locus-tag	class	description
SSYIS1_RS00005	COG0445	tRNA wobble uridine modification
SSYIS1_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
SSYIS1_RS00015	COG3312	ion transport
SSYIS1_RS00030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SSYIS1_RS00035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SSYIS1_RS00040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SSYIS1_RS00045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SSYIS1_RS00050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SSYIS1_RS00055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SSYIS1_RS00060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SSYIS1_RS00100	COG0439	Biotin carboxylase
SSYIS1_RS00105	COG0511	ligase activity, forming carbon-carbon bonds
SSYIS1_RS00110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SSYIS1_RS00120	COG3328	transposase activity
SSYIS1_RS00160	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS00180	COG3609	addiction module antidote protein, CC2985 family
SSYIS1_RS00195	COG2105	PFAM AIG2 family protein
SSYIS1_RS00200	COG2911	Protein conserved in bacteria
SSYIS1_RS00205	COG0729	surface antigen
SSYIS1_RS00210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSYIS1_RS00250	COG2974	May be involved in recombination
SSYIS1_RS00255	COG3123	guanosine phosphorylase activity
SSYIS1_RS00275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SSYIS1_RS00315	COG0560	Phosphoserine phosphatase
SSYIS1_RS00320	COG3726	membrane protein affecting hemolysin expression
SSYIS1_RS00330	COG0813	purine-nucleoside phosphorylase activity
SSYIS1_RS00335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SSYIS1_RS00340	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SSYIS1_RS00345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SSYIS1_RS00350	COG0084	hydrolase, TatD family'
SSYIS1_RS00355	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SSYIS1_RS00375	COG0456	acetyltransferase
SSYIS1_RS00380	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
SSYIS1_RS00385	COG2813	Specifically methylates the guanine in position
SSYIS1_RS00415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SSYIS1_RS00420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSYIS1_RS00430	COG1489	DNA binding
SSYIS1_RS00440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SSYIS1_RS00450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SSYIS1_RS00455	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SSYIS1_RS00465	COG3151	Protein conserved in bacteria
SSYIS1_RS00475	COG1538	Outer membrane efflux protein
SSYIS1_RS00480	COG5463	Belongs to the UPF0441 family
SSYIS1_RS00485	COG0754	glutathionylspermidine amidase activity
SSYIS1_RS00490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SSYIS1_RS00495	COG2960	long-chain fatty acid transporting porin activity
SSYIS1_RS00500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SSYIS1_RS00500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SSYIS1_RS00510	COG3025	triphosphatase activity
SSYIS1_RS00515	COG4991	sh3 domain protein
SSYIS1_RS00520	COG0617	tRNA 3'-terminal CCA addition
SSYIS1_RS00525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SSYIS1_RS00530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SSYIS1_RS00535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SSYIS1_RS00540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SSYIS1_RS00545	COG0358	DNA primase activity
SSYIS1_RS00585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SSYIS1_RS00590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SSYIS1_RS00595	COG1872	DUF167
SSYIS1_RS00600	COG0762	integral membrane protein
SSYIS1_RS00605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SSYIS1_RS00625	COG3074	FtsZ-dependent cytokinesis
SSYIS1_RS00630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SSYIS1_RS00640	COG2814	Major facilitator Superfamily
SSYIS1_RS00650	COG0312	modulator of DNA gyrase
SSYIS1_RS00660	COG1530	ribonuclease E activity
SSYIS1_RS00670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SSYIS1_RS00675	COG1792	Involved in formation and maintenance of cell shape
SSYIS1_RS00680	COG1077	Cell shape determining protein MreB Mrl
SSYIS1_RS00710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SSYIS1_RS00715	COG1393	Belongs to the ArsC family
SSYIS1_RS00720	COG4783	chaperone-mediated protein folding
SSYIS1_RS00725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SSYIS1_RS00740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSYIS1_RS00745	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SSYIS1_RS00750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SSYIS1_RS00770	COG1876	peptidase activity
SSYIS1_RS00775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSYIS1_RS00780	COG1393	Belongs to the ArsC family
SSYIS1_RS00815	COG0588	phosphoglycerate mutase activity
SSYIS1_RS00835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SSYIS1_RS00845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SSYIS1_RS00865	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
SSYIS1_RS00870	COG2885	chlorophyll binding
SSYIS1_RS00875	COG0823	Involved in the tonB-independent uptake of proteins
SSYIS1_RS00880	COG3064	Membrane
SSYIS1_RS00880	COG3064	Membrane
SSYIS1_RS00885	COG0848	biopolymer transport protein
SSYIS1_RS00890	COG0811	peptide transport
SSYIS1_RS00895	COG0824	Thioesterase
SSYIS1_RS00905	COG4890	Cyd operon protein YbgT
SSYIS1_RS00910	COG1294	oxidase, subunit
SSYIS1_RS00955	COG2842	Transposition protein
SSYIS1_RS01020	COG3023	N-Acetylmuramoyl-L-alanine amidase
SSYIS1_RS01070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SSYIS1_RS01075	COG0735	belongs to the Fur family
SSYIS1_RS01090	COG0596	Alpha beta hydrolase
SSYIS1_RS01100	COG0033	Phosphoglucomutase
SSYIS1_RS01105	COG3272	Protein of unknown function (DUF1722)
SSYIS1_RS01110	COG0415	Belongs to the DNA photolyase family
SSYIS1_RS01115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SSYIS1_RS01130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SSYIS1_RS01140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SSYIS1_RS01145	COG0567	Dehydrogenase, E1 component
SSYIS1_RS01150	COG0508	dehydrogenase complex catalyzes the overall conversion of
SSYIS1_RS01155	COG0045	succinate-CoA ligase (ADP-forming) activity
SSYIS1_RS01160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SSYIS1_RS01210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SSYIS1_RS01250	COG2837	iron assimilation
SSYIS1_RS01265	COG1285	pathogenesis
SSYIS1_RS01325	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS01340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SSYIS1_RS01350	COG1702	phosphate starvation-inducible protein PhoH
SSYIS1_RS01355	COG0387	Pfam Sodium calcium exchanger
SSYIS1_RS01375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SSYIS1_RS01380	COG3138	arginine N-succinyltransferase
SSYIS1_RS01390	COG3724	N-succinylarginine dihydrolase activity
SSYIS1_RS01425	COG0746	molybdenum cofactor guanylyltransferase activity
SSYIS1_RS01435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SSYIS1_RS01440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SSYIS1_RS01445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSYIS1_RS01445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSYIS1_RS01450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SSYIS1_RS01455	COG3328	transposase activity
SSYIS1_RS01465	COG2353	YceI-like domain
SSYIS1_RS01470	COG1054	Belongs to the UPF0176 family
SSYIS1_RS01505	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
SSYIS1_RS01510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SSYIS1_RS01515	COG0540	Belongs to the ATCase OTCase family
SSYIS1_RS01550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SSYIS1_RS01550	COG1328	CTP reductase activity
SSYIS1_RS01560	COG0741	lytic transglycosylase activity
SSYIS1_RS01635	COG3121	Chaperone
SSYIS1_RS01645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SSYIS1_RS01660	COG0513	Belongs to the DEAD box helicase family
SSYIS1_RS01690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSYIS1_RS01690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSYIS1_RS01715	COG0006	proline dipeptidase activity
SSYIS1_RS01760	COG0010	Belongs to the arginase family
SSYIS1_RS01765	COG1187	pseudouridine synthase activity
SSYIS1_RS01785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SSYIS1_RS01820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SSYIS1_RS01825	COG1678	Uncharacterized ACR, COG1678
SSYIS1_RS01830	COG0189	ligase activity
SSYIS1_RS01850	COG1560	Kdo2-lipid A biosynthetic process
SSYIS1_RS01885	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SSYIS1_RS01895	COG3034	peptidoglycan biosynthetic process
