locus-tag	class	description
C8I07_RS00050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C8I07_RS00120	COG1196	nuclear chromosome segregation
C8I07_RS00130	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C8I07_RS00150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C8I07_RS00205	COG1573	uracil-dna glycosylase
C8I07_RS00210	COG3835	regulator
C8I07_RS00230	COG1929	Belongs to the glycerate kinase type-1 family
C8I07_RS00235	COG0076	glutamate decarboxylase activity
C8I07_RS00305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C8I07_RS00335	COG3104	oligopeptide transport
C8I07_RS00350	COG0318	PFAM AMP-dependent synthetase and ligase
C8I07_RS00355	COG0596	Alpha beta hydrolase
C8I07_RS00360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8I07_RS00385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8I07_RS00425	COG3547	Transposase (IS116 IS110 IS902 family)
C8I07_RS00445	COG0573	inorganic phosphate transmembrane transporter activity
C8I07_RS00505	COG0427	acetyl-CoA hydrolase
C8I07_RS00510	COG0681	Belongs to the peptidase S26 family
C8I07_RS00520	COG1131	(ABC) transporter
C8I07_RS00550	COG4249	Peptidase C14 caspase catalytic subunit p20
C8I07_RS00550	COG2319	Wd-40 repeat
C8I07_RS00565	COG4251	negative regulation of phosphorylation
C8I07_RS00565	COG3706	GGDEF domain
C8I07_RS00565	COG5001	Diguanylate cyclase
C8I07_RS00565	COG2203	Gaf domain
C8I07_RS00580	COG3040	lipid binding
C8I07_RS00585	COG0488	(ABC) transporter
C8I07_RS00590	COG2217	Heavy metal translocating P-type atpase
C8I07_RS00595	COG0789	Transcriptional regulator
C8I07_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS00620	COG1024	Enoyl-CoA hydratase
C8I07_RS00625	COG1024	Enoyl-CoA hydratase
C8I07_RS00630	COG1960	acyl-CoA dehydrogenase activity
C8I07_RS00660	COG3047	cAMP biosynthetic process
C8I07_RS00675	COG0625	glutathione transferase activity
C8I07_RS00700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C8I07_RS00705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C8I07_RS00710	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C8I07_RS00710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C8I07_RS00735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C8I07_RS00740	COG1940	carbohydrate kinase activity
C8I07_RS00750	COG1091	dTDP-4-dehydrorhamnose reductase activity
C8I07_RS00760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C8I07_RS00770	COG1278	Cold shock
C8I07_RS00780	COG3706	GGDEF domain
C8I07_RS00785	COG0037	tRNA processing
C8I07_RS00790	COG0587	DNA-directed DNA polymerase activity
C8I07_RS00805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C8I07_RS00815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C8I07_RS00820	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C8I07_RS00830	COG0750	zinc metalloprotease
C8I07_RS00840	COG0575	Belongs to the CDS family
C8I07_RS00845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C8I07_RS00870	COG0024	Methionine aminopeptidase
C8I07_RS00875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C8I07_RS00890	COG0788	formyltetrahydrofolate deformylase activity
C8I07_RS00895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C8I07_RS00895	COG1263	PTS System
C8I07_RS00900	COG0716	FMN binding
C8I07_RS00910	COG0564	pseudouridine synthase activity
C8I07_RS00915	COG3098	single-species biofilm formation
C8I07_RS00960	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C8I07_RS00975	COG0583	DNA-binding transcription factor activity
C8I07_RS00980	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C8I07_RS01015	COG2070	2-Nitropropane dioxygenase
C8I07_RS01015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C8I07_RS01030	COG1803	Methylglyoxal synthase
C8I07_RS01030	COG1597	lipid kinase activity
C8I07_RS01065	COG0726	polysaccharide deacetylase
C8I07_RS01080	COG0662	Cupin 2, conserved barrel domain protein
C8I07_RS01080	COG2207	Transcriptional regulator
C8I07_RS01085	COG0738	Major facilitator superfamily
C8I07_RS01090	COG1940	carbohydrate kinase activity
C8I07_RS01105	COG0179	Fumarylacetoacetate (FAA) hydrolase
C8I07_RS01110	COG0840	transmembrane signaling receptor activity
C8I07_RS01120	COG1846	Transcriptional regulator
C8I07_RS01125	COG2807	transmembrane transport
C8I07_RS01130	COG2824	Alkylphosphonate utilization operon protein PhnA
C8I07_RS01135	COG1629	transport
C8I07_RS01150	COG0625	glutathione transferase activity
C8I07_RS01155	COG0625	glutathione transferase activity
C8I07_RS01180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8I07_RS01185	COG2976	Protein conserved in bacteria
C8I07_RS01200	COG1426	Protein conserved in bacteria
C8I07_RS01215	COG1253	flavin adenine dinucleotide binding
C8I07_RS01225	COG0583	DNA-binding transcription factor activity
C8I07_RS01230	COG2259	Doxx family
C8I07_RS01235	COG1741	Belongs to the pirin family
C8I07_RS01255	COG3530	Putative quorum-sensing-regulated virulence factor
C8I07_RS01280	COG2203	Gaf domain
C8I07_RS01280	COG5001	Diguanylate cyclase
C8I07_RS01280	COG3706	GGDEF domain
C8I07_RS01280	COG4251	negative regulation of phosphorylation
C8I07_RS01285	COG3228	Belongs to the MtfA family
C8I07_RS01300	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C8I07_RS01315	COG0668	transmembrane transport
C8I07_RS01320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C8I07_RS01325	COG2860	membrane
C8I07_RS01340	COG0023	Translation Initiation Factor
C8I07_RS01350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C8I07_RS01355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C8I07_RS01375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C8I07_RS01380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C8I07_RS01385	COG0762	integral membrane protein
C8I07_RS01400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C8I07_RS01405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C8I07_RS01420	COG1360	Flagellar Motor Protein
C8I07_RS01425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C8I07_RS01430	COG1722	exodeoxyribonuclease VII activity
C8I07_RS01435	COG0142	geranyltranstransferase activity
C8I07_RS01445	COG0583	DNA-binding transcription factor activity
C8I07_RS01460	COG3171	Protein conserved in bacteria
C8I07_RS01470	COG1194	a g-specific adenine glycosylase
C8I07_RS01485	COG3038	cytochrome b561
C8I07_RS01545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C8I07_RS01560	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C8I07_RS01570	COG0415	Belongs to the DNA photolyase family
C8I07_RS01590	COG2217	Heavy metal translocating P-type atpase
C8I07_RS01600	COG1305	Transglutaminase-like
C8I07_RS01620	COG0814	amino acid
C8I07_RS01625	COG0251	oxidation-reduction process
C8I07_RS01635	COG2964	Protein conserved in bacteria
C8I07_RS01650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C8I07_RS01665	COG2311	Membrane
C8I07_RS01680	COG2031	fatty acid transporter
C8I07_RS01685	COG0545	Peptidyl-prolyl cis-trans isomerase
C8I07_RS01695	COG1940	carbohydrate kinase activity
C8I07_RS01705	COG3437	response regulator, receiver
C8I07_RS01710	COG0840	transmembrane signaling receptor activity
C8I07_RS01715	COG0513	Belongs to the DEAD box helicase family
C8I07_RS01720	COG0531	amino acid
C8I07_RS01755	COG2414	aldehyde ferredoxin oxidoreductase
C8I07_RS01770	COG2268	Band 7 protein
C8I07_RS01785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C8I07_RS01810	COG0795	lipopolysaccharide-transporting ATPase activity
C8I07_RS01815	COG0795	lipopolysaccharide-transporting ATPase activity
C8I07_RS01820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C8I07_RS01825	COG2927	DNA polymerase III (CHI subunit)
C8I07_RS01830	COG0525	valine-tRNA ligase activity
C8I07_RS01845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C8I07_RS01850	COG1605	Chorismate mutase
C8I07_RS01850	COG0077	Prephenate dehydratase
C8I07_RS01865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8I07_RS01885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C8I07_RS01890	COG1605	Chorismate mutase
C8I07_RS01890	COG0077	Prephenate dehydratase
C8I07_RS01905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8I07_RS01920	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C8I07_RS01955	COG3026	antisigma factor binding
C8I07_RS01965	COG1595	DNA-templated transcription, initiation
C8I07_RS01970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C8I07_RS01980	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C8I07_RS01985	COG0583	DNA-binding transcription factor activity
C8I07_RS02010	COG0730	response to heat
C8I07_RS02035	COG0583	DNA-binding transcription factor activity
C8I07_RS02040	COG2198	Histidine kinase
C8I07_RS02040	COG5002	protein histidine kinase activity
C8I07_RS02040	COG0784	Response regulator, receiver
C8I07_RS02045	COG1242	4 iron, 4 sulfur cluster binding
C8I07_RS02050	COG0067	glutamate synthase
C8I07_RS02050	COG0069	glutamate synthase activity
C8I07_RS02050	COG0070	glutamate synthase
C8I07_RS02055	COG0493	'glutamate synthase
C8I07_RS02090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C8I07_RS02095	COG4942	peptidase
C8I07_RS02105	COG0745	RESPONSE REGULATOR receiver
C8I07_RS02165	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C8I07_RS02170	COG0527	aspartate kinase activity
C8I07_RS02180	COG2137	regulation of response to DNA damage stimulus
C8I07_RS02195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C8I07_RS02200	COG4942	peptidase
C8I07_RS02200	COG1388	LysM domain
C8I07_RS02215	COG0585	pseudouridine synthase activity
C8I07_RS02225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C8I07_RS02230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C8I07_RS02245	COG3956	TIGRFAM MazG family protein
C8I07_RS02255	COG0154	amidase activity
C8I07_RS02270	COG2865	translation initiation factor activity
C8I07_RS02285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C8I07_RS02310	COG0583	DNA-binding transcription factor activity
C8I07_RS02320	COG0497	DNA recombination
C8I07_RS02325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C8I07_RS02330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C8I07_RS02355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C8I07_RS02355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C8I07_RS02370	COG0488	(ABC) transporter
C8I07_RS02375	COG0583	DNA-binding transcription factor activity
C8I07_RS02405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS02410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8I07_RS02415	COG2814	Major facilitator Superfamily
C8I07_RS02425	COG0697	spore germination
C8I07_RS02465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS02470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8I07_RS02475	COG2814	Major facilitator Superfamily
C8I07_RS02485	COG0697	spore germination
C8I07_RS02530	COG1252	NADH dehydrogenase
C8I07_RS02585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C8I07_RS02590	COG1047	Peptidyl-prolyl cis-trans
C8I07_RS02605	COG0196	riboflavin kinase activity
C8I07_RS02610	COG0728	peptidoglycan biosynthetic process
C8I07_RS02620	COG0640	Transcriptional regulator
C8I07_RS02635	COG1115	amino acid carrier protein
C8I07_RS02640	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C8I07_RS02680	COG2304	oxidoreductase activity
C8I07_RS02685	COG0659	secondary active sulfate transmembrane transporter activity
C8I07_RS02690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C8I07_RS02695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C8I07_RS02700	COG3706	GGDEF domain
C8I07_RS02715	COG2918	glutathione biosynthetic process
C8I07_RS02725	COG1238	metal cluster binding
C8I07_RS02730	COG1301	dicarboxylic acid transport
C8I07_RS02735	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C8I07_RS02740	COG5016	pyruvate
