locus-tag	class	description
I6G64_RS00035	COG1522	sequence-specific DNA binding
I6G64_RS00060	COG0583	DNA-binding transcription factor activity
I6G64_RS00065	COG2814	Major facilitator Superfamily
I6G64_RS00080	COG0673	inositol 2-dehydrogenase activity
I6G64_RS00095	COG4558	Periplasmic binding protein
I6G64_RS00110	COG2862	Uncharacterized protein family, UPF0114
I6G64_RS00115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G64_RS00135	COG1309	transcriptional regulator
I6G64_RS00155	COG1874	Beta-galactosidase
I6G64_RS00165	COG3833	ABC-type maltose transport systems, permease component
I6G64_RS00170	COG1175	transmembrane transport
I6G64_RS00175	COG2182	Extracellular solute-binding protein
I6G64_RS00185	COG2315	Protein conserved in bacteria
I6G64_RS00210	COG0583	DNA-binding transcription factor activity
I6G64_RS00260	COG1309	transcriptional regulator
I6G64_RS00270	COG0371	Dehydrogenase
I6G64_RS00310	COG2814	Major facilitator Superfamily
I6G64_RS00330	COG0583	DNA-binding transcription factor activity
I6G64_RS00335	COG2079	MmgE PrpD family protein
I6G64_RS00340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS00350	COG0765	amino acid transport
I6G64_RS00355	COG1126	abc transporter atp-binding protein
I6G64_RS00380	COG0768	penicillin binding
I6G64_RS00395	COG0583	DNA-binding transcription factor activity
I6G64_RS00410	COG4608	Belongs to the ABC transporter superfamily
I6G64_RS00415	COG0444	Belongs to the ABC transporter superfamily
I6G64_RS00420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G64_RS00425	COG0601	transmembrane transport
I6G64_RS00430	COG0747	negative chemotaxis
I6G64_RS00435	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6G64_RS00445	COG3153	acetyltransferase
I6G64_RS00455	COG1215	transferase activity, transferring glycosyl groups
I6G64_RS00460	COG2814	Major facilitator Superfamily
I6G64_RS00535	COG3711	transcriptional antiterminator
I6G64_RS00540	COG2723	6-phospho-beta-galactosidase activity
I6G64_RS00545	COG2190	(PTS) system
I6G64_RS00545	COG1263	PTS System
I6G64_RS00545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS00580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G64_RS00610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G64_RS00610	COG2010	Cytochrome c
I6G64_RS00615	COG2080	2 iron, 2 sulfur cluster binding
I6G64_RS00620	COG1846	Transcriptional regulator
I6G64_RS00625	COG2309	aminopeptidase activity
I6G64_RS00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G64_RS00635	COG0596	Alpha beta hydrolase
I6G64_RS00640	COG3473	Maleate cis-trans isomerase
I6G64_RS00645	COG1335	isochorismatase
I6G64_RS00650	COG2271	Major facilitator Superfamily
I6G64_RS00655	COG0339	signal peptide processing
I6G64_RS00665	COG0366	Alpha amylase catalytic
I6G64_RS00670	COG2188	Transcriptional regulator
I6G64_RS00690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G64_RS00700	COG0402	S-adenosylhomocysteine deaminase activity
I6G64_RS00705	COG3469	chitinase activity
I6G64_RS00710	COG3397	chitin binding
I6G64_RS00715	COG1940	carbohydrate kinase activity
I6G64_RS00720	COG2182	Extracellular solute-binding protein
I6G64_RS00735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G64_RS00745	COG0477	Major facilitator Superfamily
I6G64_RS00750	COG0667	Aldo Keto reductase
I6G64_RS00760	COG4221	oxidoreductase activity
I6G64_RS00765	COG1742	UPF0060 membrane protein
I6G64_RS00780	COG0477	Major facilitator Superfamily
I6G64_RS00790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G64_RS00795	COG1940	carbohydrate kinase activity
I6G64_RS00800	COG0583	DNA-binding transcription factor activity
I6G64_RS00805	COG2814	Major facilitator Superfamily
I6G64_RS00820	COG2378	regulation of single-species biofilm formation
I6G64_RS00825	COG0583	DNA-binding transcription factor activity
I6G64_RS00835	COG0114	fumarate hydratase activity
I6G64_RS00850	COG5339	Protein conserved in bacteria
I6G64_RS00875	COG1609	Transcriptional regulator
I6G64_RS00880	COG1263	PTS System
I6G64_RS00880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS00885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G64_RS00895	COG0494	nUDIX hydrolase
I6G64_RS00900	COG1349	DNA-binding transcription factor activity
I6G64_RS00905	COG0205	6-phosphofructokinase activity
I6G64_RS00940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G64_RS00945	COG0385	Bile acid
I6G64_RS00950	COG0673	inositol 2-dehydrogenase activity
I6G64_RS00955	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G64_RS00960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G64_RS00965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G64_RS00980	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS00985	COG1129	ABC transporter
I6G64_RS00990	COG1879	ABC-type sugar transport system periplasmic component
I6G64_RS00995	COG1069	ribulokinase activity
I6G64_RS01000	COG2160	L-arabinose isomerase activity
I6G64_RS01010	COG4657	Part of a membrane complex involved in electron transport
I6G64_RS01015	COG2878	Part of a membrane complex involved in electron transport
I6G64_RS01020	COG4656	Part of a membrane complex involved in electron transport
I6G64_RS01025	COG3708	Transcriptional regulator
I6G64_RS01025	COG2207	Transcriptional regulator
I6G64_RS01035	COG4659	FMN binding
I6G64_RS01045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G64_RS01050	COG3507	Belongs to the glycosyl hydrolase 43 family
I6G64_RS01055	COG2211	Major facilitator Superfamily
I6G64_RS01065	COG2207	Transcriptional regulator
I6G64_RS01065	COG3708	Transcriptional regulator
I6G64_RS01070	COG2211	Major facilitator Superfamily
I6G64_RS01080	COG3104	oligopeptide transport
I6G64_RS01085	COG1505	serine-type exopeptidase activity
I6G64_RS01090	COG1396	sequence-specific DNA binding
I6G64_RS01095	COG3135	benzoate transporter
I6G64_RS01105	COG4122	O-methyltransferase activity
I6G64_RS01145	COG1418	mRNA catabolic process
I6G64_RS01160	COG0625	glutathione transferase activity
I6G64_RS01170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G64_RS01175	COG0259	pyridoxamine-phosphate oxidase activity
I6G64_RS01180	COG3895	Periplasmic Protein
I6G64_RS01185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G64_RS01190	COG3133	Outer membrane lipoprotein
I6G64_RS01195	COG1846	Transcriptional regulator
I6G64_RS01205	COG1566	PFAM secretion protein HlyD family protein
I6G64_RS01220	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6G64_RS01225	COG4989	oxidoreductase activity
I6G64_RS01230	COG3313	Fe-S protein
I6G64_RS01235	COG0583	DNA-binding transcription factor activity
I6G64_RS01245	COG2194	sulfuric ester hydrolase activity
I6G64_RS01250	COG1309	transcriptional regulator
I6G64_RS01255	COG1902	pentaerythritol trinitrate reductase activity
I6G64_RS01260	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G64_RS01265	COG0346	lactoylglutathione lyase activity
I6G64_RS01275	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G64_RS01280	COG0791	NLP P60 protein
I6G64_RS01290	COG1609	Transcriptional regulator
I6G64_RS01295	COG0583	DNA-binding transcription factor activity
I6G64_RS01300	COG2814	Major facilitator Superfamily
I6G64_RS01305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G64_RS01315	COG0307	riboflavin synthase, alpha
I6G64_RS01320	COG0534	Mate efflux family protein
I6G64_RS01360	COG1376	ErfK ybiS ycfS ynhG family protein
I6G64_RS01360	COG1388	LysM domain
I6G64_RS01365	COG2166	iron-sulfur cluster assembly
I6G64_RS01370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G64_RS01375	COG0719	Fe-S assembly protein
I6G64_RS01380	COG0396	ATPase activity
I6G64_RS01385	COG0719	Fe-S assembly protein
I6G64_RS01390	COG0316	Belongs to the HesB IscA family
I6G64_RS01400	COG2050	protein possibly involved in aromatic compounds catabolism
I6G64_RS01405	COG0247	lactate metabolic process
I6G64_RS01405	COG0277	FAD linked oxidase domain protein
I6G64_RS01410	COG0628	permease
I6G64_RS01415	COG0574	Belongs to the PEP-utilizing enzyme family
I6G64_RS01415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G64_RS01425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G64_RS01430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G64_RS01435	COG0386	Belongs to the glutathione peroxidase family
I6G64_RS01450	COG3720	iron ion transport
I6G64_RS01455	COG4558	Periplasmic binding protein
I6G64_RS01460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G64_RS01480	COG0095	Lipoate-protein ligase
I6G64_RS01485	COG0791	NLP P60 protein
I6G64_RS01490	COG2076	Multidrug Resistance protein
I6G64_RS01495	COG2076	Multidrug Resistance protein
I6G64_RS01500	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G64_RS01505	COG0726	polysaccharide deacetylase
I6G64_RS01510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G64_RS01510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G64_RS01515	COG1215	transferase activity, transferring glycosyl groups
I6G64_RS01520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G64_RS01525	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6G64_RS01530	COG0386	Belongs to the glutathione peroxidase family
I6G64_RS01535	COG4139	cobalamin transport
I6G64_RS01545	COG0776	regulation of translation
I6G64_RS01555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G64_RS01565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G64_RS01570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G64_RS01580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G64_RS01600	COG0814	amino acid
I6G64_RS01630	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G64_RS01635	COG1121	(ABC) transporter
I6G64_RS01640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G64_RS01645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G64_RS01655	COG3001	Fructosamine kinase
I6G64_RS01670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G64_RS01675	COG1988	membrane-bound metal-dependent
I6G64_RS01680	COG1823	symporter activity
I6G64_RS01690	COG2814	Major facilitator Superfamily
I6G64_RS01695	COG0501	Belongs to the peptidase M48B family
I6G64_RS01705	COG0793	Belongs to the peptidase S41A family
I6G64_RS01715	COG1956	GAF domain-containing protein
I6G64_RS01720	COG2995	paraquat-inducible protein a
I6G64_RS01725	COG3008	intermembrane lipid transfer
I6G64_RS01730	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6G64_RS01730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G64_RS01790	COG3493	citrate carrier protein
I6G64_RS01795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6G64_RS01815	COG0477	Major facilitator Superfamily
I6G64_RS01825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G64_RS01835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G64_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS01855	COG2211	Major facilitator Superfamily
I6G64_RS01875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G64_RS01880	COG1116	anion transmembrane transporter activity
I6G64_RS01885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G64_RS01890	COG2358	TRAP transporter, solute receptor (TAXI family
I6G64_RS01900	COG0402	S-adenosylhomocysteine deaminase activity
I6G64_RS01910	COG1228	amidohydrolase
I6G64_RS01925	COG1605	Chorismate mutase
I6G64_RS01955	COG0531	amino acid
I6G64_RS01965	COG0174	glutamine synthetase
I6G64_RS01970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G64_RS01975	COG1396	sequence-specific DNA binding
I6G64_RS01975	COG1917	Cupin 2, conserved barrel domain protein
I6G64_RS01980	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS01985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G64_RS01990	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS01995	COG0589	response to stress
I6G64_RS02005	COG1278	Cold shock
I6G64_RS02035	COG0673	inositol 2-dehydrogenase activity
I6G64_RS02045	COG1609	Transcriptional regulator
I6G64_RS02050	COG0628	permease
I6G64_RS02065	COG0538	isocitrate dehydrogenase activity
I6G64_RS02080	COG0538	isocitrate dehydrogenase activity
I6G64_RS02085	COG1187	pseudouridine synthase activity
I6G64_RS02095	COG0482	sulfurtransferase activity
I6G64_RS02100	COG2915	High frequency lysogenization protein hflD homolog
I6G64_RS02105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G64_RS02140	COG0745	RESPONSE REGULATOR receiver
I6G64_RS02150	COG2850	peptidyl-arginine hydroxylation
I6G64_RS02155	COG0583	DNA-binding transcription factor activity
I6G64_RS02165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G64_RS02170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G64_RS02175	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G64_RS02180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS02180	COG1263	PTS System
I6G64_RS02185	COG1486	melibiose metabolic process
I6G64_RS02205	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G64_RS02215	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G64_RS02230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G64_RS02235	COG4702	Belongs to the UPF0303 family
I6G64_RS02240	COG0659	secondary active sulfate transmembrane transporter activity
I6G64_RS02245	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G64_RS02260	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G64_RS02265	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G64_RS02270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G64_RS02280	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G64_RS02285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G64_RS02290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G64_RS02300	COG0193	aminoacyl-tRNA hydrolase activity
I6G64_RS02305	COG0659	secondary active sulfate transmembrane transporter activity
I6G64_RS02310	COG0012	GTP binding
I6G64_RS02330	COG0740	serine-type endopeptidase activity
I6G64_RS02350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G64_RS02355	COG2313	pseudouridylate synthase activity
I6G64_RS02360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G64_RS02365	COG0589	response to stress
I6G64_RS02375	COG1464	Belongs to the NlpA lipoprotein family
I6G64_RS02385	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS02390	COG1129	ABC transporter
I6G64_RS02405	COG3290	protein histidine kinase activity
I6G64_RS02410	COG4565	transcriptional regulatory protein
I6G64_RS02415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G64_RS02440	COG3655	Transcriptional regulator
I6G64_RS02450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G64_RS02490	COG1276	copper resistance
I6G64_RS02495	COG2372	response to copper ion
I6G64_RS02500	COG1528	Iron-storage protein
I6G64_RS02520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G64_RS02525	COG1770	oligopeptidase
I6G64_RS02530	COG2979	Protein of unknown function (DUF533)
I6G64_RS02535	COG3381	protein complex oligomerization
I6G64_RS02540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G64_RS02545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G64_RS02575	COG2207	Transcriptional regulator
I6G64_RS02575	COG3708	Transcriptional regulator
I6G64_RS02580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS02600	COG3134	Outer membrane lipoprotein
I6G64_RS02605	COG1252	NADH dehydrogenase
I6G64_RS02610	COG3150	esterase
I6G64_RS02620	COG0510	thiamine kinase activity
I6G64_RS02625	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6G64_RS02630	COG5633	Lipoprotein
I6G64_RS02635	COG0537	adenosine 5'-monophosphoramidase activity
I6G64_RS02645	COG1733	regulation of RNA biosynthetic process
I6G64_RS02650	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS02665	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G64_RS02670	COG1321	iron dependent repressor
I6G64_RS02725	COG4695	Portal protein
I6G64_RS02735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS02735	COG1263	PTS System
I6G64_RS02740	COG0084	hydrolase, TatD family'
I6G64_RS02745	COG0470	DNA polymerase III
I6G64_RS02750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G64_RS02755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G64_RS02760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G64_RS02770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G64_RS02775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G64_RS02785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G64_RS02790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G64_RS02795	COG0416	fatty acid biosynthetic process
I6G64_RS02800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G64_RS02805	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G64_RS02815	COG0564	pseudouridine synthase activity
I6G64_RS02820	COG1530	ribonuclease E activity
I6G64_RS02825	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6G64_RS02830	COG0418	dihydroorotase activity
I6G64_RS02865	COG0628	permease
I6G64_RS02870	COG3038	cytochrome b561
I6G64_RS02875	COG2353	YceI-like domain
I6G64_RS02880	COG1054	Belongs to the UPF0176 family
I6G64_RS02885	COG1902	pentaerythritol trinitrate reductase activity
I6G64_RS02895	COG1560	Kdo2-lipid A biosynthetic process
I6G64_RS02905	COG2814	Major facilitator Superfamily
I6G64_RS02915	COG0346	lactoylglutathione lyase activity
I6G64_RS02920	COG2391	methyltransferase activity
I6G64_RS02930	COG0640	Transcriptional regulator
I6G64_RS02940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G64_RS02955	COG5645	(Lipo)protein
I6G64_RS02960	COG2943	transferase activity, transferring hexosyl groups
I6G64_RS02965	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6G64_RS02980	COG3263	regulation of cellular component size
I6G64_RS03000	COG0322	excinuclease ABC activity
I6G64_RS03005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS03020	COG0477	Major facilitator Superfamily
I6G64_RS03060	COG0322	excinuclease ABC activity
I6G64_RS03065	COG2197	response regulator
I6G64_RS03075	COG3136	membrane protein required for alginate biosynthesis
I6G64_RS03115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G64_RS03130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G64_RS03135	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS03140	COG0531	amino acid
I6G64_RS03150	COG0589	response to stress
I6G64_RS03155	COG2197	response regulator
I6G64_RS03160	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G64_RS03170	COG0156	8-amino-7-oxononanoate synthase activity
I6G64_RS03175	COG2814	Major facilitator Superfamily
I6G64_RS03205	COG1113	amino acid transport
I6G64_RS03210	COG1309	transcriptional regulator
I6G64_RS03215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS03220	COG1335	isochorismatase
I6G64_RS03225	COG0251	oxidation-reduction process
I6G64_RS03230	COG2267	carboxylic ester hydrolase activity
I6G64_RS03235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G64_RS03240	COG2233	PERMEase
I6G64_RS03270	COG1280	lysine exporter protein (LysE YggA)
I6G64_RS03275	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6G64_RS03285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G64_RS03300	COG1960	acyl-CoA dehydrogenase activity
I6G64_RS03305	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G64_RS03310	COG3848	Pyruvate phosphate dikinase
I6G64_RS03310	COG0574	Belongs to the PEP-utilizing enzyme family
I6G64_RS03315	COG0028	Belongs to the TPP enzyme family
I6G64_RS03325	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G64_RS03325	COG1414	Transcriptional regulator
I6G64_RS03330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G64_RS03335	COG0156	8-amino-7-oxononanoate synthase activity
I6G64_RS03340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G64_RS03345	COG3321	synthase
I6G64_RS03360	COG0778	Nitroreductase
I6G64_RS03375	COG0670	Belongs to the BI1 family
I6G64_RS03380	COG2920	part of a sulfur-relay system
I6G64_RS03385	COG1254	Belongs to the acylphosphatase family
I6G64_RS03390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G64_RS03395	COG3785	DNA binding
I6G64_RS03400	COG1832	CoA-binding protein
I6G64_RS03410	COG1803	Methylglyoxal synthase
I6G64_RS03415	COG0210	DNA helicase
I6G64_RS03420	COG3304	Inner membrane component domain
I6G64_RS03425	COG1289	transmembrane transporter activity
I6G64_RS03435	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
I6G64_RS03445	COG3120	sequence-specific DNA binding
I6G64_RS03450	COG1067	ATP-dependent peptidase activity
I6G64_RS03455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G64_RS03465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G64_RS03470	COG3130	regulation of translation
I6G64_RS03475	COG3009	Protein conserved in bacteria
I6G64_RS03480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G64_RS03480	COG3008	intermembrane lipid transfer
I6G64_RS03485	COG2995	paraquat-inducible protein a
I6G64_RS03490	COG0488	(ABC) transporter
I6G64_RS03495	COG0116	Belongs to the methyltransferase superfamily
I6G64_RS03495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G64_RS03500	COG3217	Mosc domain protein beta barrel domain protein