SSYIS1_RS01915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SSYIS1_RS01920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SSYIS1_RS01955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SSYIS1_RS01980	COG0018	arginyl-trna synthetase
SSYIS1_RS01985	COG3102	Protein conserved in bacteria
SSYIS1_RS01990	COG3142	Participates in the control of copper homeostasis
SSYIS1_RS01995	COG0500	methyltransferase
SSYIS1_RS02000	COG2226	methyltransferase
SSYIS1_RS02005	COG1801	Protein of unknown function DUF72
SSYIS1_RS02010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SSYIS1_RS02015	COG0494	nUDIX hydrolase
SSYIS1_RS02020	COG0217	transcriptional regulatory protein
SSYIS1_RS02025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SSYIS1_RS02030	COG0632	four-way junction helicase activity
SSYIS1_RS02035	COG2255	four-way junction helicase activity
SSYIS1_RS02040	COG0739	heme binding
SSYIS1_RS02045	COG1560	Kdo2-lipid A biosynthetic process
SSYIS1_RS02055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SSYIS1_RS02070	COG1214	PFAM Peptidase M22, glycoprotease
SSYIS1_RS02075	COG3065	identical protein binding
SSYIS1_RS02090	COG0187	DNA topoisomerase II activity
SSYIS1_RS02095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SSYIS1_RS02100	COG0592	DNA-directed DNA polymerase activity
SSYIS1_RS02105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SSYIS1_RS02110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SSYIS1_RS02115	COG0594	ribonuclease P activity
SSYIS1_RS02120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SSYIS1_RS02125	COG0706	membrane insertase activity
SSYIS1_RS02130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SSYIS1_RS02140	COG2879	small protein
SSYIS1_RS02195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SSYIS1_RS02200	COG0085	RNA polymerase activity
SSYIS1_RS02205	COG0222	ribosome binding
SSYIS1_RS02210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SSYIS1_RS02215	COG0081	regulation of translation
SSYIS1_RS02225	COG0250	Participates in transcription elongation, termination and antitermination
SSYIS1_RS02235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SSYIS1_RS02265	COG1072	(Pantothenic acid kinase))
SSYIS1_RS02275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SSYIS1_RS02310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SSYIS1_RS02315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SSYIS1_RS02325	COG1309	transcriptional regulator
SSYIS1_RS02330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSYIS1_RS02350	COG0165	Argininosuccinate lyase
SSYIS1_RS02355	COG0137	argininosuccinate synthase activity
SSYIS1_RS02360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SSYIS1_RS02390	COG2926	Belongs to the UPF0265 family
SSYIS1_RS02420	COG1388	LysM domain
SSYIS1_RS02420	COG0741	lytic transglycosylase activity
SSYIS1_RS02425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSYIS1_RS02430	COG2226	methyltransferase
SSYIS1_RS02435	COG0328	RNA-DNA hybrid ribonuclease activity
SSYIS1_RS02440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SSYIS1_RS02455	COG3550	peptidyl-serine autophosphorylation
SSYIS1_RS02475	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS02490	COG3397	chitin binding
SSYIS1_RS02525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SSYIS1_RS02530	COG3150	esterase
SSYIS1_RS02535	COG0187	DNA topoisomerase II activity
SSYIS1_RS02545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SSYIS1_RS02550	COG5007	Belongs to the BolA IbaG family
SSYIS1_RS02555	COG3113	response to antibiotic
SSYIS1_RS02560	COG2854	intermembrane phospholipid transfer
SSYIS1_RS02565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SSYIS1_RS02570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SSYIS1_RS02575	COG1127	ABC transporter
SSYIS1_RS02590	COG0517	IMP dehydrogenase activity
SSYIS1_RS02590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SSYIS1_RS02595	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SSYIS1_RS02600	COG3117	lipopolysaccharide transmembrane transporter activity
SSYIS1_RS02605	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SSYIS1_RS02610	COG1137	ATPase activity
SSYIS1_RS02615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SSYIS1_RS02630	COG1660	Displays ATPase and GTPase activities
SSYIS1_RS02635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSYIS1_RS02650	COG0012	GTP binding
SSYIS1_RS02655	COG0193	aminoacyl-tRNA hydrolase activity
SSYIS1_RS02665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SSYIS1_RS02670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SSYIS1_RS02675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
SSYIS1_RS02690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SSYIS1_RS02695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SSYIS1_RS02700	COG2890	protein-(glutamine-N5) methyltransferase activity
SSYIS1_RS02715	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SSYIS1_RS02800	COG3058	Necessary for formate dehydrogenase activity
SSYIS1_RS02805	COG2864	formate dehydrogenase
SSYIS1_RS02820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SSYIS1_RS02825	COG1045	serine acetyltransferase
SSYIS1_RS02830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SSYIS1_RS02835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SSYIS1_RS02840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SSYIS1_RS02845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SSYIS1_RS02850	COG4942	peptidase
SSYIS1_RS02860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SSYIS1_RS02865	COG0859	PFAM glycosyl transferase family 9
SSYIS1_RS02870	COG0859	PFAM glycosyl transferase family 9
SSYIS1_RS02885	COG1442	glycosyl transferase family 8
SSYIS1_RS02900	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SSYIS1_RS02905	COG2943	transferase activity, transferring hexosyl groups
SSYIS1_RS02920	COG1560	Kdo2-lipid A biosynthetic process
SSYIS1_RS02940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SSYIS1_RS02945	COG2867	negative regulation of translational initiation
SSYIS1_RS02950	COG2914	Belongs to the UPF0125 (RnfH) family
SSYIS1_RS02960	COG0497	DNA recombination
SSYIS1_RS02965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SSYIS1_RS02970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SSYIS1_RS02975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SSYIS1_RS02985	COG0513	Belongs to the DEAD box helicase family
SSYIS1_RS02990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SSYIS1_RS02995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SSYIS1_RS03015	COG3086	response to oxidative stress
SSYIS1_RS03020	COG0481	GTPase activity
SSYIS1_RS03030	COG0571	ribonuclease III activity
SSYIS1_RS03035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SSYIS1_RS03040	COG1381	Involved in DNA repair and RecF pathway recombination
SSYIS1_RS03050	COG0736	holo-[acyl-carrier-protein] synthase activity
SSYIS1_RS03055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SSYIS1_RS03080	COG0671	phosphoesterase, PA-phosphatase related
SSYIS1_RS03085	COG0814	amino acid
SSYIS1_RS03095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SSYIS1_RS03120	COG0131	Imidazoleglycerol-phosphate dehydratase
SSYIS1_RS03120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SSYIS1_RS03130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SSYIS1_RS03140	COG0438	transferase activity, transferring glycosyl groups
SSYIS1_RS03160	COG0569	domain protein
SSYIS1_RS03170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SSYIS1_RS03175	COG0242	peptide deformylase activity
SSYIS1_RS03195	COG0009	L-threonylcarbamoyladenylate synthase
SSYIS1_RS03200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SSYIS1_RS03205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SSYIS1_RS03235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SSYIS1_RS03250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSYIS1_RS03255	COG2814	Major facilitator Superfamily
SSYIS1_RS03260	COG1566	PFAM secretion protein HlyD family protein
SSYIS1_RS03280	COG4176	ABC-type proline glycine betaine transport system permease component
SSYIS1_RS03285	COG4175	Glycine betaine
SSYIS1_RS03290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SSYIS1_RS03305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SSYIS1_RS03335	COG0351	phosphomethylpyrimidine kinase
SSYIS1_RS03375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SSYIS1_RS03380	COG1067	ATP-dependent peptidase activity
SSYIS1_RS03405	COG3070	regulator of competence-specific genes
SSYIS1_RS03410	COG3304	Inner membrane component domain
SSYIS1_RS03420	COG1803	Methylglyoxal synthase
SSYIS1_RS03455	COG3785	DNA binding
SSYIS1_RS03465	COG2920	part of a sulfur-relay system
