locus-tag	class	description
M621_RS25165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M621_RS25170	COG0592	DNA-directed DNA polymerase activity
M621_RS25175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M621_RS25180	COG0187	DNA topoisomerase II activity
M621_RS25185	COG0561	phosphatase activity
M621_RS25190	COG2423	ornithine cyclodeaminase activity
M621_RS25195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M621_RS25200	COG0823	Involved in the tonB-independent uptake of proteins
M621_RS25205	COG5645	(Lipo)protein
M621_RS25210	COG0071	Belongs to the small heat shock protein (HSP20) family
M621_RS25215	COG0071	Belongs to the small heat shock protein (HSP20) family
M621_RS25220	COG2985	domain, Protein
M621_RS25225	COG3977	Valine--pyruvate aminotransferase
M621_RS25230	COG0366	Alpha amylase catalytic
M621_RS25235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M621_RS25240	COG2271	Major facilitator Superfamily
M621_RS25245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M621_RS25255	COG1609	Transcriptional regulator
M621_RS25260	COG2885	chlorophyll binding
M621_RS25265	COG0456	acetyltransferase
M621_RS25270	COG2818	Glycosylase
M621_RS25280	COG2771	luxR family
M621_RS25290	COG2271	Major facilitator Superfamily
M621_RS25295	COG0752	glycyl-tRNA synthetase alpha subunit
M621_RS25300	COG0751	glycine-tRNA ligase activity
M621_RS25315	COG2213	PTS system mannitol-specific
M621_RS25315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M621_RS25320	COG0246	Mannitol dehydrogenase
M621_RS25325	COG3722	fumarate hydratase activity
M621_RS25335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M621_RS25350	COG2258	MOSC domain
M621_RS25360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M621_RS25370	COG3383	formate dehydrogenase (NAD+) activity
M621_RS25370	COG0243	molybdopterin cofactor binding
M621_RS25375	COG0243	molybdopterin cofactor binding
M621_RS25375	COG3383	formate dehydrogenase (NAD+) activity
M621_RS25380	COG0437	4 iron, 4 sulfur cluster binding
M621_RS25385	COG2864	formate dehydrogenase
M621_RS25390	COG3058	Necessary for formate dehydrogenase activity
M621_RS25400	COG0625	glutathione transferase activity
M621_RS25405	COG1921	L-seryl-tRNASec selenium transferase activity
M621_RS25410	COG3276	selenocysteine insertion sequence binding
M621_RS25420	COG3274	enterobacterial common antigen metabolic process
M621_RS25430	COG1335	isochorismatase
M621_RS25435	COG0402	S-adenosylhomocysteine deaminase activity
M621_RS25440	COG1070	Carbohydrate kinase
M621_RS25445	COG2115	Belongs to the xylose isomerase family
M621_RS25450	COG4213	ABC transporter substrate-binding protein
M621_RS25455	COG1129	ABC transporter
M621_RS25460	COG4214	carbohydrate transport
M621_RS25465	COG2207	Transcriptional regulator
M621_RS25465	COG1609	Transcriptional regulator
M621_RS25470	COG0583	DNA-binding transcription factor activity
M621_RS25475	COG2807	transmembrane transport
M621_RS25500	COG5001	Diguanylate cyclase
M621_RS25500	COG3447	MASE1 domain protein
M621_RS25500	COG5002	protein histidine kinase activity
M621_RS25530	COG2814	Major facilitator Superfamily
M621_RS25535	COG0583	DNA-binding transcription factor activity
M621_RS25555	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS25580	COG1846	Transcriptional regulator
M621_RS25585	COG1764	response to oxidative stress
M621_RS25590	COG2194	sulfuric ester hydrolase activity
M621_RS25595	COG2197	response regulator
M621_RS25605	COG2271	Major facilitator Superfamily
M621_RS25620	COG0747	negative chemotaxis
M621_RS25625	COG0601	transmembrane transport
M621_RS25630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M621_RS25635	COG0444	Belongs to the ABC transporter superfamily
M621_RS25640	COG4608	Belongs to the ABC transporter superfamily
M621_RS25645	COG2194	sulfuric ester hydrolase activity
M621_RS25670	COG1215	transferase activity, transferring glycosyl groups
M621_RS25675	COG1215	transferase activity, transferring glycosyl groups
M621_RS25680	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M621_RS25685	COG0457	Tetratricopeptide repeat
M621_RS25685	COG3118	belongs to the thioredoxin family
M621_RS25690	COG2200	EAL domain
M621_RS25690	COG2199	diguanylate cyclase activity
M621_RS25695	COG1301	dicarboxylic acid transport
M621_RS25700	COG0612	Peptidase, M16
M621_RS25705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M621_RS25715	COG0248	Ppx GppA phosphatase
M621_RS25720	COG0513	Belongs to the DEAD box helicase family
M621_RS25725	COG3118	belongs to the thioredoxin family
M621_RS25730	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M621_RS25735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M621_RS25745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M621_RS25750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M621_RS25755	COG1088	dTDP-glucose 4,6-dehydratase activity
M621_RS25760	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M621_RS25765	COG0456	acetyltransferase
M621_RS25770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M621_RS25775	COG2244	polysaccharide biosynthetic process
M621_RS25780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M621_RS25790	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M621_RS25820	COG3071	HemY protein
M621_RS25825	COG2959	enzyme of heme biosynthesis
M621_RS25835	COG0181	hydroxymethylbilane synthase activity
M621_RS25840	COG3072	Adenylate cyclase
M621_RS25845	COG1965	Belongs to the frataxin family
M621_RS25850	COG5567	small periplasmic lipoprotein
M621_RS25855	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M621_RS25860	COG3159	Protein conserved in bacteria
M621_RS25870	COG1011	Hydrolase
M621_RS25875	COG0210	DNA helicase
M621_RS25890	COG3180	Ammonia monooxygenase
M621_RS25900	COG2050	protein possibly involved in aromatic compounds catabolism
M621_RS25905	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M621_RS25915	COG1280	lysine exporter protein (LysE YggA)
M621_RS25920	COG1280	lysine exporter protein (LysE YggA)
M621_RS25925	COG2267	carboxylic ester hydrolase activity
M621_RS25930	COG0561	phosphatase activity
M621_RS25935	COG0584	glycerophosphoryl diester phosphodiesterase
M621_RS25940	COG2271	Major facilitator Superfamily
M621_RS25945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M621_RS25955	COG0247	lactate metabolic process
M621_RS25970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M621_RS25975	COG0425	Belongs to the sulfur carrier protein TusA family
M621_RS25980	COG2217	Heavy metal translocating P-type atpase
M621_RS25995	COG3714	YhhN family
M621_RS26005	COG3776	membrane
M621_RS26010	COG0742	ribosomal rna small subunit methyltransferase
M621_RS26015	COG0552	protein localization to endoplasmic reticulum
M621_RS26020	COG2884	Cell division ATP-binding protein ftsE
M621_RS26025	COG2177	Part of the ABC transporter FtsEX involved in
M621_RS26045	COG0456	acetyltransferase
M621_RS26055	COG0559	Belongs to the binding-protein-dependent transport system permease family
M621_RS26060	COG4177	L-phenylalanine transmembrane transporter activity
M621_RS26070	COG0410	ABC transporter
M621_RS26075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M621_RS26080	COG1653	transport
M621_RS26085	COG1175	transmembrane transport
M621_RS26095	COG3842	ATPase activity
M621_RS26100	COG0584	glycerophosphoryl diester phosphodiesterase
M621_RS26120	COG0583	DNA-binding transcription factor activity
M621_RS26125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M621_RS26130	COG0412	Dienelactone hydrolase
M621_RS26140	COG0586	Pfam SNARE associated Golgi protein
M621_RS26145	COG1322	Protein conserved in bacteria
M621_RS26150	COG2226	methyltransferase
M621_RS26155	COG3165	ubiquinone biosynthetic process from chorismate
M621_RS26160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M621_RS26165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M621_RS26175	COG0805	protein transport
M621_RS26180	COG0084	hydrolase, TatD family'
M621_RS26210	COG0183	Belongs to the thiolase family
M621_RS26215	COG1024	Enoyl-CoA hydratase
M621_RS26215	COG1250	3-hydroxyacyl-CoA dehydrogenase
M621_RS26220	COG2271	Major facilitator Superfamily
M621_RS26225	COG0006	proline dipeptidase activity
M621_RS26230	COG1739	Uncharacterized protein family UPF0029
M621_RS26235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M621_RS26265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M621_RS26270	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M621_RS26270	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M621_RS26275	COG1072	(Pantothenic acid kinase))
M621_RS26305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M621_RS26315	COG0250	Participates in transcription elongation, termination and antitermination
M621_RS26320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M621_RS26325	COG0081	regulation of translation
M621_RS26330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M621_RS26335	COG0222	ribosome binding
M621_RS26340	COG0085	RNA polymerase activity
M621_RS26345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M621_RS26360	COG2022	thiamine diphosphate biosynthetic process
M621_RS26365	COG2104	thiamine diphosphate biosynthetic process
M621_RS26370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M621_RS26375	COG0352	thiamine-phosphate diphosphorylase activity
M621_RS26385	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
M621_RS26390	COG2816	NAD+ diphosphatase activity
M621_RS26395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M621_RS26400	COG1515	deoxyribonuclease V activity
M621_RS26420	COG0151	Belongs to the GarS family
M621_RS26425	COG0138	bifunctional purine biosynthesis protein purh
M621_RS26460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M621_RS26465	COG3162	membrane
M621_RS26470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M621_RS26475	COG1301	dicarboxylic acid transport
M621_RS26480	COG0288	reversible hydration of carbon dioxide
M621_RS26485	COG0659	secondary active sulfate transmembrane transporter activity
M621_RS26490	COG0583	DNA-binding transcription factor activity
M621_RS26495	COG3366	ferrous iron transmembrane transporter activity
M621_RS26500	COG0700	Nucleoside recognition
M621_RS26505	COG1473	amidohydrolase
M621_RS26515	COG1309	transcriptional regulator
M621_RS26520	COG4232	protein-disulfide reductase activity
M621_RS26530	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M621_RS26545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M621_RS26550	COG0459	protein refolding
M621_RS26575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M621_RS26580	COG5510	response to toxic substance
M621_RS26585	COG5510	response to toxic substance
M621_RS26600	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M621_RS26605	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M621_RS26610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M621_RS26615	COG1053	succinate dehydrogenase
M621_RS26620	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M621_RS26625	COG1511	domain protein
M621_RS26625	COG3264	Mechanosensitive ion channel
M621_RS26630	COG0688	phosphatidylethanolamine metabolic process
M621_RS26635	COG1162	GTPase activity
M621_RS26640	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M621_RS26660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M621_RS26665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M621_RS26665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M621_RS26670	COG0802	atpase or kinase
M621_RS26675	COG0860	N-Acetylmuramoyl-L-alanine amidase
M621_RS26680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M621_RS26685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M621_RS26690	COG1923	regulation of RNA biosynthetic process
M621_RS26695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M621_RS26700	COG0330	HflC and HflK could
M621_RS26705	COG0330	HflC and HflK could
M621_RS26710	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M621_RS26715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M621_RS26720	COG1959	2 iron, 2 sulfur cluster binding
M621_RS26725	COG0557	exoribonuclease II activity
M621_RS26730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M621_RS26735	COG1960	acyl-CoA dehydrogenase activity
M621_RS26740	COG3766	membrane
M621_RS26750	COG3650	response to hydrogen peroxide
M621_RS26755	COG1073	alpha beta
M621_RS26765	COG0360	Binds together with S18 to 16S ribosomal RNA
M621_RS26770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M621_RS26775	COG0359	binds to the 23S rRNA
M621_RS26785	COG3061	Opacity-associated protein A
M621_RS26790	COG0545	Peptidyl-prolyl cis-trans isomerase
M621_RS26800	COG0737	Belongs to the 5'-nucleotidase family
M621_RS26805	COG1218	3'(2'),5'-bisphosphate nucleotidase
M621_RS26810	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M621_RS26820	COG1253	flavin adenine dinucleotide binding
M621_RS26825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M621_RS26830	COG0729	surface antigen
M621_RS26835	COG2911	Protein conserved in bacteria
M621_RS26840	COG2105	PFAM AIG2 family protein
M621_RS26845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M621_RS26850	COG0840	transmembrane signaling receptor activity
M621_RS26855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M621_RS26860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M621_RS26875	COG1438	arginine binding
M621_RS26880	COG0039	L-malate dehydrogenase activity
M621_RS26885	COG3423	Transcriptional regulator
M621_RS26895	COG0142	geranyltranstransferase activity
M621_RS26900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M621_RS26905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M621_RS26910	COG0697	spore germination
M621_RS26915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M621_RS26920	COG0642	Histidine kinase
M621_RS26925	COG0745	RESPONSE REGULATOR receiver
M621_RS26930	COG2027	D-alanyl-D-alanine carboxypeptidase
M621_RS26940	COG1534	Rna-binding protein
M621_RS26945	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M621_RS26955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M621_RS26960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M621_RS26965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M621_RS26980	COG0779	Required for maturation of 30S ribosomal subunits
M621_RS26985	COG0195	Participates in both transcription termination and antitermination
M621_RS26990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M621_RS26995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M621_RS27000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M621_RS27005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M621_RS27010	COG1185	polyribonucleotide nucleotidyltransferase activity
M621_RS27020	COG0513	Belongs to the DEAD box helicase family
M621_RS27025	COG2391	methyltransferase activity
M621_RS27030	COG0425	Belongs to the sulfur carrier protein TusA family
M621_RS27040	COG0477	Major facilitator Superfamily
M621_RS27045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS27080	COG0826	peptidase U32
M621_RS27085	COG0826	peptidase U32
M621_RS27090	COG3154	lipid carrier protein
M621_RS27095	COG3153	acetyltransferase
M621_RS27100	COG2827	Endonuclease containing a URI domain
M621_RS27105	COG3787	Belongs to the UPF0306 family
M621_RS27110	COG0702	epimerase
M621_RS27115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M621_RS27125	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M621_RS27130	COG3454	Phosphonate metabolism
M621_RS27135	COG4778	phosphonate C-P lyase system protein PhnL
M621_RS27140	COG4107	phosphonate C-P lyase system protein PhnK
M621_RS27145	COG3627	carbon phosphorus lyase activity
M621_RS27150	COG3626	phosphonate metabolism
M621_RS27155	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
M621_RS27160	COG3624	Phosphonate C-P lyase system protein PhnG
M621_RS27165	COG2188	Transcriptional regulator
M621_RS27170	COG0701	Predicted permease
M621_RS27185	COG0583	DNA-binding transcription factor activity
M621_RS27190	COG2249	NAD(P)H dehydrogenase (quinone) activity
M621_RS27195	COG0366	Alpha amylase catalytic
M621_RS27200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS27200	COG1263	PTS System
M621_RS27245	COG1609	Transcriptional regulator
M621_RS27250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M621_RS27275	COG2308	Evidence 4 Homologs of previously reported genes of
M621_RS27290	COG0540	Belongs to the ATCase OTCase family
M621_RS27300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M621_RS27305	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
M621_RS27315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M621_RS27325	COG0456	acetyltransferase
M621_RS27335	COG2927	DNA polymerase III (CHI subunit)
M621_RS27340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M621_RS27345	COG0795	lipopolysaccharide-transporting ATPase activity
M621_RS27350	COG0795	lipopolysaccharide-transporting ATPase activity
M621_RS27390	COG3550	peptidyl-serine autophosphorylation
M621_RS27395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M621_RS27400	COG1061	Type III restriction enzyme res subunit
M621_RS27405	COG1002	Type II restriction enzyme, methylase subunits
M621_RS27420	COG2723	6-phospho-beta-galactosidase activity
M621_RS27425	COG1263	PTS System
M621_RS27425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS27430	COG1609	Transcriptional regulator
M621_RS27445	COG0523	cobalamin synthesis protein
M621_RS27450	COG2879	small protein
M621_RS27455	COG1966	Carbon starvation protein
M621_RS27480	COG0174	glutamine synthetase
M621_RS27500	COG3391	amine dehydrogenase activity
M621_RS27505	COG2814	Major facilitator Superfamily
M621_RS27535	COG0318	PFAM AMP-dependent synthetase and ligase
M621_RS27545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M621_RS27550	COG2207	Transcriptional regulator
M621_RS27555	COG2207	Transcriptional regulator
M621_RS27555	COG3708	Transcriptional regulator
M621_RS27560	COG1376	ErfK ybiS ycfS ynhG family protein
M621_RS27590	COG0811	peptide transport
M621_RS27625	COG1454	alcohol dehydrogenase
M621_RS27635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M621_RS27645	COG2267	carboxylic ester hydrolase activity
M621_RS27665	COG1113	amino acid transport
M621_RS27690	COG1846	Transcriptional regulator
M621_RS27705	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS27720	COG3971	2-oxopent-4-enoate hydratase activity
M621_RS27740	COG2368	4-hydroxyphenylacetate
M621_RS27745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M621_RS27750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M621_RS27760	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS27765	COG0179	Fumarylacetoacetate (FAA) hydrolase
M621_RS27770	COG4948	Mandelate Racemase Muconate Lactonizing
M621_RS27775	COG3618	amidohydrolase
M621_RS27780	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS27785	COG3254	rhamnose metabolic process
M621_RS27790	COG0738	Major facilitator superfamily
M621_RS27795	COG2814	Major facilitator Superfamily
M621_RS27810	COG1309	transcriptional regulator
M621_RS27815	COG3706	GGDEF domain
M621_RS27845	COG0667	Aldo Keto reductase
M621_RS27850	COG2813	Specifically methylates the guanine in position
M621_RS27855	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
M621_RS27870	COG3550	peptidyl-serine autophosphorylation
M621_RS27875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M621_RS27880	COG2823	Periplasmic or secreted lipoprotein
M621_RS27885	COG3237	CsbD-like
M621_RS27890	COG4667	esterase of the alpha-beta hydrolase superfamily
M621_RS27895	COG0084	hydrolase, TatD family'
M621_RS27900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M621_RS27905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M621_RS27910	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M621_RS27915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M621_RS27925	COG3550	peptidyl-serine autophosphorylation
M621_RS27930	COG3726	membrane protein affecting hemolysin expression
M621_RS27935	COG0560	Phosphoserine phosphatase
M621_RS27950	COG0604	alcohol dehydrogenase
M621_RS27960	COG0488	(ABC) transporter
M621_RS27965	COG2885	chlorophyll binding
M621_RS27970	COG2199	diguanylate cyclase activity
M621_RS27980	COG0741	lytic transglycosylase activity
M621_RS27985	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M621_RS27990	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M621_RS27995	COG0406	alpha-ribazole phosphatase activity
M621_RS28000	COG3708	Transcriptional regulator
M621_RS28000	COG2207	Transcriptional regulator
M621_RS28005	COG3045	CreA protein
M621_RS28010	COG0745	RESPONSE REGULATOR receiver
M621_RS28025	COG0083	homoserine kinase activity
M621_RS28035	COG3022	response to hydroperoxide
M621_RS28040	COG1115	amino acid carrier protein
M621_RS28045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M621_RS28050	COG0521	Mo-molybdopterin cofactor biosynthetic process
M621_RS28060	COG1584	GPR1 FUN34 yaaH family protein
M621_RS28065	COG0443	Heat shock 70 kDa protein
M621_RS28070	COG0484	heat shock protein binding