I6G64_RS03500	COG0633	Ferredoxin
I6G64_RS03510	COG0167	dihydroorotate dehydrogenase activity
I6G64_RS03515	COG0431	NADPH-dependent FMN reductase
I6G64_RS03520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G64_RS03525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS03530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G64_RS03540	COG0308	aminopeptidase N
I6G64_RS03545	COG3706	GGDEF domain
I6G64_RS03550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G64_RS03555	COG0017	Asparaginyl-tRNA synthetase
I6G64_RS03565	COG1448	Aminotransferase
I6G64_RS03570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G64_RS03575	COG3108	Peptidase M15
I6G64_RS03580	COG2989	Protein conserved in bacteria
I6G64_RS03585	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6G64_RS03595	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6G64_RS03600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G64_RS03605	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G64_RS03610	COG3173	Aminoglycoside phosphotransferase
I6G64_RS03615	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6G64_RS03620	COG2835	tetraacyldisaccharide 4'-kinase activity
I6G64_RS03625	COG3214	Protein conserved in bacteria
I6G64_RS03630	COG1278	Cold shock
I6G64_RS03640	COG5383	Protein conserved in bacteria
I6G64_RS03645	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G64_RS03655	COG0658	competence protein
I6G64_RS03655	COG2333	competence protein COMEC
I6G64_RS03660	COG0776	regulation of translation
I6G64_RS03665	COG0539	negative regulation of cytoplasmic translation
I6G64_RS03670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G64_RS03675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G64_RS03680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G64_RS03700	COG0252	asparaginase activity
I6G64_RS03705	COG1944	ATP diphosphatase activity
I6G64_RS03710	COG2116	formate transmembrane transporter activity
I6G64_RS03715	COG1882	Formate acetyltransferase
I6G64_RS03720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G64_RS03745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G64_RS03750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G64_RS03755	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G64_RS03760	COG1674	ftsk spoiiie
I6G64_RS03760	COG3107	peptidoglycan biosynthetic process
I6G64_RS03770	COG0492	ferredoxin-NADP+ reductase activity
I6G64_RS03775	COG0583	DNA-binding transcription factor activity
I6G64_RS03790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G64_RS03795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G64_RS03800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G64_RS03805	COG0542	response to heat
I6G64_RS03810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G64_RS03815	COG1278	Cold shock
I6G64_RS03825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS03830	COG2990	Protein conserved in bacteria
I6G64_RS03835	COG3593	DNA synthesis involved in DNA repair
I6G64_RS03840	COG2431	L-lysine efflux transmembrane transporter activity
I6G64_RS03845	COG1151	hydroxylamine reductase activity
I6G64_RS03850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G64_RS03855	COG0028	Belongs to the TPP enzyme family
I6G64_RS03860	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6G64_RS03870	COG0702	epimerase
I6G64_RS03875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G64_RS03880	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G64_RS03890	COG0393	Putative heavy-metal-binding
I6G64_RS03900	COG1522	sequence-specific DNA binding
I6G64_RS03910	COG1126	abc transporter atp-binding protein
I6G64_RS03915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS03920	COG4215	(ABC) transporter
I6G64_RS03925	COG4160	amino acid transport
I6G64_RS03930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS03945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G64_RS03955	COG1177	transmembrane transport
I6G64_RS03960	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G64_RS03965	COG3842	ATPase activity
I6G64_RS03970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G64_RS03980	COG0189	ligase activity
I6G64_RS04000	COG2985	domain, Protein
I6G64_RS04000	COG0569	domain protein
I6G64_RS04015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G64_RS04020	COG4574	serine-type endopeptidase inhibitor activity
I6G64_RS04035	COG0671	phosphoesterase, PA-phosphatase related
I6G64_RS04045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G64_RS04050	COG1349	DNA-binding transcription factor activity
I6G64_RS04055	COG0814	amino acid
I6G64_RS04060	COG1760	l-serine dehydratase
I6G64_RS04065	COG1686	Belongs to the peptidase S11 family
I6G64_RS04075	COG0626	cystathionine gamma-synthase activity
I6G64_RS04090	COG0625	glutathione transferase activity
I6G64_RS04105	COG0598	Magnesium transport protein CorA
I6G64_RS04125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G64_RS04135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G64_RS04145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G64_RS04160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G64_RS04165	COG0107	imidazoleglycerol-phosphate synthase activity
I6G64_RS04170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G64_RS04170	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G64_RS04175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G64_RS04215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G64_RS04225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G64_RS04295	COG2327	Polysaccharide pyruvyl transferase
I6G64_RS04300	COG3206	protein involved in exopolysaccharide biosynthesis
I6G64_RS04300	COG0489	protein tyrosine kinase activity
I6G64_RS04305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G64_RS04315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G64_RS04320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G64_RS04325	COG1253	flavin adenine dinucleotide binding
I6G64_RS04330	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G64_RS04335	COG2982	Protein involved in outer membrane biogenesis
I6G64_RS04340	COG0717	Belongs to the dCTP deaminase family
I6G64_RS04345	COG0572	uridine kinase
I6G64_RS04355	COG0489	protein tyrosine kinase activity
I6G64_RS04360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G64_RS04360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G64_RS04370	COG2814	Major facilitator Superfamily
I6G64_RS04375	COG1380	Effector of murein hydrolase LrgA
I6G64_RS04380	COG1346	cytolysis
I6G64_RS04385	COG0295	cytidine deaminase activity
I6G64_RS04390	COG0281	malic enzyme
I6G64_RS04395	COG2949	membrane
I6G64_RS04415	COG1609	Transcriptional regulator
I6G64_RS04420	COG2311	Membrane
I6G64_RS04425	COG0302	gtp cyclohydrolase
I6G64_RS04430	COG0477	Major facilitator Superfamily
I6G64_RS04435	COG0583	DNA-binding transcription factor activity
I6G64_RS04460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G64_RS04465	COG0601	transmembrane transport
I6G64_RS04470	COG0747	negative chemotaxis
I6G64_RS04475	COG4172	Belongs to the ABC transporter superfamily
I6G64_RS04480	COG1446	asparaginase
I6G64_RS04490	COG0303	'Molybdopterin
I6G64_RS04495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G64_RS04500	COG0488	(ABC) transporter
I6G64_RS04535	COG0640	Transcriptional regulator
I6G64_RS04540	COG0625	glutathione transferase activity
I6G64_RS04565	COG0579	oxidoreductase
I6G64_RS04570	COG3708	Transcriptional regulator
I6G64_RS04570	COG2207	Transcriptional regulator
I6G64_RS04590	COG3539	Fimbrial protein
I6G64_RS04595	COG2200	EAL domain
I6G64_RS04605	COG0069	glutamate synthase activity
I6G64_RS04610	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G64_RS04615	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS04620	COG1309	transcriptional regulator
I6G64_RS04625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G64_RS04655	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6G64_RS04660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G64_RS04670	COG3622	Belongs to the hyi family
I6G64_RS04680	COG0583	DNA-binding transcription factor activity
I6G64_RS04685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G64_RS04690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G64_RS04700	COG2731	YhcH YjgK YiaL family protein
I6G64_RS04705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G64_RS04705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G64_RS04715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G64_RS04720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS04725	COG0765	amino acid transport
I6G64_RS04730	COG1126	abc transporter atp-binding protein
I6G64_RS04735	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6G64_RS04740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G64_RS04755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G64_RS04765	COG0477	Major facilitator Superfamily
I6G64_RS04775	COG1280	lysine exporter protein (LysE YggA)
I6G64_RS04780	COG0583	DNA-binding transcription factor activity
I6G64_RS04785	COG0477	Major facilitator Superfamily
I6G64_RS04790	COG0697	spore germination
I6G64_RS04795	COG1522	sequence-specific DNA binding
I6G64_RS04800	COG1199	ATP-dependent helicase activity
I6G64_RS04805	COG1942	4-Oxalocrotonate Tautomerase
I6G64_RS04810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G64_RS04825	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6G64_RS04875	COG0697	spore germination
I6G64_RS04885	COG0583	DNA-binding transcription factor activity
I6G64_RS04910	COG1174	glycine betaine transport
I6G64_RS04915	COG1125	glycine betaine transport
I6G64_RS04920	COG1174	glycine betaine transport
I6G64_RS04925	COG1732	Glycine betaine
I6G64_RS04945	COG0583	DNA-binding transcription factor activity
I6G64_RS04950	COG1335	isochorismatase
I6G64_RS04965	COG0625	glutathione transferase activity
I6G64_RS04975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G64_RS04990	COG1683	Conserved Protein
I6G64_RS05000	COG2897	thiosulfate sulfurtransferase activity
I6G64_RS05005	COG0583	DNA-binding transcription factor activity
I6G64_RS05035	COG3511	phospholipase C
I6G64_RS05075	COG1802	Transcriptional regulator
I6G64_RS05090	COG4807	Protein conserved in bacteria
I6G64_RS05095	COG3639	organic phosphonate transmembrane transporter activity
I6G64_RS05105	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6G64_RS05115	COG1063	alcohol dehydrogenase
I6G64_RS05120	COG1802	Transcriptional regulator
I6G64_RS05125	COG2271	Major facilitator Superfamily
I6G64_RS05130	COG2378	regulation of single-species biofilm formation
I6G64_RS05155	COG2801	Transposase and inactivated derivatives
I6G64_RS05180	COG0583	DNA-binding transcription factor activity
I6G64_RS05190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G64_RS05195	COG2011	ABC-type metal ion transport system permease component
I6G64_RS05200	COG1464	Belongs to the NlpA lipoprotein family
I6G64_RS05205	COG1309	transcriptional regulator
I6G64_RS05220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G64_RS05240	COG0366	Alpha amylase catalytic
I6G64_RS05265	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6G64_RS05270	COG1070	Carbohydrate kinase
I6G64_RS05280	COG0583	DNA-binding transcription factor activity
I6G64_RS05295	COG1192	Involved in chromosome partitioning
I6G64_RS05310	COG2267	carboxylic ester hydrolase activity
I6G64_RS05325	COG2226	methyltransferase
I6G64_RS05330	COG0717	Belongs to the dCTP deaminase family
I6G64_RS05335	COG0717	Belongs to the dCTP deaminase family
I6G64_RS05350	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G64_RS05375	COG1472	Belongs to the glycosyl hydrolase 3 family
I6G64_RS05385	COG0436	Aminotransferase
I6G64_RS05395	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G64_RS05410	COG0277	FAD linked oxidase domain protein
I6G64_RS05415	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS05430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G64_RS05445	COG1464	Belongs to the NlpA lipoprotein family
I6G64_RS05460	COG0697	spore germination
I6G64_RS05470	COG2354	Protein conserved in bacteria
I6G64_RS05485	COG1686	Belongs to the peptidase S11 family
I6G64_RS05490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6G64_RS05525	COG0586	Pfam SNARE associated Golgi protein
I6G64_RS05530	COG1280	lysine exporter protein (LysE YggA)
I6G64_RS05535	COG0583	DNA-binding transcription factor activity
I6G64_RS05555	COG0583	DNA-binding transcription factor activity
I6G64_RS05650	COG3539	Fimbrial protein
I6G64_RS05655	COG3121	Chaperone
I6G64_RS05660	COG3188	usher protein
I6G64_RS05685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G64_RS05690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G64_RS05695	COG0513	Belongs to the DEAD box helicase family
I6G64_RS05700	COG1309	transcriptional regulator
I6G64_RS05705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS05710	COG1131	(ABC) transporter
I6G64_RS05715	COG0842	Transport permease protein
I6G64_RS05720	COG0842	Transport permease protein
I6G64_RS05725	COG0670	Belongs to the BI1 family
I6G64_RS05730	COG0314	molybdopterin synthase activity
I6G64_RS05735	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G64_RS05740	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G64_RS05745	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G64_RS05750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G64_RS05755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G64_RS05760	COG4628	conserved protein (DUF2132)
I6G64_RS05765	COG0556	nucleotide-excision repair
I6G64_RS05790	COG0156	8-amino-7-oxononanoate synthase activity
I6G64_RS05795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G64_RS05810	COG1881	PFAM PEBP family protein
I6G64_RS05815	COG2706	6-phosphogluconolactonase activity
I6G64_RS05820	COG0561	phosphatase activity
I6G64_RS05830	COG4149	molybdate abc transporter
I6G64_RS05835	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G64_RS05845	COG3585	molybdate ion transport
I6G64_RS05845	COG2005	Transcriptional regulator
I6G64_RS05850	COG1119	ATPase activity
I6G64_RS05865	COG1085	galactose-1-phosphate uridylyltransferase
I6G64_RS05870	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G64_RS05875	COG2017	converts alpha-aldose to the beta-anomer
I6G64_RS05885	COG0588	phosphoglycerate mutase activity
I6G64_RS05915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G64_RS05920	COG2197	response regulator
I6G64_RS05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS05925	COG2205	protein histidine kinase activity
I6G64_RS05930	COG1230	cation diffusion facilitator family transporter
I6G64_RS05940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G64_RS05990	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G64_RS05995	COG2885	chlorophyll binding
I6G64_RS06000	COG0823	Involved in the tonB-independent uptake of proteins
I6G64_RS06005	COG3064	Membrane
I6G64_RS06010	COG0848	biopolymer transport protein
I6G64_RS06015	COG0811	peptide transport
I6G64_RS06020	COG0824	Thioesterase
I6G64_RS06025	COG3790	cyd operon protein YbgE
I6G64_RS06030	COG4890	Cyd operon protein YbgT
I6G64_RS06035	COG1294	oxidase, subunit
I6G64_RS06040	COG1271	oxidase subunit
I6G64_RS06045	COG0737	Belongs to the 5'-nucleotidase family
I6G64_RS06050	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G64_RS06055	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G64_RS06060	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G64_RS06065	COG0567	Dehydrogenase, E1 component
I6G64_RS06070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G64_RS06080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G64_RS06095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G64_RS06115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6G64_RS06120	COG1984	allophanate hydrolase subunit 2
I6G64_RS06125	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G64_RS06130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G64_RS06135	COG5212	phosphodiesterase
I6G64_RS06145	COG3272	Protein of unknown function (DUF1722)
I6G64_RS06160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G64_RS06165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G64_RS06170	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6G64_RS06175	COG2205	protein histidine kinase activity
I6G64_RS06180	COG0745	RESPONSE REGULATOR receiver
I6G64_RS06190	COG1695	Transcriptional regulator
I6G64_RS06195	COG0033	Phosphoglucomutase
I6G64_RS06200	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6G64_RS06205	COG0596	Alpha beta hydrolase
I6G64_RS06220	COG0735	belongs to the Fur family
I6G64_RS06240	COG0366	Alpha amylase catalytic
I6G64_RS06245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G64_RS06250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G64_RS06255	COG3848	Pyruvate phosphate dikinase
I6G64_RS06255	COG0574	Belongs to the PEP-utilizing enzyme family
I6G64_RS06270	COG2814	Major facilitator Superfamily
I6G64_RS06290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G64_RS06295	COG1263	PTS System
I6G64_RS06295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS06295	COG2190	(PTS) system
I6G64_RS06300	COG0363	glucosamine-6-phosphate deaminase activity
I6G64_RS06305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G64_RS06310	COG1940	carbohydrate kinase activity
I6G64_RS06310	COG1846	Transcriptional regulator
I6G64_RS06315	COG0647	UMP catabolic process
I6G64_RS06320	COG3469	chitinase activity
I6G64_RS06325	COG0367	asparagine synthase
I6G64_RS06360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G64_RS06365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G64_RS06370	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G64_RS06375	COG1702	phosphate starvation-inducible protein PhoH
I6G64_RS06380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G64_RS06385	COG4535	Mg2 and Co2 transporter CorC
I6G64_RS06390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G64_RS06400	COG0765	amino acid transport
I6G64_RS06405	COG0765	amino acid transport
I6G64_RS06410	COG1126	abc transporter atp-binding protein
I6G64_RS06415	COG1957	nucleoside hydrolase
I6G64_RS06425	COG2888	peptidyl-tyrosine sulfation
I6G64_RS06430	COG0495	leucyl-tRNA aminoacylation
I6G64_RS06435	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6G64_RS06440	COG1466	dna polymerase III delta subunit
I6G64_RS06445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G64_RS06450	COG0799	negative regulation of ribosome biogenesis
I6G64_RS06455	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G64_RS06460	COG0768	penicillin binding
I6G64_RS06465	COG0772	Belongs to the SEDS family
I6G64_RS06470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G64_RS06475	COG1686	Belongs to the peptidase S11 family
I6G64_RS06480	COG2921	Belongs to the UPF0250 family
I6G64_RS06485	COG0321	lipoyl(octanoyl) transferase activity
I6G64_RS06490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G64_RS06500	COG3706	GGDEF domain
I6G64_RS06510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G64_RS06520	COG2814	Major facilitator Superfamily
I6G64_RS06530	COG1473	amidohydrolase
I6G64_RS06535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS06545	COG0765	amino acid transport
I6G64_RS06550	COG1126	abc transporter atp-binding protein
I6G64_RS06560	COG1278	Cold shock
I6G64_RS06570	COG2199	diguanylate cyclase activity
I6G64_RS06580	COG0583	DNA-binding transcription factor activity
I6G64_RS06585	COG0667	Aldo Keto reductase
I6G64_RS06600	COG3423	Transcriptional regulator
I6G64_RS06615	COG0384	phenazine biosynthesis protein PhzF
I6G64_RS06720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G64_RS06725	COG2501	S4 domain
I6G64_RS06730	COG0215	cysteine-tRNA ligase activity
I6G64_RS06735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G64_RS06740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G64_RS06745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G64_RS06750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G64_RS06760	COG2814	Major facilitator Superfamily
I6G64_RS06765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G64_RS06770	COG4181	ATPase activity
I6G64_RS06775	COG2755	lipolytic protein G-D-S-L family
I6G64_RS06780	COG0300	oxidoreductase activity
I6G64_RS06785	COG3118	belongs to the thioredoxin family
I6G64_RS06790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G64_RS06795	COG0330	HflC and HflK could
I6G64_RS06800	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G64_RS06805	COG0789	Transcriptional regulator
I6G64_RS06810	COG2217	Heavy metal translocating P-type atpase
I6G64_RS06815	COG3735	TraB family
I6G64_RS06820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G64_RS06840	COG0737	Belongs to the 5'-nucleotidase family
I6G64_RS06845	COG2223	nitrite transmembrane transporter activity
I6G64_RS06850	COG4651	solute:proton antiporter activity
