locus-tag	class	description
CWC46_RS00015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CWC46_RS00025	COG2814	Major facilitator Superfamily
CWC46_RS00045	COG3550	peptidyl-serine autophosphorylation
CWC46_RS00110	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CWC46_RS00115	COG0732	type I restriction modification DNA specificity domain
CWC46_RS00125	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CWC46_RS00140	COG0582	viral genome integration into host DNA
CWC46_RS00150	COG0795	lipopolysaccharide-transporting ATPase activity
CWC46_RS00155	COG0795	lipopolysaccharide-transporting ATPase activity
CWC46_RS00160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWC46_RS00165	COG2927	DNA polymerase III (CHI subunit)
CWC46_RS00170	COG0525	valine-tRNA ligase activity
CWC46_RS00175	COG0656	L-ascorbic acid biosynthetic process
CWC46_RS00185	COG1397	ADP-ribosylglycohydrolase
CWC46_RS00195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC46_RS00215	COG2271	Major facilitator Superfamily
CWC46_RS00225	COG2132	Multicopper oxidase
CWC46_RS00230	COG0204	Acyl-transferase
CWC46_RS00235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWC46_RS00240	COG3711	transcriptional antiterminator
CWC46_RS00245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS00245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWC46_RS00245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWC46_RS00250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWC46_RS00255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWC46_RS00255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWC46_RS00270	COG2249	NAD(P)H dehydrogenase (quinone) activity
CWC46_RS00275	COG0583	DNA-binding transcription factor activity
CWC46_RS00280	COG0187	DNA topoisomerase II activity
CWC46_RS00285	COG3150	esterase
CWC46_RS00290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CWC46_RS00295	COG3151	Protein conserved in bacteria
CWC46_RS00300	COG0494	nUDIX hydrolase
CWC46_RS00305	COG1538	Outer membrane efflux protein
CWC46_RS00310	COG5463	Belongs to the UPF0441 family
CWC46_RS00315	COG0754	glutathionylspermidine amidase activity
CWC46_RS00320	COG3384	dioxygenase
CWC46_RS00330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CWC46_RS00335	COG3107	peptidoglycan biosynthetic process
CWC46_RS00340	COG0792	nuclease activity
CWC46_RS00345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CWC46_RS00350	COG2823	Periplasmic or secreted lipoprotein
CWC46_RS00360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWC46_RS00365	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CWC46_RS00370	COG2198	Histidine kinase
CWC46_RS00370	COG5002	protein histidine kinase activity
CWC46_RS00370	COG0784	Response regulator, receiver
CWC46_RS00375	COG1242	4 iron, 4 sulfur cluster binding
CWC46_RS00380	COG0067	glutamate synthase
CWC46_RS00380	COG0070	glutamate synthase
CWC46_RS00380	COG0069	glutamate synthase activity
CWC46_RS00385	COG0493	'glutamate synthase
CWC46_RS00395	COG2969	positive regulation of protein catabolic process
CWC46_RS00400	COG0625	glutathione transferase activity
CWC46_RS00405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWC46_RS00420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CWC46_RS00425	COG3105	Protein conserved in bacteria
CWC46_RS00430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWC46_RS00435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWC46_RS00440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWC46_RS00445	COG5007	Belongs to the BolA IbaG family
CWC46_RS00450	COG3113	response to antibiotic
CWC46_RS00455	COG2854	intermembrane phospholipid transfer
CWC46_RS00460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CWC46_RS00465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CWC46_RS00470	COG1127	ABC transporter
CWC46_RS00475	COG0530	calcium, potassium:sodium antiporter activity
CWC46_RS00480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CWC46_RS00480	COG0517	IMP dehydrogenase activity
CWC46_RS00485	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CWC46_RS00490	COG3117	lipopolysaccharide transmembrane transporter activity
CWC46_RS00495	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CWC46_RS00500	COG1137	ATPase activity
CWC46_RS00505	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CWC46_RS00525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS00530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWC46_RS00535	COG0312	modulator of DNA gyrase
CWC46_RS00540	COG3028	Belongs to the UPF0307 family
CWC46_RS00545	COG0180	Tryptophanyl-tRNA synthetase
CWC46_RS00550	COG0546	phosphoglycolate phosphatase activity
CWC46_RS00555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWC46_RS00565	COG3266	domain, Protein
CWC46_RS00570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWC46_RS00575	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWC46_RS00585	COG4796	Type ii and iii secretion system protein
CWC46_RS00610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CWC46_RS00615	COG0494	nUDIX hydrolase
CWC46_RS00625	COG1011	Hydrolase
CWC46_RS00630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CWC46_RS00635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CWC46_RS00640	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CWC46_RS00650	COG0745	RESPONSE REGULATOR receiver
CWC46_RS00655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWC46_RS00670	COG2183	response to ionizing radiation
CWC46_RS00675	COG2267	carboxylic ester hydrolase activity
CWC46_RS00680	COG1040	competence protein
CWC46_RS00685	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CWC46_RS00685	COG0316	Belongs to the HesB IscA family
CWC46_RS00690	COG1640	4-alpha-glucanotransferase
CWC46_RS00695	COG0058	SHG alpha-glucan phosphorylase activity
CWC46_RS00700	COG1349	DNA-binding transcription factor activity
CWC46_RS00705	COG0705	Rhomboid family
CWC46_RS00710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC46_RS00715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWC46_RS00740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS00755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CWC46_RS00760	COG1289	transmembrane transporter activity
CWC46_RS00765	COG1566	PFAM secretion protein HlyD family protein
CWC46_RS00775	COG0583	DNA-binding transcription factor activity
CWC46_RS00780	COG0312	modulator of DNA gyrase
CWC46_RS00785	COG3164	Protein of unknown function
CWC46_RS00790	COG1530	ribonuclease E activity
CWC46_RS00795	COG0424	maF-like protein
CWC46_RS00800	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CWC46_RS00805	COG1792	Involved in formation and maintenance of cell shape
CWC46_RS00810	COG1077	Cell shape determining protein MreB Mrl
CWC46_RS00815	COG2199	diguanylate cyclase activity
CWC46_RS00815	COG2200	EAL domain
CWC46_RS00820	COG0604	alcohol dehydrogenase
CWC46_RS00825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CWC46_RS00830	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CWC46_RS00835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CWC46_RS00840	COG0511	ligase activity, forming carbon-carbon bonds
CWC46_RS00845	COG0439	Biotin carboxylase
CWC46_RS00850	COG3924	membrane
CWC46_RS00855	COG4145	pantothenate transmembrane transporter activity
CWC46_RS00860	COG2264	protein methyltransferase activity
CWC46_RS00870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CWC46_RS00880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS00885	COG0765	amino acid transport
CWC46_RS00890	COG0504	CTP synthase activity
CWC46_RS00895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS00900	COG4597	amino acid ABC transporter
CWC46_RS00905	COG0765	amino acid transport
CWC46_RS00910	COG1126	abc transporter atp-binding protein
CWC46_RS00950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWC46_RS00955	COG1739	Uncharacterized protein family UPF0029
CWC46_RS00960	COG0006	proline dipeptidase activity
CWC46_RS00965	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWC46_RS00965	COG1024	Enoyl-CoA hydratase
CWC46_RS00970	COG0183	Belongs to the thiolase family
CWC46_RS00980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CWC46_RS00995	COG0084	hydrolase, TatD family'
CWC46_RS01000	COG0805	protein transport
CWC46_RS01005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWC46_RS01010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWC46_RS01015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CWC46_RS01020	COG3165	ubiquinone biosynthetic process from chorismate
CWC46_RS01025	COG2226	methyltransferase
CWC46_RS01030	COG1322	Protein conserved in bacteria
CWC46_RS01045	COG0444	Belongs to the ABC transporter superfamily
CWC46_RS01055	COG0601	transmembrane transport
CWC46_RS01070	COG0583	DNA-binding transcription factor activity
CWC46_RS01075	COG1561	YicC-like family, N-terminal region
CWC46_RS01095	COG2856	Zn peptidase
CWC46_RS01105	COG3177	Filamentation induced by cAMP protein fic
CWC46_RS01140	COG3012	SEC-C Motif Domain Protein
CWC46_RS01165	COG0747	negative chemotaxis
CWC46_RS01170	COG0601	transmembrane transport
CWC46_RS01175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS01220	COG2204	response regulator
CWC46_RS01255	COG0003	Pfam Anion-transporting ATPase
CWC46_RS01295	COG0736	holo-[acyl-carrier-protein] synthase activity
CWC46_RS01300	COG1136	(ABC) transporter
CWC46_RS01315	COG0137	argininosuccinate synthase activity
CWC46_RS01325	COG2207	Transcriptional regulator
CWC46_RS01325	COG1609	Transcriptional regulator
CWC46_RS01330	COG4214	carbohydrate transport
CWC46_RS01335	COG1129	ABC transporter
CWC46_RS01340	COG4213	ABC transporter substrate-binding protein
CWC46_RS01345	COG2115	Belongs to the xylose isomerase family
CWC46_RS01355	COG1070	Carbohydrate kinase
CWC46_RS01370	COG3274	enterobacterial common antigen metabolic process
CWC46_RS01375	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS01380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CWC46_RS01385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CWC46_RS01395	COG0840	transmembrane signaling receptor activity
CWC46_RS01405	COG3722	fumarate hydratase activity
CWC46_RS01410	COG0246	Mannitol dehydrogenase
CWC46_RS01415	COG2213	PTS system mannitol-specific
CWC46_RS01415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS01435	COG3842	ATPase activity
CWC46_RS01455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC46_RS01475	COG2376	Dihydroxyacetone kinase
CWC46_RS01485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWC46_RS01500	COG0751	glycine-tRNA ligase activity
CWC46_RS01510	COG0730	response to heat
CWC46_RS01515	COG2818	Glycosylase
CWC46_RS01520	COG0456	acetyltransferase
CWC46_RS01525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWC46_RS01535	COG3977	Valine--pyruvate aminotransferase
CWC46_RS01565	COG1121	(ABC) transporter
CWC46_RS01585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWC46_RS01590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWC46_RS01595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWC46_RS01600	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CWC46_RS01610	COG4221	oxidoreductase activity
CWC46_RS01615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWC46_RS01620	COG0837	glucose binding
CWC46_RS01635	COG1609	Transcriptional regulator
CWC46_RS01640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS01665	COG3403	YqcI/YcgG family
CWC46_RS01670	COG1280	lysine exporter protein (LysE YggA)
CWC46_RS01675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWC46_RS01680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CWC46_RS01690	COG0742	ribosomal rna small subunit methyltransferase
CWC46_RS01695	COG1446	asparaginase
CWC46_RS01710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS01715	COG0601	transmembrane transport
CWC46_RS01720	COG0747	negative chemotaxis
CWC46_RS01725	COG4172	Belongs to the ABC transporter superfamily
CWC46_RS01730	COG4948	Mandelate Racemase Muconate Lactonizing
CWC46_RS01745	COG2149	membrane
CWC46_RS01750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CWC46_RS01755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CWC46_RS01760	COG1309	transcriptional regulator
CWC46_RS01765	COG0756	dUTP diphosphatase activity
CWC46_RS01770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWC46_RS01780	COG2003	Belongs to the UPF0758 family
CWC46_RS01785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWC46_RS01795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CWC46_RS01800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWC46_RS01810	COG1519	Transferase
CWC46_RS01815	COG0438	transferase activity, transferring glycosyl groups
CWC46_RS01820	COG0859	PFAM glycosyl transferase family 9
CWC46_RS01835	COG0859	PFAM glycosyl transferase family 9
CWC46_RS01840	COG0859	PFAM glycosyl transferase family 9
CWC46_RS01845	COG0859	PFAM glycosyl transferase family 9
CWC46_RS01850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWC46_RS01860	COG1063	alcohol dehydrogenase
CWC46_RS01865	COG2861	carbohydrate metabolic process
CWC46_RS01870	COG4942	peptidase
CWC46_RS01875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWC46_RS01880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CWC46_RS01885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWC46_RS01890	COG1045	serine acetyltransferase
CWC46_RS01900	COG0583	DNA-binding transcription factor activity
CWC46_RS01905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CWC46_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS01945	COG0523	cobalamin synthesis protein
CWC46_RS01955	COG0412	Dienelactone hydrolase
CWC46_RS01970	COG1966	Carbon starvation protein
CWC46_RS01975	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CWC46_RS01980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWC46_RS01985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CWC46_RS01990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWC46_RS01995	COG0165	Argininosuccinate lyase
CWC46_RS02000	COG0589	response to stress
CWC46_RS02010	COG0306	phosphate transporter
CWC46_RS02015	COG2081	HI0933 family
CWC46_RS02075	COG2814	Major facilitator Superfamily
CWC46_RS02100	COG4221	oxidoreductase activity
CWC46_RS02115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWC46_RS02120	COG0194	GDP metabolic process
CWC46_RS02125	COG1758	RNA polymerase activity
CWC46_RS02130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWC46_RS02135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWC46_RS02140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CWC46_RS02145	COG2233	PERMEase
CWC46_RS02150	COG2982	Protein involved in outer membrane biogenesis
CWC46_RS02155	COG0456	acetyltransferase
CWC46_RS02160	COG1490	D-aminoacyl-tRNA deacylase activity
CWC46_RS02165	COG1011	Hydrolase
CWC46_RS02175	COG0174	glutamine synthetase
CWC46_RS02180	COG3852	Histidine kinase
CWC46_RS02195	COG3078	GTPase activator activity
CWC46_RS02200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CWC46_RS02205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWC46_RS02205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWC46_RS02215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CWC46_RS02220	COG3084	Protein conserved in bacteria
CWC46_RS02225	COG0746	molybdenum cofactor guanylyltransferase activity
CWC46_RS02230	COG1763	Mo-molybdopterin cofactor biosynthetic process
CWC46_RS02260	COG0151	Belongs to the GarS family
CWC46_RS02280	COG1515	deoxyribonuclease V activity
CWC46_RS02285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWC46_RS02290	COG2816	NAD+ diphosphatase activity
CWC46_RS02295	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CWC46_RS02300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CWC46_RS02305	COG0352	thiamine-phosphate diphosphorylase activity
CWC46_RS02310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWC46_RS02315	COG2104	thiamine diphosphate biosynthetic process
CWC46_RS02320	COG2022	thiamine diphosphate biosynthetic process
CWC46_RS02325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWC46_RS02330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWC46_RS02345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWC46_RS02350	COG0085	RNA polymerase activity
CWC46_RS02355	COG0222	ribosome binding
CWC46_RS02360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWC46_RS02375	COG0250	Participates in transcription elongation, termination and antitermination
CWC46_RS02385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWC46_RS02415	COG1072	(Pantothenic acid kinase))
CWC46_RS02420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CWC46_RS02420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CWC46_RS02425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWC46_RS02450	COG1609	Transcriptional regulator
CWC46_RS02455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC46_RS02465	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS02470	COG1129	ABC transporter
CWC46_RS02475	COG1869	D-ribose catabolic process
CWC46_RS02480	COG3158	transport of potassium into the cell
CWC46_RS02485	COG0714	Associated with various cellular activities
CWC46_RS02490	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CWC46_RS02495	COG1522	sequence-specific DNA binding
CWC46_RS02500	COG0716	FMN binding
CWC46_RS02505	COG0445	tRNA wobble uridine modification
CWC46_RS02510	COG0357	Ribosomal RNA small subunit methyltransferase G
CWC46_RS02515	COG3312	ion transport
CWC46_RS02520	COG0356	it plays a direct role in the translocation of protons across the membrane
CWC46_RS02530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWC46_RS02535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWC46_RS02540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWC46_RS02545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWC46_RS02550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWC46_RS02555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWC46_RS02565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWC46_RS02570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWC46_RS02615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWC46_RS02625	COG0318	PFAM AMP-dependent synthetase and ligase
CWC46_RS02630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWC46_RS02660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWC46_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS02675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWC46_RS02680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CWC46_RS02685	COG0573	inorganic phosphate transmembrane transporter activity
CWC46_RS02690	COG0581	inorganic phosphate transmembrane transporter activity