M621_RS28075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M621_RS28080	COG0583	DNA-binding transcription factor activity
M621_RS28085	COG0268	Binds directly to 16S ribosomal RNA
M621_RS28090	COG0196	riboflavin kinase activity
M621_RS28095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M621_RS28100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M621_RS28105	COG1047	Peptidyl-prolyl cis-trans
M621_RS28110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M621_RS28135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M621_RS28140	COG0505	Belongs to the CarA family
M621_RS28145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M621_RS28155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M621_RS28155	COG0475	glutathione-regulated potassium exporter activity
M621_RS28165	COG2966	Psort location CytoplasmicMembrane, score
M621_RS28175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M621_RS28185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M621_RS28190	COG2967	ApaG domain
M621_RS28195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M621_RS28200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M621_RS28210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M621_RS28220	COG0564	pseudouridine synthase activity
M621_RS28225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M621_RS28230	COG0417	DNA replication proofreading
M621_RS28235	COG0586	Pfam SNARE associated Golgi protein
M621_RS28240	COG0440	acetolactate synthase activity
M621_RS28245	COG0028	Belongs to the TPP enzyme family
M621_RS28255	COG1178	ABC-type Fe3 transport system permease component
M621_RS28260	COG4143	(ABC) transporter
M621_RS28275	COG2814	Major facilitator Superfamily
M621_RS28280	COG0471	metal ion transport
M621_RS28285	COG0066	3-isopropylmalate dehydratase activity
M621_RS28290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M621_RS28295	COG0473	3-isopropylmalate dehydrogenase activity
M621_RS28300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M621_RS28310	COG1022	Amp-dependent synthetase and ligase
M621_RS28315	COG0028	Belongs to the TPP enzyme family
M621_RS28335	COG2001	Belongs to the MraZ family
M621_RS28340	COG0275	rRNA processing
M621_RS28345	COG3116	cell division
M621_RS28350	COG0768	penicillin binding
M621_RS28355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M621_RS28360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M621_RS28365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M621_RS28375	COG0772	Belongs to the SEDS family
M621_RS28380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M621_RS28385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M621_RS28390	COG1181	Belongs to the D-alanine--D-alanine ligase family
M621_RS28395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M621_RS28400	COG0849	cell division
M621_RS28405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M621_RS28425	COG0653	protein targeting
M621_RS28430	COG0494	nUDIX hydrolase
M621_RS28435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M621_RS28440	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M621_RS28445	COG0237	dephospho-CoA kinase activity
M621_RS28450	COG0516	GMP reductase activity
M621_RS28455	COG1459	type II secretion system
M621_RS28460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M621_RS28465	COG4969	Belongs to the N-Me-Phe pilin family
M621_RS28475	COG3023	N-Acetylmuramoyl-L-alanine amidase
M621_RS28480	COG3725	Membrane protein required for beta-lactamase induction
M621_RS28485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M621_RS28495	COG0316	Belongs to the HesB IscA family
M621_RS28500	COG2860	membrane
M621_RS28510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M621_RS28515	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M621_RS28520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M621_RS28525	COG3835	regulator
M621_RS28530	COG2721	sulfolactate sulfo-lyase activity
M621_RS28535	COG2271	Major facilitator Superfamily
M621_RS28540	COG4948	Mandelate Racemase Muconate Lactonizing
M621_RS28545	COG4948	Mandelate Racemase Muconate Lactonizing
M621_RS28550	COG3836	Belongs to the HpcH HpaI aldolase family
M621_RS28555	COG2084	Dehydrogenase
M621_RS28560	COG1929	Belongs to the glycerate kinase type-1 family
M621_RS28570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M621_RS28575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M621_RS28580	COG3956	TIGRFAM MazG family protein
M621_RS28585	COG0504	CTP synthase activity
M621_RS28615	COG2986	histidine ammonia-lyase
M621_RS28620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M621_RS28625	COG2271	Major facilitator Superfamily
M621_RS28630	COG0602	queuosine metabolic process
M621_RS28635	COG0720	synthase
M621_RS28640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M621_RS28645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M621_RS28650	COG0175	sulfate reduction
M621_RS28655	COG2234	aminopeptidase activity
M621_RS28660	COG1648	precorrin-2 dehydrogenase activity
M621_RS28660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M621_RS28665	COG0175	sulfate reduction
M621_RS28670	COG2895	sulfate adenylyltransferase (ATP) activity
M621_RS28675	COG0529	Catalyzes the synthesis of activated sulfate
M621_RS28690	COG0765	amino acid transport
M621_RS28700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M621_RS28705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M621_RS28710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M621_RS28715	COG0585	pseudouridine synthase activity
M621_RS28720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M621_RS28725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M621_RS28730	COG4942	peptidase
M621_RS28730	COG1388	LysM domain
M621_RS28735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M621_RS28740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M621_RS28775	COG0631	protein serine/threonine phosphatase activity
M621_RS28795	COG1396	sequence-specific DNA binding
M621_RS28810	COG2003	Belongs to the UPF0758 family
M621_RS28815	COG4974	Belongs to the 'phage' integrase family
M621_RS28875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M621_RS28880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M621_RS28885	COG2723	6-phospho-beta-galactosidase activity
M621_RS28890	COG1917	Cupin 2, conserved barrel domain protein
M621_RS28890	COG2169	Transcriptional regulator
M621_RS28910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M621_RS28915	COG2137	regulation of response to DNA damage stimulus
M621_RS28920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M621_RS28925	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M621_RS28950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M621_RS28955	COG1238	metal cluster binding
M621_RS28960	COG2918	glutathione biosynthetic process
M621_RS28965	COG1854	S-ribosylhomocysteine lyase activity
M621_RS28970	COG4536	flavin adenine dinucleotide binding
M621_RS28975	COG4137	Cytochrome C assembly protein
M621_RS28980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M621_RS28985	COG0228	four-way junction DNA binding
M621_RS28990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M621_RS28995	COG0336	Belongs to the RNA methyltransferase TrmD family
M621_RS29000	COG0335	large ribosomal subunit rRNA binding
M621_RS29045	COG5301	cellulose 1,4-beta-cellobiosidase activity
M621_RS29125	COG3137	Salt-induced outer membrane protein
M621_RS29130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M621_RS29135	COG1605	Chorismate mutase
M621_RS29135	COG0287	Prephenate dehydrogenase
M621_RS29140	COG0077	Prephenate dehydratase
M621_RS29140	COG1605	Chorismate mutase
M621_RS29145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M621_RS29150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M621_RS29155	COG0564	pseudouridine synthase activity
M621_RS29165	COG0542	response to heat
M621_RS29215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M621_RS29260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M621_RS29265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M621_RS29270	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS29275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M621_RS29280	COG0656	L-ascorbic acid biosynthetic process
M621_RS29285	COG0583	DNA-binding transcription factor activity
M621_RS29290	COG2814	Major facilitator Superfamily
M621_RS29300	COG0741	lytic transglycosylase activity
M621_RS29300	COG1388	LysM domain
M621_RS29305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M621_RS29310	COG2226	methyltransferase
M621_RS29315	COG0328	RNA-DNA hybrid ribonuclease activity
M621_RS29320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M621_RS29330	COG1953	Uracil, thiamine, allantoin
M621_RS29420	COG0765	amino acid transport
M621_RS29425	COG1126	abc transporter atp-binding protein
M621_RS29430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M621_RS29450	COG2233	PERMEase
M621_RS29460	COG0436	Aminotransferase
M621_RS29465	COG0235	Class ii aldolase
M621_RS29470	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
M621_RS29475	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M621_RS29480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M621_RS29485	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
M621_RS29500	COG1960	acyl-CoA dehydrogenase activity
M621_RS29505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M621_RS29510	COG0121	glutamine amidotransferase
M621_RS29515	COG3034	peptidoglycan biosynthetic process
M621_RS29520	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M621_RS29525	COG1805	sodium ion transport
M621_RS29530	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M621_RS29535	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M621_RS29540	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M621_RS29545	COG2871	sodium ion transport
M621_RS29550	COG1477	protein flavinylation
M621_RS29555	COG2991	Protein conserved in bacteria
M621_RS29560	COG0584	glycerophosphoryl diester phosphodiesterase
M621_RS29565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M621_RS29570	COG2195	Cleaves the N-terminal amino acid of tripeptides
M621_RS29575	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M621_RS29580	COG1073	alpha beta
M621_RS29590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M621_RS29620	COG3038	cytochrome b561
M621_RS29625	COG0747	negative chemotaxis
M621_RS29635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M621_RS29635	COG3433	isochorismatase activity
M621_RS29635	COG2226	methyltransferase
M621_RS29640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M621_RS29645	COG4774	siderophore transport
M621_RS29645	COG1629	transport
M621_RS29650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M621_RS29655	COG3391	amine dehydrogenase activity
M621_RS29670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M621_RS29675	COG2207	Transcriptional regulator
M621_RS29680	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS29715	COG0583	DNA-binding transcription factor activity
M621_RS29720	COG3961	Belongs to the TPP enzyme family
M621_RS29745	COG1349	DNA-binding transcription factor activity
M621_RS29750	COG0346	lactoylglutathione lyase activity
M621_RS29765	COG1335	isochorismatase
M621_RS29775	COG3011	Protein conserved in bacteria
M621_RS29790	COG3416	Protein conserved in bacteria
M621_RS29800	COG2226	methyltransferase
M621_RS29845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M621_RS29850	COG0667	Aldo Keto reductase
M621_RS29875	COG3123	guanosine phosphorylase activity
M621_RS29890	COG2974	May be involved in recombination
M621_RS29900	COG1129	ABC transporter
M621_RS29905	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS29920	COG0191	fructose-bisphosphate aldolase activity
M621_RS29935	COG1940	carbohydrate kinase activity
M621_RS29955	COG0419	ATPase involved in DNA repair
M621_RS29960	COG0420	3'-5' exonuclease activity
M621_RS29965	COG0745	RESPONSE REGULATOR receiver
M621_RS29970	COG5002	protein histidine kinase activity
M621_RS29980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M621_RS30000	COG0668	transmembrane transport
M621_RS30005	COG0366	Alpha amylase catalytic
M621_RS30015	COG0450	alkyl hydroperoxide reductase
M621_RS30020	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M621_RS30025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M621_RS30030	COG0343	queuine tRNA-ribosyltransferase activity
M621_RS30035	COG1862	Preprotein translocase
M621_RS30045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M621_RS30055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M621_RS30060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M621_RS30060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M621_RS30065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M621_RS30070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M621_RS30075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M621_RS30080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M621_RS30085	COG0667	Aldo Keto reductase
M621_RS30090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M621_RS30095	COG0142	geranyltranstransferase activity
M621_RS30100	COG1722	exodeoxyribonuclease VII activity
M621_RS30105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M621_RS30105	COG0301	tRNA thio-modification
M621_RS30110	COG0693	protein deglycase activity
M621_RS30115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M621_RS30120	COG1666	GTP binding
M621_RS30125	COG2814	Major facilitator Superfamily
M621_RS30130	COG0109	protoheme IX farnesyltransferase activity
M621_RS30135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M621_RS30140	COG1845	cytochrome c oxidase, subunit III
M621_RS30145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M621_RS30150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M621_RS30155	COG2223	nitrite transmembrane transporter activity
M621_RS30160	COG3056	Lipoprotein
M621_RS30165	COG0271	Belongs to the BolA IbaG family
M621_RS30170	COG0544	peptidyl-prolyl cis-trans isomerase activity
M621_RS30180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M621_RS30185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M621_RS30195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M621_RS30200	COG1555	photosystem II stabilization
M621_RS30205	COG0824	Thioesterase
M621_RS30210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M621_RS30215	COG4533	DNA binding
M621_RS30220	COG0561	phosphatase activity
M621_RS30230	COG1522	sequence-specific DNA binding
M621_RS30235	COG1132	(ABC) transporter
M621_RS30240	COG1132	(ABC) transporter
M621_RS30245	COG0347	Belongs to the P(II) protein family
M621_RS30250	COG0004	ammonium transporteR
M621_RS30255	COG1946	Acyl-CoA thioesterase
M621_RS30260	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M621_RS30265	COG3695	enzyme binding
M621_RS30295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M621_RS30315	COG2165	general secretion pathway protein
M621_RS30350	COG3397	chitin binding
M621_RS30380	COG1121	(ABC) transporter
M621_RS30385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M621_RS30390	COG0803	Belongs to the bacterial solute-binding protein 9 family
M621_RS30395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M621_RS30400	COG0254	rRNA binding
M621_RS30405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M621_RS30410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS30415	COG1309	transcriptional regulator
M621_RS30420	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M621_RS30425	COG1196	nuclear chromosome segregation
M621_RS30425	COG3264	Mechanosensitive ion channel
M621_RS30440	COG2832	Protein of unknown function (DUF454)
M621_RS30445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M621_RS30450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M621_RS30460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M621_RS30465	COG0326	Molecular chaperone. Has ATPase activity
M621_RS30470	COG0563	adenylate kinase activity
M621_RS30475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M621_RS30480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M621_RS30495	COG4651	solute:proton antiporter activity
M621_RS30495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M621_RS30500	COG2223	nitrite transmembrane transporter activity
M621_RS30505	COG0737	Belongs to the 5'-nucleotidase family
M621_RS30510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M621_RS30515	COG3735	TraB family
M621_RS30520	COG2217	Heavy metal translocating P-type atpase
M621_RS30525	COG0789	Transcriptional regulator
M621_RS30530	COG1585	Membrane protein implicated in regulation of membrane protease activity
M621_RS30535	COG0330	HflC and HflK could
M621_RS30555	COG3960	tartronate-semialdehyde synthase activity
M621_RS30560	COG3622	Belongs to the hyi family
M621_RS30565	COG2084	Dehydrogenase
M621_RS30570	COG2271	Major facilitator Superfamily
M621_RS30575	COG1929	Belongs to the glycerate kinase type-1 family
M621_RS30580	COG3257	ureidoglycine aminohydrolase activity
M621_RS30590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M621_RS30595	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M621_RS30600	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M621_RS30605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M621_RS30615	COG0549	Belongs to the carbamate kinase family
M621_RS30620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M621_RS30625	COG3118	belongs to the thioredoxin family
M621_RS30630	COG0300	oxidoreductase activity
M621_RS30635	COG2755	lipolytic protein G-D-S-L family
M621_RS30640	COG4181	ATPase activity
M621_RS30645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M621_RS30650	COG2814	Major facilitator Superfamily
M621_RS30660	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M621_RS30665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M621_RS30670	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M621_RS30675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M621_RS30680	COG0215	cysteine-tRNA ligase activity
M621_RS30685	COG2501	S4 domain
M621_RS30690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M621_RS30710	COG0582	viral genome integration into host DNA
M621_RS30775	COG3188	usher protein
M621_RS30780	COG3121	Chaperone
M621_RS30925	COG0667	Aldo Keto reductase
M621_RS30940	COG2199	diguanylate cyclase activity
M621_RS30945	COG1278	Cold shock
M621_RS30955	COG1126	abc transporter atp-binding protein
M621_RS30960	COG0765	amino acid transport
M621_RS30970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS30975	COG1473	amidohydrolase
M621_RS30985	COG2814	Major facilitator Superfamily
M621_RS30995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M621_RS31005	COG3706	GGDEF domain
M621_RS31015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M621_RS31020	COG0321	lipoyl(octanoyl) transferase activity
M621_RS31025	COG2921	Belongs to the UPF0250 family
M621_RS31030	COG1686	Belongs to the peptidase S11 family
M621_RS31035	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M621_RS31040	COG0772	Belongs to the SEDS family
M621_RS31045	COG0768	penicillin binding
M621_RS31050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M621_RS31055	COG0799	negative regulation of ribosome biogenesis
M621_RS31060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M621_RS31065	COG1466	dna polymerase III delta subunit
M621_RS31070	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M621_RS31075	COG0495	leucyl-tRNA aminoacylation
M621_RS31080	COG2888	peptidyl-tyrosine sulfation
M621_RS31090	COG1957	nucleoside hydrolase
M621_RS31095	COG1126	abc transporter atp-binding protein
M621_RS31100	COG0765	amino acid transport
M621_RS31105	COG0765	amino acid transport
M621_RS31115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M621_RS31120	COG4535	Mg2 and Co2 transporter CorC
M621_RS31125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M621_RS31130	COG1702	phosphate starvation-inducible protein PhoH
M621_RS31135	COG2824	Alkylphosphonate utilization operon protein PhnA
M621_RS31140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M621_RS31145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M621_RS31180	COG0367	asparagine synthase
M621_RS31185	COG3469	chitinase activity
M621_RS31190	COG0647	UMP catabolic process
M621_RS31195	COG1846	Transcriptional regulator
M621_RS31195	COG1940	carbohydrate kinase activity
M621_RS31200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M621_RS31205	COG0363	glucosamine-6-phosphate deaminase activity
M621_RS31210	COG1263	PTS System
M621_RS31210	COG2190	(PTS) system
M621_RS31210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS31215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M621_RS31235	COG2814	Major facilitator Superfamily
M621_RS31250	COG0735	belongs to the Fur family
M621_RS31265	COG0596	Alpha beta hydrolase
M621_RS31270	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M621_RS31275	COG0033	Phosphoglucomutase
M621_RS31280	COG1695	Transcriptional regulator
