locus-tag	class	description
EGY12_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGY12_RS00280	COG1609	Transcriptional regulator
EGY12_RS00285	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EGY12_RS00290	COG0622	Phosphoesterase
EGY12_RS00295	COG0625	glutathione transferase activity
EGY12_RS00300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EGY12_RS00305	COG1090	epimerase
EGY12_RS00310	COG4598	ABC transporter
EGY12_RS00320	COG4215	(ABC) transporter
EGY12_RS00325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS00330	COG0163	prenyltransferase activity
EGY12_RS00335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EGY12_RS00340	COG1286	toxin biosynthetic process
EGY12_RS00345	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EGY12_RS00350	COG0285	dihydrofolate synthase activity
EGY12_RS00355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EGY12_RS00360	COG0586	Pfam SNARE associated Golgi protein
EGY12_RS00370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EGY12_RS00375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGY12_RS00385	COG0697	spore germination
EGY12_RS00390	COG0642	Histidine kinase
EGY12_RS00425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY12_RS00430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY12_RS00470	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGY12_RS00475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EGY12_RS00490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGY12_RS00495	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EGY12_RS00495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY12_RS00505	COG3101	peptidyl-lysine hydroxylation
EGY12_RS00510	COG0730	response to heat
EGY12_RS00515	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EGY12_RS00520	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EGY12_RS00525	COG2890	protein-(glutamine-N5) methyltransferase activity
EGY12_RS00530	COG2840	Smr protein MutS2
EGY12_RS00535	COG2062	phosphohistidine phosphatase, SixA
EGY12_RS00540	COG1024	Enoyl-CoA hydratase
EGY12_RS00540	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGY12_RS00545	COG0183	Belongs to the thiolase family
EGY12_RS00550	COG3691	Protein conserved in bacteria
EGY12_RS00565	COG3088	subunit of a heme lyase
EGY12_RS00565	COG4235	cytochrome complex assembly
EGY12_RS00570	COG4235	cytochrome complex assembly
EGY12_RS00570	COG3088	subunit of a heme lyase
EGY12_RS00575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY12_RS00580	COG1138	Cytochrome C-type biogenesis protein
EGY12_RS00585	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EGY12_RS00590	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGY12_RS00595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGY12_RS00600	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGY12_RS00610	COG2116	formate transmembrane transporter activity
EGY12_RS00625	COG2207	Transcriptional regulator
EGY12_RS00625	COG3708	Transcriptional regulator
EGY12_RS00640	COG2197	response regulator
EGY12_RS00650	COG0583	DNA-binding transcription factor activity
EGY12_RS00660	COG0697	spore germination
EGY12_RS00675	COG2951	lytic endotransglycosylase activity
EGY12_RS00690	COG1215	transferase activity, transferring glycosyl groups
EGY12_RS00695	COG1649	PFAM Uncharacterised BCR, COG1649
EGY12_RS00695	COG0726	polysaccharide deacetylase
EGY12_RS00700	COG0457	Tetratricopeptide repeat
EGY12_RS00705	COG1598	PFAM Uncharacterised protein family UPF0150
EGY12_RS00725	COG3038	cytochrome b561
EGY12_RS00730	COG0436	Aminotransferase
EGY12_RS00745	COG3275	phosphorelay sensor kinase activity
EGY12_RS00750	COG3279	Response regulator of the LytR AlgR family
EGY12_RS00760	COG2223	nitrite transmembrane transporter activity
EGY12_RS00775	COG1794	racemase activity, acting on amino acids and derivatives
EGY12_RS00790	COG3961	Belongs to the TPP enzyme family
EGY12_RS00795	COG0667	Aldo Keto reductase
EGY12_RS00810	COG1914	H( )-stimulated, divalent metal cation uptake system
EGY12_RS00815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EGY12_RS00830	COG2116	formate transmembrane transporter activity
EGY12_RS00835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGY12_RS00870	COG4592	Periplasmic binding protein
EGY12_RS00875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY12_RS00880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY12_RS00885	COG1120	ATPase activity
EGY12_RS00890	COG0747	negative chemotaxis
EGY12_RS00910	COG4302	ethanolamine ammonia-lyase activity
EGY12_RS00915	COG4303	Ethanolamine ammonia lyase large subunit
EGY12_RS00930	COG0583	DNA-binding transcription factor activity
EGY12_RS00935	COG0385	Bile acid
EGY12_RS00940	COG3530	Putative quorum-sensing-regulated virulence factor
EGY12_RS00945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGY12_RS00950	COG3115	cell septum assembly
EGY12_RS00955	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EGY12_RS00965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY12_RS00970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGY12_RS00980	COG2205	protein histidine kinase activity
EGY12_RS00985	COG0745	RESPONSE REGULATOR receiver
EGY12_RS00990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EGY12_RS01000	COG4208	sulfate ABC transporter
EGY12_RS01005	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGY12_RS01015	COG2837	iron assimilation
EGY12_RS01030	COG3111	PFAM Bacterial OB fold (BOF) protein
EGY12_RS01035	COG0456	acetyltransferase
EGY12_RS01045	COG0408	coproporphyrinogen oxidase activity
EGY12_RS01050	COG1671	Belongs to the UPF0178 family
EGY12_RS01060	COG1770	oligopeptidase
EGY12_RS01075	COG0833	amino acid
EGY12_RS01080	COG2040	homocysteine
EGY12_RS01085	COG0281	malic enzyme
EGY12_RS01085	COG0280	phosphate acetyltransferase
EGY12_RS01110	COG0583	DNA-binding transcription factor activity
EGY12_RS01115	COG3397	chitin binding
EGY12_RS01120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EGY12_RS01125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EGY12_RS01130	COG0494	nUDIX hydrolase
EGY12_RS01135	COG3850	Histidine kinase
EGY12_RS01140	COG2197	response regulator
EGY12_RS01150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY12_RS01160	COG0456	acetyltransferase
EGY12_RS01165	COG0454	-acetyltransferase
EGY12_RS01175	COG1393	Belongs to the ArsC family
EGY12_RS01180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGY12_RS01185	COG1876	peptidase activity
EGY12_RS01195	COG0400	carboxylic ester hydrolase activity
EGY12_RS01205	COG2321	neutral zinc metallopeptidase
EGY12_RS01210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGY12_RS01215	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EGY12_RS01220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY12_RS01225	COG2716	regulation of RNA biosynthetic process
EGY12_RS01230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGY12_RS01235	COG0628	permease
EGY12_RS01270	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGY12_RS01290	COG4783	chaperone-mediated protein folding
EGY12_RS01295	COG1393	Belongs to the ArsC family
EGY12_RS01310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGY12_RS01320	COG2261	transglycosylase associated protein
EGY12_RS01325	COG2233	PERMEase
EGY12_RS01330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EGY12_RS01335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGY12_RS01340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EGY12_RS01345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY12_RS01360	COG3210	domain, Protein
EGY12_RS01385	COG0573	inorganic phosphate transmembrane transporter activity
EGY12_RS01390	COG0573	inorganic phosphate transmembrane transporter activity
EGY12_RS01395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EGY12_RS01410	COG2239	Acts as a magnesium transporter
EGY12_RS01425	COG0443	Heat shock 70 kDa protein
EGY12_RS01440	COG0667	Aldo Keto reductase
EGY12_RS01450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY12_RS01455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY12_RS01460	COG2814	Major facilitator Superfamily
EGY12_RS01465	COG2205	protein histidine kinase activity
EGY12_RS01470	COG0745	RESPONSE REGULATOR receiver
EGY12_RS01485	COG3422	double-strand break repair
EGY12_RS01490	COG0826	peptidase U32
EGY12_RS01495	COG1597	lipid kinase activity
EGY12_RS01500	COG4948	Mandelate Racemase Muconate Lactonizing
EGY12_RS01505	COG1063	alcohol dehydrogenase
EGY12_RS01510	COG2271	Major facilitator Superfamily
EGY12_RS01515	COG0246	Mannitol dehydrogenase
EGY12_RS01525	COG1802	Transcriptional regulator
EGY12_RS01530	COG1830	Aldolase
EGY12_RS01535	COG3730	PTS system glucitol sorbitol-specific
EGY12_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS01555	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY12_RS01560	COG1349	DNA-binding transcription factor activity
EGY12_RS01575	COG0351	phosphomethylpyrimidine kinase
EGY12_RS01580	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EGY12_RS01600	COG1289	transmembrane transporter activity
EGY12_RS01610	COG2814	Major facilitator Superfamily
EGY12_RS01620	COG1187	pseudouridine synthase activity
EGY12_RS01630	COG2207	Transcriptional regulator
EGY12_RS01650	COG0784	Response regulator, receiver
EGY12_RS01650	COG2205	protein histidine kinase activity
EGY12_RS01650	COG2198	Histidine kinase
EGY12_RS01665	COG0519	Catalyzes the synthesis of GMP from XMP
EGY12_RS01665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGY12_RS01670	COG0517	IMP dehydrogenase activity
EGY12_RS01670	COG0516	GMP reductase activity
EGY12_RS01680	COG1570	exodeoxyribonuclease VII activity
EGY12_RS01690	COG2271	Major facilitator Superfamily
EGY12_RS01695	COG1609	Transcriptional regulator
EGY12_RS01710	COG1645	bacterial-type flagellum-dependent swarming motility
EGY12_RS01720	COG1160	GTP binding
EGY12_RS01725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY12_RS01730	COG2976	Protein conserved in bacteria
EGY12_RS01735	COG0124	histidyl-tRNA synthetase
EGY12_RS01740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EGY12_RS01745	COG1426	Protein conserved in bacteria
EGY12_RS01755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGY12_RS01760	COG0105	UTP biosynthetic process
EGY12_RS01770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EGY12_RS01775	COG2975	iron-sulfur cluster assembly
EGY12_RS01780	COG0633	Ferredoxin
EGY12_RS01785	COG0443	Heat shock 70 kDa protein
EGY12_RS01790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EGY12_RS01795	COG0316	Belongs to the HesB IscA family
EGY12_RS01800	COG0822	iron-sulfur transferase activity
EGY12_RS01805	COG1104	cysteine desulfurase activity
EGY12_RS01810	COG1959	2 iron, 2 sulfur cluster binding
EGY12_RS01825	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EGY12_RS01830	COG3683	transport system, periplasmic component
EGY12_RS01835	COG3711	transcriptional antiterminator
EGY12_RS01840	COG2814	Major facilitator Superfamily
EGY12_RS01845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGY12_RS01850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY12_RS01850	COG1017	nitric oxide dioxygenase activity
EGY12_RS01860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EGY12_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS01870	COG1177	transmembrane transport
EGY12_RS01875	COG1176	ABC-type spermidine putrescine transport system, permease component I
EGY12_RS01880	COG3842	ATPase activity
EGY12_RS01885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EGY12_RS01895	COG0583	DNA-binding transcription factor activity
EGY12_RS01900	COG0347	Belongs to the P(II) protein family
EGY12_RS01905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY12_RS01905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGY12_RS01910	COG2204	response regulator
EGY12_RS01915	COG3170	Tfp pilus assembly protein FimV
EGY12_RS01920	COG2205	protein histidine kinase activity
EGY12_RS01930	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EGY12_RS01945	COG0560	Phosphoserine phosphatase
EGY12_RS01950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS01950	COG1263	PTS System
EGY12_RS01955	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EGY12_RS01960	COG1737	Transcriptional regulator
EGY12_RS01965	COG2194	sulfuric ester hydrolase activity
EGY12_RS01970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGY12_RS01975	COG0736	holo-[acyl-carrier-protein] synthase activity
EGY12_RS01980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EGY12_RS01985	COG1381	Involved in DNA repair and RecF pathway recombination
EGY12_RS01990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGY12_RS01995	COG0571	ribonuclease III activity
EGY12_RS02005	COG0481	GTPase activity
EGY12_RS02015	COG3086	response to oxidative stress
EGY12_RS02020	COG3026	antisigma factor binding
EGY12_RS02035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EGY12_RS02040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EGY12_RS02045	COG0513	Belongs to the DEAD box helicase family
EGY12_RS02065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EGY12_RS02070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EGY12_RS02075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EGY12_RS02080	COG0497	DNA recombination
EGY12_RS02085	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY12_RS02090	COG2914	Belongs to the UPF0125 (RnfH) family
EGY12_RS02095	COG2867	negative regulation of translational initiation
EGY12_RS02100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EGY12_RS02110	COG1566	PFAM secretion protein HlyD family protein
EGY12_RS02125	COG0583	DNA-binding transcription factor activity
EGY12_RS02155	COG3182	Iron-regulated membrane protein
EGY12_RS02170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EGY12_RS02195	COG2388	GCN5-related N-acetyl-transferase
EGY12_RS02200	COG3592	Divergent 4Fe-4S mono-cluster
EGY12_RS02205	COG2259	Doxx family
EGY12_RS02275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EGY12_RS02280	COG2840	Smr protein MutS2
EGY12_RS02300	COG0477	Major facilitator Superfamily
EGY12_RS02310	COG0477	Major facilitator Superfamily
EGY12_RS02325	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EGY12_RS02330	COG4575	ribosome binding
EGY12_RS02340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGY12_RS02345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EGY12_RS02350	COG1780	Probably involved in ribonucleotide reductase function
EGY12_RS02370	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS02380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EGY12_RS02385	COG1752	Esterase of the alpha-beta hydrolase superfamily
EGY12_RS02390	COG3493	citrate carrier protein
EGY12_RS02410	COG4176	ABC-type proline glycine betaine transport system permease component
EGY12_RS02415	COG2113	Glycine betaine
EGY12_RS02420	COG0583	DNA-binding transcription factor activity
EGY12_RS02425	COG2814	Major facilitator Superfamily
EGY12_RS02430	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EGY12_RS02440	COG1846	Transcriptional regulator
EGY12_RS02450	COG1566	PFAM secretion protein HlyD family protein
EGY12_RS02455	COG2814	Major facilitator Superfamily
EGY12_RS02460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGY12_RS02465	COG3118	belongs to the thioredoxin family
EGY12_RS02470	COG3148	PFAM DTW domain containing protein
EGY12_RS02475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY12_RS02475	COG1042	CoA-binding domain protein
EGY12_RS02475	COG0045	succinate-CoA ligase (ADP-forming) activity
EGY12_RS02480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGY12_RS02485	COG0477	Major facilitator Superfamily
EGY12_RS02515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EGY12_RS02525	COG2011	ABC-type metal ion transport system permease component
EGY12_RS02530	COG1464	Belongs to the NlpA lipoprotein family
EGY12_RS02540	COG1720	tRNA m6t6A37 methyltransferase activity
EGY12_RS02545	COG0442	prolyl-tRNA aminoacylation
EGY12_RS02550	COG3015	lipoprotein NlpE involved in copper resistance
EGY12_RS02555	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EGY12_RS02570	COG4568	rho-dependent transcription termination
EGY12_RS02580	COG0037	tRNA processing
EGY12_RS02585	COG3104	oligopeptide transport
EGY12_RS02595	COG0531	amino acid
EGY12_RS02600	COG3710	Transcriptional regulator
EGY12_RS02605	COG0346	lactoylglutathione lyase activity
EGY12_RS02610	COG1982	Orn Lys Arg decarboxylase major
EGY12_RS02615	COG0825	malonyl-CoA metabolic process
EGY12_RS02620	COG0587	DNA-directed DNA polymerase activity
EGY12_RS02625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGY12_RS02630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY12_RS02635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY12_RS02640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGY12_RS02645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY12_RS02650	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EGY12_RS02655	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY12_RS02660	COG0750	zinc metalloprotease
EGY12_RS02665	COG0575	Belongs to the CDS family
EGY12_RS02670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EGY12_RS02675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EGY12_RS02680	COG0233	cytoplasmic translational termination
EGY12_RS02685	COG0528	UMP kinase activity
EGY12_RS02695	COG0052	Belongs to the universal ribosomal protein uS2 family
EGY12_RS02705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EGY12_RS02725	COG0564	pseudouridine synthase activity
EGY12_RS02730	COG4953	penicillin-binding protein 1C
EGY12_RS02735	COG2373	Large extracellular alpha-helical protein
EGY12_RS02740	COG3098	single-species biofilm formation
EGY12_RS02745	COG2814	Major facilitator Superfamily
EGY12_RS02760	COG1611	Belongs to the LOG family
EGY12_RS02765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGY12_RS02770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EGY12_RS02775	COG2363	Small membrane protein
EGY12_RS02780	COG0583	DNA-binding transcription factor activity
EGY12_RS02790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGY12_RS02795	COG2166	iron-sulfur cluster assembly
EGY12_RS02800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGY12_RS02805	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EGY12_RS02825	COG0860	N-Acetylmuramoyl-L-alanine amidase
EGY12_RS02830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EGY12_RS02830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGY12_RS02835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGY12_RS02840	COG1074	ATP-dependent DNA helicase activity
EGY12_RS02845	COG1025	Belongs to the peptidase M16 family
EGY12_RS02850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EGY12_RS02870	COG2165	general secretion pathway protein
EGY12_RS02875	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EGY12_RS02880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EGY12_RS02890	COG0494	nUDIX hydrolase
EGY12_RS02895	COG3066	DNA modification
EGY12_RS02900	COG0861	Integral membrane protein TerC family
EGY12_RS02910	COG0667	Aldo Keto reductase
EGY12_RS02915	COG0477	Major facilitator Superfamily
EGY12_RS02920	COG0204	Acyl-transferase
EGY12_RS02920	COG0318	PFAM AMP-dependent synthetase and ligase
EGY12_RS02930	COG1609	Transcriptional regulator
EGY12_RS02940	COG0583	DNA-binding transcription factor activity
EGY12_RS02945	COG0583	DNA-binding transcription factor activity
EGY12_RS02965	COG4178	(ABC) transporter
EGY12_RS02975	COG3716	PTS system mannose fructose sorbose family IID component
EGY12_RS02980	COG3715	PTS system
EGY12_RS02985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS02995	COG1349	DNA-binding transcription factor activity
EGY12_RS03000	COG2807	transmembrane transport
EGY12_RS03010	COG4615	Cyclic peptide transporter
EGY12_RS03015	COG0583	DNA-binding transcription factor activity