CWC46_RS02695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWC46_RS02705	COG1309	transcriptional regulator
CWC46_RS02730	COG0747	negative chemotaxis
CWC46_RS02745	COG0444	Belongs to the ABC transporter superfamily
CWC46_RS02750	COG4608	Belongs to the ABC transporter superfamily
CWC46_RS02770	COG1522	sequence-specific DNA binding
CWC46_RS02775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWC46_RS02780	COG2252	PERMEase
CWC46_RS02785	COG2091	lysine biosynthetic process via aminoadipic acid
CWC46_RS02795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWC46_RS02795	COG0493	'glutamate synthase
CWC46_RS02815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWC46_RS02820	COG0463	Glycosyl transferase, family 2
CWC46_RS02830	COG0726	polysaccharide deacetylase
CWC46_RS02835	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CWC46_RS02840	COG2076	Multidrug Resistance protein
CWC46_RS02845	COG2076	Multidrug Resistance protein
CWC46_RS02855	COG0444	Belongs to the ABC transporter superfamily
CWC46_RS02860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS02865	COG0601	transmembrane transport
CWC46_RS02870	COG0747	negative chemotaxis
CWC46_RS02875	COG1595	DNA-templated transcription, initiation
CWC46_RS02880	COG0701	Predicted permease
CWC46_RS02895	COG1595	DNA-templated transcription, initiation
CWC46_RS02900	COG1396	sequence-specific DNA binding
CWC46_RS02910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWC46_RS02915	COG0706	membrane insertase activity
CWC46_RS02925	COG0594	ribonuclease P activity
CWC46_RS02930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CWC46_RS02940	COG0592	DNA-directed DNA polymerase activity
CWC46_RS02945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWC46_RS02960	COG0840	transmembrane signaling receptor activity
CWC46_RS02965	COG0561	phosphatase activity
CWC46_RS02985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWC46_RS02990	COG2723	6-phospho-beta-galactosidase activity
CWC46_RS02995	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWC46_RS03015	COG1069	ribulokinase activity
CWC46_RS03025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWC46_RS03055	COG5645	(Lipo)protein
CWC46_RS03060	COG0071	Belongs to the small heat shock protein (HSP20) family
CWC46_RS03065	COG0071	Belongs to the small heat shock protein (HSP20) family
CWC46_RS03070	COG2985	domain, Protein
CWC46_RS03070	COG0569	domain protein
CWC46_RS03075	COG3290	protein histidine kinase activity
CWC46_RS03080	COG4565	transcriptional regulatory protein
CWC46_RS03085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWC46_RS03090	COG3730	PTS system glucitol sorbitol-specific
CWC46_RS03105	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS03110	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS03115	COG1349	DNA-binding transcription factor activity
CWC46_RS03125	COG3493	citrate carrier protein
CWC46_RS03135	COG0747	negative chemotaxis
CWC46_RS03140	COG0601	transmembrane transport
CWC46_RS03145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS03150	COG0444	Belongs to the ABC transporter superfamily
CWC46_RS03155	COG4608	Belongs to the ABC transporter superfamily
CWC46_RS03170	COG2894	cell division
CWC46_RS03185	COG0457	Tetratricopeptide repeat
CWC46_RS03195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CWC46_RS03205	COG1301	dicarboxylic acid transport
CWC46_RS03210	COG0612	Peptidase, M16
CWC46_RS03215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC46_RS03220	COG1942	4-Oxalocrotonate Tautomerase
CWC46_RS03225	COG1295	ribonuclease BN
CWC46_RS03230	COG0477	Major facilitator Superfamily
CWC46_RS03240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CWC46_RS03245	COG0425	Belongs to the sulfur carrier protein TusA family
CWC46_RS03250	COG2217	Heavy metal translocating P-type atpase
CWC46_RS03255	COG3714	YhhN family
CWC46_RS03265	COG3776	membrane
CWC46_RS03270	COG0742	ribosomal rna small subunit methyltransferase
CWC46_RS03275	COG0552	protein localization to endoplasmic reticulum
CWC46_RS03275	COG0552	protein localization to endoplasmic reticulum
CWC46_RS03280	COG2884	Cell division ATP-binding protein ftsE
CWC46_RS03285	COG2177	Part of the ABC transporter FtsEX involved in
CWC46_RS03295	COG0456	acetyltransferase
CWC46_RS03300	COG0683	leucine binding
CWC46_RS03305	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS03310	COG4177	L-phenylalanine transmembrane transporter activity
CWC46_RS03315	COG0411	ABC transporter
CWC46_RS03320	COG0410	ABC transporter
CWC46_RS03325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWC46_RS03330	COG0840	transmembrane signaling receptor activity
CWC46_RS03335	COG2610	gluconate transmembrane transporter activity
CWC46_RS03340	COG3622	Belongs to the hyi family
CWC46_RS03345	COG0235	Class ii aldolase
CWC46_RS03350	COG3395	kinase activity
CWC46_RS03355	COG2084	Dehydrogenase
CWC46_RS03360	COG1349	DNA-binding transcription factor activity
CWC46_RS03365	COG1653	transport
CWC46_RS03370	COG1175	transmembrane transport
CWC46_RS03375	COG0395	ABC-type sugar transport system, permease component
CWC46_RS03380	COG3842	ATPase activity
CWC46_RS03385	COG0584	glycerophosphoryl diester phosphodiesterase
CWC46_RS03390	COG0679	Auxin Efflux Carrier
CWC46_RS03400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CWC46_RS03415	COG2205	protein histidine kinase activity
CWC46_RS03420	COG0745	RESPONSE REGULATOR receiver
CWC46_RS03425	COG3678	ATP-independent chaperone mediated protein folding
CWC46_RS03430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS03435	COG0765	amino acid transport
CWC46_RS03440	COG0765	amino acid transport
CWC46_RS03450	COG0436	Aminotransferase
CWC46_RS03460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWC46_RS03470	COG0494	nUDIX hydrolase
CWC46_RS03480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWC46_RS03485	COG0205	6-phosphofructokinase activity
CWC46_RS03490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWC46_RS03495	COG2957	Belongs to the agmatine deiminase family
CWC46_RS03500	COG0149	triose-phosphate isomerase activity
CWC46_RS03510	COG3152	Membrane
CWC46_RS03520	COG1494	fructose-1,6-bisphosphatase
CWC46_RS03525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWC46_RS03530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWC46_RS03535	COG3074	FtsZ-dependent cytokinesis
CWC46_RS03540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CWC46_RS03545	COG1575	Belongs to the MenA family. Type 1 subfamily
CWC46_RS03550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CWC46_RS03555	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CWC46_RS03560	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CWC46_RS03565	COG1609	Transcriptional regulator
CWC46_RS03570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWC46_RS03575	COG0254	rRNA binding
CWC46_RS03580	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CWC46_RS03585	COG0626	cystathionine gamma-synthase activity
CWC46_RS03590	COG0460	homoserine dehydrogenase
CWC46_RS03590	COG0527	aspartate kinase activity
CWC46_RS03610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWC46_RS03615	COG1309	transcriptional regulator
CWC46_RS03625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWC46_RS03630	COG4206	TonB-dependent receptor
CWC46_RS03635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWC46_RS03680	COG1879	ABC-type sugar transport system periplasmic component
CWC46_RS03685	COG1129	ABC transporter
CWC46_RS03690	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS03695	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS03700	COG0583	DNA-binding transcription factor activity
CWC46_RS03715	COG2814	Major facilitator Superfamily
CWC46_RS03730	COG3978	acetolactate synthase activity
CWC46_RS03740	COG0129	dihydroxy-acid dehydratase activity
CWC46_RS03745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWC46_RS03760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWC46_RS03765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWC46_RS03770	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CWC46_RS03770	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CWC46_RS03770	COG0506	proline dehydrogenase activity
CWC46_RS03775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWC46_RS03790	COG0248	Ppx GppA phosphatase
CWC46_RS03800	COG3118	belongs to the thioredoxin family
CWC46_RS03805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CWC46_RS03810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWC46_RS03820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CWC46_RS03825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CWC46_RS03830	COG0456	acetyltransferase
CWC46_RS03835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWC46_RS03840	COG2244	polysaccharide biosynthetic process
CWC46_RS03845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWC46_RS03855	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CWC46_RS03880	COG0402	S-adenosylhomocysteine deaminase activity
CWC46_RS03885	COG1116	anion transmembrane transporter activity
CWC46_RS03890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWC46_RS03895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWC46_RS03920	COG0494	nUDIX hydrolase
CWC46_RS03925	COG2814	Major facilitator Superfamily
CWC46_RS03935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CWC46_RS03935	COG2755	lipolytic protein G-D-S-L family
CWC46_RS03950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWC46_RS03955	COG1940	carbohydrate kinase activity
CWC46_RS03960	COG1063	alcohol dehydrogenase
CWC46_RS03970	COG1082	Xylose isomerase domain protein TIM barrel
CWC46_RS03975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWC46_RS04000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWC46_RS04020	COG1063	alcohol dehydrogenase
CWC46_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS04030	COG2610	gluconate transmembrane transporter activity
CWC46_RS04035	COG1609	Transcriptional regulator
CWC46_RS04040	COG3265	gluconokinase activity
CWC46_RS04045	COG0129	dihydroxy-acid dehydratase activity
CWC46_RS04050	COG3071	HemY protein
CWC46_RS04055	COG2959	enzyme of heme biosynthesis
CWC46_RS04060	COG1587	Uroporphyrinogen-III synthase
CWC46_RS04075	COG1965	Belongs to the frataxin family
CWC46_RS04080	COG5567	small periplasmic lipoprotein
CWC46_RS04085	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWC46_RS04095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CWC46_RS04100	COG1011	Hydrolase
CWC46_RS04105	COG0210	DNA helicase
CWC46_RS04110	COG0598	Magnesium transport protein CorA
CWC46_RS04115	COG3180	Ammonia monooxygenase
CWC46_RS04125	COG2050	protein possibly involved in aromatic compounds catabolism
CWC46_RS04135	COG0514	ATP-dependent DNA helicase (RecQ)
CWC46_RS04140	COG1280	lysine exporter protein (LysE YggA)
CWC46_RS04145	COG2267	carboxylic ester hydrolase activity
CWC46_RS04150	COG0561	phosphatase activity
CWC46_RS04155	COG2271	Major facilitator Superfamily
CWC46_RS04160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CWC46_RS04165	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CWC46_RS04170	COG0247	lactate metabolic process
CWC46_RS04180	COG1741	Belongs to the pirin family
CWC46_RS04185	COG1609	Transcriptional regulator
CWC46_RS04190	COG3265	gluconokinase activity
CWC46_RS04195	COG2610	gluconate transmembrane transporter activity
CWC46_RS04200	COG2095	MarC family integral membrane protein
CWC46_RS04205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWC46_RS04215	COG0864	Transcriptional regulator
CWC46_RS04220	COG2226	methyltransferase
CWC46_RS04220	COG1073	alpha beta
CWC46_RS04225	COG0747	negative chemotaxis
CWC46_RS04230	COG0601	transmembrane transport
CWC46_RS04240	COG0667	Aldo Keto reductase
CWC46_RS04280	COG3275	phosphorelay sensor kinase activity
CWC46_RS04295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CWC46_RS04300	COG0297	glycogen (starch) synthase activity
CWC46_RS04305	COG0058	SHG alpha-glucan phosphorylase activity
CWC46_RS04310	COG4948	Mandelate Racemase Muconate Lactonizing
CWC46_RS04315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CWC46_RS04320	COG3706	GGDEF domain
CWC46_RS04350	COG0583	DNA-binding transcription factor activity
CWC46_RS04355	COG0625	glutathione transferase activity
CWC46_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS04470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWC46_RS04475	COG1765	OsmC-like protein
CWC46_RS04485	COG0165	Argininosuccinate lyase
CWC46_RS04490	COG0765	amino acid transport
CWC46_RS04500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS04515	COG2079	MmgE PrpD family protein
CWC46_RS04520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWC46_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS04535	COG3724	N-succinylarginine dihydrolase activity
CWC46_RS04540	COG2988	succinylglutamate desuccinylase activity
CWC46_RS04545	COG3954	Phosphoribulokinase
CWC46_RS04555	COG0429	hydrolase of the alpha beta-hydrolase fold
CWC46_RS04565	COG0488	(ABC) transporter
CWC46_RS04570	COG2249	NAD(P)H dehydrogenase (quinone) activity
CWC46_RS04575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CWC46_RS04575	COG0475	glutathione-regulated potassium exporter activity
CWC46_RS04580	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CWC46_RS04585	COG1047	Peptidyl-prolyl cis-trans
CWC46_RS04605	COG2900	Belongs to the SlyX family
CWC46_RS04610	COG0545	Peptidyl-prolyl cis-trans isomerase
CWC46_RS04625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWC46_RS04645	COG0642	Histidine kinase
CWC46_RS04650	COG0745	RESPONSE REGULATOR receiver
CWC46_RS04655	COG2194	sulfuric ester hydrolase activity
CWC46_RS04660	COG2964	Protein conserved in bacteria
CWC46_RS04665	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CWC46_RS04670	COG2923	Belongs to the DsrF TusC family
CWC46_RS04680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWC46_RS04685	COG0049	tRNA binding
CWC46_RS04690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWC46_RS04695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWC46_RS04705	COG0051	transcription antitermination factor activity, RNA binding
CWC46_RS04710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWC46_RS04715	COG0088	Forms part of the polypeptide exit tunnel
CWC46_RS04720	COG0089	rRNA binding
CWC46_RS04730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CWC46_RS04735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWC46_RS04740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWC46_RS04745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWC46_RS04755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWC46_RS04765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWC46_RS04770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWC46_RS04775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWC46_RS04785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWC46_RS04790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWC46_RS04800	COG1841	ribosomal large subunit assembly
CWC46_RS04805	COG0200	Binds to the 23S rRNA
CWC46_RS04810	COG0201	protein transport
CWC46_RS04815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWC46_RS04820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWC46_RS04830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWC46_RS04840	COG0203	ribosomal protein L17
CWC46_RS04850	COG3036	rescue of stalled ribosome
CWC46_RS04855	COG1970	mechanosensitive ion channel activity
CWC46_RS04865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWC46_RS04865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWC46_RS04870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWC46_RS04875	COG0242	peptide deformylase activity
CWC46_RS04880	COG0758	DNA mediated transformation
CWC46_RS04885	COG2922	Belongs to the Smg family
CWC46_RS04890	COG0551	DNA topoisomerase type I activity
CWC46_RS04900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWC46_RS04905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CWC46_RS04935	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CWC46_RS04940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CWC46_RS04950	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CWC46_RS04965	COG0471	metal ion transport
CWC46_RS04970	COG1283	sodium-dependent phosphate transmembrane transporter activity
CWC46_RS04975	COG1979	alcohol dehydrogenase
CWC46_RS04980	COG2207	Transcriptional regulator
CWC46_RS04990	COG0626	cystathionine gamma-synthase activity
CWC46_RS05005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWC46_RS05015	COG0848	biopolymer transport protein
CWC46_RS05050	COG1203	CRISPR-associated helicase, Cas3
CWC46_RS05065	COG1857	crispr-associated protein
CWC46_RS05080	COG1518	maintenance of DNA repeat elements
CWC46_RS05085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWC46_RS05090	COG3787	Belongs to the UPF0306 family
CWC46_RS05095	COG0702	epimerase
CWC46_RS05100	COG0602	queuosine metabolic process
CWC46_RS05105	COG1328	CTP reductase activity
CWC46_RS05130	COG4172	Belongs to the ABC transporter superfamily
CWC46_RS05150	COG2308	Evidence 4 Homologs of previously reported genes of
CWC46_RS05160	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CWC46_RS05165	COG0540	Belongs to the ATCase OTCase family
CWC46_RS05170	COG2731	YhcH YjgK YiaL family protein
CWC46_RS05175	COG2190	(PTS) system
CWC46_RS05175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWC46_RS05175	COG1263	PTS System
CWC46_RS05180	COG2723	6-phospho-beta-galactosidase activity
CWC46_RS05185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CWC46_RS05205	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CWC46_RS05210	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CWC46_RS05215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWC46_RS05220	COG1053	succinate dehydrogenase
CWC46_RS05230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CWC46_RS05235	COG3264	Mechanosensitive ion channel
CWC46_RS05235	COG1511	domain protein
CWC46_RS05240	COG0688	phosphatidylethanolamine metabolic process
CWC46_RS05245	COG1162	GTPase activity
CWC46_RS05250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CWC46_RS05260	COG2271	Major facilitator Superfamily
CWC46_RS05265	COG1802	Transcriptional regulator
CWC46_RS05270	COG1063	alcohol dehydrogenase
CWC46_RS05280	COG2822	iron ion transport
CWC46_RS05285	COG2837	iron assimilation
CWC46_RS05300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC46_RS05305	COG2222	sugar isomerase
CWC46_RS05310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS05315	COG2188	Transcriptional regulator
CWC46_RS05395	COG1621	beta-fructofuranosidase activity
CWC46_RS05410	COG2205	protein histidine kinase activity
CWC46_RS05415	COG3604	Transcriptional regulator
