10155	COG0551	DNA topoisomerase type I activity
I6I95_RS10160	COG0009	L-threonylcarbamoyladenylate synthase
I6I95_RS10165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I95_RS10170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I95_RS10205	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6I95_RS10210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I95_RS10215	COG2224	Isocitrate lyase
I6I95_RS10220	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I95_RS10225	COG0800	Aldolase
I6I95_RS10230	COG0129	dihydroxy-acid dehydratase activity
I6I95_RS10235	COG2610	gluconate transmembrane transporter activity
I6I95_RS10240	COG3265	gluconokinase activity
I6I95_RS10245	COG1414	Transcriptional regulator
I6I95_RS10255	COG2188	Transcriptional regulator
I6I95_RS10270	COG4149	molybdate abc transporter
I6I95_RS10280	COG3842	ATPase activity
I6I95_RS10285	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I95_RS10305	COG0527	aspartate kinase activity
I6I95_RS10315	COG0166	Belongs to the GPI family
I6I95_RS10325	COG3223	Belongs to the PsiE family
I6I95_RS10330	COG3833	ABC-type maltose transport systems, permease component
I6I95_RS10335	COG1175	transmembrane transport
I6I95_RS10340	COG2182	Extracellular solute-binding protein
I6I95_RS10345	COG0366	Alpha amylase catalytic
I6I95_RS10355	COG4580	involved in the transport of maltose and maltodextrins
I6I95_RS10370	COG1609	Transcriptional regulator
I6I95_RS10375	COG0477	Major facilitator Superfamily
I6I95_RS10380	COG3161	chorismate lyase activity
I6I95_RS10385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I95_RS10390	COG2937	Belongs to the GPAT DAPAT family
I6I95_RS10395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I95_RS10400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I95_RS10405	COG0534	Mate efflux family protein
I6I95_RS10410	COG3237	CsbD-like
I6I95_RS10415	COG0735	belongs to the Fur family
I6I95_RS10425	COG1595	DNA-templated transcription, initiation
I6I95_RS10435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I95_RS10445	COG0604	alcohol dehydrogenase
I6I95_RS10465	COG1113	amino acid transport
I6I95_RS10470	COG1522	sequence-specific DNA binding
I6I95_RS10480	COG1448	Aminotransferase
I6I95_RS10490	COG2315	Protein conserved in bacteria
I6I95_RS10495	COG0110	maltose O-acetyltransferase activity
I6I95_RS10500	COG1064	alcohol dehydrogenase
I6I95_RS10505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I95_RS10510	COG0629	single-stranded DNA binding
I6I95_RS10515	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS10520	COG0583	DNA-binding transcription factor activity
I6I95_RS10530	COG0625	glutathione transferase activity
I6I95_RS10540	COG2252	PERMEase
I6I95_RS10545	COG0025	NhaP-type Na H and K H
I6I95_RS10550	COG0583	DNA-binding transcription factor activity
I6I95_RS10555	COG1380	Effector of murein hydrolase LrgA
I6I95_RS10570	COG1560	Kdo2-lipid A biosynthetic process
I6I95_RS10660	COG2264	protein methyltransferase activity
I6I95_RS10665	COG4145	pantothenate transmembrane transporter activity
I6I95_RS10670	COG3924	membrane
I6I95_RS10675	COG0439	Biotin carboxylase
I6I95_RS10680	COG0511	ligase activity, forming carbon-carbon bonds
I6I95_RS10685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I95_RS10690	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I95_RS10695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I95_RS10700	COG0604	alcohol dehydrogenase
I6I95_RS10705	COG2199	diguanylate cyclase activity
I6I95_RS10705	COG2200	EAL domain
I6I95_RS10710	COG1077	Cell shape determining protein MreB Mrl
I6I95_RS10715	COG1792	Involved in formation and maintenance of cell shape
I6I95_RS10720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I95_RS10725	COG0424	maF-like protein
I6I95_RS10730	COG1530	ribonuclease E activity
I6I95_RS10735	COG3164	Protein of unknown function
I6I95_RS10740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I95_RS10745	COG0312	modulator of DNA gyrase
I6I95_RS10785	COG3210	domain, Protein
I6I95_RS10810	COG0583	DNA-binding transcription factor activity
I6I95_RS10820	COG1566	PFAM secretion protein HlyD family protein
I6I95_RS10825	COG1289	transmembrane transporter activity
I6I95_RS10835	COG2732	(Barnase) inhibitor
I6I95_RS10840	COG3028	Belongs to the UPF0307 family
I6I95_RS10845	COG0312	modulator of DNA gyrase
I6I95_RS10850	COG3783	Cytochrome b(562)
I6I95_RS10855	COG2207	Transcriptional regulator
I6I95_RS10865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I95_RS10875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I95_RS10905	COG3964	amidohydrolase
I6I95_RS10920	COG2706	6-phosphogluconolactonase activity
I6I95_RS10925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I95_RS10925	COG3711	transcriptional antiterminator
I6I95_RS10930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I95_RS10935	COG1660	Displays ATPase and GTPase activities
I6I95_RS10950	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I95_RS10955	COG1137	ATPase activity
I6I95_RS10960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I95_RS10965	COG3117	lipopolysaccharide transmembrane transporter activity
I6I95_RS10970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I95_RS10975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I95_RS10975	COG0517	IMP dehydrogenase activity
I6I95_RS10980	COG0530	calcium, potassium:sodium antiporter activity
I6I95_RS10985	COG1127	ABC transporter
I6I95_RS10990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I95_RS10995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I95_RS11000	COG2854	intermembrane phospholipid transfer
I6I95_RS11005	COG3113	response to antibiotic
I6I95_RS11010	COG5007	Belongs to the BolA IbaG family
I6I95_RS11015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I95_RS11020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I95_RS11025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I95_RS11030	COG3105	Protein conserved in bacteria
I6I95_RS11035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I95_RS11040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I95_RS11045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I95_RS11050	COG0625	glutathione transferase activity
I6I95_RS11055	COG2969	positive regulation of protein catabolic process
I6I95_RS11060	COG0493	'glutamate synthase
I6I95_RS11065	COG0070	glutamate synthase
I6I95_RS11065	COG0069	glutamate synthase activity
I6I95_RS11065	COG0067	glutamate synthase
I6I95_RS11070	COG1242	4 iron, 4 sulfur cluster binding
I6I95_RS11075	COG0784	Response regulator, receiver
I6I95_RS11075	COG5002	protein histidine kinase activity
I6I95_RS11075	COG2198	Histidine kinase
I6I95_RS11080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6I95_RS11090	COG2823	Periplasmic or secreted lipoprotein
I6I95_RS11095	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I95_RS11100	COG0792	nuclease activity
I6I95_RS11105	COG3107	peptidoglycan biosynthetic process
I6I95_RS11110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I95_RS11120	COG1741	Belongs to the pirin family
I6I95_RS11125	COG0583	DNA-binding transcription factor activity
I6I95_RS11130	COG0435	Glutathione S-transferase
I6I95_RS11135	COG2259	Doxx family
I6I95_RS11145	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6I95_RS11150	COG4575	ribosome binding
I6I95_RS11160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I95_RS11165	COG0586	Pfam SNARE associated Golgi protein
I6I95_RS11185	COG1904	glucuronate isomerase
I6I95_RS11190	COG2721	sulfolactate sulfo-lyase activity
I6I95_RS11200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I95_RS11205	COG0861	Integral membrane protein TerC family
I6I95_RS11215	COG0673	inositol 2-dehydrogenase activity
I6I95_RS11220	COG1451	nucleotide metabolic process
I6I95_RS11225	COG2813	Specifically methylates the guanine in position
I6I95_RS11230	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I95_RS11230	COG1902	pentaerythritol trinitrate reductase activity
I6I95_RS11245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I95_RS11250	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS11260	COG0625	glutathione transferase activity
I6I95_RS11280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I95_RS11300	COG4220	transposase activity
I6I95_RS11315	COG3663	DNA glycosylase
I6I95_RS11325	COG0358	DNA primase activity
I6I95_RS11330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I95_RS11335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I95_RS11340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I95_RS11345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I95_RS11350	COG1968	undecaprenyl-diphosphatase activity
I6I95_RS11355	COG0617	tRNA 3'-terminal CCA addition
I6I95_RS11360	COG4991	sh3 domain protein
I6I95_RS11365	COG3025	triphosphatase activity
I6I95_RS11370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I95_RS11375	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I95_RS11375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I95_RS11380	COG0531	amino acid
I6I95_RS11385	COG2960	long-chain fatty acid transporting porin activity
I6I95_RS11390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I95_RS11405	COG3384	dioxygenase
I6I95_RS11410	COG0754	glutathionylspermidine amidase activity
I6I95_RS11415	COG5463	Belongs to the UPF0441 family
I6I95_RS11425	COG2376	Dihydroxyacetone kinase
I6I95_RS11430	COG1461	Dihydroxyacetone kinase
I6I95_RS11445	COG1538	Outer membrane efflux protein
I6I95_RS11450	COG0494	nUDIX hydrolase
I6I95_RS11455	COG3151	Protein conserved in bacteria
I6I95_RS11460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I95_RS11465	COG3150	esterase
I6I95_RS11475	COG0583	DNA-binding transcription factor activity
I6I95_RS11480	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I95_RS11485	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I95_RS11490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I95_RS11500	COG2132	Multicopper oxidase
I6I95_RS11515	COG0741	lytic transglycosylase activity
I6I95_RS11525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I95_RS11530	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I95_RS11535	COG2723	6-phospho-beta-galactosidase activity
I6I95_RS11540	COG0656	L-ascorbic acid biosynthetic process
I6I95_RS11545	COG1979	alcohol dehydrogenase
I6I95_RS11550	COG2207	Transcriptional regulator
I6I95_RS11560	COG0583	DNA-binding transcription factor activity
I6I95_RS11565	COG0586	Pfam SNARE associated Golgi protein
I6I95_RS11570	COG0675	Transposase, IS605 OrfB family
I6I95_RS11590	COG0848	biopolymer transport protein
I6I95_RS11595	COG3609	addiction module antidote protein, CC2985 family
I6I95_RS11605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I95_RS11635	COG2831	hemolysin activation secretion protein
I6I95_RS11640	COG2994	toxin metabolic process
I6I95_RS11645	COG3210	domain, Protein
I6I95_RS11690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I95_RS11690	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I95_RS11730	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I95_RS11735	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6I95_RS11740	COG3383	formate dehydrogenase (NAD+) activity
I6I95_RS11745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I95_RS11750	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6I95_RS11760	COG3260	NADH ubiquinone oxidoreductase 20
I6I95_RS11765	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I95_RS11770	COG3261	NADH dehydrogenase
I6I95_RS11770	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6I95_RS11775	COG0650	Formate hydrogenlyase subunit 4
I6I95_RS11780	COG0651	ATP synthesis coupled electron transport
I6I95_RS11785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I95_RS11795	COG0375	protein maturation
I6I95_RS11800	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I95_RS11805	COG0298	carbon dioxide binding
I6I95_RS11810	COG0409	Hydrogenase expression formation protein
I6I95_RS11815	COG0309	Hydrogenase expression formation protein (HypE)
I6I95_RS11835	COG0076	glutamate decarboxylase activity
I6I95_RS11850	COG1566	PFAM secretion protein HlyD family protein
I6I95_RS11855	COG1136	(ABC) transporter
I6I95_RS11875	COG3321	synthase
I6I95_RS11875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I95_RS11875	COG0300	oxidoreductase activity
I6I95_RS11875	COG4221	oxidoreductase activity
I6I95_RS11880	COG2070	2-Nitropropane dioxygenase
I6I95_RS11880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I95_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS11890	COG3320	Male sterility