EGY12_RS03020	COG1620	l-lactate permease
EGY12_RS03025	COG1304	FMN binding
EGY12_RS03035	COG2814	Major facilitator Superfamily
EGY12_RS03045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGY12_RS03050	COG1309	transcriptional regulator
EGY12_RS03055	COG5265	(ABC) transporter
EGY12_RS03060	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EGY12_RS03065	COG4942	peptidase
EGY12_RS03070	COG3247	response to pH
EGY12_RS03080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGY12_RS03085	COG1609	Transcriptional regulator
EGY12_RS03105	COG2731	YhcH YjgK YiaL family protein
EGY12_RS03110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY12_RS03115	COG2271	Major facilitator Superfamily
EGY12_RS03125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EGY12_RS03135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EGY12_RS03140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGY12_RS03145	COG4974	Belongs to the 'phage' integrase family
EGY12_RS03150	COG0716	FMN binding
EGY12_RS03160	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EGY12_RS03165	COG0354	folic acid binding
EGY12_RS03175	COG1272	protein, Hemolysin III
EGY12_RS03185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY12_RS03190	COG1940	carbohydrate kinase activity
EGY12_RS03195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EGY12_RS03200	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS03205	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS03210	COG1129	ABC transporter
EGY12_RS03220	COG1349	DNA-binding transcription factor activity
EGY12_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS03265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGY12_RS03265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGY12_RS03270	COG0509	glycine decarboxylation via glycine cleavage system
EGY12_RS03275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EGY12_RS03280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY12_RS03285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY12_RS03290	COG0006	proline dipeptidase activity
EGY12_RS03295	COG3079	Belongs to the UPF0149 family
EGY12_RS03300	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EGY12_RS03310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGY12_RS03315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGY12_RS03325	COG0583	DNA-binding transcription factor activity
EGY12_RS03335	COG1279	arginine transmembrane transporter activity
EGY12_RS03340	COG1414	Transcriptional regulator
EGY12_RS03345	COG1129	ABC transporter
EGY12_RS03350	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS03370	COG2731	YhcH YjgK YiaL family protein
EGY12_RS03380	COG1070	Carbohydrate kinase
EGY12_RS03385	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EGY12_RS03390	COG3623	hexulose-6-phosphate isomerase
EGY12_RS03395	COG0235	Class ii aldolase
EGY12_RS03400	COG0564	pseudouridine synthase activity
EGY12_RS03405	COG3122	Protein conserved in bacteria
EGY12_RS03420	COG2271	Major facilitator Superfamily
EGY12_RS03440	COG0191	fructose-bisphosphate aldolase activity
EGY12_RS03445	COG0126	phosphoglycerate kinase activity
EGY12_RS03450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EGY12_RS03455	COG0583	DNA-binding transcription factor activity
EGY12_RS03460	COG0473	3-isopropylmalate dehydrogenase activity
EGY12_RS03465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGY12_RS03470	COG4638	Rieske (2fe-2S)
EGY12_RS03480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY12_RS03485	COG3842	ATPase activity
EGY12_RS03490	COG1175	transmembrane transport
EGY12_RS03505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY12_RS03515	COG1114	Component of the transport system for branched-chain amino acids
EGY12_RS03520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EGY12_RS03525	COG0501	Belongs to the peptidase M48B family
EGY12_RS03540	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
EGY12_RS03545	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS03550	COG2267	carboxylic ester hydrolase activity
EGY12_RS03575	COG1414	Transcriptional regulator
EGY12_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS03595	COG2146	nitrite reductase [NAD(P)H] activity
EGY12_RS03600	COG2271	Major facilitator Superfamily
EGY12_RS03610	COG0010	Belongs to the arginase family
EGY12_RS03615	COG1166	arginine decarboxylase activity
EGY12_RS03630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EGY12_RS03645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EGY12_RS03650	COG1120	ATPase activity
EGY12_RS03655	COG4774	siderophore transport
EGY12_RS03660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGY12_RS03665	COG1643	Atp-dependent helicase
EGY12_RS03670	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EGY12_RS03675	COG1489	DNA binding
EGY12_RS03690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGY12_RS03695	COG0617	tRNA 3'-terminal CCA addition
EGY12_RS03700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EGY12_RS03710	COG2149	membrane
EGY12_RS03715	COG0642	Histidine kinase
EGY12_RS03725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EGY12_RS03730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EGY12_RS03735	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EGY12_RS03740	COG0726	polysaccharide deacetylase
EGY12_RS03745	COG0842	Transport permease protein
EGY12_RS03750	COG1131	(ABC) transporter
EGY12_RS03755	COG0288	reversible hydration of carbon dioxide
EGY12_RS03775	COG2132	Multicopper oxidase
EGY12_RS03785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EGY12_RS03790	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EGY12_RS03795	COG3112	Uncharacterised protein family (UPF0231)
EGY12_RS03805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY12_RS03810	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGY12_RS03815	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EGY12_RS03820	COG2186	Transcriptional regulator
EGY12_RS03825	COG1113	amino acid transport
EGY12_RS03830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY12_RS03830	COG2010	Cytochrome c
EGY12_RS03840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY12_RS03840	COG2010	Cytochrome c
EGY12_RS03850	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EGY12_RS03855	COG3708	Transcriptional regulator
EGY12_RS03855	COG2207	Transcriptional regulator
EGY12_RS03865	COG3091	SprT-like family
EGY12_RS03870	COG2356	endonuclease I
EGY12_RS03875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGY12_RS03880	COG0189	ligase activity
EGY12_RS03885	COG1678	Uncharacterized ACR, COG1678
EGY12_RS03890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EGY12_RS03895	COG2805	Type II/IV secretion system protein
EGY12_RS03900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGY12_RS03905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EGY12_RS03910	COG0762	integral membrane protein
EGY12_RS03915	COG1872	DUF167
EGY12_RS03925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGY12_RS03940	COG2066	Belongs to the glutaminase family
EGY12_RS03945	COG3171	Protein conserved in bacteria
EGY12_RS03950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGY12_RS03960	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EGY12_RS03965	COG0741	lytic transglycosylase activity
EGY12_RS03970	COG1982	Orn Lys Arg decarboxylase major
EGY12_RS03990	COG2819	hydrolase of the alpha beta superfamily
EGY12_RS03995	COG0454	-acetyltransferase
EGY12_RS04025	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGY12_RS04025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGY12_RS04060	COG0848	biopolymer transport protein
EGY12_RS04075	COG0586	Pfam SNARE associated Golgi protein
EGY12_RS04080	COG0583	DNA-binding transcription factor activity
EGY12_RS04085	COG3321	synthase
EGY12_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS04085	COG0604	alcohol dehydrogenase
EGY12_RS04090	COG2207	Transcriptional regulator
EGY12_RS04095	COG1979	alcohol dehydrogenase
EGY12_RS04100	COG0656	L-ascorbic acid biosynthetic process
EGY12_RS04105	COG0741	lytic transglycosylase activity
EGY12_RS04115	COG2186	Transcriptional regulator
EGY12_RS04125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY12_RS04130	COG2211	Major facilitator Superfamily
EGY12_RS04135	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EGY12_RS04140	COG0583	DNA-binding transcription factor activity
EGY12_RS04145	COG2132	Multicopper oxidase
EGY12_RS04160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EGY12_RS04165	COG2249	NAD(P)H dehydrogenase (quinone) activity
EGY12_RS04170	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EGY12_RS04175	COG0583	DNA-binding transcription factor activity
EGY12_RS04180	COG0187	DNA topoisomerase II activity
EGY12_RS04185	COG3150	esterase
EGY12_RS04190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EGY12_RS04195	COG3151	Protein conserved in bacteria
EGY12_RS04200	COG0494	nUDIX hydrolase
EGY12_RS04205	COG1538	Outer membrane efflux protein
EGY12_RS04215	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EGY12_RS04215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY12_RS04215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGY12_RS04220	COG1461	Dihydroxyacetone kinase
EGY12_RS04225	COG2376	Dihydroxyacetone kinase
EGY12_RS04235	COG5463	Belongs to the UPF0441 family
EGY12_RS04240	COG0754	glutathionylspermidine amidase activity
EGY12_RS04245	COG3384	dioxygenase
EGY12_RS04255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGY12_RS04265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGY12_RS04265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGY12_RS04270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EGY12_RS04275	COG3025	triphosphatase activity
EGY12_RS04280	COG4991	sh3 domain protein
EGY12_RS04285	COG0617	tRNA 3'-terminal CCA addition
EGY12_RS04290	COG1968	undecaprenyl-diphosphatase activity
EGY12_RS04295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EGY12_RS04300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGY12_RS04305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EGY12_RS04310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EGY12_RS04315	COG0358	DNA primase activity
EGY12_RS04335	COG2378	regulation of single-species biofilm formation
EGY12_RS04350	COG0625	glutathione transferase activity
EGY12_RS04360	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS04365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EGY12_RS04375	COG0488	(ABC) transporter
EGY12_RS04380	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY12_RS04380	COG1902	pentaerythritol trinitrate reductase activity
EGY12_RS04385	COG2813	Specifically methylates the guanine in position
EGY12_RS04390	COG1451	nucleotide metabolic process
EGY12_RS04395	COG0673	inositol 2-dehydrogenase activity
EGY12_RS04400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGY12_RS04400	COG0519	Catalyzes the synthesis of GMP from XMP
EGY12_RS04405	COG0861	Integral membrane protein TerC family
EGY12_RS04410	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EGY12_RS04415	COG2721	sulfolactate sulfo-lyase activity
EGY12_RS04420	COG1904	glucuronate isomerase
EGY12_RS04425	COG2271	Major facilitator Superfamily
EGY12_RS04440	COG0586	Pfam SNARE associated Golgi protein
EGY12_RS04445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGY12_RS04455	COG4575	ribosome binding
EGY12_RS04460	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
EGY12_RS04470	COG2259	Doxx family
EGY12_RS04475	COG0435	Glutathione S-transferase
EGY12_RS04480	COG0583	DNA-binding transcription factor activity
EGY12_RS04485	COG1741	Belongs to the pirin family
EGY12_RS04495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EGY12_RS04500	COG3107	peptidoglycan biosynthetic process
EGY12_RS04505	COG0792	nuclease activity
EGY12_RS04510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EGY12_RS04515	COG2823	Periplasmic or secreted lipoprotein
EGY12_RS04525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EGY12_RS04530	COG0784	Response regulator, receiver
EGY12_RS04530	COG2198	Histidine kinase
EGY12_RS04530	COG5002	protein histidine kinase activity
EGY12_RS04535	COG1242	4 iron, 4 sulfur cluster binding
EGY12_RS04540	COG0067	glutamate synthase
EGY12_RS04540	COG0070	glutamate synthase
EGY12_RS04540	COG0069	glutamate synthase activity
EGY12_RS04545	COG0493	'glutamate synthase
EGY12_RS04555	COG2969	positive regulation of protein catabolic process
EGY12_RS04560	COG0625	glutathione transferase activity
EGY12_RS04565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EGY12_RS04570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EGY12_RS04575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EGY12_RS04580	COG3105	Protein conserved in bacteria
EGY12_RS04585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGY12_RS04590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGY12_RS04595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGY12_RS04600	COG5007	Belongs to the BolA IbaG family
EGY12_RS04605	COG3113	response to antibiotic
EGY12_RS04610	COG2854	intermembrane phospholipid transfer
EGY12_RS04615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGY12_RS04620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGY12_RS04625	COG1127	ABC transporter
EGY12_RS04630	COG0530	calcium, potassium:sodium antiporter activity
EGY12_RS04635	COG0517	IMP dehydrogenase activity
EGY12_RS04635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EGY12_RS04640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EGY12_RS04645	COG3117	lipopolysaccharide transmembrane transporter activity
EGY12_RS04650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EGY12_RS04655	COG1137	ATPase activity
EGY12_RS04660	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EGY12_RS04675	COG1660	Displays ATPase and GTPase activities
EGY12_RS04680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY12_RS04685	COG4680	protein conserved in bacteria
EGY12_RS04690	COG5499	transcription regulator containing HTH domain
EGY12_RS04695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY12_RS04695	COG3711	transcriptional antiterminator
EGY12_RS04715	COG3964	amidohydrolase
EGY12_RS04745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGY12_RS04755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGY12_RS04765	COG2207	Transcriptional regulator
EGY12_RS04770	COG3783	Cytochrome b(562)
EGY12_RS04775	COG0312	modulator of DNA gyrase
EGY12_RS04780	COG3028	Belongs to the UPF0307 family
EGY12_RS04785	COG2732	(Barnase) inhibitor
EGY12_RS04795	COG1289	transmembrane transporter activity
EGY12_RS04800	COG1566	PFAM secretion protein HlyD family protein
EGY12_RS04810	COG0583	DNA-binding transcription factor activity
EGY12_RS04855	COG3188	usher protein
EGY12_RS04860	COG3121	Chaperone
EGY12_RS04870	COG3539	Fimbrial protein
EGY12_RS04895	COG2197	response regulator
EGY12_RS04910	COG2134	cdp-diacylglycerol pyrophosphatase
EGY12_RS04915	COG0312	modulator of DNA gyrase
EGY12_RS04920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY12_RS04925	COG3164	Protein of unknown function
EGY12_RS04930	COG1530	ribonuclease E activity
EGY12_RS04935	COG0424	maF-like protein
EGY12_RS04940	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EGY12_RS04945	COG1792	Involved in formation and maintenance of cell shape
EGY12_RS04950	COG1077	Cell shape determining protein MreB Mrl
EGY12_RS04955	COG2200	EAL domain
EGY12_RS04955	COG2199	diguanylate cyclase activity
EGY12_RS04960	COG0604	alcohol dehydrogenase
EGY12_RS04965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EGY12_RS04970	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EGY12_RS04975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EGY12_RS04980	COG0511	ligase activity, forming carbon-carbon bonds
EGY12_RS04985	COG0439	Biotin carboxylase
EGY12_RS04990	COG3924	membrane
EGY12_RS04995	COG4145	pantothenate transmembrane transporter activity
EGY12_RS05000	COG2264	protein methyltransferase activity
EGY12_RS05030	COG1560	Kdo2-lipid A biosynthetic process
EGY12_RS05035	COG0504	CTP synthase activity
EGY12_RS05040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY12_RS05040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY12_RS05050	COG1380	Effector of murein hydrolase LrgA
EGY12_RS05055	COG0583	DNA-binding transcription factor activity
EGY12_RS05060	COG0025	NhaP-type Na H and K H
EGY12_RS05065	COG2252	PERMEase
EGY12_RS05075	COG0625	glutathione transferase activity
EGY12_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS05105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EGY12_RS05110	COG3713	MltA-interacting MipA family protein
EGY12_RS05120	COG0110	maltose O-acetyltransferase activity
EGY12_RS05125	COG2315	Protein conserved in bacteria
EGY12_RS05130	COG0432	Pfam Uncharacterised protein family UPF0047
EGY12_RS05135	COG1448	Aminotransferase
EGY12_RS05140	COG1522	sequence-specific DNA binding
EGY12_RS05160	COG0604	alcohol dehydrogenase
EGY12_RS05170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGY12_RS05180	COG1595	DNA-templated transcription, initiation
EGY12_RS05190	COG0735	belongs to the Fur family
EGY12_RS05195	COG3237	CsbD-like
EGY12_RS05200	COG0534	Mate efflux family protein
EGY12_RS05205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EGY12_RS05210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EGY12_RS05215	COG2937	Belongs to the GPAT DAPAT family
EGY12_RS05220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EGY12_RS05225	COG3161	chorismate lyase activity
EGY12_RS05230	COG0477	Major facilitator Superfamily
EGY12_RS05235	COG1609	Transcriptional regulator
EGY12_RS05250	COG4580	involved in the transport of maltose and maltodextrins
EGY12_RS05260	COG0366	Alpha amylase catalytic
EGY12_RS05265	COG2182	Extracellular solute-binding protein
EGY12_RS05270	COG1175	transmembrane transport
EGY12_RS05275	COG3833	ABC-type maltose transport systems, permease component
EGY12_RS05280	COG3223	Belongs to the PsiE family
EGY12_RS05290	COG0166	Belongs to the GPI family
EGY12_RS05300	COG0527	aspartate kinase activity
EGY12_RS05320	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGY12_RS05335	COG0395	ABC-type sugar transport system, permease component
EGY12_RS05340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EGY12_RS05350	COG2188	Transcriptional regulator
EGY12_RS05355	COG0646	methionine synthase
EGY12_RS05355	COG1410	methionine synthase
EGY12_RS05360	COG1414	Transcriptional regulator
EGY12_RS05365	COG3265	gluconokinase activity
EGY12_RS05370	COG2610	gluconate transmembrane transporter activity
EGY12_RS05375	COG0129	dihydroxy-acid dehydratase activity
EGY12_RS05380	COG0800	Aldolase
EGY12_RS05385	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EGY12_RS05395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EGY12_RS05400	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EGY12_RS05435	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EGY12_RS05440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EGY12_RS05445	COG0009	L-threonylcarbamoyladenylate synthase
EGY12_RS05450	COG0551	DNA topoisomerase type I activity
EGY12_RS05455	COG2922	Belongs to the Smg family
EGY12_RS05460	COG0758	DNA mediated transformation
EGY12_RS05465	COG0242	peptide deformylase activity
EGY12_RS05470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGY12_RS05475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGY12_RS05475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGY12_RS05480	COG0569	domain protein
EGY12_RS05485	COG1970	mechanosensitive ion channel activity
EGY12_RS05490	COG3036	rescue of stalled ribosome
EGY12_RS05495	COG0789	Transcriptional regulator
EGY12_RS05505	COG0203	ribosomal protein L17
EGY12_RS05510	COG0202	RNA polymerase activity