CWC46_RS05430	COG0583	DNA-binding transcription factor activity
CWC46_RS05440	COG1473	amidohydrolase
CWC46_RS05445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CWC46_RS05450	COG1846	Transcriptional regulator
CWC46_RS05455	COG1764	response to oxidative stress
CWC46_RS05490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC46_RS05500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC46_RS05510	COG1136	(ABC) transporter
CWC46_RS05510	COG0577	efflux transmembrane transporter activity
CWC46_RS05515	COG1136	(ABC) transporter
CWC46_RS05530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWC46_RS05535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CWC46_RS05535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CWC46_RS05540	COG0802	atpase or kinase
CWC46_RS05545	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWC46_RS05550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CWC46_RS05555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWC46_RS05565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWC46_RS05570	COG0330	HflC and HflK could
CWC46_RS05575	COG0330	HflC and HflK could
CWC46_RS05580	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CWC46_RS05585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWC46_RS05590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWC46_RS05595	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CWC46_RS05600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWC46_RS05605	COG1509	lysine 2,3-aminomutase activity
CWC46_RS05615	COG0166	Belongs to the GPI family
CWC46_RS05620	COG0527	aspartate kinase activity
CWC46_RS05630	COG1678	Uncharacterized ACR, COG1678
CWC46_RS05635	COG0189	ligase activity
CWC46_RS05640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWC46_RS05645	COG2356	endonuclease I
CWC46_RS05650	COG3091	SprT-like family
CWC46_RS05655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWC46_RS05665	COG1166	arginine decarboxylase activity
CWC46_RS05670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CWC46_RS05675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWC46_RS05680	COG0126	phosphoglycerate kinase activity
CWC46_RS05690	COG0668	transmembrane transport
CWC46_RS05705	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS05710	COG1129	ABC transporter
CWC46_RS05715	COG1414	Transcriptional regulator
CWC46_RS05720	COG1279	arginine transmembrane transporter activity
CWC46_RS05730	COG0583	DNA-binding transcription factor activity
CWC46_RS05735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CWC46_RS05740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC46_RS05745	COG0840	transmembrane signaling receptor activity
CWC46_RS05750	COG0488	(ABC) transporter
CWC46_RS05760	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CWC46_RS05765	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CWC46_RS05775	COG2207	Transcriptional regulator
CWC46_RS05775	COG3708	Transcriptional regulator
CWC46_RS05780	COG3045	CreA protein
CWC46_RS05785	COG0745	RESPONSE REGULATOR receiver
CWC46_RS05790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CWC46_RS05800	COG0083	homoserine kinase activity
CWC46_RS05810	COG3022	response to hydroperoxide
CWC46_RS05815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWC46_RS05820	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWC46_RS05825	COG0477	Major facilitator Superfamily
CWC46_RS05835	COG1584	GPR1 FUN34 yaaH family protein
CWC46_RS05840	COG0443	Heat shock 70 kDa protein
CWC46_RS05845	COG0484	heat shock protein binding
CWC46_RS05850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CWC46_RS05855	COG0583	DNA-binding transcription factor activity
CWC46_RS05860	COG0268	Binds directly to 16S ribosomal RNA
CWC46_RS05870	COG0196	riboflavin kinase activity
CWC46_RS05875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CWC46_RS05880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWC46_RS05885	COG1047	Peptidyl-prolyl cis-trans
CWC46_RS05890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWC46_RS05900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWC46_RS05910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWC46_RS05915	COG1280	lysine exporter protein (LysE YggA)
CWC46_RS05920	COG2966	Psort location CytoplasmicMembrane, score
CWC46_RS05925	COG3610	response to peptide
CWC46_RS05930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CWC46_RS05940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CWC46_RS05945	COG2967	ApaG domain
CWC46_RS05950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWC46_RS05955	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CWC46_RS05960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWC46_RS05965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CWC46_RS05970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CWC46_RS05975	COG0564	pseudouridine synthase activity
CWC46_RS05980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWC46_RS05985	COG0417	DNA replication proofreading
CWC46_RS06015	COG0586	Pfam SNARE associated Golgi protein
CWC46_RS06020	COG0440	acetolactate synthase activity
CWC46_RS06025	COG0028	Belongs to the TPP enzyme family
CWC46_RS06035	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CWC46_RS06050	COG4533	DNA binding
CWC46_RS06060	COG3033	Beta-eliminating lyase
CWC46_RS06070	COG0066	3-isopropylmalate dehydratase activity
CWC46_RS06075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWC46_RS06080	COG0473	3-isopropylmalate dehydrogenase activity
CWC46_RS06085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWC46_RS06090	COG1022	Amp-dependent synthetase and ligase
CWC46_RS06095	COG0028	Belongs to the TPP enzyme family
CWC46_RS06115	COG2001	Belongs to the MraZ family
CWC46_RS06120	COG0275	rRNA processing
CWC46_RS06125	COG3116	cell division
CWC46_RS06130	COG0768	penicillin binding
CWC46_RS06135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWC46_RS06140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWC46_RS06145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWC46_RS06150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWC46_RS06155	COG0772	Belongs to the SEDS family
CWC46_RS06160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWC46_RS06165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWC46_RS06170	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWC46_RS06175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CWC46_RS06180	COG0849	cell division
CWC46_RS06185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWC46_RS06190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CWC46_RS06205	COG0653	protein targeting
CWC46_RS06210	COG0494	nUDIX hydrolase
CWC46_RS06215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CWC46_RS06220	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CWC46_RS06225	COG0237	dephospho-CoA kinase activity
CWC46_RS06230	COG0516	GMP reductase activity
CWC46_RS06235	COG1459	type II secretion system
CWC46_RS06240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWC46_RS06245	COG4969	Belongs to the N-Me-Phe pilin family
CWC46_RS06255	COG3023	N-Acetylmuramoyl-L-alanine amidase
CWC46_RS06260	COG3725	Membrane protein required for beta-lactamase induction
CWC46_RS06265	COG3940	Belongs to the glycosyl hydrolase 43 family
CWC46_RS06270	COG2211	Major facilitator Superfamily
CWC46_RS06275	COG1113	amino acid transport
CWC46_RS06285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CWC46_RS06290	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWC46_RS06295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWC46_RS06300	COG1073	alpha beta
CWC46_RS06310	COG3112	Uncharacterised protein family (UPF0231)
CWC46_RS06315	COG2271	Major facilitator Superfamily
CWC46_RS06320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC46_RS06325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWC46_RS06330	COG1454	alcohol dehydrogenase
CWC46_RS06335	COG3395	kinase activity
CWC46_RS06340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CWC46_RS06345	COG1349	DNA-binding transcription factor activity
CWC46_RS06355	COG1609	Transcriptional regulator
CWC46_RS06360	COG1940	carbohydrate kinase activity
CWC46_RS06370	COG1653	transport
CWC46_RS06375	COG1175	transmembrane transport
CWC46_RS06380	COG0395	ABC-type sugar transport system, permease component
CWC46_RS06385	COG3842	ATPase activity
CWC46_RS06390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWC46_RS06395	COG0129	dihydroxy-acid dehydratase activity
CWC46_RS06400	COG2610	gluconate transmembrane transporter activity
CWC46_RS06405	COG1414	Transcriptional regulator
CWC46_RS06415	COG0803	Belongs to the bacterial solute-binding protein 9 family
CWC46_RS06425	COG1121	(ABC) transporter
CWC46_RS06445	COG0297	glycogen (starch) synthase activity
CWC46_RS06445	COG0438	transferase activity, transferring glycosyl groups
CWC46_RS06450	COG0765	amino acid transport
CWC46_RS06455	COG0765	amino acid transport
CWC46_RS06470	COG4598	ABC transporter
CWC46_RS06475	COG1802	Transcriptional regulator
CWC46_RS06490	COG4208	sulfate ABC transporter
CWC46_RS06495	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CWC46_RS06530	COG0629	single-stranded DNA binding
CWC46_RS06545	COG0432	Pfam Uncharacterised protein family UPF0047
CWC46_RS06550	COG3706	GGDEF domain
CWC46_RS06580	COG1203	CRISPR-associated helicase, Cas3
CWC46_RS06585	COG1518	maintenance of DNA repeat elements
CWC46_RS06590	COG1448	Aminotransferase
CWC46_RS06600	COG1522	sequence-specific DNA binding
CWC46_RS06615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWC46_RS06625	COG0604	alcohol dehydrogenase
CWC46_RS06635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CWC46_RS06655	COG4221	oxidoreductase activity
CWC46_RS06675	COG2188	Transcriptional regulator
CWC46_RS06700	COG3842	ATPase activity
CWC46_RS06705	COG0583	DNA-binding transcription factor activity
CWC46_RS06715	COG0277	FAD linked oxidase domain protein
CWC46_RS06720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWC46_RS06740	COG0251	oxidation-reduction process
CWC46_RS06745	COG0402	S-adenosylhomocysteine deaminase activity
CWC46_RS06750	COG0583	DNA-binding transcription factor activity
CWC46_RS06775	COG3634	alkyl hydroperoxide reductase activity
CWC46_RS06825	COG2814	Major facilitator Superfamily
CWC46_RS06835	COG0019	diaminopimelate decarboxylase activity
CWC46_RS06855	COG4772	TonB-dependent receptor
CWC46_RS06865	COG0625	glutathione transferase activity
CWC46_RS06870	COG0625	glutathione transferase activity
CWC46_RS06875	COG1609	Transcriptional regulator
CWC46_RS06880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWC46_RS06885	COG2723	6-phospho-beta-galactosidase activity
CWC46_RS06890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWC46_RS06895	COG2186	Transcriptional regulator
CWC46_RS06900	COG1609	Transcriptional regulator
CWC46_RS06905	COG3344	reverse transcriptase
CWC46_RS06910	COG0204	Acyl-transferase
CWC46_RS06910	COG0318	PFAM AMP-dependent synthetase and ligase
CWC46_RS06915	COG0477	Major facilitator Superfamily
CWC46_RS06920	COG2153	protein acetylation
CWC46_RS06925	COG5510	response to toxic substance
CWC46_RS06930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWC46_RS06935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWC46_RS06940	COG1872	DUF167
CWC46_RS06945	COG0762	integral membrane protein
CWC46_RS06950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWC46_RS06955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CWC46_RS06960	COG2805	Type II/IV secretion system protein
CWC46_RS06965	COG0402	S-adenosylhomocysteine deaminase activity
CWC46_RS06975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CWC46_RS06985	COG1959	2 iron, 2 sulfur cluster binding
CWC46_RS06990	COG0557	exoribonuclease II activity
CWC46_RS06995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWC46_RS07010	COG0840	transmembrane signaling receptor activity
CWC46_RS07015	COG0360	Binds together with S18 to 16S ribosomal RNA
CWC46_RS07020	COG2965	DNA replication, synthesis of RNA primer
CWC46_RS07025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWC46_RS07030	COG0359	binds to the 23S rRNA
CWC46_RS07040	COG0545	Peptidyl-prolyl cis-trans isomerase
CWC46_RS07065	COG0410	ABC transporter
CWC46_RS07070	COG1137	ATPase activity
CWC46_RS07075	COG4177	L-phenylalanine transmembrane transporter activity
CWC46_RS07100	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CWC46_RS07110	COG1253	flavin adenine dinucleotide binding
CWC46_RS07115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWC46_RS07120	COG0729	surface antigen
CWC46_RS07130	COG2105	PFAM AIG2 family protein
CWC46_RS07135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CWC46_RS07140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CWC46_RS07145	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CWC46_RS07150	COG1968	undecaprenyl-diphosphatase activity
CWC46_RS07155	COG0617	tRNA 3'-terminal CCA addition
CWC46_RS07165	COG4991	sh3 domain protein
CWC46_RS07170	COG3025	triphosphatase activity
CWC46_RS07175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CWC46_RS07180	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CWC46_RS07180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWC46_RS07185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWC46_RS07190	COG3530	Putative quorum-sensing-regulated virulence factor
CWC46_RS07205	COG2721	sulfolactate sulfo-lyase activity
CWC46_RS07210	COG2271	Major facilitator Superfamily
CWC46_RS07215	COG4948	Mandelate Racemase Muconate Lactonizing
CWC46_RS07220	COG4948	Mandelate Racemase Muconate Lactonizing
CWC46_RS07230	COG2084	Dehydrogenase
CWC46_RS07235	COG1929	Belongs to the glycerate kinase type-1 family
CWC46_RS07245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWC46_RS07250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWC46_RS07255	COG3956	TIGRFAM MazG family protein
CWC46_RS07260	COG0504	CTP synthase activity
CWC46_RS07265	COG0148	phosphopyruvate hydratase activity
CWC46_RS07285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CWC46_RS07290	COG0602	queuosine metabolic process
CWC46_RS07295	COG0720	synthase
CWC46_RS07300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CWC46_RS07305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWC46_RS07310	COG0175	sulfate reduction
CWC46_RS07315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWC46_RS07315	COG1648	precorrin-2 dehydrogenase activity
CWC46_RS07320	COG0175	sulfate reduction
CWC46_RS07325	COG2895	sulfate adenylyltransferase (ATP) activity
CWC46_RS07330	COG0529	Catalyzes the synthesis of activated sulfate
CWC46_RS07340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CWC46_RS07345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CWC46_RS07350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWC46_RS07355	COG0585	pseudouridine synthase activity
CWC46_RS07360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CWC46_RS07375	COG0442	prolyl-tRNA aminoacylation
CWC46_RS07380	COG1720	tRNA m6t6A37 methyltransferase activity
CWC46_RS07390	COG1464	Belongs to the NlpA lipoprotein family
CWC46_RS07395	COG2011	ABC-type metal ion transport system permease component
CWC46_RS07400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWC46_RS07405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CWC46_RS07430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWC46_RS07435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWC46_RS07435	COG1042	CoA-binding domain protein
CWC46_RS07435	COG0045	succinate-CoA ligase (ADP-forming) activity
CWC46_RS07445	COG3118	belongs to the thioredoxin family
CWC46_RS07450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWC46_RS07455	COG2814	Major facilitator Superfamily
CWC46_RS07460	COG1566	PFAM secretion protein HlyD family protein
CWC46_RS07465	COG1846	Transcriptional regulator
CWC46_RS07475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWC46_RS07480	COG2814	Major facilitator Superfamily
CWC46_RS07485	COG2113	Glycine betaine
CWC46_RS07490	COG4176	ABC-type proline glycine betaine transport system permease component
CWC46_RS07495	COG4175	Glycine betaine
CWC46_RS07510	COG2226	methyltransferase
CWC46_RS07520	COG1953	Uracil, thiamine, allantoin
CWC46_RS07580	COG0765	amino acid transport
CWC46_RS07590	COG1126	abc transporter atp-binding protein
CWC46_RS07595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CWC46_RS07610	COG0436	Aminotransferase
CWC46_RS07620	COG1960	acyl-CoA dehydrogenase activity
CWC46_RS07625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CWC46_RS07630	COG0121	glutamine amidotransferase
CWC46_RS07635	COG3034	peptidoglycan biosynthetic process
CWC46_RS07640	COG1477	protein flavinylation
CWC46_RS07645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWC46_RS07650	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWC46_RS07655	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CWC46_RS07670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CWC46_RS07675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CWC46_RS07685	COG0582	viral genome integration into host DNA
CWC46_RS07710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWC46_RS07755	COG1484	DNA-dependent DNA replication
CWC46_RS07830	COG1783	phage Terminase large subunit
CWC46_RS07835	COG3567	Phage-associated protein, HI1409 family
CWC46_RS07960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CWC46_RS08010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CWC46_RS08030	COG1486	melibiose metabolic process
CWC46_RS08035	COG0583	DNA-binding transcription factor activity
CWC46_RS08065	COG0346	lactoylglutathione lyase activity
CWC46_RS08075	COG1349	DNA-binding transcription factor activity
CWC46_RS08080	COG1472	Belongs to the glycosyl hydrolase 3 family
CWC46_RS08085	COG2211	Major facilitator Superfamily
CWC46_RS08090	COG1914	H( )-stimulated, divalent metal cation uptake system
CWC46_RS08115	COG0601	transmembrane transport
CWC46_RS08120	COG0747	negative chemotaxis
CWC46_RS08125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWC46_RS08130	COG2188	Transcriptional regulator
CWC46_RS08135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWC46_RS08140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWC46_RS08150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWC46_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS08175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWC46_RS08180	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CWC46_RS08185	COG2986	histidine ammonia-lyase
CWC46_RS08215	COG0688	phosphatidylethanolamine metabolic process
CWC46_RS08230	COG0072	phenylalanine-tRNA ligase activity