I6I95_RS11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I95_RS11900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I95_RS11925	COG1131	(ABC) transporter
I6I95_RS11935	COG0823	Involved in the tonB-independent uptake of proteins
I6I95_RS11935	COG1506	peptidase
I6I95_RS11970	COG0475	glutathione-regulated potassium exporter activity
I6I95_RS12005	COG0745	RESPONSE REGULATOR receiver
I6I95_RS12020	COG3547	Transposase (IS116 IS110 IS902 family)
I6I95_RS12090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS12090	COG2205	protein histidine kinase activity
I6I95_RS12095	COG2197	response regulator
I6I95_RS12130	COG2990	Protein conserved in bacteria
I6I95_RS12145	COG0745	RESPONSE REGULATOR receiver
I6I95_RS12150	COG5002	protein histidine kinase activity
I6I95_RS12200	COG2990	Protein conserved in bacteria
I6I95_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS12210	COG0583	DNA-binding transcription factor activity
I6I95_RS12220	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS12245	COG1982	Orn Lys Arg decarboxylase major
I6I95_RS12250	COG0741	lytic transglycosylase activity
I6I95_RS12255	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I95_RS12260	COG1194	a g-specific adenine glycosylase
I6I95_RS12265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I95_RS12270	COG3171	Protein conserved in bacteria
I6I95_RS12275	COG2066	Belongs to the glutaminase family
I6I95_RS12295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I95_RS12300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I95_RS12305	COG1872	DUF167
I6I95_RS12310	COG0762	integral membrane protein
I6I95_RS12315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I95_RS12320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I95_RS12325	COG2805	Type II/IV secretion system protein
I6I95_RS12330	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I95_RS12335	COG1678	Uncharacterized ACR, COG1678
I6I95_RS12340	COG0189	ligase activity
I6I95_RS12345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I95_RS12350	COG2356	endonuclease I
I6I95_RS12355	COG3091	SprT-like family
I6I95_RS12360	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I95_RS12360	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I95_RS12365	COG3708	Transcriptional regulator
I6I95_RS12365	COG2207	Transcriptional regulator
I6I95_RS12370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I95_RS12380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I95_RS12390	COG2010	Cytochrome c
I6I95_RS12390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I95_RS12395	COG3940	Belongs to the glycosyl hydrolase 43 family
I6I95_RS12400	COG2211	Major facilitator Superfamily
I6I95_RS12405	COG1113	amino acid transport
I6I95_RS12410	COG2186	Transcriptional regulator
I6I95_RS12415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I95_RS12420	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I95_RS12425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I95_RS12435	COG3112	Uncharacterised protein family (UPF0231)
I6I95_RS12440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I95_RS12445	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I95_RS12455	COG2132	Multicopper oxidase
I6I95_RS12465	COG0288	reversible hydration of carbon dioxide
I6I95_RS12470	COG1131	(ABC) transporter
I6I95_RS12475	COG0842	Transport permease protein
I6I95_RS12480	COG0726	polysaccharide deacetylase
I6I95_RS12485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I95_RS12490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I95_RS12495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I95_RS12500	COG0745	RESPONSE REGULATOR receiver
I6I95_RS12505	COG0642	Histidine kinase
I6I95_RS12510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I95_RS12520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I95_RS12530	COG1489	DNA binding
I6I95_RS12535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I95_RS12540	COG1643	Atp-dependent helicase
I6I95_RS12545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I95_RS12550	COG4774	siderophore transport
I6I95_RS12555	COG1120	ATPase activity
I6I95_RS12560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I95_RS12565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I95_RS12575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I95_RS12585	COG1166	arginine decarboxylase activity
I6I95_RS12595	COG0010	Belongs to the arginase family
I6I95_RS12600	COG1187	pseudouridine synthase activity
I6I95_RS12605	COG2146	nitrite reductase [NAD(P)H] activity
I6I95_RS12625	COG1414	Transcriptional regulator
I6I95_RS12640	COG2271	Major facilitator Superfamily
I6I95_RS12655	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS12660	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I95_RS12675	COG0501	Belongs to the peptidase M48B family
I6I95_RS12680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I95_RS12685	COG0583	DNA-binding transcription factor activity
I6I95_RS12690	COG0471	metal ion transport
I6I95_RS12695	COG0406	alpha-ribazole phosphatase activity
I6I95_RS12705	COG1175	transmembrane transport
I6I95_RS12710	COG3842	ATPase activity
I6I95_RS12715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I95_RS12720	COG0126	phosphoglycerate kinase activity
I6I95_RS12725	COG0191	fructose-bisphosphate aldolase activity
I6I95_RS12740	COG3122	Protein conserved in bacteria
I6I95_RS12750	COG0235	Class ii aldolase
I6I95_RS12755	COG3623	hexulose-6-phosphate isomerase
I6I95_RS12760	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6I95_RS12765	COG1070	Carbohydrate kinase
I6I95_RS12775	COG2731	YhcH YjgK YiaL family protein
I6I95_RS12795	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS12800	COG1129	ABC transporter
I6I95_RS12805	COG1414	Transcriptional regulator
I6I95_RS12810	COG1279	arginine transmembrane transporter activity
I6I95_RS12820	COG0583	DNA-binding transcription factor activity
I6I95_RS12825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I95_RS12830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I95_RS12835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I95_RS12845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6I95_RS12850	COG3079	Belongs to the UPF0149 family
I6I95_RS12855	COG0006	proline dipeptidase activity
I6I95_RS12860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I95_RS12865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I95_RS12880	COG1509	lysine 2,3-aminomutase activity
I6I95_RS12885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I95_RS12890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I95_RS12895	COG0509	glycine decarboxylation via glycine cleavage system
I6I95_RS12900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I95_RS12900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I95_RS12920	COG3713	MltA-interacting MipA family protein
I6I95_RS12925	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS12960	COG1272	protein, Hemolysin III
I6I95_RS12970	COG0354	folic acid binding
I6I95_RS12975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I95_RS12985	COG0745	RESPONSE REGULATOR receiver
I6I95_RS12990	COG2205	protein histidine kinase activity
I6I95_RS12995	COG4452	Inner membrane protein CreD
I6I95_RS13000	COG0716	FMN binding
I6I95_RS13005	COG4974	Belongs to the 'phage' integrase family
I6I95_RS13010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I95_RS13015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I95_RS13025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I95_RS13035	COG1278	Cold shock
I6I95_RS13045	COG0484	heat shock protein binding
I6I95_RS13050	COG3247	response to pH
I6I95_RS13055	COG4942	peptidase
I6I95_RS13075	COG5265	(ABC) transporter
I6I95_RS13080	COG1942	4-Oxalocrotonate Tautomerase
I6I95_RS13090	COG1309	transcriptional regulator
I6I95_RS13095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I95_RS13100	COG1304	FMN binding
I6I95_RS13105	COG0583	DNA-binding transcription factor activity
I6I95_RS13130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS13140	COG1538	Outer membrane efflux protein
I6I95_RS13145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I95_RS13150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I95_RS13155	COG0582	viral genome integration into host DNA
I6I95_RS13160	COG3539	Fimbrial protein
I6I95_RS13165	COG3121	Chaperone
I6I95_RS13180	COG3539	Fimbrial protein
I6I95_RS13185	COG2197	response regulator
I6I95_RS13190	COG2197	response regulator
I6I95_RS13195	COG0582	viral genome integration into host DNA
I6I95_RS13200	COG4615	Cyclic peptide transporter
I6I95_RS13215	COG2807	transmembrane transport
I6I95_RS13220	COG4178	(ABC) transporter
I6I95_RS13240	COG0583	DNA-binding transcription factor activity
I6I95_RS13245	COG2814	Major facilitator Superfamily
I6I95_RS13250	COG0583	DNA-binding transcription factor activity
I6I95_RS13260	COG1609	Transcriptional regulator
I6I95_RS13270	COG1609	Transcriptional regulator
I6I95_RS13280	COG0204	Acyl-transferase
I6I95_RS13280	COG0318	PFAM AMP-dependent synthetase and ligase
I6I95_RS13285	COG0477	Major facilitator Superfamily
I6I95_RS13290	COG0667	Aldo Keto reductase
I6I95_RS13300	COG0861	Integral membrane protein TerC family
I6I95_RS13305	COG3066	DNA modification
I6I95_RS13310	COG0494	nUDIX hydrolase
I6I95_RS13320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I95_RS13325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I95_RS13350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I95_RS13355	COG1025	Belongs to the peptidase M16 family
I6I95_RS13360	COG1074	ATP-dependent DNA helicase activity
I6I95_RS13365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I95_RS13370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I95_RS13370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I95_RS13375	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I95_RS13395	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6I95_RS13400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I95_RS13405	COG2166	iron-sulfur cluster assembly
I6I95_RS13410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I95_RS13420	COG0583	DNA-binding transcription factor activity
I6I95_RS13425	COG2363	Small membrane protein
I6I95_RS13430	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6I95_RS13435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I95_RS13440	COG1611	Belongs to the LOG family
I6I95_RS13460	COG2814	Major facilitator Superfamily
I6I95_RS13465	COG3098	single-species biofilm formation
I6I95_RS13470	COG0564	pseudouridine synthase activity
I6I95_RS13490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I95_RS13500	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I95_RS13505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I95_RS13510	COG0528	UMP kinase activity
I6I95_RS13515	COG0233	cytoplasmic translational termination
I6I95_RS13520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I95_RS13525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I95_RS13530	COG0575	Belongs to the CDS family
I6I95_RS13535	COG0750	zinc metalloprotease
I6I95_RS13540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I95_RS13545	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6I95_RS13550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I95_RS13555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I95_RS13560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I95_RS13565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I95_RS13570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I95_RS13580	COG0825	malonyl-CoA metabolic process
I6I95_RS13585	COG1982	Orn Lys Arg decarboxylase major
I6I95_RS13590	COG0346	lactoylglutathione lyase activity
I6I95_RS13595	COG0037	tRNA processing
I6I95_RS13605	COG4568	rho-dependent transcription termination
I6I95_RS13620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I95_RS13625	COG3015	lipoprotein NlpE involved in copper resistance
I6I95_RS13630	COG0442	prolyl-tRNA aminoacylation
I6I95_RS13635	COG1720	tRNA m6t6A37 methyltransferase activity
I6I95_RS13650	COG2011	ABC-type metal ion transport system permease component
I6I95_RS13660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I95_RS13690	COG0477	Major facilitator Superfamily
I6I95_RS13695	COG5544	Lipoprotein
I6I95_RS13700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I95_RS13705	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I95_RS13705	COG1042	CoA-binding domain protein
I6I95_RS13705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I95_RS13710	COG3148	PFAM DTW domain containing protein