EGY12_RS05515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EGY12_RS05520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EGY12_RS05525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EGY12_RS05530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGY12_RS05535	COG0201	protein transport
EGY12_RS05545	COG1841	ribosomal large subunit assembly
EGY12_RS05550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGY12_RS05555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EGY12_RS05560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EGY12_RS05600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EGY12_RS05605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EGY12_RS05615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EGY12_RS05625	COG0089	rRNA binding
EGY12_RS05630	COG0088	Forms part of the polypeptide exit tunnel
EGY12_RS05635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EGY12_RS05640	COG0051	transcription antitermination factor activity, RNA binding
EGY12_RS05655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGY12_RS05665	COG0049	tRNA binding
EGY12_RS05670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EGY12_RS05675	COG2168	tRNA wobble position uridine thiolation
EGY12_RS05680	COG2923	Belongs to the DsrF TusC family
EGY12_RS05685	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EGY12_RS05690	COG2964	Protein conserved in bacteria
EGY12_RS05695	COG0545	Peptidyl-prolyl cis-trans isomerase
EGY12_RS05700	COG2900	Belongs to the SlyX family
EGY12_RS05705	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EGY12_RS05710	COG1757	Na H antiporter
EGY12_RS05715	COG1609	Transcriptional regulator
EGY12_RS05720	COG1047	Peptidyl-prolyl cis-trans
EGY12_RS05725	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EGY12_RS05735	COG2249	NAD(P)H dehydrogenase (quinone) activity
EGY12_RS05740	COG0488	(ABC) transporter
EGY12_RS05745	COG2175	clavaminate synthase activity
EGY12_RS05750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY12_RS05760	COG4521	taurine ABC transporter
EGY12_RS05775	COG0429	hydrolase of the alpha beta-hydrolase fold
EGY12_RS05780	COG3089	Belongs to the UPF0270 family
EGY12_RS05785	COG3954	Phosphoribulokinase
EGY12_RS05790	COG1765	OsmC-like protein
EGY12_RS05795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGY12_RS05800	COG1289	transmembrane transporter activity
EGY12_RS05815	COG0433	COG0433 Predicted ATPase
EGY12_RS05825	COG3275	phosphorelay sensor kinase activity
EGY12_RS05830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EGY12_RS05840	COG1447	Phosphotransferase system cellobiose-specific component IIA
EGY12_RS05845	COG1486	melibiose metabolic process
EGY12_RS05850	COG1609	Transcriptional regulator
EGY12_RS05855	COG0738	Major facilitator superfamily
EGY12_RS05860	COG0402	S-adenosylhomocysteine deaminase activity
EGY12_RS05870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGY12_RS05880	COG2116	formate transmembrane transporter activity
EGY12_RS05885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGY12_RS05885	COG1648	precorrin-2 dehydrogenase activity
EGY12_RS05890	COG0180	Tryptophanyl-tRNA synthetase
EGY12_RS05895	COG0546	phosphoglycolate phosphatase activity
EGY12_RS05915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EGY12_RS05920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EGY12_RS05925	COG4796	Type ii and iii secretion system protein
EGY12_RS05950	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EGY12_RS05955	COG0494	nUDIX hydrolase
EGY12_RS05965	COG1011	Hydrolase
EGY12_RS05970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EGY12_RS05975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EGY12_RS06010	COG0484	heat shock protein binding
EGY12_RS06015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGY12_RS06020	COG2183	response to ionizing radiation
EGY12_RS06025	COG1918	ferrous iron import across plasma membrane
EGY12_RS06050	COG1040	competence protein
EGY12_RS06055	COG0316	Belongs to the HesB IscA family
EGY12_RS06055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EGY12_RS06060	COG1640	4-alpha-glucanotransferase
EGY12_RS06065	COG0058	SHG alpha-glucan phosphorylase activity
EGY12_RS06070	COG2909	trisaccharide binding
EGY12_RS06075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGY12_RS06080	COG0705	Rhomboid family
EGY12_RS06085	COG1349	DNA-binding transcription factor activity
EGY12_RS06090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EGY12_RS06095	COG0058	SHG alpha-glucan phosphorylase activity
EGY12_RS06100	COG0297	glycogen (starch) synthase activity
EGY12_RS06105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EGY12_RS06110	COG1523	belongs to the glycosyl hydrolase 13 family
EGY12_RS06115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EGY12_RS06120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EGY12_RS06125	COG2095	MarC family integral membrane protein
EGY12_RS06130	COG3265	gluconokinase activity
EGY12_RS06135	COG2610	gluconate transmembrane transporter activity
EGY12_RS06140	COG1609	Transcriptional regulator
EGY12_RS06145	COG2188	Transcriptional regulator
EGY12_RS06155	COG3457	Alanine racemase
EGY12_RS06160	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EGY12_RS06165	COG1735	metal-dependent hydrolase with the TIM-barrel fold
EGY12_RS06190	COG1741	Belongs to the pirin family
EGY12_RS06195	COG1247	-acetyltransferase
EGY12_RS06200	COG3191	aminopeptidase activity
EGY12_RS06205	COG1082	Xylose isomerase domain protein TIM barrel
EGY12_RS06210	COG1082	Xylose isomerase domain protein TIM barrel
EGY12_RS06215	COG0673	inositol 2-dehydrogenase activity
EGY12_RS06220	COG3962	Belongs to the TPP enzyme family
EGY12_RS06225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY12_RS06245	COG3718	enzyme involved in inositol metabolism
EGY12_RS06255	COG0477	Major facilitator Superfamily
EGY12_RS06255	COG2814	Major facilitator Superfamily
EGY12_RS06265	COG0390	transport system, permease component
EGY12_RS06270	COG4619	ABC transporter
EGY12_RS06300	COG3188	usher protein
EGY12_RS06310	COG3539	Fimbrial protein
EGY12_RS06325	COG2197	response regulator
EGY12_RS06335	COG0697	spore germination
EGY12_RS06365	COG2081	HI0933 family
EGY12_RS06370	COG0306	phosphate transporter
EGY12_RS06385	COG0583	DNA-binding transcription factor activity
EGY12_RS06390	COG0589	response to stress
EGY12_RS06405	COG1129	ABC transporter
EGY12_RS06410	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS06415	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS06430	COG0742	ribosomal rna small subunit methyltransferase
EGY12_RS06435	COG0339	signal peptide processing
EGY12_RS06450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EGY12_RS06455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY12_RS06465	COG2205	protein histidine kinase activity
EGY12_RS06465	COG0784	Response regulator, receiver
EGY12_RS06490	COG5441	Belongs to the UPF0261 family
EGY12_RS06495	COG5564	TIM-barrel signal transduction protein
EGY12_RS06500	COG3678	ATP-independent chaperone mediated protein folding
EGY12_RS06505	COG5001	Diguanylate cyclase
EGY12_RS06510	COG1024	Enoyl-CoA hydratase
EGY12_RS06515	COG1295	ribonuclease BN
EGY12_RS06520	COG0477	Major facilitator Superfamily
EGY12_RS06525	COG2134	cdp-diacylglycerol pyrophosphatase
EGY12_RS06530	COG2982	Protein involved in outer membrane biogenesis
EGY12_RS06535	COG2200	EAL domain
EGY12_RS06540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY12_RS06550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EGY12_RS06575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGY12_RS06580	COG0129	dihydroxy-acid dehydratase activity
EGY12_RS06585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EGY12_RS06590	COG3978	acetolactate synthase activity
EGY12_RS06605	COG2814	Major facilitator Superfamily
EGY12_RS06615	COG3085	chromosome segregation
EGY12_RS06620	COG0583	DNA-binding transcription factor activity
EGY12_RS06660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EGY12_RS06665	COG4206	TonB-dependent receptor
EGY12_RS06670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGY12_RS06685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY12_RS06695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EGY12_RS06695	COG0678	peroxiredoxin activity
EGY12_RS06700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY12_RS06715	COG0165	Argininosuccinate lyase
EGY12_RS06720	COG0137	argininosuccinate synthase activity
EGY12_RS06725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGY12_RS06740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EGY12_RS06745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EGY12_RS06750	COG0460	homoserine dehydrogenase
EGY12_RS06750	COG0527	aspartate kinase activity
EGY12_RS06755	COG0626	cystathionine gamma-synthase activity
EGY12_RS06760	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EGY12_RS06765	COG0254	rRNA binding
EGY12_RS06770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGY12_RS06775	COG1609	Transcriptional regulator
EGY12_RS06780	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EGY12_RS06785	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EGY12_RS06790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EGY12_RS06795	COG1575	Belongs to the MenA family. Type 1 subfamily
EGY12_RS06800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EGY12_RS06805	COG3074	FtsZ-dependent cytokinesis
EGY12_RS06820	COG1494	fructose-1,6-bisphosphatase
EGY12_RS06825	COG2814	Major facilitator Superfamily
EGY12_RS06840	COG3152	Membrane
EGY12_RS06850	COG0149	triose-phosphate isomerase activity
EGY12_RS06855	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EGY12_RS06860	COG0205	6-phosphofructokinase activity
EGY12_RS06865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EGY12_RS06870	COG3678	ATP-independent chaperone mediated protein folding
EGY12_RS06875	COG0745	RESPONSE REGULATOR receiver
EGY12_RS06880	COG2205	protein histidine kinase activity
EGY12_RS06885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGY12_RS06900	COG1045	serine acetyltransferase
EGY12_RS06915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EGY12_RS06920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGY12_RS06925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EGY12_RS06930	COG4942	peptidase
EGY12_RS06935	COG2861	carbohydrate metabolic process
EGY12_RS06945	COG0156	8-amino-7-oxononanoate synthase activity
EGY12_RS06950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY12_RS06955	COG0859	PFAM glycosyl transferase family 9
EGY12_RS06960	COG0859	PFAM glycosyl transferase family 9
EGY12_RS06965	COG0463	Glycosyl transferase, family 2
EGY12_RS06970	COG1442	glycosyl transferase family 8
EGY12_RS06995	COG0859	PFAM glycosyl transferase family 9
EGY12_RS07000	COG0438	transferase activity, transferring glycosyl groups
EGY12_RS07005	COG0438	transferase activity, transferring glycosyl groups
EGY12_RS07015	COG1519	Transferase
EGY12_RS07035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGY12_RS07040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EGY12_RS07045	COG2003	Belongs to the UPF0758 family
EGY12_RS07050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EGY12_RS07055	COG0756	dUTP diphosphatase activity
EGY12_RS07060	COG1309	transcriptional regulator
EGY12_RS07065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EGY12_RS07070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EGY12_RS07075	COG1561	YicC-like family, N-terminal region
EGY12_RS07085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EGY12_RS07095	COG2860	membrane
EGY12_RS07100	COG0194	GDP metabolic process
EGY12_RS07105	COG1758	RNA polymerase activity
EGY12_RS07110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGY12_RS07115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGY12_RS07120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EGY12_RS07125	COG0786	glutamate:sodium symporter activity
EGY12_RS07130	COG2233	PERMEase
EGY12_RS07135	COG2982	Protein involved in outer membrane biogenesis
EGY12_RS07140	COG0456	acetyltransferase
EGY12_RS07145	COG1490	D-aminoacyl-tRNA deacylase activity
EGY12_RS07150	COG1295	ribonuclease BN
EGY12_RS07155	COG1011	Hydrolase
EGY12_RS07160	COG1217	gtp-binding protein TYPA
EGY12_RS07165	COG0174	glutamine synthetase
EGY12_RS07170	COG3852	Histidine kinase
EGY12_RS07180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGY12_RS07190	COG3078	GTPase activator activity
EGY12_RS07200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EGY12_RS07205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGY12_RS07205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGY12_RS07210	COG0204	Acyl-transferase
EGY12_RS07215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGY12_RS07220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EGY12_RS07225	COG3084	Protein conserved in bacteria
EGY12_RS07230	COG0746	molybdenum cofactor guanylyltransferase activity
EGY12_RS07235	COG1763	Mo-molybdopterin cofactor biosynthetic process
EGY12_RS07260	COG2186	Transcriptional regulator
EGY12_RS07265	COG0477	Major facilitator Superfamily
EGY12_RS07270	COG1609	Transcriptional regulator
EGY12_RS07275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY12_RS07285	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS07290	COG1129	ABC transporter
EGY12_RS07295	COG1869	D-ribose catabolic process
EGY12_RS07300	COG3158	transport of potassium into the cell
EGY12_RS07305	COG0714	Associated with various cellular activities
EGY12_RS07310	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EGY12_RS07315	COG2502	aspartate--ammonia ligase
EGY12_RS07320	COG1522	sequence-specific DNA binding
EGY12_RS07325	COG0716	FMN binding
EGY12_RS07330	COG0445	tRNA wobble uridine modification
EGY12_RS07335	COG0357	Ribosomal RNA small subunit methyltransferase G
EGY12_RS07340	COG3312	ion transport
EGY12_RS07355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EGY12_RS07360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGY12_RS07365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EGY12_RS07370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EGY12_RS07375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EGY12_RS07380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EGY12_RS07385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EGY12_RS07395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EGY12_RS07400	COG0573	inorganic phosphate transmembrane transporter activity
EGY12_RS07405	COG0581	inorganic phosphate transmembrane transporter activity
EGY12_RS07415	COG0704	Plays a role in the regulation of phosphate uptake
EGY12_RS07420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS07425	COG0765	amino acid transport
EGY12_RS07430	COG0765	amino acid transport
EGY12_RS07435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGY12_RS07440	COG0494	nUDIX hydrolase
EGY12_RS07445	COG2252	PERMEase
EGY12_RS07455	COG0431	NADPH-dependent FMN reductase
EGY12_RS07460	COG2091	lysine biosynthetic process via aminoadipic acid
EGY12_RS07470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGY12_RS07475	COG0706	membrane insertase activity
EGY12_RS07480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGY12_RS07485	COG0594	ribonuclease P activity
EGY12_RS07500	COG0592	DNA-directed DNA polymerase activity
EGY12_RS07505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EGY12_RS07510	COG0187	DNA topoisomerase II activity
EGY12_RS07515	COG0561	phosphatase activity
EGY12_RS07520	COG2423	ornithine cyclodeaminase activity
EGY12_RS07525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGY12_RS07530	COG0823	Involved in the tonB-independent uptake of proteins
EGY12_RS07535	COG5645	(Lipo)protein
EGY12_RS07540	COG0071	Belongs to the small heat shock protein (HSP20) family
EGY12_RS07545	COG0071	Belongs to the small heat shock protein (HSP20) family
EGY12_RS07550	COG2985	domain, Protein
EGY12_RS07555	COG3977	Valine--pyruvate aminotransferase
EGY12_RS07560	COG0366	Alpha amylase catalytic
EGY12_RS07565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY12_RS07570	COG2814	Major facilitator Superfamily
EGY12_RS07575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY12_RS07585	COG1609	Transcriptional regulator
EGY12_RS07590	COG2885	chlorophyll binding
EGY12_RS07600	COG2818	Glycosylase
EGY12_RS07610	COG0752	glycyl-tRNA synthetase alpha subunit
EGY12_RS07615	COG0751	glycine-tRNA ligase activity
EGY12_RS07625	COG2213	PTS system mannitol-specific
EGY12_RS07625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY12_RS07630	COG0246	Mannitol dehydrogenase
EGY12_RS07635	COG3722	fumarate hydratase activity
EGY12_RS07645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY12_RS07660	COG2258	MOSC domain
EGY12_RS07670	COG0840	transmembrane signaling receptor activity
EGY12_RS07675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGY12_RS07680	COG0243	molybdopterin cofactor binding
EGY12_RS07680	COG3383	formate dehydrogenase (NAD+) activity
EGY12_RS07685	COG3383	formate dehydrogenase (NAD+) activity
EGY12_RS07685	COG0243	molybdopterin cofactor binding
EGY12_RS07690	COG0437	4 iron, 4 sulfur cluster binding
EGY12_RS07695	COG2864	formate dehydrogenase
EGY12_RS07700	COG3058	Necessary for formate dehydrogenase activity
EGY12_RS07710	COG0625	glutathione transferase activity
EGY12_RS07715	COG1921	L-seryl-tRNASec selenium transferase activity
EGY12_RS07720	COG3276	selenocysteine insertion sequence binding
EGY12_RS07750	COG3274	enterobacterial common antigen metabolic process
EGY12_RS07760	COG1335	isochorismatase
EGY12_RS07765	COG0402	S-adenosylhomocysteine deaminase activity
EGY12_RS07770	COG1070	Carbohydrate kinase
EGY12_RS07775	COG2115	Belongs to the xylose isomerase family
EGY12_RS07780	COG1757	Na H antiporter
EGY12_RS07790	COG1609	Transcriptional regulator
EGY12_RS07790	COG2207	Transcriptional regulator
EGY12_RS07795	COG0583	DNA-binding transcription factor activity
EGY12_RS07800	COG2807	transmembrane transport
EGY12_RS07820	COG2814	Major facilitator Superfamily
EGY12_RS07850	COG1846	Transcriptional regulator
EGY12_RS07855	COG1764	response to oxidative stress
EGY12_RS07860	COG2194	sulfuric ester hydrolase activity
EGY12_RS07865	COG2197	response regulator
EGY12_RS07875	COG2271	Major facilitator Superfamily
EGY12_RS07895	COG0747	negative chemotaxis
EGY12_RS07900	COG0601	transmembrane transport
EGY12_RS07905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY12_RS07910	COG0444	Belongs to the ABC transporter superfamily
EGY12_RS07915	COG4608	Belongs to the ABC transporter superfamily
EGY12_RS07920	COG2194	sulfuric ester hydrolase activity
EGY12_RS07945	COG1215	transferase activity, transferring glycosyl groups
EGY12_RS07950	COG1215	transferase activity, transferring glycosyl groups
EGY12_RS07955	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EGY12_RS07960	COG3118	belongs to the thioredoxin family
EGY12_RS07960	COG0457	Tetratricopeptide repeat
EGY12_RS07965	COG2199	diguanylate cyclase activity
EGY12_RS07965	COG2200	EAL domain
EGY12_RS07970	COG1301	dicarboxylic acid transport
EGY12_RS07975	COG0612	Peptidase, M16
EGY12_RS07980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY12_RS07990	COG0248	Ppx GppA phosphatase
EGY12_RS08000	COG3118	belongs to the thioredoxin family
EGY12_RS08005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EGY12_RS08010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGY12_RS08020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EGY12_RS08025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EGY12_RS08030	COG1088	dTDP-glucose 4,6-dehydratase activity
EGY12_RS08035	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EGY12_RS08040	COG0456	acetyltransferase
EGY12_RS08045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EGY12_RS08050	COG2244	polysaccharide biosynthetic process
EGY12_RS08055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGY12_RS08065	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EGY12_RS08095	COG3071	HemY protein