C8I07_RS02740	COG0511	ligase activity, forming carbon-carbon bonds
C8I07_RS02745	COG3630	sodium ion export across plasma membrane
C8I07_RS02770	COG1183	phosphatidylcholine synthase activity
C8I07_RS02780	COG0542	response to heat
C8I07_RS02790	COG0564	pseudouridine synthase activity
C8I07_RS02795	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8I07_RS02820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8I07_RS02820	COG1017	nitric oxide dioxygenase activity
C8I07_RS02860	COG1584	GPR1 FUN34 yaaH family protein
C8I07_RS02880	COG0745	RESPONSE REGULATOR receiver
C8I07_RS02890	COG3313	Fe-S protein
C8I07_RS02915	COG4208	sulfate ABC transporter
C8I07_RS02920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C8I07_RS02930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C8I07_RS02945	COG0564	pseudouridine synthase activity
C8I07_RS02965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C8I07_RS02975	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C8I07_RS02980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C8I07_RS02990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C8I07_RS03000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C8I07_RS03005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C8I07_RS03040	COG3610	response to peptide
C8I07_RS03045	COG2966	Psort location CytoplasmicMembrane, score
C8I07_RS03065	COG0142	geranyltranstransferase activity
C8I07_RS03070	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C8I07_RS03105	COG3604	Transcriptional regulator
C8I07_RS03110	COG0348	domain, Protein
C8I07_RS03115	COG0318	PFAM AMP-dependent synthetase and ligase
C8I07_RS03120	COG1132	(ABC) transporter
C8I07_RS03125	COG0748	coenzyme F420 binding
C8I07_RS03130	COG3721	Heme iron utilization protein
C8I07_RS03145	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C8I07_RS03150	COG0811	peptide transport
C8I07_RS03155	COG0848	biopolymer transport protein
C8I07_RS03165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8I07_RS03170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C8I07_RS03215	COG1309	transcriptional regulator
C8I07_RS03235	COG5002	protein histidine kinase activity
C8I07_RS03245	COG1136	(ABC) transporter
C8I07_RS03245	COG0577	efflux transmembrane transporter activity
C8I07_RS03255	COG1136	(ABC) transporter
C8I07_RS03325	COG1012	belongs to the aldehyde dehydrogenase family
C8I07_RS03330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C8I07_RS03345	COG1492	cobalamin metabolic process
C8I07_RS03365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8I07_RS03370	COG1120	ATPase activity
C8I07_RS03380	COG0646	methionine synthase
C8I07_RS03380	COG1410	methionine synthase
C8I07_RS03410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C8I07_RS03415	COG2080	2 iron, 2 sulfur cluster binding
C8I07_RS03430	COG0583	DNA-binding transcription factor activity
C8I07_RS03440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C8I07_RS03460	COG0387	Pfam Sodium calcium exchanger
C8I07_RS03470	COG1686	Belongs to the peptidase S11 family
C8I07_RS03475	COG3293	Transposase
C8I07_RS03485	COG1346	cytolysis
C8I07_RS03495	COG0583	DNA-binding transcription factor activity
C8I07_RS03505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8I07_RS03510	COG0765	amino acid transport
C8I07_RS03515	COG1126	abc transporter atp-binding protein
C8I07_RS03545	COG0484	heat shock protein binding
C8I07_RS03550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C8I07_RS03560	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C8I07_RS03590	COG3293	Transposase
C8I07_RS03600	COG5002	protein histidine kinase activity
C8I07_RS03610	COG0471	metal ion transport
C8I07_RS03610	COG3273	potassium ion transport
C8I07_RS03615	COG2895	sulfate adenylyltransferase (ATP) activity
C8I07_RS03625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C8I07_RS03625	COG1648	precorrin-2 dehydrogenase activity
C8I07_RS03645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C8I07_RS03655	COG0175	sulfate reduction
C8I07_RS03665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C8I07_RS03670	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C8I07_RS03675	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C8I07_RS03705	COG1560	Kdo2-lipid A biosynthetic process
C8I07_RS03720	COG1376	ErfK ybiS ycfS ynhG family protein
C8I07_RS03735	COG0612	Peptidase, M16
C8I07_RS03740	COG4565	transcriptional regulatory protein
C8I07_RS03745	COG3290	protein histidine kinase activity
C8I07_RS03775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C8I07_RS03795	COG3447	MASE1 domain protein
C8I07_RS03795	COG5001	Diguanylate cyclase
C8I07_RS03795	COG5002	protein histidine kinase activity
C8I07_RS03800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C8I07_RS03815	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C8I07_RS03820	COG3789	protein conserved in bacteria
C8I07_RS03840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C8I07_RS03845	COG3025	triphosphatase activity
C8I07_RS03850	COG1392	Phosphate transport regulator
C8I07_RS03855	COG0306	phosphate transporter
C8I07_RS03860	COG4991	sh3 domain protein
C8I07_RS03900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C8I07_RS03905	COG4988	ABC transporter
C8I07_RS03915	COG0513	Belongs to the DEAD box helicase family
C8I07_RS03925	COG0513	Belongs to the DEAD box helicase family
C8I07_RS03930	COG1741	Belongs to the pirin family
C8I07_RS03955	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C8I07_RS03960	COG0488	(ABC) transporter
C8I07_RS03975	COG1733	regulation of RNA biosynthetic process
C8I07_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS03990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C8I07_RS04000	COG0429	hydrolase of the alpha beta-hydrolase fold
C8I07_RS04010	COG3954	Phosphoribulokinase
C8I07_RS04035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C8I07_RS04045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C8I07_RS04085	COG3647	Membrane
C8I07_RS04090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C8I07_RS04105	COG2205	protein histidine kinase activity
C8I07_RS04105	COG5002	protein histidine kinase activity
C8I07_RS04105	COG0784	Response regulator, receiver
C8I07_RS04110	COG1115	amino acid carrier protein
C8I07_RS04115	COG1136	(ABC) transporter
C8I07_RS04120	COG0577	efflux transmembrane transporter activity
C8I07_RS04145	COG2010	Cytochrome c
C8I07_RS04145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C8I07_RS04150	COG3062	negative regulation of establishment of protein localization
C8I07_RS04155	COG0243	molybdopterin cofactor binding
C8I07_RS04160	COG3043	anaerobic respiration
C8I07_RS04205	COG0439	Biotin carboxylase
C8I07_RS04210	COG0583	DNA-binding transcription factor activity
C8I07_RS04225	COG3091	SprT-like family
C8I07_RS04235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C8I07_RS04240	COG0189	ligase activity
C8I07_RS04245	COG1785	Belongs to the alkaline phosphatase family
C8I07_RS04275	COG1538	Outer membrane efflux protein
C8I07_RS04280	COG0577	efflux transmembrane transporter activity
C8I07_RS04280	COG1136	(ABC) transporter
C8I07_RS04285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS04295	COG3585	molybdate ion transport
C8I07_RS04295	COG2005	Transcriptional regulator
C8I07_RS04300	COG0725	ABC transporter, periplasmic molybdate-binding protein
C8I07_RS04305	COG4149	molybdate abc transporter
C8I07_RS04335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8I07_RS04335	COG4191	Histidine kinase
C8I07_RS04340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C8I07_RS04370	COG3150	esterase
C8I07_RS04375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C8I07_RS04385	COG0494	nUDIX hydrolase
C8I07_RS04390	COG1538	Outer membrane efflux protein
C8I07_RS04410	COG1024	Enoyl-CoA hydratase
C8I07_RS04430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C8I07_RS04445	COG4774	siderophore transport
C8I07_RS04465	COG3591	Belongs to the peptidase S1B family
C8I07_RS04465	COG4990	cell redox homeostasis
C8I07_RS04475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C8I07_RS04495	COG0477	Major facilitator Superfamily
C8I07_RS04500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C8I07_RS04505	COG0557	exoribonuclease II activity
C8I07_RS04510	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C8I07_RS04515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C8I07_RS04520	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C8I07_RS04525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C8I07_RS04535	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C8I07_RS04540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C8I07_RS04545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C8I07_RS04555	COG5007	Belongs to the BolA IbaG family
C8I07_RS04565	COG2854	intermembrane phospholipid transfer
C8I07_RS04570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C8I07_RS04575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C8I07_RS04580	COG1127	ABC transporter
C8I07_RS04590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C8I07_RS04605	COG1137	ATPase activity
C8I07_RS04610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C8I07_RS04620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C8I07_RS04630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C8I07_RS04635	COG2239	Acts as a magnesium transporter
C8I07_RS04645	COG2885	chlorophyll binding
C8I07_RS04680	COG5001	Diguanylate cyclase
C8I07_RS04680	COG3300	MHYT domain
C8I07_RS04695	COG1280	lysine exporter protein (LysE YggA)
C8I07_RS04710	COG1785	Belongs to the alkaline phosphatase family
C8I07_RS04725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8I07_RS04760	COG1119	ATPase activity
C8I07_RS04770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C8I07_RS04835	COG0534	Mate efflux family protein
C8I07_RS04840	COG0583	DNA-binding transcription factor activity
C8I07_RS04850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8I07_RS04865	COG1324	tolerance protein
C8I07_RS04870	COG4232	protein-disulfide reductase activity
C8I07_RS04880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C8I07_RS04885	COG2017	converts alpha-aldose to the beta-anomer
C8I07_RS04900	COG3321	synthase
C8I07_RS04900	COG0604	alcohol dehydrogenase
C8I07_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS04905	COG3291	Pkd domain containing protein
C8I07_RS04915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8I07_RS04920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS04930	COG0741	lytic transglycosylase activity
C8I07_RS04930	COG1388	LysM domain
C8I07_RS04950	COG0612	Peptidase, M16
C8I07_RS04960	COG0252	asparaginase activity
C8I07_RS04965	COG1027	Aspartate ammonia-lyase
C8I07_RS04970	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C8I07_RS04980	COG1053	succinate dehydrogenase
C8I07_RS04985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C8I07_RS04990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C8I07_RS04995	COG0629	single-stranded DNA binding
C8I07_RS05000	COG2814	Major facilitator Superfamily
C8I07_RS05005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C8I07_RS05010	COG2234	aminopeptidase activity
C8I07_RS05015	COG0513	Belongs to the DEAD box helicase family
C8I07_RS05035	COG0546	phosphoglycolate phosphatase activity
C8I07_RS05070	COG3258	Cytochrome c
C8I07_RS05075	COG2863	cytochrome
C8I07_RS05110	COG0527	aspartate kinase activity
C8I07_RS05110	COG0460	homoserine dehydrogenase
C8I07_RS05115	COG0626	cystathionine gamma-synthase activity
C8I07_RS05120	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
C8I07_RS05130	COG3301	Polysulphide reductase, NrfD
C8I07_RS05135	COG0437	4 iron, 4 sulfur cluster binding
C8I07_RS05180	COG2226	methyltransferase
C8I07_RS05190	COG2200	EAL domain