I6I95_RS13715	COG3118	belongs to the thioredoxin family
I6I95_RS13720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I95_RS13725	COG2814	Major facilitator Superfamily
I6I95_RS13730	COG1566	PFAM secretion protein HlyD family protein
I6I95_RS13740	COG1846	Transcriptional regulator
I6I95_RS13750	COG2814	Major facilitator Superfamily
I6I95_RS13755	COG0583	DNA-binding transcription factor activity
I6I95_RS13760	COG2113	Glycine betaine
I6I95_RS13765	COG4176	ABC-type proline glycine betaine transport system permease component
I6I95_RS13785	COG3493	citrate carrier protein
I6I95_RS13795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I95_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS13825	COG1780	Probably involved in ribonucleotide reductase function
I6I95_RS13830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I95_RS13835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I95_RS13845	COG4575	ribosome binding
I6I95_RS13850	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I95_RS13870	COG0583	DNA-binding transcription factor activity
I6I95_RS13885	COG0477	Major facilitator Superfamily
I6I95_RS13905	COG2259	Doxx family
I6I95_RS13910	COG2388	GCN5-related N-acetyl-transferase
I6I95_RS13920	COG2226	methyltransferase
I6I95_RS13935	COG3713	MltA-interacting MipA family protein
I6I95_RS13940	COG0667	Aldo Keto reductase
I6I95_RS13945	COG0583	DNA-binding transcription factor activity
I6I95_RS14025	COG2003	Belongs to the UPF0758 family
I6I95_RS14055	COG2378	regulation of single-species biofilm formation
I6I95_RS14065	COG3596	GTP binding
I6I95_RS14075	COG1061	Type III restriction enzyme res subunit
I6I95_RS14090	COG4983	Phage plasmid primase, P4 family domain protein
I6I95_RS14095	COG3311	Transcriptional regulator
I6I95_RS14105	COG0582	viral genome integration into host DNA
I6I95_RS14115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I95_RS14120	COG2867	negative regulation of translational initiation
I6I95_RS14125	COG2914	Belongs to the UPF0125 (RnfH) family
I6I95_RS14130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I95_RS14135	COG0497	DNA recombination
I6I95_RS14140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I95_RS14145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I95_RS14150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I95_RS14155	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I6I95_RS14170	COG0513	Belongs to the DEAD box helicase family
I6I95_RS14175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I95_RS14180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I95_RS14200	COG3086	response to oxidative stress
I6I95_RS14210	COG0481	GTPase activity
I6I95_RS14215	COG0681	Belongs to the peptidase S26 family
I6I95_RS14220	COG0571	ribonuclease III activity
I6I95_RS14225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I95_RS14230	COG1381	Involved in DNA repair and RecF pathway recombination
I6I95_RS14235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I95_RS14240	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I95_RS14245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I95_RS14250	COG1737	Transcriptional regulator
I6I95_RS14255	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I95_RS14260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS14260	COG1263	PTS System
I6I95_RS14265	COG0560	Phosphoserine phosphatase
I6I95_RS14280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I95_RS14295	COG2205	protein histidine kinase activity
I6I95_RS14300	COG3170	Tfp pilus assembly protein FimV
I6I95_RS14305	COG2204	response regulator
I6I95_RS14310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I95_RS14310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I95_RS14315	COG0347	Belongs to the P(II) protein family
I6I95_RS14330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I95_RS14335	COG3842	ATPase activity
I6I95_RS14340	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I95_RS14345	COG1177	transmembrane transport
I6I95_RS14350	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS14355	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I95_RS14365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I95_RS14365	COG1017	nitric oxide dioxygenase activity
I6I95_RS14370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I95_RS14375	COG2814	Major facilitator Superfamily
I6I95_RS14380	COG3711	transcriptional antiterminator
I6I95_RS14385	COG3683	transport system, periplasmic component
I6I95_RS14390	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I95_RS14405	COG1959	2 iron, 2 sulfur cluster binding
I6I95_RS14410	COG1104	cysteine desulfurase activity
I6I95_RS14415	COG0822	iron-sulfur transferase activity
I6I95_RS14420	COG0316	Belongs to the HesB IscA family
I6I95_RS14425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I95_RS14430	COG0443	Heat shock 70 kDa protein
I6I95_RS14435	COG0633	Ferredoxin
I6I95_RS14440	COG2975	iron-sulfur cluster assembly
I6I95_RS14445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I95_RS14455	COG2373	Large extracellular alpha-helical protein
I6I95_RS14460	COG4953	penicillin-binding protein 1C
I6I95_RS14465	COG0105	UTP biosynthetic process
I6I95_RS14470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I95_RS14480	COG1426	Protein conserved in bacteria
I6I95_RS14485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I95_RS14490	COG0124	histidyl-tRNA synthetase
I6I95_RS14495	COG2976	Protein conserved in bacteria
I6I95_RS14500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I95_RS14505	COG1160	GTP binding
I6I95_RS14515	COG1645	bacterial-type flagellum-dependent swarming motility
I6I95_RS14530	COG1609	Transcriptional regulator
I6I95_RS14535	COG2271	Major facilitator Superfamily
I6I95_RS14545	COG1570	exodeoxyribonuclease VII activity
I6I95_RS14550	COG0517	IMP dehydrogenase activity
I6I95_RS14550	COG0516	GMP reductase activity
I6I95_RS14555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I95_RS14555	COG0519	Catalyzes the synthesis of GMP from XMP
I6I95_RS14600	COG1733	regulation of RNA biosynthetic process
I6I95_RS14610	COG2198	Histidine kinase
I6I95_RS14610	COG2205	protein histidine kinase activity
I6I95_RS14610	COG0784	Response regulator, receiver
I6I95_RS14615	COG2197	response regulator
I6I95_RS14640	COG2814	Major facilitator Superfamily
I6I95_RS14655	COG0456	acetyltransferase
I6I95_RS14660	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I95_RS14665	COG0351	phosphomethylpyrimidine kinase
I6I95_RS14680	COG1349	DNA-binding transcription factor activity
I6I95_RS14685	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I95_RS14690	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS14705	COG3730	PTS system glucitol sorbitol-specific
I6I95_RS14710	COG1830	Aldolase
I6I95_RS14715	COG1802	Transcriptional regulator
I6I95_RS14720	COG0246	Mannitol dehydrogenase
I6I95_RS14725	COG2271	Major facilitator Superfamily
I6I95_RS14730	COG1063	alcohol dehydrogenase
I6I95_RS14735	COG4948	Mandelate Racemase Muconate Lactonizing
I6I95_RS14740	COG1597	lipid kinase activity
I6I95_RS14745	COG0826	peptidase U32
I6I95_RS14750	COG3422	double-strand break repair
I6I95_RS14760	COG0745	RESPONSE REGULATOR receiver
I6I95_RS14765	COG2205	protein histidine kinase activity
I6I95_RS14770	COG2814	Major facilitator Superfamily
I6I95_RS14775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I95_RS14780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I95_RS14785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS14790	COG0667	Aldo Keto reductase
I6I95_RS14800	COG0529	Catalyzes the synthesis of activated sulfate
I6I95_RS14800	COG2046	Belongs to the sulfate adenylyltransferase family
I6I95_RS14810	COG0443	Heat shock 70 kDa protein
I6I95_RS14815	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6I95_RS14825	COG5002	protein histidine kinase activity
I6I95_RS14825	COG5001	Diguanylate cyclase
I6I95_RS14825	COG3447	MASE1 domain protein
I6I95_RS14830	COG2239	Acts as a magnesium transporter
I6I95_RS14845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I95_RS14850	COG0573	inorganic phosphate transmembrane transporter activity
I6I95_RS14855	COG0573	inorganic phosphate transmembrane transporter activity
I6I95_RS14870	COG3210	domain, Protein
I6I95_RS14890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I95_RS14895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I95_RS14900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I95_RS14905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I95_RS14910	COG2233	PERMEase
I6I95_RS14915	COG2261	transglycosylase associated protein
I6I95_RS14925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I95_RS14935	COG1393	Belongs to the ArsC family
I6I95_RS14940	COG4783	chaperone-mediated protein folding
I6I95_RS14975	COG0243	molybdopterin cofactor binding
I6I95_RS14980	COG0542	response to heat
I6I95_RS14985	COG2837	iron assimilation
I6I95_RS14990	COG1271	oxidase subunit
I6I95_RS14995	COG1294	oxidase, subunit
I6I95_RS15010	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6I95_RS15015	COG0314	molybdopterin synthase activity
I6I95_RS15020	COG3781	membrane
I6I95_RS15025	COG0628	permease
I6I95_RS15030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I95_RS15035	COG2716	regulation of RNA biosynthetic process
I6I95_RS15040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I95_RS15045	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I95_RS15050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I95_RS15055	COG2321	neutral zinc metallopeptidase
I6I95_RS15065	COG0400	carboxylic ester hydrolase activity
I6I95_RS15090	COG1876	peptidase activity
I6I95_RS15095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I95_RS15100	COG1393	Belongs to the ArsC family
I6I95_RS15120	COG0456	acetyltransferase
I6I95_RS15140	COG4771	TonB-dependent receptor
I6I95_RS15150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I95_RS15160	COG2197	response regulator
I6I95_RS15165	COG3850	Histidine kinase
I6I95_RS15170	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I95_RS15170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I95_RS15175	COG3062	negative regulation of establishment of protein localization
I6I95_RS15180	COG0243	molybdopterin cofactor binding
I6I95_RS15185	COG3043	anaerobic respiration
I6I95_RS15190	COG3005	denitrification pathway
I6I95_RS15195	COG0494	nUDIX hydrolase
I6I95_RS15200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I95_RS15205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I95_RS15210	COG3397	chitin binding
I6I95_RS15215	COG0583	DNA-binding transcription factor activity
I6I95_RS15250	COG2040	homocysteine
I6I95_RS15255	COG0833	amino acid
I6I95_RS15270	COG0408	coproporphyrinogen oxidase activity
I6I95_RS15280	COG0456	acetyltransferase
I6I95_RS15285	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I95_RS15300	COG2837	iron assimilation
I6I95_RS15305	COG4150	thiosulfate binding
I6I95_RS15310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I95_RS15315	COG4208	sulfate ABC transporter
I6I95_RS15325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I95_RS15335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS15340	COG0745	RESPONSE REGULATOR receiver
I6I95_RS15345	COG2205	protein histidine kinase activity
I6I95_RS15355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I95_RS15360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I95_RS15370	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6I95_RS15375	COG3115	cell septum assembly
I6I95_RS15380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I95_RS15385	COG3530	Putative quorum-sensing-regulated virulence factor
I6I95_RS15390	COG0385	Bile acid
I6I95_RS15395	COG0583	DNA-binding transcription factor activity
I6I95_RS15410	COG4303	Ethanolamine ammonia lyase large subunit
I6I95_RS15415	COG4302	ethanolamine ammonia-lyase activity
I6I95_RS15435	COG0747	negative chemotaxis
I6I95_RS15440	COG4771	TonB-dependent receptor
I6I95_RS15445	COG2382	esterase
I6I95_RS15450	COG3251	PFAM MbtH domain protein
I6I95_RS15455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I95_RS15455	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I95_RS15460	COG1120	ATPase activity
I6I95_RS15465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I95_RS15470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I95_RS15480	COG4592	Periplasmic binding protein
I6I95_RS15485	COG1169	isochorismate synthase
I6I95_RS15490	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I95_RS15495	COG3433	isochorismatase activity
I6I95_RS15495	COG1535	isochorismatase
