locus-tag	class	description
Q5A_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Q5A_RS00010	COG0592	DNA-directed DNA polymerase activity
Q5A_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Q5A_RS00020	COG0187	DNA topoisomerase II activity
Q5A_RS00025	COG0561	phosphatase activity
Q5A_RS00030	COG2423	ornithine cyclodeaminase activity
Q5A_RS00035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Q5A_RS00045	COG0823	Involved in the tonB-independent uptake of proteins
Q5A_RS00050	COG5645	(Lipo)protein
Q5A_RS00055	COG0071	Belongs to the small heat shock protein (HSP20) family
Q5A_RS00060	COG0071	Belongs to the small heat shock protein (HSP20) family
Q5A_RS00065	COG2985	domain, Protein
Q5A_RS00070	COG3977	Valine--pyruvate aminotransferase
Q5A_RS00075	COG0366	Alpha amylase catalytic
Q5A_RS00080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Q5A_RS00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Q5A_RS00100	COG1609	Transcriptional regulator
Q5A_RS00105	COG2885	chlorophyll binding
Q5A_RS00110	COG0456	acetyltransferase
Q5A_RS00115	COG2818	Glycosylase
Q5A_RS00125	COG2271	Major facilitator Superfamily
Q5A_RS00130	COG0752	glycyl-tRNA synthetase alpha subunit
Q5A_RS00135	COG0751	glycine-tRNA ligase activity
Q5A_RS00150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Q5A_RS00150	COG2213	PTS system mannitol-specific
Q5A_RS00155	COG0246	Mannitol dehydrogenase
Q5A_RS00160	COG3722	fumarate hydratase activity
Q5A_RS00170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Q5A_RS00185	COG2258	MOSC domain
Q5A_RS00190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Q5A_RS00200	COG3383	formate dehydrogenase (NAD+) activity
Q5A_RS00200	COG0243	molybdopterin cofactor binding
Q5A_RS00205	COG3383	formate dehydrogenase (NAD+) activity
Q5A_RS00205	COG0243	molybdopterin cofactor binding
Q5A_RS00210	COG0437	4 iron, 4 sulfur cluster binding
Q5A_RS00215	COG2864	formate dehydrogenase
Q5A_RS00220	COG3058	Necessary for formate dehydrogenase activity
Q5A_RS00230	COG0625	glutathione transferase activity
Q5A_RS00235	COG1921	L-seryl-tRNASec selenium transferase activity
Q5A_RS00240	COG3276	selenocysteine insertion sequence binding
Q5A_RS00245	COG3385	transposase activity
Q5A_RS00255	COG3274	enterobacterial common antigen metabolic process
Q5A_RS00265	COG1335	isochorismatase
Q5A_RS00270	COG0402	S-adenosylhomocysteine deaminase activity
Q5A_RS00275	COG1070	Carbohydrate kinase
Q5A_RS00280	COG2115	Belongs to the xylose isomerase family
Q5A_RS00285	COG4213	ABC transporter substrate-binding protein
Q5A_RS00290	COG1129	ABC transporter
Q5A_RS00295	COG4214	carbohydrate transport
Q5A_RS00300	COG2207	Transcriptional regulator
Q5A_RS00300	COG1609	Transcriptional regulator
Q5A_RS00315	COG0583	DNA-binding transcription factor activity
Q5A_RS00320	COG2807	transmembrane transport
Q5A_RS00350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Q5A_RS00360	COG2801	Transposase and inactivated derivatives
Q5A_RS00400	COG2814	Major facilitator Superfamily
Q5A_RS00405	COG0583	DNA-binding transcription factor activity
Q5A_RS00430	COG2197	response regulator
Q5A_RS00435	COG1538	Outer membrane efflux protein
Q5A_RS00465	COG3121	Chaperone
Q5A_RS00510	COG1846	Transcriptional regulator
Q5A_RS00515	COG1764	response to oxidative stress
Q5A_RS00520	COG2194	sulfuric ester hydrolase activity
Q5A_RS00525	COG2197	response regulator
Q5A_RS00535	COG2271	Major facilitator Superfamily
Q5A_RS00555	COG0747	negative chemotaxis
Q5A_RS00560	COG0601	transmembrane transport
Q5A_RS00565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Q5A_RS00570	COG0444	Belongs to the ABC transporter superfamily
Q5A_RS00575	COG4608	Belongs to the ABC transporter superfamily
Q5A_RS00580	COG2194	sulfuric ester hydrolase activity
Q5A_RS00610	COG1215	transferase activity, transferring glycosyl groups
Q5A_RS00615	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Q5A_RS00620	COG0457	Tetratricopeptide repeat
Q5A_RS00620	COG3118	belongs to the thioredoxin family
Q5A_RS00625	COG2199	diguanylate cyclase activity
Q5A_RS00625	COG2200	EAL domain
Q5A_RS00630	COG1301	dicarboxylic acid transport
Q5A_RS00635	COG0612	Peptidase, M16
Q5A_RS00640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Q5A_RS00650	COG0248	Ppx GppA phosphatase
Q5A_RS00655	COG0513	Belongs to the DEAD box helicase family
Q5A_RS00660	COG3118	belongs to the thioredoxin family
Q5A_RS00665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Q5A_RS00670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Q5A_RS00680	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Q5A_RS00685	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Q5A_RS00690	COG1088	dTDP-glucose 4,6-dehydratase activity
Q5A_RS00695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Q5A_RS00700	COG0456	acetyltransferase
Q5A_RS00705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Q5A_RS00710	COG2244	polysaccharide biosynthetic process
Q5A_RS00715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Q5A_RS00725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Q5A_RS00760	COG3071	HemY protein
Q5A_RS00765	COG2959	enzyme of heme biosynthesis
Q5A_RS00775	COG0181	hydroxymethylbilane synthase activity
Q5A_RS00780	COG3072	Adenylate cyclase
Q5A_RS00785	COG1965	Belongs to the frataxin family
Q5A_RS00795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Q5A_RS00800	COG3159	Protein conserved in bacteria
Q5A_RS00810	COG1011	Hydrolase
Q5A_RS00815	COG0210	DNA helicase
Q5A_RS00830	COG3180	Ammonia monooxygenase
Q5A_RS00840	COG2050	protein possibly involved in aromatic compounds catabolism
Q5A_RS00845	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Q5A_RS00855	COG1280	lysine exporter protein (LysE YggA)
Q5A_RS00860	COG1280	lysine exporter protein (LysE YggA)
Q5A_RS00865	COG2267	carboxylic ester hydrolase activity
Q5A_RS00870	COG0561	phosphatase activity
Q5A_RS00875	COG0584	glycerophosphoryl diester phosphodiesterase
Q5A_RS00880	COG2271	Major facilitator Superfamily
Q5A_RS00885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Q5A_RS00895	COG0247	lactate metabolic process
Q5A_RS00910	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Q5A_RS00915	COG0425	Belongs to the sulfur carrier protein TusA family
Q5A_RS00930	COG2217	Heavy metal translocating P-type atpase
Q5A_RS00945	COG3714	YhhN family
Q5A_RS00955	COG3776	membrane
Q5A_RS00960	COG0742	ribosomal rna small subunit methyltransferase
Q5A_RS00965	COG0552	protein localization to endoplasmic reticulum
Q5A_RS00970	COG2884	Cell division ATP-binding protein ftsE
Q5A_RS00975	COG2177	Part of the ABC transporter FtsEX involved in
Q5A_RS00995	COG0456	acetyltransferase
Q5A_RS01005	COG0559	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS01010	COG4177	L-phenylalanine transmembrane transporter activity
Q5A_RS01020	COG0410	ABC transporter
Q5A_RS01025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Q5A_RS01030	COG1653	transport
Q5A_RS01035	COG1175	transmembrane transport
Q5A_RS01045	COG3842	ATPase activity
Q5A_RS01050	COG0584	glycerophosphoryl diester phosphodiesterase
Q5A_RS01065	COG0583	DNA-binding transcription factor activity
Q5A_RS01070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Q5A_RS01075	COG2207	Transcriptional regulator
Q5A_RS01080	COG0412	Dienelactone hydrolase
Q5A_RS01095	COG0586	Pfam SNARE associated Golgi protein
Q5A_RS01100	COG1322	Protein conserved in bacteria
Q5A_RS01105	COG2226	methyltransferase
Q5A_RS01115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Q5A_RS01120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Q5A_RS01130	COG0805	protein transport
Q5A_RS01135	COG0084	hydrolase, TatD family'
Q5A_RS01170	COG0183	Belongs to the thiolase family
Q5A_RS01175	COG1024	Enoyl-CoA hydratase
Q5A_RS01175	COG1250	3-hydroxyacyl-CoA dehydrogenase
Q5A_RS01180	COG2271	Major facilitator Superfamily
Q5A_RS01185	COG0006	proline dipeptidase activity
Q5A_RS01190	COG1739	Uncharacterized protein family UPF0029
Q5A_RS01195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Q5A_RS01225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Q5A_RS01230	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Q5A_RS01230	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Q5A_RS01235	COG1072	(Pantothenic acid kinase))
Q5A_RS01270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Q5A_RS01280	COG0250	Participates in transcription elongation, termination and antitermination
Q5A_RS01285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Q5A_RS01290	COG0081	regulation of translation
Q5A_RS01295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Q5A_RS01300	COG0222	ribosome binding
Q5A_RS01305	COG0085	RNA polymerase activity
Q5A_RS01310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Q5A_RS01325	COG2022	thiamine diphosphate biosynthetic process
Q5A_RS01330	COG2104	thiamine diphosphate biosynthetic process
Q5A_RS01335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Q5A_RS01340	COG0352	thiamine-phosphate diphosphorylase activity
Q5A_RS01350	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Q5A_RS01355	COG2816	NAD+ diphosphatase activity
Q5A_RS01360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Q5A_RS01365	COG1515	deoxyribonuclease V activity
Q5A_RS01385	COG0151	Belongs to the GarS family
Q5A_RS01390	COG0138	bifunctional purine biosynthesis protein purh
Q5A_RS01420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Q5A_RS01425	COG3162	membrane
Q5A_RS01430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Q5A_RS01435	COG1301	dicarboxylic acid transport
Q5A_RS01440	COG0288	reversible hydration of carbon dioxide
Q5A_RS01445	COG0659	secondary active sulfate transmembrane transporter activity
Q5A_RS01460	COG0745	RESPONSE REGULATOR receiver
Q5A_RS01475	COG3188	usher protein
Q5A_RS01480	COG3121	Chaperone
Q5A_RS01490	COG3539	Fimbrial protein
Q5A_RS01505	COG2197	response regulator
Q5A_RS01525	COG2814	Major facilitator Superfamily
Q5A_RS01535	COG1309	transcriptional regulator
Q5A_RS01540	COG4232	protein-disulfide reductase activity
Q5A_RS01550	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Q5A_RS01565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Q5A_RS01570	COG0459	protein refolding
Q5A_RS01585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Q5A_RS01590	COG5510	response to toxic substance
Q5A_RS01605	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Q5A_RS01610	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Q5A_RS01615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Q5A_RS01620	COG1053	succinate dehydrogenase
Q5A_RS01625	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Q5A_RS01630	COG3264	Mechanosensitive ion channel
Q5A_RS01630	COG1511	domain protein
Q5A_RS01635	COG0688	phosphatidylethanolamine metabolic process
Q5A_RS01640	COG1162	GTPase activity
Q5A_RS01645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Q5A_RS01665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Q5A_RS01670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Q5A_RS01670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Q5A_RS01675	COG0802	atpase or kinase
Q5A_RS01685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Q5A_RS01690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Q5A_RS01695	COG1923	regulation of RNA biosynthetic process
Q5A_RS01700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Q5A_RS01705	COG0330	HflC and HflK could
Q5A_RS01710	COG0330	HflC and HflK could
Q5A_RS01715	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Q5A_RS01720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Q5A_RS01725	COG1959	2 iron, 2 sulfur cluster binding
Q5A_RS01730	COG0557	exoribonuclease II activity
Q5A_RS01735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Q5A_RS01740	COG1960	acyl-CoA dehydrogenase activity
Q5A_RS01745	COG3766	membrane
Q5A_RS01755	COG3650	response to hydrogen peroxide
Q5A_RS01760	COG1073	alpha beta
Q5A_RS01775	COG0360	Binds together with S18 to 16S ribosomal RNA
Q5A_RS01780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Q5A_RS01785	COG0359	binds to the 23S rRNA
Q5A_RS01795	COG3061	Opacity-associated protein A
Q5A_RS01800	COG0545	Peptidyl-prolyl cis-trans isomerase
Q5A_RS01805	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Q5A_RS01810	COG0737	Belongs to the 5'-nucleotidase family
Q5A_RS01815	COG1218	3'(2'),5'-bisphosphate nucleotidase
Q5A_RS01820	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Q5A_RS01830	COG1253	flavin adenine dinucleotide binding
Q5A_RS01835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Q5A_RS01840	COG0729	surface antigen
Q5A_RS01845	COG2911	Protein conserved in bacteria
Q5A_RS01850	COG2105	PFAM AIG2 family protein
Q5A_RS01855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Q5A_RS01865	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Q5A_RS01870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Q5A_RS01885	COG1438	arginine binding
Q5A_RS01890	COG0039	L-malate dehydrogenase activity
Q5A_RS01895	COG3423	Transcriptional regulator
Q5A_RS01905	COG0142	geranyltranstransferase activity
Q5A_RS01910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Q5A_RS01915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Q5A_RS01920	COG0697	spore germination
Q5A_RS01925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Q5A_RS01930	COG0642	Histidine kinase
Q5A_RS01935	COG0745	RESPONSE REGULATOR receiver
Q5A_RS01940	COG2027	D-alanyl-D-alanine carboxypeptidase
Q5A_RS01950	COG1534	Rna-binding protein
Q5A_RS01955	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Q5A_RS01965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Q5A_RS01970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Q5A_RS01975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Q5A_RS01990	COG0779	Required for maturation of 30S ribosomal subunits
Q5A_RS01995	COG0195	Participates in both transcription termination and antitermination
Q5A_RS02000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Q5A_RS02005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Q5A_RS02010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Q5A_RS02015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Q5A_RS02020	COG1185	polyribonucleotide nucleotidyltransferase activity
Q5A_RS02030	COG0513	Belongs to the DEAD box helicase family
Q5A_RS02035	COG2391	methyltransferase activity
Q5A_RS02040	COG0425	Belongs to the sulfur carrier protein TusA family
Q5A_RS02050	COG0477	Major facilitator Superfamily
Q5A_RS02055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Q5A_RS02090	COG0826	peptidase U32
Q5A_RS02095	COG0826	peptidase U32
Q5A_RS02100	COG3154	lipid carrier protein
Q5A_RS02105	COG3153	acetyltransferase
Q5A_RS02110	COG2827	Endonuclease containing a URI domain
Q5A_RS02115	COG1518	maintenance of DNA repeat elements
Q5A_RS02120	COG1203	CRISPR-associated helicase, Cas3
Q5A_RS02145	COG3787	Belongs to the UPF0306 family
Q5A_RS02150	COG0702	epimerase
Q5A_RS02155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Q5A_RS02165	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Q5A_RS02170	COG3454	Phosphonate metabolism
Q5A_RS02175	COG4778	phosphonate C-P lyase system protein PhnL
Q5A_RS02180	COG4107	phosphonate C-P lyase system protein PhnK
Q5A_RS02185	COG3627	carbon phosphorus lyase activity
Q5A_RS02190	COG3626	phosphonate metabolism
Q5A_RS02195	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Q5A_RS02200	COG3624	Phosphonate C-P lyase system protein PhnG
Q5A_RS02205	COG2188	Transcriptional regulator
Q5A_RS02210	COG0701	Predicted permease
Q5A_RS02240	COG0583	DNA-binding transcription factor activity
Q5A_RS02245	COG2249	NAD(P)H dehydrogenase (quinone) activity
Q5A_RS02250	COG0366	Alpha amylase catalytic
Q5A_RS02255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS02255	COG1263	PTS System
Q5A_RS02265	COG1609	Transcriptional regulator
Q5A_RS02270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Q5A_RS02290	COG2308	Evidence 4 Homologs of previously reported genes of
Q5A_RS02305	COG0540	Belongs to the ATCase OTCase family
Q5A_RS02315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Q5A_RS02320	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
Q5A_RS02330	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Q5A_RS02340	COG0456	acetyltransferase
Q5A_RS02350	COG2927	DNA polymerase III (CHI subunit)
Q5A_RS02355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Q5A_RS02360	COG0795	lipopolysaccharide-transporting ATPase activity
Q5A_RS02365	COG0795	lipopolysaccharide-transporting ATPase activity
Q5A_RS02420	COG1475	DNA binding
Q5A_RS02435	COG3727	T/G mismatch-specific endonuclease activity
Q5A_RS02450	COG2723	6-phospho-beta-galactosidase activity
Q5A_RS02455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS02455	COG1263	PTS System
Q5A_RS02460	COG1609	Transcriptional regulator
Q5A_RS02475	COG0523	cobalamin synthesis protein
Q5A_RS02480	COG2879	small protein
Q5A_RS02485	COG1966	Carbon starvation protein
Q5A_RS02500	COG0174	glutamine synthetase
Q5A_RS02510	COG3391	amine dehydrogenase activity
Q5A_RS02520	COG2207	Transcriptional regulator
Q5A_RS02525	COG3708	Transcriptional regulator
Q5A_RS02525	COG2207	Transcriptional regulator
Q5A_RS02530	COG1376	ErfK ybiS ycfS ynhG family protein
Q5A_RS02535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Q5A_RS02560	COG0811	peptide transport
Q5A_RS02570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Q5A_RS02575	COG1454	alcohol dehydrogenase
Q5A_RS02580	COG2267	carboxylic ester hydrolase activity
Q5A_RS02585	COG1846	Transcriptional regulator
Q5A_RS02595	COG0179	Fumarylacetoacetate (FAA) hydrolase
Q5A_RS02600	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS02615	COG3971	2-oxopent-4-enoate hydratase activity
Q5A_RS02635	COG2368	4-hydroxyphenylacetate
Q5A_RS02640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Q5A_RS02645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Q5A_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS02665	COG4948	Mandelate Racemase Muconate Lactonizing
Q5A_RS02670	COG3618	amidohydrolase
Q5A_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS02680	COG3254	rhamnose metabolic process
Q5A_RS02685	COG0738	Major facilitator superfamily
Q5A_RS02690	COG2814	Major facilitator Superfamily
Q5A_RS02705	COG1309	transcriptional regulator
Q5A_RS02710	COG3706	GGDEF domain
Q5A_RS02740	COG0667	Aldo Keto reductase
Q5A_RS02745	COG2813	Specifically methylates the guanine in position
Q5A_RS02750	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
Q5A_RS02765	COG3550	peptidyl-serine autophosphorylation
Q5A_RS02770	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Q5A_RS02775	COG2823	Periplasmic or secreted lipoprotein
Q5A_RS02780	COG5487	UPF0391 membrane protein
Q5A_RS02785	COG3237	CsbD-like
Q5A_RS02790	COG4667	esterase of the alpha-beta hydrolase superfamily
Q5A_RS02795	COG0084	hydrolase, TatD family'
Q5A_RS02800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Q5A_RS02805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Q5A_RS02810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Q5A_RS02815	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Q5A_RS02825	COG3550	peptidyl-serine autophosphorylation
Q5A_RS02830	COG3726	membrane protein affecting hemolysin expression
Q5A_RS02835	COG0560	Phosphoserine phosphatase
Q5A_RS02850	COG0604	alcohol dehydrogenase
Q5A_RS02860	COG0488	(ABC) transporter
Q5A_RS02865	COG2885	chlorophyll binding
Q5A_RS02870	COG2199	diguanylate cyclase activity
Q5A_RS02880	COG0741	lytic transglycosylase activity
Q5A_RS02885	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
Q5A_RS02890	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Q5A_RS02895	COG0406	alpha-ribazole phosphatase activity
Q5A_RS02900	COG2207	Transcriptional regulator
Q5A_RS02900	COG3708	Transcriptional regulator
Q5A_RS02905	COG3045	CreA protein
Q5A_RS02910	COG0745	RESPONSE REGULATOR receiver
Q5A_RS02925	COG0083	homoserine kinase activity
Q5A_RS02935	COG3022	response to hydroperoxide
Q5A_RS02940	COG1115	amino acid carrier protein
Q5A_RS02945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Q5A_RS02950	COG0521	Mo-molybdopterin cofactor biosynthetic process
Q5A_RS02960	COG1584	GPR1 FUN34 yaaH family protein
Q5A_RS02965	COG0443	Heat shock 70 kDa protein