SSYIS1_RS03480	COG3036	rescue of stalled ribosome
SSYIS1_RS03485	COG0789	Transcriptional regulator
SSYIS1_RS03490	COG0203	ribosomal protein L17
SSYIS1_RS03495	COG0202	RNA polymerase activity
SSYIS1_RS03500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SSYIS1_RS03505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SSYIS1_RS03510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SSYIS1_RS03515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SSYIS1_RS03520	COG0201	protein transport
SSYIS1_RS03535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SSYIS1_RS03600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SSYIS1_RS03605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SSYIS1_RS03610	COG0089	rRNA binding
SSYIS1_RS03615	COG0088	Forms part of the polypeptide exit tunnel
SSYIS1_RS03620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SSYIS1_RS03625	COG0051	transcription antitermination factor activity, RNA binding
SSYIS1_RS03630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SSYIS1_RS03635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SSYIS1_RS03640	COG0049	tRNA binding
SSYIS1_RS03645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SSYIS1_RS03650	COG2168	tRNA wobble position uridine thiolation
SSYIS1_RS03655	COG2923	Belongs to the DsrF TusC family
SSYIS1_RS03660	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SSYIS1_RS03670	COG0545	Peptidyl-prolyl cis-trans isomerase
SSYIS1_RS03680	COG1047	Peptidyl-prolyl cis-trans
SSYIS1_RS03685	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
SSYIS1_RS03695	COG2249	NAD(P)H dehydrogenase (quinone) activity
SSYIS1_RS03725	COG3539	Fimbrial protein
SSYIS1_RS03735	COG3100	YcgL domain-containing protein
SSYIS1_RS03740	COG0850	regulation of cytokinetic process
SSYIS1_RS03745	COG2894	cell division
SSYIS1_RS03750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SSYIS1_RS03765	COG4619	ABC transporter
SSYIS1_RS03775	COG2610	gluconate transmembrane transporter activity
SSYIS1_RS03780	COG3265	gluconokinase activity
SSYIS1_RS03785	COG2095	MarC family integral membrane protein
SSYIS1_RS03790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SSYIS1_RS03805	COG0705	Rhomboid family
SSYIS1_RS03810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SSYIS1_RS03820	COG0316	Belongs to the HesB IscA family
SSYIS1_RS03820	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SSYIS1_RS03825	COG1040	competence protein
SSYIS1_RS03830	COG2267	carboxylic ester hydrolase activity
SSYIS1_RS03845	COG1918	ferrous iron import across plasma membrane
SSYIS1_RS03850	COG2183	response to ionizing radiation
SSYIS1_RS03855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SSYIS1_RS03860	COG0484	heat shock protein binding
SSYIS1_RS03880	COG1487	ribonuclease activity
SSYIS1_RS03895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SSYIS1_RS03900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SSYIS1_RS03905	COG0494	nUDIX hydrolase
SSYIS1_RS03940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SSYIS1_RS03945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SSYIS1_RS03980	COG1021	2,3-dihydroxybenzoate-AMP ligase
SSYIS1_RS04010	COG2814	Major facilitator Superfamily
SSYIS1_RS04015	COG0738	Major facilitator superfamily
SSYIS1_RS04025	COG0433	COG0433 Predicted ATPase
SSYIS1_RS04040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SSYIS1_RS04045	COG3954	Phosphoribulokinase
SSYIS1_RS04050	COG3089	Belongs to the UPF0270 family
SSYIS1_RS04070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SSYIS1_RS04075	COG2175	clavaminate synthase activity
SSYIS1_RS04100	COG3561	AntA/AntB antirepressor
SSYIS1_RS04135	COG0582	viral genome integration into host DNA
SSYIS1_RS04140	COG2925	Exonuclease
SSYIS1_RS04145	COG0531	amino acid
SSYIS1_RS04155	COG0833	amino acid
SSYIS1_RS04160	COG0583	DNA-binding transcription factor activity
SSYIS1_RS04170	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SSYIS1_RS04195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SSYIS1_RS04225	COG0740	serine-type endopeptidase activity
SSYIS1_RS04230	COG4695	Portal protein
SSYIS1_RS04235	COG4626	Terminase
SSYIS1_RS04235	COG1802	Transcriptional regulator
SSYIS1_RS04265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SSYIS1_RS04275	COG3768	UPF0283 membrane protein
SSYIS1_RS04280	COG3106	COG3106 Predicted ATPase
SSYIS1_RS04290	COG1983	PspC domain protein
SSYIS1_RS04300	COG1842	Phage shock protein A
SSYIS1_RS04305	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SSYIS1_RS04320	COG0793	Belongs to the peptidase S41A family
SSYIS1_RS04325	COG0501	Belongs to the peptidase M48B family
SSYIS1_RS04340	COG1988	membrane-bound metal-dependent
SSYIS1_RS04345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSYIS1_RS04350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSYIS1_RS04355	COG1121	(ABC) transporter
SSYIS1_RS04360	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSYIS1_RS04375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SSYIS1_RS04385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SSYIS1_RS04400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SSYIS1_RS04410	COG0776	regulation of translation
SSYIS1_RS04420	COG1215	transferase activity, transferring glycosyl groups
SSYIS1_RS04435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SSYIS1_RS04440	COG2076	Multidrug Resistance protein
SSYIS1_RS04465	COG3328	transposase activity
SSYIS1_RS04490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SSYIS1_RS04495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SSYIS1_RS04515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSYIS1_RS04530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SSYIS1_RS04535	COG0326	Molecular chaperone. Has ATPase activity
SSYIS1_RS04540	COG0563	adenylate kinase activity
SSYIS1_RS04550	COG2610	gluconate transmembrane transporter activity
SSYIS1_RS04560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SSYIS1_RS04565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SSYIS1_RS04565	COG4651	solute:proton antiporter activity
SSYIS1_RS04590	COG0330	HflC and HflK could
SSYIS1_RS04605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SSYIS1_RS04610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SSYIS1_RS04615	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SSYIS1_RS04620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SSYIS1_RS04625	COG0215	cysteine-tRNA ligase activity
SSYIS1_RS04660	COG1956	GAF domain-containing protein
SSYIS1_RS04700	COG0625	glutathione transferase activity
SSYIS1_RS04710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SSYIS1_RS04720	COG4659	FMN binding
SSYIS1_RS04735	COG2878	Part of a membrane complex involved in electron transport
SSYIS1_RS04740	COG4657	Part of a membrane complex involved in electron transport
SSYIS1_RS04745	COG0385	Bile acid
SSYIS1_RS04765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SSYIS1_RS04775	COG2983	Belongs to the UPF0260 family
SSYIS1_RS04780	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SSYIS1_RS04815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SSYIS1_RS04820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSYIS1_RS04825	COG3139	Protein of unknown function (DUF1315)
SSYIS1_RS04830	COG0252	asparaginase activity
SSYIS1_RS04835	COG0616	signal peptide processing
SSYIS1_RS04850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SSYIS1_RS04875	COG0788	formyltetrahydrofolate deformylase activity
SSYIS1_RS04885	COG0745	RESPONSE REGULATOR receiver
SSYIS1_RS04890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SSYIS1_RS04920	COG0564	pseudouridine synthase activity
SSYIS1_RS04930	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SSYIS1_RS04940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SSYIS1_RS04945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SSYIS1_RS04960	COG0602	queuosine metabolic process
SSYIS1_RS04965	COG4372	Transposase
SSYIS1_RS04970	COG4372	Transposase
SSYIS1_RS04980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SSYIS1_RS04990	COG0720	synthase
SSYIS1_RS05000	COG0602	queuosine metabolic process
SSYIS1_RS05005	COG4372	Transposase
SSYIS1_RS05010	COG4372	Transposase
SSYIS1_RS05020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SSYIS1_RS05035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SSYIS1_RS05040	COG0175	sulfate reduction
SSYIS1_RS05070	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SSYIS1_RS05075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SSYIS1_RS05080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SSYIS1_RS05085	COG0585	pseudouridine synthase activity
SSYIS1_RS05090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SSYIS1_RS05095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SSYIS1_RS05100	COG1388	LysM domain