I6I95_RS15500	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS15525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I95_RS15540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I95_RS15545	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I95_RS15555	COG0667	Aldo Keto reductase
I6I95_RS15560	COG3961	Belongs to the TPP enzyme family
I6I95_RS15575	COG1794	racemase activity, acting on amino acids and derivatives
I6I95_RS15590	COG2223	nitrite transmembrane transporter activity
I6I95_RS15600	COG3279	Response regulator of the LytR AlgR family
I6I95_RS15605	COG3275	phosphorelay sensor kinase activity
I6I95_RS15620	COG0436	Aminotransferase
I6I95_RS15625	COG3038	cytochrome b561
I6I95_RS15640	COG1598	PFAM Uncharacterised protein family UPF0150
I6I95_RS15650	COG2951	lytic endotransglycosylase activity
I6I95_RS15665	COG0697	spore germination
I6I95_RS15675	COG0583	DNA-binding transcription factor activity
I6I95_RS15685	COG2116	formate transmembrane transporter activity
I6I95_RS15695	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I95_RS15700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I95_RS15705	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I95_RS15710	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I95_RS15715	COG1138	Cytochrome C-type biogenesis protein
I6I95_RS15720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I95_RS15725	COG3088	subunit of a heme lyase
I6I95_RS15725	COG4235	cytochrome complex assembly
I6I95_RS15730	COG4235	cytochrome complex assembly
I6I95_RS15730	COG3088	subunit of a heme lyase
I6I95_RS15740	COG2067	long-chain fatty acid transport protein
I6I95_RS15745	COG3691	Protein conserved in bacteria
I6I95_RS15750	COG0183	Belongs to the thiolase family
I6I95_RS15755	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I95_RS15755	COG1024	Enoyl-CoA hydratase
I6I95_RS15760	COG2062	phosphohistidine phosphatase, SixA
I6I95_RS15765	COG2840	Smr protein MutS2
I6I95_RS15770	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I95_RS15775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I95_RS15780	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6I95_RS15785	COG0730	response to heat
I6I95_RS15790	COG3101	peptidyl-lysine hydroxylation
I6I95_RS15800	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I95_RS15800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I95_RS15805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I95_RS15830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS15835	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I95_RS15845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I95_RS15850	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I95_RS15895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I95_RS15900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I95_RS15940	COG0642	Histidine kinase
I6I95_RS15945	COG0697	spore germination
I6I95_RS15955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I95_RS15960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I95_RS15970	COG0586	Pfam SNARE associated Golgi protein
I6I95_RS15975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I95_RS15980	COG0285	dihydrofolate synthase activity
I6I95_RS15985	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6I95_RS15990	COG1286	toxin biosynthetic process
I6I95_RS15995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I95_RS16000	COG0163	prenyltransferase activity
I6I95_RS16005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS16010	COG4215	(ABC) transporter
I6I95_RS16020	COG4598	ABC transporter
I6I95_RS16025	COG1090	epimerase
I6I95_RS16030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I95_RS16035	COG0625	glutathione transferase activity
I6I95_RS16040	COG0622	Phosphoesterase
I6I95_RS16045	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I95_RS16050	COG0280	phosphate acetyltransferase
I6I95_RS16050	COG0857	belongs to the CobB CobQ family
I6I95_RS16055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I95_RS16060	COG3092	negative regulation of chromosome organization
I6I95_RS16065	COG3013	Belongs to the UPF0304 family
I6I95_RS16070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I95_RS16075	COG0471	metal ion transport
I6I95_RS16075	COG0490	domain, Protein
I6I95_RS16080	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6I95_RS16085	COG0436	Aminotransferase
I6I95_RS16090	COG0583	DNA-binding transcription factor activity
I6I95_RS16095	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I95_RS16100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I95_RS16105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I95_RS16105	COG0649	NAD binding
I6I95_RS16120	COG1034	ATP synthesis coupled electron transport
I6I95_RS16125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I95_RS16135	COG0839	Belongs to the complex I subunit 6 family
I6I95_RS16140	COG0713	ATP synthesis coupled electron transport
I6I95_RS16145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I95_RS16150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I95_RS16155	COG1007	ATP synthesis coupled electron transport
I6I95_RS16165	COG0028	Belongs to the TPP enzyme family
I6I95_RS16195	COG1609	Transcriptional regulator
I6I95_RS16200	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS16205	COG1063	alcohol dehydrogenase
I6I95_RS16210	COG4575	ribosome binding
I6I95_RS16215	COG3459	Glycosyltransferase 36 associated
I6I95_RS16220	COG1169	isochorismate synthase
I6I95_RS16225	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I95_RS16230	COG0596	Alpha beta hydrolase
I6I95_RS16235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I95_RS16260	COG0814	amino acid
I6I95_RS16275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I95_RS16285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I95_RS16290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I95_RS16300	COG2205	protein histidine kinase activity
I6I95_RS16300	COG0784	Response regulator, receiver
I6I95_RS16310	COG0642	Histidine kinase
I6I95_RS16310	COG2198	Histidine kinase
I6I95_RS16315	COG2223	nitrite transmembrane transporter activity
I6I95_RS16330	COG0346	lactoylglutathione lyase activity
I6I95_RS16355	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I95_RS16385	COG3082	Protein of unknown function (DUF1414)
I6I95_RS16390	COG3081	Nucleoid-associated protein
I6I95_RS16395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I95_RS16400	COG1061	Type III restriction enzyme res subunit
I6I95_RS16405	COG1187	pseudouridine synthase activity
I6I95_RS16410	COG2814	Major facilitator Superfamily
I6I95_RS16420	COG4172	Belongs to the ABC transporter superfamily
I6I95_RS16425	COG4239	(ABC) transporter, permease
I6I95_RS16430	COG4174	ABC transporter (Permease)
I6I95_RS16435	COG4166	transmembrane transport
I6I95_RS16440	COG2200	EAL domain
I6I95_RS16445	COG0791	NLP P60 protein
I6I95_RS16450	COG0671	phosphoesterase, PA-phosphatase related
I6I95_RS16455	COG0523	cobalamin synthesis protein
I6I95_RS16465	COG0246	Mannitol dehydrogenase
I6I95_RS16470	COG1312	Catalyzes the dehydration of D-mannonate
I6I95_RS16475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I95_RS16495	COG0243	molybdopterin cofactor binding
I6I95_RS16500	COG3005	denitrification pathway
I6I95_RS16505	COG0494	nUDIX hydrolase
I6I95_RS16515	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I95_RS16520	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I95_RS16520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I95_RS16520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I95_RS16525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I95_RS16530	COG2855	membrane
I6I95_RS16535	COG0583	DNA-binding transcription factor activity
I6I95_RS16540	COG0833	amino acid
I6I95_RS16550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I95_RS16555	COG1120	ATPase activity
I6I95_RS16560	COG4771	TonB-dependent receptor
I6I95_RS16565	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS16570	COG1129	ABC transporter
I6I95_RS16575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I95_RS16580	COG1396	sequence-specific DNA binding
I6I95_RS16580	COG1917	Cupin 2, conserved barrel domain protein
I6I95_RS16585	COG0174	glutamine synthetase
I6I95_RS16590	COG0531	amino acid
I6I95_RS16595	COG2925	Exonuclease
I6I95_RS16620	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I95_RS16625	COG1289	transmembrane transporter activity
I6I95_RS16630	COG2926	Belongs to the UPF0265 family
I6I95_RS16635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS16640	COG1473	amidohydrolase
I6I95_RS16660	COG1309	transcriptional regulator
I6I95_RS16675	COG2814	Major facilitator Superfamily
I6I95_RS16685	COG1174	glycine betaine transport
I6I95_RS16700	COG2986	histidine ammonia-lyase
I6I95_RS16710	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I95_RS16765	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS16800	COG0583	DNA-binding transcription factor activity
I6I95_RS16805	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I95_RS16810	COG2207	Transcriptional regulator
I6I95_RS16815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6I95_RS16820	COG3477	response to acidic pH
I6I95_RS16830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I95_RS16835	COG0022	dehydrogenase e1 component
I6I95_RS16840	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I95_RS16845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I95_RS16850	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS16855	COG3547	Transposase (IS116 IS110 IS902 family)
I6I95_RS16865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I95_RS16925	COG0277	FAD linked oxidase domain protein
I6I95_RS16930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I95_RS16955	COG0402	S-adenosylhomocysteine deaminase activity
I6I95_RS16965	COG0583	DNA-binding transcription factor activity
I6I95_RS16990	COG4565	transcriptional regulatory protein
I6I95_RS16995	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6I95_RS17000	COG3052	prosthetic group binding
I6I95_RS17005	COG2301	Belongs to the HpcH HpaI aldolase family
I6I95_RS17010	COG3051	citrate lyase alpha subunit
I6I95_RS17025	COG0471	metal ion transport
I6I95_RS17055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I95_RS17060	COG1063	alcohol dehydrogenase
I6I95_RS17065	COG2271	Major facilitator Superfamily
I6I95_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS17080	COG2186	Transcriptional regulator
I6I95_RS17100	COG0601	transmembrane transport
I6I95_RS17105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I95_RS17110	COG4172	Belongs to the ABC transporter superfamily
I6I95_RS17115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS17130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS17145	COG0859	PFAM glycosyl transferase family 9
I6I95_RS17155	COG0583	DNA-binding transcription factor activity
I6I95_RS17175	COG3238	Protein conserved in bacteria
I6I95_RS17190	COG1183	phosphatidylcholine synthase activity
I6I95_RS17210	COG0436	Aminotransferase
I6I95_RS17225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I95_RS17265	COG2223	nitrite transmembrane transporter activity
I6I95_RS17270	COG4774	siderophore transport
I6I95_RS17310	COG0583	DNA-binding transcription factor activity
I6I95_RS17325	COG0583	DNA-binding transcription factor activity
I6I95_RS17340	COG2207	Transcriptional regulator
I6I95_RS17345	COG1881	PFAM PEBP family protein
I6I95_RS17400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I95_RS17405	COG0583	DNA-binding transcription factor activity
I6I95_RS17410	COG1486	melibiose metabolic process
I6I95_RS17415	COG3118	belongs to the thioredoxin family
I6I95_RS17420	COG2207	Transcriptional regulator
I6I95_RS17425	COG1881	PFAM PEBP family protein
I6I95_RS17430	COG1902	pentaerythritol trinitrate reductase activity
I6I95_RS17440	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS17460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I95_RS17465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I95_RS17485	COG3414	Phosphotransferase system galactitol-specific IIB component
I6I95_RS17490	COG3775	system Galactitol-specific IIC component
I6I95_RS17495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I95_RS17505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I95_RS17515	COG1129	ABC transporter
I6I95_RS17520	COG1879	ABC-type sugar transport system periplasmic component
I6I95_RS17525	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS17530	COG1070	Carbohydrate kinase
I6I95_RS17540	COG0477	Major facilitator Superfamily
I6I95_RS17545	COG0582	viral genome integration into host DNA