I6G64_RS06850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G64_RS06855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G64_RS06860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G64_RS06865	COG0563	adenylate kinase activity
I6G64_RS06870	COG0326	Molecular chaperone. Has ATPase activity
I6G64_RS06875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G64_RS06885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G64_RS06890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G64_RS06895	COG2832	Protein of unknown function (DUF454)
I6G64_RS06910	COG1196	nuclear chromosome segregation
I6G64_RS06910	COG3264	Mechanosensitive ion channel
I6G64_RS06915	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G64_RS06920	COG1309	transcriptional regulator
I6G64_RS06925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS06930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G64_RS06935	COG0254	rRNA binding
I6G64_RS06940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G64_RS06945	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G64_RS06950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G64_RS06955	COG1121	(ABC) transporter
I6G64_RS06980	COG3397	chitin binding
I6G64_RS07015	COG2165	general secretion pathway protein
I6G64_RS07035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G64_RS07070	COG3695	enzyme binding
I6G64_RS07075	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6G64_RS07080	COG1946	Acyl-CoA thioesterase
I6G64_RS07085	COG0004	ammonium transporteR
I6G64_RS07090	COG0347	Belongs to the P(II) protein family
I6G64_RS07095	COG1132	(ABC) transporter
I6G64_RS07100	COG1132	(ABC) transporter
I6G64_RS07105	COG1522	sequence-specific DNA binding
I6G64_RS07115	COG0561	phosphatase activity
I6G64_RS07120	COG4533	DNA binding
I6G64_RS07125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G64_RS07130	COG0824	Thioesterase
I6G64_RS07135	COG1555	photosystem II stabilization
I6G64_RS07140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G64_RS07150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G64_RS07155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G64_RS07165	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G64_RS07170	COG0271	Belongs to the BolA IbaG family
I6G64_RS07175	COG3056	Lipoprotein
I6G64_RS07180	COG2223	nitrite transmembrane transporter activity
I6G64_RS07185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G64_RS07190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G64_RS07195	COG1845	cytochrome c oxidase, subunit III
I6G64_RS07200	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G64_RS07205	COG0109	protoheme IX farnesyltransferase activity
I6G64_RS07210	COG2814	Major facilitator Superfamily
I6G64_RS07215	COG1666	GTP binding
I6G64_RS07220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G64_RS07225	COG0693	protein deglycase activity
I6G64_RS07230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G64_RS07230	COG0301	tRNA thio-modification
I6G64_RS07235	COG1722	exodeoxyribonuclease VII activity
I6G64_RS07240	COG0142	geranyltranstransferase activity
I6G64_RS07245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G64_RS07250	COG0667	Aldo Keto reductase
I6G64_RS07255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G64_RS07260	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G64_RS07265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G64_RS07270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G64_RS07275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G64_RS07275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G64_RS07280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G64_RS07290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G64_RS07300	COG1862	Preprotein translocase
I6G64_RS07305	COG0343	queuine tRNA-ribosyltransferase activity
I6G64_RS07310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G64_RS07315	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6G64_RS07320	COG0450	alkyl hydroperoxide reductase
I6G64_RS07330	COG0366	Alpha amylase catalytic
I6G64_RS07335	COG0668	transmembrane transport
I6G64_RS07350	COG3093	addiction module antidote protein HigA
I6G64_RS07365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G64_RS07375	COG5002	protein histidine kinase activity
I6G64_RS07380	COG0745	RESPONSE REGULATOR receiver
I6G64_RS07385	COG0420	3'-5' exonuclease activity
I6G64_RS07390	COG0419	ATPase involved in DNA repair
I6G64_RS07420	COG1940	carbohydrate kinase activity
I6G64_RS07435	COG0191	fructose-bisphosphate aldolase activity
I6G64_RS07450	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS07455	COG1129	ABC transporter
I6G64_RS07465	COG2974	May be involved in recombination
I6G64_RS07480	COG3123	guanosine phosphorylase activity
I6G64_RS07505	COG0667	Aldo Keto reductase
I6G64_RS07510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G64_RS07555	COG2226	methyltransferase
I6G64_RS07565	COG3416	Protein conserved in bacteria
I6G64_RS07600	COG1335	isochorismatase
I6G64_RS07615	COG0346	lactoylglutathione lyase activity
I6G64_RS07620	COG1349	DNA-binding transcription factor activity
I6G64_RS07645	COG3961	Belongs to the TPP enzyme family
I6G64_RS07650	COG0583	DNA-binding transcription factor activity
I6G64_RS07685	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS07690	COG2207	Transcriptional regulator
I6G64_RS07695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G64_RS07715	COG3391	amine dehydrogenase activity
I6G64_RS07720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G64_RS07725	COG1629	transport
I6G64_RS07725	COG4774	siderophore transport
I6G64_RS07730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G64_RS07735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G64_RS07735	COG2226	methyltransferase
I6G64_RS07735	COG3433	isochorismatase activity
I6G64_RS07745	COG0747	negative chemotaxis
I6G64_RS07750	COG3038	cytochrome b561
I6G64_RS07780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G64_RS07790	COG1073	alpha beta
I6G64_RS07795	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6G64_RS07800	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G64_RS07885	COG3188	usher protein
I6G64_RS07890	COG3121	Chaperone
I6G64_RS07940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G64_RS07945	COG0584	glycerophosphoryl diester phosphodiesterase
I6G64_RS07950	COG2991	Protein conserved in bacteria
I6G64_RS07955	COG1477	protein flavinylation
I6G64_RS07960	COG2871	sodium ion transport
I6G64_RS07965	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G64_RS07970	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G64_RS07975	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G64_RS07980	COG1805	sodium ion transport
I6G64_RS07985	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G64_RS07990	COG3034	peptidoglycan biosynthetic process
I6G64_RS07995	COG0121	glutamine amidotransferase
I6G64_RS08000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G64_RS08005	COG1960	acyl-CoA dehydrogenase activity
I6G64_RS08020	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I6G64_RS08025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6G64_RS08030	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6G64_RS08035	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6G64_RS08040	COG0235	Class ii aldolase
I6G64_RS08045	COG0436	Aminotransferase
I6G64_RS08055	COG2233	PERMEase
I6G64_RS08060	COG2351	hydroxyisourate hydrolase activity
I6G64_RS08075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G64_RS08080	COG1126	abc transporter atp-binding protein
I6G64_RS08085	COG0765	amino acid transport
I6G64_RS08185	COG1953	Uracil, thiamine, allantoin
I6G64_RS08195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G64_RS08200	COG0328	RNA-DNA hybrid ribonuclease activity
I6G64_RS08205	COG2226	methyltransferase
I6G64_RS08210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G64_RS08215	COG1388	LysM domain
I6G64_RS08215	COG0741	lytic transglycosylase activity
I6G64_RS08225	COG2814	Major facilitator Superfamily
I6G64_RS08230	COG0583	DNA-binding transcription factor activity
I6G64_RS08240	COG0656	L-ascorbic acid biosynthetic process
I6G64_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS08255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G64_RS08260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G64_RS08295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G64_RS08305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G64_RS08355	COG0542	response to heat
I6G64_RS08365	COG0564	pseudouridine synthase activity
I6G64_RS08370	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G64_RS08375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G64_RS08385	COG0077	Prephenate dehydratase
I6G64_RS08385	COG1605	Chorismate mutase
I6G64_RS08390	COG0287	Prephenate dehydrogenase
I6G64_RS08390	COG1605	Chorismate mutase
I6G64_RS08395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G64_RS08400	COG3137	Salt-induced outer membrane protein
I6G64_RS08515	COG0335	large ribosomal subunit rRNA binding
I6G64_RS08520	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G64_RS08525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G64_RS08530	COG0228	four-way junction DNA binding
I6G64_RS08535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G64_RS08540	COG4137	Cytochrome C assembly protein
I6G64_RS08545	COG4536	flavin adenine dinucleotide binding
I6G64_RS08550	COG1854	S-ribosylhomocysteine lyase activity
I6G64_RS08555	COG2918	glutathione biosynthetic process
I6G64_RS08560	COG1238	metal cluster binding
I6G64_RS08565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G64_RS08590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G64_RS08595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G64_RS08600	COG2137	regulation of response to DNA damage stimulus
I6G64_RS08605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G64_RS08625	COG1917	Cupin 2, conserved barrel domain protein
I6G64_RS08625	COG2169	Transcriptional regulator
I6G64_RS08630	COG2723	6-phospho-beta-galactosidase activity
I6G64_RS08635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G64_RS08640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G64_RS08645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G64_RS08650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G64_RS08655	COG4942	peptidase
I6G64_RS08655	COG1388	LysM domain
I6G64_RS08660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G64_RS08665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6G64_RS08670	COG0585	pseudouridine synthase activity
I6G64_RS08675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6G64_RS08680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G64_RS08685	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6G64_RS08695	COG0529	Catalyzes the synthesis of activated sulfate
I6G64_RS08700	COG2895	sulfate adenylyltransferase (ATP) activity
I6G64_RS08705	COG0175	sulfate reduction
I6G64_RS08710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G64_RS08710	COG1648	precorrin-2 dehydrogenase activity
I6G64_RS08715	COG2234	aminopeptidase activity
I6G64_RS08720	COG0175	sulfate reduction
I6G64_RS08725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G64_RS08730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G64_RS08735	COG0720	synthase
I6G64_RS08750	COG0602	queuosine metabolic process
I6G64_RS08755	COG2271	Major facilitator Superfamily
I6G64_RS08760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G64_RS08765	COG2986	histidine ammonia-lyase
I6G64_RS08795	COG0504	CTP synthase activity
I6G64_RS08800	COG3956	TIGRFAM MazG family protein
I6G64_RS08805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G64_RS08820	COG1929	Belongs to the glycerate kinase type-1 family
I6G64_RS08825	COG2084	Dehydrogenase
I6G64_RS08830	COG3836	Belongs to the HpcH HpaI aldolase family
I6G64_RS08835	COG4948	Mandelate Racemase Muconate Lactonizing
I6G64_RS08840	COG4948	Mandelate Racemase Muconate Lactonizing
I6G64_RS08845	COG2271	Major facilitator Superfamily
I6G64_RS08850	COG2721	sulfolactate sulfo-lyase activity
I6G64_RS08855	COG3835	regulator
I6G64_RS08860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G64_RS08865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6G64_RS08870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G64_RS08880	COG2860	membrane
I6G64_RS08885	COG0316	Belongs to the HesB IscA family
I6G64_RS08895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G64_RS08900	COG3725	Membrane protein required for beta-lactamase induction
I6G64_RS08905	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G64_RS08915	COG4969	Belongs to the N-Me-Phe pilin family
I6G64_RS08920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G64_RS08925	COG1459	type II secretion system
I6G64_RS08930	COG0516	GMP reductase activity
I6G64_RS08935	COG0237	dephospho-CoA kinase activity
I6G64_RS08940	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6G64_RS08945	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6G64_RS08950	COG0494	nUDIX hydrolase
I6G64_RS08955	COG0653	protein targeting
I6G64_RS08975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G64_RS08980	COG0849	cell division
I6G64_RS08985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G64_RS08990	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G64_RS08995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G64_RS09000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G64_RS09005	COG0772	Belongs to the SEDS family
I6G64_RS09015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G64_RS09020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G64_RS09025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G64_RS09030	COG0768	penicillin binding
I6G64_RS09035	COG3116	cell division
I6G64_RS09040	COG0275	rRNA processing
I6G64_RS09045	COG2001	Belongs to the MraZ family
I6G64_RS09065	COG0028	Belongs to the TPP enzyme family
I6G64_RS09070	COG1022	Amp-dependent synthetase and ligase
I6G64_RS09085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G64_RS09090	COG0473	3-isopropylmalate dehydrogenase activity
I6G64_RS09095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G64_RS09100	COG0066	3-isopropylmalate dehydratase activity
I6G64_RS09105	COG0471	metal ion transport
I6G64_RS09110	COG2814	Major facilitator Superfamily
I6G64_RS09125	COG4143	(ABC) transporter
I6G64_RS09130	COG1178	ABC-type Fe3 transport system permease component
I6G64_RS09145	COG0028	Belongs to the TPP enzyme family
I6G64_RS09150	COG0440	acetolactate synthase activity
I6G64_RS09155	COG0586	Pfam SNARE associated Golgi protein
I6G64_RS09160	COG0417	DNA replication proofreading
I6G64_RS09165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G64_RS09170	COG0564	pseudouridine synthase activity
I6G64_RS09180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G64_RS09190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G64_RS09195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G64_RS09200	COG2967	ApaG domain
I6G64_RS09205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G64_RS09215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G64_RS09225	COG2966	Psort location CytoplasmicMembrane, score
I6G64_RS09235	COG0475	glutathione-regulated potassium exporter activity
I6G64_RS09235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G64_RS09245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G64_RS09250	COG0505	Belongs to the CarA family
I6G64_RS09255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G64_RS09280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G64_RS09285	COG1047	Peptidyl-prolyl cis-trans
I6G64_RS09290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G64_RS09295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G64_RS09300	COG0196	riboflavin kinase activity
I6G64_RS09305	COG0268	Binds directly to 16S ribosomal RNA
I6G64_RS09310	COG0583	DNA-binding transcription factor activity
I6G64_RS09315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G64_RS09320	COG0484	heat shock protein binding
I6G64_RS09325	COG0443	Heat shock 70 kDa protein
I6G64_RS09330	COG1584	GPR1 FUN34 yaaH family protein
I6G64_RS09340	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G64_RS09345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G64_RS09350	COG1115	amino acid carrier protein
I6G64_RS09355	COG3022	response to hydroperoxide
I6G64_RS09365	COG0083	homoserine kinase activity
I6G64_RS09385	COG0745	RESPONSE REGULATOR receiver
I6G64_RS09390	COG3045	CreA protein
I6G64_RS09395	COG2207	Transcriptional regulator
I6G64_RS09395	COG3708	Transcriptional regulator
I6G64_RS09400	COG0406	alpha-ribazole phosphatase activity
I6G64_RS09405	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6G64_RS09410	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6G64_RS09415	COG0741	lytic transglycosylase activity
I6G64_RS09425	COG2199	diguanylate cyclase activity
I6G64_RS09430	COG2885	chlorophyll binding
I6G64_RS09435	COG0488	(ABC) transporter
I6G64_RS09445	COG0604	alcohol dehydrogenase
I6G64_RS09460	COG0560	Phosphoserine phosphatase
I6G64_RS09465	COG3726	membrane protein affecting hemolysin expression
I6G64_RS09475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G64_RS09480	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G64_RS09485	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G64_RS09490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G64_RS09495	COG0084	hydrolase, TatD family'
I6G64_RS09500	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G64_RS09505	COG3237	CsbD-like
I6G64_RS09510	COG5487	UPF0391 membrane protein
I6G64_RS09515	COG2823	Periplasmic or secreted lipoprotein
I6G64_RS09520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G64_RS09525	COG3550	peptidyl-serine autophosphorylation
I6G64_RS09540	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6G64_RS09545	COG2813	Specifically methylates the guanine in position
I6G64_RS09550	COG0667	Aldo Keto reductase
I6G64_RS09580	COG3706	GGDEF domain
I6G64_RS09585	COG1309	transcriptional regulator
I6G64_RS09600	COG2814	Major facilitator Superfamily
I6G64_RS09605	COG0738	Major facilitator superfamily
I6G64_RS09610	COG3254	rhamnose metabolic process
I6G64_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS09620	COG3618	amidohydrolase
I6G64_RS09625	COG4948	Mandelate Racemase Muconate Lactonizing
I6G64_RS09630	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G64_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS09645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G64_RS09650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G64_RS09655	COG2368	4-hydroxyphenylacetate
I6G64_RS09675	COG3971	2-oxopent-4-enoate hydratase activity
I6G64_RS09690	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS09705	COG1846	Transcriptional regulator
I6G64_RS09730	COG1113	amino acid transport
I6G64_RS09750	COG2267	carboxylic ester hydrolase activity
I6G64_RS09760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G64_RS09770	COG1454	alcohol dehydrogenase
I6G64_RS09805	COG0811	peptide transport
I6G64_RS09830	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G64_RS09835	COG1376	ErfK ybiS ycfS ynhG family protein
I6G64_RS09840	COG2207	Transcriptional regulator
I6G64_RS09840	COG3708	Transcriptional regulator
I6G64_RS09845	COG2207	Transcriptional regulator
I6G64_RS09860	COG3391	amine dehydrogenase activity
I6G64_RS09875	COG0174	glutamine synthetase
I6G64_RS09895	COG1966	Carbon starvation protein
I6G64_RS09900	COG2879	small protein
I6G64_RS09905	COG0523	cobalamin synthesis protein
I6G64_RS09910	COG1609	Transcriptional regulator
I6G64_RS09915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS09915	COG1263	PTS System
I6G64_RS09920	COG2723	6-phospho-beta-galactosidase activity
I6G64_RS09950	COG3550	peptidyl-serine autophosphorylation
I6G64_RS09955	COG1396	sequence-specific DNA binding
I6G64_RS10040	COG1192	Involved in chromosome partitioning
I6G64_RS10085	COG0795	lipopolysaccharide-transporting ATPase activity
I6G64_RS10090	COG0795	lipopolysaccharide-transporting ATPase activity
I6G64_RS10095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G64_RS10100	COG2927	DNA polymerase III (CHI subunit)
I6G64_RS10110	COG0456	acetyltransferase
I6G64_RS10120	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G64_RS10130	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6G64_RS10135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G64_RS10145	COG0540	Belongs to the ATCase OTCase family
I6G64_RS10160	COG2308	Evidence 4 Homologs of previously reported genes of
I6G64_RS10180	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6G64_RS10185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G64_RS10190	COG1609	Transcriptional regulator
I6G64_RS10215	COG1263	PTS System