Q5A_RS02970	COG0484	heat shock protein binding
Q5A_RS02975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Q5A_RS02980	COG0583	DNA-binding transcription factor activity
Q5A_RS02985	COG0268	Binds directly to 16S ribosomal RNA
Q5A_RS02990	COG0196	riboflavin kinase activity
Q5A_RS02995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Q5A_RS03000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Q5A_RS03005	COG1047	Peptidyl-prolyl cis-trans
Q5A_RS03010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Q5A_RS03035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Q5A_RS03045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Q5A_RS03055	COG0475	glutathione-regulated potassium exporter activity
Q5A_RS03055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Q5A_RS03065	COG2966	Psort location CytoplasmicMembrane, score
Q5A_RS03075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Q5A_RS03085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Q5A_RS03090	COG2967	ApaG domain
Q5A_RS03095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Q5A_RS03100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Q5A_RS03110	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Q5A_RS03120	COG0564	pseudouridine synthase activity
Q5A_RS03125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Q5A_RS03130	COG0417	DNA replication proofreading
Q5A_RS03135	COG0586	Pfam SNARE associated Golgi protein
Q5A_RS03140	COG0440	acetolactate synthase activity
Q5A_RS03145	COG0028	Belongs to the TPP enzyme family
Q5A_RS03155	COG1178	ABC-type Fe3 transport system permease component
Q5A_RS03160	COG4143	(ABC) transporter
Q5A_RS03170	COG2814	Major facilitator Superfamily
Q5A_RS03175	COG0471	metal ion transport
Q5A_RS03180	COG0066	3-isopropylmalate dehydratase activity
Q5A_RS03185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Q5A_RS03190	COG0473	3-isopropylmalate dehydrogenase activity
Q5A_RS03195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Q5A_RS03205	COG1022	Amp-dependent synthetase and ligase
Q5A_RS03210	COG0028	Belongs to the TPP enzyme family
Q5A_RS03230	COG2001	Belongs to the MraZ family
Q5A_RS03235	COG0275	rRNA processing
Q5A_RS03240	COG3116	cell division
Q5A_RS03245	COG0768	penicillin binding
Q5A_RS03250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Q5A_RS03255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Q5A_RS03260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Q5A_RS03270	COG0772	Belongs to the SEDS family
Q5A_RS03275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Q5A_RS03280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Q5A_RS03285	COG1181	Belongs to the D-alanine--D-alanine ligase family
Q5A_RS03290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Q5A_RS03295	COG0849	cell division
Q5A_RS03300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Q5A_RS03320	COG0653	protein targeting
Q5A_RS03325	COG0494	nUDIX hydrolase
Q5A_RS03330	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Q5A_RS03335	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Q5A_RS03340	COG0237	dephospho-CoA kinase activity
Q5A_RS03345	COG0516	GMP reductase activity
Q5A_RS03350	COG1459	type II secretion system
Q5A_RS03355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Q5A_RS03360	COG4969	Belongs to the N-Me-Phe pilin family
Q5A_RS03370	COG3023	N-Acetylmuramoyl-L-alanine amidase
Q5A_RS03375	COG3725	Membrane protein required for beta-lactamase induction
Q5A_RS03380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Q5A_RS03390	COG0316	Belongs to the HesB IscA family
Q5A_RS03395	COG2860	membrane
Q5A_RS03405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Q5A_RS03410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Q5A_RS03420	COG3835	regulator
Q5A_RS03425	COG2721	sulfolactate sulfo-lyase activity
Q5A_RS03430	COG2271	Major facilitator Superfamily
Q5A_RS03435	COG4948	Mandelate Racemase Muconate Lactonizing
Q5A_RS03440	COG4948	Mandelate Racemase Muconate Lactonizing
Q5A_RS03445	COG3836	Belongs to the HpcH HpaI aldolase family
Q5A_RS03450	COG2084	Dehydrogenase
Q5A_RS03455	COG1929	Belongs to the glycerate kinase type-1 family
Q5A_RS03465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Q5A_RS03470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Q5A_RS03475	COG3956	TIGRFAM MazG family protein
Q5A_RS03485	COG0504	CTP synthase activity
Q5A_RS03515	COG2986	histidine ammonia-lyase
Q5A_RS03520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Q5A_RS03525	COG2271	Major facilitator Superfamily
Q5A_RS03530	COG0602	queuosine metabolic process
Q5A_RS03540	COG0720	synthase
Q5A_RS03545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Q5A_RS03550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Q5A_RS03555	COG0175	sulfate reduction
Q5A_RS03560	COG2234	aminopeptidase activity
Q5A_RS03565	COG1648	precorrin-2 dehydrogenase activity
Q5A_RS03565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Q5A_RS03570	COG0175	sulfate reduction
Q5A_RS03575	COG2895	sulfate adenylyltransferase (ATP) activity
Q5A_RS03580	COG0529	Catalyzes the synthesis of activated sulfate
Q5A_RS03590	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Q5A_RS03595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Q5A_RS03600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Q5A_RS03605	COG0585	pseudouridine synthase activity
Q5A_RS03610	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Q5A_RS03615	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Q5A_RS03620	COG4942	peptidase
Q5A_RS03620	COG1388	LysM domain
Q5A_RS03625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Q5A_RS03630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Q5A_RS03635	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Q5A_RS03640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Q5A_RS03645	COG2723	6-phospho-beta-galactosidase activity
Q5A_RS03650	COG1917	Cupin 2, conserved barrel domain protein
Q5A_RS03650	COG2169	Transcriptional regulator
Q5A_RS03670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Q5A_RS03675	COG2137	regulation of response to DNA damage stimulus
Q5A_RS03680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Q5A_RS03685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Q5A_RS03715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Q5A_RS03720	COG1238	metal cluster binding
Q5A_RS03725	COG2918	glutathione biosynthetic process
Q5A_RS03730	COG1854	S-ribosylhomocysteine lyase activity
Q5A_RS03735	COG4536	flavin adenine dinucleotide binding
Q5A_RS03740	COG4137	Cytochrome C assembly protein
Q5A_RS03745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Q5A_RS03750	COG0228	four-way junction DNA binding
Q5A_RS03755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Q5A_RS03760	COG0336	Belongs to the RNA methyltransferase TrmD family
Q5A_RS03765	COG0335	large ribosomal subunit rRNA binding
Q5A_RS03875	COG3137	Salt-induced outer membrane protein
Q5A_RS03880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Q5A_RS03885	COG0287	Prephenate dehydrogenase
Q5A_RS03885	COG1605	Chorismate mutase
Q5A_RS03890	COG0077	Prephenate dehydratase
Q5A_RS03890	COG1605	Chorismate mutase
Q5A_RS03895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Q5A_RS03900	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Q5A_RS03905	COG0564	pseudouridine synthase activity
Q5A_RS03915	COG0542	response to heat
Q5A_RS03965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Q5A_RS03975	COG4221	oxidoreductase activity
Q5A_RS03975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Q5A_RS03975	COG3321	synthase
Q5A_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS03980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Q5A_RS04010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Q5A_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS04030	COG0656	L-ascorbic acid biosynthetic process
Q5A_RS04035	COG0583	DNA-binding transcription factor activity
Q5A_RS04040	COG2814	Major facilitator Superfamily
Q5A_RS04050	COG0741	lytic transglycosylase activity
Q5A_RS04050	COG1388	LysM domain
Q5A_RS04055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Q5A_RS04060	COG2226	methyltransferase
Q5A_RS04065	COG0328	RNA-DNA hybrid ribonuclease activity
Q5A_RS04070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Q5A_RS04080	COG1953	Uracil, thiamine, allantoin
Q5A_RS04175	COG0765	amino acid transport
Q5A_RS04180	COG1126	abc transporter atp-binding protein
Q5A_RS04185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Q5A_RS04200	COG2351	hydroxyisourate hydrolase activity
Q5A_RS04205	COG2233	PERMEase
Q5A_RS04215	COG0436	Aminotransferase
Q5A_RS04220	COG0235	Class ii aldolase
Q5A_RS04225	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Q5A_RS04230	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Q5A_RS04235	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Q5A_RS04240	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
Q5A_RS04255	COG1960	acyl-CoA dehydrogenase activity
Q5A_RS04260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Q5A_RS04265	COG0121	glutamine amidotransferase
Q5A_RS04270	COG3034	peptidoglycan biosynthetic process
Q5A_RS04275	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Q5A_RS04280	COG1805	sodium ion transport
Q5A_RS04285	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Q5A_RS04290	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Q5A_RS04295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Q5A_RS04300	COG2871	sodium ion transport
Q5A_RS04305	COG1477	protein flavinylation
Q5A_RS04310	COG2991	Protein conserved in bacteria
Q5A_RS04315	COG0584	glycerophosphoryl diester phosphodiesterase
Q5A_RS04320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Q5A_RS04335	COG2195	Cleaves the N-terminal amino acid of tripeptides
Q5A_RS04340	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Q5A_RS04345	COG1073	alpha beta
Q5A_RS04355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Q5A_RS04380	COG3038	cytochrome b561
Q5A_RS04385	COG0747	negative chemotaxis
Q5A_RS04395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Q5A_RS04395	COG3433	isochorismatase activity
Q5A_RS04395	COG2226	methyltransferase
Q5A_RS04400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Q5A_RS04405	COG4774	siderophore transport
Q5A_RS04405	COG1629	transport
Q5A_RS04410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Q5A_RS04415	COG3391	amine dehydrogenase activity
Q5A_RS04430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Q5A_RS04435	COG2207	Transcriptional regulator
Q5A_RS04440	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS04475	COG0583	DNA-binding transcription factor activity
Q5A_RS04480	COG3961	Belongs to the TPP enzyme family
Q5A_RS04505	COG1349	DNA-binding transcription factor activity
Q5A_RS04510	COG0346	lactoylglutathione lyase activity
Q5A_RS04525	COG1335	isochorismatase
Q5A_RS04540	COG3011	Protein conserved in bacteria
Q5A_RS04555	COG3416	Protein conserved in bacteria
Q5A_RS04565	COG2226	methyltransferase
Q5A_RS04610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Q5A_RS04615	COG0667	Aldo Keto reductase
Q5A_RS04640	COG3123	guanosine phosphorylase activity
Q5A_RS04650	COG2974	May be involved in recombination
Q5A_RS04660	COG1129	ABC transporter
Q5A_RS04665	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS04680	COG0191	fructose-bisphosphate aldolase activity
Q5A_RS04695	COG1940	carbohydrate kinase activity
Q5A_RS04715	COG0419	ATPase involved in DNA repair
Q5A_RS04720	COG0420	3'-5' exonuclease activity
Q5A_RS04725	COG0745	RESPONSE REGULATOR receiver
Q5A_RS04730	COG5002	protein histidine kinase activity
Q5A_RS04740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Q5A_RS04755	COG3093	addiction module antidote protein HigA
Q5A_RS04770	COG0668	transmembrane transport
Q5A_RS04775	COG0366	Alpha amylase catalytic
Q5A_RS04785	COG0450	alkyl hydroperoxide reductase
Q5A_RS04790	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
Q5A_RS04795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Q5A_RS04800	COG0343	queuine tRNA-ribosyltransferase activity
Q5A_RS04805	COG1862	Preprotein translocase
Q5A_RS04815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Q5A_RS04825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Q5A_RS04830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Q5A_RS04830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Q5A_RS04835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Q5A_RS04840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Q5A_RS04845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Q5A_RS04850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Q5A_RS04855	COG0667	Aldo Keto reductase
Q5A_RS04860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Q5A_RS04865	COG0142	geranyltranstransferase activity
Q5A_RS04870	COG1722	exodeoxyribonuclease VII activity
Q5A_RS04875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Q5A_RS04875	COG0301	tRNA thio-modification
Q5A_RS04885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Q5A_RS04890	COG1666	GTP binding
Q5A_RS04895	COG2814	Major facilitator Superfamily
Q5A_RS04900	COG0109	protoheme IX farnesyltransferase activity
Q5A_RS04905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Q5A_RS04910	COG1845	cytochrome c oxidase, subunit III
Q5A_RS04915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Q5A_RS04920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Q5A_RS04925	COG2223	nitrite transmembrane transporter activity
Q5A_RS04930	COG3056	Lipoprotein
Q5A_RS04935	COG0271	Belongs to the BolA IbaG family
Q5A_RS04940	COG0544	peptidyl-prolyl cis-trans isomerase activity
Q5A_RS04950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Q5A_RS04955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Q5A_RS04965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Q5A_RS04970	COG1555	photosystem II stabilization
Q5A_RS04975	COG0824	Thioesterase
Q5A_RS04980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Q5A_RS04985	COG4533	DNA binding
Q5A_RS04990	COG0561	phosphatase activity
Q5A_RS05000	COG1522	sequence-specific DNA binding
Q5A_RS05005	COG1132	(ABC) transporter
Q5A_RS05010	COG1132	(ABC) transporter
Q5A_RS05015	COG0347	Belongs to the P(II) protein family
Q5A_RS05020	COG0004	ammonium transporteR
Q5A_RS05025	COG1946	Acyl-CoA thioesterase
Q5A_RS05030	COG3126	Type III secretion system lipoprotein chaperone (YscW)
Q5A_RS05035	COG3695	enzyme binding
Q5A_RS05055	COG2249	NAD(P)H dehydrogenase (quinone) activity
Q5A_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS05105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Q5A_RS05125	COG2165	general secretion pathway protein
Q5A_RS05135	COG3156	type II secretion system protein K
Q5A_RS05160	COG3397	chitin binding
Q5A_RS05185	COG1121	(ABC) transporter
Q5A_RS05190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Q5A_RS05195	COG0803	Belongs to the bacterial solute-binding protein 9 family
Q5A_RS05200	COG0254	rRNA binding
Q5A_RS05205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Q5A_RS05210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS05215	COG1309	transcriptional regulator
Q5A_RS05220	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Q5A_RS05225	COG3264	Mechanosensitive ion channel
Q5A_RS05225	COG1196	nuclear chromosome segregation
Q5A_RS05240	COG2832	Protein of unknown function (DUF454)
Q5A_RS05245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Q5A_RS05250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Q5A_RS05260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Q5A_RS05265	COG0326	Molecular chaperone. Has ATPase activity
Q5A_RS05270	COG0563	adenylate kinase activity
Q5A_RS05275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Q5A_RS05280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Q5A_RS05285	COG4651	solute:proton antiporter activity
Q5A_RS05285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Q5A_RS05290	COG2223	nitrite transmembrane transporter activity
Q5A_RS05295	COG0737	Belongs to the 5'-nucleotidase family
Q5A_RS05300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Q5A_RS05305	COG3735	TraB family
Q5A_RS05310	COG2217	Heavy metal translocating P-type atpase
Q5A_RS05315	COG0789	Transcriptional regulator
Q5A_RS05325	COG1585	Membrane protein implicated in regulation of membrane protease activity
Q5A_RS05330	COG0330	HflC and HflK could
Q5A_RS05335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Q5A_RS05340	COG3118	belongs to the thioredoxin family
Q5A_RS05345	COG0300	oxidoreductase activity
Q5A_RS05350	COG2755	lipolytic protein G-D-S-L family
Q5A_RS05355	COG4181	ATPase activity
Q5A_RS05360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Q5A_RS05365	COG2814	Major facilitator Superfamily
Q5A_RS05380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Q5A_RS05385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Q5A_RS05390	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Q5A_RS05395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Q5A_RS05400	COG0215	cysteine-tRNA ligase activity
Q5A_RS05405	COG2501	S4 domain
Q5A_RS05410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Q5A_RS05435	COG1403	HNH endonuclease
Q5A_RS05445	COG0582	viral genome integration into host DNA
Q5A_RS05510	COG3188	usher protein
Q5A_RS05515	COG3121	Chaperone
Q5A_RS05565	COG4983	Phage plasmid primase, P4 family domain protein
Q5A_RS05580	COG3596	GTP binding
Q5A_RS05595	COG3453	Protein conserved in bacteria
Q5A_RS05595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Q5A_RS05610	COG2801	Transposase and inactivated derivatives
Q5A_RS05620	COG0545	Peptidyl-prolyl cis-trans isomerase
Q5A_RS05630	COG2197	response regulator
Q5A_RS05655	COG3188	usher protein
Q5A_RS05660	COG3121	Chaperone
Q5A_RS05665	COG3539	Fimbrial protein
Q5A_RS05680	COG3539	Fimbrial protein
Q5A_RS05685	COG3539	Fimbrial protein
Q5A_RS05700	COG4566	intracellular signal transduction
Q5A_RS05775	COG0384	phenazine biosynthesis protein PhzF
Q5A_RS05780	COG3423	Transcriptional regulator
Q5A_RS05800	COG0667	Aldo Keto reductase
Q5A_RS05805	COG0583	DNA-binding transcription factor activity
Q5A_RS05815	COG2199	diguanylate cyclase activity
Q5A_RS05820	COG1278	Cold shock
Q5A_RS05830	COG1126	abc transporter atp-binding protein
Q5A_RS05835	COG0765	amino acid transport
Q5A_RS05845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Q5A_RS05850	COG1473	amidohydrolase
Q5A_RS05860	COG2814	Major facilitator Superfamily
Q5A_RS05870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Q5A_RS05880	COG3706	GGDEF domain
Q5A_RS05890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Q5A_RS05895	COG0321	lipoyl(octanoyl) transferase activity
Q5A_RS05900	COG2921	Belongs to the UPF0250 family
Q5A_RS05905	COG1686	Belongs to the peptidase S11 family
Q5A_RS05910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Q5A_RS05915	COG0772	Belongs to the SEDS family
Q5A_RS05920	COG0768	penicillin binding
Q5A_RS05925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Q5A_RS05930	COG0799	negative regulation of ribosome biogenesis
Q5A_RS05935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Q5A_RS05940	COG1466	dna polymerase III delta subunit
Q5A_RS05945	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Q5A_RS05950	COG0495	leucyl-tRNA aminoacylation
Q5A_RS05955	COG2888	peptidyl-tyrosine sulfation
Q5A_RS05965	COG1957	nucleoside hydrolase
Q5A_RS05970	COG1126	abc transporter atp-binding protein
Q5A_RS05975	COG0765	amino acid transport
Q5A_RS05980	COG0765	amino acid transport
Q5A_RS05990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Q5A_RS05995	COG4535	Mg2 and Co2 transporter CorC
Q5A_RS06000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Q5A_RS06005	COG1702	phosphate starvation-inducible protein PhoH
Q5A_RS06010	COG2824	Alkylphosphonate utilization operon protein PhnA
Q5A_RS06015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Q5A_RS06020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Q5A_RS06055	COG0367	asparagine synthase
Q5A_RS06060	COG3469	chitinase activity
Q5A_RS06065	COG0647	UMP catabolic process
Q5A_RS06070	COG1846	Transcriptional regulator
Q5A_RS06070	COG1940	carbohydrate kinase activity