CWC46_RS08230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWC46_RS08265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC46_RS08280	COG3038	cytochrome b561
CWC46_RS08290	COG1546	Belongs to the CinA family
CWC46_RS08295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CWC46_RS08300	COG2137	regulation of response to DNA damage stimulus
CWC46_RS08305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWC46_RS08310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CWC46_RS08335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWC46_RS08340	COG2918	glutathione biosynthetic process
CWC46_RS08345	COG1854	S-ribosylhomocysteine lyase activity
CWC46_RS08350	COG4137	Cytochrome C assembly protein
CWC46_RS08355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CWC46_RS08360	COG0228	four-way junction DNA binding
CWC46_RS08365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWC46_RS08370	COG0336	Belongs to the RNA methyltransferase TrmD family
CWC46_RS08385	COG3279	Response regulator of the LytR AlgR family
CWC46_RS08390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CWC46_RS08395	COG0287	Prephenate dehydrogenase
CWC46_RS08395	COG1605	Chorismate mutase
CWC46_RS08400	COG1605	Chorismate mutase
CWC46_RS08400	COG0077	Prephenate dehydratase
CWC46_RS08405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CWC46_RS08410	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWC46_RS08420	COG0564	pseudouridine synthase activity
CWC46_RS08430	COG0542	response to heat
CWC46_RS08470	COG0582	viral genome integration into host DNA
CWC46_RS08490	COG3021	interspecies interaction between organisms
CWC46_RS08500	COG0741	lytic transglycosylase activity
CWC46_RS08500	COG1388	LysM domain
CWC46_RS08505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWC46_RS08510	COG2226	methyltransferase
CWC46_RS08540	COG1335	isochorismatase
CWC46_RS08555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CWC46_RS08560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWC46_RS08585	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CWC46_RS08590	COG0288	reversible hydration of carbon dioxide
CWC46_RS08595	COG1131	(ABC) transporter
CWC46_RS08600	COG0842	Transport permease protein
CWC46_RS08605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CWC46_RS08610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWC46_RS08615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWC46_RS08620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CWC46_RS08625	COG0617	tRNA 3'-terminal CCA addition
CWC46_RS08630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWC46_RS08640	COG1489	DNA binding
CWC46_RS08645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CWC46_RS08650	COG1643	Atp-dependent helicase
CWC46_RS08655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWC46_RS08660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWC46_RS08670	COG0316	Belongs to the HesB IscA family
CWC46_RS08675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWC46_RS08680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWC46_RS08685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CWC46_RS08690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWC46_RS08695	COG3835	regulator
CWC46_RS08700	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CWC46_RS08710	COG4208	sulfate ABC transporter
CWC46_RS08715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CWC46_RS08730	COG2733	membrane
CWC46_RS08735	COG0395	ABC-type sugar transport system, permease component
CWC46_RS08740	COG1175	transmembrane transport
CWC46_RS08760	COG1940	carbohydrate kinase activity
CWC46_RS08765	COG2971	BadF BadG BcrA BcrD
CWC46_RS08775	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CWC46_RS08780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWC46_RS08795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWC46_RS08830	COG0513	Belongs to the DEAD box helicase family
CWC46_RS08835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWC46_RS08840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CWC46_RS08855	COG3026	antisigma factor binding
CWC46_RS08860	COG3086	response to oxidative stress
CWC46_RS08865	COG0481	GTPase activity
CWC46_RS08875	COG0571	ribonuclease III activity
CWC46_RS08880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWC46_RS08885	COG1381	Involved in DNA repair and RecF pathway recombination
CWC46_RS08890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CWC46_RS08900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWC46_RS08905	COG2200	EAL domain
CWC46_RS08920	COG2274	protein secretion by the type I secretion system
CWC46_RS08925	COG1538	Outer membrane efflux protein
CWC46_RS08940	COG2199	diguanylate cyclase activity
CWC46_RS08940	COG3287	FIST C domain
CWC46_RS08940	COG2200	EAL domain
CWC46_RS08950	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CWC46_RS08960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CWC46_RS08965	COG0047	phosphoribosylformylglycinamidine synthase activity
CWC46_RS08965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWC46_RS08970	COG2205	protein histidine kinase activity
CWC46_RS08975	COG3170	Tfp pilus assembly protein FimV
CWC46_RS08980	COG2204	response regulator
CWC46_RS08985	COG0347	Belongs to the P(II) protein family
CWC46_RS08990	COG4677	pectinesterase activity
CWC46_RS09005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWC46_RS09010	COG2814	Major facilitator Superfamily
CWC46_RS09015	COG3683	transport system, periplasmic component
CWC46_RS09020	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CWC46_RS09025	COG1120	ATPase activity
CWC46_RS09030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWC46_RS09040	COG0483	inositol monophosphate 1-phosphatase activity
CWC46_RS09045	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CWC46_RS09050	COG1959	2 iron, 2 sulfur cluster binding
CWC46_RS09060	COG0822	iron-sulfur transferase activity
CWC46_RS09065	COG0316	Belongs to the HesB IscA family
CWC46_RS09070	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CWC46_RS09075	COG0443	Heat shock 70 kDa protein
CWC46_RS09080	COG0633	Ferredoxin
CWC46_RS09085	COG2975	iron-sulfur cluster assembly
CWC46_RS09090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWC46_RS09100	COG2897	thiosulfate sulfurtransferase activity
CWC46_RS09105	COG0105	UTP biosynthetic process
CWC46_RS09110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWC46_RS09120	COG1426	Protein conserved in bacteria
CWC46_RS09125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CWC46_RS09130	COG0124	histidyl-tRNA synthetase
CWC46_RS09135	COG2976	Protein conserved in bacteria
CWC46_RS09140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWC46_RS09145	COG1160	GTP binding
CWC46_RS09150	COG1645	bacterial-type flagellum-dependent swarming motility
CWC46_RS09165	COG1570	exodeoxyribonuclease VII activity
CWC46_RS09170	COG0516	GMP reductase activity
CWC46_RS09170	COG0517	IMP dehydrogenase activity
CWC46_RS09175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWC46_RS09175	COG0519	Catalyzes the synthesis of GMP from XMP
CWC46_RS09180	COG0582	viral genome integration into host DNA
CWC46_RS09210	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS09215	COG1959	2 iron, 2 sulfur cluster binding
CWC46_RS09220	COG3328	transposase activity
CWC46_RS09255	COG2003	Belongs to the UPF0758 family
CWC46_RS09270	COG0583	DNA-binding transcription factor activity
CWC46_RS09275	COG0655	NAD(P)H dehydrogenase (quinone) activity
CWC46_RS09300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CWC46_RS09305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWC46_RS09310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CWC46_RS09315	COG3958	Transketolase
CWC46_RS09325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWC46_RS09345	COG3436	PFAM IS66 Orf2 family protein
CWC46_RS09360	COG0583	DNA-binding transcription factor activity
CWC46_RS09370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWC46_RS09380	COG4166	transmembrane transport
CWC46_RS09395	COG1609	Transcriptional regulator
CWC46_RS09400	COG0483	inositol monophosphate 1-phosphatase activity
CWC46_RS09410	COG3842	ATPase activity
CWC46_RS09415	COG3833	ABC-type maltose transport systems, permease component
CWC46_RS09425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CWC46_RS09435	COG3223	Belongs to the PsiE family
CWC46_RS09445	COG0435	Glutathione S-transferase
CWC46_RS09450	COG0745	RESPONSE REGULATOR receiver
CWC46_RS09455	COG2205	protein histidine kinase activity
CWC46_RS09460	COG0477	Major facilitator Superfamily
CWC46_RS09465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC46_RS09470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC46_RS09475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC46_RS09480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CWC46_RS09490	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CWC46_RS09490	COG2885	chlorophyll binding
CWC46_RS09495	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CWC46_RS09500	COG3070	regulator of competence-specific genes
CWC46_RS09505	COG1289	transmembrane transporter activity
CWC46_RS09510	COG3304	Inner membrane component domain
CWC46_RS09515	COG0210	DNA helicase
CWC46_RS09520	COG1803	Methylglyoxal synthase
CWC46_RS09525	COG1832	CoA-binding protein
CWC46_RS09530	COG3785	DNA binding
CWC46_RS09535	COG1254	Belongs to the acylphosphatase family
CWC46_RS09540	COG2920	part of a sulfur-relay system
CWC46_RS09545	COG0670	Belongs to the BI1 family
CWC46_RS09575	COG0589	response to stress
CWC46_RS09580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CWC46_RS09590	COG0248	Ppx GppA phosphatase
CWC46_RS09595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CWC46_RS09610	COG1760	l-serine dehydratase
CWC46_RS09615	COG0814	amino acid
CWC46_RS09620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CWC46_RS09625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWC46_RS09630	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CWC46_RS09635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CWC46_RS09645	COG0215	cysteine-tRNA ligase activity
CWC46_RS09650	COG2501	S4 domain
CWC46_RS09655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWC46_RS09665	COG1228	amidohydrolase
CWC46_RS09670	COG0402	S-adenosylhomocysteine deaminase activity
CWC46_RS09695	COG4598	ABC transporter
CWC46_RS09700	COG2986	histidine ammonia-lyase
CWC46_RS09720	COG1116	anion transmembrane transporter activity
CWC46_RS09730	COG1473	amidohydrolase
CWC46_RS09755	COG3037	sugar-specific permease SgaT UlaA
CWC46_RS09765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS09775	COG3684	Belongs to the aldolase LacD family
CWC46_RS09780	COG2390	Transcriptional regulator
CWC46_RS09840	COG0110	maltose O-acetyltransferase activity
CWC46_RS09845	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CWC46_RS09850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWC46_RS09855	COG0297	glycogen (starch) synthase activity
CWC46_RS09865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWC46_RS09880	COG0583	DNA-binding transcription factor activity
CWC46_RS09885	COG0477	Major facilitator Superfamily
CWC46_RS09890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CWC46_RS09900	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS09905	COG0454	-acetyltransferase
CWC46_RS09955	COG2814	Major facilitator Superfamily
CWC46_RS09980	COG4948	Mandelate Racemase Muconate Lactonizing
CWC46_RS10000	COG0436	Aminotransferase
CWC46_RS10010	COG3266	domain, Protein
CWC46_RS10015	COG3031	protein transport across the cell outer membrane
CWC46_RS10100	COG0513	Belongs to the DEAD box helicase family
CWC46_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS10115	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CWC46_RS10120	COG2873	o-acetylhomoserine
CWC46_RS10160	COG4372	Transposase
CWC46_RS10175	COG0582	viral genome integration into host DNA
CWC46_RS10190	COG2067	long-chain fatty acid transport protein
CWC46_RS10195	COG3691	Protein conserved in bacteria
CWC46_RS10200	COG0183	Belongs to the thiolase family
CWC46_RS10205	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWC46_RS10205	COG1024	Enoyl-CoA hydratase
CWC46_RS10210	COG2062	phosphohistidine phosphatase, SixA
CWC46_RS10215	COG2840	Smr protein MutS2
CWC46_RS10220	COG2890	protein-(glutamine-N5) methyltransferase activity
CWC46_RS10225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CWC46_RS10230	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CWC46_RS10235	COG0730	response to heat
CWC46_RS10240	COG3101	peptidyl-lysine hydroxylation
CWC46_RS10250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC46_RS10250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CWC46_RS10255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWC46_RS10285	COG0642	Histidine kinase
CWC46_RS10290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC46_RS10295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWC46_RS10300	COG0101	tRNA pseudouridine synthase activity
CWC46_RS10305	COG0586	Pfam SNARE associated Golgi protein
CWC46_RS10310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CWC46_RS10315	COG0285	dihydrofolate synthase activity
CWC46_RS10320	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CWC46_RS10325	COG1286	toxin biosynthetic process
CWC46_RS10330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CWC46_RS10335	COG0163	prenyltransferase activity
CWC46_RS10340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS10345	COG4215	(ABC) transporter
CWC46_RS10350	COG4160	amino acid transport
CWC46_RS10355	COG4598	ABC transporter
CWC46_RS10360	COG1090	epimerase
CWC46_RS10365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CWC46_RS10370	COG0625	glutathione transferase activity
CWC46_RS10375	COG0531	amino acid
CWC46_RS10380	COG4303	Ethanolamine ammonia lyase large subunit
CWC46_RS10385	COG4302	ethanolamine ammonia-lyase activity
CWC46_RS10390	COG0622	Phosphoesterase
CWC46_RS10395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CWC46_RS10400	COG0857	belongs to the CobB CobQ family
CWC46_RS10400	COG0280	phosphate acetyltransferase
CWC46_RS10405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWC46_RS10410	COG3092	negative regulation of chromosome organization
CWC46_RS10415	COG3013	Belongs to the UPF0304 family
CWC46_RS10420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWC46_RS10425	COG0490	domain, Protein
CWC46_RS10425	COG0471	metal ion transport
CWC46_RS10430	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CWC46_RS10435	COG0436	Aminotransferase
CWC46_RS10440	COG0583	DNA-binding transcription factor activity
CWC46_RS10455	COG0649	NAD binding
CWC46_RS10455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWC46_RS10465	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CWC46_RS10475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CWC46_RS10480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWC46_RS10485	COG0839	Belongs to the complex I subunit 6 family
CWC46_RS10490	COG0713	ATP synthesis coupled electron transport
CWC46_RS10495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWC46_RS10500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWC46_RS10505	COG1007	ATP synthesis coupled electron transport
CWC46_RS10515	COG4575	ribosome binding
CWC46_RS10525	COG1960	acyl-CoA dehydrogenase activity
CWC46_RS10595	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWC46_RS10610	COG0488	(ABC) transporter
CWC46_RS10615	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CWC46_RS10620	COG0437	4 iron, 4 sulfur cluster binding
CWC46_RS10625	COG5557	Pfam Polysulphide reductase, NrfD
CWC46_RS10630	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CWC46_RS10635	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CWC46_RS10640	COG1773	rubredoxin
CWC46_RS10650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CWC46_RS10655	COG0298	carbon dioxide binding
CWC46_RS10660	COG0409	Hydrogenase expression formation protein
CWC46_RS10665	COG0309	Hydrogenase expression formation protein (HypE)
CWC46_RS10670	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CWC46_RS10695	COG0243	molybdopterin cofactor binding
CWC46_RS10695	COG3383	formate dehydrogenase (NAD+) activity
CWC46_RS10700	COG0437	4 iron, 4 sulfur cluster binding
CWC46_RS10705	COG2864	formate dehydrogenase
CWC46_RS10710	COG3058	Necessary for formate dehydrogenase activity
CWC46_RS10715	COG0698	ribose 5-phosphate isomerase
CWC46_RS10720	COG1737	Transcriptional regulator
CWC46_RS10730	COG1879	ABC-type sugar transport system periplasmic component
CWC46_RS10735	COG1129	ABC transporter
CWC46_RS10740	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS10745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWC46_RS10750	COG1940	carbohydrate kinase activity
CWC46_RS10755	COG2814	Major facilitator Superfamily
CWC46_RS10765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC46_RS10770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC46_RS10785	COG0436	Aminotransferase
CWC46_RS10790	COG0583	DNA-binding transcription factor activity
CWC46_RS10810	COG1819	glycosyl
CWC46_RS10815	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS10820	COG1535	isochorismatase
CWC46_RS10820	COG3433	isochorismatase activity
CWC46_RS10825	COG1021	2,3-dihydroxybenzoate-AMP ligase
CWC46_RS10830	COG1169	isochorismate synthase
CWC46_RS10835	COG4774	siderophore transport
CWC46_RS10840	COG2382	esterase
CWC46_RS10845	COG3251	PFAM MbtH domain protein
CWC46_RS10855	COG1120	ATPase activity
CWC46_RS10860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWC46_RS10865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWC46_RS10870	COG0477	Major facilitator Superfamily
CWC46_RS10875	COG4592	Periplasmic binding protein
CWC46_RS10880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWC46_RS10885	COG3711	transcriptional antiterminator
CWC46_RS10890	COG1263	PTS System
CWC46_RS10890	COG2190	(PTS) system
CWC46_RS10890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWC46_RS10895	COG2723	6-phospho-beta-galactosidase activity
CWC46_RS10915	COG0730	response to heat
CWC46_RS10920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWC46_RS10930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWC46_RS10930	COG2169	Transcriptional regulator
CWC46_RS10940	COG2203	Gaf domain
CWC46_RS10940	COG5001	Diguanylate cyclase
CWC46_RS10940	COG3706	GGDEF domain
CWC46_RS10940	COG4251	negative regulation of phosphorylation
CWC46_RS10950	COG2182	Extracellular solute-binding protein
CWC46_RS10955	COG1175	transmembrane transport
CWC46_RS10960	COG3833	ABC-type maltose transport systems, permease component
CWC46_RS10965	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CWC46_RS10970	COG1874	Beta-galactosidase