M621_RS31290	COG0745	RESPONSE REGULATOR receiver
M621_RS31295	COG2205	protein histidine kinase activity
M621_RS31300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M621_RS31305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M621_RS31310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M621_RS31325	COG3272	Protein of unknown function (DUF1722)
M621_RS31335	COG5212	phosphodiesterase
M621_RS31340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M621_RS31345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M621_RS31350	COG1984	allophanate hydrolase subunit 2
M621_RS31355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M621_RS31375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M621_RS31390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M621_RS31400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M621_RS31405	COG0567	Dehydrogenase, E1 component
M621_RS31410	COG0508	dehydrogenase complex catalyzes the overall conversion of
M621_RS31415	COG0045	succinate-CoA ligase (ADP-forming) activity
M621_RS31420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M621_RS31425	COG0737	Belongs to the 5'-nucleotidase family
M621_RS31430	COG1271	oxidase subunit
M621_RS31435	COG1294	oxidase, subunit
M621_RS31440	COG3790	cyd operon protein YbgE
M621_RS31445	COG0824	Thioesterase
M621_RS31450	COG0811	peptide transport
M621_RS31455	COG0848	biopolymer transport protein
M621_RS31460	COG3064	Membrane
M621_RS31460	COG3064	Membrane
M621_RS31465	COG0823	Involved in the tonB-independent uptake of proteins
M621_RS31470	COG2885	chlorophyll binding
M621_RS31475	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M621_RS31510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M621_RS31520	COG1230	cation diffusion facilitator family transporter
M621_RS31525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS31525	COG2205	protein histidine kinase activity
M621_RS31530	COG2197	response regulator
M621_RS31535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M621_RS31540	COG0588	phosphoglycerate mutase activity
M621_RS31550	COG2017	converts alpha-aldose to the beta-anomer
M621_RS31555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M621_RS31560	COG1085	galactose-1-phosphate uridylyltransferase
M621_RS31575	COG1119	ATPase activity
M621_RS31580	COG3585	molybdate ion transport
M621_RS31580	COG2005	Transcriptional regulator
M621_RS31590	COG0725	ABC transporter, periplasmic molybdate-binding protein
M621_RS31595	COG4149	molybdate abc transporter
M621_RS31605	COG0561	phosphatase activity
M621_RS31610	COG2706	6-phosphogluconolactonase activity
M621_RS31615	COG1881	PFAM PEBP family protein
M621_RS31630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M621_RS31635	COG0156	8-amino-7-oxononanoate synthase activity
M621_RS31655	COG0556	nucleotide-excision repair
M621_RS31660	COG4628	conserved protein (DUF2132)
M621_RS31665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M621_RS31670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M621_RS31675	COG0521	Mo-molybdopterin cofactor biosynthetic process
M621_RS31680	COG0315	cyclic pyranopterin monophosphate synthase activity
M621_RS31685	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M621_RS31690	COG0314	molybdopterin synthase activity
M621_RS31695	COG0670	Belongs to the BI1 family
M621_RS31700	COG0842	Transport permease protein
M621_RS31705	COG0842	Transport permease protein
M621_RS31710	COG1131	(ABC) transporter
M621_RS31715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS31720	COG1309	transcriptional regulator
M621_RS31725	COG0513	Belongs to the DEAD box helicase family
M621_RS31730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M621_RS31735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M621_RS31760	COG3188	usher protein
M621_RS31765	COG3121	Chaperone
M621_RS31855	COG0583	DNA-binding transcription factor activity
M621_RS31875	COG0583	DNA-binding transcription factor activity
M621_RS31880	COG1280	lysine exporter protein (LysE YggA)
M621_RS31885	COG0586	Pfam SNARE associated Golgi protein
M621_RS31895	COG4977	sequence-specific DNA binding
M621_RS31900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M621_RS31905	COG1686	Belongs to the peptidase S11 family
M621_RS31920	COG2354	Protein conserved in bacteria
M621_RS31930	COG0697	spore germination
M621_RS31945	COG1464	Belongs to the NlpA lipoprotein family
M621_RS31960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M621_RS31975	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS31980	COG0277	FAD linked oxidase domain protein
M621_RS31995	COG1181	Belongs to the D-alanine--D-alanine ligase family
M621_RS32015	COG0436	Aminotransferase
M621_RS32025	COG1472	Belongs to the glycosyl hydrolase 3 family
M621_RS32040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M621_RS32045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M621_RS32050	COG1120	ATPase activity
M621_RS32065	COG1192	Involved in chromosome partitioning
M621_RS32080	COG0583	DNA-binding transcription factor activity
M621_RS32090	COG1070	Carbohydrate kinase
M621_RS32095	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M621_RS32120	COG0366	Alpha amylase catalytic
M621_RS32140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M621_RS32155	COG1309	transcriptional regulator
M621_RS32160	COG1464	Belongs to the NlpA lipoprotein family
M621_RS32165	COG2011	ABC-type metal ion transport system permease component
M621_RS32170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M621_RS32175	COG0456	acetyltransferase
M621_RS32180	COG0583	DNA-binding transcription factor activity
M621_RS32210	COG0583	DNA-binding transcription factor activity
M621_RS32220	COG2271	Major facilitator Superfamily
M621_RS32225	COG1802	Transcriptional regulator
M621_RS32230	COG1063	alcohol dehydrogenase
M621_RS32240	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M621_RS32255	COG4807	Protein conserved in bacteria
M621_RS32285	COG1802	Transcriptional regulator
M621_RS32320	COG3511	phospholipase C
M621_RS32350	COG0583	DNA-binding transcription factor activity
M621_RS32355	COG2897	thiosulfate sulfurtransferase activity
M621_RS32365	COG1683	Conserved Protein
M621_RS32380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M621_RS32390	COG0625	glutathione transferase activity
M621_RS32405	COG1335	isochorismatase
M621_RS32410	COG0583	DNA-binding transcription factor activity
M621_RS32430	COG1732	Glycine betaine
M621_RS32435	COG1174	glycine betaine transport
M621_RS32440	COG1125	glycine betaine transport
M621_RS32445	COG1174	glycine betaine transport
M621_RS32460	COG0583	DNA-binding transcription factor activity
M621_RS32465	COG0697	spore germination
M621_RS32515	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M621_RS32530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M621_RS32535	COG1942	4-Oxalocrotonate Tautomerase
M621_RS32540	COG1199	ATP-dependent helicase activity
M621_RS32545	COG1522	sequence-specific DNA binding
M621_RS32550	COG0697	spore germination
M621_RS32555	COG2814	Major facilitator Superfamily
M621_RS32560	COG0583	DNA-binding transcription factor activity
M621_RS32565	COG1280	lysine exporter protein (LysE YggA)
M621_RS32575	COG0477	Major facilitator Superfamily
M621_RS32585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M621_RS32600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M621_RS32605	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M621_RS32610	COG1126	abc transporter atp-binding protein
M621_RS32615	COG0765	amino acid transport
M621_RS32620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS32625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M621_RS32635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M621_RS32640	COG2731	YhcH YjgK YiaL family protein
M621_RS32650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M621_RS32655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M621_RS32660	COG0583	DNA-binding transcription factor activity
M621_RS32670	COG3622	Belongs to the hyi family
M621_RS32675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M621_RS32680	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
M621_RS32700	COG5002	protein histidine kinase activity
M621_RS32705	COG0745	RESPONSE REGULATOR receiver
M621_RS32710	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
M621_RS32715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M621_RS32725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M621_RS32730	COG1309	transcriptional regulator
M621_RS32735	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS32740	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M621_RS32745	COG0069	glutamate synthase activity
M621_RS32755	COG2200	EAL domain
M621_RS32760	COG3539	Fimbrial protein
M621_RS32780	COG3708	Transcriptional regulator
M621_RS32780	COG2207	Transcriptional regulator
M621_RS32785	COG0579	oxidoreductase
M621_RS32795	COG0702	epimerase
M621_RS32800	COG1309	transcriptional regulator
M621_RS32815	COG0625	glutathione transferase activity
M621_RS32820	COG0640	Transcriptional regulator
M621_RS32845	COG0583	DNA-binding transcription factor activity
M621_RS32860	COG0488	(ABC) transporter
M621_RS32875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M621_RS32880	COG0303	'Molybdopterin
M621_RS32890	COG1446	asparaginase
M621_RS32895	COG4172	Belongs to the ABC transporter superfamily
M621_RS32900	COG0747	negative chemotaxis
M621_RS32905	COG0601	transmembrane transport
M621_RS32910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M621_RS32935	COG0583	DNA-binding transcription factor activity
M621_RS32940	COG0477	Major facilitator Superfamily
M621_RS32945	COG0302	gtp cyclohydrolase
M621_RS32950	COG2311	Membrane
M621_RS32955	COG1609	Transcriptional regulator
M621_RS32975	COG2949	membrane
M621_RS32980	COG0281	malic enzyme
M621_RS32985	COG0295	cytidine deaminase activity
M621_RS32990	COG1346	cytolysis
M621_RS32995	COG1380	Effector of murein hydrolase LrgA
M621_RS33000	COG2814	Major facilitator Superfamily
M621_RS33010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M621_RS33010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M621_RS33015	COG0489	protein tyrosine kinase activity
M621_RS33025	COG0572	uridine kinase
M621_RS33030	COG0717	Belongs to the dCTP deaminase family
M621_RS33035	COG2982	Protein involved in outer membrane biogenesis
M621_RS33040	COG3069	C4-dicarboxylate transmembrane transporter activity
M621_RS33045	COG1253	flavin adenine dinucleotide binding
M621_RS33050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M621_RS33055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M621_RS33110	COG2963	transposase activity
M621_RS33155	COG1088	dTDP-glucose 4,6-dehydratase activity
M621_RS33195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M621_RS33205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M621_RS33220	COG1442	glycosyl transferase family 8
M621_RS33245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M621_RS33255	COG1216	Glycosyl transferase, family 2
M621_RS33255	COG0438	transferase activity, transferring glycosyl groups
M621_RS33265	COG0140	phosphoribosyl-ATP diphosphatase activity
M621_RS33265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M621_RS33270	COG0107	imidazoleglycerol-phosphate synthase activity
M621_RS33275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M621_RS33290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M621_RS33300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M621_RS33305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M621_RS33325	COG0598	Magnesium transport protein CorA
M621_RS33335	COG2133	pyrroloquinoline quinone binding
M621_RS33340	COG0625	glutathione transferase activity
M621_RS33355	COG0626	cystathionine gamma-synthase activity
M621_RS33365	COG1686	Belongs to the peptidase S11 family
M621_RS33370	COG1760	l-serine dehydratase
M621_RS33375	COG0814	amino acid
M621_RS33380	COG1349	DNA-binding transcription factor activity
M621_RS33385	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M621_RS33395	COG0671	phosphoesterase, PA-phosphatase related
M621_RS33410	COG4574	serine-type endopeptidase inhibitor activity
M621_RS33415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M621_RS33430	COG0569	domain protein
M621_RS33430	COG2985	domain, Protein
M621_RS33450	COG0189	ligase activity
M621_RS33460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M621_RS33465	COG3842	ATPase activity
M621_RS33470	COG1176	ABC-type spermidine putrescine transport system, permease component I
M621_RS33475	COG1177	transmembrane transport
M621_RS33485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M621_RS33490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS33495	COG4160	amino acid transport
M621_RS33500	COG4215	(ABC) transporter
M621_RS33505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS33510	COG1126	abc transporter atp-binding protein
M621_RS33520	COG1522	sequence-specific DNA binding
M621_RS33530	COG0393	Putative heavy-metal-binding
M621_RS33540	COG3023	N-Acetylmuramoyl-L-alanine amidase
M621_RS33545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M621_RS33550	COG0702	epimerase
M621_RS33560	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M621_RS33565	COG0028	Belongs to the TPP enzyme family
M621_RS33570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M621_RS33575	COG1151	hydroxylamine reductase activity
M621_RS33580	COG2431	L-lysine efflux transmembrane transporter activity
M621_RS33585	COG3593	DNA synthesis involved in DNA repair
M621_RS33590	COG2990	Protein conserved in bacteria
M621_RS33595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS33605	COG1278	Cold shock
M621_RS33610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M621_RS33615	COG0542	response to heat
M621_RS33620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M621_RS33625	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M621_RS33630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M621_RS33650	COG0492	ferredoxin-NADP+ reductase activity
M621_RS33660	COG3107	peptidoglycan biosynthetic process
M621_RS33660	COG1674	ftsk spoiiie
M621_RS33665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M621_RS33670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M621_RS33675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M621_RS33700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M621_RS33705	COG1882	Formate acetyltransferase
M621_RS33710	COG2116	formate transmembrane transporter activity
M621_RS33715	COG1944	ATP diphosphatase activity
M621_RS33720	COG0252	asparaginase activity
M621_RS33735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M621_RS33740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M621_RS33745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M621_RS33750	COG0539	negative regulation of cytoplasmic translation
M621_RS33755	COG0776	regulation of translation
M621_RS33760	COG0658	competence protein
M621_RS33760	COG2333	competence protein COMEC
M621_RS33770	COG1663	tetraacyldisaccharide 4'-kinase activity
M621_RS33775	COG5383	Protein conserved in bacteria
M621_RS33785	COG1278	Cold shock
M621_RS33790	COG3214	Protein conserved in bacteria
M621_RS33795	COG2835	tetraacyldisaccharide 4'-kinase activity
M621_RS33800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M621_RS33805	COG3173	Aminoglycoside phosphotransferase
M621_RS33810	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M621_RS33815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M621_RS33820	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M621_RS33830	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M621_RS33835	COG2989	Protein conserved in bacteria
M621_RS33840	COG3108	Peptidase M15
M621_RS33845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M621_RS33850	COG1448	Aminotransferase
M621_RS33860	COG0017	Asparaginyl-tRNA synthetase
M621_RS33865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M621_RS33870	COG3706	GGDEF domain
M621_RS33875	COG0308	aminopeptidase N
M621_RS33885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M621_RS33890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS33895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M621_RS33900	COG0431	NADPH-dependent FMN reductase
M621_RS33905	COG0167	dihydroorotate dehydrogenase activity
M621_RS33915	COG3217	Mosc domain protein beta barrel domain protein
M621_RS33915	COG0633	Ferredoxin
M621_RS33920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M621_RS33920	COG0116	Belongs to the methyltransferase superfamily
M621_RS33925	COG0488	(ABC) transporter
M621_RS33930	COG2995	paraquat-inducible protein a
M621_RS33935	COG3008	intermembrane lipid transfer
M621_RS33935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M621_RS33940	COG3009	Protein conserved in bacteria
M621_RS33945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M621_RS33955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M621_RS33960	COG1067	ATP-dependent peptidase activity
M621_RS33965	COG3120	sequence-specific DNA binding
M621_RS33975	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
M621_RS33980	COG3070	regulator of competence-specific genes
M621_RS33985	COG1289	transmembrane transporter activity
M621_RS33990	COG3304	Inner membrane component domain
M621_RS33995	COG0210	DNA helicase
M621_RS34000	COG1803	Methylglyoxal synthase
M621_RS34010	COG1832	CoA-binding protein
M621_RS34015	COG3785	DNA binding
M621_RS34020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M621_RS34025	COG1254	Belongs to the acylphosphatase family
M621_RS34030	COG2920	part of a sulfur-relay system
M621_RS34035	COG0670	Belongs to the BI1 family
M621_RS34060	COG0655	NAD(P)H dehydrogenase (quinone) activity
M621_RS34065	COG1280	lysine exporter protein (LysE YggA)
M621_RS34090	COG2233	PERMEase
M621_RS34095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M621_RS34100	COG2267	carboxylic ester hydrolase activity
M621_RS34105	COG0251	oxidation-reduction process
M621_RS34110	COG1335	isochorismatase
M621_RS34115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS34120	COG1309	transcriptional regulator
M621_RS34125	COG1113	amino acid transport
M621_RS34155	COG2814	Major facilitator Superfamily
M621_RS34160	COG0156	8-amino-7-oxononanoate synthase activity
M621_RS34170	COG1250	3-hydroxyacyl-CoA dehydrogenase
M621_RS34175	COG2197	response regulator
M621_RS34180	COG0589	response to stress
M621_RS34190	COG0531	amino acid
M621_RS34195	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS34200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M621_RS34215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M621_RS34240	COG3136	membrane protein required for alginate biosynthesis
M621_RS34250	COG2197	response regulator
M621_RS34255	COG0322	excinuclease ABC activity
M621_RS34300	COG0477	Major facilitator Superfamily
M621_RS34315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS34320	COG0322	excinuclease ABC activity
M621_RS34350	COG3263	regulation of cellular component size
M621_RS34370	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M621_RS34375	COG2943	transferase activity, transferring hexosyl groups
M621_RS34385	COG5645	(Lipo)protein
M621_RS34400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M621_RS34410	COG0640	Transcriptional regulator
M621_RS34420	COG2391	methyltransferase activity
M621_RS34425	COG0346	lactoylglutathione lyase activity
M621_RS34435	COG2814	Major facilitator Superfamily
M621_RS34445	COG1560	Kdo2-lipid A biosynthetic process
M621_RS34455	COG1902	pentaerythritol trinitrate reductase activity
M621_RS34460	COG1054	Belongs to the UPF0176 family
M621_RS34465	COG2353	YceI-like domain
M621_RS34470	COG3038	cytochrome b561
M621_RS34475	COG0628	permease
M621_RS34505	COG0418	dihydroorotase activity
M621_RS34510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M621_RS34515	COG1530	ribonuclease E activity
M621_RS34520	COG0564	pseudouridine synthase activity
M621_RS34530	COG1399	metal-binding, possibly nucleic acid-binding protein
M621_RS34535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M621_RS34540	COG0416	fatty acid biosynthetic process
M621_RS34545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M621_RS34550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M621_RS34560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M621_RS34565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M621_RS34575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M621_RS34580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M621_RS34585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M621_RS34590	COG0470	DNA polymerase III
M621_RS34595	COG0084	hydrolase, TatD family'
M621_RS34600	COG1263	PTS System
M621_RS34600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS34605	COG1321	iron dependent repressor
M621_RS34610	COG1914	H( )-stimulated, divalent metal cation uptake system
M621_RS34620	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS34625	COG1733	regulation of RNA biosynthetic process