Q5A_RS06075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Q5A_RS06080	COG0363	glucosamine-6-phosphate deaminase activity
Q5A_RS06085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS06085	COG2190	(PTS) system
Q5A_RS06085	COG1263	PTS System
Q5A_RS06090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Q5A_RS06110	COG2814	Major facilitator Superfamily
Q5A_RS06125	COG0735	belongs to the Fur family
Q5A_RS06140	COG0596	Alpha beta hydrolase
Q5A_RS06145	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Q5A_RS06150	COG0033	Phosphoglucomutase
Q5A_RS06155	COG1695	Transcriptional regulator
Q5A_RS06165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Q5A_RS06165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Q5A_RS06170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Q5A_RS06175	COG0745	RESPONSE REGULATOR receiver
Q5A_RS06180	COG2205	protein histidine kinase activity
Q5A_RS06185	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Q5A_RS06190	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Q5A_RS06195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Q5A_RS06210	COG3272	Protein of unknown function (DUF1722)
Q5A_RS06220	COG5212	phosphodiesterase
Q5A_RS06225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Q5A_RS06230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Q5A_RS06235	COG1984	allophanate hydrolase subunit 2
Q5A_RS06240	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Q5A_RS06260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Q5A_RS06275	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Q5A_RS06285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Q5A_RS06290	COG0567	Dehydrogenase, E1 component
Q5A_RS06295	COG0508	dehydrogenase complex catalyzes the overall conversion of
Q5A_RS06300	COG0045	succinate-CoA ligase (ADP-forming) activity
Q5A_RS06305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Q5A_RS06310	COG0737	Belongs to the 5'-nucleotidase family
Q5A_RS06315	COG1271	oxidase subunit
Q5A_RS06320	COG1294	oxidase, subunit
Q5A_RS06325	COG4890	Cyd operon protein YbgT
Q5A_RS06330	COG3790	cyd operon protein YbgE
Q5A_RS06335	COG0824	Thioesterase
Q5A_RS06340	COG0811	peptide transport
Q5A_RS06345	COG0848	biopolymer transport protein
Q5A_RS06350	COG3064	Membrane
Q5A_RS06355	COG0823	Involved in the tonB-independent uptake of proteins
Q5A_RS06360	COG2885	chlorophyll binding
Q5A_RS06365	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Q5A_RS06410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Q5A_RS06420	COG1230	cation diffusion facilitator family transporter
Q5A_RS06425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS06425	COG2205	protein histidine kinase activity
Q5A_RS06430	COG2197	response regulator
Q5A_RS06435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Q5A_RS06440	COG0588	phosphoglycerate mutase activity
Q5A_RS06450	COG2017	converts alpha-aldose to the beta-anomer
Q5A_RS06455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Q5A_RS06460	COG1085	galactose-1-phosphate uridylyltransferase
Q5A_RS06475	COG1119	ATPase activity
Q5A_RS06480	COG3585	molybdate ion transport
Q5A_RS06480	COG2005	Transcriptional regulator
Q5A_RS06490	COG0725	ABC transporter, periplasmic molybdate-binding protein
Q5A_RS06495	COG4149	molybdate abc transporter
Q5A_RS06505	COG0561	phosphatase activity
Q5A_RS06510	COG2706	6-phosphogluconolactonase activity
Q5A_RS06530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Q5A_RS06535	COG0156	8-amino-7-oxononanoate synthase activity
Q5A_RS06555	COG0556	nucleotide-excision repair
Q5A_RS06560	COG4628	conserved protein (DUF2132)
Q5A_RS06565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Q5A_RS06570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Q5A_RS06575	COG0521	Mo-molybdopterin cofactor biosynthetic process
Q5A_RS06580	COG0315	cyclic pyranopterin monophosphate synthase activity
Q5A_RS06585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Q5A_RS06590	COG0314	molybdopterin synthase activity
Q5A_RS06595	COG0670	Belongs to the BI1 family
Q5A_RS06600	COG0842	Transport permease protein
Q5A_RS06605	COG0842	Transport permease protein
Q5A_RS06610	COG1131	(ABC) transporter
Q5A_RS06615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS06620	COG1309	transcriptional regulator
Q5A_RS06625	COG0513	Belongs to the DEAD box helicase family
Q5A_RS06630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Q5A_RS06635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Q5A_RS06670	COG0583	DNA-binding transcription factor activity
Q5A_RS06690	COG0583	DNA-binding transcription factor activity
Q5A_RS06695	COG1280	lysine exporter protein (LysE YggA)
Q5A_RS06700	COG0586	Pfam SNARE associated Golgi protein
Q5A_RS06705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Q5A_RS06710	COG1686	Belongs to the peptidase S11 family
Q5A_RS06735	COG2354	Protein conserved in bacteria
Q5A_RS06745	COG0697	spore germination
Q5A_RS06760	COG1464	Belongs to the NlpA lipoprotein family
Q5A_RS06785	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS06790	COG0277	FAD linked oxidase domain protein
Q5A_RS06805	COG1181	Belongs to the D-alanine--D-alanine ligase family
Q5A_RS06820	COG0436	Aminotransferase
Q5A_RS06830	COG1472	Belongs to the glycosyl hydrolase 3 family
Q5A_RS06835	COG2267	carboxylic ester hydrolase activity
Q5A_RS06850	COG1192	Involved in chromosome partitioning
Q5A_RS06870	COG0583	DNA-binding transcription factor activity
Q5A_RS06875	COG2814	Major facilitator Superfamily
Q5A_RS06880	COG1070	Carbohydrate kinase
Q5A_RS06885	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Q5A_RS06910	COG0366	Alpha amylase catalytic
Q5A_RS06930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Q5A_RS06945	COG1309	transcriptional regulator
Q5A_RS06950	COG1464	Belongs to the NlpA lipoprotein family
Q5A_RS06955	COG2011	ABC-type metal ion transport system permease component
Q5A_RS06960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Q5A_RS06970	COG0583	DNA-binding transcription factor activity
Q5A_RS06975	COG0604	alcohol dehydrogenase
Q5A_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS06975	COG3321	synthase
Q5A_RS07000	COG2378	regulation of single-species biofilm formation
Q5A_RS07005	COG2271	Major facilitator Superfamily
Q5A_RS07010	COG1802	Transcriptional regulator
Q5A_RS07015	COG1063	alcohol dehydrogenase
Q5A_RS07025	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Q5A_RS07035	COG3639	organic phosphonate transmembrane transporter activity
Q5A_RS07040	COG4807	Protein conserved in bacteria
Q5A_RS07055	COG1802	Transcriptional regulator
Q5A_RS07075	COG1129	ABC transporter
Q5A_RS07085	COG3511	phospholipase C
Q5A_RS07095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Q5A_RS07105	COG0583	DNA-binding transcription factor activity
Q5A_RS07110	COG2897	thiosulfate sulfurtransferase activity
Q5A_RS07120	COG1683	Conserved Protein
Q5A_RS07135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Q5A_RS07145	COG0625	glutathione transferase activity
Q5A_RS07160	COG1335	isochorismatase
Q5A_RS07165	COG0583	DNA-binding transcription factor activity
Q5A_RS07180	COG1732	Glycine betaine
Q5A_RS07185	COG1174	glycine betaine transport
Q5A_RS07190	COG1125	glycine betaine transport
Q5A_RS07195	COG1174	glycine betaine transport
Q5A_RS07200	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Q5A_RS07210	COG0583	DNA-binding transcription factor activity
Q5A_RS07215	COG0697	spore germination
Q5A_RS07265	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
Q5A_RS07280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Q5A_RS07285	COG1942	4-Oxalocrotonate Tautomerase
Q5A_RS07295	COG1522	sequence-specific DNA binding
Q5A_RS07300	COG0697	spore germination
Q5A_RS07305	COG1280	lysine exporter protein (LysE YggA)
Q5A_RS07315	COG0477	Major facilitator Superfamily
Q5A_RS07325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Q5A_RS07340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Q5A_RS07345	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
Q5A_RS07370	COG1126	abc transporter atp-binding protein
Q5A_RS07375	COG0765	amino acid transport
Q5A_RS07380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS07385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Q5A_RS07400	COG2731	YhcH YjgK YiaL family protein
Q5A_RS07410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Q5A_RS07415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Q5A_RS07420	COG0583	DNA-binding transcription factor activity
Q5A_RS07430	COG3622	Belongs to the hyi family
Q5A_RS07440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Q5A_RS07445	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Q5A_RS07455	COG5002	protein histidine kinase activity
Q5A_RS07460	COG0745	RESPONSE REGULATOR receiver
Q5A_RS07465	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Q5A_RS07470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Q5A_RS07480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Q5A_RS07485	COG1309	transcriptional regulator
Q5A_RS07490	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS07495	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Q5A_RS07500	COG0069	glutamate synthase activity
Q5A_RS07510	COG2200	EAL domain
Q5A_RS07515	COG3539	Fimbrial protein
Q5A_RS07535	COG3708	Transcriptional regulator
Q5A_RS07535	COG2207	Transcriptional regulator
Q5A_RS07540	COG0579	oxidoreductase
Q5A_RS07545	COG0702	epimerase
Q5A_RS07560	COG0625	glutathione transferase activity
Q5A_RS07565	COG0640	Transcriptional regulator
Q5A_RS07585	COG0488	(ABC) transporter
Q5A_RS07595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Q5A_RS07600	COG0303	'Molybdopterin
Q5A_RS07610	COG1446	asparaginase
Q5A_RS07615	COG4172	Belongs to the ABC transporter superfamily
Q5A_RS07620	COG0747	negative chemotaxis
Q5A_RS07625	COG0601	transmembrane transport
Q5A_RS07630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Q5A_RS07655	COG0583	DNA-binding transcription factor activity
Q5A_RS07660	COG0477	Major facilitator Superfamily
Q5A_RS07665	COG0302	gtp cyclohydrolase
Q5A_RS07670	COG2311	Membrane
Q5A_RS07675	COG1609	Transcriptional regulator
Q5A_RS07695	COG2949	membrane
Q5A_RS07700	COG0281	malic enzyme
Q5A_RS07705	COG0295	cytidine deaminase activity
Q5A_RS07710	COG1346	cytolysis
Q5A_RS07715	COG1380	Effector of murein hydrolase LrgA
Q5A_RS07720	COG2814	Major facilitator Superfamily
Q5A_RS07735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Q5A_RS07735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Q5A_RS07740	COG0489	protein tyrosine kinase activity
Q5A_RS07750	COG0572	uridine kinase
Q5A_RS07755	COG0717	Belongs to the dCTP deaminase family
Q5A_RS07760	COG2982	Protein involved in outer membrane biogenesis
Q5A_RS07765	COG3069	C4-dicarboxylate transmembrane transporter activity
Q5A_RS07770	COG1253	flavin adenine dinucleotide binding
Q5A_RS07775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Q5A_RS07780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Q5A_RS07810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Q5A_RS07815	COG0489	protein tyrosine kinase activity
Q5A_RS07815	COG3206	protein involved in exopolysaccharide biosynthesis
Q5A_RS07865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Q5A_RS07905	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Q5A_RS07925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Q5A_RS07930	COG0140	phosphoribosyl-ATP diphosphatase activity
Q5A_RS07930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Q5A_RS07935	COG0107	imidazoleglycerol-phosphate synthase activity
Q5A_RS07940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Q5A_RS07955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Q5A_RS07965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Q5A_RS07970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Q5A_RS07990	COG0598	Magnesium transport protein CorA
Q5A_RS08000	COG2133	pyrroloquinoline quinone binding
Q5A_RS08005	COG0625	glutathione transferase activity
Q5A_RS08020	COG0626	cystathionine gamma-synthase activity
Q5A_RS08030	COG1686	Belongs to the peptidase S11 family
Q5A_RS08035	COG1760	l-serine dehydratase
Q5A_RS08040	COG0814	amino acid
Q5A_RS08045	COG1349	DNA-binding transcription factor activity
Q5A_RS08050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Q5A_RS08060	COG0671	phosphoesterase, PA-phosphatase related
Q5A_RS08075	COG4574	serine-type endopeptidase inhibitor activity
Q5A_RS08080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Q5A_RS08085	COG0569	domain protein
Q5A_RS08085	COG2985	domain, Protein
Q5A_RS08105	COG0189	ligase activity
Q5A_RS08115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Q5A_RS08120	COG3842	ATPase activity
Q5A_RS08125	COG1176	ABC-type spermidine putrescine transport system, permease component I
Q5A_RS08130	COG1177	transmembrane transport
Q5A_RS08140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Q5A_RS08145	COG2026	Addiction module toxin, RelE StbE family
Q5A_RS08155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS08160	COG4160	amino acid transport
Q5A_RS08165	COG4215	(ABC) transporter
Q5A_RS08170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS08175	COG1126	abc transporter atp-binding protein
Q5A_RS08185	COG0393	Putative heavy-metal-binding
Q5A_RS08190	COG3023	N-Acetylmuramoyl-L-alanine amidase
Q5A_RS08195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Q5A_RS08200	COG0702	epimerase
Q5A_RS08210	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Q5A_RS08215	COG0028	Belongs to the TPP enzyme family
Q5A_RS08220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Q5A_RS08225	COG1151	hydroxylamine reductase activity
Q5A_RS08230	COG2431	L-lysine efflux transmembrane transporter activity
Q5A_RS08235	COG3593	DNA synthesis involved in DNA repair
Q5A_RS08240	COG2990	Protein conserved in bacteria
Q5A_RS08245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS08255	COG1278	Cold shock
Q5A_RS08260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Q5A_RS08265	COG0542	response to heat
Q5A_RS08270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Q5A_RS08275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Q5A_RS08280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Q5A_RS08295	COG0583	DNA-binding transcription factor activity
Q5A_RS08300	COG0492	ferredoxin-NADP+ reductase activity
Q5A_RS08310	COG3107	peptidoglycan biosynthetic process
Q5A_RS08310	COG1674	ftsk spoiiie
Q5A_RS08315	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Q5A_RS08320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Q5A_RS08325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Q5A_RS08350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Q5A_RS08355	COG1882	Formate acetyltransferase
Q5A_RS08360	COG2116	formate transmembrane transporter activity
Q5A_RS08365	COG1944	ATP diphosphatase activity
Q5A_RS08405	COG0252	asparaginase activity
Q5A_RS08410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Q5A_RS08415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Q5A_RS08420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Q5A_RS08425	COG0539	negative regulation of cytoplasmic translation
Q5A_RS08430	COG0776	regulation of translation
Q5A_RS08435	COG2333	competence protein COMEC
Q5A_RS08435	COG0658	competence protein
Q5A_RS08445	COG1663	tetraacyldisaccharide 4'-kinase activity
Q5A_RS08450	COG5383	Protein conserved in bacteria
Q5A_RS08460	COG1278	Cold shock
Q5A_RS08465	COG3214	Protein conserved in bacteria
Q5A_RS08470	COG2835	tetraacyldisaccharide 4'-kinase activity
Q5A_RS08475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Q5A_RS08480	COG3173	Aminoglycoside phosphotransferase
Q5A_RS08485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Q5A_RS08490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Q5A_RS08495	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
Q5A_RS08505	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Q5A_RS08515	COG2989	Protein conserved in bacteria
Q5A_RS08520	COG3108	Peptidase M15
Q5A_RS08525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Q5A_RS08530	COG1448	Aminotransferase
Q5A_RS08540	COG0017	Asparaginyl-tRNA synthetase
Q5A_RS08545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Q5A_RS08550	COG3706	GGDEF domain
Q5A_RS08555	COG0308	aminopeptidase N
Q5A_RS08565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Q5A_RS08570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Q5A_RS08575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Q5A_RS08580	COG0431	NADPH-dependent FMN reductase
Q5A_RS08585	COG0167	dihydroorotate dehydrogenase activity
Q5A_RS08595	COG3217	Mosc domain protein beta barrel domain protein
Q5A_RS08595	COG0633	Ferredoxin
Q5A_RS08600	COG0116	Belongs to the methyltransferase superfamily
Q5A_RS08600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Q5A_RS08605	COG0488	(ABC) transporter
Q5A_RS08610	COG2995	paraquat-inducible protein a
Q5A_RS08615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Q5A_RS08615	COG3008	intermembrane lipid transfer
Q5A_RS08620	COG3009	Protein conserved in bacteria
Q5A_RS08625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Q5A_RS08635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Q5A_RS08640	COG1067	ATP-dependent peptidase activity
Q5A_RS08645	COG3120	sequence-specific DNA binding
Q5A_RS08655	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Q5A_RS08660	COG3070	regulator of competence-specific genes
Q5A_RS08665	COG1289	transmembrane transporter activity
Q5A_RS08670	COG3304	Inner membrane component domain
Q5A_RS08675	COG0210	DNA helicase
Q5A_RS08680	COG1803	Methylglyoxal synthase
Q5A_RS08690	COG1832	CoA-binding protein
Q5A_RS08695	COG3785	DNA binding
Q5A_RS08700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Q5A_RS08705	COG1254	Belongs to the acylphosphatase family
Q5A_RS08710	COG2920	part of a sulfur-relay system
Q5A_RS08715	COG0670	Belongs to the BI1 family
Q5A_RS08745	COG2885	chlorophyll binding
Q5A_RS08775	COG3501	Rhs element vgr protein
Q5A_RS08880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Q5A_RS08890	COG0655	NAD(P)H dehydrogenase (quinone) activity
Q5A_RS08895	COG1280	lysine exporter protein (LysE YggA)
Q5A_RS08915	COG2233	PERMEase
Q5A_RS08920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Q5A_RS08925	COG2267	carboxylic ester hydrolase activity
Q5A_RS08930	COG0251	oxidation-reduction process
Q5A_RS08935	COG1335	isochorismatase
Q5A_RS08940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Q5A_RS08945	COG1309	transcriptional regulator
Q5A_RS08950	COG1113	amino acid transport
Q5A_RS08970	COG1024	Enoyl-CoA hydratase
Q5A_RS08975	COG2814	Major facilitator Superfamily
Q5A_RS08980	COG0156	8-amino-7-oxononanoate synthase activity
Q5A_RS08985	COG2197	response regulator
Q5A_RS08990	COG0589	response to stress
Q5A_RS09000	COG0531	amino acid
Q5A_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS09010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Q5A_RS09025	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Q5A_RS09025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Q5A_RS09055	COG3136	membrane protein required for alginate biosynthesis
Q5A_RS09065	COG2197	response regulator
Q5A_RS09070	COG0322	excinuclease ABC activity
Q5A_RS09105	COG0477	Major facilitator Superfamily
Q5A_RS09120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS09125	COG0322	excinuclease ABC activity
Q5A_RS09160	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Q5A_RS09165	COG2943	transferase activity, transferring hexosyl groups
Q5A_RS09170	COG5645	(Lipo)protein
Q5A_RS09185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Q5A_RS09195	COG0640	Transcriptional regulator
Q5A_RS09210	COG0346	lactoylglutathione lyase activity
Q5A_RS09220	COG2814	Major facilitator Superfamily
Q5A_RS09230	COG1560	Kdo2-lipid A biosynthetic process
Q5A_RS09240	COG1902	pentaerythritol trinitrate reductase activity
Q5A_RS09245	COG1054	Belongs to the UPF0176 family
Q5A_RS09250	COG2353	YceI-like domain
Q5A_RS09255	COG3038	cytochrome b561
Q5A_RS09290	COG0418	dihydroorotase activity
Q5A_RS09295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Q5A_RS09300	COG1530	ribonuclease E activity
Q5A_RS09305	COG0564	pseudouridine synthase activity
Q5A_RS09315	COG1399	metal-binding, possibly nucleic acid-binding protein