EGY12_RS08100	COG2959	enzyme of heme biosynthesis
EGY12_RS08110	COG0181	hydroxymethylbilane synthase activity
EGY12_RS08115	COG3072	Adenylate cyclase
EGY12_RS08120	COG1965	Belongs to the frataxin family
EGY12_RS08125	COG5567	small periplasmic lipoprotein
EGY12_RS08130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EGY12_RS08135	COG3159	Protein conserved in bacteria
EGY12_RS08145	COG1011	Hydrolase
EGY12_RS08150	COG0210	DNA helicase
EGY12_RS08170	COG2050	protein possibly involved in aromatic compounds catabolism
EGY12_RS08175	COG0514	ATP-dependent DNA helicase (RecQ)
EGY12_RS08180	COG1280	lysine exporter protein (LysE YggA)
EGY12_RS08185	COG1280	lysine exporter protein (LysE YggA)
EGY12_RS08190	COG2267	carboxylic ester hydrolase activity
EGY12_RS08195	COG0561	phosphatase activity
EGY12_RS08205	COG0584	glycerophosphoryl diester phosphodiesterase
EGY12_RS08210	COG2271	Major facilitator Superfamily
EGY12_RS08220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EGY12_RS08230	COG0247	lactate metabolic process
EGY12_RS08245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EGY12_RS08250	COG0425	Belongs to the sulfur carrier protein TusA family
EGY12_RS08270	COG3714	YhhN family
EGY12_RS08280	COG3776	membrane
EGY12_RS08285	COG0742	ribosomal rna small subunit methyltransferase
EGY12_RS08290	COG0552	protein localization to endoplasmic reticulum
EGY12_RS08290	COG0552	protein localization to endoplasmic reticulum
EGY12_RS08295	COG2884	Cell division ATP-binding protein ftsE
EGY12_RS08300	COG2177	Part of the ABC transporter FtsEX involved in
EGY12_RS08320	COG0456	acetyltransferase
EGY12_RS08330	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS08335	COG4177	L-phenylalanine transmembrane transporter activity
EGY12_RS08350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY12_RS08355	COG1653	transport
EGY12_RS08360	COG1175	transmembrane transport
EGY12_RS08370	COG3842	ATPase activity
EGY12_RS08375	COG0584	glycerophosphoryl diester phosphodiesterase
EGY12_RS08390	COG0697	spore germination
EGY12_RS08400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGY12_RS08405	COG0412	Dienelactone hydrolase
EGY12_RS08420	COG0586	Pfam SNARE associated Golgi protein
EGY12_RS08425	COG1322	Protein conserved in bacteria
EGY12_RS08430	COG2226	methyltransferase
EGY12_RS08435	COG3165	ubiquinone biosynthetic process from chorismate
EGY12_RS08440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EGY12_RS08445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGY12_RS08455	COG0805	protein transport
EGY12_RS08460	COG0084	hydrolase, TatD family'
EGY12_RS08485	COG0543	2 iron, 2 sulfur cluster binding
EGY12_RS08490	COG0183	Belongs to the thiolase family
EGY12_RS08495	COG1024	Enoyl-CoA hydratase
EGY12_RS08495	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGY12_RS08500	COG0006	proline dipeptidase activity
EGY12_RS08505	COG1739	Uncharacterized protein family UPF0029
EGY12_RS08510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EGY12_RS08540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EGY12_RS08545	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EGY12_RS08545	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EGY12_RS08550	COG1072	(Pantothenic acid kinase))
EGY12_RS08585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGY12_RS08595	COG0250	Participates in transcription elongation, termination and antitermination
EGY12_RS08610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EGY12_RS08620	COG0085	RNA polymerase activity
EGY12_RS08625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGY12_RS08640	COG3850	Histidine kinase
EGY12_RS08640	COG5002	protein histidine kinase activity
EGY12_RS08655	COG2022	thiamine diphosphate biosynthetic process
EGY12_RS08660	COG2104	thiamine diphosphate biosynthetic process
EGY12_RS08665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EGY12_RS08670	COG0352	thiamine-phosphate diphosphorylase activity
EGY12_RS08675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EGY12_RS08680	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EGY12_RS08685	COG2816	NAD+ diphosphatase activity
EGY12_RS08690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EGY12_RS08695	COG1515	deoxyribonuclease V activity
EGY12_RS08715	COG0151	Belongs to the GarS family
EGY12_RS08720	COG0138	bifunctional purine biosynthesis protein purh
EGY12_RS08750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGY12_RS08755	COG3162	membrane
EGY12_RS08760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGY12_RS08765	COG1301	dicarboxylic acid transport
EGY12_RS08770	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EGY12_RS08770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY12_RS08775	COG2226	methyltransferase
EGY12_RS08775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY12_RS08775	COG3433	isochorismatase activity
EGY12_RS08780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY12_RS08785	COG4774	siderophore transport
EGY12_RS08785	COG1629	transport
EGY12_RS08790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY12_RS08795	COG3391	amine dehydrogenase activity
EGY12_RS08800	COG4771	TonB-dependent receptor
EGY12_RS08805	COG2382	esterase
EGY12_RS08815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY12_RS08815	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EGY12_RS08830	COG1169	isochorismate synthase
EGY12_RS08835	COG1021	2,3-dihydroxybenzoate-AMP ligase
EGY12_RS08840	COG1535	isochorismatase
EGY12_RS08840	COG3433	isochorismatase activity
EGY12_RS08850	COG3647	Membrane
EGY12_RS08865	COG1309	transcriptional regulator
EGY12_RS08870	COG4232	protein-disulfide reductase activity
EGY12_RS08880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EGY12_RS08895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EGY12_RS08905	COG0840	transmembrane signaling receptor activity
EGY12_RS08915	COG1509	lysine 2,3-aminomutase activity
EGY12_RS08920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGY12_RS08925	COG5510	response to toxic substance
EGY12_RS08930	COG5510	response to toxic substance
EGY12_RS08940	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EGY12_RS08945	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EGY12_RS08950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EGY12_RS08955	COG1053	succinate dehydrogenase
EGY12_RS08960	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EGY12_RS08965	COG1511	domain protein
EGY12_RS08965	COG3264	Mechanosensitive ion channel
EGY12_RS08970	COG0688	phosphatidylethanolamine metabolic process
EGY12_RS08975	COG1162	GTPase activity
EGY12_RS08980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EGY12_RS09000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGY12_RS09005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EGY12_RS09005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EGY12_RS09010	COG0802	atpase or kinase
EGY12_RS09020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EGY12_RS09025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EGY12_RS09035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGY12_RS09040	COG0330	HflC and HflK could
EGY12_RS09045	COG0330	HflC and HflK could
EGY12_RS09050	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EGY12_RS09055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGY12_RS09060	COG1959	2 iron, 2 sulfur cluster binding
EGY12_RS09065	COG0557	exoribonuclease II activity
EGY12_RS09070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGY12_RS09075	COG1960	acyl-CoA dehydrogenase activity
EGY12_RS09080	COG3766	membrane
EGY12_RS09090	COG3650	response to hydrogen peroxide
EGY12_RS09095	COG1073	alpha beta
EGY12_RS09105	COG0360	Binds together with S18 to 16S ribosomal RNA
EGY12_RS09115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EGY12_RS09120	COG0359	binds to the 23S rRNA
EGY12_RS09130	COG3061	Opacity-associated protein A
EGY12_RS09135	COG0545	Peptidyl-prolyl cis-trans isomerase
EGY12_RS09145	COG0737	Belongs to the 5'-nucleotidase family
EGY12_RS09155	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EGY12_RS09165	COG1253	flavin adenine dinucleotide binding
EGY12_RS09170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGY12_RS09175	COG0729	surface antigen
EGY12_RS09180	COG2911	Protein conserved in bacteria
EGY12_RS09185	COG2105	PFAM AIG2 family protein
EGY12_RS09190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EGY12_RS09200	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EGY12_RS09205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGY12_RS09220	COG1438	arginine binding
EGY12_RS09225	COG0039	L-malate dehydrogenase activity
EGY12_RS09230	COG3423	Transcriptional regulator
EGY12_RS09240	COG0142	geranyltranstransferase activity
EGY12_RS09245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EGY12_RS09250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EGY12_RS09255	COG0697	spore germination
EGY12_RS09260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGY12_RS09265	COG0642	Histidine kinase
EGY12_RS09270	COG0745	RESPONSE REGULATOR receiver
EGY12_RS09275	COG2027	D-alanyl-D-alanine carboxypeptidase
EGY12_RS09285	COG1534	Rna-binding protein
EGY12_RS09290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EGY12_RS09300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EGY12_RS09305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGY12_RS09310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EGY12_RS09325	COG0779	Required for maturation of 30S ribosomal subunits
EGY12_RS09330	COG0195	Participates in both transcription termination and antitermination
EGY12_RS09335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EGY12_RS09340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EGY12_RS09345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGY12_RS09350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EGY12_RS09360	COG1185	polyribonucleotide nucleotidyltransferase activity
EGY12_RS09375	COG0513	Belongs to the DEAD box helicase family
EGY12_RS09380	COG2391	methyltransferase activity
EGY12_RS09385	COG0425	Belongs to the sulfur carrier protein TusA family
EGY12_RS09390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY12_RS09410	COG0826	peptidase U32
EGY12_RS09415	COG0826	peptidase U32
EGY12_RS09420	COG3154	lipid carrier protein
EGY12_RS09425	COG3153	acetyltransferase
EGY12_RS09430	COG2827	Endonuclease containing a URI domain
EGY12_RS09435	COG0531	amino acid
EGY12_RS09440	COG1982	Orn Lys Arg decarboxylase major
EGY12_RS09450	COG3787	Belongs to the UPF0306 family
EGY12_RS09455	COG0702	epimerase
EGY12_RS09460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EGY12_RS09470	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EGY12_RS09475	COG3454	Phosphonate metabolism
EGY12_RS09480	COG4778	phosphonate C-P lyase system protein PhnL
EGY12_RS09485	COG4107	phosphonate C-P lyase system protein PhnK
EGY12_RS09490	COG3627	carbon phosphorus lyase activity
EGY12_RS09495	COG3626	phosphonate metabolism
EGY12_RS09500	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
EGY12_RS09505	COG3624	Phosphonate C-P lyase system protein PhnG
EGY12_RS09510	COG2188	Transcriptional regulator
EGY12_RS09515	COG0701	Predicted permease
EGY12_RS09525	COG0602	queuosine metabolic process
EGY12_RS09535	COG0583	DNA-binding transcription factor activity
EGY12_RS09540	COG2249	NAD(P)H dehydrogenase (quinone) activity
EGY12_RS09545	COG0366	Alpha amylase catalytic
EGY12_RS09550	COG1263	PTS System
EGY12_RS09550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS09560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EGY12_RS09565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EGY12_RS09580	COG0540	Belongs to the ATCase OTCase family
EGY12_RS09590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGY12_RS09605	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EGY12_RS09610	COG0456	acetyltransferase
EGY12_RS09620	COG2927	DNA polymerase III (CHI subunit)
EGY12_RS09625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EGY12_RS09630	COG0795	lipopolysaccharide-transporting ATPase activity
EGY12_RS09635	COG0795	lipopolysaccharide-transporting ATPase activity
EGY12_RS09680	COG2723	6-phospho-beta-galactosidase activity
EGY12_RS09685	COG1263	PTS System
EGY12_RS09685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS09690	COG1609	Transcriptional regulator
EGY12_RS09700	COG0523	cobalamin synthesis protein
EGY12_RS09705	COG2879	small protein
EGY12_RS09710	COG1966	Carbon starvation protein
EGY12_RS09725	COG0174	glutamine synthetase
EGY12_RS09755	COG0583	DNA-binding transcription factor activity
EGY12_RS09760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EGY12_RS09775	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGY12_RS09780	COG2610	gluconate transmembrane transporter activity
EGY12_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS09800	COG2207	Transcriptional regulator
EGY12_RS09810	COG3708	Transcriptional regulator
EGY12_RS09810	COG2207	Transcriptional regulator
EGY12_RS09815	COG1376	ErfK ybiS ycfS ynhG family protein
EGY12_RS09845	COG0811	peptide transport
EGY12_RS09880	COG1454	alcohol dehydrogenase
EGY12_RS09890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY12_RS09900	COG2267	carboxylic ester hydrolase activity
EGY12_RS09930	COG1113	amino acid transport
EGY12_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS09955	COG1846	Transcriptional regulator
EGY12_RS09960	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY12_RS09970	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS09975	COG3384	dioxygenase
EGY12_RS09985	COG3971	2-oxopent-4-enoate hydratase activity
EGY12_RS10005	COG2368	4-hydroxyphenylacetate
EGY12_RS10010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGY12_RS10015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGY12_RS10020	COG2186	Transcriptional regulator
EGY12_RS10025	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS10030	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY12_RS10035	COG4948	Mandelate Racemase Muconate Lactonizing
EGY12_RS10040	COG3618	amidohydrolase
EGY12_RS10045	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS10050	COG3254	rhamnose metabolic process
EGY12_RS10055	COG0738	Major facilitator superfamily
EGY12_RS10070	COG3706	GGDEF domain
EGY12_RS10100	COG0667	Aldo Keto reductase
EGY12_RS10105	COG2813	Specifically methylates the guanine in position
EGY12_RS10110	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
EGY12_RS10120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EGY12_RS10125	COG2823	Periplasmic or secreted lipoprotein
EGY12_RS10130	COG5487	UPF0391 membrane protein
EGY12_RS10135	COG3237	CsbD-like
EGY12_RS10140	COG4667	esterase of the alpha-beta hydrolase superfamily
EGY12_RS10145	COG0084	hydrolase, TatD family'
EGY12_RS10150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EGY12_RS10155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EGY12_RS10165	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EGY12_RS10170	COG0813	purine-nucleoside phosphorylase activity
EGY12_RS10175	COG3726	membrane protein affecting hemolysin expression
EGY12_RS10180	COG0560	Phosphoserine phosphatase
EGY12_RS10200	COG0604	alcohol dehydrogenase
EGY12_RS10210	COG0488	(ABC) transporter
EGY12_RS10215	COG2885	chlorophyll binding
EGY12_RS10220	COG2199	diguanylate cyclase activity
EGY12_RS10230	COG0741	lytic transglycosylase activity
EGY12_RS10235	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EGY12_RS10240	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EGY12_RS10245	COG0406	alpha-ribazole phosphatase activity
EGY12_RS10250	COG3708	Transcriptional regulator
EGY12_RS10250	COG2207	Transcriptional regulator
EGY12_RS10255	COG3045	CreA protein
EGY12_RS10260	COG0745	RESPONSE REGULATOR receiver
EGY12_RS10290	COG3022	response to hydroperoxide
EGY12_RS10295	COG1115	amino acid carrier protein
EGY12_RS10300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EGY12_RS10305	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGY12_RS10315	COG1584	GPR1 FUN34 yaaH family protein
EGY12_RS10320	COG0443	Heat shock 70 kDa protein
EGY12_RS10325	COG0484	heat shock protein binding
EGY12_RS10330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EGY12_RS10335	COG0583	DNA-binding transcription factor activity
EGY12_RS10340	COG0268	Binds directly to 16S ribosomal RNA
EGY12_RS10350	COG0196	riboflavin kinase activity
EGY12_RS10360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGY12_RS10365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EGY12_RS10370	COG1047	Peptidyl-prolyl cis-trans
EGY12_RS10375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EGY12_RS10380	COG0583	DNA-binding transcription factor activity
EGY12_RS10400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGY12_RS10405	COG0505	Belongs to the CarA family
EGY12_RS10430	COG2966	Psort location CytoplasmicMembrane, score
EGY12_RS10440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EGY12_RS10450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGY12_RS10455	COG2967	ApaG domain
EGY12_RS10460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGY12_RS10465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EGY12_RS10475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EGY12_RS10485	COG0564	pseudouridine synthase activity
EGY12_RS10490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGY12_RS10495	COG0417	DNA replication proofreading
EGY12_RS10500	COG0586	Pfam SNARE associated Golgi protein
EGY12_RS10505	COG0440	acetolactate synthase activity
EGY12_RS10510	COG0028	Belongs to the TPP enzyme family
EGY12_RS10525	COG1178	ABC-type Fe3 transport system permease component
EGY12_RS10530	COG4143	(ABC) transporter
EGY12_RS10545	COG2814	Major facilitator Superfamily
EGY12_RS10550	COG0471	metal ion transport
EGY12_RS10555	COG0066	3-isopropylmalate dehydratase activity
EGY12_RS10560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGY12_RS10565	COG0473	3-isopropylmalate dehydrogenase activity
EGY12_RS10570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY12_RS10580	COG0583	DNA-binding transcription factor activity
EGY12_RS10585	COG1022	Amp-dependent synthetase and ligase
EGY12_RS10590	COG0028	Belongs to the TPP enzyme family
EGY12_RS10610	COG2001	Belongs to the MraZ family
EGY12_RS10615	COG0275	rRNA processing
EGY12_RS10620	COG3116	cell division
EGY12_RS10625	COG0768	penicillin binding
EGY12_RS10630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGY12_RS10635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EGY12_RS10640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGY12_RS10650	COG0772	Belongs to the SEDS family
EGY12_RS10655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGY12_RS10660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGY12_RS10670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EGY12_RS10675	COG0849	cell division
EGY12_RS10680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EGY12_RS10700	COG0653	protein targeting
EGY12_RS10705	COG0494	nUDIX hydrolase
EGY12_RS10710	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EGY12_RS10715	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EGY12_RS10725	COG0516	GMP reductase activity
EGY12_RS10730	COG1459	type II secretion system
EGY12_RS10735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGY12_RS10740	COG4969	Belongs to the N-Me-Phe pilin family
EGY12_RS10750	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGY12_RS10755	COG3725	Membrane protein required for beta-lactamase induction
EGY12_RS10760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EGY12_RS10770	COG0316	Belongs to the HesB IscA family
EGY12_RS10780	COG2860	membrane