M621_RS34630	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M621_RS34635	COG0537	adenosine 5'-monophosphoramidase activity
M621_RS34640	COG5633	Lipoprotein
M621_RS34645	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
M621_RS34660	COG3150	esterase
M621_RS34665	COG1252	NADH dehydrogenase
M621_RS34670	COG3134	Outer membrane lipoprotein
M621_RS34685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS34690	COG2207	Transcriptional regulator
M621_RS34690	COG3708	Transcriptional regulator
M621_RS34710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M621_RS34715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M621_RS34720	COG3381	protein complex oligomerization
M621_RS34725	COG2979	Protein of unknown function (DUF533)
M621_RS34730	COG1770	oligopeptidase
M621_RS34735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M621_RS34740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M621_RS34760	COG1528	Iron-storage protein
M621_RS34765	COG2372	response to copper ion
M621_RS34770	COG1276	copper resistance
M621_RS34785	COG0745	RESPONSE REGULATOR receiver
M621_RS34795	COG4771	TonB-dependent receptor
M621_RS34820	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M621_RS34830	COG3655	Transcriptional regulator
M621_RS34860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M621_RS34865	COG4565	transcriptional regulatory protein
M621_RS34870	COG3290	protein histidine kinase activity
M621_RS34885	COG1129	ABC transporter
M621_RS34890	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS34900	COG1464	Belongs to the NlpA lipoprotein family
M621_RS34910	COG0589	response to stress
M621_RS34915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M621_RS34920	COG2313	pseudouridylate synthase activity
M621_RS34925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M621_RS34945	COG0740	serine-type endopeptidase activity
M621_RS34965	COG0012	GTP binding
M621_RS34970	COG0659	secondary active sulfate transmembrane transporter activity
M621_RS34975	COG0193	aminoacyl-tRNA hydrolase activity
M621_RS34985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M621_RS34990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M621_RS34995	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M621_RS35005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M621_RS35010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M621_RS35015	COG2890	protein-(glutamine-N5) methyltransferase activity
M621_RS35030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M621_RS35035	COG0659	secondary active sulfate transmembrane transporter activity
M621_RS35040	COG4702	Belongs to the UPF0303 family
M621_RS35045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M621_RS35060	COG4591	ABC-type transport system involved in lipoprotein release permease component
M621_RS35070	COG4591	ABC-type transport system involved in lipoprotein release permease component
M621_RS35075	COG1940	carbohydrate kinase activity
M621_RS35090	COG1486	melibiose metabolic process
M621_RS35095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS35095	COG1263	PTS System
M621_RS35100	COG2195	Cleaves the N-terminal amino acid of tripeptides
M621_RS35105	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M621_RS35110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M621_RS35120	COG0583	DNA-binding transcription factor activity
M621_RS35125	COG2850	peptidyl-arginine hydroxylation
M621_RS35135	COG0745	RESPONSE REGULATOR receiver
M621_RS35155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M621_RS35160	COG2915	High frequency lysogenization protein hflD homolog
M621_RS35165	COG0482	sulfurtransferase activity
M621_RS35175	COG1187	pseudouridine synthase activity
M621_RS35180	COG0538	isocitrate dehydrogenase activity
M621_RS35185	COG0582	viral genome integration into host DNA
M621_RS35200	COG0463	Glycosyl transferase, family 2
M621_RS35210	COG3064	Membrane
M621_RS35225	COG0628	permease
M621_RS35245	COG0673	inositol 2-dehydrogenase activity
M621_RS35275	COG1278	Cold shock
M621_RS35285	COG1335	isochorismatase
M621_RS35290	COG0589	response to stress
M621_RS35295	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS35300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M621_RS35305	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS35310	COG1917	Cupin 2, conserved barrel domain protein
M621_RS35310	COG1396	sequence-specific DNA binding
M621_RS35315	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M621_RS35320	COG0174	glutamine synthetase
M621_RS35325	COG0531	amino acid
M621_RS35355	COG1605	Chorismate mutase
M621_RS35375	COG1228	amidohydrolase
M621_RS35385	COG0402	S-adenosylhomocysteine deaminase activity
M621_RS35395	COG2358	TRAP transporter, solute receptor (TAXI family
M621_RS35400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M621_RS35405	COG1116	anion transmembrane transporter activity
M621_RS35410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M621_RS35420	COG0371	Dehydrogenase
M621_RS35435	COG2211	Major facilitator Superfamily
M621_RS35440	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS35455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M621_RS35465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M621_RS35475	COG0477	Major facilitator Superfamily
M621_RS35495	COG0402	S-adenosylhomocysteine deaminase activity
M621_RS35500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M621_RS35505	COG3493	citrate carrier protein
M621_RS35560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M621_RS35560	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M621_RS35565	COG3008	intermembrane lipid transfer
M621_RS35570	COG2995	paraquat-inducible protein a
M621_RS35575	COG1956	GAF domain-containing protein
M621_RS35580	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M621_RS35585	COG0793	Belongs to the peptidase S41A family
M621_RS35595	COG0501	Belongs to the peptidase M48B family
M621_RS35600	COG2814	Major facilitator Superfamily
M621_RS35610	COG1823	symporter activity
M621_RS35615	COG1988	membrane-bound metal-dependent
M621_RS35620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M621_RS35635	COG3001	Fructosamine kinase
M621_RS35645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M621_RS35650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M621_RS35655	COG1121	(ABC) transporter
M621_RS35660	COG0803	Belongs to the bacterial solute-binding protein 9 family
M621_RS35690	COG0814	amino acid
M621_RS35720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M621_RS35730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M621_RS35735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M621_RS35740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M621_RS35750	COG0776	regulation of translation
M621_RS35765	COG4139	cobalamin transport
M621_RS35770	COG0386	Belongs to the glutathione peroxidase family
M621_RS35775	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M621_RS35780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M621_RS35785	COG1215	transferase activity, transferring glycosyl groups
M621_RS35790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M621_RS35790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M621_RS35795	COG0726	polysaccharide deacetylase
M621_RS35800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M621_RS35805	COG2076	Multidrug Resistance protein
M621_RS35810	COG2076	Multidrug Resistance protein
M621_RS35815	COG0791	NLP P60 protein
M621_RS35820	COG0095	Lipoate-protein ligase
M621_RS35840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M621_RS35845	COG4558	Periplasmic binding protein
M621_RS35850	COG3720	iron ion transport
M621_RS35865	COG0386	Belongs to the glutathione peroxidase family
M621_RS35870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M621_RS35875	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M621_RS35880	COG0574	Belongs to the PEP-utilizing enzyme family
M621_RS35880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M621_RS35885	COG0628	permease
M621_RS35890	COG0277	FAD linked oxidase domain protein
M621_RS35890	COG0247	lactate metabolic process
M621_RS35895	COG2050	protein possibly involved in aromatic compounds catabolism
M621_RS35905	COG0316	Belongs to the HesB IscA family
M621_RS35910	COG0719	Fe-S assembly protein
M621_RS35915	COG0396	ATPase activity
M621_RS35920	COG0719	Fe-S assembly protein
M621_RS35925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M621_RS35930	COG2166	iron-sulfur cluster assembly
M621_RS35935	COG1376	ErfK ybiS ycfS ynhG family protein
M621_RS35935	COG1388	LysM domain
M621_RS35970	COG0534	Mate efflux family protein
M621_RS35975	COG0307	riboflavin synthase, alpha
M621_RS35985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M621_RS35990	COG2814	Major facilitator Superfamily
M621_RS35995	COG0583	DNA-binding transcription factor activity
M621_RS36000	COG1609	Transcriptional regulator
M621_RS36005	COG0791	NLP P60 protein
M621_RS36010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M621_RS36020	COG0346	lactoylglutathione lyase activity
M621_RS36025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M621_RS36030	COG1902	pentaerythritol trinitrate reductase activity
M621_RS36035	COG1309	transcriptional regulator
M621_RS36040	COG2194	sulfuric ester hydrolase activity
M621_RS36050	COG0583	DNA-binding transcription factor activity
M621_RS36055	COG3313	Fe-S protein
M621_RS36060	COG4989	oxidoreductase activity
M621_RS36065	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M621_RS36075	COG1289	transmembrane transporter activity
M621_RS36080	COG1566	PFAM secretion protein HlyD family protein
M621_RS36085	COG1846	Transcriptional regulator
M621_RS36090	COG3133	Outer membrane lipoprotein
M621_RS36095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M621_RS36100	COG3895	Periplasmic Protein
M621_RS36105	COG0259	pyridoxamine-phosphate oxidase activity
M621_RS36110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M621_RS36120	COG0625	glutathione transferase activity
M621_RS36135	COG1418	mRNA catabolic process
M621_RS36180	COG3135	benzoate transporter
M621_RS36185	COG1396	sequence-specific DNA binding
M621_RS36190	COG1505	serine-type exopeptidase activity
M621_RS36195	COG3104	oligopeptide transport
M621_RS36205	COG2211	Major facilitator Superfamily
M621_RS36210	COG3708	Transcriptional regulator
M621_RS36210	COG2207	Transcriptional regulator
M621_RS36220	COG2211	Major facilitator Superfamily
M621_RS36225	COG3507	Belongs to the glycosyl hydrolase 43 family
M621_RS36230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M621_RS36240	COG4659	FMN binding
M621_RS36250	COG3708	Transcriptional regulator
M621_RS36250	COG2207	Transcriptional regulator
M621_RS36255	COG4656	Part of a membrane complex involved in electron transport
M621_RS36260	COG2878	Part of a membrane complex involved in electron transport
M621_RS36265	COG4657	Part of a membrane complex involved in electron transport
M621_RS36275	COG2160	L-arabinose isomerase activity
M621_RS36280	COG1069	ribulokinase activity
M621_RS36285	COG1879	ABC-type sugar transport system periplasmic component
M621_RS36290	COG1129	ABC transporter
M621_RS36295	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS36310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M621_RS36315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M621_RS36320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M621_RS36325	COG0673	inositol 2-dehydrogenase activity
M621_RS36330	COG0385	Bile acid
M621_RS36335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M621_RS36370	COG0205	6-phosphofructokinase activity
M621_RS36375	COG1349	DNA-binding transcription factor activity
M621_RS36380	COG0494	nUDIX hydrolase
M621_RS36390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M621_RS36395	COG1263	PTS System
M621_RS36395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS36400	COG1609	Transcriptional regulator
M621_RS36425	COG5339	Protein conserved in bacteria
M621_RS36440	COG0114	fumarate hydratase activity
M621_RS36450	COG0583	DNA-binding transcription factor activity
M621_RS36455	COG2378	regulation of single-species biofilm formation
M621_RS36470	COG2814	Major facilitator Superfamily
M621_RS36475	COG0583	DNA-binding transcription factor activity
M621_RS36480	COG1940	carbohydrate kinase activity
M621_RS36485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M621_RS36495	COG0477	Major facilitator Superfamily
M621_RS36510	COG1742	UPF0060 membrane protein
M621_RS36515	COG4221	oxidoreductase activity
M621_RS36525	COG0667	Aldo Keto reductase
M621_RS36530	COG0477	Major facilitator Superfamily
M621_RS36540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M621_RS36555	COG2182	Extracellular solute-binding protein
M621_RS36560	COG1940	carbohydrate kinase activity
M621_RS36565	COG0402	S-adenosylhomocysteine deaminase activity
M621_RS36575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M621_RS36595	COG2188	Transcriptional regulator
M621_RS36600	COG0366	Alpha amylase catalytic
M621_RS36610	COG0339	signal peptide processing
M621_RS36620	COG2271	Major facilitator Superfamily
M621_RS36625	COG1335	isochorismatase
M621_RS36630	COG3473	Maleate cis-trans isomerase
M621_RS36635	COG0596	Alpha beta hydrolase
M621_RS36640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M621_RS36645	COG2309	aminopeptidase activity
M621_RS36650	COG1846	Transcriptional regulator
M621_RS36655	COG2080	2 iron, 2 sulfur cluster binding
M621_RS36660	COG2010	Cytochrome c
M621_RS36660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M621_RS36675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M621_RS36695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS36695	COG2190	(PTS) system
M621_RS36695	COG1263	PTS System
M621_RS36700	COG2723	6-phospho-beta-galactosidase activity
M621_RS36705	COG3711	transcriptional antiterminator
M621_RS36730	COG3609	addiction module antidote protein, CC2985 family
M621_RS36740	COG0384	phenazine biosynthesis protein PhzF
M621_RS36770	COG2814	Major facilitator Superfamily
M621_RS36775	COG1215	transferase activity, transferring glycosyl groups
M621_RS36795	COG3153	acetyltransferase
M621_RS36805	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M621_RS36810	COG0747	negative chemotaxis
M621_RS36815	COG0601	transmembrane transport
M621_RS36820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M621_RS36825	COG0444	Belongs to the ABC transporter superfamily
M621_RS36830	COG4608	Belongs to the ABC transporter superfamily
M621_RS36845	COG0583	DNA-binding transcription factor activity
M621_RS36860	COG0768	penicillin binding
M621_RS36885	COG1126	abc transporter atp-binding protein
M621_RS36890	COG0765	amino acid transport
M621_RS36900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS36905	COG2079	MmgE PrpD family protein
M621_RS36920	COG2814	Major facilitator Superfamily
M621_RS36930	COG2814	Major facilitator Superfamily
M621_RS36935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M621_RS36955	COG0371	Dehydrogenase
M621_RS36965	COG1309	transcriptional regulator
M621_RS37025	COG2315	Protein conserved in bacteria
M621_RS37035	COG2182	Extracellular solute-binding protein
M621_RS37040	COG1175	transmembrane transport
M621_RS37045	COG3833	ABC-type maltose transport systems, permease component
M621_RS37055	COG1874	Beta-galactosidase
M621_RS37075	COG1309	transcriptional regulator
M621_RS37095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M621_RS37100	COG2862	Uncharacterized protein family, UPF0114
M621_RS37120	COG4558	Periplasmic binding protein
M621_RS37135	COG0673	inositol 2-dehydrogenase activity
M621_RS37140	COG3622	Belongs to the hyi family
M621_RS37150	COG2814	Major facilitator Superfamily
M621_RS37155	COG0583	DNA-binding transcription factor activity
M621_RS37180	COG1522	sequence-specific DNA binding
M621_RS37200	COG1902	pentaerythritol trinitrate reductase activity
M621_RS37235	COG3284	Transcriptional regulator
M621_RS37250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS37260	COG4993	Dehydrogenase
M621_RS37265	COG2207	Transcriptional regulator
M621_RS37280	COG3604	Transcriptional regulator
M621_RS37285	COG1773	rubredoxin
M621_RS37285	COG0426	domain, Protein
M621_RS37290	COG0446	pyridine nucleotide-disulphide oxidoreductase
M621_RS37310	COG0076	glutamate decarboxylase activity
M621_RS37315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M621_RS37345	COG3713	MltA-interacting MipA family protein
M621_RS37350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M621_RS37360	COG1609	Transcriptional regulator
M621_RS37370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M621_RS37370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M621_RS37375	COG2723	6-phospho-beta-galactosidase activity
M621_RS37380	COG1447	Phosphotransferase system cellobiose-specific component IIA
M621_RS37385	COG4580	involved in the transport of maltose and maltodextrins
M621_RS37400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M621_RS37415	COG2211	Major facilitator Superfamily
M621_RS37420	COG0508	dehydrogenase complex catalyzes the overall conversion of
M621_RS37425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M621_RS37435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M621_RS37445	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS37455	COG4221	oxidoreductase activity
M621_RS37460	COG1733	regulation of RNA biosynthetic process
M621_RS37465	COG0702	epimerase
M621_RS37480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M621_RS37495	COG0673	inositol 2-dehydrogenase activity
M621_RS37500	COG1082	Xylose isomerase domain protein TIM barrel
M621_RS37505	COG0583	DNA-binding transcription factor activity
M621_RS37510	COG2249	NAD(P)H dehydrogenase (quinone) activity
M621_RS37515	COG2249	NAD(P)H dehydrogenase (quinone) activity
M621_RS37520	COG1733	regulation of RNA biosynthetic process
M621_RS37555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M621_RS37570	COG0693	protein deglycase activity
M621_RS37585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M621_RS37610	COG3135	benzoate transporter
M621_RS37615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M621_RS37620	COG1396	sequence-specific DNA binding
M621_RS37630	COG0583	DNA-binding transcription factor activity
M621_RS37655	COG1464	Belongs to the NlpA lipoprotein family
M621_RS37660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M621_RS37665	COG2011	ABC-type metal ion transport system permease component
M621_RS37670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M621_RS37680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M621_RS37685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M621_RS37690	COG1045	serine acetyltransferase
M621_RS37700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M621_RS37705	COG2271	Major facilitator Superfamily
M621_RS37710	COG1737	Transcriptional regulator
M621_RS37715	COG2723	6-phospho-beta-galactosidase activity
M621_RS37720	COG3485	protocatechuate 3,4-dioxygenase
M621_RS37725	COG3485	protocatechuate 3,4-dioxygenase
M621_RS37730	COG0583	DNA-binding transcription factor activity
M621_RS37735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M621_RS37750	COG2814	Major facilitator Superfamily
M621_RS37765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M621_RS37770	COG1082	Xylose isomerase domain protein TIM barrel
M621_RS37770	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M621_RS37800	COG1414	Transcriptional regulator
M621_RS37805	COG3048	D-serine ammonia-lyase activity
M621_RS37820	COG5507	3-demethylubiquinone-9 3-methyltransferase
M621_RS37825	COG2199	diguanylate cyclase activity
M621_RS37830	COG2011	ABC-type metal ion transport system permease component
M621_RS37850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M621_RS37860	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS37865	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS37870	COG1129	ABC transporter
M621_RS37880	COG0366	Alpha amylase catalytic
M621_RS37885	COG3842	ATPase activity
M621_RS37905	COG1653	transport
M621_RS37910	COG0583	DNA-binding transcription factor activity
M621_RS37915	COG2190	(PTS) system
M621_RS37915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS37915	COG1263	PTS System
M621_RS37920	COG3264	Mechanosensitive ion channel
M621_RS37920	COG1196	nuclear chromosome segregation
M621_RS37925	COG0488	(ABC) transporter
M621_RS37935	COG1917	Cupin 2, conserved barrel domain protein
M621_RS37935	COG2207	Transcriptional regulator
M621_RS37970	COG2239	Acts as a magnesium transporter
M621_RS37985	COG0583	DNA-binding transcription factor activity
M621_RS38005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M621_RS38010	COG0697	spore germination
M621_RS38040	COG0657	acetylesterase activity
M621_RS38065	COG3158	transport of potassium into the cell
M621_RS38125	COG0306	phosphate transporter
M621_RS38140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS38165	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M621_RS38185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M621_RS38195	COG0589	response to stress