Q5A_RS09320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Q5A_RS09325	COG0416	fatty acid biosynthetic process
Q5A_RS09330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Q5A_RS09335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Q5A_RS09345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Q5A_RS09350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Q5A_RS09360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Q5A_RS09365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Q5A_RS09370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Q5A_RS09375	COG0470	DNA polymerase III
Q5A_RS09380	COG0084	hydrolase, TatD family'
Q5A_RS09385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS09385	COG1263	PTS System
Q5A_RS09465	COG1321	iron dependent repressor
Q5A_RS09470	COG1914	H( )-stimulated, divalent metal cation uptake system
Q5A_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS09480	COG1733	regulation of RNA biosynthetic process
Q5A_RS09490	COG0537	adenosine 5'-monophosphoramidase activity
Q5A_RS09495	COG5633	Lipoprotein
Q5A_RS09500	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
Q5A_RS09505	COG0510	thiamine kinase activity
Q5A_RS09515	COG3150	esterase
Q5A_RS09520	COG1252	NADH dehydrogenase
Q5A_RS09525	COG3134	Outer membrane lipoprotein
Q5A_RS09540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS09545	COG3708	Transcriptional regulator
Q5A_RS09545	COG2207	Transcriptional regulator
Q5A_RS09585	COG2801	Transposase and inactivated derivatives
Q5A_RS09595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Q5A_RS09600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Q5A_RS09605	COG3381	protein complex oligomerization
Q5A_RS09610	COG2979	Protein of unknown function (DUF533)
Q5A_RS09615	COG1770	oligopeptidase
Q5A_RS09620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Q5A_RS09625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Q5A_RS09645	COG1528	Iron-storage protein
Q5A_RS09650	COG2372	response to copper ion
Q5A_RS09655	COG1276	copper resistance
Q5A_RS09700	COG2801	Transposase and inactivated derivatives
Q5A_RS09715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Q5A_RS09725	COG3655	Transcriptional regulator
Q5A_RS09745	COG4565	transcriptional regulatory protein
Q5A_RS09750	COG3290	protein histidine kinase activity
Q5A_RS09765	COG1129	ABC transporter
Q5A_RS09770	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS09780	COG1464	Belongs to the NlpA lipoprotein family
Q5A_RS09790	COG0589	response to stress
Q5A_RS09805	COG0740	serine-type endopeptidase activity
Q5A_RS09810	COG2184	nucleotidyltransferase activity
Q5A_RS09835	COG0012	GTP binding
Q5A_RS09840	COG0659	secondary active sulfate transmembrane transporter activity
Q5A_RS09845	COG0193	aminoacyl-tRNA hydrolase activity
Q5A_RS09855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Q5A_RS09860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Q5A_RS09865	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Q5A_RS09875	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Q5A_RS09880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Q5A_RS09885	COG2890	protein-(glutamine-N5) methyltransferase activity
Q5A_RS09900	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Q5A_RS09905	COG0659	secondary active sulfate transmembrane transporter activity
Q5A_RS09910	COG4702	Belongs to the UPF0303 family
Q5A_RS09915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Q5A_RS09930	COG4591	ABC-type transport system involved in lipoprotein release permease component
Q5A_RS09940	COG4591	ABC-type transport system involved in lipoprotein release permease component
Q5A_RS09960	COG1486	melibiose metabolic process
Q5A_RS09965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS09965	COG1263	PTS System
Q5A_RS09970	COG2195	Cleaves the N-terminal amino acid of tripeptides
Q5A_RS09975	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Q5A_RS09980	COG2850	peptidyl-arginine hydroxylation
Q5A_RS09990	COG0745	RESPONSE REGULATOR receiver
Q5A_RS10025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Q5A_RS10030	COG2915	High frequency lysogenization protein hflD homolog
Q5A_RS10035	COG0482	sulfurtransferase activity
Q5A_RS10045	COG1187	pseudouridine synthase activity
Q5A_RS10050	COG0538	isocitrate dehydrogenase activity
Q5A_RS10055	COG0582	viral genome integration into host DNA
Q5A_RS10130	COG2135	peptidase activity
Q5A_RS10140	COG3064	Membrane
Q5A_RS10150	COG0628	permease
Q5A_RS10155	COG0456	acetyltransferase
Q5A_RS10165	COG1609	Transcriptional regulator
Q5A_RS10175	COG0673	inositol 2-dehydrogenase activity
Q5A_RS10180	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS10215	COG3254	rhamnose metabolic process
Q5A_RS10250	COG1278	Cold shock
Q5A_RS10255	COG0589	response to stress
Q5A_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS10265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Q5A_RS10270	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS10275	COG1396	sequence-specific DNA binding
Q5A_RS10275	COG1917	Cupin 2, conserved barrel domain protein
Q5A_RS10280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Q5A_RS10285	COG0174	glutamine synthetase
Q5A_RS10290	COG0531	amino acid
Q5A_RS10330	COG1605	Chorismate mutase
Q5A_RS10345	COG1228	amidohydrolase
Q5A_RS10355	COG0402	S-adenosylhomocysteine deaminase activity
Q5A_RS10365	COG2358	TRAP transporter, solute receptor (TAXI family
Q5A_RS10370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Q5A_RS10375	COG1116	anion transmembrane transporter activity
Q5A_RS10380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Q5A_RS10390	COG0371	Dehydrogenase
Q5A_RS10405	COG2211	Major facilitator Superfamily
Q5A_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS10420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Q5A_RS10430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Q5A_RS10445	COG0477	Major facilitator Superfamily
Q5A_RS10465	COG0402	S-adenosylhomocysteine deaminase activity
Q5A_RS10470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Q5A_RS10475	COG3493	citrate carrier protein
Q5A_RS10530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Q5A_RS10530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Q5A_RS10535	COG3008	intermembrane lipid transfer
Q5A_RS10540	COG2995	paraquat-inducible protein a
Q5A_RS10545	COG1956	GAF domain-containing protein
Q5A_RS10550	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Q5A_RS10555	COG0793	Belongs to the peptidase S41A family
Q5A_RS10565	COG0501	Belongs to the peptidase M48B family
Q5A_RS10570	COG2814	Major facilitator Superfamily
Q5A_RS10580	COG1823	symporter activity
Q5A_RS10585	COG1988	membrane-bound metal-dependent
Q5A_RS10590	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS10600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Q5A_RS10615	COG3001	Fructosamine kinase
Q5A_RS10625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Q5A_RS10630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Q5A_RS10635	COG1121	(ABC) transporter
Q5A_RS10640	COG0803	Belongs to the bacterial solute-binding protein 9 family
Q5A_RS10670	COG0814	amino acid
Q5A_RS10690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Q5A_RS10700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Q5A_RS10705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Q5A_RS10710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Q5A_RS10720	COG0776	regulation of translation
Q5A_RS10730	COG4139	cobalamin transport
Q5A_RS10735	COG0386	Belongs to the glutathione peroxidase family
Q5A_RS10740	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Q5A_RS10745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Q5A_RS10750	COG1215	transferase activity, transferring glycosyl groups
Q5A_RS10755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Q5A_RS10755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Q5A_RS10760	COG0726	polysaccharide deacetylase
Q5A_RS10765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Q5A_RS10770	COG2076	Multidrug Resistance protein
Q5A_RS10775	COG2076	Multidrug Resistance protein
Q5A_RS10780	COG0791	NLP P60 protein
Q5A_RS10785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Q5A_RS10835	COG2963	transposase activity
Q5A_RS10840	COG2801	Transposase and inactivated derivatives
Q5A_RS10870	COG0095	Lipoate-protein ligase
Q5A_RS10890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Q5A_RS10895	COG4558	Periplasmic binding protein
Q5A_RS10900	COG3720	iron ion transport
Q5A_RS10915	COG0386	Belongs to the glutathione peroxidase family
Q5A_RS10920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Q5A_RS10925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Q5A_RS10930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Q5A_RS10930	COG0574	Belongs to the PEP-utilizing enzyme family
Q5A_RS10935	COG0628	permease
Q5A_RS10940	COG0277	FAD linked oxidase domain protein
Q5A_RS10940	COG0247	lactate metabolic process
Q5A_RS10945	COG2050	protein possibly involved in aromatic compounds catabolism
Q5A_RS10955	COG0316	Belongs to the HesB IscA family
Q5A_RS10960	COG0719	Fe-S assembly protein
Q5A_RS10965	COG0396	ATPase activity
Q5A_RS10970	COG0719	Fe-S assembly protein
Q5A_RS10975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Q5A_RS10980	COG2166	iron-sulfur cluster assembly
Q5A_RS10985	COG1388	LysM domain
Q5A_RS10985	COG1376	ErfK ybiS ycfS ynhG family protein
Q5A_RS10995	COG0469	pyruvate kinase activity
Q5A_RS11020	COG0534	Mate efflux family protein
Q5A_RS11025	COG0307	riboflavin synthase, alpha
Q5A_RS11040	COG2814	Major facilitator Superfamily
Q5A_RS11045	COG0583	DNA-binding transcription factor activity
Q5A_RS11050	COG1609	Transcriptional regulator
Q5A_RS11055	COG0791	NLP P60 protein
Q5A_RS11060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Q5A_RS11070	COG0346	lactoylglutathione lyase activity
Q5A_RS11075	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Q5A_RS11080	COG1902	pentaerythritol trinitrate reductase activity
Q5A_RS11085	COG1309	transcriptional regulator
Q5A_RS11090	COG2194	sulfuric ester hydrolase activity
Q5A_RS11100	COG0583	DNA-binding transcription factor activity
Q5A_RS11105	COG3313	Fe-S protein
Q5A_RS11110	COG4989	oxidoreductase activity
Q5A_RS11115	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Q5A_RS11125	COG1289	transmembrane transporter activity
Q5A_RS11130	COG1566	PFAM secretion protein HlyD family protein
Q5A_RS11135	COG1846	Transcriptional regulator
Q5A_RS11140	COG3133	Outer membrane lipoprotein
Q5A_RS11145	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Q5A_RS11150	COG3895	Periplasmic Protein
Q5A_RS11155	COG0259	pyridoxamine-phosphate oxidase activity
Q5A_RS11160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Q5A_RS11195	COG0625	glutathione transferase activity
Q5A_RS11210	COG1418	mRNA catabolic process
Q5A_RS11265	COG3135	benzoate transporter
Q5A_RS11270	COG1396	sequence-specific DNA binding
Q5A_RS11275	COG1505	serine-type exopeptidase activity
Q5A_RS11280	COG3104	oligopeptide transport
Q5A_RS11290	COG2211	Major facilitator Superfamily
Q5A_RS11295	COG3507	Belongs to the glycosyl hydrolase 43 family
Q5A_RS11300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Q5A_RS11310	COG4659	FMN binding
Q5A_RS11320	COG3708	Transcriptional regulator
Q5A_RS11320	COG2207	Transcriptional regulator
Q5A_RS11325	COG4656	Part of a membrane complex involved in electron transport
Q5A_RS11330	COG2878	Part of a membrane complex involved in electron transport
Q5A_RS11335	COG4657	Part of a membrane complex involved in electron transport
Q5A_RS11345	COG2160	L-arabinose isomerase activity
Q5A_RS11350	COG1069	ribulokinase activity
Q5A_RS11355	COG1879	ABC-type sugar transport system periplasmic component
Q5A_RS11360	COG1129	ABC transporter
Q5A_RS11365	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS11380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Q5A_RS11385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Q5A_RS11390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Q5A_RS11395	COG0673	inositol 2-dehydrogenase activity
Q5A_RS11400	COG0385	Bile acid
Q5A_RS11405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Q5A_RS11440	COG0205	6-phosphofructokinase activity
Q5A_RS11445	COG1349	DNA-binding transcription factor activity
Q5A_RS11450	COG0494	nUDIX hydrolase
Q5A_RS11460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Q5A_RS11465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS11465	COG1263	PTS System
Q5A_RS11470	COG1609	Transcriptional regulator
Q5A_RS11485	COG0583	DNA-binding transcription factor activity
Q5A_RS11495	COG0583	DNA-binding transcription factor activity
Q5A_RS11505	COG5339	Protein conserved in bacteria
Q5A_RS11520	COG0114	fumarate hydratase activity
Q5A_RS11525	COG2378	regulation of single-species biofilm formation
Q5A_RS11540	COG2814	Major facilitator Superfamily
Q5A_RS11545	COG0583	DNA-binding transcription factor activity
Q5A_RS11550	COG1940	carbohydrate kinase activity
Q5A_RS11555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Q5A_RS11565	COG0477	Major facilitator Superfamily
Q5A_RS11580	COG1742	UPF0060 membrane protein
Q5A_RS11585	COG4221	oxidoreductase activity
Q5A_RS11595	COG0667	Aldo Keto reductase
Q5A_RS11600	COG0477	Major facilitator Superfamily
Q5A_RS11605	COG3842	ATPase activity
Q5A_RS11610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Q5A_RS11625	COG2182	Extracellular solute-binding protein
Q5A_RS11630	COG1940	carbohydrate kinase activity
Q5A_RS11635	COG0402	S-adenosylhomocysteine deaminase activity
Q5A_RS11645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Q5A_RS11665	COG2188	Transcriptional regulator
Q5A_RS11670	COG0366	Alpha amylase catalytic
Q5A_RS11675	COG0339	signal peptide processing
Q5A_RS11680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Q5A_RS11685	COG2271	Major facilitator Superfamily
Q5A_RS11690	COG1335	isochorismatase
Q5A_RS11695	COG3473	Maleate cis-trans isomerase
Q5A_RS11700	COG0596	Alpha beta hydrolase
Q5A_RS11705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Q5A_RS11710	COG2309	aminopeptidase activity
Q5A_RS11715	COG1846	Transcriptional regulator
Q5A_RS11720	COG2080	2 iron, 2 sulfur cluster binding
Q5A_RS11725	COG2010	Cytochrome c
Q5A_RS11725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Q5A_RS11745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Q5A_RS11775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS11775	COG1263	PTS System
Q5A_RS11775	COG2190	(PTS) system
Q5A_RS11780	COG2723	6-phospho-beta-galactosidase activity
Q5A_RS11785	COG3711	transcriptional antiterminator
Q5A_RS11810	COG0019	diaminopimelate decarboxylase activity
Q5A_RS11815	COG2431	L-lysine efflux transmembrane transporter activity
Q5A_RS11820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Q5A_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS11895	COG2814	Major facilitator Superfamily
Q5A_RS11900	COG1215	transferase activity, transferring glycosyl groups
Q5A_RS11930	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Q5A_RS11935	COG0747	negative chemotaxis
Q5A_RS11940	COG0601	transmembrane transport
Q5A_RS11945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Q5A_RS11950	COG0444	Belongs to the ABC transporter superfamily
Q5A_RS11955	COG4608	Belongs to the ABC transporter superfamily
Q5A_RS11970	COG0583	DNA-binding transcription factor activity
Q5A_RS11985	COG0768	penicillin binding
Q5A_RS12015	COG1126	abc transporter atp-binding protein
Q5A_RS12020	COG0765	amino acid transport
Q5A_RS12030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Q5A_RS12035	COG2079	MmgE PrpD family protein
Q5A_RS12040	COG0583	DNA-binding transcription factor activity
Q5A_RS12060	COG2814	Major facilitator Superfamily
Q5A_RS12065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Q5A_RS12085	COG0371	Dehydrogenase
Q5A_RS12095	COG1309	transcriptional regulator
Q5A_RS12145	COG0583	DNA-binding transcription factor activity
Q5A_RS12175	COG2315	Protein conserved in bacteria
Q5A_RS12185	COG2182	Extracellular solute-binding protein
Q5A_RS12190	COG1175	transmembrane transport
Q5A_RS12195	COG3833	ABC-type maltose transport systems, permease component
Q5A_RS12205	COG1874	Beta-galactosidase
Q5A_RS12225	COG1309	transcriptional regulator
Q5A_RS12245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Q5A_RS12250	COG2862	Uncharacterized protein family, UPF0114
Q5A_RS12260	COG4558	Periplasmic binding protein
Q5A_RS12275	COG0673	inositol 2-dehydrogenase activity
Q5A_RS12295	COG0675	Transposase, IS605 OrfB family
Q5A_RS12300	COG2814	Major facilitator Superfamily
Q5A_RS12305	COG0583	DNA-binding transcription factor activity
Q5A_RS12330	COG1522	sequence-specific DNA binding
Q5A_RS12350	COG1902	pentaerythritol trinitrate reductase activity
Q5A_RS12380	COG3284	Transcriptional regulator
Q5A_RS12395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS12405	COG3300	MHYT domain
Q5A_RS12405	COG5001	Diguanylate cyclase
Q5A_RS12410	COG4993	Dehydrogenase
Q5A_RS12460	COG3328	transposase activity
Q5A_RS12480	COG0076	glutamate decarboxylase activity
Q5A_RS12485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Q5A_RS12530	COG1609	Transcriptional regulator
Q5A_RS12540	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Q5A_RS12540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Q5A_RS12545	COG2723	6-phospho-beta-galactosidase activity
Q5A_RS12550	COG1447	Phosphotransferase system cellobiose-specific component IIA
Q5A_RS12560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Q5A_RS12580	COG2249	NAD(P)H dehydrogenase (quinone) activity
Q5A_RS12585	COG2249	NAD(P)H dehydrogenase (quinone) activity
Q5A_RS12590	COG1733	regulation of RNA biosynthetic process
Q5A_RS12625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Q5A_RS12630	COG0604	alcohol dehydrogenase
Q5A_RS12630	COG3321	synthase
Q5A_RS12640	COG1902	pentaerythritol trinitrate reductase activity
Q5A_RS12645	COG0693	protein deglycase activity
Q5A_RS12660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Q5A_RS12695	COG3135	benzoate transporter
Q5A_RS12700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Q5A_RS12705	COG1396	sequence-specific DNA binding
Q5A_RS12715	COG0583	DNA-binding transcription factor activity
Q5A_RS12740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Q5A_RS12745	COG2011	ABC-type metal ion transport system permease component
Q5A_RS12750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Q5A_RS12760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Q5A_RS12765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Q5A_RS12770	COG1045	serine acetyltransferase
Q5A_RS12780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Q5A_RS12785	COG2271	Major facilitator Superfamily
Q5A_RS12790	COG1737	Transcriptional regulator
Q5A_RS12795	COG2723	6-phospho-beta-galactosidase activity
Q5A_RS12805	COG3485	protocatechuate 3,4-dioxygenase
Q5A_RS12810	COG3485	protocatechuate 3,4-dioxygenase
Q5A_RS12815	COG0583	DNA-binding transcription factor activity
Q5A_RS12820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Q5A_RS12835	COG2814	Major facilitator Superfamily
Q5A_RS12845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Q5A_RS12850	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Q5A_RS12850	COG1082	Xylose isomerase domain protein TIM barrel
Q5A_RS12870	COG1414	Transcriptional regulator
Q5A_RS12890	COG3048	D-serine ammonia-lyase activity
Q5A_RS12905	COG5507	3-demethylubiquinone-9 3-methyltransferase
Q5A_RS12910	COG2199	diguanylate cyclase activity
Q5A_RS12920	COG2011	ABC-type metal ion transport system permease component
Q5A_RS12940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Q5A_RS12955	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS12960	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS12965	COG1129	ABC transporter
Q5A_RS12975	COG0366	Alpha amylase catalytic
Q5A_RS12980	COG3842	ATPase activity
Q5A_RS13000	COG1653	transport
Q5A_RS13005	COG0583	DNA-binding transcription factor activity
Q5A_RS13010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS13010	COG1263	PTS System
Q5A_RS13010	COG2190	(PTS) system
Q5A_RS13020	COG3264	Mechanosensitive ion channel
Q5A_RS13020	COG1196	nuclear chromosome segregation