CWC46_RS10975	COG1263	PTS System
CWC46_RS10975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWC46_RS10990	COG3459	Glycosyltransferase 36 associated
CWC46_RS10995	COG0148	phosphopyruvate hydratase activity
CWC46_RS11005	COG1556	Lactate utilization protein
CWC46_RS11010	COG1139	Iron-sulfur cluster binding protein
CWC46_RS11015	COG0247	lactate metabolic process
CWC46_RS11030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWC46_RS11035	COG0738	Major facilitator superfamily
CWC46_RS11040	COG0583	DNA-binding transcription factor activity
CWC46_RS11045	COG2271	Major facilitator Superfamily
CWC46_RS11065	COG4670	ketone body catabolic process
CWC46_RS11070	COG1960	acyl-CoA dehydrogenase activity
CWC46_RS11075	COG1917	Cupin 2, conserved barrel domain protein
CWC46_RS11075	COG2207	Transcriptional regulator
CWC46_RS11080	COG2086	electron transfer activity
CWC46_RS11085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWC46_RS11090	COG0644	oxidoreductase
CWC46_RS11095	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CWC46_RS11100	COG0318	PFAM AMP-dependent synthetase and ligase
CWC46_RS11120	COG1960	acyl-CoA dehydrogenase activity
CWC46_RS11130	COG0583	DNA-binding transcription factor activity
CWC46_RS11135	COG1175	transmembrane transport
CWC46_RS11160	COG3842	ATPase activity
CWC46_RS11170	COG3228	Belongs to the MtfA family
CWC46_RS11180	COG3706	GGDEF domain
CWC46_RS11200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWC46_RS11205	COG0303	'Molybdopterin
CWC46_RS11210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS11215	COG0281	malic enzyme
CWC46_RS11220	COG0295	cytidine deaminase activity
CWC46_RS11225	COG1346	cytolysis
CWC46_RS11230	COG1380	Effector of murein hydrolase LrgA
CWC46_RS11245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWC46_RS11250	COG0156	8-amino-7-oxononanoate synthase activity
CWC46_RS11255	COG2226	methyltransferase
CWC46_RS11260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CWC46_RS11270	COG0583	DNA-binding transcription factor activity
CWC46_RS11275	COG2828	Protein conserved in bacteria
CWC46_RS11280	COG2814	Major facilitator Superfamily
CWC46_RS11285	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWC46_RS11295	COG3052	prosthetic group binding
CWC46_RS11315	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CWC46_RS11330	COG0534	Mate efflux family protein
CWC46_RS11340	COG0840	transmembrane signaling receptor activity
CWC46_RS11365	COG0643	Histidine kinase
CWC46_RS11365	COG2198	Histidine kinase
CWC46_RS11370	COG0835	chemotaxis
CWC46_RS11375	COG0840	transmembrane signaling receptor activity
CWC46_RS11380	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CWC46_RS11385	COG2201	protein-glutamate methylesterase activity
CWC46_RS11390	COG0745	RESPONSE REGULATOR receiver
CWC46_RS11395	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CWC46_RS11400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWC46_RS11405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWC46_RS11415	COG3418	PFAM FlgN family protein
CWC46_RS11420	COG2747	anti-sigma28 factor FlgM
CWC46_RS11430	COG1815	bacterial-type flagellum-dependent cell motility
CWC46_RS11435	COG1558	bacterial-type flagellum-dependent cell motility
CWC46_RS11440	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CWC46_RS11445	COG1749	Flagellar hook protein flgE
CWC46_RS11450	COG4787	bacterial-type flagellum-dependent cell motility
CWC46_RS11460	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CWC46_RS11465	COG1706	bacterial-type flagellum-dependent cell motility
CWC46_RS11475	COG1256	bacterial-type flagellum assembly
CWC46_RS11480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWC46_RS11515	COG1580	Controls the rotational direction of flagella during chemotaxis
CWC46_RS11525	COG2882	bacterial-type flagellum organization
CWC46_RS11535	COG1317	bacterial-type flagellum organization
CWC46_RS11550	COG1677	Flagellar hook-basal body complex protein FliE
CWC46_RS11565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CWC46_RS11575	COG0438	transferase activity, transferring glycosyl groups
CWC46_RS11575	COG1216	Glycosyl transferase, family 2
CWC46_RS11595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWC46_RS11600	COG0673	inositol 2-dehydrogenase activity
CWC46_RS11610	COG1191	sigma factor activity
CWC46_RS11620	COG1702	phosphate starvation-inducible protein PhoH
CWC46_RS11640	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CWC46_RS11660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWC46_RS11665	COG1067	ATP-dependent peptidase activity
CWC46_RS11695	COG0840	transmembrane signaling receptor activity
CWC46_RS11700	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CWC46_RS11705	COG2943	transferase activity, transferring hexosyl groups
CWC46_RS11710	COG2814	Major facilitator Superfamily
CWC46_RS11715	COG1560	Kdo2-lipid A biosynthetic process
CWC46_RS11730	COG0418	dihydroorotase activity
CWC46_RS11735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CWC46_RS11740	COG1530	ribonuclease E activity
CWC46_RS11745	COG0564	pseudouridine synthase activity
CWC46_RS11750	COG0424	maF-like protein
CWC46_RS11755	COG1399	metal-binding, possibly nucleic acid-binding protein
CWC46_RS11760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CWC46_RS11765	COG0416	fatty acid biosynthetic process
CWC46_RS11770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWC46_RS11785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWC46_RS11790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWC46_RS11795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWC46_RS11800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CWC46_RS11805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWC46_RS11810	COG0470	DNA polymerase III
CWC46_RS11815	COG0084	hydrolase, TatD family'
CWC46_RS11820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWC46_RS11820	COG1263	PTS System
CWC46_RS11825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CWC46_RS11830	COG0537	adenosine 5'-monophosphoramidase activity
CWC46_RS11835	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CWC46_RS11845	COG1472	Belongs to the glycosyl hydrolase 3 family
CWC46_RS11850	COG3150	esterase
CWC46_RS11855	COG1252	NADH dehydrogenase
CWC46_RS11860	COG3134	Outer membrane lipoprotein
CWC46_RS11870	COG2271	Major facilitator Superfamily
CWC46_RS11885	COG0443	Heat shock 70 kDa protein
CWC46_RS11890	COG2200	EAL domain
CWC46_RS11895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CWC46_RS11900	COG4591	ABC-type transport system involved in lipoprotein release permease component
CWC46_RS11905	COG1136	(ABC) transporter
CWC46_RS11910	COG4591	ABC-type transport system involved in lipoprotein release permease component
CWC46_RS11915	COG1940	carbohydrate kinase activity
CWC46_RS11925	COG4139	cobalamin transport
CWC46_RS11930	COG0386	Belongs to the glutathione peroxidase family
CWC46_RS11935	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CWC46_RS11940	COG0791	NLP P60 protein
CWC46_RS11945	COG0095	Lipoate-protein ligase
CWC46_RS11950	COG2200	EAL domain
CWC46_RS11955	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CWC46_RS11960	COG2989	Protein conserved in bacteria
CWC46_RS11965	COG3108	Peptidase M15
CWC46_RS11970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWC46_RS11975	COG1448	Aminotransferase
CWC46_RS11980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CWC46_RS11990	COG0017	Asparaginyl-tRNA synthetase
CWC46_RS11995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CWC46_RS12000	COG0308	aminopeptidase N
CWC46_RS12005	COG0167	dihydroorotate dehydrogenase activity
CWC46_RS12015	COG0633	Ferredoxin
CWC46_RS12015	COG3217	Mosc domain protein beta barrel domain protein
CWC46_RS12020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CWC46_RS12020	COG0116	Belongs to the methyltransferase superfamily
CWC46_RS12025	COG0488	(ABC) transporter
CWC46_RS12030	COG2995	paraquat-inducible protein a
CWC46_RS12035	COG3008	intermembrane lipid transfer
CWC46_RS12035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CWC46_RS12040	COG3009	Protein conserved in bacteria
CWC46_RS12045	COG3130	regulation of translation
CWC46_RS12050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CWC46_RS12055	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CWC46_RS12060	COG0574	Belongs to the PEP-utilizing enzyme family
CWC46_RS12060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWC46_RS12070	COG0628	permease
CWC46_RS12075	COG0247	lactate metabolic process
CWC46_RS12075	COG0277	FAD linked oxidase domain protein
CWC46_RS12080	COG2050	protein possibly involved in aromatic compounds catabolism
CWC46_RS12085	COG0316	Belongs to the HesB IscA family
CWC46_RS12090	COG0719	Fe-S assembly protein
CWC46_RS12095	COG0396	ATPase activity
CWC46_RS12100	COG0719	Fe-S assembly protein
CWC46_RS12105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWC46_RS12110	COG2166	iron-sulfur cluster assembly
CWC46_RS12115	COG1388	LysM domain
CWC46_RS12115	COG1376	ErfK ybiS ycfS ynhG family protein
CWC46_RS12120	COG4238	major outer membrane lipoprotein
CWC46_RS12150	COG2382	esterase
CWC46_RS12170	COG2423	ornithine cyclodeaminase activity
CWC46_RS12215	COG0534	Mate efflux family protein
CWC46_RS12220	COG0307	riboflavin synthase, alpha
CWC46_RS12225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CWC46_RS12230	COG1609	Transcriptional regulator
CWC46_RS12240	COG0791	NLP P60 protein
CWC46_RS12245	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CWC46_RS12250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWC46_RS12260	COG3313	Fe-S protein
CWC46_RS12270	COG3133	Outer membrane lipoprotein
CWC46_RS12275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CWC46_RS12280	COG3895	Periplasmic Protein
CWC46_RS12285	COG0259	pyridoxamine-phosphate oxidase activity
CWC46_RS12290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CWC46_RS12295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CWC46_RS12310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWC46_RS12315	COG0671	phosphoesterase, PA-phosphatase related
CWC46_RS12320	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CWC46_RS12325	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CWC46_RS12330	COG0284	orotidine-5'-phosphate decarboxylase activity
CWC46_RS12335	COG0023	Translation Initiation Factor
CWC46_RS12345	COG0235	Class ii aldolase
CWC46_RS12350	COG4989	oxidoreductase activity
CWC46_RS12355	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CWC46_RS12360	COG0243	molybdopterin cofactor binding
CWC46_RS12365	COG0583	DNA-binding transcription factor activity
CWC46_RS12395	COG4166	transmembrane transport
CWC46_RS12405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWC46_RS12410	COG1842	Phage shock protein A
CWC46_RS12420	COG1983	PspC domain protein
CWC46_RS12425	COG3106	COG3106 Predicted ATPase
CWC46_RS12430	COG3768	UPF0283 membrane protein
CWC46_RS12435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWC46_RS12455	COG0477	Major facilitator Superfamily
CWC46_RS12460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CWC46_RS12465	COG2866	Carboxypeptidase
CWC46_RS12475	COG4166	transmembrane transport
CWC46_RS12480	COG0598	Magnesium transport protein CorA
CWC46_RS12485	COG0037	tRNA processing
CWC46_RS12495	COG0583	DNA-binding transcription factor activity
CWC46_RS12505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWC46_RS12510	COG0840	transmembrane signaling receptor activity
CWC46_RS12515	COG0840	transmembrane signaling receptor activity
CWC46_RS12520	COG2911	Protein conserved in bacteria
CWC46_RS12530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CWC46_RS12535	COG1643	Atp-dependent helicase
CWC46_RS12540	COG3591	Belongs to the peptidase S1B family
CWC46_RS12550	COG2205	protein histidine kinase activity
CWC46_RS12555	COG0745	RESPONSE REGULATOR receiver
CWC46_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS12570	COG0659	secondary active sulfate transmembrane transporter activity
CWC46_RS12575	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CWC46_RS12590	COG2197	response regulator
CWC46_RS12595	COG3850	Histidine kinase
CWC46_RS12600	COG2223	nitrite transmembrane transporter activity
CWC46_RS12605	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CWC46_RS12610	COG1140	nitrate reductase beta subunit
CWC46_RS12615	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CWC46_RS12620	COG2181	nitrate reductase activity
CWC46_RS12650	COG0679	Auxin Efflux Carrier
CWC46_RS12660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CWC46_RS12675	COG2261	transglycosylase associated protein
CWC46_RS12680	COG3842	ATPase activity
CWC46_RS12690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CWC46_RS12695	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS12705	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWC46_RS12740	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CWC46_RS12745	COG4792	protein secretion
CWC46_RS12750	COG4791	protein targeting
CWC46_RS12755	COG4794	Type iii secretion
CWC46_RS12805	COG4585	Histidine kinase
CWC46_RS12810	COG2197	response regulator
CWC46_RS12875	COG2831	hemolysin activation secretion protein
CWC46_RS12880	COG3210	domain, Protein
CWC46_RS12900	COG0358	DNA primase activity
CWC46_RS12905	COG4974	Belongs to the 'phage' integrase family
CWC46_RS12930	COG0358	DNA primase activity
CWC46_RS12935	COG4974	Belongs to the 'phage' integrase family
CWC46_RS13000	COG3609	addiction module antidote protein, CC2985 family
CWC46_RS13035	COG1840	ABC-type Fe3 transport system, periplasmic component
CWC46_RS13040	COG4149	molybdate abc transporter
CWC46_RS13080	COG3964	amidohydrolase
CWC46_RS13095	COG3711	transcriptional antiterminator
CWC46_RS13095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS13120	COG1175	transmembrane transport
CWC46_RS13130	COG3833	ABC-type maltose transport systems, permease component
CWC46_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS13145	COG0434	BtpA family
CWC46_RS13160	COG1349	DNA-binding transcription factor activity
CWC46_RS13165	COG0488	(ABC) transporter
CWC46_RS13180	COG4608	Belongs to the ABC transporter superfamily
CWC46_RS13185	COG4533	DNA binding
CWC46_RS13215	COG1358	cellular component organization or biogenesis
CWC46_RS13290	COG0012	GTP binding
CWC46_RS13295	COG0193	aminoacyl-tRNA hydrolase activity
CWC46_RS13310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWC46_RS13315	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CWC46_RS13320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CWC46_RS13325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWC46_RS13330	COG2890	protein-(glutamine-N5) methyltransferase activity
CWC46_RS13340	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CWC46_RS13350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CWC46_RS13355	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CWC46_RS13360	COG0589	response to stress
CWC46_RS13365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWC46_RS13370	COG2226	methyltransferase
CWC46_RS13375	COG3811	Belongs to the UPF0386 family
CWC46_RS13385	COG3479	Phenolic acid decarboxylase
CWC46_RS13400	COG1940	carbohydrate kinase activity
CWC46_RS13405	COG3842	ATPase activity
CWC46_RS13410	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWC46_RS13415	COG1177	transmembrane transport
CWC46_RS13425	COG0584	glycerophosphoryl diester phosphodiesterase
CWC46_RS13430	COG0483	inositol monophosphate 1-phosphatase activity
CWC46_RS13445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWC46_RS13455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWC46_RS13480	COG1733	regulation of RNA biosynthetic process
CWC46_RS13485	COG0702	epimerase
CWC46_RS13490	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CWC46_RS13500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWC46_RS13505	COG4977	sequence-specific DNA binding
CWC46_RS13545	COG3622	Belongs to the hyi family
CWC46_RS13575	COG1215	transferase activity, transferring glycosyl groups
CWC46_RS13580	COG0667	Aldo Keto reductase
CWC46_RS13585	COG4221	oxidoreductase activity
CWC46_RS13595	COG0628	permease
CWC46_RS13610	COG1940	carbohydrate kinase activity
CWC46_RS13615	COG0583	DNA-binding transcription factor activity
CWC46_RS13620	COG2814	Major facilitator Superfamily
CWC46_RS13630	COG2223	nitrite transmembrane transporter activity
CWC46_RS13640	COG0114	fumarate hydratase activity
CWC46_RS13645	COG1482	cell wall glycoprotein biosynthetic process
CWC46_RS13650	COG5339	Protein conserved in bacteria
CWC46_RS13655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CWC46_RS13665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWC46_RS13670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWC46_RS13675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWC46_RS13685	COG0356	it plays a direct role in the translocation of protons across the membrane
CWC46_RS13705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWC46_RS13710	COG0385	Bile acid
CWC46_RS13715	COG0673	inositol 2-dehydrogenase activity
CWC46_RS13725	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS13730	COG1129	ABC transporter
CWC46_RS13735	COG1879	ABC-type sugar transport system periplasmic component
CWC46_RS13740	COG1069	ribulokinase activity
CWC46_RS13745	COG2160	L-arabinose isomerase activity
CWC46_RS13750	COG4657	Part of a membrane complex involved in electron transport
CWC46_RS13755	COG2878	Part of a membrane complex involved in electron transport
CWC46_RS13760	COG4656	Part of a membrane complex involved in electron transport
CWC46_RS13765	COG4658	electron transport chain
CWC46_RS13770	COG4659	FMN binding
CWC46_RS13780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWC46_RS13785	COG3104	oligopeptide transport
CWC46_RS13805	COG2226	methyltransferase
CWC46_RS13810	COG0616	signal peptide processing
CWC46_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS13825	COG1187	pseudouridine synthase activity
CWC46_RS13830	COG0009	L-threonylcarbamoyladenylate synthase
CWC46_RS13835	COG0613	PHP domain protein
CWC46_RS13845	COG0512	Glutamine amidotransferase of anthranilate synthase
CWC46_RS13850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CWC46_RS13855	COG0134	indole-3-glycerol-phosphate synthase activity
CWC46_RS13855	COG0135	phosphoribosylanthranilate isomerase activity
CWC46_RS13860	COG0133	tryptophan synthase activity
CWC46_RS13865	COG0159	tryptophan synthase activity
CWC46_RS13870	COG3047	cAMP biosynthetic process
CWC46_RS13875	COG0727	PFAM Uncharacterised protein family (UPF0153)
CWC46_RS13885	COG2917	probably involved in intracellular septation
CWC46_RS13900	COG2350	Protein conserved in bacteria