I6I95_RS17560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I95_RS17575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I95_RS17580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I95_RS17585	COG1116	anion transmembrane transporter activity
I6I95_RS17590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I95_RS17595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS17605	COG4977	sequence-specific DNA binding
I6I95_RS17610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I95_RS17620	COG3842	ATPase activity
I6I95_RS17630	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I95_RS17635	COG1609	Transcriptional regulator
I6I95_RS17640	COG3284	Transcriptional regulator
I6I95_RS17645	COG0095	Lipoate-protein ligase
I6I95_RS17650	COG1063	alcohol dehydrogenase
I6I95_RS17680	COG3706	GGDEF domain
I6I95_RS17690	COG1902	pentaerythritol trinitrate reductase activity
I6I95_RS17705	COG0604	alcohol dehydrogenase
I6I95_RS17715	COG3228	Belongs to the MtfA family
I6I95_RS17745	COG0673	inositol 2-dehydrogenase activity
I6I95_RS17765	COG0534	Mate efflux family protein
I6I95_RS17775	COG1486	melibiose metabolic process
I6I95_RS17780	COG2223	nitrite transmembrane transporter activity
I6I95_RS17790	COG4993	Dehydrogenase
I6I95_RS17830	COG0625	glutathione transferase activity
I6I95_RS17835	COG0583	DNA-binding transcription factor activity
I6I95_RS17855	COG1113	amino acid transport
I6I95_RS17860	COG0697	spore germination
I6I95_RS17875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I95_RS17880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I95_RS17885	COG3327	negative regulation of DNA-templated transcription, initiation
I6I95_RS17890	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6I95_RS17895	COG2050	protein possibly involved in aromatic compounds catabolism
I6I95_RS17900	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I95_RS17905	COG1024	Enoyl-CoA hydratase
I6I95_RS17910	COG1024	Enoyl-CoA hydratase
I6I95_RS17915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I95_RS17920	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I95_RS17925	COG3396	Phenylacetate-CoA oxygenase
I6I95_RS17930	COG3460	Phenylacetate-CoA oxygenase
I6I95_RS17935	COG3396	Phenylacetate-CoA oxygenase
I6I95_RS17940	COG2030	dehydratase
I6I95_RS17940	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS17945	COG5001	Diguanylate cyclase
I6I95_RS17945	COG2203	Gaf domain
I6I95_RS17945	COG3706	GGDEF domain
I6I95_RS17945	COG4251	negative regulation of phosphorylation
I6I95_RS17955	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6I95_RS17960	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS17965	COG0583	DNA-binding transcription factor activity
I6I95_RS17975	COG2261	transglycosylase associated protein
I6I95_RS17980	COG3753	Protein conserved in bacteria
I6I95_RS18000	COG0604	alcohol dehydrogenase
I6I95_RS18000	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS18000	COG3321	synthase
I6I95_RS18040	COG0583	DNA-binding transcription factor activity
I6I95_RS18045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I95_RS18055	COG1285	pathogenesis
I6I95_RS18095	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I95_RS18105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I95_RS18110	COG1393	Belongs to the ArsC family
I6I95_RS18115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I95_RS18120	COG0183	Belongs to the thiolase family
I6I95_RS18125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I95_RS18135	COG1414	Transcriptional regulator
I6I95_RS18140	COG4191	Histidine kinase
I6I95_RS18190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I95_RS18195	COG1609	Transcriptional regulator
I6I95_RS18200	COG2211	Major facilitator Superfamily
I6I95_RS18215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I95_RS18275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I95_RS18285	COG3483	tryptophan 2,3-dioxygenase activity
I6I95_RS18295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I95_RS18300	COG2130	NADP-dependent
I6I95_RS18335	COG0643	Histidine kinase
I6I95_RS18335	COG2198	Histidine kinase
I6I95_RS18340	COG0835	chemotaxis
I6I95_RS18350	COG0840	transmembrane signaling receptor activity
I6I95_RS18355	COG0840	transmembrane signaling receptor activity
I6I95_RS18360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I95_RS18370	COG0745	RESPONSE REGULATOR receiver
I6I95_RS18375	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I95_RS18380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I95_RS18385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I95_RS18395	COG3418	PFAM FlgN family protein
I6I95_RS18400	COG2747	anti-sigma28 factor FlgM
I6I95_RS18410	COG1815	bacterial-type flagellum-dependent cell motility
I6I95_RS18415	COG1558	bacterial-type flagellum-dependent cell motility
I6I95_RS18420	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I95_RS18425	COG1749	Flagellar hook protein flgE
I6I95_RS18435	COG4786	Flagellar basal body rod
I6I95_RS18455	COG1256	bacterial-type flagellum assembly
I6I95_RS18505	COG1580	Controls the rotational direction of flagella during chemotaxis
I6I95_RS18510	COG3144	bacterial-type flagellum assembly
I6I95_RS18515	COG2882	bacterial-type flagellum organization
I6I95_RS18520	COG1157	protein secretion by the type III secretion system
I6I95_RS18525	COG1317	bacterial-type flagellum organization
I6I95_RS18530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I95_RS18540	COG1677	Flagellar hook-basal body complex protein FliE
I6I95_RS18575	COG1191	sigma factor activity
I6I95_RS18585	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I95_RS18590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS18595	COG0765	amino acid transport
I6I95_RS18600	COG1126	abc transporter atp-binding protein
I6I95_RS18615	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I95_RS18615	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I95_RS18615	COG0506	proline dehydrogenase activity
I6I95_RS18630	COG0672	)-iron permease
I6I95_RS18645	COG4772	TonB-dependent receptor
I6I95_RS18650	COG1702	phosphate starvation-inducible protein PhoH
I6I95_RS18660	COG0387	Pfam Sodium calcium exchanger
I6I95_RS18665	COG2375	cellular response to nickel ion
I6I95_RS18670	COG4572	Cation transport regulator
I6I95_RS18675	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6I95_RS18680	COG0583	DNA-binding transcription factor activity
I6I95_RS18685	COG4166	transmembrane transport
I6I95_RS18690	COG0601	transmembrane transport
I6I95_RS18695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I95_RS18700	COG0444	Belongs to the ABC transporter superfamily
I6I95_RS18705	COG4608	Belongs to the ABC transporter superfamily
I6I95_RS18715	COG3707	response regulator
I6I95_RS18720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I95_RS18730	COG1116	anion transmembrane transporter activity
I6I95_RS18735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I95_RS18735	COG2146	nitrite reductase [NAD(P)H] activity
I6I95_RS18740	COG0243	molybdopterin cofactor binding
I6I95_RS18745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I95_RS18745	COG1648	precorrin-2 dehydrogenase activity
I6I95_RS18760	COG4932	domain protein
I6I95_RS18765	COG2197	response regulator
I6I95_RS18770	COG3850	Histidine kinase
I6I95_RS18775	COG2223	nitrite transmembrane transporter activity
I6I95_RS18780	COG3710	Transcriptional regulator
I6I95_RS18785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I95_RS18790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I95_RS18815	COG0463	Glycosyl transferase, family 2
I6I95_RS18825	COG1215	transferase activity, transferring glycosyl groups
I6I95_RS18835	COG1216	Glycosyl transferase, family 2
I6I95_RS18840	COG1216	Glycosyl transferase, family 2
I6I95_RS18840	COG0463	Glycosyl transferase, family 2
I6I95_RS18850	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I95_RS18855	COG1140	nitrate reductase beta subunit
I6I95_RS18860	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6I95_RS18865	COG2181	nitrate reductase activity
I6I95_RS18870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I95_RS18875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I95_RS18925	COG1294	oxidase, subunit
I6I95_RS18930	COG1271	oxidase subunit
I6I95_RS18935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I95_RS18945	COG0601	transmembrane transport
I6I95_RS18955	COG0444	Belongs to the ABC transporter superfamily
I6I95_RS18960	COG4608	Belongs to the ABC transporter superfamily
I6I95_RS18970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I95_RS18975	COG3138	arginine N-succinyltransferase
I6I95_RS18980	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS18985	COG3724	N-succinylarginine dihydrolase activity
I6I95_RS18990	COG2988	succinylglutamate desuccinylase activity
I6I95_RS19010	COG1652	LysM domain
I6I95_RS19035	COG2207	Transcriptional regulator
I6I95_RS19080	COG1113	amino acid transport
I6I95_RS19110	COG2226	methyltransferase
I6I95_RS19115	COG0640	Transcriptional regulator
I6I95_RS19125	COG1971	Probably functions as a manganese efflux pump
I6I95_RS19130	COG4811	Protein of unknown function (DUF986)
I6I95_RS19135	COG3716	PTS system mannose fructose sorbose family IID component
I6I95_RS19140	COG3715	PTS system
I6I95_RS19145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I95_RS19145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS19150	COG1253	flavin adenine dinucleotide binding
I6I95_RS19155	COG2200	EAL domain
I6I95_RS19160	COG1760	l-serine dehydratase
I6I95_RS19165	COG0494	nUDIX hydrolase
I6I95_RS19175	COG1216	Glycosyl transferase, family 2
I6I95_RS19180	COG3140	Belongs to the UPF0181 family
I6I95_RS19185	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I95_RS19190	COG0513	Belongs to the DEAD box helicase family
I6I95_RS19195	COG3141	response to X-ray
I6I95_RS19200	COG3097	Belongs to the UPF0267 family
I6I95_RS19220	COG2999	glutathione oxidoreductase activity
I6I95_RS19230	COG0477	Major facilitator Superfamily
I6I95_RS19235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I95_RS19240	COG3132	Protein of unknown function, DUF480
I6I95_RS19255	COG0018	arginyl-trna synthetase
I6I95_RS19260	COG3102	Protein conserved in bacteria
I6I95_RS19265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I95_RS19270	COG3142	Participates in the control of copper homeostasis
I6I95_RS19280	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I95_RS19285	COG0500	methyltransferase
I6I95_RS19290	COG2226	methyltransferase
I6I95_RS19295	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6I95_RS19300	COG1801	Protein of unknown function DUF72
I6I95_RS19305	COG1335	isochorismatase
I6I95_RS19315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I95_RS19320	COG0494	nUDIX hydrolase
I6I95_RS19325	COG0217	transcriptional regulatory protein
I6I95_RS19330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I95_RS19335	COG0632	four-way junction helicase activity
I6I95_RS19340	COG2255	four-way junction helicase activity
I6I95_RS19345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I95_RS19350	COG1121	(ABC) transporter
I6I95_RS19355	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6I95_RS19360	COG0739	heme binding
I6I95_RS19365	COG1560	Kdo2-lipid A biosynthetic process
I6I95_RS19375	COG0469	pyruvate kinase activity
I6I95_RS19380	COG1737	Transcriptional regulator
I6I95_RS19385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I95_RS19390	COG0800	Aldolase
I6I95_RS19395	COG2076	Multidrug Resistance protein
I6I95_RS19400	COG2076	Multidrug Resistance protein
I6I95_RS19405	COG0251	oxidation-reduction process
I6I95_RS19410	COG1199	ATP-dependent helicase activity
I6I95_RS19420	COG3065	identical protein binding
I6I95_RS19425	COG0318	PFAM AMP-dependent synthetase and ligase
I6I95_RS19430	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I95_RS19435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I95_RS19440	COG2894	cell division
I6I95_RS19445	COG0850	regulation of cytokinetic process
I6I95_RS19450	COG3100	YcgL domain-containing protein
I6I95_RS19455	COG2951	lytic endotransglycosylase activity
I6I95_RS19460	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I95_RS19470	COG2983	Belongs to the UPF0260 family
I6I95_RS19475	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I95_RS19480	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I95_RS19485	COG2186	Transcriptional regulator
I6I95_RS19490	COG2719	SpoVR family
I6I95_RS19495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I95_RS19500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I95_RS19515	COG0601	transmembrane transport