C8I07_RS05190	COG2199	diguanylate cyclase activity
C8I07_RS05190	COG3287	FIST C domain
C8I07_RS05195	COG2968	Membrane
C8I07_RS05225	COG0312	modulator of DNA gyrase
C8I07_RS05230	COG3028	Belongs to the UPF0307 family
C8I07_RS05240	COG0531	amino acid
C8I07_RS05260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS05270	COG0312	modulator of DNA gyrase
C8I07_RS05275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8I07_RS05285	COG1530	ribonuclease E activity
C8I07_RS05295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C8I07_RS05300	COG1792	Involved in formation and maintenance of cell shape
C8I07_RS05305	COG1077	Cell shape determining protein MreB Mrl
C8I07_RS05340	COG2165	general secretion pathway protein
C8I07_RS05350	COG1459	type II secretion system
C8I07_RS05355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C8I07_RS05365	COG3267	Type II secretory pathway component ExeA
C8I07_RS05365	COG3409	Peptidoglycan-binding domain 1 protein
C8I07_RS05400	COG0281	malic enzyme
C8I07_RS05415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C8I07_RS05435	COG0330	HflC and HflK could
C8I07_RS05440	COG0330	HflC and HflK could
C8I07_RS05455	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C8I07_RS05475	COG0668	transmembrane transport
C8I07_RS05530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C8I07_RS05535	COG2165	general secretion pathway protein
C8I07_RS05560	COG3046	protein related to deoxyribodipyrimidine photolyase
C8I07_RS05570	COG3227	Zinc metalloprotease (Elastase)
C8I07_RS05575	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C8I07_RS05600	COG0564	pseudouridine synthase activity
C8I07_RS05625	COG1227	inorganic diphosphatase activity
C8I07_RS05660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C8I07_RS05665	COG0010	Belongs to the arginase family
C8I07_RS05695	COG0805	protein transport
C8I07_RS05705	COG0084	hydrolase, TatD family'
C8I07_RS05710	COG3706	GGDEF domain
C8I07_RS05710	COG2203	Gaf domain
C8I07_RS05710	COG5001	Diguanylate cyclase
C8I07_RS05710	COG4251	negative regulation of phosphorylation
C8I07_RS05720	COG3385	transposase activity
C8I07_RS05740	COG1049	propionate catabolic process, 2-methylcitrate cycle
C8I07_RS05745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C8I07_RS05760	COG1752	Esterase of the alpha-beta hydrolase superfamily
C8I07_RS05775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C8I07_RS05780	COG0508	dehydrogenase complex catalyzes the overall conversion of
C8I07_RS05785	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C8I07_RS05790	COG2186	Transcriptional regulator
C8I07_RS05800	COG3023	N-Acetylmuramoyl-L-alanine amidase
C8I07_RS05815	COG4969	Belongs to the N-Me-Phe pilin family
C8I07_RS05820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C8I07_RS05825	COG1459	type II secretion system
C8I07_RS05830	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C8I07_RS05835	COG0237	dephospho-CoA kinase activity
C8I07_RS05850	COG0494	nUDIX hydrolase
C8I07_RS05870	COG3118	belongs to the thioredoxin family
C8I07_RS05875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C8I07_RS05880	COG0583	DNA-binding transcription factor activity
C8I07_RS05885	COG0604	alcohol dehydrogenase
C8I07_RS05895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C8I07_RS05900	COG1053	succinate dehydrogenase
C8I07_RS05920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C8I07_RS05925	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C8I07_RS05930	COG0210	DNA helicase
C8I07_RS05935	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C8I07_RS05950	COG1011	Hydrolase
C8I07_RS05955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C8I07_RS05970	COG0019	diaminopimelate decarboxylase activity
C8I07_RS05985	COG3072	Adenylate cyclase
C8I07_RS05995	COG1587	Uroporphyrinogen-III synthase
C8I07_RS06000	COG2959	enzyme of heme biosynthesis
C8I07_RS06025	COG1538	Outer membrane efflux protein
C8I07_RS06070	COG0210	DNA helicase
C8I07_RS06090	COG3214	Protein conserved in bacteria
C8I07_RS06105	COG0671	phosphoesterase, PA-phosphatase related
C8I07_RS06115	COG1522	sequence-specific DNA binding
C8I07_RS06120	COG0733	neurotransmitter:sodium symporter activity
C8I07_RS06125	COG1609	Transcriptional regulator
C8I07_RS06130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8I07_RS06135	COG1879	ABC-type sugar transport system periplasmic component
C8I07_RS06140	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8I07_RS06145	COG1129	ABC transporter
C8I07_RS06150	COG1869	D-ribose catabolic process
C8I07_RS06170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C8I07_RS06175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C8I07_RS06185	COG0028	Belongs to the TPP enzyme family
C8I07_RS06200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C8I07_RS06205	COG0583	DNA-binding transcription factor activity
C8I07_RS06210	COG1253	flavin adenine dinucleotide binding
C8I07_RS06215	COG3706	GGDEF domain
C8I07_RS06215	COG5001	Diguanylate cyclase
C8I07_RS06215	COG2203	Gaf domain
C8I07_RS06215	COG4251	negative regulation of phosphorylation
C8I07_RS06220	COG1609	Transcriptional regulator
C8I07_RS06230	COG0606	chelatase, subunit chli
C8I07_RS06235	COG0204	Acyl-transferase
C8I07_RS06240	COG0204	Acyl-transferase
C8I07_RS06255	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C8I07_RS06265	COG0372	Belongs to the citrate synthase family
C8I07_RS06270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C8I07_RS06275	COG2828	Protein conserved in bacteria
C8I07_RS06290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C8I07_RS06310	COG0251	oxidation-reduction process
C8I07_RS06315	COG1757	Na H antiporter
C8I07_RS06335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C8I07_RS06365	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C8I07_RS06385	COG3706	GGDEF domain
C8I07_RS06415	COG1881	PFAM PEBP family protein
C8I07_RS06425	COG1982	Orn Lys Arg decarboxylase major
C8I07_RS06430	COG0531	amino acid
C8I07_RS06435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C8I07_RS06440	COG3265	gluconokinase activity
C8I07_RS06445	COG2610	gluconate transmembrane transporter activity
C8I07_RS06450	COG1609	Transcriptional regulator
C8I07_RS06455	COG1032	radical SAM domain protein
C8I07_RS06495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C8I07_RS06515	COG2823	Periplasmic or secreted lipoprotein
C8I07_RS06525	COG0583	DNA-binding transcription factor activity
C8I07_RS06530	COG0180	Tryptophanyl-tRNA synthetase
C8I07_RS06540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C8I07_RS06555	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C8I07_RS06600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C8I07_RS06615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C8I07_RS06630	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C8I07_RS06695	COG3383	formate dehydrogenase (NAD+) activity
C8I07_RS06695	COG0243	molybdopterin cofactor binding
C8I07_RS06700	COG0437	4 iron, 4 sulfur cluster binding
C8I07_RS06715	COG3383	formate dehydrogenase (NAD+) activity
C8I07_RS06715	COG0243	molybdopterin cofactor binding
C8I07_RS06720	COG0437	4 iron, 4 sulfur cluster binding
C8I07_RS06760	COG4771	TonB-dependent receptor
C8I07_RS06765	COG0583	DNA-binding transcription factor activity
C8I07_RS06780	COG0697	spore germination
C8I07_RS06790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C8I07_RS06800	COG0823	Involved in the tonB-independent uptake of proteins
C8I07_RS06800	COG1506	peptidase
C8I07_RS06810	COG0612	Peptidase, M16
C8I07_RS06815	COG1473	amidohydrolase
C8I07_RS06825	COG0583	DNA-binding transcription factor activity
C8I07_RS06900	COG0531	amino acid
C8I07_RS06905	COG1522	sequence-specific DNA binding
C8I07_RS06910	COG3301	Polysulphide reductase, NrfD
C8I07_RS06915	COG0437	4 iron, 4 sulfur cluster binding
C8I07_RS06945	COG1441	menaquinone biosynthetic process
C8I07_RS06950	COG0318	PFAM AMP-dependent synthetase and ligase
C8I07_RS06960	COG2177	Part of the ABC transporter FtsEX involved in
C8I07_RS06965	COG2884	Cell division ATP-binding protein ftsE
C8I07_RS06970	COG0552	protein localization to endoplasmic reticulum
C8I07_RS06975	COG0742	ribosomal rna small subunit methyltransferase
C8I07_RS06985	COG3005	denitrification pathway
C8I07_RS07015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8I07_RS07025	COG3719	Belongs to the RNase T2 family
C8I07_RS07055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C8I07_RS07065	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C8I07_RS07090	COG1612	heme a metabolic process
C8I07_RS07100	COG1999	signal sequence binding
C8I07_RS07110	COG0534	Mate efflux family protein
C8I07_RS07115	COG1506	peptidase
C8I07_RS07125	COG1040	competence protein
C8I07_RS07140	COG1368	sulfuric ester hydrolase activity
C8I07_RS07145	COG2183	response to ionizing radiation
C8I07_RS07150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C8I07_RS07200	COG3064	Membrane
C8I07_RS07215	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C8I07_RS07225	COG4208	sulfate ABC transporter
C8I07_RS07230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C8I07_RS07250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C8I07_RS07285	COG4232	protein-disulfide reductase activity
C8I07_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS07315	COG1595	DNA-templated transcription, initiation
C8I07_RS07325	COG4771	TonB-dependent receptor
C8I07_RS07345	COG0811	peptide transport
C8I07_RS07350	COG0848	biopolymer transport protein
C8I07_RS07360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C8I07_RS07370	COG5001	Diguanylate cyclase
C8I07_RS07370	COG3300	MHYT domain
C8I07_RS07375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C8I07_RS07380	COG0741	lytic transglycosylase activity
C8I07_RS07380	COG0739	heme binding
C8I07_RS07380	COG1196	nuclear chromosome segregation
C8I07_RS07395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C8I07_RS07410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8I07_RS07415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS07440	COG0339	signal peptide processing
C8I07_RS07455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C8I07_RS07465	COG1566	PFAM secretion protein HlyD family protein
C8I07_RS07470	COG1289	transmembrane transporter activity
C8I07_RS07475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8I07_RS07480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C8I07_RS07485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C8I07_RS07500	COG2855	membrane
C8I07_RS07565	COG1122	ATPase activity
C8I07_RS07570	COG4206	TonB-dependent receptor
C8I07_RS07575	COG1169	isochorismate synthase
C8I07_RS07585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C8I07_RS07595	COG3852	Histidine kinase
C8I07_RS07600	COG2204	response regulator
C8I07_RS07615	COG1136	(ABC) transporter
C8I07_RS07625	COG0303	'Molybdopterin
C8I07_RS07655	COG0297	glycogen (starch) synthase activity
C8I07_RS07655	COG0438	transferase activity, transferring glycosyl groups
C8I07_RS07660	COG1216	Glycosyl transferase, family 2
C8I07_RS07675	COG0859	PFAM glycosyl transferase family 9
C8I07_RS07680	COG3642	lipopolysaccharide core region biosynthetic process
C8I07_RS07685	COG1519	Transferase
C8I07_RS07705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C8I07_RS07710	COG0705	Rhomboid family
C8I07_RS07715	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C8I07_RS07745	COG3078	GTPase activator activity
C8I07_RS07755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C8I07_RS07770	COG2267	carboxylic ester hydrolase activity
C8I07_RS07775	COG5001	Diguanylate cyclase
C8I07_RS07795	COG4974	Belongs to the 'phage' integrase family
C8I07_RS07815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C8I07_RS07825	COG2856	Zn peptidase