I6G64_RS10215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS10220	COG0366	Alpha amylase catalytic
I6G64_RS10225	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G64_RS10230	COG0583	DNA-binding transcription factor activity
I6G64_RS10255	COG0701	Predicted permease
I6G64_RS10260	COG2188	Transcriptional regulator
I6G64_RS10265	COG3624	Phosphonate C-P lyase system protein PhnG
I6G64_RS10270	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6G64_RS10275	COG3626	phosphonate metabolism
I6G64_RS10280	COG3627	carbon phosphorus lyase activity
I6G64_RS10285	COG4107	phosphonate C-P lyase system protein PhnK
I6G64_RS10290	COG4778	phosphonate C-P lyase system protein PhnL
I6G64_RS10295	COG3454	Phosphonate metabolism
I6G64_RS10300	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6G64_RS10310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G64_RS10315	COG0702	epimerase
I6G64_RS10320	COG3787	Belongs to the UPF0306 family
I6G64_RS10340	COG2827	Endonuclease containing a URI domain
I6G64_RS10345	COG3153	acetyltransferase
I6G64_RS10350	COG3154	lipid carrier protein
I6G64_RS10355	COG0826	peptidase U32
I6G64_RS10360	COG0826	peptidase U32
I6G64_RS10400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS10405	COG0477	Major facilitator Superfamily
I6G64_RS10415	COG0425	Belongs to the sulfur carrier protein TusA family
I6G64_RS10420	COG2391	methyltransferase activity
I6G64_RS10425	COG0513	Belongs to the DEAD box helicase family
I6G64_RS10440	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G64_RS10445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G64_RS10450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G64_RS10455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G64_RS10460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G64_RS10465	COG0195	Participates in both transcription termination and antitermination
I6G64_RS10470	COG0779	Required for maturation of 30S ribosomal subunits
I6G64_RS10485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G64_RS10490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G64_RS10495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G64_RS10505	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6G64_RS10510	COG1534	Rna-binding protein
I6G64_RS10520	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G64_RS10525	COG0745	RESPONSE REGULATOR receiver
I6G64_RS10530	COG0642	Histidine kinase
I6G64_RS10540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G64_RS10545	COG0697	spore germination
I6G64_RS10550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G64_RS10555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G64_RS10560	COG0142	geranyltranstransferase activity
I6G64_RS10570	COG3423	Transcriptional regulator
I6G64_RS10575	COG0039	L-malate dehydrogenase activity
I6G64_RS10580	COG1438	arginine binding
I6G64_RS10595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G64_RS10600	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6G64_RS10605	COG0840	transmembrane signaling receptor activity
I6G64_RS10610	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G64_RS10615	COG2105	PFAM AIG2 family protein
I6G64_RS10620	COG2911	Protein conserved in bacteria
I6G64_RS10625	COG0729	surface antigen
I6G64_RS10630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G64_RS10635	COG1253	flavin adenine dinucleotide binding
I6G64_RS10645	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6G64_RS10650	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G64_RS10655	COG0737	Belongs to the 5'-nucleotidase family
I6G64_RS10660	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6G64_RS10665	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G64_RS10670	COG3061	Opacity-associated protein A
I6G64_RS10680	COG0359	binds to the 23S rRNA
I6G64_RS10685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G64_RS10695	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G64_RS10705	COG1073	alpha beta
I6G64_RS10710	COG3650	response to hydrogen peroxide
I6G64_RS10720	COG3766	membrane
I6G64_RS10725	COG1960	acyl-CoA dehydrogenase activity
I6G64_RS10730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G64_RS10735	COG0557	exoribonuclease II activity
I6G64_RS10740	COG1959	2 iron, 2 sulfur cluster binding
I6G64_RS10745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G64_RS10750	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6G64_RS10755	COG0330	HflC and HflK could
I6G64_RS10760	COG0330	HflC and HflK could
I6G64_RS10765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G64_RS10770	COG1923	regulation of RNA biosynthetic process
I6G64_RS10775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G64_RS10780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G64_RS10785	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G64_RS10790	COG0802	atpase or kinase
I6G64_RS10795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G64_RS10795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G64_RS10800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G64_RS10820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G64_RS10825	COG1162	GTPase activity
I6G64_RS10830	COG0688	phosphatidylethanolamine metabolic process
I6G64_RS10835	COG3264	Mechanosensitive ion channel
I6G64_RS10835	COG1511	domain protein
I6G64_RS10840	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6G64_RS10845	COG1053	succinate dehydrogenase
I6G64_RS10850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G64_RS10855	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6G64_RS10860	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6G64_RS10875	COG5510	response to toxic substance
I6G64_RS10880	COG5510	response to toxic substance
I6G64_RS10885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G64_RS10900	COG0459	protein refolding
I6G64_RS10905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G64_RS10920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G64_RS10930	COG4232	protein-disulfide reductase activity
I6G64_RS10935	COG1309	transcriptional regulator
I6G64_RS10945	COG0659	secondary active sulfate transmembrane transporter activity
I6G64_RS10950	COG0288	reversible hydration of carbon dioxide
I6G64_RS10960	COG1301	dicarboxylic acid transport
I6G64_RS10965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G64_RS10970	COG3162	membrane
I6G64_RS10975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G64_RS11005	COG0138	bifunctional purine biosynthesis protein purh
I6G64_RS11010	COG0151	Belongs to the GarS family
I6G64_RS11035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6G64_RS11040	COG2816	NAD+ diphosphatase activity
I6G64_RS11045	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6G64_RS11055	COG0352	thiamine-phosphate diphosphorylase activity
I6G64_RS11060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G64_RS11065	COG2104	thiamine diphosphate biosynthetic process
I6G64_RS11070	COG2022	thiamine diphosphate biosynthetic process
I6G64_RS11090	COG2205	protein histidine kinase activity
I6G64_RS11105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G64_RS11110	COG0085	RNA polymerase activity
I6G64_RS11115	COG0222	ribosome binding
I6G64_RS11120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G64_RS11125	COG0081	regulation of translation
I6G64_RS11130	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G64_RS11135	COG0250	Participates in transcription elongation, termination and antitermination
I6G64_RS11145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G64_RS11180	COG1072	(Pantothenic acid kinase))
I6G64_RS11185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6G64_RS11185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6G64_RS11190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G64_RS11220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G64_RS11225	COG1739	Uncharacterized protein family UPF0029
I6G64_RS11230	COG0006	proline dipeptidase activity
I6G64_RS11235	COG2271	Major facilitator Superfamily
I6G64_RS11240	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G64_RS11240	COG1024	Enoyl-CoA hydratase
I6G64_RS11245	COG0183	Belongs to the thiolase family
I6G64_RS11275	COG0084	hydrolase, TatD family'
I6G64_RS11280	COG0805	protein transport
I6G64_RS11290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G64_RS11295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G64_RS11300	COG3165	ubiquinone biosynthetic process from chorismate
I6G64_RS11305	COG2226	methyltransferase
I6G64_RS11310	COG1322	Protein conserved in bacteria
I6G64_RS11315	COG0586	Pfam SNARE associated Golgi protein
I6G64_RS11330	COG0412	Dienelactone hydrolase
I6G64_RS11335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G64_RS11340	COG0583	DNA-binding transcription factor activity
I6G64_RS11375	COG0584	glycerophosphoryl diester phosphodiesterase
I6G64_RS11380	COG3842	ATPase activity
I6G64_RS11390	COG1175	transmembrane transport
I6G64_RS11395	COG1653	transport
I6G64_RS11400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G64_RS11405	COG0410	ABC transporter
I6G64_RS11415	COG4177	L-phenylalanine transmembrane transporter activity
I6G64_RS11420	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS11430	COG0456	acetyltransferase
I6G64_RS11450	COG2177	Part of the ABC transporter FtsEX involved in
I6G64_RS11455	COG2884	Cell division ATP-binding protein ftsE
I6G64_RS11460	COG0552	protein localization to endoplasmic reticulum
I6G64_RS11465	COG0742	ribosomal rna small subunit methyltransferase
I6G64_RS11470	COG3776	membrane
I6G64_RS11480	COG3714	YhhN family
I6G64_RS11510	COG0425	Belongs to the sulfur carrier protein TusA family
I6G64_RS11515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G64_RS11530	COG0247	lactate metabolic process
I6G64_RS11540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G64_RS11550	COG0584	glycerophosphoryl diester phosphodiesterase
I6G64_RS11555	COG0561	phosphatase activity
I6G64_RS11560	COG2267	carboxylic ester hydrolase activity
I6G64_RS11565	COG1280	lysine exporter protein (LysE YggA)
I6G64_RS11570	COG1280	lysine exporter protein (LysE YggA)
I6G64_RS11580	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6G64_RS11585	COG2050	protein possibly involved in aromatic compounds catabolism
I6G64_RS11595	COG3180	Ammonia monooxygenase
I6G64_RS11610	COG0210	DNA helicase
I6G64_RS11615	COG1011	Hydrolase
I6G64_RS11625	COG3159	Protein conserved in bacteria
I6G64_RS11630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G64_RS11635	COG5567	small periplasmic lipoprotein
I6G64_RS11640	COG1965	Belongs to the frataxin family
I6G64_RS11645	COG3072	Adenylate cyclase
I6G64_RS11650	COG0181	hydroxymethylbilane synthase activity
I6G64_RS11660	COG2959	enzyme of heme biosynthesis
I6G64_RS11665	COG3071	HemY protein
I6G64_RS11695	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6G64_RS11705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G64_RS11710	COG2244	polysaccharide biosynthetic process
I6G64_RS11715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G64_RS11720	COG0456	acetyltransferase
I6G64_RS11725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G64_RS11730	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G64_RS11735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G64_RS11740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G64_RS11750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G64_RS11755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G64_RS11760	COG3118	belongs to the thioredoxin family
I6G64_RS11765	COG0513	Belongs to the DEAD box helicase family
I6G64_RS11770	COG0248	Ppx GppA phosphatase
I6G64_RS11780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G64_RS11785	COG0612	Peptidase, M16
I6G64_RS11790	COG1301	dicarboxylic acid transport
I6G64_RS11795	COG2200	EAL domain
I6G64_RS11795	COG2199	diguanylate cyclase activity
I6G64_RS11800	COG0457	Tetratricopeptide repeat
I6G64_RS11800	COG3118	belongs to the thioredoxin family
I6G64_RS11805	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6G64_RS11810	COG1215	transferase activity, transferring glycosyl groups
I6G64_RS11815	COG1215	transferase activity, transferring glycosyl groups
I6G64_RS11840	COG2194	sulfuric ester hydrolase activity
I6G64_RS11845	COG4608	Belongs to the ABC transporter superfamily
I6G64_RS11850	COG0444	Belongs to the ABC transporter superfamily
I6G64_RS11855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G64_RS11860	COG0601	transmembrane transport
I6G64_RS11865	COG0747	negative chemotaxis
I6G64_RS11905	COG2197	response regulator
I6G64_RS11910	COG2194	sulfuric ester hydrolase activity
I6G64_RS11915	COG1764	response to oxidative stress
I6G64_RS11920	COG1846	Transcriptional regulator
I6G64_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS11975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G64_RS11980	COG0583	DNA-binding transcription factor activity
I6G64_RS11985	COG2814	Major facilitator Superfamily
I6G64_RS12000	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS12030	COG5001	Diguanylate cyclase
I6G64_RS12030	COG5002	protein histidine kinase activity
I6G64_RS12030	COG3447	MASE1 domain protein
I6G64_RS12075	COG0582	viral genome integration into host DNA
I6G64_RS12095	COG2807	transmembrane transport
I6G64_RS12100	COG0583	DNA-binding transcription factor activity
I6G64_RS12115	COG2207	Transcriptional regulator
I6G64_RS12115	COG1609	Transcriptional regulator
I6G64_RS12120	COG4214	carbohydrate transport
I6G64_RS12125	COG1129	ABC transporter
I6G64_RS12130	COG4213	ABC transporter substrate-binding protein
I6G64_RS12135	COG2115	Belongs to the xylose isomerase family
I6G64_RS12140	COG1070	Carbohydrate kinase
I6G64_RS12155	COG0402	S-adenosylhomocysteine deaminase activity
I6G64_RS12160	COG1335	isochorismatase
I6G64_RS12170	COG3274	enterobacterial common antigen metabolic process
I6G64_RS12180	COG3276	selenocysteine insertion sequence binding
I6G64_RS12185	COG1921	L-seryl-tRNASec selenium transferase activity
I6G64_RS12190	COG0625	glutathione transferase activity
I6G64_RS12200	COG3058	Necessary for formate dehydrogenase activity
I6G64_RS12205	COG2864	formate dehydrogenase
I6G64_RS12210	COG0437	4 iron, 4 sulfur cluster binding
I6G64_RS12225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G64_RS12235	COG2258	MOSC domain
I6G64_RS12250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G64_RS12260	COG3722	fumarate hydratase activity
I6G64_RS12265	COG0246	Mannitol dehydrogenase
I6G64_RS12270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G64_RS12270	COG2213	PTS system mannitol-specific
I6G64_RS12285	COG0751	glycine-tRNA ligase activity
I6G64_RS12290	COG0752	glycyl-tRNA synthetase alpha subunit
I6G64_RS12295	COG2271	Major facilitator Superfamily
I6G64_RS12300	COG2771	luxR family
I6G64_RS12310	COG2818	Glycosylase
I6G64_RS12315	COG0456	acetyltransferase
I6G64_RS12320	COG2885	chlorophyll binding
I6G64_RS12325	COG1609	Transcriptional regulator
I6G64_RS12335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G64_RS12345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G64_RS12355	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G64_RS12360	COG0366	Alpha amylase catalytic
I6G64_RS12365	COG3977	Valine--pyruvate aminotransferase
I6G64_RS12370	COG2985	domain, Protein
I6G64_RS12375	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G64_RS12380	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G64_RS12385	COG5645	(Lipo)protein
I6G64_RS12390	COG0823	Involved in the tonB-independent uptake of proteins
I6G64_RS12395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G64_RS12400	COG2423	ornithine cyclodeaminase activity
I6G64_RS12405	COG0561	phosphatase activity
I6G64_RS12410	COG0187	DNA topoisomerase II activity
I6G64_RS12415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G64_RS12420	COG0592	DNA-directed DNA polymerase activity
I6G64_RS12425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G64_RS12435	COG0594	ribonuclease P activity
I6G64_RS12440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G64_RS12445	COG0706	membrane insertase activity
I6G64_RS12450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G64_RS12460	COG2091	lysine biosynthetic process via aminoadipic acid
I6G64_RS12465	COG0431	NADPH-dependent FMN reductase
I6G64_RS12475	COG2252	PERMEase
I6G64_RS12480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G64_RS12485	COG0765	amino acid transport
I6G64_RS12490	COG0765	amino acid transport
I6G64_RS12495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS12510	COG0581	inorganic phosphate transmembrane transporter activity
I6G64_RS12515	COG0573	inorganic phosphate transmembrane transporter activity
I6G64_RS12520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G64_RS12535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G64_RS12540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G64_RS12545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G64_RS12550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G64_RS12555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G64_RS12560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G64_RS12565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G64_RS12580	COG3312	ion transport
I6G64_RS12585	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G64_RS12590	COG0445	tRNA wobble uridine modification
I6G64_RS12595	COG0716	FMN binding
I6G64_RS12600	COG1522	sequence-specific DNA binding
I6G64_RS12605	COG2502	aspartate--ammonia ligase
I6G64_RS12610	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6G64_RS12615	COG0714	Associated with various cellular activities
I6G64_RS12620	COG3158	transport of potassium into the cell
I6G64_RS12625	COG1869	D-ribose catabolic process
I6G64_RS12630	COG1129	ABC transporter
I6G64_RS12635	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS12645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G64_RS12650	COG1609	Transcriptional regulator
I6G64_RS12655	COG0477	Major facilitator Superfamily
I6G64_RS12660	COG2186	Transcriptional regulator
I6G64_RS12685	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G64_RS12690	COG0746	molybdenum cofactor guanylyltransferase activity
I6G64_RS12695	COG3084	Protein conserved in bacteria
I6G64_RS12700	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G64_RS12705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G64_RS12710	COG0204	Acyl-transferase
I6G64_RS12715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G64_RS12715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G64_RS12720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G64_RS12725	COG3078	GTPase activator activity
I6G64_RS12745	COG3852	Histidine kinase
I6G64_RS12760	COG1011	Hydrolase
I6G64_RS12765	COG1295	ribonuclease BN
I6G64_RS12770	COG1490	D-aminoacyl-tRNA deacylase activity
I6G64_RS12775	COG0456	acetyltransferase
I6G64_RS12780	COG2982	Protein involved in outer membrane biogenesis
I6G64_RS12785	COG2233	PERMEase
I6G64_RS12790	COG0786	glutamate:sodium symporter activity
I6G64_RS12795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G64_RS12800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G64_RS12805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G64_RS12810	COG1758	RNA polymerase activity
I6G64_RS12815	COG0194	GDP metabolic process
I6G64_RS12820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G64_RS12830	COG0583	DNA-binding transcription factor activity
I6G64_RS12835	COG2860	membrane
I6G64_RS12845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G64_RS12855	COG1561	YicC-like family, N-terminal region
I6G64_RS12860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G64_RS12865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G64_RS12870	COG1309	transcriptional regulator
I6G64_RS12875	COG0756	dUTP diphosphatase activity
I6G64_RS12880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G64_RS12885	COG2003	Belongs to the UPF0758 family
I6G64_RS12890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G64_RS12905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G64_RS12920	COG1519	Transferase
I6G64_RS12930	COG0438	transferase activity, transferring glycosyl groups
I6G64_RS12935	COG0438	transferase activity, transferring glycosyl groups
I6G64_RS12940	COG0859	PFAM glycosyl transferase family 9
I6G64_RS12955	COG1442	glycosyl transferase family 8
I6G64_RS12955	COG1216	Glycosyl transferase, family 2
I6G64_RS12960	COG3307	-O-antigen
I6G64_RS12965	COG0438	transferase activity, transferring glycosyl groups
I6G64_RS12970	COG0859	PFAM glycosyl transferase family 9
I6G64_RS12975	COG0859	PFAM glycosyl transferase family 9
I6G64_RS12980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G64_RS12985	COG0156	8-amino-7-oxononanoate synthase activity
I6G64_RS12990	COG1063	alcohol dehydrogenase
I6G64_RS12995	COG2861	carbohydrate metabolic process
I6G64_RS13000	COG4942	peptidase
I6G64_RS13005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G64_RS13010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G64_RS13015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G64_RS13025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G64_RS13030	COG1045	serine acetyltransferase
I6G64_RS13045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G64_RS13050	COG2205	protein histidine kinase activity
I6G64_RS13055	COG0745	RESPONSE REGULATOR receiver
I6G64_RS13060	COG3678	ATP-independent chaperone mediated protein folding
I6G64_RS13065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G64_RS13070	COG0205	6-phosphofructokinase activity
I6G64_RS13075	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G64_RS13085	COG0149	triose-phosphate isomerase activity
I6G64_RS13095	COG3152	Membrane
I6G64_RS13110	COG2814	Major facilitator Superfamily
I6G64_RS13115	COG1494	fructose-1,6-bisphosphatase
I6G64_RS13125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G64_RS13130	COG3074	FtsZ-dependent cytokinesis
I6G64_RS13135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G64_RS13140	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G64_RS13145	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G64_RS13150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G64_RS13155	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G64_RS13160	COG1609	Transcriptional regulator
I6G64_RS13165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G64_RS13170	COG0254	rRNA binding
I6G64_RS13175	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6G64_RS13180	COG0626	cystathionine gamma-synthase activity
I6G64_RS13185	COG0460	homoserine dehydrogenase
I6G64_RS13185	COG0527	aspartate kinase activity
I6G64_RS13205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G64_RS13220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G64_RS13225	COG0137	argininosuccinate synthase activity
I6G64_RS13230	COG0165	Argininosuccinate lyase
I6G64_RS13235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G64_RS13240	COG0678	peroxiredoxin activity
I6G64_RS13240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G64_RS13250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G64_RS13265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G64_RS13270	COG4206	TonB-dependent receptor
I6G64_RS13275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G64_RS13315	COG1879	ABC-type sugar transport system periplasmic component
I6G64_RS13320	COG1129	ABC transporter
I6G64_RS13325	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS13330	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS13335	COG0583	DNA-binding transcription factor activity
I6G64_RS13340	COG3085	chromosome segregation
I6G64_RS13350	COG2814	Major facilitator Superfamily
I6G64_RS13365	COG3978	acetolactate synthase activity
I6G64_RS13370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G64_RS13375	COG0129	dihydroxy-acid dehydratase activity
I6G64_RS13380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G64_RS13390	COG0583	DNA-binding transcription factor activity
I6G64_RS13395	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G64_RS13400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G64_RS13405	COG1942	4-Oxalocrotonate Tautomerase
I6G64_RS13410	COG2200	EAL domain
I6G64_RS13415	COG2982	Protein involved in outer membrane biogenesis
I6G64_RS13420	COG2134	cdp-diacylglycerol pyrophosphatase
I6G64_RS13425	COG0477	Major facilitator Superfamily
I6G64_RS13430	COG1295	ribonuclease BN
I6G64_RS13435	COG1024	Enoyl-CoA hydratase
I6G64_RS13440	COG5001	Diguanylate cyclase
I6G64_RS13445	COG3678	ATP-independent chaperone mediated protein folding
I6G64_RS13450	COG5564	TIM-barrel signal transduction protein
I6G64_RS13455	COG5441	Belongs to the UPF0261 family
I6G64_RS13460	COG1309	transcriptional regulator
I6G64_RS13480	COG2205	protein histidine kinase activity
I6G64_RS13480	COG0784	Response regulator, receiver
I6G64_RS13500	COG2318	DinB family
I6G64_RS13505	COG2831	hemolysin activation secretion protein
I6G64_RS13510	COG3210	domain, Protein
I6G64_RS13540	COG3188	usher protein
I6G64_RS13545	COG3121	Chaperone
I6G64_RS13590	COG3210	domain, Protein
I6G64_RS13600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G64_RS13605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G64_RS13630	COG0339	signal peptide processing
I6G64_RS13635	COG0742	ribosomal rna small subunit methyltransferase
I6G64_RS13650	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS13655	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS13660	COG1129	ABC transporter
I6G64_RS13675	COG0589	response to stress
I6G64_RS13685	COG0306	phosphate transporter
I6G64_RS13690	COG2081	HI0933 family
I6G64_RS13725	COG2197	response regulator
I6G64_RS13745	COG3539	Fimbrial protein
I6G64_RS13755	COG3188	usher protein
I6G64_RS13785	COG4619	ABC transporter
I6G64_RS13790	COG0390	transport system, permease component
I6G64_RS13800	COG2814	Major facilitator Superfamily
I6G64_RS13800	COG0477	Major facilitator Superfamily
I6G64_RS13810	COG3718	enzyme involved in inositol metabolism
I6G64_RS13820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G64_RS13830	COG3962	Belongs to the TPP enzyme family
I6G64_RS13835	COG0673	inositol 2-dehydrogenase activity
I6G64_RS13840	COG1082	Xylose isomerase domain protein TIM barrel
I6G64_RS13845	COG1082	Xylose isomerase domain protein TIM barrel
I6G64_RS13850	COG3191	aminopeptidase activity
I6G64_RS13855	COG1247	-acetyltransferase
I6G64_RS13860	COG1741	Belongs to the pirin family
I6G64_RS13865	COG1609	Transcriptional regulator
I6G64_RS13870	COG2610	gluconate transmembrane transporter activity
I6G64_RS13875	COG3265	gluconokinase activity
I6G64_RS13880	COG2095	MarC family integral membrane protein
I6G64_RS13885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G64_RS13890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G64_RS13895	COG1523	belongs to the glycosyl hydrolase 13 family
I6G64_RS13900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G64_RS13905	COG0297	glycogen (starch) synthase activity
I6G64_RS13910	COG0058	SHG alpha-glucan phosphorylase activity
I6G64_RS13915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G64_RS13920	COG1349	DNA-binding transcription factor activity
I6G64_RS13925	COG0705	Rhomboid family
I6G64_RS13930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G64_RS13940	COG2731	YhcH YjgK YiaL family protein
I6G64_RS13945	COG2271	Major facilitator Superfamily
I6G64_RS13950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G64_RS13955	COG2909	trisaccharide binding
I6G64_RS13960	COG0058	SHG alpha-glucan phosphorylase activity
I6G64_RS13965	COG1640	4-alpha-glucanotransferase
I6G64_RS13970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G64_RS13970	COG0316	Belongs to the HesB IscA family
I6G64_RS13975	COG1040	competence protein
I6G64_RS13980	COG2267	carboxylic ester hydrolase activity
I6G64_RS14000	COG1918	ferrous iron import across plasma membrane
I6G64_RS14005	COG2183	response to ionizing radiation
I6G64_RS14010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G64_RS14040	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G64_RS14045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G64_RS14050	COG1011	Hydrolase
I6G64_RS14060	COG0494	nUDIX hydrolase
I6G64_RS14065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G64_RS14090	COG4796	Type ii and iii secretion system protein
I6G64_RS14095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G64_RS14100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G64_RS14120	COG0546	phosphoglycolate phosphatase activity
I6G64_RS14125	COG0180	Tryptophanyl-tRNA synthetase
I6G64_RS14130	COG1648	precorrin-2 dehydrogenase activity
I6G64_RS14130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G64_RS14145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G64_RS14150	COG0402	S-adenosylhomocysteine deaminase activity
I6G64_RS14155	COG0738	Major facilitator superfamily
I6G64_RS14160	COG1609	Transcriptional regulator
I6G64_RS14165	COG1486	melibiose metabolic process
I6G64_RS14170	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G64_RS14175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G64_RS14180	COG3275	phosphorelay sensor kinase activity
I6G64_RS14200	COG0433	COG0433 Predicted ATPase
I6G64_RS14215	COG1289	transmembrane transporter activity
I6G64_RS14220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G64_RS14225	COG1765	OsmC-like protein
I6G64_RS14230	COG3954	Phosphoribulokinase
I6G64_RS14235	COG3089	Belongs to the UPF0270 family
I6G64_RS14240	COG0429	hydrolase of the alpha beta-hydrolase fold
I6G64_RS14255	COG4521	taurine ABC transporter
I6G64_RS14265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G64_RS14270	COG2175	clavaminate synthase activity
I6G64_RS14275	COG0488	(ABC) transporter
I6G64_RS14280	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G64_RS14290	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G64_RS14295	COG1047	Peptidyl-prolyl cis-trans
I6G64_RS14305	COG2900	Belongs to the SlyX family
I6G64_RS14310	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G64_RS14315	COG2964	Protein conserved in bacteria
I6G64_RS14320	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G64_RS14325	COG2923	Belongs to the DsrF TusC family
I6G64_RS14330	COG2168	tRNA wobble position uridine thiolation
I6G64_RS14335	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G64_RS14340	COG0049	tRNA binding
I6G64_RS14345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G64_RS14350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G64_RS14365	COG0051	transcription antitermination factor activity, RNA binding
I6G64_RS14370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G64_RS14375	COG0088	Forms part of the polypeptide exit tunnel
I6G64_RS14380	COG0089	rRNA binding
I6G64_RS14390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G64_RS14400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G64_RS14405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G64_RS14410	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G64_RS14415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G64_RS14420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G64_RS14425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G64_RS14430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G64_RS14435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G64_RS14440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G64_RS14445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G64_RS14450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G64_RS14455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G64_RS14460	COG1841	ribosomal large subunit assembly
I6G64_RS14465	COG0200	Binds to the 23S rRNA
I6G64_RS14470	COG0201	protein transport
I6G64_RS14475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G64_RS14480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G64_RS14485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G64_RS14490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G64_RS14495	COG0202	RNA polymerase activity
I6G64_RS14500	COG0203	ribosomal protein L17
I6G64_RS14510	COG0789	Transcriptional regulator
I6G64_RS14515	COG3036	rescue of stalled ribosome
I6G64_RS14520	COG1970	mechanosensitive ion channel activity
I6G64_RS14525	COG0569	domain protein
I6G64_RS14530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G64_RS14530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G64_RS14535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G64_RS14540	COG0242	peptide deformylase activity
I6G64_RS14545	COG0758	DNA mediated transformation
I6G64_RS14550	COG2922	Belongs to the Smg family
I6G64_RS14555	COG0551	DNA topoisomerase type I activity
I6G64_RS14560	COG0009	L-threonylcarbamoyladenylate synthase
I6G64_RS14565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G64_RS14570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G64_RS14605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6G64_RS14610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G64_RS14615	COG2224	Isocitrate lyase
I6G64_RS14620	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6G64_RS14625	COG0800	Aldolase
I6G64_RS14630	COG0129	dihydroxy-acid dehydratase activity
I6G64_RS14635	COG2610	gluconate transmembrane transporter activity
I6G64_RS14640	COG3265	gluconokinase activity
I6G64_RS14645	COG1414	Transcriptional regulator
I6G64_RS14655	COG2188	Transcriptional regulator
I6G64_RS14670	COG4149	molybdate abc transporter
I6G64_RS14680	COG3842	ATPase activity
I6G64_RS14685	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G64_RS14705	COG0527	aspartate kinase activity
I6G64_RS14715	COG0166	Belongs to the GPI family
I6G64_RS14725	COG3223	Belongs to the PsiE family
I6G64_RS14730	COG3833	ABC-type maltose transport systems, permease component
I6G64_RS14735	COG1175	transmembrane transport
I6G64_RS14740	COG2182	Extracellular solute-binding protein
I6G64_RS14745	COG0366	Alpha amylase catalytic
I6G64_RS14755	COG4580	involved in the transport of maltose and maltodextrins
I6G64_RS14770	COG3161	chorismate lyase activity
I6G64_RS14775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G64_RS14780	COG2937	Belongs to the GPAT DAPAT family
I6G64_RS14785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G64_RS14790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G64_RS14795	COG0534	Mate efflux family protein
I6G64_RS14800	COG3237	CsbD-like
I6G64_RS14805	COG0735	belongs to the Fur family
I6G64_RS14815	COG1595	DNA-templated transcription, initiation
I6G64_RS14825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G64_RS14835	COG0604	alcohol dehydrogenase
I6G64_RS14855	COG1113	amino acid transport
I6G64_RS14860	COG1522	sequence-specific DNA binding
I6G64_RS14870	COG1448	Aminotransferase
I6G64_RS14880	COG2315	Protein conserved in bacteria
I6G64_RS14885	COG0110	maltose O-acetyltransferase activity
I6G64_RS14890	COG1064	alcohol dehydrogenase
I6G64_RS14895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G64_RS14900	COG0629	single-stranded DNA binding
I6G64_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS14910	COG0583	DNA-binding transcription factor activity
I6G64_RS14920	COG0625	glutathione transferase activity
I6G64_RS14930	COG2252	PERMEase
I6G64_RS14935	COG0025	NhaP-type Na H and K H
I6G64_RS14940	COG0583	DNA-binding transcription factor activity
I6G64_RS14945	COG1380	Effector of murein hydrolase LrgA
I6G64_RS14955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G64_RS14965	COG1560	Kdo2-lipid A biosynthetic process
I6G64_RS15010	COG2264	protein methyltransferase activity
I6G64_RS15015	COG4145	pantothenate transmembrane transporter activity
I6G64_RS15020	COG3924	membrane
I6G64_RS15025	COG0439	Biotin carboxylase
I6G64_RS15030	COG0511	ligase activity, forming carbon-carbon bonds
I6G64_RS15035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G64_RS15040	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6G64_RS15045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G64_RS15050	COG0604	alcohol dehydrogenase
I6G64_RS15055	COG2200	EAL domain
I6G64_RS15055	COG2199	diguanylate cyclase activity
I6G64_RS15060	COG1077	Cell shape determining protein MreB Mrl
I6G64_RS15065	COG1792	Involved in formation and maintenance of cell shape
I6G64_RS15070	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G64_RS15075	COG0424	maF-like protein
I6G64_RS15090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G64_RS15095	COG0312	modulator of DNA gyrase
I6G64_RS15160	COG0583	DNA-binding transcription factor activity
I6G64_RS15170	COG1566	PFAM secretion protein HlyD family protein
I6G64_RS15175	COG1289	transmembrane transporter activity
I6G64_RS15185	COG2732	(Barnase) inhibitor
I6G64_RS15190	COG3028	Belongs to the UPF0307 family
I6G64_RS15195	COG0312	modulator of DNA gyrase
I6G64_RS15200	COG3783	Cytochrome b(562)
I6G64_RS15205	COG2207	Transcriptional regulator
I6G64_RS15215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G64_RS15225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G64_RS15255	COG3964	amidohydrolase
I6G64_RS15270	COG2706	6-phosphogluconolactonase activity
I6G64_RS15275	COG3711	transcriptional antiterminator
I6G64_RS15275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G64_RS15280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G64_RS15285	COG1660	Displays ATPase and GTPase activities
I6G64_RS15300	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G64_RS15305	COG1137	ATPase activity
I6G64_RS15310	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G64_RS15315	COG3117	lipopolysaccharide transmembrane transporter activity
I6G64_RS15320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G64_RS15325	COG0517	IMP dehydrogenase activity
I6G64_RS15325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G64_RS15330	COG0530	calcium, potassium:sodium antiporter activity
I6G64_RS15335	COG1127	ABC transporter
I6G64_RS15340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G64_RS15345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G64_RS15350	COG2854	intermembrane phospholipid transfer
I6G64_RS15355	COG3113	response to antibiotic
I6G64_RS15360	COG5007	Belongs to the BolA IbaG family
I6G64_RS15365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G64_RS15370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G64_RS15375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G64_RS15380	COG3105	Protein conserved in bacteria
I6G64_RS15385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G64_RS15390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G64_RS15395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G64_RS15400	COG0625	glutathione transferase activity
I6G64_RS15405	COG2969	positive regulation of protein catabolic process
I6G64_RS15410	COG0493	'glutamate synthase
I6G64_RS15415	COG0069	glutamate synthase activity
I6G64_RS15415	COG0067	glutamate synthase
I6G64_RS15415	COG0070	glutamate synthase
I6G64_RS15420	COG1242	4 iron, 4 sulfur cluster binding
I6G64_RS15425	COG0784	Response regulator, receiver
I6G64_RS15425	COG2198	Histidine kinase
I6G64_RS15425	COG5002	protein histidine kinase activity
I6G64_RS15430	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G64_RS15440	COG2823	Periplasmic or secreted lipoprotein
I6G64_RS15445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G64_RS15450	COG0792	nuclease activity
I6G64_RS15455	COG3107	peptidoglycan biosynthetic process
I6G64_RS15460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G64_RS15470	COG1741	Belongs to the pirin family
I6G64_RS15475	COG0583	DNA-binding transcription factor activity
I6G64_RS15480	COG0435	Glutathione S-transferase
I6G64_RS15485	COG2259	Doxx family
I6G64_RS15495	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6G64_RS15500	COG4575	ribosome binding
I6G64_RS15510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G64_RS15515	COG0586	Pfam SNARE associated Golgi protein
I6G64_RS15530	COG2271	Major facilitator Superfamily
I6G64_RS15535	COG1904	glucuronate isomerase
I6G64_RS15540	COG2721	sulfolactate sulfo-lyase activity
I6G64_RS15550	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G64_RS15555	COG0861	Integral membrane protein TerC family
I6G64_RS15565	COG0673	inositol 2-dehydrogenase activity
I6G64_RS15570	COG1451	nucleotide metabolic process
I6G64_RS15575	COG2813	Specifically methylates the guanine in position
I6G64_RS15580	COG1902	pentaerythritol trinitrate reductase activity
I6G64_RS15580	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G64_RS15595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G64_RS15600	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS15610	COG0625	glutathione transferase activity
I6G64_RS15635	COG3663	DNA glycosylase
I6G64_RS15645	COG0358	DNA primase activity
I6G64_RS15650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G64_RS15655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G64_RS15670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G64_RS15675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G64_RS15680	COG1968	undecaprenyl-diphosphatase activity
I6G64_RS15685	COG0617	tRNA 3'-terminal CCA addition
I6G64_RS15690	COG4991	sh3 domain protein
I6G64_RS15695	COG3025	triphosphatase activity
I6G64_RS15700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G64_RS15705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G64_RS15705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G64_RS15710	COG0531	amino acid
I6G64_RS15715	COG2960	long-chain fatty acid transporting porin activity
I6G64_RS15720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G64_RS15735	COG3384	dioxygenase
I6G64_RS15740	COG0754	glutathionylspermidine amidase activity
I6G64_RS15745	COG5463	Belongs to the UPF0441 family
I6G64_RS15755	COG2376	Dihydroxyacetone kinase
I6G64_RS15760	COG1461	Dihydroxyacetone kinase
I6G64_RS15775	COG1538	Outer membrane efflux protein
I6G64_RS15780	COG0494	nUDIX hydrolase
I6G64_RS15785	COG3151	Protein conserved in bacteria
I6G64_RS15790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G64_RS15795	COG3150	esterase
I6G64_RS15805	COG0583	DNA-binding transcription factor activity
I6G64_RS15810	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6G64_RS15815	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G64_RS15820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G64_RS15825	COG0204	Acyl-transferase
I6G64_RS15830	COG2132	Multicopper oxidase
I6G64_RS15835	COG0583	DNA-binding transcription factor activity
I6G64_RS15840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6G64_RS15845	COG2211	Major facilitator Superfamily
I6G64_RS15860	COG0741	lytic transglycosylase activity
I6G64_RS15870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G64_RS15875	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G64_RS15880	COG2723	6-phospho-beta-galactosidase activity
I6G64_RS15885	COG0656	L-ascorbic acid biosynthetic process
I6G64_RS15890	COG1979	alcohol dehydrogenase
I6G64_RS15895	COG2207	Transcriptional regulator
I6G64_RS15905	COG0583	DNA-binding transcription factor activity
I6G64_RS15910	COG0586	Pfam SNARE associated Golgi protein
I6G64_RS15925	COG0848	biopolymer transport protein
I6G64_RS15930	COG3609	addiction module antidote protein, CC2985 family
I6G64_RS15940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G64_RS15970	COG2831	hemolysin activation secretion protein
I6G64_RS16000	COG0477	Major facilitator Superfamily
I6G64_RS16020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G64_RS16020	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G64_RS16050	COG0454	-acetyltransferase
I6G64_RS16055	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6G64_RS16060	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G64_RS16065	COG3383	formate dehydrogenase (NAD+) activity
I6G64_RS16070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G64_RS16075	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G64_RS16085	COG3260	NADH ubiquinone oxidoreductase 20
I6G64_RS16090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G64_RS16095	COG3261	NADH dehydrogenase
I6G64_RS16095	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6G64_RS16100	COG0650	Formate hydrogenlyase subunit 4
I6G64_RS16105	COG0651	ATP synthesis coupled electron transport
I6G64_RS16110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G64_RS16120	COG0375	protein maturation
I6G64_RS16125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G64_RS16130	COG0298	carbon dioxide binding
I6G64_RS16135	COG0409	Hydrogenase expression formation protein
I6G64_RS16140	COG0309	Hydrogenase expression formation protein (HypE)
I6G64_RS16155	COG0583	DNA-binding transcription factor activity
I6G64_RS16160	COG0129	dihydroxy-acid dehydratase activity
I6G64_RS16165	COG0626	cystathionine gamma-synthase activity
I6G64_RS16175	COG3135	benzoate transporter
I6G64_RS16180	COG4948	Mandelate Racemase Muconate Lactonizing
I6G64_RS16185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G64_RS16190	COG0625	glutathione transferase activity
I6G64_RS16230	COG0076	glutamate decarboxylase activity
I6G64_RS16245	COG1566	PFAM secretion protein HlyD family protein
I6G64_RS16250	COG1136	(ABC) transporter
I6G64_RS16270	COG0300	oxidoreductase activity
I6G64_RS16270	COG3321	synthase
I6G64_RS16270	COG4221	oxidoreductase activity
I6G64_RS16270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G64_RS16275	COG2070	2-Nitropropane dioxygenase
I6G64_RS16275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G64_RS16280	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS16285	COG3320	Male sterility
I6G64_RS16285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G64_RS16290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G64_RS16315	COG1131	(ABC) transporter
I6G64_RS16325	COG1506	peptidase
I6G64_RS16325	COG0823	Involved in the tonB-independent uptake of proteins
I6G64_RS16375	COG1982	Orn Lys Arg decarboxylase major
I6G64_RS16380	COG0741	lytic transglycosylase activity
I6G64_RS16385	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6G64_RS16390	COG1194	a g-specific adenine glycosylase
I6G64_RS16395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G64_RS16400	COG3171	Protein conserved in bacteria
I6G64_RS16405	COG2066	Belongs to the glutaminase family
I6G64_RS16420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G64_RS16425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G64_RS16430	COG1872	DUF167
I6G64_RS16435	COG0762	integral membrane protein
I6G64_RS16440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G64_RS16445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G64_RS16450	COG2805	Type II/IV secretion system protein
I6G64_RS16455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G64_RS16460	COG1678	Uncharacterized ACR, COG1678
I6G64_RS16465	COG0189	ligase activity
I6G64_RS16470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G64_RS16475	COG2356	endonuclease I
I6G64_RS16480	COG3091	SprT-like family
I6G64_RS16485	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G64_RS16485	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G64_RS16490	COG2207	Transcriptional regulator
I6G64_RS16490	COG3708	Transcriptional regulator
I6G64_RS16495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G64_RS16505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G64_RS16515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G64_RS16515	COG2010	Cytochrome c
I6G64_RS16520	COG3940	Belongs to the glycosyl hydrolase 43 family
I6G64_RS16525	COG2211	Major facilitator Superfamily
I6G64_RS16530	COG1113	amino acid transport
I6G64_RS16535	COG2186	Transcriptional regulator
I6G64_RS16540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G64_RS16545	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G64_RS16550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G64_RS16560	COG3112	Uncharacterised protein family (UPF0231)
I6G64_RS16565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6G64_RS16570	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G64_RS16580	COG2132	Multicopper oxidase
I6G64_RS16590	COG0288	reversible hydration of carbon dioxide
I6G64_RS16595	COG1131	(ABC) transporter
I6G64_RS16600	COG0842	Transport permease protein
I6G64_RS16605	COG0726	polysaccharide deacetylase
I6G64_RS16610	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6G64_RS16615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G64_RS16620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G64_RS16625	COG0745	RESPONSE REGULATOR receiver
I6G64_RS16630	COG0642	Histidine kinase
I6G64_RS16635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G64_RS16645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G64_RS16655	COG1489	DNA binding
I6G64_RS16660	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G64_RS16665	COG1643	Atp-dependent helicase
I6G64_RS16670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G64_RS16675	COG4774	siderophore transport
I6G64_RS16680	COG1120	ATPase activity
I6G64_RS16685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G64_RS16690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G64_RS16700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G64_RS16710	COG1166	arginine decarboxylase activity
I6G64_RS16715	COG0010	Belongs to the arginase family
I6G64_RS16720	COG1187	pseudouridine synthase activity
I6G64_RS16725	COG2146	nitrite reductase [NAD(P)H] activity
I6G64_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS16745	COG1414	Transcriptional regulator
I6G64_RS16760	COG2271	Major facilitator Superfamily
I6G64_RS16775	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS16780	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6G64_RS16795	COG0501	Belongs to the peptidase M48B family
I6G64_RS16800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G64_RS16810	COG1175	transmembrane transport
I6G64_RS16815	COG3842	ATPase activity
I6G64_RS16820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G64_RS16825	COG0126	phosphoglycerate kinase activity
I6G64_RS16830	COG0191	fructose-bisphosphate aldolase activity
I6G64_RS16835	COG3385	transposase activity
I6G64_RS16850	COG3122	Protein conserved in bacteria
I6G64_RS16860	COG0235	Class ii aldolase
I6G64_RS16865	COG3623	hexulose-6-phosphate isomerase
I6G64_RS16870	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6G64_RS16875	COG1070	Carbohydrate kinase
I6G64_RS16885	COG2731	YhcH YjgK YiaL family protein
I6G64_RS16905	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS16910	COG1129	ABC transporter
I6G64_RS16915	COG1414	Transcriptional regulator
I6G64_RS16920	COG1279	arginine transmembrane transporter activity
I6G64_RS16930	COG0583	DNA-binding transcription factor activity
I6G64_RS16935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G64_RS16945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G64_RS16950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G64_RS16960	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6G64_RS16965	COG3079	Belongs to the UPF0149 family
I6G64_RS16970	COG0006	proline dipeptidase activity
I6G64_RS16975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G64_RS16980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G64_RS16995	COG1509	lysine 2,3-aminomutase activity
I6G64_RS17000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G64_RS17005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G64_RS17010	COG0509	glycine decarboxylation via glycine cleavage system
I6G64_RS17015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G64_RS17015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G64_RS17035	COG3713	MltA-interacting MipA family protein
I6G64_RS17040	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS17085	COG1272	protein, Hemolysin III
I6G64_RS17095	COG0354	folic acid binding
I6G64_RS17100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G64_RS17110	COG0745	RESPONSE REGULATOR receiver
I6G64_RS17115	COG2205	protein histidine kinase activity
I6G64_RS17120	COG4452	Inner membrane protein CreD
I6G64_RS17125	COG0716	FMN binding
I6G64_RS17130	COG4974	Belongs to the 'phage' integrase family
I6G64_RS17135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G64_RS17140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G64_RS17150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G64_RS17165	COG1278	Cold shock
I6G64_RS17175	COG0484	heat shock protein binding
I6G64_RS17180	COG3247	response to pH
I6G64_RS17185	COG4942	peptidase
I6G64_RS17205	COG5265	(ABC) transporter
I6G64_RS17210	COG1942	4-Oxalocrotonate Tautomerase
I6G64_RS17220	COG1309	transcriptional regulator
I6G64_RS17225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G64_RS17255	COG0583	DNA-binding transcription factor activity
I6G64_RS17260	COG1304	FMN binding
I6G64_RS17265	COG0583	DNA-binding transcription factor activity
I6G64_RS17290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS17300	COG1538	Outer membrane efflux protein
I6G64_RS17305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G64_RS17310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G64_RS17315	COG0582	viral genome integration into host DNA
I6G64_RS17320	COG3539	Fimbrial protein
I6G64_RS17325	COG3121	Chaperone
I6G64_RS17340	COG3539	Fimbrial protein
I6G64_RS17345	COG2197	response regulator
I6G64_RS17350	COG2197	response regulator
I6G64_RS17355	COG0582	viral genome integration into host DNA
I6G64_RS17360	COG4615	Cyclic peptide transporter
I6G64_RS17375	COG2807	transmembrane transport
I6G64_RS17380	COG4178	(ABC) transporter
I6G64_RS17400	COG0583	DNA-binding transcription factor activity
I6G64_RS17405	COG2814	Major facilitator Superfamily
I6G64_RS17410	COG0583	DNA-binding transcription factor activity
I6G64_RS17430	COG1609	Transcriptional regulator
I6G64_RS17440	COG1609	Transcriptional regulator
I6G64_RS17450	COG0204	Acyl-transferase
I6G64_RS17450	COG0318	PFAM AMP-dependent synthetase and ligase
I6G64_RS17455	COG0477	Major facilitator Superfamily
I6G64_RS17460	COG0667	Aldo Keto reductase
I6G64_RS17470	COG0861	Integral membrane protein TerC family
I6G64_RS17475	COG3066	DNA modification
I6G64_RS17480	COG0494	nUDIX hydrolase
I6G64_RS17490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G64_RS17495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G64_RS17515	COG4967	type IV pilus modification protein PilV
I6G64_RS17520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G64_RS17525	COG1025	Belongs to the peptidase M16 family
I6G64_RS17530	COG1074	ATP-dependent DNA helicase activity
I6G64_RS17535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G64_RS17540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G64_RS17540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G64_RS17545	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G64_RS17565	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6G64_RS17570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G64_RS17575	COG2166	iron-sulfur cluster assembly
I6G64_RS17580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G64_RS17590	COG0583	DNA-binding transcription factor activity
I6G64_RS17595	COG2363	Small membrane protein
I6G64_RS17600	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6G64_RS17605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G64_RS17610	COG1611	Belongs to the LOG family
I6G64_RS17630	COG2814	Major facilitator Superfamily
I6G64_RS17635	COG3098	single-species biofilm formation
I6G64_RS17640	COG0564	pseudouridine synthase activity
I6G64_RS17660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G64_RS17670	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G64_RS17675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G64_RS17680	COG0528	UMP kinase activity
I6G64_RS17685	COG0233	cytoplasmic translational termination
I6G64_RS17690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G64_RS17695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G64_RS17700	COG0575	Belongs to the CDS family
I6G64_RS17705	COG0750	zinc metalloprotease
I6G64_RS17710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G64_RS17715	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6G64_RS17720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G64_RS17725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G64_RS17730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G64_RS17735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G64_RS17740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G64_RS17750	COG0825	malonyl-CoA metabolic process
I6G64_RS17755	COG1982	Orn Lys Arg decarboxylase major
I6G64_RS17760	COG0346	lactoylglutathione lyase activity
I6G64_RS17765	COG0037	tRNA processing
I6G64_RS17775	COG4568	rho-dependent transcription termination
I6G64_RS17790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G64_RS17795	COG3015	lipoprotein NlpE involved in copper resistance
I6G64_RS17800	COG0442	prolyl-tRNA aminoacylation
I6G64_RS17805	COG1720	tRNA m6t6A37 methyltransferase activity
I6G64_RS17820	COG2011	ABC-type metal ion transport system permease component
I6G64_RS17830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G64_RS17860	COG0477	Major facilitator Superfamily
I6G64_RS17865	COG5544	Lipoprotein
I6G64_RS17870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G64_RS17875	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G64_RS17875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G64_RS17875	COG1042	CoA-binding domain protein
I6G64_RS17880	COG3148	PFAM DTW domain containing protein
I6G64_RS17885	COG3118	belongs to the thioredoxin family
I6G64_RS17890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G64_RS17895	COG2814	Major facilitator Superfamily
I6G64_RS17900	COG1566	PFAM secretion protein HlyD family protein
I6G64_RS17910	COG1846	Transcriptional regulator
I6G64_RS17920	COG2814	Major facilitator Superfamily
I6G64_RS17925	COG0583	DNA-binding transcription factor activity
I6G64_RS17930	COG2113	Glycine betaine
I6G64_RS17935	COG4176	ABC-type proline glycine betaine transport system permease component
I6G64_RS17955	COG3493	citrate carrier protein
I6G64_RS17965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G64_RS17975	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS18005	COG1780	Probably involved in ribonucleotide reductase function
I6G64_RS18010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G64_RS18015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G64_RS18025	COG4575	ribosome binding
I6G64_RS18040	COG0477	Major facilitator Superfamily
I6G64_RS18045	COG0583	DNA-binding transcription factor activity
I6G64_RS18070	COG0477	Major facilitator Superfamily
I6G64_RS18090	COG2259	Doxx family
I6G64_RS18095	COG2388	GCN5-related N-acetyl-transferase
I6G64_RS18105	COG2226	methyltransferase
I6G64_RS18115	COG0667	Aldo Keto reductase
I6G64_RS18120	COG0583	DNA-binding transcription factor activity
I6G64_RS18165	COG0667	Aldo Keto reductase
I6G64_RS18235	COG0582	viral genome integration into host DNA
I6G64_RS18245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G64_RS18250	COG2867	negative regulation of translational initiation
I6G64_RS18255	COG2914	Belongs to the UPF0125 (RnfH) family
I6G64_RS18260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G64_RS18265	COG0497	DNA recombination
I6G64_RS18270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G64_RS18275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G64_RS18280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G64_RS18285	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I6G64_RS18300	COG0513	Belongs to the DEAD box helicase family
I6G64_RS18305	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G64_RS18310	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G64_RS18330	COG3086	response to oxidative stress
I6G64_RS18340	COG0481	GTPase activity
I6G64_RS18345	COG0681	Belongs to the peptidase S26 family
I6G64_RS18350	COG0571	ribonuclease III activity
I6G64_RS18355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G64_RS18360	COG1381	Involved in DNA repair and RecF pathway recombination
I6G64_RS18365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G64_RS18370	COG0736	holo-[acyl-carrier-protein] synthase activity
I6G64_RS18375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G64_RS18380	COG1737	Transcriptional regulator
I6G64_RS18385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G64_RS18390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS18390	COG1263	PTS System
I6G64_RS18395	COG0560	Phosphoserine phosphatase
I6G64_RS18410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G64_RS18420	COG2205	protein histidine kinase activity
I6G64_RS18425	COG3170	Tfp pilus assembly protein FimV
I6G64_RS18430	COG2204	response regulator
I6G64_RS18435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G64_RS18435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G64_RS18440	COG0347	Belongs to the P(II) protein family
I6G64_RS18455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G64_RS18460	COG3842	ATPase activity
I6G64_RS18465	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G64_RS18470	COG1177	transmembrane transport
I6G64_RS18475	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS18480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G64_RS18490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G64_RS18490	COG1017	nitric oxide dioxygenase activity
I6G64_RS18495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G64_RS18500	COG2814	Major facilitator Superfamily
I6G64_RS18505	COG3711	transcriptional antiterminator
I6G64_RS18510	COG3683	transport system, periplasmic component
I6G64_RS18515	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6G64_RS18530	COG1959	2 iron, 2 sulfur cluster binding
I6G64_RS18535	COG1104	cysteine desulfurase activity
I6G64_RS18540	COG0822	iron-sulfur transferase activity
I6G64_RS18545	COG0316	Belongs to the HesB IscA family
I6G64_RS18550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G64_RS18555	COG0443	Heat shock 70 kDa protein
I6G64_RS18560	COG0633	Ferredoxin
I6G64_RS18565	COG2975	iron-sulfur cluster assembly
I6G64_RS18570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G64_RS18580	COG1737	Transcriptional regulator
I6G64_RS18585	COG1486	melibiose metabolic process
I6G64_RS18595	COG2373	Large extracellular alpha-helical protein
I6G64_RS18600	COG4953	penicillin-binding protein 1C
I6G64_RS18605	COG0105	UTP biosynthetic process
I6G64_RS18610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G64_RS18620	COG1426	Protein conserved in bacteria
I6G64_RS18625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G64_RS18630	COG0124	histidyl-tRNA synthetase
I6G64_RS18635	COG2976	Protein conserved in bacteria
I6G64_RS18640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G64_RS18645	COG1160	GTP binding
I6G64_RS18655	COG1645	bacterial-type flagellum-dependent swarming motility
I6G64_RS18670	COG1609	Transcriptional regulator
I6G64_RS18675	COG2271	Major facilitator Superfamily
I6G64_RS18685	COG1570	exodeoxyribonuclease VII activity
I6G64_RS18690	COG0516	GMP reductase activity
I6G64_RS18690	COG0517	IMP dehydrogenase activity
I6G64_RS18695	COG0519	Catalyzes the synthesis of GMP from XMP
I6G64_RS18695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G64_RS18700	COG0697	spore germination
I6G64_RS18705	COG0583	DNA-binding transcription factor activity
I6G64_RS18710	COG1733	regulation of RNA biosynthetic process
I6G64_RS18720	COG2205	protein histidine kinase activity
I6G64_RS18720	COG2198	Histidine kinase
I6G64_RS18720	COG0784	Response regulator, receiver
I6G64_RS18725	COG2197	response regulator
I6G64_RS18760	COG2814	Major facilitator Superfamily
I6G64_RS18780	COG0456	acetyltransferase
I6G64_RS18785	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G64_RS18790	COG0351	phosphomethylpyrimidine kinase
I6G64_RS18805	COG1349	DNA-binding transcription factor activity
I6G64_RS18810	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G64_RS18815	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS18830	COG3730	PTS system glucitol sorbitol-specific
I6G64_RS18835	COG1830	Aldolase
I6G64_RS18840	COG1802	Transcriptional regulator
I6G64_RS18845	COG0246	Mannitol dehydrogenase
I6G64_RS18850	COG2271	Major facilitator Superfamily
I6G64_RS18855	COG1063	alcohol dehydrogenase
I6G64_RS18860	COG4948	Mandelate Racemase Muconate Lactonizing
I6G64_RS18865	COG1597	lipid kinase activity
I6G64_RS18870	COG0826	peptidase U32
I6G64_RS18875	COG3422	double-strand break repair
I6G64_RS18890	COG0745	RESPONSE REGULATOR receiver
I6G64_RS18895	COG2205	protein histidine kinase activity
I6G64_RS18900	COG2814	Major facilitator Superfamily
I6G64_RS18905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G64_RS18910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G64_RS18915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS18920	COG0667	Aldo Keto reductase
I6G64_RS18930	COG2046	Belongs to the sulfate adenylyltransferase family
I6G64_RS18930	COG0529	Catalyzes the synthesis of activated sulfate
I6G64_RS18940	COG0443	Heat shock 70 kDa protein
I6G64_RS18945	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G64_RS18955	COG5001	Diguanylate cyclase
I6G64_RS18955	COG5002	protein histidine kinase activity
I6G64_RS18955	COG3447	MASE1 domain protein
I6G64_RS18960	COG2239	Acts as a magnesium transporter
I6G64_RS18975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G64_RS18980	COG0573	inorganic phosphate transmembrane transporter activity
I6G64_RS18985	COG0573	inorganic phosphate transmembrane transporter activity
I6G64_RS19000	COG3210	domain, Protein
I6G64_RS19020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G64_RS19035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G64_RS19040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G64_RS19045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G64_RS19050	COG2233	PERMEase
I6G64_RS19055	COG2261	transglycosylase associated protein
I6G64_RS19065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G64_RS19075	COG1393	Belongs to the ArsC family
I6G64_RS19080	COG4783	chaperone-mediated protein folding
I6G64_RS19110	COG0243	molybdopterin cofactor binding
I6G64_RS19115	COG0542	response to heat
I6G64_RS19120	COG2837	iron assimilation
I6G64_RS19125	COG1271	oxidase subunit
I6G64_RS19130	COG1294	oxidase, subunit
I6G64_RS19145	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G64_RS19150	COG0314	molybdopterin synthase activity
I6G64_RS19155	COG3781	membrane
I6G64_RS19160	COG0628	permease
I6G64_RS19165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G64_RS19170	COG2716	regulation of RNA biosynthetic process
I6G64_RS19175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G64_RS19180	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G64_RS19185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G64_RS19190	COG2321	neutral zinc metallopeptidase
I6G64_RS19200	COG0400	carboxylic ester hydrolase activity
I6G64_RS19225	COG1876	peptidase activity
I6G64_RS19230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G64_RS19235	COG1393	Belongs to the ArsC family
I6G64_RS19250	COG0456	acetyltransferase
I6G64_RS19270	COG4771	TonB-dependent receptor
I6G64_RS19280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G64_RS19290	COG2197	response regulator
I6G64_RS19295	COG3850	Histidine kinase
I6G64_RS19300	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G64_RS19300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G64_RS19305	COG3062	negative regulation of establishment of protein localization
I6G64_RS19310	COG0243	molybdopterin cofactor binding
I6G64_RS19315	COG3043	anaerobic respiration
I6G64_RS19320	COG3005	denitrification pathway
I6G64_RS19325	COG0494	nUDIX hydrolase
I6G64_RS19335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G64_RS19340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G64_RS19345	COG3397	chitin binding
I6G64_RS19350	COG0583	DNA-binding transcription factor activity
I6G64_RS19385	COG2040	homocysteine
I6G64_RS19390	COG0833	amino acid
I6G64_RS19400	COG1671	Belongs to the UPF0178 family
I6G64_RS19405	COG0408	coproporphyrinogen oxidase activity
I6G64_RS19415	COG0456	acetyltransferase
I6G64_RS19420	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G64_RS19435	COG2837	iron assimilation
I6G64_RS19440	COG4150	thiosulfate binding
I6G64_RS19445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G64_RS19450	COG4208	sulfate ABC transporter
I6G64_RS19460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G64_RS19470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS19475	COG0745	RESPONSE REGULATOR receiver
I6G64_RS19480	COG2205	protein histidine kinase activity
I6G64_RS19495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G64_RS19500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G64_RS19510	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6G64_RS19515	COG3115	cell septum assembly
I6G64_RS19520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G64_RS19525	COG3530	Putative quorum-sensing-regulated virulence factor
I6G64_RS19530	COG0385	Bile acid
I6G64_RS19535	COG0583	DNA-binding transcription factor activity
I6G64_RS19550	COG4303	Ethanolamine ammonia lyase large subunit
I6G64_RS19555	COG4302	ethanolamine ammonia-lyase activity
I6G64_RS19570	COG0675	Transposase, IS605 OrfB family
I6G64_RS19580	COG4771	TonB-dependent receptor
I6G64_RS19585	COG2382	esterase
I6G64_RS19590	COG3251	PFAM MbtH domain protein
I6G64_RS19595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6G64_RS19595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G64_RS19600	COG1120	ATPase activity
I6G64_RS19605	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G64_RS19610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G64_RS19620	COG4592	Periplasmic binding protein
I6G64_RS19625	COG1169	isochorismate synthase
I6G64_RS19630	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G64_RS19635	COG1535	isochorismatase
I6G64_RS19635	COG3433	isochorismatase activity
I6G64_RS19640	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS19665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G64_RS19680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G64_RS19685	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G64_RS19695	COG0667	Aldo Keto reductase
I6G64_RS19700	COG3961	Belongs to the TPP enzyme family
I6G64_RS19715	COG1794	racemase activity, acting on amino acids and derivatives
I6G64_RS19730	COG2223	nitrite transmembrane transporter activity
I6G64_RS19740	COG3279	Response regulator of the LytR AlgR family
I6G64_RS19745	COG3275	phosphorelay sensor kinase activity
I6G64_RS19760	COG0436	Aminotransferase
I6G64_RS19765	COG3038	cytochrome b561
I6G64_RS19780	COG1598	PFAM Uncharacterised protein family UPF0150
I6G64_RS19790	COG2951	lytic endotransglycosylase activity
I6G64_RS19805	COG0697	spore germination
I6G64_RS19815	COG0583	DNA-binding transcription factor activity
I6G64_RS19870	COG2116	formate transmembrane transporter activity
I6G64_RS19880	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G64_RS19885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G64_RS19890	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G64_RS19895	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6G64_RS19900	COG1138	Cytochrome C-type biogenesis protein
I6G64_RS19905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G64_RS19910	COG3088	subunit of a heme lyase
I6G64_RS19910	COG4235	cytochrome complex assembly
I6G64_RS19915	COG4235	cytochrome complex assembly
I6G64_RS19915	COG3088	subunit of a heme lyase
I6G64_RS19925	COG2067	long-chain fatty acid transport protein
I6G64_RS19930	COG3691	Protein conserved in bacteria
I6G64_RS19935	COG0183	Belongs to the thiolase family
I6G64_RS19940	COG1024	Enoyl-CoA hydratase
I6G64_RS19940	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G64_RS19945	COG2062	phosphohistidine phosphatase, SixA
I6G64_RS19950	COG2840	Smr protein MutS2
I6G64_RS19955	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G64_RS19960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G64_RS19965	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6G64_RS19970	COG0730	response to heat
I6G64_RS19975	COG3101	peptidyl-lysine hydroxylation
I6G64_RS19985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6G64_RS19985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G64_RS19990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G64_RS20015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G64_RS20020	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G64_RS20030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G64_RS20035	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G64_RS20080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G64_RS20085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G64_RS20125	COG0642	Histidine kinase
I6G64_RS20130	COG0697	spore germination
I6G64_RS20140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G64_RS20145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G64_RS20155	COG0586	Pfam SNARE associated Golgi protein
I6G64_RS20160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G64_RS20165	COG0285	dihydrofolate synthase activity
I6G64_RS20170	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6G64_RS20175	COG1286	toxin biosynthetic process
I6G64_RS20180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G64_RS20185	COG0163	prenyltransferase activity
I6G64_RS20190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS20195	COG4215	(ABC) transporter
I6G64_RS20205	COG4598	ABC transporter
I6G64_RS20210	COG1090	epimerase
I6G64_RS20215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G64_RS20220	COG0625	glutathione transferase activity
I6G64_RS20225	COG0622	Phosphoesterase
I6G64_RS20230	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G64_RS20235	COG3385	transposase activity
I6G64_RS20240	COG0857	belongs to the CobB CobQ family
I6G64_RS20240	COG0280	phosphate acetyltransferase
I6G64_RS20245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G64_RS20250	COG3092	negative regulation of chromosome organization
I6G64_RS20255	COG3013	Belongs to the UPF0304 family
I6G64_RS20260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G64_RS20265	COG0490	domain, Protein
I6G64_RS20265	COG0471	metal ion transport
I6G64_RS20270	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G64_RS20275	COG0436	Aminotransferase
I6G64_RS20280	COG0583	DNA-binding transcription factor activity
I6G64_RS20285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G64_RS20290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G64_RS20295	COG0649	NAD binding
I6G64_RS20295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G64_RS20310	COG1034	ATP synthesis coupled electron transport
I6G64_RS20315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6G64_RS20325	COG0839	Belongs to the complex I subunit 6 family
I6G64_RS20330	COG0713	ATP synthesis coupled electron transport
I6G64_RS20335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G64_RS20340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G64_RS20345	COG1007	ATP synthesis coupled electron transport
I6G64_RS20355	COG0028	Belongs to the TPP enzyme family
I6G64_RS20385	COG1609	Transcriptional regulator
I6G64_RS20390	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS20395	COG1063	alcohol dehydrogenase
I6G64_RS20400	COG4575	ribosome binding
I6G64_RS20405	COG3459	Glycosyltransferase 36 associated
I6G64_RS20410	COG1169	isochorismate synthase
I6G64_RS20415	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6G64_RS20420	COG0596	Alpha beta hydrolase
I6G64_RS20425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G64_RS20450	COG0814	amino acid
I6G64_RS20465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G64_RS20475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G64_RS20480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G64_RS20490	COG0784	Response regulator, receiver
I6G64_RS20490	COG2205	protein histidine kinase activity
I6G64_RS20500	COG0642	Histidine kinase
I6G64_RS20500	COG2198	Histidine kinase
I6G64_RS20505	COG2223	nitrite transmembrane transporter activity
I6G64_RS20520	COG0346	lactoylglutathione lyase activity
I6G64_RS20545	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G64_RS20560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G64_RS20560	COG2755	lipolytic protein G-D-S-L family
I6G64_RS20575	COG3082	Protein of unknown function (DUF1414)
I6G64_RS20580	COG3081	Nucleoid-associated protein
I6G64_RS20585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G64_RS20590	COG1061	Type III restriction enzyme res subunit
I6G64_RS20595	COG1187	pseudouridine synthase activity
I6G64_RS20600	COG2814	Major facilitator Superfamily
I6G64_RS20610	COG4172	Belongs to the ABC transporter superfamily
I6G64_RS20615	COG4239	(ABC) transporter, permease
I6G64_RS20620	COG4174	ABC transporter (Permease)
I6G64_RS20625	COG4166	transmembrane transport
I6G64_RS20630	COG2200	EAL domain
I6G64_RS20635	COG0791	NLP P60 protein
I6G64_RS20640	COG0671	phosphoesterase, PA-phosphatase related
I6G64_RS20645	COG0523	cobalamin synthesis protein
I6G64_RS20655	COG0246	Mannitol dehydrogenase
I6G64_RS20660	COG1312	Catalyzes the dehydration of D-mannonate
I6G64_RS20665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G64_RS20685	COG0243	molybdopterin cofactor binding
I6G64_RS20690	COG3005	denitrification pathway
I6G64_RS20695	COG0494	nUDIX hydrolase
I6G64_RS20705	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G64_RS20710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G64_RS20710	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G64_RS20710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G64_RS20715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6G64_RS20720	COG2855	membrane
I6G64_RS20725	COG0583	DNA-binding transcription factor activity
I6G64_RS20730	COG0833	amino acid
I6G64_RS20740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G64_RS20745	COG1120	ATPase activity
I6G64_RS20750	COG4771	TonB-dependent receptor
I6G64_RS20755	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS20760	COG1129	ABC transporter
I6G64_RS20765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G64_RS20770	COG1396	sequence-specific DNA binding
I6G64_RS20770	COG1917	Cupin 2, conserved barrel domain protein
I6G64_RS20775	COG0174	glutamine synthetase
I6G64_RS20780	COG0531	amino acid
I6G64_RS20785	COG2925	Exonuclease
I6G64_RS20810	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G64_RS20815	COG1289	transmembrane transporter activity
I6G64_RS20820	COG2926	Belongs to the UPF0265 family
I6G64_RS20825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS20830	COG1473	amidohydrolase
I6G64_RS20840	COG0431	NADPH-dependent FMN reductase
I6G64_RS20850	COG1022	Amp-dependent synthetase and ligase
I6G64_RS20865	COG2814	Major facilitator Superfamily
I6G64_RS20870	COG2207	Transcriptional regulator
I6G64_RS20905	COG2814	Major facilitator Superfamily
I6G64_RS20915	COG1174	glycine betaine transport
I6G64_RS20930	COG2986	histidine ammonia-lyase
I6G64_RS20965	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS21000	COG0583	DNA-binding transcription factor activity
I6G64_RS21005	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G64_RS21010	COG2207	Transcriptional regulator
I6G64_RS21015	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6G64_RS21020	COG3477	response to acidic pH
I6G64_RS21030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G64_RS21035	COG0022	dehydrogenase e1 component
I6G64_RS21040	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G64_RS21045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G64_RS21050	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS21070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G64_RS21130	COG0277	FAD linked oxidase domain protein
I6G64_RS21135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G64_RS21155	COG0251	oxidation-reduction process
I6G64_RS21160	COG0402	S-adenosylhomocysteine deaminase activity
I6G64_RS21170	COG0583	DNA-binding transcription factor activity
I6G64_RS21235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G64_RS21260	COG1201	RNA secondary structure unwinding
I6G64_RS21280	COG4565	transcriptional regulatory protein
I6G64_RS21285	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6G64_RS21290	COG3052	prosthetic group binding
I6G64_RS21295	COG2301	Belongs to the HpcH HpaI aldolase family
I6G64_RS21300	COG3051	citrate lyase alpha subunit
I6G64_RS21315	COG0471	metal ion transport
I6G64_RS21350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G64_RS21355	COG1063	alcohol dehydrogenase
I6G64_RS21360	COG2271	Major facilitator Superfamily
I6G64_RS21365	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS21375	COG2186	Transcriptional regulator
I6G64_RS21395	COG0601	transmembrane transport
I6G64_RS21400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G64_RS21405	COG4172	Belongs to the ABC transporter superfamily
I6G64_RS21410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS21425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS21440	COG0859	PFAM glycosyl transferase family 9
I6G64_RS21450	COG0583	DNA-binding transcription factor activity
I6G64_RS21470	COG3238	Protein conserved in bacteria
I6G64_RS21485	COG2223	nitrite transmembrane transporter activity
I6G64_RS21490	COG4774	siderophore transport
I6G64_RS21525	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6G64_RS21540	COG0737	Belongs to the 5'-nucleotidase family
I6G64_RS21545	COG0738	Major facilitator superfamily
I6G64_RS21550	COG0583	DNA-binding transcription factor activity
I6G64_RS21565	COG0583	DNA-binding transcription factor activity
I6G64_RS21580	COG2207	Transcriptional regulator
I6G64_RS21585	COG1881	PFAM PEBP family protein
I6G64_RS21620	COG1522	sequence-specific DNA binding
I6G64_RS21635	COG2897	thiosulfate sulfurtransferase activity
I6G64_RS21650	COG0626	cystathionine gamma-synthase activity
I6G64_RS21670	COG1733	regulation of RNA biosynthetic process
I6G64_RS21705	COG3772	lysozyme
I6G64_RS21780	COG1222	aaa ATPase
I6G64_RS21825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G64_RS21840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G64_RS21845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G64_RS21850	COG1116	anion transmembrane transporter activity
I6G64_RS21855	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G64_RS21860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS21880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G64_RS21890	COG3842	ATPase activity
I6G64_RS21900	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G64_RS21905	COG1609	Transcriptional regulator
I6G64_RS21910	COG3284	Transcriptional regulator
I6G64_RS21915	COG0095	Lipoate-protein ligase
I6G64_RS21920	COG1063	alcohol dehydrogenase
I6G64_RS21950	COG3706	GGDEF domain
I6G64_RS21960	COG1902	pentaerythritol trinitrate reductase activity
I6G64_RS21975	COG0604	alcohol dehydrogenase
I6G64_RS21985	COG3228	Belongs to the MtfA family
I6G64_RS22010	COG0534	Mate efflux family protein
I6G64_RS22020	COG1486	melibiose metabolic process
I6G64_RS22025	COG2223	nitrite transmembrane transporter activity
I6G64_RS22035	COG4993	Dehydrogenase
I6G64_RS22090	COG0625	glutathione transferase activity
I6G64_RS22095	COG0583	DNA-binding transcription factor activity
I6G64_RS22115	COG1113	amino acid transport
I6G64_RS22120	COG0697	spore germination
I6G64_RS22125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G64_RS22130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G64_RS22135	COG3327	negative regulation of DNA-templated transcription, initiation
I6G64_RS22140	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6G64_RS22145	COG2050	protein possibly involved in aromatic compounds catabolism
I6G64_RS22150	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G64_RS22155	COG1024	Enoyl-CoA hydratase
I6G64_RS22160	COG1024	Enoyl-CoA hydratase
I6G64_RS22165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G64_RS22170	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G64_RS22175	COG3396	Phenylacetate-CoA oxygenase
I6G64_RS22180	COG3460	Phenylacetate-CoA oxygenase
I6G64_RS22185	COG3396	Phenylacetate-CoA oxygenase
I6G64_RS22190	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS22190	COG2030	dehydratase
I6G64_RS22195	COG2203	Gaf domain
I6G64_RS22195	COG5001	Diguanylate cyclase
I6G64_RS22195	COG4251	negative regulation of phosphorylation
I6G64_RS22195	COG3706	GGDEF domain
I6G64_RS22205	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6G64_RS22210	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS22215	COG0583	DNA-binding transcription factor activity
I6G64_RS22225	COG2261	transglycosylase associated protein
I6G64_RS22230	COG3753	Protein conserved in bacteria
I6G64_RS22250	COG3321	synthase
I6G64_RS22250	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS22250	COG0604	alcohol dehydrogenase
I6G64_RS22295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G64_RS22305	COG1285	pathogenesis
I6G64_RS22345	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6G64_RS22355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G64_RS22360	COG1393	Belongs to the ArsC family
I6G64_RS22365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G64_RS22370	COG0183	Belongs to the thiolase family
I6G64_RS22375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G64_RS22385	COG1414	Transcriptional regulator
I6G64_RS22400	COG4191	Histidine kinase
I6G64_RS22405	COG4753	response regulator
I6G64_RS22405	COG2207	Transcriptional regulator
I6G64_RS22450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G64_RS22455	COG1609	Transcriptional regulator
I6G64_RS22460	COG2211	Major facilitator Superfamily
I6G64_RS22475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G64_RS22500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G64_RS22510	COG3483	tryptophan 2,3-dioxygenase activity
I6G64_RS22515	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6G64_RS22520	COG2130	NADP-dependent
I6G64_RS22535	COG3385	transposase activity
I6G64_RS22560	COG2198	Histidine kinase
I6G64_RS22560	COG0643	Histidine kinase
I6G64_RS22565	COG0835	chemotaxis
I6G64_RS22575	COG0840	transmembrane signaling receptor activity
I6G64_RS22580	COG0840	transmembrane signaling receptor activity
I6G64_RS22585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G64_RS22595	COG0745	RESPONSE REGULATOR receiver
I6G64_RS22600	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G64_RS22605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G64_RS22610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G64_RS22630	COG3418	PFAM FlgN family protein
I6G64_RS22635	COG2747	anti-sigma28 factor FlgM
I6G64_RS22645	COG1815	bacterial-type flagellum-dependent cell motility
I6G64_RS22650	COG1558	bacterial-type flagellum-dependent cell motility
I6G64_RS22655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6G64_RS22670	COG4786	Flagellar basal body rod
I6G64_RS22690	COG1256	bacterial-type flagellum assembly
I6G64_RS22755	COG2882	bacterial-type flagellum organization
I6G64_RS22760	COG1157	protein secretion by the type III secretion system
I6G64_RS22765	COG1317	bacterial-type flagellum organization
I6G64_RS22770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G64_RS22780	COG1677	Flagellar hook-basal body complex protein FliE
I6G64_RS22825	COG1191	sigma factor activity
I6G64_RS22835	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G64_RS22840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS22845	COG0765	amino acid transport
I6G64_RS22850	COG1126	abc transporter atp-binding protein
I6G64_RS22865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G64_RS22865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G64_RS22865	COG0506	proline dehydrogenase activity
I6G64_RS22875	COG0672	)-iron permease
I6G64_RS22890	COG4772	TonB-dependent receptor
I6G64_RS22900	COG1702	phosphate starvation-inducible protein PhoH
I6G64_RS22910	COG0387	Pfam Sodium calcium exchanger
I6G64_RS22915	COG2375	cellular response to nickel ion
I6G64_RS22920	COG4572	Cation transport regulator
I6G64_RS22925	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6G64_RS22930	COG0583	DNA-binding transcription factor activity
I6G64_RS22935	COG4166	transmembrane transport
I6G64_RS22940	COG0601	transmembrane transport
I6G64_RS22945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G64_RS22950	COG0444	Belongs to the ABC transporter superfamily
I6G64_RS22955	COG4608	Belongs to the ABC transporter superfamily
I6G64_RS22965	COG3707	response regulator
I6G64_RS22970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G64_RS22980	COG1116	anion transmembrane transporter activity
I6G64_RS22985	COG2146	nitrite reductase [NAD(P)H] activity
I6G64_RS22985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G64_RS22990	COG0243	molybdopterin cofactor binding
I6G64_RS22995	COG1648	precorrin-2 dehydrogenase activity
I6G64_RS22995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G64_RS23015	COG4932	domain protein
I6G64_RS23020	COG2197	response regulator
I6G64_RS23025	COG3850	Histidine kinase
I6G64_RS23030	COG2223	nitrite transmembrane transporter activity
I6G64_RS23035	COG3710	Transcriptional regulator
I6G64_RS23040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G64_RS23045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G64_RS23070	COG0463	Glycosyl transferase, family 2
I6G64_RS23080	COG1215	transferase activity, transferring glycosyl groups
I6G64_RS23090	COG1216	Glycosyl transferase, family 2
I6G64_RS23095	COG0463	Glycosyl transferase, family 2
I6G64_RS23105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G64_RS23110	COG2431	L-lysine efflux transmembrane transporter activity
I6G64_RS23140	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G64_RS23145	COG1140	nitrate reductase beta subunit
I6G64_RS23150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G64_RS23155	COG2181	nitrate reductase activity
I6G64_RS23160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G64_RS23165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G64_RS23215	COG1294	oxidase, subunit
I6G64_RS23220	COG1271	oxidase subunit
I6G64_RS23225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G64_RS23235	COG0601	transmembrane transport
I6G64_RS23245	COG0444	Belongs to the ABC transporter superfamily
I6G64_RS23250	COG4608	Belongs to the ABC transporter superfamily
I6G64_RS23260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G64_RS23265	COG3138	arginine N-succinyltransferase
I6G64_RS23270	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS23275	COG3724	N-succinylarginine dihydrolase activity
I6G64_RS23280	COG2988	succinylglutamate desuccinylase activity
I6G64_RS23300	COG1652	LysM domain
I6G64_RS23325	COG2207	Transcriptional regulator
I6G64_RS23370	COG1113	amino acid transport
I6G64_RS23400	COG2226	methyltransferase
I6G64_RS23405	COG0640	Transcriptional regulator
I6G64_RS23415	COG1971	Probably functions as a manganese efflux pump
I6G64_RS23420	COG4811	Protein of unknown function (DUF986)
I6G64_RS23425	COG3716	PTS system mannose fructose sorbose family IID component
I6G64_RS23430	COG3715	PTS system
I6G64_RS23435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G64_RS23435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS23440	COG1253	flavin adenine dinucleotide binding
I6G64_RS23445	COG2200	EAL domain
I6G64_RS23450	COG1760	l-serine dehydratase
I6G64_RS23455	COG0494	nUDIX hydrolase
I6G64_RS23465	COG1216	Glycosyl transferase, family 2
I6G64_RS23470	COG3140	Belongs to the UPF0181 family
I6G64_RS23475	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6G64_RS23480	COG0513	Belongs to the DEAD box helicase family
I6G64_RS23485	COG3141	response to X-ray
I6G64_RS23490	COG3097	Belongs to the UPF0267 family
I6G64_RS23510	COG2999	glutathione oxidoreductase activity
I6G64_RS23520	COG0477	Major facilitator Superfamily
I6G64_RS23525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G64_RS23530	COG3132	Protein of unknown function, DUF480
I6G64_RS23545	COG3385	transposase activity
I6G64_RS23550	COG0018	arginyl-trna synthetase
I6G64_RS23555	COG3102	Protein conserved in bacteria
I6G64_RS23560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G64_RS23565	COG3142	Participates in the control of copper homeostasis
I6G64_RS23580	COG0500	methyltransferase
I6G64_RS23585	COG2226	methyltransferase
I6G64_RS23590	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6G64_RS23595	COG1801	Protein of unknown function DUF72
I6G64_RS23600	COG1335	isochorismatase
I6G64_RS23610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G64_RS23615	COG0494	nUDIX hydrolase
I6G64_RS23620	COG0217	transcriptional regulatory protein
I6G64_RS23625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6G64_RS23630	COG0632	four-way junction helicase activity
I6G64_RS23635	COG2255	four-way junction helicase activity
I6G64_RS23640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G64_RS23645	COG1121	(ABC) transporter
I6G64_RS23650	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6G64_RS23655	COG0739	heme binding
I6G64_RS23660	COG1560	Kdo2-lipid A biosynthetic process
I6G64_RS23670	COG0469	pyruvate kinase activity
I6G64_RS23675	COG1737	Transcriptional regulator
I6G64_RS23680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G64_RS23685	COG0800	Aldolase
I6G64_RS23690	COG2076	Multidrug Resistance protein
I6G64_RS23695	COG2076	Multidrug Resistance protein
I6G64_RS23700	COG0251	oxidation-reduction process
I6G64_RS23705	COG1199	ATP-dependent helicase activity
I6G64_RS23715	COG3065	identical protein binding
I6G64_RS23720	COG0318	PFAM AMP-dependent synthetase and ligase
I6G64_RS23725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6G64_RS23730	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G64_RS23735	COG2894	cell division
I6G64_RS23740	COG0850	regulation of cytokinetic process
I6G64_RS23745	COG3100	YcgL domain-containing protein
I6G64_RS23750	COG2951	lytic endotransglycosylase activity
I6G64_RS23755	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G64_RS23765	COG2983	Belongs to the UPF0260 family
I6G64_RS23770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G64_RS23775	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G64_RS23780	COG2186	Transcriptional regulator
I6G64_RS23790	COG2719	SpoVR family
I6G64_RS23795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G64_RS23800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G64_RS23815	COG0601	transmembrane transport
I6G64_RS23845	COG4774	siderophore transport
I6G64_RS23855	COG0401	homolog of Blt101
I6G64_RS23875	COG2718	Belongs to the UPF0229 family
I6G64_RS23880	COG2766	serine protein kinase
I6G64_RS23885	COG3713	MltA-interacting MipA family protein
I6G64_RS23895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G64_RS23900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G64_RS23905	COG3139	Protein of unknown function (DUF1315)
I6G64_RS23915	COG1335	isochorismatase
I6G64_RS23920	COG0252	asparaginase activity
I6G64_RS23925	COG0616	signal peptide processing
I6G64_RS23930	COG0778	Nitroreductase
I6G64_RS23940	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G64_RS23945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G64_RS23955	COG0494	nUDIX hydrolase
I6G64_RS23960	COG0708	Exodeoxyribonuclease III
I6G64_RS23995	COG0788	formyltetrahydrofolate deformylase activity
I6G64_RS24000	COG3012	SEC-C Motif Domain Protein
I6G64_RS24005	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G64_RS24010	COG0745	RESPONSE REGULATOR receiver
I6G64_RS24015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G64_RS24040	COG1454	alcohol dehydrogenase
I6G64_RS24040	COG1012	belongs to the aldehyde dehydrogenase family
I6G64_RS24045	COG2095	MarC family integral membrane protein
I6G64_RS24050	COG4166	transmembrane transport
I6G64_RS24065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G64_RS24070	COG0444	Belongs to the ABC transporter superfamily
I6G64_RS24080	COG3099	Belongs to the UPF0263 family
I6G64_RS24085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G64_RS24110	COG2350	Protein conserved in bacteria
I6G64_RS24115	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G64_RS24125	COG1607	acyl-coa hydrolase
I6G64_RS24130	COG2917	probably involved in intracellular septation
I6G64_RS24145	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6G64_RS24150	COG3047	cAMP biosynthetic process
I6G64_RS24160	COG0159	tryptophan synthase activity
I6G64_RS24165	COG0133	tryptophan synthase activity
I6G64_RS24175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G64_RS24190	COG0613	PHP domain protein
I6G64_RS24195	COG0009	L-threonylcarbamoyladenylate synthase
I6G64_RS24210	COG1187	pseudouridine synthase activity
I6G64_RS24215	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6G64_RS24220	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS24225	COG0616	signal peptide processing
I6G64_RS24240	COG0583	DNA-binding transcription factor activity
I6G64_RS24250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G64_RS24260	COG0671	phosphoesterase, PA-phosphatase related
I6G64_RS24265	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6G64_RS24270	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G64_RS24290	COG0023	Translation Initiation Factor
I6G64_RS24300	COG0235	Class ii aldolase
I6G64_RS24305	COG1349	DNA-binding transcription factor activity
I6G64_RS24310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G64_RS24315	COG1966	Carbon starvation protein
I6G64_RS24320	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6G64_RS24325	COG0243	molybdopterin cofactor binding
I6G64_RS24340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G64_RS24340	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G64_RS24350	COG4172	Belongs to the ABC transporter superfamily
I6G64_RS24355	COG4171	peptide transport system, permease
I6G64_RS24360	COG4168	peptide transport system, permease
I6G64_RS24370	COG1469	GTP cyclohydrolase I activity
I6G64_RS24385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G64_RS24390	COG1842	Phage shock protein A
I6G64_RS24400	COG1983	PspC domain protein
I6G64_RS24415	COG3106	COG3106 Predicted ATPase
I6G64_RS24420	COG3768	UPF0283 membrane protein
I6G64_RS24435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G64_RS24440	COG4948	Mandelate Racemase Muconate Lactonizing
I6G64_RS24445	COG2866	Carboxypeptidase
I6G64_RS24455	COG4166	transmembrane transport
I6G64_RS24475	COG0037	tRNA processing
I6G64_RS24510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G64_RS24510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G64_RS24510	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G64_RS24510	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G64_RS24520	COG3042	response to heat
I6G64_RS24525	COG3187	Heat shock protein
I6G64_RS24530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G64_RS24535	COG2911	Protein conserved in bacteria
I6G64_RS24545	COG3784	Protein of unknown function (DUF1318)
I6G64_RS24550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G64_RS24555	COG1643	Atp-dependent helicase
I6G64_RS24560	COG3591	Belongs to the peptidase S1B family
I6G64_RS24575	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6G64_RS24580	COG2205	protein histidine kinase activity
I6G64_RS24585	COG0745	RESPONSE REGULATOR receiver
I6G64_RS24600	COG0531	amino acid
I6G64_RS24610	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6G64_RS24615	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6G64_RS24620	COG0589	response to stress
I6G64_RS24630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G64_RS24650	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6G64_RS24655	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6G64_RS24675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G64_RS24680	COG1686	Belongs to the peptidase S11 family
I6G64_RS24690	COG0306	phosphate transporter
I6G64_RS24750	COG3158	transport of potassium into the cell
I6G64_RS24775	COG0657	acetylesterase activity
I6G64_RS24805	COG0697	spore germination
I6G64_RS24810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G64_RS24830	COG0583	DNA-binding transcription factor activity
I6G64_RS24845	COG2239	Acts as a magnesium transporter
I6G64_RS24865	COG2207	Transcriptional regulator
I6G64_RS24865	COG1917	Cupin 2, conserved barrel domain protein
I6G64_RS24875	COG0488	(ABC) transporter
I6G64_RS24880	COG1196	nuclear chromosome segregation
I6G64_RS24880	COG3264	Mechanosensitive ion channel
I6G64_RS24890	COG1263	PTS System
I6G64_RS24890	COG2190	(PTS) system
I6G64_RS24890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G64_RS24895	COG0583	DNA-binding transcription factor activity
I6G64_RS24900	COG1653	transport
I6G64_RS24920	COG3842	ATPase activity
I6G64_RS24925	COG0366	Alpha amylase catalytic
I6G64_RS24935	COG1129	ABC transporter
I6G64_RS24940	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS24945	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G64_RS24955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G64_RS24975	COG2011	ABC-type metal ion transport system permease component
I6G64_RS24980	COG2199	diguanylate cyclase activity
I6G64_RS24985	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6G64_RS25000	COG3048	D-serine ammonia-lyase activity
I6G64_RS25005	COG1414	Transcriptional regulator
I6G64_RS25025	COG1082	Xylose isomerase domain protein TIM barrel
I6G64_RS25025	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6G64_RS25030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G64_RS25040	COG2814	Major facilitator Superfamily
I6G64_RS25055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G64_RS25060	COG0583	DNA-binding transcription factor activity
I6G64_RS25065	COG3485	protocatechuate 3,4-dioxygenase
I6G64_RS25070	COG3485	protocatechuate 3,4-dioxygenase
I6G64_RS25080	COG2723	6-phospho-beta-galactosidase activity
I6G64_RS25090	COG2271	Major facilitator Superfamily
I6G64_RS25095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G64_RS25105	COG1045	serine acetyltransferase
I6G64_RS25110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G64_RS25115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G64_RS25125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G64_RS25130	COG2011	ABC-type metal ion transport system permease component
I6G64_RS25160	COG0583	DNA-binding transcription factor activity
I6G64_RS25175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G64_RS25180	COG3135	benzoate transporter
I6G64_RS25215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G64_RS25230	COG0693	protein deglycase activity
I6G64_RS25245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G64_RS25285	COG1733	regulation of RNA biosynthetic process
I6G64_RS25290	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G64_RS25295	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G64_RS25300	COG0583	DNA-binding transcription factor activity
I6G64_RS25305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G64_RS25320	COG0778	Nitroreductase
I6G64_RS25325	COG0697	spore germination
I6G64_RS25330	COG1846	Transcriptional regulator
I6G64_RS25335	COG0702	epimerase
I6G64_RS25340	COG1733	regulation of RNA biosynthetic process
I6G64_RS25350	COG1028	Short-chain dehydrogenase reductase Sdr
I6G64_RS25360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G64_RS25365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G64_RS25380	COG4580	involved in the transport of maltose and maltodextrins
I6G64_RS25385	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G64_RS25390	COG2723	6-phospho-beta-galactosidase activity
I6G64_RS25395	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G64_RS25395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G64_RS25405	COG1609	Transcriptional regulator
I6G64_RS25415	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G64_RS25420	COG3713	MltA-interacting MipA family protein
I6G64_RS25445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G64_RS25450	COG0076	glutamate decarboxylase activity
I6G64_RS25475	COG4993	Dehydrogenase
I6G64_RS25490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G64_RS25505	COG3284	Transcriptional regulator