M621_RS38200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M621_RS38205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M621_RS38215	COG0531	amino acid
M621_RS38230	COG0745	RESPONSE REGULATOR receiver
M621_RS38235	COG2205	protein histidine kinase activity
M621_RS38240	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M621_RS38255	COG3591	Belongs to the peptidase S1B family
M621_RS38260	COG1643	Atp-dependent helicase
M621_RS38265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M621_RS38270	COG3784	Protein of unknown function (DUF1318)
M621_RS38280	COG2911	Protein conserved in bacteria
M621_RS38285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M621_RS38290	COG3187	Heat shock protein
M621_RS38295	COG3042	response to heat
M621_RS38305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M621_RS38305	COG0674	pyruvate-flavodoxin oxidoreductase activity
M621_RS38305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M621_RS38305	COG1013	pyruvate-flavodoxin oxidoreductase activity
M621_RS38325	COG0037	tRNA processing
M621_RS38345	COG4166	transmembrane transport
M621_RS38355	COG2866	Carboxypeptidase
M621_RS38360	COG4948	Mandelate Racemase Muconate Lactonizing
M621_RS38365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M621_RS38375	COG3768	UPF0283 membrane protein
M621_RS38380	COG3106	COG3106 Predicted ATPase
M621_RS38395	COG1983	PspC domain protein
M621_RS38405	COG1842	Phage shock protein A
M621_RS38410	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M621_RS38425	COG1469	GTP cyclohydrolase I activity
M621_RS38435	COG4168	peptide transport system, permease
M621_RS38440	COG4171	peptide transport system, permease
M621_RS38445	COG4172	Belongs to the ABC transporter superfamily
M621_RS38455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M621_RS38455	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M621_RS38470	COG0243	molybdopterin cofactor binding
M621_RS38475	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M621_RS38480	COG1966	Carbon starvation protein
M621_RS38485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M621_RS38490	COG1349	DNA-binding transcription factor activity
M621_RS38495	COG0235	Class ii aldolase
M621_RS38505	COG0023	Translation Initiation Factor
M621_RS38525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M621_RS38530	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M621_RS38535	COG0671	phosphoesterase, PA-phosphatase related
M621_RS38545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M621_RS38555	COG0583	DNA-binding transcription factor activity
M621_RS38570	COG0616	signal peptide processing
M621_RS38575	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS38580	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M621_RS38585	COG1187	pseudouridine synthase activity
M621_RS38600	COG0009	L-threonylcarbamoyladenylate synthase
M621_RS38605	COG0613	PHP domain protein
M621_RS38620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M621_RS38630	COG0133	tryptophan synthase activity
M621_RS38635	COG0159	tryptophan synthase activity
M621_RS38645	COG3047	cAMP biosynthetic process
M621_RS38650	COG0727	PFAM Uncharacterised protein family (UPF0153)
M621_RS38665	COG2917	probably involved in intracellular septation
M621_RS38670	COG1607	acyl-coa hydrolase
M621_RS38680	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M621_RS38685	COG2350	Protein conserved in bacteria
M621_RS38690	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M621_RS38720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M621_RS38725	COG3099	Belongs to the UPF0263 family
M621_RS38735	COG0444	Belongs to the ABC transporter superfamily
M621_RS38740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M621_RS38755	COG4166	transmembrane transport
M621_RS38760	COG2095	MarC family integral membrane protein
M621_RS38765	COG1454	alcohol dehydrogenase
M621_RS38765	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS38790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M621_RS38795	COG0745	RESPONSE REGULATOR receiver
M621_RS38800	COG1752	Esterase of the alpha-beta hydrolase superfamily
M621_RS38805	COG3012	SEC-C Motif Domain Protein
M621_RS38810	COG0788	formyltetrahydrofolate deformylase activity
M621_RS38830	COG0708	Exodeoxyribonuclease III
M621_RS38835	COG0494	nUDIX hydrolase
M621_RS38845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M621_RS38850	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
M621_RS38860	COG0778	Nitroreductase
M621_RS38865	COG0616	signal peptide processing
M621_RS38870	COG0252	asparaginase activity
M621_RS38875	COG1335	isochorismatase
M621_RS38885	COG3139	Protein of unknown function (DUF1315)
M621_RS38890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M621_RS38895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M621_RS38905	COG3713	MltA-interacting MipA family protein
M621_RS38910	COG2766	serine protein kinase
M621_RS38915	COG2718	Belongs to the UPF0229 family
M621_RS38950	COG4774	siderophore transport
M621_RS38960	COG0444	Belongs to the ABC transporter superfamily
M621_RS38975	COG0601	transmembrane transport
M621_RS38990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M621_RS38995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M621_RS39000	COG2719	SpoVR family
M621_RS39005	COG2186	Transcriptional regulator
M621_RS39010	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M621_RS39015	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M621_RS39020	COG2983	Belongs to the UPF0260 family
M621_RS39030	COG0179	Fumarylacetoacetate (FAA) hydrolase
M621_RS39035	COG2951	lytic endotransglycosylase activity
M621_RS39040	COG3100	YcgL domain-containing protein
M621_RS39045	COG0850	regulation of cytokinetic process
M621_RS39050	COG2894	cell division
M621_RS39055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M621_RS39060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M621_RS39065	COG0318	PFAM AMP-dependent synthetase and ligase
M621_RS39070	COG3065	identical protein binding
M621_RS39080	COG1199	ATP-dependent helicase activity
M621_RS39085	COG0251	oxidation-reduction process
M621_RS39090	COG2076	Multidrug Resistance protein
M621_RS39095	COG2076	Multidrug Resistance protein
M621_RS39100	COG0800	Aldolase
M621_RS39105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M621_RS39115	COG1737	Transcriptional regulator
M621_RS39120	COG0469	pyruvate kinase activity
M621_RS39130	COG1560	Kdo2-lipid A biosynthetic process
M621_RS39135	COG0739	heme binding
M621_RS39140	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M621_RS39145	COG1121	(ABC) transporter
M621_RS39150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M621_RS39155	COG2255	four-way junction helicase activity
M621_RS39160	COG0632	four-way junction helicase activity
M621_RS39165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M621_RS39170	COG0217	transcriptional regulatory protein
M621_RS39175	COG0494	nUDIX hydrolase
M621_RS39180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M621_RS39190	COG1335	isochorismatase
M621_RS39195	COG1801	Protein of unknown function DUF72
M621_RS39200	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M621_RS39205	COG2226	methyltransferase
M621_RS39210	COG0500	methyltransferase
M621_RS39215	COG0545	Peptidyl-prolyl cis-trans isomerase
M621_RS39225	COG3142	Participates in the control of copper homeostasis
M621_RS39230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M621_RS39235	COG3102	Protein conserved in bacteria
M621_RS39240	COG0018	arginyl-trna synthetase
M621_RS39255	COG3132	Protein of unknown function, DUF480
M621_RS39260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M621_RS39265	COG0477	Major facilitator Superfamily
M621_RS39275	COG2999	glutathione oxidoreductase activity
M621_RS39295	COG3097	Belongs to the UPF0267 family
M621_RS39300	COG3141	response to X-ray
M621_RS39305	COG0513	Belongs to the DEAD box helicase family
M621_RS39310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M621_RS39315	COG3140	Belongs to the UPF0181 family
M621_RS39320	COG1216	Glycosyl transferase, family 2
M621_RS39330	COG0494	nUDIX hydrolase
M621_RS39335	COG1760	l-serine dehydratase
M621_RS39340	COG2200	EAL domain
M621_RS39345	COG1253	flavin adenine dinucleotide binding
M621_RS39350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M621_RS39350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS39355	COG3715	PTS system
M621_RS39360	COG3716	PTS system mannose fructose sorbose family IID component
M621_RS39365	COG4811	Protein of unknown function (DUF986)
M621_RS39370	COG1971	Probably functions as a manganese efflux pump
M621_RS39380	COG0640	Transcriptional regulator
M621_RS39385	COG2226	methyltransferase
M621_RS39410	COG1113	amino acid transport
M621_RS39455	COG2207	Transcriptional regulator
M621_RS39470	COG1652	LysM domain
M621_RS39490	COG2988	succinylglutamate desuccinylase activity
M621_RS39495	COG3724	N-succinylarginine dihydrolase activity
M621_RS39500	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS39505	COG3138	arginine N-succinyltransferase
M621_RS39510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M621_RS39520	COG4608	Belongs to the ABC transporter superfamily
M621_RS39525	COG0444	Belongs to the ABC transporter superfamily
M621_RS39535	COG0601	transmembrane transport
M621_RS39545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M621_RS39550	COG1271	oxidase subunit
M621_RS39555	COG1294	oxidase, subunit
M621_RS39600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M621_RS39605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M621_RS39610	COG2181	nitrate reductase activity
M621_RS39615	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M621_RS39620	COG1140	nitrate reductase beta subunit
M621_RS39625	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M621_RS39635	COG0463	Glycosyl transferase, family 2
M621_RS39635	COG1216	Glycosyl transferase, family 2
M621_RS39640	COG1216	Glycosyl transferase, family 2
M621_RS39650	COG1215	transferase activity, transferring glycosyl groups
M621_RS39660	COG0463	Glycosyl transferase, family 2
M621_RS39685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M621_RS39690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M621_RS39695	COG3710	Transcriptional regulator
M621_RS39700	COG2223	nitrite transmembrane transporter activity
M621_RS39710	COG3850	Histidine kinase
M621_RS39715	COG2197	response regulator
M621_RS39720	COG4932	domain protein
M621_RS39735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M621_RS39735	COG1648	precorrin-2 dehydrogenase activity
M621_RS39740	COG0243	molybdopterin cofactor binding
M621_RS39745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M621_RS39745	COG2146	nitrite reductase [NAD(P)H] activity
M621_RS39750	COG1116	anion transmembrane transporter activity
M621_RS39760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M621_RS39765	COG3707	response regulator
M621_RS39775	COG4608	Belongs to the ABC transporter superfamily
M621_RS39780	COG0444	Belongs to the ABC transporter superfamily
M621_RS39785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M621_RS39790	COG0601	transmembrane transport
M621_RS39795	COG4166	transmembrane transport
M621_RS39800	COG0583	DNA-binding transcription factor activity
M621_RS39805	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M621_RS39810	COG4572	Cation transport regulator
M621_RS39815	COG2375	cellular response to nickel ion
M621_RS39820	COG0387	Pfam Sodium calcium exchanger
M621_RS39830	COG1702	phosphate starvation-inducible protein PhoH
M621_RS39835	COG4772	TonB-dependent receptor
M621_RS39850	COG0672	)-iron permease
M621_RS39865	COG0506	proline dehydrogenase activity
M621_RS39865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M621_RS39865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M621_RS39875	COG1126	abc transporter atp-binding protein
M621_RS39880	COG0765	amino acid transport
M621_RS39885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS39890	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M621_RS39900	COG1191	sigma factor activity
M621_RS39935	COG1677	Flagellar hook-basal body complex protein FliE
M621_RS39945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M621_RS39950	COG1317	bacterial-type flagellum organization
M621_RS39955	COG1157	protein secretion by the type III secretion system
M621_RS39960	COG2882	bacterial-type flagellum organization
M621_RS39965	COG3144	bacterial-type flagellum assembly
M621_RS39970	COG1580	Controls the rotational direction of flagella during chemotaxis
M621_RS40020	COG1256	bacterial-type flagellum assembly
M621_RS40040	COG4786	Flagellar basal body rod
M621_RS40050	COG1749	Flagellar hook protein flgE
M621_RS40055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M621_RS40060	COG1558	bacterial-type flagellum-dependent cell motility
M621_RS40065	COG1815	bacterial-type flagellum-dependent cell motility
M621_RS40075	COG2747	anti-sigma28 factor FlgM
M621_RS40080	COG3418	PFAM FlgN family protein
M621_RS40090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M621_RS40100	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M621_RS40105	COG0745	RESPONSE REGULATOR receiver
M621_RS40115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M621_RS40120	COG0840	transmembrane signaling receptor activity
M621_RS40125	COG0840	transmembrane signaling receptor activity
M621_RS40135	COG0835	chemotaxis
M621_RS40140	COG0643	Histidine kinase
M621_RS40140	COG2198	Histidine kinase
M621_RS40185	COG2130	NADP-dependent
M621_RS40190	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M621_RS40195	COG3483	tryptophan 2,3-dioxygenase activity
M621_RS40205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M621_RS40260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M621_RS40275	COG2211	Major facilitator Superfamily
M621_RS40280	COG1609	Transcriptional regulator
M621_RS40285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M621_RS40335	COG4191	Histidine kinase
M621_RS40340	COG1414	Transcriptional regulator
M621_RS40350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M621_RS40355	COG0183	Belongs to the thiolase family
M621_RS40360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M621_RS40365	COG1393	Belongs to the ArsC family
M621_RS40370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M621_RS40380	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M621_RS40420	COG1285	pathogenesis
M621_RS40430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M621_RS40435	COG0583	DNA-binding transcription factor activity
M621_RS40470	COG0604	alcohol dehydrogenase
M621_RS40470	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS40470	COG3321	synthase
M621_RS40490	COG3753	Protein conserved in bacteria
M621_RS40495	COG2261	transglycosylase associated protein
M621_RS40505	COG0583	DNA-binding transcription factor activity
M621_RS40510	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS40515	COG2764	glyoxalase bleomycin resistance protein dioxygenase
M621_RS40525	COG2203	Gaf domain
M621_RS40525	COG3706	GGDEF domain
M621_RS40525	COG4251	negative regulation of phosphorylation
M621_RS40525	COG5001	Diguanylate cyclase
M621_RS40530	COG2030	dehydratase
M621_RS40530	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS40535	COG3396	Phenylacetate-CoA oxygenase
M621_RS40540	COG3460	Phenylacetate-CoA oxygenase
M621_RS40545	COG3396	Phenylacetate-CoA oxygenase
M621_RS40550	COG2151	metal-sulfur cluster biosynthetic enzyme
M621_RS40555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M621_RS40560	COG1024	Enoyl-CoA hydratase
M621_RS40565	COG1024	Enoyl-CoA hydratase
M621_RS40570	COG1250	3-hydroxyacyl-CoA dehydrogenase
M621_RS40575	COG2050	protein possibly involved in aromatic compounds catabolism
M621_RS40580	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M621_RS40585	COG3327	negative regulation of DNA-templated transcription, initiation
M621_RS40590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M621_RS40595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M621_RS40610	COG0697	spore germination
M621_RS40615	COG1113	amino acid transport
M621_RS40635	COG0583	DNA-binding transcription factor activity
M621_RS40640	COG0625	glutathione transferase activity
M621_RS40675	COG4993	Dehydrogenase
M621_RS40685	COG2223	nitrite transmembrane transporter activity
M621_RS40690	COG1486	melibiose metabolic process
M621_RS40700	COG0534	Mate efflux family protein
M621_RS40720	COG0673	inositol 2-dehydrogenase activity
M621_RS40750	COG3228	Belongs to the MtfA family
M621_RS40760	COG0604	alcohol dehydrogenase
M621_RS40775	COG1902	pentaerythritol trinitrate reductase activity
M621_RS40785	COG3706	GGDEF domain
M621_RS40815	COG1063	alcohol dehydrogenase
M621_RS40820	COG0095	Lipoate-protein ligase
M621_RS40825	COG3284	Transcriptional regulator
M621_RS40830	COG1609	Transcriptional regulator
M621_RS40835	COG1840	ABC-type Fe3 transport system, periplasmic component
M621_RS40845	COG3842	ATPase activity
M621_RS40855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M621_RS40860	COG4977	sequence-specific DNA binding
M621_RS40870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS40875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M621_RS40880	COG1116	anion transmembrane transporter activity
M621_RS40885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M621_RS40890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M621_RS40905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M621_RS40920	COG0582	viral genome integration into host DNA
M621_RS40930	COG1070	Carbohydrate kinase
M621_RS40935	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS40940	COG1879	ABC-type sugar transport system periplasmic component
M621_RS40945	COG1129	ABC transporter
M621_RS40955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M621_RS40965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M621_RS40970	COG3775	system Galactitol-specific IIC component
M621_RS40975	COG3414	Phosphotransferase system galactitol-specific IIB component
M621_RS40990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M621_RS40995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M621_RS41015	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS41025	COG1902	pentaerythritol trinitrate reductase activity
M621_RS41030	COG1881	PFAM PEBP family protein
M621_RS41035	COG2207	Transcriptional regulator
M621_RS41040	COG3118	belongs to the thioredoxin family
M621_RS41045	COG1486	melibiose metabolic process
M621_RS41050	COG0583	DNA-binding transcription factor activity
M621_RS41055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M621_RS41110	COG1881	PFAM PEBP family protein
M621_RS41115	COG2207	Transcriptional regulator
M621_RS41130	COG0583	DNA-binding transcription factor activity
M621_RS41145	COG0583	DNA-binding transcription factor activity
M621_RS41180	COG4774	siderophore transport
M621_RS41185	COG2223	nitrite transmembrane transporter activity
M621_RS41230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M621_RS41245	COG0436	Aminotransferase
M621_RS41265	COG1183	phosphatidylcholine synthase activity
M621_RS41280	COG3238	Protein conserved in bacteria
M621_RS41300	COG0583	DNA-binding transcription factor activity
M621_RS41310	COG0859	PFAM glycosyl transferase family 9
M621_RS41325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS41340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M621_RS41345	COG4172	Belongs to the ABC transporter superfamily
M621_RS41350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M621_RS41355	COG0601	transmembrane transport
M621_RS41375	COG2186	Transcriptional regulator
M621_RS41385	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS41390	COG2271	Major facilitator Superfamily
M621_RS41395	COG1063	alcohol dehydrogenase
M621_RS41400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M621_RS41430	COG0471	metal ion transport
M621_RS41445	COG3051	citrate lyase alpha subunit
M621_RS41450	COG2301	Belongs to the HpcH HpaI aldolase family
M621_RS41455	COG3052	prosthetic group binding
M621_RS41460	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
M621_RS41465	COG4565	transcriptional regulatory protein
M621_RS41490	COG0583	DNA-binding transcription factor activity
M621_RS41500	COG0402	S-adenosylhomocysteine deaminase activity
M621_RS41525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M621_RS41530	COG0277	FAD linked oxidase domain protein
M621_RS41590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M621_RS41600	COG3547	Transposase (IS116 IS110 IS902 family)
M621_RS41605	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS41610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M621_RS41615	COG0508	dehydrogenase complex catalyzes the overall conversion of
M621_RS41620	COG0022	dehydrogenase e1 component
M621_RS41625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M621_RS41635	COG3477	response to acidic pH
M621_RS41640	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M621_RS41645	COG2207	Transcriptional regulator