SSYIS1_RS05100	COG4942	peptidase
SSYIS1_RS05110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SSYIS1_RS05155	COG0561	phosphatase activity
SSYIS1_RS05160	COG2706	6-phosphogluconolactonase activity
SSYIS1_RS05190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SSYIS1_RS05215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SSYIS1_RS05230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SSYIS1_RS05305	COG4178	(ABC) transporter
SSYIS1_RS05325	COG1595	DNA-templated transcription, initiation
SSYIS1_RS05345	COG0745	RESPONSE REGULATOR receiver
SSYIS1_RS05395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SSYIS1_RS05420	COG1470	cell adhesion involved in biofilm formation
SSYIS1_RS05420	COG1388	LysM domain
SSYIS1_RS05425	COG1388	LysM domain
SSYIS1_RS05425	COG1470	cell adhesion involved in biofilm formation
SSYIS1_RS05460	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SSYIS1_RS05525	COG1124	(ABC) transporter
SSYIS1_RS05555	COG1132	(ABC) transporter
SSYIS1_RS05630	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SSYIS1_RS05710	COG3299	homolog of phage Mu protein gp47
SSYIS1_RS05715	COG3778	Protein conserved in bacteria
SSYIS1_RS05750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SSYIS1_RS05765	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS05815	COG0538	isocitrate dehydrogenase activity
SSYIS1_RS05820	COG1187	pseudouridine synthase activity
SSYIS1_RS05825	COG0482	sulfurtransferase activity
SSYIS1_RS05830	COG2915	High frequency lysogenization protein hflD homolog
SSYIS1_RS05835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SSYIS1_RS05840	COG0745	RESPONSE REGULATOR receiver
SSYIS1_RS05870	COG1177	transmembrane transport
SSYIS1_RS05885	COG4591	ABC-type transport system involved in lipoprotein release permease component
SSYIS1_RS05895	COG4591	ABC-type transport system involved in lipoprotein release permease component
SSYIS1_RS05900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SSYIS1_RS05910	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS05930	COG0322	excinuclease ABC activity
SSYIS1_RS05950	COG0346	lactoylglutathione lyase activity
SSYIS1_RS05955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SSYIS1_RS05960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SSYIS1_RS05965	COG0791	NLP P60 protein
SSYIS1_RS05975	COG1609	Transcriptional regulator
SSYIS1_RS05985	COG0307	riboflavin synthase, alpha
SSYIS1_RS06000	COG0469	pyruvate kinase activity
SSYIS1_RS06005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SSYIS1_RS06015	COG0396	ATPase activity
SSYIS1_RS06020	COG0719	Fe-S assembly protein
SSYIS1_RS06025	COG0316	Belongs to the HesB IscA family
SSYIS1_RS06030	COG2050	protein possibly involved in aromatic compounds catabolism
SSYIS1_RS06070	COG1253	flavin adenine dinucleotide binding
SSYIS1_RS06075	COG2982	Protein involved in outer membrane biogenesis
SSYIS1_RS06080	COG0717	Belongs to the dCTP deaminase family
SSYIS1_RS06085	COG0572	uridine kinase
SSYIS1_RS06090	COG0489	protein tyrosine kinase activity
SSYIS1_RS06095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSYIS1_RS06095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSYIS1_RS06100	COG1380	Effector of murein hydrolase LrgA
SSYIS1_RS06105	COG1346	cytolysis
SSYIS1_RS06110	COG0295	cytidine deaminase activity
SSYIS1_RS06115	COG0281	malic enzyme
SSYIS1_RS06120	COG2949	membrane
SSYIS1_RS06125	COG2311	Membrane
SSYIS1_RS06130	COG0302	gtp cyclohydrolase
SSYIS1_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSYIS1_RS06160	COG0247	lactate metabolic process
SSYIS1_RS06160	COG0277	FAD linked oxidase domain protein
SSYIS1_RS06165	COG0628	permease
SSYIS1_RS06185	COG3720	iron ion transport
SSYIS1_RS06345	COG0616	signal peptide processing
SSYIS1_RS06350	COG1028	Short-chain dehydrogenase reductase Sdr
SSYIS1_RS06355	COG1187	pseudouridine synthase activity
SSYIS1_RS06360	COG0009	L-threonylcarbamoyladenylate synthase
SSYIS1_RS06390	COG0133	tryptophan synthase activity
SSYIS1_RS06415	COG2917	probably involved in intracellular septation
SSYIS1_RS06425	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SSYIS1_RS06430	COG2350	Protein conserved in bacteria
SSYIS1_RS06465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSYIS1_RS06470	COG0444	Belongs to the ABC transporter superfamily
SSYIS1_RS06480	COG3099	Belongs to the UPF0263 family
SSYIS1_RS06485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SSYIS1_RS06505	COG4772	TonB-dependent receptor
SSYIS1_RS06515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSYIS1_RS06520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSYIS1_RS06525	COG1120	ATPase activity
SSYIS1_RS06535	COG1595	DNA-templated transcription, initiation
SSYIS1_RS06540	COG0148	phosphopyruvate hydratase activity
SSYIS1_RS06545	COG0504	CTP synthase activity
SSYIS1_RS06550	COG3956	TIGRFAM MazG family protein
SSYIS1_RS06555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SSYIS1_RS06570	COG1470	cell adhesion involved in biofilm formation
SSYIS1_RS06570	COG1388	LysM domain
SSYIS1_RS06575	COG1470	cell adhesion involved in biofilm formation
SSYIS1_RS06575	COG1388	LysM domain
SSYIS1_RS06580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SSYIS1_RS06585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SSYIS1_RS06590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SSYIS1_RS06595	COG0316	Belongs to the HesB IscA family
SSYIS1_RS06615	COG4969	Belongs to the N-Me-Phe pilin family
SSYIS1_RS06620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SSYIS1_RS06640	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
SSYIS1_RS06645	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SSYIS1_RS06650	COG0494	nUDIX hydrolase
SSYIS1_RS06655	COG0653	protein targeting
SSYIS1_RS06675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SSYIS1_RS06680	COG0849	cell division
SSYIS1_RS06685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SSYIS1_RS06695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SSYIS1_RS06700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SSYIS1_RS06705	COG0772	Belongs to the SEDS family
SSYIS1_RS06715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SSYIS1_RS06720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SSYIS1_RS06725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SSYIS1_RS06730	COG0768	penicillin binding
SSYIS1_RS06735	COG3116	cell division
SSYIS1_RS06740	COG0275	rRNA processing
SSYIS1_RS06745	COG2001	Belongs to the MraZ family
SSYIS1_RS06760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SSYIS1_RS06765	COG0066	3-isopropylmalate dehydratase activity
SSYIS1_RS06770	COG0471	metal ion transport
SSYIS1_RS06775	COG2814	Major facilitator Superfamily
SSYIS1_RS06810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SSYIS1_RS06820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SSYIS1_RS06825	COG0505	Belongs to the CarA family
SSYIS1_RS06835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SSYIS1_RS06840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SSYIS1_RS06845	COG1047	Peptidyl-prolyl cis-trans
SSYIS1_RS06850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SSYIS1_RS06855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SSYIS1_RS06860	COG0196	riboflavin kinase activity
SSYIS1_RS06865	COG0268	Binds directly to 16S ribosomal RNA
SSYIS1_RS06875	COG0484	heat shock protein binding
SSYIS1_RS06880	COG0443	Heat shock 70 kDa protein
SSYIS1_RS06890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SSYIS1_RS06895	COG3022	response to hydroperoxide
SSYIS1_RS06915	COG0745	RESPONSE REGULATOR receiver
SSYIS1_RS06920	COG3045	CreA protein
SSYIS1_RS06940	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
SSYIS1_RS06980	COG0713	ATP synthesis coupled electron transport
SSYIS1_RS06985	COG0839	Belongs to the complex I subunit 6 family
SSYIS1_RS06995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SSYIS1_RS07020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SSYIS1_RS07025	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SSYIS1_RS07040	COG0436	Aminotransferase
SSYIS1_RS07045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SSYIS1_RS07050	COG3092	negative regulation of chromosome organization
SSYIS1_RS07055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SSYIS1_RS07060	COG0857	belongs to the CobB CobQ family
SSYIS1_RS07060	COG0280	phosphate acetyltransferase
SSYIS1_RS07080	COG0625	glutathione transferase activity
SSYIS1_RS07085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SSYIS1_RS07090	COG0163	prenyltransferase activity
SSYIS1_RS07095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SSYIS1_RS07100	COG1286	toxin biosynthetic process