EGY12_RS10790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGY12_RS10795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EGY12_RS10800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGY12_RS10810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGY12_RS10815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGY12_RS10820	COG3956	TIGRFAM MazG family protein
EGY12_RS10825	COG0504	CTP synthase activity
EGY12_RS10855	COG2986	histidine ammonia-lyase
EGY12_RS10860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EGY12_RS10865	COG2271	Major facilitator Superfamily
EGY12_RS10870	COG0602	queuosine metabolic process
EGY12_RS10875	COG0720	synthase
EGY12_RS10880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGY12_RS10885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGY12_RS10890	COG0175	sulfate reduction
EGY12_RS10895	COG2234	aminopeptidase activity
EGY12_RS10900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGY12_RS10900	COG1648	precorrin-2 dehydrogenase activity
EGY12_RS10905	COG0175	sulfate reduction
EGY12_RS10910	COG2895	sulfate adenylyltransferase (ATP) activity
EGY12_RS10930	COG0765	amino acid transport
EGY12_RS10940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EGY12_RS10945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EGY12_RS10950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EGY12_RS10955	COG0585	pseudouridine synthase activity
EGY12_RS10960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EGY12_RS10965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EGY12_RS10970	COG1388	LysM domain
EGY12_RS10970	COG4942	peptidase
EGY12_RS10975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGY12_RS10980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EGY12_RS10990	COG0667	Aldo Keto reductase
EGY12_RS11005	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGY12_RS11010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGY12_RS11015	COG2723	6-phospho-beta-galactosidase activity
EGY12_RS11020	COG1917	Cupin 2, conserved barrel domain protein
EGY12_RS11020	COG2169	Transcriptional regulator
EGY12_RS11045	COG2137	regulation of response to DNA damage stimulus
EGY12_RS11050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGY12_RS11055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EGY12_RS11080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGY12_RS11085	COG1238	metal cluster binding
EGY12_RS11090	COG2918	glutathione biosynthetic process
EGY12_RS11100	COG4536	flavin adenine dinucleotide binding
EGY12_RS11105	COG4137	Cytochrome C assembly protein
EGY12_RS11110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGY12_RS11120	COG0228	four-way junction DNA binding
EGY12_RS11125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EGY12_RS11155	COG3137	Salt-induced outer membrane protein
EGY12_RS11160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGY12_RS11165	COG0287	Prephenate dehydrogenase
EGY12_RS11165	COG1605	Chorismate mutase
EGY12_RS11170	COG0077	Prephenate dehydratase
EGY12_RS11170	COG1605	Chorismate mutase
EGY12_RS11180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EGY12_RS11185	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY12_RS11195	COG0564	pseudouridine synthase activity
EGY12_RS11205	COG0542	response to heat
EGY12_RS11235	COG0656	L-ascorbic acid biosynthetic process
EGY12_RS11240	COG0583	DNA-binding transcription factor activity
EGY12_RS11250	COG1388	LysM domain
EGY12_RS11250	COG0741	lytic transglycosylase activity
EGY12_RS11255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGY12_RS11260	COG2226	methyltransferase
EGY12_RS11265	COG0328	RNA-DNA hybrid ribonuclease activity
EGY12_RS11270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGY12_RS11295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EGY12_RS11300	COG1280	lysine exporter protein (LysE YggA)
EGY12_RS11310	COG0436	Aminotransferase
EGY12_RS11315	COG0235	Class ii aldolase
EGY12_RS11320	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EGY12_RS11325	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EGY12_RS11330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EGY12_RS11335	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EGY12_RS11340	COG0831	urea catabolic process
EGY12_RS11345	COG0832	Belongs to the urease beta subunit family
EGY12_RS11350	COG0804	urea catabolic process
EGY12_RS11355	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EGY12_RS11360	COG0830	nickel cation binding
EGY12_RS11365	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EGY12_RS11370	COG0829	nickel cation binding
EGY12_RS11375	COG4413	Urea transporter
EGY12_RS11380	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EGY12_RS11390	COG1960	acyl-CoA dehydrogenase activity
EGY12_RS11395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EGY12_RS11400	COG0121	glutamine amidotransferase
EGY12_RS11405	COG3034	peptidoglycan biosynthetic process
EGY12_RS11410	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGY12_RS11415	COG1805	sodium ion transport
EGY12_RS11420	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGY12_RS11425	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGY12_RS11430	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGY12_RS11435	COG2871	sodium ion transport
EGY12_RS11440	COG1477	protein flavinylation
EGY12_RS11445	COG2991	Protein conserved in bacteria
EGY12_RS11450	COG0584	glycerophosphoryl diester phosphodiesterase
EGY12_RS11455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGY12_RS11460	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGY12_RS11465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EGY12_RS11470	COG1073	alpha beta
EGY12_RS11520	COG0582	viral genome integration into host DNA
EGY12_RS11595	COG2314	TM2 domain
EGY12_RS11625	COG3038	cytochrome b561
EGY12_RS11630	COG0747	negative chemotaxis
EGY12_RS11635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGY12_RS11640	COG1733	regulation of RNA biosynthetic process
EGY12_RS11645	COG2249	NAD(P)H dehydrogenase (quinone) activity
EGY12_RS11660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGY12_RS11670	COG2207	Transcriptional regulator
EGY12_RS11675	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS11700	COG3961	Belongs to the TPP enzyme family
EGY12_RS11735	COG1349	DNA-binding transcription factor activity
EGY12_RS11740	COG0346	lactoylglutathione lyase activity
EGY12_RS11755	COG1335	isochorismatase
EGY12_RS11765	COG3011	Protein conserved in bacteria
EGY12_RS11775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY12_RS11780	COG3416	Protein conserved in bacteria
EGY12_RS11790	COG2226	methyltransferase
EGY12_RS11840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EGY12_RS11875	COG4126	flavin adenine dinucleotide binding
EGY12_RS11880	COG3123	guanosine phosphorylase activity
EGY12_RS11885	COG2974	May be involved in recombination
EGY12_RS11890	COG1940	carbohydrate kinase activity
EGY12_RS11900	COG0419	ATPase involved in DNA repair
EGY12_RS11905	COG0420	3'-5' exonuclease activity
EGY12_RS11910	COG0745	RESPONSE REGULATOR receiver
EGY12_RS11915	COG5002	protein histidine kinase activity
EGY12_RS11935	COG3093	addiction module antidote protein HigA
EGY12_RS11950	COG0668	transmembrane transport
EGY12_RS11955	COG0366	Alpha amylase catalytic
EGY12_RS11965	COG0450	alkyl hydroperoxide reductase
EGY12_RS11970	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EGY12_RS11975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EGY12_RS11980	COG0343	queuine tRNA-ribosyltransferase activity
EGY12_RS11985	COG1862	Preprotein translocase
EGY12_RS11995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGY12_RS12000	COG4238	major outer membrane lipoprotein
EGY12_RS12005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGY12_RS12010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGY12_RS12010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGY12_RS12015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EGY12_RS12020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGY12_RS12025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EGY12_RS12030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EGY12_RS12035	COG0667	Aldo Keto reductase
EGY12_RS12040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EGY12_RS12045	COG0142	geranyltranstransferase activity
EGY12_RS12050	COG1722	exodeoxyribonuclease VII activity
EGY12_RS12055	COG0301	tRNA thio-modification
EGY12_RS12055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGY12_RS12060	COG0693	protein deglycase activity
EGY12_RS12065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EGY12_RS12070	COG1666	GTP binding
EGY12_RS12075	COG2814	Major facilitator Superfamily
EGY12_RS12080	COG0109	protoheme IX farnesyltransferase activity
EGY12_RS12085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EGY12_RS12090	COG1845	cytochrome c oxidase, subunit III
EGY12_RS12095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EGY12_RS12100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EGY12_RS12105	COG2223	nitrite transmembrane transporter activity
EGY12_RS12110	COG3056	Lipoprotein
EGY12_RS12115	COG0271	Belongs to the BolA IbaG family
EGY12_RS12120	COG0544	peptidyl-prolyl cis-trans isomerase activity
EGY12_RS12130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EGY12_RS12135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EGY12_RS12145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY12_RS12150	COG1555	photosystem II stabilization
EGY12_RS12155	COG0824	Thioesterase
EGY12_RS12160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EGY12_RS12165	COG4533	DNA binding
EGY12_RS12170	COG0561	phosphatase activity
EGY12_RS12180	COG1522	sequence-specific DNA binding
EGY12_RS12185	COG1132	(ABC) transporter
EGY12_RS12190	COG1132	(ABC) transporter
EGY12_RS12195	COG0347	Belongs to the P(II) protein family
EGY12_RS12200	COG0004	ammonium transporteR
EGY12_RS12205	COG1946	Acyl-CoA thioesterase
EGY12_RS12210	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EGY12_RS12215	COG3695	enzyme binding
EGY12_RS12240	COG1121	(ABC) transporter
EGY12_RS12245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGY12_RS12250	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGY12_RS12255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGY12_RS12260	COG0254	rRNA binding
EGY12_RS12265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY12_RS12270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY12_RS12275	COG1309	transcriptional regulator
EGY12_RS12280	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EGY12_RS12285	COG3264	Mechanosensitive ion channel
EGY12_RS12285	COG1196	nuclear chromosome segregation
EGY12_RS12300	COG2832	Protein of unknown function (DUF454)
EGY12_RS12305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGY12_RS12310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EGY12_RS12320	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EGY12_RS12325	COG0326	Molecular chaperone. Has ATPase activity
EGY12_RS12330	COG0563	adenylate kinase activity
EGY12_RS12335	COG3835	regulator
EGY12_RS12340	COG2610	gluconate transmembrane transporter activity
EGY12_RS12345	COG1929	Belongs to the glycerate kinase type-1 family
EGY12_RS12360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGY12_RS12365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY12_RS12370	COG4651	solute:proton antiporter activity
EGY12_RS12370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EGY12_RS12375	COG2223	nitrite transmembrane transporter activity
EGY12_RS12380	COG0737	Belongs to the 5'-nucleotidase family
EGY12_RS12385	COG2027	D-alanyl-D-alanine carboxypeptidase
EGY12_RS12390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGY12_RS12395	COG3735	TraB family
EGY12_RS12400	COG2217	Heavy metal translocating P-type atpase
EGY12_RS12410	COG2207	Transcriptional regulator
EGY12_RS12415	COG0789	Transcriptional regulator
EGY12_RS12420	COG1585	Membrane protein implicated in regulation of membrane protease activity
EGY12_RS12425	COG0330	HflC and HflK could
EGY12_RS12430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGY12_RS12435	COG3118	belongs to the thioredoxin family
EGY12_RS12440	COG0300	oxidoreductase activity
EGY12_RS12445	COG2755	lipolytic protein G-D-S-L family
EGY12_RS12450	COG4181	ATPase activity
EGY12_RS12455	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EGY12_RS12460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EGY12_RS12465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EGY12_RS12470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY12_RS12475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EGY12_RS12480	COG0215	cysteine-tRNA ligase activity
EGY12_RS12485	COG2501	S4 domain
EGY12_RS12490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGY12_RS12525	COG2199	diguanylate cyclase activity
EGY12_RS12530	COG1278	Cold shock
EGY12_RS12540	COG1126	abc transporter atp-binding protein
EGY12_RS12545	COG0765	amino acid transport
EGY12_RS12555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS12560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY12_RS12565	COG1473	amidohydrolase
EGY12_RS12575	COG2814	Major facilitator Superfamily
EGY12_RS12585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EGY12_RS12595	COG3706	GGDEF domain
EGY12_RS12605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGY12_RS12610	COG0321	lipoyl(octanoyl) transferase activity
EGY12_RS12620	COG1686	Belongs to the peptidase S11 family
EGY12_RS12625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EGY12_RS12630	COG0772	Belongs to the SEDS family
EGY12_RS12635	COG0768	penicillin binding
EGY12_RS12640	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EGY12_RS12645	COG0799	negative regulation of ribosome biogenesis
EGY12_RS12650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EGY12_RS12655	COG1466	dna polymerase III delta subunit
EGY12_RS12660	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EGY12_RS12665	COG0495	leucyl-tRNA aminoacylation
EGY12_RS12670	COG2888	peptidyl-tyrosine sulfation
EGY12_RS12680	COG1957	nucleoside hydrolase
EGY12_RS12685	COG1126	abc transporter atp-binding protein
EGY12_RS12690	COG0765	amino acid transport
EGY12_RS12695	COG0765	amino acid transport
EGY12_RS12705	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EGY12_RS12710	COG4535	Mg2 and Co2 transporter CorC
EGY12_RS12715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EGY12_RS12720	COG1702	phosphate starvation-inducible protein PhoH
EGY12_RS12730	COG2824	Alkylphosphonate utilization operon protein PhnA
EGY12_RS12735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGY12_RS12740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY12_RS12775	COG0367	asparagine synthase
EGY12_RS12780	COG3469	chitinase activity
EGY12_RS12785	COG0647	UMP catabolic process
EGY12_RS12790	COG1940	carbohydrate kinase activity
EGY12_RS12790	COG1846	Transcriptional regulator
EGY12_RS12795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EGY12_RS12800	COG0363	glucosamine-6-phosphate deaminase activity
EGY12_RS12805	COG2190	(PTS) system
EGY12_RS12805	COG1263	PTS System
EGY12_RS12805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS12810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGY12_RS12830	COG0735	belongs to the Fur family
EGY12_RS12845	COG0596	Alpha beta hydrolase
EGY12_RS12850	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EGY12_RS12855	COG0033	Phosphoglucomutase
EGY12_RS12860	COG1695	Transcriptional regulator
EGY12_RS12870	COG0745	RESPONSE REGULATOR receiver
EGY12_RS12875	COG2205	protein histidine kinase activity
EGY12_RS12880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EGY12_RS12885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EGY12_RS12890	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EGY12_RS12905	COG3272	Protein of unknown function (DUF1722)
EGY12_RS12915	COG5212	phosphodiesterase
EGY12_RS12920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EGY12_RS12925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EGY12_RS12930	COG1984	allophanate hydrolase subunit 2
EGY12_RS12935	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EGY12_RS12970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EGY12_RS12975	COG1053	succinate dehydrogenase
EGY12_RS12980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EGY12_RS12985	COG0567	Dehydrogenase, E1 component
EGY12_RS12990	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGY12_RS12995	COG0045	succinate-CoA ligase (ADP-forming) activity
EGY12_RS13000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGY12_RS13005	COG0737	Belongs to the 5'-nucleotidase family
EGY12_RS13010	COG1271	oxidase subunit
EGY12_RS13015	COG1294	oxidase, subunit
EGY12_RS13020	COG4890	Cyd operon protein YbgT
EGY12_RS13025	COG3790	cyd operon protein YbgE
EGY12_RS13030	COG0824	Thioesterase
EGY12_RS13035	COG0811	peptide transport
EGY12_RS13040	COG0848	biopolymer transport protein
EGY12_RS13045	COG3064	Membrane
EGY12_RS13050	COG0823	Involved in the tonB-independent uptake of proteins
EGY12_RS13055	COG2885	chlorophyll binding
EGY12_RS13060	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EGY12_RS13100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EGY12_RS13110	COG1230	cation diffusion facilitator family transporter
EGY12_RS13115	COG2205	protein histidine kinase activity
EGY12_RS13115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS13120	COG2197	response regulator
EGY12_RS13125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGY12_RS13140	COG0588	phosphoglycerate mutase activity
EGY12_RS13150	COG2017	converts alpha-aldose to the beta-anomer
EGY12_RS13155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EGY12_RS13160	COG1085	galactose-1-phosphate uridylyltransferase
EGY12_RS13175	COG1119	ATPase activity
EGY12_RS13180	COG2005	Transcriptional regulator
EGY12_RS13180	COG3585	molybdate ion transport
EGY12_RS13185	COG4774	siderophore transport
EGY12_RS13195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EGY12_RS13200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY12_RS13205	COG1120	ATPase activity
EGY12_RS13215	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGY12_RS13220	COG4149	molybdate abc transporter
EGY12_RS13230	COG0561	phosphatase activity
EGY12_RS13235	COG2706	6-phosphogluconolactonase activity
EGY12_RS13240	COG1881	PFAM PEBP family protein
EGY12_RS13285	COG0556	nucleotide-excision repair
EGY12_RS13290	COG4628	conserved protein (DUF2132)
EGY12_RS13295	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EGY12_RS13300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EGY12_RS13305	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGY12_RS13310	COG0315	cyclic pyranopterin monophosphate synthase activity
EGY12_RS13315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EGY12_RS13320	COG0314	molybdopterin synthase activity
EGY12_RS13325	COG0670	Belongs to the BI1 family
EGY12_RS13330	COG0842	Transport permease protein
EGY12_RS13335	COG0842	Transport permease protein
EGY12_RS13340	COG1131	(ABC) transporter
EGY12_RS13345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY12_RS13350	COG1309	transcriptional regulator
EGY12_RS13355	COG0513	Belongs to the DEAD box helicase family
EGY12_RS13360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY12_RS13365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGY12_RS13375	COG3842	ATPase activity
EGY12_RS13385	COG1840	ABC-type Fe3 transport system, periplasmic component
EGY12_RS13390	COG2271	Major facilitator Superfamily
EGY12_RS13410	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS13415	COG0583	DNA-binding transcription factor activity
EGY12_RS13435	COG0583	DNA-binding transcription factor activity
EGY12_RS13445	COG0586	Pfam SNARE associated Golgi protein
EGY12_RS13455	COG4977	sequence-specific DNA binding
EGY12_RS13460	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EGY12_RS13465	COG1686	Belongs to the peptidase S11 family
EGY12_RS13495	COG2354	Protein conserved in bacteria