I6I95_RS19530	COG0444	Belongs to the ABC transporter superfamily
I6I95_RS19545	COG4774	siderophore transport
I6I95_RS19555	COG0401	homolog of Blt101
I6I95_RS19575	COG2718	Belongs to the UPF0229 family
I6I95_RS19580	COG2766	serine protein kinase
I6I95_RS19585	COG3713	MltA-interacting MipA family protein
I6I95_RS19595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I95_RS19600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I95_RS19605	COG3139	Protein of unknown function (DUF1315)
I6I95_RS19615	COG1335	isochorismatase
I6I95_RS19620	COG0252	asparaginase activity
I6I95_RS19625	COG0616	signal peptide processing
I6I95_RS19630	COG0778	Nitroreductase
I6I95_RS19645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I95_RS19655	COG0494	nUDIX hydrolase
I6I95_RS19660	COG0708	Exodeoxyribonuclease III
I6I95_RS19680	COG0788	formyltetrahydrofolate deformylase activity
I6I95_RS19685	COG3012	SEC-C Motif Domain Protein
I6I95_RS19690	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I95_RS19695	COG0745	RESPONSE REGULATOR receiver
I6I95_RS19700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I95_RS19725	COG1454	alcohol dehydrogenase
I6I95_RS19725	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS19730	COG2095	MarC family integral membrane protein
I6I95_RS19735	COG4166	transmembrane transport
I6I95_RS19750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I95_RS19755	COG0444	Belongs to the ABC transporter superfamily
I6I95_RS19765	COG3099	Belongs to the UPF0263 family
I6I95_RS19770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I95_RS19805	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I95_RS19810	COG2350	Protein conserved in bacteria
I6I95_RS19815	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I95_RS19825	COG1607	acyl-coa hydrolase
I6I95_RS19830	COG2917	probably involved in intracellular septation
I6I95_RS19845	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6I95_RS19850	COG3047	cAMP biosynthetic process
I6I95_RS19860	COG0159	tryptophan synthase activity
I6I95_RS19865	COG0133	tryptophan synthase activity
I6I95_RS19875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I95_RS19890	COG0613	PHP domain protein
I6I95_RS19895	COG0009	L-threonylcarbamoyladenylate synthase
I6I95_RS19910	COG1187	pseudouridine synthase activity
I6I95_RS19915	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6I95_RS19920	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS19925	COG0616	signal peptide processing
I6I95_RS19940	COG0583	DNA-binding transcription factor activity
I6I95_RS19950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I95_RS19960	COG0671	phosphoesterase, PA-phosphatase related
I6I95_RS19965	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6I95_RS19970	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I95_RS19990	COG0023	Translation Initiation Factor
I6I95_RS20000	COG0235	Class ii aldolase
I6I95_RS20005	COG1349	DNA-binding transcription factor activity
I6I95_RS20010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I95_RS20015	COG1966	Carbon starvation protein
I6I95_RS20020	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6I95_RS20025	COG0243	molybdopterin cofactor binding
I6I95_RS20040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I95_RS20040	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I95_RS20050	COG4172	Belongs to the ABC transporter superfamily
I6I95_RS20055	COG4171	peptide transport system, permease
I6I95_RS20060	COG4168	peptide transport system, permease
I6I95_RS20070	COG1469	GTP cyclohydrolase I activity
I6I95_RS20090	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6I95_RS20095	COG1842	Phage shock protein A
I6I95_RS20105	COG1983	PspC domain protein
I6I95_RS20120	COG3106	COG3106 Predicted ATPase
I6I95_RS20125	COG3768	UPF0283 membrane protein
I6I95_RS20135	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I95_RS20140	COG4948	Mandelate Racemase Muconate Lactonizing
I6I95_RS20145	COG2866	Carboxypeptidase
I6I95_RS20155	COG4166	transmembrane transport
I6I95_RS20175	COG0037	tRNA processing
I6I95_RS20195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I95_RS20195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I95_RS20195	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I95_RS20195	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I95_RS20205	COG3042	response to heat
I6I95_RS20210	COG3187	Heat shock protein
I6I95_RS20215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I95_RS20220	COG2911	Protein conserved in bacteria
I6I95_RS20230	COG3784	Protein of unknown function (DUF1318)
I6I95_RS20235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I95_RS20240	COG1643	Atp-dependent helicase
I6I95_RS20245	COG3591	Belongs to the peptidase S1B family
I6I95_RS20260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6I95_RS20265	COG2205	protein histidine kinase activity
I6I95_RS20270	COG0745	RESPONSE REGULATOR receiver
I6I95_RS20285	COG0531	amino acid
I6I95_RS20295	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6I95_RS20300	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6I95_RS20305	COG0589	response to stress
I6I95_RS20315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I95_RS20335	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6I95_RS20360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS20375	COG0306	phosphate transporter
I6I95_RS20435	COG3158	transport of potassium into the cell
I6I95_RS20460	COG0657	acetylesterase activity
I6I95_RS20490	COG0697	spore germination
I6I95_RS20495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I95_RS20515	COG0583	DNA-binding transcription factor activity
I6I95_RS20530	COG2239	Acts as a magnesium transporter
I6I95_RS20565	COG2207	Transcriptional regulator
I6I95_RS20565	COG1917	Cupin 2, conserved barrel domain protein
I6I95_RS20575	COG0488	(ABC) transporter
I6I95_RS20580	COG1196	nuclear chromosome segregation
I6I95_RS20580	COG3264	Mechanosensitive ion channel
I6I95_RS20590	COG1263	PTS System
I6I95_RS20590	COG2190	(PTS) system
I6I95_RS20590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS20595	COG0583	DNA-binding transcription factor activity
I6I95_RS20600	COG1653	transport
I6I95_RS20620	COG3842	ATPase activity
I6I95_RS20625	COG0366	Alpha amylase catalytic
I6I95_RS20635	COG1129	ABC transporter
I6I95_RS20640	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS20645	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS20655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I95_RS20675	COG2011	ABC-type metal ion transport system permease component
I6I95_RS20680	COG2199	diguanylate cyclase activity
I6I95_RS20685	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6I95_RS20700	COG3048	D-serine ammonia-lyase activity
I6I95_RS20705	COG1414	Transcriptional regulator
I6I95_RS20725	COG1082	Xylose isomerase domain protein TIM barrel
I6I95_RS20725	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6I95_RS20730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I95_RS20740	COG2814	Major facilitator Superfamily
I6I95_RS20755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I95_RS20760	COG0583	DNA-binding transcription factor activity
I6I95_RS20765	COG3485	protocatechuate 3,4-dioxygenase
I6I95_RS20770	COG3485	protocatechuate 3,4-dioxygenase
I6I95_RS20775	COG2723	6-phospho-beta-galactosidase activity
I6I95_RS20780	COG1737	Transcriptional regulator
I6I95_RS20785	COG2271	Major facilitator Superfamily
I6I95_RS20790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I95_RS20800	COG1045	serine acetyltransferase
I6I95_RS20805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I95_RS20810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I95_RS20820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I95_RS20825	COG2011	ABC-type metal ion transport system permease component
I6I95_RS20830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I95_RS20835	COG1464	Belongs to the NlpA lipoprotein family
I6I95_RS20860	COG0583	DNA-binding transcription factor activity
I6I95_RS20870	COG1396	sequence-specific DNA binding
I6I95_RS20875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I95_RS20880	COG3135	benzoate transporter
I6I95_RS20905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I95_RS20920	COG0693	protein deglycase activity
I6I95_RS20935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I95_RS20970	COG1733	regulation of RNA biosynthetic process
I6I95_RS20975	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I95_RS20980	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I95_RS20985	COG0583	DNA-binding transcription factor activity
I6I95_RS20990	COG1082	Xylose isomerase domain protein TIM barrel
I6I95_RS20995	COG0673	inositol 2-dehydrogenase activity
I6I95_RS21010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I95_RS21030	COG0702	epimerase
I6I95_RS21035	COG1733	regulation of RNA biosynthetic process
I6I95_RS21040	COG4221	oxidoreductase activity
I6I95_RS21050	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS21070	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I95_RS21075	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I95_RS21080	COG2211	Major facilitator Superfamily
I6I95_RS21095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I95_RS21110	COG4580	involved in the transport of maltose and maltodextrins
I6I95_RS21115	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I95_RS21120	COG2723	6-phospho-beta-galactosidase activity
I6I95_RS21125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I95_RS21125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I95_RS21135	COG1609	Transcriptional regulator
I6I95_RS21145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I95_RS21150	COG3713	MltA-interacting MipA family protein
I6I95_RS21185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I95_RS21190	COG0076	glutamate decarboxylase activity
I6I95_RS21210	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I95_RS21215	COG0426	domain, Protein
I6I95_RS21215	COG1773	rubredoxin
I6I95_RS21220	COG3604	Transcriptional regulator
I6I95_RS21235	COG2207	Transcriptional regulator
I6I95_RS21240	COG4993	Dehydrogenase
I6I95_RS21255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS21270	COG3284	Transcriptional regulator
I6I95_RS21300	COG1902	pentaerythritol trinitrate reductase activity
I6I95_RS21320	COG1522	sequence-specific DNA binding
I6I95_RS21345	COG0583	DNA-binding transcription factor activity
I6I95_RS21350	COG2814	Major facilitator Superfamily
I6I95_RS21360	COG3622	Belongs to the hyi family
I6I95_RS21365	COG0673	inositol 2-dehydrogenase activity
I6I95_RS21380	COG4558	Periplasmic binding protein
I6I95_RS21395	COG2862	Uncharacterized protein family, UPF0114
I6I95_RS21400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I95_RS21420	COG1309	transcriptional regulator
I6I95_RS21440	COG1874	Beta-galactosidase
I6I95_RS21450	COG3833	ABC-type maltose transport systems, permease component
I6I95_RS21455	COG1175	transmembrane transport
I6I95_RS21460	COG2182	Extracellular solute-binding protein
I6I95_RS21470	COG2315	Protein conserved in bacteria
I6I95_RS21530	COG1309	transcriptional regulator
I6I95_RS21540	COG0371	Dehydrogenase
I6I95_RS21560	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I95_RS21565	COG2814	Major facilitator Superfamily
I6I95_RS21575	COG2814	Major facilitator Superfamily
I6I95_RS21590	COG2079	MmgE PrpD family protein
I6I95_RS21595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS21605	COG0765	amino acid transport
I6I95_RS21610	COG1126	abc transporter atp-binding protein
I6I95_RS21635	COG0768	penicillin binding
I6I95_RS21650	COG0583	DNA-binding transcription factor activity
I6I95_RS21665	COG4608	Belongs to the ABC transporter superfamily
I6I95_RS21670	COG0444	Belongs to the ABC transporter superfamily
I6I95_RS21675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I95_RS21680	COG0601	transmembrane transport
I6I95_RS21685	COG0747	negative chemotaxis
I6I95_RS21690	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6I95_RS21700	COG3153	acetyltransferase
I6I95_RS21720	COG1215	transferase activity, transferring glycosyl groups
I6I95_RS21725	COG2814	Major facilitator Superfamily
I6I95_RS21760	COG0384	phenazine biosynthesis protein PhzF
I6I95_RS21770	COG3609	addiction module antidote protein, CC2985 family
I6I95_RS21795	COG3711	transcriptional antiterminator
I6I95_RS21800	COG2723	6-phospho-beta-galactosidase activity
I6I95_RS21805	COG1263	PTS System
I6I95_RS21805	COG2190	(PTS) system