M621_RS41650	COG2249	NAD(P)H dehydrogenase (quinone) activity
M621_RS41655	COG0583	DNA-binding transcription factor activity
M621_RS41690	COG0559	Belongs to the binding-protein-dependent transport system permease family
M621_RS41735	COG1250	3-hydroxyacyl-CoA dehydrogenase
M621_RS41745	COG2986	histidine ammonia-lyase
M621_RS41760	COG1174	glycine betaine transport
M621_RS41770	COG2814	Major facilitator Superfamily
M621_RS41785	COG1309	transcriptional regulator
M621_RS41805	COG1473	amidohydrolase
M621_RS41810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS41815	COG2926	Belongs to the UPF0265 family
M621_RS41820	COG1289	transmembrane transporter activity
M621_RS41825	COG3023	N-Acetylmuramoyl-L-alanine amidase
M621_RS41850	COG2925	Exonuclease
M621_RS41855	COG0531	amino acid
M621_RS41860	COG0174	glutamine synthetase
M621_RS41865	COG1917	Cupin 2, conserved barrel domain protein
M621_RS41865	COG1396	sequence-specific DNA binding
M621_RS41870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M621_RS41875	COG1129	ABC transporter
M621_RS41880	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS41885	COG4771	TonB-dependent receptor
M621_RS41890	COG1120	ATPase activity
M621_RS41895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M621_RS41905	COG0833	amino acid
M621_RS41910	COG0583	DNA-binding transcription factor activity
M621_RS41915	COG2855	membrane
M621_RS41920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M621_RS41925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M621_RS41925	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M621_RS41925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M621_RS41930	COG1105	Belongs to the carbohydrate kinase PfkB family
M621_RS41940	COG0494	nUDIX hydrolase
M621_RS41945	COG3005	denitrification pathway
M621_RS41950	COG0243	molybdopterin cofactor binding
M621_RS41970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M621_RS41975	COG1312	Catalyzes the dehydration of D-mannonate
M621_RS41980	COG0246	Mannitol dehydrogenase
M621_RS41990	COG0523	cobalamin synthesis protein
M621_RS41995	COG0671	phosphoesterase, PA-phosphatase related
M621_RS42000	COG0791	NLP P60 protein
M621_RS42005	COG2200	EAL domain
M621_RS42010	COG4166	transmembrane transport
M621_RS42015	COG4174	ABC transporter (Permease)
M621_RS42020	COG4239	(ABC) transporter, permease
M621_RS42025	COG4172	Belongs to the ABC transporter superfamily
M621_RS42035	COG2814	Major facilitator Superfamily
M621_RS42040	COG1187	pseudouridine synthase activity
M621_RS42045	COG1061	Type III restriction enzyme res subunit
M621_RS42050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M621_RS42055	COG3081	Nucleoid-associated protein
M621_RS42060	COG3082	Protein of unknown function (DUF1414)
M621_RS42090	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M621_RS42115	COG0346	lactoylglutathione lyase activity
M621_RS42130	COG2223	nitrite transmembrane transporter activity
M621_RS42135	COG2198	Histidine kinase
M621_RS42135	COG0642	Histidine kinase
M621_RS42145	COG0784	Response regulator, receiver
M621_RS42145	COG2205	protein histidine kinase activity
M621_RS42155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M621_RS42160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M621_RS42170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M621_RS42185	COG0814	amino acid
M621_RS42210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M621_RS42215	COG0596	Alpha beta hydrolase
M621_RS42220	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M621_RS42225	COG1169	isochorismate synthase
M621_RS42230	COG3459	Glycosyltransferase 36 associated
M621_RS42235	COG4575	ribosome binding
M621_RS42240	COG1063	alcohol dehydrogenase
M621_RS42245	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS42250	COG1609	Transcriptional regulator
M621_RS42280	COG0028	Belongs to the TPP enzyme family
M621_RS42290	COG1007	ATP synthesis coupled electron transport
M621_RS42295	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M621_RS42300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M621_RS42305	COG0713	ATP synthesis coupled electron transport
M621_RS42310	COG0839	Belongs to the complex I subunit 6 family
M621_RS42320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M621_RS42325	COG1034	ATP synthesis coupled electron transport
M621_RS42340	COG0649	NAD binding
M621_RS42340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M621_RS42345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M621_RS42350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M621_RS42355	COG0583	DNA-binding transcription factor activity
M621_RS42360	COG0436	Aminotransferase
M621_RS42365	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M621_RS42370	COG0490	domain, Protein
M621_RS42370	COG0471	metal ion transport
M621_RS42375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M621_RS42380	COG3013	Belongs to the UPF0304 family
M621_RS42385	COG3092	negative regulation of chromosome organization
M621_RS42390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M621_RS42395	COG0857	belongs to the CobB CobQ family
M621_RS42395	COG0280	phosphate acetyltransferase
M621_RS42400	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M621_RS42405	COG0622	Phosphoesterase
M621_RS42410	COG0625	glutathione transferase activity
M621_RS42415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M621_RS42420	COG1090	epimerase
M621_RS42425	COG4598	ABC transporter
M621_RS42435	COG4215	(ABC) transporter
M621_RS42440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS42445	COG0163	prenyltransferase activity
M621_RS42450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M621_RS42455	COG1286	toxin biosynthetic process
M621_RS42460	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M621_RS42465	COG0285	dihydrofolate synthase activity
M621_RS42470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M621_RS42475	COG0586	Pfam SNARE associated Golgi protein
M621_RS42485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M621_RS42490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M621_RS42500	COG0697	spore germination
M621_RS42505	COG0642	Histidine kinase
M621_RS42545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M621_RS42550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M621_RS42595	COG2195	Cleaves the N-terminal amino acid of tripeptides
M621_RS42600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M621_RS42610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M621_RS42615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS42640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M621_RS42645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M621_RS42645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M621_RS42655	COG3101	peptidyl-lysine hydroxylation
M621_RS42660	COG0730	response to heat
M621_RS42665	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
M621_RS42670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M621_RS42675	COG2890	protein-(glutamine-N5) methyltransferase activity
M621_RS42680	COG2840	Smr protein MutS2
M621_RS42685	COG2062	phosphohistidine phosphatase, SixA
M621_RS42690	COG1024	Enoyl-CoA hydratase
M621_RS42690	COG1250	3-hydroxyacyl-CoA dehydrogenase
M621_RS42695	COG0183	Belongs to the thiolase family
M621_RS42700	COG3691	Protein conserved in bacteria
M621_RS42705	COG2067	long-chain fatty acid transport protein
M621_RS42715	COG3088	subunit of a heme lyase
M621_RS42715	COG4235	cytochrome complex assembly
M621_RS42720	COG3088	subunit of a heme lyase
M621_RS42720	COG4235	cytochrome complex assembly
M621_RS42725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M621_RS42730	COG1138	Cytochrome C-type biogenesis protein
M621_RS42735	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M621_RS42740	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M621_RS42745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M621_RS42750	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M621_RS42760	COG2116	formate transmembrane transporter activity
M621_RS42770	COG0583	DNA-binding transcription factor activity
M621_RS42780	COG0697	spore germination
M621_RS42795	COG2951	lytic endotransglycosylase activity
M621_RS42805	COG1598	PFAM Uncharacterised protein family UPF0150
M621_RS42820	COG3038	cytochrome b561
M621_RS42825	COG0436	Aminotransferase
M621_RS42840	COG3275	phosphorelay sensor kinase activity
M621_RS42845	COG3279	Response regulator of the LytR AlgR family
M621_RS42855	COG2223	nitrite transmembrane transporter activity
M621_RS42870	COG1794	racemase activity, acting on amino acids and derivatives
M621_RS42885	COG3961	Belongs to the TPP enzyme family
M621_RS42890	COG0667	Aldo Keto reductase
M621_RS42900	COG1914	H( )-stimulated, divalent metal cation uptake system
M621_RS42905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M621_RS42920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M621_RS42945	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS42950	COG3433	isochorismatase activity
M621_RS42950	COG1535	isochorismatase
M621_RS42955	COG1021	2,3-dihydroxybenzoate-AMP ligase
M621_RS42960	COG1169	isochorismate synthase
M621_RS42965	COG4592	Periplasmic binding protein
M621_RS42975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M621_RS42980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M621_RS42985	COG1120	ATPase activity
M621_RS42990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M621_RS42990	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M621_RS42995	COG3251	PFAM MbtH domain protein
M621_RS43000	COG2382	esterase
M621_RS43005	COG4771	TonB-dependent receptor
M621_RS43010	COG0747	negative chemotaxis
M621_RS43030	COG4302	ethanolamine ammonia-lyase activity
M621_RS43035	COG4303	Ethanolamine ammonia lyase large subunit
M621_RS43050	COG0583	DNA-binding transcription factor activity
M621_RS43055	COG0385	Bile acid
M621_RS43060	COG3530	Putative quorum-sensing-regulated virulence factor
M621_RS43065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M621_RS43070	COG3115	cell septum assembly
M621_RS43075	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M621_RS43085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M621_RS43090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M621_RS43100	COG2205	protein histidine kinase activity
M621_RS43105	COG0745	RESPONSE REGULATOR receiver
M621_RS43110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS43120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M621_RS43130	COG4208	sulfate ABC transporter
M621_RS43135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M621_RS43140	COG4150	thiosulfate binding
M621_RS43145	COG2837	iron assimilation
M621_RS43160	COG3111	PFAM Bacterial OB fold (BOF) protein
M621_RS43165	COG0456	acetyltransferase
M621_RS43175	COG0408	coproporphyrinogen oxidase activity
M621_RS43190	COG0833	amino acid
M621_RS43195	COG2040	homocysteine
M621_RS43230	COG0583	DNA-binding transcription factor activity
M621_RS43235	COG3397	chitin binding
M621_RS43240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M621_RS43245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M621_RS43250	COG0494	nUDIX hydrolase
M621_RS43255	COG3005	denitrification pathway
M621_RS43260	COG3043	anaerobic respiration
M621_RS43265	COG0243	molybdopterin cofactor binding
M621_RS43270	COG3062	negative regulation of establishment of protein localization
M621_RS43275	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M621_RS43275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M621_RS43280	COG3850	Histidine kinase
M621_RS43285	COG2197	response regulator
M621_RS43295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M621_RS43300	COG4771	TonB-dependent receptor
M621_RS43320	COG0456	acetyltransferase
M621_RS43340	COG1393	Belongs to the ArsC family
M621_RS43345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M621_RS43350	COG1876	peptidase activity
M621_RS43375	COG0400	carboxylic ester hydrolase activity
M621_RS43385	COG2321	neutral zinc metallopeptidase
M621_RS43390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M621_RS43395	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M621_RS43400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M621_RS43405	COG2716	regulation of RNA biosynthetic process
M621_RS43410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M621_RS43415	COG0628	permease
M621_RS43420	COG3781	membrane
M621_RS43425	COG0314	molybdopterin synthase activity
M621_RS43430	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M621_RS43440	COG1294	oxidase, subunit
M621_RS43445	COG1271	oxidase subunit
M621_RS43450	COG2837	iron assimilation
M621_RS43455	COG0542	response to heat
M621_RS43460	COG0243	molybdopterin cofactor binding
M621_RS43495	COG4783	chaperone-mediated protein folding
M621_RS43500	COG1393	Belongs to the ArsC family
M621_RS43510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M621_RS43520	COG2261	transglycosylase associated protein
M621_RS43525	COG2233	PERMEase
M621_RS43530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M621_RS43535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M621_RS43540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M621_RS43545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M621_RS43560	COG3210	domain, Protein
M621_RS43575	COG0573	inorganic phosphate transmembrane transporter activity
M621_RS43580	COG0573	inorganic phosphate transmembrane transporter activity
M621_RS43585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M621_RS43600	COG2239	Acts as a magnesium transporter
M621_RS43605	COG3447	MASE1 domain protein
M621_RS43605	COG5001	Diguanylate cyclase
M621_RS43605	COG5002	protein histidine kinase activity
M621_RS43615	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M621_RS43620	COG0443	Heat shock 70 kDa protein
M621_RS43630	COG2046	Belongs to the sulfate adenylyltransferase family
M621_RS43630	COG0529	Catalyzes the synthesis of activated sulfate
M621_RS43640	COG0667	Aldo Keto reductase
M621_RS43645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS43650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M621_RS43655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M621_RS43660	COG2814	Major facilitator Superfamily
M621_RS43665	COG2205	protein histidine kinase activity
M621_RS43670	COG0745	RESPONSE REGULATOR receiver
M621_RS43675	COG3422	double-strand break repair
M621_RS43680	COG0826	peptidase U32
M621_RS43685	COG1597	lipid kinase activity
M621_RS43690	COG4948	Mandelate Racemase Muconate Lactonizing
M621_RS43695	COG1063	alcohol dehydrogenase
M621_RS43700	COG2271	Major facilitator Superfamily
M621_RS43705	COG0246	Mannitol dehydrogenase
M621_RS43710	COG1802	Transcriptional regulator
M621_RS43715	COG1830	Aldolase
M621_RS43720	COG3730	PTS system glucitol sorbitol-specific
M621_RS43735	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS43740	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
M621_RS43745	COG1349	DNA-binding transcription factor activity
M621_RS43760	COG0351	phosphomethylpyrimidine kinase
M621_RS43765	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M621_RS43770	COG0456	acetyltransferase
M621_RS43785	COG2814	Major facilitator Superfamily
M621_RS43810	COG2197	response regulator
M621_RS43815	COG2198	Histidine kinase
M621_RS43815	COG2205	protein histidine kinase activity
M621_RS43815	COG0784	Response regulator, receiver
M621_RS43825	COG1733	regulation of RNA biosynthetic process
M621_RS43860	COG0519	Catalyzes the synthesis of GMP from XMP
M621_RS43860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M621_RS43865	COG0517	IMP dehydrogenase activity
M621_RS43865	COG0516	GMP reductase activity
M621_RS43870	COG1570	exodeoxyribonuclease VII activity
M621_RS43880	COG2271	Major facilitator Superfamily
M621_RS43885	COG1609	Transcriptional regulator
M621_RS43900	COG1645	bacterial-type flagellum-dependent swarming motility
M621_RS43910	COG1160	GTP binding
M621_RS43915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M621_RS43920	COG2976	Protein conserved in bacteria
M621_RS43925	COG0124	histidyl-tRNA synthetase
M621_RS43930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M621_RS43935	COG1426	Protein conserved in bacteria
M621_RS43945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M621_RS43950	COG0105	UTP biosynthetic process
M621_RS43955	COG4953	penicillin-binding protein 1C
M621_RS43960	COG2373	Large extracellular alpha-helical protein
M621_RS43970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M621_RS43975	COG2975	iron-sulfur cluster assembly
M621_RS43980	COG0633	Ferredoxin
M621_RS43985	COG0443	Heat shock 70 kDa protein
M621_RS43990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M621_RS43995	COG0316	Belongs to the HesB IscA family
M621_RS44000	COG0822	iron-sulfur transferase activity
M621_RS44005	COG1104	cysteine desulfurase activity
M621_RS44010	COG1959	2 iron, 2 sulfur cluster binding
M621_RS44025	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M621_RS44030	COG3683	transport system, periplasmic component
M621_RS44035	COG3711	transcriptional antiterminator
M621_RS44040	COG2814	Major facilitator Superfamily
M621_RS44045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M621_RS44050	COG1017	nitric oxide dioxygenase activity
M621_RS44050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M621_RS44060	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M621_RS44065	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS44070	COG1177	transmembrane transport
M621_RS44075	COG1176	ABC-type spermidine putrescine transport system, permease component I
M621_RS44080	COG3842	ATPase activity
M621_RS44085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M621_RS44100	COG0347	Belongs to the P(II) protein family
M621_RS44105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M621_RS44105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M621_RS44110	COG2204	response regulator
M621_RS44115	COG3170	Tfp pilus assembly protein FimV
M621_RS44120	COG2205	protein histidine kinase activity
M621_RS44135	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M621_RS44150	COG0560	Phosphoserine phosphatase
M621_RS44155	COG1263	PTS System
M621_RS44155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M621_RS44160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M621_RS44165	COG1737	Transcriptional regulator
M621_RS44170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M621_RS44175	COG0736	holo-[acyl-carrier-protein] synthase activity
M621_RS44180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M621_RS44185	COG1381	Involved in DNA repair and RecF pathway recombination
M621_RS44190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M621_RS44195	COG0571	ribonuclease III activity
M621_RS44200	COG0681	Belongs to the peptidase S26 family
M621_RS44205	COG0481	GTPase activity
M621_RS44215	COG3086	response to oxidative stress
M621_RS44235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M621_RS44240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M621_RS44245	COG0513	Belongs to the DEAD box helicase family
M621_RS44260	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M621_RS44265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M621_RS44270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M621_RS44275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M621_RS44280	COG0497	DNA recombination
M621_RS44285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M621_RS44290	COG2914	Belongs to the UPF0125 (RnfH) family
M621_RS44295	COG2867	negative regulation of translational initiation
M621_RS44300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M621_RS44305	COG0582	viral genome integration into host DNA
M621_RS44315	COG4983	Phage plasmid primase, P4 family domain protein
M621_RS44330	COG1061	Type III restriction enzyme res subunit
M621_RS44340	COG3596	GTP binding
M621_RS44350	COG2378	regulation of single-species biofilm formation
M621_RS44455	COG0583	DNA-binding transcription factor activity
M621_RS44460	COG0667	Aldo Keto reductase
M621_RS44465	COG3713	MltA-interacting MipA family protein
M621_RS44480	COG2226	methyltransferase
M621_RS44490	COG2388	GCN5-related N-acetyl-transferase
M621_RS44495	COG2259	Doxx family
M621_RS44515	COG0477	Major facilitator Superfamily
M621_RS44530	COG0583	DNA-binding transcription factor activity
M621_RS44555	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M621_RS44560	COG4575	ribosome binding
M621_RS44570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M621_RS44575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M621_RS44580	COG1780	Probably involved in ribonucleotide reductase function
M621_RS44600	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS44610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M621_RS44620	COG3493	citrate carrier protein
M621_RS44640	COG4176	ABC-type proline glycine betaine transport system permease component
M621_RS44645	COG2113	Glycine betaine
M621_RS44650	COG0583	DNA-binding transcription factor activity