Q5A_RS13065	COG1917	Cupin 2, conserved barrel domain protein
Q5A_RS13065	COG2207	Transcriptional regulator
Q5A_RS13100	COG2239	Acts as a magnesium transporter
Q5A_RS13110	COG0657	acetylesterase activity
Q5A_RS13120	COG1902	pentaerythritol trinitrate reductase activity
Q5A_RS13125	COG0583	DNA-binding transcription factor activity
Q5A_RS13135	COG0583	DNA-binding transcription factor activity
Q5A_RS13155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Q5A_RS13160	COG0697	spore germination
Q5A_RS13210	COG3158	transport of potassium into the cell
Q5A_RS13215	COG0583	DNA-binding transcription factor activity
Q5A_RS13270	COG0306	phosphate transporter
Q5A_RS13280	COG1686	Belongs to the peptidase S11 family
Q5A_RS13285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Q5A_RS13310	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Q5A_RS13325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Q5A_RS13335	COG0589	response to stress
Q5A_RS13340	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Q5A_RS13345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Q5A_RS13355	COG0531	amino acid
Q5A_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS13370	COG0745	RESPONSE REGULATOR receiver
Q5A_RS13375	COG2205	protein histidine kinase activity
Q5A_RS13380	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Q5A_RS13395	COG3591	Belongs to the peptidase S1B family
Q5A_RS13400	COG1643	Atp-dependent helicase
Q5A_RS13405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Q5A_RS13410	COG3784	Protein of unknown function (DUF1318)
Q5A_RS13420	COG2911	Protein conserved in bacteria
Q5A_RS13425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Q5A_RS13430	COG3187	Heat shock protein
Q5A_RS13435	COG3042	response to heat
Q5A_RS13445	COG0674	pyruvate-flavodoxin oxidoreductase activity
Q5A_RS13445	COG1013	pyruvate-flavodoxin oxidoreductase activity
Q5A_RS13445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Q5A_RS13445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Q5A_RS13460	COG0037	tRNA processing
Q5A_RS13480	COG4166	transmembrane transport
Q5A_RS13490	COG2866	Carboxypeptidase
Q5A_RS13495	COG4948	Mandelate Racemase Muconate Lactonizing
Q5A_RS13500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Q5A_RS13510	COG3768	UPF0283 membrane protein
Q5A_RS13515	COG3106	COG3106 Predicted ATPase
Q5A_RS13525	COG1983	PspC domain protein
Q5A_RS13535	COG1842	Phage shock protein A
Q5A_RS13540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Q5A_RS13555	COG1469	GTP cyclohydrolase I activity
Q5A_RS13565	COG4168	peptide transport system, permease
Q5A_RS13570	COG4171	peptide transport system, permease
Q5A_RS13575	COG4172	Belongs to the ABC transporter superfamily
Q5A_RS13585	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Q5A_RS13585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Q5A_RS13600	COG0243	molybdopterin cofactor binding
Q5A_RS13605	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
Q5A_RS13610	COG1966	Carbon starvation protein
Q5A_RS13620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Q5A_RS13625	COG1349	DNA-binding transcription factor activity
Q5A_RS13630	COG0235	Class ii aldolase
Q5A_RS13640	COG0023	Translation Initiation Factor
Q5A_RS13660	COG3385	transposase activity
Q5A_RS13665	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Q5A_RS13670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Q5A_RS13675	COG0671	phosphoesterase, PA-phosphatase related
Q5A_RS13685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Q5A_RS13695	COG0583	DNA-binding transcription factor activity
Q5A_RS13710	COG0616	signal peptide processing
Q5A_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS13720	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Q5A_RS13725	COG1187	pseudouridine synthase activity
Q5A_RS13740	COG0009	L-threonylcarbamoyladenylate synthase
Q5A_RS13745	COG0613	PHP domain protein
Q5A_RS13760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Q5A_RS13770	COG0133	tryptophan synthase activity
Q5A_RS13775	COG0159	tryptophan synthase activity
Q5A_RS13785	COG3047	cAMP biosynthetic process
Q5A_RS13790	COG0727	PFAM Uncharacterised protein family (UPF0153)
Q5A_RS13805	COG2917	probably involved in intracellular septation
Q5A_RS13810	COG1607	acyl-coa hydrolase
Q5A_RS13820	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Q5A_RS13825	COG2350	Protein conserved in bacteria
Q5A_RS13855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Q5A_RS13860	COG3099	Belongs to the UPF0263 family
Q5A_RS13870	COG0444	Belongs to the ABC transporter superfamily
Q5A_RS13875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Q5A_RS13890	COG4166	transmembrane transport
Q5A_RS13895	COG2095	MarC family integral membrane protein
Q5A_RS13900	COG1454	alcohol dehydrogenase
Q5A_RS13900	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS13925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Q5A_RS13930	COG0745	RESPONSE REGULATOR receiver
Q5A_RS13935	COG1752	Esterase of the alpha-beta hydrolase superfamily
Q5A_RS13940	COG3012	SEC-C Motif Domain Protein
Q5A_RS13945	COG0788	formyltetrahydrofolate deformylase activity
Q5A_RS13970	COG0708	Exodeoxyribonuclease III
Q5A_RS13975	COG0494	nUDIX hydrolase
Q5A_RS13985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Q5A_RS13990	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Q5A_RS14000	COG0778	Nitroreductase
Q5A_RS14005	COG0616	signal peptide processing
Q5A_RS14010	COG0252	asparaginase activity
Q5A_RS14015	COG1335	isochorismatase
Q5A_RS14025	COG3139	Protein of unknown function (DUF1315)
Q5A_RS14030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Q5A_RS14035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q5A_RS14045	COG3713	MltA-interacting MipA family protein
Q5A_RS14050	COG2766	serine protein kinase
Q5A_RS14055	COG2718	Belongs to the UPF0229 family
Q5A_RS14075	COG0401	homolog of Blt101
Q5A_RS14080	COG4774	siderophore transport
Q5A_RS14105	COG4171	peptide transport system, permease
Q5A_RS14120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Q5A_RS14125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Q5A_RS14130	COG2719	SpoVR family
Q5A_RS14135	COG2186	Transcriptional regulator
Q5A_RS14140	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Q5A_RS14145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Q5A_RS14150	COG2983	Belongs to the UPF0260 family
Q5A_RS14160	COG0179	Fumarylacetoacetate (FAA) hydrolase
Q5A_RS14165	COG2951	lytic endotransglycosylase activity
Q5A_RS14170	COG3100	YcgL domain-containing protein
Q5A_RS14175	COG0850	regulation of cytokinetic process
Q5A_RS14180	COG2894	cell division
Q5A_RS14185	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Q5A_RS14190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Q5A_RS14195	COG0318	PFAM AMP-dependent synthetase and ligase
Q5A_RS14200	COG3065	identical protein binding
Q5A_RS14210	COG1199	ATP-dependent helicase activity
Q5A_RS14215	COG0251	oxidation-reduction process
Q5A_RS14220	COG2076	Multidrug Resistance protein
Q5A_RS14225	COG2076	Multidrug Resistance protein
Q5A_RS14230	COG0800	Aldolase
Q5A_RS14235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Q5A_RS14240	COG1737	Transcriptional regulator
Q5A_RS14245	COG0469	pyruvate kinase activity
Q5A_RS14255	COG1560	Kdo2-lipid A biosynthetic process
Q5A_RS14260	COG0739	heme binding
Q5A_RS14265	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Q5A_RS14270	COG1121	(ABC) transporter
Q5A_RS14275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Q5A_RS14285	COG2255	four-way junction helicase activity
Q5A_RS14290	COG0632	four-way junction helicase activity
Q5A_RS14295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Q5A_RS14300	COG0217	transcriptional regulatory protein
Q5A_RS14305	COG0494	nUDIX hydrolase
Q5A_RS14310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Q5A_RS14315	COG1335	isochorismatase
Q5A_RS14320	COG1801	Protein of unknown function DUF72
Q5A_RS14325	COG3788	relative of glutathione S-transferase, MAPEG superfamily
Q5A_RS14330	COG2226	methyltransferase
Q5A_RS14335	COG0500	methyltransferase
Q5A_RS14345	COG3142	Participates in the control of copper homeostasis
Q5A_RS14365	COG3142	Participates in the control of copper homeostasis
Q5A_RS14370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Q5A_RS14375	COG3102	Protein conserved in bacteria
Q5A_RS14380	COG0018	arginyl-trna synthetase
Q5A_RS14395	COG3132	Protein of unknown function, DUF480
Q5A_RS14400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Q5A_RS14405	COG0477	Major facilitator Superfamily
Q5A_RS14415	COG2999	glutathione oxidoreductase activity
Q5A_RS14435	COG3097	Belongs to the UPF0267 family
Q5A_RS14440	COG3141	response to X-ray
Q5A_RS14445	COG0513	Belongs to the DEAD box helicase family
Q5A_RS14450	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Q5A_RS14455	COG3140	Belongs to the UPF0181 family
Q5A_RS14460	COG1216	Glycosyl transferase, family 2
Q5A_RS14470	COG0494	nUDIX hydrolase
Q5A_RS14475	COG1760	l-serine dehydratase
Q5A_RS14480	COG2200	EAL domain
Q5A_RS14485	COG1253	flavin adenine dinucleotide binding
Q5A_RS14490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS14490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Q5A_RS14495	COG3715	PTS system
Q5A_RS14500	COG3716	PTS system mannose fructose sorbose family IID component
Q5A_RS14505	COG4811	Protein of unknown function (DUF986)
Q5A_RS14510	COG1971	Probably functions as a manganese efflux pump
Q5A_RS14520	COG0640	Transcriptional regulator
Q5A_RS14525	COG2226	methyltransferase
Q5A_RS14550	COG1113	amino acid transport
Q5A_RS14590	COG2207	Transcriptional regulator
Q5A_RS14605	COG1652	LysM domain
Q5A_RS14625	COG2988	succinylglutamate desuccinylase activity
Q5A_RS14630	COG3724	N-succinylarginine dihydrolase activity
Q5A_RS14635	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS14640	COG3138	arginine N-succinyltransferase
Q5A_RS14645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Q5A_RS14655	COG4608	Belongs to the ABC transporter superfamily
Q5A_RS14660	COG0444	Belongs to the ABC transporter superfamily
Q5A_RS14670	COG0601	transmembrane transport
Q5A_RS14680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Q5A_RS14685	COG1271	oxidase subunit
Q5A_RS14690	COG1294	oxidase, subunit
Q5A_RS14700	COG2181	nitrate reductase activity
Q5A_RS14705	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Q5A_RS14710	COG1140	nitrate reductase beta subunit
Q5A_RS14715	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Q5A_RS14725	COG1216	Glycosyl transferase, family 2
Q5A_RS14725	COG0463	Glycosyl transferase, family 2
Q5A_RS14730	COG1216	Glycosyl transferase, family 2
Q5A_RS14740	COG1216	Glycosyl transferase, family 2
Q5A_RS14750	COG0463	Glycosyl transferase, family 2
Q5A_RS14775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Q5A_RS14780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Q5A_RS14785	COG3710	Transcriptional regulator
Q5A_RS14790	COG2223	nitrite transmembrane transporter activity
Q5A_RS14795	COG3850	Histidine kinase
Q5A_RS14800	COG2197	response regulator
Q5A_RS14805	COG4932	domain protein
Q5A_RS14825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Q5A_RS14825	COG1648	precorrin-2 dehydrogenase activity
Q5A_RS14830	COG0243	molybdopterin cofactor binding
Q5A_RS14835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Q5A_RS14835	COG2146	nitrite reductase [NAD(P)H] activity
Q5A_RS14840	COG1116	anion transmembrane transporter activity
Q5A_RS14850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Q5A_RS14855	COG3707	response regulator
Q5A_RS14865	COG4608	Belongs to the ABC transporter superfamily
Q5A_RS14870	COG0444	Belongs to the ABC transporter superfamily
Q5A_RS14875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Q5A_RS14880	COG0601	transmembrane transport
Q5A_RS14885	COG4166	transmembrane transport
Q5A_RS14900	COG0583	DNA-binding transcription factor activity
Q5A_RS14905	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Q5A_RS14910	COG4572	Cation transport regulator
Q5A_RS14915	COG2375	cellular response to nickel ion
Q5A_RS14920	COG0387	Pfam Sodium calcium exchanger
Q5A_RS14930	COG1702	phosphate starvation-inducible protein PhoH
Q5A_RS14935	COG4772	TonB-dependent receptor
Q5A_RS14950	COG0672	)-iron permease
Q5A_RS14960	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Q5A_RS14960	COG0506	proline dehydrogenase activity
Q5A_RS14960	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Q5A_RS14970	COG1126	abc transporter atp-binding protein
Q5A_RS14975	COG0765	amino acid transport
Q5A_RS14980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS14985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Q5A_RS14995	COG1191	sigma factor activity
Q5A_RS15045	COG1677	Flagellar hook-basal body complex protein FliE
Q5A_RS15055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Q5A_RS15065	COG1157	protein secretion by the type III secretion system
Q5A_RS15080	COG1580	Controls the rotational direction of flagella during chemotaxis
Q5A_RS15120	COG1256	bacterial-type flagellum assembly
Q5A_RS15140	COG4786	Flagellar basal body rod
Q5A_RS15150	COG1749	Flagellar hook protein flgE
Q5A_RS15155	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Q5A_RS15160	COG1558	bacterial-type flagellum-dependent cell motility
Q5A_RS15165	COG1815	bacterial-type flagellum-dependent cell motility
Q5A_RS15175	COG2747	anti-sigma28 factor FlgM
Q5A_RS15180	COG3418	PFAM FlgN family protein
Q5A_RS15200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Q5A_RS15205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Q5A_RS15210	COG1487	ribonuclease activity
Q5A_RS15220	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Q5A_RS15225	COG0745	RESPONSE REGULATOR receiver
Q5A_RS15235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Q5A_RS15240	COG0840	transmembrane signaling receptor activity
Q5A_RS15245	COG0840	transmembrane signaling receptor activity
Q5A_RS15255	COG0835	chemotaxis
Q5A_RS15260	COG0643	Histidine kinase
Q5A_RS15260	COG2198	Histidine kinase
Q5A_RS15265	COG1360	Flagellar Motor Protein
Q5A_RS15295	COG2130	NADP-dependent
Q5A_RS15300	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Q5A_RS15305	COG3483	tryptophan 2,3-dioxygenase activity
Q5A_RS15340	COG0545	Peptidyl-prolyl cis-trans isomerase
Q5A_RS15365	COG3539	Fimbrial protein
Q5A_RS15385	COG3121	Chaperone
Q5A_RS15390	COG3188	usher protein
Q5A_RS15425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Q5A_RS15440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Q5A_RS15465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Q5A_RS15515	COG4191	Histidine kinase
Q5A_RS15520	COG1414	Transcriptional regulator
Q5A_RS15530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Q5A_RS15535	COG0183	Belongs to the thiolase family
Q5A_RS15540	COG0596	Alpha beta hydrolase
Q5A_RS15550	COG0431	NADPH-dependent FMN reductase
Q5A_RS15555	COG1393	Belongs to the ArsC family
Q5A_RS15560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Q5A_RS15570	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Q5A_RS15610	COG1285	pathogenesis
Q5A_RS15615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Q5A_RS15655	COG0604	alcohol dehydrogenase
Q5A_RS15655	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS15655	COG3321	synthase
Q5A_RS15670	COG3753	Protein conserved in bacteria
Q5A_RS15675	COG2261	transglycosylase associated protein
Q5A_RS15685	COG2764	glyoxalase bleomycin resistance protein dioxygenase
Q5A_RS15695	COG5001	Diguanylate cyclase
Q5A_RS15695	COG2203	Gaf domain
Q5A_RS15695	COG3706	GGDEF domain
Q5A_RS15695	COG4251	negative regulation of phosphorylation
Q5A_RS15700	COG2030	dehydratase
Q5A_RS15700	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS15705	COG3396	Phenylacetate-CoA oxygenase
Q5A_RS15710	COG3460	Phenylacetate-CoA oxygenase
Q5A_RS15715	COG3396	Phenylacetate-CoA oxygenase
Q5A_RS15720	COG2151	metal-sulfur cluster biosynthetic enzyme
Q5A_RS15725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Q5A_RS15730	COG1024	Enoyl-CoA hydratase
Q5A_RS15735	COG1024	Enoyl-CoA hydratase
Q5A_RS15740	COG1250	3-hydroxyacyl-CoA dehydrogenase
Q5A_RS15750	COG0183	Belongs to the thiolase family
Q5A_RS15755	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Q5A_RS15760	COG3327	negative regulation of DNA-templated transcription, initiation
Q5A_RS15765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Q5A_RS15770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Q5A_RS15780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Q5A_RS15785	COG0697	spore germination
Q5A_RS15790	COG1113	amino acid transport
Q5A_RS15805	COG0583	DNA-binding transcription factor activity
Q5A_RS15810	COG0625	glutathione transferase activity
Q5A_RS15850	COG4993	Dehydrogenase
Q5A_RS15860	COG2223	nitrite transmembrane transporter activity
Q5A_RS15865	COG1486	melibiose metabolic process
Q5A_RS15875	COG0534	Mate efflux family protein
Q5A_RS15895	COG0673	inositol 2-dehydrogenase activity
Q5A_RS15915	COG3228	Belongs to the MtfA family
Q5A_RS15945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Q5A_RS15945	COG0475	glutathione-regulated potassium exporter activity
Q5A_RS15955	COG0583	DNA-binding transcription factor activity
Q5A_RS15960	COG4122	O-methyltransferase activity
Q5A_RS15975	COG3122	Protein conserved in bacteria
Q5A_RS15990	COG1609	Transcriptional regulator
Q5A_RS15995	COG1840	ABC-type Fe3 transport system, periplasmic component
Q5A_RS16005	COG3842	ATPase activity
Q5A_RS16015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q5A_RS16030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Q5A_RS16035	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Q5A_RS16040	COG1116	anion transmembrane transporter activity
Q5A_RS16045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Q5A_RS16050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Q5A_RS16065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Q5A_RS16080	COG0583	DNA-binding transcription factor activity
Q5A_RS16085	COG2814	Major facilitator Superfamily
Q5A_RS16090	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Q5A_RS16100	COG1846	Transcriptional regulator
Q5A_RS16105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Q5A_RS16110	COG0778	Nitroreductase
Q5A_RS16140	COG1881	PFAM PEBP family protein
Q5A_RS16145	COG2207	Transcriptional regulator
Q5A_RS16160	COG0583	DNA-binding transcription factor activity
Q5A_RS16175	COG0583	DNA-binding transcription factor activity
Q5A_RS16180	COG3177	Filamentation induced by cAMP protein fic
Q5A_RS16205	COG2856	Zn peptidase
Q5A_RS16220	COG4774	siderophore transport
Q5A_RS16225	COG2801	Transposase and inactivated derivatives
Q5A_RS16235	COG2223	nitrite transmembrane transporter activity
Q5A_RS16250	COG3238	Protein conserved in bacteria
Q5A_RS16270	COG0583	DNA-binding transcription factor activity
Q5A_RS16285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Q5A_RS16290	COG4172	Belongs to the ABC transporter superfamily
Q5A_RS16295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Q5A_RS16300	COG0601	transmembrane transport
Q5A_RS16350	COG0477	Major facilitator Superfamily
Q5A_RS16365	COG2079	MmgE PrpD family protein
Q5A_RS16370	COG0583	DNA-binding transcription factor activity
Q5A_RS16380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Q5A_RS16390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Q5A_RS16395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Q5A_RS16400	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS16405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Q5A_RS16410	COG0508	dehydrogenase complex catalyzes the overall conversion of
Q5A_RS16415	COG0022	dehydrogenase e1 component
Q5A_RS16420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Q5A_RS16430	COG3477	response to acidic pH
Q5A_RS16435	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Q5A_RS16440	COG2207	Transcriptional regulator
Q5A_RS16445	COG2249	NAD(P)H dehydrogenase (quinone) activity
Q5A_RS16450	COG0583	DNA-binding transcription factor activity
Q5A_RS16515	COG2814	Major facilitator Superfamily
Q5A_RS16520	COG0583	DNA-binding transcription factor activity
Q5A_RS16530	COG1250	3-hydroxyacyl-CoA dehydrogenase