EGY12_RS13515	COG1464	Belongs to the NlpA lipoprotein family
EGY12_RS13525	COG0456	acetyltransferase
EGY12_RS13530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EGY12_RS13545	COG0277	FAD linked oxidase domain protein
EGY12_RS13560	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGY12_RS13570	COG0436	Aminotransferase
EGY12_RS13580	COG1472	Belongs to the glycosyl hydrolase 3 family
EGY12_RS13605	COG2134	cdp-diacylglycerol pyrophosphatase
EGY12_RS13615	COG1192	Involved in chromosome partitioning
EGY12_RS13630	COG0583	DNA-binding transcription factor activity
EGY12_RS13645	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EGY12_RS13650	COG0697	spore germination
EGY12_RS13690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EGY12_RS13705	COG1309	transcriptional regulator
EGY12_RS13710	COG1464	Belongs to the NlpA lipoprotein family
EGY12_RS13715	COG2011	ABC-type metal ion transport system permease component
EGY12_RS13720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGY12_RS13725	COG0519	Catalyzes the synthesis of GMP from XMP
EGY12_RS13740	COG1335	isochorismatase
EGY12_RS13745	COG2084	Dehydrogenase
EGY12_RS13760	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EGY12_RS13775	COG4807	Protein conserved in bacteria
EGY12_RS13790	COG1802	Transcriptional regulator
EGY12_RS13810	COG0411	ABC transporter
EGY12_RS13845	COG0583	DNA-binding transcription factor activity
EGY12_RS13850	COG2897	thiosulfate sulfurtransferase activity
EGY12_RS13855	COG0494	nUDIX hydrolase
EGY12_RS13860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY12_RS13870	COG0625	glutathione transferase activity
EGY12_RS13880	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EGY12_RS13890	COG1335	isochorismatase
EGY12_RS13895	COG0583	DNA-binding transcription factor activity
EGY12_RS13910	COG1732	Glycine betaine
EGY12_RS13915	COG1174	glycine betaine transport
EGY12_RS13920	COG1125	glycine betaine transport
EGY12_RS13925	COG1174	glycine betaine transport
EGY12_RS13945	COG0697	spore germination
EGY12_RS13975	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EGY12_RS13990	COG0625	glutathione transferase activity
EGY12_RS13995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGY12_RS14000	COG1942	4-Oxalocrotonate Tautomerase
EGY12_RS14010	COG1522	sequence-specific DNA binding
EGY12_RS14035	COG2079	MmgE PrpD family protein
EGY12_RS14040	COG1280	lysine exporter protein (LysE YggA)
EGY12_RS14050	COG0477	Major facilitator Superfamily
EGY12_RS14060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGY12_RS14085	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EGY12_RS14095	COG1309	transcriptional regulator
EGY12_RS14100	COG1214	PFAM Peptidase M22, glycoprotease
EGY12_RS14100	COG0456	acetyltransferase
EGY12_RS14110	COG0668	transmembrane transport
EGY12_RS14115	COG1126	abc transporter atp-binding protein
EGY12_RS14120	COG0765	amino acid transport
EGY12_RS14125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS14130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EGY12_RS14145	COG2731	YhcH YjgK YiaL family protein
EGY12_RS14155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EGY12_RS14160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY12_RS14175	COG2610	gluconate transmembrane transporter activity
EGY12_RS14180	COG3622	Belongs to the hyi family
EGY12_RS14185	COG0235	Class ii aldolase
EGY12_RS14190	COG3395	kinase activity
EGY12_RS14195	COG2084	Dehydrogenase
EGY12_RS14200	COG1349	DNA-binding transcription factor activity
EGY12_RS14210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EGY12_RS14215	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
EGY12_RS14255	COG3188	usher protein
EGY12_RS14270	COG5002	protein histidine kinase activity
EGY12_RS14275	COG0745	RESPONSE REGULATOR receiver
EGY12_RS14280	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
EGY12_RS14285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EGY12_RS14300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGY12_RS14310	COG1309	transcriptional regulator
EGY12_RS14315	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS14320	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EGY12_RS14325	COG0069	glutamate synthase activity
EGY12_RS14335	COG2200	EAL domain
EGY12_RS14345	COG3121	Chaperone
EGY12_RS14350	COG3188	usher protein
EGY12_RS14360	COG2207	Transcriptional regulator
EGY12_RS14360	COG3708	Transcriptional regulator
EGY12_RS14365	COG0579	oxidoreductase
EGY12_RS14375	COG0625	glutathione transferase activity
EGY12_RS14380	COG0640	Transcriptional regulator
EGY12_RS14400	COG3811	Belongs to the UPF0386 family
EGY12_RS14405	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EGY12_RS14415	COG0583	DNA-binding transcription factor activity
EGY12_RS14430	COG1942	4-Oxalocrotonate Tautomerase
EGY12_RS14440	COG0488	(ABC) transporter
EGY12_RS14445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EGY12_RS14450	COG0303	'Molybdopterin
EGY12_RS14465	COG4172	Belongs to the ABC transporter superfamily
EGY12_RS14470	COG0747	negative chemotaxis
EGY12_RS14475	COG0601	transmembrane transport
EGY12_RS14480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY12_RS14495	COG0583	DNA-binding transcription factor activity
EGY12_RS14500	COG0477	Major facilitator Superfamily
EGY12_RS14505	COG0302	gtp cyclohydrolase
EGY12_RS14510	COG2311	Membrane
EGY12_RS14515	COG1609	Transcriptional regulator
EGY12_RS14535	COG2949	membrane
EGY12_RS14540	COG1215	transferase activity, transferring glycosyl groups
EGY12_RS14545	COG2244	polysaccharide biosynthetic process
EGY12_RS14550	COG0281	malic enzyme
EGY12_RS14555	COG0295	cytidine deaminase activity
EGY12_RS14560	COG1346	cytolysis
EGY12_RS14565	COG1380	Effector of murein hydrolase LrgA
EGY12_RS14570	COG2814	Major facilitator Superfamily
EGY12_RS14580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY12_RS14580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY12_RS14585	COG0489	protein tyrosine kinase activity
EGY12_RS14595	COG0572	uridine kinase
EGY12_RS14600	COG0717	Belongs to the dCTP deaminase family
EGY12_RS14605	COG2982	Protein involved in outer membrane biogenesis
EGY12_RS14610	COG3069	C4-dicarboxylate transmembrane transporter activity
EGY12_RS14615	COG1253	flavin adenine dinucleotide binding
EGY12_RS14620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGY12_RS14625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGY12_RS14670	COG0438	transferase activity, transferring glycosyl groups
EGY12_RS14710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGY12_RS14725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGY12_RS14740	COG1442	glycosyl transferase family 8
EGY12_RS14765	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EGY12_RS14785	COG0140	phosphoribosyl-ATP diphosphatase activity
EGY12_RS14785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EGY12_RS14790	COG0107	imidazoleglycerol-phosphate synthase activity
EGY12_RS14795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EGY12_RS14810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGY12_RS14815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EGY12_RS14820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EGY12_RS14830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY12_RS14835	COG0583	DNA-binding transcription factor activity
EGY12_RS14840	COG2814	Major facilitator Superfamily
EGY12_RS14860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY12_RS14860	COG3153	acetyltransferase
EGY12_RS14865	COG0598	Magnesium transport protein CorA
EGY12_RS14875	COG2133	pyrroloquinoline quinone binding
EGY12_RS14880	COG0625	glutathione transferase activity
EGY12_RS14900	COG0626	cystathionine gamma-synthase activity
EGY12_RS14910	COG1686	Belongs to the peptidase S11 family
EGY12_RS14935	COG3539	Fimbrial protein
EGY12_RS14940	COG3188	usher protein
EGY12_RS14945	COG3121	Chaperone
EGY12_RS14965	COG0545	Peptidyl-prolyl cis-trans isomerase
EGY12_RS14970	COG2197	response regulator
EGY12_RS14975	COG1760	l-serine dehydratase
EGY12_RS14980	COG0814	amino acid
EGY12_RS14985	COG1349	DNA-binding transcription factor activity
EGY12_RS14990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EGY12_RS15000	COG0671	phosphoesterase, PA-phosphatase related
EGY12_RS15015	COG4574	serine-type endopeptidase inhibitor activity
EGY12_RS15030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EGY12_RS15070	COG2207	Transcriptional regulator
EGY12_RS15080	COG4695	Portal protein
EGY12_RS15095	COG2985	domain, Protein
EGY12_RS15095	COG0569	domain protein
EGY12_RS15115	COG0189	ligase activity
EGY12_RS15125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EGY12_RS15130	COG3842	ATPase activity
EGY12_RS15135	COG1176	ABC-type spermidine putrescine transport system, permease component I
EGY12_RS15140	COG1177	transmembrane transport
EGY12_RS15150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGY12_RS15155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS15160	COG4160	amino acid transport
EGY12_RS15165	COG4215	(ABC) transporter
EGY12_RS15170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS15175	COG1126	abc transporter atp-binding protein
EGY12_RS15185	COG0393	Putative heavy-metal-binding
EGY12_RS15190	COG3064	Membrane
EGY12_RS15195	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGY12_RS15200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY12_RS15205	COG0702	epimerase
EGY12_RS15215	COG1737	Transcriptional regulator
EGY12_RS15220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS15220	COG1263	PTS System
EGY12_RS15220	COG2190	(PTS) system
EGY12_RS15225	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EGY12_RS15230	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EGY12_RS15235	COG0028	Belongs to the TPP enzyme family
EGY12_RS15240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY12_RS15245	COG1151	hydroxylamine reductase activity
EGY12_RS15250	COG2431	L-lysine efflux transmembrane transporter activity
EGY12_RS15255	COG3593	DNA synthesis involved in DNA repair
EGY12_RS15260	COG2990	Protein conserved in bacteria
EGY12_RS15265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY12_RS15275	COG1278	Cold shock
EGY12_RS15280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EGY12_RS15285	COG0542	response to heat
EGY12_RS15290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EGY12_RS15295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EGY12_RS15300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EGY12_RS15310	COG0492	ferredoxin-NADP+ reductase activity
EGY12_RS15325	COG3107	peptidoglycan biosynthetic process
EGY12_RS15325	COG1674	ftsk spoiiie
EGY12_RS15330	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EGY12_RS15335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EGY12_RS15340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGY12_RS15350	COG2814	Major facilitator Superfamily
EGY12_RS15355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EGY12_RS15360	COG1882	Formate acetyltransferase
EGY12_RS15365	COG2116	formate transmembrane transporter activity
EGY12_RS15370	COG1944	ATP diphosphatase activity
EGY12_RS15375	COG0252	asparaginase activity
EGY12_RS15380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EGY12_RS15385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EGY12_RS15390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EGY12_RS15395	COG0539	negative regulation of cytoplasmic translation
EGY12_RS15405	COG2333	competence protein COMEC
EGY12_RS15405	COG0658	competence protein
EGY12_RS15410	COG1132	(ABC) transporter
EGY12_RS15415	COG1663	tetraacyldisaccharide 4'-kinase activity
EGY12_RS15420	COG5383	Protein conserved in bacteria
EGY12_RS15430	COG1278	Cold shock
EGY12_RS15435	COG3214	Protein conserved in bacteria
EGY12_RS15440	COG2835	tetraacyldisaccharide 4'-kinase activity
EGY12_RS15445	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EGY12_RS15450	COG3173	Aminoglycoside phosphotransferase
EGY12_RS15455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EGY12_RS15460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EGY12_RS15465	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EGY12_RS15475	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EGY12_RS15480	COG2989	Protein conserved in bacteria
EGY12_RS15485	COG3108	Peptidase M15
EGY12_RS15490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGY12_RS15500	COG1448	Aminotransferase
EGY12_RS15510	COG0017	Asparaginyl-tRNA synthetase
EGY12_RS15515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EGY12_RS15520	COG3706	GGDEF domain
EGY12_RS15525	COG0308	aminopeptidase N
EGY12_RS15535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY12_RS15540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY12_RS15545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGY12_RS15550	COG0431	NADPH-dependent FMN reductase
EGY12_RS15555	COG0167	dihydroorotate dehydrogenase activity
EGY12_RS15565	COG0633	Ferredoxin
EGY12_RS15565	COG3217	Mosc domain protein beta barrel domain protein
EGY12_RS15570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EGY12_RS15570	COG0116	Belongs to the methyltransferase superfamily
EGY12_RS15575	COG0488	(ABC) transporter
EGY12_RS15580	COG2995	paraquat-inducible protein a
EGY12_RS15585	COG3008	intermembrane lipid transfer
EGY12_RS15585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGY12_RS15590	COG3009	Protein conserved in bacteria
EGY12_RS15595	COG3130	regulation of translation
EGY12_RS15600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGY12_RS15610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGY12_RS15615	COG1067	ATP-dependent peptidase activity
EGY12_RS15635	COG3070	regulator of competence-specific genes
EGY12_RS15640	COG1289	transmembrane transporter activity
EGY12_RS15645	COG3304	Inner membrane component domain
EGY12_RS15650	COG0210	DNA helicase
EGY12_RS15655	COG1803	Methylglyoxal synthase
EGY12_RS15665	COG1832	CoA-binding protein
EGY12_RS15670	COG3785	DNA binding
EGY12_RS15675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EGY12_RS15680	COG1254	Belongs to the acylphosphatase family
EGY12_RS15685	COG2920	part of a sulfur-relay system
EGY12_RS15690	COG0670	Belongs to the BI1 family
EGY12_RS15715	COG2197	response regulator
EGY12_RS15725	COG3121	Chaperone
EGY12_RS15730	COG3188	usher protein
EGY12_RS15740	COG0789	Transcriptional regulator
EGY12_RS15745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY12_RS15750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY12_RS15765	COG0655	NAD(P)H dehydrogenase (quinone) activity
EGY12_RS15785	COG1113	amino acid transport
EGY12_RS15795	COG0586	Pfam SNARE associated Golgi protein
EGY12_RS15800	COG2271	Major facilitator Superfamily
EGY12_RS15820	COG2814	Major facilitator Superfamily
EGY12_RS15825	COG2197	response regulator
EGY12_RS15830	COG0589	response to stress
EGY12_RS15845	COG0531	amino acid
EGY12_RS15850	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS15855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY12_RS15900	COG3136	membrane protein required for alginate biosynthesis
EGY12_RS15910	COG2197	response regulator
EGY12_RS15915	COG0322	excinuclease ABC activity
EGY12_RS15950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EGY12_RS15985	COG0322	excinuclease ABC activity
EGY12_RS16020	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EGY12_RS16025	COG2943	transferase activity, transferring hexosyl groups
EGY12_RS16030	COG5645	(Lipo)protein
EGY12_RS16045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY12_RS16055	COG0640	Transcriptional regulator
EGY12_RS16070	COG0346	lactoylglutathione lyase activity
EGY12_RS16080	COG2814	Major facilitator Superfamily
EGY12_RS16090	COG1560	Kdo2-lipid A biosynthetic process
EGY12_RS16100	COG1054	Belongs to the UPF0176 family
EGY12_RS16105	COG2353	YceI-like domain
EGY12_RS16110	COG3038	cytochrome b561
EGY12_RS16115	COG0628	permease
EGY12_RS16155	COG0418	dihydroorotase activity
EGY12_RS16160	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EGY12_RS16165	COG1530	ribonuclease E activity
EGY12_RS16175	COG0564	pseudouridine synthase activity
EGY12_RS16185	COG1399	metal-binding, possibly nucleic acid-binding protein
EGY12_RS16190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EGY12_RS16195	COG0416	fatty acid biosynthetic process
EGY12_RS16200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGY12_RS16205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EGY12_RS16215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGY12_RS16220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGY12_RS16225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EGY12_RS16230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EGY12_RS16235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EGY12_RS16240	COG0470	DNA polymerase III
EGY12_RS16245	COG0084	hydrolase, TatD family'
EGY12_RS16250	COG1263	PTS System
EGY12_RS16250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS16260	COG1321	iron dependent repressor
EGY12_RS16265	COG1914	H( )-stimulated, divalent metal cation uptake system
EGY12_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS16275	COG1733	regulation of RNA biosynthetic process
EGY12_RS16280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EGY12_RS16285	COG0537	adenosine 5'-monophosphoramidase activity
EGY12_RS16290	COG5633	Lipoprotein
EGY12_RS16295	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
EGY12_RS16300	COG0510	thiamine kinase activity
EGY12_RS16310	COG3150	esterase
EGY12_RS16315	COG1252	NADH dehydrogenase
EGY12_RS16320	COG3134	Outer membrane lipoprotein
EGY12_RS16335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY12_RS16340	COG2207	Transcriptional regulator
EGY12_RS16340	COG3708	Transcriptional regulator
EGY12_RS16360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGY12_RS16365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EGY12_RS16370	COG3381	protein complex oligomerization
EGY12_RS16375	COG2979	Protein of unknown function (DUF533)
EGY12_RS16380	COG1770	oligopeptidase
EGY12_RS16385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGY12_RS16390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY12_RS16410	COG1528	Iron-storage protein
EGY12_RS16415	COG2372	response to copper ion
EGY12_RS16420	COG1276	copper resistance
EGY12_RS16460	COG3772	lysozyme
EGY12_RS16505	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EGY12_RS16525	COG4565	transcriptional regulatory protein
EGY12_RS16530	COG3290	protein histidine kinase activity
EGY12_RS16545	COG1129	ABC transporter
EGY12_RS16550	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS16565	COG1464	Belongs to the NlpA lipoprotein family
EGY12_RS16575	COG0589	response to stress
EGY12_RS16580	COG3408	Glycogen debranching enzyme
EGY12_RS16580	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EGY12_RS16590	COG1609	Transcriptional regulator
EGY12_RS16595	COG3250	beta-galactosidase activity
EGY12_RS16600	COG2731	YhcH YjgK YiaL family protein
EGY12_RS16605	COG0531	amino acid
EGY12_RS16625	COG0740	serine-type endopeptidase activity
EGY12_RS16650	COG3121	Chaperone
EGY12_RS16665	COG0012	GTP binding
EGY12_RS16670	COG0659	secondary active sulfate transmembrane transporter activity
EGY12_RS16675	COG0193	aminoacyl-tRNA hydrolase activity
EGY12_RS16685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGY12_RS16690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EGY12_RS16695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EGY12_RS16705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EGY12_RS16710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EGY12_RS16715	COG2890	protein-(glutamine-N5) methyltransferase activity
EGY12_RS16720	COG3094	Invasion gene expression up-regulator, SirB
EGY12_RS16725	COG2912	Transglutaminase-like superfamily
EGY12_RS16730	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EGY12_RS16735	COG0659	secondary active sulfate transmembrane transporter activity