I6I95_RS21805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS21825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I95_RS21840	COG2010	Cytochrome c
I6I95_RS21840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I95_RS21845	COG2080	2 iron, 2 sulfur cluster binding
I6I95_RS21850	COG1846	Transcriptional regulator
I6I95_RS21855	COG2309	aminopeptidase activity
I6I95_RS21860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I95_RS21865	COG0596	Alpha beta hydrolase
I6I95_RS21870	COG3473	Maleate cis-trans isomerase
I6I95_RS21875	COG1335	isochorismatase
I6I95_RS21880	COG2271	Major facilitator Superfamily
I6I95_RS21890	COG0339	signal peptide processing
I6I95_RS21900	COG0366	Alpha amylase catalytic
I6I95_RS21905	COG2188	Transcriptional regulator
I6I95_RS21925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I95_RS21935	COG0402	S-adenosylhomocysteine deaminase activity
I6I95_RS21940	COG1940	carbohydrate kinase activity
I6I95_RS21945	COG2182	Extracellular solute-binding protein
I6I95_RS21960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I95_RS21970	COG0477	Major facilitator Superfamily
I6I95_RS21975	COG0667	Aldo Keto reductase
I6I95_RS21985	COG4221	oxidoreductase activity
I6I95_RS21990	COG1742	UPF0060 membrane protein
I6I95_RS22005	COG0477	Major facilitator Superfamily
I6I95_RS22015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I95_RS22020	COG1940	carbohydrate kinase activity
I6I95_RS22025	COG0583	DNA-binding transcription factor activity
I6I95_RS22030	COG2814	Major facilitator Superfamily
I6I95_RS22045	COG2378	regulation of single-species biofilm formation
I6I95_RS22050	COG0583	DNA-binding transcription factor activity
I6I95_RS22060	COG0114	fumarate hydratase activity
I6I95_RS22070	COG5339	Protein conserved in bacteria
I6I95_RS22095	COG1609	Transcriptional regulator
I6I95_RS22100	COG1263	PTS System
I6I95_RS22100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS22105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I95_RS22115	COG0494	nUDIX hydrolase
I6I95_RS22120	COG1349	DNA-binding transcription factor activity
I6I95_RS22125	COG0205	6-phosphofructokinase activity
I6I95_RS22160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I95_RS22165	COG0385	Bile acid
I6I95_RS22170	COG0673	inositol 2-dehydrogenase activity
I6I95_RS22175	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I95_RS22180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I95_RS22185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I95_RS22200	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS22205	COG1129	ABC transporter
I6I95_RS22210	COG1879	ABC-type sugar transport system periplasmic component
I6I95_RS22215	COG1069	ribulokinase activity
I6I95_RS22220	COG2160	L-arabinose isomerase activity
I6I95_RS22230	COG4657	Part of a membrane complex involved in electron transport
I6I95_RS22235	COG2878	Part of a membrane complex involved in electron transport
I6I95_RS22240	COG4656	Part of a membrane complex involved in electron transport
I6I95_RS22245	COG2207	Transcriptional regulator
I6I95_RS22245	COG3708	Transcriptional regulator
I6I95_RS22255	COG4659	FMN binding
I6I95_RS22265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I95_RS22270	COG3507	Belongs to the glycosyl hydrolase 43 family
I6I95_RS22275	COG2211	Major facilitator Superfamily
I6I95_RS22285	COG3708	Transcriptional regulator
I6I95_RS22285	COG2207	Transcriptional regulator
I6I95_RS22290	COG2211	Major facilitator Superfamily
I6I95_RS22300	COG3104	oligopeptide transport
I6I95_RS22305	COG1505	serine-type exopeptidase activity
I6I95_RS22310	COG1396	sequence-specific DNA binding
I6I95_RS22315	COG3135	benzoate transporter
I6I95_RS22360	COG1418	mRNA catabolic process
I6I95_RS22375	COG0625	glutathione transferase activity
I6I95_RS22385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I95_RS22390	COG0259	pyridoxamine-phosphate oxidase activity
I6I95_RS22395	COG3895	Periplasmic Protein
I6I95_RS22400	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I95_RS22405	COG3133	Outer membrane lipoprotein
I6I95_RS22410	COG1846	Transcriptional regulator
I6I95_RS22420	COG1566	PFAM secretion protein HlyD family protein
I6I95_RS22425	COG1289	transmembrane transporter activity
I6I95_RS22435	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I95_RS22440	COG4989	oxidoreductase activity
I6I95_RS22445	COG3313	Fe-S protein
I6I95_RS22450	COG0583	DNA-binding transcription factor activity
I6I95_RS22460	COG2194	sulfuric ester hydrolase activity
I6I95_RS22465	COG1309	transcriptional regulator
I6I95_RS22470	COG1902	pentaerythritol trinitrate reductase activity
I6I95_RS22475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I95_RS22480	COG0346	lactoylglutathione lyase activity
I6I95_RS22490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I95_RS22495	COG0791	NLP P60 protein
I6I95_RS22505	COG1609	Transcriptional regulator
I6I95_RS22510	COG0583	DNA-binding transcription factor activity
I6I95_RS22515	COG2814	Major facilitator Superfamily
I6I95_RS22520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I95_RS22530	COG0307	riboflavin synthase, alpha
I6I95_RS22535	COG0534	Mate efflux family protein
I6I95_RS22575	COG1376	ErfK ybiS ycfS ynhG family protein
I6I95_RS22575	COG1388	LysM domain
I6I95_RS22580	COG2166	iron-sulfur cluster assembly
I6I95_RS22585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I95_RS22590	COG0719	Fe-S assembly protein
I6I95_RS22595	COG0396	ATPase activity
I6I95_RS22600	COG0719	Fe-S assembly protein
I6I95_RS22605	COG0316	Belongs to the HesB IscA family
I6I95_RS22615	COG2050	protein possibly involved in aromatic compounds catabolism
I6I95_RS22620	COG0277	FAD linked oxidase domain protein
I6I95_RS22620	COG0247	lactate metabolic process
I6I95_RS22625	COG0628	permease
I6I95_RS22630	COG0574	Belongs to the PEP-utilizing enzyme family
I6I95_RS22630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I95_RS22635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I95_RS22640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I95_RS22645	COG0386	Belongs to the glutathione peroxidase family
I6I95_RS22660	COG3720	iron ion transport
I6I95_RS22665	COG4558	Periplasmic binding protein
I6I95_RS22670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I95_RS22690	COG0095	Lipoate-protein ligase
I6I95_RS22695	COG0791	NLP P60 protein
I6I95_RS22700	COG2076	Multidrug Resistance protein
I6I95_RS22705	COG2076	Multidrug Resistance protein
I6I95_RS22710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I95_RS22715	COG0726	polysaccharide deacetylase
I6I95_RS22720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I95_RS22720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I95_RS22725	COG1215	transferase activity, transferring glycosyl groups
I6I95_RS22730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I95_RS22735	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6I95_RS22740	COG0386	Belongs to the glutathione peroxidase family
I6I95_RS22745	COG4139	cobalamin transport
I6I95_RS22755	COG0776	regulation of translation
I6I95_RS22765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I95_RS22775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I95_RS22780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I95_RS22790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I95_RS22825	COG0814	amino acid
I6I95_RS22855	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I95_RS22860	COG1121	(ABC) transporter
I6I95_RS22865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I95_RS22870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I95_RS22880	COG3001	Fructosamine kinase
I6I95_RS22895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I95_RS22900	COG1988	membrane-bound metal-dependent
I6I95_RS22905	COG1823	symporter activity
I6I95_RS22915	COG2814	Major facilitator Superfamily
I6I95_RS22920	COG0501	Belongs to the peptidase M48B family
I6I95_RS22930	COG0793	Belongs to the peptidase S41A family
I6I95_RS22935	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6I95_RS22940	COG1956	GAF domain-containing protein
I6I95_RS22945	COG2995	paraquat-inducible protein a
I6I95_RS22950	COG3008	intermembrane lipid transfer
I6I95_RS22955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I95_RS22955	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6I95_RS23015	COG3493	citrate carrier protein
I6I95_RS23020	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I95_RS23025	COG0402	S-adenosylhomocysteine deaminase activity
I6I95_RS23045	COG0477	Major facilitator Superfamily
I6I95_RS23055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I95_RS23065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I95_RS23080	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS23085	COG2211	Major facilitator Superfamily
I6I95_RS23100	COG0371	Dehydrogenase
I6I95_RS23110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I95_RS23115	COG1116	anion transmembrane transporter activity
I6I95_RS23120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I95_RS23125	COG2358	TRAP transporter, solute receptor (TAXI family
I6I95_RS23135	COG0402	S-adenosylhomocysteine deaminase activity
I6I95_RS23145	COG1228	amidohydrolase
I6I95_RS23160	COG1605	Chorismate mutase
I6I95_RS23190	COG0531	amino acid
I6I95_RS23195	COG0174	glutamine synthetase
I6I95_RS23200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I95_RS23205	COG1917	Cupin 2, conserved barrel domain protein
I6I95_RS23205	COG1396	sequence-specific DNA binding
I6I95_RS23210	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS23215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I95_RS23220	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS23225	COG0589	response to stress
I6I95_RS23230	COG1335	isochorismatase
I6I95_RS23240	COG1278	Cold shock
I6I95_RS23270	COG0673	inositol 2-dehydrogenase activity
I6I95_RS23295	COG0628	permease
I6I95_RS23310	COG3064	Membrane
I6I95_RS23315	COG0538	isocitrate dehydrogenase activity
I6I95_RS23325	COG0463	Glycosyl transferase, family 2
I6I95_RS23340	COG0538	isocitrate dehydrogenase activity
I6I95_RS23345	COG1187	pseudouridine synthase activity
I6I95_RS23355	COG0482	sulfurtransferase activity
I6I95_RS23360	COG2915	High frequency lysogenization protein hflD homolog
I6I95_RS23365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I95_RS23385	COG0745	RESPONSE REGULATOR receiver
I6I95_RS23395	COG2850	peptidyl-arginine hydroxylation
I6I95_RS23400	COG0583	DNA-binding transcription factor activity
I6I95_RS23410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I95_RS23415	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I95_RS23420	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I95_RS23425	COG1263	PTS System
I6I95_RS23425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS23430	COG1486	melibiose metabolic process
I6I95_RS23445	COG1940	carbohydrate kinase activity
I6I95_RS23450	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I95_RS23460	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I95_RS23475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I95_RS23480	COG4702	Belongs to the UPF0303 family
I6I95_RS23485	COG0659	secondary active sulfate transmembrane transporter activity
I6I95_RS23490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I95_RS23505	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I95_RS23510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I95_RS23515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I95_RS23525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I95_RS23530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I95_RS23535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I95_RS23545	COG0193	aminoacyl-tRNA hydrolase activity
I6I95_RS23550	COG0659	secondary active sulfate transmembrane transporter activity
I6I95_RS23555	COG0012	GTP binding
I6I95_RS23575	COG0740	serine-type endopeptidase activity
I6I95_RS23595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I95_RS23600	COG2313	pseudouridylate synthase activity
I6I95_RS23605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I95_RS23610	COG0589	response to stress
I6I95_RS23620	COG1464	Belongs to the NlpA lipoprotein family
I6I95_RS23630	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I95_RS23635	COG1129	ABC transporter
I6I95_RS23650	COG3290	protein histidine kinase activity
I6I95_RS23655	COG4565	transcriptional regulatory protein
I6I95_RS23660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I95_RS23690	COG3655	Transcriptional regulator
I6I95_RS23700	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I95_RS23730	COG4771	TonB-dependent receptor