SSYIS1_RS07105	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
SSYIS1_RS07110	COG0285	dihydrofolate synthase activity
SSYIS1_RS07115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SSYIS1_RS07130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SSYIS1_RS07135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SSYIS1_RS07160	COG0582	viral genome integration into host DNA
SSYIS1_RS07195	COG3008	intermembrane lipid transfer
SSYIS1_RS07195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SSYIS1_RS07200	COG2995	paraquat-inducible protein a
SSYIS1_RS07205	COG0488	(ABC) transporter
SSYIS1_RS07210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SSYIS1_RS07210	COG0116	Belongs to the methyltransferase superfamily
SSYIS1_RS07215	COG0633	Ferredoxin
SSYIS1_RS07215	COG3217	Mosc domain protein beta barrel domain protein
SSYIS1_RS07225	COG0167	dihydroorotate dehydrogenase activity
SSYIS1_RS07230	COG0308	aminopeptidase N
SSYIS1_RS07240	COG0017	Asparaginyl-tRNA synthetase
SSYIS1_RS07250	COG1448	Aminotransferase
SSYIS1_RS07255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSYIS1_RS07260	COG3108	Peptidase M15
SSYIS1_RS07265	COG2989	Protein conserved in bacteria
SSYIS1_RS07270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SSYIS1_RS07280	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
SSYIS1_RS07285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SSYIS1_RS07290	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SSYIS1_RS07295	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SSYIS1_RS07300	COG2835	tetraacyldisaccharide 4'-kinase activity
SSYIS1_RS07310	COG2951	lytic endotransglycosylase activity
SSYIS1_RS07320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SSYIS1_RS07335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SSYIS1_RS07355	COG0582	viral genome integration into host DNA
SSYIS1_RS07425	COG1802	Transcriptional regulator
SSYIS1_RS07425	COG4626	Terminase
SSYIS1_RS07485	COG2190	(PTS) system
SSYIS1_RS07490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SSYIS1_RS07495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSYIS1_RS07505	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
SSYIS1_RS07510	COG3115	cell septum assembly
SSYIS1_RS07515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SSYIS1_RS07520	COG1120	ATPase activity
SSYIS1_RS07530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSYIS1_RS07555	COG4208	sulfate ABC transporter
SSYIS1_RS07635	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS07650	COG4372	Transposase
SSYIS1_RS07715	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SSYIS1_RS07755	COG1192	Involved in chromosome partitioning
SSYIS1_RS07795	COG3328	transposase activity
SSYIS1_RS07820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SSYIS1_RS07845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SSYIS1_RS07895	COG4886	Leucine-rich repeat (LRR) protein
SSYIS1_RS07935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SSYIS1_RS07965	COG3328	transposase activity
SSYIS1_RS08000	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
SSYIS1_RS08025	COG3210	domain, Protein
SSYIS1_RS08025	COG3468	outer membrane autotransporter barrel domain protein
SSYIS1_RS08030	COG3328	transposase activity
SSYIS1_RS08040	COG1530	ribonuclease E activity
SSYIS1_RS08045	COG0564	pseudouridine synthase activity
SSYIS1_RS08060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SSYIS1_RS08065	COG0416	fatty acid biosynthetic process
SSYIS1_RS08070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SSYIS1_RS08085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SSYIS1_RS08090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SSYIS1_RS08105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SSYIS1_RS08110	COG0470	DNA polymerase III
SSYIS1_RS08115	COG0084	hydrolase, TatD family'
SSYIS1_RS08120	COG1263	PTS System
SSYIS1_RS08120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSYIS1_RS08125	COG1321	iron dependent repressor
SSYIS1_RS08130	COG0537	adenosine 5'-monophosphoramidase activity
SSYIS1_RS08135	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
SSYIS1_RS08150	COG1252	NADH dehydrogenase
SSYIS1_RS08175	COG1528	Iron-storage protein
SSYIS1_RS08195	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SSYIS1_RS08200	COG3328	transposase activity
SSYIS1_RS08205	COG4565	transcriptional regulatory protein
SSYIS1_RS08210	COG3290	protein histidine kinase activity
SSYIS1_RS08245	COG2197	response regulator
SSYIS1_RS08250	COG0322	excinuclease ABC activity
SSYIS1_RS08335	COG3561	AntA/AntB antirepressor
SSYIS1_RS08365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SSYIS1_RS08370	COG0488	(ABC) transporter
SSYIS1_RS08375	COG0579	oxidoreductase
SSYIS1_RS08390	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS08435	COG2801	Transposase and inactivated derivatives
SSYIS1_RS08450	COG1218	3'(2'),5'-bisphosphate nucleotidase
SSYIS1_RS08470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SSYIS1_RS08480	COG0360	Binds together with S18 to 16S ribosomal RNA
SSYIS1_RS08485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSYIS1_RS08490	COG0557	exoribonuclease II activity
SSYIS1_RS08495	COG1959	2 iron, 2 sulfur cluster binding
SSYIS1_RS08500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SSYIS1_RS08505	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
SSYIS1_RS08510	COG0330	HflC and HflK could
SSYIS1_RS08515	COG0330	HflC and HflK could
SSYIS1_RS08520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SSYIS1_RS08525	COG1923	regulation of RNA biosynthetic process
SSYIS1_RS08530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SSYIS1_RS08535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SSYIS1_RS08545	COG0802	atpase or kinase
SSYIS1_RS08555	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SSYIS1_RS08560	COG1162	GTPase activity
SSYIS1_RS08565	COG0688	phosphatidylethanolamine metabolic process
SSYIS1_RS08570	COG3264	Mechanosensitive ion channel
SSYIS1_RS08570	COG1511	domain protein
SSYIS1_RS08575	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SSYIS1_RS08585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SSYIS1_RS08590	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
SSYIS1_RS08595	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
SSYIS1_RS08605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SSYIS1_RS08645	COG4232	protein-disulfide reductase activity
SSYIS1_RS08655	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SSYIS1_RS08700	COG3328	transposase activity
SSYIS1_RS08705	COG3066	DNA modification
SSYIS1_RS08715	COG0494	nUDIX hydrolase
SSYIS1_RS08720	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
SSYIS1_RS08725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SSYIS1_RS08730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SSYIS1_RS08735	COG2165	general secretion pathway protein
SSYIS1_RS08755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SSYIS1_RS08760	COG1025	Belongs to the peptidase M16 family
SSYIS1_RS08765	COG1074	ATP-dependent DNA helicase activity
SSYIS1_RS08770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SSYIS1_RS08775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SSYIS1_RS08775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SSYIS1_RS08790	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SSYIS1_RS08795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SSYIS1_RS08805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SSYIS1_RS08820	COG2363	Small membrane protein
SSYIS1_RS08825	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
SSYIS1_RS08830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSYIS1_RS08835	COG1611	Belongs to the LOG family
SSYIS1_RS08845	COG3098	single-species biofilm formation
SSYIS1_RS08900	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
SSYIS1_RS08905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SSYIS1_RS08935	COG0023	Translation Initiation Factor
SSYIS1_RS08950	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
SSYIS1_RS08955	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SSYIS1_RS08955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SSYIS1_RS08970	COG4171	peptide transport system, permease
SSYIS1_RS08985	COG2814	Major facilitator Superfamily
SSYIS1_RS09030	COG0531	amino acid
SSYIS1_RS09040	COG1049	propionate catabolic process, 2-methylcitrate cycle
SSYIS1_RS09045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSYIS1_RS09050	COG0508	dehydrogenase complex catalyzes the overall conversion of
SSYIS1_RS09055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SSYIS1_RS09065	COG1113	amino acid transport
SSYIS1_RS09105	COG2252	PERMEase
SSYIS1_RS09110	COG0741	lytic transglycosylase activity