C8I07_RS07875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8I07_RS07880	COG1349	DNA-binding transcription factor activity
C8I07_RS07885	COG4774	siderophore transport
C8I07_RS07935	COG3312	ion transport
C8I07_RS07940	COG1475	DNA binding
C8I07_RS07945	COG1192	Involved in chromosome partitioning
C8I07_RS07960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C8I07_RS07990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C8I07_RS08050	COG2204	response regulator
C8I07_RS08070	COG4974	Belongs to the 'phage' integrase family
C8I07_RS08120	COG0625	glutathione transferase activity
C8I07_RS08145	COG1984	allophanate hydrolase subunit 2
C8I07_RS08150	COG1639	'signal transduction protein
C8I07_RS08165	COG2818	Glycosylase
C8I07_RS08170	COG0804	urea catabolic process
C8I07_RS08195	COG0183	Belongs to the thiolase family
C8I07_RS08210	COG1739	Uncharacterized protein family UPF0029
C8I07_RS08215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C8I07_RS08220	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C8I07_RS08225	COG0640	Transcriptional regulator
C8I07_RS08235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C8I07_RS08240	COG0569	domain protein
C8I07_RS08245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C8I07_RS08245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C8I07_RS08255	COG0242	peptide deformylase activity
C8I07_RS08265	COG0758	DNA mediated transformation
C8I07_RS08275	COG0551	DNA topoisomerase type I activity
C8I07_RS08305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C8I07_RS08335	COG1959	2 iron, 2 sulfur cluster binding
C8I07_RS08340	COG2861	carbohydrate metabolic process
C8I07_RS08345	COG0793	Belongs to the peptidase S41A family
C8I07_RS08350	COG4942	peptidase
C8I07_RS08360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C8I07_RS08375	COG2081	HI0933 family
C8I07_RS08400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C8I07_RS08405	COG0569	domain protein
C8I07_RS08410	COG0745	RESPONSE REGULATOR receiver
C8I07_RS08415	COG2205	protein histidine kinase activity
C8I07_RS08425	COG3275	phosphorelay sensor kinase activity
C8I07_RS08430	COG3279	Response regulator of the LytR AlgR family
C8I07_RS08435	COG2223	nitrite transmembrane transporter activity
C8I07_RS08445	COG0791	NLP P60 protein
C8I07_RS08450	COG0477	Major facilitator Superfamily
C8I07_RS08455	COG1609	Transcriptional regulator
C8I07_RS08475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8I07_RS08480	COG0521	Mo-molybdopterin cofactor biosynthetic process
C8I07_RS08490	COG1668	transmembrane transport
C8I07_RS08495	COG4555	ABC transporter
C8I07_RS08505	COG2188	Transcriptional regulator
C8I07_RS08510	COG1131	(ABC) transporter
C8I07_RS08520	COG1022	Amp-dependent synthetase and ligase
C8I07_RS08555	COG0789	Transcriptional regulator
C8I07_RS08560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C8I07_RS08635	COG2986	histidine ammonia-lyase
C8I07_RS08640	COG3383	formate dehydrogenase (NAD+) activity
C8I07_RS08640	COG0243	molybdopterin cofactor binding
C8I07_RS08645	COG3383	formate dehydrogenase (NAD+) activity
C8I07_RS08645	COG0243	molybdopterin cofactor binding
C8I07_RS08650	COG0437	4 iron, 4 sulfur cluster binding
C8I07_RS08655	COG2864	formate dehydrogenase
C8I07_RS08665	COG1921	L-seryl-tRNASec selenium transferase activity
C8I07_RS08670	COG3276	selenocysteine insertion sequence binding
C8I07_RS08675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C8I07_RS08680	COG2391	methyltransferase activity
C8I07_RS08685	COG0425	Belongs to the sulfur carrier protein TusA family
C8I07_RS08700	COG0346	lactoylglutathione lyase activity
C8I07_RS08725	COG0668	transmembrane transport
C8I07_RS08730	COG1280	lysine exporter protein (LysE YggA)
C8I07_RS08760	COG2095	MarC family integral membrane protein
C8I07_RS08775	COG1580	Controls the rotational direction of flagella during chemotaxis
C8I07_RS08795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C8I07_RS08800	COG0303	'Molybdopterin
C8I07_RS08805	COG1528	Iron-storage protein
C8I07_RS08820	COG1770	oligopeptidase
C8I07_RS08845	COG2226	methyltransferase
C8I07_RS08860	COG1301	dicarboxylic acid transport
C8I07_RS08875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C8I07_RS08880	COG3031	protein transport across the cell outer membrane
C8I07_RS08890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C8I07_RS08895	COG1459	type II secretion system
C8I07_RS08900	COG2165	general secretion pathway protein
C8I07_RS08910	COG2165	general secretion pathway protein
C8I07_RS08915	COG4795	General secretion pathway protein
C8I07_RS08920	COG3156	type II secretion system protein K
C8I07_RS08940	COG1011	Hydrolase
C8I07_RS08975	COG0494	nUDIX hydrolase
C8I07_RS08980	COG1218	3'(2'),5'-bisphosphate nucleotidase
C8I07_RS08995	COG2814	Major facilitator Superfamily
C8I07_RS09065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C8I07_RS09065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C8I07_RS09100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C8I07_RS09175	COG0089	rRNA binding
C8I07_RS09185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C8I07_RS09190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C8I07_RS09200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C8I07_RS09265	COG0201	protein transport
C8I07_RS09270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C8I07_RS09280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C8I07_RS09310	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C8I07_RS09315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C8I07_RS09320	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C8I07_RS09335	COG3088	subunit of a heme lyase
C8I07_RS09335	COG4235	cytochrome complex assembly
C8I07_RS09350	COG3088	subunit of a heme lyase
C8I07_RS09350	COG4235	cytochrome complex assembly
C8I07_RS09355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C8I07_RS09450	COG3284	Transcriptional regulator
C8I07_RS09455	COG0604	alcohol dehydrogenase
C8I07_RS09460	COG2205	protein histidine kinase activity
C8I07_RS09465	COG0745	RESPONSE REGULATOR receiver
C8I07_RS09470	COG3678	ATP-independent chaperone mediated protein folding
C8I07_RS09490	COG2204	response regulator
C8I07_RS09495	COG3852	Histidine kinase
C8I07_RS09515	COG1979	alcohol dehydrogenase
C8I07_RS09520	COG1309	transcriptional regulator
C8I07_RS09530	COG0840	transmembrane signaling receptor activity
C8I07_RS09535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C8I07_RS09560	COG2258	MOSC domain
C8I07_RS09570	COG0840	transmembrane signaling receptor activity
C8I07_RS09580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C8I07_RS09590	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C8I07_RS09595	COG0314	molybdopterin synthase activity
C8I07_RS09600	COG0725	ABC transporter, periplasmic molybdate-binding protein
C8I07_RS09610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C8I07_RS09630	COG0745	RESPONSE REGULATOR receiver
C8I07_RS09635	COG5002	protein histidine kinase activity
C8I07_RS09640	COG0564	pseudouridine synthase activity
C8I07_RS09685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C8I07_RS09695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C8I07_RS09715	COG0174	glutamine synthetase
C8I07_RS09720	COG1217	gtp-binding protein TYPA
C8I07_RS09730	COG2203	Gaf domain
C8I07_RS09730	COG3706	GGDEF domain
C8I07_RS09730	COG4251	negative regulation of phosphorylation
C8I07_RS09730	COG5001	Diguanylate cyclase
C8I07_RS09735	COG0348	domain, Protein
C8I07_RS09740	COG5433	transposase activity
C8I07_RS09745	COG3293	Transposase
C8I07_RS09750	COG5433	transposase activity
C8I07_RS09755	COG0457	Tetratricopeptide repeat
C8I07_RS09760	COG0653	protein targeting
C8I07_RS09765	COG0653	protein targeting
C8I07_RS09800	COG0456	acetyltransferase
C8I07_RS09820	COG1396	sequence-specific DNA binding
C8I07_RS09825	COG3135	benzoate transporter
C8I07_RS09830	COG0840	transmembrane signaling receptor activity
C8I07_RS09840	COG0454	-acetyltransferase
C8I07_RS09855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8I07_RS09860	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS09925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8I07_RS09930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8I07_RS09950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C8I07_RS09955	COG2197	response regulator
C8I07_RS09960	COG4585	Histidine kinase
C8I07_RS09985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C8I07_RS09995	COG0194	GDP metabolic process
C8I07_RS10030	COG1061	Type III restriction enzyme res subunit
C8I07_RS10035	COG0583	DNA-binding transcription factor activity
C8I07_RS10040	COG1011	Hydrolase
C8I07_RS10065	COG1561	YicC-like family, N-terminal region
C8I07_RS10080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C8I07_RS10090	COG1506	peptidase
C8I07_RS10105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C8I07_RS10115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C8I07_RS10120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C8I07_RS10125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C8I07_RS10125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C8I07_RS10135	COG2962	Rard protein
C8I07_RS10145	COG0514	ATP-dependent DNA helicase (RecQ)
C8I07_RS10160	COG0473	3-isopropylmalate dehydrogenase activity
C8I07_RS10175	COG2067	long-chain fatty acid transport protein
C8I07_RS10200	COG3116	cell division
C8I07_RS10205	COG0768	penicillin binding
C8I07_RS10210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C8I07_RS10215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C8I07_RS10225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C8I07_RS10230	COG0772	Belongs to the SEDS family
C8I07_RS10245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C8I07_RS10250	COG0849	cell division
C8I07_RS10255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C8I07_RS10270	COG1196	nuclear chromosome segregation
C8I07_RS10270	COG0741	lytic transglycosylase activity
C8I07_RS10270	COG0739	heme binding
C8I07_RS10335	COG5002	protein histidine kinase activity
C8I07_RS10335	COG5001	Diguanylate cyclase
C8I07_RS10340	COG0300	oxidoreductase activity
C8I07_RS10355	COG0151	Belongs to the GarS family
C8I07_RS10360	COG0138	bifunctional purine biosynthesis protein purh
C8I07_RS10365	COG0789	Transcriptional regulator
C8I07_RS10370	COG0701	Predicted permease
C8I07_RS10395	COG0471	metal ion transport
C8I07_RS10400	COG3118	belongs to the thioredoxin family
C8I07_RS10425	COG2358	TRAP transporter, solute receptor (TAXI family
C8I07_RS10435	COG0433	COG0433 Predicted ATPase
C8I07_RS10450	COG2321	neutral zinc metallopeptidase
C8I07_RS10475	COG0210	DNA helicase
C8I07_RS10485	COG1879	ABC-type sugar transport system periplasmic component
C8I07_RS10500	COG3118	belongs to the thioredoxin family
C8I07_RS10505	COG0628	permease
C8I07_RS10520	COG3590	peptidase
C8I07_RS10530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C8I07_RS10565	COG2814	Major facilitator Superfamily
C8I07_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS10575	COG0511	ligase activity, forming carbon-carbon bonds
C8I07_RS10650	COG2153	protein acetylation
C8I07_RS10670	COG1335	isochorismatase
C8I07_RS10675	COG4977	sequence-specific DNA binding
C8I07_RS10685	COG1280	lysine exporter protein (LysE YggA)
C8I07_RS10690	COG0640	Transcriptional regulator
C8I07_RS10695	COG0798	PFAM Bile acid sodium symporter
C8I07_RS10710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C8I07_RS10725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C8I07_RS10730	COG1115	amino acid carrier protein
C8I07_RS10750	COG4251	negative regulation of phosphorylation
C8I07_RS10755	COG2197	response regulator
C8I07_RS10785	COG0745	RESPONSE REGULATOR receiver