CWC46_RS13905	COG0840	transmembrane signaling receptor activity
CWC46_RS13910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWC46_RS13930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS13935	COG0601	transmembrane transport
CWC46_RS13945	COG2095	MarC family integral membrane protein
CWC46_RS13950	COG1454	alcohol dehydrogenase
CWC46_RS13950	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS13960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWC46_RS13965	COG0745	RESPONSE REGULATOR receiver
CWC46_RS13970	COG1752	Esterase of the alpha-beta hydrolase superfamily
CWC46_RS13975	COG3012	SEC-C Motif Domain Protein
CWC46_RS13980	COG0788	formyltetrahydrofolate deformylase activity
CWC46_RS13995	COG2860	membrane
CWC46_RS14000	COG0708	Exodeoxyribonuclease III
CWC46_RS14010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWC46_RS14015	COG0778	Nitroreductase
CWC46_RS14020	COG0616	signal peptide processing
CWC46_RS14025	COG0252	asparaginase activity
CWC46_RS14030	COG1335	isochorismatase
CWC46_RS14035	COG3139	Protein of unknown function (DUF1315)
CWC46_RS14040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWC46_RS14055	COG0656	L-ascorbic acid biosynthetic process
CWC46_RS14060	COG3713	MltA-interacting MipA family protein
CWC46_RS14065	COG2766	serine protein kinase
CWC46_RS14070	COG2718	Belongs to the UPF0229 family
CWC46_RS14075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC46_RS14080	COG2719	SpoVR family
CWC46_RS14085	COG2186	Transcriptional regulator
CWC46_RS14090	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CWC46_RS14095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CWC46_RS14235	COG3566	protein conserved in bacteria
CWC46_RS14245	COG3567	Phage-associated protein, HI1409 family
CWC46_RS14250	COG5410	chromosome segregation
CWC46_RS14305	COG1598	PFAM Uncharacterised protein family UPF0150
CWC46_RS14310	COG1724	mRNA binding
CWC46_RS14400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWC46_RS14425	COG0582	viral genome integration into host DNA
CWC46_RS14430	COG2983	Belongs to the UPF0260 family
CWC46_RS14435	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWC46_RS14445	COG0850	regulation of cytokinetic process
CWC46_RS14450	COG2894	cell division
CWC46_RS14455	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CWC46_RS14460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CWC46_RS14465	COG0318	PFAM AMP-dependent synthetase and ligase
CWC46_RS14470	COG3065	identical protein binding
CWC46_RS14480	COG1199	ATP-dependent helicase activity
CWC46_RS14485	COG0251	oxidation-reduction process
CWC46_RS14500	COG0494	nUDIX hydrolase
CWC46_RS14505	COG1760	l-serine dehydratase
CWC46_RS14510	COG1253	flavin adenine dinucleotide binding
CWC46_RS14515	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS14515	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWC46_RS14520	COG3715	PTS system
CWC46_RS14525	COG3716	PTS system mannose fructose sorbose family IID component
CWC46_RS14530	COG4811	Protein of unknown function (DUF986)
CWC46_RS14535	COG1971	Probably functions as a manganese efflux pump
CWC46_RS14540	COG2226	methyltransferase
CWC46_RS14555	COG3001	Fructosamine kinase
CWC46_RS14565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWC46_RS14570	COG1917	Cupin 2, conserved barrel domain protein
CWC46_RS14575	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CWC46_RS14580	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS14590	COG1175	transmembrane transport
CWC46_RS14595	COG0395	ABC-type sugar transport system, permease component
CWC46_RS14600	COG3842	ATPase activity
CWC46_RS14610	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CWC46_RS14615	COG2755	lipolytic protein G-D-S-L family
CWC46_RS14615	COG0657	acetylesterase activity
CWC46_RS14620	COG1988	membrane-bound metal-dependent
CWC46_RS14625	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWC46_RS14630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CWC46_RS14645	COG0776	regulation of translation
CWC46_RS14650	COG0072	phenylalanine-tRNA ligase activity
CWC46_RS14650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWC46_RS14655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CWC46_RS14660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWC46_RS14670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CWC46_RS14675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWC46_RS14690	COG0823	Involved in the tonB-independent uptake of proteins
CWC46_RS14695	COG0501	Belongs to the peptidase M48B family
CWC46_RS14705	COG0538	isocitrate dehydrogenase activity
CWC46_RS14710	COG1187	pseudouridine synthase activity
CWC46_RS14720	COG0482	sulfurtransferase activity
CWC46_RS14730	COG2915	High frequency lysogenization protein hflD homolog
CWC46_RS14735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWC46_RS14750	COG2850	peptidyl-arginine hydroxylation
CWC46_RS14755	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWC46_RS14785	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CWC46_RS14790	COG1956	GAF domain-containing protein
CWC46_RS14880	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CWC46_RS14915	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CWC46_RS14920	COG5301	cellulose 1,4-beta-cellobiosidase activity
CWC46_RS14925	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CWC46_RS14935	COG2840	Smr protein MutS2
CWC46_RS14980	COG0402	S-adenosylhomocysteine deaminase activity
CWC46_RS15005	COG0640	Transcriptional regulator
CWC46_RS15020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWC46_RS15025	COG2814	Major facilitator Superfamily
CWC46_RS15030	COG1335	isochorismatase
CWC46_RS15040	COG0436	Aminotransferase
CWC46_RS15050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWC46_RS15075	COG4319	ketosteroid isomerase
CWC46_RS15110	COG3093	addiction module antidote protein HigA
CWC46_RS15125	COG1528	Iron-storage protein
CWC46_RS15135	COG1276	copper resistance
CWC46_RS15175	COG1276	copper resistance
CWC46_RS15180	COG2372	response to copper ion
CWC46_RS15185	COG1770	oligopeptidase
CWC46_RS15190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CWC46_RS15195	COG0800	Aldolase
CWC46_RS15200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CWC46_RS15205	COG1737	Transcriptional regulator
CWC46_RS15215	COG1560	Kdo2-lipid A biosynthetic process
CWC46_RS15220	COG0739	heme binding
CWC46_RS15225	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CWC46_RS15230	COG1121	(ABC) transporter
CWC46_RS15235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWC46_RS15240	COG2255	four-way junction helicase activity
CWC46_RS15245	COG0632	four-way junction helicase activity
CWC46_RS15250	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CWC46_RS15260	COG0217	transcriptional regulatory protein
CWC46_RS15265	COG0494	nUDIX hydrolase
CWC46_RS15270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWC46_RS15275	COG1801	Protein of unknown function DUF72
CWC46_RS15280	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CWC46_RS15285	COG2226	methyltransferase
CWC46_RS15290	COG0500	methyltransferase
CWC46_RS15300	COG3142	Participates in the control of copper homeostasis
CWC46_RS15305	COG3102	Protein conserved in bacteria
CWC46_RS15310	COG0018	arginyl-trna synthetase
CWC46_RS15315	COG0728	peptidoglycan biosynthetic process
CWC46_RS15325	COG3132	Protein of unknown function, DUF480
CWC46_RS15330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWC46_RS15335	COG0477	Major facilitator Superfamily
CWC46_RS15345	COG3381	protein complex oligomerization
CWC46_RS15350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWC46_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS15430	COG0277	FAD linked oxidase domain protein
CWC46_RS15445	COG0493	'glutamate synthase
CWC46_RS15450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CWC46_RS15450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CWC46_RS15450	COG1013	pyruvate-flavodoxin oxidoreductase activity
CWC46_RS15450	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWC46_RS15465	COG3220	belongs to the UPF0276 family
CWC46_RS15485	COG1595	DNA-templated transcription, initiation
CWC46_RS15500	COG1733	regulation of RNA biosynthetic process
CWC46_RS15505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWC46_RS15510	COG2132	Multicopper oxidase
CWC46_RS15520	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CWC46_RS15525	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CWC46_RS15530	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CWC46_RS15535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWC46_RS15540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CWC46_RS15545	COG3173	Aminoglycoside phosphotransferase
CWC46_RS15555	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CWC46_RS15560	COG2835	tetraacyldisaccharide 4'-kinase activity
CWC46_RS15565	COG1663	tetraacyldisaccharide 4'-kinase activity
CWC46_RS15570	COG1132	(ABC) transporter
CWC46_RS15575	COG0658	competence protein
CWC46_RS15575	COG2333	competence protein COMEC
CWC46_RS15580	COG2926	Belongs to the UPF0265 family
CWC46_RS15585	COG2925	Exonuclease
CWC46_RS15590	COG5499	transcription regulator containing HTH domain
CWC46_RS15600	COG0531	amino acid
CWC46_RS15610	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CWC46_RS15620	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CWC46_RS15640	COG3052	prosthetic group binding
CWC46_RS15645	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CWC46_RS15650	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWC46_RS15655	COG3493	citrate carrier protein
CWC46_RS15665	COG4565	transcriptional regulatory protein
CWC46_RS15675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWC46_RS15680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CWC46_RS15685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWC46_RS15690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWC46_RS15695	COG0131	Imidazoleglycerol-phosphate dehydratase
CWC46_RS15695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CWC46_RS15700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CWC46_RS15705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWC46_RS15710	COG0107	imidazoleglycerol-phosphate synthase activity
CWC46_RS15715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CWC46_RS15715	COG0140	phosphoribosyl-ATP diphosphatase activity
CWC46_RS15720	COG0776	regulation of translation
CWC46_RS15725	COG0539	negative regulation of cytoplasmic translation
CWC46_RS15730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CWC46_RS15735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWC46_RS15740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CWC46_RS15745	COG1944	ATP diphosphatase activity
CWC46_RS15750	COG2116	formate transmembrane transporter activity
CWC46_RS15755	COG1882	Formate acetyltransferase
CWC46_RS15760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CWC46_RS15775	COG0477	Major facilitator Superfamily
CWC46_RS15785	COG3381	protein complex oligomerization
CWC46_RS15790	COG3302	dmso reductase anchor subunit
CWC46_RS15795	COG0437	4 iron, 4 sulfur cluster binding
CWC46_RS15800	COG0243	molybdopterin cofactor binding
CWC46_RS15805	COG0243	molybdopterin cofactor binding
CWC46_RS15810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWC46_RS15815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWC46_RS15820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CWC46_RS15825	COG3107	peptidoglycan biosynthetic process
CWC46_RS15825	COG1674	ftsk spoiiie
CWC46_RS15830	COG1522	sequence-specific DNA binding
CWC46_RS15835	COG0492	ferredoxin-NADP+ reductase activity
CWC46_RS15840	COG4988	ABC transporter
CWC46_RS15845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CWC46_RS15850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CWC46_RS15855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWC46_RS15870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CWC46_RS15875	COG1278	Cold shock
CWC46_RS15880	COG3593	DNA synthesis involved in DNA repair
CWC46_RS15885	COG2431	L-lysine efflux transmembrane transporter activity
CWC46_RS15890	COG1151	hydroxylamine reductase activity
CWC46_RS15895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CWC46_RS15900	COG0702	epimerase
CWC46_RS15905	COG3023	N-Acetylmuramoyl-L-alanine amidase
CWC46_RS15910	COG0393	Putative heavy-metal-binding
CWC46_RS15915	COG1126	abc transporter atp-binding protein
CWC46_RS15920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS15925	COG4215	(ABC) transporter
CWC46_RS15930	COG4160	amino acid transport
CWC46_RS15935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS15940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWC46_RS15950	COG1177	transmembrane transport
CWC46_RS15955	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWC46_RS15960	COG3842	ATPase activity
CWC46_RS15965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CWC46_RS15975	COG0189	ligase activity
CWC46_RS15995	COG0569	domain protein
CWC46_RS15995	COG2985	domain, Protein
CWC46_RS16000	COG1349	DNA-binding transcription factor activity
CWC46_RS16005	COG1686	Belongs to the peptidase S11 family
CWC46_RS16025	COG0625	glutathione transferase activity
CWC46_RS16030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWC46_RS16035	COG2949	membrane
CWC46_RS16040	COG2311	Membrane
CWC46_RS16045	COG0302	gtp cyclohydrolase
CWC46_RS16050	COG0840	transmembrane signaling receptor activity
CWC46_RS16055	COG0583	DNA-binding transcription factor activity
CWC46_RS16080	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWC46_RS16105	COG0833	amino acid
CWC46_RS16110	COG0583	DNA-binding transcription factor activity
CWC46_RS16115	COG2855	membrane
CWC46_RS16120	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CWC46_RS16125	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CWC46_RS16125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWC46_RS16125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWC46_RS16130	COG1105	Belongs to the carbohydrate kinase PfkB family
CWC46_RS16135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS16135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS16150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWC46_RS16155	COG0523	cobalamin synthesis protein
CWC46_RS16200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC46_RS16205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC46_RS16215	COG0318	PFAM AMP-dependent synthetase and ligase
CWC46_RS16240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWC46_RS16260	COG5000	phosphorelay sensor kinase activity
CWC46_RS16275	COG1136	(ABC) transporter
CWC46_RS16275	COG0577	efflux transmembrane transporter activity
CWC46_RS16285	COG0671	phosphoesterase, PA-phosphatase related
CWC46_RS16290	COG0791	NLP P60 protein
CWC46_RS16295	COG4166	transmembrane transport
CWC46_RS16300	COG4174	ABC transporter (Permease)
CWC46_RS16305	COG4239	(ABC) transporter, permease
CWC46_RS16310	COG4172	Belongs to the ABC transporter superfamily
CWC46_RS16320	COG2814	Major facilitator Superfamily
CWC46_RS16335	COG1061	Type III restriction enzyme res subunit
CWC46_RS16350	COG3081	Nucleoid-associated protein
CWC46_RS16355	COG3082	Protein of unknown function (DUF1414)
CWC46_RS16370	COG0582	viral genome integration into host DNA
CWC46_RS16410	COG4221	oxidoreductase activity
CWC46_RS16420	COG1902	pentaerythritol trinitrate reductase activity
CWC46_RS16440	COG3122	Protein conserved in bacteria
CWC46_RS16455	COG0583	DNA-binding transcription factor activity
CWC46_RS16465	COG0531	amino acid
CWC46_RS16480	COG3136	membrane protein required for alginate biosynthesis
CWC46_RS16485	COG4677	pectinesterase activity
CWC46_RS16490	COG0071	Belongs to the small heat shock protein (HSP20) family
CWC46_RS16500	COG1984	allophanate hydrolase subunit 2
CWC46_RS16515	COG0511	ligase activity, forming carbon-carbon bonds
CWC46_RS16525	COG0583	DNA-binding transcription factor activity
CWC46_RS16530	COG2807	transmembrane transport
CWC46_RS16535	COG1846	Transcriptional regulator
CWC46_RS16540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CWC46_RS16545	COG5006	permease, DMT superfamily
CWC46_RS16550	COG0783	Belongs to the Dps family
CWC46_RS16555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS16560	COG0765	amino acid transport
CWC46_RS16565	COG1126	abc transporter atp-binding protein
CWC46_RS16575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CWC46_RS16580	COG0659	secondary active sulfate transmembrane transporter activity
CWC46_RS16600	COG1349	DNA-binding transcription factor activity
CWC46_RS16610	COG1686	Belongs to the peptidase S11 family
CWC46_RS16615	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWC46_RS16635	COG0513	Belongs to the DEAD box helicase family
CWC46_RS16640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC46_RS16645	COG1131	(ABC) transporter
CWC46_RS16650	COG0842	Transport permease protein
CWC46_RS16655	COG0842	Transport permease protein
CWC46_RS16660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWC46_RS16665	COG0670	Belongs to the BI1 family
CWC46_RS16675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CWC46_RS16680	COG0315	cyclic pyranopterin monophosphate synthase activity
CWC46_RS16685	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWC46_RS16690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CWC46_RS16695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CWC46_RS16700	COG0556	nucleotide-excision repair
CWC46_RS16740	COG0653	protein targeting
CWC46_RS16780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CWC46_RS16785	COG0322	excinuclease ABC activity
CWC46_RS16790	COG2197	response regulator
CWC46_RS16800	COG1113	amino acid transport
CWC46_RS16820	COG0386	Belongs to the glutathione peroxidase family
CWC46_RS16825	COG0604	alcohol dehydrogenase
CWC46_RS16835	COG1486	melibiose metabolic process
CWC46_RS16840	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWC46_RS16845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWC46_RS16845	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWC46_RS16865	COG1454	alcohol dehydrogenase
CWC46_RS16870	COG1846	Transcriptional regulator
CWC46_RS16875	COG1566	PFAM secretion protein HlyD family protein
CWC46_RS16880	COG2814	Major facilitator Superfamily
CWC46_RS16895	COG2211	Major facilitator Superfamily
CWC46_RS16920	COG4608	Belongs to the ABC transporter superfamily
CWC46_RS16925	COG0444	Belongs to the ABC transporter superfamily
CWC46_RS16930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS16935	COG0601	transmembrane transport
CWC46_RS16945	COG2197	response regulator
CWC46_RS16950	COG2267	carboxylic ester hydrolase activity