EGY12_RS16740	COG4702	Belongs to the UPF0303 family
EGY12_RS16745	COG3706	GGDEF domain
EGY12_RS16750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGY12_RS16760	COG4591	ABC-type transport system involved in lipoprotein release permease component
EGY12_RS16770	COG4591	ABC-type transport system involved in lipoprotein release permease component
EGY12_RS16795	COG1486	melibiose metabolic process
EGY12_RS16800	COG1263	PTS System
EGY12_RS16800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS16805	COG1177	transmembrane transport
EGY12_RS16825	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGY12_RS16830	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EGY12_RS16835	COG2850	peptidyl-arginine hydroxylation
EGY12_RS16845	COG0745	RESPONSE REGULATOR receiver
EGY12_RS16850	COG1397	ADP-ribosylglycohydrolase
EGY12_RS16855	COG2188	Transcriptional regulator
EGY12_RS16870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY12_RS16875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EGY12_RS16880	COG2915	High frequency lysogenization protein hflD homolog
EGY12_RS16890	COG0482	sulfurtransferase activity
EGY12_RS16905	COG1187	pseudouridine synthase activity
EGY12_RS16910	COG0538	isocitrate dehydrogenase activity
EGY12_RS16960	COG1609	Transcriptional regulator
EGY12_RS16970	COG0673	inositol 2-dehydrogenase activity
EGY12_RS17000	COG1278	Cold shock
EGY12_RS17005	COG1335	isochorismatase
EGY12_RS17010	COG0589	response to stress
EGY12_RS17015	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS17020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY12_RS17025	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS17030	COG1396	sequence-specific DNA binding
EGY12_RS17030	COG1917	Cupin 2, conserved barrel domain protein
EGY12_RS17035	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EGY12_RS17040	COG0174	glutamine synthetase
EGY12_RS17050	COG0531	amino acid
EGY12_RS17080	COG1605	Chorismate mutase
EGY12_RS17095	COG1228	amidohydrolase
EGY12_RS17105	COG0402	S-adenosylhomocysteine deaminase activity
EGY12_RS17125	COG2211	Major facilitator Superfamily
EGY12_RS17130	COG0477	Major facilitator Superfamily
EGY12_RS17135	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EGY12_RS17140	COG3493	citrate carrier protein
EGY12_RS17200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGY12_RS17200	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EGY12_RS17205	COG3008	intermembrane lipid transfer
EGY12_RS17210	COG2995	paraquat-inducible protein a
EGY12_RS17215	COG1956	GAF domain-containing protein
EGY12_RS17220	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EGY12_RS17225	COG0793	Belongs to the peptidase S41A family
EGY12_RS17230	COG0501	Belongs to the peptidase M48B family
EGY12_RS17240	COG2814	Major facilitator Superfamily
EGY12_RS17245	COG1414	Transcriptional regulator
EGY12_RS17270	COG2188	Transcriptional regulator
EGY12_RS17285	COG1823	symporter activity
EGY12_RS17290	COG1988	membrane-bound metal-dependent
EGY12_RS17295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGY12_RS17305	COG3001	Fructosamine kinase
EGY12_RS17310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGY12_RS17315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGY12_RS17320	COG1121	(ABC) transporter
EGY12_RS17325	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGY12_RS17355	COG0814	amino acid
EGY12_RS17380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EGY12_RS17390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EGY12_RS17395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EGY12_RS17405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGY12_RS17425	COG4139	cobalamin transport
EGY12_RS17430	COG0386	Belongs to the glutathione peroxidase family
EGY12_RS17435	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EGY12_RS17440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EGY12_RS17445	COG1215	transferase activity, transferring glycosyl groups
EGY12_RS17450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY12_RS17450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGY12_RS17455	COG0726	polysaccharide deacetylase
EGY12_RS17460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EGY12_RS17465	COG2076	Multidrug Resistance protein
EGY12_RS17470	COG2076	Multidrug Resistance protein
EGY12_RS17475	COG0791	NLP P60 protein
EGY12_RS17480	COG0095	Lipoate-protein ligase
EGY12_RS17500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY12_RS17505	COG4558	Periplasmic binding protein
EGY12_RS17510	COG3720	iron ion transport
EGY12_RS17525	COG0386	Belongs to the glutathione peroxidase family
EGY12_RS17530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGY12_RS17535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EGY12_RS17545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGY12_RS17545	COG0574	Belongs to the PEP-utilizing enzyme family
EGY12_RS17555	COG0628	permease
EGY12_RS17560	COG0277	FAD linked oxidase domain protein
EGY12_RS17560	COG0247	lactate metabolic process
EGY12_RS17565	COG2050	protein possibly involved in aromatic compounds catabolism
EGY12_RS17575	COG0316	Belongs to the HesB IscA family
EGY12_RS17580	COG0719	Fe-S assembly protein
EGY12_RS17585	COG0396	ATPase activity
EGY12_RS17590	COG0719	Fe-S assembly protein
EGY12_RS17595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGY12_RS17600	COG2166	iron-sulfur cluster assembly
EGY12_RS17605	COG1376	ErfK ybiS ycfS ynhG family protein
EGY12_RS17605	COG1388	LysM domain
EGY12_RS17615	COG0469	pyruvate kinase activity
EGY12_RS17640	COG0534	Mate efflux family protein
EGY12_RS17645	COG0307	riboflavin synthase, alpha
EGY12_RS17655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGY12_RS17660	COG2814	Major facilitator Superfamily
EGY12_RS17665	COG0583	DNA-binding transcription factor activity
EGY12_RS17670	COG1609	Transcriptional regulator
EGY12_RS17685	COG0791	NLP P60 protein
EGY12_RS17690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EGY12_RS17700	COG0346	lactoylglutathione lyase activity
EGY12_RS17705	COG1902	pentaerythritol trinitrate reductase activity
EGY12_RS17710	COG1309	transcriptional regulator
EGY12_RS17715	COG2194	sulfuric ester hydrolase activity
EGY12_RS17725	COG0583	DNA-binding transcription factor activity
EGY12_RS17730	COG3313	Fe-S protein
EGY12_RS17735	COG4989	oxidoreductase activity
EGY12_RS17740	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EGY12_RS17750	COG1289	transmembrane transporter activity
EGY12_RS17755	COG1566	PFAM secretion protein HlyD family protein
EGY12_RS17765	COG1846	Transcriptional regulator
EGY12_RS17770	COG3133	Outer membrane lipoprotein
EGY12_RS17775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EGY12_RS17785	COG0259	pyridoxamine-phosphate oxidase activity
EGY12_RS17790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGY12_RS17800	COG0625	glutathione transferase activity
EGY12_RS17815	COG1418	mRNA catabolic process
EGY12_RS17850	COG4122	O-methyltransferase activity
EGY12_RS17855	COG3135	benzoate transporter
EGY12_RS17860	COG1396	sequence-specific DNA binding
EGY12_RS17865	COG1505	serine-type exopeptidase activity
EGY12_RS17870	COG3104	oligopeptide transport
EGY12_RS17875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGY12_RS17885	COG4659	FMN binding
EGY12_RS17895	COG2207	Transcriptional regulator
EGY12_RS17895	COG3708	Transcriptional regulator
EGY12_RS17900	COG4656	Part of a membrane complex involved in electron transport
EGY12_RS17905	COG2878	Part of a membrane complex involved in electron transport
EGY12_RS17910	COG4657	Part of a membrane complex involved in electron transport
EGY12_RS17920	COG0673	inositol 2-dehydrogenase activity
EGY12_RS17925	COG0385	Bile acid
EGY12_RS17935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EGY12_RS17940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EGY12_RS17945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS17945	COG1263	PTS System
EGY12_RS17950	COG1609	Transcriptional regulator
EGY12_RS17965	COG0583	DNA-binding transcription factor activity
EGY12_RS17975	COG5339	Protein conserved in bacteria
EGY12_RS17995	COG0114	fumarate hydratase activity
EGY12_RS18000	COG2378	regulation of single-species biofilm formation
EGY12_RS18015	COG1472	Belongs to the glycosyl hydrolase 3 family
EGY12_RS18020	COG1649	PFAM Uncharacterised BCR, COG1649
EGY12_RS18025	COG2814	Major facilitator Superfamily
EGY12_RS18030	COG0583	DNA-binding transcription factor activity
EGY12_RS18035	COG1940	carbohydrate kinase activity
EGY12_RS18040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EGY12_RS18050	COG0789	Transcriptional regulator
EGY12_RS18080	COG0477	Major facilitator Superfamily
EGY12_RS18095	COG1742	UPF0060 membrane protein
EGY12_RS18100	COG4221	oxidoreductase activity
EGY12_RS18110	COG4772	TonB-dependent receptor
EGY12_RS18115	COG3712	iron ion homeostasis
EGY12_RS18120	COG1595	DNA-templated transcription, initiation
EGY12_RS18125	COG0402	S-adenosylhomocysteine deaminase activity
EGY12_RS18140	COG0339	signal peptide processing
EGY12_RS18145	COG2271	Major facilitator Superfamily
EGY12_RS18150	COG1335	isochorismatase
EGY12_RS18155	COG3473	Maleate cis-trans isomerase
EGY12_RS18160	COG0596	Alpha beta hydrolase
EGY12_RS18165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY12_RS18170	COG2309	aminopeptidase activity
EGY12_RS18175	COG1846	Transcriptional regulator
EGY12_RS18180	COG2080	2 iron, 2 sulfur cluster binding
EGY12_RS18185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY12_RS18185	COG2010	Cytochrome c
EGY12_RS18190	COG0583	DNA-binding transcription factor activity
EGY12_RS18230	COG0583	DNA-binding transcription factor activity
EGY12_RS18235	COG1073	alpha beta
EGY12_RS18240	COG2140	Oxalate decarboxylase
EGY12_RS18275	COG0596	Alpha beta hydrolase
EGY12_RS18330	COG2814	Major facilitator Superfamily
EGY12_RS18350	COG0768	penicillin binding
EGY12_RS18365	COG0840	transmembrane signaling receptor activity
EGY12_RS18395	COG1349	DNA-binding transcription factor activity
EGY12_RS18400	COG0673	inositol 2-dehydrogenase activity
EGY12_RS18405	COG2814	Major facilitator Superfamily
EGY12_RS18430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGY12_RS18435	COG2862	Uncharacterized protein family, UPF0114
EGY12_RS18445	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY12_RS18460	COG1064	alcohol dehydrogenase
EGY12_RS18470	COG3284	Transcriptional regulator
EGY12_RS18480	COG2814	Major facilitator Superfamily
EGY12_RS18485	COG5001	Diguanylate cyclase
EGY12_RS18485	COG3300	MHYT domain
EGY12_RS18500	COG1802	Transcriptional regulator
EGY12_RS18510	COG2267	carboxylic ester hydrolase activity
EGY12_RS18515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGY12_RS18520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY12_RS18525	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS18530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EGY12_RS18570	COG0583	DNA-binding transcription factor activity
EGY12_RS18575	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EGY12_RS18580	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS18610	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS18615	COG1802	Transcriptional regulator
EGY12_RS18620	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY12_RS18625	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS18635	COG0076	glutamate decarboxylase activity
EGY12_RS18640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EGY12_RS18645	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY12_RS18645	COG1902	pentaerythritol trinitrate reductase activity
EGY12_RS18655	COG0148	phosphopyruvate hydratase activity
EGY12_RS18665	COG1227	inorganic diphosphatase activity
EGY12_RS18670	COG3447	MASE1 domain protein
EGY12_RS18670	COG5002	protein histidine kinase activity
EGY12_RS18670	COG5001	Diguanylate cyclase
EGY12_RS18685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGY12_RS18695	COG0583	DNA-binding transcription factor activity
EGY12_RS18700	COG1063	alcohol dehydrogenase
EGY12_RS18725	COG4221	oxidoreductase activity
EGY12_RS18730	COG4221	oxidoreductase activity
EGY12_RS18745	COG1082	Xylose isomerase domain protein TIM barrel
EGY12_RS18750	COG0673	inositol 2-dehydrogenase activity
EGY12_RS18785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGY12_RS18820	COG2249	NAD(P)H dehydrogenase (quinone) activity
EGY12_RS18825	COG2249	NAD(P)H dehydrogenase (quinone) activity
EGY12_RS18830	COG1733	regulation of RNA biosynthetic process
EGY12_RS18840	COG1113	amino acid transport
EGY12_RS18845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGY12_RS18855	COG0693	protein deglycase activity
EGY12_RS18870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY12_RS18890	COG2957	Belongs to the agmatine deiminase family
EGY12_RS18895	COG0583	DNA-binding transcription factor activity
EGY12_RS18905	COG0243	molybdopterin cofactor binding
EGY12_RS18910	COG1349	DNA-binding transcription factor activity
EGY12_RS18925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGY12_RS18930	COG3192	ethanolamine utilization protein
EGY12_RS18955	COG0778	Nitroreductase
EGY12_RS18960	COG2010	Cytochrome c
EGY12_RS18960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY12_RS18965	COG2010	Cytochrome c
EGY12_RS18965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY12_RS18970	COG2080	2 iron, 2 sulfur cluster binding
EGY12_RS18980	COG1737	Transcriptional regulator
EGY12_RS18985	COG2723	6-phospho-beta-galactosidase activity
EGY12_RS18990	COG3048	D-serine ammonia-lyase activity
EGY12_RS19005	COG5507	3-demethylubiquinone-9 3-methyltransferase
EGY12_RS19010	COG2199	diguanylate cyclase activity
EGY12_RS19035	COG1196	nuclear chromosome segregation
EGY12_RS19035	COG3264	Mechanosensitive ion channel
EGY12_RS19040	COG0488	(ABC) transporter
EGY12_RS19050	COG0483	inositol monophosphate 1-phosphatase activity
EGY12_RS19055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EGY12_RS19065	COG2239	Acts as a magnesium transporter
EGY12_RS19110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGY12_RS19115	COG0697	spore germination
EGY12_RS19150	COG3158	transport of potassium into the cell
EGY12_RS19160	COG1116	anion transmembrane transporter activity
EGY12_RS19180	COG0306	phosphate transporter
EGY12_RS19205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY12_RS19225	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EGY12_RS19230	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EGY12_RS19255	COG1175	transmembrane transport
EGY12_RS19260	COG0395	ABC-type sugar transport system, permease component
EGY12_RS19265	COG3842	ATPase activity
EGY12_RS19270	COG0673	inositol 2-dehydrogenase activity
EGY12_RS19275	COG1940	carbohydrate kinase activity
EGY12_RS19280	COG1349	DNA-binding transcription factor activity
EGY12_RS19285	COG2222	sugar isomerase
EGY12_RS19300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGY12_RS19310	COG0589	response to stress
EGY12_RS19315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EGY12_RS19320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EGY12_RS19335	COG0531	amino acid
EGY12_RS19360	COG0745	RESPONSE REGULATOR receiver
EGY12_RS19365	COG2205	protein histidine kinase activity
EGY12_RS19370	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EGY12_RS19375	COG2267	carboxylic ester hydrolase activity
EGY12_RS19385	COG3591	Belongs to the peptidase S1B family
EGY12_RS19395	COG2814	Major facilitator Superfamily
EGY12_RS19400	COG1643	Atp-dependent helicase
EGY12_RS19405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EGY12_RS19415	COG3784	Protein of unknown function (DUF1318)
EGY12_RS19425	COG2911	Protein conserved in bacteria
EGY12_RS19430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY12_RS19435	COG3187	Heat shock protein
EGY12_RS19440	COG3042	response to heat
EGY12_RS19450	COG0674	pyruvate-flavodoxin oxidoreductase activity
EGY12_RS19450	COG1013	pyruvate-flavodoxin oxidoreductase activity
EGY12_RS19450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EGY12_RS19450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY12_RS19460	COG0037	tRNA processing
EGY12_RS19485	COG4166	transmembrane transport
EGY12_RS19495	COG2866	Carboxypeptidase
EGY12_RS19500	COG4948	Mandelate Racemase Muconate Lactonizing
EGY12_RS19505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EGY12_RS19515	COG3768	UPF0283 membrane protein
EGY12_RS19520	COG3106	COG3106 Predicted ATPase
EGY12_RS19530	COG1983	PspC domain protein
EGY12_RS19540	COG1842	Phage shock protein A
EGY12_RS19545	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EGY12_RS19560	COG1469	GTP cyclohydrolase I activity
EGY12_RS19575	COG4171	peptide transport system, permease
EGY12_RS19580	COG4172	Belongs to the ABC transporter superfamily
EGY12_RS19585	COG4172	Belongs to the ABC transporter superfamily
EGY12_RS19595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGY12_RS19595	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGY12_RS19610	COG0243	molybdopterin cofactor binding
EGY12_RS19615	COG0583	DNA-binding transcription factor activity
EGY12_RS19625	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EGY12_RS19630	COG0477	Major facilitator Superfamily
EGY12_RS19635	COG1473	amidohydrolase
EGY12_RS19640	COG1966	Carbon starvation protein
EGY12_RS19645	COG0859	PFAM glycosyl transferase family 9
EGY12_RS19675	COG2831	hemolysin activation secretion protein
EGY12_RS19680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EGY12_RS19685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EGY12_RS19690	COG1882	Formate acetyltransferase
EGY12_RS19695	COG1349	DNA-binding transcription factor activity
EGY12_RS19705	COG0023	Translation Initiation Factor
EGY12_RS19725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EGY12_RS19730	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EGY12_RS19735	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS19740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGY12_RS19745	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS19750	COG1129	ABC transporter
EGY12_RS19760	COG1879	ABC-type sugar transport system periplasmic component
EGY12_RS19765	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS19770	COG3958	Transketolase
EGY12_RS19775	COG3959	Transketolase, thiamine diphosphate binding domain
EGY12_RS19780	COG1349	DNA-binding transcription factor activity
EGY12_RS19785	COG0671	phosphoesterase, PA-phosphatase related
EGY12_RS19795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EGY12_RS19810	COG0583	DNA-binding transcription factor activity
EGY12_RS19825	COG0616	signal peptide processing
EGY12_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS19835	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EGY12_RS19840	COG1187	pseudouridine synthase activity
EGY12_RS19860	COG0009	L-threonylcarbamoyladenylate synthase
EGY12_RS19865	COG0613	PHP domain protein
EGY12_RS19880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGY12_RS19890	COG0133	tryptophan synthase activity
EGY12_RS19895	COG0159	tryptophan synthase activity
EGY12_RS19910	COG0727	PFAM Uncharacterised protein family (UPF0153)
EGY12_RS19925	COG2917	probably involved in intracellular septation
EGY12_RS19930	COG1607	acyl-coa hydrolase
EGY12_RS19940	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGY12_RS19945	COG2350	Protein conserved in bacteria
EGY12_RS19970	COG0783	Belongs to the Dps family
EGY12_RS19980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGY12_RS19985	COG3099	Belongs to the UPF0263 family
EGY12_RS19995	COG0444	Belongs to the ABC transporter superfamily
EGY12_RS20000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY12_RS20015	COG4166	transmembrane transport
EGY12_RS20020	COG2095	MarC family integral membrane protein
EGY12_RS20025	COG1454	alcohol dehydrogenase