SSYIS1_RS09115	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SSYIS1_RS09125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SSYIS1_RS09130	COG3171	Protein conserved in bacteria
SSYIS1_RS09135	COG2823	Periplasmic or secreted lipoprotein
SSYIS1_RS09140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SSYIS1_RS09145	COG0792	nuclease activity
SSYIS1_RS09150	COG3107	peptidoglycan biosynthetic process
SSYIS1_RS09155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SSYIS1_RS09170	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
SSYIS1_RS09175	COG4575	ribosome binding
SSYIS1_RS09185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SSYIS1_RS09190	COG0586	Pfam SNARE associated Golgi protein
SSYIS1_RS09210	COG0067	glutamate synthase
SSYIS1_RS09210	COG0069	glutamate synthase activity
SSYIS1_RS09210	COG0070	glutamate synthase
SSYIS1_RS09215	COG0493	'glutamate synthase
SSYIS1_RS09220	COG2969	positive regulation of protein catabolic process
SSYIS1_RS09225	COG0625	glutathione transferase activity
SSYIS1_RS09230	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SSYIS1_RS09235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SSYIS1_RS09245	COG3105	Protein conserved in bacteria
SSYIS1_RS09250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SSYIS1_RS09270	COG0586	Pfam SNARE associated Golgi protein
SSYIS1_RS09285	COG0848	biopolymer transport protein
SSYIS1_RS09305	COG3924	membrane
SSYIS1_RS09310	COG4145	pantothenate transmembrane transporter activity
SSYIS1_RS09315	COG2264	protein methyltransferase activity
SSYIS1_RS09340	COG2831	hemolysin activation secretion protein
SSYIS1_RS09345	COG3072	Adenylate cyclase
SSYIS1_RS09360	COG2959	enzyme of heme biosynthesis
SSYIS1_RS09370	COG0859	PFAM glycosyl transferase family 9
SSYIS1_RS09380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SSYIS1_RS09400	COG1448	Aminotransferase
SSYIS1_RS09405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SSYIS1_RS09410	COG0629	single-stranded DNA binding
SSYIS1_RS09430	COG3620	sequence-specific DNA binding
SSYIS1_RS09470	COG1965	Belongs to the frataxin family
SSYIS1_RS09475	COG5567	small periplasmic lipoprotein
SSYIS1_RS09480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SSYIS1_RS09495	COG1011	Hydrolase
SSYIS1_RS09500	COG0210	DNA helicase
SSYIS1_RS09510	COG2962	Rard protein
SSYIS1_RS09520	COG1280	lysine exporter protein (LysE YggA)
SSYIS1_RS09530	COG0561	phosphatase activity
SSYIS1_RS09540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SSYIS1_RS09545	COG0425	Belongs to the sulfur carrier protein TusA family
SSYIS1_RS09555	COG3776	membrane
SSYIS1_RS09560	COG0742	ribosomal rna small subunit methyltransferase
SSYIS1_RS09565	COG0552	protein localization to endoplasmic reticulum
SSYIS1_RS09570	COG2884	Cell division ATP-binding protein ftsE
SSYIS1_RS09575	COG2177	Part of the ABC transporter FtsEX involved in
SSYIS1_RS09585	COG0456	acetyltransferase
SSYIS1_RS09590	COG0586	Pfam SNARE associated Golgi protein
SSYIS1_RS09600	COG2814	Major facilitator Superfamily
SSYIS1_RS09605	COG1187	pseudouridine synthase activity
SSYIS1_RS09610	COG1061	Type III restriction enzyme res subunit
SSYIS1_RS09615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SSYIS1_RS09620	COG3081	Nucleoid-associated protein
SSYIS1_RS09630	COG0247	lactate metabolic process
SSYIS1_RS09630	COG0277	FAD linked oxidase domain protein
SSYIS1_RS09640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SSYIS1_RS09665	COG1663	tetraacyldisaccharide 4'-kinase activity
SSYIS1_RS09680	COG0776	regulation of translation
SSYIS1_RS09685	COG0539	negative regulation of cytoplasmic translation
SSYIS1_RS09690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SSYIS1_RS09695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SSYIS1_RS09700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SSYIS1_RS09715	COG0673	inositol 2-dehydrogenase activity
SSYIS1_RS09720	COG1172	Belongs to the binding-protein-dependent transport system permease family
SSYIS1_RS09745	COG2801	Transposase and inactivated derivatives
SSYIS1_RS09785	COG2062	phosphohistidine phosphatase, SixA
SSYIS1_RS09790	COG2840	Smr protein MutS2
SSYIS1_RS09795	COG2890	protein-(glutamine-N5) methyltransferase activity
SSYIS1_RS09800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SSYIS1_RS09835	COG3852	Histidine kinase
SSYIS1_RS09840	COG0174	glutamine synthetase
SSYIS1_RS09845	COG1217	gtp-binding protein TYPA
SSYIS1_RS09850	COG0463	Glycosyl transferase, family 2
SSYIS1_RS09880	COG3715	PTS system
SSYIS1_RS09885	COG3716	PTS system mannose fructose sorbose family IID component
SSYIS1_RS09890	COG4811	Protein of unknown function (DUF986)
SSYIS1_RS09895	COG1971	Probably functions as a manganese efflux pump
SSYIS1_RS09905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SSYIS1_RS09910	COG0126	phosphoglycerate kinase activity
SSYIS1_RS09915	COG0191	fructose-bisphosphate aldolase activity
SSYIS1_RS09935	COG0583	DNA-binding transcription factor activity
SSYIS1_RS09940	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SSYIS1_RS09945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SSYIS1_RS09950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SSYIS1_RS09960	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SSYIS1_RS09965	COG3079	Belongs to the UPF0149 family
SSYIS1_RS09970	COG0006	proline dipeptidase activity
SSYIS1_RS09975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SSYIS1_RS09980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SSYIS1_RS09990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SSYIS1_RS09990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SSYIS1_RS09995	COG1272	protein, Hemolysin III
SSYIS1_RS10000	COG0354	folic acid binding
SSYIS1_RS10020	COG4974	Belongs to the 'phage' integrase family
SSYIS1_RS10025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SSYIS1_RS10030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SSYIS1_RS10040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SSYIS1_RS10120	COG3085	chromosome segregation
SSYIS1_RS10140	COG3978	acetolactate synthase activity
SSYIS1_RS10150	COG0129	dihydroxy-acid dehydratase activity
SSYIS1_RS10155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SSYIS1_RS10165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SSYIS1_RS10170	COG1295	ribonuclease BN
SSYIS1_RS10180	COG5001	Diguanylate cyclase
SSYIS1_RS10200	COG2732	(Barnase) inhibitor
SSYIS1_RS10205	COG3028	Belongs to the UPF0307 family
SSYIS1_RS10210	COG0312	modulator of DNA gyrase
SSYIS1_RS10290	COG0528	UMP kinase activity
SSYIS1_RS10295	COG0233	cytoplasmic translational termination
SSYIS1_RS10300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SSYIS1_RS10305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SSYIS1_RS10310	COG0575	Belongs to the CDS family
SSYIS1_RS10315	COG0750	zinc metalloprotease
SSYIS1_RS10320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SSYIS1_RS10325	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
SSYIS1_RS10330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SSYIS1_RS10335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SSYIS1_RS10340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SSYIS1_RS10345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SSYIS1_RS10350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SSYIS1_RS10360	COG0825	malonyl-CoA metabolic process
SSYIS1_RS10365	COG0037	tRNA processing
SSYIS1_RS10370	COG4568	rho-dependent transcription termination
SSYIS1_RS10385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SSYIS1_RS10395	COG0442	prolyl-tRNA aminoacylation
SSYIS1_RS10400	COG1720	tRNA m6t6A37 methyltransferase activity
SSYIS1_RS10415	COG2011	ABC-type metal ion transport system permease component
SSYIS1_RS10425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SSYIS1_RS10480	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SSYIS1_RS10500	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SSYIS1_RS10515	COG3170	Tfp pilus assembly protein FimV
SSYIS1_RS10525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SSYIS1_RS10525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SSYIS1_RS10530	COG0347	Belongs to the P(II) protein family
SSYIS1_RS10540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SSYIS1_RS10540	COG1017	nitric oxide dioxygenase activity
SSYIS1_RS10545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SSYIS1_RS10550	COG3683	transport system, periplasmic component
SSYIS1_RS10555	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SSYIS1_RS10565	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SSYIS1_RS10580	COG0822	iron-sulfur transferase activity
SSYIS1_RS10585	COG0316	Belongs to the HesB IscA family
SSYIS1_RS10590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SSYIS1_RS10595	COG0443	Heat shock 70 kDa protein
SSYIS1_RS10600	COG0633	Ferredoxin
SSYIS1_RS10605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SSYIS1_RS10615	COG0105	UTP biosynthetic process
SSYIS1_RS10620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SSYIS1_RS10635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SSYIS1_RS10640	COG0124	histidyl-tRNA synthetase
SSYIS1_RS10645	COG2976	Protein conserved in bacteria
SSYIS1_RS10650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SSYIS1_RS10655	COG1160	GTP binding
SSYIS1_RS10675	COG1570	exodeoxyribonuclease VII activity
SSYIS1_RS10685	COG0517	IMP dehydrogenase activity
SSYIS1_RS10685	COG0516	GMP reductase activity
SSYIS1_RS10690	COG0519	Catalyzes the synthesis of GMP from XMP
SSYIS1_RS10690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SSYIS1_RS10730	COG0795	lipopolysaccharide-transporting ATPase activity
SSYIS1_RS10735	COG0795	lipopolysaccharide-transporting ATPase activity
SSYIS1_RS10740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SSYIS1_RS10745	COG2927	DNA polymerase III (CHI subunit)
SSYIS1_RS10760	COG0745	RESPONSE REGULATOR receiver
SSYIS1_RS10790	COG0573	inorganic phosphate transmembrane transporter activity
SSYIS1_RS10805	COG2860	membrane
SSYIS1_RS10815	COG1758	RNA polymerase activity
SSYIS1_RS10820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SSYIS1_RS10825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSYIS1_RS10830	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SSYIS1_RS10850	COG1490	D-aminoacyl-tRNA deacylase activity
SSYIS1_RS10875	COG3422	double-strand break repair
SSYIS1_RS10910	COG2239	Acts as a magnesium transporter
SSYIS1_RS10925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SSYIS1_RS10930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SSYIS1_RS10935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SSYIS1_RS10955	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS10970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSYIS1_RS10970	COG2213	PTS system mannitol-specific
SSYIS1_RS10975	COG0246	Mannitol dehydrogenase
SSYIS1_RS10980	COG3722	fumarate hydratase activity
SSYIS1_RS11010	COG1322	Protein conserved in bacteria
SSYIS1_RS11015	COG2226	methyltransferase
SSYIS1_RS11020	COG3165	ubiquinone biosynthetic process from chorismate
SSYIS1_RS11025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SSYIS1_RS11030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SSYIS1_RS11040	COG0805	protein transport
SSYIS1_RS11095	COG2244	polysaccharide biosynthetic process
SSYIS1_RS11100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SSYIS1_RS11105	COG0456	acetyltransferase
SSYIS1_RS11110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SSYIS1_RS11115	COG1088	dTDP-glucose 4,6-dehydratase activity
SSYIS1_RS11120	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SSYIS1_RS11125	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SSYIS1_RS11160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SSYIS1_RS11165	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SSYIS1_RS11170	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SSYIS1_RS11175	COG1609	Transcriptional regulator
SSYIS1_RS11180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SSYIS1_RS11185	COG0254	rRNA binding
SSYIS1_RS11190	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
SSYIS1_RS11200	COG0460	homoserine dehydrogenase
SSYIS1_RS11200	COG0527	aspartate kinase activity
SSYIS1_RS11210	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SSYIS1_RS11225	COG1438	arginine binding
SSYIS1_RS11230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SSYIS1_RS11235	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SSYIS1_RS11240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SSYIS1_RS11255	COG0488	(ABC) transporter
SSYIS1_RS11260	COG0488	(ABC) transporter
SSYIS1_RS11270	COG2267	carboxylic ester hydrolase activity
SSYIS1_RS11300	COG2003	Belongs to the UPF0758 family
SSYIS1_RS11330	COG1301	dicarboxylic acid transport
SSYIS1_RS11340	COG3162	membrane
SSYIS1_RS11380	COG0138	bifunctional purine biosynthesis protein purh
SSYIS1_RS11385	COG0151	Belongs to the GarS family
SSYIS1_RS11405	COG1515	deoxyribonuclease V activity
SSYIS1_RS11410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SSYIS1_RS11420	COG0352	thiamine-phosphate diphosphorylase activity
SSYIS1_RS11425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SSYIS1_RS11430	COG2104	thiamine diphosphate biosynthetic process
SSYIS1_RS11435	COG2022	thiamine diphosphate biosynthetic process
SSYIS1_RS11470	COG1561	YicC-like family, N-terminal region
SSYIS1_RS11475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SSYIS1_RS11480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SSYIS1_RS11485	COG1309	transcriptional regulator
SSYIS1_RS11490	COG0756	dUTP diphosphatase activity
SSYIS1_RS11495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SSYIS1_RS11500	COG2003	Belongs to the UPF0758 family
SSYIS1_RS11505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SSYIS1_RS11510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SSYIS1_RS11520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SSYIS1_RS11530	COG1519	Transferase
SSYIS1_RS11540	COG0438	transferase activity, transferring glycosyl groups
SSYIS1_RS11545	COG0438	transferase activity, transferring glycosyl groups
SSYIS1_RS11550	COG0859	PFAM glycosyl transferase family 9
SSYIS1_RS11565	COG0859	PFAM glycosyl transferase family 9
SSYIS1_RS11595	COG2853	Lipoprotein
SSYIS1_RS11615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SSYIS1_RS11630	COG3101	peptidyl-lysine hydroxylation
SSYIS1_RS11670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SSYIS1_RS11680	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSYIS1_RS11685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSYIS1_RS11735	COG0347	Belongs to the P(II) protein family
SSYIS1_RS11740	COG1132	(ABC) transporter
SSYIS1_RS11745	COG1132	(ABC) transporter
SSYIS1_RS11765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SSYIS1_RS11770	COG1555	photosystem II stabilization
SSYIS1_RS11775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SSYIS1_RS11785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SSYIS1_RS11790	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SSYIS1_RS11795	COG0740	serine-type endopeptidase activity
SSYIS1_RS11800	COG0544	peptidyl-prolyl cis-trans isomerase activity
SSYIS1_RS11805	COG0271	Belongs to the BolA IbaG family
SSYIS1_RS11810	COG3056	Lipoprotein
SSYIS1_RS11815	COG2223	nitrite transmembrane transporter activity
SSYIS1_RS11820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SSYIS1_RS11825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SSYIS1_RS11830	COG1845	cytochrome c oxidase, subunit III
SSYIS1_RS11835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SSYIS1_RS11840	COG0109	protoheme IX farnesyltransferase activity
SSYIS1_RS11845	COG2814	Major facilitator Superfamily
SSYIS1_RS11850	COG1666	GTP binding
SSYIS1_RS11860	COG0693	protein deglycase activity
SSYIS1_RS11865	COG0301	tRNA thio-modification
SSYIS1_RS11865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SSYIS1_RS11875	COG0142	geranyltranstransferase activity
SSYIS1_RS11880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SSYIS1_RS11885	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SSYIS1_RS11890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SSYIS1_RS11895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SSYIS1_RS11900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SSYIS1_RS11905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SSYIS1_RS11905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SSYIS1_RS11910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SSYIS1_RS11915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SSYIS1_RS11920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SSYIS1_RS11925	COG1862	Preprotein translocase
SSYIS1_RS11930	COG0343	queuine tRNA-ribosyltransferase activity
SSYIS1_RS11950	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS11975	COG5645	(Lipo)protein
SSYIS1_RS12000	COG0752	glycyl-tRNA synthetase alpha subunit
SSYIS1_RS12005	COG0751	glycine-tRNA ligase activity
SSYIS1_RS12025	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS12050	COG1470	cell adhesion involved in biofilm formation
SSYIS1_RS12050	COG1388	LysM domain
SSYIS1_RS12055	COG1470	cell adhesion involved in biofilm formation
SSYIS1_RS12055	COG1388	LysM domain
SSYIS1_RS12060	COG1671	Belongs to the UPF0178 family
SSYIS1_RS12065	COG0408	coproporphyrinogen oxidase activity
SSYIS1_RS12070	COG0456	acetyltransferase
SSYIS1_RS12095	COG4372	Transposase
SSYIS1_RS12100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SSYIS1_RS12105	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
SSYIS1_RS12110	COG0450	alkyl hydroperoxide reductase
SSYIS1_RS12140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SSYIS1_RS12150	COG1278	Cold shock
SSYIS1_RS12160	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS12170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SSYIS1_RS12180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SSYIS1_RS12185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SSYIS1_RS12195	COG4988	ABC transporter
SSYIS1_RS12205	COG0492	ferredoxin-NADP+ reductase activity
SSYIS1_RS12220	COG3107	peptidoglycan biosynthetic process
SSYIS1_RS12220	COG1674	ftsk spoiiie
SSYIS1_RS12225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SSYIS1_RS12235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SSYIS1_RS12255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SSYIS1_RS12265	COG0589	response to stress
SSYIS1_RS12270	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SSYIS1_RS12275	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SSYIS1_RS12305	COG3188	usher protein
SSYIS1_RS12310	COG3121	Chaperone
SSYIS1_RS12320	COG2200	EAL domain
SSYIS1_RS12335	COG0582	viral genome integration into host DNA
SSYIS1_RS12340	COG0799	negative regulation of ribosome biogenesis
SSYIS1_RS12345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SSYIS1_RS12350	COG0768	penicillin binding
SSYIS1_RS12355	COG0772	Belongs to the SEDS family
SSYIS1_RS12375	COG1686	Belongs to the peptidase S11 family
SSYIS1_RS12385	COG2921	Belongs to the UPF0250 family
SSYIS1_RS12390	COG0321	lipoyl(octanoyl) transferase activity
SSYIS1_RS12415	COG3299	homolog of phage Mu protein gp47
SSYIS1_RS12460	COG4386	tail sheath protein
SSYIS1_RS12565	COG3082	Protein of unknown function (DUF1414)
SSYIS1_RS12570	COG3083	sulfuric ester hydrolase activity
SSYIS1_RS12625	COG3617	BRO family, N-terminal domain
SSYIS1_RS12645	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SSYIS1_RS12650	COG3118	belongs to the thioredoxin family
SSYIS1_RS12655	COG0513	Belongs to the DEAD box helicase family
SSYIS1_RS12665	COG0210	DNA helicase
SSYIS1_RS12670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SSYIS1_RS12720	COG0205	6-phosphofructokinase activity
SSYIS1_RS12725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SSYIS1_RS12730	COG0149	triose-phosphate isomerase activity
SSYIS1_RS12755	COG2827	Endonuclease containing a URI domain
SSYIS1_RS12760	COG3153	acetyltransferase
SSYIS1_RS12785	COG0513	Belongs to the DEAD box helicase family
SSYIS1_RS12800	COG1185	polyribonucleotide nucleotidyltransferase activity
SSYIS1_RS12805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SSYIS1_RS12810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SSYIS1_RS12815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SSYIS1_RS12820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SSYIS1_RS12825	COG0195	Participates in both transcription termination and antitermination
SSYIS1_RS12830	COG0779	Required for maturation of 30S ribosomal subunits
SSYIS1_RS12845	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SSYIS1_RS12850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SSYIS1_RS12855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SSYIS1_RS12865	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SSYIS1_RS12870	COG1534	Rna-binding protein
SSYIS1_RS12880	COG2027	D-alanyl-D-alanine carboxypeptidase
SSYIS1_RS12885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SSYIS1_RS12890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SSYIS1_RS12895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SSYIS1_RS12900	COG0142	geranyltranstransferase activity
SSYIS1_RS12925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SSYIS1_RS12930	COG1466	dna polymerase III delta subunit
SSYIS1_RS12935	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
SSYIS1_RS12940	COG0495	leucyl-tRNA aminoacylation
SSYIS1_RS12945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SSYIS1_RS12950	COG4535	Mg2 and Co2 transporter CorC
SSYIS1_RS12955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SSYIS1_RS12960	COG1702	phosphate starvation-inducible protein PhoH
SSYIS1_RS12965	COG2824	Alkylphosphonate utilization operon protein PhnA
SSYIS1_RS12975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SSYIS1_RS13005	COG0367	asparagine synthase
SSYIS1_RS13010	COG1940	carbohydrate kinase activity
SSYIS1_RS13010	COG1846	Transcriptional regulator
SSYIS1_RS13015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SSYIS1_RS13020	COG0363	glucosamine-6-phosphate deaminase activity
SSYIS1_RS13025	COG1263	PTS System
SSYIS1_RS13025	COG2190	(PTS) system
SSYIS1_RS13025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSYIS1_RS13030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SSYIS1_RS13055	COG3133	Outer membrane lipoprotein
SSYIS1_RS13060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SSYIS1_RS13070	COG0259	pyridoxamine-phosphate oxidase activity
SSYIS1_RS13075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SSYIS1_RS13090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SSYIS1_RS13100	COG0527	aspartate kinase activity
SSYIS1_RS13105	COG0166	Belongs to the GPI family
SSYIS1_RS13110	COG3161	chorismate lyase activity
SSYIS1_RS13115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SSYIS1_RS13120	COG2937	Belongs to the GPAT DAPAT family
SSYIS1_RS13125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SSYIS1_RS13130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SSYIS1_RS13140	COG0735	belongs to the Fur family
SSYIS1_RS13200	COG0556	nucleotide-excision repair
SSYIS1_RS13210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SSYIS1_RS13220	COG0315	cyclic pyranopterin monophosphate synthase activity
SSYIS1_RS13225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SSYIS1_RS13230	COG0314	molybdopterin synthase activity
SSYIS1_RS13235	COG0670	Belongs to the BI1 family
SSYIS1_RS13240	COG0513	Belongs to the DEAD box helicase family
SSYIS1_RS13255	COG3433	isochorismatase activity
SSYIS1_RS13255	COG1535	isochorismatase
SSYIS1_RS13320	COG5499	transcription regulator containing HTH domain
SSYIS1_RS13325	COG4680	protein conserved in bacteria
SSYIS1_RS13390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SSYIS1_RS13395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SSYIS1_RS13405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SSYIS1_RS13415	COG2918	glutathione biosynthetic process
SSYIS1_RS13430	COG4137	Cytochrome C assembly protein
SSYIS1_RS13435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SSYIS1_RS13440	COG0228	four-way junction DNA binding
SSYIS1_RS13445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SSYIS1_RS13470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SSYIS1_RS13475	COG1605	Chorismate mutase
SSYIS1_RS13475	COG0287	Prephenate dehydrogenase
SSYIS1_RS13480	COG0077	Prephenate dehydratase
SSYIS1_RS13480	COG1605	Chorismate mutase
SSYIS1_RS13495	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SSYIS1_RS13505	COG0564	pseudouridine synthase activity
SSYIS1_RS13515	COG0542	response to heat
SSYIS1_RS13555	COG3162	membrane
SSYIS1_RS13565	COG1301	dicarboxylic acid transport
SSYIS1_RS13580	COG3112	Uncharacterised protein family (UPF0231)
SSYIS1_RS13605	COG0288	reversible hydration of carbon dioxide
SSYIS1_RS13610	COG1131	(ABC) transporter
SSYIS1_RS13615	COG0842	Transport permease protein
SSYIS1_RS13630	COG3436	PFAM IS66 Orf2 family protein
SSYIS1_RS13680	COG0471	metal ion transport
SSYIS1_RS13700	COG0655	NAD(P)H dehydrogenase (quinone) activity
SSYIS1_RS13715	COG2081	HI0933 family
SSYIS1_RS13720	COG0306	phosphate transporter
SSYIS1_RS13765	COG1082	Xylose isomerase domain protein TIM barrel
SSYIS1_RS13775	COG0589	response to stress
SSYIS1_RS13790	COG0742	ribosomal rna small subunit methyltransferase
SSYIS1_RS13800	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SSYIS1_RS13805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSYIS1_RS13865	COG0477	Major facilitator Superfamily
SSYIS1_RS13895	COG0716	FMN binding
SSYIS1_RS13925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SSYIS1_RS13945	COG5464	transposase or invertase
SSYIS1_RS14010	COG3504	Conjugal transfer protein
SSYIS1_RS14060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SSYIS1_RS14070	COG0071	Belongs to the small heat shock protein (HSP20) family
SSYIS1_RS14100	COG0741	lytic transglycosylase activity
SSYIS1_RS14180	COG5464	transposase or invertase
SSYIS1_RS14315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SSYIS1_RS14320	COG0071	Belongs to the small heat shock protein (HSP20) family