M621_RS44655	COG2814	Major facilitator Superfamily
M621_RS44665	COG1846	Transcriptional regulator
M621_RS44675	COG1566	PFAM secretion protein HlyD family protein
M621_RS44680	COG2814	Major facilitator Superfamily
M621_RS44685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M621_RS44690	COG3118	belongs to the thioredoxin family
M621_RS44695	COG3148	PFAM DTW domain containing protein
M621_RS44700	COG0045	succinate-CoA ligase (ADP-forming) activity
M621_RS44700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M621_RS44700	COG1042	CoA-binding domain protein
M621_RS44705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M621_RS44710	COG5544	Lipoprotein
M621_RS44715	COG0477	Major facilitator Superfamily
M621_RS44745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M621_RS44755	COG2011	ABC-type metal ion transport system permease component
M621_RS44770	COG1720	tRNA m6t6A37 methyltransferase activity
M621_RS44775	COG0442	prolyl-tRNA aminoacylation
M621_RS44780	COG3015	lipoprotein NlpE involved in copper resistance
M621_RS44785	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M621_RS44800	COG4568	rho-dependent transcription termination
M621_RS44810	COG0037	tRNA processing
M621_RS44815	COG0346	lactoylglutathione lyase activity
M621_RS44820	COG1982	Orn Lys Arg decarboxylase major
M621_RS44825	COG0825	malonyl-CoA metabolic process
M621_RS44835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M621_RS44840	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M621_RS44845	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M621_RS44850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M621_RS44855	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M621_RS44860	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M621_RS44865	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M621_RS44870	COG0750	zinc metalloprotease
M621_RS44875	COG0575	Belongs to the CDS family
M621_RS44880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M621_RS44885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M621_RS44890	COG0233	cytoplasmic translational termination
M621_RS44895	COG0528	UMP kinase activity
M621_RS44900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M621_RS44905	COG0052	Belongs to the universal ribosomal protein uS2 family
M621_RS44915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M621_RS44935	COG0564	pseudouridine synthase activity
M621_RS44940	COG3098	single-species biofilm formation
M621_RS44945	COG2814	Major facilitator Superfamily
M621_RS44960	COG1611	Belongs to the LOG family
M621_RS44965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M621_RS44970	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M621_RS44975	COG2363	Small membrane protein
M621_RS44980	COG0583	DNA-binding transcription factor activity
M621_RS44990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M621_RS44995	COG2166	iron-sulfur cluster assembly
M621_RS45000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M621_RS45005	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M621_RS45025	COG0860	N-Acetylmuramoyl-L-alanine amidase
M621_RS45030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M621_RS45030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M621_RS45035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M621_RS45040	COG1074	ATP-dependent DNA helicase activity
M621_RS45045	COG1025	Belongs to the peptidase M16 family
M621_RS45050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M621_RS45075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M621_RS45080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M621_RS45090	COG0494	nUDIX hydrolase
M621_RS45095	COG3066	DNA modification
M621_RS45100	COG0861	Integral membrane protein TerC family
M621_RS45110	COG0667	Aldo Keto reductase
M621_RS45115	COG0477	Major facilitator Superfamily
M621_RS45120	COG0204	Acyl-transferase
M621_RS45120	COG0318	PFAM AMP-dependent synthetase and ligase
M621_RS45130	COG1609	Transcriptional regulator
M621_RS45140	COG1609	Transcriptional regulator
M621_RS45150	COG0583	DNA-binding transcription factor activity
M621_RS45155	COG2814	Major facilitator Superfamily
M621_RS45160	COG0583	DNA-binding transcription factor activity
M621_RS45180	COG4178	(ABC) transporter
M621_RS45185	COG2807	transmembrane transport
M621_RS45190	COG4615	Cyclic peptide transporter
M621_RS45195	COG0582	viral genome integration into host DNA
M621_RS45200	COG2197	response regulator
M621_RS45205	COG2197	response regulator
M621_RS45210	COG3539	Fimbrial protein
M621_RS45225	COG3121	Chaperone
M621_RS45230	COG3539	Fimbrial protein
M621_RS45235	COG0582	viral genome integration into host DNA
M621_RS45245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M621_RS45250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M621_RS45255	COG1538	Outer membrane efflux protein
M621_RS45265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M621_RS45290	COG0583	DNA-binding transcription factor activity
M621_RS45295	COG1304	FMN binding
M621_RS45300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M621_RS45305	COG1309	transcriptional regulator
M621_RS45315	COG1942	4-Oxalocrotonate Tautomerase
M621_RS45320	COG5265	(ABC) transporter
M621_RS45340	COG4942	peptidase
M621_RS45345	COG3247	response to pH
M621_RS45350	COG0484	heat shock protein binding
M621_RS45360	COG1278	Cold shock
M621_RS45370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M621_RS45375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M621_RS45380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M621_RS45385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M621_RS45390	COG4974	Belongs to the 'phage' integrase family
M621_RS45395	COG0716	FMN binding
M621_RS45400	COG4452	Inner membrane protein CreD
M621_RS45405	COG2205	protein histidine kinase activity
M621_RS45410	COG0745	RESPONSE REGULATOR receiver
M621_RS45420	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M621_RS45425	COG0354	folic acid binding
M621_RS45435	COG1272	protein, Hemolysin III
M621_RS45475	COG3713	MltA-interacting MipA family protein
M621_RS45495	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M621_RS45495	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M621_RS45500	COG0509	glycine decarboxylation via glycine cleavage system
M621_RS45505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M621_RS45510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M621_RS45515	COG1509	lysine 2,3-aminomutase activity
M621_RS45530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M621_RS45535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M621_RS45540	COG0006	proline dipeptidase activity
M621_RS45545	COG3079	Belongs to the UPF0149 family
M621_RS45550	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M621_RS45555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M621_RS45560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M621_RS45565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M621_RS45570	COG0583	DNA-binding transcription factor activity
M621_RS45580	COG1279	arginine transmembrane transporter activity
M621_RS45585	COG1414	Transcriptional regulator
M621_RS45590	COG1129	ABC transporter
M621_RS45595	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS45615	COG2731	YhcH YjgK YiaL family protein
M621_RS45625	COG1070	Carbohydrate kinase
M621_RS45630	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M621_RS45635	COG3623	hexulose-6-phosphate isomerase
M621_RS45640	COG0235	Class ii aldolase
M621_RS45650	COG3122	Protein conserved in bacteria
M621_RS45665	COG0191	fructose-bisphosphate aldolase activity
M621_RS45670	COG0126	phosphoglycerate kinase activity
M621_RS45675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M621_RS45685	COG3842	ATPase activity
M621_RS45690	COG1175	transmembrane transport
M621_RS45700	COG0406	alpha-ribazole phosphatase activity
M621_RS45705	COG0471	metal ion transport
M621_RS45710	COG0583	DNA-binding transcription factor activity
M621_RS45715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M621_RS45720	COG0501	Belongs to the peptidase M48B family
M621_RS45735	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
M621_RS45740	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS45755	COG2271	Major facilitator Superfamily
M621_RS45770	COG1414	Transcriptional regulator
M621_RS45790	COG2146	nitrite reductase [NAD(P)H] activity
M621_RS45795	COG1187	pseudouridine synthase activity
M621_RS45800	COG0010	Belongs to the arginase family
M621_RS45805	COG1166	arginine decarboxylase activity
M621_RS45810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M621_RS45820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M621_RS45825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M621_RS45830	COG1120	ATPase activity
M621_RS45835	COG4774	siderophore transport
M621_RS45840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M621_RS45845	COG1643	Atp-dependent helicase
M621_RS45850	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M621_RS45855	COG1489	DNA binding
M621_RS45865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M621_RS45875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M621_RS45880	COG0642	Histidine kinase
M621_RS45885	COG0745	RESPONSE REGULATOR receiver
M621_RS45890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M621_RS45895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M621_RS45900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M621_RS45905	COG0726	polysaccharide deacetylase
M621_RS45910	COG0842	Transport permease protein
M621_RS45915	COG1131	(ABC) transporter
M621_RS45920	COG0288	reversible hydration of carbon dioxide
M621_RS45930	COG2132	Multicopper oxidase
M621_RS45940	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M621_RS45945	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M621_RS45950	COG3112	Uncharacterised protein family (UPF0231)
M621_RS45960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M621_RS45965	COG0508	dehydrogenase complex catalyzes the overall conversion of
M621_RS45970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M621_RS45975	COG2186	Transcriptional regulator
M621_RS45980	COG1113	amino acid transport
M621_RS45985	COG2211	Major facilitator Superfamily
M621_RS45990	COG3940	Belongs to the glycosyl hydrolase 43 family
M621_RS45995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M621_RS45995	COG2010	Cytochrome c
M621_RS46005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M621_RS46015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M621_RS46020	COG3708	Transcriptional regulator
M621_RS46020	COG2207	Transcriptional regulator
M621_RS46025	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M621_RS46025	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M621_RS46030	COG3091	SprT-like family
M621_RS46035	COG2356	endonuclease I
M621_RS46040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M621_RS46045	COG0189	ligase activity
M621_RS46050	COG1678	Uncharacterized ACR, COG1678
M621_RS46055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M621_RS46060	COG2805	Type II/IV secretion system protein
M621_RS46065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M621_RS46070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M621_RS46075	COG0762	integral membrane protein
M621_RS46080	COG1872	DUF167
M621_RS46085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M621_RS46090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M621_RS46110	COG2066	Belongs to the glutaminase family
M621_RS46115	COG3171	Protein conserved in bacteria
M621_RS46120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M621_RS46125	COG1194	a g-specific adenine glycosylase
M621_RS46130	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M621_RS46135	COG0741	lytic transglycosylase activity
M621_RS46140	COG1982	Orn Lys Arg decarboxylase major
M621_RS46165	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS46175	COG0583	DNA-binding transcription factor activity
M621_RS46180	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS46185	COG2990	Protein conserved in bacteria
M621_RS46230	COG5002	protein histidine kinase activity
M621_RS46235	COG0745	RESPONSE REGULATOR receiver
M621_RS46245	COG2990	Protein conserved in bacteria
M621_RS46280	COG2197	response regulator
M621_RS46285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS46285	COG2205	protein histidine kinase activity
M621_RS46350	COG3547	Transposase (IS116 IS110 IS902 family)
M621_RS46365	COG0745	RESPONSE REGULATOR receiver
M621_RS46405	COG0475	glutathione-regulated potassium exporter activity
M621_RS46445	COG1506	peptidase
M621_RS46445	COG0823	Involved in the tonB-independent uptake of proteins
M621_RS46455	COG1131	(ABC) transporter
M621_RS46480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M621_RS46485	COG3320	Male sterility
M621_RS46485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M621_RS46490	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS46495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M621_RS46495	COG2070	2-Nitropropane dioxygenase
M621_RS46500	COG4221	oxidoreductase activity
M621_RS46500	COG3321	synthase
M621_RS46500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M621_RS46500	COG0300	oxidoreductase activity
M621_RS46520	COG1136	(ABC) transporter
M621_RS46525	COG1566	PFAM secretion protein HlyD family protein
M621_RS46540	COG0076	glutamate decarboxylase activity
M621_RS46560	COG0309	Hydrogenase expression formation protein (HypE)
M621_RS46565	COG0409	Hydrogenase expression formation protein
M621_RS46570	COG0298	carbon dioxide binding
M621_RS46575	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M621_RS46580	COG0375	protein maturation
M621_RS46590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M621_RS46595	COG0651	ATP synthesis coupled electron transport
M621_RS46600	COG0650	Formate hydrogenlyase subunit 4
M621_RS46605	COG3261	NADH dehydrogenase
M621_RS46605	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
M621_RS46610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M621_RS46615	COG3260	NADH ubiquinone oxidoreductase 20
M621_RS46625	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M621_RS46630	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M621_RS46635	COG3383	formate dehydrogenase (NAD+) activity
M621_RS46640	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
M621_RS46645	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M621_RS46685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M621_RS46685	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M621_RS46730	COG3210	domain, Protein
M621_RS46735	COG2994	toxin metabolic process
M621_RS46740	COG2831	hemolysin activation secretion protein
M621_RS46770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M621_RS46780	COG3609	addiction module antidote protein, CC2985 family
M621_RS46785	COG0848	biopolymer transport protein
M621_RS46805	COG0675	Transposase, IS605 OrfB family
M621_RS46810	COG0586	Pfam SNARE associated Golgi protein
M621_RS46815	COG0583	DNA-binding transcription factor activity
M621_RS46825	COG2207	Transcriptional regulator
M621_RS46830	COG1979	alcohol dehydrogenase
M621_RS46835	COG0656	L-ascorbic acid biosynthetic process
M621_RS46840	COG2723	6-phospho-beta-galactosidase activity
M621_RS46845	COG1447	Phosphotransferase system cellobiose-specific component IIA
M621_RS46850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M621_RS46860	COG0741	lytic transglycosylase activity
M621_RS46875	COG2132	Multicopper oxidase
M621_RS46885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M621_RS46890	COG2249	NAD(P)H dehydrogenase (quinone) activity
M621_RS46895	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M621_RS46900	COG0583	DNA-binding transcription factor activity
M621_RS46910	COG3150	esterase
M621_RS46915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M621_RS46920	COG3151	Protein conserved in bacteria
M621_RS46925	COG0494	nUDIX hydrolase
M621_RS46930	COG1538	Outer membrane efflux protein
M621_RS46945	COG1461	Dihydroxyacetone kinase
M621_RS46950	COG2376	Dihydroxyacetone kinase
M621_RS46960	COG5463	Belongs to the UPF0441 family
M621_RS46965	COG0754	glutathionylspermidine amidase activity
M621_RS46970	COG3384	dioxygenase
M621_RS46985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M621_RS46990	COG2960	long-chain fatty acid transporting porin activity
M621_RS46995	COG0531	amino acid
M621_RS47000	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M621_RS47000	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M621_RS47005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M621_RS47010	COG3025	triphosphatase activity
M621_RS47015	COG4991	sh3 domain protein
M621_RS47020	COG0617	tRNA 3'-terminal CCA addition
M621_RS47025	COG1968	undecaprenyl-diphosphatase activity
M621_RS47030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M621_RS47035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M621_RS47040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M621_RS47045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M621_RS47050	COG0358	DNA primase activity
M621_RS47060	COG3663	DNA glycosylase
M621_RS47075	COG4220	transposase activity
M621_RS47095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M621_RS47115	COG0625	glutathione transferase activity
M621_RS47125	COG1012	belongs to the aldehyde dehydrogenase family
M621_RS47130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M621_RS47145	COG1902	pentaerythritol trinitrate reductase activity
M621_RS47145	COG0446	pyridine nucleotide-disulphide oxidoreductase
M621_RS47150	COG2813	Specifically methylates the guanine in position
M621_RS47155	COG1451	nucleotide metabolic process
M621_RS47160	COG0673	inositol 2-dehydrogenase activity
M621_RS47170	COG0861	Integral membrane protein TerC family
M621_RS47175	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M621_RS47185	COG2721	sulfolactate sulfo-lyase activity
M621_RS47190	COG1904	glucuronate isomerase
M621_RS47210	COG0586	Pfam SNARE associated Golgi protein
M621_RS47215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M621_RS47225	COG4575	ribosome binding
M621_RS47230	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
M621_RS47240	COG2259	Doxx family
M621_RS47245	COG0435	Glutathione S-transferase
M621_RS47250	COG0583	DNA-binding transcription factor activity
M621_RS47255	COG1741	Belongs to the pirin family
M621_RS47260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M621_RS47265	COG3107	peptidoglycan biosynthetic process
M621_RS47270	COG0792	nuclease activity
M621_RS47275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M621_RS47280	COG2823	Periplasmic or secreted lipoprotein
M621_RS47290	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M621_RS47295	COG5002	protein histidine kinase activity
M621_RS47295	COG0784	Response regulator, receiver
M621_RS47295	COG2198	Histidine kinase
M621_RS47300	COG1242	4 iron, 4 sulfur cluster binding
M621_RS47305	COG0069	glutamate synthase activity
M621_RS47305	COG0067	glutamate synthase
M621_RS47305	COG0070	glutamate synthase
M621_RS47310	COG0493	'glutamate synthase
M621_RS47315	COG2969	positive regulation of protein catabolic process
M621_RS47320	COG0625	glutathione transferase activity
M621_RS47325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M621_RS47330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M621_RS47335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M621_RS47340	COG3105	Protein conserved in bacteria
M621_RS47345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M621_RS47350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M621_RS47355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M621_RS47360	COG5007	Belongs to the BolA IbaG family
M621_RS47365	COG3113	response to antibiotic
M621_RS47370	COG2854	intermembrane phospholipid transfer
M621_RS47375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M621_RS47380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M621_RS47385	COG1127	ABC transporter
M621_RS47390	COG0530	calcium, potassium:sodium antiporter activity
M621_RS47395	COG0517	IMP dehydrogenase activity
M621_RS47395	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M621_RS47400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M621_RS47405	COG3117	lipopolysaccharide transmembrane transporter activity
M621_RS47410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M621_RS47415	COG1137	ATPase activity
M621_RS47420	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M621_RS47435	COG1660	Displays ATPase and GTPase activities
M621_RS47440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M621_RS47445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M621_RS47445	COG3711	transcriptional antiterminator
M621_RS47450	COG2706	6-phosphogluconolactonase activity
M621_RS47465	COG3964	amidohydrolase
M621_RS47495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M621_RS47505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M621_RS47515	COG2207	Transcriptional regulator
M621_RS47520	COG3783	Cytochrome b(562)
M621_RS47525	COG0312	modulator of DNA gyrase
M621_RS47530	COG3028	Belongs to the UPF0307 family
M621_RS47535	COG2732	(Barnase) inhibitor
M621_RS47545	COG1289	transmembrane transporter activity
M621_RS47550	COG1566	PFAM secretion protein HlyD family protein
M621_RS47560	COG0583	DNA-binding transcription factor activity
M621_RS47585	COG3210	domain, Protein
M621_RS47600	COG3210	domain, Protein
M621_RS47625	COG0312	modulator of DNA gyrase
M621_RS47630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M621_RS47635	COG3164	Protein of unknown function
M621_RS47640	COG1530	ribonuclease E activity
M621_RS47645	COG0424	maF-like protein
M621_RS47650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M621_RS47655	COG1792	Involved in formation and maintenance of cell shape
M621_RS47660	COG1077	Cell shape determining protein MreB Mrl
M621_RS47665	COG2199	diguanylate cyclase activity
M621_RS47665	COG2200	EAL domain
M621_RS47670	COG0604	alcohol dehydrogenase
M621_RS47675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M621_RS47680	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M621_RS47685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M621_RS47690	COG0511	ligase activity, forming carbon-carbon bonds
M621_RS47695	COG0439	Biotin carboxylase
M621_RS47700	COG3924	membrane
M621_RS47705	COG4145	pantothenate transmembrane transporter activity
M621_RS47710	COG2264	protein methyltransferase activity
M621_RS47800	COG1560	Kdo2-lipid A biosynthetic process
M621_RS47815	COG1380	Effector of murein hydrolase LrgA
M621_RS47820	COG0583	DNA-binding transcription factor activity
M621_RS47825	COG0025	NhaP-type Na H and K H
M621_RS47830	COG2252	PERMEase
M621_RS47840	COG0625	glutathione transferase activity
M621_RS47850	COG0583	DNA-binding transcription factor activity
M621_RS47855	COG1028	Short-chain dehydrogenase reductase Sdr
M621_RS47860	COG0629	single-stranded DNA binding
M621_RS47865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M621_RS47870	COG1064	alcohol dehydrogenase
M621_RS47875	COG0110	maltose O-acetyltransferase activity
M621_RS47880	COG2315	Protein conserved in bacteria
M621_RS47890	COG1448	Aminotransferase
M621_RS47900	COG1522	sequence-specific DNA binding
M621_RS47905	COG1113	amino acid transport
M621_RS47925	COG0604	alcohol dehydrogenase
M621_RS47935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M621_RS47945	COG1595	DNA-templated transcription, initiation
M621_RS47955	COG0735	belongs to the Fur family
M621_RS47960	COG3237	CsbD-like
M621_RS47965	COG0534	Mate efflux family protein
M621_RS47970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M621_RS47975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M621_RS47980	COG2937	Belongs to the GPAT DAPAT family
M621_RS47985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M621_RS47990	COG3161	chorismate lyase activity
M621_RS47995	COG0477	Major facilitator Superfamily
M621_RS48000	COG1609	Transcriptional regulator
M621_RS48015	COG4580	involved in the transport of maltose and maltodextrins
M621_RS48025	COG0366	Alpha amylase catalytic
M621_RS48030	COG2182	Extracellular solute-binding protein
M621_RS48035	COG1175	transmembrane transport
M621_RS48040	COG3833	ABC-type maltose transport systems, permease component
M621_RS48045	COG3223	Belongs to the PsiE family
M621_RS48055	COG0166	Belongs to the GPI family
M621_RS48065	COG0527	aspartate kinase activity
M621_RS48085	COG1283	sodium-dependent phosphate transmembrane transporter activity
M621_RS48090	COG3842	ATPase activity
M621_RS48100	COG4149	molybdate abc transporter
M621_RS48115	COG2188	Transcriptional regulator
M621_RS48125	COG1414	Transcriptional regulator
M621_RS48130	COG3265	gluconokinase activity
M621_RS48135	COG2610	gluconate transmembrane transporter activity
M621_RS48140	COG0129	dihydroxy-acid dehydratase activity
M621_RS48145	COG0800	Aldolase
M621_RS48150	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M621_RS48155	COG2224	Isocitrate lyase
M621_RS48160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M621_RS48165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M621_RS48200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M621_RS48205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M621_RS48210	COG0009	L-threonylcarbamoyladenylate synthase
M621_RS48215	COG0551	DNA topoisomerase type I activity
M621_RS48220	COG2922	Belongs to the Smg family
M621_RS48225	COG0758	DNA mediated transformation
M621_RS48230	COG0242	peptide deformylase activity
M621_RS48235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M621_RS48240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M621_RS48240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M621_RS48245	COG0569	domain protein
M621_RS48250	COG1970	mechanosensitive ion channel activity
M621_RS48255	COG3036	rescue of stalled ribosome
M621_RS48260	COG0789	Transcriptional regulator
M621_RS48270	COG0203	ribosomal protein L17
M621_RS48275	COG0202	RNA polymerase activity
M621_RS48280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M621_RS48285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M621_RS48290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M621_RS48295	COG0201	protein transport
M621_RS48300	COG0200	Binds to the 23S rRNA
M621_RS48305	COG1841	ribosomal large subunit assembly
M621_RS48310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M621_RS48315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M621_RS48320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M621_RS48325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M621_RS48330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M621_RS48335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M621_RS48340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M621_RS48345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M621_RS48350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M621_RS48355	COG0255	Belongs to the universal ribosomal protein uL29 family
M621_RS48360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M621_RS48365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M621_RS48375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M621_RS48385	COG0089	rRNA binding
M621_RS48390	COG0088	Forms part of the polypeptide exit tunnel
M621_RS48395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M621_RS48400	COG0051	transcription antitermination factor activity, RNA binding
M621_RS48415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M621_RS48420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M621_RS48425	COG0049	tRNA binding
M621_RS48430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M621_RS48435	COG2168	tRNA wobble position uridine thiolation
M621_RS48440	COG2923	Belongs to the DsrF TusC family
M621_RS48445	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M621_RS48450	COG2964	Protein conserved in bacteria
M621_RS48455	COG0545	Peptidyl-prolyl cis-trans isomerase
M621_RS48460	COG2900	Belongs to the SlyX family
M621_RS48465	COG1047	Peptidyl-prolyl cis-trans
M621_RS48470	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M621_RS48480	COG2249	NAD(P)H dehydrogenase (quinone) activity
M621_RS48485	COG0488	(ABC) transporter
M621_RS48490	COG2175	clavaminate synthase activity
M621_RS48495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M621_RS48505	COG4521	taurine ABC transporter
M621_RS48520	COG0429	hydrolase of the alpha beta-hydrolase fold
M621_RS48525	COG3089	Belongs to the UPF0270 family
M621_RS48530	COG3954	Phosphoribulokinase
M621_RS48535	COG1765	OsmC-like protein
M621_RS48540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M621_RS48545	COG1289	transmembrane transporter activity
M621_RS48560	COG0433	COG0433 Predicted ATPase
M621_RS48580	COG3275	phosphorelay sensor kinase activity
M621_RS48585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M621_RS48590	COG1447	Phosphotransferase system cellobiose-specific component IIA
M621_RS48595	COG1486	melibiose metabolic process
M621_RS48600	COG1609	Transcriptional regulator
M621_RS48605	COG0738	Major facilitator superfamily
M621_RS48610	COG0402	S-adenosylhomocysteine deaminase activity
M621_RS48615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M621_RS48630	COG1648	precorrin-2 dehydrogenase activity
M621_RS48630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M621_RS48635	COG0180	Tryptophanyl-tRNA synthetase
M621_RS48640	COG0546	phosphoglycolate phosphatase activity
M621_RS48660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M621_RS48665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M621_RS48670	COG4796	Type ii and iii secretion system protein
M621_RS48695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M621_RS48700	COG0494	nUDIX hydrolase
M621_RS48710	COG1011	Hydrolase
M621_RS48715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M621_RS48720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M621_RS48750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M621_RS48755	COG2183	response to ionizing radiation
M621_RS48760	COG1918	ferrous iron import across plasma membrane
M621_RS48780	COG2267	carboxylic ester hydrolase activity
M621_RS48785	COG1040	competence protein
M621_RS48790	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M621_RS48790	COG0316	Belongs to the HesB IscA family
M621_RS48795	COG1640	4-alpha-glucanotransferase
M621_RS48800	COG0058	SHG alpha-glucan phosphorylase activity
M621_RS48805	COG2909	trisaccharide binding
M621_RS48810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M621_RS48815	COG2271	Major facilitator Superfamily
M621_RS48820	COG2731	YhcH YjgK YiaL family protein
M621_RS48830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M621_RS48835	COG0705	Rhomboid family
M621_RS48840	COG1349	DNA-binding transcription factor activity
M621_RS48845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M621_RS48850	COG0058	SHG alpha-glucan phosphorylase activity
M621_RS48855	COG0297	glycogen (starch) synthase activity
M621_RS48860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M621_RS48865	COG1523	belongs to the glycosyl hydrolase 13 family
M621_RS48870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M621_RS48875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M621_RS48880	COG2095	MarC family integral membrane protein
M621_RS48885	COG3265	gluconokinase activity
M621_RS48890	COG2610	gluconate transmembrane transporter activity
M621_RS48895	COG1609	Transcriptional regulator
M621_RS48900	COG1741	Belongs to the pirin family
M621_RS48905	COG1247	-acetyltransferase
M621_RS48910	COG3191	aminopeptidase activity
M621_RS48915	COG1082	Xylose isomerase domain protein TIM barrel
M621_RS48920	COG1082	Xylose isomerase domain protein TIM barrel
M621_RS48925	COG0673	inositol 2-dehydrogenase activity
M621_RS48930	COG3962	Belongs to the TPP enzyme family
M621_RS48940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M621_RS48950	COG3718	enzyme involved in inositol metabolism
M621_RS48960	COG0477	Major facilitator Superfamily
M621_RS48960	COG2814	Major facilitator Superfamily
M621_RS48970	COG0390	transport system, permease component
M621_RS48975	COG4619	ABC transporter
M621_RS49005	COG3188	usher protein
M621_RS49035	COG2197	response regulator
M621_RS49065	COG3008	intermembrane lipid transfer
M621_RS49065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M621_RS49070	COG2995	paraquat-inducible protein a
M621_RS49090	COG2081	HI0933 family
M621_RS49095	COG0306	phosphate transporter
M621_RS49105	COG0589	response to stress
M621_RS49120	COG1129	ABC transporter
M621_RS49125	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS49130	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS49140	COG0517	IMP dehydrogenase activity
M621_RS49140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M621_RS49145	COG0742	ribosomal rna small subunit methyltransferase
M621_RS49150	COG0339	signal peptide processing
M621_RS49165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M621_RS49170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M621_RS49220	COG3121	Chaperone
M621_RS49225	COG3188	usher protein
M621_RS49255	COG3210	domain, Protein
M621_RS49260	COG2831	hemolysin activation secretion protein
M621_RS49265	COG2318	DinB family
M621_RS49285	COG2205	protein histidine kinase activity
M621_RS49285	COG0784	Response regulator, receiver
M621_RS49305	COG1309	transcriptional regulator
M621_RS49310	COG5441	Belongs to the UPF0261 family
M621_RS49315	COG5564	TIM-barrel signal transduction protein
M621_RS49320	COG3678	ATP-independent chaperone mediated protein folding
M621_RS49325	COG5001	Diguanylate cyclase
M621_RS49330	COG1024	Enoyl-CoA hydratase
M621_RS49340	COG1295	ribonuclease BN
M621_RS49345	COG0477	Major facilitator Superfamily
M621_RS49350	COG2134	cdp-diacylglycerol pyrophosphatase
M621_RS49355	COG2982	Protein involved in outer membrane biogenesis
M621_RS49360	COG2200	EAL domain
M621_RS49365	COG1942	4-Oxalocrotonate Tautomerase
M621_RS49370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M621_RS49375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M621_RS49380	COG0583	DNA-binding transcription factor activity
M621_RS49390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M621_RS49395	COG0129	dihydroxy-acid dehydratase activity
M621_RS49400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M621_RS49405	COG3978	acetolactate synthase activity
M621_RS49415	COG2814	Major facilitator Superfamily
M621_RS49420	COG0606	chelatase, subunit chli
M621_RS49425	COG3085	chromosome segregation
M621_RS49430	COG0583	DNA-binding transcription factor activity
M621_RS49435	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS49440	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS49445	COG1129	ABC transporter
M621_RS49450	COG1879	ABC-type sugar transport system periplasmic component
M621_RS49490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M621_RS49495	COG4206	TonB-dependent receptor
M621_RS49500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M621_RS49515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M621_RS49525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M621_RS49525	COG0678	peroxiredoxin activity
M621_RS49530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M621_RS49535	COG0165	Argininosuccinate lyase
M621_RS49540	COG0137	argininosuccinate synthase activity
M621_RS49545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M621_RS49560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M621_RS49580	COG0527	aspartate kinase activity
M621_RS49580	COG0460	homoserine dehydrogenase
M621_RS49585	COG0626	cystathionine gamma-synthase activity
M621_RS49590	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
M621_RS49595	COG0254	rRNA binding
M621_RS49600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M621_RS49605	COG1609	Transcriptional regulator
M621_RS49610	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M621_RS49615	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M621_RS49620	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M621_RS49625	COG1575	Belongs to the MenA family. Type 1 subfamily
M621_RS49630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M621_RS49635	COG3074	FtsZ-dependent cytokinesis
M621_RS49640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M621_RS49650	COG1494	fructose-1,6-bisphosphatase
M621_RS49655	COG2814	Major facilitator Superfamily
M621_RS49670	COG3152	Membrane
M621_RS49680	COG0149	triose-phosphate isomerase activity
M621_RS49685	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M621_RS49690	COG0205	6-phosphofructokinase activity
M621_RS49695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M621_RS49700	COG3678	ATP-independent chaperone mediated protein folding
M621_RS49705	COG0745	RESPONSE REGULATOR receiver
M621_RS49710	COG2205	protein histidine kinase activity
M621_RS49715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M621_RS49730	COG1045	serine acetyltransferase
M621_RS49735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M621_RS49745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M621_RS49750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M621_RS49755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M621_RS49760	COG4942	peptidase
M621_RS49765	COG2861	carbohydrate metabolic process
M621_RS49770	COG1063	alcohol dehydrogenase
M621_RS49775	COG0156	8-amino-7-oxononanoate synthase activity
M621_RS49780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M621_RS49785	COG0859	PFAM glycosyl transferase family 9
M621_RS49790	COG0859	PFAM glycosyl transferase family 9
M621_RS49795	COG0438	transferase activity, transferring glycosyl groups
M621_RS49800	COG3307	-O-antigen
M621_RS49805	COG1216	Glycosyl transferase, family 2
M621_RS49805	COG1442	glycosyl transferase family 8
M621_RS49820	COG0859	PFAM glycosyl transferase family 9
M621_RS49825	COG0438	transferase activity, transferring glycosyl groups
M621_RS49830	COG0438	transferase activity, transferring glycosyl groups
M621_RS49840	COG1519	Transferase
M621_RS49855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M621_RS49865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M621_RS49870	COG2003	Belongs to the UPF0758 family
M621_RS49875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M621_RS49880	COG0756	dUTP diphosphatase activity
M621_RS49885	COG1309	transcriptional regulator
M621_RS49890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M621_RS49895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M621_RS49900	COG1561	YicC-like family, N-terminal region
M621_RS49910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M621_RS49920	COG2860	membrane
M621_RS49925	COG0583	DNA-binding transcription factor activity
M621_RS49940	COG0194	GDP metabolic process
M621_RS49945	COG1758	RNA polymerase activity
M621_RS49950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M621_RS49955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M621_RS49960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M621_RS49965	COG0786	glutamate:sodium symporter activity
M621_RS49970	COG2233	PERMEase
M621_RS49975	COG2982	Protein involved in outer membrane biogenesis
M621_RS49980	COG0456	acetyltransferase
M621_RS49985	COG1490	D-aminoacyl-tRNA deacylase activity
M621_RS49990	COG1295	ribonuclease BN
M621_RS49995	COG1011	Hydrolase
M621_RS50010	COG3852	Histidine kinase
M621_RS50025	COG3078	GTPase activator activity
M621_RS50035	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M621_RS50040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M621_RS50040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M621_RS50045	COG0204	Acyl-transferase
M621_RS50050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M621_RS50055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M621_RS50060	COG3084	Protein conserved in bacteria
M621_RS50065	COG0746	molybdenum cofactor guanylyltransferase activity
M621_RS50070	COG1763	Mo-molybdopterin cofactor biosynthetic process
M621_RS50095	COG2186	Transcriptional regulator
M621_RS50100	COG0477	Major facilitator Superfamily
M621_RS50105	COG1609	Transcriptional regulator
M621_RS50110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M621_RS50120	COG1172	Belongs to the binding-protein-dependent transport system permease family
M621_RS50125	COG1129	ABC transporter
M621_RS50130	COG1869	D-ribose catabolic process
M621_RS50135	COG3158	transport of potassium into the cell
M621_RS50140	COG0714	Associated with various cellular activities
M621_RS50145	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M621_RS50150	COG2502	aspartate--ammonia ligase
M621_RS50155	COG1522	sequence-specific DNA binding
M621_RS50160	COG0716	FMN binding
M621_RS50165	COG0445	tRNA wobble uridine modification
M621_RS50170	COG0357	Ribosomal RNA small subunit methyltransferase G
M621_RS50175	COG3312	ion transport
M621_RS50190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M621_RS50195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M621_RS50200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M621_RS50205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M621_RS50210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M621_RS50215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M621_RS50220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M621_RS50235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M621_RS50240	COG0573	inorganic phosphate transmembrane transporter activity
M621_RS50245	COG0581	inorganic phosphate transmembrane transporter activity
M621_RS50260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M621_RS50265	COG0765	amino acid transport
M621_RS50270	COG0765	amino acid transport
M621_RS50275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M621_RS50280	COG2252	PERMEase
M621_RS50290	COG0431	NADPH-dependent FMN reductase
M621_RS50295	COG2091	lysine biosynthetic process via aminoadipic acid
M621_RS50305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M621_RS50310	COG0706	membrane insertase activity
M621_RS50315	COG0594	ribonuclease P activity