EGY12_RS20025	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS20050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGY12_RS20055	COG0745	RESPONSE REGULATOR receiver
EGY12_RS20060	COG1752	Esterase of the alpha-beta hydrolase superfamily
EGY12_RS20065	COG3012	SEC-C Motif Domain Protein
EGY12_RS20070	COG0788	formyltetrahydrofolate deformylase activity
EGY12_RS20100	COG0708	Exodeoxyribonuclease III
EGY12_RS20105	COG0494	nUDIX hydrolase
EGY12_RS20115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EGY12_RS20120	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EGY12_RS20130	COG0778	Nitroreductase
EGY12_RS20135	COG0616	signal peptide processing
EGY12_RS20140	COG0252	asparaginase activity
EGY12_RS20145	COG1335	isochorismatase
EGY12_RS20155	COG3139	Protein of unknown function (DUF1315)
EGY12_RS20160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGY12_RS20175	COG3713	MltA-interacting MipA family protein
EGY12_RS20180	COG2766	serine protein kinase
EGY12_RS20185	COG2718	Belongs to the UPF0229 family
EGY12_RS20225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EGY12_RS20230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY12_RS20240	COG3443	Belongs to the bacterial solute-binding protein 9 family
EGY12_RS20245	COG2719	SpoVR family
EGY12_RS20250	COG2186	Transcriptional regulator
EGY12_RS20255	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EGY12_RS20260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EGY12_RS20270	COG2983	Belongs to the UPF0260 family
EGY12_RS20275	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY12_RS20280	COG2951	lytic endotransglycosylase activity
EGY12_RS20285	COG3100	YcgL domain-containing protein
EGY12_RS20290	COG0850	regulation of cytokinetic process
EGY12_RS20295	COG2894	cell division
EGY12_RS20300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EGY12_RS20305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EGY12_RS20310	COG0318	PFAM AMP-dependent synthetase and ligase
EGY12_RS20315	COG3065	identical protein binding
EGY12_RS20325	COG1199	ATP-dependent helicase activity
EGY12_RS20330	COG0251	oxidation-reduction process
EGY12_RS20335	COG2076	Multidrug Resistance protein
EGY12_RS20340	COG2076	Multidrug Resistance protein
EGY12_RS20345	COG0800	Aldolase
EGY12_RS20350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EGY12_RS20355	COG1737	Transcriptional regulator
EGY12_RS20360	COG0469	pyruvate kinase activity
EGY12_RS20370	COG1560	Kdo2-lipid A biosynthetic process
EGY12_RS20375	COG0739	heme binding
EGY12_RS20380	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EGY12_RS20385	COG1121	(ABC) transporter
EGY12_RS20390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGY12_RS20395	COG2255	four-way junction helicase activity
EGY12_RS20400	COG0632	four-way junction helicase activity
EGY12_RS20405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EGY12_RS20410	COG0217	transcriptional regulatory protein
EGY12_RS20415	COG0494	nUDIX hydrolase
EGY12_RS20420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGY12_RS20430	COG1335	isochorismatase
EGY12_RS20435	COG1801	Protein of unknown function DUF72
EGY12_RS20440	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EGY12_RS20445	COG2226	methyltransferase
EGY12_RS20450	COG0500	methyltransferase
EGY12_RS20455	COG0545	Peptidyl-prolyl cis-trans isomerase
EGY12_RS20465	COG3142	Participates in the control of copper homeostasis
EGY12_RS20470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EGY12_RS20475	COG3102	Protein conserved in bacteria
EGY12_RS20480	COG0018	arginyl-trna synthetase
EGY12_RS20490	COG0673	inositol 2-dehydrogenase activity
EGY12_RS20495	COG3132	Protein of unknown function, DUF480
EGY12_RS20500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY12_RS20505	COG0477	Major facilitator Superfamily
EGY12_RS20515	COG2999	glutathione oxidoreductase activity
EGY12_RS20535	COG3097	Belongs to the UPF0267 family
EGY12_RS20540	COG3141	response to X-ray
EGY12_RS20545	COG0513	Belongs to the DEAD box helicase family
EGY12_RS20555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EGY12_RS20560	COG3140	Belongs to the UPF0181 family
EGY12_RS20565	COG1216	Glycosyl transferase, family 2
EGY12_RS20575	COG0494	nUDIX hydrolase
EGY12_RS20580	COG1760	l-serine dehydratase
EGY12_RS20585	COG2200	EAL domain
EGY12_RS20590	COG1253	flavin adenine dinucleotide binding
EGY12_RS20595	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY12_RS20595	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGY12_RS20600	COG3715	PTS system
EGY12_RS20605	COG3716	PTS system mannose fructose sorbose family IID component
EGY12_RS20610	COG4811	Protein of unknown function (DUF986)
EGY12_RS20615	COG1971	Probably functions as a manganese efflux pump
EGY12_RS20620	COG2226	methyltransferase
EGY12_RS20625	COG1496	oxidoreductase activity
EGY12_RS20650	COG1113	amino acid transport
EGY12_RS20695	COG2207	Transcriptional regulator
EGY12_RS20710	COG1652	LysM domain
EGY12_RS20730	COG2988	succinylglutamate desuccinylase activity
EGY12_RS20735	COG3724	N-succinylarginine dihydrolase activity
EGY12_RS20740	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS20745	COG3138	arginine N-succinyltransferase
EGY12_RS20750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EGY12_RS20760	COG4608	Belongs to the ABC transporter superfamily
EGY12_RS20765	COG0444	Belongs to the ABC transporter superfamily
EGY12_RS20775	COG0601	transmembrane transport
EGY12_RS20785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY12_RS20790	COG1271	oxidase subunit
EGY12_RS20795	COG1294	oxidase, subunit
EGY12_RS20845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY12_RS20850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGY12_RS20855	COG2181	nitrate reductase activity
EGY12_RS20860	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EGY12_RS20865	COG1140	nitrate reductase beta subunit
EGY12_RS20870	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EGY12_RS20910	COG0489	protein tyrosine kinase activity
EGY12_RS20910	COG3206	protein involved in exopolysaccharide biosynthesis
EGY12_RS20920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGY12_RS20925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY12_RS20930	COG3710	Transcriptional regulator
EGY12_RS20935	COG2223	nitrite transmembrane transporter activity
EGY12_RS20940	COG3850	Histidine kinase
EGY12_RS20945	COG2197	response regulator
EGY12_RS20950	COG4932	domain protein
EGY12_RS20955	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EGY12_RS20970	COG4608	Belongs to the ABC transporter superfamily
EGY12_RS20975	COG0444	Belongs to the ABC transporter superfamily
EGY12_RS20980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY12_RS20985	COG0601	transmembrane transport
EGY12_RS21000	COG0583	DNA-binding transcription factor activity
EGY12_RS21005	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EGY12_RS21010	COG4572	Cation transport regulator
EGY12_RS21015	COG2375	cellular response to nickel ion
EGY12_RS21020	COG0387	Pfam Sodium calcium exchanger
EGY12_RS21030	COG1702	phosphate starvation-inducible protein PhoH
EGY12_RS21040	COG2822	iron ion transport
EGY12_RS21045	COG0672	)-iron permease
EGY12_RS21055	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EGY12_RS21055	COG0506	proline dehydrogenase activity
EGY12_RS21055	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EGY12_RS21070	COG1126	abc transporter atp-binding protein
EGY12_RS21075	COG0765	amino acid transport
EGY12_RS21080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS21085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EGY12_RS21095	COG1191	sigma factor activity
EGY12_RS21130	COG0583	DNA-binding transcription factor activity
EGY12_RS21145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGY12_RS21150	COG1677	Flagellar hook-basal body complex protein FliE
EGY12_RS21160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGY12_RS21165	COG1317	bacterial-type flagellum organization
EGY12_RS21170	COG1157	protein secretion by the type III secretion system
EGY12_RS21175	COG2882	bacterial-type flagellum organization
EGY12_RS21225	COG1256	bacterial-type flagellum assembly
EGY12_RS21260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EGY12_RS21265	COG1558	bacterial-type flagellum-dependent cell motility
EGY12_RS21270	COG1815	bacterial-type flagellum-dependent cell motility
EGY12_RS21280	COG2747	anti-sigma28 factor FlgM
EGY12_RS21285	COG3418	PFAM FlgN family protein
EGY12_RS21305	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGY12_RS21310	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGY12_RS21315	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EGY12_RS21320	COG0745	RESPONSE REGULATOR receiver
EGY12_RS21330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EGY12_RS21335	COG0840	transmembrane signaling receptor activity
EGY12_RS21340	COG0840	transmembrane signaling receptor activity
EGY12_RS21345	COG0835	chemotaxis
EGY12_RS21350	COG0643	Histidine kinase
EGY12_RS21350	COG2198	Histidine kinase
EGY12_RS21385	COG0589	response to stress
EGY12_RS21390	COG2130	NADP-dependent
EGY12_RS21395	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EGY12_RS21575	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EGY12_RS21580	COG3483	tryptophan 2,3-dioxygenase activity
EGY12_RS21585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY12_RS21595	COG3059	membrane
EGY12_RS21605	COG1609	Transcriptional regulator
EGY12_RS21630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EGY12_RS21635	COG0583	DNA-binding transcription factor activity
EGY12_RS21655	COG3781	membrane
EGY12_RS21660	COG2837	iron assimilation
EGY12_RS21685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EGY12_RS21710	COG1285	pathogenesis
EGY12_RS21720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY12_RS21725	COG0583	DNA-binding transcription factor activity
EGY12_RS21730	COG0076	glutamate decarboxylase activity
EGY12_RS21765	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS21765	COG3321	synthase
EGY12_RS21765	COG0604	alcohol dehydrogenase
EGY12_RS21775	COG0583	DNA-binding transcription factor activity
EGY12_RS21780	COG3753	Protein conserved in bacteria
EGY12_RS21785	COG2261	transglycosylase associated protein
EGY12_RS21795	COG1560	Kdo2-lipid A biosynthetic process
EGY12_RS21800	COG2764	glyoxalase bleomycin resistance protein dioxygenase
EGY12_RS21810	COG2203	Gaf domain
EGY12_RS21810	COG3706	GGDEF domain
EGY12_RS21810	COG4251	negative regulation of phosphorylation
EGY12_RS21810	COG5001	Diguanylate cyclase
EGY12_RS21820	COG1012	belongs to the aldehyde dehydrogenase family
EGY12_RS21820	COG2030	dehydratase
EGY12_RS21825	COG3396	Phenylacetate-CoA oxygenase
EGY12_RS21830	COG3460	Phenylacetate-CoA oxygenase
EGY12_RS21835	COG3396	Phenylacetate-CoA oxygenase
EGY12_RS21840	COG2151	metal-sulfur cluster biosynthetic enzyme
EGY12_RS21845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY12_RS21850	COG1024	Enoyl-CoA hydratase
EGY12_RS21855	COG1024	Enoyl-CoA hydratase
EGY12_RS21860	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGY12_RS21865	COG2050	protein possibly involved in aromatic compounds catabolism
EGY12_RS21870	COG0183	Belongs to the thiolase family
EGY12_RS21875	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EGY12_RS21880	COG3327	negative regulation of DNA-templated transcription, initiation
EGY12_RS21885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EGY12_RS21890	COG1113	amino acid transport
EGY12_RS21895	COG1448	Aminotransferase
EGY12_RS21910	COG0583	DNA-binding transcription factor activity
EGY12_RS21915	COG0625	glutathione transferase activity
EGY12_RS21955	COG0667	Aldo Keto reductase
EGY12_RS21960	COG4772	TonB-dependent receptor
EGY12_RS21965	COG4993	Dehydrogenase
EGY12_RS21980	COG0534	Mate efflux family protein
EGY12_RS22010	COG3228	Belongs to the MtfA family
EGY12_RS22020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EGY12_RS22025	COG4977	sequence-specific DNA binding
EGY12_RS22035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY12_RS22040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EGY12_RS22045	COG1116	anion transmembrane transporter activity
EGY12_RS22050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY12_RS22055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGY12_RS22070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGY12_RS22085	COG3238	Protein conserved in bacteria
EGY12_RS22090	COG1247	-acetyltransferase
EGY12_RS22110	COG0583	DNA-binding transcription factor activity
EGY12_RS22135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGY12_RS22155	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS22160	COG1169	isochorismate synthase
EGY12_RS22185	COG0471	metal ion transport
EGY12_RS22190	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EGY12_RS22200	COG3051	citrate lyase alpha subunit
EGY12_RS22205	COG2301	Belongs to the HpcH HpaI aldolase family
EGY12_RS22210	COG3052	prosthetic group binding
EGY12_RS22215	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EGY12_RS22220	COG4565	transcriptional regulatory protein
EGY12_RS22225	COG3250	beta-galactosidase activity
EGY12_RS22235	COG0300	oxidoreductase activity
EGY12_RS22240	COG2207	Transcriptional regulator
EGY12_RS22260	COG0583	DNA-binding transcription factor activity
EGY12_RS22280	COG2197	response regulator
EGY12_RS22290	COG1121	(ABC) transporter
EGY12_RS22295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY12_RS22310	COG2814	Major facilitator Superfamily
EGY12_RS22335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EGY12_RS22350	COG2070	2-Nitropropane dioxygenase
EGY12_RS22370	COG2271	Major facilitator Superfamily
EGY12_RS22400	COG0411	ABC transporter
EGY12_RS22450	COG0583	DNA-binding transcription factor activity
EGY12_RS22460	COG0456	acetyltransferase
EGY12_RS22475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGY12_RS22480	COG0156	8-amino-7-oxononanoate synthase activity
EGY12_RS22485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EGY12_RS22490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EGY12_RS22495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EGY12_RS22500	COG2244	polysaccharide biosynthetic process
EGY12_RS22510	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EGY12_RS22515	COG0795	lipopolysaccharide-transporting ATPase activity
EGY12_RS22560	COG0583	DNA-binding transcription factor activity
EGY12_RS22590	COG1609	Transcriptional regulator
EGY12_RS22600	COG3623	hexulose-6-phosphate isomerase
EGY12_RS22605	COG1070	Carbohydrate kinase
EGY12_RS22610	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS22620	COG1879	ABC-type sugar transport system periplasmic component
EGY12_RS22625	COG1063	alcohol dehydrogenase
EGY12_RS22635	COG1473	amidohydrolase
EGY12_RS22640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY12_RS22645	COG2926	Belongs to the UPF0265 family
EGY12_RS22650	COG1289	transmembrane transporter activity
EGY12_RS22655	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGY12_RS22680	COG2925	Exonuclease
EGY12_RS22685	COG0531	amino acid
EGY12_RS22695	COG0174	glutamine synthetase
EGY12_RS22700	COG1917	Cupin 2, conserved barrel domain protein
EGY12_RS22700	COG1396	sequence-specific DNA binding
EGY12_RS22705	COG1129	ABC transporter
EGY12_RS22710	COG1172	Belongs to the binding-protein-dependent transport system permease family
EGY12_RS22715	COG4771	TonB-dependent receptor
EGY12_RS22730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY12_RS22740	COG0833	amino acid
EGY12_RS22745	COG0583	DNA-binding transcription factor activity
EGY12_RS22755	COG2855	membrane
EGY12_RS22760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EGY12_RS22765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGY12_RS22765	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EGY12_RS22765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGY12_RS22770	COG1105	Belongs to the carbohydrate kinase PfkB family
EGY12_RS22785	COG0494	nUDIX hydrolase
EGY12_RS22790	COG3005	denitrification pathway
EGY12_RS22795	COG0243	molybdopterin cofactor binding
EGY12_RS22815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGY12_RS22820	COG1312	Catalyzes the dehydration of D-mannonate
EGY12_RS22825	COG0246	Mannitol dehydrogenase
EGY12_RS22835	COG0523	cobalamin synthesis protein
EGY12_RS22840	COG0671	phosphoesterase, PA-phosphatase related
EGY12_RS22850	COG0791	NLP P60 protein
EGY12_RS22855	COG2200	EAL domain
EGY12_RS22860	COG4166	transmembrane transport
EGY12_RS22865	COG4174	ABC transporter (Permease)
EGY12_RS22870	COG4239	(ABC) transporter, permease
EGY12_RS22875	COG4172	Belongs to the ABC transporter superfamily
EGY12_RS22885	COG2814	Major facilitator Superfamily
EGY12_RS22890	COG1187	pseudouridine synthase activity
EGY12_RS22895	COG1061	Type III restriction enzyme res subunit
EGY12_RS22900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EGY12_RS22905	COG3081	Nucleoid-associated protein
EGY12_RS22910	COG3082	Protein of unknown function (DUF1414)
EGY12_RS22915	COG3083	sulfuric ester hydrolase activity
EGY12_RS22975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EGY12_RS22995	COG2755	lipolytic protein G-D-S-L family
EGY12_RS22995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGY12_RS23010	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY12_RS23025	COG0346	lactoylglutathione lyase activity
EGY12_RS23040	COG2223	nitrite transmembrane transporter activity
EGY12_RS23045	COG0642	Histidine kinase
EGY12_RS23045	COG2198	Histidine kinase
EGY12_RS23050	COG2197	response regulator
EGY12_RS23055	COG0784	Response regulator, receiver
EGY12_RS23055	COG2205	protein histidine kinase activity
EGY12_RS23065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EGY12_RS23070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGY12_RS23080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY12_RS23105	COG0814	amino acid
EGY12_RS23120	COG0318	PFAM AMP-dependent synthetase and ligase
EGY12_RS23130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EGY12_RS23135	COG0596	Alpha beta hydrolase
EGY12_RS23140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EGY12_RS23145	COG4575	ribosome binding
EGY12_RS23150	COG1028	Short-chain dehydrogenase reductase Sdr
EGY12_RS23165	COG0583	DNA-binding transcription factor activity
EGY12_RS23180	COG1007	ATP synthesis coupled electron transport
EGY12_RS23185	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY12_RS23190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EGY12_RS23195	COG0713	ATP synthesis coupled electron transport
EGY12_RS23200	COG0839	Belongs to the complex I subunit 6 family
EGY12_RS23210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EGY12_RS23215	COG1034	ATP synthesis coupled electron transport
EGY12_RS23230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY12_RS23230	COG0649	NAD binding
EGY12_RS23235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY12_RS23240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY12_RS23245	COG0583	DNA-binding transcription factor activity
EGY12_RS23250	COG0436	Aminotransferase
EGY12_RS23255	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EGY12_RS23260	COG0471	metal ion transport
EGY12_RS23260	COG0490	domain, Protein
EGY12_RS23265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGY12_RS23270	COG3013	Belongs to the UPF0304 family
EGY12_RS23275	COG3092	negative regulation of chromosome organization
EGY12_RS23280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGY12_RS23285	COG0280	phosphate acetyltransferase
EGY12_RS23285	COG0857	belongs to the CobB CobQ family
EGY12_RS23290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EGY12_RS23295	COG3959	Transketolase, thiamine diphosphate binding domain
EGY12_RS23300	COG3037	sugar-specific permease SgaT UlaA
EGY12_RS23310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system