Q5A_RS16540	COG2986	histidine ammonia-lyase
Q5A_RS16555	COG1174	glycine betaine transport
Q5A_RS16565	COG2814	Major facilitator Superfamily
Q5A_RS16600	COG0367	asparagine synthase
Q5A_RS16615	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
Q5A_RS16645	COG1473	amidohydrolase
Q5A_RS16650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS16655	COG2926	Belongs to the UPF0265 family
Q5A_RS16660	COG1289	transmembrane transporter activity
Q5A_RS16665	COG3023	N-Acetylmuramoyl-L-alanine amidase
Q5A_RS16690	COG2925	Exonuclease
Q5A_RS16695	COG0531	amino acid
Q5A_RS16700	COG0174	glutamine synthetase
Q5A_RS16705	COG1396	sequence-specific DNA binding
Q5A_RS16705	COG1917	Cupin 2, conserved barrel domain protein
Q5A_RS16710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Q5A_RS16715	COG1129	ABC transporter
Q5A_RS16720	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS16725	COG4771	TonB-dependent receptor
Q5A_RS16730	COG1120	ATPase activity
Q5A_RS16735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Q5A_RS16745	COG0833	amino acid
Q5A_RS16750	COG0583	DNA-binding transcription factor activity
Q5A_RS16755	COG2855	membrane
Q5A_RS16760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Q5A_RS16765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Q5A_RS16765	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Q5A_RS16765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Q5A_RS16770	COG1105	Belongs to the carbohydrate kinase PfkB family
Q5A_RS16785	COG3005	denitrification pathway
Q5A_RS16790	COG0243	molybdopterin cofactor binding
Q5A_RS16810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Q5A_RS16815	COG1312	Catalyzes the dehydration of D-mannonate
Q5A_RS16820	COG0246	Mannitol dehydrogenase
Q5A_RS16830	COG0523	cobalamin synthesis protein
Q5A_RS16835	COG0671	phosphoesterase, PA-phosphatase related
Q5A_RS16840	COG0791	NLP P60 protein
Q5A_RS16845	COG2200	EAL domain
Q5A_RS16850	COG4166	transmembrane transport
Q5A_RS16855	COG4174	ABC transporter (Permease)
Q5A_RS16860	COG4239	(ABC) transporter, permease
Q5A_RS16865	COG4172	Belongs to the ABC transporter superfamily
Q5A_RS16875	COG2814	Major facilitator Superfamily
Q5A_RS16880	COG1187	pseudouridine synthase activity
Q5A_RS16885	COG1061	Type III restriction enzyme res subunit
Q5A_RS16890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Q5A_RS16895	COG3081	Nucleoid-associated protein
Q5A_RS16900	COG3082	Protein of unknown function (DUF1414)
Q5A_RS16930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Q5A_RS16955	COG0346	lactoylglutathione lyase activity
Q5A_RS16965	COG2223	nitrite transmembrane transporter activity
Q5A_RS16970	COG0642	Histidine kinase
Q5A_RS16970	COG2198	Histidine kinase
Q5A_RS16980	COG2205	protein histidine kinase activity
Q5A_RS16980	COG0784	Response regulator, receiver
Q5A_RS16990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Q5A_RS16995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Q5A_RS17005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Q5A_RS17020	COG0814	amino acid
Q5A_RS17055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Q5A_RS17060	COG0596	Alpha beta hydrolase
Q5A_RS17065	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Q5A_RS17070	COG1169	isochorismate synthase
Q5A_RS17075	COG3459	Glycosyltransferase 36 associated
Q5A_RS17080	COG4575	ribosome binding
Q5A_RS17085	COG1063	alcohol dehydrogenase
Q5A_RS17090	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS17095	COG1609	Transcriptional regulator
Q5A_RS17125	COG0028	Belongs to the TPP enzyme family
Q5A_RS17135	COG1007	ATP synthesis coupled electron transport
Q5A_RS17140	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Q5A_RS17145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Q5A_RS17150	COG0713	ATP synthesis coupled electron transport
Q5A_RS17155	COG0839	Belongs to the complex I subunit 6 family
Q5A_RS17165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Q5A_RS17170	COG1034	ATP synthesis coupled electron transport
Q5A_RS17185	COG0649	NAD binding
Q5A_RS17185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Q5A_RS17190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Q5A_RS17195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Q5A_RS17200	COG3385	transposase activity
Q5A_RS17205	COG0583	DNA-binding transcription factor activity
Q5A_RS17210	COG0436	Aminotransferase
Q5A_RS17215	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Q5A_RS17220	COG0471	metal ion transport
Q5A_RS17220	COG0490	domain, Protein
Q5A_RS17225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Q5A_RS17230	COG3013	Belongs to the UPF0304 family
Q5A_RS17235	COG3092	negative regulation of chromosome organization
Q5A_RS17240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Q5A_RS17245	COG0280	phosphate acetyltransferase
Q5A_RS17245	COG0857	belongs to the CobB CobQ family
Q5A_RS17250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Q5A_RS17255	COG0622	Phosphoesterase
Q5A_RS17260	COG0625	glutathione transferase activity
Q5A_RS17265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Q5A_RS17270	COG1090	epimerase
Q5A_RS17285	COG4215	(ABC) transporter
Q5A_RS17290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS17295	COG0163	prenyltransferase activity
Q5A_RS17300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Q5A_RS17305	COG1286	toxin biosynthetic process
Q5A_RS17310	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Q5A_RS17315	COG0285	dihydrofolate synthase activity
Q5A_RS17320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Q5A_RS17325	COG0586	Pfam SNARE associated Golgi protein
Q5A_RS17335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Q5A_RS17340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Q5A_RS17350	COG0697	spore germination
Q5A_RS17355	COG0642	Histidine kinase
Q5A_RS17390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Q5A_RS17395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Q5A_RS17440	COG2195	Cleaves the N-terminal amino acid of tripeptides
Q5A_RS17445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Q5A_RS17460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Q5A_RS17465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Q5A_RS17465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Q5A_RS17475	COG3101	peptidyl-lysine hydroxylation
Q5A_RS17480	COG0730	response to heat
Q5A_RS17485	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Q5A_RS17490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Q5A_RS17495	COG2890	protein-(glutamine-N5) methyltransferase activity
Q5A_RS17500	COG2840	Smr protein MutS2
Q5A_RS17505	COG2062	phosphohistidine phosphatase, SixA
Q5A_RS17510	COG1250	3-hydroxyacyl-CoA dehydrogenase
Q5A_RS17510	COG1024	Enoyl-CoA hydratase
Q5A_RS17515	COG0183	Belongs to the thiolase family
Q5A_RS17520	COG3691	Protein conserved in bacteria
Q5A_RS17530	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Q5A_RS17545	COG4235	cytochrome complex assembly
Q5A_RS17545	COG3088	subunit of a heme lyase
Q5A_RS17550	COG4235	cytochrome complex assembly
Q5A_RS17550	COG3088	subunit of a heme lyase
Q5A_RS17555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Q5A_RS17560	COG1138	Cytochrome C-type biogenesis protein
Q5A_RS17565	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Q5A_RS17570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Q5A_RS17575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Q5A_RS17580	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Q5A_RS17590	COG2116	formate transmembrane transporter activity
Q5A_RS17615	COG0583	DNA-binding transcription factor activity
Q5A_RS17625	COG0697	spore germination
Q5A_RS17640	COG2951	lytic endotransglycosylase activity
Q5A_RS17650	COG1598	PFAM Uncharacterised protein family UPF0150
Q5A_RS17660	COG3038	cytochrome b561
Q5A_RS17665	COG0436	Aminotransferase
Q5A_RS17680	COG3275	phosphorelay sensor kinase activity
Q5A_RS17685	COG3279	Response regulator of the LytR AlgR family
Q5A_RS17695	COG2223	nitrite transmembrane transporter activity
Q5A_RS17710	COG1794	racemase activity, acting on amino acids and derivatives
Q5A_RS17725	COG3961	Belongs to the TPP enzyme family
Q5A_RS17730	COG0667	Aldo Keto reductase
Q5A_RS17740	COG1914	H( )-stimulated, divalent metal cation uptake system
Q5A_RS17745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Q5A_RS17760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Q5A_RS17785	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS17790	COG1535	isochorismatase
Q5A_RS17790	COG3433	isochorismatase activity
Q5A_RS17795	COG1021	2,3-dihydroxybenzoate-AMP ligase
Q5A_RS17800	COG1169	isochorismate synthase
Q5A_RS17805	COG4592	Periplasmic binding protein
Q5A_RS17815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Q5A_RS17820	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Q5A_RS17825	COG1120	ATPase activity
Q5A_RS17830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Q5A_RS17830	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
Q5A_RS17835	COG3251	PFAM MbtH domain protein
Q5A_RS17840	COG2382	esterase
Q5A_RS17845	COG4771	TonB-dependent receptor
Q5A_RS17850	COG0747	negative chemotaxis
Q5A_RS17870	COG4302	ethanolamine ammonia-lyase activity
Q5A_RS17875	COG4303	Ethanolamine ammonia lyase large subunit
Q5A_RS17890	COG0583	DNA-binding transcription factor activity
Q5A_RS17895	COG0385	Bile acid
Q5A_RS17900	COG3530	Putative quorum-sensing-regulated virulence factor
Q5A_RS17905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Q5A_RS17910	COG3115	cell septum assembly
Q5A_RS17915	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Q5A_RS17925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Q5A_RS17930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Q5A_RS17940	COG2205	protein histidine kinase activity
Q5A_RS17945	COG0745	RESPONSE REGULATOR receiver
Q5A_RS17950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS17960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Q5A_RS17970	COG4208	sulfate ABC transporter
Q5A_RS17975	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Q5A_RS17980	COG4150	thiosulfate binding
Q5A_RS17985	COG2837	iron assimilation
Q5A_RS18000	COG3111	PFAM Bacterial OB fold (BOF) protein
Q5A_RS18005	COG0456	acetyltransferase
Q5A_RS18015	COG0408	coproporphyrinogen oxidase activity
Q5A_RS18020	COG1671	Belongs to the UPF0178 family
Q5A_RS18030	COG0833	amino acid
Q5A_RS18035	COG2040	homocysteine
Q5A_RS18040	COG2801	Transposase and inactivated derivatives
Q5A_RS18080	COG0583	DNA-binding transcription factor activity
Q5A_RS18085	COG3397	chitin binding
Q5A_RS18090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Q5A_RS18095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Q5A_RS18100	COG3385	transposase activity
Q5A_RS18115	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Q5A_RS18135	COG0494	nUDIX hydrolase
Q5A_RS18140	COG3005	denitrification pathway
Q5A_RS18145	COG3043	anaerobic respiration
Q5A_RS18150	COG0243	molybdopterin cofactor binding
Q5A_RS18155	COG3062	negative regulation of establishment of protein localization
Q5A_RS18160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Q5A_RS18160	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
Q5A_RS18165	COG3850	Histidine kinase
Q5A_RS18170	COG2197	response regulator
Q5A_RS18180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Q5A_RS18185	COG4771	TonB-dependent receptor
Q5A_RS18215	COG3210	domain, Protein
Q5A_RS18235	COG3210	domain, Protein
Q5A_RS18240	COG2831	hemolysin activation secretion protein
Q5A_RS18250	COG0456	acetyltransferase
Q5A_RS18270	COG1393	Belongs to the ArsC family
Q5A_RS18275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Q5A_RS18280	COG1876	peptidase activity
Q5A_RS18305	COG0400	carboxylic ester hydrolase activity
Q5A_RS18315	COG2321	neutral zinc metallopeptidase
Q5A_RS18320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Q5A_RS18325	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Q5A_RS18330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Q5A_RS18335	COG2716	regulation of RNA biosynthetic process
Q5A_RS18340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Q5A_RS18345	COG0628	permease
Q5A_RS18380	COG4783	chaperone-mediated protein folding
Q5A_RS18385	COG1393	Belongs to the ArsC family
Q5A_RS18395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Q5A_RS18410	COG2261	transglycosylase associated protein
Q5A_RS18415	COG2233	PERMEase
Q5A_RS18420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Q5A_RS18425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Q5A_RS18430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Q5A_RS18445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Q5A_RS18455	COG0573	inorganic phosphate transmembrane transporter activity
Q5A_RS18460	COG0573	inorganic phosphate transmembrane transporter activity
Q5A_RS18465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Q5A_RS18480	COG2239	Acts as a magnesium transporter
Q5A_RS18495	COG0443	Heat shock 70 kDa protein
Q5A_RS18505	COG0529	Catalyzes the synthesis of activated sulfate
Q5A_RS18505	COG2046	Belongs to the sulfate adenylyltransferase family
Q5A_RS18515	COG0667	Aldo Keto reductase
Q5A_RS18520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS18525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Q5A_RS18530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Q5A_RS18535	COG2814	Major facilitator Superfamily
Q5A_RS18540	COG2205	protein histidine kinase activity
Q5A_RS18545	COG0745	RESPONSE REGULATOR receiver
Q5A_RS18560	COG3422	double-strand break repair
Q5A_RS18565	COG0826	peptidase U32
Q5A_RS18570	COG1597	lipid kinase activity
Q5A_RS18575	COG4948	Mandelate Racemase Muconate Lactonizing
Q5A_RS18580	COG1063	alcohol dehydrogenase
Q5A_RS18585	COG2271	Major facilitator Superfamily
Q5A_RS18590	COG0246	Mannitol dehydrogenase
Q5A_RS18600	COG1802	Transcriptional regulator
Q5A_RS18605	COG1830	Aldolase
Q5A_RS18620	COG0351	phosphomethylpyrimidine kinase
Q5A_RS18625	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Q5A_RS18630	COG0456	acetyltransferase
Q5A_RS18635	COG2814	Major facilitator Superfamily
Q5A_RS18650	COG3550	peptidyl-serine autophosphorylation
Q5A_RS18655	COG3550	peptidyl-serine autophosphorylation
Q5A_RS18675	COG2197	response regulator
Q5A_RS18680	COG0784	Response regulator, receiver
Q5A_RS18680	COG2198	Histidine kinase
Q5A_RS18680	COG2205	protein histidine kinase activity
Q5A_RS18690	COG1733	regulation of RNA biosynthetic process
Q5A_RS18705	COG0210	DNA helicase
Q5A_RS18710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Q5A_RS18715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Q5A_RS18715	COG0519	Catalyzes the synthesis of GMP from XMP
Q5A_RS18720	COG0517	IMP dehydrogenase activity
Q5A_RS18720	COG0516	GMP reductase activity
Q5A_RS18725	COG1570	exodeoxyribonuclease VII activity
Q5A_RS18735	COG2271	Major facilitator Superfamily
Q5A_RS18740	COG1609	Transcriptional regulator
Q5A_RS18755	COG1645	bacterial-type flagellum-dependent swarming motility
Q5A_RS18765	COG1160	GTP binding
Q5A_RS18770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Q5A_RS18775	COG2976	Protein conserved in bacteria
Q5A_RS18780	COG0124	histidyl-tRNA synthetase
Q5A_RS18785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Q5A_RS18790	COG1426	Protein conserved in bacteria
Q5A_RS18800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Q5A_RS18805	COG0105	UTP biosynthetic process
Q5A_RS18810	COG4953	penicillin-binding protein 1C
Q5A_RS18815	COG2373	Large extracellular alpha-helical protein
Q5A_RS18820	COG1263	PTS System
Q5A_RS18820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS18825	COG1486	melibiose metabolic process
Q5A_RS18830	COG1737	Transcriptional regulator
Q5A_RS18840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Q5A_RS18845	COG2975	iron-sulfur cluster assembly
Q5A_RS18850	COG0633	Ferredoxin
Q5A_RS18855	COG0443	Heat shock 70 kDa protein
Q5A_RS18860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Q5A_RS18865	COG0316	Belongs to the HesB IscA family
Q5A_RS18870	COG0822	iron-sulfur transferase activity
Q5A_RS18875	COG1104	cysteine desulfurase activity
Q5A_RS18880	COG1959	2 iron, 2 sulfur cluster binding
Q5A_RS18895	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
Q5A_RS18900	COG3683	transport system, periplasmic component
Q5A_RS18905	COG3711	transcriptional antiterminator
Q5A_RS18910	COG2814	Major facilitator Superfamily
Q5A_RS18915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Q5A_RS18920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Q5A_RS18920	COG1017	nitric oxide dioxygenase activity
Q5A_RS18930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Q5A_RS18935	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS18940	COG2801	Transposase and inactivated derivatives
Q5A_RS18950	COG0347	Belongs to the P(II) protein family
Q5A_RS18955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Q5A_RS18955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Q5A_RS18960	COG2204	response regulator
Q5A_RS18965	COG3170	Tfp pilus assembly protein FimV
Q5A_RS18970	COG2205	protein histidine kinase activity
Q5A_RS18980	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Q5A_RS18995	COG0560	Phosphoserine phosphatase
Q5A_RS19000	COG1263	PTS System
Q5A_RS19000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Q5A_RS19005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Q5A_RS19010	COG1737	Transcriptional regulator
Q5A_RS19020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Q5A_RS19025	COG0736	holo-[acyl-carrier-protein] synthase activity
Q5A_RS19030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Q5A_RS19035	COG1381	Involved in DNA repair and RecF pathway recombination
Q5A_RS19040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Q5A_RS19045	COG0571	ribonuclease III activity
Q5A_RS19050	COG0681	Belongs to the peptidase S26 family
Q5A_RS19055	COG0481	GTPase activity
Q5A_RS19065	COG3086	response to oxidative stress
Q5A_RS19085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Q5A_RS19090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Q5A_RS19095	COG0513	Belongs to the DEAD box helicase family
Q5A_RS19110	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
Q5A_RS19115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Q5A_RS19120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Q5A_RS19125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Q5A_RS19130	COG0497	DNA recombination
Q5A_RS19135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Q5A_RS19140	COG2914	Belongs to the UPF0125 (RnfH) family
Q5A_RS19145	COG2867	negative regulation of translational initiation
Q5A_RS19150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Q5A_RS19175	COG0667	Aldo Keto reductase
Q5A_RS19225	COG0583	DNA-binding transcription factor activity
Q5A_RS19230	COG0667	Aldo Keto reductase
Q5A_RS19240	COG2226	methyltransferase
Q5A_RS19250	COG2388	GCN5-related N-acetyl-transferase
Q5A_RS19255	COG2259	Doxx family
Q5A_RS19260	COG2840	Smr protein MutS2
Q5A_RS19280	COG0477	Major facilitator Superfamily
Q5A_RS19295	COG0583	DNA-binding transcription factor activity
Q5A_RS19320	COG4575	ribosome binding
Q5A_RS19330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Q5A_RS19340	COG1780	Probably involved in ribonucleotide reductase function
Q5A_RS19370	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS19390	COG3493	citrate carrier protein
Q5A_RS19405	COG4175	Glycine betaine
Q5A_RS19410	COG4176	ABC-type proline glycine betaine transport system permease component
Q5A_RS19415	COG2113	Glycine betaine
Q5A_RS19420	COG2113	Glycine betaine
Q5A_RS19425	COG0583	DNA-binding transcription factor activity
Q5A_RS19430	COG2814	Major facilitator Superfamily
Q5A_RS19440	COG1846	Transcriptional regulator
Q5A_RS19445	COG1538	Outer membrane efflux protein
Q5A_RS19450	COG1566	PFAM secretion protein HlyD family protein
Q5A_RS19455	COG2814	Major facilitator Superfamily
Q5A_RS19460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Q5A_RS19465	COG3118	belongs to the thioredoxin family
Q5A_RS19470	COG3148	PFAM DTW domain containing protein
Q5A_RS19475	COG0045	succinate-CoA ligase (ADP-forming) activity
Q5A_RS19475	COG1042	CoA-binding domain protein