I6I95_RS23740	COG0745	RESPONSE REGULATOR receiver
I6I95_RS23750	COG1276	copper resistance
I6I95_RS23755	COG2372	response to copper ion
I6I95_RS23760	COG1528	Iron-storage protein
I6I95_RS23780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I95_RS23785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I95_RS23790	COG1770	oligopeptidase
I6I95_RS23795	COG2979	Protein of unknown function (DUF533)
I6I95_RS23800	COG3381	protein complex oligomerization
I6I95_RS23805	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I95_RS23810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I95_RS23840	COG3708	Transcriptional regulator
I6I95_RS23840	COG2207	Transcriptional regulator
I6I95_RS23845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS23865	COG3134	Outer membrane lipoprotein
I6I95_RS23870	COG1252	NADH dehydrogenase
I6I95_RS23875	COG3150	esterase
I6I95_RS23890	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6I95_RS23895	COG5633	Lipoprotein
I6I95_RS23900	COG0537	adenosine 5'-monophosphoramidase activity
I6I95_RS23905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I95_RS23910	COG1733	regulation of RNA biosynthetic process
I6I95_RS23915	COG1028	Short-chain dehydrogenase reductase Sdr
I6I95_RS23930	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I95_RS23935	COG1321	iron dependent repressor
I6I95_RS23940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I95_RS23940	COG1263	PTS System
I6I95_RS23945	COG0084	hydrolase, TatD family'
I6I95_RS23950	COG0470	DNA polymerase III
I6I95_RS23955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I95_RS23960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I95_RS23965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I95_RS23975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I95_RS23980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I95_RS23990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I95_RS23995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I95_RS24000	COG0416	fatty acid biosynthetic process
I6I95_RS24005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I95_RS24010	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I95_RS24020	COG0564	pseudouridine synthase activity
I6I95_RS24025	COG1530	ribonuclease E activity
I6I95_RS24030	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I95_RS24035	COG0418	dihydroorotase activity
I6I95_RS24070	COG0628	permease
I6I95_RS24075	COG3038	cytochrome b561
I6I95_RS24080	COG2353	YceI-like domain
I6I95_RS24085	COG1054	Belongs to the UPF0176 family
I6I95_RS24090	COG1902	pentaerythritol trinitrate reductase activity
I6I95_RS24100	COG1560	Kdo2-lipid A biosynthetic process
I6I95_RS24110	COG2814	Major facilitator Superfamily
I6I95_RS24120	COG0346	lactoylglutathione lyase activity
I6I95_RS24125	COG2391	methyltransferase activity
I6I95_RS24135	COG0640	Transcriptional regulator
I6I95_RS24145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I95_RS24160	COG5645	(Lipo)protein
I6I95_RS24165	COG2943	transferase activity, transferring hexosyl groups
I6I95_RS24170	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6I95_RS24190	COG3263	regulation of cellular component size
I6I95_RS24210	COG0322	excinuclease ABC activity
I6I95_RS24215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS24230	COG0477	Major facilitator Superfamily
I6I95_RS24270	COG0322	excinuclease ABC activity
I6I95_RS24275	COG2197	response regulator
I6I95_RS24285	COG3136	membrane protein required for alginate biosynthesis
I6I95_RS24320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I95_RS24335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I95_RS24340	COG1012	belongs to the aldehyde dehydrogenase family
I6I95_RS24345	COG0531	amino acid
I6I95_RS24355	COG0589	response to stress
I6I95_RS24360	COG2197	response regulator
I6I95_RS24365	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I95_RS24375	COG0156	8-amino-7-oxononanoate synthase activity
I6I95_RS24380	COG2814	Major facilitator Superfamily
I6I95_RS24410	COG1113	amino acid transport
I6I95_RS24415	COG1309	transcriptional regulator
I6I95_RS24420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS24425	COG1335	isochorismatase
I6I95_RS24430	COG0251	oxidation-reduction process
I6I95_RS24435	COG2267	carboxylic ester hydrolase activity
I6I95_RS24440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I95_RS24445	COG2233	PERMEase
I6I95_RS24475	COG1280	lysine exporter protein (LysE YggA)
I6I95_RS24480	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I95_RS24505	COG0670	Belongs to the BI1 family
I6I95_RS24510	COG2920	part of a sulfur-relay system
I6I95_RS24515	COG1254	Belongs to the acylphosphatase family
I6I95_RS24520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I95_RS24525	COG3785	DNA binding
I6I95_RS24530	COG1832	CoA-binding protein
I6I95_RS24540	COG1803	Methylglyoxal synthase
I6I95_RS24545	COG0210	DNA helicase
I6I95_RS24550	COG3304	Inner membrane component domain
I6I95_RS24555	COG1289	transmembrane transporter activity
I6I95_RS24560	COG3070	regulator of competence-specific genes
I6I95_RS24565	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
I6I95_RS24575	COG3120	sequence-specific DNA binding
I6I95_RS24580	COG1067	ATP-dependent peptidase activity
I6I95_RS24585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I95_RS24595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I95_RS24600	COG3130	regulation of translation
I6I95_RS24605	COG3009	Protein conserved in bacteria
I6I95_RS24610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I95_RS24610	COG3008	intermembrane lipid transfer
I6I95_RS24615	COG2995	paraquat-inducible protein a
I6I95_RS24620	COG0488	(ABC) transporter
I6I95_RS24625	COG0116	Belongs to the methyltransferase superfamily
I6I95_RS24625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I95_RS24630	COG0633	Ferredoxin
I6I95_RS24630	COG3217	Mosc domain protein beta barrel domain protein
I6I95_RS24640	COG0167	dihydroorotate dehydrogenase activity
I6I95_RS24645	COG0431	NADPH-dependent FMN reductase
I6I95_RS24650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I95_RS24655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I95_RS24660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I95_RS24670	COG0308	aminopeptidase N
I6I95_RS24680	COG3706	GGDEF domain
I6I95_RS24685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I95_RS24690	COG0017	Asparaginyl-tRNA synthetase
I6I95_RS24700	COG1448	Aminotransferase
I6I95_RS24705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I95_RS24710	COG3108	Peptidase M15
I6I95_RS24715	COG2989	Protein conserved in bacteria
I6I95_RS24720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I95_RS24730	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6I95_RS24735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I95_RS24740	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6I95_RS24745	COG3173	Aminoglycoside phosphotransferase
I6I95_RS24750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I95_RS24755	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I95_RS24760	COG3214	Protein conserved in bacteria
I6I95_RS24765	COG1278	Cold shock
I6I95_RS24775	COG5383	Protein conserved in bacteria
I6I95_RS24780	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I95_RS24790	COG2333	competence protein COMEC
I6I95_RS24790	COG0658	competence protein
I6I95_RS24795	COG0776	regulation of translation
I6I95_RS24800	COG0539	negative regulation of cytoplasmic translation
I6I95_RS24805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I95_RS24810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I95_RS24815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I95_RS24835	COG0252	asparaginase activity
I6I95_RS24840	COG1944	ATP diphosphatase activity
I6I95_RS24845	COG2116	formate transmembrane transporter activity
I6I95_RS24850	COG1882	Formate acetyltransferase
I6I95_RS24855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I95_RS24880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I95_RS24885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I95_RS24890	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I95_RS24895	COG3107	peptidoglycan biosynthetic process
I6I95_RS24895	COG1674	ftsk spoiiie
I6I95_RS24905	COG0492	ferredoxin-NADP+ reductase activity
I6I95_RS24925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I95_RS24930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I95_RS24935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I95_RS24940	COG0542	response to heat
I6I95_RS24945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I95_RS24950	COG1278	Cold shock
I6I95_RS24960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I95_RS24965	COG2990	Protein conserved in bacteria
I6I95_RS24970	COG3593	DNA synthesis involved in DNA repair
I6I95_RS24975	COG2431	L-lysine efflux transmembrane transporter activity
I6I95_RS24980	COG1151	hydroxylamine reductase activity
I6I95_RS24985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I95_RS24990	COG0028	Belongs to the TPP enzyme family
I6I95_RS24995	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I95_RS25005	COG0702	epimerase
I6I95_RS25010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I95_RS25015	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I95_RS25025	COG0393	Putative heavy-metal-binding
I6I95_RS25035	COG1522	sequence-specific DNA binding
I6I95_RS25045	COG1126	abc transporter atp-binding protein
I6I95_RS25050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS25055	COG4215	(ABC) transporter
I6I95_RS25060	COG4160	amino acid transport
I6I95_RS25065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I95_RS25070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I95_RS25080	COG1177	transmembrane transport
I6I95_RS25085	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I95_RS25090	COG3842	ATPase activity
I6I95_RS25095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I95_RS25105	COG0189	ligase activity
I6I95_RS25125	COG0569	domain protein
I6I95_RS25125	COG2985	domain, Protein
I6I95_RS25150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I95_RS25155	COG4574	serine-type endopeptidase inhibitor activity
I6I95_RS25170	COG0671	phosphoesterase, PA-phosphatase related
I6I95_RS25180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I95_RS25185	COG1349	DNA-binding transcription factor activity
I6I95_RS25190	COG0814	amino acid
I6I95_RS25195	COG1760	l-serine dehydratase
I6I95_RS25200	COG1686	Belongs to the peptidase S11 family
I6I95_RS25210	COG0626	cystathionine gamma-synthase activity
I6I95_RS25225	COG0625	glutathione transferase activity
I6I95_RS25230	COG2133	pyrroloquinoline quinone binding
I6I95_RS25240	COG0598	Magnesium transport protein CorA
I6I95_RS25260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I95_RS25270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I95_RS25280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I95_RS25295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I95_RS25300	COG0107	imidazoleglycerol-phosphate synthase activity
I6I95_RS25305	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I95_RS25305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I95_RS25315	COG0438	transferase activity, transferring glycosyl groups
I6I95_RS25315	COG1216	Glycosyl transferase, family 2
I6I95_RS25325	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I95_RS25350	COG1442	glycosyl transferase family 8
I6I95_RS25365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I95_RS25375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I95_RS25415	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I95_RS25490	COG3206	protein involved in exopolysaccharide biosynthesis
I6I95_RS25490	COG0489	protein tyrosine kinase activity
I6I95_RS25505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I95_RS25510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I95_RS25515	COG1253	flavin adenine dinucleotide binding
I6I95_RS25520	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I95_RS25525	COG2982	Protein involved in outer membrane biogenesis
I6I95_RS25530	COG0717	Belongs to the dCTP deaminase family
I6I95_RS25535	COG0572	uridine kinase
I6I95_RS25545	COG0489	protein tyrosine kinase activity
I6I95_RS25550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I95_RS25550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I95_RS25585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I95_RS25640	COG1846	Transcriptional regulator
I6I95_RS25645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family