C8I07_RS10815	COG2200	EAL domain
C8I07_RS10830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C8I07_RS10840	COG4989	oxidoreductase activity
C8I07_RS10850	COG0668	transmembrane transport
C8I07_RS10890	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C8I07_RS10895	COG3706	GGDEF domain
C8I07_RS10900	COG2201	protein-glutamate methylesterase activity
C8I07_RS10905	COG1024	Enoyl-CoA hydratase
C8I07_RS10920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C8I07_RS10955	COG0840	transmembrane signaling receptor activity
C8I07_RS10970	COG0584	glycerophosphoryl diester phosphodiesterase
C8I07_RS10975	COG3264	Mechanosensitive ion channel
C8I07_RS10975	COG1511	domain protein
C8I07_RS10980	COG0697	spore germination
C8I07_RS10990	COG1162	GTPase activity
C8I07_RS11025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C8I07_RS11025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C8I07_RS11030	COG0802	atpase or kinase
C8I07_RS11055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C8I07_RS11060	COG0330	HflC and HflK could
C8I07_RS11065	COG0330	HflC and HflK could
C8I07_RS11070	COG0723	plastoquinol--plastocyanin reductase activity
C8I07_RS11075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C8I07_RS11080	COG2857	Cytochrome c1
C8I07_RS11085	COG0625	glutathione transferase activity
C8I07_RS11090	COG2969	positive regulation of protein catabolic process
C8I07_RS11115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C8I07_RS11150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8I07_RS11160	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C8I07_RS11165	COG5001	Diguanylate cyclase
C8I07_RS11165	COG5002	protein histidine kinase activity
C8I07_RS11170	COG1643	Atp-dependent helicase
C8I07_RS11175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C8I07_RS11180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C8I07_RS11225	COG4566	intracellular signal transduction
C8I07_RS11250	COG1301	dicarboxylic acid transport
C8I07_RS11280	COG0745	RESPONSE REGULATOR receiver
C8I07_RS11290	COG0527	aspartate kinase activity
C8I07_RS11310	COG2197	response regulator
C8I07_RS11315	COG3850	Histidine kinase
C8I07_RS11335	COG0004	ammonium transporteR
C8I07_RS11350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C8I07_RS11360	COG5265	(ABC) transporter
C8I07_RS11375	COG0069	glutamate synthase activity
C8I07_RS11390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8I07_RS11405	COG1840	ABC-type Fe3 transport system, periplasmic component
C8I07_RS11415	COG3842	ATPase activity
C8I07_RS11420	COG0405	Gamma-glutamyltransferase
C8I07_RS11425	COG2837	iron assimilation
C8I07_RS11430	COG0583	DNA-binding transcription factor activity
C8I07_RS11435	COG2910	NAD(P)H-binding
C8I07_RS11460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C8I07_RS11470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C8I07_RS11475	COG3079	Belongs to the UPF0149 family
C8I07_RS11480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8I07_RS11485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8I07_RS11505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C8I07_RS11525	COG3081	Nucleoid-associated protein
C8I07_RS11545	COG1064	alcohol dehydrogenase
C8I07_RS11595	COG1944	ATP diphosphatase activity
C8I07_RS11600	COG3706	GGDEF domain
C8I07_RS11625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C8I07_RS11635	COG0534	Mate efflux family protein
C8I07_RS11675	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C8I07_RS11680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8I07_RS11700	COG4206	TonB-dependent receptor
C8I07_RS11715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C8I07_RS11720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C8I07_RS11730	COG3706	GGDEF domain
C8I07_RS11750	COG4807	Protein conserved in bacteria
C8I07_RS11785	COG3590	peptidase
C8I07_RS11795	COG1187	pseudouridine synthase activity
C8I07_RS11820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C8I07_RS11845	COG2890	protein-(glutamine-N5) methyltransferase activity
C8I07_RS11880	COG2200	EAL domain
C8I07_RS11885	COG0004	ammonium transporteR
C8I07_RS11890	COG0347	Belongs to the P(II) protein family
C8I07_RS11895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C8I07_RS11910	COG2211	Major facilitator Superfamily
C8I07_RS11950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C8I07_RS11955	COG0163	prenyltransferase activity
C8I07_RS11965	COG1131	(ABC) transporter
C8I07_RS11970	COG0842	Transport permease protein
C8I07_RS11990	COG1522	sequence-specific DNA binding
C8I07_RS11995	COG0564	pseudouridine synthase activity
C8I07_RS12000	COG0826	peptidase U32
C8I07_RS12020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C8I07_RS12030	COG2166	iron-sulfur cluster assembly
C8I07_RS12035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C8I07_RS12040	COG0840	transmembrane signaling receptor activity
C8I07_RS12065	COG0745	RESPONSE REGULATOR receiver
C8I07_RS12080	COG3713	MltA-interacting MipA family protein
C8I07_RS12085	COG0667	Aldo Keto reductase
C8I07_RS12090	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8I07_RS12095	COG1805	sodium ion transport
C8I07_RS12100	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8I07_RS12105	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8I07_RS12110	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8I07_RS12115	COG2871	sodium ion transport
C8I07_RS12145	COG2366	antibiotic biosynthetic process
C8I07_RS12155	COG0814	amino acid
C8I07_RS12170	COG1301	dicarboxylic acid transport
C8I07_RS12215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C8I07_RS12230	COG0191	fructose-bisphosphate aldolase activity
C8I07_RS12280	COG0513	Belongs to the DEAD box helicase family
C8I07_RS12295	COG4974	Belongs to the 'phage' integrase family
C8I07_RS12300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C8I07_RS12305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C8I07_RS12315	COG3634	alkyl hydroperoxide reductase activity
C8I07_RS12325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C8I07_RS12370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C8I07_RS12375	COG1053	succinate dehydrogenase
C8I07_RS12405	COG1764	response to oxidative stress
C8I07_RS12410	COG1846	Transcriptional regulator
C8I07_RS12415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C8I07_RS12435	COG3383	formate dehydrogenase (NAD+) activity
C8I07_RS12450	COG1966	Carbon starvation protein
C8I07_RS12465	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C8I07_RS12470	COG0306	phosphate transporter
C8I07_RS12480	COG1801	Protein of unknown function DUF72
C8I07_RS12510	COG0242	peptide deformylase activity
C8I07_RS12525	COG0545	Peptidyl-prolyl cis-trans isomerase
C8I07_RS12540	COG2050	protein possibly involved in aromatic compounds catabolism
C8I07_RS12555	COG2119	membrane
C8I07_RS12560	COG3397	chitin binding
C8I07_RS12565	COG0814	amino acid
C8I07_RS12570	COG4990	cell redox homeostasis
C8I07_RS12570	COG3591	Belongs to the peptidase S1B family
C8I07_RS12615	COG1187	pseudouridine synthase activity
C8I07_RS12620	COG1757	Na H antiporter
C8I07_RS12630	COG0840	transmembrane signaling receptor activity
C8I07_RS12635	COG0697	spore germination
C8I07_RS12645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C8I07_RS12655	COG1294	oxidase, subunit
C8I07_RS12660	COG1271	oxidase subunit
C8I07_RS12665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8I07_RS12670	COG2873	o-acetylhomoserine
C8I07_RS12690	COG0271	Belongs to the BolA IbaG family
C8I07_RS12710	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8I07_RS12715	COG1805	sodium ion transport
C8I07_RS12720	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8I07_RS12730	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8I07_RS12735	COG2871	sodium ion transport
C8I07_RS12740	COG1477	protein flavinylation
C8I07_RS12745	COG2991	Protein conserved in bacteria
C8I07_RS12755	COG2193	ferroxidase activity
C8I07_RS12770	COG0583	DNA-binding transcription factor activity
C8I07_RS12775	COG0697	spore germination
C8I07_RS12780	COG0840	transmembrane signaling receptor activity
C8I07_RS12790	COG2195	Cleaves the N-terminal amino acid of tripeptides
C8I07_RS12795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C8I07_RS12825	COG2252	PERMEase
C8I07_RS12830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C8I07_RS12835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C8I07_RS12845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C8I07_RS12880	COG0513	Belongs to the DEAD box helicase family
C8I07_RS12895	COG0545	Peptidyl-prolyl cis-trans isomerase
C8I07_RS12905	COG0505	Belongs to the CarA family
C8I07_RS12910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C8I07_RS12915	COG0564	pseudouridine synthase activity
C8I07_RS12930	COG2239	Acts as a magnesium transporter
C8I07_RS12955	COG3220	belongs to the UPF0276 family
C8I07_RS12975	COG2354	Protein conserved in bacteria
C8I07_RS12990	COG0653	protein targeting
C8I07_RS13010	COG1085	galactose-1-phosphate uridylyltransferase
C8I07_RS13015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C8I07_RS13040	COG1609	Transcriptional regulator
C8I07_RS13060	COG0783	Belongs to the Dps family
C8I07_RS13090	COG1686	Belongs to the peptidase S11 family
C8I07_RS13095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C8I07_RS13100	COG2951	lytic endotransglycosylase activity
C8I07_RS13105	COG0772	Belongs to the SEDS family
C8I07_RS13110	COG0768	penicillin binding
C8I07_RS13120	COG0799	negative regulation of ribosome biogenesis
C8I07_RS13135	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C8I07_RS13155	COG2165	general secretion pathway protein
C8I07_RS13160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C8I07_RS13165	COG4535	Mg2 and Co2 transporter CorC
C8I07_RS13175	COG1702	phosphate starvation-inducible protein PhoH
C8I07_RS13190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8I07_RS13270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C8I07_RS13275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C8I07_RS13280	COG1534	Rna-binding protein
C8I07_RS13295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C8I07_RS13310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C8I07_RS13330	COG0195	Participates in both transcription termination and antitermination
C8I07_RS13380	COG0084	hydrolase, TatD family'
C8I07_RS13385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C8I07_RS13420	COG0560	Phosphoserine phosphatase
C8I07_RS13445	COG0745	RESPONSE REGULATOR receiver
C8I07_RS13455	COG2205	protein histidine kinase activity
C8I07_RS13455	COG2198	Histidine kinase
C8I07_RS13455	COG0784	Response regulator, receiver
C8I07_RS13470	COG3005	denitrification pathway
C8I07_RS13480	COG2252	PERMEase
C8I07_RS13485	COG0617	tRNA 3'-terminal CCA addition
C8I07_RS13485	COG0517	IMP dehydrogenase activity
C8I07_RS13485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C8I07_RS13510	COG3314	Sporulation integral membrane protein YlbJ
C8I07_RS13520	COG0826	peptidase U32
C8I07_RS13525	COG0826	peptidase U32
C8I07_RS13530	COG3154	lipid carrier protein
C8I07_RS13535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C8I07_RS13540	COG0826	peptidase U32
C8I07_RS13555	COG0824	Thioesterase
C8I07_RS13560	COG0784	Response regulator, receiver
C8I07_RS13560	COG0835	chemotaxis
C8I07_RS13565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C8I07_RS13570	COG0583	DNA-binding transcription factor activity
C8I07_RS13630	COG2971	BadF BadG BcrA BcrD
C8I07_RS13635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8I07_RS13640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C8I07_RS13670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C8I07_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