Q5A_RS19475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Q5A_RS19480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Q5A_RS19485	COG5544	Lipoprotein
Q5A_RS19490	COG0477	Major facilitator Superfamily
Q5A_RS19500	COG2801	Transposase and inactivated derivatives
Q5A_RS19530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Q5A_RS19540	COG2011	ABC-type metal ion transport system permease component
Q5A_RS19545	COG1464	Belongs to the NlpA lipoprotein family
Q5A_RS19555	COG1720	tRNA m6t6A37 methyltransferase activity
Q5A_RS19560	COG0442	prolyl-tRNA aminoacylation
Q5A_RS19565	COG3015	lipoprotein NlpE involved in copper resistance
Q5A_RS19570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Q5A_RS19585	COG4568	rho-dependent transcription termination
Q5A_RS19595	COG0037	tRNA processing
Q5A_RS19600	COG0346	lactoylglutathione lyase activity
Q5A_RS19605	COG1982	Orn Lys Arg decarboxylase major
Q5A_RS19610	COG0825	malonyl-CoA metabolic process
Q5A_RS19620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Q5A_RS19625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Q5A_RS19630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Q5A_RS19640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Q5A_RS19645	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Q5A_RS19650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Q5A_RS19655	COG0750	zinc metalloprotease
Q5A_RS19660	COG0575	Belongs to the CDS family
Q5A_RS19665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Q5A_RS19670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Q5A_RS19675	COG0233	cytoplasmic translational termination
Q5A_RS19680	COG0528	UMP kinase activity
Q5A_RS19685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Q5A_RS19690	COG0052	Belongs to the universal ribosomal protein uS2 family
Q5A_RS19700	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Q5A_RS19720	COG0564	pseudouridine synthase activity
Q5A_RS19725	COG3098	single-species biofilm formation
Q5A_RS19730	COG2814	Major facilitator Superfamily
Q5A_RS19745	COG1611	Belongs to the LOG family
Q5A_RS19750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Q5A_RS19755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Q5A_RS19760	COG2363	Small membrane protein
Q5A_RS19765	COG0583	DNA-binding transcription factor activity
Q5A_RS19775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Q5A_RS19780	COG2166	iron-sulfur cluster assembly
Q5A_RS19785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Q5A_RS19790	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Q5A_RS19810	COG0860	N-Acetylmuramoyl-L-alanine amidase
Q5A_RS19815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Q5A_RS19815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Q5A_RS19820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Q5A_RS19825	COG1074	ATP-dependent DNA helicase activity
Q5A_RS19830	COG1025	Belongs to the peptidase M16 family
Q5A_RS19835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Q5A_RS19840	COG4967	type IV pilus modification protein PilV
Q5A_RS19860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Q5A_RS19865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Q5A_RS19875	COG0494	nUDIX hydrolase
Q5A_RS19880	COG3066	DNA modification
Q5A_RS19885	COG0861	Integral membrane protein TerC family
Q5A_RS19895	COG0667	Aldo Keto reductase
Q5A_RS19900	COG0477	Major facilitator Superfamily
Q5A_RS19905	COG0204	Acyl-transferase
Q5A_RS19905	COG0318	PFAM AMP-dependent synthetase and ligase
Q5A_RS19915	COG1609	Transcriptional regulator
Q5A_RS19925	COG1609	Transcriptional regulator
Q5A_RS19945	COG0583	DNA-binding transcription factor activity
Q5A_RS19950	COG2814	Major facilitator Superfamily
Q5A_RS19955	COG0583	DNA-binding transcription factor activity
Q5A_RS19975	COG4178	(ABC) transporter
Q5A_RS19980	COG2807	transmembrane transport
Q5A_RS19985	COG4615	Cyclic peptide transporter
Q5A_RS19990	COG0582	viral genome integration into host DNA
Q5A_RS19995	COG2197	response regulator
Q5A_RS20000	COG2197	response regulator
Q5A_RS20005	COG3539	Fimbrial protein
Q5A_RS20020	COG3121	Chaperone
Q5A_RS20030	COG0582	viral genome integration into host DNA
Q5A_RS20040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Q5A_RS20045	COG1538	Outer membrane efflux protein
Q5A_RS20055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS20080	COG0583	DNA-binding transcription factor activity
Q5A_RS20085	COG1304	FMN binding
Q5A_RS20090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Q5A_RS20095	COG1309	transcriptional regulator
Q5A_RS20105	COG1942	4-Oxalocrotonate Tautomerase
Q5A_RS20110	COG5265	(ABC) transporter
Q5A_RS20130	COG4942	peptidase
Q5A_RS20135	COG3247	response to pH
Q5A_RS20140	COG0484	heat shock protein binding
Q5A_RS20150	COG1278	Cold shock
Q5A_RS20195	COG2885	chlorophyll binding
Q5A_RS20230	COG3188	usher protein
Q5A_RS20310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Q5A_RS20315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Q5A_RS20320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Q5A_RS20325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Q5A_RS20330	COG4974	Belongs to the 'phage' integrase family
Q5A_RS20335	COG0716	FMN binding
Q5A_RS20340	COG4452	Inner membrane protein CreD
Q5A_RS20345	COG2205	protein histidine kinase activity
Q5A_RS20350	COG0745	RESPONSE REGULATOR receiver
Q5A_RS20360	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Q5A_RS20365	COG0354	folic acid binding
Q5A_RS20370	COG1272	protein, Hemolysin III
Q5A_RS20415	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS20420	COG3713	MltA-interacting MipA family protein
Q5A_RS20445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Q5A_RS20445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Q5A_RS20450	COG0509	glycine decarboxylation via glycine cleavage system
Q5A_RS20455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Q5A_RS20460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Q5A_RS20465	COG1509	lysine 2,3-aminomutase activity
Q5A_RS20480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Q5A_RS20485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Q5A_RS20490	COG0006	proline dipeptidase activity
Q5A_RS20495	COG3079	Belongs to the UPF0149 family
Q5A_RS20500	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Q5A_RS20510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Q5A_RS20515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Q5A_RS20525	COG0583	DNA-binding transcription factor activity
Q5A_RS20535	COG1279	arginine transmembrane transporter activity
Q5A_RS20540	COG1414	Transcriptional regulator
Q5A_RS20545	COG1129	ABC transporter
Q5A_RS20550	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS20570	COG2731	YhcH YjgK YiaL family protein
Q5A_RS20580	COG1070	Carbohydrate kinase
Q5A_RS20585	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Q5A_RS20590	COG3623	hexulose-6-phosphate isomerase
Q5A_RS20595	COG0235	Class ii aldolase
Q5A_RS20610	COG0191	fructose-bisphosphate aldolase activity
Q5A_RS20615	COG0126	phosphoglycerate kinase activity
Q5A_RS20620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q5A_RS20625	COG3842	ATPase activity
Q5A_RS20630	COG1175	transmembrane transport
Q5A_RS20640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Q5A_RS20645	COG0501	Belongs to the peptidase M48B family
Q5A_RS20660	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Q5A_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS20680	COG2271	Major facilitator Superfamily
Q5A_RS20695	COG1414	Transcriptional regulator
Q5A_RS20715	COG2146	nitrite reductase [NAD(P)H] activity
Q5A_RS20720	COG1187	pseudouridine synthase activity
Q5A_RS20725	COG0010	Belongs to the arginase family
Q5A_RS20730	COG1166	arginine decarboxylase activity
Q5A_RS20735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Q5A_RS20745	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
Q5A_RS20750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Q5A_RS20755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Q5A_RS20760	COG1120	ATPase activity
Q5A_RS20765	COG4774	siderophore transport
Q5A_RS20770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Q5A_RS20775	COG1643	Atp-dependent helicase
Q5A_RS20780	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Q5A_RS20785	COG1489	DNA binding
Q5A_RS20795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Q5A_RS20805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Q5A_RS20810	COG0642	Histidine kinase
Q5A_RS20815	COG0745	RESPONSE REGULATOR receiver
Q5A_RS20820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Q5A_RS20825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Q5A_RS20830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Q5A_RS20835	COG0726	polysaccharide deacetylase
Q5A_RS20840	COG0842	Transport permease protein
Q5A_RS20845	COG1131	(ABC) transporter
Q5A_RS20850	COG0288	reversible hydration of carbon dioxide
Q5A_RS20860	COG2132	Multicopper oxidase
Q5A_RS20870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Q5A_RS20875	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Q5A_RS20880	COG3112	Uncharacterised protein family (UPF0231)
Q5A_RS20890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Q5A_RS20895	COG0508	dehydrogenase complex catalyzes the overall conversion of
Q5A_RS20900	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Q5A_RS20905	COG2186	Transcriptional regulator
Q5A_RS20910	COG1113	amino acid transport
Q5A_RS20915	COG2211	Major facilitator Superfamily
Q5A_RS20920	COG3940	Belongs to the glycosyl hydrolase 43 family
Q5A_RS20930	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Q5A_RS20935	COG3708	Transcriptional regulator
Q5A_RS20935	COG2207	Transcriptional regulator
Q5A_RS20940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Q5A_RS20940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Q5A_RS20945	COG3091	SprT-like family
Q5A_RS20950	COG2356	endonuclease I
Q5A_RS20955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Q5A_RS20960	COG0189	ligase activity
Q5A_RS20965	COG1678	Uncharacterized ACR, COG1678
Q5A_RS20970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Q5A_RS20975	COG2805	Type II/IV secretion system protein
Q5A_RS20980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Q5A_RS20985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Q5A_RS20990	COG0762	integral membrane protein
Q5A_RS20995	COG1872	DUF167
Q5A_RS21000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Q5A_RS21005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Q5A_RS21020	COG2066	Belongs to the glutaminase family
Q5A_RS21025	COG3171	Protein conserved in bacteria
Q5A_RS21030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Q5A_RS21035	COG1194	a g-specific adenine glycosylase
Q5A_RS21040	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Q5A_RS21045	COG0741	lytic transglycosylase activity
Q5A_RS21050	COG1982	Orn Lys Arg decarboxylase major
Q5A_RS21100	COG2801	Transposase and inactivated derivatives
Q5A_RS21165	COG3121	Chaperone
Q5A_RS21170	COG3188	usher protein
Q5A_RS21210	COG3121	Chaperone
Q5A_RS21240	COG3188	usher protein
Q5A_RS21245	COG3121	Chaperone
Q5A_RS21260	COG0475	glutathione-regulated potassium exporter activity
Q5A_RS21290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Q5A_RS21320	COG0697	spore germination
Q5A_RS21405	COG3188	usher protein
Q5A_RS21460	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS21465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Q5A_RS21485	COG0076	glutamate decarboxylase activity
Q5A_RS21505	COG0309	Hydrogenase expression formation protein (HypE)
Q5A_RS21510	COG0409	Hydrogenase expression formation protein
Q5A_RS21515	COG0298	carbon dioxide binding
Q5A_RS21520	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Q5A_RS21525	COG0375	protein maturation
Q5A_RS21535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Q5A_RS21540	COG0651	ATP synthesis coupled electron transport
Q5A_RS21545	COG0650	Formate hydrogenlyase subunit 4
Q5A_RS21550	COG3261	NADH dehydrogenase
Q5A_RS21550	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Q5A_RS21555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Q5A_RS21560	COG3260	NADH ubiquinone oxidoreductase 20
Q5A_RS21570	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Q5A_RS21575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Q5A_RS21580	COG3383	formate dehydrogenase (NAD+) activity
Q5A_RS21585	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Q5A_RS21590	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Q5A_RS21600	COG0454	-acetyltransferase
Q5A_RS21630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Q5A_RS21630	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Q5A_RS21650	COG0477	Major facilitator Superfamily
Q5A_RS21695	COG3210	domain, Protein
Q5A_RS21705	COG2831	hemolysin activation secretion protein
Q5A_RS21740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Q5A_RS21750	COG3609	addiction module antidote protein, CC2985 family
Q5A_RS21755	COG0848	biopolymer transport protein
Q5A_RS21770	COG0586	Pfam SNARE associated Golgi protein
Q5A_RS21775	COG0583	DNA-binding transcription factor activity
Q5A_RS21785	COG2207	Transcriptional regulator
Q5A_RS21790	COG1979	alcohol dehydrogenase
Q5A_RS21795	COG0656	L-ascorbic acid biosynthetic process
Q5A_RS21800	COG2723	6-phospho-beta-galactosidase activity
Q5A_RS21805	COG1447	Phosphotransferase system cellobiose-specific component IIA
Q5A_RS21810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Q5A_RS21820	COG0741	lytic transglycosylase activity
Q5A_RS21830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Q5A_RS21835	COG2211	Major facilitator Superfamily
Q5A_RS21840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Q5A_RS21845	COG0583	DNA-binding transcription factor activity
Q5A_RS21870	COG0583	DNA-binding transcription factor activity
Q5A_RS21875	COG3240	lipase activity
Q5A_RS21880	COG2132	Multicopper oxidase
Q5A_RS21885	COG0204	Acyl-transferase
Q5A_RS21890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Q5A_RS21895	COG2249	NAD(P)H dehydrogenase (quinone) activity
Q5A_RS21900	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Q5A_RS21905	COG0583	DNA-binding transcription factor activity
Q5A_RS21910	COG0187	DNA topoisomerase II activity
Q5A_RS21915	COG3150	esterase
Q5A_RS21930	COG0494	nUDIX hydrolase
Q5A_RS21940	COG1538	Outer membrane efflux protein
Q5A_RS21950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Q5A_RS21950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Q5A_RS21950	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Q5A_RS21955	COG1461	Dihydroxyacetone kinase
Q5A_RS21960	COG2376	Dihydroxyacetone kinase
Q5A_RS21970	COG5463	Belongs to the UPF0441 family
Q5A_RS21975	COG0754	glutathionylspermidine amidase activity
Q5A_RS21980	COG3384	dioxygenase
Q5A_RS21990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Q5A_RS21995	COG2960	long-chain fatty acid transporting porin activity
Q5A_RS22000	COG0531	amino acid
Q5A_RS22005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Q5A_RS22005	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Q5A_RS22010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Q5A_RS22015	COG3025	triphosphatase activity
Q5A_RS22020	COG4991	sh3 domain protein
Q5A_RS22025	COG0617	tRNA 3'-terminal CCA addition
Q5A_RS22030	COG1968	undecaprenyl-diphosphatase activity
Q5A_RS22035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Q5A_RS22040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Q5A_RS22055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Q5A_RS22060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Q5A_RS22065	COG0358	DNA primase activity
Q5A_RS22075	COG3663	DNA glycosylase
Q5A_RS22090	COG0625	glutathione transferase activity
Q5A_RS22100	COG1012	belongs to the aldehyde dehydrogenase family
Q5A_RS22105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Q5A_RS22120	COG0446	pyridine nucleotide-disulphide oxidoreductase
Q5A_RS22120	COG1902	pentaerythritol trinitrate reductase activity
Q5A_RS22125	COG2813	Specifically methylates the guanine in position
Q5A_RS22130	COG3549	Plasmid maintenance system killer
Q5A_RS22135	COG3093	addiction module antidote protein HigA
Q5A_RS22140	COG1451	nucleotide metabolic process
Q5A_RS22145	COG0673	inositol 2-dehydrogenase activity
Q5A_RS22155	COG0861	Integral membrane protein TerC family
Q5A_RS22160	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Q5A_RS22170	COG2721	sulfolactate sulfo-lyase activity
Q5A_RS22175	COG1904	glucuronate isomerase
Q5A_RS22180	COG2271	Major facilitator Superfamily
Q5A_RS22195	COG0586	Pfam SNARE associated Golgi protein
Q5A_RS22200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Q5A_RS22210	COG4575	ribosome binding
Q5A_RS22215	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
Q5A_RS22225	COG2259	Doxx family
Q5A_RS22230	COG0435	Glutathione S-transferase
Q5A_RS22235	COG0583	DNA-binding transcription factor activity
Q5A_RS22240	COG1741	Belongs to the pirin family
Q5A_RS22250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Q5A_RS22255	COG3107	peptidoglycan biosynthetic process
Q5A_RS22260	COG0792	nuclease activity
Q5A_RS22265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Q5A_RS22270	COG2823	Periplasmic or secreted lipoprotein
Q5A_RS22275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Q5A_RS22280	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Q5A_RS22285	COG0784	Response regulator, receiver
Q5A_RS22285	COG2198	Histidine kinase
Q5A_RS22285	COG5002	protein histidine kinase activity
Q5A_RS22295	COG0070	glutamate synthase
Q5A_RS22295	COG0069	glutamate synthase activity
Q5A_RS22295	COG0067	glutamate synthase
Q5A_RS22300	COG0493	'glutamate synthase
Q5A_RS22305	COG2969	positive regulation of protein catabolic process
Q5A_RS22310	COG0625	glutathione transferase activity
Q5A_RS22315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Q5A_RS22320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Q5A_RS22325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Q5A_RS22330	COG3105	Protein conserved in bacteria
Q5A_RS22335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Q5A_RS22340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Q5A_RS22345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Q5A_RS22350	COG5007	Belongs to the BolA IbaG family
Q5A_RS22355	COG3113	response to antibiotic
Q5A_RS22360	COG2854	intermembrane phospholipid transfer
Q5A_RS22365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Q5A_RS22370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Q5A_RS22375	COG1127	ABC transporter
Q5A_RS22380	COG0530	calcium, potassium:sodium antiporter activity
Q5A_RS22385	COG0517	IMP dehydrogenase activity
Q5A_RS22385	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Q5A_RS22390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Q5A_RS22395	COG3117	lipopolysaccharide transmembrane transporter activity
Q5A_RS22400	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Q5A_RS22405	COG1137	ATPase activity
Q5A_RS22410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Q5A_RS22425	COG1660	Displays ATPase and GTPase activities
Q5A_RS22430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Q5A_RS22435	COG2026	Addiction module toxin, RelE StbE family
Q5A_RS22445	COG3711	transcriptional antiterminator
Q5A_RS22445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Q5A_RS22450	COG2706	6-phosphogluconolactonase activity
Q5A_RS22465	COG3964	amidohydrolase
Q5A_RS22495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Q5A_RS22500	COG3783	Cytochrome b(562)
Q5A_RS22505	COG0312	modulator of DNA gyrase
Q5A_RS22510	COG3028	Belongs to the UPF0307 family
Q5A_RS22515	COG2732	(Barnase) inhibitor
Q5A_RS22525	COG1289	transmembrane transporter activity
Q5A_RS22530	COG1566	PFAM secretion protein HlyD family protein
Q5A_RS22540	COG0583	DNA-binding transcription factor activity
Q5A_RS22555	COG3210	domain, Protein
Q5A_RS22610	COG0312	modulator of DNA gyrase
Q5A_RS22615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Q5A_RS22620	COG3164	Protein of unknown function
Q5A_RS22625	COG1530	ribonuclease E activity
Q5A_RS22630	COG0424	maF-like protein
Q5A_RS22635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Q5A_RS22640	COG1792	Involved in formation and maintenance of cell shape