CWC46_RS16955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWC46_RS16975	COG0531	amino acid
CWC46_RS16980	COG1982	Orn Lys Arg decarboxylase major
CWC46_RS16985	COG1438	arginine binding
CWC46_RS16990	COG1288	antiporter activity
CWC46_RS17000	COG0549	Belongs to the carbamate kinase family
CWC46_RS17010	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CWC46_RS17030	COG2822	iron ion transport
CWC46_RS17035	COG0672	)-iron permease
CWC46_RS17040	COG1342	Belongs to the UPF0251 family
CWC46_RS17050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWC46_RS17055	COG0840	transmembrane signaling receptor activity
CWC46_RS17065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CWC46_RS17070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC46_RS17095	COG0601	transmembrane transport
CWC46_RS17105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC46_RS17115	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS17130	COG2211	Major facilitator Superfamily
CWC46_RS17155	COG3639	organic phosphonate transmembrane transporter activity
CWC46_RS17165	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CWC46_RS17175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CWC46_RS17180	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CWC46_RS17185	COG3454	Phosphonate metabolism
CWC46_RS17190	COG4778	phosphonate C-P lyase system protein PhnL
CWC46_RS17195	COG4107	phosphonate C-P lyase system protein PhnK
CWC46_RS17200	COG3627	carbon phosphorus lyase activity
CWC46_RS17205	COG3626	phosphonate metabolism
CWC46_RS17210	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CWC46_RS17225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWC46_RS17230	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS17240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CWC46_RS17245	COG1301	dicarboxylic acid transport
CWC46_RS17250	COG0697	spore germination
CWC46_RS17255	COG0298	carbon dioxide binding
CWC46_RS17260	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWC46_RS17265	COG0651	ATP synthesis coupled electron transport
CWC46_RS17270	COG0650	Formate hydrogenlyase subunit 4
CWC46_RS17275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWC46_RS17280	COG4237	Hydrogenase 4 membrane
CWC46_RS17285	COG0651	ATP synthesis coupled electron transport
CWC46_RS17290	COG3261	NADH dehydrogenase
CWC46_RS17290	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CWC46_RS17295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWC46_RS17300	COG3260	NADH ubiquinone oxidoreductase 20
CWC46_RS17310	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CWC46_RS17320	COG0019	diaminopimelate decarboxylase activity
CWC46_RS17325	COG2431	L-lysine efflux transmembrane transporter activity
CWC46_RS17330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWC46_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS17345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWC46_RS17350	COG1414	Transcriptional regulator
CWC46_RS17385	COG2814	Major facilitator Superfamily
CWC46_RS17390	COG1802	Transcriptional regulator
CWC46_RS17400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWC46_RS17405	COG3383	formate dehydrogenase (NAD+) activity
CWC46_RS17420	COG1301	dicarboxylic acid transport
CWC46_RS17425	COG0583	DNA-binding transcription factor activity
CWC46_RS17445	COG0582	viral genome integration into host DNA
CWC46_RS17450	COG0604	alcohol dehydrogenase
CWC46_RS17465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC46_RS17510	COG0583	DNA-binding transcription factor activity
CWC46_RS17545	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS17550	COG0740	serine-type endopeptidase activity
CWC46_RS17560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWC46_RS17565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CWC46_RS17570	COG1882	Formate acetyltransferase
CWC46_RS17575	COG1349	DNA-binding transcription factor activity
CWC46_RS17580	COG0784	Response regulator, receiver
CWC46_RS17580	COG0835	chemotaxis
CWC46_RS17590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS17595	COG0601	transmembrane transport
CWC46_RS17610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWC46_RS17615	COG0747	negative chemotaxis
CWC46_RS17635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC46_RS17660	COG2130	NADP-dependent
CWC46_RS17680	COG1105	Belongs to the carbohydrate kinase PfkB family
CWC46_RS17690	COG0484	heat shock protein binding
CWC46_RS17695	COG3545	Serine hydrolase
CWC46_RS17700	COG4608	Belongs to the ABC transporter superfamily
CWC46_RS17705	COG0444	Belongs to the ABC transporter superfamily
CWC46_RS17710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWC46_RS17715	COG0601	transmembrane transport
CWC46_RS17720	COG0747	negative chemotaxis
CWC46_RS17725	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CWC46_RS17740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC46_RS17745	COG0300	oxidoreductase activity
CWC46_RS17745	COG1028	Short-chain dehydrogenase reductase Sdr
CWC46_RS17745	COG0318	PFAM AMP-dependent synthetase and ligase
CWC46_RS17745	COG3321	synthase
CWC46_RS17745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC46_RS17780	COG5002	protein histidine kinase activity
CWC46_RS17785	COG0745	RESPONSE REGULATOR receiver
CWC46_RS17800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC46_RS17830	COG0745	RESPONSE REGULATOR receiver
CWC46_RS17835	COG5002	protein histidine kinase activity
CWC46_RS17835	COG5000	phosphorelay sensor kinase activity
CWC46_RS17850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWC46_RS17870	COG1253	flavin adenine dinucleotide binding
CWC46_RS17875	COG2982	Protein involved in outer membrane biogenesis
CWC46_RS17880	COG0717	Belongs to the dCTP deaminase family
CWC46_RS17885	COG0572	uridine kinase
CWC46_RS17900	COG2706	6-phosphogluconolactonase activity
CWC46_RS17905	COG0561	phosphatase activity
CWC46_RS17910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CWC46_RS17915	COG4149	molybdate abc transporter
CWC46_RS17920	COG0725	ABC transporter, periplasmic molybdate-binding protein
CWC46_RS17930	COG2005	Transcriptional regulator
CWC46_RS17930	COG3585	molybdate ion transport
CWC46_RS17935	COG1119	ATPase activity
CWC46_RS17940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CWC46_RS17945	COG1085	galactose-1-phosphate uridylyltransferase
CWC46_RS17950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CWC46_RS17955	COG2017	converts alpha-aldose to the beta-anomer
CWC46_RS17960	COG0588	phosphoglycerate mutase activity
CWC46_RS17965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CWC46_RS17970	COG1230	cation diffusion facilitator family transporter
CWC46_RS17980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CWC46_RS17985	COG1811	Na channel or pump
CWC46_RS17995	COG1289	transmembrane transporter activity
CWC46_RS18025	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CWC46_RS18030	COG2885	chlorophyll binding
CWC46_RS18035	COG0823	Involved in the tonB-independent uptake of proteins
CWC46_RS18040	COG3064	Membrane
CWC46_RS18045	COG0848	biopolymer transport protein
CWC46_RS18050	COG0811	peptide transport
CWC46_RS18055	COG0824	Thioesterase
CWC46_RS18060	COG3790	cyd operon protein YbgE
CWC46_RS18065	COG4890	Cyd operon protein YbgT
CWC46_RS18070	COG1294	oxidase, subunit
CWC46_RS18075	COG1271	oxidase subunit
CWC46_RS18080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CWC46_RS18085	COG0045	succinate-CoA ligase (ADP-forming) activity
CWC46_RS18090	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWC46_RS18095	COG0567	Dehydrogenase, E1 component
CWC46_RS18100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWC46_RS18105	COG1053	succinate dehydrogenase
CWC46_RS18110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CWC46_RS18120	COG0372	Belongs to the citrate synthase family
CWC46_RS18125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CWC46_RS18130	COG1984	allophanate hydrolase subunit 2
CWC46_RS18135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CWC46_RS18140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWC46_RS18150	COG3272	Protein of unknown function (DUF1722)
CWC46_RS18165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CWC46_RS18170	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CWC46_RS18175	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CWC46_RS18180	COG2205	protein histidine kinase activity
CWC46_RS18185	COG0745	RESPONSE REGULATOR receiver
CWC46_RS18195	COG0033	Phosphoglucomutase
CWC46_RS18200	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CWC46_RS18205	COG0596	Alpha beta hydrolase
CWC46_RS18215	COG0840	transmembrane signaling receptor activity
CWC46_RS18220	COG0716	FMN binding
CWC46_RS18225	COG0735	belongs to the Fur family
CWC46_RS18230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWC46_RS18235	COG2190	(PTS) system
CWC46_RS18235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWC46_RS18235	COG1263	PTS System
CWC46_RS18240	COG0363	glucosamine-6-phosphate deaminase activity
CWC46_RS18245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWC46_RS18250	COG1940	carbohydrate kinase activity
CWC46_RS18250	COG1846	Transcriptional regulator
CWC46_RS18255	COG0367	asparagine synthase
CWC46_RS18290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWC46_RS18295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWC46_RS18300	COG1702	phosphate starvation-inducible protein PhoH
CWC46_RS18305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWC46_RS18315	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CWC46_RS18325	COG0765	amino acid transport
CWC46_RS18330	COG0765	amino acid transport
CWC46_RS18335	COG1126	abc transporter atp-binding protein
CWC46_RS18340	COG2888	peptidyl-tyrosine sulfation
CWC46_RS18345	COG0495	leucyl-tRNA aminoacylation
CWC46_RS18350	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CWC46_RS18355	COG1466	dna polymerase III delta subunit
CWC46_RS18360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWC46_RS18365	COG0799	negative regulation of ribosome biogenesis
CWC46_RS18370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CWC46_RS18375	COG0768	penicillin binding
CWC46_RS18380	COG0772	Belongs to the SEDS family
CWC46_RS18385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CWC46_RS18390	COG1686	Belongs to the peptidase S11 family
CWC46_RS18395	COG2921	Belongs to the UPF0250 family
CWC46_RS18400	COG0321	lipoyl(octanoyl) transferase activity
CWC46_RS18405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CWC46_RS18410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWC46_RS18415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWC46_RS18420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CWC46_RS18430	COG1794	racemase activity, acting on amino acids and derivatives
CWC46_RS18445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWC46_RS18450	COG0798	PFAM Bile acid sodium symporter
CWC46_RS18455	COG1393	Belongs to the ArsC family
CWC46_RS18460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWC46_RS18465	COG1876	peptidase activity
CWC46_RS18475	COG0583	DNA-binding transcription factor activity
CWC46_RS18480	COG2851	Citrate transporter
CWC46_RS18495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CWC46_RS18500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CWC46_RS18505	COG0183	Belongs to the thiolase family
CWC46_RS18510	COG0400	carboxylic ester hydrolase activity
CWC46_RS18515	COG1444	tRNA N-acetyltransferase activity
CWC46_RS18520	COG2707	UPF0756 membrane protein
CWC46_RS18525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWC46_RS18530	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CWC46_RS18540	COG2716	regulation of RNA biosynthetic process
CWC46_RS18545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CWC46_RS18550	COG4783	chaperone-mediated protein folding
CWC46_RS18555	COG1393	Belongs to the ArsC family
CWC46_RS18560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWC46_RS18565	COG2233	PERMEase
CWC46_RS18570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWC46_RS18575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWC46_RS18580	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CWC46_RS18585	COG1609	Transcriptional regulator
CWC46_RS18605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS18610	COG0765	amino acid transport
CWC46_RS18620	COG4774	siderophore transport
CWC46_RS18625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CWC46_RS18630	COG4181	ATPase activity
CWC46_RS18635	COG2755	lipolytic protein G-D-S-L family
CWC46_RS18640	COG0300	oxidoreductase activity
CWC46_RS18645	COG3118	belongs to the thioredoxin family
CWC46_RS18665	COG1441	menaquinone biosynthetic process
CWC46_RS18675	COG0596	Alpha beta hydrolase
CWC46_RS18680	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CWC46_RS18685	COG1169	isochorismate synthase
CWC46_RS18690	COG2223	nitrite transmembrane transporter activity
CWC46_RS18695	COG2198	Histidine kinase
CWC46_RS18695	COG0642	Histidine kinase
CWC46_RS18705	COG2205	protein histidine kinase activity
CWC46_RS18705	COG0784	Response regulator, receiver
CWC46_RS18715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWC46_RS18725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWC46_RS18730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWC46_RS18735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CWC46_RS18740	COG0330	HflC and HflK could
CWC46_RS18745	COG1585	Membrane protein implicated in regulation of membrane protease activity
CWC46_RS18755	COG2217	Heavy metal translocating P-type atpase
CWC46_RS18760	COG3735	TraB family
CWC46_RS18765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CWC46_RS18775	COG2186	Transcriptional regulator
CWC46_RS18785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CWC46_RS18785	COG4651	solute:proton antiporter activity
CWC46_RS18790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CWC46_RS18795	COG0563	adenylate kinase activity
CWC46_RS18800	COG0326	Molecular chaperone. Has ATPase activity
CWC46_RS18805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWC46_RS18810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CWC46_RS18820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWC46_RS18825	COG2832	Protein of unknown function (DUF454)
CWC46_RS18840	COG3264	Mechanosensitive ion channel
CWC46_RS18840	COG1196	nuclear chromosome segregation
CWC46_RS18845	COG1309	transcriptional regulator
CWC46_RS18850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC46_RS18855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC46_RS18885	COG3695	enzyme binding
CWC46_RS18890	COG1946	Acyl-CoA thioesterase
CWC46_RS18895	COG0004	ammonium transporteR
CWC46_RS18900	COG0347	Belongs to the P(II) protein family
CWC46_RS18905	COG1132	(ABC) transporter
CWC46_RS18910	COG1132	(ABC) transporter
CWC46_RS18915	COG1522	sequence-specific DNA binding
CWC46_RS18925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CWC46_RS18930	COG1555	photosystem II stabilization
CWC46_RS18935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWC46_RS18940	COG0776	regulation of translation
CWC46_RS18950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWC46_RS18960	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWC46_RS18965	COG0271	Belongs to the BolA IbaG family
CWC46_RS18970	COG3056	Lipoprotein
CWC46_RS18975	COG2223	nitrite transmembrane transporter activity
CWC46_RS18980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CWC46_RS18985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWC46_RS18990	COG1845	cytochrome c oxidase, subunit III
CWC46_RS18995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CWC46_RS19000	COG0109	protoheme IX farnesyltransferase activity
CWC46_RS19005	COG2814	Major facilitator Superfamily
CWC46_RS19010	COG1666	GTP binding
CWC46_RS19015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CWC46_RS19020	COG0693	protein deglycase activity
CWC46_RS19025	COG0301	tRNA thio-modification
CWC46_RS19025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWC46_RS19035	COG1722	exodeoxyribonuclease VII activity
CWC46_RS19040	COG0142	geranyltranstransferase activity
CWC46_RS19045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWC46_RS19055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CWC46_RS19060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWC46_RS19065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWC46_RS19070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWC46_RS19070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWC46_RS19090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWC46_RS19100	COG1862	Preprotein translocase
CWC46_RS19105	COG0343	queuine tRNA-ribosyltransferase activity
CWC46_RS19110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CWC46_RS19115	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CWC46_RS19120	COG0450	alkyl hydroperoxide reductase
CWC46_RS19135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CWC46_RS19140	COG5002	protein histidine kinase activity
CWC46_RS19150	COG0420	3'-5' exonuclease activity
CWC46_RS19155	COG0419	ATPase involved in DNA repair
CWC46_RS19160	COG2974	May be involved in recombination
CWC46_RS19175	COG3123	guanosine phosphorylase activity
CWC46_RS19190	COG0384	phenazine biosynthesis protein PhzF
CWC46_RS19195	COG0454	-acetyltransferase
CWC46_RS19200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWC46_RS19215	COG1247	-acetyltransferase
CWC46_RS19230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CWC46_RS19255	COG0583	DNA-binding transcription factor activity
CWC46_RS19305	COG2824	Alkylphosphonate utilization operon protein PhnA
CWC46_RS19320	COG0840	transmembrane signaling receptor activity
CWC46_RS19325	COG4807	Protein conserved in bacteria
CWC46_RS19330	COG1648	precorrin-2 dehydrogenase activity
CWC46_RS19330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWC46_RS19335	COG0243	molybdopterin cofactor binding
CWC46_RS19340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWC46_RS19340	COG2146	nitrite reductase [NAD(P)H] activity
CWC46_RS19345	COG1116	anion transmembrane transporter activity
CWC46_RS19355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWC46_RS19365	COG3707	response regulator
CWC46_RS19370	COG0778	Nitroreductase
CWC46_RS19380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CWC46_RS19390	COG4681	YaeQ
CWC46_RS19400	COG4568	rho-dependent transcription termination
CWC46_RS19405	COG0037	tRNA processing
CWC46_RS19410	COG0346	lactoylglutathione lyase activity
CWC46_RS19415	COG0825	malonyl-CoA metabolic process
CWC46_RS19420	COG0587	DNA-directed DNA polymerase activity