C8I07_RS13680	COG2186	Transcriptional regulator
C8I07_RS13695	COG3976	FMN-binding domain protein
C8I07_RS13695	COG1053	succinate dehydrogenase
C8I07_RS13705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C8I07_RS13710	COG2897	thiosulfate sulfurtransferase activity
C8I07_RS13720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8I07_RS13730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C8I07_RS13745	COG3842	ATPase activity
C8I07_RS13750	COG1176	ABC-type spermidine putrescine transport system, permease component I
C8I07_RS13755	COG1177	transmembrane transport
C8I07_RS13760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8I07_RS13765	COG1012	belongs to the aldehyde dehydrogenase family
C8I07_RS13775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8I07_RS13820	COG1609	Transcriptional regulator
C8I07_RS13825	COG2211	Major facilitator Superfamily
C8I07_RS13830	COG2723	6-phospho-beta-galactosidase activity
C8I07_RS13840	COG1472	Belongs to the glycosyl hydrolase 3 family
C8I07_RS13845	COG1940	carbohydrate kinase activity
C8I07_RS13850	COG0840	transmembrane signaling receptor activity
C8I07_RS13900	COG3550	peptidyl-serine autophosphorylation
C8I07_RS13905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C8I07_RS13910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C8I07_RS13970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C8I07_RS13980	COG1610	YqeY-like protein
C8I07_RS13985	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C8I07_RS14000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C8I07_RS14005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C8I07_RS14015	COG2226	methyltransferase
C8I07_RS14030	COG3409	Peptidoglycan-binding domain 1 protein
C8I07_RS14030	COG3267	Type II secretory pathway component ExeA
C8I07_RS14055	COG0540	Belongs to the ATCase OTCase family
C8I07_RS14085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C8I07_RS14100	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
C8I07_RS14120	COG0460	homoserine dehydrogenase
C8I07_RS14120	COG0527	aspartate kinase activity
C8I07_RS14130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C8I07_RS14145	COG4946	Tricorn protease homolog
C8I07_RS14145	COG0793	Belongs to the peptidase S41A family
C8I07_RS14185	COG0840	transmembrane signaling receptor activity
C8I07_RS14200	COG2197	response regulator
C8I07_RS14205	COG4585	Histidine kinase
C8I07_RS14220	COG0217	transcriptional regulatory protein
C8I07_RS14230	COG0840	transmembrane signaling receptor activity
C8I07_RS14245	COG1902	pentaerythritol trinitrate reductase activity
C8I07_RS14250	COG1067	ATP-dependent peptidase activity
C8I07_RS14260	COG0513	Belongs to the DEAD box helicase family
C8I07_RS14275	COG2867	negative regulation of translational initiation
C8I07_RS14280	COG2914	Belongs to the UPF0125 (RnfH) family
C8I07_RS14285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8I07_RS14315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C8I07_RS14325	COG1607	acyl-coa hydrolase
C8I07_RS14340	COG1454	alcohol dehydrogenase
C8I07_RS14375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C8I07_RS14380	COG1640	4-alpha-glucanotransferase
C8I07_RS14395	COG0058	SHG alpha-glucan phosphorylase activity
C8I07_RS14415	COG0513	Belongs to the DEAD box helicase family
C8I07_RS14420	COG0523	cobalamin synthesis protein
C8I07_RS14440	COG0534	Mate efflux family protein
C8I07_RS14465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C8I07_RS14475	COG1139	Iron-sulfur cluster binding protein
C8I07_RS14480	COG0247	lactate metabolic process
C8I07_RS14490	COG1620	l-lactate permease
C8I07_RS14510	COG0583	DNA-binding transcription factor activity
C8I07_RS14520	COG2363	Small membrane protein
C8I07_RS14530	COG0473	3-isopropylmalate dehydrogenase activity
C8I07_RS14535	COG1506	peptidase
C8I07_RS14535	COG0823	Involved in the tonB-independent uptake of proteins
C8I07_RS14535	COG4946	Tricorn protease homolog
C8I07_RS14550	COG1611	Belongs to the LOG family
C8I07_RS14585	COG5002	protein histidine kinase activity
C8I07_RS14600	COG0386	Belongs to the glutathione peroxidase family
C8I07_RS14605	COG2239	Acts as a magnesium transporter
C8I07_RS14625	COG3706	GGDEF domain
C8I07_RS14625	COG5001	Diguanylate cyclase
C8I07_RS14625	COG2203	Gaf domain
C8I07_RS14625	COG4251	negative regulation of phosphorylation
C8I07_RS14645	COG0590	tRNA wobble adenosine to inosine editing
C8I07_RS14670	COG1294	oxidase, subunit
C8I07_RS14675	COG4890	Cyd operon protein YbgT
C8I07_RS14755	COG0835	chemotaxis
C8I07_RS14755	COG0784	Response regulator, receiver
C8I07_RS14760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C8I07_RS14765	COG1815	bacterial-type flagellum-dependent cell motility
C8I07_RS14780	COG1749	Flagellar hook protein flgE
C8I07_RS14785	COG4787	bacterial-type flagellum-dependent cell motility
C8I07_RS14790	COG4786	Flagellar basal body rod
C8I07_RS14805	COG1705	Flagellar rod assembly protein muramidase FlgJ
C8I07_RS14805	COG3951	Flagellar rod assembly protein muramidase FlgJ
C8I07_RS14815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C8I07_RS14830	COG1334	flagellar protein FlaG
C8I07_RS14835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C8I07_RS14845	COG1516	flagellar protein fliS
C8I07_RS14865	COG1677	Flagellar hook-basal body complex protein FliE
C8I07_RS14875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C8I07_RS14925	COG1987	bacterial-type flagellum assembly
C8I07_RS14965	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C8I07_RS14970	COG0784	Response regulator, receiver
C8I07_RS14970	COG2198	Histidine kinase
C8I07_RS14970	COG0643	Histidine kinase
C8I07_RS14985	COG1192	Involved in chromosome partitioning
C8I07_RS14995	COG0835	chemotaxis
C8I07_RS15005	COG2257	FlhB HrpN YscU SpaS Family
C8I07_RS15020	COG2853	Lipoprotein
C8I07_RS15025	COG0745	RESPONSE REGULATOR receiver
C8I07_RS15030	COG3104	oligopeptide transport
C8I07_RS15035	COG0250	Participates in transcription elongation, termination and antitermination
C8I07_RS15070	COG1086	Polysaccharide biosynthesis protein
C8I07_RS15095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C8I07_RS15110	COG1088	dTDP-glucose 4,6-dehydratase activity
C8I07_RS15125	COG0784	Response regulator, receiver
C8I07_RS15125	COG3437	response regulator, receiver
C8I07_RS15130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8I07_RS15130	COG4191	Histidine kinase
C8I07_RS15145	COG1902	pentaerythritol trinitrate reductase activity
C8I07_RS15150	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8I07_RS15175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C8I07_RS15180	COG4753	response regulator
C8I07_RS15180	COG2207	Transcriptional regulator
C8I07_RS15190	COG0110	maltose O-acetyltransferase activity
C8I07_RS15195	COG1720	tRNA m6t6A37 methyltransferase activity
C8I07_RS15210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C8I07_RS15230	COG1757	Na H antiporter
C8I07_RS15235	COG0339	signal peptide processing
C8I07_RS15245	COG1435	thymidine kinase activity
C8I07_RS15265	COG2133	pyrroloquinoline quinone binding
C8I07_RS15290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C8I07_RS15295	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C8I07_RS15305	COG4770	biotin carboxylase activity
C8I07_RS15310	COG1024	Enoyl-CoA hydratase
C8I07_RS15315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8I07_RS15320	COG1960	acyl-CoA dehydrogenase activity
C8I07_RS15335	COG2076	Multidrug Resistance protein
C8I07_RS15340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C8I07_RS15355	COG3385	transposase activity
C8I07_RS15370	COG3384	dioxygenase
C8I07_RS15375	COG1575	Belongs to the MenA family. Type 1 subfamily
C8I07_RS15380	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS15385	COG1946	Acyl-CoA thioesterase
C8I07_RS15395	COG0583	DNA-binding transcription factor activity
C8I07_RS15400	COG2814	Major facilitator Superfamily
C8I07_RS15430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8I07_RS15440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8I07_RS15540	COG1132	(ABC) transporter
C8I07_RS15550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C8I07_RS15555	COG0513	Belongs to the DEAD box helicase family
C8I07_RS15565	COG0835	chemotaxis
C8I07_RS15565	COG0784	Response regulator, receiver
C8I07_RS15570	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C8I07_RS15590	COG0564	pseudouridine synthase activity
C8I07_RS15615	COG1862	Preprotein translocase
C8I07_RS15620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C8I07_RS15625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C8I07_RS15640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C8I07_RS15640	COG1648	precorrin-2 dehydrogenase activity
C8I07_RS15645	COG4681	YaeQ
C8I07_RS15655	COG1404	Belongs to the peptidase S8 family
C8I07_RS15660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C8I07_RS15665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C8I07_RS15680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS15695	COG2067	long-chain fatty acid transport protein
C8I07_RS15710	COG1595	DNA-templated transcription, initiation
C8I07_RS15720	COG2304	oxidoreductase activity
C8I07_RS15740	COG0714	Associated with various cellular activities
C8I07_RS15775	COG3300	MHYT domain
C8I07_RS15775	COG5001	Diguanylate cyclase
C8I07_RS15785	COG2062	phosphohistidine phosphatase, SixA
C8I07_RS15795	COG2890	protein-(glutamine-N5) methyltransferase activity
C8I07_RS15805	COG2211	Major facilitator Superfamily
C8I07_RS15830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8I07_RS15840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C8I07_RS15855	COG0285	dihydrofolate synthase activity
C8I07_RS15860	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C8I07_RS15865	COG1286	toxin biosynthetic process
C8I07_RS15870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C8I07_RS15890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C8I07_RS15895	COG0840	transmembrane signaling receptor activity
C8I07_RS15900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C8I07_RS15975	COG1982	Orn Lys Arg decarboxylase major
C8I07_RS15980	COG1982	Orn Lys Arg decarboxylase major
C8I07_RS15985	COG0708	Exodeoxyribonuclease III
C8I07_RS15990	COG2350	Protein conserved in bacteria
C8I07_RS16020	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C8I07_RS16045	COG0134	indole-3-glycerol-phosphate synthase activity
C8I07_RS16045	COG0135	phosphoribosylanthranilate isomerase activity
C8I07_RS16055	COG0512	Glutamine amidotransferase of anthranilate synthase
C8I07_RS16060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C8I07_RS16070	COG0009	L-threonylcarbamoyladenylate synthase
C8I07_RS16075	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C8I07_RS16080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C8I07_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS16100	COG2267	carboxylic ester hydrolase activity
C8I07_RS16105	COG0616	signal peptide processing
C8I07_RS16130	COG4181	ATPase activity
C8I07_RS16135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C8I07_RS16140	COG0681	Belongs to the peptidase S26 family
C8I07_RS16145	COG0786	glutamate:sodium symporter activity
C8I07_RS16150	COG1090	epimerase
C8I07_RS16155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C8I07_RS16160	COG0628	permease
C8I07_RS16165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C8I07_RS16185	COG0280	phosphate acetyltransferase
C8I07_RS16185	COG0857	belongs to the CobB CobQ family
C8I07_RS16195	COG3092	negative regulation of chromosome organization
C8I07_RS16200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C8I07_RS16205	COG1882	Formate acetyltransferase
C8I07_RS16210	COG2116	formate transmembrane transporter activity