Q5A_RS22645	COG1077	Cell shape determining protein MreB Mrl
Q5A_RS22650	COG2199	diguanylate cyclase activity
Q5A_RS22650	COG2200	EAL domain
Q5A_RS22655	COG0604	alcohol dehydrogenase
Q5A_RS22660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Q5A_RS22665	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Q5A_RS22670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Q5A_RS22675	COG0511	ligase activity, forming carbon-carbon bonds
Q5A_RS22680	COG0439	Biotin carboxylase
Q5A_RS22685	COG3385	transposase activity
Q5A_RS22690	COG3924	membrane
Q5A_RS22695	COG4145	pantothenate transmembrane transporter activity
Q5A_RS22700	COG2264	protein methyltransferase activity
Q5A_RS22720	COG1560	Kdo2-lipid A biosynthetic process
Q5A_RS22735	COG1380	Effector of murein hydrolase LrgA
Q5A_RS22740	COG0583	DNA-binding transcription factor activity
Q5A_RS22750	COG0025	NhaP-type Na H and K H
Q5A_RS22755	COG2252	PERMEase
Q5A_RS22765	COG0625	glutathione transferase activity
Q5A_RS22780	COG0583	DNA-binding transcription factor activity
Q5A_RS22785	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS22795	COG0629	single-stranded DNA binding
Q5A_RS22800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Q5A_RS22805	COG1064	alcohol dehydrogenase
Q5A_RS22810	COG0110	maltose O-acetyltransferase activity
Q5A_RS22815	COG2315	Protein conserved in bacteria
Q5A_RS22825	COG1448	Aminotransferase
Q5A_RS22835	COG1522	sequence-specific DNA binding
Q5A_RS22840	COG1113	amino acid transport
Q5A_RS22860	COG0604	alcohol dehydrogenase
Q5A_RS22870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Q5A_RS22880	COG1595	DNA-templated transcription, initiation
Q5A_RS22890	COG0735	belongs to the Fur family
Q5A_RS22895	COG3237	CsbD-like
Q5A_RS22900	COG0534	Mate efflux family protein
Q5A_RS22905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Q5A_RS22910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Q5A_RS22915	COG2937	Belongs to the GPAT DAPAT family
Q5A_RS22920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Q5A_RS22925	COG3161	chorismate lyase activity
Q5A_RS22940	COG4580	involved in the transport of maltose and maltodextrins
Q5A_RS22950	COG0366	Alpha amylase catalytic
Q5A_RS22955	COG2182	Extracellular solute-binding protein
Q5A_RS22960	COG1175	transmembrane transport
Q5A_RS22965	COG3833	ABC-type maltose transport systems, permease component
Q5A_RS22970	COG3223	Belongs to the PsiE family
Q5A_RS22980	COG0166	Belongs to the GPI family
Q5A_RS22990	COG0527	aspartate kinase activity
Q5A_RS23000	COG1283	sodium-dependent phosphate transmembrane transporter activity
Q5A_RS23005	COG3842	ATPase activity
Q5A_RS23015	COG4149	molybdate abc transporter
Q5A_RS23030	COG2188	Transcriptional regulator
Q5A_RS23040	COG1414	Transcriptional regulator
Q5A_RS23045	COG3265	gluconokinase activity
Q5A_RS23050	COG2610	gluconate transmembrane transporter activity
Q5A_RS23055	COG0129	dihydroxy-acid dehydratase activity
Q5A_RS23060	COG0800	Aldolase
Q5A_RS23065	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Q5A_RS23070	COG2224	Isocitrate lyase
Q5A_RS23075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Q5A_RS23080	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Q5A_RS23120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Q5A_RS23125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Q5A_RS23130	COG0009	L-threonylcarbamoyladenylate synthase
Q5A_RS23135	COG0551	DNA topoisomerase type I activity
Q5A_RS23140	COG2922	Belongs to the Smg family
Q5A_RS23145	COG0758	DNA mediated transformation
Q5A_RS23150	COG0242	peptide deformylase activity
Q5A_RS23155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Q5A_RS23160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Q5A_RS23160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Q5A_RS23165	COG0569	domain protein
Q5A_RS23170	COG1970	mechanosensitive ion channel activity
Q5A_RS23175	COG3036	rescue of stalled ribosome
Q5A_RS23180	COG0789	Transcriptional regulator
Q5A_RS23190	COG0203	ribosomal protein L17
Q5A_RS23195	COG0202	RNA polymerase activity
Q5A_RS23200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Q5A_RS23205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Q5A_RS23210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Q5A_RS23215	COG0201	protein transport
Q5A_RS23230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Q5A_RS23250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Q5A_RS23255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Q5A_RS23260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Q5A_RS23265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Q5A_RS23295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Q5A_RS23305	COG0089	rRNA binding
Q5A_RS23310	COG0088	Forms part of the polypeptide exit tunnel
Q5A_RS23315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Q5A_RS23320	COG0051	transcription antitermination factor activity, RNA binding
Q5A_RS23330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Q5A_RS23335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Q5A_RS23340	COG0049	tRNA binding
Q5A_RS23345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Q5A_RS23350	COG2168	tRNA wobble position uridine thiolation
Q5A_RS23355	COG2923	Belongs to the DsrF TusC family
Q5A_RS23360	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Q5A_RS23365	COG2964	Protein conserved in bacteria
Q5A_RS23370	COG0545	Peptidyl-prolyl cis-trans isomerase
Q5A_RS23375	COG2900	Belongs to the SlyX family
Q5A_RS23380	COG1047	Peptidyl-prolyl cis-trans
Q5A_RS23385	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
Q5A_RS23395	COG2249	NAD(P)H dehydrogenase (quinone) activity
Q5A_RS23400	COG0488	(ABC) transporter
Q5A_RS23405	COG2175	clavaminate synthase activity
Q5A_RS23410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Q5A_RS23420	COG4521	taurine ABC transporter
Q5A_RS23425	COG0673	inositol 2-dehydrogenase activity
Q5A_RS23440	COG2211	Major facilitator Superfamily
Q5A_RS23465	COG0429	hydrolase of the alpha beta-hydrolase fold
Q5A_RS23470	COG3089	Belongs to the UPF0270 family
Q5A_RS23475	COG3954	Phosphoribulokinase
Q5A_RS23480	COG1765	OsmC-like protein
Q5A_RS23485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Q5A_RS23490	COG1289	transmembrane transporter activity
Q5A_RS23510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Q5A_RS23515	COG0433	COG0433 Predicted ATPase
Q5A_RS23535	COG3275	phosphorelay sensor kinase activity
Q5A_RS23540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Q5A_RS23545	COG1447	Phosphotransferase system cellobiose-specific component IIA
Q5A_RS23550	COG1486	melibiose metabolic process
Q5A_RS23555	COG1609	Transcriptional regulator
Q5A_RS23560	COG0738	Major facilitator superfamily
Q5A_RS23570	COG0402	S-adenosylhomocysteine deaminase activity
Q5A_RS23575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Q5A_RS23590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Q5A_RS23590	COG1648	precorrin-2 dehydrogenase activity
Q5A_RS23595	COG0180	Tryptophanyl-tRNA synthetase
Q5A_RS23600	COG0546	phosphoglycolate phosphatase activity
Q5A_RS23620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Q5A_RS23625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Q5A_RS23630	COG4796	Type ii and iii secretion system protein
Q5A_RS23655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Q5A_RS23660	COG0494	nUDIX hydrolase
Q5A_RS23670	COG1011	Hydrolase
Q5A_RS23675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Q5A_RS23680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Q5A_RS23710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Q5A_RS23715	COG2183	response to ionizing radiation
Q5A_RS23720	COG1918	ferrous iron import across plasma membrane
Q5A_RS23740	COG2267	carboxylic ester hydrolase activity
Q5A_RS23745	COG1040	competence protein
Q5A_RS23750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Q5A_RS23750	COG0316	Belongs to the HesB IscA family
Q5A_RS23755	COG1640	4-alpha-glucanotransferase
Q5A_RS23760	COG0058	SHG alpha-glucan phosphorylase activity
Q5A_RS23765	COG2909	trisaccharide binding
Q5A_RS23770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Q5A_RS23775	COG2271	Major facilitator Superfamily
Q5A_RS23780	COG2731	YhcH YjgK YiaL family protein
Q5A_RS23785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Q5A_RS23790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Q5A_RS23795	COG0705	Rhomboid family
Q5A_RS23800	COG1349	DNA-binding transcription factor activity
Q5A_RS23810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Q5A_RS23815	COG0058	SHG alpha-glucan phosphorylase activity
Q5A_RS23820	COG0297	glycogen (starch) synthase activity
Q5A_RS23825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Q5A_RS23830	COG1523	belongs to the glycosyl hydrolase 13 family
Q5A_RS23835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Q5A_RS23850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Q5A_RS23855	COG2095	MarC family integral membrane protein
Q5A_RS23860	COG3265	gluconokinase activity
Q5A_RS23865	COG2610	gluconate transmembrane transporter activity
Q5A_RS23870	COG1609	Transcriptional regulator
Q5A_RS23875	COG1741	Belongs to the pirin family
Q5A_RS23880	COG1247	-acetyltransferase
Q5A_RS23885	COG3191	aminopeptidase activity
Q5A_RS23890	COG1082	Xylose isomerase domain protein TIM barrel
Q5A_RS23895	COG1082	Xylose isomerase domain protein TIM barrel
Q5A_RS23900	COG0673	inositol 2-dehydrogenase activity
Q5A_RS23905	COG3962	Belongs to the TPP enzyme family
Q5A_RS23915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Q5A_RS23935	COG3718	enzyme involved in inositol metabolism
Q5A_RS23945	COG2814	Major facilitator Superfamily
Q5A_RS23945	COG0477	Major facilitator Superfamily
Q5A_RS23955	COG0390	transport system, permease component
Q5A_RS23960	COG4619	ABC transporter
Q5A_RS23990	COG3121	Chaperone
Q5A_RS23995	COG3539	Fimbrial protein
Q5A_RS24015	COG2197	response regulator
Q5A_RS24030	COG2081	HI0933 family
Q5A_RS24035	COG0306	phosphate transporter
Q5A_RS24045	COG0589	response to stress
Q5A_RS24060	COG1129	ABC transporter
Q5A_RS24065	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS24070	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS24080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Q5A_RS24080	COG0517	IMP dehydrogenase activity
Q5A_RS24085	COG0742	ribosomal rna small subunit methyltransferase
Q5A_RS24090	COG0339	signal peptide processing
Q5A_RS24105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Q5A_RS24110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Q5A_RS24115	COG2318	DinB family
Q5A_RS24135	COG4977	sequence-specific DNA binding
Q5A_RS24160	COG2205	protein histidine kinase activity
Q5A_RS24160	COG0784	Response regulator, receiver
Q5A_RS24185	COG5441	Belongs to the UPF0261 family
Q5A_RS24190	COG3678	ATP-independent chaperone mediated protein folding
Q5A_RS24195	COG5001	Diguanylate cyclase
Q5A_RS24200	COG1024	Enoyl-CoA hydratase
Q5A_RS24215	COG1295	ribonuclease BN
Q5A_RS24220	COG0477	Major facilitator Superfamily
Q5A_RS24225	COG2134	cdp-diacylglycerol pyrophosphatase
Q5A_RS24230	COG2982	Protein involved in outer membrane biogenesis
Q5A_RS24235	COG1942	4-Oxalocrotonate Tautomerase
Q5A_RS24240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Q5A_RS24245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Q5A_RS24250	COG0583	DNA-binding transcription factor activity
Q5A_RS24260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Q5A_RS24265	COG0129	dihydroxy-acid dehydratase activity
Q5A_RS24270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Q5A_RS24275	COG3978	acetolactate synthase activity
Q5A_RS24285	COG2814	Major facilitator Superfamily
Q5A_RS24290	COG0606	chelatase, subunit chli
Q5A_RS24295	COG3085	chromosome segregation
Q5A_RS24300	COG0583	DNA-binding transcription factor activity
Q5A_RS24305	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS24310	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS24315	COG1129	ABC transporter
Q5A_RS24320	COG1879	ABC-type sugar transport system periplasmic component
Q5A_RS24360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Q5A_RS24365	COG4206	TonB-dependent receptor
Q5A_RS24370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Q5A_RS24385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Q5A_RS24395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Q5A_RS24395	COG0678	peroxiredoxin activity
Q5A_RS24400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Q5A_RS24405	COG0165	Argininosuccinate lyase
Q5A_RS24410	COG0137	argininosuccinate synthase activity
Q5A_RS24415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Q5A_RS24430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Q5A_RS24450	COG0460	homoserine dehydrogenase
Q5A_RS24450	COG0527	aspartate kinase activity
Q5A_RS24455	COG0626	cystathionine gamma-synthase activity
Q5A_RS24460	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
Q5A_RS24465	COG0254	rRNA binding
Q5A_RS24470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Q5A_RS24475	COG1609	Transcriptional regulator
Q5A_RS24480	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Q5A_RS24485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Q5A_RS24490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Q5A_RS24495	COG1575	Belongs to the MenA family. Type 1 subfamily
Q5A_RS24500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Q5A_RS24505	COG3074	FtsZ-dependent cytokinesis
Q5A_RS24510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Q5A_RS24520	COG1494	fructose-1,6-bisphosphatase
Q5A_RS24525	COG2814	Major facilitator Superfamily
Q5A_RS24540	COG3152	Membrane
Q5A_RS24550	COG0149	triose-phosphate isomerase activity
Q5A_RS24560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Q5A_RS24565	COG0205	6-phosphofructokinase activity
Q5A_RS24570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Q5A_RS24575	COG3678	ATP-independent chaperone mediated protein folding
Q5A_RS24580	COG0745	RESPONSE REGULATOR receiver
Q5A_RS24585	COG2205	protein histidine kinase activity
Q5A_RS24590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Q5A_RS24605	COG1045	serine acetyltransferase
Q5A_RS24610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Q5A_RS24615	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Q5A_RS24620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Q5A_RS24625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Q5A_RS24630	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Q5A_RS24635	COG4942	peptidase
Q5A_RS24640	COG2861	carbohydrate metabolic process
Q5A_RS24655	COG0156	8-amino-7-oxononanoate synthase activity
Q5A_RS24660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Q5A_RS24665	COG0859	PFAM glycosyl transferase family 9
Q5A_RS24670	COG0859	PFAM glycosyl transferase family 9
Q5A_RS24690	COG0859	PFAM glycosyl transferase family 9
Q5A_RS24700	COG0859	PFAM glycosyl transferase family 9
Q5A_RS24705	COG0438	transferase activity, transferring glycosyl groups
Q5A_RS24710	COG0438	transferase activity, transferring glycosyl groups
Q5A_RS24720	COG1519	Transferase
Q5A_RS24735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Q5A_RS24745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Q5A_RS24750	COG2003	Belongs to the UPF0758 family
Q5A_RS24755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Q5A_RS24760	COG0756	dUTP diphosphatase activity
Q5A_RS24765	COG1309	transcriptional regulator
Q5A_RS24770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Q5A_RS24775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Q5A_RS24780	COG1561	YicC-like family, N-terminal region
Q5A_RS24790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Q5A_RS24800	COG2860	membrane
Q5A_RS24805	COG0583	DNA-binding transcription factor activity
Q5A_RS24815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Q5A_RS24820	COG0194	GDP metabolic process
Q5A_RS24825	COG1758	RNA polymerase activity
Q5A_RS24830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Q5A_RS24835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Q5A_RS24840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Q5A_RS24845	COG0786	glutamate:sodium symporter activity
Q5A_RS24850	COG2233	PERMEase
Q5A_RS24855	COG2982	Protein involved in outer membrane biogenesis
Q5A_RS24860	COG0456	acetyltransferase
Q5A_RS24865	COG1490	D-aminoacyl-tRNA deacylase activity
Q5A_RS24870	COG1295	ribonuclease BN
Q5A_RS24875	COG1011	Hydrolase
Q5A_RS24890	COG3852	Histidine kinase
Q5A_RS24905	COG3078	GTPase activator activity
Q5A_RS24915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Q5A_RS24920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Q5A_RS24920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Q5A_RS24925	COG0204	Acyl-transferase
Q5A_RS24930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Q5A_RS24935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Q5A_RS24940	COG3084	Protein conserved in bacteria
Q5A_RS24945	COG0746	molybdenum cofactor guanylyltransferase activity
Q5A_RS24950	COG1763	Mo-molybdopterin cofactor biosynthetic process
Q5A_RS24975	COG2186	Transcriptional regulator
Q5A_RS24980	COG0477	Major facilitator Superfamily
Q5A_RS24985	COG1609	Transcriptional regulator
Q5A_RS24990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Q5A_RS25000	COG1172	Belongs to the binding-protein-dependent transport system permease family
Q5A_RS25005	COG1129	ABC transporter
Q5A_RS25010	COG1869	D-ribose catabolic process
Q5A_RS25015	COG3158	transport of potassium into the cell
Q5A_RS25020	COG0714	Associated with various cellular activities
Q5A_RS25025	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Q5A_RS25030	COG2502	aspartate--ammonia ligase
Q5A_RS25035	COG1522	sequence-specific DNA binding
Q5A_RS25040	COG0716	FMN binding
Q5A_RS25045	COG0445	tRNA wobble uridine modification
Q5A_RS25050	COG0357	Ribosomal RNA small subunit methyltransferase G
Q5A_RS25055	COG3312	ion transport
Q5A_RS25070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Q5A_RS25075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Q5A_RS25080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Q5A_RS25085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Q5A_RS25090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Q5A_RS25095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Q5A_RS25100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Q5A_RS25110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Q5A_RS25115	COG0573	inorganic phosphate transmembrane transporter activity
Q5A_RS25120	COG0581	inorganic phosphate transmembrane transporter activity
Q5A_RS25135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Q5A_RS25140	COG0765	amino acid transport
Q5A_RS25145	COG0765	amino acid transport
Q5A_RS25150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Q5A_RS25155	COG2252	PERMEase
Q5A_RS25165	COG0431	NADPH-dependent FMN reductase
Q5A_RS25170	COG2091	lysine biosynthetic process via aminoadipic acid
Q5A_RS25175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Q5A_RS25180	COG0706	membrane insertase activity
Q5A_RS25185	COG0594	ribonuclease P activity
Q5A_RS25280	COG0564	pseudouridine synthase activity
Q5A_RS25325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Q5A_RS25335	COG0582	viral genome integration into host DNA
Q5A_RS25350	COG0582	viral genome integration into host DNA
Q5A_RS25370	COG0582	viral genome integration into host DNA
Q5A_RS25435	COG3130	regulation of translation
Q5A_RS25510	COG0538	isocitrate dehydrogenase activity
Q5A_RS25515	COG0538	isocitrate dehydrogenase activity
Q5A_RS25595	COG2814	Major facilitator Superfamily
Q5A_RS25685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Q5A_RS25715	COG2826	transposase and inactivated derivatives, IS30 family
Q5A_RS25810	COG2194	sulfuric ester hydrolase activity
Q5A_RS25885	COG1028	Short-chain dehydrogenase reductase Sdr
Q5A_RS25890	COG2197	response regulator
Q5A_RS25895	COG3539	Fimbrial protein
Q5A_RS25920	COG1396	sequence-specific DNA binding
Q5A_RS25940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Q5A_RS26010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Q5A_RS26015	COG0230	Belongs to the bacterial ribosomal protein bL34 family