CWC46_RS19425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWC46_RS19430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CWC46_RS19435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CWC46_RS19440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWC46_RS19445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CWC46_RS19450	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CWC46_RS19455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWC46_RS19460	COG0750	zinc metalloprotease
CWC46_RS19465	COG0575	Belongs to the CDS family
CWC46_RS19470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWC46_RS19475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CWC46_RS19480	COG0233	cytoplasmic translational termination
CWC46_RS19485	COG0528	UMP kinase activity
CWC46_RS19490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWC46_RS19495	COG0052	Belongs to the universal ribosomal protein uS2 family
CWC46_RS19505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CWC46_RS19510	COG2171	N-acyltransferase activity
CWC46_RS19540	COG1611	Belongs to the LOG family
CWC46_RS19545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWC46_RS19550	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CWC46_RS19555	COG2363	Small membrane protein
CWC46_RS19560	COG0583	DNA-binding transcription factor activity
CWC46_RS19570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWC46_RS19575	COG2166	iron-sulfur cluster assembly
CWC46_RS19580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CWC46_RS19590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC46_RS19595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CWC46_RS19610	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWC46_RS19615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWC46_RS19615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CWC46_RS19620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CWC46_RS19625	COG1074	ATP-dependent DNA helicase activity
CWC46_RS19630	COG1025	Belongs to the peptidase M16 family
CWC46_RS19635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CWC46_RS19640	COG4967	type IV pilus modification protein PilV
CWC46_RS19650	COG4795	General secretion pathway protein
CWC46_RS19660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWC46_RS19665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWC46_RS19675	COG0494	nUDIX hydrolase
CWC46_RS19680	COG3066	DNA modification
CWC46_RS19685	COG0861	Integral membrane protein TerC family
CWC46_RS19695	COG0667	Aldo Keto reductase
CWC46_RS19710	COG3171	Protein conserved in bacteria
CWC46_RS19715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWC46_RS19725	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CWC46_RS19730	COG0741	lytic transglycosylase activity
CWC46_RS19740	COG5441	Belongs to the UPF0261 family
CWC46_RS19755	COG1982	Orn Lys Arg decarboxylase major
CWC46_RS19840	COG1280	lysine exporter protein (LysE YggA)
CWC46_RS19850	COG2801	Transposase and inactivated derivatives
CWC46_RS19910	COG1337	RAMP superfamily
CWC46_RS20080	COG0741	lytic transglycosylase activity
CWC46_RS20130	COG0629	single-stranded DNA binding
CWC46_RS20140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWC46_RS20185	COG0305	Participates in initiation and elongation during chromosome replication
CWC46_RS20235	COG2076	Multidrug Resistance protein
CWC46_RS20250	COG1979	alcohol dehydrogenase
CWC46_RS20350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWC46_RS20355	COG1120	ATPase activity
CWC46_RS20395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CWC46_RS20400	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CWC46_RS20430	COG3384	dioxygenase
CWC46_RS20440	COG0583	DNA-binding transcription factor activity
CWC46_RS20445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CWC46_RS20450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CWC46_RS20455	COG2828	Protein conserved in bacteria
CWC46_RS20470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CWC46_RS20475	COG0163	prenyltransferase activity
CWC46_RS20480	COG1846	Transcriptional regulator
CWC46_RS20485	COG1501	Belongs to the glycosyl hydrolase 31 family
CWC46_RS20490	COG2211	Major facilitator Superfamily
CWC46_RS20500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWC46_RS20525	COG4580	involved in the transport of maltose and maltodextrins
CWC46_RS20540	COG2182	Extracellular solute-binding protein
CWC46_RS20545	COG1175	transmembrane transport
CWC46_RS20550	COG3833	ABC-type maltose transport systems, permease component
CWC46_RS20555	COG1640	4-alpha-glucanotransferase
CWC46_RS20560	COG0058	SHG alpha-glucan phosphorylase activity
CWC46_RS20565	COG2909	trisaccharide binding
CWC46_RS20580	COG2985	domain, Protein
CWC46_RS20585	COG0076	glutamate decarboxylase activity
CWC46_RS20595	COG4122	O-methyltransferase activity
CWC46_RS20640	COG0778	Nitroreductase
CWC46_RS20655	COG3321	synthase
CWC46_RS20660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC46_RS20665	COG0156	8-amino-7-oxononanoate synthase activity
CWC46_RS20670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWC46_RS20675	COG1414	Transcriptional regulator
CWC46_RS20675	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWC46_RS20680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWC46_RS20680	COG5322	oxidoreductase activity
CWC46_RS20685	COG0028	Belongs to the TPP enzyme family
CWC46_RS20690	COG0574	Belongs to the PEP-utilizing enzyme family
CWC46_RS20690	COG3848	Pyruvate phosphate dikinase
CWC46_RS20695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CWC46_RS20700	COG1960	acyl-CoA dehydrogenase activity
CWC46_RS20705	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWC46_RS20715	COG0640	Transcriptional regulator
CWC46_RS20735	COG0454	-acetyltransferase
CWC46_RS20755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWC46_RS20760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CWC46_RS20765	COG0583	DNA-binding transcription factor activity
CWC46_RS20770	COG2814	Major facilitator Superfamily
CWC46_RS20780	COG0318	PFAM AMP-dependent synthetase and ligase
CWC46_RS20805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CWC46_RS20805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CWC46_RS20810	COG0583	DNA-binding transcription factor activity
CWC46_RS20815	COG0473	3-isopropylmalate dehydrogenase activity
CWC46_RS20830	COG1175	transmembrane transport
CWC46_RS20835	COG0395	ABC-type sugar transport system, permease component
CWC46_RS20840	COG3842	ATPase activity
CWC46_RS20845	COG1234	tRNA 3'-trailer cleavage
CWC46_RS20860	COG1802	Transcriptional regulator
CWC46_RS20875	COG1904	glucuronate isomerase
CWC46_RS20880	COG0246	Mannitol dehydrogenase
CWC46_RS20885	COG2731	YhcH YjgK YiaL family protein
CWC46_RS20895	COG2271	Major facilitator Superfamily
CWC46_RS20900	COG1063	alcohol dehydrogenase
CWC46_RS20905	COG4948	Mandelate Racemase Muconate Lactonizing
CWC46_RS20925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CWC46_RS20925	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CWC46_RS20935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWC46_RS20945	COG0531	amino acid
CWC46_RS20950	COG3115	cell septum assembly
CWC46_RS20955	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CWC46_RS20965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC46_RS20975	COG2190	(PTS) system
CWC46_RS20980	COG2205	protein histidine kinase activity
CWC46_RS20985	COG0745	RESPONSE REGULATOR receiver
CWC46_RS20990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC46_RS20995	COG1136	(ABC) transporter
CWC46_RS20995	COG0577	efflux transmembrane transporter activity
CWC46_RS21000	COG2837	iron assimilation
CWC46_RS21010	COG0456	acetyltransferase
CWC46_RS21015	COG0408	coproporphyrinogen oxidase activity
CWC46_RS21020	COG1671	Belongs to the UPF0178 family
CWC46_RS21030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWC46_RS21035	COG0494	nUDIX hydrolase
CWC46_RS21040	COG1914	H( )-stimulated, divalent metal cation uptake system
CWC46_RS21045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWC46_RS21050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWC46_RS21055	COG0497	DNA recombination
CWC46_RS21065	COG2914	Belongs to the UPF0125 (RnfH) family
CWC46_RS21070	COG2867	negative regulation of translational initiation
CWC46_RS21075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CWC46_RS21085	COG0582	viral genome integration into host DNA
CWC46_RS21120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CWC46_RS21195	COG0745	RESPONSE REGULATOR receiver
CWC46_RS21200	COG0586	Pfam SNARE associated Golgi protein
CWC46_RS21205	COG0671	phosphoesterase, PA-phosphatase related
CWC46_RS21215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC46_RS21260	COG2951	lytic endotransglycosylase activity
CWC46_RS21265	COG3718	enzyme involved in inositol metabolism
CWC46_RS21275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC46_RS21280	COG0673	inositol 2-dehydrogenase activity
CWC46_RS21285	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS21290	COG1129	ABC transporter
CWC46_RS21300	COG0673	inositol 2-dehydrogenase activity
CWC46_RS21305	COG3962	Belongs to the TPP enzyme family
CWC46_RS21330	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWC46_RS21385	COG0251	oxidation-reduction process
CWC46_RS21390	COG4598	ABC transporter
CWC46_RS21395	COG0765	amino acid transport
CWC46_RS21400	COG0765	amino acid transport
CWC46_RS21405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC46_RS21420	COG1013	pyruvate-flavodoxin oxidoreductase activity
CWC46_RS21420	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWC46_RS21420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWC46_RS21420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CWC46_RS21425	COG1376	ErfK ybiS ycfS ynhG family protein
CWC46_RS21435	COG1566	PFAM secretion protein HlyD family protein
CWC46_RS21440	COG2814	Major facilitator Superfamily
CWC46_RS21445	COG0246	Mannitol dehydrogenase
CWC46_RS21450	COG3655	Transcriptional regulator
CWC46_RS21480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWC46_RS21485	COG0025	NhaP-type Na H and K H
CWC46_RS21495	COG2252	PERMEase
CWC46_RS21505	COG1560	Kdo2-lipid A biosynthetic process
CWC46_RS21515	COG0395	ABC-type sugar transport system, permease component
CWC46_RS21520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CWC46_RS21525	COG3842	ATPase activity
CWC46_RS21540	COG0438	transferase activity, transferring glycosyl groups
CWC46_RS21550	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CWC46_RS21565	COG2963	transposase activity
CWC46_RS21575	COG0463	Glycosyl transferase, family 2
CWC46_RS21585	COG4372	Transposase
CWC46_RS21605	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CWC46_RS21620	COG0463	Glycosyl transferase, family 2
CWC46_RS21690	COG1733	regulation of RNA biosynthetic process
CWC46_RS21695	COG1278	Cold shock
CWC46_RS21705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CWC46_RS21715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWC46_RS21720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWC46_RS21725	COG4974	Belongs to the 'phage' integrase family
CWC46_RS21730	COG1414	Transcriptional regulator
CWC46_RS21740	COG2271	Major facilitator Superfamily
CWC46_RS21750	COG0477	Major facilitator Superfamily
CWC46_RS21755	COG0716	FMN binding
CWC46_RS21760	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CWC46_RS21770	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CWC46_RS21775	COG0354	folic acid binding
CWC46_RS21780	COG1272	protein, Hemolysin III
CWC46_RS21790	COG1715	Restriction endonuclease
CWC46_RS21795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWC46_RS21795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWC46_RS21800	COG0509	glycine decarboxylation via glycine cleavage system
CWC46_RS21805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CWC46_RS21815	COG1454	alcohol dehydrogenase
CWC46_RS21835	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS21840	COG1177	transmembrane transport
CWC46_RS21845	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWC46_RS21850	COG3842	ATPase activity
CWC46_RS21855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CWC46_RS21865	COG0583	DNA-binding transcription factor activity
CWC46_RS21890	COG0667	Aldo Keto reductase
CWC46_RS21895	COG2813	Specifically methylates the guanine in position
CWC46_RS21900	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CWC46_RS21910	COG0813	purine-nucleoside phosphorylase activity
CWC46_RS21915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CWC46_RS21920	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CWC46_RS21925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWC46_RS21930	COG1070	Carbohydrate kinase
CWC46_RS21935	COG2390	Transcriptional regulator
CWC46_RS21945	COG1129	ABC transporter
CWC46_RS21955	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC46_RS21965	COG1830	Aldolase
CWC46_RS21985	COG2827	Endonuclease containing a URI domain
CWC46_RS21990	COG3153	acetyltransferase
CWC46_RS21995	COG3154	lipid carrier protein
CWC46_RS22000	COG0826	peptidase U32
CWC46_RS22005	COG0826	peptidase U32
CWC46_RS22010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWC46_RS22015	COG0513	Belongs to the DEAD box helicase family
CWC46_RS22025	COG1185	polyribonucleotide nucleotidyltransferase activity
CWC46_RS22030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CWC46_RS22035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWC46_RS22040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWC46_RS22045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWC46_RS22050	COG0195	Participates in both transcription termination and antitermination
CWC46_RS22080	COG1012	belongs to the aldehyde dehydrogenase family
CWC46_RS22110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWC46_RS22115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWC46_RS22120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CWC46_RS22130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CWC46_RS22135	COG1534	Rna-binding protein
CWC46_RS22140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWC46_RS22145	COG2027	D-alanyl-D-alanine carboxypeptidase
CWC46_RS22150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWC46_RS22155	COG0697	spore germination
CWC46_RS22165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWC46_RS22170	COG0142	geranyltranstransferase activity
CWC46_RS22185	COG3423	Transcriptional regulator
CWC46_RS22190	COG0039	L-malate dehydrogenase activity
CWC46_RS22195	COG1438	arginine binding
CWC46_RS22200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWC46_RS22205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CWC46_RS22210	COG0358	DNA primase activity
CWC46_RS22215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWC46_RS22220	COG3663	DNA glycosylase
CWC46_RS22240	COG3678	ATP-independent chaperone mediated protein folding
CWC46_RS22255	COG2813	Specifically methylates the guanine in position
CWC46_RS22260	COG0673	inositol 2-dehydrogenase activity
CWC46_RS22265	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CWC46_RS22275	COG2721	sulfolactate sulfo-lyase activity
CWC46_RS22280	COG0246	Mannitol dehydrogenase
CWC46_RS22285	COG1904	glucuronate isomerase
CWC46_RS22290	COG2271	Major facilitator Superfamily
CWC46_RS22300	COG0586	Pfam SNARE associated Golgi protein
CWC46_RS22310	COG4575	ribosome binding
CWC46_RS22315	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CWC46_RS22325	COG2259	Doxx family
CWC46_RS22330	COG0435	Glutathione S-transferase
CWC46_RS22335	COG0583	DNA-binding transcription factor activity
CWC46_RS22340	COG1741	Belongs to the pirin family
CWC46_RS22345	COG0735	belongs to the Fur family
CWC46_RS22350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWC46_RS22355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CWC46_RS22360	COG2937	Belongs to the GPAT DAPAT family
CWC46_RS22365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CWC46_RS22370	COG3161	chorismate lyase activity
CWC46_RS22375	COG0459	protein refolding
CWC46_RS22380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWC46_RS22395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CWC46_RS22400	COG1324	tolerance protein
CWC46_RS22405	COG4232	protein-disulfide reductase activity
CWC46_RS22410	COG1309	transcriptional regulator
CWC46_RS22440	COG0596	Alpha beta hydrolase
CWC46_RS22440	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWC46_RS22445	COG0022	dehydrogenase e1 component
CWC46_RS22450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CWC46_RS22455	COG3199	ATP-NAD kinase
CWC46_RS22460	COG3284	Transcriptional regulator
CWC46_RS22465	COG1648	precorrin-2 dehydrogenase activity
CWC46_RS22465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWC46_RS22490	COG1473	amidohydrolase
CWC46_RS22530	COG0840	transmembrane signaling receptor activity
CWC46_RS22540	COG0156	8-amino-7-oxononanoate synthase activity
CWC46_RS22545	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CWC46_RS22555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CWC46_RS22560	COG0084	hydrolase, TatD family'
CWC46_RS22565	COG2823	Periplasmic or secreted lipoprotein
CWC46_RS22570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CWC46_RS22575	COG3726	membrane protein affecting hemolysin expression
CWC46_RS22580	COG0560	Phosphoserine phosphatase
CWC46_RS22595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWC46_RS22605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CWC46_RS22615	COG0006	proline dipeptidase activity
CWC46_RS22620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWC46_RS22625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWC46_RS22635	COG1917	Cupin 2, conserved barrel domain protein
CWC46_RS22635	COG4977	sequence-specific DNA binding
CWC46_RS22640	COG1917	Cupin 2, conserved barrel domain protein
CWC46_RS22640	COG2169	Transcriptional regulator
CWC46_RS22645	COG1070	Carbohydrate kinase
CWC46_RS22650	COG4806	L-rhamnose isomerase
CWC46_RS22655	COG0235	Class ii aldolase
CWC46_RS22660	COG3254	rhamnose metabolic process
CWC46_RS22665	COG0840	transmembrane signaling receptor activity
CWC46_RS22670	COG1124	(ABC) transporter
CWC46_RS22675	COG0444	Belongs to the ABC transporter superfamily
CWC46_RS22680	COG1414	Transcriptional regulator
CWC46_RS22690	COG2731	YhcH YjgK YiaL family protein
CWC46_RS22700	COG1070	Carbohydrate kinase
CWC46_RS22705	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CWC46_RS22710	COG3623	hexulose-6-phosphate isomerase
CWC46_RS22715	COG0235	Class ii aldolase
CWC46_RS22720	COG1418	mRNA catabolic process
CWC46_RS22730	COG1605	Chorismate mutase
CWC46_RS22750	COG0583	DNA-binding transcription factor activity
CWC46_RS22870	COG3706	GGDEF domain