C8I07_RS16215	COG4771	TonB-dependent receptor
C8I07_RS16225	COG3293	Transposase
C8I07_RS16235	COG2813	Specifically methylates the guanine in position
C8I07_RS16240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C8I07_RS16245	COG1714	RDD family
C8I07_RS16260	COG1196	nuclear chromosome segregation
C8I07_RS16300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8I07_RS16310	COG2176	DNA-directed DNA polymerase activity
C8I07_RS16320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8I07_RS16330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C8I07_RS16360	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C8I07_RS16370	COG0339	signal peptide processing
C8I07_RS16380	COG0456	acetyltransferase
C8I07_RS16390	COG0339	signal peptide processing
C8I07_RS16410	COG0405	Gamma-glutamyltransferase
C8I07_RS16420	COG1280	lysine exporter protein (LysE YggA)
C8I07_RS16425	COG0110	maltose O-acetyltransferase activity
C8I07_RS16435	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C8I07_RS16440	COG0583	DNA-binding transcription factor activity
C8I07_RS16470	COG0318	PFAM AMP-dependent synthetase and ligase
C8I07_RS16490	COG0596	Alpha beta hydrolase
C8I07_RS16515	COG3806	Anti-sigma factor
C8I07_RS16520	COG1595	DNA-templated transcription, initiation
C8I07_RS16530	COG2226	methyltransferase
C8I07_RS16535	COG0784	Response regulator, receiver
C8I07_RS16535	COG0835	chemotaxis
C8I07_RS16550	COG2951	lytic endotransglycosylase activity
C8I07_RS16560	COG0308	aminopeptidase N
C8I07_RS16570	COG0400	carboxylic ester hydrolase activity
C8I07_RS16575	COG0737	Belongs to the 5'-nucleotidase family
C8I07_RS16590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C8I07_RS16605	COG3220	belongs to the UPF0276 family
C8I07_RS16620	COG2832	Protein of unknown function (DUF454)
C8I07_RS16630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C8I07_RS16645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C8I07_RS16645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8I07_RS16695	COG0488	(ABC) transporter
C8I07_RS16705	COG3130	regulation of translation
C8I07_RS16715	COG1067	ATP-dependent peptidase activity
C8I07_RS16725	COG0840	transmembrane signaling receptor activity
C8I07_RS16740	COG2197	response regulator
C8I07_RS16750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C8I07_RS16775	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C8I07_RS16795	COG1279	arginine transmembrane transporter activity
C8I07_RS16800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C8I07_RS16805	COG2716	regulation of RNA biosynthetic process
C8I07_RS16815	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C8I07_RS16825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8I07_RS16835	COG3118	belongs to the thioredoxin family
C8I07_RS16845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C8I07_RS16855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8I07_RS16900	COG1902	pentaerythritol trinitrate reductase activity
C8I07_RS16905	COG3083	sulfuric ester hydrolase activity
C8I07_RS16910	COG3082	Protein of unknown function (DUF1414)
C8I07_RS16920	COG1858	cytochrome C peroxidase
C8I07_RS16945	COG3102	Protein conserved in bacteria
C8I07_RS16955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8I07_RS16985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS17000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C8I07_RS17005	COG1053	succinate dehydrogenase
C8I07_RS17015	COG0567	Dehydrogenase, E1 component
C8I07_RS17020	COG0508	dehydrogenase complex catalyzes the overall conversion of
C8I07_RS17035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C8I07_RS17045	COG0735	belongs to the Fur family
C8I07_RS17050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C8I07_RS17065	COG0598	Magnesium transport protein CorA
C8I07_RS17070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C8I07_RS17095	COG1301	dicarboxylic acid transport
C8I07_RS17100	COG1470	cell adhesion involved in biofilm formation
C8I07_RS17100	COG1388	LysM domain
C8I07_RS17130	COG1607	acyl-coa hydrolase
C8I07_RS17150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C8I07_RS17150	COG0574	Belongs to the PEP-utilizing enzyme family
C8I07_RS17155	COG0277	FAD linked oxidase domain protein
C8I07_RS17155	COG0247	lactate metabolic process
C8I07_RS17190	COG2850	peptidyl-arginine hydroxylation
C8I07_RS17195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C8I07_RS17215	COG1187	pseudouridine synthase activity
C8I07_RS17225	COG1278	Cold shock
C8I07_RS17235	COG0542	response to heat
C8I07_RS17240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C8I07_RS17245	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C8I07_RS17255	COG3134	Outer membrane lipoprotein
C8I07_RS17290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C8I07_RS17295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C8I07_RS17300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C8I07_RS17305	COG0470	DNA polymerase III
C8I07_RS17315	COG0084	hydrolase, TatD family'
C8I07_RS17325	COG0700	Nucleoside recognition
C8I07_RS17330	COG3008	intermembrane lipid transfer
C8I07_RS17335	COG2995	paraquat-inducible protein a
C8I07_RS17340	COG2995	paraquat-inducible protein a
C8I07_RS17345	COG3141	response to X-ray
C8I07_RS17350	COG1956	GAF domain-containing protein
C8I07_RS17360	COG0793	Belongs to the peptidase S41A family
C8I07_RS17365	COG0308	aminopeptidase N
C8I07_RS17385	COG4447	cellulose binding
C8I07_RS17420	COG3784	Protein of unknown function (DUF1318)
C8I07_RS17435	COG0814	amino acid
C8I07_RS17440	COG0140	phosphoribosyl-ATP diphosphatase activity
C8I07_RS17440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C8I07_RS17455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C8I07_RS17460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C8I07_RS17460	COG0131	Imidazoleglycerol-phosphate dehydratase
C8I07_RS17465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C8I07_RS17470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C8I07_RS17500	COG1199	ATP-dependent helicase activity
C8I07_RS17505	COG4771	TonB-dependent receptor
C8I07_RS17520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8I07_RS17525	COG0583	DNA-binding transcription factor activity
C8I07_RS17540	COG1760	l-serine dehydratase
C8I07_RS17545	COG1472	Belongs to the glycosyl hydrolase 3 family
C8I07_RS17560	COG2113	Glycine betaine
C8I07_RS17565	COG4176	ABC-type proline glycine betaine transport system permease component
C8I07_RS17585	COG0028	Belongs to the TPP enzyme family
C8I07_RS17590	COG0069	glutamate synthase activity
C8I07_RS17605	COG0346	lactoylglutathione lyase activity
C8I07_RS17615	COG0366	Alpha amylase catalytic
C8I07_RS17625	COG0366	Alpha amylase catalytic
C8I07_RS17635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C8I07_RS17635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C8I07_RS17640	COG5001	Diguanylate cyclase
C8I07_RS17640	COG3300	MHYT domain
C8I07_RS17660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C8I07_RS17665	COG1074	ATP-dependent DNA helicase activity
C8I07_RS17670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C8I07_RS17685	COG0714	Associated with various cellular activities
C8I07_RS17700	COG1322	Protein conserved in bacteria
C8I07_RS17705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C8I07_RS17715	COG0346	lactoylglutathione lyase activity
C8I07_RS17725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C8I07_RS17750	COG2878	Part of a membrane complex involved in electron transport
C8I07_RS17790	COG0556	nucleotide-excision repair
C8I07_RS17805	COG0602	queuosine metabolic process
C8I07_RS17855	COG2840	Smr protein MutS2
C8I07_RS17870	COG1960	acyl-CoA dehydrogenase activity
C8I07_RS17875	COG0469	pyruvate kinase activity
C8I07_RS17880	COG1737	Transcriptional regulator
C8I07_RS17885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C8I07_RS17890	COG0363	glucosamine-6-phosphate deaminase activity
C8I07_RS17895	COG0129	dihydroxy-acid dehydratase activity
C8I07_RS17900	COG0800	Aldolase
C8I07_RS17910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C8I07_RS17915	COG0436	Aminotransferase
C8I07_RS17920	COG1757	Na H antiporter
C8I07_RS17955	COG0596	Alpha beta hydrolase
C8I07_RS17960	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C8I07_RS17965	COG0033	Phosphoglucomutase
C8I07_RS17970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C8I07_RS17980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C8I07_RS17985	COG0022	dehydrogenase e1 component
C8I07_RS17990	COG0508	dehydrogenase complex catalyzes the overall conversion of
C8I07_RS18000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C8I07_RS18030	COG1448	Aminotransferase
C8I07_RS18035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C8I07_RS18040	COG2992	FlgJ-related protein
C8I07_RS18055	COG0589	response to stress
C8I07_RS18060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8I07_RS18075	COG2217	Heavy metal translocating P-type atpase
C8I07_RS18085	COG2010	Cytochrome c
C8I07_RS18100	COG3278	Belongs to the heme-copper respiratory oxidase family
C8I07_RS18110	COG0784	Response regulator, receiver
C8I07_RS18110	COG3437	response regulator, receiver
C8I07_RS18165	COG5002	protein histidine kinase activity
C8I07_RS18170	COG0745	RESPONSE REGULATOR receiver
C8I07_RS18175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8I07_RS18180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8I07_RS18200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C8I07_RS18205	COG3344	reverse transcriptase
C8I07_RS18280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C8I07_RS18280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C8I07_RS18310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C8I07_RS18315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C8I07_RS18325	COG1401	restriction endodeoxyribonuclease activity
C8I07_RS18400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C8I07_RS18440	COG0402	S-adenosylhomocysteine deaminase activity
C8I07_RS18450	COG2814	Major facilitator Superfamily
C8I07_RS18455	COG0583	DNA-binding transcription factor activity
C8I07_RS18460	COG0670	Belongs to the BI1 family
C8I07_RS18465	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C8I07_RS18470	COG2923	Belongs to the DsrF TusC family
C8I07_RS18480	COG2920	part of a sulfur-relay system
C8I07_RS18500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C8I07_RS18510	COG1674	ftsk spoiiie
C8I07_RS18510	COG0531	amino acid
C8I07_RS18520	COG0686	Belongs to the AlaDH PNT family
C8I07_RS18525	COG0492	ferredoxin-NADP+ reductase activity
C8I07_RS18530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C8I07_RS18560	COG0307	riboflavin synthase, alpha
C8I07_RS18565	COG0534	Mate efflux family protein
C8I07_RS18600	COG4773	Receptor
C8I07_RS18640	COG4628	conserved protein (DUF2132)
C8I07_RS18645	COG0488	(ABC) transporter
C8I07_RS18665	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C8I07_RS18675	COG0840	transmembrane signaling receptor activity
C8I07_RS18680	COG0835	chemotaxis
C8I07_RS18705	COG0840	transmembrane signaling receptor activity
C8I07_RS18710	COG1042	CoA-binding domain protein
C8I07_RS18710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C8I07_RS18710	COG0045	succinate-CoA ligase (ADP-forming) activity
C8I07_RS18715	COG3706	GGDEF domain
C8I07_RS18720	COG2194	sulfuric ester hydrolase activity
C8I07_RS18725	COG1505	serine-type exopeptidase activity
C8I07_RS18740	COG4574	serine-type endopeptidase inhibitor activity
C8I07_RS18750	COG0514	ATP-dependent DNA helicase (RecQ)
C8I07_RS18775	COG3148	PFAM DTW domain containing protein
C8I07_RS18785	COG2814	Major facilitator Superfamily
C8I07_RS18790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C8I07_RS18805	COG2027	D-alanyl-D-alanine carboxypeptidase
C8I07_RS18810	COG1960	acyl-CoA dehydrogenase activity
C8I07_RS18815	COG3122	Protein conserved in bacteria
C8I07_RS18820	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS18825	COG0284	orotidine-5'-phosphate decarboxylase activity
C8I07_RS18830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C8I07_RS18835	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C8I07_RS18845	COG0539	negative regulation of cytoplasmic translation
C8I07_RS18860	COG1448	Aminotransferase
C8I07_RS18865	COG1328	CTP reductase activity
C8I07_RS18870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C8I07_RS18900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C8I07_RS18910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8I07_RS18915	COG1902	pentaerythritol trinitrate reductase activity
C8I07_RS18915	COG0446	pyridine nucleotide-disulphide oxidoreductase
C8I07_RS18920	COG0616	signal peptide processing
C8I07_RS18925	COG0252	asparaginase activity
C8I07_RS18930	COG3139	Protein of unknown function (DUF1315)
C8I07_RS18940	COG2866	Carboxypeptidase
C8I07_RS18950	COG0745	RESPONSE REGULATOR receiver
C8I07_RS18975	COG0217	transcriptional regulatory protein
C8I07_RS19000	COG0189	ligase activity
C8I07_RS19000	COG4067	protein conserved in archaea
C8I07_RS19035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C8I07_RS19060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C8I07_RS19070	COG1272	protein, Hemolysin III
C8I07_RS19080	COG0494	nUDIX hydrolase
C8I07_RS19090	COG1082	Xylose isomerase domain protein TIM barrel
C8I07_RS19100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C8I07_RS19145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C8I07_RS19155	COG2850	peptidyl-arginine hydroxylation
C8I07_RS19160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C8I07_RS19160	COG1199	ATP-dependent helicase activity
C8I07_RS19165	COG1609	Transcriptional regulator
C8I07_RS19175	COG0840	transmembrane signaling receptor activity
C8I07_RS19185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C8I07_RS19190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C8I07_RS19200	COG2211	Major facilitator Superfamily
C8I07_RS19210	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C8I07_RS19215	COG1393	Belongs to the ArsC family
C8I07_RS19225	COG1876	peptidase activity
C8I07_RS19245	COG0288	reversible hydration of carbon dioxide
C8I07_RS19250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C8I07_RS19255	COG1454	alcohol dehydrogenase
C8I07_RS19300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8I07_RS19310	COG2814	Major facilitator Superfamily
C8I07_RS19315	COG0028	Belongs to the TPP enzyme family
C8I07_RS19365	COG0316	Belongs to the HesB IscA family
C8I07_RS19370	COG0822	iron-sulfur transferase activity
C8I07_RS19380	COG1959	2 iron, 2 sulfur cluster binding
C8I07_RS19390	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C8I07_RS19400	COG4591	ABC-type transport system involved in lipoprotein release permease component
C8I07_RS19405	COG1136	(ABC) transporter
C8I07_RS19410	COG4591	ABC-type transport system involved in lipoprotein release permease component
C8I07_RS19420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C8I07_RS19430	COG1254	Belongs to the acylphosphatase family
C8I07_RS19470	COG0242	peptide deformylase activity
C8I07_RS19485	COG0121	glutamine amidotransferase
C8I07_RS19490	COG1960	acyl-CoA dehydrogenase activity
C8I07_RS19520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C8I07_RS19530	COG0583	DNA-binding transcription factor activity
C8I07_RS19535	COG2226	methyltransferase
C8I07_RS19545	COG1388	LysM domain
C8I07_RS19545	COG0741	lytic transglycosylase activity
C8I07_RS19560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C8I07_RS19580	COG0513	Belongs to the DEAD box helicase family
C8I07_RS19585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C8I07_RS19595	COG4771	TonB-dependent receptor
C8I07_RS19600	COG1288	antiporter activity
C8I07_RS19655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C8I07_RS19655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C8I07_RS19660	COG3550	peptidyl-serine autophosphorylation
C8I07_RS19680	COG0732	type I restriction modification DNA specificity domain
C8I07_RS19715	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C8I07_RS19725	COG0582	viral genome integration into host DNA
C8I07_RS19740	COG2095	MarC family integral membrane protein
C8I07_RS19745	COG1012	belongs to the aldehyde dehydrogenase family
C8I07_RS19745	COG1454	alcohol dehydrogenase
C8I07_RS19760	COG1506	peptidase
C8I07_RS19760	COG0823	Involved in the tonB-independent uptake of proteins
C8I07_RS19795	COG3005	denitrification pathway
C8I07_RS19800	COG3043	anaerobic respiration
C8I07_RS19805	COG0243	molybdopterin cofactor binding
C8I07_RS19810	COG3062	negative regulation of establishment of protein localization
C8I07_RS19820	COG1643	Atp-dependent helicase
C8I07_RS19840	COG0729	surface antigen
C8I07_RS19865	COG3108	Peptidase M15
C8I07_RS19870	COG2989	Protein conserved in bacteria
C8I07_RS19890	COG0642	Histidine kinase
C8I07_RS19895	COG0745	RESPONSE REGULATOR receiver
C8I07_RS19900	COG1477	protein flavinylation
C8I07_RS19920	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C8I07_RS19925	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C8I07_RS19930	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C8I07_RS19935	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C8I07_RS19945	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C8I07_RS19950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C8I07_RS19955	COG0298	carbon dioxide binding
C8I07_RS19960	COG0409	Hydrogenase expression formation protein
C8I07_RS19965	COG0309	Hydrogenase expression formation protein (HypE)
C8I07_RS19975	COG1560	Kdo2-lipid A biosynthetic process
C8I07_RS19985	COG0072	phenylalanine-tRNA ligase activity
C8I07_RS19985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C8I07_RS19995	COG0840	transmembrane signaling receptor activity
C8I07_RS20020	COG2894	cell division
C8I07_RS20030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C8I07_RS20035	COG0318	PFAM AMP-dependent synthetase and ligase
C8I07_RS20040	COG2267	carboxylic ester hydrolase activity
C8I07_RS20060	COG1214	PFAM Peptidase M22, glycoprotease
C8I07_RS20065	COG0113	porphobilinogen synthase activity
C8I07_RS20070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C8I07_RS20080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C8I07_RS20085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C8I07_RS20100	COG1793	dna ligase
C8I07_RS20105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C8I07_RS20110	COG0583	DNA-binding transcription factor activity
C8I07_RS20120	COG0189	ligase activity
C8I07_RS20135	COG3706	GGDEF domain
C8I07_RS20155	COG0745	RESPONSE REGULATOR receiver
C8I07_RS20160	COG2205	protein histidine kinase activity
C8I07_RS20165	COG0626	cystathionine gamma-synthase activity
C8I07_RS20175	COG0443	Heat shock 70 kDa protein
C8I07_RS20180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C8I07_RS20185	COG0248	Ppx GppA phosphatase
C8I07_RS20190	COG0484	heat shock protein binding
C8I07_RS20250	COG0437	4 iron, 4 sulfur cluster binding
C8I07_RS20255	COG0243	molybdopterin cofactor binding
C8I07_RS20310	COG0456	acetyltransferase
C8I07_RS20380	COG0537	adenosine 5'-monophosphoramidase activity
C8I07_RS20395	COG2197	response regulator
C8I07_RS20405	COG1053	succinate dehydrogenase
C8I07_RS20410	COG0628	permease
C8I07_RS20420	COG4783	chaperone-mediated protein folding
C8I07_RS20425	COG1393	Belongs to the ArsC family
C8I07_RS20455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C8I07_RS20465	COG2766	serine protein kinase
C8I07_RS20470	COG2718	Belongs to the UPF0229 family
C8I07_RS20475	COG2719	SpoVR family
C8I07_RS20560	COG0776	regulation of translation
C8I07_RS20565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C8I07_RS20570	COG2226	methyltransferase
C8I07_RS20575	COG0156	8-amino-7-oxononanoate synthase activity
C8I07_RS20590	COG0840	transmembrane signaling receptor activity
C8I07_RS20595	COG5002	protein histidine kinase activity
C8I07_RS20605	COG1061	Type III restriction enzyme res subunit
C8I07_RS20670	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C8I07_RS20675	COG2885	chlorophyll binding
C8I07_RS20695	COG0811	peptide transport
C8I07_RS20700	COG0824	Thioesterase
C8I07_RS20705	COG1505	serine-type exopeptidase activity
C8I07_RS20710	COG2885	chlorophyll binding
C8I07_RS20720	COG0450	alkyl hydroperoxide reductase
C8I07_RS20725	COG2056	Na+-H+ antiporter family
C8I07_RS20740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C8I07_RS20745	COG0647	UMP catabolic process
C8I07_RS20760	COG0367	asparagine synthase
C8I07_RS20765	COG4667	esterase of the alpha-beta hydrolase superfamily
C8I07_RS20790	COG1960	acyl-CoA dehydrogenase activity
C8I07_RS20800	COG2084	Dehydrogenase
C8I07_RS20815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8I07_RS20820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8I07_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
C8I07_RS20830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C8I07_RS20835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8I07_RS20850	COG1399	metal-binding, possibly nucleic acid-binding protein
C8I07_RS20855	COG0424	maF-like protein
C8I07_RS20860	COG0546	phosphoglycolate phosphatase activity
C8I07_RS20870	COG1530	ribonuclease E activity
C8I07_RS20875	COG0659	secondary active sulfate transmembrane transporter activity
C8I07_RS20880	COG1278	Cold shock
C8I07_RS20885	COG2226	methyltransferase
C8I07_RS20950	COG2925	Exonuclease
C8I07_RS21010	COG1132	(ABC) transporter
C8I07_RS21015	COG0658	competence protein
C8I07_RS21015	COG2333	competence protein COMEC
C8I07_RS21055	COG3275	phosphorelay sensor kinase activity
C8I07_RS21060	COG3279	Response regulator of the LytR AlgR family
C8I07_RS21065	COG1966	Carbon starvation protein
C8I07_RS21070	COG4628	conserved protein (DUF2132)
C8I07_RS21095	COG0602	queuosine metabolic process
C8I07_RS21100	COG1328	CTP reductase activity
C8I07_RS21110	COG1846	Transcriptional regulator
C8I07_RS21115	COG2130	NADP-dependent
C8I07_RS21120	COG1752	Esterase of the alpha-beta hydrolase superfamily
C8I07_RS21125	COG0513	Belongs to the DEAD box helicase family
C8I07_RS21135	COG1451	nucleotide metabolic process
C8I07_RS21145	COG0739	heme binding
C8I07_RS21150	COG0419	ATPase involved in DNA repair
C8I07_RS21155	COG0420	3'-5' exonuclease activity
C8I07_RS21160	COG0730	response to heat
C8I07_RS21175	COG2501	S4 domain
C8I07_RS21185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C8I07_RS21210	COG0848	biopolymer transport protein
C8I07_RS21215	COG0811	peptide transport
C8I07_RS21220	COG0811	peptide transport
C8I07_RS21245	COG5433	transposase activity
C8I07_RS21255	COG3293	Transposase
C8I07_RS21290	COG0417	DNA replication proofreading
C8I07_RS21295	COG1199	ATP-dependent helicase activity
C8I07_RS21315	COG0123	including yeast histone deacetylase and acetoin utilization protein
C8I07_RS21330	COG1555	photosystem II stabilization
C8I07_RS21330	COG1596	polysaccharide export
C8I07_RS21340	COG3768	UPF0283 membrane protein
C8I07_RS21345	COG3106	COG3106 Predicted ATPase
C8I07_RS21360	COG1842	Phage shock protein A
C8I07_RS21365	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C8I07_RS21370	COG0747	negative chemotaxis
C8I07_RS21375	COG4168	peptide transport system, permease
C8I07_RS21380	COG4171	peptide transport system, permease
C8I07_RS21390	COG4172	Belongs to the ABC transporter superfamily
C8I07_RS21400	COG3585	molybdate ion transport
C8I07_RS21405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation